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Sample records for volume editor werner

  1. Editors' overview for the Alan Turner Memorial volume

    Science.gov (United States)

    O'Regan, Hannah J.; Elton, Sarah; Schreve, Danielle

    2014-07-01

    The papers presented here, in this special volume dedicated to the memory of Alan Turner (1947-2012), provide a glimpse of the multi-faceted ways in which the mammalian fossil record can be investigated. The authors of contributions in this Special Issue are by no means an exhaustive list of his international collaborators and colleagues, and indeed, many are not represented here, but the contents cover many of the topics and issues that were of central archaeological and wider Quaternary mammalian interest to Alan. Although the papers are not intended to provide a comprehensive overview of all techniques that can be applied, the set nevertheless reveals a snapshot of the state-of-the-art and of some of the methods that have the potential to bring much more of the past to life. Alan always sought to move beyond the 'stamp-collecting' approach of simply listing which taxa were present at a site, attempting to elucidate what the presence of those animals might mean in terms of palaeoecology. In particular, the span of Alan's career has seen major advances in our understanding of Quaternary mammalian biostratigraphy and palaeobiogeography, the widespread application of novel techniques such as ancient DNA, the development of high-precision geochronology and the discovery of new hominin species. The papers presented here reflect those developments and highlight interdisciplinary approaches, from examination of sediments to careful measurements of the fossils themselves, from modelling the presence of taxa at particular points in the Quaternary to examination of the similarities and differences in fauna within and between sites.

  2. From Editor

    OpenAIRE

    Ugur Demiray

    2013-01-01

    Dear TOJDE Readers, Welcome to the Volume 14 Number: 2 of TOJDE! In this issue, 3 Notes for Editor, 2 Book Reviews and 21 articles of 40 authors from 14 different countries around the world have been published. These published articles are arrived to the TOJDE from Argentina, Australia, Bosnia Hersek, Egypt, India, Malaysia, Romania, Saudi Arabia, Tanzania, Thailand, Turkey, United Arab Emirate and USA. The 1st Notes for Editor is arrived from USA and written by Gail D. CARUTH,...

  3. From Editor

    OpenAIRE

    Ugur Demiray

    2013-01-01

    Dear TOJDE Readers, Welcome to the Volume 14 Number: 2 of TOJDE! In this issue, 3 Notes for Editor, 2 Book Reviews and 21 articles of 40 authors from 14 different countries around the world have been published. These published articles are arrived to the TOJDE from Argentina, Australia, Bosnia Hersek, Egypt, India, Malaysia, Romania, Saudi Arabia, Tanzania, Thailand, Turkey, United Arab Emirate and USA. The 1st Notes for Editor is arrived from USA and written by Gail D. CARUTH,...

  4. Genetics Home Reference: Werner syndrome

    Science.gov (United States)

    ... for This Condition Adult premature aging syndrome Adult Progeria Werner's Syndrome Werners Syndrome WS Related Information How ... BK, Monnat RJ Jr. Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases. Nat ...

  5. From Editor

    OpenAIRE

    Demiray, Ugur

    2012-01-01

    Turkish Online Journal of Distance Education-TOJDE July 2012 ISSN 1302-6488 Volume: 13 Number: 3 from EditorDear TOJDE Readers,Welcome to the Volume 13 Number: 3 of TOJDE! In this issue, 2 Notes for Editor and 26 articles of 51 authors from 14 different countries around the world have been published. These published articles are from, Algeria, Australia, Bengaldesh, Greece, India, Iran, Malaysia, Mariutius, Nigeria, Oman, Spain, Turkey, USA and Zimbabwe.First all, you should know that if a su...

  6. From Editor

    OpenAIRE

    Ugur DEmiray

    2011-01-01

    Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 12, Number: 1. In this issue it is published 4 notes for Editor, 13 articles, 2 book reviews. And this time, 34 authors from 11 different countries are placed. These published articles are from Cayman Islands, Germany, Greece, India, Iran, Malaysia, Pakistan, Turkey, USA and Zimbabwe.The first Notes for editor arrived from USA, written by Kevin YEE and Jace HARGIS. They focused on “SNAPP:Graphing Student Interactio...

  7. From Editor

    OpenAIRE

    Ugur Demiray

    2010-01-01

    Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now again after 3 months as Volume 11, Number: 2. This is the second issue of the year 2010. In this issue it is published four Notes for Editor, fourteen articles and four book reviews. And this time, 37 authors from 8 different countries are placed. These published articles are from Greece, Indonesia, Iran, Malaysia, Pakistan, Saudi Arabia, USA and Turkey.Again Kevin YEE & Jace HARGIS have sent a good and short note to editor ...

  8. From editor

    OpenAIRE

    Ugur Demiray

    2009-01-01

    Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now. This is the third issue ue of the year 2009 and 10th anniversary of TOJDE as Volume 10, Number: 3. In this issue it is published three notes for Editor, 15 articles, 3 book reviews. And this time, 30 authors from 10 different countries are placed in TOJDE. These published articles are from Australia, Bangladesh, Greece, India, Indonesia, Norway, Nigeria, Pakistan, Turkey and USAThe first Notes for editor arrived from Pakist...

  9. From editor

    OpenAIRE

    Ugur Demiray

    2009-01-01

    Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now. This is the third issue ue of the year 2009 and 10th anniversary of TOJDE as Volume 10, Number: 3. In this issue it is published three notes for Editor, 15 articles, 3 book reviews. And this time, 30 authors from 10 different countries are placed in TOJDE. These published articles are from Australia, Bangladesh, Greece, India, Indonesia, Norway, Nigeria, Pakistan, Turkey and USAThe first Notes for editor arrived from Pakist...

  10. From Editor

    OpenAIRE

    Ugur Demiray

    2012-01-01

    Dear TOJDE Readers,Welcome to the Volume 13 Number: 2 of TOJDE! In this issue, 7 notes for Editor and 22 articles one book review of 57 authors from 12 different countries have been published. These published articles are from, Barbados, Ethiopia, India, Indonesia, Iran, Nigeria, Pakistan, Russia, Saudi Arabia, Turkey, USA and Zimbabwe.In general, around 13 articles and 4 notes for editors have been published in TOJDE so far. I would like to explain, why this time 22 articles and 8 submission...

  11. In Memoriam Werner Callebaut.

    Science.gov (United States)

    Boniolo, Giovanni

    2015-12-01

    The article contains some recollections on Werner Callebaut highlighting his personal character and his role in the community of historians, philosophers and sociologists of the life sciences. Werner Callebaut (1952-2014) was a real European philosopher. He was the Scientific Director of the Konrad Lorenz Institute for Evolution and Cognition Research (KLI, Klosterneuburg, Austria) and the President of the International Society for the History, Philosophy, and Social Studies of Biology.

  12. Werner Albrecht (1924 - 2014)

    CERN Multimedia

    2014-01-01

    Werner Albrecht, one of the very first mechanical designers recruited by CERN, passed away on 28 March. Born and educated in Zurich, where he spent the first years of his professional life, he joined CERN in June 1955.   Thanks to his experience and personality, he soon became the deputy to Frank Blythe, the head of the Synchrocyclotron (SC) technical office. The office, which included a large mechanical workshop, had been created in the light of the development and construction of the SC - the first of CERN’s accelerators. For around 25 years Werner kept this position at Frank’s side while the services under their responsibility evolved to become the natural facility to provide design and development for a large range of apparatus required by experimental physicists. After Frank’s retirement in 1980, Werner became head of the office, maintaining its typical character as an efficient, informal and friendly service. Omega, UA1, Aleph, Opal and Delphi are example...

  13. Correlations in Werner States

    Institute of Scientific and Technical Information of China (English)

    DONG Li; LUO Shun-Long; XIU Xiao-Ming; LI Nan; GAO Ya-Jun; CHI Feng

    2008-01-01

    Werner states are paradigmatic examples of quantum states and play an innovative role in quantum information theory. In investigating the correlating capability of Werner states, we find the curious phenomenon that quantum correlations, as quantified by the entanglement of formation, may exceed the total correlations, as measured by the quantum mutual information. Consequently, though the entanglement of formation is so widely used in quantifying entanglement, it cannot be interpreted as a consistent measure of quantum correlations per se if we accept the folklore that total correlations are measured (or rather upper bounded) by the quantum mutual information.

  14. From Editor

    OpenAIRE

    Ugur Demiray

    2008-01-01

    Greetings Dear readers of TOJDE, TOJDE is appeared on your screen now as Volume 9, Number: 4. This is the fourth and the last issue of the year 2008. In this issue it is published two notes for Editor, 13 articles, 2 reviews. And this time, 23 authors from seven different countries are placed. These published articles are from Bangladesh, India, Malaysia, Nigeria, Saudi Arabia, USA and Turkey. “Ubiquitous, Free, And Efficient Online Collaboration Tools For Teaching And Learning” has sent to e...

  15. From Editor

    OpenAIRE

    Ugur Demiray

    2009-01-01

    TOJDE is appeared on your screen now as Volume 10, Number: 1. This is the first issue of the year 2009 and 10th anniversary of TOJDE. In this issue it is published four article are in “Notes for Editor Sectio”, 13 articles, 2 reviews. And this time, 26 authors from twelwe different countries are placed. These published articles are from Australia, Botswana, Canada, Italy India, Jordan, Malaysia, Nigeria, Srilanka, USA and Turkey. “Service Learning In Distance Education: Foreign Language Lear...

  16. Fnom Editor

    OpenAIRE

    Ugur Demiray

    2006-01-01

    Greetings Dear readers of TOJDE, I am pleased to inform you that in the 7th year of TOJDE is appeared as Volume 7, Number: 1 on your screen now as. Very much thanks to all of you once more that we met 21st time, since January 2000. In this issue we published 15 articles, four book reviews, one notes for editor, news and announcements for our readers. And also, we give a place for the Call for Papers to the 4th Special Issue of The Turkish Online Journal of Distance Education (TOJDE) ...

  17. From the Editor

    OpenAIRE

    Ugur Demiray

    2011-01-01

    Turkish Online Journal of Distance Education-TOJDE April 2011 ISSN 1302-6488 Volume: 12 Number: 2 from EditorGreetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 12, Number: 2. In this issue it is published 4 notes for Editor, 14 articles, 1 book review. And this time, 43 authors from 10 different countries are placed. These published articles are from Austrlia, Bangldesh, India, lndonasia, Iran, Malaysia. Pakistan, Serbia, Turkey and USA.The first Notes for editor a...

  18. From the Editor

    OpenAIRE

    Ugur Demiray

    2011-01-01

    Turkish Online Journal of Distance Education-TOJDE April 2011 ISSN 1302-6488 Volume: 12 Number: 2 from EditorGreetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 12, Number: 2. In this issue it is published 4 notes for Editor, 14 articles, 1 book review. And this time, 43 authors from 10 different countries are placed. These published articles are from Austrlia, Bangldesh, India, lndonasia, Iran, Malaysia. Pakistan, Serbia, Turkey and USA.The first Notes for editor a...

  19. Editor's Note

    Directory of Open Access Journals (Sweden)

    Daniel Shanahan

    2016-07-01

    Full Text Available CORPUS studies have increasingly been of interest to music theorists, musicologists, and music psychology researchers, as is evident in the sheer number of excellent submissions to this special issue. The breadth and depth of these articles, as well as the insightful commentaries, make it seem only fitting to publish over two issues. The current issue contains five articles, eight commentaries, and one research report, and covers folk music, post-tonal music, jazz, Western art music, and the popular music found on Youtube. Eerola presents a model of melodic entropy that provides a nice framework for future information-theoretic work, while Roger Dean and Marcus Pearce present a new approach to modelling pitch-structure in post-tonal music. Frieler, Pfleiderer, Abeßer, and Zaddach give an analysis of jazz solos that demonstrates the role of a narrative arcs in improvisation. White and Quinn present a new corpus that makes use of vast compilations of web-based MIDI data, and demonstrates how such a corpus might be facilitate future musicological and music-theoretic research. Plazak focuses on Youtube as a corpus, and argues that the mutability of such a corpus facilitates our understanding of musical communication, as well as the important role of the listener in defining and re-defining such a dataset. It's encouraging to me both as an editor and practitioner of corpus methods that so many of those heavily involved with the field contributed to these two issues as either an author or a commentator. This issue also brings a number of changes on other fronts. Firstly, Nicola Dibben and Renee Timmers, who served as the journal's editors since Volume 7, have completed their editorial terms. They oversaw the transformation of the journal into a new Open Journal Systems platform, and were able to consistently produce issues that set a very high standard. Under their leadership, the journal both increased its accessibility (we now average more than 1

  20. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2013-04-01

    Full Text Available Dear TOJDE Readers, Welcome to the Volume 14 Number: 2 of TOJDE! In this issue, 3 Notes for Editor, 2 Book Reviews and 21 articles of 40 authors from 14 different countries around the world have been published. These published articles are arrived to the TOJDE from Argentina, Australia, Bosnia Hersek, Egypt, India, Malaysia, Romania, Saudi Arabia, Tanzania, Thailand, Turkey, United Arab Emirate and USA. The 1st Notes for Editor is arrived from USA and written by Gail D. CARUTH, Department of Educational Leadership Texas A&M University and Donald L. CARUTH Texas USA, from Independent Management Consultant, on “Understanding Resistance To Change: A Challenge For Universities”. This paper explores organizational change and the challenge it poses for universities. Because universities are slow to change due to maintaining a balance of tradition and change successful implementation of change will continue to be a challenge both now and in the future. The challenge of change is real but the task is not impossible. Historically, universities have met the challenges that faced them, they must be prepared to confront this challenge too. The 2nd Notes for Editor is arrived from UAE, in the context of “iPAD LEARNING ECOSYSTEM: Developing Challenge-Based Learning using Design Thinking” which iritten by Catalina MARIN, Jace HARGIS and Cathy CAVANAUGH,HCT ADWC, Abu Dhabi, UAE. This article describes the course design, which was grounded in design thinking, and provides an overview of the pilot implementation of the course. The course achieved its goals to a great extent in that learners felt that they were beginning to help build a better college community by sharing stories of their learning experience and their insights about the essential question they chose with other students and with other teachers. Third Notes for Editor titled as “ Use of Distance Education By Chritian religion to Train Edify and Educate Adherents” and written by Dr. P

  1. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur DEMIRAY

    2012-07-01

    Full Text Available Turkish Online Journal of Distance Education-TOJDE July 2012 ISSN 1302-6488 Volume: 13 Number: 3 from EditorDear TOJDE Readers,Welcome to the Volume 13 Number: 3 of TOJDE! In this issue, 2 Notes for Editor and 26 articles of 51 authors from 14 different countries around the world have been published. These published articles are from, Algeria, Australia, Bengaldesh, Greece, India, Iran, Malaysia, Mariutius, Nigeria, Oman, Spain, Turkey, USA and Zimbabwe.First all, you should know that if a submission picks up from 3 TOJDE editors between 4.5 and 9 over all 9 credits, it means that this submission can be published in TOJDE in the coming issues. However, since the publishing priority of the accepted papers belongs to the highest scored ones, submissions which receive a score between 4.5 and 5 or 6 should wait and be archived for publishing later on. TOJDE administration respected this publishing rule up to now. Therefore, some accepted submissions which obtained over 4.5 have not been published yet up to now. These submissions were waiting for publishing in TOJDE in the future. In this issue, we decided to give them a chance to be published. For this reason, the current issue includes more papers than the previous issues. The 1st Notes for editor arrived from USA and written by Steve McCREA on Transforming Teachers, Transforming Schools: Turning "Sages" Into "Guides on The Side". He mentioned that teachers, educational managers and learners must realize that new opportunities are offered by modern communication. When a teacher becomes a "guide on the side," there is a change in the school's culture that can be measured. This presentation is extracted from a newly published book, Let's Lecture Less, edited by Steve McCrea (Visualandactive.com and Mario Joel Llorente Leyva. The 2nd notes for editor is titled as “Challenges Encountered By A Distance Learning Organisation” which is written by Dr. Sangeeta MALIK, from Education, Humanities and

  2. Early Onset Werner Syndrome

    Directory of Open Access Journals (Sweden)

    Berna İmge Aydoğan

    2015-09-01

    Full Text Available Werner syndrome (WS is a rare autosomal recessive adult-onset progeroid disorder characterized by the early onset of aged-appearance and age-related metabolic disorders. Symptoms of premature aging usually first develop in the second-third decades of life. We report a 27-year-old female who was admitted to our clinic at the age of eighteen with hyperglycemia. She was diagnosed with diabetes and type 4 dyslipidemia at the age of seven. In her family history, her parents were first cousins and she had three healthy brothers. On her first physical examination; she had bird-like face appearance, global hair loss, beaked nose, short stature and she was overweight. She had global hair loss with gray and thin hair. Hoarseness of voice and hyperkeratosis of skin were observed. She had bilateral cataracts and moderate sensorineural hearing loss. On psychiatric examination, borderline mental retardation was detected. She had severe insulin resistance and hypertriglyceridemia despite levothyroxine, gemfibrozil, omega-3 and intensive insulin treatment. Routine lipid apheresis was performed to lower the triglyceride levels reaching 5256 mg/dL. She also had focal segmental glomerulosclerosis, hepatosteatosis, osteoporosis and epilepsy. Disease was accompanied by several congenital deformities, such as Rathke’s cleft cyst, angiomyolipoma and femoral neck hypoplasia. WS is a rare genetic disorder characterized by multiple endocrine manifestations as well as soft tissue changes. We present a case of early disturbances that were diagnosed before typical clinical signs and symptoms. We propose that WS should be kept in mind when type 2 diabetes and hyperlipidemia are diagnosed early in childhood. Turk Jem 2015; 19: 99-104

  3. Werner's Relevance for Contemporary Developmental Psychology.

    Science.gov (United States)

    Glick, Joseph A.

    1992-01-01

    Considers the contributions of Heinz Werner to developmental psychology and identifies the tensions between Werner's theory and the practices of contemporary developmental psychology. Core issues of Werner's psychology concern: (1) development as heuristic, rather than phenomenon; (2) developmental process analysis; and (3) conceptions of the…

  4. Guest Editors' Preface

    Science.gov (United States)

    Gille, Peter; Miller, Wolfram; Sangwal, Keshra; Talik, Ewa

    2014-09-01

    The 17th International Conference on Crystal Growth and Epitaxy (ICCGE-17) was held in Warsaw during 11 and 16 August 2013. The contributions during the ICCGE-17 were of three types: Invited lectures, oral presentations and poster presentions. The conference participants were also invited to submit manuscripts based on their contributions for publication in the ICCGE-17 Proceedings volume of Journal of Crystal Growth. The present volume contains manuscripts accepted by the guest editors for this conference volume.

  5. Editors' Note: Volume Overview

    Directory of Open Access Journals (Sweden)

    Jana Cason

    2013-12-01

    Full Text Available This issue of the International Journal of Telerehabilitation (IJT contains original research evaluating the efficacy of telerehabilitation; a randomized study measuring costs and outcomes of tele-intervention when serving families of children who are deaf/hard-of-hearing; and a telephone-based physiotherapy intervention for patients with osteoarthritis of the knee. A feasibility study on the use of e-supervision to support speech-language pathologist graduate students during student teaching practica outlines benefits, limitations, and implications for future practice. In addition to innovative research, this issue includes announcements from the American Telemedicine Association and the Mid-Atlantic Telehealth Resource Center.  

  6. Werner Herzog Tallinnas / Aare Ermel

    Index Scriptorium Estoniae

    Ermel, Aare, 1957-2013

    2002-01-01

    Detsembris toimuvat Pimedate Ööde Filmifestivali laiendatakse ka suvele, et sobivates paikades näidata väärtfilme. Alates 6. juunist näidatakse Katariina kirikus kuuel õhtul algusega kell 22 Werner Herzogi (1942) filme. Režissöörist ja näidatavatest filmidest

  7. Werner Herzog Tallinnas / Aare Ermel

    Index Scriptorium Estoniae

    Ermel, Aare, 1957-2013

    2002-01-01

    Detsembris toimuvat Pimedate Ööde Filmifestivali laiendatakse ka suvele, et sobivates paikades näidata väärtfilme. Alates 6. juunist näidatakse Katariina kirikus kuuel õhtul algusega kell 22 Werner Herzogi (1942) filme. Režissöörist ja näidatavatest filmidest

  8. Letter from the Editors

    Directory of Open Access Journals (Sweden)

    The Editors

    2013-07-01

    Full Text Available With grateful hearts we offer this, the first issue of our third volume. The result of months of back-breaking thinking, emailing, looking, clicking, watching, writing and reading, our new issue is here. The editors could not have done this without your support. We welcome your materials for our future issues as well as your continued contributions.

  9. Letter from the Editors

    Directory of Open Access Journals (Sweden)

    Paul Boshears

    2012-11-01

    Full Text Available With grateful hearts we offer this, the third issue of our second volume. The result of months of back-breaking thinking, emailing, looking, clicking, watching, writing and reading, our fall issue is here. The editors could not have done this without your support. We welcome your materials for our future issues as well as your continued contributions.

  10. Letter from the Editors

    Directory of Open Access Journals (Sweden)

    Paul Boshears

    2012-08-01

    Full Text Available With grateful hearts we offer this, the second issue of our second volume. The result of months of back-breaking thinking, emailing, looking, clicking, watching, writing and reading, our summer issue is here. The editors could not have done this without your support. We welcome your materials for our future issues as well as your continued contributions.

  11. From the Editor

    OpenAIRE

    Ugur Demiray

    2011-01-01

    Dear readers of TOJDE,TOJDE appears on your screen now as Volume 12, Number: 4. In this issue it publishes 5 notes for Editor, 10 articles, 2 book reviews. And this time, 33 authors from 10 different countries are placed. These published articles are from Bangladesh, Ethiopia, India, Malaysia, Nigeria, Pakistan, Saudi Arabia, Turkey, UAE and USA. The first Notes for editor arrived from USA, written by Kevin YEE and Jace HARGIS. They focused on Google+ is like Twitter in that anyone can follo...

  12. From the Editor

    OpenAIRE

    Ugur Demiray

    2012-01-01

    Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 13 Number: 1 In this issue it is published 5 notes for Editor, 16articles, 2 books reviews a nd this time, 53 authors from 12 different countries are placed. These published articles are from Azerbaijan, Bangladesh, Greece, Iran, Malaysia, Morocco, Nigeria, Pakistan, Turkey, UAE and USA.The first Notes for editor arrived from USA, written by Kevin YEE and Jace HARGIS. They focused on Simply including a narrative co...

  13. From the Editor

    OpenAIRE

    Ugur Demiray

    2012-01-01

    Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 13 Number: 1 In this issue it is published 5 notes for Editor, 16articles, 2 books reviews a nd this time, 53 authors from 12 different countries are placed. These published articles are from Azerbaijan, Bangladesh, Greece, Iran, Malaysia, Morocco, Nigeria, Pakistan, Turkey, UAE and USA.The first Notes for editor arrived from USA, written by Kevin YEE and Jace HARGIS. They focused on Simply including a narrative co...

  14. From the Editor

    OpenAIRE

    Ugur Demiray

    2009-01-01

    Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 10, Number: 2. This is the second issue of the year 2009 and 10th anniversary of TOJDE. In this issue it is published four notes for Editor, 13 articles, 2 reviews. And this time, 28 authors from 8 different countries are placed. These published articles are from Canada, Gana, India, Iran, Malaysia, Pakistan, United Kingdom and Turkey. “Reflective Approach In Teaching Pre-Degree Chemistry” has sent to editor of TOJ...

  15. From the Editor

    OpenAIRE

    Ugur Demiray

    2009-01-01

    Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 10, Number: 2. This is the second issue of the year 2009 and 10th anniversary of TOJDE. In this issue it is published four notes for Editor, 13 articles, 2 reviews. And this time, 28 authors from 8 different countries are placed. These published articles are from Canada, Gana, India, Iran, Malaysia, Pakistan, United Kingdom and Turkey. “Reflective Approach In Teaching Pre-Degree Chemistry” has sent to editor of TOJ...

  16. Editor's note

    Science.gov (United States)

    Umapathy, Siva

    2017-01-01

    This is an editor's note related to the publication 'Biologically active and thermally stable polymeric Schiff base and its metal polychelates: Their synthesis and spectral aspects' by Raza Rasool and Sumaiya Hasnain, which appeared in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 148 (2015) 435-443.

  17. Werner Heisenberg - Life and Work

    CERN Document Server

    2002-01-01

    Werner Heisenberg (centre) with Wolfgang Pauli (left) and Enrico Fermi on Lake Como, September 1927. An exhibition on the life and work of Werner Heisenberg will be on display in the Main Building (Mezzanine) at CERN from 1 - 23 July. The exhibition was produced by the University Archive of Leipzig University (Gerald Wiemers) and the Max-Planck-Institut für Physik in Munich (Helmut Rechenberg) to mark the centenary of Heisenberg's birth in 1901. German theoretical physicist Werner Karl Heisenberg (5 December 1901 - 1 February 1976) was one of the leading scientists of the 20th century. He carried out important work in nuclear and particle physics, but his most significant contribution was to the development of quantum mechanics. He is best known for his uncertainty principle, which restricts the accuracy with which some properties of atoms and particles - such as position and linear momentum - can be determined simultaneously. In 1932 he was awarded the Noble Prize in Physics 'for the creation of q...

  18. Werner Heisenberg - Life and Work

    CERN Multimedia

    2002-01-01

    Werner Heisenberg (centre) with Wolfgang Pauli and Enrico Fermi, 1927. An exhibition on the life and work of Werner Heisenberg will be on display in the Main Building (Mezzanine) at CERN from 1 - 30 July*. German theoretical physicist Werner Karl Heisenberg (1901 - 1976) was one of the leading scientists of the 20th century. Nobel Prize in Physics in 1932, his most significant contribution was to the development of quantum mechanics. He is best known for his uncertainty principle, which restricts the accuracy with which some properties of atoms and particles can be determined simultaneously. Heisenberg was a keen supporter of CERN, and was as the first chairman of CERN's Scientific Policy Committee in October 1954. A related celebration will take place in the TH Amphitheatre (4/3-006), on Thursday 18 July at 16:00. After an introduction from the Director-General Luciano Maiani, his daughter, Barbara Blum, his last postgraduate, Helmut Rechenberg and Valentin Telegdi will evoke memories of the life and work ...

  19. Fnom Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2006-01-01

    Full Text Available Greetings Dear readers of TOJDE, I am pleased to inform you that in the 7th year of TOJDE is appeared as Volume 7, Number: 1 on your screen now as. Very much thanks to all of you once more that we met 21st time, since January 2000. In this issue we published 15 articles, four book reviews, one notes for editor, news and announcements for our readers. And also, we give a place for the Call for Papers to the 4th Special Issue of The Turkish Online Journal of Distance Education (TOJDE (Volume: 7, Number: 2 To be delivered in April 2006. The first article is coming from The Robert Gordon University, Scotland, United Kingdom which is written by Geoff GOOLNIK. He is tutor at Centre for the Enhancement of Learning and Teaching (CELT. His article titled as “Effective Change Management Strategies for Embedding Online Learning within Higher Education and Enabling the Effective Continuing Professional Development of its Academic Staff”. According to Goolnik, “Previous research studies show that those universities wishing to successfully engage in online learning will have to adopt and implement tactics that have the capacity to overcome existing social and cultural constraints. An inclusive, consultative framework needs to be established, and Continuing Professional Development (CPD has been recognized as a key concern that should be addressed here. Second article is dealt with some problems of DE in Nigeria by Dr. Mudasiru Olalere YUSUF in his study which entitled as “Problems and Prospects of Open And Distance Education in Nigeria” He is from Department of Curriculum Studies and Educational Technology, Faculty of Education University of Ilorin, Nigeria. His article explores that the major terms inherent in open and distance education, its potentials, possible factors that may inhibit successful implementation of the programme, and the use of low and high technological tools for its implementation, by adding of his recommendations. And than

  20. Editorial - Letter from the Editors

    Directory of Open Access Journals (Sweden)

    James Sidanius

    2009-12-01

    Full Text Available This time our focus section deals with the topic of ethnic and racial violence and conflict. We are grateful to our guest editors Robert D. Crutchfield (Universityof Washington, United States and Werner Bergmann (TU Berlin, Germany for putting together an appealing collection of contributions addressing this important field. As usual, our Open Section reflects the enormous breadth of our field, with articles on the theories of Clausewitz and the media’s treatment of rape incidents in kibbutzim.Aside from regular activities, the IJCV is in the process of migrating to a new content management system. From next year the journal will appear in a new online design and be easier to browse. The address will not change, though. If you have signed up for our news alerts you will receive further information in good time.

  1. Editor Board

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Zhang Anwen:President,Baotou触search Institute of Rare Earths Wang Xintin:Seeretary Generat,Chinese Soeiety of Rare Earths Zhang Hon虹iang:DireetoF, China而re Earth Information Center Chlef Editor:Liu Yue Editor:怕ng粗n Zhang Peiehen ConsUltant: Prof.为ong Bilin:Direeto凡China Rare Earth Offiee Prof.Wang Caifeng:Vice Direeto石China Rare臼rth offiee Prof.Su Wenqing:Viee Direetor General,Chinese Society of Rare Earths Prof.Xiong Jiaqi:Meta【turgist丘Economist CREIC NEWS V0L.11 N0.7,200517125 CN15一1147lTF PUBLISHED MONTH...

  2. From editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2009-07-01

    Full Text Available Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now. This is the third issue ue of the year 2009 and 10th anniversary of TOJDE as Volume 10, Number: 3. In this issue it is published three notes for Editor, 15 articles, 3 book reviews. And this time, 30 authors from 10 different countries are placed in TOJDE. These published articles are from Australia, Bangladesh, Greece, India, Indonesia, Norway, Nigeria, Pakistan, Turkey and USAThe first Notes for editor arrived from Pakistan on “Self-Efficacy Of Formally And Non-Formally Trained Public Sector Teachers” from University of Sargodha, written by Dr. Muhammad Nadeem ANWAR. IN his paper he compares the formally and non-formally trained in-service public sector teachers’ Self-efficacy by based on Five hypotheses which were developed describing no difference in the self-efficacy of formally and non-formally trained teachers to influence decision making, influence school resources, instructional self-efficacy, disciplinary self-efficacy and create positive school climate. The second notes for editor is titled as Changes of Learners’ Socio-Economic Context After Completing A Professional Education From Bangladesh Open University which is written by A. K. M. Iftekhar KHALID, from Bangladesh Open University. In his paper, he tries to elevate the morale of the organizations like BOU in involving more effort for expanding the organization and also to understand how successful these organization in imparting the knowledge and skill and how effectively the students are able to use those knowledge and skill in their professional life which in turn affects the learners’ income and social esteem. T“Use Of Convergent Mobile Technologies For Sustainable Economic Transformation In The Lives Of Small Farmers In Rural India” is the third paper for “Notes for Editor” section of TOJDE’s in this issue. It has written by C.S.H.N.Murthy, Professor in Journalism and Mass Communication

  3. MPS Editor

    Science.gov (United States)

    Mathews, William S.; Liu, Ning; Francis, Laurie K.; OReilly, Taifun L.; Schrock, Mitchell; Page, Dennis N.; Morris, John R.; Joswig, Joseph C.; Crockett, Thomas M.; Shams, Khawaja S.

    2011-01-01

    Previously, it was time-consuming to hand-edit data and then set up simulation runs to find the effect and impact of the input data on a spacecraft. MPS Editor provides the user the capability to create/edit/update models and sequences, and immediately try them out using what appears to the user as one piece of software. MPS Editor provides an integrated sequencing environment for users. It provides them with software that can be utilized during development as well as actual operations. In addition, it provides them with a single, consistent, user friendly interface. MPS Editor uses the Eclipse Rich Client Platform to provide an environment that can be tailored to specific missions. It provides the capability to create and edit, and includes an Activity Dictionary to build the simulation spacecraft models, build and edit sequences of commands, and model the effects of those commands on the spacecraft. MPS Editor is written in Java using the Eclipse Rich Client Platform. It is currently built with four perspectives: the Activity Dictionary Perspective, the Project Adaptation Perspective, the Sequence Building Perspective, and the Sequence Modeling Perspective. Each perspective performs a given task. If a mission doesn't require that task, the unneeded perspective is not added to that project's delivery. In the Activity Dictionary Perspective, the user builds the project-specific activities, observations, calibrations, etc. Typically, this is used during the development phases of the mission, although it can be used later to make changes and updates to the Project Activity Dictionary. In the Adaptation Perspective, the user creates the spacecraft models such as power, data store, etc. Again, this is typically used during development, but will be used to update or add models of the spacecraft. The Sequence Building Perspective allows the user to create a sequence of activities or commands that go to the spacecraft. It provides a simulation of the activities and

  4. Editor's Letter

    Institute of Scientific and Technical Information of China (English)

    ZHAO Hong

    2010-01-01

    @@ Dear readers, National Bureau of Statistics held a regular news conference on Sept.11th last week, releasing the latest economic development in August just as our editors had finished this Issue which provides the main economic indicators for the period of Jan.-July. To keep up with the updates, I pick up some of the most important economic indicators to you to follow up the macro-economic standing in the country.

  5. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2012-04-01

    Full Text Available Dear TOJDE Readers,Welcome to the Volume 13 Number: 2 of TOJDE! In this issue, 7 notes for Editor and 22 articles one book review of 57 authors from 12 different countries have been published. These published articles are from, Barbados, Ethiopia, India, Indonesia, Iran, Nigeria, Pakistan, Russia, Saudi Arabia, Turkey, USA and Zimbabwe.In general, around 13 articles and 4 notes for editors have been published in TOJDE so far. I would like to explain, why this time 22 articles and 8 submissions published in the articles and in notes for Editor Section respectively. First all, you should know that if a submission picks up from 3 TOJDE editors between 4.5 and 9 over all 9 credits, it means that this submission can be published in TOJDE in the coming issue. However, since the publishing priority of the accepted papers belongs to the highest scored ones, submissions which receive a score between 4.5 and 5 or 6 may wait and be archived for publishing later on. TOJDE administration respected this publishing rule up to now. Therefore, some accepted submissions which obtained over 4.5 have not been published up to now. These submissions were waiting for publishing in TOJDE in the future. In this issue, we decided to give them a chance to be published. For this reason, the current issue includes more papers than the previous issues. The 1st Notes for editor arrived from Russia written by Galina ARTYUSHINA and Olga SHEYPAK on Impacting Motivation In The Virtual Classroom. They mentioned that teachers, educational managers and learners must realize that new opportunities are offered by modern on-line communication. A person with basic Internet and Web skills is open to a new world of knowledge, from free Web surfing and self-organized education - through on-line resources and familiarization with Internet culture, its places, sites, search engines etc. - up to a more structured approach. The 2nd notes for editor is titled as “Use Of Libraries In Open And

  6. Letter from the Editors

    Directory of Open Access Journals (Sweden)

    Jamie Allen

    2013-05-01

    Full Text Available With grateful hearts we offer this, the fourth issue of our second volume. The result of months of back-breaking thinking, emailing, looking, clicking, watching, writing and reading, our winter issue is here. The editors could not have done this without your support. We welcome your materials for our future issues as well as your continued contributions. Purchase your copy of our first book from Punctum Books.

  7. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2007-04-01

    Full Text Available I am pleased to inform you that in the 8th year of TOJDE are appeared on your screen now as Volume 8, Number: 2. In this issue we published one notes for Editor, 14 articles, two reviews, news and announcements for our readers. 27 authors from ten different countries are placed in this issue. These published articles are from Australia, Bahrain, Bangladesh; Canada Indonesia, Malaysia, Pakistan, Turkey, UK and USA.

  8. From the Editor

    OpenAIRE

    Ugur demiray

    2008-01-01

    Greetings Dear readers of TOJDE, TOJDE is appeared on your screen now as Volume 9, Number: 2. This is the second issue of the year 2008. In this issue we published 5 notes for Editor, 12 articles, already … reviews and this time 27 authors from twelve different countries are placed. These published articles are from Canada, Bangladesh, Egypt, Ethiopia, Nigeria, Norway, Pakistan, Philippines, South Africa, The United Kingdom, USA and Turkey. “Reflections on screenagers, faculty development an...

  9. From the Editor

    OpenAIRE

    Ugur demiray

    2008-01-01

    Greetings Dear readers of TOJDE, TOJDE is appeared on your screen now as Volume 9, Number: 2. This is the second issue of the year 2008. In this issue we published 5 notes for Editor, 12 articles, already … reviews and this time 27 authors from twelve different countries are placed. These published articles are from Canada, Bangladesh, Egypt, Ethiopia, Nigeria, Norway, Pakistan, Philippines, South Africa, The United Kingdom, USA and Turkey. “Reflections on screenagers, faculty development an...

  10. Editor's Note

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Under the request of Prof. LI Ming, he retired recently from the Editorial Board of this journal. I give here our deep felt thanks to him on behalf of the Editorial Board for his generosity in giving his valuable time and effort. It is my pleasure to introduce BAI Shuo, JIANG Tao, LI Zhongcheng, and YANG Jingan, who join our Editorial Board effective July 2000. Their biographical sketches list their areas of expertise and accomplishments. I look forward to working with them and feel fortunate to be a colleague of these outstanding people. MIN Yinghua, Executive Editor-in-Chief

  11. Werner Kienzle (1936 – 2016)

    CERN Document Server

    2016-01-01

    Werner was born in Wiernsheim, a small town in Baden-Württemberg close to Stuttgart. His childhood was profoundly marked by the war and the death of his father on the German eastern front.   Despite life after the war being difficult for his family, he was very successful in his academic studies and earned a fellowship at the University of Göttingen, where he did his PhD in solid-state physics. Werner joined CERN in 1964 as a post-doc fellow and he remained at the Organization for his entire career in experimental particle physics. Concerned and eager for peace in the tense context of the cold war, he was deeply involved in collaboration with Russian colleagues and participated in experiments in Serpukhov from 1968 to 1972. Back at CERN, his work concentrated on the search for experimental evidence of the presence of quarks in hadrons. He was among the main initiators of the NA3 experiment at the SPS that measured the structure functions of the pions: the results indicated a cro...

  12. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur DEmiray

    2011-01-01

    Full Text Available Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 12, Number: 1. In this issue it is published 4 notes for Editor, 13 articles, 2 book reviews. And this time, 34 authors from 11 different countries are placed. These published articles are from Cayman Islands, Germany, Greece, India, Iran, Malaysia, Pakistan, Turkey, USA and Zimbabwe.The first Notes for editor arrived from USA, written by Kevin YEE and Jace HARGIS. They focused on “SNAPP:Graphing Student Interactions in a Learning Management ystem”. They mentioned that SNAPP works on multiple LMS’s, including BlackBoard, WebCT Vista, WebCT CE, Sakai, Moodle, and Desire2Learn. The software is free to download and requires Internet access to perform its functions.The second notes for editor is titled as “THE DEVELOPMENT OF DISTANCE EDUCATION IN NIGERIA: Challenges and Prospects” which is written by Muyiwa ADEYEMI, from Olabisi Onabanjo University, NIGERIA. In Nigeria, Africa, the introduction of this form of learning programme, is relatively new and therefore pose some challenges to all stakeholders in the education industry. In trying to meet up with the enormous demands for formal education, Nigerian government established some institutions for distance learning. These included the National Teachers Institute (NTI, the National Open University (NOUN among others. Therefore, this paper examined the historical development of this programme and particularly in Nigeria, the theories and philosophies of distance education “Creativity and Teaching Competency of Prospective B.Ed Teachers” is the third paper for “Notes for Editor” section of TOJDE’s in this issue. It has written by F. L. ANTONY GRACIOUS and P. ANNARAJA from St. Xavier’s College of Education (Autonomous Palayamkottai, INDIA. The present study Creativity and Teaching Competency of prospective B.Ed teachers was probed to find the relationship between Creativity and Teaching Competency of

  13. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2009-01-01

    Full Text Available TOJDE is appeared on your screen now as Volume 10, Number: 1. This is the first issue of the year 2009 and 10th anniversary of TOJDE. In this issue it is published four article are in “Notes for Editor Sectio”, 13 articles, 2 reviews. And this time, 26 authors from twelwe different countries are placed. These published articles are from Australia, Botswana, Canada, Italy India, Jordan, Malaysia, Nigeria, Srilanka, USA and Turkey. “Service Learning In Distance Education: Foreign Language Learning Environments” has sent to editor of TOJDE from Turkey and written by Muhlise Coşgun OGEYIK from Trakya University, Faculty of Education Edirne, TURKEY and Emre GUVENDIR from University of California. Their paper provides an overview in general education, in particular foreign language education, can be acknowledged as a lifelong learning process which can be transformed beyond the borders in global sense. Learning a foreign language requires proficiency in four basic skills which are reading, writing, speaking, and listening. Of these skills, speaking and listening are the most daunting tasks for learners and create obstacles when learners of target language do not get the chance of meeting native speakers. Such obstacles can be overwhelmed by integrating certain applications into education process. Service-learning through the internet as a teaching method can be considered one of the most striking one of those applications for foreign language learners. Paper focuses on the benefits of service-learning are discussed and some suggestions are offered for introducing this method in foreign language settings. The second notes for editor is titled as Students’ Opinions On Blended Learning which is written by Meric BALCI and Haluk SORAN from Hacettepe University, Education Faculty, Ankara,Turkey. They mentioned that E-learning was acknowledged by most educators and researchers as a savior, even an only alternative in education field, especially in

  14. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2004-04-01

    Full Text Available Turkish Online Journal of Distance Education-TOJDE April 2004 ISSN 1302-6488 Volume:5 Number:2 -------------------------------------------------------------------------------- From the Editor I am pleased to inform you that Vol.:5, Number:2 issue of The Turkish Online Journal of Distance Education-TOJDE has been issued on the web site http://tojde.anadolu.edu.tr now. TOJDE is meeting with its readers for the 14th time, since 2000 January.First of all I would like to inform you once more that Volume 5 Number:3 will publish as a special theme issue of TOJDE. This issue will be prepare by Patrick Alan DANAHER, Fons NOUWENS, from Learning, Evaluation, Innovation and Development (LEID Centre, within the Division of Teaching and Learning Services, at Central Queensland University (CQU in Australia and Zeynep ERDINC from Anadolu University as a guest co-editors. Call for papers for taht issue finished at 15th March. Now, the selected articles are in reviewing and evaluation phase in process. In this issue, has been given place to two note for editor, eight articles, three book reviews, 9 news, and as being before three links deal with Anadolu University take place in the literature and introducing a journal dealt with DE application. This issue's articles came from Canada, Greece, Turkey and USA (according to alphabetical order.

  15. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2010-04-01

    Full Text Available Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now again after 3 months as Volume 11, Number: 2. This is the second issue of the year 2010. In this issue it is published four Notes for Editor, fourteen articles and four book reviews. And this time, 37 authors from 8 different countries are placed. These published articles are from Greece, Indonesia, Iran, Malaysia, Pakistan, Saudi Arabia, USA and Turkey.Again Kevin YEE & Jace HARGIS have sent a good and short note to editor of TOJDE from USA. Their paper involve on YouTube and Video Quizzes. They mentioned YouTube videos can be employed to introduce a subject, such as framing the context, or simply to pique curiosity. Or, they may be shown after a principle has been taught, and now needs to be applied in a case study and defense the advantages of this type of formative assessment include both increasing the stimuli and subsequent attention of the student, as well as requiring continual engagement, which produces critical information, and allows students to more fully self-regulate their own conceptual understanding, so they can move forward in their learning with an increased level of awareness of what they know and do not know.The second notes for editor is titled as “COMPARATIVE STUDY OF THE USE OF ICT IN ENGLISH TEACHING-LEARNING PROCESSES” which is written by Abbas ZARE-EEand Abbas SHEKAREY, from rhe Universİty of Kashan, Kashan, Iran. They mentioned in their paper to compare the amount and quality of ICT use in English teaching-learning processes among the faculty members of Medical and Non-medical Universities in Kashan, Iran and to explore the dimensions in which the two groups can benefit from one another and from ICT training in this respect. The results of the analyses showed that there was a significant difference in the amount of ICT use among the faculty members of medical and non-medical universities. Results also indicated that there was a significant

  16. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2007-10-01

    Full Text Available Greetings Dear readers of TOJDE, I am pleased to inform you that in the 8th year of TOJDE are appeared on your screen now as Volume 8, Number: 4. Ti is the last issue of the year 2007. As you volume ( Number 3 was the special issue of TOJDE on “Web 2.0 and Social Software in Distance Education” subject. I received many congrulation for this special issue from the subject expert and TOJDE readers. During 6 months I received more than 45 submissions. Some of them rejected by me for the reason that their subjects were not fit for TOJDE’s publishing content strategy, and some of them rejected by TOJDE’s editors. And others can be publish next year’s issues In this issue we published one notes for Editor, 13 articles, already one review (maybe I can update for one or two reviews in due course which I am waiting from my book reviewers, news and announcements for our readers. This time 24 authors from eighth different countries are placed in this issue. These published articles are from Australia, Gana, Indonesia, Malaysia, Nigeria, Pakistan, Turkey, and UK. The first article of this issue is coming from Faculty of Education, Monash University, Victoria, AUSTRALIA. Article is entitled as “Globalization, Distance Education And Hegemonic Futures” and written by Dr. Glenn RUSSELL. He says in his paper that “Available options for distance educators can be understood in terms of instrumental and interpersonal axes that can potentially indicate the relative consideration that can be given to these factors. This approach is suggested as one way to understand available options at a time when there has been an apparent increase in instrumental approaches to distance education at the expense of interpersonal approaches and issues of social justice. While this problem is of concern, it is more appropriate to reflect on the unintended consequences of distance education for society and identify them than it is to uncritically oppose globalisation

  17. Werner Heisenberg (1901-1976)

    Science.gov (United States)

    Yang, Chen Ning

    2013-05-01

    Werner Heisenberg was one of the greatest physicists of all times. When he started out as a young research worker, the world of physics was in a very confused and frustrating state, which Abraham Pais has described1 as: It was the spring of hope, it was the winter of despair using Charles Dickens' words in A Tale of Two Cities. People were playing a guessing game: There were from time to time great triumphs in proposing, through sheer intuition, make-shift schemes that amazingly explained some regularities in spectral physics, leading to joy. But invariably such successes would be followed by further work which reveal the inconsistency or inadequacy of the new scheme, leading to despair...

  18. Soft-tissue mineralization in Werner syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Leone, Antonio; Costantini, Alessandro Maria; Brigida, Raffaela; Antoniol, Onorina Monica; Bonomo, Lorenzo [Universita Cattolica School of Medicine, Department of Radiology, Rome (Italy); Antonelli-Incalzi, Raffaele [Universita Cattolica School of Medicine, Department of Geriatrics, Rome (Italy)

    2005-01-01

    Werner syndrome is a rare autosomal recessive disorder characterized by clinical signs of premature aging, short stature, scleroderma-like skin changes, endocrine abnormalities, cataracts, and an increased incidence of malignancies. We report on a 48-year-old woman with Werner syndrome associated with intracranial meningiomas who had extensive musculoskeletal manifestations including osteoporosis of the extremities, extensive tendinopathy about the ankles, osteomyelitis of the phalanges of the first left toe, abundant soft-tissue calcification, and two dense ossified soft-tissue masses, with cortical bone and trabeculae arising from the posterosuperior aspect of the calcanei and extending into Kager fat pads. A review of previous descriptions of the radiological abnormalities of Werner syndrome indicates that the presence of soft-tissue calcifications has either not been noted or been mentioned only briefly. Moreover, there is no mention of bony masses associated with Werner syndrome in the world literature, and this would appear to be the first report of this kind. (orig.)

  19. Editor's choice

    Directory of Open Access Journals (Sweden)

    Pinder RM

    2012-07-01

    Full Text Available Roger M PinderEditor-In-Chief, Neuropsychiatric Disease and TreatmentSchizophrenia remains one of the most debilitating and intractable illnesses in psychiatry. Despite the availability of effective drug treatment since the beginning of the psychopharmacological era in the early 1960s with the introduction of the first antipsychotic chlorpromazine, the subsequent development of second generation or atypical antipsychotics, and the effectiveness of certain types of psychotherapy, many patients are unresponsive and remain unwell for several years or relapse after apparent response. Only clozapine has proven efficacy in treatment-resistant schizophrenia, but many patients still do not respond. Polypharmacy is common, with many physicians choosing to augment rather than switch medications. Schizophrenia may be in part a neurodevelopmental disorder and involve changes in brain structure, and credence has been given to the idea that the prodromal phase, before overt symptoms have appeared, should already have been addressed with aggressive treatment. Various aspects of schizophrenia and its treatment, as well as the associated use of antipsychotic drugs in the treatment of the manic phase of bipolar disorder and Tourette syndrome, have been covered in the pages of Neuropsychiatric Disease and Treatment during the first half of 2012.

  20. Werner State Structure and Entanglement Classification

    Directory of Open Access Journals (Sweden)

    David W. Lyons

    2012-01-01

    Full Text Available We present applications of the representation theory of Lie groups to the analysis of structure and local unitary classification of Werner states, sometimes called the decoherence-free states, which are states of n quantum bits left unchanged by local transformations that are the same on each particle. We introduce a multiqubit generalization of the singlet state and a construction that assembles these qubits into Werner states.

  1. From the Editor

    OpenAIRE

    Ugur Demiray

    2006-01-01

    Greetings Dear readers of TOJDE, I am pleased to inform you that in the 7th year of TOJDE is appeared on your screen now as Volume 7, Number: 4. Very much thanks to all of you and TOJDE editorial members once more that we managed to publish TOJDE 25th time, since January 2000. In this issue we published one notes for Editor, 13 articles, two reviews, news and announcements for our readers. 20 authors from seven different countries are placed in this issue. These published articles are from Ba...

  2. From the Editor

    OpenAIRE

    Ugur Demiray

    2009-01-01

    Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 10, Number: 4. This is the last issue of the year 2009 and 10th anniversary of TOJDE. In this issue it is published 3 notes for Editor, 13 articles, 4 book reviews. And this time, 33 authors from 13 different countries are placed. These published articles are from Bangladesh, Egypt, India, Iran, KKTC, Lesotho, Lithuania, Malaysia, Pakistan, Romania, United Kingdom, USA and Turkey.“iPhones and Smartphones” has sent ...

  3. From The Editor

    OpenAIRE

    Ugur Demiray

    2013-01-01

    Dear TOJDE Readers, Welcome to the Volume 14 Number: 1 of TOJDE! In this issue, 31 articles of 65 authors from 12 different countries around the world have been published. These published articles are arrived to the TOJDE from Australia, Guyana, India, Indonesia, Iran, Malaysia, Nigeria, Russia, Taiwan, Turkey, USA and Zimba bwe. First all, you should know that if a submission picks up from three TOJDE editors between 4.5 and 9 over all 9 credits, it means that this submission can be publish...

  4. From the Editor

    OpenAIRE

    Editor-in-Chief Prof. Dr. ugur Demiray

    2004-01-01

    First of all I would like to inform you once more that Volume 6 Number:1 will publish as a special theme issue of TOJDE. This issue will be prepare by Steve Wheleer From Plymouth University, The United Kingdom, as a guest editor. This special issues call for papers still announcing again in this issue too. Now, the articles which are arrived to TOJDE, in reviewing and evaluation phase in process. In this issue, has been given place to nine articles, one book review, 10 news, and as b...

  5. From the Editor

    OpenAIRE

    Ugur Demiray

    2006-01-01

    Greetings Dear readers of TOJDE, I am pleased to inform you that in the 7th year of TOJDE is appeared on your screen now as Volume 7, Number: 3. Very much thanks to all of you once more that we met with you 23rd time, since January 2000. In this issue we published one notes for Editor 15 articles like in this issue, three book reviews, news and announcements for our readers. 25 authors from eight different countries are pleaced in this issue. These published articles are from...

  6. From the Editor

    OpenAIRE

    Ugur Demiray

    2006-01-01

    Greetings Dear readers of TOJDE, I am pleased to inform you that in the 7th year of TOJDE is appeared on your screen now as Volume 7, Number: 3. Very much thanks to all of you once more that we met with you 23rd time, since January 2000. In this issue we published one notes for Editor 15 articles like in this issue, three book reviews, news and announcements for our readers. 25 authors from eight different countries are pleaced in this issue. These published articles are from...

  7. From the Editor

    OpenAIRE

    Editor-in-Chief Prof. Dr. ugur Demiray

    2004-01-01

    First of all I would like to inform you once more that Volume 6 Number:1 will publish as a special theme issue of TOJDE. This issue will be prepare by Steve Wheleer From Plymouth University, The United Kingdom, as a guest editor. This special issues call for papers still announcing again in this issue too. Now, the articles which are arrived to TOJDE, in reviewing and evaluation phase in process. In this issue, has been given place to nine articles, one book review, 10 news, and as b...

  8. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2004-01-01

    Full Text Available We all together arrived fifth volume of TOJDE in 2004. This volume is presenting with some some technical development and richer content to its readers. I am pleased to inform you that Vol.:5, Number:1 issue of The Turkish Online Journal of Distance Education-TOJDE has been issued on the web site http://tojde.anadolu.edu.tr TOJDE is meeting with its readers for the 13th time, since 2000 January.First of all I would like to inform you that Volume 5 Number:3 will publish as a theme issue of TOJDE. This issue will be prepare by Patrick Alan DANAHER and Fons NOUWENS as a guest co-editors, from Learning, Evaluation, Innovation and Development (LEID Centre, within the Division of Teaching and Learning Services, at Central Queensland University (CQU in Australia. You will find detailed knowledge in “News Section” of this issue.

  9. from editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2007-07-01

    Full Text Available Greetings Dear Readers of TOJDE, First of all, please accept my excuse for the reason that the first time TOJDE is a few days delayed to reach its readers in its publication life. I am the most responsibility person for this delaying July 2007 issue of TOJDE is on your screen now again. This is a special issue on the theme on “Web 2.0 and Social Software in Distance Education”, as being Vol. 8, No. 3. Preparing of this special issue took nearly eight months, from the beginning to the arrival to your screen. A short story of this special issue is here if you are interested in. First idea and suggestion came from me to my dear colleagues, Dr. Mark J. W. LEE who is from Charles Sturt University, New South Wales, AUSTRALIA and Dr. Hakan G. SENEL from Turkey, who is Director at the Computer Research and Development Center (BAUM of Anadolu University. After, we agreed on the topic all together we started to announcing as a call for paper at many medium, institutions, governmental or non- governmental organizations, experts, and so on. The seven articles and one study (at “notes for Editor” section published in this special issue were written by twenty authors, from 7 different countries include Australia, Italy, The United Kingdom, Turkey and USA. In addition, two book reviews is also published. I would like to express my sincere thanks that goes to each of them, and valuable panelists for this special issue, in the name of my university and TOJDE. I strongly believe that experience gained on this special issue would encourage us and other interested colleagues in the field for the near future. Below you will find short biodata on my valuable guest editors. Mark J. W. LEE is an Adjunct Lecturer with the School of Education, Charles Sturt University, and an Honorary Research Fellow with the School of Information Technology and Mathematical Sciences, University of Ballarat. He was previously a Lecturer in Information Technology in the School of

  10. Editor's note

    Science.gov (United States)

    Courtillot, Vincent

    2015-01-01

    We wish to draw the attention of the readers of Comptes rendus Geoscience to two thematic issues of our companion journals Comptes rendus Physique (volume 16, issue No. 1, 2015, pp. 1-138) and Comptes rendus Mecanique (volume 343, issue No. 2, 2015, pp. 75-178), respectively devoted to "Granular Physics" and to "Mechanics of granular and polycrystalline solids". In particular, the issue of snow avalanches, which is of interest to the community of geoscientists, is widely discussed in these two dossiers.

  11. From Editor

    OpenAIRE

    Ugur Demiray

    2007-01-01

    Greetings Dear readers of TOJDE, I am pleased to inform you that in the 8th year of TOJDE are appeared on your screen now as Volume 8, Number: 4. Ti is the last issue of the year 2007. As you volume ( Number 3 was the special issue of TOJDE on “Web 2.0 and Social Software in Distance Education” subject. I received many congrulation for this special issue from the subject expert and TOJDE readers. During 6 months I received more than 45 submissions. Some of them rejected by me for the reason t...

  12. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2013-07-01

    Full Text Available Dear TOJDE Readers, Welcome to the Volume 14 Number: 3 of TOJDE! In this issue, 17 articles of 28 authors from 9 different countries around the world have been published. These published articles are arrived to the TOJDE from, Greece, India, Iran, Malaysia, Pakistan, Thailand, Turkey and USA. The 1st article is arrived from Greece and written by Evangelia MANOUSOU, Tutor-Counselor and Antonis LIONARAKIS. Their article deals with a documented research in order to create a pedagogical framework for the application of a supplementary distance learning program in the field of environmental education for pupils of primary education, in remote and multi-grade schools of Greece. This prospect has been considered as an interesting idea with multilateral, socio cultural and democratic dimensions, as it could enrich the school and learning environment of children of the outermost regions. In this paper, there are described the planning criteria and the development of a polymorphic pedagogical material for distance learning, under the title: 'Captain SOS, His Bunch and the Moving Island', the needs according to the characteristics of the target group, the choice of learning theories and the determination of the teaching techniques, the specific teaching techniques and the teaching methodology, the structure of the learning material, the characteristics and the structure of the educational software, the categorization of activities, the supplementary learning material. Moreover, there are described the pilot application and the ways of the evaluation. In the 2nd article is mentioned in context, he emergence of video sharing technology and high-speed broadband connectivity initiative offers a great choice for users throughout the world to share videos online. However, most of the video sharing sites are not primarily educational. Therefore, this study intends to introduce a framework in choosing and installing open source products for teachers and students

  13. Editors' Introduction

    Directory of Open Access Journals (Sweden)

    Jurģis Šķilters

    2010-12-01

    Full Text Available The papers published in this volume were presented at the 6th International Symposium of Cognition, Logic and Communication, entitled ‘Formal Semantics and Pragmatics: Discourse, Context, and Models’, taking place at the University of Latvia, Riga, initially scheduled for April 2010.

  14. Editors' Introduction

    OpenAIRE

    2010-01-01

    The papers published in this volume were presented at the 6th International Symposium of Cognition, Logic and Communication, entitled ‘Formal Semantics and Pragmatics: Discourse, Context, and Models’, taking place at the University of Latvia, Riga, initially scheduled for April 2010.

  15. Werner coordination chemistry and neurodegeneration.

    Science.gov (United States)

    Telpoukhovskaia, Maria A; Orvig, Chris

    2013-02-21

    Neurodegenerative diseases are capturing the world's attention as being the next set of diseases we must tackle collectively. Not only are the patients experiencing gradual cognitive and physical decline in most cases, but these diseases are fatal with no prevention currently available. As these diseases are progressive, providing care and symptom treatment for the ageing population is becoming both a medical and a financial challenge. This review discusses how Werner coordination chemistry plays a role in three diseases - those of Alzheimer's, Parkinson's, and prions. Metal ions are considered to be involved in these diseases in part via their propensity to cause toxic aggregation of proteins. First, the coordination of metal ions, with emphasis on copper(II), to metalloproteins that are hallmarks of these diseases - amyloid β, α-synuclein, and prion, respectively - will be discussed. We will present the current understanding of the metal coordination environments created by the amino acids of these proteins, as well as metal binding affinity. Second, a diverse set of examples of rationally designed metal chelators to outcompete this deleterious binding will be examined based on coordination mode and affinity toward bio-relevant metal ions. Overall, this review will give a general overview of protein and metal chelator coordination environments in neurodegenerative diseases.

  16. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2014-04-01

    Full Text Available Dear TOJDE Readers, Welcome to the volume 15 number: 1 of TOJDE, In this issue, 18 articles of 34 authors from 9 different countries around the world have been published. These published articles are arrived to the tojde from, bBangladesh, Brunei, Greece, India, Indonasia, Malaysia, Republic Of Korea, Turkey and USA. The 1st article is arrived from Grecee written by Evangelos Bebetsos and Dimitrios Goulimaris from Department of Physical Education & Sports Science, Democritus University Of Thrace Komotini, Hellas, on “Personal Outcome And Leadership As Defining Factors Of Satisfaction In The Context Of The Course “Arts II: Overview Of Greek Music And Dance” of The Hellenic Open University”. The purpose of this study was twofold: to assess the construct validity of the modified greek version of the “scale of athlete satisfaction” presented by Theodorakis and Bebetsos (2003 in the broader academic research sector and specifically in the field of open and distance learning, and to examine if variables such as sex, age, marital status and prior experience, influence the levels of students’ satisfaction. Participants were 144 students (55 men and 89 women of the Hellenic Open University who participated in the course “arts ii: review of the Greek music and dance”, between the ages of 25 up to 67 years of age (μage=42, sd=7.62. The scale consists of two factors: a personal outcome and b leadership. Results from factor analysis provided evidence for the construct validity of the scale developed by Theodorakis and Bebetsos (2003. Additionally, results indicated differences between the age groups on the factor of “personal outcome” were the youngest age group had the lowest scores among all three and also, results indicated differences on the factor of “leadership”, were men had higher scores than women. Overall, the study underlines the necessity of adaptation and usage of such an instrument in order to inform and educate

  17. From Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2013-10-01

    Full Text Available Dear TOJDE Reade Welcome to the Volume 14 Number: 4 of TOJDE! In this issue, 24 articles of 39 authors from 14 different countries around the world have been published. These published articles are arrived to the TOJDE from, Bengaldesh, Ethiopia, Greece, India, Indonesia, Iran, Malaysia, Pakistan, Romania, Russia, South Africa, Thailand, Turkey, UAE, USA and Zimbawbe The 1st article is arrived from Russia written by Alexander Aleksandrovich RYBANOV, His article titled as “EDUCATEE'S THESAURUS AS AN OBJECT OF MEASURING LEARNED MATERIAL OF THE DISTANCE LEARNING COURSE”, and deals with a monitoring and control over the process of studying the distance learning course are based on solving the problem of making out an adequate integral mark to the educatee for mastering entire study course, by testing results. It is suggested to use the degree of correspondence between educatee's thesaurus and the study course thesaurus as an integral mark for the degree of mastering the distance learning course. Study course thesaurus is a set of the course objects with relations between them specified. The article considers metrics of the study course thesaurus complexity, made on the basis of the graph theory and the information theory. It is suggested to use the amount of information contained in the study course thesaurus graph as the metrics of the study course thesaurus complexity. Educatee's thesaurus is considered as an object of measuring educational material learned at the semantic level and is assessed on the basis of amount of information contained in its graph, taking into account the factors of learning the thesaurus objects. In the 2nd article titled as “SERVANT LEADERSHIP THROUGH DISTANCE LEARNING: A Case Study” is mentioned in context, study explored the influence a distance learning servant leadership course had on the emergency service students’ understanding of leadership. The research study utilized a case study design in order to tell

  18. From Editor

    OpenAIRE

    Ugur Demiray

    2013-01-01

    Dear TOJDE Readers, Welcome to the Volume 14 Number: 3 of TOJDE! In this issue, 17 articles of 28 authors from 9 different countries around the world have been published. These published articles are arrived to the TOJDE from, Greece, India, Iran, Malaysia, Pakistan, Thailand, Turkey and USA. The 1st article is arrived from Greece and written by Evangelia MANOUSOU, Tutor-Counselor and Antonis LIONARAKIS. Their article deals with a documented research in order to create a ped...

  19. From Editor

    OpenAIRE

    Ugur Demiray

    2013-01-01

    Dear TOJDE Readers, Welcome to the Volume 14 Number: 3 of TOJDE! In this issue, 17 articles of 28 authors from 9 different countries around the world have been published. These published articles are arrived to the TOJDE from, Greece, India, Iran, Malaysia, Pakistan, Thailand, Turkey and USA. The 1st article is arrived from Greece and written by Evangelia MANOUSOU, Tutor-Counselor and Antonis LIONARAKIS. Their article deals with a documented research in order to create a ped...

  20. From Editor

    OpenAIRE

    Ugur Demiray

    2013-01-01

    Dear TOJDE Reade Welcome to the Volume 14 Number: 4 of TOJDE! In this issue, 24 articles of 39 authors from 14 different countries around the world have been published. These published articles are arrived to the TOJDE from, Bengaldesh, Ethiopia, Greece, India, Indonesia, Iran, Malaysia, Pakistan, Romania, Russia, South Africa, Thailand, Turkey, UAE, USA and Zimbawbe The 1st article is arrived from Russia written by Alexander Aleksandrovich RYBANOV, His article titled as “EDUCATEE...

  1. From Editor

    OpenAIRE

    Ugur Demiray

    2014-01-01

    Dear TOJDE Readers, Welcome to the volume 15 number: 1 of TOJDE, In this issue, 18 articles of 34 authors from 9 different countries around the world have been published. These published articles are arrived to the tojde from, bBangladesh, Brunei, Greece, India, Indonasia, Malaysia, Republic Of Korea, Turkey and USA. The 1st article is arrived from Grecee written by Evangelos Bebetsos and Dimitrios Goulimaris from Department of Physical Education & Sports Science, Democritus Unive...

  2. From Editor

    OpenAIRE

    Ugur Demiray

    2013-01-01

    Dear TOJDE Reade Welcome to the Volume 14 Number: 4 of TOJDE! In this issue, 24 articles of 39 authors from 14 different countries around the world have been published. These published articles are arrived to the TOJDE from, Bengaldesh, Ethiopia, Greece, India, Indonesia, Iran, Malaysia, Pakistan, Romania, Russia, South Africa, Thailand, Turkey, UAE, USA and Zimbawbe The 1st article is arrived from Russia written by Alexander Aleksandrovich RYBANOV, His article titled as “EDUCATEE...

  3. Editor's Preface

    DEFF Research Database (Denmark)

    Münster-Swendsen, Mia

    2007-01-01

      This volume, the third in the series, contains the proceedings of the conference 'Law before Gratian' and covers a wide range of topics from individual and local studies to broader reflections on the status and function of law in medieval European societies before the scholastic legal 'revolution......' of the later twelfth century. Seeking to broaden our view of what constituted law in this period, the articles examine these earlier developments in their own right and provide new insights into the variety and complexity of early and high medieval approaches to law and jurisprudence. Contributors...

  4. Robust and fragile Werner states in the collective dephasing Robust and fragile Werner states in the collective dephasing

    CERN Document Server

    Li, S B; Li, S B; Xu, J B; Li, Shang-Bin; Xu, Jing-Bo; Li, Shang-Bin; Xu, Jing-Bo

    2005-01-01

    We investigate the concurrence and Bell violation of the Werner or Werner-like states in the presence of collective dephasing. It is shown that the Werner and certain kinds of Werner-like states are robust against the collective dephasing, and some kinds of Werner-like states is fragile and becomes completely disentangled in a finite-time. The threshold time of complete disentanglement of the Werner state is given. The influence of external driving field on the finite-time disentanglement of Werner states is discussed. Finally, we present a simple method to control the stationary state entanglement of two qubits. We investigate the concurrence and Bell violation of the Werner or Werner-like states in the presence of collective dephasing. It is shown that the Werner and certain kinds of Werner-like states are robust against the collective dephasing, and some kinds of Werner-like states is fragile and becomes completely disentangled in a finite-time. The threshold time of complete disentanglement of the Werner ...

  5. Editors page

    Directory of Open Access Journals (Sweden)

    Margarita Barretto

    2007-12-01

    Full Text Available Entregamos o segundo número da Revista Brasileira de Pesquisa em Turismo- RBTur, inaugurada oficialmente com o primeiro número no dia 25 de agosto de 2007, que coincide com importantes datas no relacionamento das pessoas com as viagens e o turismo. Neste dia, em 1768, o Capitão James Cook, empreende sua primeira viagem transoceânica na sua nave Endeavour. No transporte terrestre, em 1910, funda-se a companhia Yellow Cab nos Estados Unidos. No ar, em 1919, inaugura-se a aviação comercial, quando um avião civil (Havilland transporta passageiros de Londres a Paris. É uma data também importante para as mulheres aviadoras; em 1920 Adrienne Bolland será a primeira figura feminina a atravessar de avião o Canal da Mancha e, em 1932, Amélia Earhart realizará o primeiro vôo sem paradas através do território dos Estados Unidos. Finalmente, no espaço, no dia 25 de agosto de 1989, a sonda Voyager 2 chega a Netuno. Também para os novos paradigmas do turismo, como a preservação da natureza, a data é importante, pois marca a criação do Serviço de Parques Nacionais, nos Estados Unidos, em 1916, que servirá de modelo aos demais países do mundo. Precedida de tantas efemérides transcendentes, a nossa revista tem a responsabilidade de deixar para o futuro uma marca de qualidade acadêmica e inovação científica, que pretendemos cumprir apoiados nos excelentes pesquisadores que há no Brasil e nos países vizinhos, assim como aqueles consagrados no primeiro mundo que nos prestigiam com intercâmbios culturais há tantos anos. O primeiro número teve impressionante acolhida, tendo os editores recebido mails elogiosos de todo o país, assim como da Nova Zelândia, do México, da Espanha, da Argentina, entre outros, de cientistas provenientes das mais diversas áreas, refletindo o sucesso da nossa abordagem multidisciplinar sobre o turismo. Neste segundo número, apresentamos estudos inovadores referentes a aspectos simbólicos do turismo

  6. EDITORIAL: Editor's Farewell

    Science.gov (United States)

    Hudson, R. P.

    1989-01-01

    The completion of Volume 26, 1989, marked the end of my tenure as Editor of Metrologia. My association with the journal, its parent body the Comité International des Poids et Mesures, its host organization the Bureau International des Poids et Mesures, the publishers Springer-Verlag and last (but by no means least) the Editorial Board, has been a pleasant one and I trust that the subscribers will have found the product to be generally satisfactory. There have been, it is true, some disappointments along the way and I shall mention two of these while expressing the hope that the new Editor will enjoy a greater success in their regard. First is the question of circulation, which has stayed dangerously low, although the shrinkage has tapered off in the most recent years. Because of the narrow public support, the costs of production are relatively high and this, through a consequently high subscription rate, tends to enshrine the unsatisfactory state of affairs. Modest schemes to broaden the journal's appeal and bring in a wider readership have foundered upon the first step, namely, that of procuring from staff members of the national standards laboratories the hoped-for articles which would discuss the state of the art in delivering the highest-quality measurement services to the public. However, some very interesting and bolder schemes are presently under discussion. I had also hoped to leaven the journal's content a little by regularly appearing articles on the latest developments within the great national laboratories. But, as with technical review articles, it has proven very difficult to find the right authors who can also spare the time, and only a few laboratories have found it possible to collaborate. In taking my leave, it remains for me to thank all the contributors, referees and readers for their support, to express the hope of an ever brighter future for Metrologia and to wish to the new Editor, Dr D A Blackburn, a happy and successful tenure.

  7. On Two-Distillable Werner States

    Science.gov (United States)

    Đoković, Dragomir

    2016-06-01

    We consider bipartite mixed states in a $d\\otimes d$ quantum system. We say that $\\rho$ is PPT if its partial transpose $1 \\otimes T (\\rho)$ is positive semidefinite, and otherwise $\\rho$ is NPT. The well-known Werner states are divided into three types: (a) the separable states (the same as the PPT states); (b) the one-distillable states (necessarily NPT); and (c) the NPT states which are not one-distillable. We give several different formulations and provide further evidence for validity of the conjecture that the Werner states of type (c) are not two-distillable.

  8. Síndrome de Werner: Dos nuevos casos Werner´S Syndrome: Two New Cases

    Directory of Open Access Journals (Sweden)

    M Palombo

    2010-03-01

    Full Text Available Se comunican dos casos del síndrome de Werner, el primero es un hombre con canicie desde la tercera década de la vida y diabetes mellitus diagnosticada el año pasado. El segundo caso es un hombre con alopecia masculina desde los 30 años y cataratas. Ambos nos consultaron por úlceras muy dolorosas en piernas y tobillos. Se efectúa una revisión del síndrome de Werner.Two cases of Werner´s syndrome are reported. The first case is a man with grey hair since his 30s and diabetes mellitus diagnosed last year. The second case is a man with male alopecia since his 30s and cataracts, both consulted us for extremely painful ulcers in their legs and ankles. A review of the Werner´s syndrome is made.

  9. My favorite editor anywhere

    NARCIS (Netherlands)

    Jong, H.A. de; Kooiker, A.T.

    2004-01-01

    How can off-the-shelf editors be reused in applications that need mature editing support? We describe our editor multiplexer which enables interactive, application guided editing sessions using e.g. GNU Emacs and Vim. At a cost of less than 1 KLOC of editor specific glue code, both IDE builders and

  10. From the Editor

    Directory of Open Access Journals (Sweden)

    Editor-in-Chief Prof. Dr. ugur Demiray

    2004-10-01

    Full Text Available First of all I would like to inform you once more that Volume 6 Number:1 will publish as a special theme issue of TOJDE. This issue will be prepare by Steve Wheleer From Plymouth University, The United Kingdom, as a guest editor. This special issue’s call for papers still announcing again in this issue too. Now, the articles which are arrived to TOJDE, in reviewing and evaluation phase in process. In this issue, has been given place to nine articles, one book review, 10 news, and as being before three links deal with Anadolu University take place in the literature and two journals introduced dealt with DE application. This issue's articles came from Greece, Turkish Republic of North Cyprus, Malaysia, Saudi Arabia, Swaziland, Turkey and USA (according to alphabetical order.

  11. Richard A. Werners forskning i pengeskabelse

    DEFF Research Database (Denmark)

    2016-01-01

    Hvilken rolle spiller penge i samfundsøkonomien og hvilken rolle burde penge spille i den økonomiske videnskab? Det forsker Richard Werner i. Han er professor i økonomi ved Southampton University i England, og her præsenteres fire dele af hans forskning i penge: (1) Hvad foregår der egentlig i en...

  12. Werner Herzogi üksiklased / Kristiina Davidjants

    Index Scriptorium Estoniae

    Davidjants, Kristiina, 1974-

    2002-01-01

    Detsembris toimuvat Pimedate Ööde Filmifestivali laiendatakse ka suvele, et sobivates paikades näidata väärtfilme. Alates 6. juunist näidatakse Katariina kirikus Werner Herzogi (1942) filme. Lähemalt režissöörist

  13. Werner Herzogi üksiklased / Kristiina Davidjants

    Index Scriptorium Estoniae

    Davidjants, Kristiina, 1974-

    2002-01-01

    Detsembris toimuvat Pimedate Ööde Filmifestivali laiendatakse ka suvele, et sobivates paikades näidata väärtfilme. Alates 6. juunist näidatakse Katariina kirikus Werner Herzogi (1942) filme. Lähemalt režissöörist

  14. An Interview with Werner F. Leopold.

    Science.gov (United States)

    Hakuta, Kenji

    A 1983 interview with Werner F. Leopold (1896-1984), a key figure in the study of bilingualism and child language, is presented. An introductory section gives some background to the interview. The discussion itself reviews Leopold's personal and professional background, work, and writing, and focuses largely on the linguistic development of…

  15. International dictionary of geophysics : S. K. Runcorn (editor-in-chief). Pergamon, Oxford, 1967, 2 volumes, 1,728 pp., 730 fig., £ 45.0.0

    NARCIS (Netherlands)

    Manten, A.A.

    1968-01-01

    The reader is informed about a large number of subjects in a generally brief, elucidating manner. No single source contains such a large number of short review articles. That the general framework in which the contributions are contained is weak, is no reflection on the authors, but the editor-in-ch

  16. Transient overexpression of Werner protein rescues starvation induced autophagy in Werner syndrome cells.

    Science.gov (United States)

    Maity, Jyotirindra; Bohr, Vilhelm A; Laskar, Aparna; Karmakar, Parimal

    2014-12-01

    Reduced autophagy may be associated with normal and pathological aging. Here we report a link between autophagy and Werner protein (WRNp), mutated in Werner syndrome, the human premature aging Werner syndrome (WS). WRN mutant fibroblast AG11395 and AG05229 respond weakly to starvation induced autophagy compared to normal cells. While the fusion of phagosomes with lysosome is normal, WS cells contain fewer autophagy vacuoles. Cellular starvation autophagy in WS cells is restored after transfection with full length WRN. Further, siRNA mediated silencing of WRN in the normal fibroblast cell line WI-38 results in decreased autophagy and altered expression of autophagy related proteins. Thus, our observations suggest that WRN may have a role in controlling autophagy and hereby cellular maintenance.

  17. Boerhaave: Author and Editor *

    Science.gov (United States)

    Lindeboom, G. A.

    1974-01-01

    The many facets of Herman Boerhaave's life are presented. He was a renowned teacher, physician, author, and editor. Discussed here are his activities as cataloger of the Vossius Collection, author of books on chemistry, botany, and medicine, and as editor of works by Vesalius and early Greek medical writers. Printing and bookselling in Leiden during Boerhaave's era are described. Images PMID:4596962

  18. From the Editor

    Directory of Open Access Journals (Sweden)

    Neven Vrček

    2014-06-01

    Full Text Available Dear authors, readers and future authors,it is my pleasure to present you the 1st number of the 38th volume of the Journal of Information and Organizational Sciences – JIOS.Please allow me one personal note. This is my last issue as an editor. I started in 2008. and it is time to make some changes. I’ll continue to act as a member of editorial board but I am handling over my editorial duty to new editor Alen Lovrenčić. It was pleasure to work with all authors, reviewers and collaborators and please continue partnership with JIOS because we have high aims which cannot be achieved without dedicated scientific community. I would also like to thank the publishing team of JIOS who helped with many operational issues especially: Bernarda Kos, Goran Hajdin and Darko Grabar. In this issue a selection of 3 original scientific papers, 1 survey paper and 1 preliminary communications has been included, all of which have undergone a rigorous double-blind review process in some cases in several rounds.The constant mission of JIOS is to cover scientific publications from broad area of information sciences and related disciplines and we continuously receive many articles in which authors strive to achieve scientific merit. Our review procedure is very strict but even when we decline papers we try to encourage authors in their future work and motivate them to give better results. That is why we maintain very good relations with our authors and we invite all of you to extend cooperation with JIOS.We hope that the variety of themes will draw the attention of researchers in different fields of information sciences and motivate potential authors to expand the Journal’s thematic scope by other themes that may be of interest to the wider ICT research community. These themes motivate us to continue our work of delivering research results to interested audience. The ICT field is changing rapidly and we are constantly searching for cutting edge articles that open

  19. Bivariate Blending Thiele-Werner's Osculatory Rational Interpolation

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Both the expansive Newton's interpolating polynomial and the Thiele-Werner's interpolation are used to construct a kind of bivariate blending Thiele-Werner's osculatory rational interpolation. A recursive algorithm and its characteristic properties are given. An error estimation is obtained and a numerical example is illustrated.

  20. Immortalization of Werner syndrome and progeria fibroblasts

    Energy Technology Data Exchange (ETDEWEB)

    Saito, H.; Moses, R.E. (Baylor College of Medicine, Houston, TX (USA))

    1991-02-01

    Human fibroblast cells from two different progeroid syndromes, Werner syndrome (WS) and progeria, were established as immortalized cell lines by transfection with plasmid DNA containing the SV40 early region. The lineage of each immortalized cell line was confirmed by VNTR analysis. Each of the immortalized cell lines maintained its original phenotype of slow growth. DNA repair ability of these cells was also studied by measuring sensitivity to killing by uv or the DNA-damaging drugs methyl methansulfonate, bleomycin, and cis-dichlorodiamine platinum. The results showed that both WS and progeria cells have normal sensitivity to these agents.

  1. Guest Editor's Introduction

    Directory of Open Access Journals (Sweden)

    Thomas Brante

    2013-12-01

    Full Text Available The studies presented in this issue of Professions & Professionalism are parts of a larger research program called The Professional Landscape in Sweden. Guest editor Thomas Brante explains why it is of interest to an international audience.

  2. Editors' Fall Picks

    Science.gov (United States)

    Hoffert, Barbara; Heilbrun, Margaret; Kuzyk, Raya; Kim, Ann; McCormack, Heather; Katterjohn, Anna; Burns, Ann; Williams, Wilda

    2008-01-01

    From the fall's cascade of great new books, "Library Journal's" editors select their favorites--a dark rendition of Afghan life, a look at the "self-esteem trap," a celebration of Brooklyn activism, and much more.

  3. EDITORIAL: Message from the Editor

    Science.gov (United States)

    Thomas, Paul

    2009-01-01

    Plasmaphysik, Germany) V. Philipps (Forschungszentrum Juelich, Germany) S. Zweben (Princeton Plasma Physics Laboratory, USA) Y. Hirano (National Institute of Advanced Industrial Science and Technology, Japan) Y. Takase (Tokyo University, Japan) In addition there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion. At the end of this issue we give the full list of all referees for 2008. Our thanks to them! Authors The winner of the 2007 award was Clemente Angioni for the paper entitled `Density response to central electron heating: theoretical investigations and experimental observations in ASDEX Upgrade' (Nucl. Fusion 44 8277-845). The winner of the 2008 Nuclear Fusion award is Todd Evans et al for the paper `Suppression of large edge localized modes with edge resonant magnetic fields in high confinement DIII-D plasmas' (Nucl. Fusion 45 595-607). The awards were presented by the IAEA Deputy Director General, Werner Burkart, and the Chairman of the Board of Editors, Mitsuru Kikuchi, on 16 October 2008 at the 22nd IAEA Fusion Energy Conference in Geneva, Switzerland. Given the topicality of these papers for the ITER design, it is a matter of pride to the journal that the work should be published in Nuclear Fusion. Reviews Like many who have worked for a long time in the field, I still make use of Nuclear Fusion Reviews that go back 20 or 30 years. It is particularly useful, therefore, that the Board of Editors has been working to re-activate the review programme. The first fruits will appear in this issue, in the form of `A review of zonal flow experiments', by Akihide Fujisawa. The special procedures for Reviews should be noted: most specifically that they should normally be commissioned by the Board of Editors. However, not only is the Board of Editors working on a programme but I am sure that they would be pleased to consider suggestions for review subjects. Letters The reputation of Nuclear

  4. ISTP CDF Skeleton Editor

    Science.gov (United States)

    Chimiak, Reine; Harris, Bernard; Williams, Phillip

    2013-01-01

    Basic Common Data Format (CDF) tools (e.g., cdfedit) provide no specific support for creating International Solar-Terrestrial Physics/Space Physics Data Facility (ISTP/SPDF) standard files. While it is possible for someone who is familiar with the ISTP/SPDF metadata guidelines to create compliant files using just the basic tools, the process is error-prone and unreasonable for someone without ISTP/SPDF expertise. The key problem is the lack of a tool with specific support for creating files that comply with the ISTP/SPDF guidelines. There are basic CDF tools such as cdfedit and skeletoncdf for creating CDF files, but these have no specific support for creating ISTP/ SPDF compliant files. The SPDF ISTP CDF skeleton editor is a cross-platform, Java-based GUI editor program that allows someone with only a basic understanding of the ISTP/SPDF guidelines to easily create compliant files. The editor is a simple graphical user interface (GUI) application for creating and editing ISTP/SPDF guideline-compliant skeleton CDF files. The SPDF ISTP CDF skeleton editor consists of the following components: A swing-based Java GUI program, JavaHelp-based manual/ tutorial, Image/Icon files, and HTML Web page for distribution. The editor is available as a traditional Java desktop application as well as a Java Network Launching Protocol (JNLP) application. Once started, it functions like a typical Java GUI file editor application for creating/editing application-unique files.

  5. Molecular Biology and Functions of Carrier Proteins. Annual Symposium (46th) of the Society of General Physiologists held in Woods Hole, Massachusetts on September 10-13, 1992. Volume 48

    Science.gov (United States)

    1993-09-13

    tri-iodothyronine (T3) are of major significance for the intermediarv metabolism of virtually all tissues (DeGroot. 1989: Werner and Ingbar . 1991...evaluation, diagnosis. and treatment of some thyroid pathological conditions (Kendal and Condon. 1969: DeGroot. 1989: Werner and Ingbar . 1991). The 1 TPO...Endocrinology. 114:1090-1098. Werner , S. C., and S. Ingbar . 1991. The Thyroid: A Fundamental and Clinical Text. L. E. Braverman and R. D. Utiger, editors

  6. WERNER SYNDROME: A NEW CASE REPORT

    Directory of Open Access Journals (Sweden)

    Faida Ajili

    2013-10-01

    Full Text Available “Werner’s syndrome” or premature aging syndrome is a rare autosomal recessive genetic disease. It is responsible of several complications related to age, including atherosclerosis and association with cancer. We report the case of a 36 year-old-patient, admitted to department of Internal Medicine of the military hospital of Tunis for suspicion of systemic sclerosis. The patient had all the major signs of Werner syndrome (bilateral cataract, sclerotic skin, “bird face”, baldness, small size, parental consanguinity and 4 minor signs (type 2 diabetes, hypogonadism, squeaky voice, and flat feet. She has also a brother with the same morphotype died at the age of 32 by a myocardial infarction. The current follow-up time is 9 years..

  7. Behavior of Werner states under relativistic boosts

    Science.gov (United States)

    Palge, Veiko; Dunningham, Jacob

    2015-12-01

    We study the structure of maps that Lorentz boosts induce on the spin degree of freedom of a system consisting of two massive spin- 1 / 2 particles. We consider the case where the spin state is described by the Werner state and the momenta are discrete. Transformations on the spins are systematically investigated in various boost scenarios by calculating the orbit and concurrence of the bipartite spin state with different kinds of product and entangled momenta. We confirm the general conclusion that Lorentz boosts cause non-trivial behavior of bipartite spin entanglement. Visualization of the evolution of the spin state is shown to be valuable in explaining the pattern of concurrence. The idealized model provides a basis of explanation in terms of which phenomena in systems involving continuous momenta can be understood.

  8. From Editor vol 11, No.3

    OpenAIRE

    Ugur Demiray

    2010-01-01

    Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 11, Number: 3. In this issue it is published 3 notes for Editor, 12 articles, 2 book reviews. And this time, 32 authors from 10 different countries are placed. These published articles are from Barbados, Ghana, Iran, Malaysia, Pakistan, Spain, Turkey, United Kingdom, UAE and USA.“Developing and Validation A Usability Evaluation Tools For Distance Education Websites:Persian Version” has sent as Notes for editor se...

  9. From Editor vol 11, No.4

    OpenAIRE

    Ugur Demiray

    2010-01-01

    Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 11, Number: 4. In this issue it is published 4 notes for Editor, 12 articles, 2 book and one conference reviews. And this time, 27 authors from 10 different countries are placed. These published articles are from Bangldesh, Greece, India, Israel, Malaysia, Nigeria, Portugal, Singapore, Turkey and USA.The first Notes for editor arrived from USA, written by Kevin YEE and Jace HARGIS. They focused on PREZI: A Differen...

  10. Message from the Editors

    Institute of Scientific and Technical Information of China (English)

    Ann; Rogers

    1997-01-01

    I was very pleased to be invited to be a guest editor for Issue 29 of Teaching English In China.JimBanks,who edited the last two issues,returned to the UK In December.On behalf of all our readersand contributors I would like to thank Jim for his excellent work and wish him and his family ally thebest for 1997.I would also like to thank my co-guest editor,Peter Hare,for undertaking the difficultjob of selecting the best articles from the hundreds we receive.

  11. Reflections on My Werner H. Kirsten Student Internship | Poster

    Science.gov (United States)

    By Nathalie Walker, Guest Writer Editor’s note: This article represents one student’s perspective on her experiences as a Werner H. Kirsten student intern. Failure isn’t just a possibility, it is a certainty; yet failure is what leads you to success. Above all else, that is what I will retain from my experience in the Werner H. Kirsten Student Intern Program (WHK SIP).

  12. Reflections on My Werner H. Kirsten Student Internship | Poster

    Science.gov (United States)

    By Nathalie Walker, Guest Writer Editor’s note: This article represents one student’s perspective on her experiences as a Werner H. Kirsten student intern. Failure isn’t just a possibility, it is a certainty; yet failure is what leads you to success. Above all else, that is what I will retain from my experience in the Werner H. Kirsten Student Intern Program (WHK SIP).

  13. From the Guest Editors

    Directory of Open Access Journals (Sweden)

    Gilly Salmon

    2005-07-01

    Full Text Available From a Distance... Welcome to a few words from your Guest Editor, fellow inhabitants of the third planet from the sun. We offer you a little treat for your computer sore eyes and your typing and texting fingers. We want to share, across cyberspace, not our differences, oh no, but a few of our similarities and understandings as aspirational educators.

  14. Letter to the Editor

    Directory of Open Access Journals (Sweden)

    Pamela Ann Marshall

    2015-12-01

    Full Text Available A letter to the Editor alerting the ASM education community to the passing of Dr. Joseph P. Caruso, influential colleague and co-author of an article included in the scientific citizenship-themed issue of the Journal of Microbiology & Biology Education (JMBE.

  15. Cartas al editor

    OpenAIRE

    Revista Facultad de, Medicina

    2011-01-01

    Nota del editor: en relación con el artículo de la Historia de la Urología en la Universidad Nacional de Colombia, Volumen 41 No.2, se han recibido varias precisiones y aclaraciones de las cuales se extractan los principales apartes.

  16. Editors' Spring Picks

    Science.gov (United States)

    Library Journal, 2011

    2011-01-01

    While they do not represent the rainbow of reading tastes American public libraries accommodate, Book Review editors are a wildly eclectic bunch. One look at their bedside tables and ereaders would reveal very little crossover. This article highlights an eclectic array of spring offerings ranging from print books to an audiobook to ebook apps. It…

  17. Intelectuales y Editores

    Directory of Open Access Journals (Sweden)

    Gustavo Sorá

    2008-10-01

    Full Text Available El intelectual abre ideas, el editor las cierra. El escritor produce textos, el editor impresos. El intelectualescribe pero es el editor quien publica. No por nada, afirman algunos psicólogos, el pensamientoculmina con su publicación. Entre el escritor y el editor se moviliza una energía simbólica y socialsublimada bajo las líneas impresas que llegan al lector. Ese entre-lugar de producción de sentidos, decosmologías, de sociedad que marcó la formación de gran parte de las culturas desde la aparición de laexpresión gráfica de las ideas, permanece como un problema esquivo para la investigación, al menospara la antropología practicada en estas latitudes. Parece una cuestión obturada por el dominanteacúmulo de historias de las ideas, de la literatura, del pensamiento que reactualizan la oposición entreespíritu y materia, estética y sociedad, texto y contexto. Evidencia de ello es la clausura sufrida por lasociología de la literatura, una sub-disciplina tan incómoda para los guardianes del aura del genioliterario nacional.

  18. LETTER TO THE EDITOR: Volume-controlled buckling of thin elastic shells: application to crusts formed on evaporating partially wetted droplets

    Science.gov (United States)

    Head, D. A.

    2006-10-01

    Motivated by observing the buckling of glassy crusts formed on evaporating droplets of polymer and colloid solutions, we numerically model the deformation and buckling of spherical elastic caps controlled by varying the volume between the shell and the substrate. This volume constraint mimics the incompressibility of the unevaporated solvent. Discontinuous buckling is found to occur for sufficiently thin and/or large contact angle shells, and robustly takes the form of a single circular region near the boundary that 'snaps' to an inverted shape, in contrast to the externally pressurized shells case. Scaling theory for shallow shells is shown to approximate well the critical buckling volume, the subsequent enlargement of the inverted region and the contact line force.

  19. From the Editor

    Directory of Open Access Journals (Sweden)

    Željko Hutinski

    2012-07-01

    Full Text Available All the papers in this issue of the JIOS Journal may fit into the Science as Usual categoryand are therefore not going to be dealt with in detail in the introduction. However, for oneof the papers included an exception has been provided, namely the paper Sigma-notationand the equivalence of P and NP classes by Miron Ivanovich Telpiz. The circumstancesleading to its publication in this issue of JIOS are presented by the editors in this preface.It is generally acknowledged that, ever since it was defined by S. Cook over thirty yearsago, P = NP has presented one of the major open problems in computing science andinformation science in general. Whereas, on one hand, this problem presents a formidablechallenge to any scientist dealing with it, its solution, especially in case it should turn out tobe a positive one considering that current technology tends to evolve in a practicaldirection and its overall functioning is conducted implicitly under the assumption of anegative solution would have a major impact on the development of informationtechnology as well as the wider context of human society as a whole. Apart from being putforward in conferences, both positive and negative “solutions” to P = NP problem can beoccasionally found in press, scientific and professional journals. The web page titled “Pversus-NP Page” (see http://www.win.tue.nl/~gwoegi/P-versus-NP.htm provides anexcellent source for this issue. It contains links to papers stating that P = NP, as well asthose contradicting the opposite, i.e., stating that P NP. Furthermore, references are givento Oded Goldreich's rationale behind his decision not to review papers proposing solutionsto P = NP problem and related difficult problems because, in his own words, they “alsoattract the attention of non-experts, and one annoying consequence is a flood of falseclaims of resolutions of these problems” (see http://www.wisdom.weizmann.ac.il/~oded/faq.html. Dr. Goldreich a recognised

  20. Werner Sombart and his reception in Italy

    Directory of Open Access Journals (Sweden)

    Simona Pisanelli

    2015-03-01

    Full Text Available This article intends to focus on the difficulty encountered by Werner Sombart’s works in gaining a hearing in various Italian intellectual circuits. As is well known, Sombart belonged to the German Historical School of economics, sharing with other scholars of that school the same problems in getting his work known in Italy. Our aim is to explain the reason for this hostile reception. First of all, we will analyze the factors which generally hindered the spread of the German Historical School in Italy, recognizing in economists like Francesco Ferrara, Idealists like Benedetto Croce and Marxists like Antonio Labriola some of its strongest opponents. We will dwell on the cases of Gustav Schmoller and Max Weber, in order to give two representative examples of the slow and complicated Italian reception of methodological approaches and analytical perspectives which characterized the scientific experience of the German Historical School. Secondly, we will try to show why Sombart was even less appreciated than other German social scientists, giving the reasons that attracted severe criticism from economists, economic historians and sociologists towards his interdisciplinary approach in the analysis of modern capitalism. Finally, we will show the reasons of the contemporary rediscovery of Sombart and of his works.

  1. Message from the Editor

    Institute of Scientific and Technical Information of China (English)

    Jingkang WANG

    2011-01-01

    @@ As Editor-in-Chief of Frontiers of Chemical Science and Engineering (FCSE), it is my great pleasure to welcome you to the first issue of FCSE of 2011. Chemical science and engineering today and tomorrow is the central, useful and creative science and technology.Chemical science and engineering is fundamental for the quality of life, and it is a driving force for economic and social development.

  2. DOSSIER: Intelectuales y Editores

    Directory of Open Access Journals (Sweden)

    Gustavo Sorá

    2009-04-01

    Full Text Available El intelectual abre ideas, el editor las cierra. El escritor produce textos, el editor impresos. El intelectualescribe pero es el editor quien publica. No por nada, afirman algunos psicólogos, el pensamientoculmina con su publicación. Entre el escritor y el editor se moviliza una energía simbólica y socialsublimada bajo las líneas impresas que llegan al lector. Ese entre-lugar de producción de sentidos, decosmologías, de sociedad que marcó la formación de gran parte de las culturas desde la aparición de laexpresión gráfica de las ideas, permanece como un problema esquivo para la investigación, al menospara la antropología practicada en estas latitudes. Parece una cuestión obturada por el dominanteacúmulo de historias de las ideas, de la literatura, del pensamiento que reactualizan la oposición entreespíritu y materia, estética y sociedad, texto y contexto. Evidencia de ello es la clausura sufrida por lasociología de la literatura, una sub-disciplina tan incómoda para los guardianes del aura del genioliterario nacional.Este dossier busca iluminar esa relación con la certeza de que modela uno de los terrenos másfértiles para repensar el legado de la historia de la cultura en occidente y para generar un basto programade problemas de investigación escasamente explorados por las ciencias sociales y humanas en AméricaLatina, y aplicables al estudio de toda cultura, con o sin escritura.

  3. Enhanced HTML Editor

    OpenAIRE

    Králík, Tomáš

    2012-01-01

    Předmětem této bakalářské práce byl návrh rozšířeného HTML editoru. Čtenář je nejdříve seznámen s jazyky HTML a JavaScript. Následuje přehled existujících WYSIWYG HTML editorů a jejich srovnání. Pro navržení rozšířeného HTML editoru bylo nutné specifikovat nevýhody existujících editorů, ze kterých vznikly požadavky na rozšířený editor. Tento byl následně navržen a implementován v jazyce JavaScript zapomoci knihovny Dojo. Pro testování byly navrženy dvě ukázkové webové aplikace: blog a encyklo...

  4. Guest Editor's introduction

    Science.gov (United States)

    1996-03-01

    Special Issue on Performance Modelling Distributed systems are now accepted as a cost-effective alternative to mainframe computer systems in most commercial environments. Their usage continues to become ever more widespread whilst their complexity is increasing rapidly. The essential advantage of client - server systems in particular is the splitting of an application into a client part, which comprises tasks that are executed locally on workstations such as PCs, and a server part, which executes larger scale computations on a remote mainframe or parallel computer. In this way the end-user is offered great flexibility, using a workstation for its specialist capabilities and user interface which is tailored to use by non-technical staff. However, large calculations, for example access to a large central database, can be hived off, via a network, to a central mainframe which has superior performance and is also most appropriate for managing large volumes of shared data. In short, client - server systems can effectively integrate workstations, and perhaps mid-range systems, with mainframes and supercomputers in a cost-effective and user-friendly way. Many other distributed configurations are also used, for example clusters of networked workstations. Whilst this type of partitioning offers tremendous flexibility to users in a cost-effective way, large distributed systems are highly complex, involving large numbers of components performing tasks concurrently, some of which interact. The choice of components, interconnects and software algorithms is therefore critical and the scale of the problem - often many hundreds of clients, possibly many servers which may be parallel computers themselves and several choices of interconnect - demands a design backed up by formal quantitative performance modelling. This special issue is concerned with the performance evaluation of such distributed systems, many of them client - server systems. A system may be considered as comprising

  5. Oxidative stress and antioxidant response in fibroblasts from Werner and atypical Werner syndromes.

    Science.gov (United States)

    Seco-Cervera, Marta; Spis, Marta; García-Giménez, José Luis; Ibañez-Cabellos, José Santiago; Velázquez-Ledesma, Ana; Esmorís, Isabel; Bañuls, Sergio; Pérez-Machado, Giselle; Pallardó, Federico V

    2014-03-01

    Werner Syndrome (WS, ICD-10 E34.8, ORPHA902) and Atypical Werner Syndrome (AWS, ICD-10 E34.8, ORPHA79474) are very rare inherited syndromes characterized by premature aging. While approximately 90% of WS individuals have any of a range of mutations in theWRN gene, there exists a clinical subgroup in which the mutation occurs in the LMNA/C gene in heterozygosity. Although both syndromes exhibit an age-related pleiotropic phenotype, AWS manifests the onset of the disease during childhood, while major symptoms in WS appear between the ages of 20 and 30. To study the molecular mechanisms of progeroid diseases provides a useful insight into the normal aging process. Main changes found were the decrease in Cu/Zn and Mn SOD activities in the three cell lines. In AWS, both mRNA SOD and protein levels were also decreased. Catalase and glutathione peroxidases decrease, mainly in AWS. Glutaredoxin (Grx) and thioredoxin (Trx) protein expression was lower in the three progeroid cell lines. Grx and Trx were subjected to post-transcriptional regulation, because protein expression was reduced although mRNA levels were not greatly affected in WS. Low antioxidant defense and oxidative stress occur simultaneously in these rare genetic instability disorders at the onset of progeroid disease.

  6. Review of the volume Relatia medic-pacient, editors Liviu OPREA, Cristina GAVRILOVICI, Mihaela- Catalina VICOL, Vasile ASTARASTOAE, published at Polirom Publishing House, Iasi

    Directory of Open Access Journals (Sweden)

    Ana CARAS

    2013-06-01

    Full Text Available The present paper aims at presenting the main ideas of the book “Relatia medic -pacient” written as a result of a post-doctoral project in bioethics. The volume structured in 6 chapters exposes gradually themes such as ethical theories applied in patient -doctor relationship, models of those types of relationships, issue of trust and patient autonomy in the medical care context, medical decisions and communication in patient – doctor relationship. In the economy of a few lines, I will try to expose those aspects that made from this volume a readable, useful and comprehensive one, for both practitioners in medical system but also for persons who are interested by this domain.

  7. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2009-04-01

    Full Text Available Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 10, Number: 2. This is the second issue of the year 2009 and 10th anniversary of TOJDE. In this issue it is published four notes for Editor, 13 articles, 2 reviews. And this time, 28 authors from 8 different countries are placed. These published articles are from Canada, Gana, India, Iran, Malaysia, Pakistan, United Kingdom and Turkey. “Reflective Approach In Teaching Pre-Degree Chemistry” has sent to editor of TOJDE from India and written by B. Venkateswara RAO and D. Samrajya LAKSHMI from Andhra Pradesh University, Their paper involve an investigation of a chemistry teacher in two years intermediate education in Vijayawada, Andhra Pradesh, India. The teacher was successful in his goal of teaching for understanding because he was effective classroom manager and he had strong science content knowledge that enabled him to focus on instructional strategies that facilitated student understanding. He asked appropriate questions, responded to student questions, and used effective cognitive monitoring strategies. The teacher was able to teach effectively because he had adequate content knowledge and pedagogical content knowledge. The second notes for editor is titled as Study Of Learning Styles And Their Roles In The Academic Achievement Of The Students Of Payame Noor University (PNU” which is written by Mahdi Moeni KIA, Ahmad ALIAPOUR and Esmaeil GHADERI, from Human college, Payame Noor University, Tehran, IRAN. Their paper mentioned that most of male students use verbal and solitary learning styles. Most of female student use aural and verbal learning styles. The academic achievement of female students is more than the academic achievement of male students. Among the students of Payame Noor University, those who use visual learning style have the greatest achievement. Students with social, aural, verbal, and solitary learning styles are in the following ranks

  8. A Two-Party Probabilistic Communication Complexity Scenario via Werner States

    Institute of Scientific and Technical Information of China (English)

    XUE Peng; LI Chuan-Feng; GUO Guang-Can

    2001-01-01

    We propose a probabilistic two-party communication complexity scenario with a prior Werner state and analyse the communication abilities of quantum correlations (entanglements) and classical correlations. This process can be used as an entanglement monotone of Werner states.

  9. Editor' s Note

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    @@Since the job as a member of the Editorial Board takes time and effort, following a general rule, members of the Editorial Board of this journal serve on the board for two-year terms of at most two terms. It is my pleasure to introduce Professors Wei Zhao, Jie Wu, Sy-Yen Kuo, who join our Editorial Board effectively from May 2000. Their biographical sketches list their areas of expertise and interests. They will have big shoes to fill, but these new members will be more than up to the task. I feel fortunate to have the privilege of working with them. MIN Yinghua, Executive Editor-in-Chief

  10. Letters to the Editor

    Science.gov (United States)

    1998-03-01

    All the Letters to the Editor in this issue are in the same PostScript or PDF file. Contents Comment on `Magnetic and electric field strengths of high voltage power lines and household appliances' José Luis Giordano Dept. de Ciencia y Tecnología de Materiales y Fluidos, CPSI, Universidad de Zaragoza, Spain Twins paradox S R Carson Norton College, Malton, North Yorkshire, UK On alternative ways of finding the ratio of specific heats of gases Tomas Ficker Physics Department, Technical University of Brno, Czech Republic

  11. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2011-04-01

    Full Text Available Turkish Online Journal of Distance Education-TOJDE April 2011 ISSN 1302-6488 Volume: 12 Number: 2 from EditorGreetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 12, Number: 2. In this issue it is published 4 notes for Editor, 14 articles, 1 book review. And this time, 43 authors from 10 different countries are placed. These published articles are from Austrlia, Bangldesh, India, lndonasia, Iran, Malaysia. Pakistan, Serbia, Turkey and USA.The first Notes for editor arrived from USA, written by Kevin YEE and Jace HARGIS. They focused on Google Moderator and Other Clicker Alternatives. In their notes they mentioned that Students register the device on the company Web site, and the instructor synchronizes the database in order to know which students have registered devices, thus creating accountability for “quizzes” in class. During the lecture, students “vote” for multiple choice answers on screen, and real-time results are displayed (anonymously after the polling is finished, providing instant formative feedback. Another model is for a department or institution to purchase clickers and make available in the classroom. Students pick up the clicker as they enter the room each day and replace when exiting. Using this approach does not allow for direct accountability, unless students are registered to a specific number on the clicker, which is documented and tracked. The second notes for editor is titled as “The Effect Of Virtual Versus Traditional Learning In Achieving Competency-Based Skills” which is written by Leili MOSALANEJAD, Sakine SHAHSAVARI and Mehdi DASTPAK from IRAN. In this quasi-experimental study, 86 freshman nursing students were recruited. Nursing Fundamentals and Skills (including theoretical and practical credits was decided as the teaching course. The theory and practical contents were taught in one group by conventional method (face to face teaching, demonstration on moulage and for another

  12. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2005-09-01

    Full Text Available Greetings Dear readers of TOJDE,I am pleased to inform you that Volume 6, Number: 4 are appearing on your screen now as which is addressed http://tojde.anadolu.edu.tr. Very much thanks to all of you once more that we met 19th time, since January 2000. As we announced in Volume: 6 Number: 3-4 issue, April 2006 issue of TOJDE would published on special issue is to indicate foresight, innovation, and strategy for the future direction of e-learning, more than web-oriented teaching and multipoint videoconferencing, for collaborative, distributed, experiential learning and creation of new knowledge, with youngsters around the world, which hence promote mutual understanding for global peace. Emphasis will be on knowledgeable and inspiring papers (but not limited on the use of GRID networking technology with distributed computer simulation for experiential (hands-on learning through broadband Internet, across national, continental and oceanic boundaries. Subjects are in any fields of e-learning and e-healthcare/telemedicine, in research, case studies, project descriptions, implementation, and reports from the field or book review. I would like to announce for all you, that Volume: 7 Number: 2 will publish as the 4th Special Theme Issue of TOJDE in April 2006. This issue will be prepare by Guest Editor Takeshi UTSUMI, Ph.D., P. E. (Founder and V. P. for Technology and Coordination of Global University System (GUS, USA and Guest Co-Editor Associate Professor Piet KOMMERS (from University of Twente, The Netherlands. In this issue we published 13 articles, three reviews, some news and announcements for our readers. The first article is coming from USA. Author is one of our recent authors; his name is Dr. Scott L. WALKER. This time he wrote on “Modifying Formative Evaluation Techniques For Distance Education Class Evaluation” subject. He indicates in his article that “Post-secondary classes are usually followed by mandatory summative evaluations, yet

  13. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2011-10-01

    Full Text Available Dear readers of TOJDE,TOJDE appears on your screen now as Volume 12, Number: 4. In this issue it publishes 5 notes for Editor, 10 articles, 2 book reviews. And this time, 33 authors from 10 different countries are placed. These published articles are from Bangladesh, Ethiopia, India, Malaysia, Nigeria, Pakistan, Saudi Arabia, Turkey, UAE and USA. The first Notes for editor arrived from USA, written by Kevin YEE and Jace HARGIS. They focused on Google+ is like Twitter in that anyone can follow a given user‘s posts. There is no direct ―friend‖ relationship required to read the posts written by others. However, it also approximates some features of Facebook. Rather than friends sorted into ―lists‖ like in Facebook, Google+ allows users to place feeds into one or more ―circles,‖ the better to monitor (or control the flow of information to and from different audiences. Circles are more intuitive, and more central to the experience, than the Facebook lists. They provide an explicit organizational structure, compared to the less-obvious listing functionality, which feels like an afterthought, found in Facebook. The second notes for editor is titled as ―Learning Community In Online Education‖ which is written by Ziad D. BAGHDADI, Faculty, Riyadh Colleges of Dentistry & Pharmacy, Riyadh, SAUDI ARABIA, Faculty, Damascus University Dental Faculty, Damascus, SYRIA. This paper discusses establishing learning communities early in online education and their helps in bridging distances and differences between physical and virtual worlds of teaching and learning. This article sheds light on the importance of learning communities, and gives readers advices for creating communities that connect, engage, and inspire. Several tools for assessment of learning are provided to appraise online learning communities‘ benefits to learners at all levels. ―Investigating The Effect Of Asynchronous Discussions On Students‘ Learning And Understanding Of

  14. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur demiray

    2008-04-01

    Full Text Available Greetings Dear readers of TOJDE, TOJDE is appeared on your screen now as Volume 9, Number: 2. This is the second issue of the year 2008. In this issue we published 5 notes for Editor, 12 articles, already … reviews and this time 27 authors from twelve different countries are placed. These published articles are from Canada, Bangladesh, Egypt, Ethiopia, Nigeria, Norway, Pakistan, Philippines, South Africa, The United Kingdom, USA and Turkey. “Reflections on screenagers, faculty development and net-supported learning” has been sent from Norway and written by Mike K. MOULTON for Notes for Editor section. He mentioned in his material that strategy for a faculty development program with respect to net-supported learning. Many universities and colleges are struggling with meeting the demands of a rapidly changing world. His reflections are based on experiences from the Norwegian University of Life Sciences. The Second paper has been sent from South Africa, written by Professor Dele Braimoh which is titled as “lifelong learning through mentoring process and its operational dimensions in society”. His paper analyses the varying dimensions of mentoring phenomenon which may be characterized by flexibility of learning process among different groups of people in any given society. He conclude that mentoring is a useful informal and longlife educational process which is not only cost effective, but can also stimulate personal development, increase productivity and improve performance. The third paper on “Development and Validation Process Of A European Language Portfolio Model For Young Learners”, sent by Dr. Ismail Hakki MIRICI from Turkey. He gave a place that various models are being or will be developed and validated in Council of Europe member States depending on the age of learners and national contexts including ELPs for higher and adult education developed by a number of international NGOs. Similarly, every member state should organize

  15. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2008-01-01

    Full Text Available Greetings Dear readers of TOJDE, I am pleased to inform you that in the 8th year of TOJDE finished and TOJDEis appeared on your screen now as Volume 9, Number: 1. This the first issue of the year 2008. As you know the volume 8 Number 3 was the special issue of TOJDE on “Web 2.0 and Social Software in Distance Education” subject. During 6 months I received more than 45 submissions. Some of them rejected by me for the reason that their subjects were not fit for TOJDE’s publishing content strategy and policy, and some of them rejected by TOJDE’s editors. And others can be publish this year’s issues In this issue we published one notes for Editor, 15 articles, already three reviews and this time 24 authors from ten different countries are placed in this issue. These published articles are from Austria, Bangladesh, Egypt, Greece, India, Iran, Jordan, Nigeria, Pakistan and Turkey. GET A SECOND CHANCE TO MAKE A FIRST IMPRESSION: Eradicate the Poverty Level of the Women Farmer in Bangladesh has been sent from Bangladesh Open University and written by Zobaida AKHTER, Ph.D. for Notes for Editor section. She mentioned in her material argues that efforts to promote women in farming are confronted by challenges including poverty, misconception regarding education, training, farming etc. The paper also states that the utilization and development of distance education would effectively address the problem of education and training aimed at rural women. The first article of this issue is coming from Vienna, AUSTRIA, Wegener Center for Climate and Global Change at Graz University, FH Joanneum Graz, and Federal Environment Agency written by Gilbert AHAMER on “Virtual Structures For Mutual Review Promote Understanding Of Opposed Standpoints” . Gilbert metion ih his paper that , in level 2 of SGC students write, review, assess and update standpoints while making use of a web based discussion forum. A statistical analysis of student activities is

  16. From the Editors

    Directory of Open Access Journals (Sweden)

    Jason Harshman

    2016-11-01

    Full Text Available Teaching about globalizations and our interconnectedness with people and places around the world is an essential component of K-12 and higher education, but knowledge about global issues and news is not enough. Increased mobility, digital communication, and cultural hybridity, along with oppression and social injustice require that educators and students not only be able to communicate and collaborate with people different from them, but regularly engage in critical self-reflection around perceived norms and values. In January 2016, the editors of this special issue distributed a call for theoretical, research-based, and practitioner oriented manuscripts on teaching and learning that bring social studies and global citizenship education together. Evidence by the transnational contributions published within this issue of the Journal of Social Studies Education Research, the place of global citizenship education within the social studies is evolving, multifaceted, and not without complications. In short: just how it should be.

  17. Palavras dos editores

    Directory of Open Access Journals (Sweden)

    Nelkis de la Orden Medina

    2005-12-01

    Full Text Available Este número da revista RESI está sendo editado em conjunto por mim e pelo novo editor Jorge Muniz Barreto. A revista tem agora nova sede, o Departamento de Informática e de Estatística da Universidade Federal de Santa Catarina. No que a me diz respeito, tenho a satisfação após estes 4 anos de trabalho de ter contribuído no lançamento e consolidação da revista, a qual considero uma ferramenta útil no âmbito universitário. Agradeço a todos os que fizeram possível a realização deste projeto: aos membros do conselho editorial, ao corpo de avaliadores e principalmente aos autores de trabalhos publicados. Gostaria de agradecer ao novo editor sua excelente disposição para aceitar este desafio e lhe desejo uma gestão editorial de muito sucesso. Tenho a certeza que estamos iniciando uma nova etapa da revista que permitirá um crescimento maior da mesma, na qual continuaremos a colaborar de forma permanente. Campo Largo, dezembro de 2005. Nelkis de la Orden Medina, Editora-Chefe. Repletos de idealismo iniciamos com a edição 6 da Revista Eletrônica de Sistemas de Informação nossa atuação como Editor-Chefe. Esperamos honrar os sucessos obtidos pela revista nos cinco números anteriores, e tornar RESI, cada vez mais útil a seus leitores. Para isto temos planos e contamos além do Conselho Editorial e Revisores, ouvir também a opinião dos leitores de modo informal. Para isto criamos um MSN-Space onde os leitores poderão colocar suas sugestões (operacional e conhecer alguns membros tanto do conselho como revisores. Para vê-lo acessem:http://spaces.msn.com/members/resireveletron Os trabalhos apresentados dão continuidade ao estilo das edições anteriores. São seis artigos, abordando assuntos relacionados à Sistemas de Informação. Estes artigos enriquecem o acervo de trabalhos publicados na revista RESI e mostram o panorama das pesquisas que estão sendo desenvolvidas no Brasil e países amigos. Dentre os planos para o ano

  18. Message from the Editor

    Science.gov (United States)

    Stambaugh, Ronald D.

    2014-01-01

    This last year being an odd numbered year, the pages of Nuclear Fusion saw a large influx of expanded papers from the 2012 Fusion Energy Conference in San Diego. Many papers have focused on the scientific and technical challenges posed by ITER. Contributions are steadily increasing from the new superconducting tokamaks in Asia. The ITER Project continues to move ahead. Construction at the Cadarache site is quite remarkable. Buildings completed include the huge Poloidal Field Coils Winding Facility and the Headquarters building, which has been occupied by the ITER staff. Work is progressing on the Assembly building and the Cryostat Workshop. The base of the tokamak complex is being laid. Besides the construction that is taking place and will take place at the site, components from around the world have to navigate the complex route from Marseilles to the site. A test convoy replicating the dimensions and weights of the most exceptional ITER loads successfully traversed that route in 2013. We are pleased to report that the IAEA and ITER have finalized the agreement for ITER authors to publish papers in Nuclear Fusion . Nuclear Fusion is proud to continue its key role in providing the leading forum for the documentation of scientific progress and exchange of research results internationally toward fusion energy. Refereeing The Nuclear Fusion editorial office appreciates greatly the effort made by our referees to sustain the high quality of the journal. Since January 2005, we have been offering the most active referees over the past year a personal subscription to Nuclear Fusion with electronic access for one year, free of charge. We have excluded our Board Members, Guest Editors of special editions and those referees who were already listed in previous years. The following people have been selected: J.M. Canik, Oak Ridge National Laboratory, USA I.T. Chapman, Culham Centre for Fusion Energy, UK L.-G. Eriksson, Commission of the European Communities, Belgium T. Evans

  19. EDITORIAL: Editor's Introduction

    Science.gov (United States)

    Blackburn, D. A.

    1990-01-01

    Since its first issue in 1965 Metrologia has had just three editors, a history of tenure which suggests that those who hold the post find in it sufficient to interest, occupy, challenge and amuse them. I see no reason to doubt that this happy circumstance will continue and look forward to my own period as editor with the intention of retaining, insofar as I am able to interpret them, the best traditions the journal has established so far. As I take up my editorial duties I have become aware that surrounding Metrologia there is a small community of authors, reviewers and readers on whose support the success of the journal entirely depends. It is a community in which the roles change daily with some of its members engaged, even simultaneously, as reader, reviewer and author. I am well aware that the goodwill extended to me as I enter this community is in no small part due the efforts of the outgoing editor, Dr Ralph Hudson, whose easy, engaging and courteous, yet firm, relationship with authors and reviewers emerges clearly from editorial correspondence. I thank him for that he has done and wish him an active and happy retirement. A short foray into the records of Metrologia shows - in the first editorial - that four main kinds of article were originally envisaged: research articles likely to contribute to progress in fundamental scientific measurements, reports of experiments or techniques of particular importance or originality in the area of secondary measurement, articles concerning the decisions of the Comité International des Poids et Mesures, and review articles. No balance was specified but a priority was assigned to articles dealing with fundamental metrology. Of the four categories, the first two represent the core of Metrologia's activity and largely determine its reputation as a publication. For this reason, editorial implementation of the policy set by the CIPM is mainly exercised through the operation of a reviewing system which is intentionally strict

  20. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2006-07-01

    Full Text Available Greetings Dear readers of TOJDE, I am pleased to inform you that in the 7th year of TOJDE is appeared on your screen now as Volume 7, Number: 3. Very much thanks to all of you once more that we met with you 23rd time, since January 2000. In this issue we published one notes for Editor 15 articles like in this issue, three book reviews, news and announcements for our readers. 25 authors from eight different countries are pleaced in this issue. These published articles are from Bangaldesh, Canada, India, Moldova, Nigeria, Uganda, South Africa, Turkey and USA.The learning organization concept is getting more important in our life day by day at any fields of professionalism, especially for education institution. In this millennium its impotency is increasing in the name of virtual learning environments too. In this issue I gave a place one Notes for Editor from Turkey, Anadolu University. It is written by Assoc. Prof. Dr. Deniz TASCI on the subject that “Online Learning Programs as Learning Organizations: A Case Study of Information Management Programs at Anadolu University, Turkey”. She indicates in her notes that the results of a study in which facilitators’ attitudes toward effectiveness of various media used in the Information Management Associate Degree Program (IMP of Open Education Faculty at Anadolu University, Turkey. The study has shown that textbooks are not viewed as efficient as multimedia programs and web environments by facilitators although they indicate that textbooks should still be used in online courses. The participants also found multimedia programs distributed on CDs more effective than the web environments. The first article of this issue is coming from National Open University of Nigeria, which is written by Olugbenga David OJO and Felix Kayode OLAKULEIN. Their article titled as “The Place of Multiple Intelligence in Achieving the Objectives and Goals of Open and Distance Learning Institutions: a critical analysis

  1. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2009-10-01

    Full Text Available Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 10, Number: 4. This is the last issue of the year 2009 and 10th anniversary of TOJDE. In this issue it is published 3 notes for Editor, 13 articles, 4 book reviews. And this time, 33 authors from 13 different countries are placed. These published articles are from Bangladesh, Egypt, India, Iran, KKTC, Lesotho, Lithuania, Malaysia, Pakistan, Romania, United Kingdom, USA and Turkey.“iPhones and Smartphones” has sent to editor of TOJDE from, USA and written by Kevin YEE & Jace HARGIS from University of the Pacific, California. Their paper involve that the iPhone has become a juggernaut in the United States, with 13 million units sold in 2008 (a 245% increase over 2007 and a further 45 million units expected in 2009 (Elmer-DeWitt, 2009. While iPhone still lags Nokia and RIM internationally, the overall trend toward mobile computing becomes firmer by the day, and it behooves educators to become familiar with the cell phone tools that are relevant for teaching in tomorrow’s -and increasingly “today’s”- classroom.The second notes for editor is titled as “Indian School Teachers’ Perspective On Globalisation of Education A Case Study of Atomic Energy Education Society School Teachers ” which is written by Dr. M. RAJESH and SINDHU. P. NAIR, from Indira Gandhi National Open University. They mentioned in their paper that globalisation has become an enduring reality of our times and more so in the field of education. Teachers are the harbingers of change in the global economy and school teachers have a major role in shaping the attitude of the society towards all social and economic phenomena including that of globalisation. At the Regional Centre of IGNOU situated at Cochin, Kerala an unique training programme was conducted for a year to train school teachers of the Atomic Energy Education Society (AEES one of the elite educational organisations of the country

  2. GUEST EDITORS' INTRODUCTION: Guest Editors' introduction

    Science.gov (United States)

    Coulson, Geoff; de Meer, Jan B.

    1997-03-01

    . Their scheme is embedded in an experimental ATM network with the potential for guaranteed QoS. The system features QoS support mechanisms in both the network and the end systems. Of particular interest is reported experience with a dynamic QoS adaptation protocol implemented in the network and based on video scaling techniques and filtering. In summary, this special issue provides an up to date review of approaches to QoS management and their practical realization. Of course, no claim is made as to comprehensiveness, but the chosen papers do serve as a highly representative sample of current directions in QoS research. The editors are very much obliged to all authors, reviewers and publishers. Without their excellent work, and the contribution of their valuable time this special issue would not have been possible.

  3. Editor profile: Donald H. Eckhardt

    Science.gov (United States)

    For Don Eckhardt, editor of AGU's Geodynamics book series, the scope of subjects appropriate for inclusion in the series is wide. “ The forces implied in the term ‘geodynamics’ operate on this planet on all scales and from the surface deep into the interior,” he says. The articles collected in the red volumes are often united, he suggests, by “an emphasis on common techniques as much as by subject matter.”Like the potential range of topics in the geodynamics series, the breadth of Eckhardt's professional responsibilities is large. As director of the Earth Sciences Division at the Air Force Geophysical Laboratory (AFGL) at Hanscom Air Force Base near Bedford, Mass., he oversees research and development in geodesy, gravity, seismology, geology, and dynamical astronomy. He administers more than 50 outside contracts while actively conducting theoretical and applied research of his own. In the past year, he has become well-known for his proposition that geophysical measurements made by an AFGL team demonstrate the existence and magnitude of two previously undetected fundamental forces in the universe, supplementing electromagnetism, the strong and weak nuclear forces, and Newtonian gravity.

  4. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur DEMIRAY

    2006-04-01

    Full Text Available Greetings Dear readers of TOJDE, I am pleased to inform you that in the 7th year of TOJDE is appeared on your screen now as Volume 7, Number: 1. Very much thanks to all of you once more that we met with you 22nd time, since January 2000. In this issue we published 15 articles like before issue, three book reviews, news and announcements for our readers. And also, we cancelled for the Call for Papers to the 4th Special Issue of The Turkish Online Journal of Distance Education (Volume: 7, Number: 2 which would be delivered in April 2006, instead of this issue, for the reason that have not enough quality papers for publishing on special theme. 36 authors from eight different countries are pleaced in this issue. These published articles are from Bangaldesh, Brasil, Canada, India, Malaysia, Nigeria, Turkey, UK and USA In this issue two articles are dealt with English Language Teacher Training (DELTT Program application in Turkey, by Anadolu University. I gave a place to them as the fist and the last article. The first article of this issue is coming from The Anadolu University, which is written by Belgin AYDIN and T. Volkan YUZER. They are assistant professor at Anadolu’s Education and Open Education Faculty. Their article titled as “Building a Synchronous Virtual Classroom in a Distance English Language Teacher Training (DELTT Program in Turkey”. Their paper reports a synchronous project, “the virtual classroom” prepared for the Distance English Language Teacher Training (DELTT Program. The process of developing the synchronous project and the interface with its specific components were reported with examples and supported by theoretical background from the related literature. The evaluation of the project concludes that the virtual classroom facilitated increased authentic interaction and encouraged learners to become more autonomous. Second article is dealt with internet use adoption among academicians which is written as joint article

  5. Greetings from the Editor

    Directory of Open Access Journals (Sweden)

    Mohammad Hosein Ebrahimzadeh

    2014-09-01

    Full Text Available It is my great honor announcing the promotion of the Archives of Bone and Joint Surgery (ABJS to the level of being available on the PubMed Central site. Being precise, one year ago in September 2013, we published the first issue of the ABJS. Diligently thereafter, we published four subsequent issues with the fifth being in front of you. We set this as our first goal to reach visibility on PubMed striving to raise the quality. We greatly hope that the orthopedics science may be exalted by this voluntary contribution. Hereby, I would like to specially thank to Sarah Post Calhoun and Wayne Jack Logue, from NLM/PMC, for their continuous support, giving direction, and cooperation. I am grateful to my colleagues, Dr Amir Reza Kachooei; the Managing Editor, Dr Ali Moradi; the Editorial Manager and Saeideh Erfani; the Administrative Staff  for their endeavor and being compassionate in this path. I also would like to thank Dr Farshid Bagheri, Dr Ali Birjandinejad, Dr Farzad Omidi-Kashani and Dr Mohsen Mardani-Kivi;  the Deputy Editors  whose continuous efforts from early 2013 has brought the journal to appreciation of scientific excellence.  My sincere thanks to all Editorial Board members and reviewers, who have contributed towards the excellence of the journal by putting efforts and expending their valuable time to evaluate the submitted manuscripts. I send my special thanks to Iranian Knee Surgery Arthroscopy & Sports Traumatology (ISKAST, Iranian Orthopedic Association (IOA, Iranian Society of Shoulder and Elbow Surgeons, and Deputy of Research at Mashhad University of Medical Sciences for their supports. I would like to thank the prime industry sponsers, Osveh Asia Medical Instrument Co. and Tehran Sutures Co. (Zimmer Distributer in Iran, for their financial support. Again I would like to appreciate all contributing authors particularly my outstanding colleagues who wrote an Editorial for us, Prof. Jupiter from Harvard University, Boston, MA

  6. From the Editor

    Directory of Open Access Journals (Sweden)

    Senar, J. C.

    2014-12-01

    Full Text Available In 2001, the Natural History Museum of Barcelona remodelled its journal Miscel·lània Zoològica as Animal Biodiversity and Conservation. One of the aims of this change was to obtain an impact factor, the index that characterises the international ranking of journals. This milestone was reached some years later, in 2012, having published 291 articles that have been cited in impact journals 1,626 times. Two of these papers have been cited more than 100 times. We are now ready to take the next step forward. Our new challenge is to increase our impact factor so that Animal Biodiversity and Conservation is comparable with prestigious international journals in the field. To meet this objective we have assembled a team of editors with international recognition, and we will continue to expand this team over time. We have sought support from the most prestigious Spanish scientific societies and three have accepted the task: the Spanish Society of Ethology, the Spanish Association of Terrestrial Ecology, and the Spanish Society of Evolutionary Biology. These societies have named thematic editors who will help us strengthen their respective disciplines. This means that we will also expand the range of fields covered in the journal in future, interpreting the expression animal biodiversity in the journal´s title in its widest sense. Another front that we have opened to boost Animal Biodiversity and Conservation is the new webpage, remodelled for use as a medium to post our published papers. With this move we not only hope to improve our services to readers but also look towards open access, open access in its broadest conception, offering the journal to scientists, both readers and authors, free of charge. If we want science and the knowledge it generates —produced with public money— to belong to us all, we not only have to enable everyone to read it but we also have to help everyone publish, independently of their economic state. These are difficult

  7. From The Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2013-01-01

    Full Text Available Dear TOJDE Readers, Welcome to the Volume 14 Number: 1 of TOJDE! In this issue, 31 articles of 65 authors from 12 different countries around the world have been published. These published articles are arrived to the TOJDE from Australia, Guyana, India, Indonesia, Iran, Malaysia, Nigeria, Russia, Taiwan, Turkey, USA and Zimba bwe. First all, you should know that if a submission picks up from three TOJDE editors between 4.5 and 9 over all 9 credits, it means that this submission can be published in TOJDE in the coming issue. However, since the publishing priority of the accepted papers belongs to the highest scored ones, submissions which receive a score between 4.5 and 5 or 6 may wait and be archived for publishing later on. TOJDE administration respected this publishing rule up to now. Therefore, some accepted submissions which obtained over 4.5 have not been published up to now. Some of these submissions were waiting for publishing in TOJDE in the future sice 2011. In this issue, we decided to give them a chance to be published. For this reason that becoming end of the year of 2012, more papers for this issue included me than the previous issues. The 1st article arrived from Nigeria and written by Sunday O. ADEGBESAN, from Training and Research Fellow, National Institute for Educational Planning and Administration (NIEPA, on “Effect Of Principals’ Leadership Style On Teachers’ Attitude To Work In Ogun State Secondary Schools, Nigeria ". The purpose of this study was to investigate why some principals prefer to embrace certain leadership styles and the effect of such styles on the teachers’ attitude to work. In the 2nd article is mentioned in their context, especially web-based learning comes forward. Web-based learning can be defined as an information technology-enabled and supported form of distance learning in which the traditional restrictions of classroom learning have disappeared. The Internet can be a useful aid in teaching

  8. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2012-01-01

    Full Text Available Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 13 Number: 1 In this issue it is published 5 notes for Editor, 16articles, 2 books reviews a nd this time, 53 authors from 12 different countries are placed. These published articles are from Azerbaijan, Bangladesh, Greece, Iran, Malaysia, Morocco, Nigeria, Pakistan, Turkey, UAE and USA.The first Notes for editor arrived from USA, written by Kevin YEE and Jace HARGIS. They focused on Simply including a narrative component may provide enough creative ammunition for students to feel that a particular assignment can be more interesting (Clark 2010, if their work is to be wrapped around a narrative format, such as a short story in favor of an essay or formal writing. But there are numerous free technology tools available today that take the process one step further, by injecting different editing options and high-end production values. Students do not merely assemble a story in words. They can now do it primarily with images, and many of the slideshow services online allow for text captions, dynamic transitions, special effects, and relevant animations. Students become videographers and directors as much as they function as storytellers. The slideshow builders thus do a better job than “old fashioned” essay/short story assignments at meeting the need of 21st century students, many of whom arrive at institutions of higher learning with at least an already-ingrained interest in such tools, if not explicit experience.The following note is that a review of existing literature pertaining to servant leadership and faculty development. Specifically, this work discussed delivering servant leadership to online faculty through the utilization of a faculty development program. The idea for this literature review stemmed from the author asking how an online academic administrator could utilize the practice of servant leadership in order to improve the overall online academic

  9. GUEST EDITORS' NOTE

    Directory of Open Access Journals (Sweden)

    Igor Kardum

    2017-05-01

    Full Text Available This issue of Psychological Topics is devoted to one of the central scientific domains for understanding human behavior – personality psychology.  It presents a broad range of contemporary theoretical and empirical contributions regarding personality structure and processes as well as the effects of personality on various outcomes such as sexuality, stress, social attitudes, flow and interpersonal behavior. The articles presented stem from different perspectives including evolutionary, behavioral genetic, physiological, cognitive, developmental and cross-cultural, and show the richness, complexity and diversity of the field. Although the process of editing a journal can be sometimes demanding, we would like to say that we enjoyed it because it was stimulating and challenging and in the end a rewarding experience, mainly thanks to excellent and cooperative authors, who accepted our invitation and contributed to this thematic issue. We would also like to thank Editor-in Chief, Editorial Board and academic reviewers, without whose help this issue would not have been possible.  Igor KardumJasna Hudek-Knezevic

  10. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur DEMIRAY

    2011-08-01

    , Bogazici University, Istanbul,TURKEY. This paper examines the emerging ideas to implement the usage of Second Life as an educational tool in a wide range of subject areas. The majority of the information used to create these 10 pedagogical approaches was derived from a series of participative inquiries, personal observations, formal and informal interviews, and documenting the perceptions of teachers and students using (and trying to use Second Life as an educational tool. Ten pedagogical approaches have emerged thus far. Each section briefing explains the concept, illustrates the idea with examples, and provides implementation suggestions. The sixth article from USA on “USE OF SECOND LIFE IN K-12 AND HIGHER EDUCATION: A Review of Research”, written by Chris INMAN, Vivian H. WRIGHT & Julia A. HARTMAN, from The University of Alabama, USA. This artile is published in Journal of Interactive Online Learning, Volume 9, Number 1, Spring, 2010 and republished by official permission of JIOL Editor-in-Chief’. This study reviewed empirical research conducted in Second Life by educators since Second Life’s launch in 2003. The study’s purpose was to identify how Second Life is being used in both K-12 and higher education. The methodology, findings, and recommendations of 27 research studies were analyzed. Researchers identified potential problems when using Second Life in education, including issues with the Second Life software and hardware requirements, a steep learning curve, and the possibility of students becoming exposed to distractions or inappropriate content. The seventh one is again from USA. On “GENOME ISLAND: A Virtual Science Environment in Second Life”, written by Mary ANNE CLARK, from Texas Wesleyan University, USA”. This article describes the organization and uses of Genome Island, a virtual laboratory complex constructed in Second Life. Genome Island was created for teaching genetics to university undergraduates but also provides a public space where

  11. GUEST EDITOR'S INTRODUCTION: Guest Editor's introduction

    Science.gov (United States)

    Chrysanthis, Panos K.

    1996-12-01

    . The fourth and fifth papers are experience papers describing a workflow management system and a large scale workflow application, respectively. Schill and Mittasch, in `Workflow management systems on top of OSF DCE and OMG CORBA', describe a decentralized workflow management system and discuss its implementation using two standardized middleware platforms, namely, OSF DCE and OMG CORBA. The system supports a new approach to workflow management, introducing several new concepts such as data type management for integrating various types of data and quality of service for various services provided by servers. A problem common to both database applications and workflows is the handling of missing and incomplete information. This is particularly pervasive in an `electronic market' with a huge number of retail outlets producing and exchanging volumes of data, the application discussed in `Information flow in the DAMA project beyond database managers: information flow managers'. Motivated by the need for a method that allows a task to proceed in a timely manner if not all data produced by other tasks are available by its deadline, Russell et al propose an architectural framework and a language that can be used to detect, approximate and, later on, to adjust missing data if necessary. The final paper, `The evolution towards flexible workflow systems' by Nutt, is complementary to the other papers and is a survey of issues and of work related to both workflow and computer supported collaborative work (CSCW) areas. In particular, the paper provides a model and a categorization of the dimensions which workflow management and CSCW systems share. Besides summarizing the recent advancements towards efficient workflow management, the papers in this special issue suggest areas open to investigation and it is our hope that they will also provide the stimulus for further research and development in the area of workflow management systems.

  12. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2006-10-01

    Full Text Available Greetings Dear readers of TOJDE, I am pleased to inform you that in the 7th year of TOJDE is appeared on your screen now as Volume 7, Number: 4. Very much thanks to all of you and TOJDE editorial members once more that we managed to publish TOJDE 25th time, since January 2000. In this issue we published one notes for Editor, 13 articles, two reviews, news and announcements for our readers. 20 authors from seven different countries are placed in this issue. These published articles are from Bangladesh, Germany, Greece, India, Nigeria, South Korea and Turkey.In the “Notes for Editor” section, Dr KURT’s excutive summary is placed via title “Comparative Analysis f Virtual Education Applications”. Dr. Mehmet KURT from Ankara University, Department of Educational Sciences Program of Curriculum and Instruction TURKEY. This summary is his doctorate thesis which is completed on March 2006 at Ankara University. He emphasizes that while in the teaching process they use both synchronous and asynchronous presentation technologies; in order to support course content they use e-mail, web, cd, and course book technologies to provide basic learning environment function; they prefer different environments to cover face to face education needs; they take self learning and collaboration as basis and they take projects and term paper evaluations serious; they mostly prefer multiple choice tests and they usually make virtual courses exams through the internet. Regarding the characteristics of their institutions’ applications, the study group have agreed on mostly to connection and being dependent on connection opportunities. A significant difference between their institutions’ characteristics and the model for developing computer labs, when they had started to provide virtual lessons and presentation technologies used has been found.The first article of this issue is coming from Hellenic Open University, GREECE which is written by Paraskevi VASSALA. In

  13. Editor-in-Chief Editorial

    OpenAIRE

    Reyes Carmona DDS, MSD, PhD, Jessie

    2015-01-01

    The Editor-in-chief discussed briefly regarding the role of Research-Educational Model and academic publications in Dental Education. Moreover, the journal challenges and current issue topics are commented.

  14. Carta del editor

    Directory of Open Access Journals (Sweden)

    Oscar Mauricio Covarrubias-Moreno

    2014-05-01

    Full Text Available Henos aquí con un nuevo número de RIESED. Después de casi un año de ver la luz, y como lo anticipábamos en la carta del editor que acompañaba al número fundacional, hacer una revista electrónica no ha sido una tarea sencilla. Un año más tarde no podemos sino confirmar esa opinión.Gracias al decidido trabajo de los autores, revisores y miembros del equipo editorial hemos podido hacerlo. El proceso de revisión de los artículos ha merecido un cuidado, dedicación y tiempo especiales, que hicieron necesario demorar unos días la fecha de publicación de este tercer número. Asumimos un compromiso con la calidad y estamos convencidos que esa es la única posibilidad de éxito para una revista científica. El contenido y nivel de los artículos disponibles servirá sin duda como incentivo para que los investigadores deseen publicar sus aportes en RIESED.Agradezco especialmente a la Dra. Gloria Rosique Cedillo, Editora Invitada y Coordinadora de este tercer número, así como al investigador César Nicandro Cruz-Rubio, Editor Asociado, apreciados colegas con quienes he tenido el privilegio de trabajar a lo largo de estos meses, y cuya dedicación y esmero han hecho posible RIESED 3.Por otra parte, derivado de nuestro proyecto editorial informo a ustedes de la creación de la Cátedra RIESED. Educación y Sociedad. Esta Cátedra es una iniciativa que la Universidad del Desarrollo Empresarial y Pedagógico ha impulsado en estrecha colaboración con el Grupo de Investigación en Gobierno Administración y Políticas Públicas (GIGAPP del Instituto Universitario de Investigación Ortega y Gasset (IUIOG, Fundación Ortega – Marañón; así como, con la Academia Internacional de Ciencias Político Administrativas y Estudios de Futuro A.C.La Cátedra está concebida como un espacio de diálogo y reflexión interdisciplinario sobre las diferentes temáticas abordadas en RIESED. En el marco de esta iniciativa académica, se invita a los miembros

  15. Editorial: Cartas al Editor

    Directory of Open Access Journals (Sweden)

    Guillermo Llanos

    2006-06-01

    Full Text Available En todas las revistas biomédicas del mundo existe una sección habitual denominada como el título de este editorial y que en Colombia Médica la llamamos correspondencia. Este espacio tiene como objetivo fundamental que los lectores escriban a los autores (investigadores comentando los artículos que se han publicado en números anteriores de la revista. Las cartas son, entonces, breves comentarios de desacuerdo o acuerdo (conceptual, metodológico, interpretativo sobre falencias ubicadas por un lector alerta al tema debatido en cualquiera de las secciones como en los artículos originales, editoriales, revisiones, presentación de casos, etc. publicados previamente en la revista. Las cartas deben permitir el intercambio de opiniones y formas de pensar y analizar los problemas planteados entre los autores y los lectores. En ocasiones una serie de cartas motivadas por un artículo original puede ser tan o más interesante como el artículo que generó la correspondencia. Las cartas son también un formato adecuado para comunicar un hecho novedoso de una observación clínica juiciosa no descrita antes. Un ejemplo de ello es la carta de un gineco-obstetra australiano cuando informó a Lancet los primeros efectos adversos informados de la talidomida. Colombia Médica, a pesar de mantener vigente esta sección, no ha sido muy afortunada en establecer una buena cultura del envío de cartas al editor. Pero últimamente han llegado juiciosas observaciones a las cuales se les ha dado prioridad en su publicación. Toda carta que comenta los hallazgos de un artículo es enviada a los autores para su respuesta, porque ello genera el debate académico buscado, y luego se publican, tanto la carta como su respuesta. El Estilo Vancouver recomienda que la carta y su respuesta deban ser breve, no pasar de dos o tres párrafos y contener sólo cuatro o cinco referencias. En lo posible (a menos que sea indispensable no presentar ni cuadros ni gráficos. El t

  16. A case of Werner's syndrome associated with osteosarcoma.

    Science.gov (United States)

    Murata, K; Hatamochi, A; Shinkai, H; Ishikawa, Y; Kawaguchi, N; Goto, M

    1999-10-01

    We described a case of Werner's syndrome associated with osteosarcoma. A 37-year-old Japanese man was diagnosed as having Werner's syndrome by the presence of juvenile cataracts, skin sclerosis and hyperpigmentation of the feet, high-pitched voice, characteristic bird-like appearance of the face with beak-shaped nose, thinning of the entire skin and hyperkeratoses on soles, hyperlipemia, hyperuricemia, diabetes melitus, and the mutated responsible gene (WRN). He had a 3-month history of a tumor on his left forearm. Histologically, the tumor included four histological patterns; a malignant fibrous histiocytoma-like, a desmoid-like, a dermatofibrosarcoma protuberans-like, and a chondrosarcoma-like pattern. Tumoral osteoid formation was also found in the tumor. Therefore, the tumor was diagnosed as osteosarcoma.

  17. Werner Herzog - saksa kino atleet ja aadlik / Mart Rummo

    Index Scriptorium Estoniae

    Rummo, Mart

    2002-01-01

    Alates 6. juunist näidatakse Katariina kirikus kuuel õhtul algusega kell 22 Werner Herzogi (1942) filme. Väljavõtteid W. Herzogi poolt 1999. aastal Cannes'i festivali järel antud intervjuust, kus juttu ka režissööri suhetest näitleja Klaus Kinskiga, millest kõneleb ka Tallinnas näidatav "Minu armas vaenlane"

  18. Werner Herzog - saksa kino atleet ja aadlik / Mart Rummo

    Index Scriptorium Estoniae

    Rummo, Mart

    2002-01-01

    Alates 6. juunist näidatakse Katariina kirikus kuuel õhtul algusega kell 22 Werner Herzogi (1942) filme. Väljavõtteid W. Herzogi poolt 1999. aastal Cannes'i festivali järel antud intervjuust, kus juttu ka režissööri suhetest näitleja Klaus Kinskiga, millest kõneleb ka Tallinnas näidatav "Minu armas vaenlane"

  19. Herlyn-Werner-Wunderlich syndrome: a rare presentation with pyocolpos

    OpenAIRE

    Cox, Deven; Ching, Brian H.

    2012-01-01

    Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA), also known as Herlyn-Werner-Wunderlich syndrome, is a rare syndrome with only a few hundred reported cases described since 1922. Only a handful of these cases have been associated with pyocolpos. Mullerian duct anomalies have an incidence of 2–3%. While OHVIRA constitutes 0.16–10% of these Mullerian duct anomalies. Symptoms usually present shortly after menarche when hematocolpos develops during menstruation resulting in dysmenorrh...

  20. Werner's Measure on Self-Avoiding Loops and Welding

    Science.gov (United States)

    Chavez, Angel; Pickrell, Doug

    2014-08-01

    Werner's conformally invariant family of measures on self-avoiding loops on Riemann surfaces is determined by a single measure μ_0 on self-avoiding loops in C setminus{0} which surround 0. Our first major objective is to show that the measure μ_0 is infinitesimally invariant with respect to conformal vector fields (essentially the Virasoro algebra of conformal field theory). This makes essential use of classical variational formulas of Duren and Schiffer, which we recast in representation theoretic terms for efficient computation. We secondly show how these formulas can be used to calculate (in principle, and sometimes explicitly) quantities (such as moments for coefficients of univalent functions) associated to the conformal welding for a self-avoiding loop. This gives an alternate proof of the uniqueness of Werner's measure. We also attempt to use these variational formulas to derive a differential equation for the (Laplace transform of) the ''diagonal distribution'' for the conformal welding associated to a loop; this generalizes in a suggestive way to a deformation of Werner's measure conjectured to exist by Kontsevich and Suhov (a basic inspiration for this paper).

  1. From the Editor

    Directory of Open Access Journals (Sweden)

    Bulent Tarman

    2013-11-01

    Full Text Available It is my pleasure to greet you with the new volume of JSSER/SBEAD. Each new volume we publish strengthen our belief in reaching our goals for the future while increasing our hope to build a World where peace, freedom and welfare become the dominant forces. Despite the human tragedy in Syria and Egypt, the decline in terrorist incidents in Turkey and the agreements between Iran and the International community in the region towards more freedom and welfare make us hopeful for establishing the peace, freedom and welfare throughout the world

  2. From the Editor

    OpenAIRE

    Ugur Demiray

    2008-01-01

    Greetings Dear readers of TOJDE, I am pleased to inform you that in the 8th year of TOJDE finished and TOJDEis appeared on your screen now as Volume 9, Number: 1. This the first issue of the year 2008. As you know the volume 8 Number 3 was the special issue of TOJDE on “Web 2.0 and Social Software in Distance Education” subject. During 6 months I received more than 45 submissions. Some of them rejected by me for the reason that their subjects were not fit for TOJDE’s publishing content strate...

  3. From the Editor

    OpenAIRE

    Ugur Demiray

    2005-01-01

    Greetings Dear readers of TOJDE,I am pleased to inform you that Volume 6, Number: 4 are appearing on your screen now as which is addressed http://tojde.anadolu.edu.tr. Very much thanks to all of you once more that we met 19th time, since January 2000. As we announced in Volume: 6 Number: 3-4 issue, April 2006 issue of TOJDE would published on special issue is to indicate foresight, innovation, and strategy for the future direction of e-learning, more than web-oriented teaching and multipoint ...

  4. From the Editor

    OpenAIRE

    Demiray, Ugur

    2006-01-01

    Greetings Dear readers of TOJDE, I am pleased to inform you that in the 7th year of TOJDE is appeared on your screen now as Volume 7, Number: 1. Very much thanks to all of you once more that we met with you 22nd time, since January 2000. In this issue we published 15 articles like before issue, three book reviews, news and announcements for our readers. And also, we cancelled for the Call for Papers to the 4th Special Issue of The Turkish Online Journal of Distance Education (Volume: 7, N...

  5. Nota de los editores

    Directory of Open Access Journals (Sweden)

    Raquel Arias Careaga

    2007-12-01

    Full Text Available Verba Hispanica, sus editores junto con algunos de los amigos, colegas y antiguos alumnos de Julio Rodríguez Puértolas, han decidido elaborar este número especial de la revista dedicado a su obra y a su tdyectoria, no sólo por la dimensión de sus aportaciones al estudio de los hechos literarios como fenómenos propiamente históricos, haciendo de la literatura una herramienta esencial para el conocimiento -y reconocimiento material- del devenir de las sociedades -de las pocas y de sus culturas- como tales fenómenos materiales, sociales e históricos; sino, ]emás, también por el enorme peso de su magisterio, ejercido durante años, tanto en E tados Unidos, como en España, especialmente en la Universidad Autónoma de Madrid, que se ha dirigido siempre a hacer que los estudiantes entiendan el estudio de la literatur como una investigación y un trabajo en el que deben usar no solamente la expresión clara y precisa de sus conclusiones, sino una mirada interdisciplinar a los fenómenos qub son objeto de su estudio. Y finalmente por la larga y frnctífera colaboración directa -e indirecta- con nuestra revista y con nuestro Departamento de Lengua española y literaturas ~spánicas, en Ljubljana. En nuestra memoria quedará siempre su estancia e intervención en el Simposio internacional dedicado al cuarto centenario de la publicación de la primera parte de Don Quijote. Como en la memoria de todos permanecerá el impacto que supuso aquella legendaria Historia social de la literatura española (en colaboración con Iris ¡M. Zavala y Carlos Blanco Aguinaga o el estudio de la literatura fascista española, o esa forma nueva de ver y leer los textos medievales, al Arcipreste de Hita, el Romancero adicional castellano o La, Celestina, en el siglo quince; al propio Cervantes, en la edad conrictiva; o a los autores realistas del diecinueve, Clarín y, sobre todo, Galdós.

  6. From the editors

    NARCIS (Netherlands)

    NN,

    1997-01-01

    We offer apologies to our readers for the delays incurred with the production of this and the previous issue of the Flora Malesiana Bulletin. This is the last issue of the present volume (1992-1997) which is now composed of 8 parts. Time to reflect on some of the changes that were implemented and th

  7. From The Editor

    Directory of Open Access Journals (Sweden)

    T. Volkan YUZER

    2017-04-01

    Full Text Available Dear TOJDE Readers, Welcome to Volume 18, Number 2 of TOJDE, There are 14 articles and 2 book reviews in April 2017 issue. 30 authors write these articles from 9 different countries. These countries are Australia, Brazil, Colombia, Greece, Nigeria, South Africa, Thailand, Turkey and USA.

  8. From the Editor

    Directory of Open Access Journals (Sweden)

    Neven Vrček

    2009-12-01

    Full Text Available Dear readers,I proudly welcome you to Issue 2 of Volume 33 of the Journal of Information and Organizational Sciences.Let me remind you that JIOS is published on the two-issues-per-volume basis, with one volume published annually. One issue of the volume is usually dedicated to CECIIS, the international scientific conference organized and hosted by the Faculty of Organization and Informatics. These special issues of JIOS normally contain a selection of best scientific papers presented at the Conference. The second issue is reserved for scientific papers in the fields of information sciences as well as a range of scientific fields related with information sciences, particularly applied ICT in economics and business.Owing to the efforts of the Editorial Board aimed at including JIOS in a number of relevant databases, JIOS has been steadily increasing its visibility with every new volume. As a result, JIOS is currently being cited in seven databases that cover a variety of scientific topics connected to information sciences, computing and applied ICT.In this issue you will find a selection of several original scientific papers, two preliminary communications and one review paper. We hope that the variety of themes reflects some of your own research interests, thus making the papers inspirational for your future work.As in all my letters addressed to the respected readership of JIOS, I would like to use this opportunity to motivate prospective authors among you, dear readers, to submit papers at www.jios.foi.hr. You are also invited to share with us your comments or critical remarks regarding the papers previously published in the Journal. Your willingness to become a peer-reviewer for submitted papers would be much appreciated as by choosing to do so you would contribute significantly to the rising quality of JIOS.

  9. Palavras do editor

    Directory of Open Access Journals (Sweden)

    Jorge M. Barreto

    2006-12-01

    Full Text Available Estamos completando um ano desde que assumimos a Edição da RESI, e estamos levando a nossos leitores, uma Quarta Edição. Trata-se de uma edição duas vezes especial: primeiro, por ser uma edição dedicada as Aplicações da Informática em Saúde; segundo por ser uma Edição de Natal, e como presente aos leitores, contém uma vasta seleção de artigos.Estas linhas deveriam estar sendo escritas pela Professora Doutora Maria Aparecida Fernandes de Almeida da PUC MINAS, eleita pelo Conselho Editorial como Editora Convidada, honra que havia aceito. Quis o destino que a professora sofresse um acidente de carro, e ela, talvez acreditando em uma rápida recuperação, não renunciou ao cargo. Por outro lado, o Editor Chefe não poderia desconvidar alguém que fora eleita e ficou aguardando, até o momento em que resolveu assumir todo o trabalho, tentando conseguir manter a qualidade desejada e ainda, cumprir a promessa feita aos leitores, de ter este número especial em 2006. A Professora Doutora Maria Aparecida é portando a Editora de Honra deste número, homenagem que prestamos com prazer por sua dedicação ao estudo e às pesquisas das aplicações da Informática em Saúde.Recebemos 36 submissões, e a todos que submeteram, agradecemos. Selecionamos aqueles que os revisores recomendaram como os melhores. Houve um incidente que cabe tornar público por ser um costume que vem se difundindo largamente no meio Universitário. Em uma das submissões, um dos avaliadores detectou cortar e colar de artigos disponíveis na Internet, um deles citado na bibliografia e outro citado em terceiro documento que o mencionava. O total da matéria colada perfazia uma página inteira. Claro que o trabalho foi recusado sendo a razão comunicada aos autores. Este fato ocorreu muitas vezes em trabalhos nos cursos que dei e, em conversa com colegas, verifiquei que este hábito está se generalizando. É política da revista não publicar trabalhos que

  10. R. E. (Ted) Munn — Founding editor; a mini-biography

    Science.gov (United States)

    Taylor, Peter; Thomas, Morley; Truhlar, Ed; Whelpdale, Doug

    1996-02-01

    Ted Munn founded Boundary-Layer Meteorology in 1970 and served as Editor for 75 volumes over a 25 year period. This short article briefly reviews Ted's scientific career with the Atmospheric Environment Service (of Canada), the International Institute for Applied Systems Analysis in Austria and with the Institute of Environmental Studies at the University of Toronto, and as editor of this journal.

  11. From the Editor

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2013-10-01

    Full Text Available Dear TOJDE readers, Welcome to the Volume 14 Number: 4 of TOJDE! In this issue, 24 articles of 39 authors from 14 different countries around the world have been published. These published articles are arrived to the TOJDE from, Bengaldesh, Ethiopia, Greece, India, Indonesia, Iran, Malaysia, Pakistan, Romania, Russia, South Africa, Thailand, Turkey, UAE, USA and Zimbawbe. The 1st article is arrived from Russia written by Alexander Aleksandrovich RYBANOV, His article titled as “EDUCATEE'S THESAURUS AS AN OBJECT OF MEASURING LEARNED MATERIAL OF THE DISTANCE LEARNING COURSE”, and deals with a monitoring and control over the process of studying the distance learning course are based on solving the problem of making out an adequate integral mark to the educatee for mastering entire study course, by testing results. It is suggested to use the degree of correspondence between educatee's thesaurus and the study course thesaurus as an integral mark for the degree of mastering the distance learning course. Study course thesaurus is a set of the course objects with relations between them specified. The article considers metrics of the study course thesaurus complexity, made on the basis of the graph theory and the information theory. It is suggested to use the amount of information contained in the study course thesaurus graph as the metrics of the study course thesaurus complexity. Educatee's thesaurus is considered as an object of measuring educational material learned at the semantic level and is assessed on the basis of amount of information contained in its graph, taking into account the factors of learning the thesaurus objects. In the 2nd article titled as “SERVANT LEADERSHIP THROUGH DISTANCE LEARNING: A Case Study” is mentioned in context, study explored the influence a distance learning servant leadership course had on the emergency service students’ understanding of leadership. The research study utilized a case study design in order to

  12. From the Editor

    OpenAIRE

    Ugur Demiray

    2013-01-01

    Dear TOJDE readers, Welcome to the Volume 14 Number: 4 of TOJDE! In this issue, 24 articles of 39 authors from 14 different countries around the world have been published. These published articles are arrived to the TOJDE from, Bengaldesh, Ethiopia, Greece, India, Indonesia, Iran, Malaysia, Pakistan, Romania, Russia, South Africa, Thailand, Turkey, UAE, USA and Zimbawbe. The 1st article is arrived from Russia written by Alexander Aleksandrovich RYBANOV, His article titled as “EDU...

  13. From the Editor

    OpenAIRE

    Ugur Demiray

    2013-01-01

    Dear TOJDE readers, Welcome to the Volume 14 Number: 4 of TOJDE! In this issue, 24 articles of 39 authors from 14 different countries around the world have been published. These published articles are arrived to the TOJDE from, Bengaldesh, Ethiopia, Greece, India, Indonesia, Iran, Malaysia, Pakistan, Romania, Russia, South Africa, Thailand, Turkey, UAE, USA and Zimbawbe. The 1st article is arrived from Russia written by Alexander Aleksandrovich RYBANOV, His article titled as “EDU...

  14. FROM THE EDITOR

    Directory of Open Access Journals (Sweden)

    Cemil Ozturk

    2014-10-01

    ısı” (Social Studies Teachers’ Perceptions of Tolerance and Feryal Çubukçu “Values Education Through Literary Texts”. These valuable papers have potential to contribute the literature on social studies education. One of the main aims of ASSE was to establish a regular scientific event through which social studies educators from Turkey and abroad get together to share their academic works and ideas. In conjunction with the Faculty of Education of Bolu Abant Izzet Baysal University we are organizing the Fourth International Symposium on Social Studies Education (ISSE in April 2015. The main theme of ISSE the 4th is “Peace Education”. The preference of this theme emphasizes on our hopes and determination for our envision for peace in the late Ottoman geography, in which guns have still been on fire and people have still been shedding tears. And this could be regarded as something similar to the action of Mustafa Kemal Pasha who thought of about the reconstruction of the country after the war and assembled an “Educational Congress” in Ankara to discuss educational issues, during the most difficult days of the War of Independence in 1921. Adopting this approach, we have been considering putting effort to institutionalize the values of democracy, human rights, justice, freedom of thought and freedom of conscience. As a final remark, I would like to thank everyone who contributed to the production of this issue and special thanks to Assoc. Prof. Dr. Erkan Dinç who acted as issue editor. Best regards and hope to meet you in ISSE the 4th…

  15. From the guest editors.

    Science.gov (United States)

    Chowell, Gerardo; Feng, Zhilan; Song, Baojun

    2013-01-01

    Carlos Castilo-Chavez is a Regents Professor, a Joaquin Bustoz Jr. Professor of Mathematical Biology, and a Distinguished Sustainability Scientist at Arizona State University. His research program is at the interface of the mathematical and natural and social sciences with emphasis on (i) the role of dynamic social landscapes on disease dispersal; (ii) the role of environmental and social structures on the dynamics of addiction and disease evolution, and (iii) Dynamics of complex systems at the interphase of ecology, epidemiology and the social sciences. Castillo-Chavez has co-authored over two hundred publications (see goggle scholar citations) that include journal articles and edited research volumes. Specifically, he co-authored a textbook in Mathematical Biology in 2001 (second edition in 2012); a volume (with Harvey Thomas Banks) on the use of mathematical models in homeland security published in SIAM's Frontiers in Applied Mathematics Series (2003); and co-edited volumes in the Series Contemporary Mathematics entitled '' Mathematical Studies on Human Disease Dynamics: Emerging Paradigms and Challenges'' (American Mathematical Society, 2006) and Mathematical and Statistical Estimation Approaches in Epidemiology (Springer-Verlag, 2009) highlighting his interests in the applications of mathematics in emerging and re-emerging diseases. Castillo-Chavez is a member of the Santa Fe Institute's external faculty, adjunct professor at Cornell University, and contributor, as a member of the Steering Committee of the '' Committee for the Review of the Evaluation Data on the Effectiveness of NSF-Supported and Commercially Generated Mathematics Curriculum Materials,'' to a 2004 NRC report. The CBMS workshop '' Mathematical Epidemiology with Applications'' lectures delivered by C. Castillo-Chavez and F. Brauer in 2011 have been published by SIAM in 2013.

  16. From the Editor

    OpenAIRE

    Demiray, Ugur

    2011-01-01

    Dear readers of TOJDE,TOJDE appears on your screen now as Volume 12, Number: 3/2. This issue covers as a Special Issue on “Usage of Second Life Applications in Generally Education and Especially in Distance Education” field. Almost 9 months ago, I was planning to publish a book by agreement with IGI publishing, USA, on “Usage of Second Life Applications in Generally Education and Especially in Distance Education” field. And also recently, I had signed a draft contract with IGI Publishing too....

  17. Editors note, and Dedication

    Directory of Open Access Journals (Sweden)

    Laura Mugnai

    2011-12-01

    Full Text Available This Supplement to volume 50 of Phytopathologia Mediterranea contains original, peer reviewed research papers, prepared from presentations at the 7th International Workshop on Grapevine Trunk Diseases (IWGTD. This Workshop was held in Santa Cruz, Chile, 17–21 January 2010, and was organized by the International Council on Grapevine Trunk Diseases (ICGTD.  Publication of this Supplement has been financially assisted by the International Society for Plant Pathology (ISPP.This Supplementary Issue of Phytopathologia Mediterranea is dedicated to the memory of Dr Luigi Chiarappa, the founder and inspiration of the ICGTD.  

  18. Frof Guest Editors

    Directory of Open Access Journals (Sweden)

    Mark J. W. LEE

    2007-07-01

    the role of universities as content producers for credentialed learning to be questioned, prompting many educators to explore new ways of supporting online learning. The sixth article from Palitha Edirisingha (UK, Chiara Rizzi (Italy, Ming Nie (UK and Libby Rothwell (UK report on a study involving the use of podcasting (Curry, 2004 to provide teaching and learning support for an undergraduate module on English Language and Communication. The findings led to development of a model for integrating podcasts in on-campus blended learning, and which can have potential applications in distance learning contexts. The model is based on three main features of podcasts identified as facilitating student learning: learner choice and flexibility offered by podcasts; tacit knowledge and experience of peers conveyed in discussions; and a sense of informality brought into formal learning. Also from the implementation perspective, Penny de Byl and Janet Taylor (Australia describe a Web 2.0/Web3D hybrid e-learning platform, called the AliveX3D platform, which involves the application of the Web 2.0 ethos to an online 3D virtual environment. The platform and accompanying tools are designed to enable the creation of authentic learning experiences with a large degree of learner control, and to promote collaborative dialogue between learners. The immersion in the 3D worlds enables learners to negotiate meaning based on their own personal cognitive, affective and kinaesthetic experiences rather than relying merely on descriptions of others’ experiences. Last but not least, the “Notes to the Editor” section contains a contribution from Yavuz Akbulut and Mübin Kiyici (Turkey, on the instructional uses of blogs. And two book reviews from the field. We hope you enjoy reading this contributions, and welcome your feedback, rejoinders and reflections on the various articles contained within this special issue. Mark J. W. LEE and Hakan G. SENELGuest Editors, July 2007 Acknowledgements

  19. Experimental preparation of Werner state via spontaneous parametric down-conversion

    CERN Document Server

    Zhang, Y S; Li, C F; Guo, G C; Zhang, Yong-Sheng; Huang, Yun-Feng; Li, Chuan-Feng; Guo, Guang-Can

    2002-01-01

    We present an experiment of preparing Werner state via spontaneous parametric down-conversion and controlled decoherence of photons in this paper. In this experiment two independent BBO (beta-barium borate) crystals are used to produce down-conversion light beams, which are mixed to prepare Werner state.

  20. Nye lektioner i kærlighedens teologi: Werner G. Jeanrond: Kærlighedens teologi

    DEFF Research Database (Denmark)

    Pallesen, Carsten

    2012-01-01

    Anmeldelse af Werner G. Jeanrond, Kærlighedens teologi, Frederiksberg: Aros Forlag 2012 (oversat fra engelsk A Theology of Love, London: T&T Clark 2010)......Anmeldelse af Werner G. Jeanrond, Kærlighedens teologi, Frederiksberg: Aros Forlag 2012 (oversat fra engelsk A Theology of Love, London: T&T Clark 2010)...

  1. WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations.

    NARCIS (Netherlands)

    Friedrich, K.; Lee, L.; Leistritz, D.F.; Nurnberg, G.; Saha, B.; Hisama, F.M.; Eyman, D.K.; Lessel, D.; Nurnberg, P.; Li, C.; Garcia-F-Villalta, M.J.; Kets, C.M.; Schmidtke, J.; Cruz, V.T.; Akker, P.C. van den; Boak, J.; Peter, D.; Compoginis, G.; Cefle, K.; Ozturk, S.; Lopez, N.; Wessel, T. van; Poot, M.; Ippel, P.F.; Groff-Kellermann, B.; Hoehn, H.; Martin, G.M.; Kubisch, C.; Oshima, J.

    2010-01-01

    Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by null mutations at the WRN locus, which codes for a member of the RecQ family of DNA helicases. Since 1988, the International Registry of Werner syndrome had enrolled 130 molecularly confirmed WS cases from among 11

  2. WRN mutations in Werner syndrome patients : genomic rearrangements, unusual intronic mutations and ethnic-specific alterations

    NARCIS (Netherlands)

    Friedrich, Katrin; Lee, Lin; Leistritz, Dru F.; Nuernberg, Gudrun; Saha, Bidisha; Hisama, Fuki M.; Eyman, Daniel K.; Lessel, Davor; Nuernberg, Peter; Li, Chumei; Garcia-F-Villalta, Maria J.; Kets, Carolien M.; Schmidtke, Joerg; Cruz, Vitor Tedim; Van den Akker, Peter C.; Boak, Joseph; Peter, Dincy; Compoginis, Goli; Cefle, Kivanc; Ozturk, Sukru; Lopez, Norberto; Wessel, Theda; Poot, Martin; Ippel, P. F.; Groff-Kellermann, Birgit; Hoehn, Holger; Martin, George M.; Kubisch, Christian; Oshima, Junko

    2010-01-01

    Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by null mutations at the WRN locus, which codes for a member of the RecQ family of DNA helicases. Since 1988, the International Registry of Werner syndrome had enrolled 130 molecularly confirmed WS cases from among 11

  3. Roles of Werner syndrome protein in protection of genome integrity

    DEFF Research Database (Denmark)

    Rossi, Marie L; Ghosh, Avik K; Bohr, Vilhelm A

    2010-01-01

    Werner syndrome protein (WRN) is one of a family of five human RecQ helicases implicated in the maintenance of genome stability. The conserved RecQ family also includes RecQ1, Bloom syndrome protein (BLM), RecQ4, and RecQ5 in humans, as well as Sgs1 in Saccharomyces cerevisiae, Rqh1...... syndrome (WS). WRN is one of the best characterized of the RecQ helicases and is known to have roles in DNA replication and repair, transcription, and telomere maintenance. Studies both in vitro and in vivo indicate that the roles of WRN in a variety of DNA processes are mediated by post...

  4. Bayesian Nash equilibria using extended Werner-like states

    Science.gov (United States)

    Alid-Vaccarezza, M.; Soto, M. E.

    2016-10-01

    We study quantum strategies in games of incomplete information using a formalism of game theory based on multi-sector probability matrix. We analyze an extension of the well-known game of Battle of Sexes using an extended Werner-like state focusing in how its mixedness and entanglement affect the Bayesian Nash payoffs of the player. It is shown that entanglement is needed to outperform classical payoffs but not all entangled states are useful due to the presence of mixedness. A threshold for the mixedness parameter and the minimum entanglement value were found.

  5. 心导管术创始人Werner Forssmann

    Institute of Scientific and Technical Information of China (English)

    周白瑜

    2009-01-01

    @@ Werner Theodor Otto Forssmann教授(1904-1979年,图1),德国人,因发明心导管术获得1956年诺贝尔生理学和医学奖.Forssmann教授毕业于柏林大学医学部,实习期间在Georg Klemperer教授的指导下进行临床实习,师从Rudolph Fick教授学习解削.1929年在柏林市内的Eberswalde医院进行外科实习.

  6. Pyometra and Pregnancy with Herlyn-Werner-Wunderlich Syndrome.

    Science.gov (United States)

    Reis, Maria Inês; Vicente, Ana Patrícia; Cominho, Joana; Gomes, Andrea Sousa; Martins, Luísa; Nunes, Filomena

    2016-12-01

    We describe a Herlyn-Werner-Wunderlich syndrome (HWWS) patient with previous history of infertility who got pregnant without treatment and presented a pyometra in the contralateral uterus throughout the gestational period, despite multiple antibiotic treatments. Due to the uterus' congenital anomaly and the possibility of ascending infection with subsequent abortion, this pregnancy was classified as high-risk. We believe that the partial horizontal septum in the vagina may have contributed to the closure of the gravid uterus cervix, thus ensuring that the pregnancy came to term, with an uneventful vaginal delivery.

  7. Predatory journals recruit fake editor

    OpenAIRE

    Sorokowski, Piotr; Kulczycki, Emanuel; Sorokowska, Agnieszka; Pisanski, Kasia

    2017-01-01

    This article is freely available online at http://www.nature.com/news/predatory-journals-recruit-fake-editor-1.21662 An investigation finds that dozens of academic titles offered ‘Dr Fraud’ — a sham, unqualified scientist — a place on their editorial board. Katarzyna Pisanski and colleagues report.

  8. MOKE "Mark's Own Kanji Editor."

    Science.gov (United States)

    McCaskey, Michael; O'Neill, Patricia A.

    1991-01-01

    Describes the use of MOKE, a basic IBM-compatible Japanese language word processor with a built in Japanese-to-English dictionary that functions as a text editor and also as a preparer and reader of electronic mail in Japanese. (CB)

  9. Letter to Editor

    Directory of Open Access Journals (Sweden)

    Bijan Sadrizadeh

    2009-12-01

    Full Text Available Dear Dr Farhud Editor in Chief   It is a well-known fact that in our daily life we can learn from everything including the good com­munica­tion practices among health professionals.                                                                Delayed communication is a challenge for effective health management in many parts of the world in par­ticular the developing countries.                                                                               Sometimes we learn lessons from a simple exchange of emails between a national public health officer and a WHO program manager. As an example, few weeks ago I sent the following email message to Dr Keiji Fukuda the Special Adviser on Pandemic Influenza to the Director General, World Health Organiza­tion as follows:     Dear Dr Fukuda    First of all I should  congratulate you for your excellent work including valuable information being con­veyed to the Member States through the WHO Site concerning  the most recent developments in the area of the new Influenza A (H1N1 so called Pandemic (H1N1 2009. However, sometimes there is contra­dictory information placed on some of the popular sites of the world which is misleading .As an exam­ple, I would like to refer to the Yahoo News which refers to the interview of the Director General in Paris. I am sure the text published by the (AFP is at least to some extent manipulated. Also the text of the Article is somehow different with the title. This is in contrast with the excellent document placed on the WHO site under the Global Alert and Response (GAR entitled "preparing for the second wave: les­sons from current outbreaks of Pandemic (H1N12009, briefing note 9. Whereas I have no doubt about the fast and extensive spread of the pandemic. I personally disagree with the exaggerations being made by the

  10. From the Editor

    Directory of Open Access Journals (Sweden)

    Neven Vrcek

    2009-06-01

    Full Text Available Dear readers,I am happy  to present you a new  issue of  the Journal of  Information and Organizational Sciences, volume 33, number 1.JIOS is being increasingly seen as a relevant journal in the field of information sciences and applied information and communication technology. Speaking in favour of this statement is the fact that JIOS has been  included  into several new databases – DOAJ (Directory of Open Access Journals, OAIster and Referativny Žurnal – which is information of interest to all our future authors. At present, we are cited in 7 diferent databases, which signifcantly enhances the visibility of the Journal. In  this  issue a  selection of 9 original  scientific papers, 3 preliminary communication articles and 1 review paper has been  included, all of which have undergone rigorous double-blind review. Some of the papers published here were already presented at the CECIIS 2008 conference. The papers  in the current  issue cover a broad area of topics, from programming and web related topics, through algorithm and method proposals,  to economics and applied  linguistics. We hope you will find the papers interesting and challenging for your own research. We encourage you to submit your papers at www.jios.foi.hr, where you can also share with us your recommendations, comments or critical remarks regarding the papers published in previous issues. Your  papers  and  feedback may  prove  invaluable  in  fulfilling  our  ambitions, which  are  very  high indeed, as we have set out to enter some new databases. We would also appreciate your willingness to become a peer-reviewer for submitted papers, and thus give your contribution to the rising quality of JIOS.

  11. From the Editor

    Directory of Open Access Journals (Sweden)

    Neven Vrček

    2010-06-01

    Full Text Available Dear authors, readers and future authors,It is my pleasure to present you the 1st number of the 34th volume of the Journal of Information and Organizational Sciences – JIOS.In this issue a selection of 11 original scientific papers and 2 preliminary communications has been included, all of which have undergone a rigourous double-blind review process. Some of the papers published here were already presented at the CECIIS 2009 Conference held in Varaždin between 23rd and 25th September 2009. These papers were nominated for publishing in JIOS by the chairs of the conference tracks they were presented at on the account of their research quality.As in prior issues of the Journal, this one also comprises papers that cover themes from various ICT fields: semantic web, social networks analysis, LMS interoperability, effective learning environment, game theory, model driven architecture, and other topics in the field of applied information sciences. We hope that the variety of themes will draw the attention of researchers in different ICT fields and motivate potential authors to expand the Journal’s thematic scope by other themes that may be of interest to the wider ICT research community.I would like to use this opportunity to encourage prospective authors among you, dear readers, to submit papers at jios.foi.hr. You are also invited to share with us your comments or critical remarks regarding the papers previously published in the Journal. Further, we would appreciate your willingness to become a peer-reviewer for submitted papers and thus contribute significantly to the rising quality of JIOS.So far JIOS has been indexed in seven well known databases. We are continuously investing a lot of effort to extend the list of databases where JIOS would be cited, in order to make the published papers available to a larger readers’ audience, and give your research a greater impact factor.

  12. From the Editor

    Directory of Open Access Journals (Sweden)

    Neven Vrček

    2012-12-01

    Full Text Available Dear authors, readers and future authors,It is my pleasure to present you the 2nd number of the 36th volume of the Journal of Information andOrganizational Sciences – JIOS.In this issue a selection of 3 original scientic papers, 3 preliminary communications and 1 surveypaper has been included, all of which have undergone a rigorous double-blind review process insome cases in several rounds.As in prior issues of the Journal, this one also comprises papers that cover themes from various ICTelds and related areas: computer algorithms, ERP systems, business process analysis, and otherrelated themes. We hope that the variety of themes will draw the attention of researchers in di€erentelds of information sciences and motivate potential authors to expand the Journal’s thematic scopeby other themes that may be of interest to the wider ICT research community. These themes motivatesus to continue our work of delivering research results to interested audience. We hope that many ofyou who will read the Journal will join us as authors, readers and reviewers and help us to fulll ourmission. The number of submitted papers increases every year giving us opportunity to increase thequality and visibility of JIOS.I would like to use this opportunity to encourage prospective authors among you, dear readers, tosubmit papers at http://jios.foi.hr. You are also invited to share with us your comments or criticalremarks regarding the papers previously published in the Journal. Further, we would appreciate yourwillingness to become a reviewer for submitted papers and thus contribute signicantly to the risingquality of JIOS.So far JIOS has been indexed in nine well known databases. We are continuously investing a lot ofe€ort to extend the list of databases where JIOS would be cited, in order to make the publishedpapers available to a larger readers’ audience, and give your research a greater impact factor.

  13. From the Editor

    Directory of Open Access Journals (Sweden)

    Neven Vrček

    2012-06-01

    Full Text Available Dear authors, readers and future authors,It is my pleasure to present you the 1st number of the 36th volume of the Journal of Information and Organizational Sciences – JIOS.In this issue a selection of 5 original scienti! c papers and 1 survey paper has been included, all of which have undergone a rigorous double-blind review process in some cases in several rounds.As in prior issues of the Journal, this one also comprises papers that cover themes from various ICT fields: computer programming, mobile technologies, symbolic logic in the field of informationsciences, business processes, formal concept analysis, data analysis, management and other related themes. We hope that the variety of themes will draw the attention of researchers in di" erent ICT fields and motivate potential authors to expand the Journal’s thematic scope by other themes that may be of interest to the wider ICT research community.I would like to use this opportunity to encourage prospective authors among you, dear readers, to submit papers at http://jios.foi.hr. You are also invited to share with us your comments or critical remarks regarding the papers previously published in the Journal. Further, we would appreciate your willingness to become a reviewer for submitted papers and thus contribute signi! cantly to the rising quality of JIOS.So far JIOS has been indexed in nine well known databases. We are continuously investing a lot of effort to extend the list of databases where JIOS would be cited, in order to make the published papers available to a larger readers’ audience, and give your research a greater impact factor.

  14. Research Review: Magazine Editors and Editing Practices.

    Science.gov (United States)

    Jolliffe, Lee

    1994-01-01

    Reviews and critiques literature in the subfield of magazine editing research, chiefly biographical studies of individual editors and various types of studies of editorial practices, including surveys, magazine content analyses, and close qualitative examinations of editors' relationships with others. (SR)

  15. EDITORIAL: Message from the Editor Message from the Editor

    Science.gov (United States)

    Thomas, Paul

    2012-01-01

    At the time of writing, the construction of ITER is making, quite literally, visible progress; buildings have gone up, the tokamak pit has been equipped with the seismic pads and pylons have been put in place for the high tension input to the power supplies. Most of the main procurement arrangements have been let and we will see an increasing volume of deliveries to the ITER site over the coming years. In addition, the National Ignition Facility has started full operation and will undoubtedly see important results coming from it in 2012. These projects are important reminders of what a monumental endeavour we are all engaged in and the potential of nuclear fusion to improve the long-term condition of the human race. We can be proud, therefore, that the Nuclear Fusion journal makes such an important contribution to controlled fusion programmes and is maintaining its position as the leading journal in the field. More than 350 articles are submitted each year from over 40 countries. Nuclear Fusion continues to be the most highly cited journal in the field, with an impact factor of 3.303, as listed in the ISI 2010 Science Citation Index. The journal depends on its authors and referees for its success and so I would like to thank them all for their hard work in 2011, which should maintain the level of readership and the citation indices for years to come. I sincerely hope that 2012 will be as good. Refereeing The Nuclear Fusion editorial office understands how much effort is required of our referees. The Editorial Board decided that an expression of thanks to our most loyal referees is appropriate and so, since January 2005, we have been offering the top ten most active referees over the past year a personal subscription to Nuclear Fusion with electronic access for one year, free of charge. This year, three of the top referees have reviewed five manuscripts in the period November 2010 to November 2011 and provided excellent advice to the authors. We have excluded our

  16. From the Editor

    Directory of Open Access Journals (Sweden)

    Neven Vrcek

    2011-12-01

    Full Text Available Dear authors, readers and future authors,It is my pleasure to present you the 2nd number of the 35th volume of the Journal of Information andOrganizational Sciences – JIOS.In this issue a selection of 3 original scientific papers and 1 survey paper have been included, all of which have undergone a rigorous double-blind review process. Some of the papers published here were already presented at the CECIIS 2011 Conference held in Varaždin between 21st and 23rdSeptember 2011. These papers were nominated for publishing in JIOS by the chairs of the conference tracks they were presented at on the account of their research quality.As in prior issues of the Journal, this one also comprises papers that cover themes from various ICT fields: computer programming, symbolic logic in the field of information sciences, business processes, management and other related themes. We hope that the variety of themes will draw the attentionof researchers in different ICT fields and motivate potential authors to expand the Journal’s thematic scope by other themes that may be of interest to the wider ICT research community.I would like to use this opportunity to encourage prospective authors among you, dear readers, to submit papers at jios.foi.hr. You are also invited to share with us your comments or critical remarks regarding the papers previously published in the Journal. Further, we would appreciate yourwillingness to become a peer-reviewed for submitted papers and thus contribute significantly to the rising quality of JIOS.So far JIOS has been indexed in eight well known databases and now this number has risen to nine, adding “Library, Information Science & Technology Abstracts” to the database list. We are continuously investing a lot of effort to extend the list of databases where JIOS would be cited, in order to makethe published papers available to a larger readers’ audience, and give your research a greater impact factor.

  17. From the Editor

    Directory of Open Access Journals (Sweden)

    Neven Vrček

    2013-06-01

    Full Text Available Dear authors, readers and future authors,it is my pleasure to present you the 1st number of the 37th volume of the Journal of Information and Organizational Sciences – JIOS.In this issue a selection of 3 original scientific papers, 1 preliminary communication and 1 survey paper has been included, all of which have undergone a rigorous double-blind review process in some cases in several rounds.As in prior issues of the Journal, this one also comprises papers that cover broad themes from various ICT fields and related areas: software engineering, strategic planning of information systems, knowledge management and quantum computing. We hope that the variety of themes will draw the attention of researchers in different fields of information sciences and motivate potential authors to expand the Journal’s thematic scope by other themes that may be of interest to the wider ICT research community. These themes motivate us to continue our work of delivering research results to interested audience. The ICT field is changing rapidly and we are constantly searching for cutting edge articles that open perspective and motivate further research. We have to notice that future of ICT related research is in interdisciplinary approach and relations with other research domains which is highly emphasized in Horizon 2020 directions. That is why we encourage and promote scientific collaboration across scientific areas that will bring us new interesting articles. We hope that many of you who will read the Journal will join us as authors, readers and reviewers and help us to fulfill our mission. The number of submitted papers increases every year giving us opportunity to increase the quality and visibility of JIOS.I would like to use this opportunity to encourage prospective authors among you, dear readers, to submit papers at http://jios.foi.hr. You are also invited to share with us your comments or critical remarks regarding the papers previously published in the

  18. From the Editor

    Directory of Open Access Journals (Sweden)

    Neven Vrček

    2011-06-01

    Full Text Available Dear authors, readers and future authors,It is my pleasure to present you the 1st number of the 35th volume of the Journal of Information and Organizational Sciences – JIOS.In this issue a selection of 6 original scientific papers, 2 preliminary communications and 2 survey papers have been included, all of which have undergone a rigorous double-blind review process.Some of the papers published here were already presented at the CECIIS 2010 Conference held in Varaždin between 22nd and 24th September 2010. These papers were nominated for publishing in JIOS by the chairs of the conference tracks they were presented at on the account of their research quality.As in prior issues of the Journal, this one also comprises papers that cover themes from various ICT fields: databases, programming, IT supported learning, and other topics in the field of applied information sciences. We hope that the variety of themes will draw the attention of researchers in different ICT fields and motivate potential authors to expand the Journal’s thematic scope by other themes that may be of interest to the wider ICT research community.I would like to use this opportunity to encourage prospective authors among you, dear readers, to submit papers at jios.foi.hr. You are also invited to share with us your comments or critical remarks regarding the papers previously published in the Journal. Further, we would appreciate your willingness to become a peer-reviewed for submitted papers and thus contribute significantly to the rising quality of JIOS.So far JIOS has been indexed in seven well known databases and now this number has risen to nine, adding “SCOPUS” and “Library, Information Science & Technology Abstracts” to the database list. We are continuously investing a lot of effort to extend the list of databases where JIOS would be cited, in order to make the published papers available to a larger readers’ audience, and give your research a greater impact

  19. SOBRE EL LLENGUATGE CINEMATOGRÀFIC DE WERNER SCHROETER A MALINA, A PARTIR DE LA NOVEL·LA D’INGEBORG BACHMANN, AMB GUIÓ D’ELFRIEDE JELINEK

    Directory of Open Access Journals (Sweden)

    M. Loreto Vilar

    2015-12-01

    Full Text Available This paper provides an approach to the cinematic language in the film Malina (1991, directed by Werner Schroeter after Ingeborg Bachmann’s homonymous novel, script by Elfriede Jelinek. Working on the study by Ute Seiderer (1994 and the information provided by film editor Juliane Lorenz, the exposition and analysis of the mise-en-scène focuses on the following items: the temporal sequencing, the insinuatio in the film, the interaction between physical and psychological space, the music and the visual narrative of the end of the woman. Explored are also the motifs of ubiquitous fire, the crack in the wall and the game of mirrors. Together with the representation of the Malina character, they materialize the duality in the psyche of the woman writer in the main role and her struggle for existence.

  20. From the Editors

    Science.gov (United States)

    Pashinin, Pavel P.; Yermachenko, Valery M.; Yevseyev, Igor V.

    2010-01-01

    Dear readers and authors, This preface opens the seventh volume of the journal Laser Physics Letters. We are happy to inform you that the first six years have been quite successful for the journal. In the years 2004-2009, Laser Physics Letters published around 700 original articles written by scientists from 55 countries. During these years, in addition to original articles, Laser Physics Letters published about 40 brief review invited articles written by top scientists from different countries. These review articles provide readers a unique possibility of being timely informed on the current research in different fields of laser physics and on the most fresh and important results in these fields. The brief review articles, published in Laser Physics Letters, have attracted high attention of readers and are extensively cited. Some of these review articles have been cited more than 60 times in the main journals covered by ISI Web of Science. This shows the great importance and attractiveness of the published brief review invited articles for the laser physics community. We certainly understand that such a success is due to the following reasons. First of all, the authors of Laser Physics Letters are the top scientists in the field of laser physics from all over the world. And, second, all 28 members of the Editorial Board, representing 13 countries, are strongly committed to do all their best for making the journal an excellent forum for the laser physics community. Laser Physics Letters publishes pioneering articles in different fields of laser physics. In order to be accessible to a wide auditorium, the papers should clearly point out the main contributions of the article to the field of research and their relation to other articles treating the topic. A well-written introduction is a prerequisite for a good paper. This allows the readers to better judge on the contribution of the article and to objectively evaluate the presented results. We are proud to announce

  1. From the Editor

    Directory of Open Access Journals (Sweden)

    Neven Vrček

    2013-12-01

    Full Text Available Dear authors, readers and future authors,it is my pleasure to present you the 2nd number of the 37th volume of the Journal of Information and Organizational Sciences – JIOS.In this issue a selection of 3 original scientic papers and 2 preliminary communications has been included,  all  of  which  have  undergone  a  rigorous  double-blind  review  process  in  some  cases  in several rounds.The mission of JIOS is to cover scientic publications from broad area of information sciences and related  disciplines  and  we  continuously  receive  many  articles  in  which  authors  strive  to  achieve scientic  merit.  Our  review  procedure  is  very  strict  but  even  when  we  decline  papers  we  try  to encourage  authors  in  their  future  work  and  motivate  them  to  give  better  results. That  is  why  we maintain very good relations with our authors and we invite all of you to extend cooperation with JIOS.We  hope  that  the  variety  of  themes  will  draw  the  attention  of  researchers  in  di€erent  elds  of information sciences and motivate potential authors to expand the Journal’s thematic scope by other themes that may be of interest to the wider ICT research community. These themes motivate us to continue  our  work  of delivering  research  results  to  interested  audience. The  ICT  eld  is  changing rapidly and we are constantly searching for cutting edge articles that open perspective and motivate further research. We have to notice that future of ICT related research is in interdisciplinary approach and relations with other research domains which is highly emphasized in Horizon 2020 directions. That is why we encourage and promote scientic collaboration across scientic areas that will bring us new interesting articles. We hope that many of you who will read the Journal will join us as authors, readers and reviewers

  2. Eclipse Editor for MARC Records

    Directory of Open Access Journals (Sweden)

    Bojana Dimić Surla

    2012-09-01

    Full Text Available Editing bibliographic data is an important part of library information systems. In this paper we discuss existing approaches in developing of user interface for editing MARC records. There are two basic approaches, screen forms that support entering bibliographic data without knowledge of the MARC structure and direct editing of MARC records that is shown on the screen. The main result presented in the paper is Eclipse editor for MARC records that fully supports editing of MARC records. It is written in Java as Eclipse plug-in so it is platform-independent. It can be extended for using with any data store. At the end, the paper presents Rich Client Platform application made of MARC editor plug-in which can be used outside of Eclipse. The practical application of the results is integration of created Rich Client Platform application in BISIS library information system.

  3. EDITORIAL: Message from the Editor Message from the Editor

    Science.gov (United States)

    Thomas, Paul

    2010-02-01

    November 2009 and provided particularly detailed advice to the authors. The other three have been very helpful in 'minority fields'. We have excluded our Board members, Guest Editors of special editions and those referees who were already listed in the last four years. Guest Editors' work on papers submitted to their Special Issues is also excluded from consideration. The following people have been selected: Tomonori Takizuka, JAEA-Naka Fusion Institute, Japan Rudolf Neu, Max-Planck-Institut für Plasmaphysik, Germany Sibylle Guenter, Max-Planck-Institut für Plasmaphysik, Germany Taik-Soo Hahm, Princeton Plasma Physics Laboratory, United States David R. Mikkelsen, Princeton Plasma Physics Laboratory, United States Peter C. de Vries, EURATOM/UKAEA Fusion Association, United Kingdom Yasuhiro Suzuki, National Institute for Fusion Science, Japan Jerzy Wolowski, Institute of Plasma Physics and Laser Microfusion, Poland Tetsuo Tanabe, Kyushu University, Japan Yasuyuki Yagi, National Institute of Advanced Industrial Science and Technology, Japan Congratulations and many, many thanks! The Guest Editors of special editions deserve a special mention for the excellent help that they have given us. They are: Taik-Soo Hahm, Princeton Plasma Physics Laboratory, United States, Special Issue on H-Mode Physics and Transport Barriers Yaroslav Kolesnichenko, Institute for Nuclear Research, Ukraine, Special Issue on Energetic Particles in Magnetic Confinement Systems Kimitaka Itoh, National Institute for Fusion Science, Japan and Howard R. Wilson, University of York, UK, Special Issue on Plasma Instabilities Bernhard Unterberg, Forschungszentrum Juelich, Germany, Special Issue on Stochastic Fusion Plasma In addition, there is a group of several hundred referees who have helped us in the past year to maintain the high scientific standard of Nuclear Fusion. At the end of this issue we give the full list of all referees for 2009. Our thanks to them! Authors The winner of the 2009 Nuclear Fusion

  4. On the Work of the German-American Artist Werner Klotz

    DEFF Research Database (Denmark)

    Kacunko, Slavko

    2010-01-01

    A closer look is a must if we want to begin to appreciate the reflecting material and reflexive effect of German-American artist Werner Klotz’s array of Wahrnehmungsinstrumenten – his Instruments of Perception from today’s standpoint, better still one taken a step aside from the exploding Art...... as it was interesting then, to observe how in Werner Klotz’s oeuvre, following an artistic logic, they entered into a symbiosis with the closed-circuit video installations but have ultimately left that stage to today’s world-wide Public Art. Especially in his current public installations and projects, Werner Klotz...

  5. Quantum Errors and Disturbances: Response to Busch, Lahti and Werner

    Directory of Open Access Journals (Sweden)

    David Marcus Appleby

    2016-05-01

    Full Text Available Busch, Lahti and Werner (BLW have recently criticized the operator approach to the description of quantum errors and disturbances. Their criticisms are justified to the extent that the physical meaning of the operator definitions has not hitherto been adequately explained. We rectify that omission. We then examine BLW’s criticisms in the light of our analysis. We argue that, although the BLW approach favour (based on the Wasserstein two-deviation has its uses, there are important physical situations where an operator approach is preferable. We also discuss the reason why the error-disturbance relation is still giving rise to controversies almost a century after Heisenberg first stated his microscope argument. We argue that the source of the difficulties is the problem of interpretation, which is not so wholly disconnected from experimental practicalities as is sometimes supposed.

  6. Quantum Errors and Disturbances: Response to Busch, Lahti and Werner

    Science.gov (United States)

    Appleby, David

    2016-05-01

    Busch, Lahti and Werner (BLW) have recently criticized the operator approach to the description of quantum errors and disturbances. Their criticisms are justified to the extent that the physical meaning of the operator definitions has not hitherto been adequately explained. We rectify that omission. We then examine BLW's criticisms in the light of our analysis. We argue that, although the approach BLW favour (based on the Wasserstein 2-deviation) has its uses, there are important physical situations where an operator approach is preferable. We also discuss the reason why the error-disturbance relation is still giving rise to controversies almost a century after Heisenberg first stated his microscope argument. We argue that the source of the difficulties is the problem of interpretation, which is not so wholly disconnected from experimental practicalities as is sometimes supposed.

  7. Editoral

    Directory of Open Access Journals (Sweden)

    2009-07-01

    Full Text Available EDITORIALPoblación y Salud en Mesoamérica se complace en entregar a nuestros lectores y público en general el Volumen 7, número 1, correspondiente a julio-diciembre del 2009. En esta oportunidad se disponen 8 artículos divididos en 5 nuevos artículos científicos y 3 artículos en cada una de las secciones de Revisión bibliográfica, Ensayo y de Documentos históricos.La edición recoge dos trabajos elaborados a partir de los datos de la primera Encuesta Nacional de Salud de Costa Rica (ENSA 2006. En el primero, Morera y otros estudian los determinantes de la salud autopercibida en un análisis comparativo entre regiones geográficas, en el que después de controlar por una serie de variables sociodemográficas y socioeconómicas, les permite concluir que existen diferencias significativas a nivel regional para fundamentar una estrategia diferenciada de salud pública. En el segundo, Herring y Bonilla trabajan una submuestra de la ENSA con cerca de 200 inmigrantes de origen nicaragüense, y comparando con el resto de la población costarricense encuestada, utilizando distintos indicadores de salud autopercibida, llegan a concluir que el estado general de salud de los inmigrantes es igual y hasta mejor que la de los locales, producto de una selectividad de la migración, aunque los primeros acusan mayores conductas de riesgo como el fumado y sedentarismo en la actualidad, pero que evidencia que los nicaragüenses no están siendo una sobrecarga en cuanto al uso de los servicios de salud pública en Costa Rica.También a nivel regional pero con diferentes fuentes de información, el artículo de Santamaría aborda el tema de la incidencia del cáncer de mama, entre la población de las áreas de influencia de o exposición al uso de plaguicidas, en un interesante estudio de carácter también ecológico que al combinar análisis estadísticos y espaciales, encuentra una asociación directa y significativa entre la exposición a plaguicidas y los casos de cáncer de mama en mujeres mayores de 45 años residentes en las áreas rurales de los distritos de mayor exposición.Otro artículo ligado al ámbito de la salud reproductiva de la región es el de Remez y otros, quienes analizan datos de las Encuestas de Demografía y Salud (DHS por sus siglas en ingles, para comparar los cambios en la fecundidad adolescente entre los países centroamericanos de menor nivel socioeconómico (Guatemala, Honduras, Nicaragua y El Salvador. Comparando los comportamientos en la nupcialidad y fecundidad de dos cohortes de mujeres separadas por 20 años, encuentran que las uniones consensuales a edades tempranas han disminuido, sin embargo la incidencia en los primeros nacimientos a edad adolescente no muestras claros signos de disminución (excepto en Nicaragua, sobre todo por el efecto de factores como la baja escolaridad y la pobreza, a lo que sugieren reforzar y focalizar las estrategias para ayudar a las jóvenes a utilizar más los anticonceptivos antes y no después del primer nacimiento.El último artículo científico de este número (Cañedo, difiere de los temas anteriores pues aborda el fenómeno de la calidad del empleo entre los profesionales salidos de la Universidad Autónoma de Guerrero, Méjico, mediante un riguroso análisis de ecuaciones estructurales, para así poner a prueba supuestos de las teorías de capital humano, mercados segmentados y capital cultural, y concluye entre otras cosas que dicha calidad en aspectos no formales del capital humano como la experiencia laboral y el desempeño personal, junto al capital cultural familiar, se vuelven más significativos y relevantes que los aspectos formales del capital humano medidos por la formación académica obtenida.En las secciones de Revisión bibliográfica y Ensayo, se presentan dos artículos que abordan un tema de suma actualidad y pertinencia a futuro, como lo es el tema de los modelos de salud pública que tanto los nuevos paradigmas como las condiciones socio históricas actuales, perfilan para el siglo XXI. Por una parte, Chamizo reali

  8. Editoral

    OpenAIRE

    Editorial, Comité

    2010-01-01

    La Revista estudiantil de investigaciones históricas GOLIARDOS, ha tenido —muy a pesar nuestro— un desarrollo interrumpido en los últimos años, debido a que hemos tratado de llenar un vacío que nos había sido legado; sin embargo, se ha trabajado por devolver a la revista la seriedad necesaria para emprender un nuevo camino en el que cada vez más personas de la comunidad académica puedan ser partícipes. La presente edición ha sido a la vez un proceso de aprendizaje y el inicio de nuevos proyec...

  9. Nucleolin inhibits G4 oligonucleotide unwinding by Werner helicase.

    Directory of Open Access Journals (Sweden)

    Fred E Indig

    Full Text Available BACKGROUND: The Werner protein (WRNp, a member of the RecQ helicase family, is strongly associated with the nucleolus, as is nucleolin (NCL, an important nucleolar constituent protein. Both WRNp and NCL respond to the effects of DNA damaging agents. Therefore, we have investigated if these nuclear proteins interact and if this interaction has a possible functional significance in DNA damage repair. METHODOLOGY/PRINCIPAL FINDINGS: Here we report that WRNp interacts with the RNA-binding protein, NCL, based on immunoprecipitation, immunofluorescent co-localization in live and fixed cells, and direct binding of purified WRNp to nucleolin. We also map the binding region to the C-terminal domains of both proteins. Furthermore, treatment of U2OS cells with 15 µM of the Topoisomerase I inhibitor, camptothecin, causes the dissociation of the nucleolin-Werner complex in the nucleolus, followed by partial re-association in the nucleoplasm. Other DNA damaging agents, such as hydroxyurea, Mitomycin C, and aphidicolin do not have these effects. Nucleolin or its C-terminal fragment affected the helicase, but not the exonuclease activity of WRNp, by inhibiting WRN unwinding of G4 tetraplex DNA structures, as seen in activity assays and electrophoretic mobility shift assays (EMSA. CONCLUSIONS/SIGNIFICANCE: These data suggest that nucleolin may regulate G4 DNA unwinding by WRNp, possibly in response to certain DNA damaging agents. We postulate that the NCL-WRNp complex may contain an inactive form of WRNp, which is released from the nucleolus upon DNA damage. Then, when required, WRNp is released from inhibition and can participate in the DNA repair processes.

  10. Stochastic simulations of normal aging and Werner's syndrome.

    KAUST Repository

    Qi, Qi

    2014-04-26

    Human cells typically consist of 23 pairs of chromosomes. Telomeres are repetitive sequences of DNA located at the ends of chromosomes. During cell replication, a number of basepairs are lost from the end of the chromosome and this shortening restricts the number of divisions that a cell can complete before it becomes senescent, or non-replicative. In this paper, we use Monte Carlo simulations to form a stochastic model of telomere shortening to investigate how telomere shortening affects normal aging. Using this model, we study various hypotheses for the way in which shortening occurs by comparing their impact on aging at the chromosome and cell levels. We consider different types of length-dependent loss and replication probabilities to describe these processes. After analyzing a simple model for a population of independent chromosomes, we simulate a population of cells in which each cell has 46 chromosomes and the shortest telomere governs the replicative potential of the cell. We generalize these simulations to Werner\\'s syndrome, a condition in which large sections of DNA are removed during cell division and, amongst other conditions, results in rapid aging. Since the mechanisms governing the loss of additional basepairs are not known, we use our model to simulate a variety of possible forms for the rate at which additional telomeres are lost per replication and several expressions for how the probability of cell division depends on telomere length. As well as the evolution of the mean telomere length, we consider the standard deviation and the shape of the distribution. We compare our results with a variety of data from the literature, covering both experimental data and previous models. We find good agreement for the evolution of telomere length when plotted against population doubling.

  11. Quantum Discord and Entanglement of Quasi-Werner States Based on Bipartite Entangled Coherent States

    Science.gov (United States)

    Mishra, Manoj K.; Maurya, Ajay K.; Prakash, Hari

    2016-06-01

    Present work is an attempt to compare quantum discord and quantum entanglement of quasi-Werner states formed with the four bipartite entangled coherent states (ECS) used recently for quantum teleportation of a qubit encoded in superposed coherent state. Out of these, the quasi-Werner states based on maximally ECS due to its invariant nature under local operation is independent of measurement basis and mean photon numbers, while for quasi-Werner states based on non-maximally ECS, it depends upon measurement basis as well as on mean photon number. However, for large mean photon numbers since non-maximally ECS becomes almost maximally entangled therefore dependence of quantum discord for non-maximally ECS based quasi-Werner states on the measurement basis disappears.

  12. ON THE CONVERGENCE OF KING-WERNER ITERATIONMETHOD IN BANACH SPACE

    Institute of Scientific and Technical Information of China (English)

    Zheng-da Huang

    2000-01-01

    In this paper , a Kantorovitch-Ostrowskitype convergence theorem and an error estimate ofusing the information of higher derivativesat the center between initial points for King-Werner iteration method in Banachspace are established.

  13. Entanglement of Formation for Werner States and Isotropic States via Logical Gates

    Science.gov (United States)

    Bertini, Cesarino; Chiara, Maria Luisa Dalla; Leporini, Roberto

    To what extent is a logical characterization of entanglement possible? We investigate some correlations that hold between the concept of entanglement of formation for Werner states and for isotropic states and the probabilistic behavior of some quantum logical gates.

  14. Chondrosarcoma of the mandibular condyle in a patient with Werner syndrome: a case report.

    Science.gov (United States)

    Goutzanis, Labros; Kalfarentzos, Evagelos F; Petsinis, Vassilis; Papadogeorgakis, Nick

    2013-10-01

    Werner syndrome, also called progeria of the adult and pangeria is a rare autosomal recessive disorder that affects connective tissue throughout the body. It is associated with premature ageing and an increased risk of cancer and other diseases. The mean survival for patients with Werner syndrome is 47 years. Death usually occurs when patients are aged 30-65 years because of atherosclerosis or malignant tumours. The purpose of this paper is to present a patient with Werner syndrome exhibiting a chondrosarcoma of the left temporomandibular joint and ramus. To the best of our knowledge this is the first case, of a Werner syndrome patient with an associated head and neck chondrosarcoma being reported. The diagnostic procedure followed and management of the patient are outlined in the paper as well.

  15. EDITORIAL: Incoming Editor-in-Chief

    Science.gov (United States)

    Lidström, Suzanne

    2012-04-01

    semiconductors and certain complex materials. His recent interests have extended his domain of activity towards the field of quantum chemistry as he is now actively engaged in electronic structure theory and its applications, and light-matter interactions, in particular. The other new member of our editorial team, Professor David Keen, comes highly recommended by Professor Stephen Lovesey, a long-standing friend and former colleague, who was, himself, a former condensed matter editor for the journal many years ago. Professor Keen works in structural disorder, typically studying at the boundary between crystalline, amorphous and liquid phases using neutron and x-ray diffraction and atomistic modelling. Three examples of the areas in which he conducts research are 'liquid-like' disorder in superionic crystalline materials, solid-state amorphization transitions and disorder-induced properties, such as unusual negative thermal expansion. Through working at these boundaries, and at the ISIS neutron scattering facility at Rutherford Appleton Laboratory for over 20 years, he has gained wide experience of all areas of structural condensed matter physics, encompassing crystallography and the structure and simulation of liquid and amorphous materials. Professor Keen has been a Guest Editor for a number of special issues of Journal of Physics: Condensed Matter. My thanks are extended to Stephen for his advice and for recommending such an enthusiastic new editor to join us. Until recently, the extensive review process engaged by Physica Scripta involved almost every manuscript being forwarded to several researchers for examination. The volume of material being received at present, however, makes this procedure untenable and undesirable, as it would be unfair on those researchers willing to participate in the peer review process to continue to review articles that are obviously destined for rejection. Thus, as a direct result of the increase in volume, a screening procedure has been

  16. Donald R. Nielsen New WRR Editor

    Science.gov (United States)

    Robb, David W.

    Bridging the gap between the disciplines of engineering and agriculture is a major goal for Water Resources Research (WRR), says Donald R. Nielsen, who was appointed to a 4-year term as WRR editor, effective January 1, 1985. Nielsen succeeds Stephen J. Burges as the WRR editor for hydrology, physical, chemical, and biological sciences. Ronald G. Cummings, at the University of New Mexico, is the WRR editor for policy sciences, including economics, systems analysis, sociology, and law.

  17. Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome

    Directory of Open Access Journals (Sweden)

    Mark C. Bagley

    2010-06-01

    Full Text Available Werner syndrome provides a convincing model for aspects of the normal ageing phenotype and may provide a suitable model for therapeutic interventions designed to combat the ageing process. Cultured primary fibroblast cells from Werner syndrome patients provide a powerful model system to study the link between replicative senescence in vitro and in vivo pathophysiology. Genome instability, together with an increased pro-oxidant state, and frequent replication fork stalling, all provide plausible triggers for intracellular stress in Werner syndrome cells, and implicates p38 MAPK signaling in their shortened replicative lifespan. A number of different p38 MAPK inhibitor chemotypes have been prepared rapidly and efficiently using microwave heating techniques for biological study in Werner syndrome cells, including SB203580, VX-745, RO3201195, UR-13756 and BIRB 796, and their selectivity and potency evaluated in this cellular context. Werner syndrome fibroblasts treated with a p38 MAPK inhibitor reveal an unexpected reversal of the accelerated ageing phenotype. Thus the study of p38 inhibition and its effect upon Werner pathophysiology is likely to provide new revelations into the biological mechanisms operating in cellular senescence and human ageing in the future.

  18. Graphics editors in CPDev environment

    Directory of Open Access Journals (Sweden)

    Marcin Jamro

    2012-03-01

    Full Text Available According to IEC 61131-3 norm, controllers and distributed control systems can be programmed in textual and graphical languages. In many scenarios using a graphical language is preferred by the user, because diagrams can be more legible and easier to understand or modify also by people who do not have strong programming skills. What is more, they can be attached to the documentation to present a part of a system implementation. CPDev is an engineering environment that makes possible to program PLCs, PACs, softPLCs and distributed control systems with the usage of languages defined in IEC 61131-3 norm. In earlier versions, it supported only textual languages - ST and IL. Currently, graphics editors for FBD, LD and SFC languages are also available, so users can choose a suitable language depending on their skills and a specificity of a program that they have to prepare. The article presents implementation of the graphics editors, made by the author, which support creating program organization units in all graphical languages defined in IEC 61131-3 norm. They are equipped with a set of basic and complex functionalities to provide an easy and intuitive way of creating programs, function blocks and functions with visual programming. In the article the project structure and some important mechanisms are described. They include e.g. automatic connections finding (with A* algorithm, translation to ST code, conversion to and from XML format and an execution mode supporting multiple data sources and breakpoints.

  19. Learning the vi and Vim Editor

    CERN Document Server

    Robbins, Arnold; Hannah, Elbert

    2008-01-01

    There's nothing that hard-core Unix and Linux users are more fanatical about than their text editor. Editors are the subject of adoration and worship, or of scorn and ridicule, depending upon whether the topic of discussion is your editor or someone else's. vi has been the standard editor for close to 30 years. Popular on Unix and Linux, it has a growing following on Windows systems, too. Most experienced system administrators cite vi as their tool of choice. And since 1986, this book has been the guide for vi. However, Unix systems are not what they were 30 years ago, and neither is this

  20. EDITORIAL: Message from the Editor Message from the Editor

    Science.gov (United States)

    Thomas, Paul

    2011-01-01

    As usual, being an even year, the 23rd IAEA Fusion Energy Conference took place at Daejeon, Korea. The event was notable not just for the quality of the presentations but also for the spectacular opening ceremony, in the presence of the Prime Minister, Kim Hwang-sik. The Prime Minister affirmed the importance of research into fusion energy research and pledged support for ITER. Such political visibility is good news, of course, but it brings with it the obligation to perform. Fortunately, good performance was much in evidence in the papers presented at the conference, of which a significant proportion contain 'ITER' in the title. Given this importance of ITER and the undertaking by the Nuclear Fusion journal to publish papers associated with Fusion Energy Conference presentations, the Nuclear Fusion Editorial Board has decided to adopt a simplified journal scope that encompasses technology papers more naturally. The scope is available from http://iopscience.iop.org/0029-5515/page/Journal%20information but is reproduced here for clarity: Nuclear Fusion publishes articles making significant advances to the field of controlled thermonuclear fusion. The journal scope includes: the production, heating and confinement of high temperature plasmas; the physical properties of such plasmas; the experimental or theoretical methods of exploring or explaining them; fusion reactor physics; reactor concepts; fusion technologies. The key to scope acceptability is now '....significant advances....' rather than any particular area of controlled thermonuclear fusion research. It is hoped that this will make scope decisions easier for the Nuclear Fusion office, the referees and the Editor.The Nuclear Fusion journal has continued to make an important contribution to the research programme and has maintained its position as the leading journal in the field. This is underlined by the fact that Nuclear Fusion has received an impact factor of 4.270, as listed in ISI's 2009 Science Citation

  1. Examining Editor-Author Ethics: Real-World Scenarios from Interviews with Three Journal Editors

    Science.gov (United States)

    Amare, Nicole; Manning, Alan

    2009-01-01

    Those who submit manuscripts to academic journals may benefit from a better understanding of how editors weigh ethics in their interactions with authors. In an attempt to ascertain and to understand editors' ethics, we interviewed 3 current academic journal editors of technical and/or business communication journals. We asked them about the…

  2. Examining Editor-Author Ethics: Real-World Scenarios from Interviews with Three Journal Editors

    Science.gov (United States)

    Amare, Nicole; Manning, Alan

    2009-01-01

    Those who submit manuscripts to academic journals may benefit from a better understanding of how editors weigh ethics in their interactions with authors. In an attempt to ascertain and to understand editors' ethics, we interviewed 3 current academic journal editors of technical and/or business communication journals. We asked them about the…

  3. Handwritten Document Editor: An Approach

    Directory of Open Access Journals (Sweden)

    Sumit Nalawade

    2015-11-01

    Full Text Available With advancement in new technologies many individuals are moving towards personalization of the same. The same idea inspired us to develop a system which can provide a personal touch to all our documents including both electronic and paper media. In this article we are proposing a novel idea for creating an editor system which will take handwritten scanned document as the input, recognizes the characters from the document, then proceed with creating the font of recognized handwriting to allow user to edit the document. We have proposed use of genetic algorithm along with K-NN classifier for fast recognition of handwritten characters and use of marching squares algorithm for tracing contour points of characters to generate a handwritten font.

  4. Editorial - Letter from the Editors

    Directory of Open Access Journals (Sweden)

    Wilhelm Heitmeyer

    2008-11-01

    Full Text Available We are pleased to announce a number of additions to the Journal’s Advisory Board. We warmly welcome Julia Eckert (Max Planck Institute for Social Anthropology, Halle/Saale, Barbara Krahé (University of Potsdam, Gary LaFree (University of Maryland, and Loïc Wacquant (University of California, Berkeley. We are sure their expertise will provide valuable inputs for the journal’s future work and interdisciplinary approach.This time—as advertised in the spring issue—the focus section is on the topic of anomie/anomia. We would like to thank the guest editors, Steven F. Messner (University of Albany, New York and Helmut Thome (Martin Luther University, Halle-Wittenberg for the very fruitful and productive collaboration, and the impressive collection of papers they have put together.

  5. PROGRAMMABLE DISPLAY PUSHBUTTON LEGEND EDITOR

    Science.gov (United States)

    Busquets, A. M.

    1994-01-01

    The Programmable Display Pushbutton (PDP) is a pushbutton device available from Micro Switch which has a programmable 16 x 35 matrix of LEDs on the pushbutton surface. Any desired legends can be displayed on the PDPs, producing user-friendly applications which greatly reduce the need for dedicated manual controls. Because the PDP can interact with the operator, it can call for the correct response before transmitting its next message. It is both a simple manual control and a sophisticated programmable link between the operator and the host system. The Programmable Display Pushbutton Legend Editor, PDPE, is used to create the LED displays for the pushbuttons. PDPE encodes PDP control commands and legend data into message byte strings sent to a Logic Refresh and Control Unit (LRCU). The LRCU serves as the driver for a set of four PDPs. The legend editor (PDPE) transmits to the LRCU user specified commands that control what is displayed on the LED face of the individual pushbuttons. Upon receiving a command, the LRCU transmits an acknowledgement that the message was received and executed successfully. The user then observes the effect of the command on the PDP displays and decides whether or not to send the byte code of the message to a data file so that it may be called by an applications program. The PDPE program is written in FORTRAN for interactive execution. It was developed on a DEC VAX 11/780 under VMS. It has a central memory requirement of approximately 12800 bytes. It requires four Micro Switch PDPs and two RS-232 VAX 11/780 terminal ports. The PDPE program was developed in 1985.

  6. Editorial Commentary: Editor's Conflict of Interest.

    Science.gov (United States)

    Lubowitz, James H

    2015-09-01

    The Editor-in-chief has recused himself from industry consulting, which he performed before assuming the position, and returned related royalties and divested related stock options, in order to mitigate against conflict-of-interest. The Editor discloses affiliation with an institution that receives support from diverse industry partners in support of research and education.

  7. A Synonym for Editor Must Be Leader.

    Science.gov (United States)

    Konkle, Bruce E.

    2003-01-01

    Contends that in scholastic journalism, the editor might not be the best writer, designer, or photographer, but he or she must have a vision of what the final publication should be. Lists the following desirable traits of an editor: strong work ethic; motivation; organization; background knowledge; and responsibility. (PM)

  8. [The birth of acknowledgement: Michel Foucault and Werner Leibbrand].

    Science.gov (United States)

    Mildenberger, Florian

    2006-01-01

    In 1964, Werner Leibbrand (1896-1974) was the first German medical historian to present, in Sudhoffs Archiv, a review of the work of Michel Foucault (1926-1984). This paper examines some of the reasons leading to the fact that Leibbrand's own generation refused to acknowledge the importance of Foucault's ideas, while, later on, younger German medical historians, although impressed with Foucault's writings, failed to acknowledge, first, the close relationship between Leibbrand's and Foucault's world views, and, second, Leibbrand's attempts at introducing Foucault to German medical historians. Leibbrand with his Jewish wife had survived the Nazi period partly in hiding. His attempts at clearing post-war German psychiatry and medical historiography of NS-sympathizers isolated him among his colleagues, many of whom had begun their career during the Third Reich. Leibbrand enjoyed the support by the Swiss medical historian and avowed Communist Erwin Ackerknecht (1906-1988), but later turned against him, possibly because Acknerknecht had called Leibbrand's writings "unscientific". Leibbrand was unable to overcome his antagonisms with his contemporaries. At the same time, opposition to Ackerknecht made him appear a respresentative of the past in the eyes of the younger generation. Thus, when Foucault was accepted by the latter, they were not prepared to examine the work of Leibbrand and realize how close some of the ideas developed by Leibbrand and Foucault had been.

  9. Leg ulcer in Werner syndrome (adult progeria): a case report.

    Science.gov (United States)

    Fumo, Giuseppe; Pau, Monica; Patta, Federico; Aste, Nicola; Atzori, Laura

    2013-03-15

    Werner syndrome (WS; MIM#277700) or adult progeria, is a rare disease, associated with mutations of a single gene (RECQL2 or WRN), located on chromosome 8 (8p12). It codes a DNA-helicase, whose defects cause genomic instability. The highest incidences are reported in Japan and Sardinia (Italy). On this major island of the Mediterranean Basin, the WS cases have been observed in the northern areas. The authors describe the apparently first case reported in southern Sardinia, a 51-year-old woman, who was born in and resides in the province of Cagliari. She presented with a 9-year history of an intractable leg ulcer and other characteristic symptoms, including "bird-like" face, high-pitched voice, premature greying, short stature, abdominal obesity in contrast with thin body type, scleroderma-like legs, decreased muscle mass, diabetes, atherosclerosis, and premature menopause. A specialized genetic Institute of Research (IRCCS-IDI, Rome) confirmed the clinical diagnosis. There is no cure or specific treatment and patients must be periodically screened for an increased risk of cardiovascular and cerebrovascular disease and malignancies. Among the many findings, leg ulcers significantly affect the patient's quality of life. This problem may send the patient to the dermatologist, who finally suspects the diagnosis. Poor response to medical treatment may require aggressive repeated surgery, with poor or temporary results.

  10. Werner Hacke:卒中治疗的先驱

    Institute of Scientific and Technical Information of China (English)

    Geoff Watts; 李兆伟(译)

    2009-01-01

    作为其所在学科的权威,Werner Hacke早年的经历可谓一波三折。尽管他后来成为了德国海德堡大学神经病学系的主任,但通往这一职位的道路并非一帆风顺,一开始就困难重重。作为一名学习不太刻苦的高中生,Hacke曾决定学习医科,希望在将来能够将行医与他唯一擅长的学科——运动——结合起来。但他的成绩不够上医学院校,因此眼完兵役后,他开始主修心理学学位。他非常喜欢这门学科,

  11. Lyman-Werner UV escape fractions from primordial haloes

    Science.gov (United States)

    Schauer, Anna T. P.; Whalen, Daniel J.; Glover, Simon C. O.; Klessen, Ralf S.

    2015-12-01

    Population III (Pop III) stars can regulate star formation in the primordial Universe in several ways. They can ionize nearby haloes, and even if their ionizing photons are trapped by their own haloes, their Lyman-Werner (LW) photons can still escape and destroy H2 in other haloes, preventing them from cooling and forming stars. LW escape fractions are thus a key parameter in cosmological simulations of early reionization and star formation but have not yet been parametrized for realistic haloes by halo or stellar mass. To do so, we perform radiation hydrodynamical simulations of LW UV escape from 9-120 M⊙ Pop III stars in 105-107 M⊙ haloes with ZEUS-MP. We find that photons in the LW lines (i.e. those responsible for destroying H2 in nearby systems) have escape fractions ranging from 0 to 85 per cent. No LW photons escape the most massive halo in our sample, even from the most massive star. Escape fractions for photons elsewhere in the 11.18-13.6 eV energy range, which can be redshifted into the LW lines at cosmological distances, are generally much higher, being above 60 per cent for all but the least massive stars in the most massive haloes. We find that shielding of H2 by neutral hydrogen, which has been neglected in most studies to date, produces escape fractions that are up to a factor of 3 smaller than those predicted by H2 self-shielding alone.

  12. Lyman-Werner UV Escape Fractions from Primordial Halos

    CERN Document Server

    Schauer, Anna T P; Glover, Simon C O; Klessen, Ralf S

    2015-01-01

    Population III stars can regulate star formation in the primordial Universe in several ways. They can ionize nearby halos, and even if their ionizing photons are trapped by their own halos, their Lyman-Werner (LW) photons can still escape and destroy H$_2$ in other halos, preventing them from cooling and forming stars. LW escape fractions are thus a key parameter in cosmological simulations of early reionization and star formation but have not yet been parametrized for realistic halos by halo or stellar mass. To do so, we perform radiation hydrodynamical simulations of LW UV escape from 9--120 M$_{\\odot}$ Pop III stars in $10^5$ to $10^7$ M$_{\\odot}$ halos with ZEUS-MP. We find that photons in the LW lines (i.e. those responsible for destroying H$_{2}$ in nearby systems) have escape fractions ranging from 0% to 85%. No LW photons escape the most massive halo in our sample, even from the most massive star. Escape fractions for photons elsewhere in the 11.18--13.6~eV energy range, which can be redshifted into t...

  13. Editors' message--Hydrogeology Journal in 2003

    Science.gov (United States)

    Voss, Clifford; Olcott, Perry; Schneider, Robert

    2004-01-01

    Hydrogeology Journal appeared in six issues containing a total of 710 pages and 48 major articles, including 31 Papers and 14 Reports, as well as some Technical Notes and Book Reviews. The number of submitted manuscripts continues to increase. The final issue of 2003 also contained the annual volume index. Hydrogeology Journal (HJ) is an international forum for hydrogeology and related disciplines and authors in 2003 were from about 28 countries. Articles advanced hydrogeologic science and described hydrogeologic systems in many regions worldwide. These articles focused on a variety of general topics and on studies of hydrogeology in 24 countries: Afghanistan, Algeria, Argentina, Australia, Bangladesh, Belgium, Canada, Chile, China, Denmark, France, India, Italy, Mexico, Netherlands, New Zealand, Nigeria, Norway, Portugal, Russia, South Africa, Switzerland, Turkey, and U.S.A. The Guest Editor of the 2003 HJ theme issue on “Hydromechanics in Geology and Geotechnics”, Ove Stephansson, assembled a valuable collection of technical reviews and research papers from eminent authors on important aspects of the subject area.

  14. From editor-in-chief

    Directory of Open Access Journals (Sweden)

    Fokin V.F.

    2013-09-01

    Full Text Available Editor-in-chief (C. 3 Dear readers and authors of the journal "Asymmetry"! Summer and beginning of autumn is traditionally not only the time for vacations, but also a variety of conferences. I participated in the 21st world Congress of neurology held in late September in Vienna. In his many papers were devoted to various, for the most part, practically important issues neurology. While the theoretical aspects of neurology, one way or another, was also highlighted at the Congress, including the issues of asymmetry. I would like to highlight two areas. First of all, pay attention to enchanting lecture Nobel laureate E. Candela "Vienna and the age of insight", in which E. Kandel told about the influence of art Nouveau on the work of Z. Freud in psychoanalysis. (More about this can be found in the Facebook log "Asymmetry" - https://www.facebook.com/jasymmetry. In other words, it was about the translation of non-verbal images in some logical designs and ideas. Unfortunately, these research tasks are still in the field of theoretical developments. Another direction was reflected in the plenary lecture M Chilca "Stroke and autonomic nervous system. The lecture was directly associated survival after stroke in the basin of the carotid arteries with damage to the cortical representation of the autonomic nervous system, which, as you wrote about it, including, and in our magazine, also asymmetrically. When left hemispheric stroke the medial prefrontal cortex and the insulin are observed less pronounced change in the characteristics of the cardiovascular system, compared to the same right hemispheric strokes. This lecture aroused great interest. Thus, we see the development of the research two types of asymmetries, which in some cases are conducted in parallel: cognitive and autonomic asymmetry. "Vegetative" asymmetry is much less studied, although its contribution to the clinic, sports medicine and pedagogy can be very serious. I wish the readers of the

  15. From the Editor-in-Chief

    Directory of Open Access Journals (Sweden)

    Simeon Oka

    2010-01-01

    Full Text Available Dear readers of the journal Thermal Science This year we have for the first time a Supplement issue. There are many reasons for introducing Supplement issues besides the four regular issues in the Volume each year. This will be editorial policy in the next years. This year we have great increase of the number of submitted papers, and at the same time very interesting proposals of distinguished researchers to dedicate whole issue to the some modern and interesting scientific topics. The only solution is to have, one or more, Supplement issues in the year. Supplement issue to the Vol. 14, 2010, has several important characteristics. Supplement issue 2010, is devoted to the 50th anniversary of the Faculty of Mechanical Engineering, University of Kragujevac, Serbia. In the issue are presented the most important scientific and engineering results achieved in last several years by the Department of energy and process engineering of the Faculty. Some of the papers selected for this issue present also the results achieved in joint research of researchers of this Department and researches from other Universities in Serbia. To distinguish 50th anniversary of some research and education institution is the best opportunity to fulfil one of the main tasks of the journal Thermal Science, proposed even at the very beginning of the foundation of this journal, namely, to promote the best scientific results achieved in Serbia, and later also in the South-East European countries. If for education of the qualified researcher is necessary 10-15 years, for scientific institution to become mature, and to give recognized scientific results it is necessary to pass two or three in house made generations of the researchers. For this process about 50 years is necessary, and this is the reason why we accepted proposal of the Dean Professor Dr. Miroslav Babić, to devote one issue of the journal Thermal Science to the part of the scientific results achieved by the researcher

  16. Critical Criminology: Guest Editors' Introduction

    Directory of Open Access Journals (Sweden)

    Asher Flynn

    2016-03-01

    Full Text Available This issue of the International Journal for Crime, Justice and Social Democracy stems from selected papers delivered at the 2013 and 2014 Critical Criminology conferences convened in, respectively, Adelaide (Flinders University and Melbourne (Monash University. This was the final occasion when the Critical Criminology event would be held in successive years. In future, this conference will alternate with the Crime, Justice and Social Democracy Conference (hosted biennially by the Queensland University of Technology. As guest editors and the conferences’ facilitators, we examined the abstracts across both events and listened to as many speakers as possible with the view to inviting submissions from a mix of Australian and international delegates, including a selection of postgraduate and early career researchers.The papers published in this issue provide solid evidence of not only the liveliness of critical criminological thought, but also its relevance to the twenty-first century problems besetting various governments and communities around the world.To find out more about this special edition, download the PDF file from this page.

  17. Editorial: Letter from the Editors

    Directory of Open Access Journals (Sweden)

    Wilhelm Heitmeyer

    2012-05-01

    Full Text Available This time our focus section features work from the first conference hosted by IJCV. In 2011 Donatella della Porta and Gary LaFree, both members of the journal’s advisory board, brought together in Bielefeld experts from around the world to thoroughly debate the question of radicalization and de-radicalization. In contrast to prior approaches that mostly focused on the context of terrorism, the aim of this focus section is to present work employing new theoretical and methodological approaches to generate findings that go well beyond terrorism and related phenomena and thus contribute to a more comprehensive understanding of the processes, dynamics, and mechanisms of radicalization and de-radicalization. Our heartfelt thanks go to the two guest editors – as well as the entire conference team – for realising this ambitious project and for putting together this collection of papers.The open section contains two articles of additional interest. Rafi Nets-Zehngut uses the example of the 1948 Palestinian exodus to describe the characteristics of internal and external collective memories in Israeli society. The section closes with a contribution by Claudia Diehl and Jan-Philipp Steinmann who explore the impact of the release and public discussion of Thilo Sarrazin’s book Deutschland schafft sich ab (Germany abolishes itself on public perception of immigrants in Germany.

  18. Editorial: Letter from the Editors

    Directory of Open Access Journals (Sweden)

    Andreas Zick

    2015-07-01

    Full Text Available Editorial 8(2 We are pleased to present issue 8 (2. The focus section is edited by Helmut Thome (University of Halle-Wittenberg, Germany and Steven F. Messner (University at Albany, United States, and focuses on methodological constraints, options, and solutions in longitudinal research on criminal violence. We are honored that Helmut Thome, Steven Messner, and the contributors offer their scientific knowledge and evidence in the interests of gaining a deeper understanding of one of the most promising methodological approaches in conflict and violence research, i.e. longitudinal data analyses. Sincere thanks to the editors and authors for opening up the potential of this specific kind of research for advances to better assess and understand criminal violence in a long term perspective. We hope this issue will be discussed and quoted in the interdisciplinary community of researchers. The open section again fulfills its aim to foster contributions on diverse topics in the field of conflict and violence, starting with an analysis of Southeast Asian media reception of the Israeli/Palestine conflict. The second paper shows how social cohesion activities have the potential to change disparaging attitudes in Cyprus. The third and final contribution examines teen dating violence in Switzerland from various angles.

  19. New Classification of Herlyn-Werner-Wunderlich Syndrome

    Directory of Open Access Journals (Sweden)

    Lan Zhu

    2015-01-01

    Full Text Available Background: Uterus didelphys and blind hemivagina associated with ipsilateral renal agenesis are collectively known as Herlyn-Werner-Wunderlich syndrome (HWWS. In the literature, the syndrome often appears as a single case report or as a small series. In our study, we reviewed the characteristics of all HWWS patients at Peking Union Medical College Hospital (PUMCH and suggested a new classification for this syndrome because the clinical characteristics differed significantly between the completely and incompletely obstructed vaginal septum. This new classification allows for earlier diagnosis and treatment. Methods: From January 1986 to March 2013, all diagnosed cases of HWWS at PUMCH were reviewed. A retrospective long-term follow-up study of the clinical presentation, surgical prognosis, and pregnancy outcomes was performed. Statistical analyses were performed using SPSS, version 15.0 (IBM, Armonk, NY, USA. Between-group comparisons were performed using the χ2 test, Fisher′s exact test, and the t-test. The significance level for all analyses was set at P < 0.05. Results: The clinical data from 79 patients with HWWS were analyzed until March 31, 2013. According to our newly identified characteristics, we recommend that the syndrome be classified by the complete or incomplete obstruction of the hemivagina as follows: Classification 1, a completely obstructed hemivagina and Classification 2, an incompletely obstructed hemivagina. The clinical details associated with these two types are distinctly different. Conclusions: HWWS patients should be differentiated according to these two classifications. The two classifications could be generalized by gynecologists world-wide.

  20. Encuentro de editores científicos

    OpenAIRE

    Gálvez Calla, Luis H.; Director de la revista Odontología Sanmarquina.

    2014-01-01

    La Asociación Peruana de Editores Científicos (APECi), entidad dedicada a fomentar la publicación de artículos y revistas científicas con estándares internacionales, estuvo presente en nuestra casa superior de estudios a fines de noviembre del 2006 con motivo del Primer Encuentro Nacional de Editores de Revistas Científicas (ENERC 1) realizada con la finalidad de alcanzar los objetivos que persigue. La Asociación Peruana de Editores Científicos (APECi), entidad dedicada a fomentar la publi...

  1. Hydrogen sulfide restores a normal morphological phenotype in Werner syndrome fibroblasts, attenuates oxidative damage and modulates mTOR pathway

    NARCIS (Netherlands)

    Talaei, F.; van Praag, V. M.; Henning, R. H.

    2013-01-01

    Werner syndrome (WS) protein is involved in DNA repair and its truncation causes Werner syndrome, an autosomal recessive genetic disorder with a premature aging phenotype. WRN protein mutation is currently known as the primary cause of WS. In cultured WS fibroblasts, we found an increase in cytosoli

  2. Hydrogen sulfide restores a normal morphological phenotype in Werner syndrome fibroblasts, attenuates oxidative damage and modulates mTOR pathway

    NARCIS (Netherlands)

    Talaei, F.; van Praag, V. M.; Henning, R. H.

    2013-01-01

    Werner syndrome (WS) protein is involved in DNA repair and its truncation causes Werner syndrome, an autosomal recessive genetic disorder with a premature aging phenotype. WRN protein mutation is currently known as the primary cause of WS. In cultured WS fibroblasts, we found an increase in cytosoli

  3. Aortic valve replacement for aortic stenosis with a small aortic annulus in a patient having Werner's syndrome and liver cirrhosis.

    Science.gov (United States)

    Sogawa, M; Kasuya, S; Yamamoto, K; Koshika, M; Oguma, F; Hayashi, J

    2001-12-01

    Werner's syndrome is a rare genetic disease characterized by premature aging and scleroderma-like involvement of the skin. We report a case of aortic valve replacement for severely calcified aortic valve stenosis with a small annulus in a patient suffering from Werner's syndrome and liver cirrhosis

  4. Excitation of the Werner bands of H2 by electron impact.

    Science.gov (United States)

    Stone, E. J.; Zipf, E. C.

    1972-01-01

    Absolute cross sections for the excitation of the Werner band system of molecular hydrogen have been measured from energy threshold to 300 eV for electron impact on molecular hydrogen. The bands were observed in emission in the wavelength region of 1100 to 1250 A. From a comparison of the measured cross sections with previously calculated transition probabilities, it is concluded that the Werner bands are suitable as the basis for relative spectral response calibration only when the bands are observed under sufficiently high resolution. The effect of the perturbation interaction between the B and C states of the hydrogen molecule was observed in the rotational intensity distribution of the Werner (3,7) and (3,6) bands.

  5. Hypermutable ligation of plasmid DNA ends in cells from patients with Werner syndrome.

    Science.gov (United States)

    Rünger, T M; Bauer, C; Dekant, B; Möller, K; Sobotta, P; Czerny, C; Poot, M; Martin, G M

    1994-01-01

    Werner Syndrome is a rare autosomal recessive disorder characterized by an increased cancer risk and by symptoms suggestive of premature aging. Cells from these patients demonstrate a typical pattern of chromosomal instability and a spontaneous hypermutability with a high rate of unusually large deletions. We have studied the in vivo DNA ligation in three lymphoblast cell lines from Werner syndrome patients and three from normal donors. In our host cell ligation assay we transfected linearized plasmid pZ189 and measured the amount of plasmid DNA ends rejoined by these host cells as the ability of the recovered plasmid to transform bacteria. A mutagenesis marker gene close to the ligation site allowed screening for mutations. Subsequent mutation analysis provided information about the accuracy of the ligation process. The cells from Werner syndrome patients were as effective as normal cells in ligating DNA ends. However, mutation analysis revealed that the three Werner syndrome cell lines introduced 2.4-4.6 times more mutations (p < 0.001) than the normal cell lines during ligation of the DNA ends: the mutation rates were 69.4, 97.2, and 58.7%, as compared to 23.6, 21.7, and 24.4% in the normal cell lines. These increased mutation frequencies in plasmids ligated during passage through Werner syndrome cells were mainly due to a significant (p < 0.001) increase in deletions. This error-prone DNA ligation might be responsible for the spontaneous hypermutability and the genomic instability in Werner syndrome cells and related to the apparently accelerated aging and high cancer risk in affected patients.

  6. U.S. EPA Metadata Editor (EME)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The EPA Metadata Editor (EME) allows users to create geospatial metadata that meets EPA's requirements. The tool has been developed as a desktop application that...

  7. Sir William Wilde: an enlightened editor.

    Science.gov (United States)

    O'Doherty, M

    2016-05-01

    This paper examines Sir William Wilde's peculiar genius as editor, his contribution to the Irish Journal of Medical Science in ensuring its endurance and making it a treasure-house of the history of medicine in Ireland.

  8. Alfred Werner's role in the mid-20th century flourishing of American inorganic chemistry.

    Science.gov (United States)

    Labinger, Jay A

    2014-01-01

    The development of organic and physical chemistry as specialist fields, during the middle and end of the 19th century respectively, left inorganic behind as a decidedly less highly regarded subfield of chemistry. Despite Alfred Werner's groundbreaking studies of coordination chemistry in the early 20th century, that inferior status remained in place - particularly in the US - until the 1950s, when the beginnings of a resurgence that eventually restored its parity with the other subfields can be clearly observed. This paper explores the extent to which Werner's heritage - both direct, in the form of academic descendants, and indirect - contributed to those advances.

  9. Letter from Editors-in-Chief

    Institute of Scientific and Technical Information of China (English)

    Kwok-Fai So; Xiao-Ming Xu

    2011-01-01

    @@ Dear readers, We would first like to take this opportunity to wish you all a very happy, prosperous, and productive New Year! We are honored and enthusiastic to begin the year as the new Editors-In-Chief of Neural Regeneration Research (NRR). Through the leadership and scholarship of founding Editor-In-Chief, Professor Qunyuan Xu, NRR has become a successful and respected peer-reviewed intemational journal focusing exclusively on the exciting field of neural regeneration research.

  10. DeviceEditor visual biological CAD canvas

    Directory of Open Access Journals (Sweden)

    Chen Joanna

    2012-02-01

    Full Text Available Abstract Background Biological Computer Aided Design (bioCAD assists the de novo design and selection of existing genetic components to achieve a desired biological activity, as part of an integrated design-build-test cycle. To meet the emerging needs of Synthetic Biology, bioCAD tools must address the increasing prevalence of combinatorial library design, design rule specification, and scar-less multi-part DNA assembly. Results We report the development and deployment of web-based bioCAD software, DeviceEditor, which provides a graphical design environment that mimics the intuitive visual whiteboard design process practiced in biological laboratories. The key innovations of DeviceEditor include visual combinatorial library design, direct integration with scar-less multi-part DNA assembly design automation, and a graphical user interface for the creation and modification of design specification rules. We demonstrate how biological designs are rendered on the DeviceEditor canvas, and we present effective visualizations of genetic component ordering and combinatorial variations within complex designs. Conclusions DeviceEditor liberates researchers from DNA base-pair manipulation, and enables users to create successful prototypes using standardized, functional, and visual abstractions. Open and documented software interfaces support further integration of DeviceEditor with other bioCAD tools and software platforms. DeviceEditor saves researcher time and institutional resources through correct-by-construction design, the automation of tedious tasks, design reuse, and the minimization of DNA assembly costs.

  11. Concerned Journals, Editors And ICMJE

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2007-01-01

    Full Text Available This section will detail some important initiatives taken by journal editors in writing about industry influence on academia in particular and medicine in general. It will also look into the Revised Guidelines of the ICMJE vis-à-vis issues related to industry-sponsored research. Journals And Editors In the last chapter, we saw how conflict of interest related to individuals and institutions are discussed and resolved by AAMC. Conflict of interest because of industry's increasing clout has also engaged the attention of editors of important journals and some significant editorials in this connection are worth a close study by all concerned researchers and institutions, for they reflect reasoned responses to disturbing developments. The titles themselves reflect their concern:Is academic medicine for sale? (Angell, N Engl J Med , 2000Angell asks a piquant question of academic medical institutions:'Academic medical institutions are themselves growing increasingly beholden to industry. How can they justify rigorous conflict-of-interest policies for individual researchers when their own ties are so extensive?' Answering as to why Academia-industry connect flourishes, she says: 'Some academic institutions have entered into partnerships with drug companies to set up research centers and teaching programs in which students and faculty members essentially carry out industry research. Both sides see great benefit in this arrangement. For financially struggling medical centers, it means cash. For the companies that make the drugs and devices, it means access to research talent, as well as affiliation with a prestigious "brand." Asking herself the question: 'Why shouldn't clinical researchers have close ties to industry?' she answers it decisively tilts academia's inclinations to serve industry interests in various ways, rather than that of biomedical advance:'One obvious concern is that these ties will bias research, both the kind of work that is done and

  12. [Report of the editors, 2013].

    Science.gov (United States)

    García Puig, J; Gaspar Alonso-Vega, G; Ríos Blanco, J J

    2014-01-01

    The editors of Revista Clínica Española(Rev Clin Esp) inform on their editorial activity during the last 12 months: (a) objectives and attainments, (b) editorial activity, and (c) objectives for 2014. In 2013 the most relevant modification concerning the editorial activity has been the translation into English of the 5 manuscripts with abstract contained in each issue (http://www.revclinesp.es/). From the first January to the 30th September 2013 we received 458 manuscripts (50.9 manuscripts per month), a similar figure to that obtained in 2012 (51.1 manuscripts per month). The acceptance rate of the 443 manuscripts whose editorial process has been concluded was 23.7% (originals, 11.8%). We asked for 253 revisions to 186 reviewers and we received 74.4% revisions in less than 2 weeks (10.9 days). The mean time to adopt an editorial decision for all manuscripts («accepted»/«rejected») has been 20,3 (half than in 2009). For «originals» this figure has dropped from 56.6 days in 2009 to 22.5 days in 2013. The mean time elapsed from manuscript reception to its on-line publication was 94.8 days in 2013 (110.5 in 2012 and 155.8 in 2011). In 2013 the collaboration with the working groups from the Internal Medicine Spanish Foundation has reported 17 published manuscripts. In 2013 we were informed that the Journal Citation Reports excluded Rev Clin Esp from its impact factor journal list due to its elevated self-citations. We have taken a number of actions to reduce self-citations and we expect to be a minority in 2014. Some other data concerning the editorial policy are encouraging. In this sense, manuscript citation to Rev Clin Esp published articles has seen a substantial increase from 19% in 2008 to 29% in 2012. We work to achieve the digitalization of Rev Clin Esp from 1940 to 1999 (the journal is already digitalized since 2000). The continuous renewal of the journal sections and the working groups collaboration are necessary elements to make our journal, each day

  13. Report of the editors, 2014.

    Science.gov (United States)

    García Puig, J; Gaspar Alonso-Vega, G; Ríos Blanco, J J

    2015-01-01

    The editors of Revista Clínica Española(Rev Clin Esp) inform on their editorial activity during the last 12 months: (a) Objectives and attainments in 2014, (b) Editorial activity, 2014, and (c) 2013 impact factor. In 2014 we achieved the 5 planned objectives. We have published the 9 programmed issues and 103% of the planned papers according to the usual fixed sections. We emphasize the publication of 29 editorials, 21 of which are signed by prestigious foreign authors. From the first January to the 30th September 2014 we received 421 manuscripts (46.8 manuscripts per month), a slight lower figure to that obtained in 2013 (50.9 manuscripts per month). The acceptance rate of the 404 manuscripts whose editorial process has been concluded was 32.3% (originals, 22.4%). We asked for 315 revisions to 240 reviewers and we received 53.3% revisions in less than two weeks (10.4 days). The mean time to adopt an editorial decision for all manuscripts («accepted»/«rejected») has been 18,3 (less than half than in 2009). For «originals» this figure has dropped from 56,6 days in 2009 to 26.6 days in 2014. The mean time elapsed from manuscript reception to its on-line publication was 103 days. In 2014 the collaboration with the working groups from the Internal Medicine Spanish Foundation (FEMI) has reported 11 published manuscripts. In July 2014 we were informed that the Journal Citation Reports gave Rev Clin Esp an Impact Factor of 1,314 (year 2013). This Impact Factor without self-citations would have been 0.705 (in 2009 the global impact factor was 0,584). With the Editorial Committee farewell we welcome the new editorial team and we sincerely thank the SEMI Steering Committee, our colleagues, journal officers, reviewers, readers and authors that since 2009 have trusted on our editorial work. Copyright © 2014 Elsevier España, S.L.U. All rights reserved.

  14. From the Editors – Redactioneel

    Directory of Open Access Journals (Sweden)

    Catrien Santing

    2015-12-01

    , elected as the King ofthe Romans in 1247. The editors hope you will royally enjoy reading this new number.

  15. [The Chilean Association of Biomedical Journal Editors].

    Science.gov (United States)

    Reyes, H

    2001-01-01

    On September 29th, 2000, The Chilean Association of Biomedical Journal Editors was founded, sponsored by the "Comisión Nacional de Investigación Científica y Tecnológica (CONICYT)" (the Governmental Agency promoting and funding scientific research and technological development in Chile) and the "Sociedad Médica de Santiago" (Chilean Society of Internal Medicine). The Association adopted the goals of the World Association of Medical Editors (WAME) and therefore it will foster "cooperation and communication among Editors of Chilean biomedical journals; to improve editorial standards, to promote professionalism in medical editing through education, self-criticism and self-regulation; and to encourage research on the principles and practice of medical editing". Twenty nine journals covering a closely similar number of different biomedical sciences, medical specialties, veterinary, dentistry and nursing, became Founding Members of the Association. A Governing Board was elected: President: Humberto Reyes, M.D. (Editor, Revista Médica de Chile); Vice-President: Mariano del Sol, M.D. (Editor, Revista Chilena de Anatomía); Secretary: Anna María Prat (CONICYT); Councilors: Manuel Krauskopff, Ph.D. (Editor, Biological Research) and Maritza Rahal, M.D. (Editor, Revista de Otorrinolaringología y Cirugía de Cabeza y Cuello). The Association will organize a Symposium on Biomedical Journal Editing and will spread information stimulating Chilean biomedical journals to become indexed in international databases and in SciELO-Chile, the main Chilean scientific website (www.scielo.cl).

  16. Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes.

    Science.gov (United States)

    Du, Xiaobing; Shen, Johnny; Kugan, Nishan; Furth, Emma E; Lombard, David B; Cheung, Catherine; Pak, Sally; Luo, Guangbin; Pignolo, Robert J; DePinho, Ronald A; Guarente, Leonard; Johnson, F Brad

    2004-10-01

    The Werner and Bloom syndromes are caused by loss-of-function mutations in WRN and BLM, respectively, which encode the RecQ family DNA helicases WRN and BLM, respectively. Persons with Werner syndrome displays premature aging of the skin, vasculature, reproductive system, and bone, and those with Bloom syndrome display more limited features of aging, including premature menopause; both syndromes involve genome instability and increased cancer. The proteins participate in recombinational repair of stalled replication forks or DNA breaks, but the precise functions of the proteins that prevent rapid aging are unknown. Accumulating evidence points to telomeres as targets of WRN and BLM, but the importance in vivo of the proteins in telomere biology has not been tested. We show that Wrn and Blm mutations each accentuate pathology in later-generation mice lacking the telomerase RNA template Terc, including acceleration of phenotypes characteristic of latest-generation Terc mutants. Furthermore, pathology not observed in Terc mutants but similar to that observed in Werner syndrome and Bloom syndrome, such as bone loss, was observed. The pathology was accompanied by enhanced telomere dysfunction, including end-to-end chromosome fusions and greater loss of telomere repeat DNA compared with Terc mutants. These findings indicate that telomere dysfunction may contribute to the pathogenesis of Werner syndrome and Bloom syndrome.

  17. On the Work of the German-American Artist Werner Klotz

    DEFF Research Database (Denmark)

    Kacunko, Slavko

    2010-01-01

    A closer look is a must if we want to begin to appreciate the reflecting material and reflexive effect of German-American artist Werner Klotz’s array of Wahrnehmungsinstrumenten – his Instruments of Perception from today’s standpoint, better still one taken a step aside from the exploding Art...

  18. Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors

    DEFF Research Database (Denmark)

    Saydam, Nurten; Kanagaraj, Radhakrishnan; Dietschy, Tobias;

    2007-01-01

    Werner syndrome (WS) is a severe recessive disorder characterized by premature aging, cancer predisposition and genomic instability. The gene mutated in WS encodes a bi-functional enzyme called WRN that acts as a RecQ-type DNA helicase and a 3'-5' exonuclease, but its exact role in DNA metabolism...

  19. Werner Koch Maschinenfabrik:先进的模块化辅助加工技术

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Werner Koch Maschinenfabrik拥有33年的历史,是全球知名的专业化混料、定量给料、输送、干燥系统供应商,其产品以创新、高精确度、灵活和低成本而著称。

  20. Computer Series, 85. Werner and Jorgensen: Presenting History with a Computer.

    Science.gov (United States)

    Whisnant, David M.

    1987-01-01

    Describes a computer simulation which deals with the Werner-Jorgensen controversy from the standpoint of Kuhn's description of scientific change. Encourages the use of such instructional approaches to introduce general chemistry students to the process of science, including how (1) theories develop, (2) change occurs, and (3) scientists behave.…

  1. Werner-Type Matrix Valued Rational Interpolation and Its Recurrence Algorithms

    Institute of Scientific and Technical Information of China (English)

    顾传青; 王金波

    2004-01-01

    In this paper, a practical Werner-type continued fraction method for solving matrix valued rational interpolation problem isprovided by using a generalized inverse of matrices. In order to reduce the continued fraction form to rational function form of the in-terpolants, an efficient forward recurrence algorithm is obtained.

  2. 3. Chromosomal instability in B-lymphoblasotoid cell lines from Werner's and Bloom's syndrome patients

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@Werner's syndrome (WS) and Bloom's syndrome (BS) are rare autosomal recessive diseases in which the feature of premature aging and the elevated risk of neoplasia may be associated with genomic instability. To cha-racterize the genomic instability of WS and BS, B-lymphoblastoid cell lines (LCLs) from WS and BS patients were cytogenetically analyzed, comparing to those from healthy donors. Although all

  3. Generation of Werner-like stationary states of two qubits in a thermal reservoir

    CERN Document Server

    Jakobczyk, Lech

    2009-01-01

    The dynamics of entanglement between two-level atoms immersed in a common photon reservoir at finite temperature is investigated. It is shown that in the regime of strong correlations there are nontrivial asymptotic states which can be interpreted in terms of thermal generalization of Werner states.

  4. EDITORIAL: Letter from the Editor

    Science.gov (United States)

    Hauptmann, Peter

    2008-01-01

    Dear authors and reviewers of articles for Measurement Science and Technology, I would like to thank all those who have published papers with us in 2007, and special thanks go to those of you who have kindly reviewed articles for the journal this year. I would also like to take this opportunity to update you on some of the developments on the journal. As many of you are no doubt aware, our latest impact factor (a measure of the average number of times recent papers are referred to by others) has risen to 1.228. This is often taken as an indication of the quality and relevance of recently published research, and although as readers we develop our own instinct for journals of high quality, it is gratifying as an Editor to see the data from an independent organization agreeing with my own assessment. The popularity of the journal amongst authors and readers has prompted us to introduce a new subject classification for articles, to make it easier for readers to find articles of interest. The eight subject categories are: Measurement theory and practical developments (e.g. precision measurements, metrology, new measurement principles, signal processing techniques, theory of measurement, calibration); Sensors and sensing systems (based on physical, chemical or biological principles; micro- and nano-scale systems; sensors for physical, chemical and biological quantities); Optical and laser based techniques (e.g. fibre optics, interferometry, etc); Fluid mechanics measurements (e.g. fluid flow, velocimetry, particle sizing, etc); Imaging techniques (e.g. tomography, microscopy, holography, THz, etc); Spectroscopy (e.g. optical, acoustic, dielectric, MS, NMR, ESR, IR, UV-VIS, fluorescence, PCS, x-ray, etc); New and improved techniques for materials evaluation (e.g. non-destructive testing and evaluation, structural measurements); Novel instrumentation. We kindly ask you to assign your paper to a category when you send it to the journal. In order to maintain our rapid

  5. EDITORIAL: Letter from the Editor

    Science.gov (United States)

    Hauptmann, Peter

    2009-01-01

    Marella de Angelis and her colleagues on precision gravimetry using atomic sensors and from Dr Peter Becker on determination of the Avogadro constant via enriched silicon-28. I recommend setting up a free e-mail alert so that you can read them as soon as they are published! As many of you are already aware, our impact factor (a measure of the average number of times recent papers are referred to by others) has risen again to 1.297. This is often taken as an indication of the quality and relevance of recently published research, and although as readers we develop our own instinct for journals of high quality, it is gratifying as an Editor to see the data from an independent organization (Thomson ISI) agreeing with my own assessment. Of course the publication of high quality articles in the journal is dependent both on you the authors who trust us with the publication of your best work and on our referees and Editorial Board Members who we depend on to maintain the high standards you have grown to expect. I must also thank our referees for their rapid response when asked to review papers for Measurement Science and Technology. On average, authors receive a decision on their article in 45 days. Therefore I would like to end this message by saying thank you again to all those who have contributed to our success in the past year, and wish you all the best for a successful 2009!

  6. CERN Courier editors through 50 years

    CERN Multimedia

    2009-01-01

    The 50th anniversary of the first publication of the CERN Courier provided the opportunity for a modest celebration on 2 September 2009. All six of the principal editors that the magazine has had over its 50 years met together for the first time. After getting acquainted and re-acquainted over lunch, they gathered in the library at CERN to answer questions about producing the magazine over the years. From right to left, from the first editor to the present incumbent: Roger Anthoine, Alec Hester, Brian Southworth, Gordon Fraser, James Gillies and Christine Sutton.

  7. Help Wanted – JIBC Assistant Editors

    Directory of Open Access Journals (Sweden)

    Nahum Goldmann

    2011-04-01

    Full Text Available JIBC is growing, and as a part of new opportunities we are looking for two new key members of our editorial team to act as Assistant Editors . The candidates should be open to evolving responsibilities, have strong research, organizational and communication skills, ability to work both independently and with the JIBC editorial team, proficiency at multitasking, and be passionate about the newly emerging field of electronic banking and commerce. Past editors have used the position as a staging ground for the leading positions in the global academia and industry

  8. EDITORIAL: Letter from the Editor

    Science.gov (United States)

    Hauptmann, Peter

    2006-12-01

    Dear authors and reviewers of articles for Measurement Science and Technology, I would like to thank all those who have published papers with us in 2006, and special thanks go to those of you who have kindly reviewed articles for the journal this year. I would also like to take this opportunity to update you on some of the developments on the journal this year. As many of you are no doubt aware our impact factor (a measure of the average number of times recent papers are referred to by others) has remained above 1 for the second year in a row. This is often taken as an indication of the quality and relevance of recently published research, and although as readers we develop our own instinct for journals of high quality, it is gratifying as an Editor to see the data from an independent organization agreeing with my own assessment. This year we have welcomed several new faces to our Editorial Board and International Advisory Board. We are delighted to welcome Professor Hirofumi Yamada of the University of Kyoto as a representative from Japan. From China we have been joined by Professor Xuzong Chen of Peking University and Professor Zhiyi Wei of Chinese Academy of Sciences, Beijing. Professor Ivan Marusic from University of Minnesota and Dr Paul Williams of the National Institute of Standards and Technology in Boulder have joined as North American representatives. As usual you will be able to submit your articles through them or direct to the Editorial Office in Bristol, UK. As part of our ongoing initiative to give our authors' work the highest visibility, all articles are freely available online for 30 days from the date of publication, allowing all researchers to read and view the latest research as soon as it is published, and this year there have been many interesting articles to read! As regular readers are aware, Measurement Science and Technology publishes special issues and features, which highlight an area of current interest. This year's topics included

  9. A PAIDERASTIA SOB O HISTORICISMO DE WERNER JAEGER. (Dossiê: O Mundo Antigo: Literatura e Historiografia

    Directory of Open Access Journals (Sweden)

    Daniel Barbo

    2015-09-01

    Full Text Available Resumo: Este texto faz uma análise do modo historicista com que o historiador alemão Werner Jaeger, nas décadas de 1930 e 1940, aborda o homoerotismo grego (paiderastia e sua relação com a pedagogia em sua obra Paidéia, a formação do homem grego. Palavras-Chave: Homoerotismo Grego, Historicismo, Werner Jaeger Abstract: This text analyzes the historicist manner with which the German historian Werner Jaeger, in the 1930s and 1940s, addresses the Greek homoeroticism (paiderastia and its relation to pedagogy in his work Paideia, the ideals of the Greek culture. Keywords: Greek Homoerotiscism, Historicism, Werner Jaeger Recebido em: 069/08/2015  – Aceito em 10/09/2015

  10. From Editor vol 11, No.4

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2010-10-01

    Full Text Available Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 11, Number: 4. In this issue it is published 4 notes for Editor, 12 articles, 2 book and one conference reviews. And this time, 27 authors from 10 different countries are placed. These published articles are from Bangldesh, Greece, India, Israel, Malaysia, Nigeria, Portugal, Singapore, Turkey and USA.The first Notes for editor arrived from USA, written by Kevin YEE and Jace HARGIS. They focused on PREZI: A Different Way to Present. Prezi represents the first step toward other visual tools that are not, strictly speaking, and presentations at all, but may yet find uses in classrooms. Browser-based programs that allow for concept mapping and brainstorming (sometimes with drawing and even inter-user chat functionality approximate some of prezi’s best features yet stand on their own as organizing tools that provide inspiration for the users. Examples include bubble.us, Thinkature, Mindmeister, and Graphic Organizer. The second notes for editor is titled as “Investigating the Factor Structure ıf The Blog Attitude Scale” which is written by Zahra SHAHSAVAR, Tan Bee HOON, S. Vahid ARYADOUST from Malaysia. Their study reports the design and development of a blog attitude scale (BAS. In exploratory factor analysis, three factors were discovered: blog anxiety, blog desirability, and blog self-efficacy; 14 items were excluded. The extracted items were subjected to a confirmatory factor analysis which lent further support to the BAS underpinning structure. “Implementation of An Online Teacher Assessment/Appraisal In Technical Education Institution: A Case Study” is the third paper for “Notes for Editor” section of TOJDE’s in this issue. It has written by Sraboni MANDAL, Dr. SANJAY, Dajnish SHRIVASTAVA from National Institute of Technology, Jamshedpur, INDIA. The purpose to discusses a case study of implementation of teacher appraisal system which initially non

  11. Editors' Introduction: The Charge and the Challenge.

    Science.gov (United States)

    Grant, Carl A.; Graue, Elizabeth

    1997-01-01

    The new editors of the "Review of Educational Research" recognize their charge to be comprehensive in the process of review of educational research and to be of service to educators. They also acknowledge the challenge to be nurtured by the scholarship of the times and innovations in education. (SLD)

  12. Research Writing and NNSs: From the Editors.

    Science.gov (United States)

    Gosden, Hugh

    1992-01-01

    Varied linguistic and sociopragmatic skills required for effective international research reporting are discussed based on a survey of journal editors in North America and the United Kingdom. Emphasis is on language-related criteria that influence publication decisions, and suggestions are offered for teaching research writing. (17 references)…

  13. Graphical Editor of the DDS Topology Configuration

    CERN Document Server

    Rusinov, Aleksandar

    2015-01-01

    An editor for the DDS topology configuration is created to allow the viewing of an existing topology, the editing of a topology, the creation of a new topology and the saving of a topology as a topology language XML file to be run directly on DDS or to be reloaded again for further editing. The development of the editor was started at GSI Darmstadt at the end of last year. The editor is designed as a web application that works on the client side. Recent and powerful JavaScript libraries were used – ReactJS and JointJS. It has two menus for editing – one for the declarative part and another for the executable part. A graph visualisation of the topology has also been developed and implemented fully to the editor. The output files have been tested and fully verified on the DDS. Future work will involve representation of the pipeline process and investigation on behavior when larger and more sophisticated topologies are used.

  14. Editors, Teachers Disagree about Definition of Plagiarism.

    Science.gov (United States)

    Chaney, Jerry; Duncan, Tom

    1985-01-01

    Describes a study of plagiarism policies in journalism schools and newsrooms. Concludes that instructors felt educating students about plagiarism was one of the most important services journalism schools offer, but editors felt that plagiarism standards must be set in the real world of the newsroom. (HTH)

  15. From the Editor Vol: 6 number 2

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2005-04-01

    Full Text Available From the Editor Dear TOJDE’S Readers Time flies. Another quarter has begun. It is a great pleasure to welcome you to the 18th issue, the Volume: 6, Number: 2 of The Turkish Online Journal of Distance Education (TOJDE, of looking forward. TOJDE has been driving and shaping by our editorial board, reviewers, authors and even unbelievable readers. In the April 2005 issue, TOJDE publishes peer-reviewed distance education articles under four umbrellas: applications, feature topics, researches, and support systems. In addition, it publishes short and non-peer-reviewed book reviews and editorial letters. The main goal of TOJDE is to provide you with exclusive resources with the highest quality, and also to reach diverse audiences, as highly qualified individuals and researchers, around the world. Also, I am excited about that TOJDE is referenced as a course material by diverse institutions from the globe and very proud to share this news with you. You can see details in the news section. In this issue, it has been given place to two notes for editor submissions, eleven articles, two book reviews, 8 news, one journal about information and communication technology and one institution about technology integration via distance education named as RETA. And also interesting links deal with TOJDE take place in the literature. This issue's articles came from Canada, India, Malaysia, Nigeria, Turkey, United Kingdom and United States (according to alphabetical order. The first “Notes for Editors” is from Turkey on Using of Marketing Communication for Distance Education Institutions submitted by Dr. R. Ayhan YILMAZ, Anadolu University, Communication Sciences Faculty, Eskisehir, TURKEY. And second one arrived from India. It is titled as “Information and Communication Technology for Poverty Reduction” written by Motilal SHARMA. The first article came from Canada. It is entitled as “Understanding PISA” written by Dr. Stephen DOWNES. He mentions in his paper

  16. Heinz Werner: His Life, Ideas, and Contributions to Developmental Psychology in the First Half of the 20th Century.

    Science.gov (United States)

    Ostler, Teresa

    2016-01-01

    The author provides an overview of Heinz Werner's life and contributions to the field of developmental psychology during the first half of the 20th century. She focuses on his early work in Vienna and Munich as well as his tenure at the Psychological Institute in Hamburg, up through the time when he became a named Professor in Psychology at Clark University. Recognized as one of the founders of developmental psychology, Heinz Werner worked in the areas of perceptual development, comparative psychology, and symbol formation. Versatile in rigorous experimental methodologies, and in observational and phenomenological methodologies, Werner's approach to development stood in contrast to other approaches of development, both past and current. For Werner, development was a heuristic, a way of looking at processes in a variety of domains, including ontogeny, phylogeny, microgenesis, biology, developmental psychopathology, neuropsychology, and comparative psychology. Werner viewed development as proceeding from a state of relative globality and lack of differentiation to a state of increasing differentiation, articulation, and hierarchical integration, but he also stressed that individuals can function at different developmental levels under different times and conditions. Werner's holistic, organismic, comparative, and contextual approach to development transcended interdisciplinary boundaries, allowing him to study the interrelatedness between thought, language, feeling, perception, and culture.

  17. Quantum information transmission in the quantum wireless multihop network based on Werner state

    Science.gov (United States)

    Shi, Li-Hui; Yu, Xu-Tao; Cai, Xiao-Fei; Gong, Yan-Xiao; Zhang, Zai-Chen

    2015-05-01

    Many previous studies about teleportation are based on pure state. Study of quantum channel as mixed state is more realistic but complicated as pure states degenerate into mixed states by interaction with environment, and the Werner state plays an important role in the study of the mixed state. In this paper, the quantum wireless multihop network is proposed and the information is transmitted hop by hop through teleportation. We deduce a specific expression of the recovered state not only after one-hop teleportation but also across multiple intermediate nodes based on Werner state in a quantum wireless multihop network. We also obtain the fidelity of multihop teleportation. Project supported by the Prospective Future Network Project of Jiangsu Province, China (Grant No. BY2013095-1-18) and the Independent Project of State Key Laboratory of Millimeter Waves (Grant No. Z201504).

  18. WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations.

    Science.gov (United States)

    Friedrich, Katrin; Lee, Lin; Leistritz, Dru F; Nürnberg, Gudrun; Saha, Bidisha; Hisama, Fuki M; Eyman, Daniel K; Lessel, Davor; Nürnberg, Peter; Li, Chumei; Garcia-F-Villalta, María J; Kets, Carolien M; Schmidtke, Joerg; Cruz, Vítor Tedim; Van den Akker, Peter C; Boak, Joseph; Peter, Dincy; Compoginis, Goli; Cefle, Kivanc; Ozturk, Sukru; López, Norberto; Wessel, Theda; Poot, Martin; Ippel, P F; Groff-Kellermann, Birgit; Hoehn, Holger; Martin, George M; Kubisch, Christian; Oshima, Junko

    2010-07-01

    Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by null mutations at the WRN locus, which codes for a member of the RecQ family of DNA helicases. Since 1988, the International Registry of Werner syndrome had enrolled 130 molecularly confirmed WS cases from among 110 worldwide pedigrees. We now report 18 new mutations, including two genomic rearrangements, a deep intronic mutation resulting in a novel exon, a splice consensus mutation leading to utilization of the nearby splice site, and two rare missense mutations. We also review evidence for founder mutations among various ethnic/geographic groups. Founder WRN mutations had been previously reported in Japan and Northern Sardinia. Our Registry now suggests characteristic mutations originated in Morocco, Turkey, The Netherlands and elsewhere.

  19. OPM Scheme Editor 2: A graphical editor for specifying object-protocol structures

    Energy Technology Data Exchange (ETDEWEB)

    Chen, I-Min A.; Markowitz, V.M.; Pang, F.; Ben-Shachar, O.

    1993-07-01

    This document describes an X-window based Schema Editor for the Object-Protocol Model (OPM). OPM is a data model that supports the specification of complex object and protocol classes. objects and protocols are qualified in OPM by attributes that are defined over (associated with) value classes. Connections of object and protocol classes are expressed in OPM via attributes. OPM supports the specification (expansion) of protocols in terms of alternative and sequences of component (sub) protocols. The OPM Schema Editor allows specifying, displaying, modifying, and browsing through OPM schemas. The OPM Schema Editor generates an output file that can be used as input to an OPM schema translation tool that maps OPM schemas into definitions for relational database management systems. The OPM Schema Editor was implemented using C++ and the X11 based Motif toolkit, on Sun SPARCstation under Sun Unix OS 4.1. This document consists of the following parts: (1) A tutorial consisting of seven introductory lessons for the OPM Schema Editor. (2) A reference manual describing all the windows and functions of the OPM Schema Editor. (3) An appendix with an overview of OPM.

  20. Letter to editor Platelet volume evaluation in patients with sepsis ...

    African Journals Online (AJOL)

    2014-06-02

    Jun 2, 2014 ... collected for platelet indices and time interval between blood sampling and ... reliable MPV measurement, the potential influence of anticoagulant on the ... heart disease, metabolic syndrome, statin and some antihypertensive ...

  1. Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases.

    Science.gov (United States)

    Kudlow, Brian A; Kennedy, Brian K; Monnat, Raymond J

    2007-05-01

    Progeroid syndromes have been the focus of intense research in part because they might provide a window into the pathology of normal ageing. Werner syndrome and Hutchinson-Gilford progeria syndrome are two of the best characterized human progeroid diseases. Mutated genes that are associated with these syndromes have been identified, mouse models of disease have been developed, and molecular studies have implicated decreased cell proliferation and altered DNA-damage responses as common causal mechanisms in the pathogenesis of both diseases.

  2. Partial lipodystrophy with severe insulin resistance and adult progeria Werner syndrome.

    OpenAIRE

    Donadille, Bruno; D'Anella, Pascal; Auclair, Martine; Uhrhammer, Nancy; Sorel, Marc; Grigorescu, Romulus; Ouzounian, Sophie; Cambonie, Gilles; Boulot, Pierre; Laforêt, Pascal; Carbonne, Bruno; Christin-Maitre, Sophie; Bignon, Yves-Jean; Vigouroux, Corinne

    2013-01-01

    International audience; BACKGROUND: Laminopathies, due to mutations in LMNA, encoding A type-lamins, can lead to premature ageing and/or lipodystrophic syndromes, showing that these diseases could have close physiopathological relationships. We show here that lipodystrophy and extreme insulin resistance can also reveal the adult progeria Werner syndrome linked to mutations in WRN, encoding a RecQ DNA helicase. METHODS: We analysed the clinical and biological features of two women, aged 32 and...

  3. Proxima: a presentation-oriented editor for structured documents

    NARCIS (Netherlands)

    Schrage, M.M.

    2004-01-01

    A typical computer user deals with a large variety of documents, such as text files, spreadsheets, and web pages. The applications for constructing and modifying these documents are called editors (e.g. text editors, spreadsheet applications, and HTML editors). Despite the apparent differences betwe

  4. Schrödinger cat and Werner state disentanglement simulated by trapped ion systems

    Science.gov (United States)

    Bittencourt, Victor A. S. V.; Bernardini, Alex E.

    2017-04-01

    Disentanglement and loss of quantum correlations due to one global collective noise effect are described for two-qubit Schrödinger cat and Werner states of a four level trapped ion quantum system. Once the Jaynes–Cummings ionic interactions are mapped onto a Dirac spinor structure, the elementary tools for computing quantum correlations of two-qubit ionic states are provided. With two-qubit quantum numbers related to the total angular momentum and to its projection onto the direction of an external magnetic field (which lifts the degeneracy of the ion’s internal levels), a complete analytical profile of entanglement for the Schrödinger cat and Werner states is obtained. Under vacuum noise (during spontaneous emission), the two-qubit entanglement in the Schrödinger cat states is shown to vanish asymptotically. Otherwise, the robustness of Werner states is concomitantly identified, with the entanglement content recovered by their noiseless-like evolution. Most importantly, our results point to a firstly reported sudden transition between classical and quantum decay regimes driven by a classical collective noise on the Schrödinger cat states, which has been quantified by the geometric discord.

  5. Stereochemistry of coordination compounds. From alfred werner to the 21st century.

    Science.gov (United States)

    von Zelewsky, Alex

    2014-01-01

    As a contribution to the scientific symposium, November 22nd, 2013, commemorating the Nobel Prize awarded to Alfred Werner in 1913, a presentation of the development of stereochemistry of coordination compounds during the past 120 years was given. Stereochemistry was fundamental to Werner's theory of coordination compounds. After Werner's death in 1919, stereochemistry in this field did not progress much further for almost 20 years, but then developed continuously. It was realized that stereochemical features of elements showing coordination numbers larger than four are responsible for an almost unlimited number of stereochemical possibilities, thus opening a molecular world of new structures. In the beginning of the 21st century, interest in the field rose again considerably, mainly due to the potential of stereoselective catalysis, and the self-assembly of supramolecular structures. An end of these developments is not in sight. Here an abbreviated version of the lecture is given. A PowerPoint(®) file, or a video of the presentation, can be downloaded.

  6. Evolutionary theory in letters to the editor.

    Science.gov (United States)

    Silva, Eric Orion; Lowe, Clayton Cory

    2015-05-01

    This research note presents the results of a content analysis of 234 letters to the editors that discuss evolutionary theory and were published in American newspapers. We find that letters to the editor both support and hinder the cause of teaching evolutionary theory in American secondary schools. On the one hand, anti-evolutionary theory messages are marginalized in the letters section. This marginalization signals a low level of legitimacy for creationism. It might also contribute to the sense of tension that sustains creationist identities. On the other hand, relatively few letters explicitly note the fact that scientists or the scientific community accept evolution. Interestingly, the obscuration of the scientific community's support for evolutionary theory occurs both in letters supporting and opposing evolutionary theory. © The Author(s) 2014.

  7. From the editors:special issue announcement

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ We wish to sincerely thank Professor Li jianzhong of Tongji University and Professor Ian Buckle of the University of Nevada at Reno,for acting as guest editors of our first special issue on the"Seismic Design and Retrofit of Highway Bridges."These two well-known experts in the field have helped to provide ten papers on a variety of topics important in bridge engineering today.

  8. Workbench surface editor of brain cortical surface

    Science.gov (United States)

    Dow, Douglas E.; Nowinski, Wieslaw L.; Serra, Luis

    1996-04-01

    We have developed a 3D reach-in tool to manually reconstruct 3D cortical surface patches from 2D brain atlas images. The first application of our cortex editor is building 3D functional maps, specifically Brodmann's areas. This tool may also be useful in clinical practice to adjust incorrectly mapped atlas regions due to the deforming effect of lesions. The cortex editor allows a domain expert to control the correlation of control points across slices. Correct correlation has been difficult for 3D reconstruction algorithms because the atlas slices are far apart and because of the complex topology of the cortex which differs so much from slice to slice. Also, higher precision of the resulting surfaces is demanded since these define 3D brain atlas features upon which future stereotactic surgery may be based. The cortex editor described in this paper provides a tool suitable for a domain expert to use in defining the 3D surface of a Brodmann's area.

  9. The editor-referee system and publication an editor's view of the process

    Science.gov (United States)

    Shore, S. N.

    2011-07-01

    This chapter explains the functioning of scientific journals from the editorial side of the process. Both the history and current functioning of scientific journals are reviewed with a particular emphasis on the evolution of the referee's role. In its current form, the evaluation of a submission is interactive between the three parties - the author(s), editors, and reviewers. The editors serve as the mediators and final evaluators, seeking advice from one or more contacted experts who are in the special position of evaluating the science, presentation, and significance of the work. The chapter explains how this proceeds, and its advantages, pitfalls, and criteria - scientific, archival, and ethical - and how these have evolved historically and consensually. Since referees and editors are also authors, the symbiosis of the process is one of its strengths, since all participants exchange roles.

  10. K. C. Yeh: Radio Science Editor

    Science.gov (United States)

    Advances in satellite technology and computer science have had the greatest impact on radio science in the last quarter century, according to Kung Chie Yeh, the new editor of Radio Science. Yeh, whose term began July 1 (Eos, April 12, 1983, p. 137, February 22, 1983, p. 73), is a professor in the electrical engineering department at the University of Illinois at Urbana-Champaign.An international authority on ionospheric radio physics, Yeh also is known for his work on trans-ionospheric radio wave propagation as it affects earth-space communications and satellite navigation. Hehas been studying radio science for nearly 30 years.

  11. MPS Editor - An Integrated Sequencing Environment

    Science.gov (United States)

    Streiffert, Barbara A.; O'Reilly, Taifun; Schrock, Mitchell; Catchen, Jaime

    2010-01-01

    In today's operations environment, the teams are smaller and need to be more efficient while still ensuring the safety and success of the mission. In addition, teams often begin working on a mission in its early development phases and continue on the team through actual operations. For these reasons the operations teams want to be presented with a software environment that integrates multiple needed software applications as well as providing them with context sensitive editing support for entering commands and sequences of commands. At Jet Propulsion Laboratory, the Multi-Mission Planning and Sequencing (MPS) Editor provided by the Multi-Mission Ground Systems and Services (MGSS) supports those operational needs.

  12. Meet the Editor: Global Biogeochemical Cycles

    Science.gov (United States)

    Kumar, Mohi

    Meinrat Andreae was named the editor of the AGU's journal Global Biogeochemical Cycles last year.Andreae, director of the biogeochemistry department at the Max Plank Institute for Chemistry (MPIC), located in Mainz, Germany said that he plans to maintain the journal as a resource that highlights the broad spectrum of interdisciplinary themes that showcase the interactions between the biosphere and the geosphere. “Our special niche is in the field of larger-scale, more integrative studies that have global scope,” he explained.

  13. Síndrome de Werner associada a quadro esclerodermiforme: relato de caso e revisão da literatura Werner's syndrome associated with scleroderma-like syndrome: case report and literature revision

    Directory of Open Access Journals (Sweden)

    Cristiane Kayser

    2008-04-01

    Full Text Available A síndrome de Werner é uma doença autossômica recessiva rara associada a envelhecimento precoce, cujo quadro cutâneo deve ser distinguido daquele encontrado na esclerose sistêmica (ES. Descrevemos aqui o caso de uma paciente de 39 anos de idade, portadora de síndrome de Werner, encaminhada ao nosso serviço com hipótese diagnóstica inicial de ES. A paciente apresentava várias manifestações associadas à síndrome de Werner, incluindo cabelos precocemente grisalhos, voz estridente, baixa estatura, alterações cutâneas esclerodermiformes, diabetes melito, catarata, hipogonadismo, hipotireoidismo e hiperlipidemia. Não apresentava fenômeno de Raynaud, manifestações viscerais típicas da ES, alterações capilaroscópicas periungueais ou auto-anticorpos. O diagnóstico de síndrome de Werner, apesar de raro, deve ser lembrado no diagnóstico diferencial de ES, principalmente na presença de manifestações atípicas e na ausência de alterações típicas da ES.Werner's syndrome is a rare autosomal recessive disease associated with premature ageing. Skin alteration must be distinguished from cutaneous manifestation of systemic sclerosis (SSc. We describe a case of a 39 years old patient with Werner's syndrome admitted with an initial diagnostic hypothesis of SSc. The patient had many characteristic features associated with Werner's syndrome including gray hair, hoarseness, short stature, scleroderma-like skin changes, diabetes mellitus, cataracts, hypogonadism, hypothyroidism, and hyperlipidemia. There was no Raynaud's phenomenon, other typical visceral manifestation of SSc, nailfold capillary alterations or autoantibodies. Werner's syndrome diagnosis notwithstanding rare, should be remember in the differential diagnosis of SSc, mainly in the presence of atypical manifestations and in the absence of typical features of SSc.

  14. A new tool for modeling dune field evolution based on an accessible, GUI version of the Werner dune model

    Science.gov (United States)

    Barchyn, Thomas E.; Hugenholtz, Chris H.

    2012-02-01

    Research into aeolian dune form and dynamics has benefited from simple and abstract cellular automata computer models. Many of these models are based upon a seminal framework proposed by Werner (1995). Unfortunately, most versions of this model are not publicly available or are not provided in a format that promotes widespread use. In our view, this hinders progress in linking model simulations to empirical data (and vice versa). To this end, we introduce an accessible, graphical user interface (GUI) version of the Werner model. The novelty of this contribution is that it provides a simple interface and detailed instructions that encourage widespread use and extension of the Werner dune model for research and training purposes. By lowering barriers for researchers to develop and test hypotheses about aeolian dune and dune field patterns, this release addresses recent calls to improve access to earth surface models.

  15. Vom Hören der Sphärenharmonie in Werner Schulzes "Sokrates"

    OpenAIRE

    Molina Moreno, Francisco

    2003-01-01

    El compositor, pensador, investigador y profesor de la Universidad para la Música y las Artes Escénicas de Viena, Werner Schulze, es autor de un drama con música sobre la vida y personalidad de Sócrates. El soporte verbal del drama lo constituyen pasajes de Platón y Aristófanes, en su versión original en griego antiguo. La obra incluye una evocación musical del mito de Er, al final de la "República" de Platón, que constituye el primer testimonio griego de la música de las esferas. En este tra...

  16. Werner Aisslinger 环保可以如此前卫

    Institute of Scientific and Technical Information of China (English)

    岳彬

    2011-01-01

    当生态环保成为绝大多数设计师作秀的噱头时,Werner Aisslinger对其的设计理解已经超越了简单意义上的材质"绿色"。他以简洁和实用的设计理念,来确保环保设计的纯粹性,设计作品很多都充满了现代主义色彩。

  17. Communicating specialized knowledge - negotiating knowledge communication between writer and editor

    DEFF Research Database (Denmark)

    Petersen, Margrethe

    In communicating research findings, authors of academic journal articles face the challenge of overcoming the barriers posed by the knowledge asymmetries between (a) authors and journal readership and (b) authors and editors. Considering the general taxonomy of the submission procedure and the key...... role of academic journal editors, the issue of whether, regardless of the quality of the submissions received, editors are sometimes insurmountable barriers to knowledge communication should be debated....

  18. Highlighting Impact and the Impact of Highlighting: PRB Editors' Suggestions

    CERN Document Server

    Antonoyiannakis, Manolis

    2016-01-01

    Associate Editor Manolis Antonoyiannakis discusses the highlighting, as Editors' Suggestions, of a small percentage of the papers published each week. We highlight papers primarily for their importance and impact in their respective fields, or because we find them particularly interesting or elegant. It turns out that the additional layer of scrutiny involved in the selection of papers as Editors' Suggestions is associated with a significantly elevated and sustained citation impact.

  19. A Tisket, A Tasket--Out of the Editor's Basket

    Science.gov (United States)

    Williams, Kathryn R.

    2001-05-01

    In September 1940, the Journal introduced Out of the Editor's Basket for short items of interest: excerpts from letters, pamphlets, newspapers, and periodicals. By 1950, however, the Editor's Basket had evolved into a bulletin board for descriptions of new products and services, and it now contains almost exclusively press releases about recently marketed items. Now over 60 years old, the Editor's Basket still provides interesting tidbits for the Journal's broad readership.

  20. From the Board of Editors: on Plagiarism

    Science.gov (United States)

    2005-05-01

    Dear Colleagues: There has been a significant increase in the number of duplicate submissions and plagiarism cases reported in all major journals, including the journals of the Optical Society of America. Duplicate submissions and plagiarism can take many forms, and all of them are violations of professional ethics, the copyright agreement that an author signs along with the submission of a paper, and OSA's published Author Guidelines. There must be a significant component of new science for a paper to be publishable. The copying of large segments of text from previously published or in-press papers with only minor cosmetic changes is not acceptable and can lead to the rejection of papers. Duplicate submission: Duplicate submission is the most common ethics violation encountered. Duplicate submission is the submission of substantially similar papers to more than one journal. There is a misperception in a small fraction of the scientific community that duplicate submission is acceptable because it sometimes takes a long time to get a paper reviewed and because one of the papers can be withdrawn at any time. This is a clear violation of professional ethics and of the copyright agreement that is signed on submission. Duplicate submission harms the whole community because editors and reviewers waste their time and in the process compound the time it takes to get a paper reviewed for all authors. In cases of duplicate submission, the Editor of the affected OSA journal will consult with the Editor of the other journal involved to determine the proper course of action. Often that action will be the rejection of both papers. Plagiarism: Plagiarism is a serious breach of ethics and is defined as the substantial replication, without attribution, of significant elements of another document already published by the same or other authors. Two types of plagiarism can occur-self-plagiarism and plagiarism from others' works. Self-plagiarism is the publication of substantially

  1. Web-Based Media Contents Editor for UCC Websites

    Science.gov (United States)

    Kim, Seoksoo

    The purpose of this research is to "design web-based media contents editor for establishing UCC(User Created Contents)-based websites." The web-based editor features user-oriented interfaces and increased convenience, significantly different from previous off-line editors. It allows users to edit media contents online and can be effectively used for online promotion activities of enterprises and organizations. In addition to development of the editor, the research aims to support the entry of enterprises and public agencies to the online market by combining the technology with various UCC items.

  2. Letter from the New Editor-in-Chief

    Directory of Open Access Journals (Sweden)

    Pabulo Henrique Rampelotto

    2014-01-01

    Full Text Available It is my great pleasure to serve as the new Editor-in-Chief of Life, a journal concerned with fundamental questions on the origins and nature of life, evolution of biosystems and astrobiology. With my experience as Executive Editor, Senior Editor and Guest Editor of so many successful special issues (some of them in MDPI journals [1–6], I am committed to making the journal a success, with the launch of exciting special issues, publication of high quality papers, as well as inclusion of the journal in major indexing and abstracting services. In this editorial, I present my view and plans for the journal.

  3. The 21-cm signature of the first stars during the Lyman-Werner feedback era

    CERN Document Server

    Fialkov, Anastasia; Visbal, Eli; Tseliakhovich, Dmitriy; Hirata, Christopher M

    2012-01-01

    The formation of the first stars is an exciting frontier area in astronomy. Early redshifts z ~ 20 have become observationally promising as a result of a recently recognized effect of a supersonic relative velocity between the dark matter and gas. This effect produces prominent structure on 100 comoving Mpc scales, which makes it much more feasible to detect 21-cm fluctuations from the epoch of first heating. We use semi-numerical hybrid methods to follow for the first time the joint evolution of the X-ray and Lyman-Werner radiative backgrounds, including the effect of the supersonic streaming velocity on the cosmic distribution of stars. We incorporate self-consistently the negative feedback on star formation induced by the Lyman-Werner radiation, which dissociates molecular hydrogen and thus suppresses gas cooling. We find that the feedback delays the X-ray heating transition by a Delta z ~ 2, but leaves a promisingly large fluctuation signal over a broad redshift range. The large-scale power spectrum is pr...

  4. First Japanese case of atypical progeroid syndrome/atypical Werner syndrome with heterozygous LMNA mutation.

    Science.gov (United States)

    Motegi, Sei-ichiro; Yokoyama, Yoko; Uchiyama, Akihiko; Ogino, Sachiko; Takeuchi, Yuko; Yamada, Kazuya; Hattori, Tomoyasu; Hashizume, Hiroaki; Ishikawa, Yuichi; Goto, Makoto; Ishikawa, Osamu

    2014-12-01

    Atypical progeroid syndrome (APS), including atypical Werner syndrome (AWS), is a progeroid syndrome involving heterozygous mutations in the LMNA gene encoding the nuclear protein lamin A/C. We report the first Japanese case of APS/AWS with a LMNA mutation (p.D300N). A 53-year-old Japanese man had a history of recurrent severe cardiovascular diseases as well as brain infarction and hemorrhages. Although our APS/AWS patient had overlapping features with Werner syndrome (WS), such as high-pitched voice, scleroderma, lipoatrophy and atherosclerosis, several cardinal features of WS, including short stature, premature graying/alopecia, cataract, bird-like face, flat feet, hyperkeratosis on the soles and diabetes mellitus, were absent. In immunofluorescence staining and electron microscopic analyses of the patient's cultured fibroblasts, abnormal nuclear morphology, an increase in small aggregation of heterochromatin and a decrease in interchromatin granules in nuclei of fibroblasts were observed, suggesting that abnormal nuclear morphology and chromatin disorganization may be associated with the pathogenesis of APS/AWS.

  5. POLD1 Germline Mutations in Patients Initially Diagnosed with Werner Syndrome.

    Science.gov (United States)

    Lessel, Davor; Hisama, Fuki M; Szakszon, Katalin; Saha, Bidisha; Sanjuanelo, Alexander Barrios; Salbert, Bonnie A; Steele, Pamela D; Baldwin, Jennifer; Brown, W Ted; Piussan, Charles; Plauchu, Henri; Szilvássy, Judit; Horkay, Edit; Högel, Josef; Martin, George M; Herr, Alan J; Oshima, Junko; Kubisch, Christian

    2015-11-01

    Segmental progeroid syndromes are rare, heterogeneous disorders characterized by signs of premature aging affecting more than one tissue or organ. A prototypic example is the Werner syndrome (WS), caused by biallelic germline mutations in the Werner helicase gene (WRN). While heterozygous lamin A/C (LMNA) mutations are found in a few nonclassical cases of WS, another 10%-15% of patients initially diagnosed with WS do not have mutations in WRN or LMNA. Germline POLD1 mutations were recently reported in five patients with another segmental progeroid disorder: mandibular hypoplasia, deafness, progeroid features syndrome. Here, we describe eight additional patients with heterozygous POLD1 mutations, thereby substantially expanding the characterization of this new example of segmental progeroid disorders. First, we identified POLD1 mutations in patients initially diagnosed with WS. Second, we describe POLD1 mutation carriers without clinically relevant hearing impairment or mandibular underdevelopment, both previously thought to represent obligate diagnostic features. These patients also exhibit a lower incidence of metabolic abnormalities and joint contractures. Third, we document postnatal short stature and premature greying/loss of hair in POLD1 mutation carriers. We conclude that POLD1 germline mutations can result in a variably expressed and probably underdiagnosed segmental progeroid syndrome.

  6. From Editor vol 11, No.3

    Directory of Open Access Journals (Sweden)

    Ugur Demiray

    2010-07-01

    Full Text Available Greetings Dear readers of TOJDE,TOJDE is appeared on your screen now as Volume 11, Number: 3. In this issue it is published 3 notes for Editor, 12 articles, 2 book reviews. And this time, 32 authors from 10 different countries are placed. These published articles are from Barbados, Ghana, Iran, Malaysia, Pakistan, Spain, Turkey, United Kingdom, UAE and USA.“Developing and Validation A Usability Evaluation Tools For Distance Education Websites:Persian Version” has sent as Notes for editor section of TOJDE from Iran and written by Soheila HAFEZI, Ahmad FARAHI from Payame Noor University and Soheil Najafi MEHRI, Hosein MAHMOODI from Baqiyatallah Medical Sciences University, Tehran.. Their paper involves that he content validity index was measured by set of ten experts, who evaluated each item individually. According to CVI, the final version of instrument was composed of 40 questions divided into 8 domains: Navigation, Functionality, Feedback, Control, Language, Consistency, Error prevention and correction, and Visual clarity. CVI score for each phrase was more than 0.75. According to our findings, this instrument has enough validity to apply in evaluation usability of educational websites of Persian distance education websites. However, instrument reliability can be measured in further study. The second notes for editor is titled as “A Critical Analysis Of Managerial Skills Competencies Of Secondary School Heads Trained Through Distance Mode of Allama Iqbal Open University” which is written by Muhammad AKHLAQ from Preston University, Islamabad, PAKISTAN and SHAZIA MUNAWAR SULEHRI from Ministry of Education, PAKISTAN. They mentioned in their paper to analyze the managerial skills competencies of secondary schools heads trained through distance mode of education in Pakistan. For this purpose a sample 300 secondary school teachers and 100 secondary schools head-teachers trained through distance mode and working in the Federal Government

  7. Highlighting Kathleen Green and Mario Delmar, guest editors of special issue (part 2): junctional targets of skin and heart disease.

    Science.gov (United States)

    Cowin, Pamela

    2014-06-01

    Cell Communication and Adhesion has been fortunate to enlist two pioneers of epidermal and cardiac cell junctions, Kathleen Green and Mario Delmar, as Guest Editors of a two part series on junctional targets of skin and heart disease. Part 2 of this series begins with an overview from Dipal Patel and Kathy Green comparing epidermal desmosomes to cardiac area composita junctions, and surveying the pathogenic mechanisms resulting from mutations in their components in heart disease. This is followed by a review from David Kelsell on the role of desmosomal mutation in inherited syndromes involving skin fragility. Agnieszka Kobeliak discusses how structural deficits in the epidermal barrier intersect with the NFkB signaling pathway to induce inflammatory diseases such as psoriasis and atopic dermatitis. Farah Sheikh reviews the specialized junctional components in cardiomyocytes of the cardiac conduction system and Robert Gourdie discusses how molecular complexes between sodium channels and gap junction proteins within the perijunctional microdomains within the intercalated disc facilitate conduction. Glenn Radice evaluates the role of N-cadherin in heart. Andre Kleber and Chris Chen explore new approaches to study junctional mechanotransduction in vitro with a focus on the effects of connexin ablation and the role of cadherins, respectively. To complement this series of reviews, we have interviewed Werner Franke, whose systematic documentation the tissue-specific complexity of desmosome composition and pioneering discovery of the cardiac area composita junction greatly facilitated elucidation of the role of desmosomal components in the pathophysiology of human heart disease.

  8. From the editors: special issue announcement

    Institute of Scientific and Technical Information of China (English)

    XiaozhaiQi; George C.Lee

    2008-01-01

    @@ This issue contains the first paper on lessons leamed from the Great Wenchuan Earthquake that JEEEV hopes to continue to provide to our readers. We welcome contributions for consideration for future publication. During the past several months, we have been considering "Special Issues" on a variety of topics for the journal ofEarthquake Engineering and Engineering Vibration. We are pleased to announce that the December 2008 issue will befocused on "Seismic Design and Retrofit of Highway Bridges," with Professor Li Jianzhong of Tongji University andProfessor Ian Buckle of the University of Nevada at Reno serving as Guest Editors. We invite you to contribute to thisSpecial Issue by submitting a manuscript to either our Harbin or Buffalo office by August 15, 2008 with an indication"For 2008 Special Issue."

  9. Editors Discuss Women’s Publications

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    IT was only about ten years ago that there were only a few of newspapers and periodicals about women in China. But China has seen a rapid development of newspapers and periodicals on women since it began the policy of reform and opening to the outside world. Today the All-China Women’s Federation and local women’s federations sponsor and publish 47 different publications about women and children, some of which have a circulation of more than one million. These colorful, influential women’s newspapers and periodicals are now some of the most interesting publications in China. Why have these publications been so successful? Recently our staff reporter interviewed several women chief editors about their work. The following interviews are in their own words.

  10. From the Editor-in-Chief

    Directory of Open Access Journals (Sweden)

    Simeon Oka

    2010-01-01

    Full Text Available The Editorial Board of the journal Thermal Science is continuing to pay great attention to the processes in internal combustion engines, both due to their environmental impact and ability to use renewable energy sources i. e. different types of biofuels. Concerning that motor vehicles contribute about 14% of the global CO2 emission, it is understandable that many research efforts are devoted to processes in internal combustion engines and use of biofuels. The number of submitted papers dealing with processes in internal combustion engines is growing from months to months, so in the journal Thermal Science also will published in 2011 one issue devoted to the same topics. Papers submitted are already in the reviewing process. Professor Dragoslava Stojiljkovi} and Professor Stojan Petrovi} as Guest editors, had again a difficult task to make appropriate choice of the papers, covering wide range of topics. I am very grateful to Guest editors for their extremely competent choice of the topics and papers. Reviewers of the papers made, also, tremendous contributions to the quality of the papers published. This time, also, as in No. 3, 2009, we asked experts in traffic engineering to give their contribution. They pointed out importance of the internal combustion engine energy efficiency, vehicle fleet operation management and logistic efficiency, and painted large scale picture of the environmental problems caused by large density traffic. We hope that this point of view will make new impulse for many new joint projects with the aim to investigate impact of the processes in internal combustion engines and logistic of motor fleet management, and organization of traffic flows, especially in large towns, on environment. Papers devoted to the thermal processes in internal combustion engines are grouped in Part one of this issue. Due to large number of papers accepted for publication, we have been forced to introduce Part two, in which are grouped selected

  11. Domain-Specific Languages for Composable Editor Plugins

    NARCIS (Netherlands)

    Kats, L.C.L.; Kalleberg, K.T.; Visser, E.

    2009-01-01

    This paper is a pre-print of: Lennart C. L. Kats, Karl T. Kalleberg, Eelco Visser. Domain-Specific Languages for Composable Editor Plugins. In T. Ekman and J. Vinju, editors, Proceedings of the Ninth Workshop on Language Descriptions, Tools, and Applications (LDTA’09), Electronic Notes in Theoretica

  12. The RAE and Publications: A Review of Journal Editors.

    Science.gov (United States)

    Talib, Ameen Ali

    2000-01-01

    Surveyed editors of academic journals about publication issues related to Britain's Research Assessment Exercise (RAE), a process of grading and funding universities based on published research output. Editors were asked about research quality and output, publication practices, academics' willingness to referee manuscripts, and proliferation of…

  13. Journal Editor Perceptions of Universities: Some Empirical Evidence

    Science.gov (United States)

    Mainardes, Emerson Wagner; Raposo, Mario; Alves, Helena

    2012-01-01

    Out of considerations as to the importance of university relationships with their various stakeholders, the primary objective of this research project was to identify the perceptions of academic journal editors regarding universities. Editors were asked to provide their perceptions on: (a) the relevance of universities to academic publications;…

  14. Peer reviews and the role of a journal editor

    Science.gov (United States)

    Obtaining peer reviews for manuscripts submitted to scientific journals is becoming increasingly difficult. Changes to the system are necessary, and editors must cultivate and maintain a solid base of reviewers to help evaluate journal submissions. This article outlines some steps editors can and sh...

  15. Object class hierarchy for an incremental hypertext editor

    Directory of Open Access Journals (Sweden)

    A. Colesnicov

    1995-02-01

    Full Text Available The object class hierarchy design is considered due to a hypertext editor implementation. The following basic classes were selected: the editor's coordinate system, the memory manager, the text buffer executing basic editing operations, the inherited hypertext buffer, the edit window, the multi-window shell. Special hypertext editing features, the incremental hypertext creation support and further generalizations are discussed.

  16. How Managing Editors View and Deal with Newspaper Ethical Issues.

    Science.gov (United States)

    Anderson, Douglas

    1987-01-01

    Claims there is awareness and concern about journalism ethics among daily newspaper managing editors. Asserts that although ethical issues are being addressed to some degree, greater efforts could be made to see that reporters and editors are apprised of codes of ethics. (MM)

  17. A simple approach for building transliteration editors for Indian languages

    Institute of Scientific and Technical Information of China (English)

    PRAHALLAD Lavanya; PRAHALLAD Kishore; GANAPATHIRAJU Madhavi

    2005-01-01

    Transliteration editors are essential for keying-in Indian language scripts into the computer using QWERTY keyboard.Applications of transliteration editors in the context of Universal Digital Library (UDL) include entry of meta-data and dictionaries for Indian languages. In this paper we propose a simple approach for building transliteration editors for Indian languages using Unicode and by taking advantage of its rendering engine. We demonstrate the usefulness of the Unicode based approach to build transliteration editors for Indian languages, and report its advantages needing little maintenance and few entries in the mapping table, and ease of adding new features such as adding letters, to the transliteration scheme. We demonstrate the transliteration editor for 9 Indian languages and also explain how this approach can be adapted for Arabic scripts.

  18. Representation of women as editors in the Cochrane collaboration.

    Science.gov (United States)

    Bhaumik, Soumyadeep; Mathew, Rebecca Joyce

    2014-12-01

    There is considerable gender disparity in editorial boards of medical journals. Being an editor in a Cochrane review group (CRG), like being an editor in a medical journal, is an indirect representation of one's reputation and leadership abilities in a particular specialty. The aim of the study was to analyze the representation of women editors on the editorial teams of CRG's and the Central Editorial Unit (CEU) of the Cochrane Collaboration. Information about editorial team members of CRGs and the CEU was extracted from respective websites. Gender of the individual was determined by inspection of names, individual profile description or photographs in the CRG or institutional webpage, social networking sites and internet search. Data was validated by two authors independently and differences sorted by consensus. A total of 788 editors across all CRGs and the CEU with an overall 371 females (47.1%) and 417 (52.9%) males were identified. of the CEU editors, 62.5% were females. There were 68 coordinating editors (35.3% females), and 62 managing editors (56% females), who provided leadership to the CRGs. Eighty-four percent of trial search coordinators were found to be females. Ten CRGs had 75% or more of its editors as females while 7 CRGs had less than or equal to 25% female editors. The representation of women editors in the Cochrane Collaboration was found to be better than in editorial boards of medical journals. There is still scope for improvement to ensure better gender diversity across all roles and in all CRG's. © 2014 Chinese Cochrane Center, West China Hospital of Sichuan University and Wiley Publishing Asia Pty Ltd.

  19. JSME: a free molecule editor in JavaScript.

    Science.gov (United States)

    Bienfait, Bruno; Ertl, Peter

    2013-01-01

    A molecule editor, i.e. a program facilitating graphical input and interactive editing of molecules, is an indispensable part of every cheminformatics or molecular processing system. Today, when a web browser has become the universal scientific user interface, a tool to edit molecules directly within the web browser is essential. One of the most popular tools for molecular structure input on the web is the JME applet. Since its release nearly 15 years ago, however the web environment has changed and Java applets are facing increasing implementation hurdles due to their maintenance and support requirements, as well as security issues. This prompted us to update the JME editor and port it to a modern Internet programming language - JavaScript. The actual molecule editing Java code of the JME editor was translated into JavaScript with help of the Google Web Toolkit compiler and a custom library that emulates a subset of the GUI features of the Java runtime environment. In this process, the editor was enhanced by additional functionalities including a substituent menu, copy/paste, drag and drop and undo/redo capabilities and an integrated help. In addition to desktop computers, the editor supports molecule editing on touch devices, including iPhone, iPad and Android phones and tablets. In analogy to JME the new editor is named JSME. This new molecule editor is compact, easy to use and easy to incorporate into web pages. A free molecule editor written in JavaScript was developed and is released under the terms of permissive BSD license. The editor is compatible with JME, has practically the same user interface as well as the web application programming interface. The JSME editor is available for download from the project web page http://peter-ertl.com/jsme/

  20. Metal Vector Manipulated Molecular Self-Assembly from Werner System to Cotton System

    Institute of Scientific and Technical Information of China (English)

    YU Shu-Yan; ZHANG Zhong-Xing; HUANG Hui; LI Sheng-Hui; HUANG Hai-Ping

    2004-01-01

    A definition of metal vector was given to coordinatively unsaturated metals or asymmetrically coordinated metal complexes in which the metal center is partly blocked by inert chelating ligand(s), thus possess specific reactivity and directionality, such as cis-coordinated square Pd(Ⅱ) or Pt(Ⅱ) complexes. Metal vectors have been extensively used in coordination catalysis and molecular assembly. In 1990, Fujita [ 1 ] first demonstrated the utility of cis-coordinated square Pd(Ⅱ)or Pt(Ⅱ) complexes as a right angular 2D metal vector in the formation of molecular square, a cyclic tetramer with nano-cavity and unique molecular recognition. So far, much attention has been paid to the use of the mononuclear coordination centers (Werner-type metal vectors) in molecular assembly.As late as 1999, Cotton et al. [2] reported the use of cis-coordinated metal-metal bonded dimetal units (Cotton-type metal vectors) to direct assembly of molecular squares.This presentation includes two parts: 1) Werner-type metal vector directed molecular assembly; [3]2) Cotton-type metal vector directed molecular assembly.[4]Firstly, the Werner-type metal vector, cis-coordinated Pd(Ⅱ) nitrate, was used to direct a 6-component self-assembly. This leads to the formation of a molecular bowl or crown with syn,syn,syn conformation. These structures are analogues of calix[3]arenes and can function as anion receptors. Interestingly, an nitrate is found to distort from a trigonal plane into a trigonal pyramid when binding to the bottom of the molecular bowl.Secondly, the Cotton-type metal vector, cis-diRh(Ⅱ, Ⅱ), was used to assemble di- or poly-carboxylate anions into neutral supermolecules. Most interestingly, a calixarene-based carceplex with four cis-diRh(Ⅱ, Ⅱ) fastners was obtained[5].All self-assembling entities were studied by both X-ray crystallographic analysis and solution NMR spectra, which are consistent with the presence of assembling structures even in solution.

  1. Martin Stutzmann: Editor, Teacher, Scientist and Friend

    Science.gov (United States)

    Cardona, Manuel

    2005-03-01

    On 2 January 1995 Martin Stutzmann became Editor-in-Chief of physica status solidi, replacing Professor E. Gutsche, who had led the journal through the stormy period involving the fall of the Iron Curtain, the unification of Germany and the change in its Eastern part, where physica status solidi was based, from socialism as found in the real world (a German concept) to real world capitalism. In 1995 it was thought that the process had been completed (we should have known better!) and after the retirement of Prof. Gutsche the new owners of physica status solidi (Wiley-VCH) decided that a change in scientific management was desirable to adapt to the new socio-political facts and to insure the scientific continuity of the journal.Martin had moved in 1993 from my department at the Max-Planck-Institute to Munich where he soon displayed a tremendous amount of science man- agement ability during the build-up of the Walter Schottky Institute. The search for a successor as Edi- tor-in-Chief was not easy: the job was not very glamorous after the upheavals which had taken place in the editorial world following the political changes. Somebody in the Editorial Boards must have suggested Martin Stutzmann. I am sure that there was opposition: one usually looks for a well-established person ready to leave his direct involvement in science and take up a new endeavor of a more administrative nature. Nevertheless, the powers that be soon realized that Martin was an excellent, if somewhat unconventional candidate who had enough energy to remain a topnotch scientist and to lead the journal in the difficult times ahead: he was offered the job. In the negotiations that followed, he insisted in getting the administrative structures that would allow him to improve the battered quality of the journal and to continue his scientific productivity. Today we are happy to see that he succeeded in both endeavors. The journal has since grown in size and considerably improved its quality

  2. Martin Stutzmann: Editor, Teacher, Scientist and Friend

    Science.gov (United States)

    Cardona, Manuel

    2005-02-01

    On 2 January 1995 Martin Stutzmann became Editor-in-Chief of physica status solidi, replacing Professor E. Gutsche, who had led the journal through the stormy period involving the fall of the Iron Curtain, the unification of Germany and the change in its Eastern part, where physica status solidi was based, from socialism as found in the real world (a German concept) to real world capitalism. In 1995 it was thought that the process had been completed (we should have known better!) and after the retirement of Prof. Gutsche the new owners of physica status solidi (Wiley-VCH) decided that a change in scientific management was desirable to adapt to the new socio-political facts and to insure the scientific continuity of the journal.Martin had moved in 1993 from my department at the Max-Planck-Institute to Munich where he soon displayed a tremendous amount of science man- agement ability during the build-up of the Walter Schottky Institute. The search for a successor as Edi- tor-in-Chief was not easy: the job was not very glamorous after the upheavals which had taken place in the editorial world following the political changes. Somebody in the Editorial Boards must have suggested Martin Stutzmann. I am sure that there was opposition: one usually looks for a well-established person ready to leave his direct involvement in science and take up a new endeavor of a more administrative nature. Nevertheless, the powers that be soon realized that Martin was an excellent, if somewhat unconventional candidate who had enough energy to remain a topnotch scientist and to lead the journal in the difficult times ahead: he was offered the job. In the negotiations that followed, he insisted in getting the administrative structures that would allow him to improve the battered quality of the journal and to continue his scientific productivity. Today we are happy to see that he succeeded in both endeavors. The journal has since grown in size and considerably improved its quality

  3. From the Editor-in-chief

    Directory of Open Access Journals (Sweden)

    Simeon Oka

    2010-01-01

    Full Text Available Special issue of the journal Thermal Science dedicated to Dubrovnik Conference on Sustainable Development become already traditional. Present issue, Vol. 14, No. 3, 2010, is the 4th one, and contains selected papers presented at the 5th Dubrovnik Conference on Sustainable Development of Energy, Water, and Environment Systems, held from September 30 to October 3, 2009, in Dubrovnik, Croatia. 5th Dubrovnik Conference was held in the shadow of the new European Energy policy, formulated in short as: "a new energy-climate pack age of measures, reaching for obligatory targets of 20% renewable energy in gross consumption, 10% renewable fuels in transport, 20% decrease of greenhouse gases emissions, and 20% in crease of energy efficiency by 2020". Considering this fact, selection of the papers for this issue has the aim to show the reflection of this process on the energy policy and practice in the countries of the South East European region (SEE region. Selection of papers presented at the 5th Dubrovnik Conference, done by Guest editors, clearly shows that countries of the SEE region, depending on specific energy and economic conditions, made great efforts to follow recommendations of the new European energy policy, and to meet challenges of climate changes, and at the same time to in crease security of energy supply. I am deeply grateful to the Guest editors, Professors Neven Duić, Zvonimir Guzović, and Daniel R. Schneider, for excellent paper selection, the job which is at the same time highly professional and delicate. I am sure, that readers will obtain realistic insight in the policies, activities, achievements, results, and barriers, existing in most of the countries in the South East European region, along their movement towards sustainable development. Having in mind in creased interest in research and engineering activities aimed to "improvement and dissemination of knowledge on methods, policies, and technologies for increasing the

  4. Herlyn Werner Wunderlich Syndrome with Hematocolpos: An Unusual Case Report of Full Diagnostic Approach and Treatment

    Directory of Open Access Journals (Sweden)

    Rohit Bhoil

    2016-05-01

    Full Text Available Herlyn-Werner-Wunderlich (HWW syndrome is an uncommon combined müllerian duct anomalies (MDAs and mesonephric duct malformation of female urogenital tract characterized by uterus didelphys and obstructed hemi-vagina and ipsilateral renal agenesis (OHVIRA syndrome. We present a rare and unusual case of this syndrome in a 19 year-old female who suffered from hypomenorrhoea and abdominal pain. She had an obstructed hemi-vagina on right side which led to marked distention of ipsilateral cervix, while proximal hemi-vagina compressed the contralateral side causing its partial obstruction resulting in hypomenorrhoea. Understanding the imaging findings of this rare condition is important for early diagnosis in order to prevent complications which may lead to infertility.

  5. Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome

    Science.gov (United States)

    Heyn, Holger; Moran, Sebastian; Esteller, Manel

    2013-01-01

    DNA methylation gradiently changes with age and is likely to be involved in aging-related processes with subsequent phenotype changes and increased susceptibility to certain diseases. The Hutchinson-Gilford Progeria (HGP) and Werner Syndrome (WS) are two premature aging diseases showing features of common natural aging early in life. Mutations in the LMNA and WRN genes were associated to disease onset; however, for a subset of patients the underlying causative mechanisms remain elusive. We aimed to evaluate the role of epigenetic alteration on premature aging diseases by performing comprehensive DNA methylation profiling of HGP and WS patients. We observed profound changes in the DNA methylation landscapes of WRN and LMNA mutant patients, which were narrowed down to a set of aging related genes and processes. Although of low overall variance, non-mutant patients revealed differential DNA methylation at distinct loci. Hence, we propose DNA methylation to have an impact on premature aging diseases. PMID:23257959

  6. Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome.

    Science.gov (United States)

    Heyn, Holger; Moran, Sebastian; Esteller, Manel

    2013-01-01

    DNA methylation gradiently changes with age and is likely to be involved in aging-related processes with subsequent phenotype changes and increased susceptibility to certain diseases. The Hutchinson-Gilford Progeria (HGP) and Werner Syndrome (WS) are two premature aging diseases showing features of common natural aging early in life. Mutations in the LMNA and WRN genes were associated to disease onset; however, for a subset of patients the underlying causative mechanisms remain elusive. We aimed to evaluate the role of epigenetic alteration on premature aging diseases by performing comprehensive DNA methylation profiling of HGP and WS patients. We observed profound changes in the DNA methylation landscapes of WRN and LMNA mutant patients, which were narrowed down to a set of aging related genes and processes. Although of low overall variance, non-mutant patients revealed differential DNA methylation at distinct loci. Hence, we propose DNA methylation to have an impact on premature aging diseases.

  7. Un'estrema solitudine la vita e l'opera di Werner Heisenberg

    CERN Document Server

    Cassidy, David C

    1996-01-01

    Il genio di Werner Heisenberg attraversa l'orizzonte della fisica del nostro secolo come una meteora. Testimoniano della fecondità e dell'originalità del suo pensiero non solo il Nobel che gli fu assegnato a soli 32 anni, ma soprattutto i decisivi impulsi da lui dati alla fisica quantistica, alla teoria delle particelle elementari, alla teoria del nucleo. Si deve a Heisenberg quel "principio di indeterminazione" che ha rivoluzionato non solo il corso della fisica ma il modo di concepire la posizione dell'uomo nell'universo. L'interesse del libro, però, vuole andare oltre la fisica, giacché il curriculum del "ragazzo di campagna dei biondi capelli" rispecchia in forma emblematica l'ambiguo rapporto della scienza col potere.

  8. Robustness measure of hybrid intra-particle entanglement, discord, and classical correlation with initial Werner state

    Science.gov (United States)

    Saha, P.; Sarkar, D.

    2016-02-01

    Quantum information processing is largely dependent on the robustness of non-classical correlations, such as entanglement and quantum discord. However, all the realistic quantum systems are thermodynamically open and lose their coherence with time through environmental interaction. The time evolution of quantum entanglement, discord, and the respective classical correlation for a single, spin-1/2 particle under spin and energy degrees of freedom, with an initial Werner state, has been investigated in the present study. The present intra-particle system is considered to be easier to produce than its inter-particle counterpart. Experimentally, this type of system may be realized in the well-known Penning trap. The most stable correlation was identified through maximization of a system-specific global objective function. Quantum discord was found to be the most stable, followed by the classical correlation. Moreover, all the correlations were observed to attain highest robustness under initial Bell state, with minimum possible dephasing and decoherence parameters.

  9. Werner syndrome: a changing pattern of clinical manifestations in Japan (1917~2008).

    Science.gov (United States)

    Goto, M; Ishikawa, Y; Sugimoto, M; Furuichi, Y

    2013-02-01

    As ~75% of the Werner syndrome (WS) patients recognized between 1904 and 2008 all over the world are of Japanese origin, the most case reports and clinical studies on WS has been published in Japanese journals. Thus, the detailed English-written clinical review on the recent WS case reports has been warranted. Although WS has been characterized by a variety of clinical manifestations mimicking premature aging, the recent longevity and delayed age-associated manifestations observed both from Japanese WS and general population may suggest a common environmental effect on some gene(s) other than WRN and may give us a newer pathophysiological look at WS and also natural aging through the molecular dysfunction of WRN.

  10. High-Redshift Star Formation in a Time-Dependent Lyman-Werner Background

    CERN Document Server

    Visbal, Eli; Terrazas, Bryan; Bryan, Greg L; Barkana, Rennan

    2014-01-01

    The first generation of stars produces a background of Lyman-Werner (LW) radiation which can photo-dissociate molecular hydrogen, increasing the mass of dark matter halos required to host star formation. Previous studies have determined the critical mass required for efficient molecular cooling with a constant LW background. However, the true background is expected to increase rapidly at early times. Neglecting this evolution could underestimate star formation in small halos that may have started to cool in the past when the LW intensity was much lower. Background evolution is a large source of uncertainty in pre-reionization predictions of the cosmological 21cm signal, which can be observed with future radio telescopes. To address this, we perform zero-dimentional one-zone calculations that follow the density, chemical abundances, and temperature of gas in the central regions of dark matter halos, including hierarchical growth and an evolving LW background. We begin by studying the physics of halos subjected...

  11. Genetics and aging; the Werner syndrome as a segmental progeroid syndrome.

    Science.gov (United States)

    Martin, G M

    1985-01-01

    The maximum lifespan potential is a constitutional feature of speciation and must be subject to polygenic controls acting both in the domain of development and in the domain of the maintenance of macromolecular integrity. The enormous genetic heterogeneity that characterizes our own species, the complexities of numerous nature-nurture interactions, and the quantitative and qualitative variations of the senescent phenotype that are observed suggest that precise patterns of aging in each of us may be unique. Patterns of aging may also differ sharply among species (for example, semelparous vs. multiparous mammals). Some potential common denominators, however, allow one to identify progeroid syndromes in man that could lead to the elucidation of important pathways of gene action. (The suffix "-oid" means "like"; it does not mean identity.) Unimodal progeroid syndromes (eg., familial dementia of the Alzheimer type, an autosomal dominant) can help us understand the pathogenesis of a particular aspect of the senescent phenotype of man. Segmental progeroid syndromes (eg. the Werner syndrome, an autosomal recessive) may be relevant to multiple aspects of the senescent phenotype. Some results of research on the Werner syndrome may be interpreted as support for "peripheral" as opposed to "central" theories of aging; they are consistent with the view that gene action in the domain of development (adolescence, in this instance) can set the stage for patterns of aging in the adult; they point to the importance of mesenchymal cell populations in the pathogenesis of age-related disorders; finally, they underscore the role of chromosomal instability, especially in the pathogenesis of neoplasia.

  12. Prematurely aged children: molecular alterations leading to Hutchinson-Gilford progeria and Werner syndromes.

    Science.gov (United States)

    Domínguez-Gerpe, Lourdes; Araújo-Vilar, David

    2008-12-01

    Ageing is thought to be a polygenic and stochastic process in which multiple mechanisms operate at the same time. At the level of the individual organism ageing is associated with a progressive deterioration of health and quality of life, sharing common features such as: alopecia and grey hair, loss of audition, macular degeneration, neurodegeneration, cardiovascular diseases, osteoporosis, cataract formation, type-2 diabetes, lipodystrophies; a generally increased susceptibility to infection, autoimmune disorders and diseases such as cancer; and an impaired ability to cope with stress. Recent studies of mechanisms involved in the ageing process are contributing to the identification of genes involved in longevity. Monogenic heritable disorders causing premature ageing, and animal models have contributed to the understanding of some of the characteristic organism-level features associated with human ageing. Werner syndrome and Hutchinson-Gilford progeria syndrome are the best characterized human disorders. Werner syndrome patients have a median life expectancy of 47 years with clinical conditions from the second decade of life. Hutchinson-Gilford progeria syndrome patients die at a median age of 11-13 years with clinical conditions appearing soon after birth. In both syndromes, alterations in specific genes have been identified, with mutations in the WRN and LMNA genes respectively being the most closely associated with each syndrome. Results from molecular studies strongly suggest an increase in DNA damage and cell senescence as the underlying mechanism of pathological premature ageing in these two human syndromes. The same general mechanism has also been observed in human cells undergoing the normal ageing process. In the present article the molecular mechanisms currently proposed for explaining these two syndromes, which may also partly explain the normal ageing process, are reviewed.

  13. The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation.

    Directory of Open Access Journals (Sweden)

    Patricia L Opresko

    Full Text Available RecQ DNA helicases are critical for preserving genome integrity. Of the five RecQ family members identified in humans, only the Werner syndrome protein (WRN possesses exonuclease activity. Loss of WRN causes the progeroid disorder Werner syndrome which is marked by cancer predisposition. Cellular evidence indicates that WRN disrupts potentially deleterious intermediates in homologous recombination (HR that arise in genomic and telomeric regions during DNA replication and repair. Precisely how the WRN biochemical activities process these structures is unknown, especially since the DNA unwinding activity is poorly processive. We generated biologically relevant mobile D-loops which mimic the initial DNA strand invasion step in HR to investigate whether WRN biochemical activities can disrupt this joint molecule. We show that WRN helicase alone can promote branch migration through an 84 base pair duplex region to completely displace the invading strand from the D-loop. However, substrate processing is altered in the presence of the WRN exonuclease activity which degrades the invading strand both prior to and after release from the D-loop. Furthermore, telomeric D-loops are more refractory to disruption by WRN, which has implications for tighter regulation of D-loop processing at telomeres. Finally, we show that WRN can recognize and initiate branch migration from both the 5' and 3' ends of the invading strand in the D-loops. These findings led us to propose a novel model for WRN D-loop disruption. Our biochemical results offer an explanation for the cellular studies that indicate both WRN activities function in processing HR intermediates.

  14. Team of three JGR-Space Physics editors appointed

    Science.gov (United States)

    Three editors from the United States, Europe, and Asia have been appointed to lead JGR-Space Physics into the new millennium. This new team will recognize and foster the substantial contributions that scientists from the international community make to the journal. Janet Luhmann, a Senior Fellow at the Space Sciences Laboratory, University of California, Berkeley, will serve as Senior Editor. Luhmann will play a coordinating role for the regional editors, which will be especially important as the Union moves into electronic publishing and adopts new ways of using the technology to publish research findings.

  15. EDITORIAL: Incoming Editor-in-Chief

    Science.gov (United States)

    Webb, Steve

    2006-01-01

    Physics in Medicine and Biology (PMB) is a journal that originated in the UK but is now rightly regarded as one of the pre-eminent international journals for the publication of material coming within its remit. It is 50 years old and its maturity is an outcome of the consistent support of high performing authors, a supportive and professional publishing house, dedicated referees, many vigorous and conscientious editorial boards and the collective input of the 10 previous Editors as listed in his incoming editorial (January 2000 issue) by the retiring Editor, Professor Alun Beddoe. The scientific climate and it associated publication modus operandi in the 1950s was very different from that at the current time and the journal has evolved to reflect this. Hence today the scope of content is somewhat broader, the size of the journal is vastly greater, the whole publication process is slicker and more efficient and a paper in PMB is highly prized by its authors and those who look to quality factors and impact. The quality of the journal still relies on the voluntary labour and expertise of its busy international referees and Board members. For many years I have tried to place my own research material in PMB and encourage my teams to do likewise, not only acknowledging the prestige of the journal but also because of the extraordinarily fast turnaround time of all the processes without any loss of quality. This serves us very well and the publishing team are to be congratulated. Some things seem to change more slowly or not at all, however. The prediction, when I started my research career, that books and journals would be dinosaurs by now has manifestly not come true and, whilst most of us are addicted (and why not?) to the electronic ways of doing things that can be done by more traditional ways, PMB and a packet of reprints from time to time arriving by post still has a reassuring feel despite the fact that the papers have been `on-line' for a while before. An incoming

  16. Data Sharing: a New Editorial Initiative from the International Committee of Medical Journal Editors. Implications for the Editors' Network.

    Science.gov (United States)

    Alfonso, Fernando

    2017-05-01

    The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship-emphasizing the importance of responsibility and accountability-, have been proposed. This year a new editorial initiative to foster sharing of clinical trial data has been launched. This review discusses this novel initiative with the aim of increasing awareness among readers, investigators, authors and Editors of the Editors' Network of the European Society of Cardiology.

  17. Data Sharing: A New Editorial Initiative of the International Committee of Medical Journal Editors. Implications for the Editors' Network.

    Science.gov (United States)

    Alfonso, Fernando; Adamyan, Karlen; Artigou, Jean-Yves; Aschermann, Michael; Boehm, Michael; Buendia, Alfonso; Chu, Pao-Hsien; Cohen, Ariel; Dei Cas, Livio; Dilic, Mirza; Doubell, Anton; Echeverri, Dario; Enç, Nuray; Ferreira-González, Ignacio; Filipiak, Krzysztof J; Flammer, Andreas; Fleck, Eckart; Gatzov, Plamen; Ginghina, Carmen; Goncalves, Lino; Haouala, Habib; Hassanein, Mahmoud; Heusch, Gerd; Huber, Kurt; Hulín, Ivan; Ivanusa, Mario; Krittayaphong, Rungroj; Lau, Chu-Pak; Marinskis, Germanas; Mach, François; Moreira, Luiz Felipe; Nieminen, Tuomo; Oukerraj, Latifa; Perings, Stefan; Pierard, Luc; Potpara, Tatjana; Reyes-Caorsi, Walter; Rim, Se-Joong; Rødevand, Olaf; Saade, Georges; Sander, Mikael; Shlyakhto, Evgeny; Timuralp, Bilgin; Tousoulis, Dimitris; Ural, Dilek; Piek, J J; Varga, Albert; Lüscher, Thomas F

    2017-01-01

    The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship - emphasizing the importance of responsibility and accountability - have been proposed. Last year, a new editorial initiative to foster sharing of clinical trial data was launched. This review discusses this novel initiative with the aim of increasing awareness among readers, investigators, authors and editors belonging to the Editors' Network of the European Society of Cardiology.

  18. Data sharing: A new editorial initiative of the International Committee of Medical Journal Editors : Implications for the Editors' Network.

    Science.gov (United States)

    Alfonso, F

    2017-05-01

    The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship - emphasising the importance of responsibility and accountability - have been proposed. Last year, a new editorial initiative to foster sharing of clinical trial data was launched. This review discusses this novel initiative with the aim of increasing awareness among readers, investigators, authors and editors belonging to the Editors' Network of the European Society of Cardiology.

  19. Archaeology in Latin America, by Gustavo G. Politis and Benjamin Alberti, editors, 1999, Routledge, London

    Directory of Open Access Journals (Sweden)

    David L. Browman

    2001-11-01

    Full Text Available The two editors argue in their preface to the volume that the particular sociopolitical context of Latin America has led to a regionalism not seen in North America or Europe, resulting in a unique variety of archaeology. They particularly conceive "Latin American archaeology" in this case to he only that archaeology done by individuals who are citizens of the countries of the region, and they ex­clude from consideration as being considered "Latin American archaeology" the work of foreign scholars such as North Americans and Europeans who do research in the region.

  20. Predicting Post-Editor Profiles from the Translation Process

    DEFF Research Database (Denmark)

    Singla, Karan; Orrego-Carmona, David; Gonzales, Ashleigh Rhea

    2014-01-01

    Translation Process Research Database (TPR-DB). The analysis has two main research goals: We create n-gram models based on user activity and part-of-speech sequences to automatically cluster post-editors, and we use discriminative classifier models to characterize post-editors based on a diverse range......The purpose of the current investigation is to predict post-editor profiles based on user behaviour and demographics using machine learning techniques to gain a better understanding of post-editor styles. Our study extracts process unit features from the CasMaCat LS14 database from the CRITT...... of translation process features. The classification and clustering of participants resulting from our study suggest this type of exploration could be used as a tool to develop new translation tool features or customization possibilities....

  1. The Editors' Role in Fighting Against Scientific Misconduct(Summary)

    Institute of Scientific and Technical Information of China (English)

    Dahong Zhuo

    2009-01-01

    @@ In the scientific publishing community of the world,there has been an increasing awareness of journal editors' responsibility for prevention and management of scientific misconduct and conflict of interest.

  2. Sobre o editor: notas para sua história

    Directory of Open Access Journals (Sweden)

    Anibal Bragança

    2005-12-01

    Full Text Available O artigo procura contribuir para a definição da função editor de livros impressos e oferece indicações básicas de sua história no Ocidente. Etimologia e conceitos.Tipologia histórica. Formação, desenvolvimento e crise da cultura impressa. Mudanças e novas oportunidades para a função editor na contemporaneidade.

  3. The WebACS - An Accessible Graphical Editor.

    Science.gov (United States)

    Parker, Stefan; Nussbaum, Gerhard; Pölzer, Stephan

    2017-01-01

    This paper is about the solution to accessibility problems met when implementing a graphical editor, a major challenge being the comprehension of the relationships between graphical components, which needs to be guaranteed for blind and vision impaired users. In the concrete case the HTML5 canvas and Javascript were used. Accessibility was reached by implementing a list view of elements, which also enhances the usability of the editor.

  4. Developing Visual Editors for High-Resolution Haptic Patterns

    DEFF Research Database (Denmark)

    Cuartielles, David; Göransson, Andreas; Olsson, Tony

    2012-01-01

    In this article we give an overview of our iterative work in developing visual editors for creating high resolution haptic patterns to be used in wearable, haptic feedback devices. During the past four years we have found the need to address the question of how to represent, construct and edit high...... resolution haptic patterns so that they translate naturally to the user’s haptic experience. To solve this question we have developed and tested several visual editors...

  5. Laboratory studies of UV emissions of H2 by electron impact - The Werner- and Lyman-band systems

    Science.gov (United States)

    Ajello, J. M.; Srivastava, S. K.; Yung, Y. L.

    1982-01-01

    The vacuum ultraviolet electron-impact-induced fluorescence emissions of H2 were studied for the Lyman and Werner band systems in the range of 120-170 nm, using an optical system containing a photomultiplier and a spectrometer, over an energy range from threshold to 400 eV. The emission cross sections for the Lyman and Werner transitions at 100 eV are determined. The cross-section ratio is in excellent agreement with theoretical calculations and experimental data for the optical oscillator strengths. The cross-section for cascading to the B state is stated as a percentage of the total emission cross section at both 100 and 300 eV, increasing substantially at 20 eV. The vibrational population distribution of the B state is found to be a function of electron-impact energy as the importance of cascading relative to direct excitation changes with electron-impact energy.

  6. El editor de mapas conceptuales DigiDocMap The editor of conceptual maps, DigiDocMap

    Directory of Open Access Journals (Sweden)

    Cristòfol Rovira Fontanals

    2007-06-01

    Full Text Available DigiDocMap es un editor freeware y open source para la creación de mapas conceptuales. Es el primer resultado de un proyecto de investigación orientado a la generación de herramientas para representar el conocimiento. Se han desarrollado tres versiones de este editor desde el año 2002. En el artículo se analizan las prestaciones de cada una de ellas y las razones que motivaron la incorporación de los principales cambios.DigiDocMap is freeware editor and open source for the creation of conceptual maps. It is the first product of a research project intended to generate tools for knowledge representation. Three versions of this editor have been created since 2002. The paper analyses each one of these and the reasons which motivated incorporation of the principal modifications.

  7. 降低成本 和Bosch Rexroth公司Werner Blaurock工程师的交谈

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    和消费领域一样,工业界也只想为它真正需要的技术付钱。这在今天意味着什么?Bosch Rexroth公司线性运动和装配技术部经理Werner Blaurock工程师就降低设计,生产和维修费用的问题谈了他的观点。

  8. A note on the paper "Minimizing total tardiness on parallel machines with preemptions" by Kravchenko and Werner [2010

    CERN Document Server

    Prot, D; Lahlou, C

    2011-01-01

    In this note, we point out two major errors in the paper "Minimizing total tardiness on parallel machines with preemptions" by Kravchenko and Werner [2010]. More precisely, they proved that both problems P|pmtn|sum(Tj) and P|rj, pj = p, pmtn|sum(Tj) are NP-Hard. We give a counter-example to their proofs, letting the complexity of these two problems open.

  9. Polymeric lithography editor: Editing lithographic errors with nanoporous polymeric probes.

    Science.gov (United States)

    Rajasekaran, Pradeep Ramiah; Zhou, Chuanhong; Dasari, Mallika; Voss, Kay-Obbe; Trautmann, Christina; Kohli, Punit

    2017-06-01

    A new lithographic editing system with an ability to erase and rectify errors in microscale with real-time optical feedback is demonstrated. The erasing probe is a conically shaped hydrogel (tip size, ca. 500 nm) template-synthesized from track-etched conical glass wafers. The "nanosponge" hydrogel probe "erases" patterns by hydrating and absorbing molecules into a porous hydrogel matrix via diffusion analogous to a wet sponge. The presence of an interfacial liquid water layer between the hydrogel tip and the substrate during erasing enables frictionless, uninterrupted translation of the eraser on the substrate. The erasing capacity of the hydrogel is extremely high because of the large free volume of the hydrogel matrix. The fast frictionless translocation and interfacial hydration resulted in an extremely high erasing rate (~785 μm(2)/s), which is two to three orders of magnitude higher in comparison with the atomic force microscopy-based erasing (~0.1 μm(2)/s) experiments. The high precision and accuracy of the polymeric lithography editor (PLE) system stemmed from coupling piezoelectric actuators to an inverted optical microscope. Subsequently after erasing the patterns using agarose erasers, a polydimethylsiloxane probe fabricated from the same conical track-etched template was used to precisely redeposit molecules of interest at the erased spots. PLE also provides a continuous optical feedback throughout the entire molecular editing process-writing, erasing, and rewriting. To demonstrate its potential in device fabrication, we used PLE to electrochemically erase metallic copper thin film, forming an interdigitated array of microelectrodes for the fabrication of a functional microphotodetector device. High-throughput dot and line erasing, writing with the conical "wet nanosponge," and continuous optical feedback make PLE complementary to the existing catalog of nanolithographic/microlithographic and three-dimensional printing techniques. This new PLE

  10. Sowing Black Hole Seeds: Forming Direct Collapse Black Holes With Realistic Lyman-Werner Radiation Fields in Cosmological Simulations

    Science.gov (United States)

    Holley-Bockelmann, Kelly; Dunn, Glenna; Bellovary, Jillian M.; Christensen, Charlotte

    2016-01-01

    Luminous quasars detected at redshifts z > 6 require that the first black holes form early and grow to ~109 solar masses within one Gyr. Our work uses cosmological simulations to study the formation and early growth of direct collapse black holes. In the pre-reionization epoch, molecular hydrogen (H2) causes gas to fragment and form Population III stars, but Lyman-Werner radiation can suppress H2 formation and allow gas to collapse directly into a massive black hole. The critical flux required to inhibit H2 formation, Jcrit, is hotly debated, largely due to the uncertainties in the source radiation spectrum, H2 self-shielding, and collisional dissociation rates. Here, we test the power of the direct collapse model in a non-uniform Lyman-Werner radiation field, using an updated version of the SPH+N-body tree code Gasoline with H2 non-equilibrium abundance tracking, H2 cooling, and a modern SPH implementation. We vary Jcrit from 30 to 104 J21 to study the effect on seed black holes, focusing on black hole formation as a function of environment, halo mass, metallicity, and proximity of the Lyman-Werner source. We discuss the constraints on massive black hole occupation fraction in the quasar epoch, and implications for reionization, high-redshift X-ray background radiation, and gravitational waves.

  11. Editor's Note%编者前言

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ Except for Zaoxia Cheng's paper which provides a systematic critique of the U.S.policies toward Tibet based on the author's archival research both in China and abroad,the articles and book reviews in this volume focus on the history of the Six dynasties,a sub-arca of the history of the Wei,Jin,and Northern and Southern dynasties.

  12. EDITORIAL: Incoming Editor-in-Chief Incoming Editor-in-Chief

    Science.gov (United States)

    Birch, David

    2012-01-01

    It is a pleasure and an honour for me to be taking over as Editor-in-Chief of Measurement Science and Technology. MST is well known across research communities worldwide as a leading journal in which to publish new techniques and instrumentation. It has gained this enviable position largely because of the excellent guidance of its Editorial Board and dedicated staff at Institute of Physics Publishing over many years. I want to highlight in particular the contribution of the outgoing Editor Peter Hauptmann, and other Editors before him, in making the journal truly international. We thank Peter immensely for all his hard work in leading the journal, having exceptionally served two terms, each of five years. I come into the post of Editor at a very interesting and challenging time for research. The global recession is leading to cuts in research funding in many countries, researchers and their outputs are coming under closer scrutiny than ever before, and more is being expected of them. Journals play a critical role in monitoring and maintaining research standards, but we should be careful not to assume that journal Impact Factor is the sole measure of research quality. Although expediency may sometimes demand it, Impact Factor, as practitioners know, is subject dependent. One of the great things about science and technology for me is its level playing field. The key point is still innovation no matter where the work is done or where it is published. MST has a long pedigree of being the natural home of the highest quality papers from leading researchers wishing to report novel instrumentation and techniques. 2013 will mark the 90th anniversary of MST and we look forward to celebrating in style its sustained success. I recall with pride the first paper I published in Journal of Physics E: Scientific Instruments (as MST was previously titled) back in 1977. The paper reported the design and application of an early fluorescence lifetime spectrometer that I had constructed

  13. Editors View the Continuous Publication Model as a Satisfactory Alternative for Open Access LIS Journals

    Directory of Open Access Journals (Sweden)

    Richard Hayman

    2014-09-01

    Full Text Available A Review of: Cirasella, J., & Bowdoin, S. (2013. Just roll with it? Rolling volumes vs. discrete issues in open access library and information science journals. Journal of Librarianship and Scholarly Communication, 1(4. http://dx.doi.org/10.7710/2162-3309.1086 Abstract Objective – To understand the prevalence of, motivations for, and satisfaction with using a rolling-volume publishing model, as opposed to publishing discrete issues, across open access academic journals in library and information science. Design – A 12 question survey questionnaire. Setting – English-language, open access library and information science (LIS journals published in the United States of America. Subjects – A total of 21 open access LIS journals identified via the Directory of Open Access Journals that were actively publishing, and that also met the authors’ standard of scholarliness, which they established by identifying a journal’s peer-review process or other evidence of rigorous review. Based on responses, 12 journals published using discrete issues, while 9 published as rolling volumes or as rolling volumes with some discrete issues. Methods – In late 2011, the study’s authors invited lead editors or primary journal contacts to complete the survey. Survey participants were asked to identify whether their journal published in discrete issues, rolling volumes, or rolling volumes with occasional discrete issues, with the latter two categories combined as one for ease of results analysis. Survey logic split respondents into two groups, either discrete-issue or rolling-volume. Respondents in both categories were posed similar sets of questions, with the key difference being that the questions directed at each category accounted for the publication model the journals themselves identified as using. Editors from both groups were asked about the reasons for using the publication model they identified for their journal: within the survey tool, authors

  14. Inflammageing assessed by MMP9 in normal Japanese individuals and the patients with Werner syndrome.

    Science.gov (United States)

    Goto, Makoto; Chiba, Junji; Matsuura, Masaaki; Iwaki-Egawa, Sachiko; Watanabe, Yasuhiro

    2016-05-01

    Age-associated minor inflammation: inflammageing may explain human ageing mechanism(s). Our previous study reported a significant increase in the serum level of highly sensitive C-reactive protein (hsCRP) with normal ageing and the patients with Werner syndrome (WS). To further study the minor inflammatory condition associated with ageing, another possible ageing biomarker: matrix metalloproteinase-9 (MMP9) was examined in the sera from 217 normal Japanese individuals aged between 1 and 100 years and 41 mutation-proven Japanese WS aged between 32 and 70 years. MMP9 was assayed by ELISA. The serum level of MMP9 was elevated significantly (p normal ageing from both sexes as hsCRP. In contrast to normal ageing, the serum MMP9 level in WS decreased significantly with calendar age (p normal adult population aged between 25 and 70 years (109.1 ± 9.4), nor normal elderly population aged between 71 and 100 years (179.9 ± 16.1). Although both normal ageing and WS were associated with minor inflammation, the inflammatory parameters such as serum MMP9 and hsCRP changed differently between normal ageing and WS. The WS-specific chronic inflammation including skin ulcer and diabetes mellitus may contribute the different behavior of both ageing biomarkers from normal ageing.

  15. Star Formation in the First Galaxies I: Collapse Delayed by Lyman-Werner Radiation

    CERN Document Server

    Safranek-Shrader, Chalence; Federrath, Christoph; Dubey, Anshu; Milosavljevic, Milos; Bromm, Volker

    2012-01-01

    We investigate the process of metal-free star formation in the first galaxies with a high-resolution cosmological simulation. We consider the cosmologically motivated scenario in which a strong molecule-destroying Lyman-Werner (LW) background inhibits effective cooling in low-mass haloes, delaying star formation until the collapse or more massive haloes. Only when molecular hydrogen (H2) can self-shield from LW radiation, which requires a halo capable of cooling by atomic line emission, will star formation be possible. To follow the formation of multiple gravitationally bound objects, at high gas densities we introduce sink particles which accrete gas directly from the computational grid. We find that in a 1 Mpc^3 (comoving) box, runaway collapse first occurs in a 3x10^7 M_sun dark matter halo at z~12 assuming a background intensity of J21=100. Due to a runaway increase in the H2 abundance and cooling rate, a self-shielding, supersonically turbulent core develops abruptly with ~10^4 M_sun in cold gas availabl...

  16. Scoliosis in Herlyn-Werner-Wunderlich syndrome: a case report and literature review.

    Science.gov (United States)

    Li, Zheng; Yu, Xin; Shen, Jianxiong; Liang, Jinqian

    2014-12-01

    Herlyn-Werner-Wunderlich syndrome (HWWS) is a congenital Müllerian duct anomaly characterized by uterine didelphys, obstructed hemivagina, and ipsilateral renal agenesis. Little is reported about spinal deformity associated with this syndrome. This study presents a case of scoliosis occurring in the setting of HWWS and explores the possible association between the 2 diseases. A previously unreported scoliosis in HWWS is described. The patient is a 12-year-old Chinese female with scoliosis that underwent a posterior correction at thoracic 5-thoracic 12 (T5-T12) levels, using the Moss-SI (Johnson & Johnson, American) spinal system. At 24-month follow-up, the patient was clinically pain free and well balanced. Plain radiographs showed solid spine fusion with no loss of deformity correction. Six months after scoliosis correction surgery, the patient went to our clinics for the treatment of HWWS. She was performed a vaginal septum resection and detected with pyocolpos. Her follow-up was symptom free at the fourth postoperative month. The prevalence of scoliosis among patients with HWWS was 8.57% that is much higher than the incidence of congential scoliosis among general population (1/1000). To the best of our knowledge, this is the first report of HWWS with thoracic scoliosis. During surgery, surgeons and anesthesiologists must pay particular attention to the Müllerian duct anomaly and renal agenesis associated with HWWS. There is a potential association between congenital scoliosis and HWWS.

  17. Epigenetic Regulation of Werner Syndrome Gene in Age-Related Cataract

    Directory of Open Access Journals (Sweden)

    Xi Zhu

    2015-01-01

    Full Text Available Purpose. To examine the promoter methylation and histone modification of WRN (Werner syndrome gene, a DNA repair gene, and their relationship with the gene expression in age-related cataract (ARC lens. Methods. We collected the lenses after cataract surgery from 117ARC patients and 39 age-matched non-ARC. WRN expression, DNA methylation and histone modification around the CpG island were assessed. The methylation status of Human-lens-epithelium cell (HLEB-3 was chemically altered to observe the relationship between methylation and expression of WRN. Results. The WRN expression was significantly decreased in the ARC anterior lens capsules comparing with the control. The CpG island of WRN promoter in the ARC anterior lens capsules displayed hypermethylation comparing with the controls. The WRN promoter was almost fully methylated in the cortex of ARC and control lens. Acetylated H3 was lower while methylated H3-K9 was higher in ARC anterior lens capsules than that of the controls. The expression of WRN in HLEB-3 increased after demethylation of the cells. Conclusions. A hypermethylation in WRN promoter and altered histone modification in anterior lens capsules might contribute to the ARC mechanism. The data suggest an association of altered DNA repair capability in lens with ARC pathogenesis.

  18. WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome.

    Science.gov (United States)

    Sadahira, Yoshito; Sugihara, Takashi; Fujiwara, Hideyo; Nishimura, Hirotake; Suetsugu, Yoshimasa; Takeshita, Morishige; Okamura, Seiichi; Goto, Makoto

    2015-03-01

    Genetic testing for mutations in the WRN gene is critical for the diagnosis of Werner syndrome (WS); however, these tests cannot be performed in a clinical setting. Nearly all of the WRN mutations result in expression of truncated WRN proteins that are missing the C-terminal nuclear localization signal. We evaluated the use of WRN protein immunohistochemistry for diagnosing WS using paraffin-embedded bone marrow sections. Using a well-defined commercially available polyclonal antibody against the C terminus of WRN, we found that of all the cell types tested, bone marrow erythroid precursors showed the strongest nuclear expression of WRN. Immunohistochemical analysis of bone marrow samples from 120 patients with non-WS hematological disorders (age range, 7 days-90 years) revealed WRN staining of the nuclei of CD71-positive early and late erythroid precursors. Erythroblasts negative for WRN immunostaining were only observed in two patients, both of whom were diagnosed with WS: one with concomitant myelodysplastic syndrome and the other with erythroleukemia with overexpression of TP53. Western blot analysis and immunocytochemistry indicated WRN was localized in the nuclei of the four positive control cell lines from non-WS patients but not in the five cell lines from WS patients, who had three different types of WRN mutations. Thus, immunohistochemical detection of WRN in erythroblasts from bone marrow paraffin sections could be useful in screening of WS cases and worthy of further molecular confirmation.

  19. Fluctuations in the High-Redshift Lyman-Werner and Lyman-alpha Radiation Backgrounds

    CERN Document Server

    Holzbauer, Lauren N

    2011-01-01

    We use a new method to model fluctuations of the Lyman-Werner (LW) and Lyman-alpha radiation backgrounds at high redshift. At these early epochs the backgrounds are symptoms of a universe newly lit with its first stars. LW photons (11.5-13.6 eV) are of particular interest because they dissociate molecular hydrogen, the primary coolant in the first minihalos. By using a variation of the halo model, we efficiently generate power spectra for any choice of radiation background. We find that the LW power spectrum typically traces the matter power spectrum at large scales but turns over at the scale corresponding to the effective `horizon' of LW photons (~100 comoving Mpc), unless the sources are extremely rare. The series of horizons that characterize the Lyman-alpha flux profile shape the fluctuations of that background in a similar fashion, though those imprints are washed out once one considers fluctuations in the brightness temperature of the 21-cm signal. The Lyman-alpha background strongly affects the redshi...

  20. Evaluating the Role of p38 MAPK in the Accelerated Cell Senescence of Werner Syndrome Fibroblasts

    Directory of Open Access Journals (Sweden)

    Terence Davis

    2016-04-01

    Full Text Available Progeroid syndromes show features of accelerated ageing and are used as models for human ageing, of which Werner syndrome (WS is one of the most widely studied. WS fibroblasts show accelerated senescence that may result from p38 MAP kinase activation since it is prevented by the p38 inhibitor SB203580. Thus, small molecule inhibition of p38-signalling may be a therapeutic strategy for WS. To develop this approach issues such as the in vivo toxicity and kinase selectivity of existing p38 inhibitors need to be addressed, so as to strengthen the evidence that p38 itself plays a critical role in mediating the effect of SB203580, and to find an inhibitor suitable for in vivo use. In this work we used a panel of different p38 inhibitors selected for: (1 having been used successfully in vivo in either animal models or human clinical trials; (2 different modes of binding to p38; and (3 different off-target kinase specificity profiles, in order to critically address the role of p38 in the premature senescence seen in WS cells. Our findings confirmed the involvement of p38 in accelerated cell senescence and identified p38 inhibitors suitable for in vivo use in WS, with BIRB 796 the most effective.

  1. Ethnic differences in thermoregulatory responses during resting, passive and active heating: application of Werner's adaptation model.

    Science.gov (United States)

    Lee, Joo-Young; Wakabayashi, Hitoshi; Wijayanto, Titis; Hashiguchi, Nobuko; Saat, Mohamed; Tochihara, Yutaka

    2011-12-01

    For the coherent understanding of heat acclimatization in tropical natives, we compared ethnic differences between tropical and temperate natives during resting, passive and active heating conditions. Experimental protocols included: (1) a resting condition (an air temperature of 28°C with 50% RH), (2) a passive heating condition (28°C with 50% RH; leg immersion in a hot tub at a water temperature of 42°C), and (3) an active heating condition (32°C with 70% RH; a bicycle exercise). Morphologically and physically matched tropical natives (ten Malaysian males, MY) and temperate natives (ten Japanese males, JP) participated in all three trials. The results saw that: tropical natives had a higher resting rectal temperature and lower hand and foot temperatures at rest, smaller rise of rectal temperature and greater temperature rise in bodily extremities, and a lower sensation of thirst during passive and active heating than the matched temperate natives. It is suggested that tropical natives' homeostasis during heating is effectively controlled with the improved stability in internal body temperature and the increased capability of vascular circulation in extremities, with a lower thirst sensation. The enhanced stability of internal body temperature and the extended thermoregulatory capability of vascular circulation in the extremities of tropical natives can be interpreted as an interactive change to accomplish a thermal dynamic equilibrium in hot environments. These heat adaptive traits were explained by Wilder's law of initial value and Werner's process and controller adaptation model.

  2. Telomerase Protects Werner Syndrome Lineage-Specific Stem Cells from Premature Aging

    Directory of Open Access Journals (Sweden)

    Hoi-Hung Cheung

    2014-04-01

    Full Text Available Werner syndrome (WS patients exhibit premature aging predominantly in mesenchyme-derived tissues, but not in neural lineages, a consequence of telomere dysfunction and accelerated senescence. The cause of this lineage-specific aging remains unknown. Here, we document that reprogramming of WS fibroblasts to pluripotency elongated telomere length and prevented telomere dysfunction. To obtain mechanistic insight into the origin of tissue-specific aging, we differentiated iPSCs to mesenchymal stem cells (MSCs and neural stem/progenitor cells (NPCs. We observed recurrence of premature senescence associated with accelerated telomere attrition and defective synthesis of the lagging strand telomeres in MSCs, but not in NPCs. We postulate this “aging” discrepancy is regulated by telomerase. Expression of hTERT or p53 knockdown ameliorated the accelerated aging phenotypein MSC, whereas inhibition of telomerase sensitized NPCs to DNA damage. Our findings unveil a role for telomerase in the protection of accelerated aging in a specific lineage of stem cells.

  3. DNA damage accumulation and TRF2 degradation in atypical Werner syndrome fibroblasts with LMNA mutations.

    Science.gov (United States)

    Saha, Bidisha; Zitnik, Galynn; Johnson, Simon; Nguyen, Quyen; Risques, Rosa A; Martin, George M; Oshima, Junko

    2013-01-01

    Segmental progeroid syndromes are groups of disorders with multiple features suggestive of accelerated aging. One subset of adult-onset progeroid syndromes, referred to as atypical Werner syndrome, is caused by mutations in the LMNA gene, which encodes a class of nuclear intermediate filaments, lamin A/C. We previously described rapid telomere attrition and accelerated replicative senescence in cultured fibroblasts overexpressing mutant lamin A. In this study, we investigated the cellular phenotypes associated with accelerated telomere shortening in LMNA mutant primary fibroblasts. In early passage primary fibroblasts with R133L or L140R LMNA mutations, shelterin protein components were already reduced while cells still retained telomere lengths comparable to those of controls. There was a significant inverse correlation between the degree of abnormal nuclear morphology and the level of TRF2, a shelterin subunit, suggesting a potential causal relationship. Stabilization of the telomeres via the introduction of the catalytic subunit of human telomerase, hTERT (human telomerase reverse transcriptase), did not prevent degradation of shelterin components, indicating that reduced TRF2 in LMNA mutants is not mediated by short telomeres. Interestingly, γ-H2AX foci (reflecting double strand DNA damage) in early passage LMNA mutant primary fibroblasts and LMNA mutant hTERT fibroblasts were markedly increased in non-telomeric regions of DNA. Our results raise the possibility that mutant lamin A/C causes global genomic instability with accumulation of non-telomeric DNA damage as an early event, followed by TRF2 degradation and telomere shortening.

  4. IJIMAI Editor's Note - Vol. 4 Issue 5

    Directory of Open Access Journals (Sweden)

    Jose Luis Cebrian Carretero

    2017-08-01

    Full Text Available Although Medicine has always been considered a Health Science, today it is not possible to obviate its relationship with other disciplines as Humanities and Basic Sciences. Doctors from everywhere and everyday work with the most sophisticated technology are trying to make their profession more accurate and precise, taking in consideration, at the same time, the human part of their daily labour. In this volume of the Journal, we will try to explore the relation between different medical specialities, basic science and engineering. In fact, modern Medicine requires the participation of these professionals who are involved with doctors in multidisciplinary teams. In this sense, Medical Engineering, is a new degree that is offered in a vast number of Universities along the world. This relationship between Medicine and Sciences can be found in any medical speciality so that, our aim in this volume, is to show different examples of doctors working together with other scientifics in any area of Medical sciences.The volume consists on twelve papers. Each paper explores a particular area of this multidisciplinary approach.

  5. From the Editor-in-Chief

    Directory of Open Access Journals (Sweden)

    Simeon Oka

    2011-01-01

    science. Included herein is a collection of original refereed research papers by well-established researchers in the field of nonlinear science. We hope that these papers will prove to be a timely and valuable reference for researchers in this area. Analytical approach to thermal science is challenging and promising, and is playing an even more important role in optimal design of various thermal problems. Considering this fact, selection of the papers for this special issue has the aim to show illustrating approaches to various thermal problems by various methods including fractal geometry and fractional calculus, and the present special issue can be used as paradigms for many other applications. I am deeply grateful to the Guest editors, Professor Ji-Huan He (now with National Engineering Laboratory of Modern Silk, Soochow University, Suzhow, China and Professor Lianchun Zheng (Department of Mathematics and Mechanics, University of Science and Technology Beijing, Beijing, China, for excellent paper selection, the job which is at the same time highly professional and delicate. I am sure, that readers will obtain realistic insight in how to apply the methods presented in this special issue to various problems.

  6. Core competencies for scientific editors of biomedical journals: consensus statement.

    Science.gov (United States)

    Moher, David; Galipeau, James; Alam, Sabina; Barbour, Virginia; Bartolomeos, Kidist; Baskin, Patricia; Bell-Syer, Sally; Cobey, Kelly D; Chan, Leighton; Clark, Jocalyn; Deeks, Jonathan; Flanagin, Annette; Garner, Paul; Glenny, Anne-Marie; Groves, Trish; Gurusamy, Kurinchi; Habibzadeh, Farrokh; Jewell-Thomas, Stefanie; Kelsall, Diane; Lapeña, José Florencio; MacLehose, Harriet; Marusic, Ana; McKenzie, Joanne E; Shah, Jay; Shamseer, Larissa; Straus, Sharon; Tugwell, Peter; Wager, Elizabeth; Winker, Margaret; Zhaori, Getu

    2017-09-11

    Scientific editors are responsible for deciding which articles to publish in their journals. However, we have not found documentation of their required knowledge, skills, and characteristics, or the existence of any formal core competencies for this role. We describe the development of a minimum set of core competencies for scientific editors of biomedical journals. The 14 key core competencies are divided into three major areas, and each competency has a list of associated elements or descriptions of more specific knowledge, skills, and characteristics that contribute to its fulfillment. We believe that these core competencies are a baseline of the knowledge, skills, and characteristics needed to perform competently the duties of a scientific editor at a biomedical journal.

  7. ‡biblios: An Open Source Cataloging Editor

    Directory of Open Access Journals (Sweden)

    Chris Catalfo

    2008-12-01

    Full Text Available ‡biblios is an open source cataloging editor designed to allow libraries to perform copy and original cataloging in a web based environment. ‡biblios allows users to search for, edit, and save bibliographic records in the MARC21/MARCXML formats. It also allows users to send records directly to integrated library systems such as the Koha ILS. Where most MARC editors are part of an integrated library system (and therefore require logging in, ‡biblios allows users to catalog with an open source standalone system available anywhere via a web browser. Unlike other cataloging editors, it offers an attractive user interface for searching, saving and editing cataloging records. This article describes the system architecture and design of ‡biblios.

  8. Developing Visual Editors for High-Resolution Haptic Patterns

    DEFF Research Database (Denmark)

    Cuartielles, David; Göransson, Andreas; Olsson, Tony;

    2012-01-01

    In this article we give an overview of our iterative work in developing visual editors for creating high resolution haptic patterns to be used in wearable, haptic feedback devices. During the past four years we have found the need to address the question of how to represent, construct and edit hi...... resolution haptic patterns so that they translate naturally to the user’s haptic experience. To solve this question we have developed and tested several visual editors......In this article we give an overview of our iterative work in developing visual editors for creating high resolution haptic patterns to be used in wearable, haptic feedback devices. During the past four years we have found the need to address the question of how to represent, construct and edit high...

  9. The color of complexes and UV-vis spectroscopy as an analytical tool of Alfred Werner's group at the University of Zurich.

    Science.gov (United States)

    Fox, Thomas; Berke, Heinz

    2014-01-01

    Two PhD theses (Alexander Gordienko, 1912; Johannes Angerstein, 1914) and a dissertation in partial fulfillment of a PhD thesis (H. S. French, Zurich, 1914) are reviewed that deal with hitherto unpublished UV-vis spectroscopy work of coordination compounds in the group of Alfred Werner. The method of measurement of UV-vis spectra at Alfred Werner's time is described in detail. Examples of spectra of complexes are given, which were partly interpreted in terms of structure (cis ↔ trans configuration, counting number of bands for structural relationships, and shift of general spectral features by consecutive replacement of ligands). A more complete interpretation of spectra was hampered at Alfred Werner's time by the lack of a light absorption theory and a correct theory of electron excitation, and the lack of a ligand field theory for coordination compounds. The experimentally difficult data acquisitions and the difficult spectral interpretations might have been reasons why this method did not experience a breakthrough in Alfred Werner's group to play a more prominent role as an important analytical method. Nevertheless the application of UV-vis spectroscopy on coordination compounds was unique and novel, and witnesses Alfred Werner's great aptitude and keenness to always try and go beyond conventional practice.

  10. Writing GNU Emacs Extensions Editor Customizations and Creations with Lisp

    CERN Document Server

    Glickstein, Bob

    2010-01-01

    Yes, it is possible to be all things to all people, if you're talking about the Emacs editor. As a user, you can make any kind of customization you want, from choosing the keystrokes that invoke your favorite commands to creating a whole new work environment that looks like nothing ever developed before. It's all in Emacs Lisp -- and in this short but fast-paced book. GNU Emacs is more than an editor; it's a programming environment, a communications package, and many other things. To provide such a broad range of functions, it offers a full version of the Lisp programming language

  11. EDITORIAL: New Editor-in-Chief for Nanotechnology New Editor-in-Chief for Nanotechnology

    Science.gov (United States)

    Couzin, Nina

    2009-01-01

    Nanotechnology is proud to announce the appointment of Professor Mark Reed, Yale University, as the new Editor-in-Chief from January 2009. Mark Reed holds the Harold Hodgkinson Chair of Engineering and Applied Science at Yale University. He has made significant contributions in the areas of quantum dots, electronic transport in nanoscale and mesoscopic systems, artificially structured materials and devices, and molecular electronics. Professor Reed has been associated with the journal as an Editorial Board member for a number of years and we are delighted that he has agreed to take on the scientific leadership of the journal in its 20th year. We also take the opportunity to thank Professor Mark Welland, Cambridge University, for his work as Editor-in-Chief since 2001, and for presiding over the re-launch and remarkable growth of the journal since then. Nanotechnology is unique in that it was the first peer-reviewed journal in the area of nanoscience, the first issue appearing in 1990. Since then it has established a distinguished publication record and has become a leading journal covering all aspects of nanoscale science and technology, as well as specializing in in-depth, comprehensive articles not seen in letter format journals. Published weekly and featuring subject sections, the journal is truly multidisciplinary in nature and is an excellent medium to quickly deliver your research results to readers worldwide. Nanotechnology is proud to be offering some of the fastest publication times around (less than three months on average from receipt to online publication). We offer free online access to all published papers for 30 days, ensuring that anyone with access to the internet will be able to read your paper. We were also the first journal to give our authors the opportunity to communicate their research to a wider audience through nanotechweb.org and other IOP websites. See the journal's homepage at www.iop.org/Journals/nano for more details. We are looking

  12. Foreword from the Editor-in-Chief

    Directory of Open Access Journals (Sweden)

    Jon M. Truby

    2012-04-01

    Highness the Emir, Sheikh Hamad bin Khalifa Al Thani, for this vision. I am grateful to all of those involved in the production of this and future issues, and hope the demands of our readers are met. May the journal continue to be a success. Dr. Jon M. Truby Ph.D, Editor-in-Chief

  13. Data Sharing: A New Editorial Initiative of the International Committee of Medical Journal Editors. Implications for the Editors' Network.

    Science.gov (United States)

    Alfonso, Fernando; Adamyan, Karlen; Artigou, Jean-Yves; Aschermann, Michael; Boehm, Michael; Buendia, Alfonso; Chu, Pao-Hsien; Cohen, Ariel; Cas, Livio Dei; Dilic, Mirza; Doubell, Anton; Echeverri, Dario; Enç, Nuray; Ferreira-González, Ignacio; Filipiak, Krzysztof J; Flammer, Andreas; Fleck, Eckart; Gatzov, Plamen; Ginghina, Carmen; Goncalves, Lino; Haouala, Habib; Hassanein, Mahmoud; Heusch, Gerd; Huber, Kurt; Hulín, Ivan; Ivanusa, Mario; Krittayaphong, Rungroj; Lau, Chu-Pak; Marinskis, Germanas; Mach, François; Moreira, Luiz Felipe; Nieminen, Tuomo; Oukerraj, Latifa; Perings, Stefan; Pierard, Luc; Potpara, Tatjana; Reyes-Caorsi, Walter; Rim, Se-Joong; Rødevand, Olaf; Saade, Georges; Sander, Mikael; Shlyakhto, Evgeny; Timuralp, Bilgin; Tousoulis, Dimitris; Ural, Dilek; Piek, J J; Varga, Albert; Lüscher, Thomas F

    The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship - emphasizing the importance of responsibility and accountability -, have been proposed. Last year, a new editorial initiative to foster sharing of clinical trial data was launched. This review discusses this novel initiative with the aim of increasing awareness among readers, investigators, authors and editors belonging to the Editors' Network of the European Society of Cardiology. Copyright © 2017. Publicado por Masson Doyma México S.A.

  14. Spacial Logic of Architectural Color: Werner Spillmann and the Color Planning for German Township Kirchsteigfeld%建筑色彩的空间逻辑——Werner Spillmann和德国小镇Kirchsteigfeld色彩计划

    Institute of Scientific and Technical Information of China (English)

    苟爱萍

    2007-01-01

    介绍了最早将色彩用于建筑设计的专家之一Werner Spillmann,他创立的概念色彩设计方法,即从心理学、社会学和文化学等方面对色彩进行评价与规划,并在实践中进行检验,以及德国Kirchsteigfeld的色彩计划,体现了他的设计思想.

  15. Creating OGC Web Processing Service workflows using a web-based editor

    Science.gov (United States)

    de Jesus, J.; Walker, P.; Grant, M.

    2012-04-01

    The OGC WPS (Web Processing Service) specifies how geospatial algorithms may be accessed in an SOA (Service Oriented Architecture). Service providers can encode both simple and sophisticated algorithms as WPS processes and publish them as web services. These services are not only useful individually but may be built into complex processing chains (workflows) that can solve complex data analysis and/or scientific problems. The NETMAR project has extended the Web Processing Service (WPS) framework to provide transparent integration between it and the commonly used WSDL (Web Service Description Language) that describes the web services and its default SOAP (Simple Object Access Protocol) binding. The extensions allow WPS services to be orchestrated using commonly used tools (in this case Taverna Workbench, but BPEL based systems would also be an option). We have also developed a WebGUI service editor, based on HTML5 and the WireIt! Javascript API, that allows users to create these workflows using only a web browser. The editor is coded entirely in Javascript and performs all XSLT transformations needed to produce a Taverna compatible (T2FLOW) workflow description which can be exported and run on a local Taverna Workbench or uploaded to a web-based orchestration server and run there. Here we present the NETMAR WebGUI service chain editor and discuss the problems associated with the development of a WebGUI for scientific workflow editing; content transformation into the Taverna orchestration language (T2FLOW/SCUFL); final orchestration in the Taverna engine and how to deal with the large volumes of data being transferred between different WPS services (possibly running on different servers) during workflow orchestration. We will also demonstrate using the WebGUI for creating a simple workflow making use of published web processing services, showing how simple services may be chained together to produce outputs that would previously have required a GIS (Geographic

  16. Polymeric lithography editor: Editing lithographic errors with nanoporous polymeric probes

    Science.gov (United States)

    Rajasekaran, Pradeep Ramiah; Zhou, Chuanhong; Dasari, Mallika; Voss, Kay-Obbe; Trautmann, Christina; Kohli, Punit

    2017-01-01

    A new lithographic editing system with an ability to erase and rectify errors in microscale with real-time optical feedback is demonstrated. The erasing probe is a conically shaped hydrogel (tip size, ca. 500 nm) template-synthesized from track-etched conical glass wafers. The “nanosponge” hydrogel probe “erases” patterns by hydrating and absorbing molecules into a porous hydrogel matrix via diffusion analogous to a wet sponge. The presence of an interfacial liquid water layer between the hydrogel tip and the substrate during erasing enables frictionless, uninterrupted translation of the eraser on the substrate. The erasing capacity of the hydrogel is extremely high because of the large free volume of the hydrogel matrix. The fast frictionless translocation and interfacial hydration resulted in an extremely high erasing rate (~785 μm2/s), which is two to three orders of magnitude higher in comparison with the atomic force microscopy–based erasing (~0.1 μm2/s) experiments. The high precision and accuracy of the polymeric lithography editor (PLE) system stemmed from coupling piezoelectric actuators to an inverted optical microscope. Subsequently after erasing the patterns using agarose erasers, a polydimethylsiloxane probe fabricated from the same conical track-etched template was used to precisely redeposit molecules of interest at the erased spots. PLE also provides a continuous optical feedback throughout the entire molecular editing process—writing, erasing, and rewriting. To demonstrate its potential in device fabrication, we used PLE to electrochemically erase metallic copper thin film, forming an interdigitated array of microelectrodes for the fabrication of a functional microphotodetector device. High-throughput dot and line erasing, writing with the conical “wet nanosponge,” and continuous optical feedback make PLE complementary to the existing catalog of nanolithographic/microlithographic and three-dimensional printing techniques. This new

  17. Interaction of Werner and Bloom syndrome genes with p53 in familial breast cancer.

    Science.gov (United States)

    Wirtenberger, Michael; Frank, Bernd; Hemminki, Kari; Klaes, Rüdiger; Schmutzler, Rita K; Wappenschmidt, Barbara; Meindl, Alfons; Kiechle, Marion; Arnold, Norbert; Weber, Bernhard H F; Niederacher, Dieter; Bartram, Claus R; Burwinkel, Barbara

    2006-08-01

    Mutations of the human RecQ helicase genes WRN and BLM lead to rare autosomal recessive disorders, Werner and Bloom syndromes, which are associated with premature ageing and cancer predisposition. We tested the hypothesis whether three polymorphic, non-conservative amino acid exchanges in WRN and BLM act as low-penetrance familial breast cancer risk factors. Moreover, we examined the putative impact of p53 MspI 1798G>A, which is completely linked to p53PIN3, a 16 bp insertion/duplication that has been associated with reduced p53 expression, on familial breast cancer risk. Genotyping analyses, performed on 816 BRCA1/2 mutation-negative German familial breast cancer patients and 1012 German controls, revealed a significant association of the WRN Cys1367Arg polymorphism with familial breast cancer (OR = 1.28, 95% CI 1.06-1.54) and high-risk familial breast cancer (OR = 1.32, 95% CI 1.06-1.65). The analysis of p53 MspI 1798G>A, which is completely linked to p53PIN3, showed a significantly increased familial breast cancer risk for carriers of the 16 bp insertion/duplication, following a recessive mode (OR = 2.15, 95% CI = 1.12-4.11). WRN Cys1367Arg, located in the C-terminus, the binding site of p53, is predicted to be damaging. The joint effect of WRN Cys1367Arg and p53 MspI resulted in an increased breast cancer risk compared to the single polymorphisms (OR = 3.39, 95% CI 1.19-9.71). In conclusion, our study indicates the importance of inherited variants in the WRN and p53 genes for familial breast cancer susceptibility.

  18. Mutations in the consensus helicase domains of the Werner syndrome gene

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Chang-En; Oshima, Junko; Wijsman, E.M. [Univ. of Washington, Seattle, WA (United States)] [and others

    1997-02-01

    Werner syndrome (WS) is an autosomal recessive disease with a complex phenotype that is suggestive of accelerated aging. WS is caused by mutations in a gene, WRN, that encodes a predicted 1,432-amino-acid protein with homology to DNA and RNA helicases. Previous work identified four WS mutations in the 3{prime} end of the gene, which resulted in predicted truncated protein products of 1,060-1,247 amino acids but did not disrupt the helicase domain region (amino acids 569-859). Here, additional WS subjects were screened for mutations, and the intron-exon structure of the gene was determined. A total of 35 exons were defined, with the coding sequences beginning in the second exon. Five new WS mutations were identified: two nonsense mutations at codons 369 and 889; a mutation at a splice-junction site, resulting in a predicted truncated protein of 760 amino acids; a 1-bp deletion causing a frameshift; and a predicted truncated protein of 391 amino acids. Another deletion is >15 kb of genomic DNA, including exons 19-23; the predicted protein is 1,186 amino acids long. Four of these new mutations either partially disrupt the helicase domain region or result in predicted protein products completely missing the helicase region. These results confirm that mutations in the WRN gene are responsible for WS. Also, the location of the mutations indicates that the presence or absence of the helicase domain does not influence the WS phenotype and suggests that WS is the result of complete loss of function of the WRN gene product. 63 refs., 1 fig., 5 tabs.

  19. Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population

    Directory of Open Access Journals (Sweden)

    M.A.C. Smith

    2005-07-01

    Full Text Available Werner syndrome (WS is a premature aging disease caused by a mutation in the WRN gene. The gene was identified in 1996 and its product acts as a DNA helicase and exonuclease. Some specific WRN polymorphic variants were associated with increased risk for cardiovascular diseases. The identification of genetic polymorphisms as risk factors for complex diseases affecting older people can improve their prevention, diagnosis and prognosis. We investigated WRN codon 1367 polymorphism in 383 residents in a district of the city of São Paulo, who were enrolled in an Elderly Brazilian Longitudinal Study. Their mean age was 79.70 ± 5.32 years, ranging from 67 to 97. This population was composed of 262 females (68.4% and 121 males (31.6% of European (89.2%, Japanese (3.3%, Middle Eastern (1.81%, and mixed and/or other origins (5.7%. There are no studies concerning this polymorphism in Brazilian population. These subjects were evaluated clinically every two years. The major health problems and morbidities affecting this cohort were cardiovascular diseases (21.7%, hypertension (83.7%, diabetes (63.3%, obesity (41.23%, dementia (8.0%, depression (20.0%, and neoplasia (10.8%. Their prevalence is similar to some urban elderly Brazilian samples. DNA was isolated from blood cells, amplified by PCR and digested with PmaCI. Allele frequencies were 0.788 for the cysteine and 0.211 for the arginine. Genotype distributions were within that expected for the Hardy-Weinberg equilibrium. Female gender was associated with hypertension and obesity. Logistic regression analysis did not detect significant association between the polymorphism and morbidity. These findings confirm those from Europeans and differ from Japanese population.

  20. Turnover of sulfated glycosaminoglycans in fibroblasts derived from patients with Werner's syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Cowles, E.A.; Brauker, J.H.; Anderson, R.L.

    1987-02-01

    Fibroblasts derived from patients with Werner's syndrome (WS) were incubated with radioactive sulfate to study the incorporation of 35S into glycosaminoglycans (GAGs). The accumulation of cell-associated 35S radioactivity in the GAGs of WS fibroblasts was consistently higher than parallel accumulation in normal human fibroblasts, but was substantially less than in fibroblasts derived from patients with Hurler's syndrome (HS). However, when fibroblasts were labeled with 35SO4(2-), trypsinized to remove extracellular and pericellular radioactive GAGs, replated, and chased to follow the fate of the intracellular radioactivity, both WS and normal cells showed a rapid release of the intracellular 35S, while HS cells showed little or no loss of intracellular radioactivity. The radioactivity released from WS and normal cells was of low molecular weight (LMW), eluting from gel filtration columns at the same position as free sulfate. These results establish that WS cells degrade intracellular sulfated GAGs and argue against the hypothesis that a defect in GAG degradation pathways is the basis for the increased level of cell-associated GAGs. Other possible explanations for the increased cell-associated (35S)GAGs in WS cells as compared with normal cells were also considered: increased GAG sulfation; an increase in GAG chain length; an increased rate of GAG synthesis; and a decreased rate of shedding of cell surface proteoglycan into the medium. No difference between normal and WS fibroblasts in any of the above parameters was observed. These results strongly imply that the primary biochemical defect in WS fibroblasts does not involve sulfated GAG metabolism.

  1. Werner complex deficiency in cells disrupts the Nuclear Pore Complex and the distribution of lamin B1.

    Science.gov (United States)

    Li, Zhi; Zhu, Yizhou; Zhai, Yujia; R Castroagudin, Michelle; Bao, Yifei; White, Tommy E; Glavy, Joseph S

    2013-12-01

    From the surrounding shell to the inner machinery, nuclear proteins provide the functional plasticity of the nucleus. This study highlights the nuclear association of Pore membrane (POM) protein NDC1 and Werner protein (WRN), a RecQ helicase responsible for the DNA instability progeria disorder, Werner Syndrome. In our previous publication, we connected the DNA damage sensor Werner's Helicase Interacting Protein (WHIP), a binding partner of WRN, to the NPC. Here, we confirm the association of the WRN/WHIP complex and NDC1. In established WRN/WHIP knockout cell lines, we further demonstrate the interdependence of WRN/WHIP and Nucleoporins (Nups). These changes do not completely abrogate the barrier of the Nuclear Envelope (NE) but do affect the distribution of FG Nups and the RAN gradient, which are necessary for nuclear transport. Evidence from WRN/WHIP knockout cell lines demonstrates changes in the processing and nucleolar localization of lamin B1. The appearance of "RAN holes" void of RAN corresponds to regions within the nucleolus filled with condensed pools of lamin B1. From WRN/WHIP knockout cell line extracts, we found three forms of lamin B1 that correspond to mature holoprotein and two potential post-translationally modified forms of the protein. Upon treatment with topoisomerase inhibitors lamin B1 cleavage occurs only in WRN/WHIP knockout cells. Our data suggest the link of the NDC1 and WRN as one facet of the network between the nuclear periphery and genome stability. Loss of WRN complex leads to multiple alterations at the NPC and the nucleolus.

  2. Note from the editor: [the world of work

    NARCIS (Netherlands)

    Cremers, J.

    2014-01-01

    In his From the editor, Jan Cremers (AIAS) summarises: In this issue we start beyond the European border; the authors of the first three articles tackle problems in construction labour in non-EU countries and around the globe. Swiss union officer Christopher Kelley examines the development of the co

  3. Most Business Editors Find Journalism Graduates Still Unprepared

    Science.gov (United States)

    Pardue, Mary Jane

    2014-01-01

    In 2002, a study was published in "Newspaper Research Journal" that explored the preparedness of graduating journalism students to cover business news. In 2012, a follow-up survey of business editors at the nation's daily newspapers was done to see whether progress had been made in the training of journalism students for the…

  4. Communicating specialized knowledge - negotiating knowledge communication between writer and editor

    DEFF Research Database (Denmark)

    Petersen, Margrethe

    In communicating research findings, authors of academic journal articles face the challenge of overcoming the barriers posed by the knowledge asymmetries between (a) authors and journal readership and (b) authors and editors. Considering the general taxonomy of the submission procedure and the key...

  5. IN DEFENSE OF ECORISK ASSESSMENT (LETTER TO EDITOR)

    Science.gov (United States)

    Dear Editor: We are writing to convey a more accurate portrayal of the status of ecological ("environmental" in Europe) risk assessment that was presented in the recent article by M. Power and L.S. McCarty (Fallacies in Ecological Risk Assessment Practices," August 1997, pp 370A-...

  6. Language-parametric Techniques for Language-Specific Editors

    NARCIS (Netherlands)

    De Jonge, M.

    2014-01-01

    The goal of this dissertation is to develop techniques that simplify the implementation of tool support for new languages. More specifically, we focus on language-parametric solutions for the implementation of language-specific editor support. In the first part of this dissertation we investigate ge

  7. Generating Editors for Embedded Languages: Integrating SGLR into IMP

    NARCIS (Netherlands)

    Kats, L.; Kalleberg, K.T.; Visser, E.

    2008-01-01

    Preprint of paper published in: LDTA 2008: 8th Workshop on Language Descriptions, Tools and Applications, 5 April 2008 Integrated Development Environments (IDEs) increase productivity by providing a rich user interface and rapid feedback for a specific language. Creating an editor for a specific la

  8. Domain-Specific Languages for Composable Editor Plugins

    NARCIS (Netherlands)

    Kats, L.C.L.; Kalleberg, K.T.; Visser, E.

    2010-01-01

    Modern IDEs increase developer productivity by incorporating many different kinds of editor services. These can be purely syntactic, such as syntax highlighting, code folding, and an outline for navigation; or they can be based on the language semantics, such as in-line type error reporting and reso

  9. Development and evaluation of the Reload Learning Design Editor

    NARCIS (Netherlands)

    Griffiths, David; Beauvoir, Phillip; Barrett Baxendale, Mark; Hazlewood, Paul; Oddie, Amanda

    2007-01-01

    Griffiths, D., Beauvoir, P., Baxendale, M., Hazlewood, P., Oddie, A. (2007). Development and evaluation of the Reload Learning Design Editor. Paper presented at TENCompetence Open Workshop on Current research on IMS Learning Design and Lifelong Competence Development Infrastructures, June 21-22, Ba

  10. Developing Visual Editors for High-Resolution Haptic Patterns

    DEFF Research Database (Denmark)

    Cuartielles, David; Göransson, Andreas; Olsson, Tony;

    2012-01-01

    In this article we give an overview of our iterative work in developing visual editors for creating high resolution haptic patterns to be used in wearable, haptic feedback devices. During the past four years we have found the need to address the question of how to represent, construct and edit high...

  11. From the editors: Finalizing a stage Editorial: Finalizando una etapa

    Directory of Open Access Journals (Sweden)

    Pep Simo

    2007-07-01

    Full Text Available This editorial briefly summarizes the work done by the editorial team of Intangible Capital in the last three years. We also inform the readers of Intagible Capital about the changes in the editorial position.En la presente editorial se sintetiza el trabajo de los últimos tres años y se presenta el relevo en el cargo de editor.

  12. Enhancing Computer Assisted Assessment Using Rubrics in a QTI Editor

    NARCIS (Netherlands)

    Santos, Patricia; Colina, Xavier; Hernández-Leo, Davinia; Melero, Javier; Blat, Josep

    2009-01-01

    Santos,P., Colina, X., Hernández-Leo, D., Melero, J., & Blat, J. (accepted). Enhancing Computer Assisted Assessment Using Rubrics in a QTI Editor. The 9th IEEE International Conference on Advanced Learning Technologies. July, 14-18, 2009, Riga, Latvia.

  13. Most Business Editors Find Journalism Graduates Still Unprepared

    Science.gov (United States)

    Pardue, Mary Jane

    2014-01-01

    In 2002, a study was published in "Newspaper Research Journal" that explored the preparedness of graduating journalism students to cover business news. In 2012, a follow-up survey of business editors at the nation's daily newspapers was done to see whether progress had been made in the training of journalism students for the…

  14. From the Editor: Changes and new directions of Intangible Capital

    Directory of Open Access Journals (Sweden)

    Jose Maria Sallan

    2007-08-01

    Full Text Available In this editorial, I notify to the community the adoption of the Open Journal Systems platform as the publishing environment of Intangible Capital. I also give notice of the new initiatives that the editors of the journal will develop in the near future.

  15. Publishing in Educational Psychology Journals: Comments from Editors

    Science.gov (United States)

    Nihalani, Priya K.; Mayrath, Michael C.

    2008-01-01

    The following paper emphasizes the importance of publishing and learning how to publish in educational psychology journals. We have compiled a set of recommendations based on advice from editors in the field and several other sources on how to publish. Additionally, this paper provides a step-by-step guide that graduate students and junior faculty…

  16. Relation between initial conditions and entanglement sudden death for two-qubit extended Werner-like states

    Institute of Scientific and Technical Information of China (English)

    Yang Bai-Yuan; Fang Mao-Fa; Huang Jiang

    2013-01-01

    In this paper,the dynamical behavior of entanglement of an uncoupled two-qubit system,which interacts with independent identical amplitude damping environments and is initially prepared in the extended Werner-like (EWL) states,is investigated.The results show that whether entanglement sudden death (ESD) of an EWL state will occur or not depends on initial purity and concurrence.The boundaries between ESD states and ESD-free states for two kinds of EWL states are found to be different.Furthermore,some regions are shown where ESD states can be transformed into ESD-free states by local unitary operations.

  17. Herlyn-Werner-Wunderlich Syndrome Consisting of Uterine Didelphys, Obstructed Hemivagina and Ipsilateral Renal Agenesis in a Newborn

    Directory of Open Access Journals (Sweden)

    Tsung-Hsin Wu

    2012-02-01

    Full Text Available Herlyn-Werner-Wunderlich (HWW syndrome is a rare variant of Müllerian duct anomalies consisting of uterine didelphys, obstructed hemivagina, and ipsilateral renal agenesis. Patients with HWW syndrome are usually asymptomatic until menarche, when they present with acute lower abdominal pain. Here we report a case of a female newborn with right renal agenesis diagnosed during the pregnancy. The patient presented with a protruding mass over the vaginal introitus that was associated with an obstructed hemivagina and uterine didelphys.

  18. Werner Gaus:室内循环水养殖,中国还没读懂

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Werner Gaus认为目前中国政府主导的循环水养殖系统研究,还是多数建立在借鉴国外系统或者引用欧洲系统的部分原理,只是借鉴到皮毛,没有触及真正核心的原理与技术,这是很多设计和设备在欧洲系统里好用,而在国内应用时效果不理想的症结所在。

  19. F. Oliver Brachfeld y Werner Wolff: dos figuras en los inicios de la Sociedad Interamericana de Psicología

    OpenAIRE

    Ramón León

    2012-01-01

    F. Oliver Brachfeld (1908-1967) y Werner Wolff (1904-1957) fueron dos psicólogos europeos emigrados a América del Sur (Brachfeld) y a los Estados Unidos de Norteamérica (Wolff) que desempeñaron importantes funciones en los años iniciales de la Sociedad Interamericana de Psicología (SIP). Brachfeld fue su Presidente entre 1953 y 1955, en tanto que Wolff fue uno de los gestores de su creación (al lado de Oswaldo Robles, Guillermo Dávila y Rogelio Díaz-Guerrero), su primer Vicepresidente entre 1...

  20. [1999, the year of fired editors-in-chief].

    Science.gov (United States)

    2000-01-01

    In the past year three editors of medical scientific journals stepped back, a remarkable fact for a relatively quiet profession. G. Lundberg was dismissed. J. Kassirer was forced out and F. Meijman resigned. There are differences and similarities in these events. Lundberg of The Journal of the American Medical Association (JAMA) was dismissed because of his interference with regular points of view of the board of the American Medical Association, whereas Kassirer of The New England Journal of Medicine was forced out mainly because of his refusal to allow use of the name and reputation of his journal for other medical and lay publications by the Massachusetts Medical Association; Meijman resigned because he disagreed with the changes in the scientific contents of Huisarts en Wetenschap (General Practitioner and Medical Science) proposed by the board of the general practitioners' association that owns the journal. The similarity is that editorial freedom appears to be a relative concept. Owners, whether societies or publishers, can fire displeasing editors or force them to leave. The consequences could be harmful, to the owners, but especially to the journals, because of loss of impact, credibility and trust by authors, reviewers and readers. The only basis for a constructive co-operation between owners and editors is mutual trust. Immediate firing of editors is not possible at the Nederlands Tijdschrift voor Geneeskunde (Dutch Journal of Medicine). The association that owns the journal consists of (former) members of the editorial board. A committee of the association assesses every year the editorial decisions and policies retrospectively. Subsequently the editors may be reappointed for another year by a vote of the general assembly of the association. If they are not reappointed, an administrative procedure will be initiated to terminate their contract.

  1. Sébastien Lechevalier (editor), The Great Transformation of Japanese Capitalism. London: Routledge, 2014. 240 pp

    DEFF Research Database (Denmark)

    Kravtsova, Victoria

    2015-01-01

    Book review of: Sébastien Lechevalier (editor), The Great Transformation of Japanese Capitalism. London: Routledge, 2014.......Book review of: Sébastien Lechevalier (editor), The Great Transformation of Japanese Capitalism. London: Routledge, 2014....

  2. Editors-in-Chief of Medical Journals: Are They Experts, Authorities, Both, or Neither?

    Science.gov (United States)

    Zsindely, Sandor; Schubert, Andras

    1989-01-01

    Uses citation analysis to study the professional status and influence of the editors-in-chief of 769 medical journals. Finds that these editors-in-chief are, at least in their own specialties, not necessarily experts but authorities. (SR)

  3. EDITORIAL: Outgoing Editor-in-Chief Outgoing Editor-in-Chief

    Science.gov (United States)

    Hauptmann, Peter

    2012-01-01

    I started in 2002 as Editor-in-Chief of a well established journal—MST (Measurement Science and Technology). It was a time when modern means of communication offered new opportunities for the scientific community—for all scientists and engineers whether at universities, in industry or at other institutions—to access better quality information in a shorter time. This development helped us to be more efficient in our daily scientific work and to anticipate new trends faster than before. A flood of information was created by different search engines. A few online journals or journals published in emerging countries with a similar profile to MST appeared on the market. MST had to provide new answers in response to these developments. In 2002 I postulated two requirements to the journal. Firstly, the publisher has to be up to date. My impression over the years has been that IOPP is excellently organized. That has made it easier for the board members and all our reviewers to concentrate on the scientific aspects of our input to the journal. During all my visits to Bristol or my contacts with the IOPP staff I always met very professional and enthusiastic staff members. They have not only supported and encouraged the ideas and initiatives of the Editorial Board members, but they have also worked hard on establishing one of the most effective journal operations in the field of measurement science and technology. Many authors are well aware of this. Thus I am able to declare that the first requirement for a successful journal has been met. Secondly, the scientific level has to be high and the journal should attract readers from all over the world. This task was the responsibility of the Editorial Board members and of myself. Our strategy was on the one hand to ensure continuity in MST but on the other hand to be open to new trends and developments. Examples of these new aspects of the journal are fields like micro- and nanometrology, measurement techniques for

  4. The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures.

    Science.gov (United States)

    Kamath-Loeb, Ashwini; Loeb, Lawrence A; Fry, Michael

    2012-01-01

    Loss of Werner syndrome helicase-exonuclease (WRN) or of its homolog Bloom syndrome helicase (BLM) results in different inherited disorders. Whereas Werner syndrome is characterized by premature onset of aging and age-associated diseases, Bloom syndrome involves developmental abnormalities and increased predisposition to diverse malignancies. To identify biochemical differences between WRN and BLM that might contribute to the dissimilar outcomes of their loss, we compared their abilities to unwind and bind in vitro diverse DNA structures. Full-length recombinant WRN and BLM proteins expressed in and purified from Sf9 insect cells unwound to comparable extents and with similar K(m) values partial DNA duplex, splayed arm DNA and G'2 bimolecular quadruplex DNA. However, WRN resolved bubble DNA ∼25-fold more efficiently than BLM. The two enzymes were mainly distinguished by their contrasting abilities to bind DNA. WRN bound partial duplexes, bubble and splayed arm DNA and G'2 bimolecular and G4 four-molecular quadruplexes with dissociation constants of 0.25 to 25 nM. By contrast, BLM formed substantial complexes with only G4 quadruplex DNA while binding only marginally other DNA structures. We raise the possibility that in addition to its enzymatic activities WRN may act as a scaffold for the assembly on DNA of additional DNA processing proteins.

  5. The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures.

    Directory of Open Access Journals (Sweden)

    Ashwini Kamath-Loeb

    Full Text Available Loss of Werner syndrome helicase-exonuclease (WRN or of its homolog Bloom syndrome helicase (BLM results in different inherited disorders. Whereas Werner syndrome is characterized by premature onset of aging and age-associated diseases, Bloom syndrome involves developmental abnormalities and increased predisposition to diverse malignancies. To identify biochemical differences between WRN and BLM that might contribute to the dissimilar outcomes of their loss, we compared their abilities to unwind and bind in vitro diverse DNA structures. Full-length recombinant WRN and BLM proteins expressed in and purified from Sf9 insect cells unwound to comparable extents and with similar K(m values partial DNA duplex, splayed arm DNA and G'2 bimolecular quadruplex DNA. However, WRN resolved bubble DNA ∼25-fold more efficiently than BLM. The two enzymes were mainly distinguished by their contrasting abilities to bind DNA. WRN bound partial duplexes, bubble and splayed arm DNA and G'2 bimolecular and G4 four-molecular quadruplexes with dissociation constants of 0.25 to 25 nM. By contrast, BLM formed substantial complexes with only G4 quadruplex DNA while binding only marginally other DNA structures. We raise the possibility that in addition to its enzymatic activities WRN may act as a scaffold for the assembly on DNA of additional DNA processing proteins.

  6. Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells.

    Science.gov (United States)

    Li, Baomin; Iglesias-Pedraz, Juan Manuel; Chen, Leng-Ying; Yin, Fei; Cadenas, Enrique; Reddy, Sita; Comai, Lucio

    2014-04-01

    The Werner syndrome protein (WRN) is a nuclear protein required for cell growth and proliferation. Loss-of-function mutations in the Werner syndrome gene are associated with the premature onset of age-related diseases. How loss of WRN limits cell proliferation and induces replicative senescence is poorly understood. Here, we show that WRN depletion leads to a striking metabolic shift that coordinately weakens the pathways that generate reducing equivalents for detoxification of reactive oxygen species and increases mitochondrial respiration. In cancer cells, this metabolic shift counteracts the Warburg effect, a defining characteristic of many malignant cells, resulting in altered redox balance and accumulation of oxidative DNA damage that inhibits cell proliferation and induces a senescence-like phenotype. Consistent with these findings, supplementation with antioxidant rescues at least in part cell proliferation and decreases senescence in WRN-knockdown cancer cells. These results demonstrate that WRN plays a critical role in cancer cell proliferation by contributing to the Warburg effect and preventing metabolic stress.

  7. 出版:沃纳·比肖夫(WERNER BISCHOF)纪念光盘出版

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    “如果不是沃纳比肖夫(Werner Bischof,1918-1954,瑞士人)的名字,便是他的照片在他去世以后闻名于世。在一个多世纪里他是最杰出的新闻记者之一。这是《美国ICP摄影百科全书》对比肖夫的评价,今年是比肖夫去世50周年纪念,2004年9月3日,在法国佩皮尼扬国际报道摄影节期间,为纪念这位杰出的摄影家特别举行了《沃纳·比肖夫:一位摄影师的生活和作品》(WERNER BISCHOF,Life and Work of a Photographer)纪念光盘的发行仪式。

  8. FLAn: A Free Hypermedia Editor to Create Foreign Language Learning Units

    Science.gov (United States)

    Kilickaya, Ferit, Ed.

    2011-01-01

    Glossing words is done via special software called multimedia editors. Foreign Language Annotator (FLAn), created by Thibeault (2011), is one of these multimedia editors. FLAn (Foreign Language Annotator), a free hypermedia editor that works on both Macs and PCs, allows instructors to turn static texts into dynamic learning units by attaching…

  9. Artur Gas, editor de Josep Pla: breu història d'Ediciones Alfa

    OpenAIRE

    Pla, Xavier

    1997-01-01

    Repàs de la trajectòria professional com a editor, començant com a editor de caire socialista i acabant col·laborant amb la dictadura de Primo de Rivera. Es fa especial menció al seu paper com a editor de Josep Pla i a la seva editorial, Ediciones Alfa

  10. Competition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteins

    Directory of Open Access Journals (Sweden)

    Orren David K

    2006-01-01

    Full Text Available Abstract Background The premature aging and cancer-prone Werner and Bloom syndromes are caused by defects in the RecQ helicase enzymes WRN and BLM, respectively. Recently, both WRN and BLM (as well as several other RecQ members have been shown to possess a strand annealing activity in addition to the requisite DNA unwinding activity. Since an annealing function would appear to directly oppose the action of a helicase, we have examined in this study the dynamic equilibrium between unwinding and annealing mediated by either WRN or BLM. Results Our investigation into the competition between annealing and unwinding demonstrates that, under standard reaction conditions, WRN- or BLM-mediated annealing can partially or completely mask unwinding as measured in standard helicase assays. Several strategies were employed to suppress the annealing activity so that the actual strength of WRN- or BLM-dependent unwinding could be more accurately assessed. Interestingly, if a DNA oligomer complementary to one strand of the DNA substrate to be unwound is added during the helicase reaction, both WRN and BLM unwinding is enhanced, presumably by preventing protein-mediated re-annealing. This strategy allowed measurement of WRN-catalyzed unwinding of long (80 base pair duplex regions and fully complementary, blunt-ended duplexes, both of which were otherwise quite refractory to the helicase activity of WRN. Similarly, the addition of trap strand stimulated the ability of BLM to unwind long and blunt-ended duplexes. The stimulatory effect of the human replication protein A (hRPA, the eukaryotic single-stranded DNA binding protein on both WRN- and BLM-dependent unwinding was also re-examined in light of its possible role in preventing re-annealing. Our results show that hRPA influences the outcome of WRN and BLM helicase assays by both inhibiting re-annealing and directly promoting unwinding, with the larger contribution from the latter mechanism. Conclusion These

  11. Competition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteins.

    Science.gov (United States)

    Machwe, Amrita; Lozada, Enerlyn M; Xiao, Liren; Orren, David K

    2006-01-13

    The premature aging and cancer-prone Werner and Bloom syndromes are caused by defects in the RecQ helicase enzymes WRN and BLM, respectively. Recently, both WRN and BLM (as well as several other RecQ members) have been shown to possess a strand annealing activity in addition to the requisite DNA unwinding activity. Since an annealing function would appear to directly oppose the action of a helicase, we have examined in this study the dynamic equilibrium between unwinding and annealing mediated by either WRN or BLM. Our investigation into the competition between annealing and unwinding demonstrates that, under standard reaction conditions, WRN- or BLM-mediated annealing can partially or completely mask unwinding as measured in standard helicase assays. Several strategies were employed to suppress the annealing activity so that the actual strength of WRN- or BLM-dependent unwinding could be more accurately assessed. Interestingly, if a DNA oligomer complementary to one strand of the DNA substrate to be unwound is added during the helicase reaction, both WRN and BLM unwinding is enhanced, presumably by preventing protein-mediated re-annealing. This strategy allowed measurement of WRN-catalyzed unwinding of long (80 base pair) duplex regions and fully complementary, blunt-ended duplexes, both of which were otherwise quite refractory to the helicase activity of WRN. Similarly, the addition of trap strand stimulated the ability of BLM to unwind long and blunt-ended duplexes. The stimulatory effect of the human replication protein A (hRPA, the eukaryotic single-stranded DNA binding protein) on both WRN- and BLM-dependent unwinding was also re-examined in light of its possible role in preventing re-annealing. Our results show that hRPA influences the outcome of WRN and BLM helicase assays by both inhibiting re-annealing and directly promoting unwinding, with the larger contribution from the latter mechanism. These findings indicate that measurements of unwinding by WRN

  12. PREFACE: Introductory remarks from the Editors Introductory remarks from the Editors

    Science.gov (United States)

    Knobloch, E.; Meseguer, A.; Marques, F.

    2012-06-01

    The local organizers of the 4th BIFD (Bifurcations and Instabilities in Fluid Dynamics) Symposium held in Barcelona on 18-21 July 2011 would like to thank the editors of Fluid Dynamics Research for offering us the opportunity of publishing a peer-reviewed special issue of the journal with a selection of the contributions presented at this conference. We thank both the authors and the referees for working with us on the rather tight schedule necessary to release the issue within one year of the date of the conference. We also thank the invited speakers, B Eckhardt, L Tuckerman, and J M Vega, for contributing keynote papers to this special issue. The series of BIFD symposia started as a small workshop in Madeira, Portugal, in 2004 with no more than 20 participants. This number increased rapidly during the second and third symposia held in 2006 (Denmark) and 2009 (United Kingdom), with 40 and 110 participants, respectively. The 4th BIFD symposium has consolidated this event as one of the leading conferences in hydrodynamic stability, with nearly 200 participants from around the world. The main goal of this conference is to bring together scientists and engineers from different disciplines directly or indirectly related to fluid dynamics, bifurcation theory and hydrodynamic stability theory. The conference covered many research areas within the aforementioned fields, ranging from thermal, shear and centrifugal flows to biofluids, films, drops, viscoelastic flows and magnetohydrodynamics. The structure of the conference, with invited plenary talks and focused sessions, helped the participants find their home in the conference and share state-of-the-art knowledge within the field of hydrodynamic instabilities. The financial support from MICINN (Spanish Ministry of Science and Innovation, Grant no FIS2009-08065-E) and UPC (Universitat Politècnica de Catalunya) is greatly appreciated. The local organizers would also like to thank ETSAB (Barcelona School of Architecture

  13. William E. Edmonston, Jr.: Editor, 1968-1976.

    Science.gov (United States)

    Kihlstrom, John F; Frischholz, Edward J

    2010-10-01

    This article is part of an occasional series profiling editors of the American Journal of Clinical Hypnosis (AJCH). William E. Edmonston was the second editor, succeeding Milton H. Erickson. His research focused on the use of conditioning paradigms and psychophysiological measures to explore a wide variety of hypnotic phenomena, leading to a "neo-Pavlovian" theory of neutral hypnosis as physiological relaxation (anesis). A longtime professor of psychology at Colgate University, he created an interdisciplinary undergraduate major in neuroscience, and was named New York State College Professor of the Year in 1988. He gave the Journal a new look, and a greater balance of clinical and experimental papers. The article also provides background on George Barton Cutten, George H. Estabrooks, and Frank A. Pattie, pioneers of hypnosis who were linked to Edmonston.

  14. A Studyon the Competence Map for Digital Publishing Editors

    Directory of Open Access Journals (Sweden)

    Ming-Ju Hsu

    2014-04-01

    Full Text Available The aims of the study were to understand the required competences for editors working in today’s technology-driven publishing industry. The study used the Qualitative Research Method, which included Document Analysis, Functional analysis, In-Depth Interviews with Experts, Experts Meeting, Triangulation and combined with the qualitative analysis software, ATLAS.ti, to analyze a wide range of competence parameters; a relationship-network diagram was then compiled. The results of this study were 4 main functions and 14 sub-functions and their job function concepts of competence to establish Competence Map for Digital Publishing Editors. The study results will be provided as a useful guidance and criteria for publishing industry to recruit, colleges and universities to teach and train and government to select talents. It also should help to assist editors’ transformation and improve their working efficiencies as well as enhancing the development of Digital Publishing industries in Taiwan.

  15. Space Weather Editors in Transition: Hail and Farewell

    Science.gov (United States)

    Knipp, Delores J.

    2017-02-01

    I hope you will join me in welcoming Dr. Daniel Welling of University of Michigan and Dr. T. Paul O'Brien of the Aerospace Corporation to the Space Weather (SWE) editorial team. Dan and Paul have answered the call to fill the shoes of two departing editors: Dr. Howard Singer and Dr. Barbara Giles. Dan brings insight related to space weather model development, while Paul brings expertise in the geospace radiation environment.

  16. ALIFE: A Geometry Editor and Parser for FLUKA

    CERN Document Server

    CERN. Geneva

    1998-01-01

    ALIFE is an editor and parser for the FLUKA geometry and detector definitions written in the Tcl/Tk programming language. Its syntax simplifies the preparation and maintenance of FLUKA input cards for geometry and materials as well as tracking and scoring options. It supports a modular structure for the geometry definition providing a very efficient way for several users to work on the same geometry.

  17. On the presence of Bufo nasicus Werner in Guiana, with a redescription of the species on the basis of recently collected material

    NARCIS (Netherlands)

    Hoogmoed, M.S.

    1977-01-01

    During research on material recently collected in Guyana and in Venezuelan Guiana, several specimens of the rare toad Bufo nasicus Werner, thus far only known from the holotype without known origin, were discovered. On the basis of this material the species is redescribed and some notes on its natur

  18. Werner-Type Matrix Valued Rational Interpolation and Its Recurrence Algorithms%Werner型矩阵有理插值和递推算法

    Institute of Scientific and Technical Information of China (English)

    顾传青; 王金波

    2004-01-01

    In this paper, a practical Werner-type continued fraction method for solving matrix valued rational interpolation problem is provided by using a generalized inverse of matrices. In order to reduce the continued fraction form to rational function form of the interpolants, an efficient forward recurrence algorithm is obtained.

  19. Werner综合征伴脑膜瘤一例并文献复习%Meningioma arising in Werner syndrome, a case report and literature review

    Institute of Scientific and Technical Information of China (English)

    郝淑煜; 张力伟; 孙彦辉; 辛宇; 吴震; 张俊廷; 王忠诚

    2009-01-01

    Objective To report a case of Werner syndrome with meningioma in cavernous sinus and clivus, and review the relative literatures. Methods A pre-sigmoid sinus approach was performed for the meningioma, and we analyzed the genome sequence of the patient. Results According to her clinical features and result of genetic test of WRN, she was diagnosed as Werner's syndrome. The meningioma was totally removed. Conclusions This is the first case of Werner syndrome with meningioma in Chinese, we should emphasize further study of the associated genes of Werner syndrome and clinical manifestation.%目的 报告1例伴发海绵窦斜坡脑膜瘤的Werner综合征患者并文献复习.方法 通过乙状窦前入路切除肿瘤,并进行相关基因检查.结果 患者衰老面容,双眼白内障,硬皮病样皮肤改变及WRN基因检测结果 ,符合Werner综合征诊断,颅内肿瘤切除效果满意.结论 首次报告了中国人群中伴发脑膜瘤的Werner综合征病例,对Werner综合征相关基因及临床表现仍待进一步研究.

  20. The Historical Foundation of Learning Disabilities: A Quantitative Synthesis Assessing the Validity of Strauss and Werner's Exogenous versus Endogenous Distinction of Mental Retardation.

    Science.gov (United States)

    Kavale, Kenneth A.; Forness, Steven R.

    1985-01-01

    The paper reviews research of A. Strauss and H. Werner on behavioral differences between exogeneous (brain injured) and endogeneous (familial-cultural) mental retardation using quantitative methods of research synthesis. Findings offer little empirical support for the presumed behavioral differences and reveal considerable overlap among the…

  1. Ethnic-Specific WRN Mutations in South Asian Werner Syndrome Patients: Potential Founder Effect in Patients with Indian or Pakistani Ancestry.

    Science.gov (United States)

    Saha, Bidisha; Lessel, Davor; Nampoothiri, Sheela; Rao, Anuradha S; Hisama, Fuki M; Peter, Dincy; Bennett, Chris; Nürnberg, Gudrun; Nürnberg, Peter; Martin, George M; Kubisch, Christian; Oshima, Junko

    2013-05-01

    Werner syndrome is a rare autosomal recessive disorder characterized by multiple features consistent with accelerated aging. It is caused by mutations in the WRN gene, which encodes a RecQ type helicase. To date, more than 70 disease-causing mutations have been reported. While founder mutations and a corresponding relatively high incidence of WS have been reported in Japan and Sardinia, such mutations have not been previously described among patients of South Asian descent. Here we report two novel WRN mutations in three pedigrees. A homozygous c.561A>G mutation in exon 6 was identified both in a pedigree from Kerala, India and in a British patient of Pakistani ancestry. Although c.561A>G does not alter the corresponding amino acid (p.K187K), it creates a cryptic splice site resulting in a 98bp deletion at the mRNA level (r.557-654del98) followed by a frameshift (p.K187fs). These two cases shared the same haplotype across the WRN gene, and were distinct from another Indian Werner patient with a homozygous stop codon mutation, c.2855 C>A (p.S952*) in exon 24. As the Indian population increases and the awareness of Werner syndrome grows, we anticipate that more cases will be identified with these founder mutations among South Asian Werner syndrome patients.

  2. CMS Configuration Editor: GUI based application for user analysis job

    Science.gov (United States)

    de Cosa, A.

    2011-12-01

    We present the user interface and the software architecture of the Configuration Editor for the CMS experiment. The analysis workflow is organized in a modular way integrated within the CMS framework that organizes in a flexible way user analysis code. The Python scripting language is adopted to define the job configuration that drives the analysis workflow. It could be a challenging task for users, especially for newcomers, to develop analysis jobs managing the configuration of many required modules. For this reason a graphical tool has been conceived in order to edit and inspect configuration files. A set of common analysis tools defined in the CMS Physics Analysis Toolkit (PAT) can be steered and configured using the Config Editor. A user-defined analysis workflow can be produced starting from a standard configuration file, applying and configuring PAT tools according to the specific user requirements. CMS users can adopt this tool, the Config Editor, to create their analysis visualizing in real time which are the effects of their actions. They can visualize the structure of their configuration, look at the modules included in the workflow, inspect the dependences existing among the modules and check the data flow. They can visualize at which values parameters are set and change them according to what is required by their analysis task. The integration of common tools in the GUI needed to adopt an object-oriented structure in the Python definition of the PAT tools and the definition of a layer of abstraction from which all PAT tools inherit.

  3. Authors, editors, and the signs, symptoms and causes of plagiarism

    Directory of Open Access Journals (Sweden)

    Karen Shashok

    2011-01-01

    Full Text Available Plagiarism and inadequate citing appear to have reached epidemic proportions in research publication. This article discusses how plagiarism is defined and suggests some possible causes for the increase in the plagiarism disease. Most editors do not have much tolerance for text re-use with inadequate citation regardless of reasons why words are copied from other sources without correct attribution. However, there is now some awareness that re-use of words in research articles to improve the writing or "the English" (which has become a common practice should be distinguished from intentional deceit for the purpose of stealing other authors′ ideas (which appears to remain a very rare practice. Although it has become almost as easy for editors to detect duplicate text as it is for authors to re-use text from other sources, editors often fail to consider the reasons why researchers resort to this strategy, and tend to consider any text duplication as a symptom of serious misconduct. As a result, some authors may be stigmatized unfairly by being labeled as plagiarists. The article concludes with practical advice for researchers on how to improve their writing and citing skills and thus avoid accusations of plagiarism.

  4. An editor's considerations in publishing industry-sponsored studies.

    Science.gov (United States)

    Droller, Michael J

    2015-03-01

    The fundamental responsibility of a journal editor is to assure that studies accepted for publication provide rigorous original scientific information and reviews that are considered important to the readership. The fundamental requirements of such reports from an editor's perspective include objectivity and transparency in each of the study design, implementation of investigation methods, acquisition of data, inclusive analysis and interpretation of results, appropriate application of statistical methods, presentation of outcomes in the context of a balanced and comprehensive review of relevant literature, and meaningful conclusions. In proceeding on these presumptions, editors then have the responsibility of obtaining rigorous, objective, and constructive reviews of these reports so that they can make an unbiased decision regarding their disposition. The fundamental objective in this is to enhance the ultimate scientific validity and value of the work if and when it is accepted for publication. Guidelines have been advanced by several organizations to identify how such editorial responsibilities can be fulfilled. These guidelines also pertain to investigators, authors, and sponsors of the studies, which the various reports and reviews describe. The present article reviews these guidelines as they relate to both industry-sponsored and investigator-initiated investigations and as relevant to the variety of reports that a scientific/medical journal such as Urologic Oncology: Seminars and Original Investigations receives for publication.

  5. Statement on Publication Ethics for Editors and Publishers

    Science.gov (United States)

    2016-01-01

    The digitization and related developments in journal editing and publishing necessitate increasing the awareness of all stakeholders of science communication in the emerging global problems and possible solutions. Journal editors and publishers are frequently encountered with the fast-growing problems of authorship, conflicts of interest, peer review, research misconduct, unethical citations, and inappropriate journal impact metrics. While the number of erroneous and unethical research papers and wasteful, or 'predatory', journals is increasing exponentially, responsible editors are urged to 'clean' the literature by correcting or retracting related articles. Indexers are advised to implement measures for accepting truly influential and ethical journals and delisting sources with predatory publishing practices. Updating knowledge and skills of authors, editors and publishers, developing and endorsing recommendations of global editorial associations, and (re)drafting journal instructions can be viewed as potential tools for improving ethics of academic journals. The aim of this Statement is to increase awareness of all stakeholders of science communication of the emerging ethical issues in journal editing and publishing and initiate a campaign of upgrading and enforcing related journal instructions. PMID:27510376

  6. Handing Over the ATLAS eNews Scientific Editor Task

    CERN Multimedia

    P. Jenni

    2006-01-01

    The ATLAS eNews are now established since many years as a lively source of stories about the construction of our detector as well as the preparations for the physics running to come. The human touch in telling these stories is important, and to stimulate and motivate the article writers to include also this side of our work is one of the tasks for the Scientific Editor of the eNews. Joleen ('Jo') Pater has been the enthusiastic and competent 'skipper' for the last two years keeping the eNews on track. The whole Collaboration owes her a great and very hearty thank-you! Pauline Gagnon has kindly accepted to take up the challenge for the next couple of years. She will have the privilege to be the editor when we will see the first collisions with ATLAS! I wish her all the best for this new task. Outgoing and incoming editors of the ATLAS E-news: Jo Pater (left) and Pauline Gagnon (right)

  7. The XML Metadata Editor of GFZ Data Services

    Science.gov (United States)

    Ulbricht, Damian; Elger, Kirsten; Tesei, Telemaco; Trippanera, Daniele

    2017-04-01

    Following the FAIR data principles, research data should be Findable, Accessible, Interoperable and Reuseable. Publishing data under these principles requires to assign persistent identifiers to the data and to generate rich machine-actionable metadata. To increase the interoperability, metadata should include shared vocabularies and crosslink the newly published (meta)data and related material. However, structured metadata formats tend to be complex and are not intended to be generated by individual scientists. Software solutions are needed that support scientists in providing metadata describing their data. To facilitate data publication activities of 'GFZ Data Services', we programmed an XML metadata editor that assists scientists to create metadata in different schemata popular in the earth sciences (ISO19115, DIF, DataCite), while being at the same time usable by and understandable for scientists. Emphasis is placed on removing barriers, in particular the editor is publicly available on the internet without registration [1] and the scientists are not requested to provide information that may be generated automatically (e.g. the URL of a specific licence or the contact information of the metadata distributor). Metadata are stored in browser cookies and a copy can be saved to the local hard disk. To improve usability, form fields are translated into the scientific language, e.g. 'creators' of the DataCite schema are called 'authors'. To assist filling in the form, we make use of drop down menus for small vocabulary lists and offer a search facility for large thesauri. Explanations to form fields and definitions of vocabulary terms are provided in pop-up windows and a full documentation is available for download via the help menu. In addition, multiple geospatial references can be entered via an interactive mapping tool, which helps to minimize problems with different conventions to provide latitudes and longitudes. Currently, we are extending the metadata editor

  8. Greetings from the new Editor-in-Chief, Ronald Stambaugh Greetings from the new Editor-in-Chief, Ronald Stambaugh

    Science.gov (United States)

    Stambaugh, Ronald

    2012-04-01

    I am very pleased to join the outstanding leadership team for the journal Nuclear Fusion as Scientific Editor. The journal's high position in the field of fusion energy research derives in no small measure from the efforts of the IAEA team in Vienna, the production and marketing of IOP Publishing, the Board of Editors led by its chairman Mitsuru Kikuchi, the Associate Editor for Inertial Confinement Max Tabak and the outgoing Scientific Editor, Paul Thomas. During Paul's five year tenure submissions have grown by over 40%. The usage of the electronic journal has grown year by year with about 300 000 full text downloads of Nuclear Fusion articles in 2011, an impressive figure due in part to the launch of the full 50 year archive. High quality has been maintained while times for peer review and publishing have been reduced and the journal achieved some of the highest impact factors ever (as high as 4.27). The journal has contributed greatly to building the international scientific basis for fusion. I was privileged to serve from 2003 to 2010 as chairman of the Coordinating Committee for the International Tokamak Physics Activity (ITPA) which published in Nuclear Fusion the first ITER Physics Basis (1999) and its later update (2007). The scientific basis that has been developed to date for fusion has led to the construction of major facilities to demonstrate the production of power-plant relevant levels of fusion reactions. We look forward to the journal continuing to play a key role in the international effort toward fusion energy as these exciting major facilities and the various approaches to fusion continue to be developed. It is clear that Nuclear Fusion maintains its position in the field because of the perceived high quality of the submissions, the refereeing and the editorial processes, and the availability and utility of the online journal. The creation of the Nuclear Fusion Prize, led by the Board of Editors chairman Mitsuru Kikuchi, for the most outstanding

  9. Alcance y Función de las Teorias Físicas em Hylary Putnam y Werner Heisenberg

    Directory of Open Access Journals (Sweden)

    Christian de Ronde

    2013-08-01

    Full Text Available In this work we attempt to analyze the intra-theoretic characterization provided by Hilary Putnam and Werner Heisenberg between quantum mechanics and other theories. The first defended the idea that physical theories include macro principles that under specific definite historical conditions can be revised on the light of rival principles. Putnam will concentrate in the impact that quantum mechanics has produced in the classical image of knowledge. Heisenberg, on the other hand, develops his analysis from the notion of closed theories, assuming the independence and incommensurability of physical theories. These divergences between the two authors will allow us to analyze how the disagreement in the consideration of the status of physical theories, goes deeper into more profound aspects related to the nature of knowledge and the relation between theory and world

  10. Interstitial Lung Disease in Werner Syndrome: A Case Report of a 55-Year-Old Male Patient

    Directory of Open Access Journals (Sweden)

    Tiphaine Goletto

    2015-01-01

    Full Text Available Werner syndrome (WS is a progeroid or premature aging syndrome characterized by early onset of age-related pathologies and cancer. The average life expectancy of affected people is 52.8 years and tends to increase. The major causes of death are malignancy and myocardial infarction. Increased telomere attrition and decay are thought to play a causative role in the clinical and pathological manifestations of the disease. Although telomere length, with or without germline mutation, is known to be associated with interstitial lung disease, the latter is not associated with WS. To the best of our knowledge, we report the first case describing a WS patient with fatal ILD. This case suggests that older patients with WS could develop ILD. Clinical outcome of WS patients may thus be improved by counselling them regarding smoking cessation or other exposure and by proposing antifibrotic therapy.

  11. Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.

    Science.gov (United States)

    Zhang, Weiqi; Li, Jingyi; Suzuki, Keiichiro; Qu, Jing; Wang, Ping; Zhou, Junzhi; Liu, Xiaomeng; Ren, Ruotong; Xu, Xiuling; Ocampo, Alejandro; Yuan, Tingting; Yang, Jiping; Li, Ying; Shi, Liang; Guan, Dee; Pan, Huize; Duan, Shunlei; Ding, Zhichao; Li, Mo; Yi, Fei; Bai, Ruijun; Wang, Yayu; Chen, Chang; Yang, Fuquan; Li, Xiaoyu; Wang, Zimei; Aizawa, Emi; Goebl, April; Soligalla, Rupa Devi; Reddy, Pradeep; Esteban, Concepcion Rodriguez; Tang, Fuchou; Liu, Guang-Hui; Belmonte, Juan Carlos Izpisua

    2015-06-05

    Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency. Here, we report on the generation of a human WS model in human embryonic stem cells (ESCs). Differentiation of WRN-null ESCs to mesenchymal stem cells (MSCs) recapitulates features of premature cellular aging, a global loss of H3K9me3, and changes in heterochromatin architecture. We show that WRN associates with heterochromatin proteins SUV39H1 and HP1α and nuclear lamina-heterochromatin anchoring protein LAP2β. Targeted knock-in of catalytically inactive SUV39H1 in wild-type MSCs recapitulates accelerated cellular senescence, resembling WRN-deficient MSCs. Moreover, decrease in WRN and heterochromatin marks are detected in MSCs from older individuals. Our observations uncover a role for WRN in maintaining heterochromatin stability and highlight heterochromatin disorganization as a potential determinant of human aging.

  12. A novel Werner Syndrome mutation: pharmacological treatment by read-through of nonsense mutations and epigenetic therapies

    Science.gov (United States)

    Agrelo, Ruben; Sutz, Miguel Arocena; Setien, Fernando; Aldunate, Fabian; Esteller, Manel; Da Costa, Valeria; Achenbach, Ricardo

    2015-01-01

    Werner Syndrome (WS) is a rare inherited disease characterized by premature aging and increased propensity for cancer. Mutations in the WRN gene can be of several types, including nonsense mutations, leading to a truncated protein form. WRN is a RecQ family member with both helicase and exonuclease activities, and it participates in several cell metabolic pathways, including DNA replication, DNA repair, and telomere maintenance. Here, we reported a novel homozygous WS mutation (c.3767 C > G) in 2 Argentinian brothers, which resulted in a stop codon and a truncated protein (p.S1256X). We also observed increased WRN promoter methylation in the cells of patients and decreased messenger WRN RNA (WRN mRNA) expression. Finally, we showed that the read-through of nonsense mutation pharmacologic treatment with both aminoglycosides (AGs) and ataluren (PTC-124) in these cells restores full-length protein expression and WRN functionality. PMID:25830902

  13. Thermal entanglement and teleportation of a thermally mixed entangled state of a Heisenberg chain through a Werner state

    Institute of Scientific and Technical Information of China (English)

    Huang Li-Yuan; Fang Mao-Fa

    2008-01-01

    The thermal entanglement and teleportation of a thermally mixed entangled state of a two-qubit Heisenberg XXX chain under the Dzyaloshinski-Moriya (DM) anisotropic antisymmetric interaction through a noisy quantum channel given by a Werner state is investigated. The dependences of the thermal entanglement of the teleported state on the DM coupling constant, the temperature and the entanglement of the noisy quantum channel are studied in detail for both the ferromagnetic and the antiferromagnetic cases. The result shows that a minimum entanglement of the noisy quantum channel must be provided in order to realize the entanglement teleportation. The values of fidelity of the teleported state are also studied for these two cases. It is found that under certain conditions, we can transfer an initial state with a better fidelity than that for any classical communication protocol.

  14. Personalized Medicine Across Disciplines and without Borders. Vural Özdemir speaks to Hannah Wilson, Commissioning Editor.

    Science.gov (United States)

    Özdemir, Vural

    Vural Özdemir began his career as a medical doctor in Turkey in 1990, as a scientist at the Faculty of Medicine, University of Toronto (ON, Canada), where he obtained his MSc and PhD in clinical pharmacology (1998), and subsequently completed a 4-year postdoctoral fellowship in personalized medicine with the late Werner Kalow, a founding pioneer in the field of pharmacogenetics. Özdemir contributed to the conception and development of the repeated drug administration (RDA) method as a novel way of measuring pharmacological heritability, pharmacogenetics of psychiatric drugs and studying the clinical role of CYP2D6 genetic variations for endogenous neurotransmitter metabolism in the human brain. Recognizing that scientific knowledge is a product of both technology and social systems that often remain unaccounted for (e.g., human values, distribution of power and human agency, immigration, racial disparities, socioeconomic class and equity), Özdemir discovered the literature in the field of science and technology studies, a rich scholarly enquiry that asks fundamental questions and challenges assumptions regarding the backstage of technoscience, situates technology within its political context and makes hitherto unseen connections that frame science in ways that enable robust, responsible and sustainable innovation. From 2008 to 2012, Özdemir was awarded a mid-career "science and society" fellowship in order to retool as independent faculty and senior scientist in science and technology studies (STS), conducting research on research and examining his own trade - pharmacogenetics science - as an insider on the outside. Recently, Özdemir was awarded senior career support from the Scientific and Tehnological Research Council of Turkey, is an Associate Professor of both Communications and Human Genetics at the Faculty of Communications and serves as an advisor to the Rector for International Technology and Innovation Policy, Gaziantep University in Turkey. He is

  15. It may be a wise decision from ‘Editor-in-Chief and Publisher of IJAV’

    Directory of Open Access Journals (Sweden)

    Murlimanju BV

    2011-03-01

    Full Text Available Dear Sir,I read your editorial article ‘New measures taken for a better IJAV’ [1] and it seems that you have taken a wise decision for following up of the journal. As Prof. Nayak opined [2], having a processing fee for publication may discourage many authors, but in order to maintain the publication expenditures, editorial office and handling of higher number of manuscripts, you might have taken these steps. Since IJAV is an open access electronic journal, getting subscription fees from the institutions and universities is not possible. The anatomical variants are commonly encountered in day to day practice and are submitted to the journals for publication. But this is not that often with the original communications and review articles. In view of this, it may be difficult to manage a journal like IJAV as it is the only journal exclusively [3] made for publishing anatomical variations and clinical anatomy case reports. Waiving the processing fee for the authors from poor countries and students is an encouragement from the editor. Regarding the decision to provide incentives for the peer reviewers, instead of providing the money; it may be more suitable to issue a certificate from the editorial board for reviewing the case. It may help to decrease the amount of processing charge paid by the author. It’s a good idea to restrict the number of authors since most of the other reputed journal editors have opined that the authorship criteria for the case report should be four or less than four.I am very happy that IJAV has published more than hundreds of case reports within a short span of years. The map overlay of web traffic of IJAV via Google Analytics [1], which is displayed in your article, is informative and I am proud that our country ‘India’ is on higher traffic [1]. It is obvious that the Editor-in-Chief and his team deserve a big salute [4] for the hard work and efforts in bringing out the third volume. Wish the journal a bright

  16. Wikipedia and medicine: quantifying readership, editors, and the significance of natural language.

    Science.gov (United States)

    Heilman, James M; West, Andrew G

    2015-03-04

    .5% (100/117) had a university education. Although Wikipedia has a considerable volume of multilingual medical content that is extensively read and well-referenced, the core group of editors that contribute and maintain that content is small and shrinking in size.

  17. Problems faced by editors of peer reviewed medical journals.

    Science.gov (United States)

    Jawaid, Shaukat A

    2004-01-01

    Forty-six medical and dental journals are published from Pakistan of which only 29 are currently recognized by the Pakistan Medical and Dental Council. Only a few are peer reviewed. Six are indexed in Medline while EMBASE Excerpta Medica and World Health Organization Index Medicus for Eastern Mediterranean Region cover others. Editors of the peer reviewed medical journals are faced with numerous problems, which relate to the authors. Some of these are: shortage of quality of manuscripts, poor quality of reviewers, problems with indexation in international indexing services particularly Medline, duplicate submission and authorship and lastly, financial problems. Patronage from the Pharma industry is the major source of revenue which itself has serious implications. Editing a medical journal is a very stressful job and the editors have to work under too many pressures. A lot of useful data is presented at medical conferences, but a vast majority of it remains unpublished for various reasons, which adversely affects the citation rate from scientists from the developing third world countries in the world of medical literature. A few lectures on medical writing and research methodology to final year medical students will expose them to the art of medical writing. Specialty organizations can be persuaded to have a session on medical writing at their conferences, which will be extremely helpful not only to the potential new authors but also others, thereby improving the quality of their manuscripts. In addition to regular seminars, workshops for authors, reviewers and training courses for editors, subscribing to local medical journals by healthcare professionals and libraries are some of the measures that will help improve the situation to a great extent.

  18. EDITORIAL: Greetings from the new Editor-in-Chief Greetings from the new Editor-in-Chief

    Science.gov (United States)

    Nielsch, Kornelius

    2012-01-01

    On 1 January 2012 I will be assuming the position of Editor-in-Chief of the journal Semiconductor Science and Technology (SST). I am flattered by the confidence expressed in my ability to carry out this challenging job and I will try hard to justify this confidence. The previous Editor-in-Chief, Laurens Molenkamp, University of Würzburg, Germany, has worked tirelessly for the last ten years and has done an excellent job for the journal. Everyone at the journal is profoundly grateful for his leadership and for his achievements In 2012 several new members will join the Editorial Board: Professor Deli Wang (University of California, San Diego) with considerable expertise in semiconductor nanowires, Professor Saskia Fischer (Humboldt University, Berlin, Germany) with a background in semiconductor quantum devices, and Professor Erwin Kessels (Eindhoven University of Technology, Netherlands) with extensive experience in plasma processing of thin films and gate oxides. In particular, I want to express my gratitude to Professor Israel Bar-Joseph (Weizmann Institute of Science, Israel) and Professor Maria Tamargo (The City College of New York, USA), who will leave next year and who have vigorously served the Editorial Board for years. The journal has recently introduced a fast-track option for manuscripts. This option is a high-quality, high-profile outlet for new and important research across all areas of semiconductor research. Authors can expect to receive referee reports in less than 20 days from submission. Once accepted, you can expect the articles to be online within two or three weeks from acceptance and to be published in print in less than a month. Furthermore, all fast-track communications published in 2011 will be free to read for ten years. More detailed information on fast-track publication can be found on the following webpage: http://iopscience.iop.org/0268-1242/page/Fast track communications It is encouraging to see that since the journal introduced pre

  19. Ignacio Doménech, editor y autor culinario

    OpenAIRE

    Simón Palmer, María del Carmen

    2012-01-01

    Ignacio Doménech simboliza la modernidad en la cocina española desde finales del siglo XIX. De formación europea, comprende la importancia de transmitir los conocimientos profesionales y lo hará de tres formas: la realización práctica de menús, la enseñanza, para lo que crea la primera escuela de cocina, y la edición de textos. Como editor mantendrá durante cuarenta años la revista El Gorro Blanco, al tiempo que publica gran cantidad de libros ilustrados por los mejores dibujan...

  20. Conflict of Interest for Editor: Sweet and Sad Choices

    OpenAIRE

    2009-01-01

    On June 4, 2009, I was elected Dean of the University of Split School of Medicine, to take office at October 1, 2009. Since the University of Split School of Medicine is one of the 4 owners of the Croatian Medical Journal (CMJ), I have found myself in an awkward position of becoming the owner of the journal I edit. To resolve this conflict of interest, I will take a leave of absence from the position of the editor during my service as the dean. The following is the sto...

  1. Ignacio Doménech, editor y autor culinario

    OpenAIRE

    Simón Palmer, María del Carmen

    2012-01-01

    Ignacio Doménech simboliza la modernidad en la cocina española desde finales del siglo XIX. De formación europea, comprende la importancia de transmitir los conocimientos profesionales y lo hará de tres formas: la realización práctica de menús, la enseñanza, para lo que crea la primera escuela de cocina, y la edición de textos. Como editor mantendrá durante cuarenta años la revista El Gorro Blanco, al tiempo que publica gran cantidad de libros ilustrados por los mejores dibujan...

  2. PROTOTIPE VIDEO EDITOR DENGAN MENGGUNAKAN DIRECT X DAN DIRECT SHOW

    Directory of Open Access Journals (Sweden)

    Djoni Haryadi Setiabudi

    2004-01-01

    Full Text Available Technology development had given people the chance to capture their memorable moments in video format. A high quality digital video is a result of a good editing process. Which in turn, arise the new need of an editor application. In accordance to the problem, here the process of making a simple application for video editing needs. The application development use the programming techniques often applied in multimedia applications, especially video. First part of the application will begin with the video file compression and decompression, then we'll step into the editing part of the digital video file. Furthermore, the application also equipped with the facilities needed for the editing processes. The application made with Microsoft Visual C++ with DirectX technology, particularly DirectShow. The application provides basic facilities that will help the editing process of a digital video file. The application will produce an AVI format file after the editing process is finished. Through the testing process of this application shows the ability of this application to do the 'cut' and 'insert' of video files in AVI, MPEG, MPG and DAT formats. The 'cut' and 'insert' process only can be done in static order. Further, the aplication also provide the effects facility for transition process in each clip. Lastly, the process of saving the new edited video file in AVI format from the application. Abstract in Bahasa Indonesia : Perkembangan teknologi memberi kesempatan masyarakat untuk mengabadikan saat - saat yang penting menggunakan video. Pembentukan video digital yang baik membutuhkan proses editing yang baik pula. Untuk melakukan proses editing video digital dibutuhkan program editor. Berdasarkan permasalahan diatas maka pada penelitian ini dibuat prototipe editor sederhana untuk video digital. Pembuatan aplikasi memakai teknik pemrograman di bidang multimedia, khususnya video. Perencanaan dalam pembuatan aplikasi tersebut dimulai dengan pembentukan

  3. [Bogdan Suchodolski--initiator and editor-in-chief of the publication History of Polish Science].

    Science.gov (United States)

    Kuźnicka, Barbara; Kuźnicki, Leszek

    2011-01-01

    Among numerous and distinguished author's and editorial works of Bogdan Suchodolski a particular value presents a publication in eight volumes entitled 'History of Polish Science' (including two biographical and bibliographic volumes), which was published in the years 1970-1992 on Professor's own initiative and edited by himself. This is the first synthesis of the history of science in Poland, from the beginning of the Middle Ages till the present time (to 1952). In the conception of the initiator and editor the work presents the development of scientific thought and achievements of the scholars in relation to national culture and in connexions with the trends in science in the world. 'History of Polish Science' is the work written by several dozen authors, representing different domains of the knowledge. Scientific, organizational and editorial patronate was possible by dint of History of Science and Technology Establishment of Polish Academy of Sciences (presently the Institute for the History of Science of Polish Academy of Sciences), which was managed by Bogdan Suchodolski.

  4. Transparent Model Transformation: Turning Your Favourite Model Editor into a Transformation Tool

    DEFF Research Database (Denmark)

    Acretoaie, Vlad; Störrle, Harald; Strüber, Daniel

    2015-01-01

    Current model transformation languages are supported by dedicated editors, often closely coupled to a single execution engine. We introduce Transparent Model Transformation, a paradigm enabling modelers to specify transformations using a familiar tool: their model editor. We also present VMTL......, the first transformation language implementing the principles of Transparent Model Transformation: syntax, environment, and execution transparency. VMTL works by weaving a transformation aspect into its host modeling language. We show how our implementation of VMTL turns any model editor into a flexible...

  5. Editors' welcome, PORTAL, Vol 6, No 2, July 2009

    Directory of Open Access Journals (Sweden)

    Paul Allatson

    2010-01-01

    Full Text Available ‘Post-Mao, Post-Bourdieu: Class and Taste in Contemporary China,’ is a special issue of PORTAL Journal of Multidisciplinary International Studies guest-edited by Yi Zheng (University of Sydney and Stephanie Hemelryk Donald (RMIT University. The special issue explores the relationship between taste, choice and social stratification in contemporary China, and includes a new section, ‘New Perspectives Reports,’ which is intended to showcase opinion and ideas—in this case from the People’s Republic of China, in Mandarin—that complement the main articles. We hope to include this section in future issues of the journal. The guest editors and the PORTAL editorial committee would like to acknowledge that this special issue of is a result of a funding grant from the Australian Research Council, 2003-2005: ‘The Making of Middle-Class Taste: Reading, Tourism, and Educational Choices in Urban China.’ I am also delighted to announce that the PORTAL Editorial Committee has three new members, all from the Faculty of Arts and Social Sciences at the University of Technology, Sydney: Dr Malcolm Angelucci, Dr Beatriz Carrillo, and Dr Fredericka van der Lubbe. Paul Allatson, Editor, PORTAL Journal of Multidisciplinary International Studies.

  6. Gene targeting, genome editing: from Dolly to editors.

    Science.gov (United States)

    Tan, Wenfang; Proudfoot, Chris; Lillico, Simon G; Whitelaw, C Bruce A

    2016-06-01

    One of the most powerful strategies to investigate biology we have as scientists, is the ability to transfer genetic material in a controlled and deliberate manner between organisms. When applied to livestock, applications worthy of commercial venture can be devised. Although initial methods used to generate transgenic livestock resulted in random transgene insertion, the development of SCNT technology enabled homologous recombination gene targeting strategies to be used in livestock. Much has been accomplished using this approach. However, now we have the ability to change a specific base in the genome without leaving any other DNA mark, with no need for a transgene. With the advent of the genome editors this is now possible and like other significant technological leaps, the result is an even greater diversity of possible applications. Indeed, in merely 5 years, these 'molecular scissors' have enabled the production of more than 300 differently edited pigs, cattle, sheep and goats. The advent of genome editors has brought genetic engineering of livestock to a position where industry, the public and politicians are all eager to see real use of genetically engineered livestock to address societal needs. Since the first transgenic livestock reported just over three decades ago the field of livestock biotechnology has come a long way-but the most exciting period is just starting.

  7. A Generic Metadata Editor Supporting System Using Drupal CMS

    Science.gov (United States)

    Pan, J.; Banks, N. G.; Leggott, M.

    2011-12-01

    Metadata handling is a key factor in preserving and reusing scientific data. In recent years, standardized structural metadata has become widely used in Geoscience communities. However, there exist many different standards in Geosciences, such as the current version of the Federal Geographic Data Committee's Content Standard for Digital Geospatial Metadata (FGDC CSDGM), the Ecological Markup Language (EML), the Geography Markup Language (GML), and the emerging ISO 19115 and related standards. In addition, there are many different subsets within the Geoscience subdomain such as the Biological Profile of the FGDC (CSDGM), or for geopolitical regions, such as the European Profile or the North American Profile in the ISO standards. It is therefore desirable to have a software foundation to support metadata creation and editing for multiple standards and profiles, without re-inventing the wheels. We have developed a software module as a generic, flexible software system to do just that: to facilitate the support for multiple metadata standards and profiles. The software consists of a set of modules for the Drupal Content Management System (CMS), with minimal inter-dependencies to other Drupal modules. There are two steps in using the system's metadata functions. First, an administrator can use the system to design a user form, based on an XML schema and its instances. The form definition is named and stored in the Drupal database as a XML blob content. Second, users in an editor role can then use the persisted XML definition to render an actual metadata entry form, for creating or editing a metadata record. Behind the scenes, the form definition XML is transformed into a PHP array, which is then rendered via Drupal Form API. When the form is submitted the posted values are used to modify a metadata record. Drupal hooks can be used to perform custom processing on metadata record before and after submission. It is trivial to store the metadata record as an actual XML file

  8. Letter to the Editor - responses to Weisntein D, Simon M, Yehezkel E, Laron Z, Werner H. Insulin analogues display IGF-I-like mitogenic and antiactivity in cultured cancer cells.

    Science.gov (United States)

    Weinstein, Doron; Simon, Meital; Yehezkel, Einat; Laron, Zvi; Werner, Haim

    2013-08-20

    We thank the team of Eli Lilly and Company for their critical appraisal of our study and for giving us the opportunity to clarify a number of points [1]. We agree with Kazda et al. that randomized clinical trials will best address any direct relationship between insulin analogues and cancer in man. We do not question the fact that tight control of blood glucose has dramatically advanced the lives of patients with diabetes. This article is protected by copyright. All rights reserved.

  9. The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells.

    Science.gov (United States)

    Bagley, Mark C; Dwyer, Jessica E; Baashen, Mohammed; Dix, Matthew C; Murziani, Paola G S; Rokicki, Michal J; Kipling, David; Davis, Terence

    2016-01-21

    Microwave-assisted synthesis of the pyrazolyl ketone p38 MAPK inhibitor RO3201195 in 7 steps and 15% overall yield, and the comparison of its effect upon the proliferation of Werner Syndrome cells with a library of pyrazolyl ketones, strengthens the evidence that p38 MAPK inhibition plays a critical role in modulating premature cellular senescence in this progeroid syndrome and the reversal of accelerated ageing observed in vitro on treatment with SB203580.

  10. Online Database Editor Design for Web Based Distance Education

    Directory of Open Access Journals (Sweden)

    Mustafa Ali Akça

    2015-10-01

    Full Text Available Web-Based Distance Education every day continues to increase its influence in all areas. Informatics, especially in software training is widely used in web-based distance education. However, based on coding in a course with topics of mutual teacher / student interaction, also known to increase the success of the individual is a fact. In this study, software engineering, computer engineering, computer teacher and information technology departments, such as computer programming course to be used in the online database to MSSQL editor is designed as an employee. In this study, students entering the system assigned to them can create tables in the database online, it can add data to the tables and SQL queries can be run. Students in all of these studies, despite all the distance education classroom environment facility engages in close communication facilities.

  11. Free editors and peers: squeezing the lemon dry

    Directory of Open Access Journals (Sweden)

    Teixeira da Silva Jaime A.

    2016-12-01

    Full Text Available In this opinion piece, some of the practices of academic publication in the biomedical field related to the rewarding, or the lack thereof, of peer reviewers are described and discussed. The role and possibly exploitative relationship of mainstream, established publishers of prestigious journals towards their contributors (authors, and peer reviewers is considered. In addition, the role and accountability of publishers and contributors in “predatory” journals is assessed. Professionals who are recruited by the publishing industry, especially the for-profit industry, either as peer reviewers or editors, to complete a professional task, should be rewarded financially as professionals, as for other sectors of the economy, and not simply exploited for free. Points systems or discounts off a publisher’s products do not constitute sufficient, or fair, compensation.

  12. Automatic adverse drug events detection using letters to the editor.

    Science.gov (United States)

    Yang, Chao; Srinivasan, Padmini; Polgreen, Philip M

    2012-01-01

    We present and test the intuition that letters to the editor in journals carry early signals of adverse drug events (ADEs). Surprisingly these letters have not yet been exploited for automatic ADE detection unlike for example, clinical records and PubMed. Part of the challenge is that it is not easy to access the full-text of letters (for the most part these do not appear in PubMed). Also letters are likely underrated in comparison with full articles. Besides demonstrating that this intuition holds we contribute techniques for post market drug surveillance. Specifically, we test an automatic approach for ADE detection from letters using off-the-shelf machine learning tools. We also involve natural language processing for feature definitions. Overall we achieve high accuracy in our experiments and our method also works well on a second new test set. Our results encourage us to further pursue this line of research.

  13. Horwitz starts term as EosSPA Editor

    Science.gov (United States)

    James L. Horwitz began his term as Eos section editor for Space Phyics and Aeronomy in January. He is professor of physics and associate director of the Center for Space Plasma and Aeronomic Research (CSPAR) at The University of Alabama in Huntsville. Horwitz obtained a B.A. in Physics with highest Honors from the University of California in San Diego in 1970. He received his M.S. and Ph.D. degrees from the same institution, in 1972 and 1976, respectively. His Ph.D. dissertation title was “Radar Measurements of Electric Fields in the High Latitude Ionosphere and Other Topics in Auroral Physics.” In 1976, Horwitz entered the NASA Marshall Space Flight Center as an NAS/NRC Research Associate, analyzing low-energy plasma data from instruments aboard the ATS-6 and ISEE-1 satellites.

  14. EPUB Editor. Autoproduzione di e-book come esperienza didattica.

    Directory of Open Access Journals (Sweden)

    Francesco Leonetti

    2014-08-01

    Full Text Available La sostanziale differenza tra book ed e-book è data dal fatto che nel libro cartaceo (book, il contenuto e il “dispositivo di lettura” sono integrati, mentre l’e-book distingue il contenuto (file dal dispositivo utilizzato per fruirlo. Oltre a ciò, la tecnologia digitale consente di esplorare forme espressive del tutto inedite rispetto alla carta, che non sono date solo dalla multimedialità e interattività, ma anche da aspetti funzionali dei dispositivi digitali e dello “status” digitale del contenuto per molti versi non ancora del tutto attuati ed implementati. Il formato EPUB, meglio di altri, consente di applicare queste peculiarità ad un e-book e di svilupparlo in modo semplice ed immediato tramite uno degli strumenti autore disponibili sul mercato, quale, ad esempio, EPUB Editor, un tool online particolarmente utilizzato in contesto scolastico e didattico, di cui vengono dati esempi di lavori realizzati.

  15. Advanced software development workstation project: Engineering scripting language. Graphical editor

    Science.gov (United States)

    1992-01-01

    Software development is widely considered to be a bottleneck in the development of complex systems, both in terms of development and in terms of maintenance of deployed systems. Cost of software development and maintenance can also be very high. One approach to reducing costs and relieving this bottleneck is increasing the reuse of software designs and software components. A method for achieving such reuse is a software parts composition system. Such a system consists of a language for modeling software parts and their interfaces, a catalog of existing parts, an editor for combining parts, and a code generator that takes a specification and generates code for that application in the target language. The Advanced Software Development Workstation is intended to be an expert system shell designed to provide the capabilities of a software part composition system.

  16. Quantifying national information interests using the activity of Wikipedia editors

    CERN Document Server

    Karimi, Fariba; Samoilenko, Ann; Rosvall, Martin; Lancichinetti, Andrea

    2015-01-01

    We live in a "global village" where electronic communication has eliminated the geographical barriers of information exchange. With global information exchange, the road is open to worldwide convergence of opinions and interests. However, it remains unknown to what extent interests actually have become global. To address how interests differ between countries, we analyze the information exchange in Wikipedia, the largest online collaborative encyclopedia. From the editing activity in Wikipedia, we extract the interest profiles of editors from different countries. Based on a statistical null model for interest profiles, we create a network of significant links between countries with similar interests. We show that countries are divided into 18 clusters with similar interest profiles in which language, geography, and historical background polarize the interests. Despite the opportunities of global communication, the results suggest that people nevertheless care about local information.

  17. Automatically assessing Wikipedia article quality by exploiting article-editor networks

    NARCIS (Netherlands)

    Li, X.; Tang, J.; Wang, T.; Luo, Z.; de Rijke, M.; Hanbury, A.; Kazai, G.; Rauber, A.; Fuhr, N.

    2015-01-01

    We consider the problem of automatically assessing Wikipedia article quality. We develop several models to rank articles by using the editing relations between articles and editors. First, we create a basic model by modeling the article-editor network. Then we design measures of an editor’s

  18. Adequacy of authors' replies to criticism raised in electronic letters to the editor: cohort study

    DEFF Research Database (Denmark)

    Gøtzsche, Peter C; Delamothe, Tony; Godlee, Fiona

    2010-01-01

    To investigate whether substantive criticism in electronic letters to the editor, defined as a problem that could invalidate the research or reduce its reliability, is adequately addressed by the authors.......To investigate whether substantive criticism in electronic letters to the editor, defined as a problem that could invalidate the research or reduce its reliability, is adequately addressed by the authors....

  19. Adolescent Sexual Initiation through the Lens of Letters to the Editor Published in Polish Teenage Magazines

    Science.gov (United States)

    Kopacz, Marek S.; Bajka-Kopacz, Aleksandra

    2012-01-01

    Almost all teenage magazines invite readers to submit questions concerning relationships, published as letters to the editor, popularly called "advice columns," often containing explicit questions about sexuality. This study aims to examine, firstly, how themes related to sexual initiation are presented in letters to the editor published in Polish…

  20. Adolescent Sexual Initiation through the Lens of Letters to the Editor Published in Polish Teenage Magazines

    Science.gov (United States)

    Kopacz, Marek S.; Bajka-Kopacz, Aleksandra

    2012-01-01

    Almost all teenage magazines invite readers to submit questions concerning relationships, published as letters to the editor, popularly called "advice columns," often containing explicit questions about sexuality. This study aims to examine, firstly, how themes related to sexual initiation are presented in letters to the editor published…

  1. Beacon Editor: Capturing Signal Transduction Pathways Using the Systems Biology Graphical Notation Activity Flow Language.

    Science.gov (United States)

    Elmarakeby, Haitham; Arefiyan, Mostafa; Myers, Elijah; Li, Song; Grene, Ruth; Heath, Lenwood S

    2017-08-28

    The Beacon Editor is a cross-platform desktop application for the creation and modification of signal transduction pathways using the Systems Biology Graphical Notation Activity Flow (SBGN-AF) language. Prompted by biologists' requests for enhancements, the Beacon Editor includes numerous powerful features for the benefit of creation and presentation.

  2. Magazine Article Placement: How Editors, Regular Contributors, and Novice Writers Rate Query Letters.

    Science.gov (United States)

    Jolliffe, Lee

    About 350,000 freelance magazine articles were purchased by magazine editors last year from the 22,000 freelancers and 225,000 would-be freelancers in the United States. A study examined the factors editors judge most important in selecting freelance magazine article proposals, using factor analysis and qualitative examination of persuasive…

  3. Self-Interest and Scholarly Publication: The Dilemma of Researchers, Reviewers, and Editors

    Science.gov (United States)

    Calabrese, Raymond L.; Roberts, Brian

    2004-01-01

    Academic misconduct in research is of growing concern to funding agencies, scholars, and academic journal editors. Scholarly publication has ethical implications researchers, reviewers, and journal editors. The theoretical background of the ethics of scholarly publication is explored as well as the use of a case study of an untenured researcher…

  4. "Clones," Codes, and Conflicts of Interest in Cartooning: Cartoonists and Editors Look at Ethics.

    Science.gov (United States)

    Riffe, Daniel; And Others

    A study examined differences between political cartoonists and op-ed page editors on both traditional ethical issues (such as conflicts of interest) and the special, style-related concerns of editorial cartoonists. Hypotheses proposed were that editors and cartoonists (1) would condemn "cloning" or copying, reflecting an ethical…

  5. Magazine Article Placement: How Editors, Regular Contributors, and Novice Writers Rate Query Letters.

    Science.gov (United States)

    Jolliffe, Lee

    About 350,000 freelance magazine articles were purchased by magazine editors last year from the 22,000 freelancers and 225,000 would-be freelancers in the United States. A study examined the factors editors judge most important in selecting freelance magazine article proposals, using factor analysis and qualitative examination of persuasive…

  6. Appropriate Roles for the Subscriber, Publisher, Editor, Author, and Reviewer in the Archives of Plastic Surgery

    Directory of Open Access Journals (Sweden)

    Kun Hwang

    2013-11-01

    Full Text Available Authors, editors and reviewers, publishers, and subscribers all play their role in scientific journals. These 5 stakeholders are essential to journals. In this paper, firstly, I briefly summarize the role of each journal stakeholder and their respective goals. Secondly, the status of each participant in the Archives of Plastic Surgery is described. Finally, I propose an appropriate role and plan for each of them. Specific roles and responsibilities include the following: subscribers should welcome and submit the critiques of published papers in letters to the editor. Publishers should trust editors and provide them with adequate financial support for ongoing quality improvement of the journal. The editor-in-chief should be given a sufficient period of time-several years-to build up journal quality and train the incoming editor. The editors, including section editors, are also responsible for increasing the author pool. One editor might be designated a 'devil's referee', that is, a kind of devil's advocate with the responsibility of examining the originality of the manuscript, taking a skeptical view of the manuscript, and looking for holes in the methods and results of reported experiments. Authors' responsibilities include submitting manuscripts with scientific integrity and being ready to take responsibility for their articles even long after publication. Finally, reviewers' responsibilities include identifying similar articles not cited. Reviewers are also welcome to write a discussion on the article they review.

  7. Adolescent Sexual Initiation through the Lens of Letters to the Editor Published in Polish Teenage Magazines

    Science.gov (United States)

    Kopacz, Marek S.; Bajka-Kopacz, Aleksandra

    2012-01-01

    Almost all teenage magazines invite readers to submit questions concerning relationships, published as letters to the editor, popularly called "advice columns," often containing explicit questions about sexuality. This study aims to examine, firstly, how themes related to sexual initiation are presented in letters to the editor published…

  8. Chief Editor: Michael H. Schleyer Volume 13, Issue 1 Jan - June 2014

    African Journals Online (AJOL)

    The journal will, from time to time, consist of special issues on major events or important ... Within an estuary and near a river mouth, transport in the ...... weather, lower salinities and higher plankton ...... shows the cyclical peaks within the time series (period in days) of larvae confirmed by the Autocorrelation. Function plot ...

  9. Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2.

    Science.gov (United States)

    Edwards, Deanna N; Orren, David K; Machwe, Amrita

    2014-07-01

    Werner syndrome (WS), caused by loss of function of the RecQ helicase WRN, is a hereditary disease characterized by premature aging and elevated cancer incidence. WRN has DNA binding, exonuclease, ATPase, helicase and strand annealing activities, suggesting possible roles in recombination-related processes. Evidence indicates that WRN deficiency causes telomeric abnormalities that likely underlie early onset of aging phenotypes in WS. Furthermore, TRF2, a protein essential for telomere protection, interacts with WRN and influences its basic helicase and exonuclease activities. However, these studies provided little insight into WRN's specific function at telomeres. Here, we explored the possibility that WRN and TRF2 cooperate during telomeric recombination processes. Our results indicate that TRF2, through its interactions with both WRN and telomeric DNA, stimulates WRN-mediated strand exchange specifically between telomeric substrates; TRF2's basic domain is particularly important for this stimulation. Although TRF1 binds telomeric DNA with similar affinity, it has minimal effects on WRN-mediated strand exchange of telomeric DNA. Moreover, TRF2 is displaced from telomeric DNA by WRN, independent of its ATPase and helicase activities. Together, these results suggest that TRF2 and WRN act coordinately during telomeric recombination processes, consistent with certain telomeric abnormalities associated with alteration of WRN function.

  10. The Direct Collapse of a Massive Black Hole Seed Under the Influence of an Anisotropic Lyman-Werner Source

    CERN Document Server

    Regan, John A; Wise, John H

    2014-01-01

    The direct collapse model of supermassive black hole seed formation provides an attractive solution to the origin of the quasars now routinely observed at $z \\gtrsim 6$. We use the adaptive mesh refinement code Enzo to simulate the collapse of gas at high redshift, including a nine species chemical model of H, He, and H$_2$. The direct collapse model requires that the gas cools predominantly via atomic hydrogen. To this end we simulate the effect of an anisotropic radiation source on the collapse of a halo at high redshift. The radiation source is placed at a distance of 3 kpc (physical) from the collapsing object. The source is set to emit monochromatically in the center of the Lyman-Werner (LW) band only at $12.8 \\ \\rm{eV}$. The LW radiation emitted from the high redshift source is followed self-consistently using ray tracing techniques. We find that, due to self-shielding, a small amount of H$_2$ is able to form at the very center of the collapsing halo even under very strong LW radiation. Furthermore, we ...

  11. The Direct Collapse of a Massive Black Hole Seed under the Influence of an Anisotropic Lyman-Werner Source

    Science.gov (United States)

    Regan, John A.; Johansson, Peter H.; Wise, John H.

    2014-11-01

    The direct collapse model of supermassive black hole seed formation requires that the gas cools predominantly via atomic hydrogen. To this end we simulate the effect of an anisotropic radiation source on the collapse of a halo at high redshift. The radiation source is placed at a distance of 3 kpc (physical) from the collapsing object and is set to emit monochromatically in the center of the Lyman-Werner (LW) band. The LW radiation emitted from the high redshift source is followed self-consistently using ray tracing techniques. Due to self-shielding, a small amount of H2 is able to form at the very center of the collapsing halo even under very strong LW radiation. Furthermore, we find that a radiation source, emitting >1054 (~ 103 J21) photons s-1, is required to cause the collapse of a clump of M ~ 105 M ⊙. The resulting accretion rate onto the collapsing object is ~0.25 M ⊙ yr-1. Our results display significant differences, compared to the isotropic radiation field case, in terms of the H2 fraction at an equivalent radius. These differences will significantly affect the dynamics of the collapse. With the inclusion of a strong anisotropic radiation source, the final mass of the collapsing object is found to be M ~ 105 M ⊙. This is consistent with predictions for the formation of a supermassive star or quasi-star leading to a supermassive black hole.

  12. Differential expression of Werner and Bloom syndrome genes in the peripheral blood of HIV-1 infected patients.

    Science.gov (United States)

    Bordi, Licia; Gioia, Cristiana; Lalle, Eleonora; Piselli, Pierluca; Poccia, Fabrizio; Capobianchi, Maria R; Amendola, Alessandra

    2007-02-01

    Human immunodeficiency virus (HIV)-induced immunodeficiency and immune-system aging share some analogies. Since Werner (WRN) and Bloom (BLM) helicases are crucial in cell repair and aging, their peripheral blood mononuclear cells (PBMC) mRNA levels were compared in HIV-1 infected patients and in normal donors. The mean levels of WRN mRNA were 3.7-fold higher in PBMCs from HIV-1 infected individuals in comparison to healthy donors, whereas BLM mRNA mean levels were slightly higher, although not significantly. WRN increase was positively correlated to CD4 and CD8 T-cell numbers, and also the percentage of naive T lymphocytes, and was observed also in T-cell subsets. Interestingly, a general trend toward increased WRN mRNA levels in individuals with lower viral load was observed, without association with patient age, time of seroconversion, and on/off antiretroviral therapy regimen. On the whole, this study shows that WRN and BLM are differentially modulated in HIV infection, as WRN--but not BLM--is significantly increased, suggesting that mechanisms different from defect or loss of helicase function, observed in WRN and BLM syndromes, may be at the basis of T-cell aging in HIV infection.

  13. F. Oliver Brachfeld y Werner Wolff: dos figuras en los inicios de la Sociedad Interamericana de Psicología

    Directory of Open Access Journals (Sweden)

    Ramón León

    2012-01-01

    Full Text Available F. Oliver Brachfeld (1908-1967 y Werner Wolff (1904-1957 fueron dos psicólogos europeos emigrados a América del Sur (Brachfeld y a los Estados Unidos de Norteamérica (Wolff que desempeñaron importantes funciones en los años iniciales de la Sociedad Interamericana de Psicología (SIP. Brachfeld fue su Presidente entre 1953 y 1955, en tanto que Wolff fue uno de los gestores de su creación (al lado de Oswaldo Robles, Guillermo Dávila y Rogelio Díaz-Guerrero, su primer Vicepresidente entre 1951 y 1953 y su Secretario General desde 1953 hasta 1957, el año de su prematura muerte. A pesar de su participación en la SIP y de su activo trabajo científico, expresado en obras como Introducción a la psicología e Introducción a la psicopatología, de Wolff, y, Los sentimientos de inferioridad, de Brachfeld, hoy ambos están casi olvidados. La presente comunicación hace una breve reseña biográfica de uno y otro, y analiza las razones por las cuales en la actualidad se habla muy poco de ambos.

  14. Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase.

    Science.gov (United States)

    Nora, Gerald J; Buncher, Noah A; Opresko, Patricia L

    2010-07-01

    WRN protein loss causes Werner syndrome (WS), which is characterized by premature aging as well as genomic and telomeric instability. WRN prevents telomere loss, but the telomeric protein complex must regulate WRN activities to prevent aberrant telomere processing. Telomere-binding TRF2 protein inhibits telomere t-loop deletion by blocking Holliday junction (HJ) resolvase cleavage activity, but whether TRF2 also modulates HJ displacement at t-loops is unknown. In this study, we used multiplex fluorophore imaging to track the fate of individual strands of HJ substrates. We report the novel finding that TRF2 inhibits WRN helicase strand displacement of HJs with telomeric repeats in duplex arms, but unwinding of HJs with a telomeric center or lacking telomeric sequence is unaffected. These data, together with results using TRF2 fragments and TRF2 HJ binding assays, indicate that both the TRF2 B- and Myb domains are required to inhibit WRN HJ activity. We propose a novel model whereby simultaneous binding of the TRF2 B-domain to the HJ core and the Myb domain to telomeric arms promote and stabilize HJs in a stacked arm conformation that is unfavorable for unwinding. Our biochemical study provides a mechanistic basis for the cellular findings that TRF2 regulates WRN activity at telomeres.

  15. Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase.

    Science.gov (United States)

    Aumailley, Lucie; Dubois, Marie Julie; Garand, Chantal; Marette, André; Lebel, Michel

    2015-12-01

    Werner syndrome (WS) is a premature aging disorder caused by mutations in a DNA helicase/exonuclease. Mice lacking the helicase domain of this protein exhibit metabolic abnormalities that are reversed by vitamin C. In this study, we used a targeted metabolomic approach to identify serum metabolites significantly altered in young mutant mice treated with or without vitamin C. We also measured several serum inflammatory and cardiometabolic factors. We show that young mutant mice exhibit an increase in serum hydroxyproline and plasminogen activator inhibitor-1 (PAI-1), markers of cardiovascular diseases and inflammation, before they exhibit morphological anomalies in different tissues. We also observed an increase in three very long chain lysophosphatidylcholines underlying peroxisome perturbation. Vitamin C reversed the concentrations of these metabolites and PAI-1 to wild type values. Transcriptomic analyses on the liver of mutant mice revealed a decrease in the expression of genes involved in fatty acid degradation compared to wild type animals. Vitamin C treatment increased the expression of genes involved in glutathione metabolism and the synthesis of unsaturated fatty acids in these mice. These results show that changes at the transcriptomic level concord with the alterations of several serum metabolites in these mice. Finally, we found that a mislocalization of the Wrn mutant protein in the liver endoplasmic reticulum fraction increased oxidative stress in that cellular compartment. Vitamin C reversed this oxidative stress. To conclude, this study provides novel potential predictive cardiometabolic biomarkers in WS that will allow the assessment of the impact of vitamin C on patients with WS.

  16. Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture.

    Directory of Open Access Journals (Sweden)

    Akira Shimamoto

    Full Text Available Werner syndrome (WS is a premature aging disorder characterized by chromosomal instability and cancer predisposition. Mutations in WRN are responsible for the disease and cause telomere dysfunction, resulting in accelerated aging. Recent studies have revealed that cells from WS patients can be successfully reprogrammed into induced pluripotent stem cells (iPSCs. In the present study, we describe the effects of long-term culture on WS iPSCs, which acquired and maintained infinite proliferative potential for self-renewal over 2 years. After long-term cultures, WS iPSCs exhibited stable undifferentiated states and differentiation capacity, and premature upregulation of senescence-associated genes in WS cells was completely suppressed in WS iPSCs despite WRN deficiency. WS iPSCs also showed recapitulation of the phenotypes during differentiation. Furthermore, karyotype analysis indicated that WS iPSCs were stable, and half of the descendant clones had chromosomal profiles that were similar to those of parental cells. These unexpected properties might be achieved by induced expression of endogenous telomerase gene during reprogramming, which trigger telomerase reactivation leading to suppression of both replicative senescence and telomere dysfunction in WS cells. These findings demonstrated that reprogramming suppressed premature senescence phenotypes in WS cells and WS iPSCs could lead to chromosomal stability over the long term. WS iPSCs will provide opportunities to identify affected lineages in WS and to develop a new strategy for the treatment of WS.

  17. Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue.

    Science.gov (United States)

    Lebel, Michel

    2002-01-01

    Werner syndrome (WS) is a rare autosomal recessive disorder characterized by genomic instability and the premature onset of a number of age-related diseases, including cancers. Accumulating evidence indicates that the WS gene product is involved in resolving aberrant DNA structures that may arise during the process of DNA replication and/or transcription. To estimate the frequency of DNA deletions directly in the skin of mouse embryos, mice with a deletion of part of the murine WRN helicase domain were created. These mutant mice were then crossed to the pink-eyed unstable animals, which have a 70 kb internal duplication at the pink-eyed dilution (p) gene. This report indicates that the frequency of deletion of the duplicated sequence at the p locus is elevated in mice with a mutation in the WRN allele when compared with wild-type mice. In addition, the inhibitor of topoisomerase I camptothecin also increases the frequency of deletion at the p locus. This frequency is even more elevated in WRN mutant mice treated with camptothecin. In contrast, while the inhibition of poly(ADP-ribose) polymerase (PARP) activity by 3-aminobenzamide increases the frequency of DNA deletion, mutant WRN mice are not significantly more sensitive to the inhibition of PARP activity than wild-type animals.

  18. THE NEW ONLINE METADATA EDITOR FOR GENERATING STRUCTURED METADATA

    Energy Technology Data Exchange (ETDEWEB)

    Devarakonda, Ranjeet [ORNL; Shrestha, Biva [ORNL; Palanisamy, Giri [ORNL; Hook, Leslie A [ORNL; Killeffer, Terri S [ORNL; Boden, Thomas A [ORNL; Cook, Robert B [ORNL; Zolly, Lisa [United States Geological Service (USGS); Hutchison, Viv [United States Geological Service (USGS); Frame, Mike [United States Geological Service (USGS); Cialella, Alice [Brookhaven National Laboratory (BNL); Lazer, Kathy [Brookhaven National Laboratory (BNL)

    2014-01-01

    Nobody is better suited to describe data than the scientist who created it. This description about a data is called Metadata. In general terms, Metadata represents the who, what, when, where, why and how of the dataset [1]. eXtensible Markup Language (XML) is the preferred output format for metadata, as it makes it portable and, more importantly, suitable for system discoverability. The newly developed ORNL Metadata Editor (OME) is a Web-based tool that allows users to create and maintain XML files containing key information, or metadata, about the research. Metadata include information about the specific projects, parameters, time periods, and locations associated with the data. Such information helps put the research findings in context. In addition, the metadata produced using OME will allow other researchers to find these data via Metadata clearinghouses like Mercury [2][4]. OME is part of ORNL s Mercury software fleet [2][3]. It was jointly developed to support projects funded by the United States Geological Survey (USGS), U.S. Department of Energy (DOE), National Aeronautics and Space Administration (NASA) and National Oceanic and Atmospheric Administration (NOAA). OME s architecture provides a customizable interface to support project-specific requirements. Using this new architecture, the ORNL team developed OME instances for USGS s Core Science Analytics, Synthesis, and Libraries (CSAS&L), DOE s Next Generation Ecosystem Experiments (NGEE) and Atmospheric Radiation Measurement (ARM) Program, and the international Surface Ocean Carbon Dioxide ATlas (SOCAT). Researchers simply use the ORNL Metadata Editor to enter relevant metadata into a Web-based form. From the information on the form, the Metadata Editor can create an XML file on the server that the editor is installed or to the user s personal computer. Researchers can also use the ORNL Metadata Editor to modify existing XML metadata files. As an example, an NGEE Arctic scientist use OME to register

  19. The Best Stylists: A Survey of Editors, and Implications for the Teaching of Style in Freshman Composition Courses.

    Science.gov (United States)

    Spigelmire, Lynne

    A survey of 112 editors from magazines, newspapers, and publishing houses was conducted to obtain their judgments about prose style, the best prose stylists, and representative works by those stylists. Of the 112 editors surveyed, only 22 responded with useful data. The results indicated very little consensus among editors, and almost no…

  20. Editors' Introduction: New Perspectives on 'The War-Prayer'

    Directory of Open Access Journals (Sweden)

    Shelley Fisher Fishkin

    2009-02-01

    Full Text Available

    "The War-Prayer," written a hundred years ago as Mark Twain reflected on the conditions surrounding the U.S. decision to embark on the imperialist venture known as the Philippine-American War, speaks to us across time in strikingly uncanny ways. Although today "The War-Prayer" is increasingly accessible to readers worldwide, this important piece by Mark Twain has never received the critical attention that it warrants. Neither has it occupied the place that it deserves in the Mark Twain canon, or in the American literary canon. In the years since its first publication in 1923, it has often been reprinted. But it rarely appears in anthologies of American literature, and it is among the least well-known works by Twain as far as the general public is concerned. Indeed, educated individuals are often startled and shocked when they are introduced to this piece, dumbfounded as to why they never encountered it before. A question worth pondering: How might American history and world history in the 20th century have been different if "The War-Prayer" had been as familiar to every high school student as Tom Sawyer? As editors of this international forum on "The War-Prayer" in Mark Twain Studies, we are pleased to be able to give this important work by Mark Twain some of the attention that it has long deserved.

  1. Editors' Introduction: New Perspectives on 'The War-Prayer'

    Directory of Open Access Journals (Sweden)

    Shelley Fisher Fishkin

    2009-02-01

    Full Text Available "The War-Prayer," written a hundred years ago as Mark Twain reflected on the conditions surrounding the U.S. decision to embark on the imperialist venture known as the Philippine-American War, speaks to us across time in strikingly uncanny ways. Although today "The War-Prayer" is increasingly accessible to readers worldwide, this important piece by Mark Twain has never received the critical attention that it warrants. Neither has it occupied the place that it deserves in the Mark Twain canon, or in the American literary canon. In the years since its first publication in 1923, it has often been reprinted. But it rarely appears in anthologies of American literature, and it is among the least well-known works by Twain as far as the general public is concerned. Indeed, educated individuals are often startled and shocked when they are introduced to this piece, dumbfounded as to why they never encountered it before. A question worth pondering: How might American history and world history in the 20th century have been different if "The War-Prayer" had been as familiar to every high school student as Tom Sawyer? As editors of this international forum on "The War-Prayer" in Mark Twain Studies, we are pleased to be able to give this important work by Mark Twain some of the attention that it has long deserved.

  2. Misunderstanding publication bias: editors are not blameless after all.

    Science.gov (United States)

    Senn, Stephen

    2012-01-01

    In analysing whether there is an editorial bias in favour of positive studies, researchers have made implicit assumptions that are implausible. In particular, to justify the conclusion that there is no bias because observed editorial acceptance rates do not favour positive studies, the assumption that the decision to submit an article is based solely on quality would be required. If, on the other hand, submission were based on perceived probability of acceptance, negative and positive studies would not differ in terms of acceptance rates, but in terms of quality. It is shown, using a simple graphical model, how similar underlying situations as regards the relationship between quality and probability of acceptance on the one hand and study outcome (positive or negative) and probability of acceptance on the other could produce dramatically different results depending on the behaviour of authors. Furthermore, there is, in fact, some evidence that submitted negative studies are, on average, of higher quality than positive ones. This calls into question the standard interpretation of the studies examining editorial bias. It would appear that despite similar probabilities of acceptance for negative and positive studies, editors could be discriminating against negative studies.

  3. BOOK REVIEW - PHILIP MCCANN (EDITOR, INDUSTRIAL LOCATION ECONOMICS

    Directory of Open Access Journals (Sweden)

    Daniela L. Constantin

    2005-07-01

    Full Text Available The book Industrial Location Economics published by Edward Elgar Publishing Limited is a highly relevant example in this respect. The Editor, Professor Philip McCann from the University of Reading, UK, a brilliant representative of the new generation of regional scientists, has succeeded in attracting around this subject internationally renowned scholars belonging to top universities form Austria, the Netherlands, UK, Italy, Canada, USA and Japan. They address a variety of topics concentrating on the spatial behaviour of individual firms and the growth and generation of industrial clusters and cities, offering an original, comparison and contrast-based combination of classical and more recent approaches to location analysis. A wide range of analytical techniques is employed – some of them being the authors’ contribution to enriching the investigation methodology of industrial location, that has made it possible to address the same issues from exciting, original perspectives. The excellent combination between theoretical knowledge and empirical testing, between traditional and modern approaches to industrial location economics as well as the clarity of the ideas expressed recommend this worthwhile book to both academics and students in geography, economics, management as well as to experts in institutions involved in regional and urban planning.

  4. Geoyasgui: the Geosparql Query Editor and Result Set Visualizer

    Science.gov (United States)

    Beek, W.; Folmer, E.; Rietveld, L.; Walker, J.

    2017-07-01

    The Netherlands' Cadastre, Land Registry and Mapping Agency - in short Kadaster - collects and registers administrative and spatial data on property and the rights involved. This includes for ships, aircraft and telecommunications networks. Doing so, Kadaster protects legal certainty. The Kadaster publishes many large authoritative datasets including several key registers of the Dutch Government (Topography, Addresses and Buildings). Furthermore Kadaster is also developing and maintaining the PDOK shared service, in which about 100 spatial datasets are being published in several formats, including an incredible amount of detailed geospatial objects. Geospatial objects include all plots of land, all buildings, all roads and all lampposts. These objects are spatially and/or conceptually related, but are maintained by different data curators. As a result these datasets are syntactically and architecturally disjoint, and using them together currently requires non-trivial human labor. In response to this, Kadaster is currently publishing its geo-spatial data assets as Linked Open Data. The standardized query language for Linked Open Geodata is GeoSPARQL. Unfortunately, current tooling does not support writing and evaluating GeoSPARQL queries. This paper presents GeoYASGUI, a GeoSPARQL editor and result-set viewer with IDE capabilities. GeoYASGUI is not a new software product, but an integration of and a collection of updates to existing Open Source libraries. With GeoYASGUI it becomes possible to query the rich Open Data assets of the Kadaster.

  5. The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks.

    Science.gov (United States)

    Machwe, Amrita; Karale, Rajashree; Xu, Xioahua; Liu, Yilun; Orren, David K

    2011-08-16

    Cells cope with blockage of replication fork progression in a manner that allows DNA synthesis to be completed and genomic instability minimized. Models for resolution of blocked replication involve fork regression to form Holliday junction structures. The human RecQ helicases WRN and BLM (deficient in Werner and Bloom syndromes, respectively) are critical for maintaining genomic stability and thought to function in accurate resolution of replication blockage. Consistent with this notion, WRN and BLM localize to sites of blocked replication after certain DNA-damaging treatments and exhibit enhanced activity on replication and recombination intermediates. Here we examine the actions of WRN and BLM on a special Holliday junction substrate reflective of a regressed replication fork. Our results demonstrate that, in reactions requiring ATP hydrolysis, both WRN and BLM convert this Holliday junction substrate primarily to a four-stranded replication fork structure, suggesting they target the Holliday junction to initiate branch migration. In agreement, the Holliday junction binding protein RuvA inhibits the WRN- and BLM-mediated conversion reactions. Importantly, this conversion product is suitable for replication with its leading daughter strand readily extended by DNA polymerases. Furthermore, binding to and conversion of this Holliday junction are optimal at low MgCl(2) concentrations, suggesting that WRN and BLM preferentially act on the square planar (open) conformation of Holliday junctions. Our findings suggest that, subsequent to fork regression events, WRN and/or BLM could re-establish functional replication forks to help overcome fork blockage. Such a function is highly consistent with phenotypes associated with WRN- and BLM-deficient cells.

  6. Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice.

    Science.gov (United States)

    Aumailley, Lucie; Garand, Chantal; Dubois, Marie Julie; Johnson, F Brad; Marette, André; Lebel, Michel

    2015-01-01

    Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-family DNA helicase, WRN. Mice lacking part of the helicase domain of the WRN orthologue exhibit many phenotypic features of WS, including metabolic abnormalities and a shorter mean life span. In contrast, mice lacking the entire Wrn protein (i.e. Wrn null mice) do not exhibit a premature aging phenotype. In this study, we used a targeted mass spectrometry-based metabolomic approach to identify serum metabolites that are differentially altered in young Wrn helicase mutant and Wrn null mice. An antibody-based quantification of 43 serum cytokines and markers of cardiovascular disease risk complemented this study. We found that Wrn helicase mutants exhibited elevated and decreased levels, respectively, of the anti-inflammatory cytokine IL-10 and the pro-inflammatory cytokine IL-18. Wrn helicase mutants also exhibited an increase in serum hydroxyproline and plasminogen activator inhibitor-1, markers of extracellular matrix remodeling of the vascular system and inflammation in aging. We also observed an abnormal increase in the ratio of very long chain to short chain lysophosphatidylcholines in the Wrn helicase mutants underlying a peroxisome perturbation in these mice. Remarkably, the Wrn mutant helicase protein was mislocalized to the endoplasmic reticulum and the peroxisomal fractions in liver tissues. Additional analyses with mouse embryonic fibroblasts indicated a severe defect of the autophagy flux in cells derived from Wrn helicase mutants compared to wild type and Wrn null animals. These results indicate that the deleterious effects of the helicase-deficient Wrn protein are mediated by the dysfunction of several cellular organelles.

  7. Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice.

    Directory of Open Access Journals (Sweden)

    Lucie Aumailley

    Full Text Available Werner syndrome (WS is a premature aging disorder caused by mutations in a RecQ-family DNA helicase, WRN. Mice lacking part of the helicase domain of the WRN orthologue exhibit many phenotypic features of WS, including metabolic abnormalities and a shorter mean life span. In contrast, mice lacking the entire Wrn protein (i.e. Wrn null mice do not exhibit a premature aging phenotype. In this study, we used a targeted mass spectrometry-based metabolomic approach to identify serum metabolites that are differentially altered in young Wrn helicase mutant and Wrn null mice. An antibody-based quantification of 43 serum cytokines and markers of cardiovascular disease risk complemented this study. We found that Wrn helicase mutants exhibited elevated and decreased levels, respectively, of the anti-inflammatory cytokine IL-10 and the pro-inflammatory cytokine IL-18. Wrn helicase mutants also exhibited an increase in serum hydroxyproline and plasminogen activator inhibitor-1, markers of extracellular matrix remodeling of the vascular system and inflammation in aging. We also observed an abnormal increase in the ratio of very long chain to short chain lysophosphatidylcholines in the Wrn helicase mutants underlying a peroxisome perturbation in these mice. Remarkably, the Wrn mutant helicase protein was mislocalized to the endoplasmic reticulum and the peroxisomal fractions in liver tissues. Additional analyses with mouse embryonic fibroblasts indicated a severe defect of the autophagy flux in cells derived from Wrn helicase mutants compared to wild type and Wrn null animals. These results indicate that the deleterious effects of the helicase-deficient Wrn protein are mediated by the dysfunction of several cellular organelles.

  8. The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Trego, Kelly S.; Chernikova, Sophia B.; Davalos, Albert R.; Perry, J. Jefferson P.; Finger, L. David; Ng, Cliff; Tsai, Miaw-Sheue; Yannone, Steven M.; Tainer, John A.; Campisi, Judith; Cooper, Priscilla K.

    2011-04-20

    XPG is a structure-specific endonuclease required for nucleotide excision repair (NER). XPG incision defects result in the cancer-prone syndrome xeroderma pigmentosum, whereas truncating mutations of XPG cause the severe postnatal progeroid developmental disorder Cockayne syndrome. We show that XPG interacts directly with WRN protein, which is defective in the premature aging disorder Werner syndrome, and that the two proteins undergo similar sub-nuclear redistribution in S-phase and co-localize in nuclear foci. The co-localization was observed in mid- to late-S-phase, when WRN moves from nucleoli to nuclear foci that have been shown to contain protein markers of both stalled replication forks and telomeric proteins. We mapped the interaction between XPG and WRN to the C-terminal domains of each and show that interaction with the C-terminal domain of XPG strongly stimulates WRN helicase activity. WRN also possesses a competing DNA single-strand annealing activity that, combined with unwinding, has been shown to coordinate regression of model replication forks to form Holliday junction/chicken foot intermediate structures. We tested whether XPG stimulated WRN annealing activity and found that XPG itself has intrinsic strand annealing activity that requires the unstructured R- and C-terminal domains, but not the conserved catalytic core or endonuclease activity. Annealing by XPG is cooperative, rather than additive, with WRN annealing. Taken together, our results suggest a novel function for XPG in S-phase that is at least in part carried out coordinately with WRN, and which may contribute to the severity of the phenotypes that occur upon loss of XPG.

  9. Data Sharing: A New Editorial Initiative of the International Committee of Medical Journal Editors. Implications for the Editors´ Network.

    Science.gov (United States)

    Alfonso, Fernando; Adamyan, Karlen; Artigou, Jean-Yves; Aschermann, Michael; Boehm, Michael; Buendia, Alfonso; Chu, Pao-Hsien; Cohen, Ariel; Cas, Livio Dei; Dilic, Mirza; Doubell, Anton; Echeverri, Dario; Enç, Nuray; Ferreira-González, Ignacio; Filipiak, Krzysztof J; Flammer, Andreas; Fleck, Eckart; Gatzov, Plamen; Ginghina, Carmen; Goncalves, Lino; Haouala, Habib; Hassanein, Mahmoud; Heusch, Gerd; Huber, Kurt; Hulín, Ivan; Ivanusa, Mario; Krittayaphong, Rungroj; Lau, Chu-Pak; Marinskis, Germanas; Mach, François; Moreira, Luiz Felipe; Nieminen, Tuomo; Oukerraj, Latifa; Perings, Stefan; Pierard, Luc; Potpara, Tatjana; Reyes-Caorsi, Walter; Rim, Se-Joong; Rødevand, Olaf; Saade, Georges; Sander, Mikael; Shlyakhto, Evgeny; Timuralp, Bilgin; Tousoulis, Dimitris; Ural, Dilek; Piek, J J; Varga, Albert; Lüscher, Thomas F

    2017-05-01

    The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship - emphasizing the importance of responsibility and accountability-, have been proposed. Last year, a new editorial initiative to foster sharing of clinical trial data was launched. This review discusses this novel initiative with the aim of increasing awareness among readers, investigators, authors and editors belonging to the Editors´ Network of the European Society of Cardiology. Resumo O Comitê Internacional de Editores de Revistas Médicas (ICMJE) fornece recomendações para aprimorar o padrão editorial e a qualidade científica das revistas biomédicas. Tais recomendações variam desde requisitos técnicos de uniformização até assuntos editoriais mais complexos e elusivos, como os aspectos éticos do processo científico. Recentemente, foram propostos registro de ensaios clínicos, divulgação de conflitos de interesse e novos critérios de autoria, enfatizando a importância da responsabilidade e da responsabilização. No último ano, lançou-se uma nova iniciativa editorial para fomentar o compartilhamento dos dados de ensaios clínicos. Esta revisão discute essa nova iniciativa visando a aumentar a conscientização de leitores, investigadores, autores e editores filiados à Rede de Editores da Sociedade Europeia de Cardiologia.

  10. Herlyn-Werner-Wunderlich Syndrome with Unilateral Hemivaginal Obstruction, Ipsilateral Renal Agenesis, and Contralateral Renal Thin GBM Disease: A Case Report with Radiological Follow Up

    Energy Technology Data Exchange (ETDEWEB)

    Park, Noh Hyuck; Park, Hee Jin; Park, Chan Sup [Myongji Hospital, Kwandong University, Koyang (Korea, Republic of); Park, Sung Il [Bucheon Hospital, Soonchunhyang University, Bucheon (Korea, Republic of)

    2010-08-15

    Herlyn-Werner-Wunderlich syndrome is a rare Mullerian ductal anomaly that is characterized by the presence of a hemivaginal septum, a didelphic uterus and ipsilateral renal agenesis. It is generally difficult to diagnose the uterine malformation before menarche owing to its small size. Therefore, a follow-up study is very important for confirming the uterine malformation in girls with renal agenesis. We report a patient with renal agenesis and microscopic hematuria, who showed symptoms before menarche. A follow-up study eventually revealed uterine didelphys with a hemivaginal obstruction. A biopsy proved that the microscopic hematuria was caused by thin glomerular basement membrane disease of the contralateral kidney

  11. Werner Syndrome Combined with Meningeoma: Nursing on A Case%Werner综合征伴发脑膜瘤患者一例的护理

    Institute of Scientific and Technical Information of China (English)

    苏继敏; 张秀云; 高红伟; 段宇红; 宋晓东

    2010-01-01

    @@ Werner综合征(Werner syndrome,WS)又称成人早老综合征(adult progeria)、成人早衰老综合征(adult premature aging syndrome),是一种罕见的常染色体隐性遗传性疾病.WS多发于青春期,寿命常在40岁左右,而伴发脑膜瘤的WS病例更为罕见报道,在我国尚无报道.

  12. Herlyn-Werner-Wunderlich Syndrome: A Rare Cause of Pelvic Pain and High CA 19-9 Levels in an Adolescent Girl

    Science.gov (United States)

    Unal, Emel; Sonmezer, Murat; Erkol, Hatice Gul; Fitoz, Suat

    2016-01-01

    Herlyn-Werner-Wunderlich (HWW) syndrome is a rare developmental anomaly that includes uterus didelphys with obstructed hemivagina and ipsilateral renal agenesis. A 13-year-old girl presented with chronic abdominal pain. Magnetic resonance imaging revealed uterus didelphys, hematometrocolpos and renal agenesis on the right side with imperforate hymen. Subsequently the patient was found to have Mullerian duct anomalies. CA 19-9 level was high. At laparoscopy combined with vaginoscopy hematocolpos was drained following which she improved clinically and CA 19-9 level returned to normal. PMID:26816677

  13. O ANTI-REALISMO NA FILOSOFIA DA FÍSICA DE WERNER HEISENBERG: DA POTENTIA ARISTOTÉLICA AO FORMALISMO PURO

    Directory of Open Access Journals (Sweden)

    Vinicius Carvalho da Silva

    2011-06-01

    Full Text Available Qual a Filosofia da Natureza que podemos inferir da Física Contemporânea? Para Werner Karl Heisenberg, prêmio Nobel de Física de 1932, a ontologia da Ciência Moderna, estruturada no materialismo, no mecanicismo e no determinismo já não pode servir de fundamento para a nova Física. Esta requer uma nova base ontológica, onde o anti-realismo, seguido de um formalismo puro, aparece como o princípio basilar de uma nova Filosofia Natural.

  14. 一位世纪法学家的百年:维尔纳·弗卢梅%The 100 Years of a Centenarian Jurist, Werner Flume

    Institute of Scientific and Technical Information of China (English)

    托马斯·洛宾格; 颜晶晶

    2009-01-01

    @@ 每一位初涉法学的学生在大学的第一学期都会与他不期而遇.维尔纳·弗卢梅(Werner Flume):法律行为学说教科书[1]的作者--他在这一领域的造诣迄今为止尚无人能及--在2008年9月12日度过了他的百岁华诞.

  15. 德国Horauf决定在上海设厂——访Horauf公司总裁Werner U.Stahlecker先生

    Institute of Scientific and Technical Information of China (English)

    丁世华

    2008-01-01

    德国Horauf公司生产的装订设备在世界上闻名遐迩,在欧洲市场上占有率达到70%。得悉德国Horauf公司决定在青浦设厂,而该公司总裁Werner U.Stahlecker正在上海考察,本刊等3家媒体的记者对其进行了一次集体采访。

  16. The fourteen editors of the Journal of the South African Veterinary Association: 1927-2000 : information

    Directory of Open Access Journals (Sweden)

    R.D. Bigalke

    2000-07-01

    Full Text Available The initial motivation for having an article on the editors of the journal published in the year 2000 was to commemorate the 70 years of the existence of the Journal of the South African Veterinary Association. However, in conducting the research required to write the article it was established that the journal dates from 1927. Consequently the journal was about 73 rather than 70 years old at the end of 1999. During this period it has been faithfully served by 14 editors. This article contains a relatively brief description of the life histories, in relation to their terms of office as editors, of these editors, of whom 4 are still alive and actively pursuing their respective careers

  17. Mentoring for text editors: Fit for purpose in the era of freelancing ...

    African Journals Online (AJOL)

    Kate H

    It shows that mentoring is fundamentally different from these strategies according ... associations of text editors, this article describes the adult learning theories of ... distinguishing between mentoring, coaching, counselling, teaching and ...... focuses on specific psychological help, personal growth and career guidance.

  18. Concomitant leg injuries in raptors with wing damage : to the editor

    National Research Council Canada - National Science Library

    Buttle, E. Pohlandt

    2004-01-01

    Extracted from text ... To the editor - Aan die redakteur Concomitant leg injuries in raptors with wing damage Juvenile raptors, in their first year, often experience trauma to the wings as they miss their prey or misjudge...

  19. Personalized Medicine Across Disciplines and without Borders. Vural Özdemir speaks to Hannah Wilson, Commissioning Editor

    Science.gov (United States)

    Özdemir, Vural

    2015-01-01

    Vural Özdemir began his career as a medical doctor in Turkey in 1990, as a scientist at the Faculty of Medicine, University of Toronto (ON, Canada), where he obtained his MSc and PhD in clinical pharmacology (1998), and subsequently completed a 4-year postdoctoral fellowship in personalized medicine with the late Werner Kalow, a founding pioneer in the field of pharmacogenetics. Özdemir contributed to the conception and development of the repeated drug administration (RDA) method as a novel way of measuring pharmacological heritability, pharmacogenetics of psychiatric drugs and studying the clinical role of CYP2D6 genetic variations for endogenous neurotransmitter metabolism in the human brain. Recognizing that scientific knowledge is a product of both technology and social systems that often remain unaccounted for (e.g., human values, distribution of power and human agency, immigration, racial disparities, socioeconomic class and equity), Özdemir discovered the literature in the field of science and technology studies, a rich scholarly enquiry that asks fundamental questions and challenges assumptions regarding the backstage of technoscience, situates technology within its political context and makes hitherto unseen connections that frame science in ways that enable robust, responsible and sustainable innovation. From 2008 to 2012, Özdemir was awarded a mid-career “science and society” fellowship in order to retool as independent faculty and senior scientist in science and technology studies (STS), conducting research on research and examining his own trade – pharmacogenetics science – as an insider on the outside. Recently, Özdemir was awarded senior career support from the Scientific and Tehnological Research Council of Turkey, is an Associate Professor of both Communications and Human Genetics at the Faculty of Communications and serves as an advisor to the Rector for International Technology and Innovation Policy, Gaziantep University in Turkey

  20. Editor's welcome, PORTAL, Vol. 6, No. 1, January 2009

    Directory of Open Access Journals (Sweden)

    Paul Allatson

    2009-08-01

    Full Text Available ‘The Space Between: Languages, Translations and Cultures’ is a special issue of PORTAL Journal of Multidisciplinary International Studies guest-edited by Vera Mackie (University of Melbourne, Ikuko Nakane (University of Melbourne, and Emi Otsuji (University of Technology, Sydney. As Vera Mackie and Stephanie Hemelryk Donald (University of Sydney say in the introduction to the special issue: All of the contributors to this special issue have reflected on the stakes involved in negotiating differences in language and culture. In their research and professional practice they inhabit the ‘space between’: the space between languages, the space between cultures, and the space between academic disciplines. While many of our contributors are located in the Australian university system, we also have contributors from outside that system, as well as contributors who are theorising disparate sites for the negotiation of difference. The most exciting aspect of the papers presented here is the ability to move between the spheres of cultural theory and the everyday. Analytical techniques originally developed for literary and cultural analysis are brought to bear on the texts and practices of everyday life. In addition to the critical essays, three cultural works also intervene in the discussion over what it means to inhabit the ‘space between’ languages, cultures and countries. The guest editors and the PORTAL editorial committee would like to acknowledge and thank the following institutions and individual for the support that made this special issue possible: the Australian Research Council’s Cultural Research Network; the former Institute for International Studies at the University of Technology, Sydney; the School of Historical Studies at the University of Melbourne; and the ARC Cultural Literacies Node Convener, Mark Gibson.