WorldWideScience

Sample records for volume change exponentially

  1. Exponential reduction of finite volume effects with twisted boundary conditions

    CERN Document Server

    Cherman, Aleksey; Wagman, Michael L; Yaffe, Laurence G

    2016-01-01

    Flavor-twisted boundary conditions can be used for exponential reduction of finite volume artifacts in flavor-averaged observables in lattice QCD calculations with $SU(N_f)$ light quark flavor symmetry. Finite volume artifact reduction arises from destructive interference effects in a manner closely related to the phase averaging which leads to large $N_c$ volume independence. With a particular choice of flavor-twisted boundary conditions, finite volume artifacts for flavor-singlet observables in a hypercubic spacetime volume are reduced to the size of finite volume artifacts in a spacetime volume with periodic boundary conditions that is four times larger.

  2. Biochemical kinetics in changing volumes.

    Science.gov (United States)

    Pawłowski, Piotr H; Zielenkiewicz, Piotr

    2004-01-01

    The need of taking into account the change of compartment volume when developing chemical kinetics analysis inside the living cell is discussed. Literature models of a single enzymatic Michaelis-Menten process, glycolytic oscillations, and mitotic cyclin oscillations were tested with appropriate theoretical extension in the direction of volume modification allowance. Linear and exponential type of volume increase regimes were compared. Due to the above, in a growing cell damping of the amplitude, phase shift, and time pattern deformation of the metabolic rhythms considered were detected, depending on the volume change character. The performed computer simulations allow us to conclude that evolution of the cell volume can be an essential factor of the chemical kinetics in a growing cell. The phenomenon of additional metabolite oscillations caused by the periodic cell growth and division was theoretically predicted and mathematically described. Also, the hypothesis of the periodized state in the growing cell as the generalization of the steady-state was formulated.

  3. Vibrations of FGM thin cylindrical shells with exponential volume fraction law

    Institute of Scientific and Technical Information of China (English)

    Abdul Ghafar Shah; Tahir Mahmood; Muhammad Nawaz Naeem

    2009-01-01

    In this paper,the influence of an exponential volume fraction law on the vibration frequencies of thin functionally graded cylindrical shells is studied. Material properties in the shell thickness direction are graded in accordance with the exponential law. Expressions for the strain-displacement and curvature-displacement relationships are taken from Love's thin shell theory. The Rayleigh-Ritz approach is used to derive the shell eigenfrequency equation. Axial modal dependence is assumed in the characteristic beam functions. Natural frequencies of the shells are observed to be dependent on the constituent volume fractions. The results are compared with those available in the literature for the validity of the present methodology.

  4. PRESSURE-VOLUME ANALYSIS OF THE LUNG WITH AN EXPONENTIAL AND LINEAR-EXPONENTIAL MODEL IN ASTHMA AND COPD

    NARCIS (Netherlands)

    BOGAARD, JM; OVERBEEK, SE; VERBRAAK, AFM; VONS, C; FOLGERING, HTM; VANDERMARK, TW; ROOS, CM; STERK, PJ

    1995-01-01

    The prevalence of abnormalities in lung elasticity in patients with asthma or chronic obstructive pulmonary disease (COPD) is still unclear, This might be due to uncertainties concerning the method of analysis of quasistatic deflation long pressure-volume curves. Pressure-volume curves were obtained

  5. Exponential Martingales and Changes of Measure for Counting Processes

    DEFF Research Database (Denmark)

    Sokol, Alexander; Hansen, Niels Richard

    2015-01-01

    We give sufficient criteria for the Doléans-Dade exponential of a stochastic integral with respect to a counting process local martingale to be a true martingale. The criteria are adapted particularly to the case of counting processes and are sufficiently weak to be useful and verifiable, as we i...... illustrate by several examples. In particular, the criteria allow for the construction of for example nonexplosive Hawkes processes, counting processes with stochastic intensities depending on diffusion processes as well as inhomogeneous finite-state Markov processes....

  6. Non-constant volume exponential solutions in higher-dimensional Lovelock cosmologies

    CERN Document Server

    Chirkov, Dmitry; Toporensky, Alexey

    2015-01-01

    In this paper we propose a scheme which allows one to find all possible exponential solutions of special class -- non-constant volume solutions -- in Lovelock gravity in arbitrary number of dimensions and with arbitrate combinations of Lovelock terms. We apply this scheme to (6+1)- and (7+1)-dimensional flat anisotropic cosmologies in Einstein-Gauss-Bonnet and third-order Lovelock gravity to demonstrate how our scheme does work. In course of this demonstration we derive all possible solutions in (6+1) and (7+1) dimensions and compare solutions and their abundance between cases with different Lovelock terms present. As a special but more "physical" case we consider spaces which allow three-dimensional isotropic subspace for they could be viewed as examples of compactification schemes. Our results suggest that the same solution with three-dimensional isotropic subspace is more "probable" to occur in the model with most possible Lovelock terms taken into account, which could be used as kind of anthropic argument...

  7. On stable exponential cosmological solutions with non-static volume factor in the Einstein-Gauss-Bonnet model

    Science.gov (United States)

    Ivashchuk, V. D.; Ernazarov, K. K.

    2017-01-01

    A (n + 1)-dimensional gravitational model with cosmological constant and Gauss-Bonnet term is studied. The ansatz with diagonal cosmological metrics is adopted and solutions with exponential dependence of scale factors: ai ∼ exp (vit), i = 1, …, n, are considered. The stability analysis of the solutions with non-static volume factor is presented. We show that the solutions with v 1 = v 2 = v 3 = H > 0 and small enough variation of the effective gravitational constant G are stable if certain restriction on (vi ) is obeyed. New examples of stable exponential solutions with zero variation of G in dimensions D = 1 + m + 2 with m > 2 are presented.

  8. On stability of exponential cosmological solutions with non-static volume factor in the Einstein-Gauss-Bonnet model

    CERN Document Server

    Ivashchuk, V D

    2016-01-01

    A (n+1)-dimensional gravitational model with Gauss-Bonnet term and cosmological constant term is considered. When ansatz with diagonal cosmological metrics is adopted, the solutions with exponential dependence of scale factors: a_i \\sim \\exp{ ( v^i t) }, i =1, ..., n, are analysed for n > 3. We study the stability of the solutions with non-static volume factor, i.e. if K(v) = \\sum_{k = 1}^{n} v^k \

  9. Transition from exponential to linear photoautotrophic growth changes the physiology of Synechocystis sp. PCC 6803.

    Science.gov (United States)

    Schuurmans, R M; Matthijs, J C P; Hellingwerf, K J

    2017-04-01

    Phototrophic microorganisms like cyanobacteria show growth curves in batch culture that differ from the corresponding growth curves of chemotrophic bacteria. Instead of the usual three phases, i.e., lag-, log-, and stationary phase, phototrophs display four distinct phases. The extra growth phase is a phase of linear, light-limited growth that follows the exponential phase and is often ignored as being different. Results of this study demonstrate marked growth phase-dependent alterations in the photophysiology of the cyanobacterium Synechocystis sp. PCC 6803 between cells harvested from the exponential and the linear growth phase. Notable differences are a gradual shift in the energy transfer of the light-harvesting phycobilisomes to the photosystems and a distinct change in the redox state of the plastoquinone pool. These differences will likely affect the result of physiological studies and the efficiency of product formation of Synechocystis in biotechnological applications. Our study also demonstrates that the length of the period of exponential growth can be extended by a gradually stronger incident light intensity that matches the increase of the cell density of the culture.

  10. Plasma volume changes during hypoglycaemia

    DEFF Research Database (Denmark)

    Hilsted, J; Frandsen, Henrik Lund; Christensen, N J

    1991-01-01

    -induced hypoglycaemia with total autonomic blockade (alpha-adrenoceptor blockade combined with beta-adrenoceptor blockade and atropine); and insulin-induced hypoglycaemia without any autonomic blockade. In the experiments without autonomic blockade the peripheral venous hematocrit increased, plasma volume decreased......, intravascular albumin content decreased and the transcapillary escape rate of albumin increased. In both experiments with autonomic blockade the increase in venous haematocrit was abolished, yet plasma volume decreased, intravascular albumin content decreased and the transcapillary escape rate of albumin...... increased in these experiments. Thus, the changes in plasma volume and composition in response to hypoglycaemia are due to the combined actions of adrenaline and of insulin....

  11. Plasma volume changes during hypoglycaemia

    DEFF Research Database (Denmark)

    Hilsted, J; Bendtsen, F; Christensen, N J

    1990-01-01

    To investigate whether previously reported changes in venous blood volume and composition induced by acute hypoglycaemia in humans are representative for the entire body we measured erythrocyte 51Cr content, haematocrit, plasma volume, intravascular albumin content and transcapillary escape rate...... of albumin in arterial and venous blood in seven healthy subjects before and during insulin-induced hypoglycaemia. In both vascular sites blood 51Cr content and the haematocrit increased, plasma volume and intravascular albumin content decreased and the transcapillary escape rate of albumin increased during...

  12. On stability of exponential cosmological solutions with non-static volume factor in the Einstein-Gauss-Bonnet model

    Energy Technology Data Exchange (ETDEWEB)

    Ivashchuk, V.D. [VNIIMS, Center for Gravitation and Fundamental Metrology, Moscow (Russian Federation); Peoples' Friendship University of Russia (RUDN University), Institute of Gravitation and Cosmology, Moscow (Russian Federation)

    2016-08-15

    A (n + 1)-dimensional gravitational model with Gauss-Bonnet term and a cosmological constant term is considered. When ansatz with diagonal cosmological metrics is adopted, the solutions with an exponential dependence of the scale factors, a{sub i} ∝ exp(v{sup i}t), i = 1,.., n, are analyzed for n > 3. We study the stability of the solutions with non-static volume factor, i.e. K(v) = sum {sub k=1}{sup n} v{sup k} ≠ 0. We prove that under a certain restriction R imposed solutions with K(v) > 0 are stable, while solutions with K(v) < 0 are unstable. Certain examples of stable solutions are presented. We show that the solutions with v{sup 1} = v{sup 2} = v{sup 3} = H > 0 and zero variation of the effective gravitational constant are stable if the restriction R is obeyed. (orig.)

  13. Exponential triples

    CERN Document Server

    Sisto, Alessandro

    2011-01-01

    Using ultrafilter techniques we show that in any partition of $\\mathbb{N}$ into 2 cells there is one cell containing infinitely many exponential triples, i.e. triples of the kind $a,b,a^b$ (with $a,b>1$). Also, we will show that any multiplicative $IP^*$ set is an "exponential $IP$ set", the analogue of an $IP$ set with respect to exponentiation.

  14. On the phi-divergence test statistics for the change point problem in a sequence of exponentially distributed random variables

    CERN Document Server

    Apostolos, Batsidis; Leandro, Pardo; Konstantinos, Zografos

    2011-01-01

    Recently Batsidis et al. (2011) have presented a new procedure based on divergence measures for testing the hypothesis of the existence of a change point in exponential populations. A simulation study was carried out using the asymptotic critical points obtained from the asymptotic distribution of the new test statistics introduced. The main purpose of this paper is to use the behavior of the test statistics introduced in the cited paper of Batsidis et al. (2011) using simulated critical points.

  15. Approximate models for the study of exponential changed quantities: Application on the plasma waves growth rate or damping

    Energy Technology Data Exchange (ETDEWEB)

    Xaplanteris, C. L., E-mail: cxaplanteris@yahoo.com [Plasma Physics Laboratory, IMS, NCSR “Demokritos”, Athens, Greece and Hellenic Army Academy, Vari Attica (Greece); Xaplanteris, L. C. [School of Physics, National and Kapodistrian University of Athens, Athens (Greece); Leousis, D. P. [Technical High School of Athens, Athens (Greece)

    2014-03-15

    Many physical phenomena that concern the research these days are basically complicated because of being multi-parametric. Thus, their study and understanding meets with big if not unsolved obstacles. Such complicated and multi-parametric is the plasmatic state as well, where the plasma and the physical quantities that appear along with it have chaotic behavior. Many of those physical quantities change exponentially and at most times they are stabilized by presenting wavy behavior. Mostly in the transitive state rather than the steady state, the exponentially changing quantities (Growth, Damping etc) depend on each other in most cases. Thus, it is difficult to distinguish the cause from the result. The present paper attempts to help this difficult study and understanding by proposing mathematical exponential models that could relate with the study and understanding of the plasmatic wavy instability behavior. Such instabilities are already detected, understood and presented in previous publications of our laboratory. In other words, our new contribution is the study of the already known plasmatic quantities by using mathematical models (modeling and simulation). These methods are both useful and applicable in the chaotic theory. In addition, our ambition is to also conduct a list of models useful for the study of chaotic problems, such as those that appear into the plasma, starting with this paper's examples.

  16. Cyanide-insensitive respiration in Acanthamoeba castellanii. Changes in sensitivity of whole cell respiration during exponential growth

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, S.W.; Lloyd, D.

    1977-01-01

    Respiration of Acanthamoeba castellanii shows varying sensitivity to cyanide during exponential growth in a medium containing proteose peptone, glucose and yeast extract. After 20 h growth, respiration was stimulated up to 40% by I mM-cyanide; sensitivity to cyanide then gradually increased until 90% inhibition of respiration was attained in late exponential phase cultures. Salicyl hydroxamic acid alone never stimulated or inhibited respiration by more than 20% but, when added together with cyanide, inhibition was always 70 to 100% from 3 h onward. Sensitivity to antimycin A was similar, but not identical to that shown to cyanide; when antimycin A was added together with salicyl hydroxamic acid, the inhibition was greater. Increased sensitivities to arsenite and malonate were also observed in late-exponential phase cultures. These changes in sensitivities were not associated with alterations in the growth medium since similar changes in sensitivity to inhibitors were observed during growth in conditioned medium. A rotenone-sensitive site is associated with cyanide-stimulated respiration and the results suggest that A. castellanii possesses a branched electron transport system.

  17. Dynamic proteome changes of Shigella flexneri 2a during transition from exponential growth to stationary phase.

    Science.gov (United States)

    Zhu, Li; Liu, Xian-Kai; Zhao, Ge; Zhi, Yi-Dan; Bu, Xin; Ying, Tian-Yi; Feng, Er-Ling; Wang, Jie; Zhang, Xue-Min; Huang, Pei-Tang; Wang, Heng-Liang

    2007-05-01

    Shigella flexneri is an infectious pathogen that causes dysentery to human, which remains a serious threat to public health, particularly in developing countries. In this study, the global protein expression patterns of S. flexneri during transition from exponential growth to stationary phase in vitro were analyzed by using 2-D PAGE combined with MALDI-TOF MS. In a time-course experiment with five time points, the relative abundance of 49 protein spots varied significantly. Interestingly, a putative outer membrane protein YciD (OmpW) was almost not detected in the exponential growth phase but became one of the most abundant proteins in the whole stationary-phase proteome. Some proteins regulated by the global regulator FNR were also significantly induced (such as AnsB, AspA, FrdAB, and KatG) or repressed (such as AceEF, OmpX, SodA, and SucAB) during the growth phase transition. These proteins may be the key effectors of the bacterial cell cycle or play important roles in the cellular maintenance and stress responses. Our expression profile data provide valuable information for the study of bacterial physiology and form the basis for future proteomic analyses of this pathogen.

  18. Dynamic Proteome Changes of Shigella flexneri 2a During Transition from Exponential Growth to Stationary Phase

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Shigella flexneri is an infectious pathogen that causes dysentery to human, which remains a serious threat to public health, particularly in developing countries. In this study, the global protein expression patterns of S. flexneri during transition from exponential growth to stationary phase in vitro were analyzed by using 2-D PAGE combined with MALDI-TOF MS. In a time-course experiment with five time points, the relative abundance of 49 protein spots varied significantly. In terestingly, a putative outer membrane protein YciD (OmpW) was almost not detected in the exponential growth phase but became one of the most abundant proteins in the whole stationary-phase proteome. Some proteins regulated by the global regulator FNR were also significantly induced (such as AnsB, AspA, FrdAB,and KatG) or repressed (such as AceEF, OmpX, SodA, and SucAB) during the growth phase transition. These proteins may be the key effectors of the bacterial cell cycle or play important roles in the cellular maintenance and stress responses.Our expression profile data provide valuable information for the study of bacterial physiology and form the basis for future proteomic analyses of this pathogen.

  19. Option Pricing for Time-Change Exponential Levy Model Under Memm

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The purpose of this article is to study the rational evaluation of European options price when the underlying price process is described by a time-change Levy process. European option pricing formula is obtained under the minimal entropy martingale measure (MEMM) and applied to several examples of particular time-change Levy processes. It can be seen that the framework in this paper encompasses the Black-Scholes model and almost all of the models proposed in the subordinated market.

  20. On the gap between an empirical distribution and an exponential distribution of waiting times for price changes in a financial market

    CERN Document Server

    Sazuka, N

    2006-01-01

    We analyze waiting times for price changes in a foreign currency exchange rate. Recent empirical studies of high frequency financial data support that trades in financial markets do not follow a Poisson process and the waiting times between trades are not exponentially distributed. Here we show that our data is well approximated by a Weibull distribution rather than an exponential distribution in a non-asymptotic regime. Moreover, we quantitatively evaluate how much an empirical data is far from an exponential distribution using a Weibull fit. Finally, we discuss a phase transition between a Weibull-law and a power-law in the asymptotic long waiting time regime.

  1. The exponential rank of nonarchimedean exponential fields

    OpenAIRE

    Kuhlmann, Franz-Viktor; Kuhlmann, Salma

    2000-01-01

    For an exponential on a nonarchimedean ordered field, we introduce the notion of the exponential rank, in analogy to the rank of the field. This gives information about the growth rate of the exponential, and about the convex valuations on the field which are compatible with the exponential. We give several characterizations of these valuations, using maps induced by the exponential on the value group of the natural valuation and on the rank of the field. Finally, we construct exponential fie...

  2. Apparatus for determining changes in limb volume

    Science.gov (United States)

    Bhagat, P. K.; Wu, V. C. (Inventor)

    1981-01-01

    Measuring apparatus for determining changes in the volume of limbs or other boty extremities by determining the cross-sectional area of such limbs many comprise a transmitter including first and second transducers for positioning on the surface of the limb at a predetermined distance there between, and a receiver including a receiver crystal for positioning on the surface of the limb. The distance between the receiver crystal and the first and second transducers are represented by respective first and second chords of the cross-section of the limb and the predetermined distance between the first and second transducers is represented by a third chord of the limb cross section.

  3. Correlation between the change in the kinetics of the ribosomal RNA rrnB P2 promoter and the transition from lag to exponential phase with Pseudomonas fluorescens.

    Science.gov (United States)

    McKellar, Robin C

    2008-01-15

    Developing accurate mathematical models to describe the pre-exponential lag phase in food-borne pathogens presents a considerable challenge to food microbiologists. While the growth rate is influenced by current environmental conditions, the lag phase is affected in addition by the history of the inoculum. A deeper understanding of physiological changes taking place during the lag phase would improve accuracy of models, and in earlier studies a strain of Pseudomonas fluorescens containing the Tn7-luxCDABE gene cassette regulated by the rRNA promoter rrnB P2 was used to measure the influence of starvation, growth temperature and sub-lethal heating on promoter expression and subsequent growth. The present study expands the models developed earlier to include a model which describes the change from exponential to linear increase in promoter expression with time when the exponential phase of growth commences. A two-phase linear model with Poisson weighting was used to estimate the lag (LPDLin) and the rate (RLin) for this linear increase in bioluminescence. The Spearman rank correlation coefficient (r=0.830) between the LPDLin and the growth lag phase (LPDOD) was extremely significant (Pexponential growth. These results suggest that models based on measurable physiological changes in the cells can be useful in predicting the behaviour of food-borne pathogens.

  4. Estimating the rates of mass change, ice volume change and snow volume change in Greenland from ICESat and GRACE data

    NARCIS (Netherlands)

    Slobbe, D.C.; Ditmar, P.G.; Lindenbergh, R.C.

    2008-01-01

    The focus of this paper is on the quantification of ongoing mass and volume changes over the Greenland ice sheet. For that purpose, we used elevation changes derived from the Ice, Cloud, and land Elevation Satellite (ICESat) laser altimetry mission and monthly variations of the Earth’s gravity field

  5. Human choice and climate change. Volume 2: Resources and technology

    Energy Technology Data Exchange (ETDEWEB)

    Raynor, S.; Malone, E. [eds.] [Pacific Northwest National Lab., Richland, WA (United States)

    1998-12-31

    This book is Volume 2 of a four-volume set which assesses social science research that is relevant to global climate change from a wide-ranging interdisciplinary perspective. Attention is focused on resources and technology as they relate to climate change. This series is indispensable reading for scientists and engineers wishing to make an effective contribution to the climate change policy debate.

  6. Power law cross-correlations between price change and volume change of Indian stocks

    Science.gov (United States)

    Hasan, Rashid; Mohammed Salim, M.

    2017-05-01

    We study multifractal long-range correlations and cross-correlations of daily price change and volume change of 50 stocks that comprise Nifty index of National Stock Exchange, Mumbai, using MF-DFA and MF-DCCA methods. We find that the time series of price change are uncorrelated, whereas anti-persistent long-range multifractal correlations are found in volume change series. We also find antipersistent long-range multifractal cross-correlations between the time series of price change and volume change. As multifractality is a signature of complexity, we estimate complexity parameters of the time series of price change, volume change, and cross-correlated price-volume change by fitting the fourth-degree polynomials to their multifractal spectra. Our results indicate that the time series of price change display high complexity, whereas the time series of volume change and cross-correlated price-volume change display low complexity.

  7. Residual limb volume change: Systematic review of measurement and management

    Directory of Open Access Journals (Sweden)

    Joan E. Sanders, PhD

    2011-10-01

    Full Text Available Management of residual limb volume affects decisions regarding timing of fit of the first prosthesis, when a new prosthetic socket is needed, design of a prosthetic socket, and prescription of accommodation strategies for daily volume fluctuations. This systematic review assesses what is known about measurement and management of residual limb volume change in persons with lower-limb amputation. Publications that met inclusion criteria were grouped into three categories: group I: descriptions of residual limb volume measurement techniques; group II: studies investigating the effect of residual limb volume change on clinical care in people with lower-limb amputation; and group III: studies of residual limb volume management techniques or descriptions of techniques for accommodating or controlling residual limb volume. We found that many techniques for the measurement of residual limb volume have been described but clinical use is limited largely because current techniques lack adequate resolution and in-socket measurement capability. Overall, limited evidence exists regarding the management of residual limb volume, and the evidence available focuses primarily on adults with transtibial amputation in the early postoperative phase. While we can draw some insights from the available research about residual limb volume measurement and management, further research is required.

  8. A volume change index for forest growth and sustainability

    Science.gov (United States)

    Paul Van Deusen; Francis Roesch

    2009-01-01

    A volume change index is suggested that is derived from growth components that can be estimated from remeasured plots. The new index incorporates more information than the traditional growth over removals, ratio. The new index directly indicates whether the standing volume will be increasing or decreasing if current conditions persist, whereas the ratio of...

  9. Test Exponential Pile

    Science.gov (United States)

    Fermi, Enrico

    The Patent contains an extremely detailed description of an atomic pile employing natural uranium as fissile material and graphite as moderator. It starts with the discussion of the theory of the intervening phenomena, in particular the evaluation of the reproduction or multiplication factor, K, that is the ratio of the number of fast neutrons produced in one generation by the fissions to the original number of fast neutrons, in a system of infinite size. The possibility of having a self-maintaining chain reaction in a system of finite size depends both on the facts that K is greater than unity and the overall size of the system is sufficiently large to minimize the percentage of neutrons escaping from the system. After the description of a possible realization of such a pile (with many detailed drawings), the various kinds of neutron losses in a pile are depicted. Particularly relevant is the reported "invention" of the exponential experiment: since theoretical calculations can determine whether or not a chain reaction will occur in a give system, but can be invalidated by uncertainties in the parameters of the problem, an experimental test of the pile is proposed, aimed at ascertaining if the pile under construction would be divergent (i.e. with a neutron multiplication factor K greater than 1) by making measurements on a smaller pile. The idea is to measure, by a detector containing an indium foil, the exponential decrease of the neutron density along the length of a column of uranium-graphite lattice, where a neutron source is placed near its base. Such an exponential decrease is greater or less than that expected due to leakage, according to whether the K factor is less or greater than 1, so that this experiment is able to test the criticality of the pile, its accuracy increasing with the size of the column. In order to perform this measure a mathematical description of the effect of neutron production, diffusion, and absorption on the neutron density in the

  10. Extended Poisson Exponential Distribution

    Directory of Open Access Journals (Sweden)

    Anum Fatima

    2015-09-01

    Full Text Available A new mixture of Modified Exponential (ME and Poisson distribution has been introduced in this paper. Taking the Maximum of Modified Exponential random variable when the sample size follows a zero truncated Poisson distribution we have derived the new distribution, named as Extended Poisson Exponential distribution. This distribution possesses increasing and decreasing failure rates. The Poisson-Exponential, Modified Exponential and Exponential distributions are special cases of this distribution. We have also investigated some mathematical properties of the distribution along with Information entropies and Order statistics of the distribution. The estimation of parameters has been obtained using the Maximum Likelihood Estimation procedure. Finally we have illustrated a real data application of our distribution.

  11. Volume change theory for syringomyelia: A new perspective.

    Science.gov (United States)

    Rai, Survendra Kumar Rajdeo; Rai, Pooja Survendra Kumar

    2015-01-01

    The etiopathogenesis of syringomyelia is still an enigma. The authors present a novel theory based on fluid dynamics at the craniovertebral (CV) junction to explain the genesis of syringomyelia (SM). The changes in volume of spinal canal, spinal cord, central canal and spinal subarachnoid space (SSS) in relation to the posterior fossa have been analysed, specifically during postural movements of flexion and extension. The effect of fluctuations in volume of spinal canal and its contents associated with cerebrospinal fluid (CSF) flow dynamics at the CV junction have been postulated to cause the origin and propagation of the syringomyelia. The relevant literature on the subject has been reviewed and the author's theory has been discussed. Volume of spinal canal in flexion is always greater than that in extension. Flexion of spine causes narrowing of the ventral subarachnoid space (SAS) and widening of dorsal SAS while extension causes reverse changes leading to fluid movement in dorsal spinal SAS in flexion and ventral spinal SAS in extension. Cervical and lumbar spinal region with maximum bulk hence maximum area and volume undergo maximum deformation during postural changes. SSS CSF is the difference between the volume of spinal canal and spinal cord, varies in flexion and extension which is compensated by changes in posterior fossa (CSF) volume in normal circumstances. Blocked SAS at foramen magnum donot permit spinal SAS CSF exchange which during postural changes is compensated by cavitatory/cystic (syrinx) change at locations in cervical and lumbar spine with propensity for maximum deformation. Augmentation of posterior fossa volume by decompression helps by normalization of this CSF exchange dynamics but immobilizing the spinal movement theoretically will cease any dynamic volume changes thereby minimizing the destructive influence of the fluid exchange on the cord. Thus, this theory strengthens the rational of treating patients by either methodology.

  12. Weighted exponential polynomial approximation

    Institute of Scientific and Technical Information of China (English)

    邓冠铁

    2003-01-01

    A necessary and sufficient condition for completeness of systems of exponentials with a weightin Lp is established and a quantitative relation between the weight and the system of exponential in Lp isobtained by using a generalization of Malliavin's uniqueness theorem about Watson's problem.

  13. Exponential Dowling structures

    CERN Document Server

    Ehrenborg, Richard

    2010-01-01

    The notion of exponential Dowling structures is introduced, generalizing Stanley's original theory of exponential structures. Enumerative theory is developed to determine the M\\"obius function of exponential Dowling structures, including a restriction of these structures to elements whose types satisfy a semigroup condition. Stanley's study of permutations associated with exponential structures leads to a similar vein of study for exponential Dowling structures. In particular, for the extended r-divisible partition lattice we show the M\\"obius function is, up to a sign, the number of permutations in the symmetric group on rn+k elements having descent set {r, 2r, ..., nr}. Using Wachs' original EL-labeling of the r-divisible partition lattice, the extended r-divisible partition lattice is shown to be EL-shellable.

  14. Quantifying Volume Changing Perturbations in a Wave Chaotic System

    CERN Document Server

    Taddese, Biniyam Tesfaye; Moglie, Franco; Antonsen, Thomas M; Ott, Edward; Anlage, Steven M

    2012-01-01

    A sensor was developed to quantitatively measure perturbations which change the volume of a wave chaotic cavity while leaving its shape intact. The sensors work in the time domain by using either scattering fidelity of the transmitted signals or the classical analog of the Loschmidt echo. The sensors were tested experimentally by inducing volume changing perturbations to a one cubic meter pseudo-integrable, real-world cavity. Perturbations which caused a volume change that is as small as 54 parts in a million were quantitatively measured. These results were obtained by using electromagnetic waves with a wavelength of about $5cm$, therefore, the sensor is sensitive to extreme sub-wavelength changes of the boundaries of a cavity. The experimental results were compared with Finite Difference Time Domain (FDTD) simulation results, and good agreement was found. Furthermore, the sensor was tested using a frequency domain approach on a numerical model of the star graph, which is a representative wave chaotic system....

  15. Changes of pituitary gland volume in Kennedy disease.

    Science.gov (United States)

    Pieper, C C; Teismann, I K; Konrad, C; Heindel, W L; Schiffbauer, H

    2013-12-01

    Kennedy disease is a rare X-linked neurodegenerative disorder caused by a CAG repeat expansion in the first exon of the androgen-receptor gene. Apart from neurologic signs, this mutation can cause a partial androgen insensitivity syndrome with typical alterations of gonadotropic hormones produced by the pituitary gland. The aim of the present study was therefore to evaluate the impact of Kennedy disease on pituitary gland volume under the hypothesis that endocrinologic changes caused by partial androgen insensitivity may lead to morphologic changes (ie, hypertrophy) of the pituitary gland. Pituitary gland volume was measured in sagittal sections of 3D T1-weighted 3T-MR imaging data of 8 patients with genetically proven Kennedy disease and compared with 16 healthy age-matched control subjects by use of Multitracer by a blinded, experienced radiologist. The results were analyzed by a univariant ANOVA with total brain volume as a covariant. Furthermore, correlation and linear regression analyses were performed for pituitary volume, patient age, disease duration, and CAG repeat expansion length. Intraobserver reliability was evaluated by means of the Pearson correlation coefficient. Pituitary volume was significantly larger in patients with Kennedy disease (636 [±90] mm(3)) than in healthy control subjects (534 [±91] mm(3)) (P = .041). There was no significant difference in total brain volume (P = .379). Control subjects showed a significant decrease in volume with age (r = -0.712, P = .002), whereas there was a trend to increasing gland volume in patients with Kennedy disease (r = 0.443, P = .272). Gland volume correlated with CAG repeat expansion length in patients (r = 0.630, P = .047). The correlation coefficient for intraobserver reliability was 0.94 (P pituitary volume that correlated with the CAG repeat expansion length. This could reflect hypertrophy as the result of elevated gonadotropic hormone secretion caused by the androgen receptor mutation with partial

  16. Environmental law and climate change : Volumes I & II

    NARCIS (Netherlands)

    Verschuuren, Jonathan

    2015-01-01

    Two volume set that brings together 54 of the most influential and important scientific journal articles in the field of climate law, thematically grouped together as follows: introducing climate law, theories and approaches, climate change mitigation, climate change adaptation, climate justice, lia

  17. Pituitary volumes are changed in patients with conversion disorder.

    Science.gov (United States)

    Atmaca, Murad; Baykara, Sema; Mermi, Osman; Yildirim, Hanefi; Akaslan, Unsal

    2016-03-01

    Our study group previously measured pituitary volumes and found a relationship between somatoform disoders and pituitary volumes. Therefore, in conversion disorder, another somatoform disorder, we hypothesized that pituitary gland volumes would be reduced. Twenty female patients and healthy controls were recruited to the present investigation. The volumes of the pituitary gland were determined by using a 1.5 Tesla magnetic resonance scanner. We found that the pituitary gland volumes of the patients with conversion disorder were significantly smaller than those of healthy control subjects. In the patients with conversion disorder but not in the healthy control group, a significant negative correlation between the duration of illness and pituitary gland volume was determined. In summary, in the present study, we suggest that the patients with conversion disorder have smaller pituitary volumes compared to those of healthy control subjects. Further studies should confirm our data and ascertain whether volumetric alterations determined in the patients with conversion disorder can be changed with treatment or if they change over time.

  18. Experimental Study on Volume Change Indices of Bentonite Soils

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    This paper reports experimental results regarding statically compacted clay specimens to study the volume change behavior of bentonites. The volume change indices such as the coefficients of compressibility, volume compressibility, and consolidation ( i. e.av , mv and cv respectively) and the saturated coefficient of permeability k at different surcharge pressures were determined with the commonly adopted procedures. The swell potentials, swelling pressures, different phases of the swollen specimens were analyzed for the volume change behavior during compression. Experimental results revealed that the swell potential is dependent on the initial dry density, the initial water content and the vertical pressure at which the clay specimens were allowed to swell. The swelling pressure was found to be similar for the specimens with varying water content, showing strong dependency on the initial void ratio. The compression indices ( viz. mv and av) of saturated specimens decreased with an increase in the vertical pressure. About 80% to 90% of the volume change occurred in the primary compression phase under any given vertical pressure. The coefficient of consolidation cv and the saturated coefficient of permeability k decreased with an increase in the vertical pressure.

  19. An Unusual Exponential Graph

    Science.gov (United States)

    Syed, M. Qasim; Lovatt, Ian

    2014-01-01

    This paper is an addition to the series of papers on the exponential function begun by Albert Bartlett. In particular, we ask how the graph of the exponential function y = e[superscript -t/t] would appear if y were plotted versus ln t rather than the normal practice of plotting ln y versus t. In answering this question, we find a new way to…

  20. Epidural anesthesia, hypotension, and changes in intravascular volume

    DEFF Research Database (Denmark)

    Holte, Kathrine; Foss, Nicolai B; Svensén, Christer

    2004-01-01

    BACKGROUND: The most common side effect of epidural or spinal anesthesia is hypotension with functional hypovolemia prompting fluid infusions or administration of vasopressors. Short-term studies (20 min) in patients undergoing lumbar epidural anesthesia suggest that plasma volume may increase when...... hypotension is present, which may have implications for the choice of treatment of hypotension. However, no long-term information or measurements of plasma volumes with or without hypotension after epidural anesthesia are available. METHODS: In 12 healthy volunteers, the authors assessed plasma (125I...... receiving hydroxyethyl starch. RESULTS: Plasma volume did not change per se after thoracic epidural anesthesia despite a decrease in blood pressure. Plasma volume increased with fluid administration but remained unchanged with vasopressors despite that both treatments had similar hemodynamic effects...

  1. Analysis of dynamic changes in the proteome of a Bcl-XL overexpressing Chinese hamster ovary cell culture during exponential and stationary phases.

    Science.gov (United States)

    Carlage, Tyler; Kshirsagar, Rashmi; Zang, Li; Janakiraman, Vijay; Hincapie, Marina; Lyubarskaya, Yelena; Weiskopf, Andy; Hancock, William S

    2012-01-01

    Mammalian cell cultures used for biopharmaceutical production undergo various dynamic biological changes over time, including the transition of cells from an exponential growth phase to a stationary phase during cell culture. To better understand the dynamic aspects of cell culture, a quantitative proteomics approach was used to identify dynamic trends in protein expression over the course of a Chinese hamster ovary (CHO) cell culture for the production of a recombinant monoclonal antibody and overexpressing the antiapoptotic gene Bcl-xl. Samples were analyzed using a method incorporating iTRAQ labeling, two-dimensional LC/MS, and linear regression calculations to identify significant dynamic trends in protein abundance. Using this approach, 59 proteins were identified with significant temporal changes in expression. Pathway analysis tools were used to identify a putative network of proteins associated with cell growth and apoptosis. Among the differentially expressed proteins were molecular chaperones and isomerases, such as GRP78 and PDI, and reported cell growth markers MCM2 and MCM5. In addition, two proteins with growth-regulating properties, transglutaminase-2 and clusterin, were identified. These proteins are associated with tumor proliferation and apoptosis and were observed to be expressed at relatively high levels during stationary phase, which was confirmed by western blotting. The proteomic methodology described here provides a dynamic view of protein expression throughout a CHO fed-batch cell culture, which may be useful for further elucidating the biological processes driving mammalian cell culture performance. Copyright © 2012 American Institute of Chemical Engineers (AIChE).

  2. Deterioration of abstract reasoning ability in mild cognitive impairment and Alzheimer's disease: correlation with regional grey matter volume loss revealed by diffeomorphic anatomical registration through exponentiated lie algebra analysis

    Energy Technology Data Exchange (ETDEWEB)

    Yoshiura, Takashi; Hiwatashi, Akio; Yamashita, Koji; Takayama, Yukihisa; Kamano, Norihiro; Honda, Hiroshi [Kyushu University, Department of Clinical Radiology, Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka (Japan); Ohyagi, Yasumasa; Kira, Jun-ichi [Kyushu University, Department of Neurology, Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka (Japan); Monji, Akira; Kawashima, Toshiro [Kyushu University, Department of Neuropsychiatry, Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka (Japan)

    2011-02-15

    To determine which brain regions are relevant to deterioration in abstract reasoning as measured by Raven's Colored Progressive Matrices (CPM) in the context of dementia. MR images of 37 consecutive patients including 19 with Alzheimer's disease (AD) and 18 with amnestic mild cognitive impairment (aMCI) were retrospectively analyzed. All patients were administered the CPM. Regional grey matter (GM) volume was evaluated according to the regimens of voxel-based morphometry, during which a non-linear registration algorithm called Diffeomorphic Anatomical Registration Through Exponentiated Lie algebra was employed. Multiple regression analyses were used to map the regions where GM volumes were correlated with CPM scores. The strongest correlation with CPM scores was seen in the left middle frontal gyrus while a region with the largest volume was identified in the left superior temporal gyrus. Significant correlations were seen in 14 additional regions in the bilateral cerebral hemispheres and right cerebellum. Deterioration of abstract reasoning ability in AD and aMCI measured by CPM is related to GM loss in multiple regions, which is in close agreement with the results of previous activation studies. (orig.)

  3. Deterioration of abstract reasoning ability in mild cognitive impairment and Alzheimer's disease: correlation with regional grey matter volume loss revealed by diffeomorphic anatomical registration through exponentiated lie algebra analysis.

    Science.gov (United States)

    Yoshiura, Takashi; Hiwatashi, Akio; Yamashita, Koji; Ohyagi, Yasumasa; Monji, Akira; Takayama, Yukihisa; Kamano, Norihiro; Kawashima, Toshiro; Kira, Jun-Ichi; Honda, Hiroshi

    2011-02-01

    To determine which brain regions are relevant to deterioration in abstract reasoning as measured by Raven's Colored Progressive Matrices (CPM) in the context of dementia. MR images of 37 consecutive patients including 19 with Alzheimer's disease (AD) and 18 with amnestic mild cognitive impairment (aMCI) were retrospectively analyzed. All patients were administered the CPM. Regional grey matter (GM) volume was evaluated according to the regimens of voxel-based morphometry, during which a non-linear registration algorithm called Diffeomorphic Anatomical Registration Through Exponentiated Lie algebra was employed. Multiple regression analyses were used to map the regions where GM volumes were correlated with CPM scores. The strongest correlation with CPM scores was seen in the left middle frontal gyrus while a region with the largest volume was identified in the left superior temporal gyrus. Significant correlations were seen in 14 additional regions in the bilateral cerebral hemispheres and right cerebellum. Deterioration of abstract reasoning ability in AD and aMCI measured by CPM is related to GM loss in multiple regions, which is in close agreement with the results of previous activation studies.

  4. KCNQ1 channels sense small changes in cell volume

    DEFF Research Database (Denmark)

    Grunnet, Morten; Jespersen, Thomas; MacAulay, Nanna

    2003-01-01

    . Incubation of the oocytes in cytochalasin D and experiments with truncated KCNQ1 channels suggest that KCNQ1 channels sense cell volume changes through interactions between the cytoskeleton and the N-terminus of the channel protein. From our results we propose that KCNQ1 and KCNQ4 channels play an important...

  5. Volume Changes in Filled Rubber Under Uniaxial Cyclic Loading

    Directory of Open Access Journals (Sweden)

    Elina KAZINA

    2011-09-01

    Full Text Available Styrene-butadiene rubber, neat and filled with different silica content was investigated under uniaxial cyclic loading under a constant crosshead speed, with increasing deformation amplitude in subsequent loading cycles. Rubber was investigated in order to evaluate the reversibility of structure rearrangements, occurring in rubber when subjected to cyclic loading. Volume uniformly increases with growing strain and shows hysteresis at unloading. After complete unloading, no residual strain changes are observed. These data are in good conformity with the data of density measurements, which were made on specimens before and after the tests. By correlating data, obtained from volume changes and kinetics of hysteresis losses there were made assumptions on deformation mechanisms at different elongations. Deformational mechanisms, responsible for volume changes in rubber are reversible. Volume changes in specimen occur due to voids formation caused by filler microstructure breakage, rubber chains disentanglement, spaces between rubber macromolecular chains shrinkage, and chain slippage under higher elongations. Voids formation and deformation of rubber macromolecular chain reaches equilibrium state after certain elongation.http://dx.doi.org/10.5755/j01.ms.17.3.592

  6. White matter volume change and its correlation with symptom severity in patients with schizophrenia: a VBM-DARTEL study.

    Science.gov (United States)

    Kim, Gwang-Won; Jeong, Gwang-Woo

    2015-12-16

    The aim of this study was to evaluate the white matter (WM) volume change and its correlation with symptom severity in patients with schizophrenia using voxel-based morphometry. A total of 20 patients with schizophrenia and 20 age-matched healthy controls participated in this study. MR image data were processed using SPM8 software with diffeomorphic anatomical registration through an exponentiated Lie algebra (DARTEL) algorithm. The patients with schizophrenia showed significant decreases (P=0.042) in the WM volumes of the temporal lobe and superior frontal gyrus compared with the healthy controls. The WM volumes of the middle temporal gyrus were negatively correlated with the scores of both the Positive Subscale (Pearson's ρ=-0.68, P=0.001) and the Negative Subscale (ρ=-0.71, P=0.0005) in the Positive and Negative Syndrome Scale. In addition, the scores of the General Psychopathology Subscale were negatively correlated with the WM volumes of the superior frontal gyrus (ρ=-0.68, P=0.0009). This study evaluated the WM volume of patients with schizophrenia compared with healthy controls using DARTEI-based voxel-based morphometry and also assessed the correlation of the localized WM volume changes with the Positive and Negative Syndrome Scale. These findings will be useful to understand the neuropathology associated with WM abnormality in schizophrenia.

  7. Acute plasma volume change with high-intensity sprint exercise.

    Science.gov (United States)

    Bloomer, Richard J; Farney, Tyler M

    2013-10-01

    When exercise is of long duration or of moderate to high intensity, a decrease in plasma volume can be observed. This has been noted for both aerobic and resistance exercise, but few data are available with regard to high-intensity sprint exercise. We measured plasma volume before and after 3 different bouts of acute exercise, of varying intensity, and/or duration. On different days, men (n = 12; 21-35 years) performed aerobic cycle exercise (60 minutes at 70% heart rate reserve) and 2 different bouts of cycle sprints (five 60-second sprints at 100% maximum wattage obtained during graded exercise testing (GXT) and ten 15-second sprints at 200% maximum wattage obtained during GXT). Blood was collected before and 0, 30, and 60 minutes postexercise and analyzed for hematocrit and hemoglobin and plasma volume was calculated. Plasma volume decreased significantly for all exercise bouts (p sprint bouts (∼19%) compared with aerobic exercise bouts (∼11%). By 30 minutes postexercise, plasma volume approached pre-exercise values. We conclude that acute bouts of exercise, in particular high-intensity sprint exercise, significantly decrease plasma volume during the immediate postexercise period. It is unknown what, if any negative implications these transient changes may have on exercise performance. Strength and conditioning professionals may aim to rehydrate athletes appropriately after high-intensity exercise bouts.

  8. Methods of Fast Exponentiation

    Directory of Open Access Journals (Sweden)

    Mohammed A. Maitah

    2010-01-01

    Full Text Available Problem statement: Modular exponentiation constitutes the basis of many well-known and widely used public key cryptosystems. Approach: A fast portable modular exponentiation algorithm considerably enhanced the speed and applicability of these systems, also an efficient implementation of this algorithm was the key to high performance of such system. Results: In this study, two main approaches for solving this problem were proposed. The proposed approaches involved calculations without usage of extra operational memory for saving constants and calculations with usage of preliminary calculated constants. Conclusion/Recommendations: The estimation of complexity of the speedup and effectiveness of proposed approaches for the data were presented.

  9. Volume changes in glass induced by an electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Gavenda, Tadeáš, E-mail: gavendat@vscht.cz [Department of Glass and Ceramics, Institute of Chemical Technology, Technická 5, CZ-166 28 Prague (Czech Republic); Gedeon, Ondrej [Department of Glass and Ceramics, Institute of Chemical Technology, Technická 5, CZ-166 28 Prague (Czech Republic); Jurek, Karel [Institute of Physics, Academy of the Czech Republic, Na Slovance 2, CZ-182 21 Prague (Czech Republic)

    2014-03-01

    Three glasses (float, borosilicate float and Schott D263 glasses) were irradiated by 50 keV electron beams with doses within the range of 0.21–318.5 kC/m{sup 2}. Volume changes induced by electron bombarding were monitored by means of Atomic Force Microscopy. Incubation doses, related to mobility of alkali ions, were measured. Low doses showed compaction of all glasses while higher doses revealed volume inflation, except for borosilicate float glass. Both surfaces of float glass were irradiated and significant differences between them were found.

  10. Volume changes in glass induced by an electron beam

    Science.gov (United States)

    Gavenda, Tadeáš; Gedeon, Ondrej; Jurek, Karel

    2014-03-01

    Three glasses (float, borosilicate float and Schott D263 glasses) were irradiated by 50 keV electron beams with doses within the range of 0.21-318.5 kC/m2. Volume changes induced by electron bombarding were monitored by means of Atomic Force Microscopy. Incubation doses, related to mobility of alkali ions, were measured. Low doses showed compaction of all glasses while higher doses revealed volume inflation, except for borosilicate float glass. Both surfaces of float glass were irradiated and significant differences between them were found.

  11. Comparing exponential and exponentiated models of drug demand in cocaine users.

    Science.gov (United States)

    Strickland, Justin C; Lile, Joshua A; Rush, Craig R; Stoops, William W

    2016-12-01

    Drug purchase tasks provide rapid and efficient measurement of drug demand. Zero values (i.e., prices with zero consumption) present a quantitative challenge when using exponential demand models that exponentiated models may resolve. We aimed to replicate and advance the utility of using an exponentiated model by demonstrating construct validity (i.e., association with real-world drug use) and generalizability across drug commodities. Participants (N = 40 cocaine-using adults) completed Cocaine, Alcohol, and Cigarette Purchase Tasks evaluating hypothetical consumption across changes in price. Exponentiated and exponential models were fit to these data using different treatments of zero consumption values, including retaining zeros or replacing them with 0.1, 0.01, or 0.001. Excellent model fits were observed with the exponentiated model. Means and precision fluctuated with different replacement values when using the exponential model but were consistent for the exponentiated model. The exponentiated model provided the strongest correlation between derived demand intensity (Q0) and self-reported free consumption in all instances (Cocaine r = .88; Alcohol r = .97; Cigarette r = .91). Cocaine demand elasticity was positively correlated with alcohol and cigarette elasticity. Exponentiated parameters were associated with real-world drug use (e.g., weekly cocaine use) whereas these correlations were less consistent for exponential parameters. Our findings show that selection of zero replacement values affects demand parameters and their association with drug-use outcomes when using the exponential model but not the exponentiated model. This work supports the adoption of the exponentiated demand model by replicating improved fit and consistency and demonstrating construct validity and generalizability. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  12. Toward optimal organ at risk sparing in complex volumetric modulated arc therapy: An exponential trade-off with target volume dose homogeneity

    Energy Technology Data Exchange (ETDEWEB)

    Tol, Jim P., E-mail: j.tol@vumc.nl; Dahele, Max; Doornaert, Patricia; Slotman, Ben J.; Verbakel, Wilko F. A. R. [Department of Radiation Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam (Netherlands)

    2014-02-15

    Purpose: Conventional radiotherapy typically aims for homogenous dose in the planning target volume (PTV) while sparing organs at risk (OAR). The authors quantified and characterized the trade-off between PTV dose inhomogeneity (IH) and OAR sparing in complex head and neck volumetric modulated arc therapy plans. Methods: Thirteen simultaneous integrated boost plans were created per patient, for ten patients. PTV boost{sub (B)}/elective{sub (E)} optimization priorities were systematically increased. IH{sub B} and IH{sub E}, defined as (100% − V95%) + V107%, were evaluated against the average of the mean dose to the combined composite swallowing and combined salivary organs (D-OAR{sub comp}). To investigate the influence of OAR size and position with respect to PTV{sub B/E}, OAR dose was evaluated against a modified Euclidean distance (DM{sub B}/DM{sub E}) between OAR and PTV. Results: Although the achievable D-OAR{sub comp} for a given level of PTV IH differed between patients, excellent logarithmic fits described the D-OAR{sub comp}/IH{sub B} and IH{sub E} relationship in all patients (mean R{sup 2} of 0.98 and 0.97, respectively). Allowing an increase in average IH{sub B} and IH{sub E} over a clinically acceptable range, e.g., from 0.4% ± 0.5% to 2.0% ± 2.0% and 6.9% ± 2.8% to 14.8% ± 2.7%, respectively, corresponded to a decrease in average dose to the composite salivary and swallowing structures from 30.3 ± 6.5 to 23.6 ± 4.7 Gy and 32.5 ± 8.3 to 26.8 ± 9.3 Gy. The increase in PTV{sub E} IH was mainly accounted for by an increase in V107, by on average 5.9%, rather than a reduction in V95, which was on average only 2%. A linear correlation was found between the OAR dose to composite swallowing structures and contralateral parotid and submandibular gland, with DM{sub E} (R{sup 2} = 0.83, 0.88, 0.95). Only mean ipsilateral parotid dose correlated with DM{sub B} (R{sup 2} = 0.87). Conclusions: OAR sparing is highly dependent on the permitted PTV{sub B

  13. Density assumptions for converting geodetic glacier volume change to mass change

    Directory of Open Access Journals (Sweden)

    M. Huss

    2013-05-01

    Full Text Available The geodetic method is widely used for assessing changes in the mass balance of mountain glaciers. However, comparison of repeated digital elevation models only provides a glacier volume change that must be converted to a change in mass using a density assumption or model. This study investigates the use of a constant factor for the volume-to-mass conversion based on a firn compaction model applied to simplified glacier geometries with idealized climate forcing, and two glaciers with long-term mass balance series. It is shown that the "density" of geodetic volume change is not a constant factor and is systematically smaller than ice density in most cases. This is explained by the accretion/removal of low-density firn layers, and changes in the firn density profile with positive/negative mass balance. Assuming a value of 850 ± 60 kg m−3 to convert volume change to mass change is appropriate for a wide range of conditions. For short time intervals (≤3 yr, periods with limited volume change, and/or changing mass balance gradients, the conversion factor can however vary from 0–2000 kg m−3 and beyond, which requires caution when interpreting glacier mass changes based on geodetic surveys.

  14. Band broadening studies using the parameters for an exponentially modified Gaussian

    Energy Technology Data Exchange (ETDEWEB)

    Pauls, R. E.; Rogers, L. B.

    1976-09-01

    The effects on chromatographic peak shape of dead volume and flow rate have been examined using the standard deviation of the Gaussian component of the peak and the exponential decay constant. For a non-retained solute, addition of dead volume led to an increase in the standard deviation that was independent of flow rate while the decay constant was inversely proportional to the flow. Smaller changes were observed for a retained species.

  15. Measurement of cell volume changes by fluorescence self-quenching

    DEFF Research Database (Denmark)

    Hamann, Steffen; Kiilgaard, J.F.; Litman, Thomas

    2002-01-01

    At high concentrations, certain fluorophores undergo self-quenching, i.e., fluorescence intensity decreases with increasing fluorophore concentration. Accordingly, the self-quenching properties can be used for measuring water volume changes in lipid vesicles. In cells, quantitative determination...... of water transport using fluorescence self-quenching has been complicated by the requirement of relatively high (mM) and often toxic loading concentrations. Here we report a simple method that uses low (muM) loading concentrations of calcein-acetoxymethyl ester (calcein-AM) to obtain intracellular...... concentrations of the fluorophore calcein suitable for measurement of changes in cell water volume by self-quenching. The relationship between calcein fluorescence intensity, when excited at 490 nm (its excitation maximum), and calcein concentration was investigated in vitro and in various cultured cell types...

  16. Collapsibility and Volume Change Behavior of Unsaturated Residual Soil

    Directory of Open Access Journals (Sweden)

    Azalan A. Aziz

    2006-01-01

    Full Text Available Residual soils occur in most countries of the world but the greater areas and depths are normally found in tropical humid areas. In these places, the soil forming processes are still very active and the weathering development is much faster than the erosive factor. Most residual soil exhibit high suctions for most of the year. The absence of positive pore water pressure except immediately after rain, makes conventional soil mechanics for saturated soil not so relevant. Ignorance or lack of understanding of the geotechnical behavior of soil in the partially or unsaturated state has caused a lot of damages to infrastructures, buildings and other structures. For instance, the collapsibility and volume change of partially saturated soils in connection with the drying or wetting causes a lot of damage in foundation, roads and other structures. It is also observed that many shallow slope failures involve a slumping (collapse type of failure. As such, the development of extended soil mechanics, which embraces the soil in the unsaturated state or subjected to soil suction, is essential. This study examines the collapsibility and volume change behavior specifically of an unsaturated residual soil under various levels of applied matric suction (ua-uw and net mean stress (σ-ua in a predetermined stress path. The volume change of the soil is found to be sensitive to both the applied matric suction and net mean stress. The soil is found to exhibit a collapsibility behavior upon a reduction in applied matric suction at constant net mean stress.

  17. Uniform Exponential Growth in Algebras /

    OpenAIRE

    Briggs, Christopher Alan

    2013-01-01

    We consider uniform exponential growth in algebras. We give conditions for the uniform exponential growth of descending-filtered algebras and prove that an N-graded algebra has uniform exponential growth if it has exponential growth. We use this to prove that Golod- Shafarevich algebras and group algebras of Golod- Shafarevich groups have uniform exponential growth. We prove that the twisted Laurent extension of a free commutative polynomial algebra with respect to an endomorphism with some e...

  18. Estimating exponential scheduling preferences

    DEFF Research Database (Denmark)

    Hjorth, Katrine; Börjesson, Maria; Engelson, Leonid

    time by maximising expected total utility over the day, their departure times are conditional on rates of utility derived at these locations. For forecasting and economic evaluation of planning alternatives, it is desirable to have simple forms of utility rates with few parameters. Several forms...... the travel time is random, Noland and Small (1995) suggested using expected utility theory to derive the reduced form of expected travel time cost that includes the cost of TTV. For the α-β-γ formulation of scheduling preferences and exponential or uniform distribution of travel time, Noland and Small (1995....... The purpose of this paper is to explore how well these scheduling preferences explain behaviour, compared to other possible scheduling models, and whether empirical estimation of the more complex exponential scheduling preferences is feasible. We use data from a stated preference survey conducted among car...

  19. Estimating exponential scheduling preferences

    DEFF Research Database (Denmark)

    Hjorth, Katrine; Börjesson, Maria; Engelson, Leonid

    time by maximising expected total utility over the day, their departure times are conditional on rates of utility derived at these locations. For forecasting and economic evaluation of planning alternatives, it is desirable to have simple forms of utility rates with few parameters. Several forms...... the travel time is random, Noland and Small (1995) suggested using expected utility theory to derive the reduced form of expected travel time cost that includes the cost of TTV. For the α-β-γ formulation of scheduling preferences and exponential or uniform distribution of travel time, Noland and Small (1995....... The purpose of this paper is to explore how well these scheduling preferences explain behaviour, compared to other possible scheduling models, and whether empirical estimation of the more complex exponential scheduling preferences is feasible. We use data from a stated preference survey conducted among car...

  20. Exponential random graph models

    CERN Document Server

    Fronczak, Agata

    2012-01-01

    Nowadays, exponential random graphs (ERGs) are among the most widely-studied network models. Different analytical and numerical techniques for ERG have been developed that resulted in the well-established theory with true predictive power. An excellent basic discussion of exponential random graphs addressed to social science students and researchers is given in [Anderson et al., 1999][Robins et al., 2007]. This essay is intentionally designed to be more theoretical in comparison with the well-known primers just mentioned. Given the interdisciplinary character of the new emerging science of complex networks, the essay aims to give a contribution upon which network scientists and practitioners, who represent different research areas, could build a common area of understanding.

  1. Brain-volume changes in young and middle-aged smokers: a DARTEL-based voxel-based morphometry study.

    Science.gov (United States)

    Peng, Peng; Wang, Zhenchang; Jiang, Tao; Chu, Shuilian; Wang, Shuangkun; Xiao, Dan

    2015-09-25

    Many studies have reported brain volume changes in smokers. However, the volume differences of grey matter (GM) and white matter (WM) in young and middle-aged male smokers with different lifetime tobacco consumption (pack-years) remain uncertain. To examine the brain volume change, especially whether more pack-years smoking would be associated with smaller gray matter and white matter volume in young and middle-aged male smokers. We used a 3T MR scanner and performed Diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL)-based voxel-based morphometry on 53 long-term male smokers (30.72 ± 4.19 years) and 53 male healthy non-smokers (30.83 ± 5.18 years). We separated smokers to light and heavy smokers by pack-years and compared brain volume between different smoker groups and non-smokers. And then we did analysis of covariance (ANCOVA) between smokers and non-smokers by setting pack-years as covariates. Light and heavy smokers all displayed smaller GM and WM volume than non-smokers and more obviously in heavy smokers. The main smaller areas in light and heavy smokers were superior temporal gyrus, insula, middle occipital gyrus, posterior cingulate, precuneus in GM and posterior cingulate, thalamus and midbrain in WM, in addition, we also observed more pack-years smoking was associated with some certain smaller GM and WM volumes by ANCOVA. Young and middle-aged male smokers had many smaller brain areas than non-smokers. Some of these areas' volume had negative correlation with pack-years, while some had not. These may due to different pathophysiological role of smokings. © 2015 John Wiley & Sons Ltd.

  2. Sea Level Change: Is the Volume of the Ocean Changing or Is It Redistributing?

    Science.gov (United States)

    Mitchum, G. T.; Thompson, P. R.; Merrifield, M. A.

    2012-12-01

    Global sea level change is due to changes in the ocean volume, which are in turn primarily due to changes in the globally averaged density of the ocean and ice melt from the land. Regional to local sea level changes reflect global changes as well as redistributions of volume due to ocean dynamics and land motions. Determining whether global sea level change is accelerating requires that we disentangle these regional and local signals from the true global volume changes. Given the current length of our time series determining acceleration is problematic, largely because of substantial spatial and temporal changes in the global sea level field due to ocean-atmosphere dynamics. We will review our work showing that global sea level reconstructions are sensitive to the weightings applied to the tide gauge data. We will also review basin-scale changes in sea level in the North Atlantic and the Tropical Pacific that are clearly wind-driven. These are important for two reasons. First, these signals mask the (presently) small global signal, and second, these signals present a statistical challenge for determining the acceleration of the global volume change rate. The obvious question is how well we can expect to estimate the sea level rise acceleration rate given the observed red noise character, in time and space, of the volume redistribution signals. We will end the presentation with various simulations of our ability to determine global sea level change acceleration that take into account reasonable estimates of decadal redistributions of ocean volume. The net result is that most recent attempts to determine acceleration are seriously flawed. On the positive side, we will provide estimates of how long it might take to make more reliable estimates.

  3. Possibilistic Exponential Fuzzy Clustering

    Institute of Scientific and Technical Information of China (English)

    Kiatichai Treerattanapitak; Chuleerat Jaruskulchai

    2013-01-01

    Generally,abnormal points (noise and outliers) cause cluster analysis to produce low accuracy especially in fuzzy clustering.These data not only stay in clusters but also deviate the centroids from their true positions.Traditional fuzzy clustering like Fuzzy C-Means (FCM) always assigns data to all clusters which is not reasonable in some circumstances.By reformulating objective function in exponential equation,the algorithm aggressively selects data into the clusters.However noisy data and outliers cannot be properly handled by clustering process therefore they are forced to be included in a cluster because of a general probabilistic constraint that the sum of the membership degrees across all clusters is one.In order to improve this weakness,possibilistic approach relaxes this condition to improve membership assignment.Nevertheless,possibilistic clustering algorithms generally suffer from coincident clusters because their membership equations ignore the distance to other clusters.Although there are some possibilistic clustering approaches that do not generate coincident clusters,most of them require the right combination of multiple parameters for the algorithms to work.In this paper,we theoretically study Possibilistic Exponential Fuzzy Clustering (PXFCM) that integrates possibilistic approach with exponential fuzzy clustering.PXFCM has only one parameter and not only partitions the data but also filters noisy data or detects them as outliers.The comprehensive experiments show that PXFCM produces high accuracy in both clustering results and outlier detection without generating coincident problems.

  4. Density assumptions for converting geodetic glacier volume change to mass change

    Directory of Open Access Journals (Sweden)

    M. Huss

    2013-01-01

    Full Text Available The geodetic method is widely used for assessing changes in the mass balance of mountain glaciers. However, comparison of repeated digital elevation models only provides a glacier volume change that must be converted to a change in mass using a density assumption. This study investigates this conversion factor based on a firn compaction model applied to simplified glacier geometries with idealized climate forcing, and two glaciers with long-term mass balance series. It is shown that the "density" of geodetic volume change is not a constant factor and is systematically smaller than ice density in most cases. This is explained by the accretion/removal of low-density firn layers, and changes in the firn density profile with positive/negative mass balance. Assuming a value of 850 ± 60 kg m−3 to convert volume change to mass change is appropriate for a wide range of conditions. For short time intervals (≤3 yr, periods with limited volume change, and/or changing mass balance gradients, the conversion factor can however vary from 0–2000 kg m−3 and beyond which requires caution when interpreting glacier mass changes based on geodetic surveys.

  5. Changes in plasma volume and baroreflex function following resistance exercise

    Science.gov (United States)

    Ploutz, L. L.; Tatro, D. L.; Dudley, G. A.; Convertino, V. A.

    1993-01-01

    The dynamics of change in plasma volume (PV) and baroreflex responses have been reported over 24 h immediately following maximal cycle exercise. The purpose of this study was to determine if PV and baroreflex showed similar changes for 24 h after resistance exercise. Eight men were studied on 2 test days, 1 week apart. On 1 day, per cent change (% delta) in PV was estimated at 0,3, and 6 h after resistance exercise using haematocrit and haemoglobin. Baseline PV was measured 24 h after exercise using Evans blue dye. The carotid baroreceptor-cardiac reflex response was measured before, and 3, 6, 9, 12, and 24 h post-exercise. Each subject performed six sets of the bench press and leg press with 10 repetitions per set with a load that induced failure within each set. On a control day, the protocol was used without exercise. Plasma volume did not change during the control day. There was a 20% decrease in PV immediately post-exercise; the recovery of the PV was rapid and complete within 3 h. PV was 20% greater 24 h post-exercise than on the control day. There were no differences in any of the baroreflex measurements. Therefore, it is suggested that PV shifts may occur without altering baroreflex sensitivity.

  6. Listening to PS II: enthalpy, entropy, and volume changes.

    Science.gov (United States)

    Hou, Harvey J M; Mauzerall, David

    2011-01-01

    Photosystem II, located in the thylakoid membranes of green plants, algae, and cyanobacteria, uses sunlight to split water into protons, electrons, and a dioxygen molecule. The mechanism of its electron transfers and oxygen evolution including the structure of the protein and rates of the S-state cycle has been extensively investigated. Substantial progress has been made; however, the thermodynamics of PS II electron transfer and of the oxygen cycle are poorly understood. Recent progress in thermodynamic measurements in photosynthesis provides novel insights on the enthalpic and entropic contribution to electron transfer in proteins. In this review the thermodynamic parameters including quantum yield, enthalpy, entropy, and volume changes of PS II photochemistry determined by photoacoustics and other laser techniques are summarized and evaluated. Light-driven volume changes via electrostriction are directly related to the photoreaction in PS II and thus can be a useful measurement of PS II activity and function. The enthalpy changes of the reactions observed can be directly measured by photoacoustics. The apparent reaction entropy can also be estimated when the free energy is known. Dissecting the free energy of a photoreaction into enthalpic and entropic components provides critical information about mechanisms of PS II function. Potential limitations and future direction of the study of the thermodynamics of PS II electron transfer and oxygen evolution are presented.

  7. Ordered exponential fields

    CERN Document Server

    Kuhlmann, Salma

    1999-01-01

    Model theoretic algebra has witnessed remarkable progress in the last few years. It has found profound applications in other areas of mathematics, notably in algebraic geometry and in singularity theory. Since Wilkie's results on the o-minimality of the expansion of the reals by the exponential function, and most recently even by all Pfaffian functions, the study of o-minimal expansions of the reals has become a fascinating topic. The quest for analogies between the semi-algebraic case and the o-minimal case has set a direction to this research. Through the Artin-Schreier Theory of real closed

  8. Comparative changes in plasma protein concentration, hematocrit and plasma volume during exercise, bedrest and + Gz acceleration.

    Science.gov (United States)

    Van Beaumont, W.; Greenleaf, J. E.

    1972-01-01

    Discussion of experiments which indicate that under conditions of a constant red cell volume the proportional changes in hematocrit and plasma volume during exercise are never equal. On the basis of direct measurements and calculated changes of plasma volume it is concluded that during maximal exercise there is a small loss of protein from the plasma. It is clear that changes in content of blood constituents can only be evaluated correctly after determination of changes in plasma volume.

  9. Exponential Cauchy Transforms

    Directory of Open Access Journals (Sweden)

    El-Bachir Yallaoui

    2012-06-01

    Full Text Available In this article, we introduce a new class of analytic functions of the unit disc $mathbf{D}$ namely the Exponential Cauchy Transforms $mathbf{{K}_{e}}$ defined by f(z= {displaystyleint_{mathbf{T}}} expleft[ Kleft( xzight ight] dmu(x where $Kleft( zight =left( 1-zight ^{-1}$ is classical Cauchy kernel and $mu(x$ is a complex Borel measures and $x$ belongs to the unit circle $mathbf{T}$ . We use Laguerre polynomials to explore the coefficients of the Taylor expansions of the kernel and Peron's formula to study the asymptotic behavior of the Taylor coefficients. Finally we investigate relationships between our new class $mathbf{{K}_{e}}$, the classical Cauchy space $mathbf{K}$ and the Hardy spaces $H^{p}$.

  10. Noise in Exponential Growth

    Science.gov (United States)

    Iyer-Biswas, Srividya; Wright, Charles; Henry, Jon; Burov, Stas; Lin, Yihan; Crosson, Sean; Dinner, Aaron; Scherer, Norbert

    2013-03-01

    The interplay between growth and division of cells is has been studied in the context of exponential growth of bacterial cells (in suitable conditions) for decades. However, bulk culture studies obscure phenomena that manifest in single cells over many generations. We introduce a unique technology combining microfluidics, single-cell imaging, and quantitative analysis. This enables us to track the growth of single Caulobacter crescentus stalked cells over hundreds of generations. The statistics that we extract indicate a size thresholding mechanism for cell division and a non-trivial scaling collapse of division time distributions at different temperatures. In this talk I shall discuss these observations and a stochastic model of growth and division that captures all our observations with no free parameters.

  11. Beach Volume Change Using Uav Photogrammetry Songjung Beach, Korea

    Science.gov (United States)

    Yoo, C. I.; Oh, T. S.

    2016-06-01

    Natural beach is controlled by many factors related to wave and tidal forces, wind, sediment, and initial topography. For this reason, if numerous topographic data of beach is accurately collected, coastal erosion/acceleration is able to be assessed and clarified. Generally, however, many studies on coastal erosion have limitation to analyse the whole beach, carried out of partial area as like shoreline (horizontal 2D) and beach profile (vertical 2D) on account of limitation of numerical simulation. This is an important application for prevention of coastal erosion, and UAV photogrammetry is also used to 3D topographic data. This paper analyses the use of unmanned aerial vehicles (UAV) to 3D map and beach volume change. UAV (Quadcopter) equipped with a non-metric camera was used to acquire images in Songjung beach which is located south-east Korea peninsula. The dynamics of beach topography, its geometric properties and estimates of eroded and deposited sand volumes were determined by combining elevation data with quarterly RTK-VRS measurements. To explore the new possibilities for assessment of coastal change we have developed a methodology for 3D analysis of coastal topography evolution based on existing high resolution elevation data combined with low coast, UAV and on-ground RTK-VRS surveys. DSMs were obtained by stereo-matching using Agisoft Photoscan. Using GCPs the vertical accuracy of the DSMs was found to be 10 cm or better. The resulting datasets were integrated in a local coordinates and the method proved to be a very useful fool for the detection of areas where coastal erosion occurs and for the quantification of beach change. The value of such analysis is illustrated by applications to coastal of South Korea sites that face significant management challenges.

  12. BEACH VOLUME CHANGE USING UAV PHOTOGRAMMETRY SONGJUNG BEACH, KOREA

    Directory of Open Access Journals (Sweden)

    C. I. Yoo

    2016-06-01

    Full Text Available Natural beach is controlled by many factors related to wave and tidal forces, wind, sediment, and initial topography. For this reason, if numerous topographic data of beach is accurately collected, coastal erosion/acceleration is able to be assessed and clarified. Generally, however, many studies on coastal erosion have limitation to analyse the whole beach, carried out of partial area as like shoreline (horizontal 2D and beach profile (vertical 2D on account of limitation of numerical simulation. This is an important application for prevention of coastal erosion, and UAV photogrammetry is also used to 3D topographic data. This paper analyses the use of unmanned aerial vehicles (UAV to 3D map and beach volume change. UAV (Quadcopter equipped with a non-metric camera was used to acquire images in Songjung beach which is located south-east Korea peninsula. The dynamics of beach topography, its geometric properties and estimates of eroded and deposited sand volumes were determined by combining elevation data with quarterly RTK-VRS measurements. To explore the new possibilities for assessment of coastal change we have developed a methodology for 3D analysis of coastal topography evolution based on existing high resolution elevation data combined with low coast, UAV and on-ground RTK-VRS surveys. DSMs were obtained by stereo-matching using Agisoft Photoscan. Using GCPs the vertical accuracy of the DSMs was found to be 10 cm or better. The resulting datasets were integrated in a local coordinates and the method proved to be a very useful fool for the detection of areas where coastal erosion occurs and for the quantification of beach change. The value of such analysis is illustrated by applications to coastal of South Korea sites that face significant management challenges.

  13. Size and sequence and the volume change of protein folding.

    Science.gov (United States)

    Rouget, Jean-Baptiste; Aksel, Tural; Roche, Julien; Saldana, Jean-Louis; Garcia, Angel E; Barrick, Doug; Royer, Catherine A

    2011-04-20

    The application of hydrostatic pressure generally leads to protein unfolding, implying, in accordance with Le Chatelier's principle, that the unfolded state has a smaller molar volume than the folded state. However, the origin of the volume change upon unfolding, ΔV(u), has yet to be determined. We have examined systematically the effects of protein size and sequence on the value of ΔV(u) using as a model system a series of deletion variants of the ankyrin repeat domain of the Notch receptor. The results provide strong evidence in support of the notion that the major contributing factor to pressure effects on proteins is their imperfect internal packing in the folded state. These packing defects appear to be specifically localized in the 3D structure, in contrast to the uniformly distributed effects of temperature and denaturants that depend upon hydration of exposed surface area upon unfolding. Given its local nature, the extent to which pressure globally affects protein structure can inform on the degree of cooperativity and long-range coupling intrinsic to the folded state. We also show that the energetics of the protein's conformations can significantly modulate their volumetric properties, providing further insight into protein stability.

  14. Do intravascular hypo- and hypervolaemia result in changes in central blood volumes?

    NARCIS (Netherlands)

    Vos, J. J.; Scheeren, T. W. L.; Loer, S. A.; Hoeft, A.; Wietasch, J. K. G.

    2016-01-01

    Background: Hypovolaemia is generally believed to induce centralization of blood volume. Therefore, we evaluated whether induced hypo-and hypervolaemia result in changes in central blood volumes (pulmonary blood volume (PBV), intrathoracic blood volume (ITBV)) and we explored the effects on the dist

  15. On exponentiable soft topological spaces

    Directory of Open Access Journals (Sweden)

    Ghasem Mirhosseinkhani

    2016-11-01

    Full Text Available An object $X$ of a category $mathbf{C}$ with finite limits is called exponentiable if the functor $-times X:mathbf{C}rightarrow mathbf{C}$ has a right adjoint. There are many characterizations of the exponentiable  spaces in the category $mathbf{Top}$ of topological spaces. Here, we study the exponentiable objects in the category $mathbf{STop}$ of soft topological spaces which is a generalization of the category  $mathbf{Top}$. We investigate  the exponentiability problem and give a characterization of exponentiable soft spaces. Also wegive the definition of exponential topology on the lattice of soft open sets of a soft space and present some characterizations of it.

  16. Study on Volume Strain Inversion from Water Level Change of Well-aquifer Systems

    Institute of Scientific and Technical Information of China (English)

    Yan Rui; Gao Fuwang; Chen Yong

    2008-01-01

    Based on linear poroelastic and hydrogcology theory, a mathematical expression describing the relationship between water level change and aquifer volume strain is put forward. Combined with earth tidal theory, we analyze the response characteristics from well-aquifer water level change to earth tide of volume strain and present a method of volume strain inversion from water level change. Comparing the results of inversion with real observed data, we found that there is a good consistency. This suggcsts that the method of volume strain inversion from water level change is proper. It will offer a reference for learning about hydrogeology characteristics, volume strain and searching for precursor anomalies.

  17. When Economic Growth is Less than Exponential

    DEFF Research Database (Denmark)

    Groth, Christian; Koch, Karl-Josef; Steger, Thomas M.

    This paper argues that growth theory needs a more general notion of "regularity" than that of exponential growth. We suggest that paths along which the rate of decline of the growth rate is proportional to the growth rate itself deserve attention. This opens up for considering a richer set...... of parameter combinations than in standard growth models. And it avoids the usual oversimplistic dichotomy of either exponential growth or stagnation. Allowing zero population growth in three different growth models (the Jones R&D-based model, a learning-by-doing model, and an embodied technical change model......) serve as illustrations that a continuum of "regular" growth processes fill the whole range between exponential growth and complete stagnation....

  18. Expectation Propagation for Exponential Families

    OpenAIRE

    Seeger, Matthias

    2005-01-01

    This is a tutorial describing the Expectation Propagation (EP) algorithm for a general exponential family. Our focus is on simplicity of exposition. Although the overhead of translating a specific model into its exponential family representation can be considerable, many apparent complications of EP can simply be sidestepped by working in this canonical representation.

  19. Multivariate Matrix-Exponential Distributions

    DEFF Research Database (Denmark)

    Bladt, Mogens; Nielsen, Bo Friis

    2010-01-01

    -exponential distributions. We prove a characterization that states that a distribution is an MVME distribution if and only if all non-negative, non-null linear combinations of the coordinates have a univariate matrix-exponential distribution. This theorem is analog to a well-known characterization theorem...

  20. Disproportional changes in hematocrit, plasma volume, and proteins during exercise and bed rest.

    Science.gov (United States)

    Van Beaumont, W.; Greenleaf, J. E.; Juhos, L.

    1972-01-01

    The interrelationships between the changes in plasma volume, hematocrit, and plasma proteins during muscular exercise and bed rest were investigated. Proportionally, the changes in hematocrit are always smaller than the changes in plasma volume. For this reason changes in the concentration of blood constituents can only be quantitated on the basis of plasma volume changes. During short periods of intensive exercise, there was a small loss of plasma proteins. With prolonged submaximal exercise there was a net gain in plasma protein, which contributes to stabilization of the vascular volume. Prolonged bed rest induced hypoproteinemia; this loss of plasma protein probably plays an important role in recumbency hypovolemia.

  1. Factors influencing liver and spleen volume changes after donor hepatectomy for living donor liver transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Ji Hee; Ryeom, Hunku; Song, Jung Hup [Kyungpook National University Hospital, Daegu (Korea, Republic of)

    2013-11-15

    To define the changes in liver and spleen volumes in the early postoperative period after partial liver donation for living-donor liver transplantation (LDLT) and to determine factors that influence liver and spleen volume changes. 27 donors who underwent partial hepatectomy for LDLT were included in this study. The rates of liver and spleen volume change, measured with CT volumetry, were correlated with several factors. The analyzed factors included the indocyanine green (ICG) retention rate at 15 minutes after ICG administration, preoperative platelet count, preoperative liver and splenic volumes, resected liver volume, resected-to-whole liver volume ratio (LV{sub R}/LV{sub W}), resected liver volume to the sum of whole liver and spleen volume ratio [LV{sub R}/(LV{sub W} + SV{sub 0})], and pre and post hepatectomy portal venous pressures. In all hepatectomy donors, the volumes of the remnant liver and spleen were increased (increased rates, 59.5 ± 50.5%, 47.9 ± 22.6%). The increment rate of the remnant liver volume revealed a positive correlation with LV{sub R}/LV{sub W} (r = 0.759, p < 0.01). The other analyzed factors showed no correlation with changes in liver and spleen volumes. The spleen and remnant liver volumes were increased at CT volumetry performed 2 weeks after partial liver donation. Among the various analyzed factors, LV{sub R}/LV{sub W} influences the increment rate of the remnant liver volume.

  2. VMAT-Mediated changes in quantal size and vesicular volume

    NARCIS (Netherlands)

    Colliver, T L; Pyott, S J; Achalabun, M; Ewing, A G

    2000-01-01

    It has been well established that the volume of secretory vesicles can be modulated. However, we present the first data demonstrating that the amount of transmitter in a vesicle can regulate its volume. Amperometry and transmission electron microscopy have been used to determine that l-3,4-dihydroxy

  3. Stability, Tunneling and Flux Changing de Sitter Transitions in the Large Volume String Scenario

    CERN Document Server

    de Alwis, S; Hatefi, E; Quevedo, F

    2013-01-01

    We study the non-perturbative stability of the Large Volume Scenario (LVS) of IIB string compactifications, by analysing transitions mediated by the Brown-Teitelboim (BT) brane nucleations and by Coleman De Luccia tunneling (CDL). We find that, as long as the effective field theory description holds, the LVS AdS minima are stable despite being non-supersymmetric. This opens the possibility of having a CFT dual. Metastable de Sitter vacua behave differently depending on the uplifting mechanism. We find explicit expressions for the different decay rates in terms of exponentials of the volume. Among the transitions of dS to dS those with increasing volume and decreasing vacuum energy are preferred, though dS decays to AdS (big-crunch sinks) have higher probability. Transitions via the CDL mechanism to decompactification are exponentially suppressed compared to these. The BT decays correspond to flux/D3 brane transitions mediated by the nucleation of D5/NS5 branes. We compare our results with previous analysis fo...

  4. STUDY ON COPOLYMER EPOXY RESIN MATRIX WITHOUT SHRINKAGE PART I VOLUME CHANGE DURING CURE PROCESSES

    Institute of Scientific and Technical Information of China (English)

    HE Pingsheng; ZHOU Zhiqiang; WANG Gengchao; PAN Caiyuan; WU Renjie

    1988-01-01

    The volume change of the copolymer epoxy resins can be controlled by copolymerizing epoxy resin E51 with 3,9-di (5-norbornene-2, 2)-1, 5, 7, 11-tetraoxaspiro [5, 5] undecane (NSOC). During curing,the volume changes of copolymer epoxy resins with various amounts of NSOC were measured with a dilatometer. Cure process does not produce volume change when epoxy resin E51: NSOC is 5.88: 1 in equivalent.

  5. Free Volume Changes in γ-Irradiated Polyethylene andPolytetraflourethylene

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Positron lifetime spectrum was measured and the change of the free volume was studied for commercial polyethylene (PE) and polytetrafluoroethylene (PTFE) during γ-irradiation processingup to 265 kGy. The free volume size increases but the crystallinity decreases as irradiation doseincreases in PE. Both qualities (free volume size and crystallinity) in PTFE display an oppositebehavior. The fractional free volume reduces monotonically with increasing irradiation dose inboth PE and PTFE. The competition between the crosslinking and the splitting decompositionin polymers can be used to understand the free volume changes with irradiation dose.

  6. Quantitative prediction of respiratory tidal volume based on the external torso volume change: a potential volumetric surrogate

    Energy Technology Data Exchange (ETDEWEB)

    Li Guang; Arora, Naveen C; Xie Huchen; Ning, Holly; Citrin, Deborah; Kaushal, Aradhana; Zach, Leor; Camphausen, Kevin; Miller, Robert W [Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (United States); Lu Wei; Low, Daniel [Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110 (United States)], E-mail: ligeorge@mail.nih.gov

    2009-04-07

    An external respiratory surrogate that not only highly correlates with but also quantitatively predicts internal tidal volume should be useful in guiding four-dimensional computed tomography (4DCT), as well as 4D radiation therapy (4DRT). A volumetric surrogate should have advantages over external fiducial point(s) for monitoring respiration-induced motion of the torso, which deforms in synchronization with a patient-specific breathing pattern. This study establishes a linear relationship between the external torso volume change (TVC) and lung air volume change (AVC) by validating a proposed volume conservation hypothesis (TVC = AVC) throughout the respiratory cycle using 4DCT and spirometry. Fourteen patients' torso 4DCT images and corresponding spirometric tidal volumes were acquired to examine this hypothesis. The 4DCT images were acquired using dual surrogates in cine mode and amplitude-based binning in 12 respiratory stages, minimizing residual motion artifacts. Torso and lung volumes were calculated using threshold-based segmentation algorithms and volume changes were calculated relative to the full-exhalation stage. The TVC and AVC, as functions of respiratory stages, were compared, showing a high correlation (r = 0.992 {+-} 0.005, p < 0.0001) as well as a linear relationship (slope = 1.027 {+-} 0.061, R{sup 2} = 0.980) without phase shift. The AVC was also compared to the spirometric tidal volumes, showing a similar linearity (slope = 1.030 {+-} 0.092, R{sup 2} = 0.947). In contrast, the thoracic and abdominal heights measured from 4DCT showed relatively low correlation (0.28 {+-} 0.44 and 0.82 {+-} 0.30, respectively) and location-dependent phase shifts. This novel approach establishes the foundation for developing an external volumetric respiratory surrogate.

  7. Evidence for super-exponentially accelerating atmospheric carbon dioxide growth

    CERN Document Server

    Hüsler, Andreas D

    2011-01-01

    We analyze the growth rates of atmospheric carbon dioxide and human population, by comparing the relative merits of two benchmark models, the exponential law and the finite-time-singular (FTS) power law. The later results from positive feedbacks, either direct or mediated by other dynamical variables, as shown in our presentation of a simple endogenous macroeconomic dynamical growth model. Our empirical calibrations confirm that human population has decelerated from its previous super-exponential growth until 1960 to ``just' an exponential growth, but with no sign of more deceleration. As for atmospheric CO2 content, we find that it is at least exponentially increasing and most likely characterized by an accelerating growth rate as off 2009, consistent with an unsustainable FTS power law regime announcing a drastic change of regime. The coexistence of a quasi-exponential growth of human population with a super-exponential growth of carbon dioxide content in the atmosphere is a diagnostic of insignificant impr...

  8. Demonstration of the exponential decay law using beer froth

    Energy Technology Data Exchange (ETDEWEB)

    Leike, A. [Ludwig-Maximilians-Universitaet, Sektion Physik, Munich (Germany)]. E-mail: leike@theorie.physik.uni-muenchen.de

    2002-01-01

    The volume of beer froth decays exponentially with time. This property is used to demonstrate the exponential decay law in the classroom. The decay constant depends on the type of beer and can be used to differentiate between different beers. The analysis shows in a transparent way the techniques of data analysis commonly used in science - consistency checks of theoretical models with the data, parameter estimation and determination of confidence intervals. (author)

  9. Is Radioactive Decay Really Exponential?

    CERN Document Server

    Aston, Philip J

    2012-01-01

    Radioactive decay of an unstable isotope is widely believed to be exponential. This view is supported by experiments on rapidly decaying isotopes but is more difficult to verify for slowly decaying isotopes. The decay of 14C can be calibrated over a period of 12,550 years by comparing radiocarbon dates with dates obtained from dendrochronology. It is well known that this approach shows that radiocarbon dates of over 3,000 years are in error, which is generally attributed to past variation in atmospheric levels of 14C. We note that predicted atmospheric variation (assuming exponential decay) does not agree with results from modelling, and that theoretical quantum mechanics does not predict exact exponential decay. We give mathematical arguments that non-exponential decay should be expected for slowly decaying isotopes and explore the consequences of non-exponential decay. We propose an experimental test of this prediction of non-exponential decay for 14C. If confirmed, a foundation stone of current dating meth...

  10. Generalized approach to non-exponential relaxation

    Indian Academy of Sciences (India)

    R M Pickup; R Cywinski; C Pappas; P Fouquet; B Farago; P Falus

    2008-11-01

    Non-exponential relaxation is a universal feature of systems as diverse as glasses, spin glasses, earthquakes, financial markets and the universe. Complex relaxation results from hierarchically constrained dynamics with the strength of the constraints being directly related to the form of the relaxation, which changes from a simple exponential to a stretched exponential and a power law by increasing the constraints in the system. A global and unified approach to non-exponentiality was first achieved by Weron and was further generalized by Brouers and Sotolongo-Costa, who applied the concept of non-extensive entropy introduced by Tsallis to the relaxation of disordered systems. These concepts are now confronted with experimental results on the classical metallic spin glasses CuMn, AuFe and the insulating system EuSrS. The revisited data have also be complemented by new results on several compositions of the classical CuMn spin glass and on systems, like CoGa and CuCo, the magnetic behaviour of which is believed to arise from magnetic clusters and should be characteristic for superparamagnetism.

  11. Implications of changing scattering properties on Greenland ice sheet volume change from Cryosat-2 altimetry

    DEFF Research Database (Denmark)

    Simonsen, Sebastian Bjerregaard; Sørensen, Louise Sandberg

    2017-01-01

    Long-term observations of surface elevation change of the Greenland ice sheet (GrIS) is of utmost importance when assessing the state of the ice sheet. Satellite radar altimetry offers a long time series of data over the GrIS, starting with ERS-1 in 1991. ESA's Cryosat-2 mission, launched in 2010...... waveform parameters to be applicable for correcting for changes in volume scattering. The best results in the Synthetic Aperture Radar Interferometric mode area of the GrIS are found when applying only the backscatter correction, whereas the best result in the Low Resolution Mode area is obtained by only...... applying a leading edge width correction. Using this approach to correct for the scattering properties, a volume loss of −292±38 km3 yr −1 is found for the GrIS for the time span November 2010 until November 2014. The inclusion of waveform parameter corrections and improved relocation for the GrIS, helps...

  12. Development of a finite element firn densification model for converting volume changes to mass changes

    CERN Document Server

    Cummings, Evan; Brinkerhoff, Douglas

    2013-01-01

    In regions where ice sheets are increasing in mass, there is a 50-200 m layer of old snow called firn which does not melt in the summer months. The density of firn tracks the transformation of snow into glacial ice at approximately 917 kg m^-3. The process of firn densification is important in at least two ways: 1) it can be a dominant component in the observed rate of change of the surface elevation, and 2) storage of liquid water in the lower density firn layer is now considered a critical component in the mass balance of ice sheets. If the rate of change of surface elevation can be equated with the rate of change in the mass of the ice sheet, we would have an excellent means of monitoring ice sheet mass balance. However, knowledge of firn densification rates is needed to make the inference of mass rate of change from volume rate of change. Several firn models have been created for areas without melt. We have reformulated these models with the finite-element software package FEniCS and integrated them with ...

  13. Epidural anesthesia, hypotension, and changes in intravascular volume

    DEFF Research Database (Denmark)

    Holte, Kathrine; Foss, Nicolai B; Svensén, Christer;

    2004-01-01

    BACKGROUND: The most common side effect of epidural or spinal anesthesia is hypotension with functional hypovolemia prompting fluid infusions or administration of vasopressors. Short-term studies (20 min) in patients undergoing lumbar epidural anesthesia suggest that plasma volume may increase wh...

  14. Financing exponential growth at H3

    OpenAIRE

    2012-01-01

    H3 is a fast-food chain that introduced the concept of gourmet hamburgers in the Portuguese market. This case-study illustrates its financing strategy that supported an exponential growth represented by opening 33 restaurants within approximately 3 years of its inception. H3 is now faced with the challenge of structuring its foreign ventures and change its financial approach. The main covered topics are the options an entrepreneur has for financing a new venture and how it evolves along th...

  15. Universality in stochastic exponential growth.

    Science.gov (United States)

    Iyer-Biswas, Srividya; Crooks, Gavin E; Scherer, Norbert F; Dinner, Aaron R

    2014-07-11

    Recent imaging data for single bacterial cells reveal that their mean sizes grow exponentially in time and that their size distributions collapse to a single curve when rescaled by their means. An analogous result holds for the division-time distributions. A model is needed to delineate the minimal requirements for these scaling behaviors. We formulate a microscopic theory of stochastic exponential growth as a Master Equation that accounts for these observations, in contrast to existing quantitative models of stochastic exponential growth (e.g., the Black-Scholes equation or geometric Brownian motion). Our model, the stochastic Hinshelwood cycle (SHC), is an autocatalytic reaction cycle in which each molecular species catalyzes the production of the next. By finding exact analytical solutions to the SHC and the corresponding first passage time problem, we uncover universal signatures of fluctuations in exponential growth and division. The model makes minimal assumptions, and we describe how more complex reaction networks can reduce to such a cycle. We thus expect similar scalings to be discovered in stochastic processes resulting in exponential growth that appear in diverse contexts such as cosmology, finance, technology, and population growth.

  16. Change in heart rate variability following orthostasis relates to volume of exercise in healthy women.

    Science.gov (United States)

    Gilder, Michael; Ramsbottom, Roger

    2008-12-05

    Physically active individuals demonstrate increased heart rate variability (HRV) during rest compared to sedentary individuals, but the impact of different volumes of regular exercise on the HRV response to postural change is not well understood. This study investigates change in HRV following orthostasis in seventy-two young women who exercise at low (LV) or high (HV) volumes of physical activity. Supine and standing R-R intervals were analysed by time domain, frequency domain and Poincaré plot methods. All methods revealed greater change in the vagal response in the HV group, indicating that HRV following postural change is modulated by volume of exercise.

  17. Orthostatic leg blood volume changes assessed by near-infrared spectroscopy

    DEFF Research Database (Denmark)

    Truijen, J; Kim, Y S; Krediet, C T P

    2012-01-01

    posture, volume accumulation in small blood vessels contributes significantly to the total fluid volume accumulated in the legs. Considering that near-infrared spectroscopy (NIRS) tracks postural blood volume changes within the small blood vessels of the lower leg, we evaluated the NIRS-determined changes...... separate days (n = 8). In response to HUT, an initially fast increase in [O(2)Hb] was followed by a gradual decline, while [HHb] increased continuously. The increase in [tHb] during HUT was closely related to the increase in total leg volume (r(2) = 0.95 ± 0.03). After tilt back, [O(2)Hb] declined below...

  18. Epidural anesthesia, hypotension, and changes in intravascular volume

    DEFF Research Database (Denmark)

    Holte, Kathrine; Foss, Nicolai B; Svensén, Christer

    2004-01-01

    hypotension is present, which may have implications for the choice of treatment of hypotension. However, no long-term information or measurements of plasma volumes with or without hypotension after epidural anesthesia are available. METHODS: In 12 healthy volunteers, the authors assessed plasma (125I...... and ephedrine has similar hemodynamic effects, the latter may be preferred in patients with cardiopulmonary diseases in which perioperative fluid overload is undesirable....

  19. Age-related changes in intracranial compartment volumes in normal adults assessed by magnetic resonance imaging.

    Science.gov (United States)

    Matsumae, M; Kikinis, R; Mórocz, I A; Lorenzo, A V; Sándor, T; Albert, M S; Black, P M; Jolesz, F A

    1996-06-01

    Magnetic resonance (MR) image-based computerized segmentation was used to measure various intracranial compartments in 49 normal volunteers ranging in age from 24 to 80 years to determine age-related changes in brain, ventricular, and extraventricular cerebrospinal fluid (CSF) volumes. The total intracranial volume (sum of brain, ventricular, and extraventricular CSF) averaged 1469 +/- 102 cm3 in men and 1289 +/- 111 cm3 in women. The difference was attributable primarily to brain volume, which accounted for 88.6% of the respective intracranial volumes in both sexes, but was significantly larger in men (1302 +/- 112 cm3) than in women (1143 +/- 105 cm3). In both, the cranial CSF volume averaged 11.4%. Total intracranial volume did not change with age, although the normalized brain volume of both men and women began to decrease after the age of 40 years. This decrease was best reflected by expansion of the extraventricular CSF volume which, after the age of 50 years, was more marked in men than in women. The volume of the cranial CSF, as determined by MR image-based computerized segmentation, is considerably larger than traditionally accepted and resides mostly extraventricularly. Expansion of CSF volume with age provides a good index of brain shrinkage although evolving changes and growth of the head with age tend to confound the results.

  20. Human choice and climate change. Volume 2: Resources and technology

    Energy Technology Data Exchange (ETDEWEB)

    Rayner, S.; Malone, E.L.

    1997-12-31

    Foreward: Preface; Introduction; The natural science of global climate change; Land and water use; Coastal zones and oceans; Energy and industry; Energy and social systems; Technological change; and Sponsoring organizations, International Advisory Board, and project participants.

  1. Exponential Expansion in Evolutionary Economics

    DEFF Research Database (Denmark)

    Frederiksen, Peter; Jagtfelt, Tue

    2013-01-01

    concepts are described in detail. Taken together it provides the rudimentary aspects of an economic system within an analytical perspective. It is argued that the main dynamic processes of the evolutionary perspective can be reduced to these four concepts. The model and concepts are evaluated in the light...... of Thomas Kuhn’s notion of scientific paradigms and criteria for a good theory (1977, 1996). The paper thus aims to augment and assimilate the fragmented and scattered body of concepts presently residing within the field of evolutionary economics, by presenting an intuitive framework, applicable within...... to this problem is proposed in the form of a model of exponential expansion. The model outlines the overall structure and function of the economy as exponential expansion. The pictographic model describes four axiomatic concepts and their exponential nature. The interactive, directional, emerging and expanding...

  2. Trait positive affect is associated with hippocampal volume and change in caudate volume across adolescence.

    Science.gov (United States)

    Dennison, Meg; Whittle, Sarah; Yücel, Murat; Byrne, Michelle L; Schwartz, Orli; Simmons, Julian G; Allen, Nicholas B

    2015-03-01

    Trait positive affect (PA) in childhood confers both risk and resilience to psychological and behavioral difficulties in adolescence, although explanations for this association are lacking. Neurodevelopment in key areas associated with positive affect is ongoing throughout adolescence, and is likely to be related to the increased incidence of disorders of positive affect during this period of development. The aim of this study was to prospectively explore the relationship between trait indices of PA and brain development in subcortical reward regions during early to mid-adolescence in a community sample of adolescents. A total of 89 (46 male, 43 female) adolescents participated in magnetic resonance imaging assessments during both early and mid-adolescence (mean age at baseline = 12.6 years, SD = 0.45; mean follow-up period = 3.78 years, SD = 0.21) and also completed self-report measures of trait positive and negative affect (at baseline). To examine the specificity of these effects, the relation between negative affect and brain development was also examined. The degree of volume reduction in the right caudate over time was predicted by PA. Independent of time, larger hippocampal volumes were associated with higher PA, and negative affect was associated with smaller left amygdala volume. The moderating effect of negative affect on the development of the left caudate varied as a function of lifetime psychiatric history. These findings suggest that early to mid-adolescence is an important period whereby neurodevelopmental processes may underlie key phenotypes conferring both risk and resilience for emotional and behavioral difficulties later in life.

  3. Cellular Automaton Simulation For Volume Changes Of Solidifying Nodular Cast Iron

    Directory of Open Access Journals (Sweden)

    Burbelko A.

    2015-09-01

    Full Text Available Volume changes of the binary Fe-C alloy with nodular graphite were forecast by means of the Cellular Automaton Finite Differences (CA-FD model of solidification. Simulations were performed in 2D space for differing carbon content. Dependences of phase density on temperature were considered in the computations; additionally density of the liquid phase and austenite were deemed as a function of carbon concentration. Changes of the specific volume were forecast on the base of the phase volume fractions and changes of phase density. Density of modeled material was calculated as weighted average of densities of each phase.

  4. How do sock ply changes affect residual-limb fluid volume in people with transtibial amputation?

    Directory of Open Access Journals (Sweden)

    Joan E. Sanders, PhD

    2012-04-01

    Full Text Available The purpose of this research was to investigate the influence of sock addition and removal on residual-limb fluid volume in people using prosthetic limbs. We used bioimpedance analysis to measure residual-limb extracellular fluid volume on 28 transtibial amputee subjects during 30 min test sessions. Upon addition of a one-ply polyester sock, residual-limb fluid volume changes ranged from −4.0% to 0.8% (mean −0.9 +/− 1.3% of the initial limb fluid volume. Changes for sock removal ranged from −1.2% to 2.8% (mean 0.5 +/− 0.8%. Subjects who reduced in fluid volume with both addition and removal of a sock and subjects with high positive ratios between the fluid-volume loss upon sock addition and gain upon sock removal (high add/remove [AR] ratios tended to have arterial disease, were obese, and were smokers. Subjects with low positive AR ratios, subjects who increased in fluid volume both with sock addition and removal, and a single subject who increased in fluid volume with sock addition and decreased with sock removal tended to be nonsmokers and either individuals in good health without complications or individuals without arterial problems. Results are relevant for the anticipation of limb volume changes during prosthetic fitting and toward the design of adjustable-socket technologies.

  5. Phenomenology of stochastic exponential growth

    Science.gov (United States)

    Pirjol, Dan; Jafarpour, Farshid; Iyer-Biswas, Srividya

    2017-06-01

    Stochastic exponential growth is observed in a variety of contexts, including molecular autocatalysis, nuclear fission, population growth, inflation of the universe, viral social media posts, and financial markets. Yet literature on modeling the phenomenology of these stochastic dynamics has predominantly focused on one model, geometric Brownian motion (GBM), which can be described as the solution of a Langevin equation with linear drift and linear multiplicative noise. Using recent experimental results on stochastic exponential growth of individual bacterial cell sizes, we motivate the need for a more general class of phenomenological models of stochastic exponential growth, which are consistent with the observation that the mean-rescaled distributions are approximately stationary at long times. We show that this behavior is not consistent with GBM, instead it is consistent with power-law multiplicative noise with positive fractional powers. Therefore, we consider this general class of phenomenological models for stochastic exponential growth, provide analytical solutions, and identify the important dimensionless combination of model parameters, which determines the shape of the mean-rescaled distribution. We also provide a prescription for robustly inferring model parameters from experimentally observed stochastic growth trajectories.

  6. Bilateral matrix-exponential distributions

    DEFF Research Database (Denmark)

    Bladt, Mogens; Esparza, Luz Judith R; Nielsen, Bo Friis

    2012-01-01

    In this article we define the classes of bilateral and multivariate bilateral matrix-exponential distributions. These distributions have support on the entire real space and have rational moment-generating functions. These distributions extend the class of bilateral phasetype distributions of [1]...

  7. Exponential convergence rate in entropy

    Institute of Scientific and Technical Information of China (English)

    Mu-Fa Chen

    2007-01-01

    The exponential convergence rate in entropy is studied for symmetric forms, with a specia! attention to the Markov chain with a state space having two points only. Some upper and lower bounds of the rate are obtained and five examples with precise or qualitatively exact estimates are presented.

  8. Linear or Exponential Number Lines

    Science.gov (United States)

    Stafford, Pat

    2011-01-01

    Having decided to spend some time looking at one's understanding of numbers, the author was inspired by "Alex's Adventures in Numberland," by Alex Bellos to look at one's innate appreciation of number. Bellos quotes research studies suggesting that an individual's natural appreciation of numbers is more likely to be exponential rather than linear,…

  9. Changes in down dead wood volume across a chronosequence of silvicultural openings in southern Indiana forests

    Science.gov (United States)

    Michael A. Jenkins; George R. Parker

    1997-01-01

    The volume and decay stages of down dead wood were evaluated across a chronosequence of 46 silvicultural openings and 10 uncut control stands to determine how down dead wood volume changes with stand development. Openings ranged in age from 8 to 26 years and were divided into three age groups: (1) 16 years. Individual logs...

  10. Study of the seroma volume changes in the patients who underwent Accelerated Partial Breast Irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dae Ho; Son, Sang Jun; Mun, Jun Ki; Seo, Seok Jin; Lee, Je Hee [Dept. of Radiation Oncology, Seoul National University Hospital, Seoul (Korea, Republic of)

    2016-06-15

    By analyzing seroma volume changes in the patients who underwent Partial breast radiation therapy after breast conserving surgery, we try to contribute to the improvement of radiotherapy effect. Enrolled 20 patients who underwent partial breast radiation therapy by ViewRay MRIdian System were subject. After seeking for the size of the removed sample in the patients during surgery and obtained seroma volume changes on a weekly basis. On the Basis of acquired volume, it was compared with age, term from start of the first treatment after surgery, BMI (body mass index) and the extracted sample size during surgery. And using the ViewRay MRIdian RTP System, the figure was analyzed by PTV(=seroma volume + margin) to obtain a specific volume of the Partial breast radiation therapy. The changes of seroma volume from MR simulation to the first treatment (a week) is 0~5% in 8, 5~10% in 3, 10 to 15% in 2, and 20% or more in 5 people. Two patients(A, B patient) among subjects showed the biggest change. The A patient's 100% of the prescribed dose volume is 213.08 cc, PTV is 181.93 cc, seroma volume is 15.3 cc in initial plan. However, while seroma volume decreased 65.36% to 5.3 cc, 100% of the prescribed dose volume was reduced to 3.4% to 102.43 cc and PTV also did 43.6% to 102.54 cc. In the case of the B patient, seroma volume decreased 42.57% from 20.2 cc to 11.6 cc. Because of that, 100% of the prescribed dose volume decreased 8.1% and PTV also did to 40%. As the period between the first therapy and surgery is shorter, the patient is elder and the size of sample is smaller than 100 cc, the change grow bigger. It is desirable to establish an adaptive plan according to each patient's changes of seroma volume through continuous observation. Because partial breast patients is more sensitive than WBRT patients about dose conformity in accordance with the volume change.

  11. SPLENIC VOLUME CHANGE AND THERAPUETIC RESPONSE IN PATIENTS TREATED WITH RADIOMMUNOCONJUGATES

    Energy Technology Data Exchange (ETDEWEB)

    Shen, S; DeNardo, G L; Yuan, A; Siantar, C H; O' Donnell, R T; DeNardo, S J

    2005-04-06

    Splenomegaly is frequently found in non-Hodgkin's lymphoma (NHL) patients. This study evaluated the implications of splenic volume change in response to radioimmunotherapy (RIT). Twenty-nine NHL patients treated with radiolabeled-Lym-1 and 9 breast cancer patients (reference group) treated with radiolabeled-ChL6, BrE-3 or m170 were analyzed using CT splenic images obtained before and after RIT. Patient-specific radiation doses to spleen were determined using actual splenic volume determined by CT and body weight. In 13 of 29 NHL patients who had splenic volume {le} 310 ml, there was no or small change (-23 to 15 mL) in splenic volume, despite splenic doses as high as 14.4 Gy. Similarly, in a reference group of 9 breast cancer patients, there was no or small change (-5 to 13 mL), despite splenic doses as high as 11.4 Gy. In contrast, 13 of 29 NHL patients who had splenic volume 380-1400 mL, splenic volume decreased by 68 to 548 mL despite splenic doses as low as 1.40 Gy. Ten of 29 NHL patients with greater than a 15% decrease in splenic volume after RIT had nodal tumor regression (5 CR, 5 PR). In the remaining 19 NHL patients with less than a 15% decrease in splenic volume after RIT, there were 7 non-responders (5 CR and 7 PR). Splenic volume changes were found in NHL patients with splenomegaly. These splenic volume changes is likely due to therapeutic effect on malignant lymphocytes associated with splenomegaly. Nodal tumor response was more likely when splenomegaly decreased after RIT.

  12. Yield stress, volume change, and shear strength behaviour of unsaturated soils: validation of the SFG model

    National Research Council Canada - National Science Library

    Zhou, Annan; Sheng, Daichao

    2009-01-01

    The model recently presented by Sheng, Fredlund, and Gens, known as the SFG model, provides a consistent explanation of yield stress, shear strength, and volume change behaviour of unsaturated soils...

  13. An Exponentially Small $\\mu$--term in String Theory

    CERN Document Server

    Halyo, Edi

    2009-01-01

    We describe a mechanism that produces an exponentially small $\\mu$--term on the world--volumes of D5 branes wrapping a deformed and fibered $A_3$ singularity. The small $\\mu$ arises due to brane instanton effects which can be calculated after a geometric transition at one of the nodes of the singularity.

  14. Depression may be associated with hippocampal volume changes ...

    African Journals Online (AJOL)

    Adele

    ment score equal to 1.7 Psychosocial functioning is now regarded as a important ... adequate treatment to full remission carries considerable risks not only for the ... It may also lead to or exacerbate structural brain changes in depression, most particu- .... toxicity and decreased levels of BDNF with neuronal atrophy in the.

  15. Limit laws for exponential families

    OpenAIRE

    Balkema, August A.; Klüppelberg, Claudia; Resnick, Sidney I.

    1999-01-01

    For a real random variable [math] with distribution function [math] , define ¶ [math] ¶ The distribution [math] generates a natural exponential family of distribution functions [math] , where ¶ [math] ¶ We study the asymptotic behaviour of the distribution functions [math] as [math] increases to [math] . If [math] then [math] pointwise on [math] . It may still be possible to obtain a non-degenerate weak limit law [math] by choosing suitable scaling and centring constants [math] an...

  16. Limit laws for exponential families

    OpenAIRE

    Balkema, August A.; Klüppelberg, Claudia; Resnick, Sidney I.

    1999-01-01

    For a real random variable [math] with distribution function [math] , define ¶ [math] ¶ The distribution [math] generates a natural exponential family of distribution functions [math] , where ¶ [math] ¶ We study the asymptotic behaviour of the distribution functions [math] as [math] increases to [math] . If [math] then [math] pointwise on [math] . It may still be possible to obtain a non-degenerate weak limit law [math] by choosing suitable scaling and centring constants [math] an...

  17. Age-dependent changes in mitochondrial morphology and volume are not predictors of lifespan.

    Science.gov (United States)

    Regmi, Saroj G; Rolland, Stéphane G; Conradt, Barbara

    2014-02-01

    Mitochondrial dysfunction is a hallmark of skeletal muscle degeneration during aging. One mechanism through which mitochondrial dysfunction can be caused is through changes in mitochondrial morphology. To determine the role of mitochondrial morphology changes in age-dependent mitochondrial dysfunction, we studied mitochondrial morphology in body wall muscles of the nematodeC. elegans. We found that in this tissue, animals display a tubular mitochondrial network, which fragments with increasing age. This fragmentation is accompanied by a decrease in mitochondrial volume. Mitochondrial fragmentation and volume loss occur faster under conditions that shorten lifespan and occur slower under conditions that increase lifespan. However, neither mitochondrial morphology nor mitochondrial volume of five- and seven-day old wild-type animals can be used to predict individual lifespan. Our results indicate that while mitochondria in body wall muscles undergo age-dependent fragmentation and a loss in volume, these changes are not the cause of aging but rather a consequence of the aging process.

  18. Analysis of volumetric response of pituitary adenomas receiving adjuvant CyberKnife stereotactic radiosurgery with the application of an exponential fitting model

    Science.gov (United States)

    Yu, Yi-Lin; Yang, Yun-Ju; Lin, Chin; Hsieh, Chih-Chuan; Li, Chiao-Zhu; Feng, Shao-Wei; Tang, Chi-Tun; Chung, Tzu-Tsao; Ma, Hsin-I; Chen, Yuan-Hao; Ju, Da-Tong; Hueng, Dueng-Yuan

    2017-01-01

    Abstract Tumor control rates of pituitary adenomas (PAs) receiving adjuvant CyberKnife stereotactic radiosurgery (CK SRS) are high. However, there is currently no uniform way to estimate the time course of the disease. The aim of this study was to analyze the volumetric responses of PAs after CK SRS and investigate the application of an exponential decay model in calculating an accurate time course and estimation of the eventual outcome. A retrospective review of 34 patients with PAs who received adjuvant CK SRS between 2006 and 2013 was performed. Tumor volume was calculated using the planimetric method. The percent change in tumor volume and tumor volume rate of change were compared at median 4-, 10-, 20-, and 36-month intervals. Tumor responses were classified as: progression for >15% volume increase, regression for ≤15% decrease, and stabilization for ±15% of the baseline volume at the time of last follow-up. For each patient, the volumetric change versus time was fitted with an exponential model. The overall tumor control rate was 94.1% in the 36-month (range 18–87 months) follow-up period (mean volume change of −43.3%). Volume regression (mean decrease of −50.5%) was demonstrated in 27 (79%) patients, tumor stabilization (mean change of −3.7%) in 5 (15%) patients, and tumor progression (mean increase of 28.1%) in 2 (6%) patients (P = 0.001). Tumors that eventually regressed or stabilized had a temporary volume increase of 1.07% and 41.5% at 4 months after CK SRS, respectively (P = 0.017). The tumor volume estimated using the exponential fitting equation demonstrated high positive correlation with the actual volume calculated by magnetic resonance imaging (MRI) as tested by Pearson correlation coefficient (0.9). Transient progression of PAs post-CK SRS was seen in 62.5% of the patients receiving CK SRS, and it was not predictive of eventual volume regression or progression. A three-point exponential model is of potential predictive value

  19. Red cell volume with changes in plasma osmolarity during maximal exercise.

    Science.gov (United States)

    Van Beaumont, W.

    1973-01-01

    The volume of the red cell in vivo was measured during acute changes in plasma osmolarity evoked through short (6 to 8 min) maximal exercise in six male volunteer subjects. Simultaneous measurements of mean corpuscular red cell volume (MCV), hematocrit, blood hemoglobin, mean corpuscular hemoglobin concentration (MCHC), and plasma osmolarity showed that there was no change in the MCV or MCHC with a concomitant rise of nearly 6% in plasma osmolarity. Apparently, in vivo, the volume of the red cell in exercising healthy human subjects does not change measurably, in spite of significant changes in osmotic pressure of the surrounding medium. Consequently, it is not justified to correct postexercise hematocrit measurements for changes in plasma osmolarity.

  20. Do Acartia tonsa (Dana) eggs regulate their volume and osmolality as salinity changes?

    DEFF Research Database (Denmark)

    Hansen, Benni Winding; Drillet, Guillaume; Pedersen, Morten Foldager;

    2012-01-01

    Subitaneous eggs from an euryhaline calanoid copepod Acartia tonsa were challenged by changes in salinity within the range from full strength salinity, down to zero and up to >70 psu. Egg volume changed immediately, increasing from 2.8 × 105 μm3 at full strength salinity (35 psu) to 3.8 × 105 μm3...... at 0 psu and back to its initial volume when gradually being returned to full strength salinity. Egg osmolality followed the molality of the surrounding water when challenged within a salinity range from 2 to 50 psu. Egg respiration was not affected when eggs kept at 35 psu was exposed to low salinity...... (2 psu). These results suggest that eggs are unable to regulate their volume or osmolality when challenged with changes in salinity. Gradual changes in salinity from 35 to 2 psu and back did not harm the eggs (embryos), since the hatching success remained unaffected by such changes in salinity...

  1. Red cell volume with changes in plasma osmolarity during maximal exercise.

    Science.gov (United States)

    Van Beaumont, W.

    1973-01-01

    The volume of the red cell in vivo was measured during acute changes in plasma osmolarity evoked through short (6 to 8 min) maximal exercise in six male volunteer subjects. Simultaneous measurements of mean corpuscular red cell volume (MCV), hematocrit, blood hemoglobin, mean corpuscular hemoglobin concentration (MCHC), and plasma osmolarity showed that there was no change in the MCV or MCHC with a concomitant rise of nearly 6% in plasma osmolarity. Apparently, in vivo, the volume of the red cell in exercising healthy human subjects does not change measurably, in spite of significant changes in osmotic pressure of the surrounding medium. Consequently, it is not justified to correct postexercise hematocrit measurements for changes in plasma osmolarity.

  2. Thrombus Volume Change Visualization after Endovascular Abdominal Aortic Aneurysm Repair

    Science.gov (United States)

    Maiora, Josu; García, Guillermo; Macía, Iván; Legarreta, Jon Haitz; Boto, Fernando; Paloc, Céline; Graña, Manuel; Abuín, Javier Sanchez

    A surgical technique currently used in the treatment of Abdominal Aortic Aneurysms (AAA) is the Endovascular Aneurysm Repair (EVAR). This minimally invasive procedure involves inserting a prosthesis in the aortic vessel that excludes the aneurysm from the bloodstream. The stent, once in place acts as a false lumen for the blood current to travel down, and not into the surrounding aneurysm sac. This procedure, therefore, immediately takes the pressure off the aneurysm, which thromboses itself after some time. Nevertheless, in a long term perspective, different complications such as prosthesis displacement or bloodstream leaks into or from the aneurysmatic bulge (endoleaks) could appear causing a pressure elevation and, as a result, increasing the danger of rupture. The purpose of this work is to explore the application of image registration techniques to the visual detection of changes in the thrombus in order to assess the evolution of the aneurysm. Prior to registration, both the lumen and the thrombus are segmented

  3. On-line dynamic measurement of blood viscosity, hematocrit and change of blood volume

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Objective: To develop an on-line system for the measurement of blood viscosity and hematocrit. The dynamic changes of the macrovascular blood volumes,microvascular blood volumes and the total blood volume were observed by means of calculating from the testing result. Methods: Applying traditional viscosity measurement principle and specific wavelength optic density measurement method, an on-line system for the measurement of blood viscosity and hematocrit was developed, and the A/D multifunctionai board and the testing circuit were designed by ourselves. The system was validated by experiments both in vitro and in vivo. Therapeutic effects of hypertonic saline dextran solution (HSD) and Lactatic Ringer's solution at the early stage after burn-blast combined injury were compared by this method. Results: The results showed that the system has attained the goal of the design. The changes of the blood viscosity and hematocrit could be detected effectively and continuously. The changes of macrovascular, microvascular and total blood volume could be calculated approximately. Conclusions: The system and the method can continuously on-line test the blood viscosity and hematocrit, and reveal the change and distribution of blood volumes more accurately and dearly in the therapy process by estimating changes of the macrovascular, microvascular and total blood volumes, respectively. It has confirmed that HSD treatment could increase blood pressure and attenuate tissue edema by significantly increasing total blood volume,improving macrocirculatory and microcirculatory blood volumes. This study suggested that it could be desirable to develop an experiment technique based on the method mentioned above.

  4. Evidence for the changes of pituitary volumes in patients with post-traumatic stress disorder.

    Science.gov (United States)

    Atmaca, Murad; Ozer, Omer; Korkmaz, Sevda; Taskent, Ismail; Yildirim, Hanefi

    2017-02-28

    In pubertal and postpubertal patients with post-traumatic stress disorder (PTSD), significantly greater pituitary gland volumes have been reported. Moving from this point, in the present study, we aimed to investigate pituitary gland volumes in patients with PTSD and hypothesized that volumes of the gland would be structurally changed. Volumetric magnetic resonance imaging of the pituitary gland was performed among sixteen patients with PTSD and fifteen healthy control subjects. We found that the mean volume of the pituitary gland was statistically significant and smaller than that of healthy subjects (0.69±0.08cm(3) for patient group and 0.83±0.21 for control subjects). Consequently, in the present study, we found that patients with PTSD had smaller pituitary gland volumes than those of healthy controls like other anxiety disorders. It is important to provide support for this finding in future longitudinal investigations. Copyright © 2016. Published by Elsevier B.V.

  5. Changes in superior mesenteric artery Doppler waveform during reduction of cardiac stroke volume and hypotension

    DEFF Research Database (Denmark)

    Perko, M J; Perko, Grazyna; Just, S

    1996-01-01

    Influence of stroke volume reduction and hypotension on the superior mesenteric artery (SMA) Doppler waveform was evaluated during head-up tilt-induced central hypovolemia in 11 healthy volunteers. During normotensive reduction in stroke volume, peak systolic velocity (pV), mean velocity, pulsati......Influence of stroke volume reduction and hypotension on the superior mesenteric artery (SMA) Doppler waveform was evaluated during head-up tilt-induced central hypovolemia in 11 healthy volunteers. During normotensive reduction in stroke volume, peak systolic velocity (pV), mean velocity...... of the study indicate that alterations in stroke volume induce consequential changes in the SMA Doppler waveform. These changes originate from both direct influence of stroke volume and/or pressure on blood flow velocity, and alterations in SMA peripheral resistance that follow variations in stroke volume....... Presented interdependencies should be taken into consideration while studying mesenteric physiology with the use of Doppler technique and while interpreting the duplex results in patients suffering from diseases that may influence flow velocity and mimic or obscure Doppler effects of the SMA stenosis....

  6. Longitudinal changes in hippocampal volumes and cognition in remitted geriatric depressive disorder.

    Science.gov (United States)

    Hou, Zhenghua; Yuan, Yonggui; Zhang, Zhijun; Bai, Feng; Hou, Gang; You, Jiayong

    2012-02-01

    Growing evidences suggest that the abnormality of hippocampal volume may occur in the process of depression. In this longitudinal study, we calculated the hippocampal volume of 14 remitted geriatric depressed (RGD) patients and 19 healthy participants at baseline and follow-up. We found significant improvement of performance in Trail Making Test-A (P=0.038) and Test-B (P=0.032), and the right hippocampal volume increased mildly in RGD. However, in RGD patients, positive correlations were seen between the changes in right hippocampal volumes and Symbol Digit Modality Test scores (r=0.675, P=0.008), and changes in left hippocampal volumes and Mini-Mental State Examination scores (r=0.743, P=0.002). Our findings suggest that hippocampus related cognitive impairment and previously addressed decreased hippocampal volume might represent a state rather than a permanent trait of the depressive disorder. The results suggest that hippocampal volume may be a useful risk marker for conversion to Alzheimer's disease in RGD patients. Additionally, our study indicates that effective antidepressants treatment might postpone and even revise the deterioration of hippocampus to some degree. Copyright © 2011 Elsevier B.V. All rights reserved.

  7. Modulation of KCNQ4 channel activity by changes in cell volume

    DEFF Research Database (Denmark)

    Hougaard, Charlotte; Klaerke, Dan A; Hoffmann, Else K;

    2004-01-01

    KCNQ4 channels expressed in HEK 293 cells are sensitive to cell volume changes, being activated by swelling and inhibited by shrinkage, respectively. The KCNQ4 channels contribute significantly to the regulatory volume decrease (RVD) process following cell swelling. Under isoosmotic conditions......, the KCNQ4 channel activity is modulated by protein kinases A and C, G protein activation, and a reduction in the intracellular Ca2+ concentration, but these signalling pathways are not responsible for the increased channel activity during cell swelling....

  8. Cosmological evolution in exponential gravity

    Energy Technology Data Exchange (ETDEWEB)

    Bamba, Kazuharu; Geng, Chao-Qiang; Lee, Chung-Chi, E-mail: bamba@phys.nthu.edu.tw, E-mail: geng@phys.nthu.edu.tw, E-mail: g9522545@oz.nthu.edu.tw [Department of Physics, National Tsing Hua University, Hsinchu, Taiwan (China)

    2010-08-01

    We explore the cosmological evolution in the exponential gravity f(R) = R+c{sub 1}(1−e{sup −c{sub 2}R}) (c{sub 1,2} = constant). We summarize various viability conditions and explicitly demonstrate that the late-time cosmic acceleration following the matter-dominated stage can be realized. We also study the equation of state for dark energy and confirm that the crossing of the phantom divide from the phantom phase to the non-phantom (quintessence) one can occur. Furthermore, we illustrate that the cosmological horizon entropy globally increases with time.

  9. Cosmological evolution in exponential gravity

    CERN Document Server

    Bamba, Kazuharu; Lee, Chung-Chi

    2010-01-01

    We explore the cosmological evolution in the exponential gravity $f(R)=R +c_1 \\left(1-e^{- c_2 R} \\right)$ ($c_{1, 2} = \\mathrm{constant}$). We summarize various viability conditions and explicitly demonstrate that the late-time cosmic acceleration following the matter-dominated stage can be realized. We also study the equation of state for dark energy and confirm that the crossing of the phantom divide from the phantom phase to the non-phantom (quintessence) one can occur. Furthermore, we illustrate that the cosmological horizon entropy globally increases with time.

  10. Temporal dynamics and determinants of whole brain tissue volume changes during recovery from alcohol dependence.

    Science.gov (United States)

    Gazdzinski, Stefan; Durazzo, Timothy C; Meyerhoff, Dieter J

    2005-06-01

    Brain shrinkage and its partial reversibility with abstinence is a common neuroimaging finding in alcohol dependent individuals. We used an automated three-dimensional whole brain magnetic resonance imaging method (boundary shift integral) in 23 alcohol dependent individuals to measure the temporal dynamics of cerebral tissue and spinal fluid volume changes over a 12-month interval and to examine the major determinants of brain tissue change rates during abstinence and non-abstinence. We found more rapid brain tissue gain during the first month of sobriety than in the following months. The most rapid volume recovery was observed in abstinent individuals with the greatest baseline brain shrinkage and drinking severity. The rapid reversal of brain volume gains in non-abstinent individuals and tissue volume changes are modulated by duration of abstinence and non-abstinence periods, as well as recency of non-abstinence. Age, family history density of alcoholism, relapse severity, and duration or age of onset of heavy drinking were not major determinants of brain shrinkage and brain volume recovery rates. Treatment providers may use this tangible information to reinforce the biomedical benefits of sobriety. Previous quantitative measurements of brain volumes in alcohol dependent individuals performed after several weeks of abstinence likely underestimated the full extent of chronic alcohol-associated brain shrinkage.

  11. On uniform exponential growth for solvable groups

    OpenAIRE

    Breuillard, Emmanuel

    2006-01-01

    Using a theorem of J. Groves we give a ping-pong proof of Osin's uniform exponential growth for solvable groups. We discuss slow exponential growth and show that this phenomenon disappears as one passes to a finite index subgroup.

  12. Teaching about Exponential Growth in Social Studies.

    Science.gov (United States)

    Allen, Rodney F.; LaHart, David E.

    1984-01-01

    Characteristics of exponential growth which should be taught in social studies classes are listed, and learning activities dealing with exponential growth which can be used in secondary social studies classes are provided. (RM)

  13. Airborne laser quantification of Florida shoreline and beach volume change caused by hurricanes

    Science.gov (United States)

    Robertson, William, V.

    This dissertation combines three separate studies that measure coastal change using airborne laser data. The initial study develops a method for measuring subaerial and subaqueous volume change incrementally alongshore, and compares those measurements to shoreline change in order to quantify their relationship in Palm Beach County, Florida. A poor correlation (R2 = 0.39) was found between shoreline and volume change before the hurricane season in the northern section of Palm Beach County because of beach nourishment and inlet dynamics. However, a relatively high R2 value of 0.78 in the southern section of Palm Beach County was found due to little disturbance from tidal inlets and coastal engineering projects. The shoreline and volume change caused by the 2004 hurricane season was poorly correlated with R 2 values of 0.02 and 0.42 for the north and south sections, respectively. The second study uses airborne laser data to investigate if there is a significant relationship between shoreline migration before and after Hurricane Ivan near Panama City, Florida. In addition, the relationship between shoreline change and subaerial volume was quantified and a new method for quantifying subaqueous sediment change was developed. No significant spatial relationship was found between shoreline migration before and after the hurricane. Utilization of a single coefficient to represent all relationships between shoreline and subaerial volume change was found to be problematic due to the spatial variability in the linear relationship. Differences in bathymetric data show only a small portion of sediment was transported beyond the active zone and most sediment remained within the active zone despite the occurrence of a hurricane. The third study uses airborne laser bathymetry to measure the offshore limit of change, and compares that location with calculated depth of closures and subaqueous geomorphology. There appears to be strong geologic control of the depth of closure in

  14. Thermal Volume Change of Unsaturated Silt under Different Stress States and Suction Magnitudes

    Directory of Open Access Journals (Sweden)

    McCartney John S.

    2016-01-01

    Full Text Available This paper presents an evaluation of the thermal volume change of compacted specimens of the same type of silt under a wide range of stress states, initial void ratios, and suction magnitudes. Stress states include both isotropic and anisotropic conditions with varying principal stress ratios, as well as normally consolidated and overconsolidated conditions. Initial void ratios range from 0.60 to 0.86, spanning very dense to loose conditions. Suctions evaluated range from saturated conditions, to low suctions in the funicular range, to suctions corresponding to residual saturation conditions. For the same soil, wide variations in thermal volume change are observed. Thermal contraction is observed for normally consolidated conditions regardless of the initial degree of saturation. Different mechanisms of thermal volume change can be used to explain the results, ranging from thermally-induced pore water pressure dissipation, to thermal collapse, to thermally-accelerated creep.

  15. Notes on the Stochastic Exponential and Logarithm

    OpenAIRE

    Larsson, Martin; Ruf, Johannes

    2017-01-01

    Stochastic exponentials are defined for semimartingales on stochastic intervals, and stochastic logarithms are defined for nonnegative semimartingales, up to the first time the semimartingale hits zero continuously. In the case of (nonnegative) local supermartingales, these two stochastic transformations are inverse to each other. The reciprocal of a stochastic exponential is again a stochastic exponential on a stochastic interval.

  16. Brain putamen volume changes in newly-diagnosed patients with obstructive sleep apnea.

    Science.gov (United States)

    Kumar, Rajesh; Farahvar, Salar; Ogren, Jennifer A; Macey, Paul M; Thompson, Paul M; Woo, Mary A; Yan-Go, Frisca L; Harper, Ronald M

    2014-01-01

    Obstructive sleep apnea (OSA) is accompanied by cognitive, motor, autonomic, learning, and affective abnormalities. The putamen serves several of these functions, especially motor and autonomic behaviors, but whether global and specific sub-regions of that structure are damaged is unclear. We assessed global and regional putamen volumes in 43 recently-diagnosed, treatment-naïve OSA (age, 46.4 ± 8.8 years; 31 male) and 61 control subjects (47.6 ± 8.8 years; 39 male) using high-resolution T1-weighted images collected with a 3.0-Tesla MRI scanner. Global putamen volumes were calculated, and group differences evaluated with independent samples t-tests, as well as with analysis of covariance (covariates; age, gender, and total intracranial volume). Regional differences between groups were visualized with 3D surface morphometry-based group ratio maps. OSA subjects showed significantly higher global putamen volumes, relative to controls. Regional analyses showed putamen areas with increased and decreased tissue volumes in OSA relative to control subjects, including increases in caudal, mid-dorsal, mid-ventral portions, and ventral regions, while areas with decreased volumes appeared in rostral, mid-dorsal, medial-caudal, and mid-ventral sites. Global putamen volumes were significantly higher in the OSA subjects, but local sites showed both higher and lower volumes. The appearance of localized volume alterations points to differential hypoxic or perfusion action on glia and other tissues within the structure, and may reflect a stage in progression of injury in these newly-diagnosed patients toward the overall volume loss found in patients with chronic OSA. The regional changes may underlie some of the specific deficits in motor, autonomic, and neuropsychologic functions in OSA.

  17. Brain putamen volume changes in newly-diagnosed patients with obstructive sleep apnea

    Directory of Open Access Journals (Sweden)

    Rajesh Kumar

    2014-01-01

    Full Text Available Obstructive sleep apnea (OSA is accompanied by cognitive, motor, autonomic, learning, and affective abnormalities. The putamen serves several of these functions, especially motor and autonomic behaviors, but whether global and specific sub-regions of that structure are damaged is unclear. We assessed global and regional putamen volumes in 43 recently-diagnosed, treatment-naïve OSA (age, 46.4 ± 8.8 years; 31 male and 61 control subjects (47.6 ± 8.8 years; 39 male using high-resolution T1-weighted images collected with a 3.0-Tesla MRI scanner. Global putamen volumes were calculated, and group differences evaluated with independent samples t-tests, as well as with analysis of covariance (covariates; age, gender, and total intracranial volume. Regional differences between groups were visualized with 3D surface morphometry-based group ratio maps. OSA subjects showed significantly higher global putamen volumes, relative to controls. Regional analyses showed putamen areas with increased and decreased tissue volumes in OSA relative to control subjects, including increases in caudal, mid-dorsal, mid-ventral portions, and ventral regions, while areas with decreased volumes appeared in rostral, mid-dorsal, medial-caudal, and mid-ventral sites. Global putamen volumes were significantly higher in the OSA subjects, but local sites showed both higher and lower volumes. The appearance of localized volume alterations points to differential hypoxic or perfusion action on glia and other tissues within the structure, and may reflect a stage in progression of injury in these newly-diagnosed patients toward the overall volume loss found in patients with chronic OSA. The regional changes may underlie some of the specific deficits in motor, autonomic, and neuropsychologic functions in OSA.

  18. Electrolyte and Haemogram changes post large volume liposuction comparing two different tumescent solutions

    Directory of Open Access Journals (Sweden)

    Kumar Vivek

    2014-01-01

    Full Text Available Background: The most common definitions of large volume liposuction refer to total 5 l volume aspiration during a single procedure (fat plus wetting solution. Profound haemodynamic and metabolic alterations can accompany large volume liposuction. Due to paucity of literature on the effect of different tumescent solutions on the electrolyte balance and haematological changes during large volume liposuction, we carried out this study using two different wetting solutions to study the same. Materials and Methods: Total 30 patients presenting with varying degrees of localized lipodystrophy in different body regions were enrolled for the study. Prospective randomized controlled trial was conducted by Department of Plastic and Cosmetic Surgery, Sir Ganga Ram Hospital, New Delhi from January 2011 to June 2012. Patients were randomized into two groups of 15 patients each by using computer generated random numbers. Tumescent formula used for Group A (normal saline [NS] was our modification of Klein′s Formula and Tumescent formula used for Group B (ringer lactate [RL] was our modification of Hunstadt′s formula. Serum electrolytes and hematocrit levels were done at preinduction, immediate postoperative period and postoperative day 1. Result: Statistical analysis was performed using SPSS software version 15.0. Which showed statistically significant electrolytes and hematocrit changes occur during large volume liposuction. Conclusion: Statistically significant electrolytes and hematocrit changes occur during large volume liposuction and patients should be kept under observation of anaesthesist for at least 24 h. Patients require strict monitoring of vital parameters and usually Intensive Care Unit is not required. There was no statistical difference in the electrolyte changes using NS or RL as tumescent solution and both solutions were found safe for large volume liposuction.

  19. Expiratory computed tomographic techniques: a cause of a poor rate of change in lung volume.

    Science.gov (United States)

    Morikawa, Keiko; Okada, Fumito; Mori, Hiromu

    2015-01-01

    Ninety-nine patients (29 males and 70 females; mean age, 57.1 years; range, 22-81 years) were included in this study to evaluate the factors affecting smaller lung volume changes in expiratory high-resolution computed tomography performed to depict air trapping. All patients underwent inspiratory and expiratory chest thin-section CT examinations and pulmonary function tests. Air trapping on CT images was graded subjectively. All variables (age, sex, diagnosis, pulmonary function index, and air trapping score) were compared with the degree of change in lung volume between the inspiratory and expiratory CT examinations. The variables affecting a lower degree of volume change were vital capacity, forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1.0), and the FEV1.0/FVC ratio. Bronchiolitis obliterans was the dominant diagnosis in patients with insufficient degrees of breath holding and in patients with negative air trapping scores despite an abnormal air trapping index. An insufficient degree of lung changes between inspiration and expiration on CT examinations represented bronchiolitis obliterans, which resulted in low FEV1.0 and FEV1.0/FVC values. Changes in the time gap from the announcement of exhalation and breath holding to the start of scanning most effectively indicated air trapping in patients with bronchiolar disorders.

  20. EFFECT OF SITTING POSTURE ON THORACIC CONFIGURATION AND CHANGES IN VOLUME OF HEMITHORACES

    Directory of Open Access Journals (Sweden)

    Shōbo A

    2017-06-01

    Full Text Available Background: Poor posture is detrimental to breathing. Our purpose was to investigate the effect of upright and hunchbacked sitting on thoracic configuration and changes in the volume of the thorax during quiet and volitional deep breathing. Methods: The participants were 11 healthy men with a mean age of 21.6 years, mean body mass of 59.8 kg, mean height of 169.7 cm and a body mass index of 20.7 kg/m2. Eighty-four reflective markers were placed on the trunk. Three-dimensional motion analysis measured the volume within the hemithoraces. To calculate upper and lower thoracic volumes, six imaginary hexahedra were visualized using four reflective markers for each on both aspects of the thorax. Each hexahedron was divided into three imaginary triangular pyramids to calculate positional vectors. Finally, the volume for the hexahedra and triangular pyramids was calculated. Upper thoracic volume encompassed a space from the sternal notch to a midpoint on the ventral aspect of the third rib and the lower thoracic volume from the xiphoid process to the midpoint on tenth rib’s dorsal aspect. Results: In hunchbacked sitting during quiet breathing the left lower hemithorax yielded a significantly larger volume (p=0.003, and both breathing patterns during inspiration and expiration yielded a significantly greater change in thoracic configuration (p=0.01, p=0.016. Conclusion: Findings suggested that, in a hunchbacked sitting, there was decreased thoracic asymmetry with re-establishment of thoracic vertebral alignment, consequently stabilizing the sitting position, but breathing was suppressed and tidal volume decreased. Physiotherapy should aim at ensuring correction of hunchbacked posture and maintenance of thoracic symmetry.

  1. MECO In An Exponential Metric

    CERN Document Server

    Robertson, Stanley L

    2016-01-01

    Magnetic Eternally Collapsing Objects (MECO) have been proposed as the central engines of galactic black hole candidates (GBHC) and supermassive active galactic nuclei (AGN). Previous work has shown that their luminosities and spectral and timing characteristics are in good agreement with observations. These features and the formation of jets are generated primarily by the interactions of accretion disks with an intrinsically magnetic central MECO. The interaction of accretion disks with the anchored magnetic fields of the central objects permits a unified description of properties for GBHC, AGN, neutron stars in low mass x-ray binaries and dwarf novae systems. The previously published MECO models have been based on a quasistatic Schwarzschild metric of General Relativity; however, the only essential feature of this metric is its ability to produce extreme gravitational redshifts. For reasons discussed in this article, an alternative development based on a quasistatic exponential metric is considered here.

  2. Observational Constraints on Exponential Gravity

    CERN Document Server

    Yang, Louis; Luo, Ling-Wei; Geng, Chao-Qiang

    2010-01-01

    We study the observational constraints on the exponential gravity model of f(R)=-beta*Rs(1-e^(-R/Rs)). We use the latest observational data including Supernova Cosmology Project (SCP) Union2 compilation, Two-Degree Field Galaxy Redshift Survey (2dFGRS), Sloan Digital Sky Survey Data Release 7 (SDSS DR7) and Seven-Year Wilkinson Microwave Anisotropy Probe (WMAP7) in our analysis. From these observations, we obtain a lower bound on the model parameter beta at 1.27 (95% CL) but no appreciable upper bound. The constraint on the present matter density parameter is 0.245< Omega_m^0<0.311 (95% CL). We also find out the best-fit value of model parameters on several cases.

  3. UCB Algorithm for Exponential Distributions

    CERN Document Server

    Jouini, Wassim

    2012-01-01

    We introduce in this paper a new algorithm for Multi-Armed Bandit (MAB) problems. A machine learning paradigm popular within Cognitive Network related topics (e.g., Spectrum Sensing and Allocation). We focus on the case where the rewards are exponentially distributed, which is common when dealing with Rayleigh fading channels. This strategy, named Multiplicative Upper Confidence Bound (MUCB), associates a utility index to every available arm, and then selects the arm with the highest index. For every arm, the associated index is equal to the product of a multiplicative factor by the sample mean of the rewards collected by this arm. We show that the MUCB policy has a low complexity and is order optimal.

  4. PARAMETER ESTIMATION OF EXPONENTIAL DISTRIBUTION

    Institute of Scientific and Technical Information of China (English)

    XU Haiyan; FEI Heliang

    2005-01-01

    Because of the importance of grouped data, many scholars have been devoted to the study of this kind of data. But, few documents have been concerned with the threshold parameter. In this paper, we assume that the threshold parameter is smaller than the first observing point. Then, on the basis of the two-parameter exponential distribution, the maximum likelihood estimations of both parameters are given, the sufficient and necessary conditions for their existence and uniqueness are argued, and the asymptotic properties of the estimations are also presented, according to which approximate confidence intervals of the parameters are derived. At the same time, the estimation of the parameters is generalized, and some methods are introduced to get explicit expressions of these generalized estimations. Also, a special case where the first failure time of the units is observed is considered.

  5. Dynamic cortical gray matter volume changes after botulinum toxin in cervical dystonia

    NARCIS (Netherlands)

    Delnooz, C.C.S.; Pasman, J.W.; Warrenburg, B.P.C. van de

    2015-01-01

    Previous electrophysiological and functional imaging studies in focal dystonia have reported on cerebral reorganization after botulinum toxin (BoNT) injections. With the exception of microstructural changes, alterations in gray matter volume after BoNT have not been explored. In this study, we

  6. Surprising volume change in PPy(DBS): An atomic force microscopy study

    DEFF Research Database (Denmark)

    Smela, E.; Gadegaard, N.

    1999-01-01

    Communication: Conjugated polymers such as polypyrrole (PPy) have potential use as artificial muscles or in microsystems such as valves for micro-fluid handling. One of the most important parameters in such uses is the magnitude of volume change during associated redox processes; however, until now...

  7. Changes in forced expiratory volume in 1 second over time in COPD

    DEFF Research Database (Denmark)

    Vestbo, Jørgen; Edwards, Lisa D; Scanlon, Paul D

    2011-01-01

    A key feature of chronic obstructive pulmonary disease (COPD) is an accelerated rate of decline in forced expiratory volume in 1 second (FEV(1)), but data on the variability and determinants of this change in patients who have established disease are scarce....

  8. Challenges in Accommodating Volume Change of Si Anodes for Li-Ion Batteries.

    Science.gov (United States)

    Ko, Minseong; Chae, Sujong; Cho, Jaephil

    2015-11-01

    Si has been considered as a promising alternative anode for next-generation Li-ion batteries (LIBs) because of its high theoretical energy density, relatively low working potential, and abundance in nature. However, Si anodes exhibit rapid capacity decay and an increase in the internal resistance, which are caused by the large volume changes upon Li insertion and extraction. This unfortunately limits their practical applications. Therefore, managing the total volume change remains a critical challenge for effectively alleviating the mechanical fractures and instability of solid-electrolyte-interphase products. In this regard, we review the recent progress in volume-change-accommodating Si electrodes and investigate their ingenious structures with significant improvements in the battery performance, including size-controlled materials, patterned thin films, porous structures, shape-preserving shell designs, and graphene composites. These representative approaches potentially overcome the large morphologic changes in the volume of Si anodes by securing the strain relaxation and structural integrity in the entire electrode. Finally, we propose perspectives and future challenges to realize the practical application of Si anodes in LIB systems.

  9. Changes in forced expiratory volume in 1 second over time in COPD

    DEFF Research Database (Denmark)

    Vestbo, Jørgen; Edwards, Lisa D; Scanlon, Paul D

    2011-01-01

    A key feature of chronic obstructive pulmonary disease (COPD) is an accelerated rate of decline in forced expiratory volume in 1 second (FEV(1)), but data on the variability and determinants of this change in patients who have established disease are scarce....

  10. Age-related changes in body fluid volumes in young spontaneously hypertensive rats

    Energy Technology Data Exchange (ETDEWEB)

    Von Dreele, M.M. (Wright State Univ., Dayton, OH (USA))

    1988-11-01

    The authors have measured total body water (TBW, by dessiccation), extracellular fluid volume (ECF, Na{sub 2}{sup 35}SO{sub 4} space), and plasma volume (PV, radioiodinated serum albumin space) in 5-sec-butyl-5-ethyl-2-thiobarbituric acid and sodium salt (Inactin)-anesthetized spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats aged 12-60 days. Interstitial fluid volume (ISF) was calculated as ECF minus PV. Changes in TBW, ECF, and ISF were largely a function of age in both strains, which is typical of developing mammals. Further analysis revealed that although these volumes were significantly larger in SHR before 25 days of age, after 30 days no difference existed between the strains. Before 25 days of age, when SHR's TBW was expanded, no weight difference was seen between the strains. However, once TBW was normalized (after 30 days), WKY was significantly heavier than SHR. The ISF volume was preferentially enlarged in SHR, although PV was also periodically greater. ISF normalized at the time when blood pressure becomes significantly higher in SHR, when plasma aldosterone falls to WKY values in SHR and when renal function is approaching adult levels. Thus the return of ECF (ISF) to normal values may be a result of decreased aldosterone-dependent volume retention or to diuresis induced by increasing blood pressure in an animal whose renal function is close to maturity.

  11. Changes in extracellular muscle volume affect heart rate and blood pressure responses to static exercise

    Science.gov (United States)

    Baum, K.; Essfeld, D.; Stegemann, J.

    To investigate the effect of μg-induced peripheral extracellular fluid reductions on heart rate and blood pressure during isometric exercise, six healthy male subjects performed three calf ergometer test with different extracellular volumes of working muscles. In all tests, body positions during exercise were identical (supine with the knee joint flexed to 900). After a pre-exercise period of 25 min, during which calf volumes were manipulated, subjects had to counteract an external force of 180 N for 5 min. During the pre-exercise period three different protocols were applied. Test A: Subjects rested in the exercise position; test B: Body position was the same as in A but calf volume was increased by venous congestion (cuffs inflated to 80 mm Hg); test C: Calf volumes were decreased by a negative hydrostatic pressure (calves about 40 cm above heart level with the subjects supine). To clamp the changed calf volumes in tests B and C, cuffs were inflated to 300 mm Hg 5 min before the onset of exercise. This occlusion was maintained until termination of exercise. Compared to tests A and B, the reduced volume of test C led to significant increases in heart rate and blood pressure during exercise. Oxygen uptake did not exceed resting levels in B and C until cuffs were deflated, indicating that exclusively calf muscles contributed to the neurogenic peripheral drive. It is concluded that changes in extracellular muscle volume have to be taken into account when comparing heart rate and blood pressure during lg- and μg- exercise.

  12. Mechanism of Calcined Phosphogypsum for the Volume Change of Blended Cement

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The paper describes an investigation into the volume change of cement mortar specimen at the three kinds of different curing schedules including 20℃ and 5% Na2SO4 solution curing, tap water standard curing, 50% RH curing for 90 days. The testing results of hydration heat, chemical shrinking and XRD prove that calcined phosphogypsum has evident excitation effect on the activity of high calcium ash and steel slag. Simultaneously, calcined phosphogypsum has the function of decreasing volume shrinkage to blended cement possessing steel slag and high calcium ash. In sulfate curing, calcined phosphogypsum can avoid the phenomenon of protrude apex of the blended cement.

  13. A lattice Boltzmann coupled to finite volumes method for solving phase change problems

    Directory of Open Access Journals (Sweden)

    El Ganaoui Mohammed

    2009-01-01

    Full Text Available A numerical scheme coupling lattice Boltzmann and finite volumes approaches has been developed and qualified for test cases of phase change problems. In this work, the coupled partial differential equations of momentum conservation equations are solved with a non uniform lattice Boltzmann method. The energy equation is discretized by using a finite volume method. Simulations show the ability of this developed hybrid method to model the effects of convection, and to predict transfers. Benchmarking is operated both for conductive and convective situation dominating solid/liquid transition. Comparisons are achieved with respect to available analytical solutions and experimental results.

  14. Vortex structures in exponentially shaped Josephson junctions

    Science.gov (United States)

    Shukrinov, Yu. M.; Semerdjieva, E. G.; Boyadjiev, T. L.

    2005-04-01

    We report the numerical calculations of the static vortex structure and critical curves in exponentially shaped long Josephson junctions for in-line and overlap geometries. Stability of the static solutions is investigated by checking the sign of the smallest eigenvalue of the associated Sturm-Liouville problem. The change in the junction width leads to the renormalization of the magnetic flux in comparison with the case of a linear one-dimensional model. We study the influence of the model's parameters, and particularly, the shape parameter on the stability of the states of the magnetic flux. We compare the vortex structure and critical curves for the in-line and overlap geometries. Our numerically constructed critical curve of the Josephson junction matches well with the experimental one.

  15. Changes in subcutaneous fat cell volume and insulin sensitivity after weight loss.

    Science.gov (United States)

    Andersson, Daniel P; Eriksson Hogling, Daniel; Thorell, Anders; Toft, Eva; Qvisth, Veronica; Näslund, Erik; Thörne, Anders; Wirén, Mikael; Löfgren, Patrik; Hoffstedt, Johan; Dahlman, Ingrid; Mejhert, Niklas; Rydén, Mikael; Arner, Erik; Arner, Peter

    2014-07-01

    Large subcutaneous fat cells associate with insulin resistance and high risk of developing type 2 diabetes. We investigated if changes in fat cell volume and fat mass correlate with improvements in the metabolic risk profile after bariatric surgery in obese patients. Fat cell volume and number were measured in abdominal subcutaneous adipose tissue in 62 obese women before and 2 years after Roux-en-Y gastric bypass (RYGB). Regional body fat mass by dual-energy X-ray absorptiometry; insulin sensitivity by hyperinsulinemic-euglycemic clamp; and plasma glucose, insulin, and lipid profile were assessed. RYGB decreased body weight by 33%, which was accompanied by decreased adipocyte volume but not number. Fat mass in the measured regions decreased and all metabolic parameters were improved after RYGB (P fat cell size correlated strongly with improved insulin sensitivity (P = 0.0057), regional changes in fat mass did not, except for a weak correlation between changes in visceral fat mass and insulin sensitivity and triglycerides. The curve-linear relationship between fat cell size and fat mass was altered after weight loss (P = 0.03). After bariatric surgery in obese women, a reduction in subcutaneous fat cell volume associates more strongly with improvement of insulin sensitivity than fat mass reduction per se. An altered relationship between adipocyte size and fat mass may be important for improving insulin sensitivity after weight loss. Fat cell size reduction could constitute a target to improve insulin sensitivity. © 2014 by the American Diabetes Association.

  16. Exponential Stabilization of Underactuated Vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Pettersen, K.Y.

    1996-12-31

    Underactuated vehicles are vehicles with fewer independent control actuators than degrees of freedom to be controlled. Such vehicles may be used in inspection of sub-sea cables, inspection and maintenance of offshore oil drilling platforms, and similar. This doctoral thesis discusses feedback stabilization of underactuated vehicles. The main objective has been to further develop methods from stabilization of nonholonomic systems to arrive at methods that are applicable to underactuated vehicles. A nonlinear model including both dynamics and kinematics is used to describe the vehicles, which may be surface vessels, spacecraft or autonomous underwater vehicles (AUVs). It is shown that for a certain class of underactuated vehicles the stabilization problem is not solvable by linear control theory. A new stability result for a class of homogeneous time-varying systems is derived and shown to be an important tool for developing continuous periodic time-varying feedback laws that stabilize underactuated vehicles without involving cancellation of dynamics. For position and orientation control of a surface vessel without side thruster a new continuous periodic feedback law is proposed that does not cancel any dynamics, and that exponentially stabilizes the origin of the underactuated surface vessel. A further issue considered is the stabilization of the attitude of an AUV. Finally, the thesis discusses stabilization of both position and attitude of an underactuated AUV. 55 refs., 28 figs.

  17. Theory, computation, and application of exponential splines

    Science.gov (United States)

    Mccartin, B. J.

    1981-01-01

    A generalization of the semiclassical cubic spline known in the literature as the exponential spline is discussed. In actuality, the exponential spline represents a continuum of interpolants ranging from the cubic spline to the linear spline. A particular member of this family is uniquely specified by the choice of certain tension parameters. The theoretical underpinnings of the exponential spline are outlined. This development roughly parallels the existing theory for cubic splines. The primary extension lies in the ability of the exponential spline to preserve convexity and monotonicity present in the data. Next, the numerical computation of the exponential spline is discussed. A variety of numerical devices are employed to produce a stable and robust algorithm. An algorithm for the selection of tension parameters that will produce a shape preserving approximant is developed. A sequence of selected curve-fitting examples are presented which clearly demonstrate the advantages of exponential splines over cubic splines.

  18. Volume change determination of metastatic lung tumors in CT images using 3-D template matching

    Science.gov (United States)

    Ambrosini, Robert D.; Wang, Peng; O'Dell, Walter G.

    2009-02-01

    The ability of a clinician to properly detect changes in the size of lung nodules over time is a vital element to both the diagnosis of malignant growths and the monitoring of the response of cancerous lesions to therapy. We have developed a novel metastasis sizing algorithm based on 3-D template matching with spherical tumor appearance models that were created to match the expected geometry of the tumors of interest while accounting for potential spatial offsets of nodules in the slice thickness direction. The spherical template that best-fits the overall volume of each lung metastasis was determined through the optimization of the 3-D normalized cross-correlation coefficients (NCCC) calculated between the templates and the nodules. A total of 17 different lung metastases were extracted manually from real patient CT datasets and reconstructed in 3-D using spherical harmonics equations to generate simulated nodules for testing our algorithm. Each metastasis 3-D shape was then subjected to 10%, 25%, 50%, 75% and 90% scaling of its volume to allow for 5 possible volume change combinations relative to the original size per each reconstructed nodule and inserted back into CT datasets with appropriate blurring and noise addition. When plotted against the true volume change, the nodule volume changes calculated by our algorithm for these 85 data points exhibited a high degree of accuracy (slope = 0.9817, R2 = 0.9957). Our results demonstrate that the 3-D template matching method can be an effective, fast, and accurate tool for automated sizing of metastatic tumors.

  19. 3D mapping of cerebrospinal fluid local volume changes in patients with hydrocephalus treated by surgery: preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Hodel, Jerome [Hopital Roger Salengro, Department of Neuroradiology, Lille (France); Hopital Roger Salengro, Service de Neuroradiologie, Lille (France); Besson, Pierre; Pruvo, Jean-Pierre; Leclerc, Xavier [Hopital Roger Salengro, Department of Neuroradiology, Lille (France); Rahmouni, Alain; Grandjacques, Benedicte; Luciani, Alain [Hopital Henri Mondor, Department of Radiology, Creteil (France); Petit, Eric; Lebret, Alain [Signals Images and Intelligent Systems Laboratory, Creteil (France); Outteryck, Olivier [Hopital Roger Salengro, Department of Neurology, Lille (France); Benadjaoud, Mohamed Amine [Radiation Epidemiology Team, CESP, Centre for Research in Epidemiology and Population Health U1018, Villejuif (France); Maraval, Anne [Hopital Henri Mondor, Department of Neuroradiology, Creteil (France); Decq, Philippe [Hopital Henri Mondor, Department of Neurosurgery, Creteil (France)

    2014-01-15

    To develop automated deformation modelling for the assessment of cerebrospinal fluid (CSF) local volume changes in patients with hydrocephalus treated by surgery. Ventricular and subarachnoid CSF volume changes were mapped by calculating the Jacobian determinant of the deformation fields obtained after non-linear registration of pre- and postoperative images. A total of 31 consecutive patients, 15 with communicating hydrocephalus (CH) and 16 with non-communicating hydrocephalus (NCH), were investigated before and after surgery using a 3D SPACE (sampling perfection with application optimised contrast using different flip-angle evolution) sequence. Two readers assessed CSF volume changes using 3D colour-encoded maps. The Evans index and postoperative volume changes of the lateral ventricles and sylvian fissures were quantified and statistically compared. Before surgery, sylvian fissure and brain ventricle volume differed significantly between CH and NCH (P = 0.001 and P = 0.025, respectively). After surgery, 3D colour-encoded maps allowed for the visual recognition of the CSF volume changes in all patients. The amounts of ventricle volume loss of CH and NCH patients were not significantly different (P = 0.30), whereas readjustment of the sylvian fissure volume was conflicting in CH and NCH patients (P < 0.001). The Evans index correlated with ventricle volume in NCH patients. 3D mapping of CSF volume changes is feasible providing a quantitative follow-up of patients with hydrocephalus. (orig.)

  20. Generalised Exponential Families and Associated Entropy Functions

    Directory of Open Access Journals (Sweden)

    Jan Naudts

    2008-07-01

    Full Text Available A generalised notion of exponential families is introduced. It is based on the variational principle, borrowed from statistical physics. It is shown that inequivalent generalised entropy functions lead to distinct generalised exponential families. The well-known result that the inequality of Cram´er and Rao becomes an equality in the case of an exponential family can be generalised. However, this requires the introduction of escort probabilities.

  1. Exponential Observers for Lotka-Volterra Systems

    Directory of Open Access Journals (Sweden)

    Dr. V. Sundarapandian

    2011-03-01

    Full Text Available This paper solves the exponential observer design problem for Lotka-Volterra systems. Explicitly, Sundarapandian’s theorem (2002 for observer design for exponential observer design is used to solve the nonlinear observer design problem for 2-species, 3-species and 4-species Lotka-Volterra systems. Numerical examples are provided to illustrate the effectiveness of the proposed exponential observer design for the Lotka-Volterra systems.

  2. On the exponentials of some structured matrices

    Energy Technology Data Exchange (ETDEWEB)

    Ramakrishna, Viswanath; Costa, F [Department of Mathematical Sciences and Center for Signals, Systems and Communications, University of Texas at Dallas, PO Box 830688, Richardson, TX 75083 (United States)

    2004-12-03

    This paper provides explicit techniques to compute the exponentials of a variety of structured 4 x 4 matrices. The procedures are fully algorithmic and can be used to find the desired exponentials in closed form. With one exception, they require no spectral information about the matrix being exponentiated. They rely on a mixture of Lie theory and one particular Clifford algebra isomorphism. These can be extended, in some cases, to higher dimensions when combined with techniques such as Givens rotations.

  3. Changes in molar volume and heat capacity of actin upon polymerization.

    Science.gov (United States)

    Quirion, F; Gicquaud, C

    1993-11-01

    We have used densimetry and microcalorimetry to measure the changes in molar volume and heat capacity of the actin molecule during Mg(2+)-induced polymerization. Molar volume is decreased by 720 ml/mol. This result is in contradiction with previous measurements by Ikkai and Ooi [(1966) Science 152, 1756-1757], and by Swezey and Somero [(1985) Biochemistry 24, 852-860]: both of these groups reported increases in actin volume during polymerization, of 391 ml/mol and 63 ml/mol respectively. We also observed a decrease in heat capacity of about 69.5 kJ.K-1.mol-1 during polymerization. This is in agreement with the concept of conformational fluctuation of proteins proposed by Lumry and Gregory [(1989) J.Mol. Liq. 42, 113-144]whereby either ligand binding by a protein or monomer-monomer interaction decreases the protein's conformational flexibility.

  4. Image analysis based quantification of bacterial volume change with high hydrostatic pressure.

    Science.gov (United States)

    Pilavtepe-Celik, M; Balaban, M O; Alpas, H; Yousef, A E

    2008-11-01

    Scanning electron microscopy (SEM) images of Staphylococcus aureus 485 and Escherichia coli O157:H7 933 were taken after pressure treatments at 200 to 400 MPa. Software developed for this purpose was used to analyze SEM images and to calculate the change in view area and volume of cells. Significant increase in average cell view area and volume for S. aureus 485 was observed in response to pressure treatment at 400 MPa. Cell view area for E. coli O157:H7 933 significantly increased at 325 MPa, the maximum pressure treatment tested against this pathogen. In contrast to S. aureus, cells of E. coli O157:H7 exhibited significant increase in average view area and volume at 200 MPa. The pressure-induced increase in these parameters may be attributed to modifications in membrane properties, for example, denaturation of membrane-bound proteins and pressure-induced phase transition of membrane lipid bilayer.

  5. Comparison of gray matter volume and thickness for analysis of cortical changes in Alzheimer's disease

    Science.gov (United States)

    Liu, Jiachao; Li, Ziyi; Chen, Kewei; Yao, Li; Wang, Zhiqun; Li, Kunchen; Guo, Xiaojuan

    2011-03-01

    Gray matter volume and cortical thickness are two indices of concern in brain structure magnetic resonance imaging research. Gray matter volume reflects mixed-measurement information of cerebral cortex, while cortical thickness reflects only the information of distance between inner surface and outer surface of cerebral cortex. Using Scaled Subprofile Modeling based on Principal Component Analysis (SSM_PCA) and Pearson's Correlation Analysis, this study further provided quantitative comparisons and depicted both global relevance and local relevance to comprehensively investigate morphometrical abnormalities in cerebral cortex in Alzheimer's disease (AD). Thirteen patients with AD and thirteen age- and gender-matched healthy controls were included in this study. Results showed that factor scores from the first 8 principal components accounted for ~53.38% of the total variance for gray matter volume, and ~50.18% for cortical thickness. Factor scores from the fifth principal component showed significant correlation. In addition, gray matter voxel-based volume was closely related to cortical thickness alterations in most cortical cortex, especially, in some typical abnormal brain regions such as insula and the parahippocampal gyrus in AD. These findings suggest that these two measurements are effective indices for understanding the neuropathology in AD. Studies using both gray matter volume and cortical thickness can separate the causes of the discrepancy, provide complementary information and carry out a comprehensive description of the morphological changes of brain structure.

  6. Changes to Hospital Inpatient Volume After Newspaper Reporting of Medical Errors.

    Science.gov (United States)

    Fukuda, Haruhisa

    2017-06-30

    The aim of this study was to investigate the influence of medical error case reporting by national newspapers on inpatient volume at acute care hospitals. A case-control study was conducted using the article databases of 3 major Japanese newspapers with nationwide circulation between fiscal years 2012 and 2013. Data on inpatient volume at acute care hospitals were obtained from a Japanese government survey between fiscal years 2011 and 2014. Panel data were constructed and analyzed using a difference-in-differences design. Acute care hospitals in Japan. Hospitals named in articles that included the terms "medical error" and "hospital" were designated case hospitals, which were matched with control hospitals using corresponding locations, nurse-to-patient ratios, and bed numbers. Medical error case reporting in newspapers. Changes to hospital inpatient volume after error reports. The sample comprised 40 case hospitals and 40 control hospitals. Difference-in-differences analyses indicated that newspaper reporting of medical errors was not significantly associated (P = 0.122) with overall inpatient volume. Medical error case reporting by newspapers showed no influence on inpatient volume. Hospitals therefore have little incentive to respond adequately and proactively to medical errors. There may be a need for government intervention to improve the posterror response and encourage better health care safety.

  7. Cell volume regulation in cultured human retinal Muller cells is associated with changes in transmembrane potential.

    Directory of Open Access Journals (Sweden)

    Juan M Fernández

    Full Text Available Müller cells are mainly involved in controlling extracellular homeostasis in the retina, where intense neural activity alters ion concentrations and osmotic gradients, thus favoring cell swelling. This increase in cell volume is followed by a regulatory volume decrease response (RVD, which is known to be partially mediated by the activation of K(+ and anion channels. However, the precise mechanisms underlying osmotic swelling and subsequent cell volume regulation in Müller cells have been evaluated by only a few studies. Although the activation of ion channels during the RVD response may alter transmembrane potential (Vm, no studies have actually addressed this issue in Müller cells. The aim of the present work is to evaluate RVD using a retinal Müller cell line (MIO-M1 under different extracellular ionic conditions, and to study a possible association between RVD and changes in Vm. Cell volume and Vm changes were evaluated using fluorescent probe techniques and a mathematical model. Results show that cell swelling and subsequent RVD were accompanied by Vm depolarization followed by repolarization. This response depended on the composition of extracellular media. Cells exposed to a hypoosmotic solution with reduced ionic strength underwent maximum RVD and had a larger repolarization. Both of these responses were reduced by K(+ or Cl(- channel blockers. In contrast, cells facing a hypoosmotic solution with the same ionic strength as the isoosmotic solution showed a lower RVD and a smaller repolarization and were not affected by blockers. Together, experimental and simulated data led us to propose that the efficiency of the RVD process in Müller glia depends not only on the activation of ion channels, but is also strongly modulated by concurrent changes in the membrane potential. The relationship between ionic fluxes, changes in ion permeabilities and ion concentrations -all leading to changes in Vm- define the success of RVD.

  8. Know your tools - concordance of different methods for measuring brain volume change after ischemic stroke

    Energy Technology Data Exchange (ETDEWEB)

    Yassi, Nawaf; Campbell, Bruce C.V.; Davis, Stephen M.; Bivard, Andrew [The University of Melbourne, Departments of Medicine and Neurology, Melbourne Brain Centre rate at The Royal Melbourne Hospital, Parkville, Victoria (Australia); Moffat, Bradford A.; Steward, Christopher; Desmond, Patricia M. [The University of Melbourne, Department of Radiology, The Royal Melbourne Hospital, Parkville (Australia); Churilov, Leonid [The University of Melbourne, The Florey Institute of Neurosciences and Mental Health, Parkville (Australia); Parsons, Mark W. [University of Newcastle and Hunter Medical Research Institute, Priority Research Centre for Translational Neuroscience and Mental Health, Newcastle (Australia)

    2015-07-15

    Longitudinal brain volume changes have been investigated in a number of cerebral disorders as a surrogate marker of clinical outcome. In stroke, unique methodological challenges are posed by dynamic structural changes occurring after onset, particularly those relating to the infarct lesion. We aimed to evaluate agreement between different analysis methods for the measurement of post-stroke brain volume change, and to explore technical challenges inherent to these methods. Fifteen patients with anterior circulation stroke underwent magnetic resonance imaging within 1 week of onset and at 1 and 3 months. Whole-brain as well as grey- and white-matter volume were estimated separately using both an intensity-based and a surface watershed-based algorithm. In the case of the intensity-based algorithm, the analysis was also performed with and without exclusion of the infarct lesion. Due to the effects of peri-infarct edema at the baseline scan, longitudinal volume change was measured as percentage change between the 1 and 3-month scans. Intra-class and concordance correlation coefficients were used to assess agreement between the different analysis methods. Reduced major axis regression was used to inspect the nature of bias between measurements. Overall agreement between methods was modest with strong disagreement between some techniques. Measurements were variably impacted by procedures performed to account for infarct lesions. Improvements in volumetric methods and consensus between methodologies employed in different studies are necessary in order to increase the validity of conclusions derived from post-stroke cerebral volumetric studies. Readers should be aware of the potential impact of different methods on study conclusions. (orig.)

  9. Volume-of-change cone-beam CT for image-guided surgery

    Science.gov (United States)

    Lee, Junghoon; Webster Stayman, J.; Otake, Yoshito; Schafer, Sebastian; Zbijewski, Wojciech; Khanna, A. Jay; Prince, Jerry L.; Siewerdsen, Jeffrey H.

    2012-08-01

    C-arm cone-beam CT (CBCT) can provide intraoperative 3D imaging capability for surgical guidance, but workflow and radiation dose are the significant barriers to broad utilization. One main reason is that each 3D image acquisition requires a complete scan with a full radiation dose to present a completely new 3D image every time. In this paper, we propose to utilize patient-specific CT or CBCT as prior knowledge to accurately reconstruct the aspects of the region that have changed by the surgical procedure from only a sparse set of x-rays. The proposed methods consist of a 3D-2D registration between the prior volume and a sparse set of intraoperative x-rays, creating digitally reconstructed radiographs (DRRs) from the registered prior volume, computing difference images by subtracting DRRs from the intraoperative x-rays, a penalized likelihood reconstruction of the volume of change (VOC) from the difference images, and finally a fusion of VOC reconstruction with the prior volume to visualize the entire surgical field. When the surgical changes are local and relatively small, the VOC reconstruction involves only a small volume size and a small number of projections, allowing less computation and lower radiation dose than is needed to reconstruct the entire surgical field. We applied this approach to sacroplasty phantom data obtained from a CBCT test bench and vertebroplasty data with a fresh cadaver acquired from a C-arm CBCT system with a flat-panel detector. The VOCs were reconstructed from a varying number of images (10-66 images) and compared to the CBCT ground truth using four different metrics (mean squared error, correlation coefficient, structural similarity index and perceptual difference model). The results show promising reconstruction quality with structural similarity to the ground truth close to 1 even when only 15-20 images were used, allowing dose reduction by the factor of 10-20.

  10. Changes in the temperature-dependent specific volume of supported polystyrene films with film thickness

    Science.gov (United States)

    Huang, Xinru; Roth, Connie B.

    2016-06-01

    Recent studies have measured or predicted thickness-dependent shifts in density or specific volume of polymer films as a possible means of understanding changes in the glass transition temperature Tg(h) with decreasing film thickness with some experimental works claiming unrealistically large (25%-30%) increases in film density with decreasing thickness. Here we use ellipsometry to measure the temperature-dependent index of refraction of polystyrene (PS) films supported on silicon and investigate the validity of the commonly used Lorentz-Lorenz equation for inferring changes in density or specific volume from very thin films. We find that the density (specific volume) of these supported PS films does not vary by more than ±0.4% of the bulk value for film thicknesses above 30 nm, and that the small variations we do observe are uncorrelated with any free volume explanation for the Tg(h) decrease exhibited by these films. We conclude that the derivation of the Lorentz-Lorenz equation becomes invalid for very thin films as the film thickness approaches ˜20 nm, and that reports of large density changes greater than ±1% of bulk for films thinner than this likely suffer from breakdown in the validity of this equation or in the difficulties associated with accurately measuring the index of refraction of such thin films. For larger film thicknesses, we do observed small variations in the effective specific volume of the films of 0.4 ± 0.2%, outside of our experimental error. These shifts occur simultaneously in both the liquid and glassy regimes uniformly together starting at film thicknesses less than ˜120 nm but appear to be uncorrelated with Tg(h) decreases; possible causes for these variations are discussed.

  11. Micro-Computed Tomography of Tooth Volume Changes Following Post Removal.

    Science.gov (United States)

    Kim, Jiyeon J; Alapati, Satish; Knoernschild, Kent L; Jeong, Yong-Hoon; Kim, Do Gyoon; Lee, Damian J

    2017-08-01

    To measure tooth volume change before and after post removal using micro-CT and to compare the difference among various combinations of prefabricated post and cement systems. Forty-eight extracted maxillary anterior teeth and mandibular canines were sectioned 13 mm from the apex. Root canals were properly instrumented. Preparations were filled with gutta percha using lateral condensation. Post space was prepared with a touch and heat device, leaving 5 mm of gutta percha from the apex. Specimens were scanned with micro-CT to establish objective baseline volume and divided into two groups of post systems: stainless steel (SS) ParaPost and glass-fiber reinforced composite (FRC) post. Half the posts for each group were cemented with Ketac Cem radiopaque glass-ionomer cement, and the other half with SpeedCEM dual-curing resin cement. The posts and residual cement were removed by the same operator, using the ultrasonic vibration technique under an endodontic operating microscope. The remaining tooth root structure was scanned again using micro-CT with volume reported (mm(3) ). The statistical difference between the combination of posts and cements was measured using the Kruskal-Wallis ANOVA test (α = 0.001). The independent variables were evaluated separately using post hoc Tukey examination to determine which groups resulted in a statistically significant difference. There was a statistical difference of tooth root volume change among the groups. Post hoc exam revealed a statistically significant difference in tooth root volume change between group 1 (SS + GI) and the other groups (α = 0.0002). Compared to other post and cement combinations, serrated parallel-sided SS posts cemented with GI cement had the most tooth root structure loss upon post removal using the ultrasonic vibration technique. © 2016 by the American College of Prosthodontists.

  12. Improving the clinical correlation of multiple sclerosis black hole volume change by paired-scan analysis.

    Science.gov (United States)

    Tam, Roger C; Traboulsee, Anthony; Riddehough, Andrew; Li, David K B

    2012-01-01

    The change in T 1-hypointense lesion ("black hole") volume is an important marker of pathological progression in multiple sclerosis (MS). Black hole boundaries often have low contrast and are difficult to determine accurately and most (semi-)automated segmentation methods first compute the T 2-hyperintense lesions, which are a superset of the black holes and are typically more distinct, to form a search space for the T 1w lesions. Two main potential sources of measurement noise in longitudinal black hole volume computation are partial volume and variability in the T 2w lesion segmentation. A paired analysis approach is proposed herein that uses registration to equalize partial volume and lesion mask processing to combine T 2w lesion segmentations across time. The scans of 247 MS patients are used to compare a selected black hole computation method with an enhanced version incorporating paired analysis, using rank correlation to a clinical variable (MS functional composite) as the primary outcome measure. The comparison is done at nine different levels of intensity as a previous study suggests that darker black holes may yield stronger correlations. The results demonstrate that paired analysis can strongly improve longitudinal correlation (from -0.148 to -0.303 in this sample) and may produce segmentations that are more sensitive to clinically relevant changes.

  13. Coupled Structural, Thermal, Phase-Change and Electromagnetic Analysis for Superconductors. Volume 1

    Science.gov (United States)

    Felippa, C. A.; Farhat, C.; Park, K. C.; Militello, C.; Schuler, J. J.

    1996-01-01

    Described are the theoretical development and computer implementation of reliable and efficient methods for the analysis of coupled mechanical problems that involve the interaction of mechanical, thermal, phase-change and electromagnetic subproblems. The focus application has been the modeling of superconductivity and associated quantum-state phase-change phenomena. In support of this objective the work has addressed the following issues: (1) development of variational principles for finite elements, (2) finite element modeling of the electromagnetic problem, (3) coupling of thermal and mechanical effects, and (4) computer implementation and solution of the superconductivity transition problem. The main accomplishments have been: (1) the development of the theory of parametrized and gauged variational principles, (2) the application of those principled to the construction of electromagnetic, thermal and mechanical finite elements, and (3) the coupling of electromagnetic finite elements with thermal and superconducting effects, and (4) the first detailed finite element simulations of bulk superconductors, in particular the Meissner effect and the nature of the normal conducting boundary layer. The theoretical development is described in two volumes. This volume, Volume 1, describes mostly formulations for specific problems. Volume 2 describes generalization of those formulations.

  14. Exponentially Localized Wannier Functions in Periodic Zero Flux Magnetic Fields

    CERN Document Server

    De Nittis, Giuseppe

    2011-01-01

    n this work, we investigate conditions which ensure the existence of an exponentially localized Wannier basis for a given periodic hamiltonian. We extend previous results [Pan07, Kuc09] to include periodic zero flux magnetic fields. The new notion of magnetic symmetry plays a crucial r\\^ole; to a large class of symmetries for a non-magnetic system, one can associate "magnetic" symmetries of the related magnetic system. Observing that the existence of an exponentially localized Wannier basis is equivalent to the triviality of the so-called Bloch bundle, a rank m hermitian vector bundle over the Brillouin zone, we prove that magnetic time-reversal symmetry is sufficient to ensure the triviality of the Bloch bundle in spatial dimension d = 1, 2, 3. For d = 4, an exponentially localized Wannier basis exists provided that the trace per unit volume of a suitable function of the Fermi projection vanishes. For d > 4 and d \\leq 2m (stable rank regime) only the exponential localization of a subset of Wannier functions ...

  15. Exponential sensitivity of noise-driven switching in genetic networks

    Science.gov (United States)

    Mehta, Pankaj; Mukhopadhyay, Ranjan; Wingreen, Ned S.

    2008-06-01

    There is increasing experimental evidence that cells can utilize biochemical noise to switch probabilistically between distinct gene-expression states. In this paper, we demonstrate that such noise-driven switching is dominated by tails of probability distributions and is therefore exponentially sensitive to changes in physiological parameters such as transcription and translation rates. Exponential sensitivity limits the robustness of noise-driven switching, suggesting cells may use other mechanisms in order to switch reliably. We discuss our results in the context of competence in the bacterium Bacillus subtilis.

  16. Stereological brain volume changes in post-weaned socially isolated rats

    DEFF Research Database (Denmark)

    Fabricius, Katrine; Helboe, Lone; Steiniger-Brach, Björn;

    2010-01-01

    have evaluated the neuroanatomical changes in this animal model in comparison to changes seen in schizophrenia. In this study, we applied stereological volume estimates to evaluate the total brain, the ventricular system, and the pyramidal and granular cell layers of the hippocampus in male and female...... Lister Hooded rats isolated from postnatal day 25 for 15 weeks. We observed the expected gender differences in total brain volume with males having larger brains than females. Further, we found that isolated males had significantly smaller brains than group-housed controls and larger lateral ventricles...... than controls. However, this was not seen in female rats. Isolated males had a significant smaller hippocampus, dentate gyrus and CA2/3 where isolated females had a significant smaller CA1 compared to controls. Thus, our results indicate that long-term isolation of male rats leads to neuroanatomical...

  17. Vanishing linear term in chemical potential difference in volume term of work of critical nucleus formation for phase transition without volume change

    CERN Document Server

    Mori, Atsushi

    2013-01-01

    A question is given on the form n({\\mu}_{\\beta}-{\\mu}_{\\alpha}) for the volume term of work of formation of critical nucleus. Here, n is the number of molecule undergone the phase transition, {\\mu} denotes the chemical potential, {\\alpha} and {\\beta} represent the parent and nucleating phases, respectively. In this paper we concentrate phase transition without volume change. We have calculated the volume term in terms of the chemical potential difference {\\mu}_{re}-{\\mu}_{eq}$ for this case. Here, {\\mu}_{re} is the chemical potential of the reservoir and {\\mu}_{eq} that at the phase transition. We have W_{vol} = -[({\\kappa}_{\\beta}-{\\kappa}_{\\alpha})/(2v_{eq}^2)] ({\\mu}_{re}-{\\mu}_{eq})^2 V_{\\beta} with {\\kappa} denoting the isothermal compressibility, v_{eq} being the molecular volume at the phase transition, V_{\\beta} the volume of the nucleus.

  18. Universal convergence of the specific volume changes of globular proteins upon unfolding.

    Science.gov (United States)

    Schweiker, Katrina L; Fitz, Victoria W; Makhatadze, George I

    2009-11-24

    Both pressure and temperature are important environmental variables, and to obtain a complete understanding of the mechanisms of protein folding, it is necessary to determine how protein stability is dependent on these fundamental thermodynamic parameters. Although the temperature dependence of protein stability has been widely explored, the dependence of protein stability on pressure is not as well studied. In this paper, we report the results of the direct thermodynamic determination of the change in specific volume (DeltaV/V) upon protein unfolding, which defines the pressure dependence of protein stability, for five model proteins (ubiquitin, eglin c, ribonuclease A, lysozyme, and cytochrome c). We have shown that the specific volumetric changes upon unfolding for four of the proteins (ubiquitin, eglin c, ribonuclease A, and lysozyme) appear to converge to a common value at high temperatures. Analysis of various contributions to the change in volume upon protein unfolding allowed us to put forth the hypothesis that the change in volume due to hydration is very close to zero at this temperature, such that DeltaV/V is defined largely by the total volume of cavities and voids within a protein, and that this is a universal property of all small globular proteins without prosthetic groups. To test this hypothesis, additional experiments were performed with variants of eglin c that had site-directed substitutions at two buried positions, to create an additional cavity in the protein core. The results of these experiments, coupled with the structural analysis of cytochrome c showing a lower packing density compared to those of the other four proteins, provided further support for the hypothesis. Finally, we have shown that the deviation of the high-temperature DeltaV value of a given protein from the convergence value can be used to determine the size of the excess cavities in globular proteins.

  19. An exponential decay model for mediation.

    Science.gov (United States)

    Fritz, Matthew S

    2014-10-01

    Mediation analysis is often used to investigate mechanisms of change in prevention research. Results finding mediation are strengthened when longitudinal data are used because of the need for temporal precedence. Current longitudinal mediation models have focused mainly on linear change, but many variables in prevention change nonlinearly across time. The most common solution to nonlinearity is to add a quadratic term to the linear model, but this can lead to the use of the quadratic function to explain all nonlinearity, regardless of theory and the characteristics of the variables in the model. The current study describes the problems that arise when quadratic functions are used to describe all nonlinearity and how the use of nonlinear functions, such as exponential decay, address many of these problems. In addition, nonlinear models provide several advantages over polynomial models including usefulness of parameters, parsimony, and generalizability. The effects of using nonlinear functions for mediation analysis are then discussed and a nonlinear growth curve model for mediation is presented. An empirical example using data from a randomized intervention study is then provided to illustrate the estimation and interpretation of the model. Implications, limitations, and future directions are also discussed.

  20. The Matrix exponential, Dynamic Systems and Control

    DEFF Research Database (Denmark)

    Poulsen, Niels Kjølstad

    2004-01-01

    The matrix exponential can be found in various connections in analysis and control of dynamic systems. In this short note we are going to list a few examples. The matrix exponential usably pops up in connection to the sampling process, whatever it is in a deterministic or a stochastic setting...

  1. The Ronkin number of an exponential sum

    CERN Document Server

    Silipo, James

    2011-01-01

    We give an intrinsic estimate of the number of connected components of the complementary set to the amoeba of an exponential sum with real spectrum improving the result of Forsberg, Passare and Tsikh in the polynomial case and that of Ronkin in the exponential one.

  2. The Matrix exponential, Dynamic Systems and Control

    DEFF Research Database (Denmark)

    Poulsen, Niels Kjølstad

    2004-01-01

    The matrix exponential can be found in various connections in analysis and control of dynamic systems. In this short note we are going to list a few examples. The matrix exponential usably pops up in connection to the sampling process, whatever it is in a deterministic or a stochastic setting...

  3. On level-transitivity and exponential growth

    OpenAIRE

    Klimann, Ines

    2016-01-01

    We prove that if the group generated by a Mealy automaton acts level-transitively on a regular rooted tree, then the semigroup generated by the dual automaton has exponential growth, hence giving a decision procedure of exponential growth for a restricted family of automaton semigroups.

  4. q-exponentials on quantum spaces

    Energy Technology Data Exchange (ETDEWEB)

    Wachter, H. [Ludwig-Maximilians-Universitaet, Sektion Physik, Muenchen (Germany)

    2004-10-01

    We present explicit formulae for q-exponentials on quantum spaces which could be of particular importance in physics, i.e. the q-deformed Minkowski space and the q-deformed Euclidean space with two, three or four dimensions. Furthermore, these formulae can be viewed as 2-, 3- or 4-dimensional analogues of the well-known q-exponential function. (orig.)

  5. Accounting for uncertainty in volumes of seabed change measured with repeat multibeam sonar surveys

    Science.gov (United States)

    Schimel, Alexandre C. G.; Ierodiaconou, Daniel; Hulands, Lachlan; Kennedy, David M.

    2015-12-01

    Seafloors of unconsolidated sediment are highly dynamic features; eroding or accumulating under the action of tides, waves and currents. Assessing which areas of the seafloor experienced change and measuring the corresponding volumes involved provide insights into these important active sedimentation processes. Computing the difference between Digital Elevation Models (DEMs) obtained from repeat Multibeam Echosounders (MBES) surveys has become a common technique to identify these areas, but the uncertainty in these datasets considerably affects the estimation of the volumes displaced. The two main techniques used to take into account uncertainty in volume estimations are the limitation of calculations to areas experiencing a change in depth beyond a chosen threshold, and the computation of volumetric confidence intervals. However, these techniques are still in their infancy and, as a result, are often crude, seldom used or poorly understood. In this article, we explored a number of possible methodological advances to address this issue, including: (1) using the uncertainty information provided by the MBES data processing algorithm CUBE, (2) adapting fluvial geomorphology techniques for volume calculations using spatially variable thresholds and (3) volumetric histograms. The nearshore seabed off Warrnambool harbour - located in the highly energetic southwest Victorian coast, Australia - was used as a test site. Four consecutive MBES surveys were carried out over a four-months period. The difference between consecutive DEMs revealed an area near the beach experiencing large sediment transfers - mostly erosion - and an area of reef experiencing increasing deposition from the advance of a nearby sediment sheet. The volumes of sediment displaced in these two areas were calculated using the techniques described above, both traditionally and using the suggested improvements. We compared the results and discussed the applicability of the new methodological improvements

  6. Brain gray matter volume changes associated with motor symptoms in patients with Parkinson's disease

    Institute of Scientific and Technical Information of China (English)

    Dezhi Kang; Fuyong Chen; Fangyu Wang; Guorong Wu; Ying Liu; Gang Wu; Lianghong Yu

    2016-01-01

    Background:Parkinson's disease (PD) is a common neurodegenerative disease.Most studies have found that the histopathological lesion is not only localized at the extrapyramidal area (basal ganglia) but also at the cortex in PD patients.Voxel-based morphometry (VBM) based on the voxel as a unit is described for quantitative detection of density and volume of brain tissue.In this study,VBM was used to investigate the brain gray matter changes associated with motor symptoms in PD patients.Methods:Twelve outpatients with PD and 12 healthy controls were recruited in our hospital from September 2013 to March 2014.VBM was performed on the whole brain of all subjects.Image processing and statistical analysis were performed using SPM8.A two-sample t test and multiple regression analysis were performed.Results were displayed with a threshold of P < 0.01,corrected by false discovery rate (FDR) correction and cluster size >30 voxels.Results:Comparing control healthy subjects with the patients,the data showed that PD patients had reduced gray matter volume in the postcentral gyrus,the right supramarginal center,superior temporal gyrus,precentral gyrus,Brodmann area 41,transverse temporal gyrus,Brodmann area 3,and inferior parietal Iobule.The data also found that between gray matter volume and UPDRSIII in PD patients,there were negative correlations in the right middle frontal gyrus,BA06,right precentral gyrus,right superior frontal gyrus,and medial frontal gyrus,and between gray matter volume and Hoehn-Yahr (HY) in PD patients,there were negative correlations in the right middle frontal gyrus,right superior frontal gyrus,BA6,and right precentral gyrus.Conclusions:These data supported that extensive changes associated with motor symptoms in the gray matter volume was mainly located in the related area of movement,which had obvious relevance with the progression of PD.

  7. Hippocampal volume changes in healthy subjects at risk of unipolar depression

    DEFF Research Database (Denmark)

    Baaré, William F C; Vinberg, Maj; Knudsen, Gitte M

    2010-01-01

    Unipolar depression is moderately heritable. It is unclear whether structural brain changes associated with unipolar depression are present in healthy persons at risk of the disorder. Here we investigated whether a genetic predisposition to unipolar depression is associated with structural brain...... changes. A priori, hippocampal volume reductions were hypothesized. Using a high-risk study design, magnetic resonance imaging brain scans were obtained from 59 healthy high-risk subjects having a co-twin with unipolar depression, and 53 healthy low-risk subjects without a first-degree family history...

  8. Heteromeric Slick/Slack K+ channels show graded sensitivity to cell volume changes

    DEFF Research Database (Denmark)

    Tejada, Maria A; Hashem, Nadia; Callø, Kirstine

    2017-01-01

    Slick and Slack high-conductance K+ channels are found in the CNS, kidneys, pancreas, among other organs, where they play an important role in cell excitability as well as in ion transport processes. They are both activated by Na+ and Cl- but show a differential regulation by cell volume changes...... to osmotic challenges. In order to provide with the adequate water permeability to the cell membrane of Xenopus laevis oocytes, mRNA of aquaporin 1 was co-expressed with homomeric or heteromeric Slick and Slack α-subunits. Oocytes were superfused with hypotonic or hypertonic buffers and changes in currents...

  9. Volume and enthalpy changes of proton transfers in the bacteriorhodopsin photocycle studied by millisecond time-resolved photopressure measurements.

    Science.gov (United States)

    Liu, Yan; Edens, Gregory J; Grzymski, Joseph; Mauzerall, David

    2008-07-22

    The volume and enthalpy changes associated with proton translocation steps during the bacteriorhodopsin (BR) photocycle were determined by time-resolved photopressure measurements. The data at 25 degrees C show a prompt increase in volume followed by two further increases and one decrease to the original state to complete the cycle. These volume changes are decomposed into enthalpy and inherent volume changes. The positive enthalpy changes support the argument for inherent entropy-driven late steps in the BR photocycle [Ort, D. R., and Parson, W. M. (1979) Enthalpy changes during the photochemical cycle of bacteriorhodopsin. Biophys. J. 25, 355-364]. The volume change data can be interpreted by the electrostriction effect as charges are canceled and formed during the proton transfers. A simple glutamic acid-glutamate ion model or a diglutamate-arginine-protonated water charge-delocalized model for the proton-release complex (PRC) fit the data. A conformational change with a large positive volume change is required in the slower rise (M --> N of the optical cycle) step and is reversed in the decay (N --> O --> BR) steps. The large variation in the published values for both the volume and enthalpy changes is greatly ameliorated if the values are presented per absorbed photon instead of per mole of BR. Thus, it is the highly differing assumptions about the quantum or reaction yields that cause the variations in the published results.

  10. Volume changes in Alzheimer's disease and mild cognitive impairment: cognitive associations

    Energy Technology Data Exchange (ETDEWEB)

    Evans, Matthew C.; Barnes, Josephine; Nielsen, Casper; Clegg, Shona L.; Blair, Melanie; Douiri, Abdel; Boyes, Richard G.; Fox, Nick C. [UCL Institute of Neurology, Dementia Research Centre, London (United Kingdom); Kim, Lois G. [UCL Institute of Neurology, Dementia Research Centre, London (United Kingdom); London School of Hygiene and Tropical Medicine, London (United Kingdom); Leung, Kelvin K.; Ourselin, Sebastien [UCL Institute of Neurology, Dementia Research Centre, London (United Kingdom); University College London, Centre for Medical Image Computing, London (United Kingdom)

    2010-03-15

    To assess the relationship between MRI-derived changes in whole-brain and ventricular volume with change in cognitive scores in Alzheimer's disease (AD), mild cognitive impairment (MCI) and control subjects. In total 131 control, 231 MCI and 99 AD subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort with T1-weighted volumetric MRIs from baseline and 12-month follow-up were used to derive volume changes. Mini mental state examination (MMSE), Alzheimer's disease assessment scale (ADAS)-cog and trails test changes were calculated over the same period. Brain atrophy rates and ventricular enlargement differed between subject groups (p < 0.0005) and in MCI and AD were associated with MMSE changes. Both measures were additionally associated with ADAS-cog and trails-B in MCI patients, and ventricular expansion was associated with ADAS-cog in AD patients. Brain atrophy (p < 0.0005) and ventricular expansion rates (p = 0.001) were higher in MCI subjects who progressed to AD within 12 months of follow-up compared with MCI subjects who remained stable. MCI subjects who progressed to AD within 12 months had similar atrophy rates to AD subjects. Whole-brain atrophy rates and ventricular enlargement differed between patient groups and healthy controls, and tracked disease progression and psychological decline, demonstrating their relevance as biomarkers. (orig.)

  11. Head posture and pharyngeal airway volume changes after bimaxillary surgery for mandibular prognathism.

    Science.gov (United States)

    Kim, Min-Ah; Kim, Bo-Ram; Youn, Jong-Kuk; Kim, Yoon-Ji R; Park, Yang-Ho

    2014-07-01

    The purpose of this study was to evaluate head posture and the pharyngeal airway volume changes using 3D imaging after bimaxillary surgery in mandibular prognathism patients by null hypothesis. Cone-beam computed tomography (CBCT) scans were obtained for 25 mandibular prognathism patients before bimaxillary surgery (T1) and 6 months after surgery (T2). The head posture of each patient was assessed by measuring cranio-cervical angle on a midsagittal plane passing through the anterior nasal spine at T1 and T2. Additionally, the volume of each subject's pharyngeal airway was measured using InVivoDental 3D imaging software. The cranio-cervical angle increased significantly 6 months after bimaxillary surgery (p  0.05) at the same timepoints, while naso- and oro-pharyngeal airway volume decreased significantly (p Bimaxillary surgery resulted in significant head flexion and a slight decrease in total pharyngeal airway volume. Copyright © 2013 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  12. Variations in gastric compliance induced by acute blood volume changes in anesthetized rats

    Directory of Open Access Journals (Sweden)

    Graça J.R.V.

    2002-01-01

    Full Text Available The impact of acute volume imbalances on gastric volume (GV was studied in anesthetized rats (250-300 g. After cervical and femoral vessel cannulation, a balloon catheter was positioned in the proximal stomach. The opposite end of the catheter was connected to a barostat with an electronic sensor coupled to a plethysmometer. A standard ionic solution was used to fill the balloon (about 3.0 ml and the communicating vessel system, and to raise the reservoir liquid level 4 cm above the animals' xiphoid appendix. Due to constant barostat pressure, GV values were considered to represent the gastric compliance index. All animals were monitored for 90 min. After a basal interval, they were randomly assigned to normovolemic, hypervolemic, hypovolemic or restored protocols. Data were compared by ANOVA followed by Bonferroni's test. Mean arterial pressure (MAP, central venous pressure (CVP and GV values did not change in normovolemic animals (N = 5. Hypervolemic animals (N = 12 were transfused at 0.5 ml/min with a suspension of red blood cells in Ringer-lactate solution with albumin (12.5 ml/kg, which reduced GV values by 11.3% (P0.05. MAP and CVP values increased (P<0.05 after hypervolemia but decreased (P<0.05 with hypovolemia. In conclusion, blood volume level modulates gastric compliance, turning the stomach into an adjustable reservoir, which could be part of the homeostatic process to balance blood volume.

  13. Dynamic volume changes in astrocytes are an intrinsic phenomenon mediated by bicarbonate ion flux.

    Directory of Open Access Journals (Sweden)

    Clare M Florence

    Full Text Available Astrocytes, the major type of non-neuronal cells in the brain, play an important functional role in extracellular potassium ([K(+](o and pH homeostasis. Pathological brain states that result in [K(+](o and pH dysregulation have been shown to cause astrocyte swelling. However, whether astrocyte volume changes occur under physiological conditions is not known. In this study we used two-photon imaging to visualize real-time astrocyte volume changes in the stratum radiatum of the hippocampus CA1 region. Astrocytes were observed to swell by 19.0±0.9% in response to a small physiological increase in the concentration of [K(+](o (3 mM. Astrocyte swelling was mediated by the influx of bicarbonate (HCO(3- ions as swelling was significantly decreased when the influx of HCO(3- was reduced. We found: 1 in HCO(3- free extracellular solution astrocytes swelled by 5.4±0.7%, 2 when the activity of the sodium-bicarbonate cotransporter (NBC was blocked the astrocytes swelled by 8.3±0.7%, and 3 in the presence of an extracellular carbonic anhydrase (CA inhibitor astrocytes swelled by 11.4±0.6%. Because a significant HCO(3- efflux is known to occur through the γ-amino-butyric acid (GABA channel, we performed a series of experiments to determine if astrocytes were capable of HCO(3- mediated volume shrinkage with GABA channel activation. Astrocytes were found to shrink -7.7±0.5% of control in response to the GABA(A channel agonist muscimol. Astrocyte shrinkage from GABA(A channel activation was significantly decreased to -5.0±0.6% of control in the presence of the membrane-permeant CA inhibitor acetazolamide (ACTZ. These dynamic astrocyte volume changes may represent a previously unappreciated yet fundamental mechanism by which astrocytes regulate physiological brain functioning.

  14. CT-measured regional specific volume change reflects regional ventilation in supine sheep.

    Science.gov (United States)

    Fuld, Matthew K; Easley, R Blaine; Saba, Osama I; Chon, Deokiee; Reinhardt, Joseph M; Hoffman, Eric A; Simon, Brett A

    2008-04-01

    Computer tomography (CT) imaging techniques permit the noninvasive measurement of regional lung function. Regional specific volume change (sVol), determined from the change in lung density over a tidal breath, should correlate with regional ventilation and regional lung expansion measured with other techniques. sVol was validated against xenon (Xe)-CT-specific ventilation (sV) in four anesthetized, intubated, mechanically ventilated sheep. Xe-CT used expiratory gated axial scanning during the washin and washout of 55% Xe. sVol was measured from the tidal changes in tissue density (H, houndsfield units) of lung regions using the relationship sVol = [1,000(Hi - He)]/[He(1,000 + Hi)], where He and Hi are expiratory and inspiratory regional density. Distinct anatomical markings were used to define corresponding lung regions of interest between inspiratory, expiratory, and Xe-CT images, with an average region of interest size of 1.6 +/- 0.7 ml. In addition, sVol was compared with regional volume changes measured directly from the positions of implanted metal markers in an additional animal. A linear relationship between sVol and sV was demonstrated over a wide range of regional sV found in the normal supine lung, with an overall correlation coefficient (R(2)) of 0.66. There was a tight correlation (R(2) = 0.97) between marker-measured volume changes and sVol. Regional sVol, which involves significantly reduced exposure to radiation and Xe gas compared with the Xe-CT method, represents a safe and efficient surrogate for measuring regional ventilation in experimental studies and patients.

  15. International conference on the role of the polar regions in global change: Proceedings. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Weller, G.; Wilson, C.L.; Severin, B.A.B. [eds.

    1991-12-01

    The International Conference on the Role of the Polar Regions in Global Change took place on the campus of the University of Alaska Fairbanks on June 11--15, 1990. The goal of the conference was to define and summarize the state of knowledge on the role of the polar regions in global change, and to identify gaps in knowledge. To this purpose experts in a wide variety of relevant disciplines were invited to present papers and hold panel discussions. While there are numerous conferences on global change, this conference dealt specifically with polar regions which occupy key positions in the global system. These two volumes of conference proceedings include papers on (1) detection and monitoring of change; (2) climate variability and climate forcing; (3) ocean, sea ice, and atmosphere interactions and processes; (4) effects on biota and biological feedbacks; (5) ice sheet, glacier and permafrost responses and feedbacks; (6) paleoenvironmental studies; and, (7) aerosols and trace gases.

  16. International conference on the role of the polar regions in global change: Proceedings. Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Weller, G.; Wilson, C.L.; Severin, B.A.B. [eds.

    1991-12-01

    The International Conference on the Role of the Polar Regions in Global Change took place on the campus of the University of Alaska Fairbanks on June 11--15, 1990. The goal of the conference was to define and summarize the state of knowledge on the role of the polar regions in global change, and to identify gaps in knowledge. To this purpose experts in a wide variety of relevant disciplines were invited to present papers and hold panel discussions. While there are numerous conferences on global change, this conference dealt specifically with the polar regions which occupy key positions in the global system. These two volumes of conference proceedings include papers on (1) detection and monitoring of change; (2) climate variability and climate forcing; (3) ocean, sea ice, and atmosphere interactions and processes; and (4) effects on biota and biological feedbacks; (5) ice sheet, glacier and permafrost responses and feedbacks, (6) paleoenvironmental studies; and, (7) aerosol and trace gases.

  17. Coupled Structural, Thermal, Phase-change and Electromagnetic Analysis for Superconductors, Volume 2

    Science.gov (United States)

    Felippa, C. A.; Farhat, C.; Park, K. C.; Militello, C.; Schuler, J. J.

    1996-01-01

    Described are the theoretical development and computer implementation of reliable and efficient methods for the analysis of coupled mechanical problems that involve the interaction of mechanical, thermal, phase-change and electromag subproblems. The focus application has been the modeling of superconductivity and associated quantum-state phase change phenomena. In support of this objective the work has addressed the following issues: (1) development of variational principles for finite elements, (2) finite element modeling of the electromagnetic problem, (3) coupling of thermel and mechanical effects, and (4) computer implementation and solution of the superconductivity transition problem. The main accomplishments have been: (1) the development of the theory of parametrized and gauged variational principles, (2) the application of those principled to the construction of electromagnetic, thermal and mechanical finite elements, and (3) the coupling of electromagnetic finite elements with thermal and superconducting effects, and (4) the first detailed finite element simulations of bulk superconductors, in particular the Meissner effect and the nature of the normal conducting boundary layer. The theoretical development is described in two volumes. Volume 1 describes mostly formulation specific problems. Volume 2 describes generalization of those formulations.

  18. Glacier Volume Change Estimation Using Time Series of Improved Aster Dems

    Science.gov (United States)

    Girod, Luc; Nuth, Christopher; Kääb, Andreas

    2016-06-01

    Volume change data is critical to the understanding of glacier response to climate change. The Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) system embarked on the Terra (EOS AM-1) satellite has been a unique source of systematic stereoscopic images covering the whole globe at 15m resolution and at a consistent quality for over 15 years. While satellite stereo sensors with significantly improved radiometric and spatial resolution are available to date, the potential of ASTER data lies in its long consistent time series that is unrivaled, though not fully exploited for change analysis due to lack of data accuracy and precision. Here, we developed an improved method for ASTER DEM generation and implemented it in the open source photogrammetric library and software suite MicMac. The method relies on the computation of a rational polynomial coefficients (RPC) model and the detection and correction of cross-track sensor jitter in order to compute DEMs. ASTER data are strongly affected by attitude jitter, mainly of approximately 4 km and 30 km wavelength, and improving the generation of ASTER DEMs requires removal of this effect. Our sensor modeling does not require ground control points and allows thus potentially for the automatic processing of large data volumes. As a proof of concept, we chose a set of glaciers with reference DEMs available to assess the quality of our measurements. We use time series of ASTER scenes from which we extracted DEMs with a ground sampling distance of 15m. Our method directly measures and accounts for the cross-track component of jitter so that the resulting DEMs are not contaminated by this process. Since the along-track component of jitter has the same direction as the stereo parallaxes, the two cannot be separated and the elevations extracted are thus contaminated by along-track jitter. Initial tests reveal no clear relation between the cross-track and along-track components so that the latter seems not to be

  19. Effect of Bcl-2 rs956572 polymorphism on age-related gray matter volume changes.

    Directory of Open Access Journals (Sweden)

    Mu-En Liu

    Full Text Available The anti-apoptotic protein B-cell CLL/lymphoma 2 (Bcl-2 gene is a major regulator of neural plasticity and cellular resilience. Recently, the Bcl-2 rs956572 single nucleotide polymorphism was proposed to be a functional allelic variant that modulates cellular vulnerability to apoptosis. Our cross-sectional study investigated the genetic effect of this Bcl-2 polymorphism on age-related decreases in gray matter (GM volume across the adult lifespan. Our sample comprised 330 healthy volunteers (191 male, 139 female with a mean age of 56.2±22.0 years (range: 21-92. Magnetic resonance imaging and genotyping of the Bcl-2 rs956572 were performed for each participant. The differences in regional GM volumes between G homozygotes and A-allele carriers were tested using optimized voxel-based morphometry. The association between the Bcl-2 rs956572 polymorphism and age was a predictor of regional GM volumes in the right cerebellum, bilateral lingual gyrus, right middle temporal gyrus, and right parahippocampal gyrus. We found that the volume of these five regions decreased with increasing age (all P<.001. Moreover, the downward slope was steeper among the Bcl-2 rs956572 A-allele carriers than in the G-homozygous participants. Our data provide convergent evidence for the genetic effect of the Bcl-2 functional allelic variant in brain aging. The rs956572 G-allele, which is associated with significantly higher Bcl-2 protein expression and diminished cellular sensitivity to stress-induced apoptosis, conferred a protective effect against age-related changes in brain GM volume, particularly in the cerebellum.

  20. Acute extracellular fluid volume changes increase ileocolonic resistance to saline flow in anesthetized dogs

    Directory of Open Access Journals (Sweden)

    Santiago Jr. A.T.

    1997-01-01

    Full Text Available We determined the effect of acute extracellular fluid volume changes on saline flow through 4 gut segments (ileocolonic, ileal, ileocolonic sphincter and proximal colon, perfused at constant pressure in anesthetized dogs. Two different experimental protocols were used: hypervolemia (iv saline infusion, 0.9% NaCl, 20 ml/min, volume up to 5% body weight and controlled hemorrhage (up to a 50% drop in mean arterial pressure. Mean ileocolonic flow (N = 6 was gradually and significantly decreased during the expansion (17.1%, P<0.05 and expanded (44.9%, P<0.05 periods while mean ileal flow (N = 7 was significantly decreased only during the expanded period (38%, P<0.05. Mean colonic flow (N = 7 was decreased during expansion (12%, P<0.05 but returned to control levels during the expanded period. Mean ileocolonic sphincter flow (N = 6 was not significantly modified. Mean ileocolonic flow (N = 10 was also decreased after hemorrhage (retracted period by 17% (P<0.05, but saline flow was not modified in the other separate circuits (N = 6, 5 and 4 for ileal, ileocolonic sphincter and colonic groups, respectively. The expansion effect was blocked by atropine (0.5 mg/kg, iv both on the ileocolonic (N = 6 and ileal (N = 5 circuits. Acute extracellular fluid volume retraction and expansion increased the lower gastrointestinal resistances to saline flow. These effects, which could physiologically decrease the liquid volume being supplied to the colon, are possible mechanisms activated to acutely balance liquid volume deficit and excess.

  1. No pituitary gland volume change in medication-free depressed patients.

    Science.gov (United States)

    Eker, Cagdas; Ovali, Gulgun Yilmaz; Ozan, Erol; Eker, Ozlem Donat; Kitis, Omer; Coburn, Kerry; Gonul, Ali Saffet

    2008-10-01

    Increased serum cortisol levels and a hyperactive hypothalamo-pituitary-adrenal (HPA) axis have been proposed to play an important role in the pathophysiology of Major Depressive Disorder (MDD). However, there are inconsistent results regarding pituitary gland volume (PGV), which is one of the key elements of the HPA axis evaluated by MRI in depressed patients. In this study, we analyzed the PGV of medication-free moderately depressed MDD patients (N=34) and age and sex matched healthy controls (N=39). PGV did not differ between MDD patients and healthy controls [mean volume+/-S.D.; 0.76+/-0.17 cm3 and 0.75+/-0.14 cm3; ANCOVA, F1,69=1.25 p>0.05; respectively]. Our results confirm that volumetric PGV changes are not crucial for depression pathophysiology among unmedicated, moderately depressed adults.

  2. Impact of blood volume changes within the human skin on the diffuse reflectance measurements in visible and NIR spectral ranges

    Science.gov (United States)

    Zherebtsov, Evgeny; Bykov, Alexander; Popov, Alexey; Doronin, Alexander; Meglinski, Igor

    2017-03-01

    We consider changes in the volume of blood and oxygen saturation caused by a pulse wave and their influence on the diffuse reflectance spectra in the visible/NIR spectral range. CUDA-based Monte-Carlo model was used for routine simulation of detector depth sensitivity (sampling volume) and skin spectra, and their variations associated with physiological changes in the human skin. The results presented in the form of animated graphs of sampling volume changes for scaling of the parameters of the main human skin layers related to the results of experimental measurements are of particular interest for pulse oximetry, photoplethysmography, Doppler flowmetry, reflectance spectroscopy.

  3. Combination of volume and perfusion parameters reveals different types of grey matter changes in schizophrenia.

    Science.gov (United States)

    Xu, Lixue; Qin, Wen; Zhuo, Chuanjun; Liu, Huaigui; Zhu, Jiajia; Yu, Chunshui

    2017-03-27

    Diverse brain structural and functional changes have been reported in schizophrenia. Identifying different types of brain changes may help to understand the neural mechanisms and to develop reliable biomarkers in schizophrenia. We aimed to categorize different grey matter changes in schizophrenia based on grey matter volume (GMV) and cerebral blood flow (CBF). Structural and perfusion magnetic resonance imaging data were acquired in 100 schizophrenia patients and 95 healthy comparison subjects. Voxel-based GMV comparison was used to show structural changes, CBF analysis was used to demonstrate functional changes. We identified three types of grey matter changes in schizophrenia: structural and functional impairments in the anterior cingulate cortex and insular cortex, displaying reduction in both GMV and CBF; structural impairment with preserved function in the frontal and temporal cortices, demonstrating decreased GMV with normal CBF; pure functional abnormality in the anterior cingulate cortex and lateral prefrontal cortex and putamen, showing altered CBF with normal GMV. By combination of GMV and CBF, we identified three types of grey matter changes in schizophrenia. These findings may help to understand the complex manifestations and to develop reliable biomarkers in schizophrenia.

  4. An Exponential Bound for Cox Regression☆

    Science.gov (United States)

    Kosorok, M. R.

    2012-01-01

    We present an asymptotic exponential bound for the deviation of the survival function estimator of the Cox model. We show that the bound holds even when the proportional hazards assumption does not hold. PMID:23565013

  5. An Exponential Bound for Cox Regression.

    Science.gov (United States)

    Goldberg, Y; Kosorok, M R

    2012-07-01

    We present an asymptotic exponential bound for the deviation of the survival function estimator of the Cox model. We show that the bound holds even when the proportional hazards assumption does not hold.

  6. Influence of Environmental Factors on the Volume Change of Blended Cement Containing Steel Slag

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    In the condition of 20 ℃, 5% sulfate liquor curing, standard tap water curing and 50% RH curing-three different curing environments, the volume change of steel slag blended cement influenced by environmental factors was studied. With steel slag addition 10%, 30%, 50%, from 90 days to 356 days, the relationship of shrinkage and three different curing environments is: dry curing environment>tap water curing environment>sulfate curing environment. But, the sample shrinkage in 28 days has much difference with the curing environment, which has no obvious orderliness. The different effects on blended cement containing steel slag in different environmental factors were analyzed using SEM.

  7. When economic growth is less than exponential

    DEFF Research Database (Denmark)

    Groth, Christian; Koch, Karl-Josef; Steger, Thomas

    2010-01-01

    This paper argues that growth theory needs a more general notion of "regularity" than that of exponential growth. We suggest that paths along which the rate of decline of the growth rate is proportional to the growth rate itself deserve attention. This opens up for considering a richer set of par......) serves as illustration that a continuum of "regular" growth processes fill the whole range between exponential growth and complete stagnation....

  8. When economic growth is less than exponential

    OpenAIRE

    Groth, Christian; Koch, Karl-Josef; Steger, Thomas M.

    2009-01-01

    This paper argues that growth theory needs a more general notion of “regularity” than that of exponential growth. We suggest that paths along which the rate of decline of the growth rate is proportional to the growth rate itself deserve attention. This opens up for considering a richer set of parameter combinations than in standard growth models. And it avoids the usual oversimplistic dichotomy of either exponential growth or stagnation. Allowing zero population growth in three ...

  9. Continued Fraction Algorithm for Matrix Exponentials

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A recursive rational algorithm for matrix exponentials was obtained by making use of the generalized inverse of a matrix in this paper. On the basis of the n-th convergence of Thiele-type continued fraction expansion, a new type of the generalized inverse matrix-valued Padé approximant (GMPA) for matrix exponentials was defined and its remainder formula was proved. The results of this paper were illustrated by some examples.

  10. A new microscopic method to analyse desiccation-induced volume changes in aeroterrestrial green algae.

    Science.gov (United States)

    Lajos, K; Mayr, S; Buchner, O; Blaas, K; Holzinger, A

    2016-08-01

    Aeroterrestrial green algae are exposed to desiccation in their natural habitat, but their actual volume changes have not been investigated. Here, we measure the relative volume reduction (RVRED ) in Klebsormidium crenulatum and Zygnema sp. under different preset relative air humidities (RH). A new chamber allows monitoring RH during light microscopic observation of the desiccation process. The RHs were set in the range of ∼4 % to ∼95% in 10 steps. RVRED caused by the desiccation process was determined after full acclimation to the respective RHs. In K. crenulatum, RVRED (mean ± SE) was 46.4 ± 1.9%, in Zygnema sp. RVRED was only 34.3 ± 2.4% at the highest RH (∼95%) tested. This indicates a more pronounced water loss at higher RHs in K. crenulatum versus Zygnema sp. By contrast, at the lowest RH (∼4%) tested, RVRED ranged from 75.9 ± 2.7% in K. crenulatum to 83.9 ± 2.2% in Zygnema sp. The final volume reduction is therefore more drastic in Zygnema sp. These data contribute to our understanding of the desiccation process in streptophytic green algae, which are considered the closest ancestors of land plants.

  11. Teaching the Verhulst Model: A Teaching Experiment in Covariational Reasoning and Exponential Growth

    Science.gov (United States)

    Castillo-Garsow, Carlos

    2010-01-01

    Both Thompson and the duo of Confrey and Smith describe how students might be taught to build "ways of thinking" about exponential behavior by coordinating the covariation of two changing quantities, however, these authors build exponential behavior from different meanings of covariation. Confrey and Smith advocate beginning with discrete additive…

  12. Critical Random Walk in Random Environment on Trees of Exponential Growth

    OpenAIRE

    Pemantle, Robin

    2004-01-01

    This paper studies the behavior of RWRE on trees in the critical case left open in previous work. For trees of exponential growth, a random perturbation of the transition probabilities can change a transient random walk into a recurrent one. This is the opposite of what occurs on trees of sub-exponential growth.

  13. Blood volume changes after radiotherapy of the CNS; Blutvolumenveraenderungen nach Strahlentherapie des zentralen Nervensystems

    Energy Technology Data Exchange (ETDEWEB)

    Wenz, F. [Radiologische Universitaetsklinik, Heidelberg (Germany); Fuss, M. [Radiologische Universitaetsklinik, Heidelberg (Germany); Scholdei, R. [Radiologische Universitaetsklinik, Heidelberg (Germany); Essig, M. [Abt. Onkologische Diagnostik und Therapie, Deutsches Krebsforschungszentrum, Heidelberg (Germany); Lohr, F. [Radiologische Universitaetsklinik, Heidelberg (Germany); Rempp, K. [Abt. Klinische Neuroradiologie, Univ. Heidelberg (Germany); Brix, G. [Abt. Biophysik und Medizinische Strahlenphysik, Deutsches Krebsforschungszentrum, Heidelberg (Germany); Knopp, M.V. [Abt. Onkologische Diagnostik und Therapie, Deutsches Krebsforschungszentrum, Heidelberg (Germany); Engenhart, R. [Radiologische Universitaetsklinik, Heidelberg (Germany); Wannenmacher, M. [Radiologische Universitaetsklinik, Heidelberg (Germany)

    1996-10-01

    The pathogenesis of late delayed radiation damage in normal brain tissue is most likely due to damage to the vascular endothelium. The mitotic activity of gliomas was shown to correlate with the tumor induced angiogenesis. Dynamic susceptibility contrast MR imaging (DSC MRI) allows the measurement of the cerebral hemodynamics based on the indicator dilution theory. We describe theory and technique of the method and present our experience with blood volume measurements after irradiation of the CNS. We established a double slice technique on a standard 1.5 T MR system without hardware modifications, which allows an absolute quantification of the blood volume in regions of interest (ROI) within the brain. Fifty-five T2* weighted double slice images were acquired before, during and after bolus injection of Gd-DTPA (0.1 mmol/kg in 5 sec.) using a SD FLASH sequence (simultaneous dual fast low angle shot, TR/TE1/TE2 31/16/25, flip angle 10 ). Concentration-time curves were calculated from the measured signal-time curves. Blood volume values in tissue were normalised and calculated in absolute values (ml/100 g) based on the knowledge of the arterial input function (AIF), which was measured in the brain supplying arteries. The whole procedure requires only 2 to 3 minutes, the time for post processing is about 15 to 20 minutes. Blood volume parameter images of representative cases demonstrate the blood volume changes after radiotherapy. A reduction in blood volume could be observed in normal brain tissue and low-grade gliomas, while recurrent tumors were accompanied by a local increase in blood volume. Radiation induced blood volume changes in the CNS can be measured using dynamic susceptibility contrast MR imaging. The measurements in normal brain tissue allow a functional in-vivo analysis of late delayed radiation reactions of the CNS. (orig.) [Deutsch] Die Pathogenese von Strahlenspaetfolgen am Gehirn wird auf eine Schaedigung der Gefaessendothelien zurueckgefuehrt. Die

  14. Separate and combined influence of posture and sprint running on plasma volume changes.

    Science.gov (United States)

    Tsampoukos, Antonios; Stokes, Keith; Nevill, Mary

    2014-01-01

    It is currently unknown whether any changes in plasma volume (PV) after sprint running are inherent to sprint running per se or are due to other confounding factors such as changes in posture. The purpose of the present study was to examine the independent effects of sprint running on PV changes. Eight females completed two trials on separate days: (1) a 30-s sprint on a non-motorised treadmill and (2) a control trial where no exercise was undertaken but blood samples were taken at identical time points as in the exercise trial. Changes in PV were calculated using haematocrit and haemoglobin. Post-sprint PV reductions were greater in the sprint than the control trial (mean: -17.7, SD=3.1% vs. mean: -7.5, s = 4.9, Psprint than the control trial in most sampling points. These data show that sprint running of only 30 s induces transient reductions in PV independently of posture change. The present findings suggest that PV changes due to sprint running should be routinely reported as well as the posture and the exact time in this posture.

  15. Performance Comparison between Nonidentical Segmented Exponential Concave and Nonidentical Segmented Exponential Convex Serrated CATRs

    Directory of Open Access Journals (Sweden)

    T. Venkata Rama Krishna

    2008-01-01

    Full Text Available This paper presented a theoretical and numerical assessment for nonidentical segmented exponential- (NISE- convex and NISE-concave serrated plane CATRs by changing number of serrations. The investigation was based on diffraction theory and, more specifically, on the diffraction formulation of Fresnel. The compact antenna test range (CATR provides uniform illumination within the Fresnel region to the test antenna. Application of serrated edges has been shown to be a good method to control diffraction at the edges of the reflectors. In this paper, the Fresnel fields of NISE-convex and NISE-concave serrated CATRs are analyzed using physical optics (PO technique. The PO analysis is applied in this paper for plane reflector serrated CATR only. The same analysis is applied to any type of reflector. In this paper, lens-based reflector is not considered. It is observed that NISE-concave serrated CATR gives less ripple and enhanced quiet zone width than NISE-convex.

  16. Text Segmentation Using Exponential Models

    CERN Document Server

    Beeferman, D; Lafferty, G D; Beeferman, Doug; Berger, Adam; Lafferty, John

    1997-01-01

    This paper introduces a new statistical approach to partitioning text automatically into coherent segments. Our approach enlists both short-range and long-range language models to help it sniff out likely sites of topic changes in text. To aid its search, the system consults a set of simple lexical hints it has learned to associate with the presence of boundaries through inspection of a large corpus of annotated data. We also propose a new probabilistically motivated error metric for use by the natural language processing and information retrieval communities, intended to supersede precision and recall for appraising segmentation algorithms. Qualitative assessment of our algorithm as well as evaluation using this new metric demonstrate the effectiveness of our approach in two very different domains, Wall Street Journal articles and the TDT Corpus, a collection of newswire articles and broadcast news transcripts.

  17. Pathways of deep cyclones associated with large volume changes (LVCs) and major Baltic inflows (MBIs)

    Science.gov (United States)

    Lehmann, Andreas; Höflich, Katharina; Post, Piia; Myrberg, Kai

    2017-03-01

    Large volume changes (LVCs) and major Baltic inflows (MBIs) are essential processes for the water exchange and renewal of the stagnant water in the Baltic Sea deep basins. These strong inflows are known to be forced by persistent westerly wind conditions. In this study, MBIs are considered as subset of LVCs transporting with the large water volume a big amount of highly saline and oxygenated water into the Baltic Sea. Since the early 1980s the frequency of MBIs has dropped drastically from 5 to 7 events to only one inflow per decade, and long lasting periods without MBIs became the usual state. Only in January 1993, 2003 and December 2014 MBIs occurred that were able to interrupt the stagnation periods in the deep basins of the Baltic Sea. However, in spite of the decreasing frequency of MBIs, there is no obvious decrease of LVCs. The Landsort sea level is known to reflect the mean sea level of the Baltic Sea very well, and hence LVCs have been calculated for the period 1887-2015 filtering daily time series of Landsort sea surface elevation anomalies. The cases with local minimum and maximum difference resulting in at least 60 km3 of water volume change excluding the volume change due to runoff have been chosen for a closer study (1948-2013) of characteristic pathways of deep cyclones. The average duration of LVCs is about 40 days. During this time, 5-6 deep cyclones move along characteristic storm tracks. Furthermore, MBIs are characterized by even higher cyclonic activity compared to average LVCs. We obtained four main routes of deep cyclones which were associated with LVCs, but also with the climatology. One is approaching from the west at about 56-60°N, passing the northern North Sea, northern Denmark, Sweden and the Island of Gotland. A second broad corridor of frequent cyclone pathways enters the study area north of Scotland between 60 and 66°N turning north-eastwards along the northern coast of Scandinavia. This branch bifurcates into smaller routes. One

  18. Accurate tracking of tumor volume change during radiotherapy by CT-CBCT registration with intensity correction

    Science.gov (United States)

    Park, Seyoun; Robinson, Adam; Quon, Harry; Kiess, Ana P.; Shen, Colette; Wong, John; Plishker, William; Shekhar, Raj; Lee, Junghoon

    2016-03-01

    In this paper, we propose a CT-CBCT registration method to accurately predict the tumor volume change based on daily cone-beam CTs (CBCTs) during radiotherapy. CBCT is commonly used to reduce patient setup error during radiotherapy, but its poor image quality impedes accurate monitoring of anatomical changes. Although physician's contours drawn on the planning CT can be automatically propagated to daily CBCTs by deformable image registration (DIR), artifacts in CBCT often cause undesirable errors. To improve the accuracy of the registration-based segmentation, we developed a DIR method that iteratively corrects CBCT intensities by local histogram matching. Three popular DIR algorithms (B-spline, demons, and optical flow) with the intensity correction were implemented on a graphics processing unit for efficient computation. We evaluated their performances on six head and neck (HN) cancer cases. For each case, four trained scientists manually contoured the nodal gross tumor volume (GTV) on the planning CT and every other fraction CBCTs to which the propagated GTV contours by DIR were compared. The performance was also compared with commercial image registration software based on conventional mutual information (MI), VelocityAI (Varian Medical Systems Inc.). The volume differences (mean±std in cc) between the average of the manual segmentations and automatic segmentations are 3.70+/-2.30 (B-spline), 1.25+/-1.78 (demons), 0.93+/-1.14 (optical flow), and 4.39+/-3.86 (VelocityAI). The proposed method significantly reduced the estimation error by 9% (B-spline), 38% (demons), and 51% (optical flow) over the results using VelocityAI. Although demonstrated only on HN nodal GTVs, the results imply that the proposed method can produce improved segmentation of other critical structures over conventional methods.

  19. Changes in gray matter volume after microsurgical lumbar discectomy: A longitudinal analysis

    Directory of Open Access Journals (Sweden)

    Michael eLuchtmann

    2015-02-01

    Full Text Available People around the world suffer chronic lower back pain. Because spine imaging often does not explain the degree of perceived pain reported by patients, the role of the processing of nociceptor signals in the brain as the basis of pain perception is gaining increased attention. Modern neuroimaging techniques (including functional and morphometric methods have produced results that suggest which brain areas may play a crucial role in the perception of acute and chronic pain. In this study, we examined twelve patients with chronic low back pain and sciatica, both resulting from lumbar disc herniation. Structural magnetic resonance imaging (MRI of the brain was performed one day prior to and about four weeks after microsurgical lumbar discectomy. The subsequent MRI revealed an increase in gray matter volume in the basal ganglia but a decrease in volume in the hippocampus, which suggests the complexity of the network that involves movement, pain processing, and aspects of memory. Interestingly, volume changes in the hippocampus were significantly correlated to preoperative pain intensity but not to the duration of chronic pain. Mapping structural changes of the brain that result from lumbar disc herniation has the potential to enhance our understanding of the neuropathology of chronic low back pain and sciatica and therefore may help to optimize the decisions we make about conservative and surgical treatments in the future. The possibility of illuminating more of the details of central pain processing in lumbar disc herniation, as well as the accompanying personal and economic impact of pain relief worldwide, calls for future large-scale clinical studies.

  20. Nasal Drug Absorption from Powder Formulations: Effect of Fluid Volume Changes on the Mucosal Surface.

    Science.gov (United States)

    Tanaka, Akiko; Furubayashi, Tomoyuki; Enomura, Yuki; Hori, Tomoki; Shimomura, Rina; Maeda, Chiaki; Kimura, Shunsuke; Inoue, Daisuke; Kusamori, Kosuke; Katsumi, Hidemasa; Sakane, Toshiyasu; Yamamoto, Akira

    2017-01-01

    The effect of changes in the mucosal fluid volume on the nasal drug absorption of powder formulations was evaluated using warfarin (WF), piroxicam (PXC), and norfloxacin (NFX) as model drugs. Lactose and sodium chloride (NaCl), which are water soluble and small-sized chemicals that increase osmotic pressure after dissolution, were used as excipients to change the mucosal fluid volume. The in vitro study using a Madin-Darby canine kidney (MDCK) cell monolayer indicated that lactose and NaCl, sprayed over the surface of air interface monolayers, increased the fluid volume on the monolayer surface and enhanced the transepithelial transport of the model drugs. The in vivo animal study indicated that the nasal absorption of PXC is enhanced by lactose and NaCl after nasal administration of the powder formulations. This is likely due to the enhanced dissolution of PXC on fluid-rich nasal mucosa and an increase in the effective surface area for drug permeation, which lead to better nasal absorption. However, both excipients failed to increase the nasal absorption of WF and NFX. To clarify the mechanism of the drug-dependent effect of lactose and NaCl, the nasal residence of the formulation was examined using FD70 as a non-absorbable marker. The nasal clearance of FD70 was enhanced by lactose and NaCl, leading to a decrease in the nasal drug absorption. Lactose and NaCl caused no damage to the nasal tissue. These results indicate that the addition of water-soluble excipients such as lactose to powder formulations can enhance the nasal absorption of highly permeable but poorly soluble drugs.

  1. Changes in perceived recovery status scale following high-volume muscle damaging resistance exercise.

    Science.gov (United States)

    Sikorski, Eric M; Wilson, Jacob M; Lowery, Ryan P; Joy, Jordan M; Laurent, C Matthew; Wilson, Stephanie M-C; Hesson, Domini; Naimo, Marshall A; Averbuch, Brian; Gilchrist, Phil

    2013-08-01

    Currently no research has investigated the relationship between muscle damage, hormonal status, and perceived recovery scale (PRS). Therefore, the purpose of this study was to determine the effects of a high-volume training session on PRS and to determine the relationship between levels of testosterone, cortisol, and creatine kinase (CK) and PRS. Thirty-five trained subjects (21.3 ± 1.9 years) were recruited. All subjects participated in a high-volume resistance training session consisting of 3 sets of full squats, bench press, deadlifts, pullups, dips, bent over rows, shoulder press, and barbell curls and extensions. Pre-PRS and post-PRS measurements (0-10), soreness, CK, cortisol, and testosterone were measured before and 48 hours after training. Perceived recovery scale declined from 8.6 ± 2.3 to 4.2 ± 1.85 (p Creatine kinase significantly increased from pre- to postworkout (189.4 ± 100.2 to 512 ± 222.7 U/L). Cortisol, testosterone, and free testosterone did not change. There was an inverse relationship between CK and PRS (r = 0.58, p resistance exercise lowers PRS scores. These changes are partly explained by a rise in serum indices of muscle damage. Moreover, free testosterone seems to have a positive relationship with PRS.

  2. Simulating Longitudinal Brain MRIs with Known Volume Changes and Realistic Variations in Image Intensity.

    Science.gov (United States)

    Khanal, Bishesh; Ayache, Nicholas; Pennec, Xavier

    2017-01-01

    This paper presents a simulator tool that can simulate large databases of visually realistic longitudinal MRIs with known volume changes. The simulator is based on a previously proposed biophysical model of brain deformation due to atrophy in AD. In this work, we propose a novel way of reproducing realistic intensity variation in longitudinal brain MRIs, which is inspired by an approach used for the generation of synthetic cardiac sequence images. This approach combines a deformation field obtained from the biophysical model with a deformation field obtained by a non-rigid registration of two images. The combined deformation field is then used to simulate a new image with specified atrophy from the first image, but with the intensity characteristics of the second image. This allows to generate the realistic variations present in real longitudinal time-series of images, such as the independence of noise between two acquisitions and the potential presence of variable acquisition artifacts. Various options available in the simulator software are briefly explained in this paper. In addition, the software is released as an open-source repository. The availability of the software allows researchers to produce tailored databases of images with ground truth volume changes; we believe this will help developing more robust brain morphometry tools. Additionally, we believe that the scientific community can also use the software to further experiment with the proposed model, and add more complex models of brain deformation and atrophy generation.

  3. Intermediate-depth earthquake faulting by dehydration embrittlement with negative volume change

    Science.gov (United States)

    Jung, Haemyeong; Green, Harry W., II; Dobrzhinetskaya, Larissa F.

    2004-04-01

    Earthquakes are observed to occur in subduction zones to depths of approximately 680km, even though unassisted brittle failure is inhibited at depths greater than about 50km, owing to the high pressures and temperatures. It is thought that such earthquakes (particularly those at intermediate depths of 50-300km) may instead be triggered by embrittlement accompanying dehydration of hydrous minerals, principally serpentine. A problem with failure by serpentine dehydration is that the volume change accompanying dehydration becomes negative at pressures of 2-4GPa (60-120km depth), above which brittle fracture mechanics predicts that the instability should be quenched. Here we show that dehydration of antigorite serpentinite under stress results in faults delineated by ultrafine-grained solid reaction products formed during dehydration. This phenomenon was observed under all conditions tested (pressures of 1-6GPa temperatures of 650-820°C), independent of the sign of the volume change of reaction. Although this result contradicts expectations from fracture mechanics, it can be explained by separation of fluid from solid residue before and during faulting, a hypothesis supported by our observations. These observations confirm that dehydration embrittlement is a viable mechanism for nucleating earthquakes independent of depth, as long as there are hydrous minerals breaking down under a differential stress.

  4. Midlife obesity and trajectories of brain volume changes in older adults.

    Science.gov (United States)

    Driscoll, Ira; Beydoun, May A; An, Yang; Davatzikos, Christos; Ferrucci, Luigi; Zonderman, Alan B; Resnick, Susan M

    2012-09-01

    Although obesity has been linked to structural brain changes, little is known about its associations with the rates of brain atrophy. We examined associations between global (BMI) and central (waist circumference) midlife obesity and subsequent trajectories of regional brain atrophy in 152 individuals [M (age) = 69 ± 7.8] prospectively followed through the Baltimore Longitudinal Study of Aging; 21 individuals became impaired during follow-up. We report no associations (P > 0.05) between either global or central midlife obesity and subsequent rates of regional brain volume changes against a background of age-related atrophy in older individuals who remained nondemented. When looking at the entire sample, greater decline was observed in the volume of gray matter, precuneus, cingulate and orbito-frontal gyri for globally obese (P obesity, a different pattern of results emerged. Overall, our results suggest that midlife obesity may be an important modifier of brain atrophy in individuals who are developing cognitive impairment and dementia, while it has little effect on structural brain integrity in nondemented older adults. Moreover, the discrepancies in findings between studies may be in part due to participant sampling and methodological differences. Published 2011 Wiley Periodicals, Inc.

  5. Entropy and volume change of dissociation in tobacco mosaic virus probed by high pressure.

    Science.gov (United States)

    Bispo, Jose A C; Bonafe, Carlos F S; Joekes, Ines; Martinez, Ernesto A; Carvalho, Giovani B M; Norberto, Douglas R

    2012-12-27

    Virus dissociation and inactivation by high pressure have been extensively studied in recent decades. Pressure-induced dissociation of viral particles involves a reduction in the Gibbs free energy of dissociation and a negative change in volume. In this work, we investigated the combined effect of high pressure and temperature on the dissociation of tobacco mosaic virus (TMV). We assumed the presence of two states of TMV with different tendencies to dissociate. Thus one form presents a low tendency (L) and the other a high tendency (H) to dissociate. Based on the model described here, the L-H transition was favored by an increase in pressure and a decrease in temperature. The volume change of dissociation was pressure- and temperature-dependent, with a highly negative value of -80 mL/mol being recorded at 0 °C and atmospheric pressure. The entropy and enthalpy of dissociation were very temperature- and pressure-dependent, with values of entropy of 450 to -1300 kJ/mol and values of enthalpy of 5.5 × 10(4) to 2.4 × 10(4) kJ/mol. The dissociation of TMV was enthalpy-driven at all temperatures and pressures investigated. Based on these findings, we conclude that the model presented allows accurate predictions of viral dissociation behavior in different experimental conditions.

  6. Three Decades of Volume Change of a Small Greenlandic Glacier Using Ground Penetrating Radar, Structure from Motion, and Aerial Photogrammetry

    DEFF Research Database (Denmark)

    Marcer, M.; Stentoft, Peter Alexander; Bjerre, Elisa

    2017-01-01

    Glaciers in the Arctic are losing mass at an increasing rate. Here we use surface topography derived from Structure from Motion (SfM) and ice volume from ground penetrating radar (GPR) to describe the 2014 state of Aqqutikitsoq glacier (2.85 km) on Greenland's west coast. A photogrammetrically...... topography, the approach constitutes a viable alternative where the use of drones is not possible. Our investigations constitute the first glacier on Greenland's west coast where ice volume was determined and volume change calculated. The glacier's thinning rate is comparable to, for example, the Swiss Alps...... and underlines that arctic glaciers are subject to fast changes....

  7. Local Exponential Methods: a domain decomposition approach to exponential time integration of PDEs

    CERN Document Server

    Bonaventura, Luca

    2015-01-01

    A local approach to the time integration of PDEs by exponential methods is proposed, motivated by theoretical estimates by A.Iserles on the decay of off-diagonal terms in the exponentials of sparse matrices. An overlapping domain decomposition technique is outlined, that allows to replace the computation of a global exponential matrix by a number of independent and easily parallelizable local problems. Advantages and potential problems of the proposed technique are discussed. Numerical experiments on simple, yet relevant model problems show that the resulting method allows to increase computational efficiency with respect to standard implementations of exponential methods.

  8. Fractal structures in a generalized square map with exponential terms

    Institute of Scientific and Technical Information of China (English)

    Li Xian-Feng; Chu Yan-Dong; Zhang Hui

    2012-01-01

    Fractal structures in a generalized squared map with exponential terms are expanded in this paper.We describe how complex behaviors can arise as the parameters change.The appearances of different kinds of fractal structures,in both the attractive and the divergent regions,and most interestingly,on small regular islands embedded in the chaotic region,are manifested to have a variety of extraordinary geometries in the parameter plane.

  9. Epidemic Dynamics with Feedback Mechanism in Exponential Networks

    Institute of Scientific and Technical Information of China (English)

    LIU Zi-Ran; YAN Jia-Ren; ZHANG Jian-Guo; WANG Li

    2006-01-01

    @@ We introduce a feedback mechanism to study the spreading of an epidemic by analytical methods and large scale simulations in exponential networks. It is found that introducing the feedback mechanism can reduce the density of infected individuals. Furthermore, it does not change the epidemic threshold (critical point) λc. These results can help us to understand epidemic spreading phenomena on social networks more practically and design appropriate strategies to control social infections.

  10. Inconsistent detection of changes in cerebral blood volume by near infrared spectroscopy in standard clinical tests.

    Science.gov (United States)

    Canova, D; Roatta, S; Bosone, D; Micieli, G

    2011-06-01

    The attractive possibility of near infrared spectroscopy (NIRS) to noninvasively assess cerebral blood volume and oxygenation is challenged by the possible interference from extracranial tissues. However, to what extent this may affect cerebral NIRS monitoring during standard clinical tests is ignored. To address this issue, 29 healthy subjects underwent a randomized sequence of three maneuvers that differently affect intra- and extracranial circulation: Valsalva maneuver (VM), hyperventilation (HV), and head-up tilt (HUT). Putative intracranial ("i") and extracranial ("e") NIRS signals were collected from the forehead and from the cheek, respectively, and acquired together with cutaneous plethysmography at the forehead (PPG), cerebral blood velocity from the middle cerebral artery, and arterial blood pressure. Extracranial contribution to cerebral NIRS monitoring was investigated by comparing Beer-Lambert (BL) and spatially resolved spectroscopy (SRS) blood volume indicators [the total hemoglobin concentration (tHb) and the total hemoglobin index, (THI)] and by correlating their changes with changes in extracranial circulation. While THIe and tHbe generally provided concordant indications, tHbi and THIi exhibited opposite-sign changes in a high percentage of cases (VM: 46%; HV: 31%; HUT: 40%). Moreover, tHbi was correlated with THIi only during HV (P < 0.05), not during VM and HUT, while it correlated with PPG in all three maneuvers (P < 0.01). These results evidence that extracranial circulation may markedly affect BL parameters in a high percentage of cases, even during standard clinical tests. Surface plethysmography at the forehead is suggested as complementary monitoring helpful in the interpretation of cerebral NIRS parameters.

  11. Volume changes of extremely large and giant intracranial aneurysms after treatment with flow diverter stents

    Energy Technology Data Exchange (ETDEWEB)

    Carneiro, Angelo; Byrne, James V. [ohn Radcliffe Hospital, Oxford Neurovascular and Neuroradiology Research Unit, Nuffield Department of Surgical Sciences, Oxford (United Kingdom); Rane, Neil; Kueker, Wilhelm; Cellerini, Martino; Corkill, Rufus [John Radcliffe Hospital, Department of Neuroradiology, Oxford (United Kingdom)

    2014-01-15

    This study assessed volume changes of unruptured large and giant aneurysms (greatest diameter >20 mm) after treatment with flow diverter (FD) stents. Clinical audit of the cases treated in a single institution, over a 5-year period. Demographic and clinical data were retrospectively collected from the hospital records. Aneurysm volumes were measured by manual outlining at sequential slices using computerised tomography (CT) or magnetic resonance (MR) angiography data. The audit included eight patients (seven females) with eight aneurysms. Four aneurysms involved the cavernous segment of the internal carotid artery (ICA), three the supraclinoid ICA and one the basilar artery. Seven patients presented with signs and symptoms of mass effect and one with seizures. All but one aneurysm was treated with a single FD stent; six aneurysms were also coiled (either before or simultaneously with FD placement). Minimum follow-up time was 6 months (mean 20 months). At follow-up, three aneurysms decreased in size, three were unchanged and two increased. Both aneurysms that increased in size showed persistent endosaccular flow at follow-up MR; in one case, failure was attributed to suboptimal position of the stent; in the other case, it was attributed to persistence of a side branch originating from the aneurysm (similar to the endoleak phenomenon of aortic aneurysms). At follow-up, five aneurysms were completely occluded; none of these increased in volume. Complete occlusion of the aneurysms leads, in most cases, to its shrinkage. In cases of late aneurysm growth or regrowth, consideration should be given to possible endoleak as the cause. (orig.)

  12. Changes in Stroke Volume Induced by Lung Recruitment Maneuver Predict Fluid Responsiveness in Mechanically Ventilated Patients in the Operating Room.

    Science.gov (United States)

    Biais, Matthieu; Lanchon, Romain; Sesay, Musa; Le Gall, Lisa; Pereira, Bruno; Futier, Emmanuel; Nouette-Gaulain, Karine

    2017-02-01

    Lung recruitment maneuver induces a decrease in stroke volume, which is more pronounced in hypovolemic patients. The authors hypothesized that the magnitude of stroke volume reduction through lung recruitment maneuver could predict preload responsiveness. Twenty-eight mechanically ventilated patients with low tidal volume during general anesthesia were included. Heart rate, mean arterial pressure, stroke volume, and pulse pressure variations were recorded before lung recruitment maneuver (application of continuous positive airway pressure of 30 cm H2O for 30 s), during lung recruitment maneuver when stroke volume reached its minimal value, and before and after volume expansion (250 ml saline, 0.9%, infused during 10 min). Patients were considered as responders to fluid administration if stroke volume increased greater than or equal to 10%. Sixteen patients were responders. Lung recruitment maneuver induced a significant decrease in mean arterial pressure and stroke volume in both responders and nonresponders. Changes in stroke volume induced by lung recruitment maneuver were correlated with those induced by volume expansion (r = 0.56; P recruitment maneuver predicted fluid responsiveness with a sensitivity of 88% (95% CI, 62 to 98) and a specificity of 92% (95% CI, 62 to 99). Pulse pressure variations more than 6% before lung recruitment maneuver discriminated responders with a sensitivity of 69% (95% CI, 41 to 89) and a specificity of 75% (95% CI, 42 to 95). The area under receiver operating curves generated for changes in stroke volume induced by lung recruitment maneuver (0.96; 95% CI, 0.81 to 0.99) was significantly higher than that for pulse pressure variations (0.72; 95% CI, 0.52 to 0.88; P recruitment maneuver could predict preload responsiveness in mechanically ventilated patients in the operating room.

  13. ESTIMATION ACCURACY OF EXPONENTIAL DISTRIBUTION PARAMETERS

    Directory of Open Access Journals (Sweden)

    muhammad zahid rashid

    2011-04-01

    Full Text Available The exponential distribution is commonly used to model the behavior of units that have a constant failure rate. The two-parameter exponential distribution provides a simple but nevertheless useful model for the analysis of lifetimes, especially when investigating reliability of technical equipment.This paper is concerned with estimation of parameters of the two parameter (location and scale exponential distribution. We used the least squares method (LSM, relative least squares method (RELS, ridge regression method (RR,  moment estimators (ME, modified moment estimators (MME, maximum likelihood estimators (MLE and modified maximum likelihood estimators (MMLE. We used the mean square error MSE, and total deviation TD, as measurement for the comparison between these methods. We determined the best method for estimation using different values for the parameters and different sample sizes

  14. Modeling aftershocks as a stretched exponential relaxation

    Science.gov (United States)

    Mignan, A.

    2015-11-01

    The decay rate of aftershocks has been modeled as a power law since the pioneering work of Omori in the late nineteenth century. Although other expressions have been proposed in recent decades to describe the temporal behavior of aftershocks, the number of model comparisons remains limited. After reviewing the aftershock models published from the late nineteenth century until today, I solely compare the power law, pure exponential and stretched exponential expressions defined in their simplest forms. By applying statistical methods recommended recently in applied mathematics, I show that all aftershock sequences tested in three regional earthquake catalogs (Southern and Northern California, Taiwan) and with three declustering techniques (nearest-neighbor, second-order moment, window methods) follow a stretched exponential instead of a power law. These results infer that aftershocks are due to a simple relaxation process, in accordance with most other relaxation processes observed in Nature.

  15. Unification modulo a partial theory of exponentiation

    CERN Document Server

    Kapur, Deepak; Narendran, Paliath; 10.4204/EPTCS.42.2

    2010-01-01

    Modular exponentiation is a common mathematical operation in modern cryptography. This, along with modular multiplication at the base and exponent levels (to different moduli) plays an important role in a large number of key agreement protocols. In our earlier work, we gave many decidability as well as undecidability results for multiple equational theories, involving various properties of modular exponentiation. Here, we consider a partial subtheory focussing only on exponentiation and multiplication operators. Two main results are proved. The first result is positive, namely, that the unification problem for the above theory (in which no additional property is assumed of the multiplication operators) is decidable. The second result is negative: if we assume that the two multiplication operators belong to two different abelian groups, then the unification problem becomes undecidable.

  16. ESTIMATION ACCURACY OF EXPONENTIAL DISTRIBUTION PARAMETERS

    Directory of Open Access Journals (Sweden)

    muhammad zahid rashid

    2011-04-01

    Full Text Available The exponential distribution is commonly used to model the behavior of units that have a constant failure rate. The two-parameter exponential distribution provides a simple but nevertheless useful model for the analysis of lifetimes, especially when investigating reliability of technical equipment.This paper is concerned with estimation of parameters of the two parameter (location and scale exponential distribution. We used the least squares method (LSM, relative least squares method (RELS, ridge regression method (RR,  moment estimators (ME, modified moment estimators (MME, maximum likelihood estimators (MLE and modified maximum likelihood estimators (MMLE. We used the mean square error MSE, and total deviation TD, as measurement for the comparison between these methods. We determined the best method for estimation using different values for the parameters and different sample sizes

  17. The technological singularity and exponential medicine

    Directory of Open Access Journals (Sweden)

    Iraj Nabipour

    2016-01-01

    Full Text Available The "technological singularity" is forecasted to occur in 2045. It is a point when non-biological intelligence becomes more intelligent than humans and each generation of intelligent machines re-designs itself smarter. Beyond this point, there is a symbiosis between machines and humans. This co-existence will produce incredible impacts on medicine that its sparkles could be seen in healthcare industry and the future medicine since 2025. Ray Kurzweil, the great futurist, suggested that three revolutions in science and technology consisting genetic and molecular science, nanotechnology, and robotic (artificial intelligence provided an exponential growth rate for medicine. The "exponential medicine" is going to create more disruptive technologies in healthcare industry. The exponential medicine shifts the paradigm of medical philosophy and produces significant impacts on the healthcare system and patient-physician relationship.   

  18. Estimation of volume and mass and of changes in volume and mass of selected chat piles in the Picher mining district, Ottawa County, Oklahoma, 2005-10

    Science.gov (United States)

    Smith, S. Jerrod

    2013-01-01

    From the 1890s through the 1970s the Picher mining district in northeastern Ottawa County, Oklahoma, was the site of mining and processing of lead and zinc ore. When mining ceased in about 1979, as much as 165–300 million tons of mine tailings, locally referred to as “chat,” remained in the Picher mining district. Since 1979, some chat piles have been mined for aggregate materials and have decreased in volume and mass. Currently (2013), the land surface in the Picher mining district is covered by thousands of acres of chat, much of which remains on Indian trust land owned by allottees. The Bureau of Indian Affairs manages these allotted lands and oversees the sale and removal of chat from these properties. To help the Bureau of Indian Affairs better manage the sale and removal of chat, the U.S. Geological Survey, in cooperation with the Bureau of Indian Affairs, estimated the 2005 and 2010 volumes and masses of selected chat piles remaining on allotted lands in the Picher mining district. The U.S. Geological Survey also estimated the changes in volume and mass of these chat piles for the period 2005 through 2010. The 2005 and 2010 chat-pile volume and mass estimates were computed for 34 selected chat piles on 16 properties in the study area. All computations of volume and mass were performed on individual chat piles and on groups of chat piles in the same property. The Sooner property had the greatest estimated volume (4.644 million cubic yards) and mass (5.253 ± 0.473 million tons) of chat in 2010. Five of the selected properties (Sooner, Western, Lawyers, Skelton, and St. Joe) contained estimated chat volumes exceeding 1 million cubic yards and estimated chat masses exceeding 1 million tons in 2010. Four of the selected properties (Lucky Bill Humbah, Ta Mee Heh, Bird Dog, and St. Louis No. 6) contained estimated chat volumes of less than 0.1 million cubic yards and estimated chat masses of less than 0.1 million tons in 2010. The total volume of all

  19. Exponential Polynomial Approximation with Unrestricted Upper Density

    Institute of Scientific and Technical Information of China (English)

    Xiang Dong YANG

    2011-01-01

    We take a new approach to obtaining necessary and sufficient conditions for the incompleteness of exponential polynomials in Lp/α, where Lp/α is the weighted Banach space of complex continuous functions f defined on the real axis (R)satisfying (∫+∞/-∞|f(t)|pe-α(t)dt)1/p, 1 < p < ∞, and α(t) is a nonnegative continuous function defined on the real axis (R). In this paper, the upper density of the sequence which forms the exponential polynomials is not required to be finite. In the study of weighted polynomial approximation, consideration of the case is new.

  20. Metastability of exponentially perturbed Markov chains

    Institute of Scientific and Technical Information of China (English)

    陈大岳; 冯建峰; 钱敏平

    1996-01-01

    A family of irreducible Markov chains on a finite state space is considered as an exponential perturbation of a reducible Markov chain. This is a generalization of the Freidlin-Wentzell theory, motivated by studies of stochastic Ising models, neural network and simulated annealing. It is shown that the metastability is a universal feature for this wide class of Markov chains. The metastable states are simply those recurrent states of the reducible Markov chain. Higher level attractors, related attractive basins and their pyramidal structure are analysed. The logarithmic asymptotics of the hitting time of various sets are estimated. The hitting time over its mean converges in law to the unit exponential distribution.

  1. Exponential Operators, Dobinski Relations and Summability

    CERN Document Server

    Blasiak, P; Horzela, A; Penson, K A; Solomon, A I

    2005-01-01

    We investigate properties of exponential operators preserving the particle number using combinatorial methods developed in order to solve the boson normal ordering problem. In particular, we apply generalized Dobinski relations and methods of multivariate Bell polynomials which enable us to understand the meaning of perturbation-like expansions of exponential operators. Such expansions, obtained as formal power series, are everywhere divergent but the Pade summation method is shown to give results which very well agree with exact solutions got for simplified quantum models of the one mode bosonic systems.

  2. Exponential Data Fitting and its Applications

    CERN Document Server

    Pereyra, Victor

    2010-01-01

    Real and complex exponential data fitting is an important activity in many different areas of science and engineering, ranging from Nuclear Magnetic Resonance Spectroscopy and Lattice Quantum Chromodynamics to Electrical and Chemical Engineering, Vision and Robotics. The most commonly used norm in the approximation by linear combinations of exponentials is the l2 norm (sum of squares of residuals), in which case one obtains a nonlinear separable least squares problem. A number of different methods have been proposed through the years to solve these types of problems and new applications appear

  3. Nonuniform exponential dichotomies and Lyapunov functions

    Science.gov (United States)

    Barreira, Luis; Dragičević, Davor; Valls, Claudia

    2017-05-01

    For the nonautonomous dynamics defined by a sequence of bounded linear operators acting on an arbitrary Hilbert space, we obtain a characterization of the notion of a nonuniform exponential dichotomy in terms of quadratic Lyapunov sequences. We emphasize that, in sharp contrast with previous results, we consider the general case of possibly noninvertible linear operators, thus requiring only the invertibility along the unstable direction. As an application, we give a simple proof of the robustness of a nonuniform exponential dichotomy under sufficiently small linear perturbations.

  4. Arc Tan- Exponential Type Distribution Induced By Stereographic Projection / Bilinear Transformation On Modified Wrapped Exponential Distribution

    Directory of Open Access Journals (Sweden)

    Phani Y.

    2013-05-01

    Full Text Available In this paper we make an attempt to construct a new three parameter linear model, we call this new model as Arc Tan-Exponential Type distribution, by applying Stereographic Projection or equivalently Bilinear transformation on Wrapped Exponential distribution, Probability density and cumulative distribution functions of this new model are presented and their graphs are plotted for various values of parameters.

  5. An Exponential Growth Learning Trajectory: Students' Emerging Understanding of Exponential Growth through Covariation

    Science.gov (United States)

    Ellis, Amy B.; Ozgur, Zekiye; Kulow, Torrey; Dogan, Muhammed F.; Amidon, Joel

    2016-01-01

    This article presents an Exponential Growth Learning Trajectory (EGLT), a trajectory identifying and characterizing middle grade students' initial and developing understanding of exponential growth as a result of an instructional emphasis on covariation. The EGLT explicates students' thinking and learning over time in relation to a set of tasks…

  6. Self-heating probe instrument and method for measuring high temperature melting volume change rate of material

    Science.gov (United States)

    Wang, Junwei; Wang, Zhiping; Lu, Yang; Cheng, Bo

    2013-03-01

    The castings defects are affected by the melting volume change rate of material. The change rate has an important effect on running safety of the high temperature thermal storage chamber, too. But the characteristics of existing measuring installations are complex structure, troublesome operation and low precision. In order to measure the melting volume change rate of material accurately and conveniently, a self-designed measuring instrument, self-heating probe instrument, and measuring method are described. Temperature in heating cavity is controlled by PID temperature controller; melting volume change rate υ and molten density are calculated based on the melt volume which is measured by the instrument. Positive and negative υ represent expansion and shrinkage of the sample volume after melting, respectively. Taking eutectic LiF+CaF2 for example, its melting volume change rate and melting density at 1 123 K are -20.6% and 2 651 kg·m-3 measured by this instrument, which is only 0.71% smaller than literature value. Density and melting volume change rate of industry pure aluminum at 973 K and analysis pure NaCl at 1 123 K are detected by the instrument too. The measure results are agreed with report values. Measuring error sources are analyzed and several improving measures are proposed. In theory, the measuring errors of the change rate and molten density which are measured by the self-designed instrument is nearly 1/20-1/50 of that measured by the refitted mandril thermal expansion instrument. The self-designed instrument and method have the advantages of simple structure, being easy to operate, extensive applicability for material, relatively high accuracy, and most importantly, temperature and sample vapor pressure have little effect on the measurement accuracy. The presented instrument and method solve the problems of complicated structure and procedures, and large measuring errors for the samples with high vapor pressure by existing installations.

  7. Changes in blood volume and response to vaso-active drugs in horizontally casted primates

    Science.gov (United States)

    Dickey, D. T.; Teoh, K. K.; Sandler, H.; Stone, H. L.

    1982-01-01

    Experiments were performed on horizontally casted primates (male rhesus monkeys) in order to note changes in blood volume caused by horizontal restraint, to compare orthostatic tolerance before and after casting using the responses to upright tilting, to begin to uncover the cardiovascular and neural mechanisms involved in deconditioning, and to compare the data with that obtained from bed-rested human subjects and from humans exposed to weightlessness. Bolus injections of norepinephrine of 2.0 microgram/kg, phenylephrine of 4.0 microgram/kg, and nitroprusside of 2.0 microgram/kg were administered; and aortic pressure and heart rate were recorded during the injections. The results indicate that the horizontally casted primate is a valid animal model for studying the effects of simulated zero-G on the human cardiovascular system.

  8. Influence of lung volume, fluid and capillary recruitment during positional changes and exercise on thoracic impedance in heart failure.

    Science.gov (United States)

    Kim, Chul-Ho; Fuglestad, Matthew A; Richert, Maile L Ceridon; Shen, Win K; Johnson, Bruce D

    2014-10-01

    It is unclear how dynamic changes in pulmonary-capillary blood volume (Vc), alveolar lung volume (derived from end-inspiratory lung volume, EILV) and interstitial fluid (ratio of alveolar capillary membrane conductance and pulmonary capillary blood volume, Dm/Vc) influence lung impedance (Z(T)). The purpose of this study was to investigate if positional change and exercise result in increased EILV, Vc and/or lung interstitial fluid, and if Z(T) tracks these variables. 12 heart failure (HF) patients underwent measurements (Z(T), EILV, Vc/Dm) at rest in the upright and supine positions, during exercise and into recovery. Inspiratory capacity was obtained to provide consistent measures of EILV while assessing Z(T). Z(T) increased with lung volume during slow vital capacity maneuvers (p0.05). Impedance appears sensitive to changes in lung volume and body position which appear to generally overwhelm small acute changes in lung fluid when assed dynamically at rest or during exercise. Copyright © 2014 Elsevier B.V. All rights reserved.

  9. Atomistic simulation study of the effect of martensitic transformation volume change on crack-tip material evolution and fracture toughness

    Energy Technology Data Exchange (ETDEWEB)

    Grujicic, M. [Clemson Univ., SC (United States). Dept. of Mechanical Engineering; Lai, S.G. [Clemson Univ., SC (United States). Dept. of Mechanical Engineering; Gumbsch, P. [Max Planck-Institut fur Metallforshung Institut fuer Werstoffwissenshaft, Seestrasse 92, D-7000 Stuttgart I (Germany)

    1997-07-15

    The effect of the sign of the F.C.C.{yields}B.C.C. martensitic transformation volume change in Fe-20Ni on material evolution in a region surrounding the crack tip and the accompanying change in the fracture resistance of the material have been investigated using molecular dynamics simulations. The interaction between atoms has been modeled using the embedded atom method (EAM) interatomic potentials. To obtain both the positive and the negative values of the transformation volume change, small adjustments had to be made in the EAM functions. These changes did not significantly affect of the key materials properties, such as the relative thermodynamic stability of the F.C.C. and B.C.C. structures, elastic constants, (11 anti 2){sub bcc} twin boundary energy, (10 anti 1){sub fcc}/(1 anti 21){sub bcc} interfacial energy, etc. The simulation results show that the sign of the transformation volume change has a profound effect on the material evolution and the path of the advancing crack. When the volume change is negative, the region ahead of the crack tip undergoes the transformation only after the other regions around the crack tip have already transformed. The crack tip undergoes a significant blunting and tends to stay on the original crack plane. In sharp contrast, when the volume change is positive, the region ahead of the crack tip transforms first and significant decohesion along the F.C.C./B.C.C. interfaces takes place. Consequently the crack tends to branch out. The effect of material evolution at the crack tip on the ability of the material to withstand further fracture has been quantified by calculating the Eshelby`s F{sub 1} conservation integral. The sign of the transformation volume change is found to have a major effect on the change of the F{sub 1} integral with the simulation time. (orig.)

  10. Negative Associations between Perceived Training Load, Volume and Changes in Physical Fitness in Professional Soccer Players

    Directory of Open Access Journals (Sweden)

    Asier Los Arcos, Raul Martínez-Santos, Javier Yanci, Jurdan Mendiguchia, Alberto Méndez-Villanueva

    2015-06-01

    Full Text Available The purpose of this study was to examine the usefulness of the rating of perceived exertion training load for monitoring changes in several aerobic fitness and neuromuscular performance variables during 9 weeks of soccer training in young professional players. Nineteen male soccer players (20.2 ± 1.9 years belonging to the same reserve team of a Spanish La Liga Club participated in this study. Countermovement jump (CMJ, CMJ arm swing, single leg CMJ, a sprint running test (i.e., 5 m and 15 m times and an aerobic fitness running test were performed at the start of the pre-season (Test 1 and 9 weeks later (Test 2. During 9 weeks, after each training session and match, players reported their rating of perceived exertion (RPE separately for respiratory (RPEres and leg musculature (RPEmus effort. The training load (TL was calculated by multiplying the RPE value by the duration in minutes of each training session or match. Accumulated RPEmus, and associated TL, as well as accumulated training volume were negatively correlated with the changes in most physical fitness attributes after 9 weeks of training (r = -0.51 to -0.64. Present results suggest that a high perception of leg muscular effort associated with training sessions and matches, as well as an excessive accumulation of training volume (time, can impair the improvement in several physical fitness variables believed to be relevant for on-field soccer performance. Therefore, the independent assessment of leg muscular effort to quantify TL can be an interesting additional monitoring measure in soccer training.

  11. Volume Change Measurement Of Collapsible Soil Stabilized With Lime And Waste Lime

    Directory of Open Access Journals (Sweden)

    Khawla A. Al-Juari

    2013-05-01

    Full Text Available This paper presents a series of laboratory tests to evaluate the effects of lime and waste lime on the volume change and strength characteristics of moderately collapsible soil selected from Al-Rashidia in Mosul city. The tests are performed at different percentages of lime and waste lime of 0, 0.25, 0.5, 1.0, 2.0, 3.0, 4.0, 6.0 and 8.0% by dry weight of soil. One dimensional compression tests are conducted to clarify the influences of relative compaction, compaction water content, vertical stress level and curing time on the volume change and strength characteristics.The results of this study indicated a decrease in the plasticity, swelling potential and swelling pressure of treated soil. The soil became non-plastic at (3&6% of lime and waste lime respectively. Swelling pressure and swelling potential reached to zero at 2% lime and  2&7 days of curing time.Unconfined compressive strength (UCS reached to maximum value at optimum stabilizers content. The UCS of lime treated soil is more than that treated by waste lime at different curing time. The collapse index and potential of treated soil are found less than that of natural soil and decrease with increasing stabilizer content until drop to zero at 2% lime. Collapsing increased continuously with applied stresses, but with curing time reached a maximum value at 2 day. On the other hand, collapsing of treated soil with lime is less than that  of waste lime treated soil at different curing time and stresses.

  12. Changes in lakes water volume and runoff over ungauged Sahelian watersheds

    Science.gov (United States)

    Gal, L.; Grippa, M.; Hiernaux, P.; Peugeot, C.; Mougin, E.; Kergoat, L.

    2016-09-01

    A large part of the Sahel consists of endorheic hydrological systems, where reservoirs and lakes capture surface runoff during the rainy season, making water available during the dry season. Monitoring and understanding the dynamics of these lakes and their relationships to the ecohydrological evolution of the region is important to assess past, present and future changes of water resources in the Sahel. Yet, most of Sahelian watersheds are still ungauged or poorly gauged, which hinders the assessment of the water flows feeding the lakes and the overall runoff over their watershed. In this paper, a methodology is developed to estimate water inflow to lakes for ungauged watersheds. It is tested for the Agoufou lake in the Gourma region in Mali, for which in situ water height measurements and surface areas estimations by remote sensing are simultaneously available. A Height-Volume-Area (HVA) model is developed to relate water volume to water height and lake surface area. This model is combined to daily evaporation and precipitation to estimate water inflow to the lake, which approximates runoff over the whole watershed. The ratio between annual water inflow and precipitation increases over the last sixty years as a result of a significant increase in runoff coefficient over the Agoufou watershed. The method is then extended to derive water inflow to three other Sahelian lakes in Mauritania and Niger. No in situ measurements are available and lake surface areas estimation by remote sensing is the only source of information. Dry season surface area changes and estimated evaporation are used to select a suited VA relationship for each case. It is found that the ratio between annual water inflow and precipitation has also increased in the last 60 years over these watersheds, although trends at the Mauritanian site are not statistically significant. The remote sensing approach developed in this study can be easily applied to recent sensors such as Sentinel-2 or Landsat-8

  13. Radiation-induced changes of brain tissue after radiosurgery in patients with arteriovenous malformations: dose/volume-response relations

    Energy Technology Data Exchange (ETDEWEB)

    Levegruen, S.; Schlegel, W. [Dept. of Medical Physics, German Cancer Research Center (DKFZ), Heidelberg (Germany); Hof, H.; Debus, J. [Dept. of Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg (Germany); Essig, M. [Dept. of Radiology, German Cancer Research Center (DKFZ), Heidelberg (Germany)

    2004-12-01

    Purpose: to evaluate late radiation effects in the brain after radiosurgery of patients with cerebral arteriovenous malformations (AVMs) and to quantify dose/volume-response relations for radiation-induced changes of brain tissue identified on follow-up neuroimaging. Patients and methods: data from 73 AVM patients who had stereotactic linac radiosurgery at DKFZ (German Cancer Research Center), Heidelberg, Germany, were retrospectively analyzed. The endpoint of radiation-induced changes of brain tissue on follow-up magnetic resonance (MR) neuroimaging (i.e., edema and blood-brain-barrier breakdown [BBBB]) was evaluated. Each endpoint was further differentiated into three levels with respect to the extent of the image change (small, intermediate, and large). A previous analysis of the data found correlation of the endpoints with several dose/volume variables (DV) derived from each patient's dose distribution in the brain, including the mean dose in a volume of 20 cm{sup 3} (Dmean20) and the absolute brain volume (including the AVM target) receiving a dose of at least 12 Gy (V12). To quantify dose/volume-response relations, patients were ranked according to DV (i.e., Dmean20 and V12) and classified into four groups of equal size. For each group, the actuarial rates of developing the considered endpoints within 2.5 years after radiosurgery were determined from Kaplan-Meier estimates. The dose/volume-response curves were fitted with a sigmoid-shape logistic function and characterized by DV{sub 50}, the dose for a 50% incidence, and the slope parameter k. Results: dose/volume-response relations, based on two alternative, but correlated, dose distribution variables that are a function of both dose and volume, were observed for radiation-induced changes of brain tissue. DV{sub 50} values of fitted dose/volume-response curves for tissue changes of large extent (e.g., V12{sub 50} = 22.0 {+-} 2.6 cm{sup 3} and Dmean20{sub 50} = 17.8 {+-} 2.0 Gy for the combined endpoint

  14. Exponential parameterization of the neutrino mixing matrix - comparative analysis with different data sets and CP violation

    CERN Document Server

    Zhukovsky, Konstantin

    2016-01-01

    The exponential parameterization of Pontecorvo-Maki-Nakagawa-Sakata mixing matrix for neutrino is used for comparative analysis of different neutrino mixing data. The UPMNS matrix is considered as the element of the SU(3) group and the second order matrix polynomial is constructed for it. The inverse problem of constructing the logarithm of the mixing matrix is addressed. In this way the standard parameterization is related to the exponential parameterization exactly. The exponential form allows easy factorization and separate analysis of the rotation and the CP violation. With the most recent experimental data on the neutrino mixing (May 2016), we calculate the values of the exponential parameterization matrix for neutrinos with account for the CP violation. The complementarity hypothesis for quarks and neutrinos is demonstrated to hold, despite significant change in the neutrino mixing data. The values of the entries of the exponential mixing matrix are evaluated with account for the actual degree of the CP...

  15. Changes in the planning target volume and liver volume dose based on the selected respiratory phase in respiratory-gated radiation therapy for a hepatocellular carcinoma

    Science.gov (United States)

    Lee, Jae-Seung; Im, In-Chul; Kang, Su-Man; Goo, Eun-Hoe; Baek, Seong-Min

    2013-11-01

    The aim of this study was to quantitatively analyze the changes in the planning target volume (PTV) and liver volume dose based on the respiratory phase to identify the optimal respiratory phase for respiratory-gated radiation therapy for a hepatocellular carcinoma (HCC). Based on the standardized procedure for respiratory-gated radiation therapy, we performed a 4-dimensional computed tomography simulation for 0 ˜ 90%, 30 ˜ 70%, and 40 ˜ 60% respiratory phases to assess the respiratory stability (S R ) and the defined PTV i for each respiratory phase i. A treatment plan was established, and the changes in the PTV i and dose volume of the liver were quantitatively analyzed. Most patients (91.5%) passed the respiratory stability test (S R = 0.111 ± 0.015). With standardized respiration training exercises, we were able to minimize the overall systematic error caused by irregular respiration. Furthermore, a quantitative analysis to identify the optimal respiratory phase revealed that when a short respiratory phase (40 ˜ 60%) was used, the changes in the PTV were concentrated inside the center line; thus, we were able to obtain both a PTV margin accounting for respiration and a uniform radiation dose within the PTV.

  16. Three Decades of Volume Change of a Small Greenlandic Glacier Using Ground Penetrating Radar, Structure from Motion, and Aerial Photogrammetry

    DEFF Research Database (Denmark)

    Marcer, M.; Stentoft, Peter Alexander; Bjerre, Elisa

    2017-01-01

    Glaciers in the Arctic are losing mass at an increasing rate. Here we use surface topography derived from Structure from Motion (SfM) and ice volume from ground penetrating radar (GPR) to describe the 2014 state of Aqqutikitsoq glacier (2.85 km) on Greenland's west coast. A photogrammetrically...... topography, the approach constitutes a viable alternative where the use of drones is not possible. Our investigations constitute the first glacier on Greenland's west coast where ice volume was determined and volume change calculated. The glacier's thinning rate is comparable to, for example, the Swiss Alps...

  17. Volume changes at macro- and nano-scale in epoxy resins studied by PALS and PVT experimental techniques

    Energy Technology Data Exchange (ETDEWEB)

    Somoza, A. [IFIMAT-UNCentro, Pinto 399, B7000GHG Tandil (Argentina) and CICPBA, Pinto 399, B7000GHG Tandil (Argentina)]. E-mail: asomoza@exa.unicen.edu.ar; Salgueiro, W. [IFIMAT-UNCentro, Pinto 399, B7000GHG Tandil (Argentina); Goyanes, S. [LPMPyMC, Depto. de Fisica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon I, 1428 Buenos Aires (Argentina); Ramos, J. [Materials and Technology Group, Departamento de Ingenieria Quimica y M. Ambiente, Escuela University Politecnica, Universidad Pais Vasco/Euskal Herriko Unibertsitatea, Pz. Europa 1, 20018 Donostia/San Sebastian (Spain); Mondragon, I. [Materials and Technology Group, Departamento de Ingenieria Quimica y M. Ambiente, Escuela University Politecnica, Universidad Pais Vasco/Euskal Herriko Unibertsitatea, Pz. Europa 1, 20018 Donostia/San Sebastian (Spain)

    2007-02-15

    A systematic study on changes in the volumes at macro- and nano-scale in epoxy systems cured with selected aminic hardeners at different pre-cure temperatures is presented. Free- and macroscopic specific-volumes were measured by PALS and pressure-volume-temperature techniques, respectively. An analysis of the relation existing between macro- and nano-scales of the thermosetting networks developed by the different chemical structures is shown. The result obtained indicates that the structure of the hardeners governs the packing of the molecular chains of the epoxy network.

  18. On exponential growth [of gas breakdown

    DEFF Research Database (Denmark)

    McAllister, Iain Wilson

    1991-01-01

    The agreement obtained between measured breakdown voltages and predicted breakdown values is frequently used as a means of assessing the validity of the theory/model in question. However, owing to the mathematical nature of exponential growth, it is easy to formulate a criterion that provides...

  19. Intersection of the Exponential and Logarithmic Curves

    Science.gov (United States)

    Boukas, Andreas; Valahas, Theodoros

    2009-01-01

    The study of the number of intersection points of y = a[superscript x] and y = log[subscript a]x can be an interesting topic to present in a single-variable calculus class. In this article, the authors present a classroom presentation outline involving the basic algebra and the elementary calculus of the exponential and logarithmic functions. The…

  20. When Economic Growth is Less than Exponential

    DEFF Research Database (Denmark)

    Groth, Christian; Koch, Karl-Josef; Steger, Thomas M.

    This paper argues that growth theory needs a more general notion of "regularity" than that of exponential growth. We suggest that paths along which the rate of decline of the growth rate is proportional to the growth rate itself deserve attention. This opens up for considering a richer set...

  1. Exponential lifetime improvement in topological quantum memories

    Science.gov (United States)

    Bardyn, Charles-Edouard; Karzig, Torsten

    2016-09-01

    We propose a simple yet efficient mechanism for passive error correction in topological quantum memories. Our scheme relies on driven-dissipative ancilla systems which couple to local excitations (anyons) and make them "sink" in energy, with no required interaction among ancillae or anyons. Through this process, anyons created by some thermal environment end up trapped in potential "trenches" that they themselves generate, which can be interpreted as a "memory foam" for anyons. This self-trapping mechanism provides an energy barrier for anyon propagation and removes entropy from the memory by favoring anyon recombination over anyon separation (responsible for memory errors). We demonstrate that our scheme leads to an exponential increase of the memory-coherence time with system size L , up to an upper bound Lmax, which can increase exponentially with Δ /T , where T is the temperature and Δ is some energy scale defined by potential trenches. This results in a double exponential increase of the memory time with Δ /T , which greatly improves over the Arrhenius (single-exponential) scaling found in typical quantum memories.

  2. Couplings and Asymptotic Exponentiality of Exit Times

    Science.gov (United States)

    Brassesco, S.; Olivieri, E.; Vares, M. E.

    1998-10-01

    The goal of this note is simply to call attention to the resulting simplification in the proof of asymptotic exponentiality of exit times in the Freidlin-Wentzell regime (as proved by F. Martinelli et al.) by using the coupling proposed by T. Lindvall and C. Rogers.

  3. A Simple Mechanical Experiment on Exponential Growth

    Science.gov (United States)

    McGrew, Ralph

    2015-01-01

    With a rod, cord, pulleys, and slotted masses, students can observe and graph exponential growth in the cord tension over a factor of increase as large as several hundred. This experiment is adaptable for use either in algebra-based or calculus-based physics courses, fitting naturally with the study of sliding friction. Significant parts of the…

  4. Exponentially tapered Josephson flux-flow oscillator

    DEFF Research Database (Denmark)

    Benabdallah, A.; Caputo, J. G.; Scott, Alwyn C.

    1996-01-01

    We introduce an exponentially tapered Josephson flux-flow oscillator that is tuned by applying a bias current to the larger end of the junction. Numerical and analytical studies show that above a threshold level of bias current the static solution becomes unstable and gives rise to a train of flu......, and (iv) better impedance matching to a load....

  5. Functional Regression for General Exponential Families

    CERN Document Server

    Dou, Wei; Zhou, Harrison H

    2010-01-01

    The paper derives a minimax lower bound for rates of convergence for an infinite-dimensional parameter in an exponential family model. An estimator that achieves the optimal rate is constructed by maximum likelihood on finite-dimensional approximations with parameter dimension that grows with sample size.

  6. Modeling shock waves using exponential interpolation functions with the Least-Squares Finite Element method

    Science.gov (United States)

    Smith, Bradford Scott, Jr.

    The hypothesis of this research is that exponential interpolation functions will approximate fluid properties at shock waves with less error than polynomial interpolation functions. Exponential interpolation functions are derived for the purpose of modeling sharp gradients. General equations for conservation of mass, momentum, and energy for an inviscid flow of a perfect gas are converted to finite element equations using the least-squares method. Boundary conditions and a mesh adaptation scheme are also presented. An oblique shock reflection problem is used as a benchmark to determine whether or not exponential interpolation provides any advantages over Lagrange polynomial interpolation. Using exponential interpolation in elements downstream of a shock and having edges coincident with the shock showed a slight reduction in the solution error. However there was very little qualitative difference between solutions using polynomial and exponential interpolation. Regardless of the type of interpolation used, the shocks were smeared and oscillations were present both upstream and downstream of the shock waves. When a mesh adaptation scheme was implemented, exponential elements adjacent to the shock waves became much smaller and the numerical solution diverged. Changing the exponential elements to polynomial elements yielded a convergent solution. There appears to be no significant advantage to using exponential interpolation in comparison to Lagrange polynomial interpolation.

  7. Quantification of cerebral ventricle volume change of preterm neonates using 3D ultrasound images

    Science.gov (United States)

    Chen, Yimin; Kishimoto, Jessica; Qiu, Wu; de Ribaupierre, Sandrine; Fenster, Aaron; Chiu, Bernard

    2015-03-01

    Intraventricular hemorrhage (IVH) is a major cause of brain injury in preterm neonates. Quantitative measurement of ventricular dilation or shrinkage is important for monitoring patients and in evaluation of treatment options. 3D ultrasound (US) has been used to monitor the ventricle volume as a biomarker for ventricular dilation. However, volumetric quantification does not provide information as to where dilation occurs. The location where dilation occurs may be related to specific neurological problems later in life. For example, posterior horn enlargement, with thinning of the corpus callosum and parietal white matter fibres, could be linked to poor visuo-spatial abilities seen in hydrocephalic children. In this work, we report on the development and application of a method used to analyze local surface change of the ventricles of preterm neonates with IVH from 3D US images. The technique is evaluated using manual segmentations from 3D US images acquired in two imaging sessions. The surfaces from baseline and follow-up were registered and then matched on a point-by-point basis. The distance between each pair of corresponding points served as an estimate of local surface change of the brain ventricle at each vertex. The measurements of local surface change were then superimposed on the ventricle surface to produce the 3D local surface change map that provide information on the spatio-temporal dilation pattern of brain ventricles following IVH. This tool can be used to monitor responses to different treatment options, and may provide important information for elucidating the deficiencies a patient will have later in life.

  8. 食管癌放疗体积变化的临床研究%The Clinical Study in Tumor Volume Change of Esophageal Carcinoma in Radiotherapy

    Institute of Scientific and Technical Information of China (English)

    卢绪菁; 江振龙; 张进; 梁保辉; 文万信

    2012-01-01

    To observe and analysis the rule of esophageal tumor volume changes in 3DCRT with conventional fraction. Methods: This study was performed on eight patients with esophageal cancer who were treated with radical three-dimensional conformal radiotherapy between July 2010 and September 2010. Thoracic contrast-enhanced CT scan were performed-during early RT (second weekend), mid-RT (forth weekend), late-RT (sixth weekend) and at follow-up (1 months after RT completion). ROI-based volumetry was derived by tracing the entire tumor region in each CT slice on the computer work station. Image J software was used to calculate tumor volume. Results: Tumor volume of one patient with poorly differentiated squamous-cell carcinoma increased with rapid tumor cell proliferation rate during radiotherapy time. Tumor volume of another patient had no change with radiotherapy. Tumor volume of the third patient increased in early RT and constantly decreased in subsequent radiotherapy, mostly eliminated in two months after the end of radiotherapy. Other 5 patients had similar tumor volume change during radiotherapy time, whose tumor volumes gradually reduced in the former and had little volume change in the latter. Conclusions: Half-time extinction and recession rate of esophageal carcinoma were calculate with exponential fitting from 5 patients' tumor volume change ,which being 1.27%/d and 44.3d respectively and similar to that of lung cancer and cervical cancer. As a result, the average of tumor volume reduced by one-third after 4 weeks radiotherapy, we should modify radiation plan to avoid the influence by tumor volume change, especially with precise radiotherapy.%目的:观察分析食管癌三维适形常规分割放疗过程中肿瘤体积变化规律.方法:选择2010年7月~2010年9月进行常规分割根治性三维适形放射治疗的8例食管癌患者,在放疗期间第2、4、6周及放疗后1月复查胸部增强扫描CT并采用放疗计划系统融合不同时期的CT

  9. Dynamic changes of foliage growth of Catalpa bungei clones under different nitrogen exponential fertilizations%不同氮素指数施肥下楸树无性系叶片发育动态变化

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    植物的展叶过程是由自身遗传因子决定的,同时又受到多种生态因子的调节。本研究旨在量化不同氮素指数施肥下楸树无性系叶片发育过程中各个参数变化情况,建立叶片生长模型和叶面积模型,分析不同氮素指数施肥与叶片发育的关系。2011年3—8月,在甘肃省天水市小陇山林科所选用2年生楸树无性系组培苗1~4,设置4种水平(CK、尿素6、10、14 g/株)指数施肥处理,记录整个施肥期间叶片叶长、叶宽、叶面积变化情况。结果表明:1)楸树无性系叶片参数变化呈“S冶型曲线,叶片生长过程符合Logistic生长函数模型( P0.8 ) . The best fitting indicator of leaf area model was the product of length í width, and the best fitting method was power function ( for both R2 >0.95 ) . Leaf areas in the development stage for C. bungei clones under different nitrogen exponential fertilizations can be estimated by only measuring leaf length with the linear regression equation LA = -63.801 4 +10.822 9L and power function regression equation LA=0.108L2.45 in practice (for both R2 >0.93).

  10. Early changes of volume and spatial location in target and normal tissues caused by IMRT for cervical cancer.

    Science.gov (United States)

    Chen, Jianwu; Liu, Ping; Chen, Wenjuan; Bai, Penggang; Li, Jiangshan; Ni, Xiaolei; Chen, Kaiqiang; Li, Qixin

    2016-12-01

    To investigate the early changes of volume and spatial location in target and normal tissues caused by intensity-modulated radiotherapy (IMRT) for cervical cancer. Forty patients with cervical cancer were included in this study and treated by IMRT. Computed tomography (CT) was performed before radiotherapy and when the patient had received 27 Gy in 15 fractions. After image registration, the volume of interest (VOI) for the targets and organs at risk was delineated by clinicians on the CT images. Changes of volume, spatial location and Dice similarity were calculated for all VOIs. There were significant changes in gross tumor volume (GTV) in the primary tumor (GTV-T) with t = 8.304 (p<0.01) and visible pelvic lymph nodes (GTV-N) with t = 4.996 (p<0.01) caused by IMRT. The mean volume differences for GTV-T and GTV-N were 38.64% ± 19.50% (range 3.16%-86.49%) and 42.49% ± 25.68% (range 2.79%-87.42%), respectively. Among the organs at risk, the bladder had the greatest volume change with 55.13% ± 33.40% (range 3.25%-116.01%). The Dice similarity for GTV-T and GTV-N was 0.50 ± 0.18 (range 0.10-0.85) and 0.31 ± 0.20 (range 0.00-0.71), respectively. The rectum had the least Dice similarity among the normal tissues, with a mean value of 0.57 ± 0.14 (range 0.18-0.76). There were significant changes in volume and spatial location of the target and normal tissues after 27 Gy IMRT. In order to maintain the radiation dose to the targets and minimize the radiation to normal tissues, it is necessary to modify the radiotherapy planning.

  11. Tubular system volume changes in twitch fibres from toad and rat skeletal muscle assessed by confocal microscopy.

    Science.gov (United States)

    Launikonis, Bradley S; Stephenson, D George

    2002-01-15

    The volume of the extracellular compartment (tubular system) within intact muscle fibres from cane toad and rat was measured under various conditions using confocal microscopy. Under physiological conditions at rest, the fractional volume of the tubular system (t-sys(Vol)) was 1.38 +/- 0.09 % (n = 17), 1.41 +/- 0.09 % (n = 12) and 0.83 +/- 0.07 % (n = 12) of the total fibre volume in the twitch fibres from toad iliofibularis muscle, rat extensor digitorum longus muscle and rat soleus muscle, respectively. In toad muscle fibres, the t-sys(Vol) decreased by 30 % when the tubular system was fully depolarized and decreased by 15 % when membrane cholesterol was depleted from the tubular system with methyl-beta-cyclodextrin but did not change as the sarcomere length was changed from 1.93 to 3.30 microm. There was also an increase by 30 % and a decrease by 25 % in t-sys(Vol) when toad fibres were equilibrated in solutions that were 2.5-fold hypertonic and 50 % hypotonic, respectively. When the changes in total fibre volume were taken into consideration, the t-sys(Vol) expressed as a percentage of the isotonic fibre volume did actually decrease as tonicity increased, revealing that the tubular system in intact fibres cannot be compressed below 0.9 % of the isotonic fibre volume. The results can be explained in terms of forces acting at the level of the tubular wall. These observations have important physiological implications showing that the tubular system is a dynamic membrane structure capable of changing its volume in response to the membrane potential, cholesterol depletion and osmotic stress but not when the sarcomere length is changed in resting muscle.

  12. Cell volume changes affect gluconeogenesis in the perfused liver of the catfish Clarias batrachus

    Indian Academy of Sciences (India)

    Carina Goswami; Shritapa Datta; Kuheli Biswas; Nirmalendu Saha

    2004-09-01

    In addition to lactate and pyruvate, some amino acids were found to serve as potential gluconeogenic substrates in the perfused liver of Clarias batrachus. Glutamate was found to be the most effective substrate, followed by lactate, pyruvate, serine, ornithine, proline, glutamine, glycine, and aspartate. Four gluconeogenic enzymes, namely phosphoenolpyruvate carboxykinase (PEPCK), pyruvate carboxylase (PC), fructose 1,6-bisphosphatase (FBPase) and glucose 6-phosphatase (G6Pase) could be detected mainly in liver and kidney, suggesting that the latter are the two major organs responsible for gluconeogenic activity in this fish. Hypo-osmotically induced cell swelling caused a significant decrease of gluconeogenic efflux accompanied with significant decrease of activities of PEPCK, FBPase and G6Pase enzymes in the perfused liver. Opposing effects were seen in response to hyper-osmotically induced cell shrinkage. These changes were partly blocked in the presence of cycloheximide, suggesting that the aniso-osmotic regulations of gluconeogenesis possibly occurs through an inverse regulation of enzyme proteins and/or a regulatory protein synthesis in this catfish. In conclusion, gluconeogenesis appears to play a vital role in C. batrachus in maintaining glucose homeostasis, which is influenced by cell volume changes possibly for proper energy supply under osmotic stress.

  13. Volume and expansivity changes of micelle formation measured by pressure perturbation calorimetry.

    Science.gov (United States)

    Fan, Helen Y; Nazari, Mozhgan; Chowdhury, Saria; Heerklotz, Heiko

    2011-03-01

    We present the application of pressure perturbation calorimetry (PPC) as a new method for the volumetric characterization of the micelle formation of surfactants. The evaluation is realized by a global fit of PPC curves at different surfactant concentration ranging, if possible, from below to far above the CMC. It is based on the knowledge of the temperature dependence of the CMC, which can for example be characterized by isothermal titration calorimetry. We demonstrate the new approach for decyl-β-maltopyranoside (DM). It shows a strong volume increase upon micelle formation of 16 ± 2.5 mL/mol (+4%) at 25 °C, and changes with temperature by -0.1 mL/(mol K). The apparent molar expansivity (E(S)) decreases upon micelle formation from 0.44 to 0.31 mL/(mol K) at 25 °C. Surprisingly, the temperature dependence of the expansivity of DM in solution (as compared with that of maltose) does not agree with the principal behavior described for polar (E(S)(T) decreasing) and hydrophobic (E(S)(T) increasing) solutes or moieties before. The results are discussed in terms of changes in hydration of the molecules and internal packing of the micelles and compared with the volumetric effects of transitions of proteins, DNA, lipids, and polymers.

  14. Effect of temperature on volume change behaviour of statically compacted kaolin clay

    Directory of Open Access Journals (Sweden)

    Ileme Ogechi

    2016-01-01

    Full Text Available Several soils are subjected to high temperature due to the environment where they are located or activities around them. For instance, upper layer of soils in tropical regions, soils around geothermal structures, clay barriers around nuclear waste repository systems. Numerous studies have pointed out that high temperature affects the hydro-mechanical properties of soils. Notwithstanding already existing studies, the influence of temperature on soils is still a challenge, as most of these studies are soil specific and cannot be inferred as the behaviour of all soils. This paper presents an experimental study on the influence of temperature on the volume change behaviour of statically compacted kaolin clay. Compacted samples were tested at varying temperatures using a suction controlled oedometer cell. The influence of temperature on the magnitude of volumetric strain occurring during mechanical and thermal loading was investigated. The study showed that an increase in temperature increased the magnitude of volumetric strain of the soil on loading. Additionally, the results presented in the light of LC curve showed that an increase in temperature resulted in the contraction and a change in the position of the LC curve.

  15. Traditional Medicare Versus Private Insurance: How Spending, Volume, And Price Change At Age Sixty-Five.

    Science.gov (United States)

    Wallace, Jacob; Song, Zirui

    2016-05-01

    To slow the growth of Medicare spending, some policy makers have advocated raising the Medicare eligibility age from the current sixty-five years to sixty-seven years. For the majority of affected adults, this would delay entry into Medicare and increase the time they are covered by private insurance. Despite its policy importance, little is known about how such a change would affect national health care spending, which is the sum of health care spending for all consumers and payers-including governments. We examined how spending differed between Medicare and private insurance using longitudinal data on imaging and procedures for a national cohort of individuals who switched from private insurance to Medicare at age sixty-five. Using a regression discontinuity design, we found that spending fell by $38.56 per beneficiary per quarter-or 32.4 percent-upon entry into Medicare at age sixty-five. In contrast, we found no changes in the volume of services at age sixty-five. For the previously insured, entry into Medicare led to a large drop in spending driven by lower provider prices, which may reflect Medicare's purchasing power as a large insurer. These findings imply that increasing the Medicare eligibility age may raise national health care spending by replacing Medicare coverage with private insurance, which pays higher provider prices than Medicare does.

  16. Whole brain volume changes and its correlation with clinical symptom severity in patients with schizophrenia: A DARTEL-based VBM study.

    Science.gov (United States)

    Kim, Gwang-Won; Kim, Yun-Hyeon; Jeong, Gwang-Woo

    2017-01-01

    The purpose of this study was to evaluate gray matter (GM) and white matter (WM) volume alterations in whole-brain structures in patients with schizophrenia and healthy controls using voxel-based morphometry (VBM), and further to assess the correlation between GM and WM volume variations and symptom severity in schizophrenia. A total of 22 patients with schizophrenia and 22 age-matched healthy controls participated. Magnetic resonance image data were processed using SPM8 software with diffeomorphic anatomical registration via an exponentiated Lie algebra (DARTEL) algorithm. Patients with schizophrenia exhibited significantly decreased GM volumes of the insula, superior temporal gyrus (STG), gyrus rectus, and anterior cingulate cortex (ACC) compared with healthy controls. The GM volumes of the STG and gyrus rectus were negatively correlated with the positive scales on the Positive and Negative Syndrome Scale (PANSS) and those of the STG and ACC were negatively correlated with the negative scales. The durations of illness in schizophrenia were negatively correlated with the GM volumes of the insula, STG, and ACC. Patients with schizophrenia exhibited significantly decreased WM volumes of the superior frontal gyrus, inferior temporal gyrus, and STG. The WM volumes of the STG were negatively correlated with the duration of illness. Our findings suggest that GM and WM volume abnormalities in the STG are associated with the psychopathology of schizophrenia.

  17. Resistance exercise-induced fluid shifts: change in active muscle size and plasma volume

    Science.gov (United States)

    Ploutz-Snyder, L. L.; Convertino, V. A.; Dudley, G. A.

    1995-01-01

    The purpose of this study was to test the hypothesis that the reduction in plasma volume (PV) induced by resistance exercise reflects fluid loss to the extravascular space and subsequently selective increase in cross-sectional area (CSA) of active but not inactive skeletal muscle. We compared changes in active and inactive muscle CSA and PV after barbell squat exercise. Magnetic resonance imaging (MRI) was used to quantify muscle involvement in exercise and to determine CSA of muscle groups or individual muscles [vasti (VS), adductor (Add), hamstring (Ham), and rectus femoris (RF)]. Muscle involvement in exercise was determined using exercise-induced contrast shift in spin-spin relaxation time (T2)-weighted MR images immediately postexercise. Alterations in muscle size were based on the mean CSA of individual slices. Hematocrit, hemoglobin, and Evans blue dye were used to estimate changes in PV. Muscle CSA and PV data were obtained preexercise and immediately postexercise and 15 and 45 min thereafter. A hierarchy of muscle involvement in exercise was found such that VS > Add > Ham > RF, with the Ham and RF showing essentially no involvement. CSA of the VS and Add muscle groups were increased 10 and 5%, respectively, immediately after exercise in each thigh with no changes in Ham and RF CSA. PV was decreased 22% immediately following exercise. The absolute loss of PV was correlated (r2 = 0.75) with absolute increase in muscle CSA immediately postexercise, supporting the notion that increased muscle size after resistance exercise reflects primarily fluid movement from the vascular space into active but not inactive muscle.

  18. Diffusion-weighted MR imaging of metastatic abdominal and pelvic tumours is sensitive to early changes induced by a VEGF inhibitor using alternative diffusion attenuation models

    Energy Technology Data Exchange (ETDEWEB)

    Orton, Matthew R. [Institute of Cancer Research and Royal Marsden NHS Foundation Trust, CRUK and EPSRC Cancer Imaging Centre, Sutton, Surrey (United Kingdom); Institute of Cancer Research, Sutton, Surrey (United Kingdom); Messiou, Christina; DeSouza, Nandita [Institute of Cancer Research and Royal Marsden NHS Foundation Trust, CRUK and EPSRC Cancer Imaging Centre, Sutton, Surrey (United Kingdom); Royal Marsden NHS Foundation Trust, Department of Radiology, Sutton, Surrey (United Kingdom); Collins, David; Leach, Martin O. [Institute of Cancer Research and Royal Marsden NHS Foundation Trust, CRUK and EPSRC Cancer Imaging Centre, Sutton, Surrey (United Kingdom); Morgan, Veronica A. [Royal Marsden NHS Foundation Trust, Department of Radiology, Sutton, Surrey (United Kingdom); Tessier, Jean; Young, Helen [Early Clinical Development, AstraZeneca, Macclesfield (United Kingdom)

    2016-05-15

    To assess the utility of diffusion weighted imaging for monitoring early treatment effects associated with a VEGF inhibitor. Twenty-nine patients with metastatic abdominal and pelvic tumours were recruited and imaged with DW-MRI: twice at baseline, and after 7 and 28 days of treatment with cediranib. Tumour measures were derived using mono-exponential, bi-exponential and stretched-exponential models, and parameter repeatability and treatment effects seen after 7 and 28 days were assessed. Correlations with volume changes and DCE-MRI metrics were also assessed. Diffusion coefficient repeatabilities from all models were < 6 %; f and D* (bi-exponential) were 22 % and 44 %; α (stretched-exponential) was 4.2 %. Significant increases in the diffusion coefficients from all models were observed at day 28 but not day 7. Significant decreases in D* and f.D* were observed at day 7 and in f at day 28; significant increases in α were observed at both time-points. Weak correlations between DW-MRI changes and volume changes and DCE-MRI changes were observed. DW-MRI is sensitive to early and late treatment changes caused by a VEGF inhibitor using non-mono-exponential models. Evidence of over-fitting using the bi-exponential model suggests that the stretched-exponential model is best suited to monitor such changes. (orig.)

  19. Variations of the earth's magnetic field and rapid climatic cooling: A possible link through changes in global ice volume

    Science.gov (United States)

    Rampino, M. R.

    1979-01-01

    A possible relationship between large scale changes in global ice volume, variations in the earth's magnetic field, and short term climatic cooling is investigated through a study of the geomagnetic and climatic records of the past 300,000 years. The calculations suggest that redistribution of the Earth's water mass can cause rotational instabilities which lead to geomagnetic excursions; these magnetic variations in turn may lead to short-term coolings through upper atmosphere effects. Such double coincidences of magnetic excursions and sudden coolings at times of ice volume changes have occurred at 13,500, 30,000, 110,000, and 135,000 YBP.

  20. Expression Changes of Early Response Genes in Lung Due to High Volume Ventilation

    Institute of Scientific and Technical Information of China (English)

    WANG Yuelan; YAO Shanglong; XIONG Ping

    2005-01-01

    Summary: The expression changes of early response genes due to ventilation with high volume in adult rats in vivo were observed. Forty SD male rats were randomly divided into control and 30, 60, 90 and 120 min ventilation groups, respectively (n=8 in each group). The animals were ventilated with tidal volume of 42 ml/kg and a PEEP level of 0 cmH2O at a rate of 40 breaths per minute in room air with a ventilator was given to the small animals. The expression of Egr-1, C-jun and IL-1β mRNA and proteins was detected by RT-PCR and immunohistochemical technique, respectively. The pathological changes in lung tissues were examined by HE staining. The results indicated that the expression of Egr-1, C-jun and IL-1β mRNA was detectable at 30th min after overventilation, but there was no significant difference in comparison with that in control group until overventilation for 60 min. However, at 90 and 120 min there was a significent increase as compared with 30 min or control group (P<0.05). The expression of Egr-1, C-jun and IL-1β deteced by immunohistochemical assay also showed a similar tendency of the gradual increase. In the 120 min ventilation group, the expression intensity of Egr-1, C-jun and IL-1β proteins in lung cells was the strongest and the nuclear translocation was increased markedly in comparison with any other groups (P<0.05). HE staining suggested that the degree of lung injury was aggravated gradually with the ventialtion going on and had a similar tendency to the expression of these early response genes and proteins. The current data suggested that overventilation activated and upregulated the expression of early response genes and the expression of these genes may be taken as the early signal to predict the onset and degree of lung injury. These results may demonstrated partially that the expression of early response genes induced by the mechanical stretch is associated with biochamic lung injury.

  1. Changes of orbital tissue volumes and proptosis in patients with thyroid extraocular muscle swelling after methylprednisolone pulse therapy.

    Science.gov (United States)

    Higashiyama, Tomoaki; Nishida, Yasuhiro; Ohji, Masahito

    2015-11-01

    To evaluate the changes of orbital tissue volumes and proptosis after methylprednisolone pulse therapy in thyroid-associated ophthalmopathy (TAO). The cross-sectional areas of orbital tissues and proptosis were measured with magnetic resonance imaging in 40 orbits of 20 patients with TAO before and after methylprednisolone pulse therapy. The volumes of the whole orbit, orbital fatty tissue, and extraocular muscles were calculated. The volumes and proptosis were compared before and after treatment using a paired t test. Before treatment, the mean volumes were 33.0 ± 4.8 cm(3) in the whole orbit, 19.9 ± 4.1 cm(3) in the orbital fatty tissue, and 4.6 ± 1.2 cm(3) in the total extraocular muscles. After treatment, the mean volumes were 32.5 ± 4.4 cm(3) in the whole orbit, 19.9 ± 3.7 cm(3) in the orbital fatty tissue, and 4.0 ± 1.0 cm(3) in the total extraocular muscles. The mean volumes of the whole orbit (P = 0.17) and orbital fatty tissue (P = 0.82) were not significantly decreased after treatment, while the mean volume of total extraocular muscles was significantly decreased (P tissue seemed to be unchanged after methylprednisolone pulse therapy while that of total extraocular muscles was decreased. The proptosis value seemed to be unchanged after treatment.

  2. Multi-exponentially Photoelectric Response of Bacteriorhodopsin

    Institute of Scientific and Technical Information of China (English)

    姚保利; 徐大纶; 侯洵; 胡坤生; 王敖金

    2001-01-01

    A thin oriented bacteriorhodopsin (bR) film is deposited on a stainless steel slide by use of the electrophoretic sedimentation method. A junction is made with electrolyte gels having a counterelectrode to construct a bRbased photoelectric detector. The photoelectric response signal to a 10ns laser pulse is measured. A theory on the photoelectric kinetics of bR is developed based on the concept of the charge displacement current and the bR photocycle rate equations. Comparison between the theoretical and experimental results proves that the bR photoelectric response to a short laser pulse is a multi-exponential process. The decay time constants and amplitudes of each exponential component are obtained by data fitting.

  3. Matrix-exponential distributions in applied probability

    CERN Document Server

    Bladt, Mogens

    2017-01-01

    This book contains an in-depth treatment of matrix-exponential (ME) distributions and their sub-class of phase-type (PH) distributions. Loosely speaking, an ME distribution is obtained through replacing the intensity parameter in an exponential distribution by a matrix. The ME distributions can also be identified as the class of non-negative distributions with rational Laplace transforms. If the matrix has the structure of a sub-intensity matrix for a Markov jump process we obtain a PH distribution which allows for nice probabilistic interpretations facilitating the derivation of exact solutions and closed form formulas. The full potential of ME and PH unfolds in their use in stochastic modelling. Several chapters on generic applications, like renewal theory, random walks and regenerative processes, are included together with some specific examples from queueing theory and insurance risk. We emphasize our intention towards applications by including an extensive treatment on statistical methods for PH distribu...

  4. Statistical estimation for truncated exponential families

    CERN Document Server

    Akahira, Masafumi

    2017-01-01

    This book presents new findings on nonregular statistical estimation. Unlike other books on this topic, its major emphasis is on helping readers understand the meaning and implications of both regularity and irregularity through a certain family of distributions. In particular, it focuses on a truncated exponential family of distributions with a natural parameter and truncation parameter as a typical nonregular family. This focus includes the (truncated) Pareto distribution, which is widely used in various fields such as finance, physics, hydrology, geology, astronomy, and other disciplines. The family is essential in that it links both regular and nonregular distributions, as it becomes a regular exponential family if the truncation parameter is known. The emphasis is on presenting new results on the maximum likelihood estimation of a natural parameter or truncation parameter if one of them is a nuisance parameter. In order to obtain more information on the truncation, the Bayesian approach is also considere...

  5. Harmonic analysis on exponential solvable Lie groups

    CERN Document Server

    Fujiwara, Hidenori

    2015-01-01

    This book is the first one that brings together recent results on the harmonic analysis of exponential solvable Lie groups. There still are many interesting open problems, and the book contributes to the future progress of this research field. As well, various related topics are presented to motivate young researchers. The orbit method invented by Kirillov is applied to study basic problems in the analysis on exponential solvable Lie groups. This method tells us that the unitary dual of these groups is realized as the space of their coadjoint orbits. This fact is established using the Mackey theory for induced representations, and that mechanism is explained first. One of the fundamental problems in the representation theory is the irreducible decomposition of induced or restricted representations. Therefore, these decompositions are studied in detail before proceeding to various related problems: the multiplicity formula, Plancherel formulas, intertwining operators, Frobenius reciprocity, and associated alge...

  6. Perturbing Misiurewicz Parameters in the Exponential Family

    Science.gov (United States)

    Dobbs, Neil

    2015-04-01

    In one-dimensional real and complex dynamics, a map whose post-singular (or post-critical) set is bounded and uniformly repelling is often called a Misiurewicz map. In results hitherto, perturbing a Misiurewicz map is likely to give a non-hyperbolic map, as per Jakobson's Theorem for unimodal interval maps. This is despite genericity of hyperbolic parameters (at least in the interval setting). We show the contrary holds in the complex exponential family Misiurewicz maps are Lebesgue density points for hyperbolic parameters. As a by-product, we also show that Lyapunov exponents almost never exist for exponential Misiurewicz maps. The lower Lyapunov exponent is -∞ almost everywhere. The upper Lyapunov exponent is non-negative and depends on the choice of metric.

  7. Six-Parameter Exponential-Type Potential and the Identity for the Exponential-Type Potentials

    Institute of Scientific and Technical Information of China (English)

    JIA Chun-Sheng; ZENG Xiang-Lin; LI Shu-Chuan; SUN Liang-Tian; YANG Qiu-Bo

    2002-01-01

    We propose a six-parameter exponential-type potential (SPEP), which has been shown to be a shape-invariant potential with a translation of parameters. For this reducible potential, the exact energy levels are obtained byusing the supersymmetric shape invariance technique. Choosing appropriate parameters, four classes of exponential-typepotentials and their exact energy spectra are reduced from the SPEP and a general energy level formula, respectively.Each class shows the identity except for the different definitions of parameters.

  8. An exponential correction to Starobinsky's inflationary model

    CERN Document Server

    Fabris, Júlio C; Piattella, Oliver F

    2016-01-01

    We analyse $f(R)$ theories of gravity from a dynamical system perspective, showing how the $R^2$ correction in Starobinsky's model plays a crucial role from the viewpoint of the inflationary paradigm. Then, we propose a modification of Starobinsky's model by adding an exponential term in the $f(R)$ Lagrangian. We show how this modification could allow to test the robustness of the model by means of the predictions on the scalar spectral index $n_s$.

  9. Exponential Stabilization of an Underactuated Surface Vessel

    Directory of Open Access Journals (Sweden)

    Kristin Y. Pettersen

    1997-07-01

    Full Text Available The paper shows that a large class of underactuated vehicles cannot be asymptotically stabilized by either continuous or discontinuous state feedback. Furthermore, stabilization of an underactuated surface vessel is considered. Controllability properties of the surface vessels is presented, and a continuous periodic time-varying feedback law is proposed. It is shown that this feedback law exponentially stabilizes the surface vessel to the origin, and this is illustrated by simulations.

  10. Scalar field collapse with an exponential potential

    Science.gov (United States)

    Chakrabarti, Soumya

    2017-02-01

    An analogue of the Oppenheimer-Synder collapsing model is treated analytically, where the matter source is a scalar field with an exponential potential. An exact solution is derived followed by matching to a suitable exterior geometry, and an analysis of the visibility of the singularity. In some situations, the collapse indeed leads to a finite time curvature singularity, which is always hidden from the exterior by an apparent horizon.

  11. Exponential Attractor for a Nonlinear Boussinesq Equation

    Institute of Scientific and Technical Information of China (English)

    Ahmed Y. Abdallah

    2006-01-01

    This paper is devoted to prove the existence of an exponential attractor for the semiflow generated by a nonlinear Boussinesq equation. We formulate the Boussinesq equation as an abstract equation in the Hilbert space H20(0, 1) × L2(0, 1). The main step in this research is to show that there exists an absorbing set for the solution semiflow in the Hilbert space H03(0, 1) × H10(0, 1).

  12. On the ranges of discrete exponentials

    Directory of Open Access Journals (Sweden)

    Florin Caragiu

    2004-01-01

    Full Text Available Let a>1 be a fixed integer. We prove that there is no first-order formula ϕ(X in one free variable X, written in the language of rings, such that for any prime p with gcd(a,p=1 the set of all elements in the finite prime field Fp satisfying ϕ coincides with the range of the discrete exponential function t↦at(modp.

  13. Asynchronous exponential growth of a bacterial population

    Directory of Open Access Journals (Sweden)

    Mohamed Boulanouar

    2014-01-01

    Full Text Available In this work, we complete a study started earlier in [1,2] wherein a model of growing bacterial population has been the matter of a mathematical analysis. We show that the full model is governed by a strongly continuous semigroup. Beside the positivity and the irreducibility of the generated semigroup, we describe its asymptotic behavior in the uniform topology which leads to the asynchronous exponential growth of the bacterial population.

  14. Estimation and variable selection with exponential weights

    OpenAIRE

    Arias-Castro, Ery; Lounici, Karim

    2014-01-01

    In the context of a linear model with a sparse coefficient vector, exponential weights methods have been shown to be achieve oracle inequalities for denoising/prediction. We show that such methods also succeed at variable selection and estimation under the near minimum condition on the design matrix, instead of much stronger assumptions required by other methods such as the Lasso or the Dantzig Selector. The same analysis yields consistency results for Bayesian methods and BIC-type variable s...

  15. Changes in circulating blood volume after infusion of hydroxyethyl starch 6% in critically ill patients

    DEFF Research Database (Denmark)

    Christensen, P; Andersson, J; Rasmussen, S E;

    2001-01-01

    The cardiovascular response to a volume challenge with hydroxyethyl starch (HES) (200/0.5) 6% depends on the relation between the volume of HES 6% infused and the expansion of the blood volume in critically ill patients. However, only relatively limited data exist on the plasma expanding effect...... of infusion of HES 6% in critically ill patients. The purpose of the study was to evaluate the variation in the expansion of the circulating blood volume (CBV) in critically ill patients after infusion of 500 ml of colloid (HES (200/0.5) 6%) using the carbon monoxide method....

  16. Unwrapped phase inversion with an exponential damping

    KAUST Repository

    Choi, Yun Seok

    2015-07-28

    Full-waveform inversion (FWI) suffers from the phase wrapping (cycle skipping) problem when the frequency of data is not low enough. Unless we obtain a good initial velocity model, the phase wrapping problem in FWI causes a result corresponding to a local minimum, usually far away from the true solution, especially at depth. Thus, we have developed an inversion algorithm based on a space-domain unwrapped phase, and we also used exponential damping to mitigate the nonlinearity associated with the reflections. We construct the 2D phase residual map, which usually contains the wrapping discontinuities, especially if the model is complex and the frequency is high. We then unwrap the phase map and remove these cycle-based jumps. However, if the phase map has several residues, the unwrapping process becomes very complicated. We apply a strong exponential damping to the wavefield to eliminate much of the residues in the phase map, thus making the unwrapping process simple. We finally invert the unwrapped phases using the back-propagation algorithm to calculate the gradient. We progressively reduce the damping factor to obtain a high-resolution image. Numerical examples determined that the unwrapped phase inversion with a strong exponential damping generated convergent long-wavelength updates without low-frequency information. This model can be used as a good starting model for a subsequent inversion with a reduced damping, eventually leading to conventional waveform inversion.

  17. Non-exponential decay of atomic systems

    CERN Document Server

    Ishkhanyan, A M

    2014-01-01

    We discuss the possibility of non-exponential decay of various quantum quasi-stationary systems. This effect can occur at the times which are greater than the lifetime of a considered system. The mechanism for non-exponential depletion of an initial quasi-stationary state is the cutting of the energy spectrum of final continuous states at long times. We first consider the known examples of cold emission of electrons from metal, tunneling alpha-decay of atomic nuclei, and spontaneous decay in two-level systems. The new physical situations discussed are the single-photon atomic ionization by a weak electromagnetic field and tunneling ionization of atoms by a strong low-frequency electromagnetic field. In both cases the decay obeys a power-law dependence on the (long) interaction time. We find that the most promising possibility for observing non-exponential decay at long times is the single-photon ionization of negative atomic ions near the threshold.

  18. [Soft tissues volumes changing in malar and cheek area after fat grafting].

    Science.gov (United States)

    Nadtochiy, A G; Grischenko, S V; Malitskaya, O A

    2016-01-01

    To improve the predictability of facial soft tissues fat grafting results tissue thickness dynamics before and 1 year postoperatively was assessed by means of ultrasonic method in 58 patients under standardized position of the ultrasonic transducer, physical and technical scanning conditions. The study revealed direct correlation of soft tissues thickness increase after fat grafting with the initial thickness of recipient area tissues. One year after fat grafting 60-65% of additional thickness remained in the lower regions of malar-cheek area (with the greatest soft tissues thickness), and only 25-27% preserved in the upper regions with the minimal initial thickness of soft tissues. I.e. to achieve necessary correction volume in a zone with small initial soft tissues thickness it is necessary to increase the amount of fat grafting stages. As the rates of soft tissues thickness in correction area change during 3-4 months after fat grafting remaining stable after this period it is expedient to assess postoperative results and to carry out repeated fat grafting not earlier than 4 months after operation.

  19. Bioassays with unicellular algae: deviations from exponential growth and its implications for toxicity test results.

    Science.gov (United States)

    Altenburger, Rolf; Schmitt-Jansen, Mechthild; Riedl, Janet

    2008-01-01

    Growth assays with unicellular green algae are an established tool in ecotoxicological effect assessment for chemicals and environmental samples. From an ecological perspective it seems appropriate to use the growth rate as a process variable rather than a measure of biomass gain for calculating inhibitory effects of contaminants. The notion of simple exponential growth for the description of the population increase in undisturbed suspension cultures of unicellular green algae, however, seems to be an oversimplification. Experimental findings describe the increase in biomass, cell number, the development of cell volume distributions of populations, and the relationship between cell size and chlorophyll content for individual cells over one generation at a time resolution of 2-h intervals. It was observed that algal populations of Desmodesmus subspicatus show a time pattern of cell size growth; the average cell volume increases about sixfold, without corresponding increase in population size. This is followed by a distinct cell division phase with little gain in biomass. This synchronous growth behavior despite continuous illumination may be explained by the multiple fission characteristic of unicellular green algae which is an adaptation to cyclic light-dark changes in the environment. It might be controlled by an independent cell cycle clock. For routine regulatory testing fluorescence-based measurements rather than cell counting minimizes the confounding effect on toxicity determination. For investigations of time-dependent effects, e.g., by pulsed exposure, an alternative mechanistically based growth function for unicellular algae is proposed that accommodates for the observed growth pattern.

  20. Ultrasound as a Noninvasive Method to Assess Changes of Intracranial Volume and Pressure During Simulated Microgravity

    Science.gov (United States)

    Murthy, G.; Yost, W. T.; Ballard, R. E.; Watenpaugh, D. E.; Kawai, Y.; Hargens, A. R.

    1994-01-01

    Headaches are commonly experienced by astronauts in microgravity and by subjects undergoing head-down tilt (simulated microgravity on Earth). Exposure to microgravity probably elevates blood pressure and flow in the head which may increase intracranial volume (ICV) and pressure (ICP) and in turn cause headache. Due to the slightly compliant nature of the cranial vault and the encasement of brain and its vasculature within this vault, any increase of ICV will increase ICP and slightly distend the cranium. Previous studies document perivascular edema and increased ICP in rhesus monkeys during head-down tilt. Elevated ICP has also been reported in humans during head-down tilt. ICP measurements in healthy humans are rare because of the invasiveness of currently-available measurement techniques. Therefore, we proposed a noninvasive ultrasound technique to assess changes of ICV and JCP. The ultrasound principle is based on compliance of the cranial vault. A 450 kHz ultrasound stimulus is transmitted through the cranium by a transducer every 7.5-10 msec. The ultrasound wave enters the brain tissue, reflects off the opposite side of the cranium and is received by the same transducer. The detected wave is compared for phase quadrature (90 deg.to transmitted wave). Because the electronic circuitry of the device maintains a 90 deg. phase (phi), any alterations in the detected wave caused by an increase of ICV and ICP will be reflected as a change in the wave frequency. Phase shift is directly proportional to path length of the wave, DELTA x, which is expressed as DELTA x = phi lambda/2 pi where lambda is wavelength. Elevated ICV and ICP expand the cranial vault and increase path length of the wave (a measure of intracranial distance). Increased path length equals reduced frequency of the detected wave. Reduced frequency is then related to elevated ICP. This technique has potential uses for ICP studies of astronauts in space and head trauma patients on Earth.

  1. Investigations into the free-volume changes within starch/plasticizer/nanoclay systems using Positron Annihilation Lifetime Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Huihua, E-mail: h.liu@federation.edu.au [School of Health Sciences, Federation University Australia, Ballarat, Vic (Australia); Chaudhary, Deeptangshu, E-mail: deepc@ers.com.au [ERS Environmental Risk Solutions PTY LTD, Perth, WA (Australia); Campbell, Colin, E-mail: colin.campbell@anu.edu.au [ARC Centre of Excellence for Antimatter-Matter Studies (CAMS), Research School of Physics and Engineering, Australian National University, Canberra (Australia); Roberts, Jason, E-mail: jxr107@physics.anu.edu.au [ARC Centre of Excellence for Antimatter-Matter Studies (CAMS), Research School of Physics and Engineering, Australian National University, Canberra (Australia); Buckman, Stephen, E-mail: stephen.buckman@anu.edu.au [ARC Centre of Excellence for Antimatter-Matter Studies (CAMS), Research School of Physics and Engineering, Australian National University, Canberra (Australia); Sullivan, James, E-mail: james.sullivan@anu.edu.au [ARC Centre of Excellence for Antimatter-Matter Studies (CAMS), Research School of Physics and Engineering, Australian National University, Canberra (Australia)

    2014-11-14

    The free-volume of a matrix is a fundamental parameter that relates to its molecular and bulk characteristics, such as crystalline change and glass transition behavior. In starch-based bionanocomposite, we investigated the effect of the addition of montmorillonite nanoclay (MMT) and food plasticizers (glycerol and sorbitol) on changes of molecular pore size (including pore volume and pore distribution) using the Positron Annihilation Lifetime Spectroscopy (PALS) method. The results demonstrated counter-intuitive impact of MMT on the total free-volume where the total free-volume increased within the polymeric matrix. When compared to the pure matrix free-volume, the addition of MMT also resulted in the appearance of a broader distribution of the void sizes. The plasticizers, on the other hand, apparently occupied the void spaces, and therefore decreased the free-volume of the matrix. Further, together with the small angle X-ray scattering (SAXS) analysis, we concluded that this is a result of interplay between the plasticizer-plasticizer interactions and the polymer–plasticizer interactions. For example, in the starch/glycerol/MMT system, the pore radii slightly decrease upon the increasing of glycerol amount (OG210 = O.27 nm and OG220 = 0.26 nm), but the relative weight did increase with the increasing glycerol concentration. However, increasing the sorbitol amount increased the pore size from 0.23 nm(OS210) to 0.28 nm(OS220). Furthermore, the addition MMT in the OS010 system, promote the emergence of a new dateable pore radius(0.90 nm), and the total weight significantly increased from 13.70 (OS010) to 19.5% (OS210). We suggest that the pore variation (size and distribution) due to the MMT and plasticizers are reflected in the polymer glass transition and crystallinity because ultimately, the, total free-volume is a reflection of level of interactions existing within the bulk of these nanocomposites. - Highlights: • PALS is applied to explore the

  2. Reverse asymmetry and changes in brain structural volume of the basal ganglia in ADHD, developmental changes and the impact of stimulant medications.

    Science.gov (United States)

    Paclt, Ivo; Pribilová, Nikol; Kollárová, Patricie; Kohoutová, Milada; Dezortová, Monika; Hájek, Milan; Csemy, Ladislav

    2016-01-01

    We discussed the cross section studies and the meta-analysis of published data in children and adolescents with ADHD (both drug naive and receiving stimulant medications), in comparison with healthy children and adolescents of the same age. In children and adolescents with ADHD the deceleration of the maturation dynamics of discrete CNS structures is found, volume reduction and decreased grey matter in prefrontal and occipital regions, which is accompanied by reverse asymmetry of the basal ganglia volume (putamen, nucleus caudate). The above mentioned developmental characteristics are valid only for the ADHD children, who have not been treated by stimulant medications. The stimulant treatment eliminates the mentioned changes into various extend. These developmental changes of CNS structures volume are missing in girls.

  3. Age dependent white matter lesions and brain volume changes in healthy volunteers

    DEFF Research Database (Denmark)

    Christiansen, P; Larsson, H B; Thomsen, C

    1994-01-01

    The brain of 142 healthy volunteers aged 21 to 80 years were investigated using MR imaging. The number and size of the white matter hyperintensity lesions (WMHL) in the cerebral hemispheres were determined. Furthermore, the volume of the cerebral hemispheres and of the lateral ventricles...... was measured. An almost linear increase in the number of volunteers with WMHL was seen with aging for males and females. With aging a significant decrease in the volume of the cerebral hemispheres was found for males, and a significant increase in the volume of the lateral ventricles was seen for both males...... and females. Our results suggest that with aging central atrophy increases more (relatively) than cortical atrophy. No correlation was found between the decreasing volume of the cerebral hemispheres and the increasing number and size of WMHL, nor between the increasing volume of the lateral ventricles...

  4. Change Matters: Critical Essays on Moving Social Justice Research from Theory to Policy. Critical Qualitative Research. Volume 1

    Science.gov (United States)

    Miller, S. J., Ed.; Kirkland, David E., Ed.

    2010-01-01

    "Change Matters," written by leading scholars committed to social justice in English education, provides researchers, university instructors, and preservice and inservice teachers with a framework that pivots social justice toward policy. The chapters in this volume detail rationales about generating social justice theory in what Freire calls "the…

  5. Assessment and forecast of changes of reservoir volumes due to thermal settling in permafrost areas of Russia

    Institute of Scientific and Technical Information of China (English)

    Ilja S.Sobol; Stanislav V.Sobol

    2014-01-01

    This paper presents the results of data analyses and assessments of field and theoretical researches on reservoir bed relief transformation due to thermal settling in the permafrost regions of Russia. The resulting changes (increases) of the total volumes of large and small reservoirs are quantified, of which information will be of great use in future reservoir design and exploitation.

  6. Morphometric brain characterization of refractory obsessive-compulsive disorder: diffeomorphic anatomic registration using exponentiated Lie algebra.

    Science.gov (United States)

    Tang, Wanjie; Li, Bin; Huang, Xiaoqi; Jiang, Xiaoyu; Li, Fei; Wang, Lijuan; Chen, Taolin; Wang, Jinhui; Gong, Qiyong; Yang, Yanchun

    2013-10-01

    Few studies have used neuroimaging to characterize treatment-refractory obsessive-compulsive disorder (OCD). This study sought to explore gray matter structure in patients with treatment-refractory OCD and compare it with that of healthy controls. A total of 18 subjects with treatment-refractory OCD and 26 healthy volunteers were analyzed by MRI using a 3.0-T scanner and voxel-based morphometry (VBM). Diffeomorphic anatomical registration using exponentiated Lie algebra (DARTEL) was used to identify structural changes in gray matter associated with treatment-refractory OCD. A partial correlation model was used to analyze whether morphometric changes were associated with Yale-Brown Obsessive-Compulsive Scale scores and illness duration. Gray matter volume did not differ significantly between the two groups. Treatment-refractory OCD patients showed significantly lower gray matter density than healthy subjects in the left posterior cingulate cortex (PCC) and mediodorsal thalamus (MD) and significantly higher gray matter density in the left dorsal striatum (putamen). These changes did not correlate with symptom severity or illness duration. Our findings provide new evidence of deficits in gray matter density in treatment-refractory OCD patients. These patients may show characteristic density abnormalities in the left PCC, MD and dorsal striatum (putamen), which should be verified in longitudinal studies. © 2013. Published by Elsevier Inc. All rights reserved.

  7. Heat transfer analysis of water-based nanofluid over an exponentially stretching sheet

    Directory of Open Access Journals (Sweden)

    Sohail Nadeem

    2014-03-01

    Full Text Available The aim of the present study is to analyze the flow of three-dimensional water-based nanofluid over an exponentially stretching sheet. The transport equations are transformed into nonlinear, coupled similarity equations using three-dimensional exponential type similarity transformations. These equations are solved numerically to obtain the velocities and temperature in the respective boundary layers. Results are presented to illustrate the effects of various parameters including the temperature exponent, stretching parameter and volume fraction of three different types of nanoparticles, such as copper (Cu, alumina (Al2O3 and titanium dioxide (TiO2 with water as a base fluid.

  8. Rotating flow of a nanofluid due to an exponentially stretching surface with suction

    Science.gov (United States)

    Salleh, Siti Nur Alwani; Bachok, Norfifah; Arifin, Norihan Md

    2017-08-01

    An analysis of the rotating nanofluid flow past an exponentially stretched surface with the presence of suction is studied in this work. Three different types of nanoparticles, namely, copper, titania and alumina are considered. The system of ordinary differential equations is computed numerically using a shooting method in Maple software after being transformed from the partial differential equations. This transformation has considered the similarity transformations in exponential form. The physical effect of the rotation, suction and nanoparticle volume fraction parameters on the rotating flow and heat transfer phenomena is investigated and has been described in detail through graphs. The dual solutions are found to appear when the governing parameters reach a certain range.

  9. Longitudinal volume changes of the pituitary gland in patients with schizotypal disorder and first-episode schizophrenia.

    Science.gov (United States)

    Takahashi, Tsutomu; Zhou, Shi-Yu; Nakamura, Kazue; Tanino, Ryoichiro; Furuichi, Atsushi; Kido, Mikio; Kawasaki, Yasuhiro; Noguchi, Kyo; Seto, Hikaru; Kurachi, Masayoshi; Suzuki, Michio

    2011-01-15

    An enlarged volume of the pituitary gland has been reported in the schizophrenia spectrum, possibly reflecting the hypothalamic-pituitary-adrenal (HPA) hyperactivity. However, it remains largely unknown whether the pituitary size longitudinally changes in the course of the spectrum disorders. In the present study, longitudinal magnetic resonance imaging (MRI) data were obtained from 18 patients with first-episode schizophrenia, 13 patients with schizotypal disorder, and 20 healthy controls. The pituitary volume was measured at baseline and follow-up (mean, 2.7 years) scans and was compared across groups. The pituitary volume was larger in the schizophrenia patients than controls at baseline, and both patient groups had significantly larger pituitary volume than controls at follow-up. In a longitudinal comparison, both schizophrenia (3.6%/year) and schizotypal (2.7%/year) patients showed significant pituitary enlargement compared with controls (-1.8%/year). In the schizophrenia patients, greater pituitary enlargement over time was associated with less improvement of delusions and higher scores for thought disorders at the follow-up. These findings suggest that the pituitary gland exhibits ongoing volume changes during the early course of the schizophrenia spectrum as a possible marker of state-related impairments. Copyright © 2010 Elsevier Inc. All rights reserved.

  10. Digital surgical templates for managing high-energy zygomaticomaxillary complex injuries associated with orbital volume change: a quantitative assessment.

    Science.gov (United States)

    Liu, Xiang-Zhen; Shu, Da-Long; Ran, Wei; Guo, Bing; Liao, Xin

    2013-10-01

    This study sought to introduce 3-dimensional (3D) virtual surgical planning and digital rapid-prototyping templates for zygomaticomaxillary complex (ZMC) injuries associated with orbital volume change and to evaluate the surgical outcomes quantitatively. Eight patients who underwent open reduction and fixation for a ZMC injury with orbital volume change were studied. Computed tomographic (CT) scan of the zygomaticomaxillary area was performed before the operation in each case. Scanned data were converted into 3D models using Mimics software (Materialise, Brussels, Belgium) for surgical designs. Virtual surgical reductions and correlated guiding templates were designed using Mimics and Magics software (Materialise). The operations were performed with the help of prefabricated templates to reduce the fractures. A postoperative CT scan of each patient was obtained within 2 weeks after surgery, and quantitative measurements were made to assess the surgical outcomes. Preoperative volumes of the bilateral orbits were compared, and concordance with postoperative volumes of the bilateral orbits was assessed. Twenty-one pairs of distances from 7 marker points to 3 reference planes were measured to assess postoperative facial symmetry. Volumes of the injured orbits were significantly different from volumes of the uninjured orbits preoperatively (P .05). In addition, 19 of the 21 pairs of bilateral distances showed no significant difference postoperatively (P > .05). Quantitative assessment showed that digitally designed, rapid-prototyping templates for ZMC fractures have a positive impact on restoring facial symmetry and concordance of bilateral orbital volumes. Copyright © 2013 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  11. A pomegranate-inspired nanoscale design for large-volume-change lithium battery anodes

    Science.gov (United States)

    Liu, Nian; Lu, Zhenda; Zhao, Jie; McDowell, Matthew T.; Lee, Hyun-Wook; Zhao, Wenting; Cui, Yi

    2014-03-01

    Silicon is an attractive material for anodes in energy storage devices, because it has ten times the theoretical capacity of its state-of-the-art carbonaceous counterpart. Silicon anodes can be used both in traditional lithium-ion batteries and in more recent Li-O2 and Li-S batteries as a replacement for the dendrite-forming lithium metal anodes. The main challenges associated with silicon anodes are structural degradation and instability of the solid-electrolyte interphase caused by the large volume change (~300%) during cycling, the occurrence of side reactions with the electrolyte, and the low volumetric capacity when the material size is reduced to a nanometre scale. Here, we propose a hierarchical structured silicon anode that tackles all three of these problems. Our design is inspired by the structure of a pomegranate, where single silicon nanoparticles are encapsulated by a conductive carbon layer that leaves enough room for expansion and contraction following lithiation and delithiation. An ensemble of these hybrid nanoparticles is then encapsulated by a thicker carbon layer in micrometre-size pouches to act as an electrolyte barrier. As a result of this hierarchical arrangement, the solid-electrolyte interphase remains stable and spatially confined, resulting in superior cyclability (97% capacity retention after 1,000 cycles). In addition, the microstructures lower the electrode-electrolyte contact area, resulting in high Coulombic efficiency (99.87%) and volumetric capacity (1,270 mAh cm-3), and the cycling remains stable even when the areal capacity is increased to the level of commercial lithium-ion batteries (3.7 mAh cm-2).

  12. Thermal Volume Changes and Creep in the Callovo-Oxfordian Claystone

    Science.gov (United States)

    Belmokhtar, Malik; Delage, Pierre; Ghabezloo, Siavash; Conil, Nathalie

    2017-09-01

    The Callovo-Oxfordian (COx) claystone is considered as a potential host rock for high-level radioactive waste disposal at great depth in France. Given the exothermic nature of radioactive wastes, a temperature elevation planned to be smaller than 100 °C will affect the host rock around the disposal cells. To gain better understanding of the thermal volumetric response of the COx claystone, a new thermal isotropic compression cell was developed with particular attention devoted to monitoring axial and radial strains. To do so, a high-precision LVDTs system ensuring direct contact between the LVDT stem and the claystone sample through the membrane was developed. A short drainage length (10 mm) was also ensured so as to allow full saturation of the sample under stress conditions close to in situ, and fully drained conditions during compression. High-precision strain monitoring allowed to observe a volumetric creep under stress conditions close to in situ. A drained heating test under constant stress carried out afterwards up to 80 °C exhibited a thermoelastic expansion up to a temperature of 48 °C, followed by thermoplastic contraction at higher temperature. Creep volume changes, that appeared to be enhanced by temperature, were modelled by using a simple Kelvin-Voigt model, so as to estimate the instantaneous response of the COx claystone and to determine its thermal expansion coefficient. The temperature at which the transition between thermal expansion and contraction appeared is close to the maximum burial temperature of the Callovo-Oxfordian claystone, estimated at 50 °C. This is in agreement with what has been already observed on the Opalinus Clay by Monfared et al. (2012) that was interpreted as a thermal hardening phenomenon, showing that the material kept the memory of the highest temperature supported during its geological history.

  13. Exponential smoothing for financial time series data forecasting

    Directory of Open Access Journals (Sweden)

    Kuzhda, Tetyana Ivanivna

    2014-05-01

    Full Text Available The article begins with the formulation for predictive learning called exponential smoothing forecasting. The exponential smoothing is commonly applied to financial markets such as stock or bond, foreign exchange, insurance, credit, primary and secondary markets. The exponential smoothing models are useful in providing the valuable decision information for investors. Simple and double exponential smoothing models are two basic types of exponential smoothing method. The simple exponential smoothing method is suitable for financial time series forecasting for the specified time period. The simple exponential smoothing weights past observations with exponentially decreasing weights to forecast future values. The double exponential smoothing is a refinement of the simple exponential smoothing model but adds another component which takes into account any trend in the data. The double exponential smoothing is designed to address this type of data series by taking into account any trend in the data. Measurement of the forecast accuracy is described in this article. Finally, the quantitative value of the price per common share forecast using simple exponential smoothing is calculated. The applied recommendations concerning determination of the price per common share forecast using double exponential smoothing are shown in the article.

  14. Assessment of bronchodilator response through changes in lung volumes in chronic airflow obstruction

    Directory of Open Access Journals (Sweden)

    J.B. Figueroa-Casas

    2003-10-01

    Full Text Available Although FEV1 improvement is routinely used to define bronchodilator (BD response, it correlates poorly with clinical effects. Changes in lung volumes (LV have shown better correlation with exercise tolerance and might be more sensitive to detect BD effects. We assessed the additional contribution of measuring LV before and after BD to detect acute improvement in lung function not demonstrated by FEV1, and the influence of the response criteria selected on this contribution. We analyzed 98 spirometries and plethismographies performed pre and post BD in patients with airflow obstruction (FEV1/FVC 10% of baseline (D>5 anD>15% were also analyzed. FEV1 identified as responders 32% of patients. Greater proportions were uncovered by slow vital capacity (51%, p5 anD>15%. Mean change and proportions of responders for each LV varied significantly (pSi bien el aumento del VEF1 es habitualmente utilizado para definir respuesta a broncodilatadores (BD, su correlación con efectos clínicos es pobre. Los cambios en volúmenes pulmonares (VP han demostrado mejor correlación con tolerancia al ejercicio y podrían ser más sensibles para detectar efectos de los BD. Nosotros evaluamos la contribución adicional de medir VP antes y después de BD para detectar mejoría funcional aguda no demostrada por cambios del VEF1, y la influencia del criterio de respuesta seleccionado en esta contribución. Se analizaron 98 espirometrías y pletismografías realizadas pre y post BD en pacientes con obstrucción al flujo aéreo (VEF1/CVF 10% del basal (D>5 y 15% fueron también analizados. El VEF1 identificó como respondedores a 32% de los pacientes. Proporciones mayores fueron identificadas por capacidad vital lenta (51%, p5 y 15%. El cambio promedio y las proporciones de respondedores para cada VP variaron significativamente (p<0.05 según que el cambio fuese expresado como porcentaje del basal o del valor predicho. Una proporción considerable de pacientes con obstrucci

  15. Exponential Stability Criteria for Nonautonomous Difference Systems

    Directory of Open Access Journals (Sweden)

    Rigoberto Medina

    2014-01-01

    Full Text Available The aim of this paper is to characterize the exponential stability of linear systems of difference equations with slowly varying coefficients. Our approach is based on the generalization of the freezing method for difference equations combined with new estimates for the norm of bounded linear operators. The main novelty of this work is that we use estimates for the absolute values of entries of a matrix-valued function, instead of bounds on its eigenvalues. By this method, new explicit stability criteria for linear nonautonomous systems are derived.

  16. Exponential sums over primes in short intervals

    Institute of Scientific and Technical Information of China (English)

    LIU Jianya; L(U) Guangshi; ZHAN Tao

    2006-01-01

    In this paper we establish one new estimate on exponential sums over primes in short intervals. As an application of this result, we sharpen Hua's result by proving that each sufficiently large integer N congruent to 5 modulo 24 can be written as N = p21 +p22 +p23 +p24 +p25, with |pj - √N/5| ≤ U = N1/2-1/20+ε,where pj are primes. This result is as good as what one can obtain from the generalized Riemann hypothesis.

  17. Finite difference computing with exponential decay models

    CERN Document Server

    Langtangen, Hans Petter

    2016-01-01

    This text provides a very simple, initial introduction to the complete scientific computing pipeline: models, discretization, algorithms, programming, verification, and visualization. The pedagogical strategy is to use one case study – an ordinary differential equation describing exponential decay processes – to illustrate fundamental concepts in mathematics and computer science. The book is easy to read and only requires a command of one-variable calculus and some very basic knowledge about computer programming. Contrary to similar texts on numerical methods and programming, this text has a much stronger focus on implementation and teaches testing and software engineering in particular. .

  18. Two Interesting Properties of the Exponential Distribution

    OpenAIRE

    Chen, Robert W.

    2015-01-01

    Let $X_1, X_2,\\ldots, X_n$ be $n$ independent and identically distributed random variables, here $n \\geq 2.$ Let $X_{(1)}, X_{(2)}, \\ldots, X_{(n)}$ be the order statistics of $X_1, X_2,..., X_n.$ In this note we proved that: (I) If $X_1, X_2,..., X_n$ are exponential random variables with parameter $c > 0,$ then the "correlation coefficient" between $X_{(k)}$ and $X_{(k+t)}$ is strictly increasing in $k$ from $1$ to $m,$ and then is strictly decreasing in $k$ from $m$ to $n - t,$ here $t$ is...

  19. Progressive Exponential Clustering-Based Steganography

    Directory of Open Access Journals (Sweden)

    Li Yue

    2010-01-01

    Full Text Available Cluster indexing-based steganography is an important branch of data-hiding techniques. Such schemes normally achieve good balance between high embedding capacity and low embedding distortion. However, most cluster indexing-based steganographic schemes utilise less efficient clustering algorithms for embedding data, which causes redundancy and leaves room for increasing the embedding capacity further. In this paper, a new clustering algorithm, called progressive exponential clustering (PEC, is applied to increase the embedding capacity by avoiding redundancy. Meanwhile, a cluster expansion algorithm is also developed in order to further increase the capacity without sacrificing imperceptibility.

  20. Exponentially Convergent Algorithms for Abstract Differential Equations

    CERN Document Server

    Gavrilyuk, Ivan; Vasylyk, Vitalii

    2011-01-01

    This book presents new accurate and efficient exponentially convergent methods for abstract differential equations with unbounded operator coefficients in Banach space. These methods are highly relevant for the practical scientific computing since the equations under consideration can be seen as the meta-models of systems of ordinary differential equations (ODE) as well as the partial differential equations (PDEs) describing various applied problems. The framework of functional analysis allows one to obtain very general but at the same time transparent algorithms and mathematical results which

  1. Information and exponential families in statistical theory

    CERN Document Server

    Barndorff-Nielsen, O

    2014-01-01

    First published by Wiley in 1978, this book is being re-issued with a new Preface by the author. The roots of the book lie in the writings of RA Fisher both as concerns results and the general stance to statistical science, and this stance was the determining factor in the author's selection of topics. His treatise brings together results on aspects of statistical information, notably concerning likelihood functions, plausibility functions, ancillarity, and sufficiency, and on exponential families of probability distributions. 

  2. Compact vs. Exponential-Size LP Relaxations

    Energy Technology Data Exchange (ETDEWEB)

    Carr, R.D.; Lancia, G.

    2000-09-01

    In this paper we introduce by means of examples a new technique for formulating compact (i.e. polynomial-size) LP relaxations in place of exponential-size models requiring separation algorithms. In the same vein as a celebrated theorem by Groetschel, Lovasz and Schrijver, we state the equivalence of compact separation and compact optimization. Among the examples used to illustrate our technique, we introduce a new formulation for the Traveling Salesman Problem, whose relaxation we show equivalent to the subtour elimination relaxation.

  3. Exponential algorithmic speedup by quantum walk

    CERN Document Server

    Childs, A M; Deotto, E; Farhi, E; Gutmann, S; Spielman, D A; Childs, Andrew M.; Cleve, Richard; Deotto, Enrico; Farhi, Edward; Gutmann, Sam; Spielman, Daniel A.

    2002-01-01

    We construct an oracular problem that can be solved exponentially faster on a quantum computer than on a classical computer. The quantum algorithm is based on a continuous time quantum walk, and thus employs a different technique from previous quantum algorithms based on quantum Fourier transforms. We show how to implement the quantum walk efficiently in our oracular setting. We then show how this quantum walk can be used to solve our problem by rapidly traversing a graph. Finally, we prove that no classical algorithm can solve this problem with high probability in subexponential time.

  4. Evaluation of postoperative change in lung volume in adolescent idiopathic scoliosis: Measured by computed tomography

    Directory of Open Access Journals (Sweden)

    Dong Kyu Lee

    2014-01-01

    Conclusion: Patients with AIS who have preoperative reduced lung volumes or lung functions can achieve further increased lung volume after surgical correction. Pulmonary complications during perioperative period were mostly treated with proper management without severe sequale. Therefore, although surgery for AIS is considered to be a high risk procedure, we can recommend to correct spine deformity in patients with severe AIS in order to improve lung function and long term prognosis.

  5. Modulation of cadmium-induced mitochondrial dysfunction and volume changes by temperature in rainbow trout (Oncorhynchus mykiss)

    Energy Technology Data Exchange (ETDEWEB)

    Onukwufor, John O. [Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada C1A 4P3 (Canada); Kibenge, Fred [Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada C1A 4P3 (Canada); Stevens, Don [Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada C1A 4P3 (Canada); Kamunde, Collins, E-mail: ckamunde@upei.ca [Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada C1A 4P3 (Canada)

    2015-01-15

    Highlights: • Interactions of Cd and temperature exacerbate mitochondrial dysfunction and enhance Cd accumulation. • Cd uptake by mitochondria occurs through the Ca uniporter. • Temperature exacerbates Cd-induced mitochondrial volume changes. • Low concentrations of Cd inhibit mitochondrial swelling. - Abstract: We investigated how temperature modulates cadmium (Cd)-induced mitochondrial bioenergetic disturbances, metal accumulation and volume changes in rainbow trout (Oncorhynchus mykiss). In the first set of experiments, rainbow trout liver mitochondrial function and Cd content were measured in the presence of complex I substrates, malate and glutamate, following exposure to Cd (0–100 μM) at three (5, 13 and 25 °C) temperatures. The second set of experiments assessed the effect of temperature on Cd-induced mitochondrial volume changes, including the underlying mechanisms, at 15 and 25 °C. Although temperature stimulated both state 3 and 4 rates of respiration, the coupling efficiency was reduced at temperature extremes due to greater inhibition of state 3 at low temperature and greater stimulation of state 4 at the high temperature. Cadmium exposure reduced the stimulatory effect of temperature on state 3 respiration but increased that on state 4, consequently exacerbating mitochondrial uncoupling. The interaction of Cd and temperature yielded different responses on thermal sensitivity of state 3 and 4 respiration; the Q{sub 10} values for state 3 respiration increased at low temperature (5–13 °C) while those for state 4 increased at high temperature (13–25 °C). Importantly, the mitochondria accumulated more Cd at high temperature suggesting that the observed greater impairment of oxidative phosphorylation with temperature was due, at least in part, to a higher metal burden. Cadmium-induced mitochondrial volume changes were characterized by an early phase of contraction followed by swelling, with temperature changing the kinetics and

  6. Change in Tear Film Lipid Layer Thickness, Corneal Thickness, Volume and Topography after Superficial Cauterization for Conjunctivochalasis.

    Science.gov (United States)

    Chan, Tommy C Y; Ye, Cong; Ng, Paul K F; Li, Emmy Y M; Yuen, Hunter K L; Jhanji, Vishal

    2015-07-17

    We evaluated the change in tear film lipid layer thickness, corneal thickness, volume and topography after superficial cauterization of symptomatic conjunctivochalasis. Bilateral superficial conjunctival cauterization was performed in 36 eyes of 18 patients with symptomatic conjunctivochalasis. The mean age of patients (12 males, 6 females) was 68.6 ± 10.9 years (range: 44-83 years). Preoperatively, 28 eyes (77.8%) had grade 1 conjunctivochalasis, and 8 eyes (22.2%) had grade 2 conjunctivochalasis. At 1 month postoperatively, the severity of conjunctivochalasis decreased significantly (p corneal thickness, thinnest corneal thickness and corneal volume decreased significantly postoperatively (p corneal thickness and volume were observed after surgical correction of conjunctivochalasis.

  7. Rounded stretched exponential for time relaxation functions.

    Science.gov (United States)

    Powles, J G; Heyes, D M; Rickayzen, G; Evans, W A B

    2009-12-01

    A rounded stretched exponential function is introduced, C(t)=exp{(tau(0)/tau(E))(beta)[1-(1+(t/tau(0))(2))(beta/2)]}, where t is time, and tau(0) and tau(E) are two relaxation times. This expression can be used to represent the relaxation function of many real dynamical processes, as at long times, t>tau(0), the function converges to a stretched exponential with normalizing relaxation time, tau(E), yet its expansion is even or symmetric in time, which is a statistical mechanical requirement. This expression fits well the shear stress relaxation function for model soft soft-sphere fluids near coexistence, with tau(E)Cole-Cole plots for dielectric and shear stress relaxation (both the modulus and viscosity forms). It is shown that both the dielectric spectra and dynamic shear modulus imaginary parts approach the real axis with a slope equal to 0 at high frequency, whereas the dynamic viscosity has an infinite slope in the same limit. This indicates that inertial effects at high frequency are best discerned in the modulus rather than the viscosity Cole-Cole plot. As a consequence of the even expansion in time of the shear stress relaxation function, the value of the storage modulus derived from it at very high frequency exceeds that in the infinite frequency limit (i.e., G(infinity)).

  8. Reviving Quintessence with an Exponential Potential

    CERN Document Server

    Chang, Hui-Yiing

    2016-01-01

    We examine a quintessence model with a modified exponential potential given by $V(\\phi) = V_0(1+e^{-\\lambda \\phi})$. Unlike quintessence with a standard exponential potential, our model can yield an acceptable accelerated expansion at late times, while producing a distinct "early dark energy" signature at high redshift. We determine the evolution of the equation of state parameter, $w_\\phi$, and the density parameter, $\\Omega_\\phi$, as a function of the scale factor. The strongest constraints on the model come from cosmic microwave background observations rather than supernova data. The former give the limit $\\lambda > 13$. This model predicts a value of the effective neutrino number during Big Bang nucleosynthesis larger than the standard model value. It also provides a partial solution to the coincidence problem, in that the ratio of the quintessence energy density is always within a few orders of magnitude of the background radiation or matter density from the early universe up to the present, but it does ...

  9. Clinical study on the changes of the tumor target volume and organs at risk in helical tomotherapy for nasopharyngeal carcinoma

    Institute of Scientific and Technical Information of China (English)

    LU Na; FENG Lin-chun; CAI Bo-ning; HOU Jun; WANG Yun-lai; XIE Chuan-bin

    2012-01-01

    Background Helical tomotherapy (HT) is a new image-guided intensity-modulated radiation therapy (IMRT).The aim of this study was to evaluate the changes in the target volume and organs at risk (OARs) of patients with nasopharyngeal carcinoma (NPC) during helical tomotherapy.Methods Forty-three patients with NPC and treated via HT from March 2008 to January 2010 were reviewed retrospectively.Repeated CT scanning and plan adaptation were conducted at the 20th fraction during radiotherapy.The volumetric differences between the two scans were evaluated for nasopharyngeal tumor and retro- pharyngeal lymph nodes (GTVnx),neck lymph nodes (GTVnd),and parotid glands,as well as the axial diameter of the head.Results The median interval between the two scans was 25 days (23-28 days).The volumetric decrease in GTVnx was 30.1% (median,29.8%) and in GTVnd 41.6% (median,45.9%).The variation in the GTVnd volume was correlated with the weight loss of the patient.The volume of the left parotid gland decreased by 35.5% (median,33.4%) and of the right parotid glands decreased by 36.8% (median,33.5%).The axial diameter of the head decreased by 9.39% (median,9.1%).Conclusions The target volume and OARs of patients with NPC varied considerably during HT.These changes may have potential dosimetric effects on the target volume and/or OARs and influence the clinical outcome.Repeated CT scanning and replanning during the HT for NPC patients with a large target volume or an obvious weight loss are recommended.

  10. On the single-exponential closed form of the product of two exponential operators

    Energy Technology Data Exchange (ETDEWEB)

    Tudor, Tiberiu [Faculty of Physics, University of Bucharest, PO Box MG-11, 0771253 Bucharest-Magurele (Romania)

    2007-12-07

    In the frame of a vectorial Pauli algebraic approach it is shown that the product of two exponentials of any two-by-two linear operators can be put in a single-exponential closed form. As a first application, a compact vectorial expression for the characteristics (angle and axis) of the product of two R{sup 3} rotations is established. The same mathematics can be used in a large diversity of problems of the whole class of two-states physical systems. An exemplification in the field of polarization optics is given.

  11. Exponential and double exponential tails for maximum of two-dimensional discrete Gaussian free field

    CERN Document Server

    Ding, Jian

    2011-01-01

    We study the tail behavior for the maximum of discrete Gaussian free field on a 2D box with Dirichlet boundary condition after centering by its expectation. We show that it exhibits an exponential decay for the right tail and a double exponential decay for the left tail. In particular, our result implies that the variance of the maximum is of order 1, improving an $o(\\log n)$ bound by Chatterjee (2008) and confirming a folklore conjecture. An important ingredient for our proof is a result of Bramson and Zeitouni (2010), who proved the tightness of the centered maximum together with an evaluation of the expectation up to an additive constant.

  12. Measurements of Enthalpy Change of Reaction of Formation, Molar Heat Capacity and Constant-Volume Combustion Energy of Solid Complex Yb(Et2dtc)3(phen)

    Institute of Scientific and Technical Information of China (English)

    Song Weiming; Hu Qilin; Chang Xuan; Chen Sanping; Xie Gang; Gao Shengli

    2006-01-01

    A ternary solid complex Yb(Et2dtc)3(phen) was obtained from the reaction of hydrous ytterbium chloride with sodium diethyldithiocarbamate (NaEt2dtc), and 1, 10-phenanthroline (o-phen·H2O) in absolute ethanol.The bonding characteristics of the complex were characterized by IR.The result shows Yb3+ bands with two sulfur atoms in the Na(Et2dtc)3 and two nitrogen atoms in the o-phen.The enthalpy change of liquid-phase reaction of formation of the complex ΔrHθm (l), was determined as being (-24.838±0.114) kJ·mol-1 at 298.15 K, by an RD-496 Ⅲ type heat conduction microcalormeter.The enthalpy change of the solid-phase reaction of formation of the complex ΔrHθm (s), was calculated as being (108.015±0.479) kJ·mol-1 on the basis of an appropriate thermochemistry cycle.The thermodynamics of liquid-phase reaction of formation of the complex was investigated by changing the temperature during the liquid-phase reaction.Fundamental parameters, the activation enthalpy, ΔHθ≠, the activation entropy, ΔSθ≠, the activation free energy, ΔGθ≠, the apparent reaction rate constant k, the apparent activation energy E, the pre-exponential constant A, and the reaction order n, were obtained by a combination of the reaction thermodynamic and kinetic equations with the data from the thermokinetic experiments.At the same time, the molar heat capacity of the complex cm, p, was determined to be (86.34±1.74) J·mol-1·K-1 by the same microcalormeter.The constant-volume combustion energy of the complex, ΔcU, was determined to be (-17954.08±8.11) kJ·mol-1 by an RBC-Ⅱ type rotating-bomb calorimeter at 298.15 K.Its standard enthalpy of combustion, ΔcHθm, and standard enthalpy of formation, ΔfHθm, were calculated to be (-17973.29±8.11) kJ·mol-1 and (-770.36±9.02) kJ·mol-1, respectively.

  13. Does upper premolar extraction affect the changes of pharyngeal airway volume after bimaxillary surgery in skeletal class III patients?

    Science.gov (United States)

    Kim, Min-Ah; Park, Yang-Ho

    2014-01-01

    The purpose of this study was to assess the pharyngeal airway volume change after bimaxillary surgery in patients with skeletal Class III malocclusion and evaluate the difference in postoperative pharyngeal airway space between upper premolar extraction cases and nonextraction cases. Cone-beam computed tomographic scans were obtained for 23 patients (13 in extraction group and 10 in nonextraction group) who were diagnosed with mandibular prognathism before surgery (T0) and then 2 months (T2) and 6 months after surgery (T3). Using InVivoDental 3-dimensional imaging software, volumetric changes in the pharyngeal airway space were assessed at T0, T2, and T3. The Wilcoxon signed-rank test was used to determine whether there were significant changes in pharyngeal airway volume between time points. The Mann-Whitney U test was used to determine whether there were significant differences in volumetric changes between the extraction and nonextraction groups. Volumes in all subsections of the pharyngeal airway were decreased (P bimaxillary surgery. Copyright © 2014 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  14. Effects of prenatal alcohol exposure on the development of white matter volume and change in executive function

    Directory of Open Access Journals (Sweden)

    P. Gautam

    2014-01-01

    Full Text Available Prenatal alcohol exposure can cause a wide range of deficits in executive function that persist throughout life, but little is known about how changes in brain structure relate to cognition in affected individuals. In the current study, we predicted that the rate of white matter volumetric development would be atypical in children with fetal alcohol spectrum disorders (FASD when compared to typically developing children, and that the rate of change in cognitive function would relate to differential white matter development between groups. Data were available for 103 subjects [49 with FASD, 54 controls, age range 6–17, mean age = 11.83] with 153 total observations. Groups were age-matched. Participants underwent structural magnetic resonance imaging (MRI and an executive function (EF battery. Using white matter volumes measured bilaterally for frontal and parietal regions and the corpus callosum, change was predicted by modeling the effects of age, intracranial volume, sex, and interactions with exposure status and EF measures. While both groups showed regional increases in white matter volumes and improvement in cognitive performance over time, there were significant effects of exposure status on age-related relationships between white matter increases and EF measures. Specifically, individuals with FASD consistently showed a positive relationship between improved cognitive function and increased white matter volume over time, while no such relationships were seen in controls. These novel results relating improved cognitive function with increased white matter volume in FASD suggest that better cognitive outcomes could be possible for FASD subjects through interventions that enhance white matter plasticity.

  15. Semiautomated three-dimensional segmentation software to quantify carpal bone volume changes on wrist CT scans for arthritis assessment.

    Science.gov (United States)

    Duryea, J; Magalnick, M; Alli, S; Yao, L; Wilson, M; Goldbach-Mansky, R

    2008-06-01

    Rapid progression of joint destruction is an indication of poor prognosis in patients with rheumatoid arthritis. Computed tomography (CT) has the potential to serve as a gold standard for joint imaging since it provides high resolution three-dimensional (3D) images of bone structure. The authors have developed a method to quantify erosion volume changes on wrist CT scans. In this article they present a description and validation of the methodology using multiple scans of a hand phantom and five human subjects. An anthropomorphic hand phantom was imaged with a clinical CT scanner at three different orientations separated by a 30-deg angle. A reader used the semiautomated software tool to segment the individual carpal bones of each CT scan. Reproducibility was measured as the root-mean-square standard deviation (RMMSD) and coefficient of variation (CoV) between multiple measurements of the carpal volumes. Longitudinal erosion progression was studied by inserting simulated erosions in a paired second scan. The change in simulated erosion size was calculated by performing 3D image registration and measuring the volume difference between scans in a region adjacent to the simulated erosion. The RMSSD for the total carpal volumes was 21.0 mm3 (CoV = 1.3%) for the phantom, and 44.1 mm3 (CoV = 3.0%) for the in vivo subjects. Using 3D registration and local volume difference calculations, the RMMSD was 1.0-3.0 mm3 The reader time was approximately 5 min per carpal bone. There was excellent agreement between the measured and simulated erosion volumes. The effect of a poorly measured volume for a single erosion is mitigated by the large number of subjects that would comprise a clinical study and that there will be many erosions measured per patient. CT promises to be a quantifiable tool to measure erosion volumes and may serve as a gold standard that can be used in the validation of other modalities such as magnetic resonance imaging.

  16. Long-term global and regional brain volume changes following severe traumatic brain injury: A longitudinal study with clinical correlates

    DEFF Research Database (Denmark)

    Sidaros, Annette; Skimminge, Arnold Jesper Møller; Liptrot, Matthew George;

    2009-01-01

    Traumatic brain injury (TBI) results in neurodegenerative changes that progress for months, perhaps even years post-injury. However, there is little information on the spatial distribution and the clinical significance of this late atrophy. In 24 patients who had sustained severe TBI we acquired 3D...... scan time point using SIENAX. Regional distribution of atrophy was evaluated using tensor-based morphometry (TBM). At the first scan time point, brain parenchymal volume was reduced by mean 8.4% in patients as compared to controls. During the scan interval, patients exhibited continued atrophy...... with percent brain volume change (%BVC) ranging between − 0.6% and − 9.4% (mean − 4.0%). %BVC correlated significantly with injury severity, functional status at both scans, and with 1-year outcome. Moreover, %BVC improved prediction of long-term functional status over and above what could be predicted using...

  17. Exponential Disks from Stellar Scattering: III. Stochastic Models

    CERN Document Server

    Elmegreen, Bruce G

    2016-01-01

    Stellar scattering off irregularities in a galaxy disk has been shown to make an exponential radial profile, but no fundamental reason for this has been suggested. Here we show that exponentials are mathematically expected from random scattering in a disk when there is a slight inward bias in the scattering probability. Such a bias was present in our previous scattering experiments that formed exponential profiles. Double exponentials can arise when the bias varies with radius. This is a fundamental property of scattering and may explain why piece-wise exponential profiles are ubiquitous in galaxies, even after minor mergers and other disruptive events.

  18. Numerical study of MHD nanofluid flow and heat transfer past a bidirectional exponentially stretching sheet

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, Rida [School of Natural Sciences (SNS), National University of Sciences and Technology (NUST), Islamabad 44000 (Pakistan); Mustafa, M., E-mail: meraj_mm@hotmail.com [School of Natural Sciences (SNS), National University of Sciences and Technology (NUST), Islamabad 44000 (Pakistan); Hayat, T. [Department of Mathematics, Quaid-I-Azam University 45320, Islamabad 44000 (Pakistan); Department of Mathematics, Faculty of Science, King Abdulaziz University, P.O. Box 80257, Jeddah 21589 (Saudi Arabia); Alsaedi, A. [Department of Mathematics, Faculty of Science, King Abdulaziz University, P.O. Box 80257, Jeddah 21589 (Saudi Arabia)

    2016-06-01

    Recent advancements in nanotechnology have led to the discovery of new generation coolants known as nanofluids. Nanofluids possess novel and unique characteristics which are fruitful in numerous cooling applications. Current work is undertaken to address the heat transfer in MHD three-dimensional flow of magnetic nanofluid (ferrofluid) over a bidirectional exponentially stretching sheet. The base fluid is considered as water which consists of magnetite–Fe{sub 3}O{sub 4} nanoparticles. Exponentially varying surface temperature distribution is accounted. Problem formulation is presented through the Maxwell models for effective electrical conductivity and effective thermal conductivity of nanofluid. Similarity transformations give rise to a coupled non-linear differential system which is solved numerically. Appreciable growth in the convective heat transfer coefficient is observed when nanoparticle volume fraction is augmented. Temperature exponent parameter serves to enhance the heat transfer from the surface. Moreover the skin friction coefficient is directly proportional to both magnetic field strength and nanoparticle volume fraction. - Highlights: • Nanofluid flow due to exponentially stretching sheet. • Exponentially varying surface temperature distribution is accounted. • Sparrow–Gregg type Hills (SGH) for temperature distribution exist. • Numerical values of local Nusselt number are presented. • Cooling performance of ferrofluid is superior to pure water.

  19. Early changes in left atrial volume after acute myocardial infarction. Relation to invasive hemodynamics at rest and during exercise

    DEFF Research Database (Denmark)

    Bakkestrøm, Rine; Andersen, Mads J; Ersbøll, Mads

    2016-01-01

    BACKGROUND: Dilatation of left atrium (LA) reflects chronic LA pressure or volume overload that possesses considerable prognostic information. Little is known regarding the interaction between LA remodeling after acute myocardial infarction (MI) and left atrial pressure at rest and during exercise...... associated with resting and exercise induced changes in LA pressure overload. The dilatation was however associated with lower e' and higher MR-proANP....

  20. Quantum-Mechanical QSPR Models for Polymerization Volume Change of Epoxides and Methacrylates Based on Mercury Dilatometry Results

    OpenAIRE

    Miller, Matthew D.; Holder, Andrew J.; Kilway, Kathleen V.; Giese, Gregory J.; Finley, Jason E.; Travis, DeAnna M.; Iwai, Benjamin T.; Eick, J. David

    2006-01-01

    Polymerization volume change (PVC) was measured systematically using mercury dilatometry for 41 epoxide and methacrylate monomers with quartz filler. Quantitative structure property relationship (QSPR) models were developed based on this previously unreported data to gain insight in the data collection method for future models. Successful models included only data from those samples which polymerized to hardness. The most significant descriptors in these models related to monomer reactivity. ...

  1. Changes in hippocampal volume and neuron number co-occur with memory decline in old homing pigeons (Columba livia).

    Science.gov (United States)

    Coppola, Vincent J; Kanyok, Nate; Schreiber, Austin J; Flaim, Mary E; Bingman, Verner P

    2016-05-01

    The mammalian hippocampus is particularly susceptible to age-related structural changes, which have been used to explain, in part, age-related memory decline. These changes are generally characterized by atrophy (e.g., a decrease in volume and number of synaptic contacts). Recent studies have reported age-related spatial memory deficits in older pigeons similar to those seen in older mammals. However, to date, little is known about any co-occurring changes in the aging avian hippocampal formation (HF). In the current study, it was found that the HF of older pigeons was actually larger and contained more neurons than the HF of younger pigeons, a finding that suggests that the pattern of structural changes during aging in the avian HF is different from that seen in the mammalian hippocampus. A working hypothesis for relating the observed structural changes with spatial-cognitive decline is offered.

  2. An exponentiation method for XML element retrieval.

    Science.gov (United States)

    Wichaiwong, Tanakorn

    2014-01-01

    XML document is now widely used for modelling and storing structured documents. The structure is very rich and carries important information about contents and their relationships, for example, e-Commerce. XML data-centric collections require query terms allowing users to specify constraints on the document structure; mapping structure queries and assigning the weight are significant for the set of possibly relevant documents with respect to structural conditions. In this paper, we present an extension to the MEXIR search system that supports the combination of structural and content queries in the form of content-and-structure queries, which we call the Exponentiation function. It has been shown the structural information improve the effectiveness of the search system up to 52.60% over the baseline BM25 at MAP.

  3. On exponential stabilizability of linear neutral systems

    Directory of Open Access Journals (Sweden)

    Dusser Xavier

    2001-01-01

    Full Text Available In this paper, we deal with linear neutral functional differential systems. Using an extended state space and an extended control operator, we transform the initial neutral system in an infinite dimensional linear system. We give a sufficient condition for admissibility of the control operator B , conditions under which operator B can be acceptable in order to work with controllability and stabilizability. Necessary and sufficient conditions for exact controllability are provided; in terms of a gramian of controllability N ( μ . Assuming admissibility and exact controllability, a feedback control law is defined from the inverse of the operator N ( μ in order to stabilize exponentially the closed loop system. In this case, the semigroup generated by the closed loop system has an arbitrary decay rate.

  4. Controlling chaos using an exponential control

    CERN Document Server

    Gadre, S D; Gadre, Sangeeta D; Varma, V S

    1995-01-01

    We demonstrate that chaos can be controlled using a multiplicative exponential feedback control. All three types of unstable orbits - unstable fixed points, limit cycles and chaotic trajectories can be stabilized using this control. The control is effective both for maps and flows. The control is significant, particularly for systems with several degrees of freedom, as knowledge of only one variable on the desired unstable orbit is sufficient to settle the system on to that orbit. We find, that in all the cases studied, the transient time is a decreasing function of the stiffness of control. But increasing the stiffness beyond an optimum value can increase the transient time. The control can also be used to create suitable new stable attractors in a map, which did not exist in the original system.

  5. Poissonian renormalizations, exponentials, and power laws

    Science.gov (United States)

    Eliazar, Iddo

    2013-05-01

    This paper presents a comprehensive “renormalization study” of Poisson processes governed by exponential and power-law intensities. These Poisson processes are of fundamental importance, as they constitute the very bedrock of the universal extreme-value laws of Gumbel, Fréchet, and Weibull. Applying the method of Poissonian renormalization we analyze the emergence of these Poisson processes, unveil their intrinsic dynamical structures, determine their domains of attraction, and characterize their structural phase transitions. These structural phase transitions are shown to be governed by uniform and harmonic intensities, to have universal domains of attraction, to uniquely display intrinsic invariance, and to be intimately connected to “white noise” and to “1/f noise.” Thus, we establish a Poissonian explanation to the omnipresence of white and 1/f noises.

  6. Generalized exponential function and discrete growth models

    Science.gov (United States)

    Souto Martinez, Alexandre; Silva González, Rodrigo; Lauri Espíndola, Aquino

    2009-07-01

    Here we show that a particular one-parameter generalization of the exponential function is suitable to unify most of the popular one-species discrete population dynamic models into a simple formula. A physical interpretation is given to this new introduced parameter in the context of the continuous Richards model, which remains valid for the discrete case. From the discretization of the continuous Richards’ model (generalization of the Gompertz and Verhulst models), one obtains a generalized logistic map and we briefly study its properties. Notice, however that the physical interpretation for the introduced parameter persists valid for the discrete case. Next, we generalize the (scramble competition) θ-Ricker discrete model and analytically calculate the fixed points as well as their stabilities. In contrast to previous generalizations, from the generalized θ-Ricker model one is able to retrieve either scramble or contest models.

  7. Nonlinear elliptic systems with exponential nonlinearities

    Directory of Open Access Journals (Sweden)

    Said El Manouni

    2002-12-01

    Full Text Available In this paper we investigate the existence of solutions for {gather*} -mathop{m div}( a(| abla u | ^N| abla u |^{N-2}u = f(x,u,v quad mbox{in } Omega -mathop{m div}(a(| abla v| ^N| abla v |^{N-2}v = g(x,u,v quad mbox{in } Omega u(x = v(x = 0 quad mbox{on }partial Omega. end{gather*} Where $Omega$ is a bounded domain in ${mathbb{R}}^N$, $Ngeq 2$, $f$ and $g$ are nonlinearities having an exponential growth on $Omega$ and $a$ is a continuous function satisfying some conditions which ensure the existence of solutions.

  8. Exponential Networks and Representations of Quivers

    CERN Document Server

    Eager, Richard; Walcher, Johannes

    2016-01-01

    We study the geometric description of BPS states in supersymmetric theories with eight supercharges in terms of geodesic networks on suitable spectral curves. We lift and extend several constructions of Gaiotto-Moore-Neitzke from gauge theory to local Calabi-Yau threefolds and related models. The differential is multi-valued on the covering curve and features a new type of logarithmic singularity in order to account for D0-branes and non-compact D4-branes, respectively. We describe local rules for the three-way junctions of BPS trajectories relative to a particular framing of the curve. We reproduce BPS quivers of local geometries and illustrate the wall-crossing of finite-mass bound states in several new examples. We describe first steps toward understanding the spectrum of framed BPS states in terms of such "exponential networks."

  9. Transient accelerating scalar models with exponential potentials

    Institute of Scientific and Technical Information of China (English)

    Wen-Ping Cui; Yang Zhang; Zheng-Wen Fu

    2013-01-01

    We study a known class of scalar dark energy models in which the potential has an exponential term and the current accelerating era is transient.We find that,although a decelerating era will return in the future,when extrapolating the model back to earlier stages (z(≥) 4),scalar dark energy becomes dominant over matter.So these models do not have the desired tracking behavior,and the predicted transient period of acceleration cannot be adopted into the standard scenario of the Big Bang cosmology.When couplings between the scalar field and matter are introduced,the models still have the same problem; only the time when deceleration returns will be varied.To achieve re-deceleration,one has to turn to alternative models that are consistent with the standard Big Bang scenario.

  10. An Economic Model of Coupled Exponential Maps

    CERN Document Server

    López-Ruiz, R; Cosenza, M G; Sánchez, J R

    2007-01-01

    In this work, an ensemble of economic interacting agents is considered. The agents are arranged in a linear array where only local couplings are allowed. The deterministic dynamics of each agent is given by a map. This map is expressed by two factors. The first one is a linear term that models the expansion of the agent's economy and that is controlled by the {\\it growth capacity parameter}. The second one is an inhibition exponential term that is regulated by the {\\it local environmental pressure}. Depending on the parameter setting, the system can display Pareto or Boltzmann-Gibbs behavior in the asymptotic dynamical regime. The regions of parameter space where the system exhibits one of these two statistical behaviors are delimited. Other properties of the system, such as the mean wealth, the standard deviation and the Gini coefficient, are also calculated.

  11. Modeling Aftershocks as a Stretched Exponential Relaxation

    CERN Document Server

    Mignan, Arnaud

    2015-01-01

    The decay rate of aftershocks has been modeled as a power law since the pioneering work of Omori in the late nineteenth century. Considered the second most fundamental empirical law after the Gutenberg-Richter relationship, the power law paradigm has rarely been challenged by the seismological community. By taking a view of aftershock research not biased by prior conceptions of Omori power law decay and by applying statistical methods recommended in applied mathematics, I show that all aftershock sequences tested in three regional earthquake catalogs (Southern and Northern California, Taiwan) and with three declustering techniques (nearest-neighbor, second-order moment, window methods) follow a stretched exponential instead of a power law. These results infer that aftershocks are due to a simpler relaxation process than originally thought, in accordance with most other relaxation processes observed in Nature.

  12. Poissonian renormalizations, exponentials, and power laws.

    Science.gov (United States)

    Eliazar, Iddo

    2013-05-01

    This paper presents a comprehensive "renormalization study" of Poisson processes governed by exponential and power-law intensities. These Poisson processes are of fundamental importance, as they constitute the very bedrock of the universal extreme-value laws of Gumbel, Fréchet, and Weibull. Applying the method of Poissonian renormalization we analyze the emergence of these Poisson processes, unveil their intrinsic dynamical structures, determine their domains of attraction, and characterize their structural phase transitions. These structural phase transitions are shown to be governed by uniform and harmonic intensities, to have universal domains of attraction, to uniquely display intrinsic invariance, and to be intimately connected to "white noise" and to "1/f noise." Thus, we establish a Poissonian explanation to the omnipresence of white and 1/f noises.

  13. Pituitary volumes of the patients with borderline personality disorder are not changed.

    Science.gov (United States)

    Atmaca, Murad; Karakoc, Tevfik; Mermi, Osman; Kilic, Faruk; Gurok, M Gurkan; Yildirim, Hanefi

    2015-01-01

    Although it has important relationships with psychiatric symptoms via the hypothalamic-pituitary-adrenal axis, there have been limited investigations of pituitary neuroimaging in psychiatric disorder. Moreover, there have been no studies of borderline personality disorder. In the present investigation, we examined pituitary gland volumes in patients with borderline personality disorder. Seventeen right-handed female patients with borderline personality disorder, selected among the patients who had presented to Firat University School of Medicine Department of Psychiatry outpatient and inpatient clinics, and the same number of healthy control subjects were included in the present investigation. Pituitary gland volumes were manually detected. The results demonstrated that the mean volumes of the gland of the patients with borderline personality disorder were not significantly different than those of healthy control subjects (mean volume of 0.79 cm3 in the patient group, with a value of SD±0.11 and 0.81 cm3 in the healthy control group, with a value of SD±0.23; t=-0.21; p>0.05). © The Author(s) 2015.

  14. Estimating changes in Stroke Volume by non-invasive pulse-oximetry Pulse Transit Time Measurements

    NARCIS (Netherlands)

    ten Bokkel-Andela, J.; Poterman, Marieke; Scheeren, Thomas; Kalmar, A.F.

    2015-01-01

    Background and Goal of Study:  Pulse wave transit time (PTT), the interval between the R-wave peak on an electrocardiogram (ECG) and arrival of the pulse waves in the periphery (e.g. the finger), is reported to be a reliable estimate for stroke volume[1,2]. In this study, the PTT based on ECG and th

  15. Exponential Approximations Using Fourier Series Partial Sums

    Science.gov (United States)

    Banerjee, Nana S.; Geer, James F.

    1997-01-01

    The problem of accurately reconstructing a piece-wise smooth, 2(pi)-periodic function f and its first few derivatives, given only a truncated Fourier series representation of f, is studied and solved. The reconstruction process is divided into two steps. In the first step, the first 2N + 1 Fourier coefficients of f are used to approximate the locations and magnitudes of the discontinuities in f and its first M derivatives. This is accomplished by first finding initial estimates of these quantities based on certain properties of Gibbs phenomenon, and then refining these estimates by fitting the asymptotic form of the Fourier coefficients to the given coefficients using a least-squares approach. It is conjectured that the locations of the singularities are approximated to within O(N(sup -M-2), and the associated jump of the k(sup th) derivative of f is approximated to within O(N(sup -M-l+k), as N approaches infinity, and the method is robust. These estimates are then used with a class of singular basis functions, which have certain 'built-in' singularities, to construct a new sequence of approximations to f. Each of these new approximations is the sum of a piecewise smooth function and a new Fourier series partial sum. When N is proportional to M, it is shown that these new approximations, and their derivatives, converge exponentially in the maximum norm to f, and its corresponding derivatives, except in the union of a finite number of small open intervals containing the points of singularity of f. The total measure of these intervals decreases exponentially to zero as M approaches infinity. The technique is illustrated with several examples.

  16. Online System Identification Method Using Modified Regularized Exponential Forgetting

    Directory of Open Access Journals (Sweden)

    Ján VACHÁLEK

    2013-12-01

    Full Text Available The paper deals with the use of regularized exponential forgetting (REF in the process of online system identification. The deployment of this type of forgetting strategy is advantageous for very long runs with small changes in the identified input parameters (in the range of 100 000 steps. In these cases, the classical methods of forgetting, such as an exponential (EF or directional forgetting (DF lack the required quality and reach the limit of numerical stability of the calculations of system parameters, which may lead to the early termination of system identification procedure. To avoid this undesirable effect and maintain sufficient primary information about the identified system, a modified REF method is used that employs alternative covariance matrix (ACM formulation to store the primary information of the identified system (REFACM and prevents the numerical destabilization of the identification process. The quality of the modified REFACM forgetting method —along with its validation and comparison with REZ to verify its properties—is performed using standard tests.

  17. Exponential decay and scaling laws in noisy chaotic scattering

    Energy Technology Data Exchange (ETDEWEB)

    Seoane, Jesus M. [Nonlinear Dynamics and Chaos Group, Departamento de Fisica, Universidad Rey Juan Carlos, Tulipan s/n, 28933 Mostoles, Madrid (Spain)], E-mail: jesus.seoane@urjc.es; Sanjuan, Miguel A.F. [Nonlinear Dynamics and Chaos Group, Departamento de Fisica, Universidad Rey Juan Carlos, Tulipan s/n, 28933 Mostoles, Madrid (Spain)], E-mail: miguel.sanjuan@urjc.es

    2008-01-07

    In this Letter we present a numerical study of the effect of noise on a chaotic scattering problem in open Hamiltonian systems. We use the second order Heun method for stochastic differential equations in order to integrate the equations of motion of a two-dimensional flow with additive white Gaussian noise. We use as a prototype model the paradigmatic Henon-Heiles Hamiltonian with weak dissipation which is a well-known example of a system with escapes. We study the behavior of the scattering particles in the scattering region, finding an abrupt change of the decay law from algebraic to exponential due to the effects of noise. Moreover, we find a linear scaling law between the coefficient of the exponential law and the intensity of noise. These results are of a general nature in the sense that the same behavior appears when we choose as a model a two-dimensional discrete map with uniform noise (bounded in a particular interval and zero otherwise), showing the validity of the algorithm used. We believe the results of this work be useful for a better understanding of chaotic scattering in more realistic situations, where noise is presented.

  18. Exponential parameterization of the neutrino mixing matrix: comparative analysis with different data sets and CP violation

    Energy Technology Data Exchange (ETDEWEB)

    Zhukovsky, K.; Borisov, A. [M.V. Lomonosov Moscow State University, Department of Theoretical Physics, Faculty of Physics, Moscow (Russian Federation)

    2016-11-15

    The exponential parameterization of the Pontecorvo-Maki-Nakagawa-Sakata mixing matrix for neutrino is used for a comparative analysis of different neutrino mixing data. The U{sub PMNS} matrix is considered as the element of the SU(3) group and the second-order matrix polynomial is constructed for it. The inverse problem of constructing the logarithm of the mixing matrix is addressed. In this way the standard parameterization is exactly related to the exponential parameterization. The exponential form allows easy factorization and separate analysis of the rotation and the CP violation. With the most recent experimental data on neutrino mixing (May 2016), we calculate the values of the exponential parameterization matrix for neutrinos with account for the CP violation. The complementarity hypothesis for quarks and neutrinos is demonstrated to hold, despite a significant change in the neutrino mixing data. The values of the entries of the exponential mixing matrix are evaluated with account for the actual degree of the CP violation in neutrino mixing and without it. Various factorizations of the CP-violating term are investigated in the framework of the exponential parameterization. (orig.)

  19. Confined-Volume Effect on the Thermal Properties of Encapsulated Phase Change Materials for Thermal Energy Storage.

    Science.gov (United States)

    De Castro, Paula F; Ahmed, Adham; Shchukin, Dmitry G

    2016-03-18

    We have encapsulated the heat exchange material, n-docosane, into polyurethane capsules of different sizes. Decreasing the size of the capsules leads to changes of the crystallinity of phase-change material as well as melting/crystallization temperature. The novelty of the paper includes 1) protection of the nanostructured energy-enriched materials against environment during storage and controlled release of the encapsulated energy on demand and 2) study of the structure and surface-to-volume properties of the energy-enriched materials dispersed in capsules of different sizes. The stability of energy nanomaterials, influence of capsule diameter on their energy capacity, homogeneity and operation lifetime are investigated.

  20. Impact of the volume change on the ageing effects in Cu-Al-Ni martensite: experiment and theory.

    Science.gov (United States)

    Kosogor, Anna; Xue, Dezhen; Zhou, Yumei; Ding, Xiangdong; Otsuka, Kazuhiro; L'vov, Victor A; Sun, Jun; Ren, Xiaobing

    2013-08-21

    The time evolution of the physical properties of martensite during martensite ageing is traditionally explained by the symmetry-conforming short-range order (SC-SRO) principle, which requires the spatial configuration of crystal defects to follow the symmetry change of the host lattice. In the present study, we show that the volume change of the host lattice also contributes to the ageing effects in Cu-Al-Ni shape memory alloy besides the symmetry change. To substantiate this statement the gradual increase of the storage modulus with time at constant temperature was measured by dynamic mechanical analysis (DMA) and the experimental results were quantitatively described in the framework of the symmetry-conforming Landau theory of martensitic transformations in a crystal with defects. The comparison of experimental and theoretical results confirmed that the time dependence of the storage modulus is caused by two different physical mechanisms. Evaluations showing that the first mechanism is driven by the spontaneous symmetry change and the second mechanism is caused by the volume change after the martensitic transformation was carried out.

  1. Glacial – interglacial atmospheric CO2 change: a possible "standing volume" effect on deep-ocean carbon sequestration

    Directory of Open Access Journals (Sweden)

    L. C. Skinner

    2009-05-01

    Full Text Available So far, the exploration of possible mechanisms for glacial atmospheric CO2 draw-down and marine carbon sequestration has focussed almost exclusively on dynamic or kinetic processes (i.e. variable mixing-, equilibration- or export rates. Here an attempt is made to underline instead the possible importance of changes in the standing volumes of intra-oceanic carbon reservoirs (i.e. different water-masses in setting the total marine carbon inventory. By way of illustration, a simple mechanism is proposed for enhancing the carbon storage capacity of the deep sea, which operates via an increase in the volume of relatively carbon-enriched AABW-like deep-water filling the ocean basins. Given the hypsometry of the ocean floor and an active biological pump, the water-mass that fills more than the bottom 3 km of the ocean will essentially determine the carbon content of the marine reservoir. A set of simple box-model experiments confirm the expectation that a deep sea dominated by AABW-like deep-water holds more CO2, prior to any additional changes in ocean overturning rate, biological export or ocean-atmosphere exchange. The magnitude of this "standing volume effect" might be as large as the contributions that have been attributed to carbonate compensation, the thermodynamic solubility pump or the biological pump for example. If incorporated into the list of factors that have contributed to marine carbon sequestration during past glaciations, this standing volume mechanism may help to reduce the amount of glacial – interglacial CO2 change that remains to be explained by other mechanisms that are difficult to assess in the geological archive, such as reduced mass transport or mixing rates in particular. This in turn could help narrow the search for forcing conditions capable of pushing the global carbon cycle between glacial and interglacial modes.

  2. Evidence for a multi-species coccolith volume change over the past two centuries: understanding a potential ocean acidification response

    Directory of Open Access Journals (Sweden)

    P. R. Halloran

    2008-12-01

    Full Text Available Major questions surround the species-specific nature of coccolithophore calcification in response to rising atmospheric CO2 levels. Here we present CaCO3 particle volume distribution data from the coccolith size-fraction of a rapidly accumulating North Atlantic sediment core. Without direct volume measurements on coccoliths produced by individual coccolithophore species, and knowledge of organic, as well as inorganic carbon production, it is not possible to state conclusively the coccolithophore calcification change at this site. However, by analysing the size distribution of CaCO3 particles in the less than 10 μm sediment fraction, we demonstrate a changing particle volume since the late 20th Century consistent with an increase in the mass of coccoliths produced by the larger coccolithophore species, and potentially a decrease in mass of coccoliths produced by the smaller species, present at this location. This finding has significant implications for the realistic representation of an assemblage-wide coccolithophore CO2-calcification response in numerical models.

  3. Forearm skin tissue dielectric constant measured at 300 MHz: effect of changes in skin vascular volume and blood flow.

    Science.gov (United States)

    Mayrovitz, Harvey N; Guo, Xiaoran; Salmon, Mark; Uhde, Matt

    2013-01-01

    Skin tissue dielectric constant (TDC) values measured via the open-ended coaxial probe method are useful non-invasive indices of local skin tissue water. However, the effect of skin blood flow (SBF) or skin blood volume (SBV) on TDC values is unknown. To determine the magnitude of such effects, we decreased forearm SBV via vertical arm raising for 5 min (test 1) and increased SBV by bicep cuff compression to 50 mmHg for 5 min (test 2) in 20 healthy supine subjects (10 men). TDC values were measured to a depth of 1·5 mm on anterior forearm, and SBF was measured with laser-Doppler system simultaneously on forearm and finger. Results indicate that decreasing vascular volume (test 1) was associated with a small but statistically significant reduction in TDC (3·0 ± 4·3%, P = 0·003) and increasing vascular volume (test 2) was associated with a slight but statistically significant increase in TDC (3·5 ± 3·0%, PTDC values (3·0-3·5%) over the wide range of induced SBV and SBF changes suggest a minor effect on clinically determined TDC values because of SBV or SBF changes or differences when comparing TDC longitudinally over time or among individuals of different groups in a research setting.

  4. A MODEL TO ESTIMATE VOLUME CHANGE DUE TO RADIOLYTIC GAS BUBBLES AND THERMAL EXPANSION IN SOLUTION REACTORS

    Energy Technology Data Exchange (ETDEWEB)

    F. SOUTO; A HEGER

    2001-02-01

    Aqueous homogeneous solution reactors have been proposed for the production of medical isotopes. However, the reactivity effects of fuel solution volume change, due to formation of radiolytic gas bubbles and thermal expansion, have to be mitigated to allow steady-state operation of solution reactors. The results of the free run experiments analyzed indicate that the proposed model to estimate the void volume due to radiolytic gas bubbles and thermal expansion in solution reactors can accurately describe the observed behavior during the experiments. This void volume due to radiolytic gas bubbles and fuel solution thermal expansion can then be used in the investigation of reactivity effects in fissile solutions. In addition, these experiments confirm that the radiolytic gas bubbles are formed at a higher temperature than the fuel solution temperature. These experiments also indicate that the mole-weighted average for the radiolytic gas bubbles in uranyl fluoride solutions is about 1 {micro}m. Finally, it should be noted that another model, currently under development, would simulate the power behavior during the transient given the initial fuel solution level and density. The model is based on Monte Carlo simulation with the MCNP computer code [Briesmeister, 1997] to obtain the reactor reactivity as a function of the fuel solution density, which, in turn, changes due to thermal expansion and radiolytic gas bubble formation.

  5. Deformed Algebras and Generalizations of Independence on Deformed Exponential Families

    Directory of Open Access Journals (Sweden)

    Hiroshi Matsuzoe

    2015-08-01

    Full Text Available A deformed exponential family is a generalization of exponential families. Since the useful classes of power law tailed distributions are described by the deformed exponential families, they are important objects in the theory of complex systems. Though the deformed exponential families are defined by deformed exponential functions, these functions do not satisfy the law of exponents in general. The deformed algebras have been introduced based on the deformed exponential functions. In this paper, after summarizing such deformed algebraic structures, it is clarified how deformed algebras work on deformed exponential families. In fact, deformed algebras cause generalization of expectations. The three kinds of expectations for random variables are introduced in this paper, and it is discussed why these generalized expectations are natural from the viewpoint of information geometry. In addition, deformed algebras cause generalization of independences. Whereas it is difficult to check the well-definedness of deformed independence in general, the κ-independence is always well-defined on κ-exponential families. This is one of advantages of κ-exponential families in complex systems. Consequently, we can well generalize the maximum likelihood method for the κ-exponential family from the viewpoint of information geometry.

  6. Recording and Calculating Gunshot Sound—Change of the Volume in Reference to the Distance

    Science.gov (United States)

    Nikolaos, Tsiatis E.

    2010-01-01

    An experiment was conducted in an open practice ground (shooting range) regarding the recording of the sound of gunshots. Shots were fired using various types of firearms (seven pistols, five revolvers, two submachine guns, one rifle, and one shotgun) in different calibers, from several various distances with reference to the recording sources. Both, a conventional sound level meter (device) and a measurement microphone were used, having been placed in a fixed point behind the shooting line. The sound of each shot was recorded (from the device). At the same time the signal received by the microphone was transferred to a connected computer through an appropriate audio interface with a pre-amplifier. Each sound wave was stored and depicted as a wave function. After the physic-mathematical analysis of these depictions, the volume was calculated in the accepted engineering units(Decibels or dB) of Sound Pressure Level (SPL). The distances from the recording sources were 9.60 meters, 14.40 m, 19.20 m, and 38.40 m. The experiment was carried out by using the following calibers: .22 LR, 6.35 mm(.25 AUTO), 7.62 mm Tokarev(7,62×25), 7.65 mm(.32 AUTO), 9 mm Parabellum(9×19), 9 mm Short(9×17), 9 mm Makarov(9×18), .45 AUTO, .32 S&W, .38 S&W, .38 SPECIAL, .357 Magnum, 7,62 mm Kalashnikov(7,62×39) and 12 GA. Tables are given for the environmental conditions (temperature, humidity, altitude & barometric pressure), the length of the barrel of each gun, technical characteristics of the used ammunition, as well as for the volume taken from the SLM. The data for the sound intensity were collected after 168 gunshots (158 single shot & 10 bursts). According to the results, a decreasing of the volume, equivalent to the increasing of the distance, was remarked, as it was expected. Values seem to follow the Inverse square Law. For every doubling of the distance from the sound source, the sound intensity diminishes by 5.9904±0.2325 decibels (on average). In addition, we have the

  7. Static vortices in long Josephson junctions of exponentially varying width

    Science.gov (United States)

    Semerdjieva, E. G.; Boyadjiev, T. L.; Shukrinov, Yu. M.

    2004-06-01

    A numerical simulation is carried out for static vortices in a long Josephson junction with an exponentially varying width. At specified values of the parameters the corresponding boundary-value problem admits more than one solution. Each solution (distribution of the magnetic flux in the junction) is associated to a Sturm-Liouville problem, the smallest eigenvalue of which can be used, in a first approximation, to assess the stability of the vortex against relatively small spatiotemporal perturbations. The change in width of the junction leads to a renormalization of the magnetic flux in comparison with the case of a linear one-dimensional model. The influence of the model parameters on the stability of the states of the magnetic flux is investigated in detail, particularly that of the shape parameter. The critical curve of the junction is constructed from pieces of the critical curves for the different magnetic flux distributions having the highest critical currents for the given magnetic field.

  8. Statistical modelling of agrometeorological time series by exponential smoothing

    Science.gov (United States)

    Murat, Małgorzata; Malinowska, Iwona; Hoffmann, Holger; Baranowski, Piotr

    2016-01-01

    Meteorological time series are used in modelling agrophysical processes of the soil-plant-atmosphere system which determine plant growth and yield. Additionally, long-term meteorological series are used in climate change scenarios. Such studies often require forecasting or projection of meteorological variables, eg the projection of occurrence of the extreme events. The aim of the article was to determine the most suitable exponential smoothing models to generate forecast using data on air temperature, wind speed, and precipitation time series in Jokioinen (Finland), Dikopshof (Germany), Lleida (Spain), and Lublin (Poland). These series exhibit regular additive seasonality or non-seasonality without any trend, which is confirmed by their autocorrelation functions and partial autocorrelation functions. The most suitable models were indicated by the smallest mean absolute error and the smallest root mean squared error.

  9. Black Hole Instabilities and Exponential Growth

    CERN Document Server

    Prabhu, Kartik

    2015-01-01

    Recently, a general analysis has been given of the stability with respect to axisymmetric perturbations of stationary-axisymmetric black holes and black branes in vacuum general relativity in arbitrary dimensions. It was shown that positivity of canonical energy on an appropriate space of perturbations is necessary and sufficient for stability. However, the notions of both "stability" and "instability" in this result are significantly weaker than one would like to obtain. In this paper, we prove that if a perturbation of the form $\\pounds_t \\delta g$---with $\\delta g$ a solution to the linearized Einstein equation---has negative canonical energy, then that perturbation must, in fact, grow exponentially in time. The key idea is to make use of the $t$- or ($t$-$\\phi$)-reflection isometry, $i$, of the background spacetime and decompose the initial data for perturbations into their odd and even parts under $i$. We then write the canonical energy as $\\mathscr E\\ = \\mathscr K + \\mathscr U$, where $\\mathscr K$ and $...

  10. On Simple Graphs Arising from Exponential Congruences

    Directory of Open Access Journals (Sweden)

    M. Aslam Malik

    2012-01-01

    Full Text Available We introduce and investigate a new class of graphs arrived from exponential congruences. For each pair of positive integers a and b, let G(n denote the graph for which V={0,1,…,n−1} is the set of vertices and there is an edge between a and b if the congruence ax≡b (mod n is solvable. Let n=p1k1p2k2⋯prkr be the prime power factorization of an integer n, where p1

  11. Twisted exponential sums of polynomials in one variable

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The twisted T-adic exponential sums associated to a polynomial in one variable are studied.An explicit arithmetic polygon in terms of the highest two exponents of the polynomial is proved to be a lower bound of the Newton polygon of the C-function of the twisted T-adic exponential sums.This bound gives lower bounds for the Newton polygon of the L-function of twisted p-power order exponential sums.

  12. An Exponential Lower Bound on OBDD Refutations for Pigeonhole Formulas

    CERN Document Server

    Tveretina, Olga; Zantema, Hans

    2009-01-01

    Haken proved that every resolution refutation of the pigeonhole formula has at least exponential size. Groote and Zantema proved that a particular OBDD computation of the pigeonhole formula has an exponential size. Here we show that any arbitrary OBDD refutation of the pigeonhole formula has an exponential size, too: we prove that the size of one of the intermediate OBDDs is at least $\\Omega(1.025^n)$.

  13. Exponential convergence rates for weighted sums in noncommutative probability space

    Science.gov (United States)

    Choi, Byoung Jin; Ji, Un Cig

    2016-11-01

    We study exponential convergence rates for weighted sums of successive independent random variables in a noncommutative probability space of which the weights are in a von Neumann algebra. Then we prove a noncommutative extension of the result for the exponential convergence rate by Baum, Katz and Read. As applications, we first study a large deviation type inequality for weighted sums in a noncommutative probability space, and secondly we study exponential convergence rates for weighted free additive convolution sums of probability measures.

  14. Pulmonary Edema and Plasma Volume Changes in Dysbarism. M.S. Thesis - Texas Univ.

    Science.gov (United States)

    Joki, J. A.

    1972-01-01

    Two groups of anesthetized, fasted pigs were utilized. One group of 13 animals (8.5 to 16.6 kilograms) was exposed to a high-pressure environment, and the other group of eight animals (6.9 to 20.0 kilograms) constituted the control group. The experimental group was subjected to an atmosphere of 90 percent nitrogen and 10 percent oxygen at a pressure of 50 psig for 30 minutes and then decompressed at a rate 10 psi/min. Plasma volumes, using both iodine-125-tagged-albumin and chromium-51-tagged-cell dilution techniques, were measured before, immediately after, and at 30 and 60 minutes after decompression. Aortic and right-ventricular systolic pressures were also recorded. At 60 minutes after decompression, blood samples were taken, the animals were sacrificed, and the water content of the lungs, kidneys, livers, and spleens was estimated by measuring tissue wet weight and dry weight. Protein extravasation and tissue blood volumes were determined by measuring the iodine-125-tagged-albumin and chromium-51-tagged-cell spaces in homo-genates of the organs under investigation.

  15. Changes in plasma volume during bed rest - Effects of menstrual cycle and estrogen administration

    Science.gov (United States)

    Fortney, S. M.; Beckett, W. S.; Carpenter, A. J.; Davis, J.; Drew, H.

    1988-01-01

    The effect of increased blood estrogen concentration, caused either during normal menstrual cycles or by exogenous administration of premarin, on the bed-rest (BR) induced decrease in plasma volume (PV) was investigated. In women who underwent duplicate 11-day BR without estrogen supplementation, the PV was found to decrease significantly, during the first 5 days of BR, to a lower level at which it remained for the rest of the BR period. In women who began BR in the periovulatory stage of the menstrual cycle, the loss of PV was delayed, while women who began BR during other stages of the cycle exhibited the usual trend of the PV decrease during the BR. In women who underwent a single 12-day BR period while taking premarin (1.25 mg/day), PV was found to decrease during the first 4-5 days of BR, but then returned toward the pre-BR level during the remainder of the BR, indicating that estrogens have a role in stabilizing body fluid volume.

  16. Quantifying seasonal volume of groundwater in high elevation meadows: Implications for complex aquifer geometry in a changing climate

    Science.gov (United States)

    Ciruzzi, Dominick M.

    The hydrologic impacts of rising global temperatures are severe and imminent particularly in snow-dominated regions. In the western United States, high elevation meadows are among the ecosystems highly sensitive to climate change. High elevation meadows are groundwater dependent ecosystems and rely on seasonal snowpack melt in order to support ecologic function and baseflow to streams. This stream flow in turn supplies an estimated 2.6 million San Francisco residents with water. Once the snow melts and recharges the aquifer, groundwater supports vegetation separate from the surrounding hillslopes, which promotes important ecologic functions like flood regulation and nutrient cycling. Groundwater also supports baseflow to perennial rivers late into the summer months transferring this snowmelt to downstream ecologic and human communities. By 2100 snowpack accumulation in the Sierra Nevada is expected to decrease by ~40-90% due to near-surface temperature rise. Though precipitation intensity is not expected to change, a decrease in snowpack will change the timing and magnitude of groundwater recharge necessary to sustain high elevation meadows. An additional climate-driven shift and decrease in peak stream flow to early spring away from summer when demand is highest puts into question ecosystem survivability and water supply to downstream users. Here, a new quantitative framework is presented to lay the foundation for the widespread identification of vulnerabilities in high elevation meadows due to climate change. This research proposed and tested a new conceptual model for the volume of groundwater stored in high elevation meadows similar to that of a reservoir with active and dead storage. The seasonal fluctuations in active storage, which is defined as the volume of groundwater able to exchange between the aquifer, streams, and vegetation, are thought to be highly sensitive to aquifer parameters, such as bedrock geometry, meadow gradient, and hydraulic conductivity

  17. The exponential-logarithmic equivalence classes of surreal numbers

    CERN Document Server

    Kuhlmann, Salma

    2012-01-01

    In his monograph, H. Gonshor showed that Conway's real closed field of surreal numbers carries an exponential and logarithmic map. Subsequently, L. van den Dries and P. Ehrlich showed that it is a model of the elementary theory of the field of real numbers with the exponential function. In this paper, we give a complete description of the exponential equivalence classes in the spirit of the classical Archimedean and multiplicative equivalence classes. This description is made in terms of a recursive formula as well as a sign sequence formula for the family of representatives of minimal length of these exponential classes.

  18. Using Differentials to Differentiate Trigonometric and Exponential Functions

    Science.gov (United States)

    Dray, Tevian

    2013-01-01

    Starting from geometric definitions, we show how differentials can be used to differentiate trigonometric and exponential functions without limits, numerical estimates, solutions of differential equations, or integration.

  19. Using Differentials to Differentiate Trigonometric and Exponential Functions

    Science.gov (United States)

    Dray, Tevian

    2013-01-01

    Starting from geometric definitions, we show how differentials can be used to differentiate trigonometric and exponential functions without limits, numerical estimates, solutions of differential equations, or integration.

  20. Local and global volume changes of subcortical brain structures from longitudinally varying neuroimaging data for dementia identification.

    Science.gov (United States)

    Unay, Devrim

    2012-09-01

    Quantification of structural changes in the human brain is important to elicit resemblances and differences between pathological and normal aging. Identification of dementia, associated with loss of cognitive ability beyond normal aging, and especially converters--the subgroup of individuals at risk for developing dementia--has recently gained importance. For this purpose atrophy markers have been explored and their effectiveness has been evaluated both cross-sectionally and longitudinally. However, more research is needed to understand the dynamics of atrophy markers at different disease stages, which requires temporal analysis of local along with global changes. Unfortunately, most of the longitudinal neuroimaging data available in the clinical settings is acquired at largely varying time intervals. In the light of the above, this study presents a novel methodology to process longitudinal neuroimaging data acquired incompletely and at different time intervals, and explores complementary nature of local and global brain volume changes in identifying dementia. Results on the OASIS database demonstrate discriminative power of global atrophy in hippocampus (as early as two years after the first visit) for identifying demented cases, and local volume shrinkage of thalamus proper (as early as three years after the first visit) for differentiating converters.

  1. Effect of change in blood volume in skin plus active muscle on heart rate drift during submaximal exercise

    OpenAIRE

    Yano,T.; T Yunoki; Matsuura, R.; Arimitsu, T.; Kimura, T.

    2008-01-01

    The purpose of the present study was to examine the effect of change in blood volume in skin plus active muscle on heart rate drift during moderate exercise and heavy exercise for 30 min. Total hemoglobin concentration (Total Hb) in the vastus lateralis muscle plus its skin was determined by near-infrared spectroscopy. Total Hb significantly increased and remained stable from 20 min in moderate exercise and from 10 min in heavy exercise. Heart rate (HR) rapidly increased until 3 min and showe...

  2. Local control of emission energy of semiconductor quantum dots using volume expansion of a phase-change material

    Science.gov (United States)

    Takahashi, Motoki; Syafawati Humam, Nurrul; Tsumori, Nobuhiro; Saiki, Toshiharu; Regreny, Philippe; Gendry, Michel

    2013-03-01

    A method is proposed to precisely control the emission energy of semiconductor quantum dots (QDs) by the application of local strain due to volume expansion of a phase-change material (GeSbTe) upon amorphization. The feasibility of the method is experimentally demonstrated using photoluminescence (PL) spectroscopy of single InAs/InP QDs on which a GeSbTe thin film is deposited. A significant red-shift of the PL peak energy upon amorphization and subsequent recovery by recrystallization with laser annealing were observed.

  3. A model to estimate volume change due to radiolytic gas bubbles and thermal expansion in solution reactors

    Energy Technology Data Exchange (ETDEWEB)

    Souto, F.J. [NIS-6: Advanced Nuclear Technology, Los Alamos National Lab., Los Alamos, NM (United States); Heger, A.S. [ESA-EA: Engineering Sciences and Application, Los Alamos National Lab., Los Alamos, NM (United States)

    2001-07-01

    To investigate the effects of radiolytic gas bubbles and thermal expansion on the steady-state operation of solution reactors at the power level required for the production of medical isotopes, a calculational model has been developed. To validate this model, including its principal hypotheses, specific experiments at the Los Alamos National Laboratory SHEBA uranyl fluoride solution reactor were conducted. The following sections describe radiolytic gas generation in solution reactors, the equations to estimate the fuel solution volume change due to radiolytic gas bubbles and thermal expansion, the experiments conducted at SHEBA, and the comparison of experimental results and model calculations. (author)

  4. Indication of BOLD-specific venous flow-volume changes from precisely controlled hyperoxic vs. hypercapnic calibration.

    Science.gov (United States)

    Mark, Clarisse I; Pike, G Bruce

    2012-04-01

    Deriving cerebral metabolic rate of oxygen consumption (CMRO(2)) from blood oxygenation level-dependent (BOLD) signals involves a flow-volume parameter (α), reflecting total cerebral blood volume changes, and a calibration constant (M). Traditionally, the former is assumed a fixed value and the latter is measured under alterations in fixed inspired fractional concentrations of carbon dioxide. We recently reported on reductions in M-variability via precise control of end-tidal pressures of both hypercapnic (HC) and hyperoxic (HO) gases. In light of these findings, our aim was to apply the improved calibration alternatives to neuronal activation, making use of their distinct vasoactive natures to evaluate the α-value. Nine healthy volunteers were imaged at 3 T while simultaneously measuring BOLD and arterial spin-labeling signals during controlled, graded, HC, and HO, followed by visual (VC) and sensorimotor cortices (SMC) activation. On the basis of low M- and CMRO(2)-variability, the comparison of these calibration alternatives accurately highlighted a reduced venous flow-volume relationship (α=0.16±0.02, with α(VC)=0.12±0.04, and α(SMC)=0.20±0.02), as appropriate for BOLD modeling.

  5. Morphologic Changes of Mammary Carcinomas in Mice over Time as Monitored by Flat-Panel Detector Volume Computed Tomography

    Directory of Open Access Journals (Sweden)

    Jeannine Missbach-Guentner

    2008-07-01

    Full Text Available Noninvasive methods are strongly needed to detect and quantify not only tumor growth in murine tumor models but also the development of vascularization and necrosis within tumors. This study investigates the use of a new imaging technique, flat-panel detector volume computed tomography (fpVCT, to monitor in vivo tumor progression and structural changes within tumors of two murine carcinoma models. After tumor cell inoculation, single fpVCT scans of the entire mice were performed at different time points. The acquired isotropic, high-resolution volume data sets enable an accurate real-time assessment and precise measurements of tumor volumes. Spreading of contrast agent-containing blood vessels around and within the tumors was clearly visible over time. Furthermore, fpVCT permits the identification of differences in the uptake of contrast media within tumors, thus delineating necrosis, tumor tissues, and blood vessels. Classification of tumor tissues based on the decomposition of the underlying mixture distribution of tissue-related Hounsfield units allowed the quantitative acquisition of necrotic tissues at each time point. Morphologic alterations of the tumor depicted by fpVCT were confirmed by histopathologic examination. Concluding, our data show that fpVCT may be highly suitable for the noninvasive evaluation of tumor responses to anticancer therapies during the course of the disease.

  6. Exponential sums over primes in short intervals

    Institute of Scientific and Technical Information of China (English)

    LIU; Jianya

    2006-01-01

    [1]Vinogradov,I.M.,Estimation of certain trigonometric sums with prime variables,Izv.Acad.Nauk.SSSR,1939,3:371-398.[2]Zhan,T.,On the representation of large odd integer as a sum of three almost equal primes,Acta Math.Sin.,1991,7:259-272.[3]Ren,X.M.,On exponential sums over primes and application in the Waring-Goldbach problem,Sci.China,Ser.A-Math.,2005,48(6):785-797.[4]Liu,J.Y.,Wooley,T.D.,Yu,G.,The quadratic Waring-Goldbach problem,J.Number Theory,2004,107:298-321.[5]Hua,L.K.,Some results in the additive prime number theory,Quart.J.Math.(Oxford),1938,9:68-80.[6]Liu,J.Y.,Zhan,T.,On sums of five almost equal prime squares,Acta Arith.,1996,77:369-383.[7]Bauer,C.,A note on sums of five almost equal prime squares,Arch.Math,1997,69:20-30.[8]Liu,J.Y.,Zhan,T.,Sums of five almost equal prime squares,Science in China,Ser.A,1998,41:710-722.[9]Liu,J.Y.,Zhan,T.,Hua's theorem on prime squares in short intervals,Acta Math.Sin.,2000,16:1-22.[10]Bauer,C.,Sums of five almost equal prime squares,Acta Math.Sin.,2005,21(4):833-840.[11]Lü,G.S.,Hua's Theorem with five almost equal prime variables,Chin.Ann.Math.,Ser.B,2005,26(2):291-304.[12]Vinogradov,I.M.,Elements of Number Theory,Dover Publications,1954.[13]Titchmarsh,E.C.,The Theory of the Riemann Zeta-function,2nd ed.,Oxford:Oxford University Press,1986.

  7. Magnetohydrodynamic Boundary Layer Flow of Nanofluid over an Exponentially Stretching Permeable Sheet

    Directory of Open Access Journals (Sweden)

    Krishnendu Bhattacharyya

    2014-01-01

    Full Text Available A mathematical model of the steady boundary layer flow of nanofluid due to an exponentially permeable stretching sheet with external magnetic field is presented. In the model, the effects of Brownian motion and thermophoresis on heat transfer and nanoparticle volume friction are considered. Using shooting technique with fourth-order Runge-Kutta method the transformed equations are solved. The study reveals that the governing parameters, namely, the magnetic parameter, the wall mass transfer parameter, the Prandtl number, the Lewis number, Brownian motion parameter, and thermophoresis parameter, have major effects on the flow field, the heat transfer, and the nanoparticle volume fraction. The magnetic field makes enhancement in temperature and nanoparticle volume fraction, whereas the wall mass transfer through the porous sheet causes reduction of both. For the Brownian motion, the temperature increases and the nanoparticle volume fraction decreases. Heat transfer rate becomes low with increase of Lewis number. For thermophoresis effect, the thermal boundary layer thickness becomes larger.

  8. Volume Change of Heterogeneous Quasi-brittle Materials in Uniaxial Compression

    Institute of Scientific and Technical Information of China (English)

    WANG Xuebin

    2006-01-01

    The volumetric strain was categorized into elastic and plastic parts. The former composed of axial and lateral strains is uniform and determined by Hooke's law; however, the latter consisting of axial and lateral strains is a function of thickness of shear band determined by gradient-dependent plasticity by considering the heterogeneity of quasi-brittle materials. The non-uniform lateral strain due to the fact that shear band was formed in the middle of specimen was averaged within specimen to precisely assess the volumetric strain. Then, the analytical expression for volumetric strain was verified by comparison with two earlier experimental results for concrete and rock. Finally, a detailed parametric study was carried out to investigate effects of constitutive parameters (shear band thickness, elastic and softening moduli) and geometrical size of specimen(height and width of specimen) on the volume dilatancy.

  9. Insufficiencies of the Single Exponential Model and Efficiency of the Double Exponential Model in the Optimization of Solar Cells Efficiency

    OpenAIRE

    A. Zerga; B. Benyoucef; J.-P. Charles

    1998-01-01

    Single and double exponential models are confronted to determine the most adapted model for optimization of solar cells efficiency. It is shown that the single exponential model (SEM) presents some insufficiencies for efficiency optimization. The interest of the double exponential model to optimize the efficiency and to achieve an adequate simulation of the operation of solar cells is demonstrated by means of I-V characteristics plotting.

  10. Composition-volume changes during hydrothermal alteration of andesite at Buttercup Hill, Noranda District, Quebec

    Science.gov (United States)

    Lesher, C. M.; Gibson, H. L.; Campbell, I. H.

    1986-12-01

    hydrothermal modification of the andesite. Mass balance calculations suggest that volume was conserved during epidotization-silicification and albitization-silicification, but that intense silicification was accompanied by volume increases up to 30 percent.

  11. The effect of strain path change on subgrain volume fraction determined from in situ X-ray measurements

    DEFF Research Database (Denmark)

    Wejdemann, Christian; Poulsen, Henning Friis; Lienert, U.

    2009-01-01

    The evolution of dislocation structures in individual bulk grains in copper during strain path changes is studied with a new in situ synchrotron technique which combines high angular resolution with fast three-dimensional reciprocal space mapping. Deformed copper contains regions with vanishing...... dislocation density called subgrains bounded by dislocation rich walls. With the new technique reciprocal space maps, consisting of sharp peaks arising from the subgrains superimposed on a cloud of lower intensity arising from the dislocation walls, are obtained, which allows properties such as subgrain...... volume fraction to be quantified. The studied strain path changes are tension-tension sequences. Polycrystalline copper sheets are pre-deformed in tension to 5% strain, and tensile samples are cut with varying angles between the first and second loading axis. The second tensile deformation up...

  12. Detection of atomic scale changes in the free volume void size of three-dimensional colorectal cancer cell culture using positron annihilation lifetime spectroscopy.

    Science.gov (United States)

    Axpe, Eneko; Lopez-Euba, Tamara; Castellanos-Rubio, Ainara; Merida, David; Garcia, Jose Angel; Plaza-Izurieta, Leticia; Fernandez-Jimenez, Nora; Plazaola, Fernando; Bilbao, Jose Ramon

    2014-01-01

    Positron annihilation lifetime spectroscopy (PALS) provides a direct measurement of the free volume void sizes in polymers and biological systems. This free volume is critical in explaining and understanding physical and mechanical properties of polymers. Moreover, PALS has been recently proposed as a potential tool in detecting cancer at early stages, probing the differences in the subnanometer scale free volume voids between cancerous/healthy skin samples of the same patient. Despite several investigations on free volume in complex cancerous tissues, no positron annihilation studies of living cancer cell cultures have been reported. We demonstrate that PALS can be applied to the study in human living 3D cell cultures. The technique is also capable to detect atomic scale changes in the size of the free volume voids due to the biological responses to TGF-β. PALS may be developed to characterize the effect of different culture conditions in the free volume voids of cells grown in vitro.

  13. Exponential Correlation of IQ and the Wealth of Nations

    Science.gov (United States)

    Dickerson, Richard E.

    2006-01-01

    Plots of mean IQ and per capita real Gross Domestic Product for groups of 81 and 185 nations, as collected by Lynn and Vanhanen, are best fitted by an exponential function of the form: GDP = "a" * 10["b"*(IQ)], where "a" and "b" are empirical constants. Exponential fitting yields markedly higher correlation coefficients than either linear or…

  14. A Learning Cycle on Exponential Growth and the Energy Crises.

    Science.gov (United States)

    Dykstra, D. I., Jr.

    1982-01-01

    Describes nature and logistics of a learning cycle approach to teaching exponential growth and the energy crisis. Used with both science and nonscience majors, the cycle uses no algebra, never mentions the terms exponential or logarithmic, and requires a calculator. Instructions for obtaining student and instructor materials are provided.…

  15. Exponential Shear Flow of Linear, Entangled Polymeric Liquids

    DEFF Research Database (Denmark)

    Neergaard, Jesper; Park, Kyungho; Venerus, David C.

    2000-01-01

    A previously proposed reptation model is used to interpret exponential shear flow data taken on an entangled polystyrenesolution. Both shear and normal stress measurements are made during exponential shear using mechanical means. The model iscapable of explaining all trends seen in the data, and ...

  16. Molecular integrals for exponential-type orbitals using hyperspherical harmonics

    DEFF Research Database (Denmark)

    Avery, James Emil; Avery, John Scales

    2015-01-01

    Exponential-type orbitals are better suited to calculations of molecular electronic structure than are Gaussians, since ETO's can accurately represent the behavior of molecular orbitals near to atomic nuclei, as well as their long-distance exponential decay. Orbitals based on Gaussians fail in bo...

  17. A nomogram for deconvolution of single exponential fluorescence decays.

    OpenAIRE

    Rockley, M.G.

    1980-01-01

    An extremely rapid technique for deconvolving single exponential luminescence decay data is described that involves essentially no mathematical manipulation of the experimental data. The method permits "real time" measurement of deconvolved luminescence lifetimes with conventional pulsed, lifetime-fluorometers and phosphorimeters. The method assumes that the true luminescence decay of the chromophore is accurately represented by a single exponential decay function.

  18. Residual, restarting and Richardson iteration for the matrix exponential

    NARCIS (Netherlands)

    Botchev, M.A.

    2010-01-01

    A well-known problem in computing some matrix functions iteratively is a lack of a clear, commonly accepted residual notion. An important matrix function for which this is the case is the matrix exponential. Assume, the matrix exponential of a given matrix times a given vector has to be computed.

  19. Residual, restarting and Richardson iteration for the matrix exponential

    NARCIS (Netherlands)

    Botchev, Mike A.; Grimm, Volker; Hochbruck, Marlis

    2013-01-01

    A well-known problem in computing some matrix functions iteratively is the lack of a clear, commonly accepted residual notion. An important matrix function for which this is the case is the matrix exponential. Suppose the matrix exponential of a given matrix times a given vector has to be computed.

  20. Exponential Decay of Correlations for the Strongly Coupled Toom Model

    CERN Document Server

    de Maere, Augustin

    2011-01-01

    We prove that, for the two-dimensional probabilistic cellular automaton of Toom in the low-noise regime, there are two classes of initial measures, each of which converges exponentially fast toward one of the two natural invariant measures. We also show that these two invariant measures have exponential decay of correlations in space and in time and are strongly mixing.

  1. Exponential B-splines and the partition of unity property

    DEFF Research Database (Denmark)

    Christensen, Ole; Massopust, Peter

    2012-01-01

    We provide an explicit formula for a large class of exponential B-splines. Also, we characterize the cases where the integer-translates of an exponential B-spline form a partition of unity up to a multiplicative constant. As an application of this result we construct explicitly given pairs of dual...

  2. Review of "Going Exponential: Growing the Charter School Sector's Best"

    Science.gov (United States)

    Garcia, David

    2011-01-01

    This Progressive Policy Institute report argues that charter schools should be expanded rapidly and exponentially. Citing exponential growth organizations, such as Starbucks and Apple, as well as the rapid growth of molds, viruses and cancers, the report advocates for similar growth models for charter schools. However, there is no explanation of…

  3. Effects of Hormone Therapy on Brain Volumes Changes of Postmenopausal Women Revealed by Optimally-Discriminative Voxel-Based Morphometry.

    Directory of Open Access Journals (Sweden)

    Tianhao Zhang

    Full Text Available The Women's Health Initiative Memory Study Magnetic Resonance Imaging (WHIMS-MRI provides an opportunity to evaluate how menopausal hormone therapy (HT affects the structure of older women's brains. Our earlier work based on region of interest (ROI analysis demonstrated potential structural changes underlying adverse effects of HT on cognition. However, the ROI-based analysis is limited in statistical power and precision, and cannot provide fine-grained mapping of whole-brain changes.We aimed to identify local structural differences between HT and placebo groups from WHIMS-MRI in a whole-brain refined level, by using a novel method, named Optimally-Discriminative Voxel-Based Analysis (ODVBA. ODVBA is a recently proposed imaging pattern analysis approach for group comparisons utilizing a spatially adaptive analysis scheme to accurately locate areas of group differences, thereby providing superior sensitivity and specificity to detect the structural brain changes over conventional methods.Women assigned to HT treatments had significant Gray Matter (GM losses compared to the placebo groups in the anterior cingulate and the adjacent medial frontal gyrus, and the orbitofrontal cortex, which persisted after multiple comparison corrections. There were no regions where HT was significantly associated with larger volumes compared to placebo, although a trend of marginal significance was found in the posterior cingulate cortical area. The CEE-Alone and CEE+MPA groups, although compared with different placebo controls, demonstrated similar effects according to the spatial patterns of structural changes.HT had adverse effects on GM volumes and risk for cognitive impairment and dementia in older women. These findings advanced our understanding of the neurobiological underpinnings of HT effects.

  4. Gray matter volume changes in chronic subcortical stroke: A cross-sectional study

    Directory of Open Access Journals (Sweden)

    Qingqing Diao

    2017-01-01

    Full Text Available This study aimed to investigate the effects of lesion side and degree of motor recovery on gray matter volume (GMV difference relative to healthy controls in right-handed subcortical stroke. Structural MRI data were collected in 97 patients with chronic subcortical ischemic stroke and 79 healthy controls. Voxel-wise GMV analysis was used to investigate the effects of lesion side and degree of motor recovery on GMV difference in right-handed chronic subcortical stroke patients. Compared with healthy controls, right-lesion patients demonstrated GMV increase (P < 0.05, voxel-wise false discovery rate correction in the bilateral paracentral lobule (PCL and supplementary motor area (SMA and the right middle occipital gyrus (MOG; while left-lesion patients did not exhibit GMV difference under the same threshold. Patients with complete and partial motor recovery showed similar degree of GMV increase in right-lesion patients. However, the motor recovery was correlated with the GMV increase in the bilateral SMA in right-lesion patients. These findings suggest that there exists a lesion-side effect on GMV difference relative to healthy controls in right-handed patients with chronic subcortical stroke. The GMV increase in the SMA may facilitate motor recovery in subcortical stroke patients.

  5. Safe use of mine winding rope, volume 2: recommendations for changes in rope safety factors.

    CSIR Research Space (South Africa)

    Hecker, GFK

    1996-04-01

    Full Text Available The steering committee on factors of safety of winder ropes has appointed a working group to draw up a set of proposals for changing the regulations governing the required rope strength in the Minerals Act. Certain research projects have been...

  6. Battelle Research Outlook, Volume 2 Number 2. The Schools: Organizing for Change.

    Science.gov (United States)

    Westerman, Arthur B., Ed.

    "Outlook" publications focus on areas of science and technology in which research can be valuable to industry, government, and society as a whole. Their purpose is to point up significant current problems in those areas and to suggest effective research approaches to their solution. This issue, dealing with changes taking place in our schools and…

  7. Tectonics, orbital forcing, global climate change, and human evolution in Africa: introduction to the African paleoclimate special volume.

    Science.gov (United States)

    Maslin, Mark A; Christensen, Beth

    2007-11-01

    The late Cenozoic climate of Africa is a critical component for understanding human evolution. African climate is controlled by major tectonic changes, global climate transitions, and local variations in orbital forcing. We introduce the special African Paleoclimate Issue of the Journal of Human Evolution by providing a background for and synthesis of the latest work relating to the environmental context for human evolution. Records presented in this special issue suggest that the regional tectonics, appearance of C(4) plants in East Africa, and late Cenozoic global cooling combined to produce a long-term drying trend in East Africa. Of particular importance is the uplift associated with the East African Rift Valley formation, which altered wind flow patterns from a more zonal to more meridinal direction. Results in this volume suggest a marked difference in the climate history of southern and eastern Africa, though both are clearly influenced by the major global climate thresholds crossed in the last 3 million years. Papers in this volume present lake, speleothem, and marine paleoclimate records showing that the East African long-term drying trend is punctuated by episodes of short, alternating periods of extreme wetness and aridity. These periods of extreme climate variability are characterized by the precession-forced appearance and disappearance of large, deep lakes in the East African Rift Valley and paralleled by low and high wind-driven dust loads reaching the adjacent ocean basins. Dating of these records show that over the last 3 million years such periods only occur at the times of major global climatic transitions, such as the intensification of Northern Hemisphere Glaciation (2.7-2.5 Ma), intensification of the Walker Circulation (1.9-1.7 Ma), and the Mid-Pleistocene Revolution (1-0.7 Ma). Authors in this volume suggest this onset occurs as high latitude forcing in both Hemispheres compresses the Intertropical Convergence Zone so that East Africa

  8. Temporal changes in integrin-mediated cardiomyocyte adhesion secondary to chronic cardiac volume overload in rats

    Science.gov (United States)

    Stewart, James A.; Gardner, Jason D.; Brower, Gregory L.

    2013-01-01

    Previous studies have established integrins as cell surface receptors that mediate cardiomyocyte-extracellular matrix (ECM) attachments. This study sought to determine the contributions of the myocardial β1- and β3-integrin subunits to ventricular dilatation and coronary flow regulation using a blood-perfused isolated heart preparation. Furthermore, cardiomyocyte adhesion to collagen types I and IV, fibronectin, and laminin with and without a β1-integrin subunit neutralizing antibody was assessed during the course of remodeling secondary to a sustained cardiac volume overload, including the onset of heart failure. Isolated cardiomyocytes were obtained during the initial, compensated, and decompensated phases of remodeling resulting from an aortocaval fistula created in 8-wk-old male Sprague-Dawley rats. Blocking the β1-integrin subunit in isolated normal hearts produced ventricular dilatation, whereas this was not the case when the β3-subunit was blocked. Substantial reductions in cardiomyocyte adhesion coincided with the previously documented development of ventricular dilatation and decreased contractility postfistula, with the β1-integrin contribution to adhesion ranging from 28% to 73% over the course of remodeling being essentially substrate independent. In contrast, both integrin subunits were found to be involved in regulating coronary vascular resistance. It is concluded that marked reductions in integrin-mediated cardiomyocyte adhesion to the ECM play a significant role in the progression of adverse myocardial remodeling that leads to heart failure. Furthermore, although both the β1- and β3-integrin subunits were involved in regulating coronary vascular resistance, only inhibition of β1-integrin-mediated adhesion resulted in ventricular dilatation of the normal heart. PMID:24163072

  9. A consensus-based dynamics for market volumes

    Science.gov (United States)

    Sabatelli, Lorenzo; Richmond, Peter

    2004-12-01

    We develop a model of trading orders based on opinion dynamics. The agents may be thought as the share holders of a major mutual fund rather than as direct traders. The balance between their buy and sell orders determines the size of the fund order (volume) and has an impact on prices and indexes. We assume agents interact simultaneously to each other through a Sznajd-like interaction. Their degree of connection is determined by the probability of changing opinion independently of what their neighbours are doing. We assume that such a probability may change randomly, after each transaction, of an amount proportional to the relative difference between the volatility then measured and a benchmark that we assume to be an exponential moving average of the past volume values. We show how this simple model is compatible with some of the main statistical features observed for the asset volumes in financial markets.

  10. Pulmonary intravascular blood volume changes through the cardiac cycle in healthy volunteers studied by cardiovascular magnetic resonance measurements of arterial and venous flow

    Directory of Open Access Journals (Sweden)

    Arheden Hakan

    2009-10-01

    Full Text Available Abstract Background This study aims to present a novel method for using cardiovascular magnetic resonance (CMR to non-invasively quantify the variation in pulmonary blood volume throughout the cardiac cycle in humans. Methods 10 healthy volunteers (7 males, 3 female, age range 21-32 years were studied. The blood flow in the pulmonary artery and all pulmonary veins was quantified during free breathing using phase contrast velocity encoded CMR. The difference in flow between the pulmonary artery and the pulmonary veins was integrated to calculate the change in pulmonary blood volume throughout the cardiac cycle. Results The stroke volumes in the pulmonary artery and the sum of the pulmonary veins were (mean ± SEM 103 ± 6 ml and 95 ± 6 ml, respectively. The pulmonary blood volume variation (PBVV was 48 ± 5 ml, and the PBVV expressed as percent of the pulmonary artery stroke volume was 46 ± 3%. The maximum increase in pulmonary blood volume occurred 310 ± 12 ms after the R-wave from the ECG (32 ± 2% of the cardiac cycle. PBVV did not correlate to change in cross-sectional area in the pulmonary artery (R2 = 0.03, p = 0.66. Conclusion It is feasible to non-invasively quantify the change in pulmonary blood volume during the cardiac cycle in humans using CMR. The average pulmonary blood volume variation in healthy volunteers was approximately 50 ml and this was approximately 50% of the stroke volume. Further studies are needed to assess the utility of the pulmonary blood volume variation as a measure for identifying cardiac and pulmonary vascular disease.

  11. Iodine fortification may influence the age-related change in thyroid volume

    DEFF Research Database (Denmark)

    Motavaf, Anne Krejbjerg; Pedersen, Inge Bülow; Bjergved, Lena

    2014-01-01

    , increased series-resistance losses, and potential-induced degradation of the PV generator by analysing changes its current-voltage characteristic curve. The diagnostic method is based on parameters that can be easily calculated from the shape of the current-voltage curve, making it machine-analysis friendly...... and analysis of the diagnostic parameters and logic was performed based on module level tests on standard crystalline silicon PV modules, and were optimized to detect even small partial shading and increase series-resistance losses. To demonstrate the practical application and operation of this method...

  12. Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression

    DEFF Research Database (Denmark)

    Jørgensen, A.; Magnusson, P.; Hanson, Lars G.

    2016-01-01

    , and metabolite changes in 19 patients receiving ECT for severe depression. Other regions of interest included the amygdala, dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex, and hypothalamus. Patients received a 3T MR scan before ECT (TP1), 1 week (TP2), and 4 weeks (TP3) after ECT. Results......, and we were unable to identify a spectral signature at 1.30 ppm previously suggested to reflect neurogenesis induced by ECT. None of the brain imaging measures correlated to the clinical response. Conclusion: Our findings show that ECT causes a remodeling of brain structures involved in affective...

  13. Comparison of grey matter volume and thickness for analysing cortical changes in chronic schizophrenia: a matter of surface area, grey/white matter intensity contrast, and curvature.

    Science.gov (United States)

    Kong, Li; Herold, Christina J; Zöllner, Frank; Salat, David H; Lässer, Marc M; Schmid, Lena A; Fellhauer, Iven; Thomann, Philipp A; Essig, Marco; Schad, Lothar R; Erickson, Kirk I; Schröder, Johannes

    2015-02-28

    Grey matter volume and cortical thickness are the two most widely used measures for detecting grey matter morphometric changes in various diseases such as schizophrenia. However, these two measures only share partial overlapping regions in identifying morphometric changes. Few studies have investigated the contributions of the potential factors to the differences of grey matter volume and cortical thickness. To investigate this question, 3T magnetic resonance images from 22 patients with schizophrenia and 20 well-matched healthy controls were chosen for analyses. Grey matter volume and cortical thickness were measured by VBM and Freesurfer. Grey matter volume results were then rendered onto the surface template of Freesurfer to compare the differences from cortical thickness in anatomical locations. Discrepancy regions of the grey matter volume and thickness where grey matter volume significantly decreased but without corresponding evidence of cortical thinning involved the rostral middle frontal, precentral, lateral occipital and superior frontal gyri. Subsequent region-of-interest analysis demonstrated that changes in surface area, grey/white matter intensity contrast and curvature accounted for the discrepancies. Our results suggest that the differences between grey matter volume and thickness could be jointly driven by surface area, grey/white matter intensity contrast and curvature.

  14. Regulation of cloned, Ca2+-activated K+ channels by cell volume changes

    DEFF Research Database (Denmark)

    Grunnet, Morten; MacAulay, Nanna; Jorgensen, Nanna K;

    2002-01-01

    Ca2+-activated K+ channels of big (hBK), intermediate (hIK) or small (rSK3) conductance were co-expressed with aquaporin 1 (AQP1) in Xenopus laevis oocytes. hBK channels were activated by depolarization, whereas hIK and rSK3 channels were activated by direct injection of Ca2+ or Cd2+ into the ooc......Ca2+-activated K+ channels of big (hBK), intermediate (hIK) or small (rSK3) conductance were co-expressed with aquaporin 1 (AQP1) in Xenopus laevis oocytes. hBK channels were activated by depolarization, whereas hIK and rSK3 channels were activated by direct injection of Ca2+ or Cd2......+ into the oocyte cytoplasm, before the oocytes were subjected to hyperosmolar or hypoosmolar (+/-50 mOsm mannitol) challenges. In all cases, the oocytes responded rapidly to the osmotic changes with shrinkage or swelling and the effects on the K+ currents were measured. hIK and rSK3 currents were highly sensitive......IK/rSK3 and hBK channels suggest that the significant stimulation of hIK and rSK3 channels during swelling is not mediated by changes in intracellular Ca2+, but rather through interactions with the cytoskeleton, provided that a sufficient basal concentration of intracellular Ca2+ or Cd2+ is present....

  15. Changing times. Southwest Energy-Minerals Conference Proceedings, Volumes 1 and 2

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-01-01

    This conference was held at the Albuquerque Convention Center, Albuquerque, NM, Nov. 2 and 3, 1977. It was sponsored by the Bureau of Land Management, U.S. Dept. of the Interior. It contains articles on the leasing of coal deposits (changes and modifications of leasing policy, environmental impact statements, U.S. energy policy (NEP), prices of gas and oil), New Mexico's energy consumption (by the Governor), transport of energy (Santa Fe railroad's plans), the energy crisis and proposed solutions, energy supplies and environmental problems, energy problems of agriculture (fuels, fertilizers and water energy requirements are greater than the energy in the food produced; possibility of biomass conversion, photosynthetic efficiency of using sunlight in arid lands), energy project financing, a review of the recent Law of the Sea conferences (1967 to date) (mining projects), growth economy as no growth and relation to energy supplies and environmental problems, natural gas and petroleum industries (divestiture problems, reserves), raw materials stockpiles (national experience, changing targets), the mining industry and its reserves of metals, taxation, etc.). (LTN)

  16. Turn down the volume or change the channel? Emotional effects of detached versus positive reappraisal.

    Science.gov (United States)

    Shiota, Michelle N; Levenson, Robert W

    2012-09-01

    Cognitive reappraisal, or changing one's interpretation of an event in order to alter the emotional response to it, is thought to be a healthy and an effective emotion regulation strategy. Although researchers recognize several distinct varieties of reappraisal, few studies have explicitly compared the effects of multiple reappraisal strategies on emotional responding. The present study compares the effects of detached and positive reappraisal on thought content, subjective emotional experience, physiological reactivity, and facial expressions of emotion while viewing film clips evoking sadness and disgust. Although both forms of reappraisal reduced overall emotional responding to unpleasant stimuli, the effects of detached reappraisal were stronger in this regard, and positive reappraisal was more likely to maintain subjective experience and facial expression of stimulus-appropriate positive emotions. The two reappraisal strategies also produced somewhat different profiles of physiological responding. Differences between detached and positive reappraisal with respect to subjective experience and facial expression were more pronounced among men than women; the reverse was true for differences with respect to physiological responding. Beyond these effects on individual emotion response systems, detached and positive reappraisal also had somewhat different effects on coherence in change across response systems. Implications for our understanding of emotion regulation processes, and for emotion theory more broadly, are discussed.

  17. Turn Down the Volume or Change the Channel?: Emotional Effects of Detached Versus Positive Reappraisal

    Science.gov (United States)

    Shiota, Michelle N.; Levenson, Robert W.

    2013-01-01

    Cognitive reappraisal, or changing one’s interpretation of an event in order to alter the emotional response to it, is thought to be a healthy and effective emotion regulation strategy. Although researchers recognize several distinct varieties of reappraisal, few studies have explicitly compared the effects of multiple reappraisal strategies on emotional responding. The present study compares the effects of detached and positive reappraisal on thought content, subjective emotional experience, physiological reactivity, and facial expressions of emotion while viewing film clips evoking sadness and disgust. While both forms of reappraisal reduced overall emotional responding to unpleasant stimuli, the effects of detached reappraisal were stronger in this regard, and positive reappraisal was more likely to maintain subjective experience and facial expression of stimulus-appropriate positive emotions. The two reappraisal strategies also produced somewhat different profiles of physiological responding. Differences between detached and positive reappraisal with respect to subjective experience and facial expression were more pronounced among men than women; the reverse was true for differences with respect to physiological responding. Beyond these effects on individual emotion response systems, detached and positive reappraisal also had somewhat different effects on coherence in change across response systems. Implications for our understanding of emotion regulation processes, and for emotion theory more broadly, are discussed. PMID:22746676

  18. Glacier length, area and volume changes in the Himalaya: an overview and specific examples

    Science.gov (United States)

    Bolch, T.; Bhambri, R.; Kamp, U.; Pieczonka, T.

    2011-12-01

    The Himalaya comprises one of the largest glacier-covered areas outside the polar regions. Glaciers are of special interest for several reasons. For instance, receding glaciers can cause the development of hazardous glacial lakes and glaciers contribute to the overall river runoff. The importance of the glacier melt to run off, however, varies significantly depending especially on the precipitation regime. Previous studies indicate that the vast majority of the Himalayan glaciers retreated during the recent decades with only few exemptions. Although the numbers of investigates glaciers increased in the last few years, there is still a lack of knowledge about the glacier behaviour in the different regions of the Himalaya. Existing length measurements in the Indian Himalaya show continuous retreat with an accelerating trend in recent years for most of the glaciers. The annual retreat rates vary between ~5m and more than 50m. However, several measurements are based on topographic maps or coarse satellite data and can have therefore higher uncertainties. Own reassessments for the debris-covered Gangotri Glacier situated in Garhwal Himalaya/western India based on high resolution imagery such as Corona, Hexagon, IRS PAN, LISS IV, and Cartosat-1 show an continuous retreat with an average rate of 19.9 ± 0.3 m a-1 from 1965 to 2006. This is significant but less than previously published. Similar results were revealed for the area changes in upper Alaknanda and Bhagirathi valleys in Garhwal Himalaya. We found a lower but still significant area loss of 4.6 ± 2.8 % between 1968 and 2006. Area changes in Khumbu Himalaya/Nepal are with ~5% between 1962 and 2005 comparable. Investigations in the Greater Himalayan Range in southern Ladakh/northwest India revealed a general receding trend but with some of the larger glaciers with high altitude catchments being stable or even advancing. Preliminary results for Shyok Valley (Jammu and Kashmir) show on average stable or slightly

  19. Three-dimensional flow of nanofluid induced by an exponentially stretching sheet: an application to solar energy.

    Directory of Open Access Journals (Sweden)

    Junaid Ahmad Khan

    Full Text Available This work deals with the three-dimensional flow of nanofluid over a bi-directional exponentially stretching sheet. The effects of Brownian motion and thermophoretic diffusion of nanoparticles are considered in the mathematical model. The temperature and nanoparticle volume fraction at the sheet are also distributed exponentially. Local similarity solutions are obtained by an implicit finite difference scheme known as Keller-box method. The results are compared with the existing studies in some limiting cases and found in good agreement. The results reveal the existence of interesting Sparrow-Gregg-type hills for temperature distribution corresponding to some range of parametric values.

  20. Three-Dimensional Flow of Nanofluid Induced by an Exponentially Stretching Sheet: An Application to Solar Energy

    Science.gov (United States)

    Khan, Junaid Ahmad; Mustafa, M.; Hayat, T.; Sheikholeslami, M.; Alsaedi, A.

    2015-01-01

    This work deals with the three-dimensional flow of nanofluid over a bi-directional exponentially stretching sheet. The effects of Brownian motion and thermophoretic diffusion of nanoparticles are considered in the mathematical model. The temperature and nanoparticle volume fraction at the sheet are also distributed exponentially. Local similarity solutions are obtained by an implicit finite difference scheme known as Keller-box method. The results are compared with the existing studies in some limiting cases and found in good agreement. The results reveal the existence of interesting Sparrow-Gregg-type hills for temperature distribution corresponding to some range of parametric values. PMID:25785857

  1. Effect of change in blood volume in skin plus active muscle on heart rate drift during submaximal exercise.

    Science.gov (United States)

    Yano, T; Yunoki, T; Matsuura, R; Arimitsu, T; Kimura, T

    2008-12-01

    The purpose of the present study was to examine the effect of change in blood volume in skin plus active muscle on heart rate drift during moderate exercise and heavy exercise for 30 min. Total hemoglobin concentration (Total Hb) in the vastus lateralis muscle plus its skin was determined by near-infrared spectroscopy. Total Hb significantly increased and remained stable from 20 min in moderate exercise and from 10 min in heavy exercise. Heart rate (HR) rapidly increased until 3 min and showed a steady state in moderate exercise. HR at 30 min was significantly higher than that at 3 min in moderate exercise. HR rapidly increased until 3 min and then gradually but significantly increased in heavy exercise. Increase in total Hb was not significantly related with HR after 3 min of exercise when HR was around 120 beats per min in moderate exercise. Increase in total Hb was significantly related with HR from 3 min to 10 min in the heavy exercise (correlation coefficients ranged from 0.959 to 0.702). It is concluded that an increase in the blood volume in skin plus active muscle is not simply associated with HR drift.

  2. Usefulness of Intravital Multiphoton Microscopy in Visualizing Study of Mouse Cochlea and Volume Changes in the Scala Media

    Directory of Open Access Journals (Sweden)

    Hyun Mi Ju

    2017-07-01

    Full Text Available Conventional microscopy has limitations in viewing the cochlear microstructures due to three-dimensional spiral structure and the overlying bone. But these issues can be overcome by imaging the cochlea in vitro with intravital multiphoton microscopy (MPM. By using near-infrared lasers for multiphoton excitation, intravital MPM can detect endogenous fluorescence and second harmonic generation of tissues. In this study, we used intravital MPM to visualize various cochlear microstructures without any staining and non-invasively analyze the volume changes of the scala media (SM without removing the overlying cochlear bone. The intravital MPM images revealed various tissue types, ranging from thin membranes to dense bone, as well as the spiral ganglion beneath the cochlear bone. The two-dimensional, cross-sectional, and serial z-stack intravital MPM images also revealed the spatial dilation of the SM in the temporal bone of pendrin-deficient mice. These findings suggest that intravital MPM might serve as a new method for obtaining microanatomical information regarding the cochlea, similar to standard histopathological analyses in the animal study for the cochlea. Given the capability of intravital MPM for detecting an increase in the volume of the SM in pendrin-deficient mice, it might be a promising new tool for assessing the pathophysiology of hearing loss in the future.

  3. RELATIONSHIP BETWEEN TRAINING VOLUME AND BONE MINERAL DENSITY CHANGES IN ELDERLY WOMEN

    Directory of Open Access Journals (Sweden)

    Juan José Rábade Espinosa

    Full Text Available ABSTRACT Introduction: Several studies have analyzed the relationship between physical activity and bone density. However, the prescription of exercise is not entirely clear as to the type, quantity and intensity. Objective: The objective of this study was to determine if there is a relationship between the amount of exercise and changes in bone mineral density. Methods: Fifty-two women, members of the Municipal Program of Physical Activity for Seniors, voluntarily underwent two ultrasonographies of the calcaneus within a 6-month interval. During this period, all physical activity was recorded. Afterwards, a lineal correlation study was carried out between the amount of exercise and bone changes, expressed as T-Score variation, first in total number of participants and then in groups. Considering the average body weight obtained for all women, two groups were created ("light" 69 kg. Later, women who had participated in less than 72% of the targeted program were excluded from both groups, and the differences between the groups "light and trained" and "heavy and trained" were analyzed. To do so, the nonparametric Mann-Whitney U test was used. Results: A significant relationship of r= -0.59 was found between the total amount of exercise and the T-Score variation in the group of women above 69 kg. Significant differences were found between the "light and trained" group and the "heavy and trained" group with respect to the variation of T-Score. Conclusion: The effect of exercise on bone mineral density is determined, somehow, by body weight. This interaction is due, possibly, to mechanical demands difference.

  4. Laminar phase flow for an exponentially tapered Josephson oscillator

    DEFF Research Database (Denmark)

    Benabdallah, A.; Caputo, J. G.; Scott, Alwyn C.

    2000-01-01

    Exponential tapering and inhomogeneous current feed were recently proposed as means to improve the performance of a Josephson flux flow oscillator. Extensive numerical results backed up by analysis are presented here that support this claim and demonstrate that exponential tapering reduces...... the small current instability region and leads to a laminar flow regime where the voltage wave form is periodic giving the oscillator minimal spectral width. Tapering also leads to an increased output power. Since exponential tapering is not expected to increase the difficulty of fabricating a flux flow...

  5. A modified exponential model for reported death toll during earthquakes

    Institute of Scientific and Technical Information of China (English)

    Xinyan Wu; Jianhua Gu

    2009-01-01

    Reliable earthquake death toll estimate can provide valuable references for disaster relief headquarters and civil administration departments to make arrangement and deployment plan during post-earthquake relief work, thus increasing the efficiency of the relief work to a certain extent. In this study, we acquired the death toll data of Wenchuan earthquake, fitted the data using modified exponential curve and compared the result with that of the exponential function. Experimental verification with Chi-Chi earthquake and Kobe earthquake data shows that the fitted result by modified exponential curve is more satisfactory. The final death toll resulting from future destructive earthquakes can be estimated by the acquired fitting function.

  6. Three-dimensional volume rendering of tibiofibular joint space and quantitative analysis of change in volume due to tibiofibular syndesmosis diastases

    Energy Technology Data Exchange (ETDEWEB)

    Taser, F.; Shafiq, Q.; Ebraheim, N.A. [Medical University of Ohio, Orthopaedic Surgery Department, Toledo, OH (United States)

    2006-12-15

    The diagnosis of ankle syndesmosis injuries is made by various imaging techniques. The present study was undertaken to examine whether the three-dimensional reconstruction of axial CT images and calculation of the volume of tibiofibular joint space enhances the sensitivity of diastases diagnoses or not. Six adult cadaveric ankle specimens were used for spiral CT-scan assessment of tibiofibular syndesmosis. After the specimens were dissected, external fixation was performed and diastases of 1, 2, and 3 mm was simulated by a precalibrated device. Helical CT scans were obtained with 1.0-mm slice thickness. The data was transferred to the computer software AcquariusNET. Then the contours of the tibiofibular syndesmosis joint space were outlined on each axial CT slice and the collection of these slices were stacked using the computer software AutoCAD 2005, according to the spatial arrangement and geometrical coordinates between each slice, to produce a three-dimensional reconstruction of the joint space. The area of each slice and the volume of the entire tibiofibular joint space were calculated. The tibiofibular joint space at the 10th-mm slice level was also measured on axial CT scan images at normal, 1, 2 and 3-mm joint space diastases. The three-dimensional volume-rendering of the tibiofibular syndesmosis joint space from the spiral CT data demonstrated the shape of the joint space and has been found to be a sensitive method for calculating joint space volume. We found that, from normal to 1 mm, a 1-mm diastasis increases approximately 43% of the joint space volume, while from 1 to 3 mm, there is about a 20% increase for each 1-mm increase. Volume calculation using this method can be performed in cases of syndesmotic instability after ankle injuries and for preoperative and postoperative evaluation of the integrity of the tibiofibular syndesmosis. (orig.)

  7. Magnetostructural martensitic transformations with large volume changes and magneto-strains in all-d-metal Heusler alloys

    Energy Technology Data Exchange (ETDEWEB)

    Wei, Z. Y.; Liu, E. K., E-mail: ekliu@iphy.ac.cn; Xi, X. K.; Zhang, H. W.; Wang, W. H.; Wu, G. H. [State Key Laboratory for Magnetism, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China); Li, Y. [State Key Laboratory for Magnetism, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China); School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130 (China); Han, X. L.; Du, Z. W. [National Center of Analysis and Testing for Nonferrous Metals and Electronic Materials, General Research Institute for Nonferrous Metals, Beijing 100088 (China); Luo, H. Z.; Liu, G. D. [School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130 (China)

    2016-08-15

    The all-d-metal Mn{sub 2}-based Heusler ferromagnetic shape memory alloys Mn{sub 50}Ni{sub 40−x}Co{sub x}Ti{sub 10} (x = 8 and 9.5) are realized. With a generic comparison between d-metal Ti and main-group elements in lowering the transformation temperature, the magnetostructural martensitic transformations are established by further introducing Co to produce local ferromagnetic Mn-Co-Mn configurations. A 5-fold modulation and (3, −2) stacking of [00 10] of martensite are determined by X-ray diffraction and HRTEM analysis. Based on the transformation, a large magneto-strain of 6900 ppm and a large volume change of −2.54% are observed in polycrystalline samples, which makes the all-d-metal magnetic martensitic alloys of interest for magnetic/pressure multi-field driven applications.

  8. Assessing high altitude glacier thickness, volume and area changes using field, GIS and remote sensing techniques: the case of Nevado Coropuna (Peru

    Directory of Open Access Journals (Sweden)

    P. Peduzzi

    2010-08-01

    Full Text Available Higher temperatures and changes in precipitation patterns have induced an acute decrease in Andean glaciers, thus leading to additional stress on water supply. To adapt to climate changes, local governments need information on the rate of glacier area and volume losses and on current ice thickness. Remote sensing analyses of Coropuna glacier (Peru delineate an acute glaciated area decline between 1955 and 2008. We tested how volume changes can be estimated with remote sensing and GIS techniques using digital elevation models derived from both topographic maps and satellite images. Ice thickness was measured in 2004 using a Ground Penetrating Radar coupled with a Ground Positioning System during a field expedition. It provided profiles of ice thickness on different slopes, orientations and altitudes. These were used to model the current glacier volume using Geographical Information System and statistical multiple regression techniques. The results revealed a significant glacier volume loss; however the uncertainty is higher than the measured volume loss. We also provided an estimate of the remaining volume. The field study provided the scientific evidence needed by COPASA, a local Peruvian NGO, and GTZ, the German international cooperation agency, in order to alert local governments and communities and guide them in adopting new climate change adaptation policies.

  9. Relation between the Change in Mean Platelet Volume and Clopidogrel Resistance in Patients Undergoing Percutaneous Coronary Intervention.

    Science.gov (United States)

    Koh, Young-Youp; Kim, Hyung Ho; Choi, Dong-Hyun; Lee, Young-Min; Ki, Young-Jae; Kang, Seong-Ho; Park, Geon; Chung, Joong-Wha; Chang, Kyong-Sig; Hong, Soon-Pyo

    2015-01-01

    We aimed to determine the association between the change in mean platelet volume (MPV) over time and aspirin/ clopidogrel resistance in patients undergoing percutaneous coronary intervention (PCI). The MPV and platelet function were analysed in 302 patients who underwent PCI. MPV changes were associated with increased aspirin reaction units (ARU, r = 0.114; P = 0.047), increased P2Y12 reaction units (PRU, r = 0.193; P = 0.001), and decreased P2Y12% inhibition (PI%, r = - 0.273; P resistant group (≥235 PRU or ≤15% of PI%) showed a significantly higher positive change in MPV (ΔMPV) values than the clopidogrel responder group (0.53 ± 0.78 vs. 0.13 ± 0.69 fL, P resistant and responder groups were 72.6% and 59.3%, respectively. After adjusting for traditional risk factors, the odds ratio in the clopidogrel resistant group with ΔMPV ≥0.2 fL was 4.10 (95% confidence interval; 1.84-9.17). In conclusion, ΔMPV was associated with PRU and PI%; a positive ΔMPV was an independent predictive marker for clopidogrel resistance after PCI.

  10. Arterial pressure allows monitoring the changes in cardiac output induced by volume expansion but not by norepinephrine.

    Science.gov (United States)

    Monnet, Xavier; Letierce, Alexia; Hamzaoui, Olfa; Chemla, Denis; Anguel, Nadia; Osman, David; Richard, Christian; Teboul, Jean-Louis

    2011-06-01

    To evaluate to which extent the systemic arterial pulse pressure could be used as a surrogate of cardiac output for assessing the effects of a fluid challenge and of norepinephrine. Observational study. Medical intensive care unit. Patients with an acute circulatory failure who received a fluid challenge (228 patients, group 1) or in whom norepinephrine was introduced or increased (145 patients, group 2). We measured the systolic, diastolic, and mean arterial pressure, pulse pressure, and the transpulmonary thermodilution cardiac output before and after the therapeutic interventions. In group 1, the fluid challenge significantly increased cardiac output by 24% ± 25%. It significantly increased cardiac output by ≥15% (+35% ± 27%) in 142 patients ("responders"). The fluid-induced changes in cardiac output were correlated with the changes in pulse pressure (r = .56, p arterial pressure (r = .55, p arterial pressure (r = .37, p arterial pressure (r = .52, p pressure were significantly related to changes in stroke volume (multiple r = .52) and to age (r = .12). A fluid-induced increase in pulse pressure of ≥17% allowed detecting a fluid-induced increase in cardiac output of ≥15% with a sensitivity of 65[56-72]% and a specificity of 85[76-92]%. The area under the receiver operating characteristic curves for the fluid-induced changes in mean arterial pressure and in diastolic arterial pressure was significantly lower than for pulse pressure. In group 2, the introduction/increase of norepinephrine significantly increased cardiac output by 14% ± 18%. The changes in cardiac output induced by the introduction/increase in the dose of norepinephrine were correlated with the changes in pulse pressure and systolic arterial pressure (r = .21 and .29, respectively, p = .001) but to a significantly lesser extent than in group 1. Pulse pressure and systolic arterial pressure could be used for detecting the fluid-induced changes in cardiac output, in spite of a significant

  11. Repeated Structural Imaging Reveals Nonlinear Progression of Experience-Dependent Volume Changes in Human Motor Cortex.

    Science.gov (United States)

    Wenger, Elisabeth; Kühn, Simone; Verrel, Julius; Mårtensson, Johan; Bodammer, Nils Christian; Lindenberger, Ulman; Lövdén, Martin

    2017-05-01

    Evidence for experience-dependent structural brain change in adult humans is accumulating. However, its time course is not well understood, as intervention studies typically consist of only 2 imaging sessions (before vs. after training). We acquired up to 18 structural magnetic resonance images over a 7-week period while 15 right-handed participants practiced left-hand writing and drawing. After 4 weeks, we observed increases in gray matter of both left and right primary motor cortices relative to a control group; 3 weeks later, these differences were no longer reliable. Time-series analyses revealed that gray matter in the primary motor cortices expanded during the first 4 weeks and then partially renormalized, in particular in the right hemisphere, despite continued practice and increasing task proficiency. Similar patterns of expansion followed by partial renormalization are also found in synaptogenesis, cortical map plasticity, and maturation, and may qualify as a general principle of structural plasticity. Research on human brain plasticity needs to encompass more than 2 measurement occasions to capture expansion and potential renormalization processes over time. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  12. Effect of suction change on water content and total volume of an expansive clay

    Institute of Scientific and Technical Information of China (English)

    ZHAN Liang-tong; CHEN Ping; NG C.W.W.

    2007-01-01

    A laboratory study was carried out on both natural and compacted specimens to investigate the complex soil-water interaction in an unsaturated expansive clay. The laboratory study includes the measurement of soil-water characteristic curves, 1D free swelling tests, measurement of swelling pressure and shrinkage tests. The test results revealed that the air-entry value of the natural specimen was quite low due to cracks and fissures present. The hydraulic hysteresis of the natural specimen was relatively insignificant as compared with the compacted specimen. Within a suction range 0 to 500 kPa, a bilinear relationship between free swelling strain (or swelling pressure) and initial soil suction was observed for both the natural and compacted specimens. As a result of over-consolidation and secondary structures such as cementation and cracks, the natural specimens exhibited significant lower swelling (or swelling pressure) than the compacted specimen. The change of matric suction exerts a more significant effect on the water phase than on the soil skeleton for this expansive clay.

  13. Iodine fortification may influence the age-related change in thyroid volume

    DEFF Research Database (Denmark)

    Motavaf, Anne Krejbjerg; Pedersen, Inge Bülow; Bjergved, Lena

    2014-01-01

    Improving PV system reliability and reducing maintenance and operating costs have become important factors in increasing the competitiveness of PV. Addressing these issues requires diagnostic methods that can detect and identify the occurrence and cause of power loss in the PV system, be it exter......Improving PV system reliability and reducing maintenance and operating costs have become important factors in increasing the competitiveness of PV. Addressing these issues requires diagnostic methods that can detect and identify the occurrence and cause of power loss in the PV system......, be it external, such as shading or soiling, or degradation or failure of the PV modules and balance-of-system components. This allows for performing preventive and/or reparative maintenance, thus minimizing further losses and costs. This article proposes a complete diagnostic method for detecting shading......, increased series-resistance losses, and potential-induced degradation of the PV generator by analysing changes its current-voltage characteristic curve. The diagnostic method is based on parameters that can be easily calculated from the shape of the current-voltage curve, making it machine-analysis friendly...

  14. Unsteady MHD radiative flow and heat transfer of a dusty nanofluid over an exponentially stretching surface

    Directory of Open Access Journals (Sweden)

    N. Sandeep

    2016-03-01

    Full Text Available We analyzed the unsteady magnetohydrodynamic radiative flow and heat transfer characteristics of a dusty nanofluid over an exponentially permeable stretching surface in presence of volume fraction of dust and nano particles. We considered two types of nanofluids namely Cu-water and CuO-water embedded with conducting dust particles. The governing equations are transformed into nonlinear ordinary differential equations by using similarity transformation and solved numerically using Runge–Kutta based shooting technique. The effects of non-dimensional governing parameters namely magneticfield parameter, mass concentration of dust particles, fluid particle interaction parameter, volume fraction of dust particles, volume fraction of nano particles, unsteadiness parameter, exponential parameter, radiation parameter and suction/injection parameter on velocity profiles for fluid phase, dust phase and temperature profiles are discussed and presented through graphs. Also, friction factor and Nusselt numbers are discussed and presented for two dusty nanofluids separately. Comparisons of the present study were made with existing studies under some special assumptions. The present results have an excellent agreement with existing studies. Results indicated that the enhancement in fluid particle interaction increases the heat transfer rate and depreciates the wall friction. Also, radiation parameter has the tendency to increase the temperature profiles of the dusty nanofluid.

  15. On the role of exponential splines in image interpolation.

    Science.gov (United States)

    Kirshner, Hagai; Porat, Moshe

    2009-10-01

    A Sobolev reproducing-kernel Hilbert space approach to image interpolation is introduced. The underlying kernels are exponential functions and are related to stochastic autoregressive image modeling. The corresponding image interpolants can be implemented effectively using compactly-supported exponential B-splines. A tight l(2) upper-bound on the interpolation error is then derived, suggesting that the proposed exponential functions are optimal in this regard. Experimental results indicate that the proposed interpolation approach with properly-tuned, signal-dependent weights outperforms currently available polynomial B-spline models of comparable order. Furthermore, a unified approach to image interpolation by ideal and nonideal sampling procedures is derived, suggesting that the proposed exponential kernels may have a significant role in image modeling as well. Our conclusion is that the proposed Sobolev-based approach could be instrumental and a preferred alternative in many interpolation tasks.

  16. Effects of Exponential Trends on Correlations of Stock Markets

    Directory of Open Access Journals (Sweden)

    Ai-Jing Lin

    2014-01-01

    Full Text Available Detrended fluctuation analysis (DFA is a scaling analysis method used to estimate long-range power-law correlation exponents in time series. In this paper, DFA is employed to discuss the long-range correlations of stock market. The effects of exponential trends on correlations of Hang Seng Index (HSI are investigated with emphasis. We find that the long-range correlations and the positions of the crossovers of lower order DFA appear to have no immunity to the additive exponential trends. Further, our analysis suggests that an increase in the DFA order increases the efficiency of eliminating on exponential trends. In addition, the empirical study shows that the correlations and crossovers are associated with DFA order and magnitude of exponential trends.

  17. Asymptotic expansions of Feynman integrals of exponentials with polynomial exponent

    Science.gov (United States)

    Kravtseva, A. K.; Smolyanov, O. G.; Shavgulidze, E. T.

    2016-10-01

    In the paper, an asymptotic expansion of path integrals of functionals having exponential form with polynomials in the exponent is constructed. The definition of the path integral in the sense of analytic continuation is considered.

  18. Exponential Stability of Stochastic Nonlinear Dynamical Price System with Delay

    Directory of Open Access Journals (Sweden)

    Wenli Zhu

    2013-01-01

    Full Text Available Based on Lyapunov stability theory, Itô formula, stochastic analysis, and matrix theory, we study the exponential stability of the stochastic nonlinear dynamical price system. Using Taylor's theorem, the stochastic nonlinear system with delay is reduced to an n-dimensional semilinear stochastic differential equation with delay. Some sufficient conditions of exponential stability and corollaries for such price system are established by virtue of Lyapunov function. The time delay upper limit is solved by using our theoretical results when the system is exponentially stable. Our theoretical results show that if the classical price Rayleigh equation is exponentially stable, so is its perturbed system with delay provided that both the time delay and the intensity of perturbations are small enough. Two examples are presented to illustrate our results.

  19. Super-Exponential Solution for a Retrial Supermarket Model

    CERN Document Server

    Li, Quan-Lin; Wang, Yang

    2011-01-01

    In this paper, we provide a new and effective approach for studying super-exponential solution of a retrial supermarket model with Poisson arrivals, exponential service times and exponential retrial times and with two different probing-server numbers. We describe the retrial supermarket model as a system of differential equations by means of density-dependent jump Markov processes, and obtain an iterative algorithm for computing the fixed point of the system of differential equations. Based on the fixed point, we analyze the expected sojourn time that a tagged arriving customer spends in this system, and use numerical examples to indicate different influence of the two probing-server numbers on system performance including the fixed point and the expected sojourn time. Furthermore, we analyze exponential convergence of the current location of the retrial supermarket model to the fixed point, and apply the Kurtz Theorem to study density-dependent jump Markov process given in the retrial supermarket model, whic...

  20. Construction of extended exponential general linear methods 524 ...

    African Journals Online (AJOL)

    Construction of extended exponential general linear methods 524 for solving semi-linear problems. ... Journal Home > Vol 13, No 2 (2014) > ... This paper introduces a new approach for constructing higher order of EEGLM which have become ...

  1. Combinatorial polynomials as moments, Hankel transforms and exponential Riordan arrays

    CERN Document Server

    Barry, Paul

    2011-01-01

    In the case of two combinatorial polynomials, we show that they can exhibited as moments of paramaterized families of orthogonal polynomials, and hence derive their Hankel transforms. Exponential Riordan arrays are the main vehicles used for this.

  2. The true quantum face of the "exponential" decay law

    CERN Document Server

    Urbanowski, K

    2016-01-01

    Results of theoretical studies of the quantum unstable systems caused that there are rather widespread belief that a universal feature od the quantum decay process is the presence of three time regimes of the decay process: the early time (initial) leading to the Quantum Zeno (or Anti Zeno) Effects, "exponential" (or "canonical") described by the decay law of the exponential form, and late time characterized by the decay law having inverse--power law form. Based on the fundamental principles of the quantum theory we give the proof that there is no time interval in which the survival probability (decay law) could be a decreasing function of time of the purely exponential form but even at the "exponential" regime the decay curve is oscillatory modulated with a smaller or a large amplitude of oscillations depending on parameters of the model considered.

  3. True quantum face of the "exponential" decay law

    Science.gov (United States)

    Urbanowski, Krzysztof

    2017-05-01

    Results of theoretical studies of the quantum unstable systems caused that there are rather widespread belief that a universal feature of the quantum decay process is the presence of three time regimes of the decay process: the early time (initial) leading to the Quantum Zeno (or Anti Zeno) Effects, "exponential" (or "canonical") described by the decay law of the exponential form, and late time characterized by the decay law having inverse-power law form. Based on the fundamental principles of the quantum theory we give the proof that there is no time interval in which the survival probability (decay law) could be a decreasing function of time of the purely exponential form but even at the "exponential" regime the decay curve is oscillatory modulated with a smaller or a large amplitude of oscillations depending on parameters of the model considered.

  4. Uniformly Exponential Growth and Mapping Class Groups of Surfaces

    OpenAIRE

    Anderson, J. W.; Aramayona, J.; Shackleton, K.J.

    2005-01-01

    We show that the mapping class group (as well as closely related groups) of an orientable surface with finitely generated fundamental group has uniformly exponential growth. We further demonstrate the uniformly non-amenability of many of these groups.

  5. Boundary value problems for partial differential equations with exponential dichotomies

    Science.gov (United States)

    Laederich, Stephane

    We are extending the notion of exponential dichotomies to partial differential evolution equations on the n-torus. This allows us to give some simple geometric criteria for the existence of solutions to certain nonlinear Dirichlet boundary value problems.

  6. Heterogeneous Highly Parallel Implementation of Matrix Exponentiation Using GPU

    CERN Document Server

    Raja, Chittampally Vasanth; Raghavendra, Prakash S; 10.5121/ijdps.2012.3209

    2012-01-01

    The vision of super computer at every desk can be realized by powerful and highly parallel CPUs or GPUs or APUs. Graphics processors once specialized for the graphics applications only, are now used for the highly computational intensive general purpose applications. Very expensive GFLOPs and TFLOP performance has become very cheap with the GPGPUs. Current work focuses mainly on the highly parallel implementation of Matrix Exponentiation. Matrix Exponentiation is widely used in many areas of scientific community ranging from highly critical flight, CAD simulations to financial, statistical applications. Proposed solution for Matrix Exponentiation uses OpenCL for exploiting the hyper parallelism offered by the many core GPGPUs. It employs many general GPU optimizations and architectural specific optimizations. This experimentation covers the optimizations targeted specific to the Scientific Graphics cards (Tesla-C2050). Heterogeneous Highly Parallel Matrix Exponentiation method has been tested for matrices of ...

  7. Modified Binary Exponential Backoff Algorithm to Minimize Mobiles Communication Time

    Directory of Open Access Journals (Sweden)

    Ibrahim Sayed Ahmad

    2014-02-01

    Full Text Available the field of Wireless Local Area Networks (LANs is expanding rapidly as a result of advances in digital communications, portable computers, and semiconductor technology. The early adopters of this technology have primarily been vertical application that places a premium on the mobility offered by such systems. Binary Exponential Backoff (BEB refers to a collision resolution mechanism used in random access MAC protocols. This algorithm is used in Ethernet (IEEE 802.3 wired LANs. In Ethernet networks, this algorithm is commonly used to schedule retransmissions after collisions. The paper’s goal is to minimize the time transmission cycle of the information between mobiles moving in a Wi-Fi by changing the BEB algorithm. The Protocol CSMA / CA manage access to the radio channel by performing an arbitration based on time. This causes many problems in relation to time transmission between mobiles moving in a cell 802.11. what we have done show that the protocol using CSMA / CA access time believed rapidly when the number of stations and / or the network load increases or other circumstances affects the network.

  8. Stretched exponential relaxation of piezovoltages in wet bovine bone.

    Science.gov (United States)

    Xu, Lianyun; Hou, Zhende; Fu, Donghui; Qin, Qing-Hua; Wang, Yihan

    2015-01-01

    It is important to determine the amplitude and variation characteristics of piezovoltage in wet bone, which can, in turn, be taken as a basis for studying whether electrical signals induced by external forces can affect the growth of bone cells. This work measured the characteristics of piezoelectric effects under dynamic and static loading. The results show that the variations of piezovoltage in wet bone in both loading and load holding periods follow a stretched exponential relaxation law, and the relaxation time constants of the piezovoltages are much larger than those of dry bone. This finding means that the active time of piezovoltage in wet bone is much longer than that of dry bone. Regardless of the loading and load holding processes, continuously increasing deformation in wet bone caused piezoelectric charges to be continuously induced and increased the dielectric constant of wet bone along with the deformation process. In general, compared with piezovoltage in dry bone, that in wet bone had lower amplitude and could exist for a longer duration. It can be inferred, therefore, that piezoelectricity might create coupling with the streaming potential in bone by changing the thickness of the double electrode layer. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. Assessing high altitude glacier volume change and remaining thickness using cost-efficient scientific techniques: the case of Nevado Coropuna (Peru

    Directory of Open Access Journals (Sweden)

    P. Peduzzi

    2009-10-01

    Full Text Available Higher temperature and change in precipitation patterns have induced an acute decrease in Andean glaciers, thus leading to an additional stress on water supply. To adapt to climate changes, local governments need information on the rate of glacier volume losses and on current ice thickness. We show how volume changes can be accurately estimated in remote areas using readily available low-cost digital elevation models derived from both topographic maps and satellite images. They were used for estimating the volume changes over the Coropuna glacier (Peru from 1955 to 2002. Ice thickness was measured in 2004 using a georadar coupled with Ground Positioning System during a field expedition. It provided profiles of ice thickness on different slopes, orientations and altitudes. These were used to model the current glacier volume using Geographical Information System and statistical multiple regressions techniques. Computers were modified to resists to high altitude (6500 m temperatures and low pressure conditions. The results delineated a significant glacier volume loss and provided an estimate of the remaining ice. It provided the scientific evidence needed by local Peruvian NGO, COPASA, and the German Cooperation Program in order to alert local governments and communities and for enforcing new climate change adaptation policies.

  10. Bivariate copulas on the exponentially weighted moving average control chart

    Directory of Open Access Journals (Sweden)

    Sasigarn Kuvattana

    2016-10-01

    Full Text Available This paper proposes four types of copulas on the Exponentially Weighted Moving Average (EWMA control chart when observations are from an exponential distribution using a Monte Carlo simulation approach. The performance of the control chart is based on the Average Run Length (ARL which is compared for each copula. Copula functions for specifying dependence between random variables are used and measured by Kendall’s tau. The results show that the Normal copula can be used for almost all shifts.

  11. Algebraic and transcendental solutions of some exponential equations

    CERN Document Server

    Sondow, Jonathan

    2011-01-01

    We study algebraic and transcendental powers of positive real numbers, including solutions of each of the equations $x^x=y$, $x^y=y^x$, $x^x=y^y$, $x^y=y$, and $x^{x^y}=y$. Applications to values of the iterated exponential functions are given. The main tools used are classical theorems of Hermite-Lindemann and Gelfond-Schneider, together with solutions of exponential Diophantine equations.

  12. EXPODE -- Advanced Exponential Time Integration Toolbox for MATLAB

    OpenAIRE

    2014-01-01

    We present a MATLAB toolbox for five different classes of exponential integrators for solving (mildly) stiff ordinary differential equations or time-dependent partial differential equations. For the efficiency of such exponential integrators it is essential to approximate the products of the matrix functions arising in these integrators with vectors in a stable, reliable and efficient way. The toolbox contains options for computing the matrix functions directly by diagonalization or by Pade a...

  13. AN ANALYTICAL SOLUTION FOR AN EXPONENTIAL TYPE DISPERSION PROCESS

    Institute of Scientific and Technical Information of China (English)

    王子亭

    2001-01-01

    The dispersion process in heterogeneous porous media is distance-dependent,which results from multi-scaling property of heterogeneous structure. An analytical model describing the dispersion with an exponential dispersion function is built, which is transformed into ODE problem with variable coefficients, and obtained analytical solution for two type boundary conditions using hypergeometric function and inversion technique.According to the analytical solution and computing results the difference between the exponential dispersion and constant dispersion process is analyzed.

  14. Confronting quasi-exponential inflation with WMAP seven

    Energy Technology Data Exchange (ETDEWEB)

    Pal, Barun Kumar; Pal, Supratik; Basu, B., E-mail: barunp1985@rediffmail.com, E-mail: pal@th.physik.uni-bonn.de, E-mail: banasri@isical.ac.in [Physics and Applied Mathematics Unit, Indian Statistical Institute, 203 B.T. Road, Kolkata 700 108 (India)

    2012-04-01

    We confront quasi-exponential models of inflation with WMAP seven years dataset using Hamilton Jacobi formalism. With a phenomenological Hubble parameter, representing quasi exponential inflation, we develop the formalism and subject the analysis to confrontation with WMAP seven using the publicly available code CAMB. The observable parameters are found to fair extremely well with WMAP seven. We also obtain a ratio of tensor to scalar amplitudes which may be detectable in PLANCK.

  15. Exponential order statistic models of software reliability growth

    Science.gov (United States)

    Miller, D. R.

    1986-01-01

    Failure times of a software reliability growth process are modeled as order statistics of independent, nonidentically distributed exponential random variables. The Jelinsky-Moranda, Goel-Okumoto, Littlewood, Musa-Okumoto Logarithmic, and Power Law models are all special cases of Exponential Order Statistic Models, but there are many additional examples also. Various characterizations, properties and examples of this class of models are developed and presented.

  16. FTEC: a coalescent simulator for modeling faster than exponential growth

    OpenAIRE

    Reppell, Mark; Boehnke, Michael; Zöllner, Sebastian

    2012-01-01

    Summary: Recent genetic studies as well as recorded history point to massive growth in human population sizes during the recent past. To model and understand this growth accurately we introduce FTEC, an easy-to-use coalescent simulation program capable of simulating haplotype samples drawn from a population that has undergone faster than exponential growth. Samples drawn from a population that has undergone faster than exponential growth show an excess of very rare variation and more rapid LD...

  17. Correlating anterior insula gray matter volume changes in young people with clinical and neurocognitive outcomes: an MRI study

    Directory of Open Access Journals (Sweden)

    Hatton Sean N

    2012-05-01

    Full Text Available Abstract Background The anterior insula cortex is considered to be both the structural and functional link between experience, affect, and behaviour. Magnetic resonance imaging (MRI studies have shown changes in anterior insula gray matter volume (GMV in psychosis, bipolar, depression and anxiety disorders in older patients, but few studies have investigated insula GMV changes in young people. This study examined the relationship between anterior insula GMV, clinical symptom severity and neuropsychological performance in a heterogeneous cohort of young people presenting for mental health care. Methods Participants with a primary diagnosis of depression (n = 43, bipolar disorder (n = 38, psychosis (n = 32, anxiety disorder (n = 12 or healthy controls (n = 39 underwent structural MRI scanning, and volumetric segmentation of the bilateral anterior insula cortex was performed using the FreeSurfer application. Statistical analysis examined the linear and quadratic correlations between anterior insula GMV and participants’ performance in a battery of clinical and neuropsychological assessments. Results Compared to healthy participants, patients had significantly reduced GMV in the left anterior insula (t = 2.05, p = .042 which correlated with reduced performance on a neuropsychological task of attentional set-shifting (ρ = .32, p = .016. Changes in right anterior insula GMV was correlated with increased symptom severity (r = .29, p = .006 and more positive symptoms (r = .32, p = .002. Conclusions By using the novel approach of examining a heterogeneous cohort of young depression, anxiety, bipolar and psychosis patients together, this study has demonstrated that insula GMV changes are associated with neurocognitive deficits and clinical symptoms in such young patients.

  18. Changes in glacier area and volume in Terskey Ala-Too Range in the second half of XX century

    Directory of Open Access Journals (Sweden)

    S. S. Kutuzov

    2012-01-01

    Full Text Available Changes in the extent of glaciers and rates of glacier termini retreat in the eastern Terskey-Alatoo Range, the Tien Shan Mountains, Central Asia have been evaluated using the remote sensing techniques. Changes in the extent of 109 glaciers between 1965, 1990 and 2003 have been estimated through the delineation of glacier outlines on the topographic maps, Landsat TM and ASTER imagery for 1965, 1990 and 2003 respectively. Glacier surface area has decreased by 12.6% of the 1965 value between 1965 and 2003. Detailed mapping of 10 glaciers using historical maps and aerial photographs from the 1943–1977 period, has enabled glacier extent variations over the 20th century to be identified with a higher temporal resolution. Glacial retreat was slow in the early 20th century but increased considerably between 1943 and 1956 and then again after 1977. The post-1990 period has been marked by the most rapid glacier retreat since the end of the LIA. For the selected 13 glaciers volume reduction has been evaluated using a time step digital elevation models. DEM obtained from the 1:25 000 topographic maps of 1965 and 1977 were compared to SRTM data. The observed changes in the extent of glaciers are in line with the observed climatic warming. The regional weather stations have revealed a strong climatic warming during the ablation season since the 1950s at a rate of 0.02–0.03 oC a-¹. At the higher elevations in the study area represented by the Tien Shan meteorological station, the summer warming was accompanied by negative anomalies in annual precipitation in the 1990s enhancing glacier retreat. However, trends in precipitation in the post-1997 period cannot be evaluated due to the change in observational practices at this station. Neither station in the study area exhibits significant long-term trends in precipitation.

  19. Upper bounds on a two-term exponential sum

    Institute of Scientific and Technical Information of China (English)

    Todd; Cochrane

    2001-01-01

    [1]Davenport, H. , Heibronn, H., On an exponential sum, Proc. Lond. Math. Soc., 1936, 41(2): 449-453.[2]Hua, L. K., On exponential sums, Sci. Record (Peking) (N.S.), 1957, 1: 1-4.[3]Vaughan, R. C. , The Hardy-Littlewood Method, 2nd ed. , Cambridge Tracts in Math. , Cambridge: Cambridge Univ. Press, 1997, 125.[4]Weil, A., On some exponential sums, Proc. Nat. Acad. Sci. USA, 1948, 34: 204-207.[5]Cochrane, T., Zheng, Z., Pure and mixed exponential sums, Acta Arith. , 1999, 91(3): 249-278.[6]Chalk, J. H. H., On Hua's estimate for exponential sums, Mathematika, 1987, 34: 115-123.[7]Loh, W. K. A. , Hua's Lemma, Bull. Australian Math. Soc., 1994, 50(3): 451-458.[8]Ding, P., An improvement to Chalk's estimation of exponential sums, Acta Arith. , 1991, 59(2): 149-155.

  20. Billiard representation for multidimensional multi-scalar cosmological model with exponential potentials

    CERN Document Server

    Dehnen, H; Melnikov, V N

    2003-01-01

    Multidimensional cosmological-type model with n Einstein factor spaces in the theory with l scalar fields and multiple exponential potential is considered. The dynamics of the model near the singularity is reduced to a billiard on the (N-1)-dimensional Lobachevsky space H^{N-1}, N = n+l. It is shown that for n > 1 the oscillating behaviour near the singularity is absent and solutions have an asymptotical Kasner-like behavior. For the case of one scale factor (n =1) billiards with finite volumes (e.g. coinciding with that of the Bianchi-IX model) are described and oscillating behaviour of scalar fields near the singularity is obtained.

  1. Camera on Vessel: A Camera-Based System to Measure Change in Water Volume in a Drinking Glass

    Directory of Open Access Journals (Sweden)

    Idowu Ayoola

    2015-09-01

    Full Text Available A major problem related to chronic health is patients’ “compliance” with new lifestyle changes, medical prescriptions, recommendations, or restrictions. Heart-failure and hemodialysis patients are usually placed on fluid restrictions due to their hemodynamic status. A holistic approach to managing fluid imbalance will incorporate the monitoring of salt-water intake, body-fluid retention, and fluid excretion in order to provide effective intervention at an early stage. Such an approach creates a need to develop a smart device that can monitor the drinking activities of the patient. This paper employs an empirical approach to infer the real water level in a conically shapped glass and the volume difference due to changes in water level. The method uses a low-resolution miniaturized camera to obtain images using an Arduino microcontroller. The images are processed in MATLAB. Conventional segmentation techniques (such as a Sobel filter to obtain a binary image are applied to extract the level gradient, and an ellipsoidal fitting helps to estimate the size of the cup. The fitting (using least-squares criterion between derived measurements in pixel and the real measurements shows a low covariance between the estimated measurement and the mean. The correlation between the estimated results to ground truth produced a variation of 3% from the mean.

  2. Model estimation of cerebral hemodynamics between blood flow and volume changes: a data-based modeling approach.

    Science.gov (United States)

    Wei, Hua-Liang; Zheng, Ying; Pan, Yi; Coca, Daniel; Li, Liang-Min; Mayhew, J E W; Billings, Stephen A

    2009-06-01

    It is well known that there is a dynamic relationship between cerebral blood flow (CBF) and cerebral blood volume (CBV). With increasing applications of functional MRI, where the blood oxygen-level-dependent signals are recorded, the understanding and accurate modeling of the hemodynamic relationship between CBF and CBV becomes increasingly important. This study presents an empirical and data-based modeling framework for model identification from CBF and CBV experimental data. It is shown that the relationship between the changes in CBF and CBV can be described using a parsimonious autoregressive with exogenous input model structure. It is observed that neither the ordinary least-squares (LS) method nor the classical total least-squares (TLS) method can produce accurate estimates from the original noisy CBF and CBV data. A regularized total least-squares (RTLS) method is thus introduced and extended to solve such an error-in-the-variables problem. Quantitative results show that the RTLS method works very well on the noisy CBF and CBV data. Finally, a combination of RTLS with a filtering method can lead to a parsimonious but very effective model that can characterize the relationship between the changes in CBF and CBV.

  3. Automatic Block Decomposition of Parametrically Changing Volumes Décomposition automatique par blocs de volumes variables paramétrisés

    Directory of Open Access Journals (Sweden)

    Taghavi R.

    2006-12-01

    Full Text Available A method is introduced for the automatic decomposition of time-varying volumes such as those encountered in engine FEA and CFD. Examples of the application of this method to all-hexahedral mesh generation are also presented. Une méthode est ici proposée pour la décomposition automatique. de volumes instationnaires tels que ceux rencontrés dans les moteurs en calculs de structure en élément finis ou de mécanique de fluides. Des exemples d'application de cette méthode à la génération de maillages en hexahèdre sont présentés.

  4. The Secular Evolution Of Disc Galaxies And The Origin Of Exponential And Double Exponential Surface Density Profiles

    Science.gov (United States)

    Elmegreen, Bruce G.

    2016-10-01

    Exponential radial profiles are ubiquitous in spiral and dwarf Irregular galaxies, but the origin of this structural form is not understood. This talk will review the observations of exponential and double exponential disks, considering both the light and the mass profiles, and the contributions from stars and gas. Several theories for this structure will also be reviewed, including primordial collapse, bar and spiral torques, clump torques, galaxy interactions, disk viscosity and other internal processes of angular momentum exchange, and stellar scattering off of clumpy structure. The only process currently known that can account for this structure in the most theoretically difficult case is stellar scattering off disks clumps. Stellar orbit models suggest that such scattering can produce exponentials even in isolated dwarf irregulars that have no bars or spirals, little shear or viscosity, and profiles that go out too far for the classical Mestel case of primordial collapse with specific angular momentum conservation.

  5. Early changes of parotid density and volume predict modifications at the end of therapy and intensity of acute xerostomia

    Energy Technology Data Exchange (ETDEWEB)

    Belli, Maria Luisa; Broggi, Sara [Ospedale San Raffaele Scientific Institute, Medical Physics, Milano (Italy); Scalco, Elisa; Rizzo, Giovanna [CNR, Istituto di Bioimmagini e Fisiologia Molecolare, Milano (Italy); Sanguineti, Giuseppe [Regina Elena National Cancer Institute, Department of Radiation Oncology, Rome (Italy); Fiorino, Claudio; Cattaneo, Giovanni Mauro [Ospedale San Raffaele Scientific Institute, Medical Physics, Milano (Italy); CNR, Istituto di Bioimmagini e Fisiologia Molecolare, Milano (Italy); Dinapoli, Nicola; Valentini, Vincenzo [Universita Cattolica del Sacro Cuore, Radiotherapy, Rome (Italy); Ricchetti, Francesco [Ospedale Sacro Cuore, Radiotherapy, Negrar (Italy)

    2014-11-15

    To quantitatively assess the predictive power of early variations of parotid gland volume and density on final changes at the end of therapy and, possibly, on acute xerostomia during IMRT for head-neck cancer. Data of 92 parotids (46 patients) were available. Kinetics of the changes during treatment were described by the daily rate of density (rΔρ) and volume (rΔvol) variation based on weekly diagnostic kVCT images. Correlation between early and final changes was investigated as well as the correlation with prospective toxicity data (CTCAEv3.0) collected weekly during treatment for 24/46 patients. A higher rΔρ was observed during the first compared to last week of treatment (-0,50 vs -0,05HU, p-value = 0.0001). Based on early variations, a good estimation of the final changes may be obtained (Δρ: AUC = 0.82, p = 0.0001; Δvol: AUC = 0.77, p = 0.0001). Both early rΔρ and rΔvol predict a higher ''mean'' acute xerostomia score (≥ median value, 1.57; p-value = 0.01). Median early density rate changes for patients with mean xerostomia score ≥ / < 1.57 were -0.98 vs -0.22 HU/day respectively (p = 0.05). Early density and volume variations accurately predict final changes of parotid glands. A higher longitudinally assessed score of acute xerostomia is well predicted by higher rΔρ and rΔvol in the first two weeks of treatment: best cut-off values were -0.50 HU/day and -380 mm{sup 3}/day for rΔρ and rΔvol respectively. Further studies are necessary to definitively assess the potential of early density/volume changes in identifying more sensitive patients at higher risk of experiencing xerostomia. (orig.) [German] Ziel der Studie ist die Untersuchung der praediktiven Aussagekraft von fruehen Veraenderungen in Volumen und Dichte der Ohrspeicheldruese in Bezug auf die finale Verformung zum Ende der Therapie sowie das Risiko von Xerostomie waehrend der intesitaetsmodulierten Strahlentherapie (IMRT) bei Kopf und Hals Tumoren. Die Studie

  6. Exponential growth combined with exponential decline explains lifetime performance evolution in individual and human species.

    Science.gov (United States)

    Berthelot, Geoffroy; Len, Stéphane; Hellard, Philippe; Tafflet, Muriel; Guillaume, Marion; Vollmer, Jean-Claude; Gager, Bruno; Quinquis, Laurent; Marc, Andy; Toussaint, Jean-François

    2012-08-01

    The physiological parameters characterizing human capacities (the ability to move, reproduce or perform tasks) evolve with ageing: performance is limited at birth, increases to a maximum and then decreases back to zero at the day of death. Physical and intellectual skills follow such a pattern. Here, we investigate the development of sport and chess performances during the lifetime at two different scales: the individual athletes' careers and the world record by age class in 25 Olympic sports events and in grandmaster chess players. For all data sets, a biphasic development of growth and decline is described by a simple model that accounts for 91.7% of the variance at the individual level and 98.5% of the variance at the species one. The age of performance peak is computed at 26.1 years old for the events studied (26.0 years old for track and field, 21.0 years old for swimming and 31.4 years old for chess). The two processes (growth and decline) are exponential and start at age zero. Both were previously demonstrated to happen in other human and non-human biological functions that evolve with age. They occur at the individual and species levels with a similar pattern, suggesting a scale invariance property.

  7. The influence of peat volume change and vegetation on the hydrology of a kettle-hole wetland in Southern Ontario, Canada

    Directory of Open Access Journals (Sweden)

    P. Whittington

    2007-12-01

    Full Text Available Links between local hydrology and vegetation type exist in wetlands, yet it is unclear what role peat volume change plays in these interactions. We measured peat volume change and hydraulic conductivity (Kfield at three contrasting sites located on the quaking vegetation mat of a kettle-hole peatland in southern Ontario. The three sites had visibly different plant communities and were named, according to their dominant vegetation, Sedge (Carex spp., Typha (Typha angustifolia and Carr (Cornus stolonifera. Peat was also collected for laboratory studies of peat volume change, vertical (Kv and horizontal (Kh hydraulic conductivity and the effect of compression on hydraulic conductivity (Kc.In the field, the water table rose throughout the study period, resulting in swelling of the peat. Peat volume change above the -100 cm layer was 11.2%, 6.0% and 3.8% at the Sedge, Typha, and Carr sites respectively. In laboratory samples, a falling water table caused compression of the peat below the structured surface mat, and relative peat volume change between the sites followed the same pattern as in the field. Kfield, Kv and Kh generally decreased with depth from ca. 10-2 to 10-6 cm s-1. In the surface layers (0 to -50cm K trended Carr>Typha>Sedge, whereas the reverse trend was observed in deeper peat. Artificial compression affected K only in the uppermost layers (0 to -15cm. The decline in Kc with compression also trended Sedge>Typha>Carr. Differences in peat volume change and K are probably related to differences in vegetation and soil structure, and may be important for maintaining suitable growing conditions within each community.

  8. Changes in Myocardial Composition and Conduction Properties in Rat Heart Failure Model Induced by Chronic Volume Overload

    Directory of Open Access Journals (Sweden)

    David Sedmera

    2016-08-01

    Full Text Available Volume overload leads to development of eccentric cardiac hypertrophy and heart failure. In our previous report, we have shown myocyte hypertrophy with no fibrosis and decrease in gap junctional coupling via connexin43 in a rat model of aorto-caval fistula at 21 weeks. Here we set to analyze the electrophysiological and protein expression changes in the left ventricle and correlate them with phenotypic severity based upon ventricles to body weight ratio.ECG analysis showed increased amplitude and duration of the P wave, prolongation of PR and QRS interval, ST segment elevation and decreased T wave amplitude in the fistula group. Optical mapping showed a prolongation of action potential duration in the hypertrophied hearts. Minimal conduction velocity (CV showed a bell-shaped curve, with a significant increase in the mild cases and there was a negative correlation of both minimal and maximal CV with heart to body weight ratio. Since the CV is influenced by gap junctional coupling as well as the autonomic nervous system, we measured the amounts of tyrosine hydroxylase (TH and choline acetyl transferase (ChAT as a proxy for sympathetic and parasympathetic innervation, respectively. At the protein level, we confirmed a significant decrease in total and phosphorylated connexin43 that was proportional to the level of hypertrophy, and similarly decreased levels of TH and ChAT.Even at a single time-point, severity of morphological phenotype correlates with progression of molecular and electrophysiological changes, with the most hypertrophied hearts showing the most severe changes that might be related to arrhythmogenesis.

  9. A new linearly-combined bi-exponential model for kinetic analysis of the isometric relaxation process of Bufo gastrocnemius under electric stimulation in vitro

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    There was a slow-relaxing tail of skeletal muscles in vitro upon the inhibition of Ca2+-pump by cyclopiazonic acid (CPA). Herein, a new linearly-combined bi-exponential model to resolve this slow-relaxing tail from the fast-relaxing phase was investigated for kinetic analysis of the isometric relaxation process of Bufo gastrocnemius in vitro, in comparison to the single exponential model and the classical bi-exponential model. During repetitive stimulations at a 2-s interval by square pulses of a 2-ms duration at 12 V direct currency (DC), the isometric tension of Bufo gastrocnemius was recorded at 100 Hz. The relaxation curve with tensions falling from 90% of the peak to the 15th datum before next stimulation was analyzed by three exponential models using a program in MATLAB 6.5. Both the goodness of fit and the distribution of the residuals for the best fitting supported the comparable validity of this new bi-exponential model for kinetic analysis of the relaxation process of the control muscles. After CPA treatment, however, this new bi-exponential model showed an obvious statistical superiority for kinetic analysis of the muscle relaxation process, and it gave the estimated rest tension consistent to that by experimentation, whereas both the classical bi-exponential model and the single exponential model gave biased rest tensions. Moreover, after the treatment of muscles by CPA, both the single exponential model and the classical bi-exponential model yielded lowered relaxation rates,nevertheless, this new bi-exponential model had relaxation rates of negligible changes except much higher rest tensions. These results suggest that this novel linearly-combined bi-exponential model is desirable for kinetic analysis of the relaxation process of muscles with altered Ca2+-pumping activity.

  10. Changes in the electro-physical properties of MCT epitaxial films affected by a plasma volume discharge induced by an avalanche beam in atmospheric-pressure air

    Science.gov (United States)

    Grigoryev, D. V.; Voitsekhovskii, A. V.; Lozovoy, K. A.; Tarasenko, V. F.; Shulepov, M. A.

    2015-11-01

    In this paper the influence of the plasma volume discharge of nanosecond duration formed in a non-uniform electric field at atmospheric pressure on samples of epitaxial films HgCdTe (MCT) films are discussed. The experimental data show that the action of pulses of nanosecond volume discharge in air at atmospheric pressure leads to changes in the electrophysical properties of MCT epitaxial films due to formation of a near-surface high- conductivity layer of the n-type conduction. The preliminary results show that it is possible to use such actions in the development of technologies for the controlled change of the properties of MCT.

  11. A longitudinal study of the relationship between personality traits and the annual rate of volume changes in regional gray matter in healthy adults.

    Science.gov (United States)

    Taki, Yasuyuki; Thyreau, Benjamin; Kinomura, Shigeo; Sato, Kazunori; Goto, Ryoi; Wu, Kai; Kawashima, Ryuta; Fukuda, Hiroshi

    2013-12-01

    To investigate whether personality traits affect the rate of decline of gray matter volume, we analyzed the relationships between personality traits and the annual rate of changes of gray matter volume in 274 healthy community dwelling subjects with a large age range by applying a longitudinal design over 6 years, using brain magnetic resonance images (MRI) and the Revised NEO Personality Inventory (NEO-PI-R) at baseline. Brain MRI data were processed using voxel-based morphometry with a custom template by applying the DARTEL diffeomorphic registration tool. For each subject, we used NEO-PI-R to evaluate the five major personality traits, including neuroticism, extraversion, openness, agreeableness, and conscientiousness. The results show that the annual rate of change in regional gray matter volume in the right inferior parietal lobule was correlated significantly and negatively with a personality of openness, which is known to be related to intellect, intellectual curiosity, and creativity adjusting for age, gender, and intracranial volume. This result indicates that subjects with a personality trait of less openness have an accelerated loss of gray matter volume in the right inferior parietal lobule, compared with subjects with a personality trait of more openness. Because the right inferior parietal lobule is involved in higher cognitive function such as working memory and creativity, a personality trait of openness is thought to be important for preserving gray matter volume and cognitive function of the right inferior parietal lobule in healthy adults.

  12. Hypofractionated stereotactic radiotherapy of acoustic neuroma. Volume changes and hearing results after 89-month median follow-up

    Energy Technology Data Exchange (ETDEWEB)

    Kranzinger, Manfred; Fastner, Gerd [Paracelsus Medical University Clinics (PMU), University Clinic of Radiotherapy and Radio-Oncology, Salzburg County Hospital, Salzburg (Austria); Zehentmayr, Franz; Sedlmayer, Felix [Paracelsus Medical University Clinics (PMU), University Clinic of Radiotherapy and Radio-Oncology, Salzburg County Hospital, Salzburg (Austria); Salzburg County Hospital, Paracelsus Medical University Clinics, radART - Institute for Research and Development on Advanced Radiation Technologies, Salzburg (Austria); Oberascher, Gerhard [Paracelsus Medical University Clinics (PMU), University Clinic of Ear, Nose and Throat Diseases, Salzburg County Hospital, Salzburg (Austria); Merz, Florian; Rahim, Hassan [Salzburg County Hospital, Paracelsus Medical University Clinics, Medical Radiation Protection Unit, Salzburg (Austria); Nairz, Olaf [Clinic Bad Trissl, Oberaudorf (Germany)

    2014-09-15

    The goal of this work was to evaluate toxicity and local control following hypofractionated stereotactic radiation treatment with special focus on changes in tumor volume and hearing capacity. In all, 29 patients with unilateral acoustic neuroma were treated between 2001 and 2007 within a prospective radiation protocol (7 x 4 Gy ICRU dose). Median tumor volume was 0.9 ml. Follow-up started at 6 months and was repeated annually with MRI volumetry and audiometry. Hearing preservation was defined as preservation of Class A/B hearing according to the guidelines of the American Academy of Otolaryngology (1995). No patient had any intervention after a median imaging follow-up of 89.5 months, one patient showed radiological progression. Transient increase of tumor volume developed in 17/29 patients, whereas 22/29 patients (75.9 %) presented with a volume reduction at last follow-up. A total of 21 patients were eligible for hearing evaluation. Mean pure tone average (PTA) deteriorated from 39.3 to 65.9 dB and mean speech discrimination score (SDS) dropped from 74.3 to 38.1 %. The 5-year actuarial Class A/B hearing preservation rate was 50.0 ± 14.4 %. Radiation increases only minimally, if at all, the hearing deterioration which emerges by observation alone. Presbyacusis is not responsible for this deterioration. Transient tumor enlargement is common. Today radiation of small- and medium-sized acoustic neuroma can be performed with different highly conformal techniques as fractionated treatment or single low-dose radiosurgery with equal results regarding tumor control, hearing preservation, and side effects. Hypofractionation is more comfortable for the patient than conventional regimens and represents a serious alternative to frameless radiosurgery. (orig.) [German] Ziel der Studie war die Evaluierung der Toxizitaet und der lokalen Tumorkontrolle einer hypofraktionierten stereotaktischen Bestrahlung mit besonderem Augenmerk auf Veraenderungen von Tumorvolumen und

  13. A longitudinal study of stress-induced hippocampal volume changes in mice that are susceptible or resilient to chronic social defeat.

    Science.gov (United States)

    Tse, Yiu Chung; Montoya, Ixchel; Wong, Alice S; Mathieu, Axel; Lissemore, Jennifer; Lagace, Diane C; Wong, Tak Pan

    2014-09-01

    Hippocampal shrinkage is a commonly found neuroanatomical change in stress-related mood disorders such as depression and post-traumatic stress disorders (PTSD). Since the onset and severity of these disorders have been found to be closely related to stressful life events, and as stress alone has been shown to reduce hippocampal volume in animal studies, vulnerability to mood disorders may be related to a susceptibility to stress-induced hippocampal shrinkage. However, a smaller hippocampal volume before stress exposure has also been suggested to confer vulnerability of stressed individuals to PTSD or depression. In this study, we examined the contribution of either innate hippocampal volume differences or hippocampal susceptibility to stress-induced shrinkage to the formation of stress-related psychopathology using longitudinal MRI measurements of hippocampal volume in inbred C57 mice before and after chronic social defeat stress. We found that only half of the stressed C57 mice were susceptible to stress and developed psychopathological behaviors such as social avoidance. The other half was resilient to stress and exhibited no social avoidance. Before exposure to stress, we observed a positive correlation between hippocampal volume and social avoidance. After chronic social defeat stress, we found significant increases in left hippocampal volume in resilient and nonstressed control mice. Intriguingly, this increase in hippocampal volume was not found in susceptible mice, suggesting an arrestment of hippocampal growth in these mice. Our findings suggest that both a susceptibility to stress-induced hippocampal volume changes and a larger hippocampus before stress exposure confer vulnerability to psychopathology after chronic stress. © 2014 Wiley Periodicals, Inc.

  14. Bayesian estimation of generalized exponential distribution under noninformative priors

    Science.gov (United States)

    Moala, Fernando Antonio; Achcar, Jorge Alberto; Tomazella, Vera Lúcia Damasceno

    2012-10-01

    The generalized exponential distribution, proposed by Gupta and Kundu (1999), is a good alternative to standard lifetime distributions as exponential, Weibull or gamma. Several authors have considered the problem of Bayesian estimation of the parameters of generalized exponential distribution, assuming independent gamma priors and other informative priors. In this paper, we consider a Bayesian analysis of the generalized exponential distribution by assuming the conventional noninformative prior distributions, as Jeffreys and reference prior, to estimate the parameters. These priors are compared with independent gamma priors for both parameters. The comparison is carried out by examining the frequentist coverage probabilities of Bayesian credible intervals. We shown that maximal data information prior implies in an improper posterior distribution for the parameters of a generalized exponential distribution. It is also shown that the choice of a parameter of interest is very important for the reference prior. The different choices lead to different reference priors in this case. Numerical inference is illustrated for the parameters by considering data set of different sizes and using MCMC (Markov Chain Monte Carlo) methods.

  15. Non-exponential and oscillatory decays in quantum mechanics

    Energy Technology Data Exchange (ETDEWEB)

    Peshkin, Murray [Argonne National Lab. (ANL), Argonne, IL (United States); Volya, Alexander [Florida State Univ., Tallahassee, FL (United States); Zelevinsky, Vladimir [Michigan State Univ., East Lansing, MI (United States)

    2014-08-07

    The quantum-mechanical theory of the decay of unstable states is revisited. We show that the decay is non-exponential both in the short-time and long-time limits using a more physical definition of the decay rate than the one usually used. We report results of numerical studies based on Winter's model that may elucidate qualitative features of exponential and non-exponential decay more generally. The main exponential stage is related to the formation of a radiating state that maintains the shape of its wave function with exponentially diminishing normalization. We discuss situations where the radioactive decay displays several exponents. The transient stages between different regimes are typically accompanied by interference of various contributions and resulting oscillations in the decay curve. The decay curve can be fully oscillatory in a two-flavor generalization of Winter's model with some values of the parameters. We consider the implications of that result for models of the oscillations reported by GSI.

  16. Effects of the volume changes and elastic-strain energies on the phase transition in the Li-Sn battery

    Science.gov (United States)

    Zhang, Fan; Wang, Jianchuan; Liu, Shuhong; Du, Yong

    2016-10-01

    Sn and Sn-based compounds have been attracting a great interest as promising alternative materials for commercial anodes in lithium ion batteries. In this study, the phase evolution of the Li-Sn system during the lithiated processes and the effect of the elastic-strain energies caused by volume change on the phase transition are investigated by means of first-principles calculations. Our calculated results demonstrate that the distorted Li7Sn3 crystal tends to be formed in order to decrease the elastic-strain energy. In addition, our work indicates that the whole lithiated processes under the elastically constrained condition could be classified into two steps. The first step is the two-phase equilibrium process, in which the thermodynamic driving force is large enough to facilitate the phase transition and the plateau voltage could be established. The second step is considered to be the selective equilibrium, in which the thermodynamic driving force is not enough to facilitate the nucleation of the new equilibrium phase due to the elastically constrained conditions and the plateau voltage unformed. Besides, we find that in the Li0.4Sn matrix the nucleation of the αSn is more preferential than the βSn due to the effects of the elastic-strain energies.

  17. Constraints on geothermal reservoir volume change calculations from InSAR surface displacements and injection and production data

    Science.gov (United States)

    Kaven, J. Ole; Barbour, Andrew J.; Ali, Tabrez

    2017-04-01

    Continual production of geothermal energy at times leads to significant surface displacement that can be observed in high spatial resolution using InSAR imagery. The surface displacement can be analyzed to resolve volume change within the reservoir revealing the often-complicated patterns of reservoir deformation. Simple point source models of reservoir deformation in a homogeneous elastic or poro-elastic medium can be superimposed to provide spatially varying, kinematic representations of reservoir deformation. In many cases, injection and production data are known in insufficient detail; but, when these are available, the same Green functions can be used to constrain the reservoir deformation. Here we outline how the injection and production data can be used to constrain bounds on the solution by posing the inversion as a quadratic programming with inequality constraints and regularization rather than a conventional least squares solution with regularization. We apply this method to InSAR-derived surface displacements at the Coso and Salton Sea Geothermal Fields in California, using publically available injection and production data. At both geothermal fields the available surface deformation in conjunction with the injection and production data permit robust solutions for the spatially varying reservoir deformation. The reservoir deformation pattern resulting from the constrained quadratic programming solution is more heterogeneous when compared to a conventional least squares solution. The increased heterogeneity is consistent with the known structural controls on heat and fluid transport in each geothermal reservoir.

  18. Split exponential track length estimator for Monte-Carlo simulations of small-animal radiation therapy

    Science.gov (United States)

    Smekens, F.; Létang, J. M.; Noblet, C.; Chiavassa, S.; Delpon, G.; Freud, N.; Rit, S.; Sarrut, D.

    2014-12-01

    We propose the split exponential track length estimator (seTLE), a new kerma-based method combining the exponential variant of the TLE and a splitting strategy to speed up Monte Carlo (MC) dose computation for low energy photon beams. The splitting strategy is applied to both the primary and the secondary emitted photons, triggered by either the MC events generator for primaries or the photon interactions generator for secondaries. Split photons are replaced by virtual particles for fast dose calculation using the exponential TLE. Virtual particles are propagated by ray-tracing in voxelized volumes and by conventional MC navigation elsewhere. Hence, the contribution of volumes such as collimators, treatment couch and holding devices can be taken into account in the dose calculation. We evaluated and analysed the seTLE method for two realistic small animal radiotherapy treatment plans. The effect of the kerma approximation, i.e. the complete deactivation of electron transport, was investigated. The efficiency of seTLE against splitting multiplicities was also studied. A benchmark with analog MC and TLE was carried out in terms of dose convergence and efficiency. The results showed that the deactivation of electrons impacts the dose at the water/bone interface in high dose regions. The maximum and mean dose differences normalized to the dose at the isocenter were, respectively of 14% and 2% . Optimal splitting multiplicities were found to be around 300. In all situations, discrepancies in integral dose were below 0.5% and 99.8% of the voxels fulfilled a 1%/0.3 mm gamma index criterion. Efficiency gains of seTLE varied from 3.2 × 105 to 7.7 × 105 compared to analog MC and from 13 to 15 compared to conventional TLE. In conclusion, seTLE provides results similar to the TLE while increasing the efficiency by a factor between 13 and 15, which makes it particularly well-suited to typical small animal radiation therapy applications.

  19. Relations between slow extracellular potential changes, glial potassium buffering, and electrolyte and cellular volume changes during neuronal hyperactivity in cat brain.

    Science.gov (United States)

    Dietzel, I; Heinemann, U; Lux, H D

    1989-01-01

    The aim of this investigation is to estimate the contribution of spatial glial K+ buffer currents to extracellular K+ homeostasis during enhanced neuronal activity. Neuronal hyperactivity was induced by electrical stimulation of the cortical surface or the ventrobasal thalamic nuclei of cats (5-50 Hz, 0.1-0.2 ms, two to three times threshold stimulation intensity, 5-20 s). The accompanying slow field potential changes were recorded simultaneously across the grey matter with vertical assemblies of eight micropipettes glued 300 microns apart. Using the Poisson equation, the amplitudes of the underlying current sources and sinks were calculated. The current source densities depended on the depth of recording, frequency, strength, and duration of the stimulation. Current sinks, corresponding to a removal of 0.1-0.5 mmoles of monovalent cations per liter of brain tissue and second from the extracellular space, were observed in middle cortical layers, whereas sources appeared at superficial and deeper sites. These sinks and sources might represent K+ moved across glial membranes by spatial buffer currents. The consequences of glial buffer currents of this magnitude were investigated with model calculations. It turned out that measurements of electrolyte and volume changes of the extracellular space (Dietzel et al. Exp. Brain Res. 40:432-439, 1980; Exp. Brain Res. 46:73-84, 1982) could only partially be explained by spatial buffer currents of this magnitude. Comparison of the calculated values with intracellular measurements in neurons and glial cells (Coles et al. Ann. N.Y. Acad. Sci. 481:303-317, 1986; Ballanyi et al. J. Physiol. 382:159-174, 1987) suggests that spatial buffering combines with an approximately equimolar KCl transport and, depending on the preparation, also K+/Na+-exchange across glial membranes.

  20. Thermal analysis of laser interstitial thermotherapy in ex vivo fibro-fatty tissue using exponential functions

    Energy Technology Data Exchange (ETDEWEB)

    Salas, Nelson Jr. [Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, PO Box 248294, Coral Gables, FL 33124 (United States); Manns, Fabrice [Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, PO Box 248294, Coral Gables, FL 33124 (United States); Milne, Peter J [Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, 1638 NW 10th Ave, McKnight Bldg, Miami, FL 33136 (United States); Denham, David B [Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, 1638 NW 10th Ave, McKnight Bldg, Miami, FL 33136 (United States); Minhaj, Ahmed M [Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, PO Box 248294, Coral Gables, FL 33124 (United States); Parel, Jean-Marie [Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, PO Box 248294, Coral Gables, FL 33124 (United States); Robinson, David S [Center for Breast Care, St Luke' s Hospital of Kansas City, 4400 Broadway, Suite 509, Kansas City, MO 64111 (United States)

    2004-05-07

    A therapeutic procedure to treat small, surface breast tumours up to 10 mm in radius plus a 5 mm margin of healthy, surrounding tissue using laser interstitial thermotherapy (LITT) is currently being investigated. The purpose of this study is to analyse and model the thermal and coagulative response of ex vivo fibro-fatty tissue, a model for breast tissue, during experimental laser interstitial thermotherapy at 980 nm. Laser radiation at 980 nm was delivered interstitially through a diffusing tip optical fibre inserted into a fibro-fatty tissue model to produce controlled heating at powers ranging from 3.2 to 8.0 W. Tissue temperature was measured with thermocouples placed at 15 positions around the fibre. The induced coagulation zone was measured on gross anatomical sections. Thermal analysis indicates that a finite sum of exponential functions is an approximate solution to the heat conduction equation that more accurately predicts the time-temperature dependence in tissue prior to carbonization (T < 100 deg. C) during LITT than the traditional model using a single exponential function. Analysis of the ellipsoid coagulation volume induced in tissue indicates that the 980 nm wavelength does not penetrate deep enough in fibro-fatty tissue to produce a desired 30 mm diameter (14.1 x 10{sup 3} mm{sup 3}) coagulation volume without unwanted tissue liquefaction and carbonization.

  1. Minimizing Mobiles Communication Time Using Modified Binary Exponential Backoff Algorithm

    Directory of Open Access Journals (Sweden)

    Ibrahim Sayed Ahmad

    2013-11-01

    Full Text Available The domain of wireless Local Area Networks (WLANsis growing speedily as a consequence ofdevelopments in digital communications technology.The early adopters of this technology have mainlybeen vertical applicationthat places a premium on the mobility offered by such systems. Examples of thesetypes of applications consist of stocking control in depot environments,point of sale terminals, and rentalcar check-in. Furthermore to the mobility thatbecomes possible with wireless LANs; these systemshavealso been used in environments where cable installation is expensive or impractical. Such environmentsincludemanufacturingfloors, tradingfloors on stock exchanges, conventions and trade shows,and historicbuildings. With the increasing propagation of wireless LANs comes theneed for standardization so as toallow interoperability for an increasingly mobileworkforce. Despite all the advantages and facilities thatWi-FI offers, there is still the delay problem thatis due to many reasons that are introduced in details inour case study which also presents the solutions and simulation that can reduce this delay for betterperformance of the wireless networks.Binary Exponential Backoff (BEB refers to a collision resolution mechanism used in random access MACprotocols. This algorithm is used in Ethernet (IEEE802.3 wired LANs. In Ethernet networks, thisalgorithm is commonly used to schedule retransmissions after collisions.The paper’s goal is to minimize the time transmission cycle of the information between mobiles movingin aWi-Fi by changing the BEB algorithm. The Protocol CSMA / CA manage access to the radio channel byperforming an arbitration based on time. This causes many problems in relation to time transmissionbetween mobiles moving in a cell 802.11. what we have done show that the protocol using CSMA / CAaccess time believed rapidly when the number of stations and / or the network load increases or othercircumstances affects the network.

  2. Surface properties and exponential stress relaxations of mammalian meibum films.

    Science.gov (United States)

    Eftimov, Petar; Yokoi, Norihiko; Tonchev, Vesselin; Nencheva, Yana; Georgiev, Georgi As

    2017-03-01

    The surface properties of meibomian secretion (MGS), the major constituent of the tear film (TF) lipid layer, are of key importance for TF stability. The interfacial properties of canine, cMGS, and feline, fMGS, meibum films were studied using a Langmuir surface balance. These species were selected because they have blinking frequency and TF stability similar to those of humans. The sample's performance during dynamic area changes was evaluated by surface pressure (π)-area (A) isocycles and the layer structure was monitored with Brewster angle microscopy. The films' dilatational rheology was probed via the stress-relaxation technique. The animal MGS showed similar behavior both between each other and with human MGS (studied previously). They form reversible, non-collapsible, multilayer thick films. The relaxations of canine, feline, and human MGS films were well described by double exponential decay reflecting the presence of two processes: (1) fast elastic process, with characteristic time τ  100 s-emphasizing the meibum layers viscoelasticity. The temperature decrease from 35 to 25 °C resulted in decreased thickness and lateral expansion of all MGS layers accompanied with increase of the π/A hysteresis and of the elastic process contribution to π relaxation transients. Thus, MGS films of mammals with similar blinking frequency and TF stability have similar surface properties and stress relaxations unaltered by the interspecies MGS compositional variations. Such knowledge may impact the selection of animal mimics of human MGS and on a better understanding of lipid classes' impact on meibum functionality.

  3. Exponential Sensitivity and its Cost in Quantum Physics.

    Science.gov (United States)

    Gilyén, András; Kiss, Tamás; Jex, Igor

    2016-02-10

    State selective protocols, like entanglement purification, lead to an essentially non-linear quantum evolution, unusual in naturally occurring quantum processes. Sensitivity to initial states in quantum systems, stemming from such non-linear dynamics, is a promising perspective for applications. Here we demonstrate that chaotic behaviour is a rather generic feature in state selective protocols: exponential sensitivity can exist for all initial states in an experimentally realisable optical scheme. Moreover, any complex rational polynomial map, including the example of the Mandelbrot set, can be directly realised. In state selective protocols, one needs an ensemble of initial states, the size of which decreases with each iteration. We prove that exponential sensitivity to initial states in any quantum system has to be related to downsizing the initial ensemble also exponentially. Our results show that magnifying initial differences of quantum states (a Schrödinger microscope) is possible; however, there is a strict bound on the number of copies needed.

  4. On the Exponential Probability Bounds for the Bernoulli Random Variables

    CERN Document Server

    Nikulin, Vladimir

    2010-01-01

    We consider upper exponential bounds for the probability of the event that an absolute deviation of sample mean from mathematical expectation p is bigger comparing with some ordered level epsilon. These bounds include 2 coefficients {alpha, beta}. In order to optimize the bound we are interested to minimize linear coefficient alpha and to maximize exponential coefficient beta. Generally, the value of linear coefficient alpha may not be smaller than one. The following 2 settings were proved: 1) {1, 2} in the case of classical discreet problem as it was formulated by Bernoulli in the 17th century, and 2) {1, 2/(1+epsilon^2)} in the general discreet case with arbitrary rational p and epsilon. The second setting represents a new structure of the exponential bound which may be extended to continuous case.

  5. Exponential rise of dynamical complexity in quantum computing through projections.

    Science.gov (United States)

    Burgarth, Daniel Klaus; Facchi, Paolo; Giovannetti, Vittorio; Nakazato, Hiromichi; Pascazio, Saverio; Yuasa, Kazuya

    2014-10-10

    The ability of quantum systems to host exponentially complex dynamics has the potential to revolutionize science and technology. Therefore, much effort has been devoted to developing of protocols for computation, communication and metrology, which exploit this scaling, despite formidable technical difficulties. Here we show that the mere frequent observation of a small part of a quantum system can turn its dynamics from a very simple one into an exponentially complex one, capable of universal quantum computation. After discussing examples, we go on to show that this effect is generally to be expected: almost any quantum dynamics becomes universal once 'observed' as outlined above. Conversely, we show that any complex quantum dynamics can be 'purified' into a simpler one in larger dimensions. We conclude by demonstrating that even local noise can lead to an exponentially complex dynamics.

  6. Kullback-Leibler divergence and the Pareto-Exponential approximation.

    Science.gov (United States)

    Weinberg, G V

    2016-01-01

    Recent radar research interests in the Pareto distribution as a model for X-band maritime surveillance radar clutter returns have resulted in analysis of the asymptotic behaviour of this clutter model. In particular, it is of interest to understand when the Pareto distribution is well approximated by an Exponential distribution. The justification for this is that under the latter clutter model assumption, simpler radar detection schemes can be applied. An information theory approach is introduced to investigate the Pareto-Exponential approximation. By analysing the Kullback-Leibler divergence between the two distributions it is possible to not only assess when the approximation is valid, but to determine, for a given Pareto model, the optimal Exponential approximation.

  7. On the performance of exponential integrators for problems in magnetohydrodynamics

    CERN Document Server

    Einkemmer, Lukas; Loffeld, John

    2016-01-01

    Exponential integrators have been introduced as an efficient alternative to explicit and implicit methods for integrating large stiff systems of differential equations. Over the past decades these methods have been studied theoretically and their performance was evaluated using a range of test problems. While the results of these investigations showed that exponential integrators can provide significant computational savings, the research on validating this hypothesis for large scale systems and understanding what classes of problems can particularly benefit from the use of the new techniques is in its initial stages. Resistive magnetohydrodynamic (MHD) modeling is widely used in studying large scale behavior of laboratory and astrophysical plasmas. In many problems numerical solution of MHD equations is a challenging task due to the temporal stiffness of this system in the parameter regimes of interest. In this paper we evaluate the performance of exponential integrators on large MHD problems and compare the...

  8. Exponential stretch-rotation (ESR) formulation of general relativity

    CERN Document Server

    Khokhlov, A M

    2003-01-01

    We study a tensorial exponential transformation of a three-dimensional metric of space-like hypersurfaces embedded in a four-dimensional space-time, $\\gamma_{ij} = e^{\\epsilon_{ikm}\\theta_m} e^{\\phi_k} e^{-\\epsilon_{jkn}\\theta_n}$, where $\\phi_k$ are logarithms of the eigenvalues of $\\gamma_{ij}$, $\\theta_k$ are rotation angles, and $\\epsilon_{ijk}$ is a fully anti-symmetric symbol. Evolution part of Einstein's equations, formulated in terms of $\\phi_k$ and $\\theta_k$, describes time evolution of the metric at every point of a hyper-surface as a continuous stretch and rotation of a local coordinate system in a tangential space. The exponential stretch-rotation (ESR) transformation generalizes particular exponential transformations used previously in cases of spatial symmetry. The ESR 3+1 formulation of Einstein's equations may have certain advantages for long-term stable integration of these equations.

  9. Design of a 9-loop quasi-exponential waveform generator.

    Science.gov (United States)

    Banerjee, Partha; Shukla, Rohit; Shyam, Anurag

    2015-12-01

    We know in an under-damped L-C-R series circuit, current follows a damped sinusoidal waveform. But if a number of sinusoidal waveforms of decreasing time period, generated in an L-C-R circuit, be combined in first quarter cycle of time period, then a quasi-exponential nature of output current waveform can be achieved. In an L-C-R series circuit, quasi-exponential current waveform shows a rising current derivative and thereby finds many applications in pulsed power. Here, we have described design and experiment details of a 9-loop quasi-exponential waveform generator. In that, design details of magnetic switches have also been described. In the experiment, output current of 26 kA has been achieved. It has been shown that how well the experimentally obtained output current profile matches with the numerically computed output.

  10. On the performance of exponential integrators for problems in magnetohydrodynamics

    Science.gov (United States)

    Einkemmer, Lukas; Tokman, Mayya; Loffeld, John

    2017-02-01

    Exponential integrators have been introduced as an efficient alternative to explicit and implicit methods for integrating large stiff systems of differential equations. Over the past decades these methods have been studied theoretically and their performance was evaluated using a range of test problems. While the results of these investigations showed that exponential integrators can provide significant computational savings, the research on validating this hypothesis for large scale systems and understanding what classes of problems can particularly benefit from the use of the new techniques is in its initial stages. Resistive magnetohydrodynamic (MHD) modeling is widely used in studying large scale behavior of laboratory and astrophysical plasmas. In many problems numerical solution of MHD equations is a challenging task due to the temporal stiffness of this system in the parameter regimes of interest. In this paper we evaluate the performance of exponential integrators on large MHD problems and compare them to a state-of-the-art implicit time integrator. Both the variable and constant time step exponential methods of EPIRK-type are used to simulate magnetic reconnection and the Kevin-Helmholtz instability in plasma. Performance of these methods, which are part of the EPIC software package, is compared to the variable time step variable order BDF scheme included in the CVODE (part of SUNDIALS) library. We study performance of the methods on parallel architectures and with respect to magnitudes of important parameters such as Reynolds, Lundquist, and Prandtl numbers. We find that the exponential integrators provide superior or equal performance in most circumstances and conclude that further development of exponential methods for MHD problems is warranted and can lead to significant computational advantages for large scale stiff systems of differential equations such as MHD.

  11. Is it growing exponentially fast? -- Impact of assuming exponential growth for characterizing and forecasting epidemics with initial near-exponential growth dynamics.

    Science.gov (United States)

    Chowell, Gerardo; Viboud, Cécile

    2016-10-01

    The increasing use of mathematical models for epidemic forecasting has highlighted the importance of designing models that capture the baseline transmission characteristics in order to generate reliable epidemic forecasts. Improved models for epidemic forecasting could be achieved by identifying signature features of epidemic growth, which could inform the design of models of disease spread and reveal important characteristics of the transmission process. In particular, it is often taken for granted that the early growth phase of different growth processes in nature follow early exponential growth dynamics. In the context of infectious disease spread, this assumption is often convenient to describe a transmission process with mass action kinetics using differential equations and generate analytic expressions and estimates of the reproduction number. In this article, we carry out a simulation study to illustrate the impact of incorrectly assuming an exponential-growth model to characterize the early phase (e.g., 3-5 disease generation intervals) of an infectious disease outbreak that follows near-exponential growth dynamics. Specifically, we assess the impact on: 1) goodness of fit, 2) bias on the growth parameter, and 3) the impact on short-term epidemic forecasts. Designing transmission models and statistical approaches that more flexibly capture the profile of epidemic growth could lead to enhanced model fit, improved estimates of key transmission parameters, and more realistic epidemic forecasts.

  12. Contribution of mono-exponential, bi-exponential and stretched exponential model-based diffusion-weighted MR imaging in the diagnosis and differentiation of uterine cervical carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Meng; Yu, Xiaoduo; Chen, Yan; Ouyang, Han; Zhou, Chunwu [Chinese Academy of Medical Sciences, Department of Diagnostic Radiology, Cancer Institute and Hospital, Peking Union Medical College, Beijing (China); Wu, Bing; Zheng, Dandan [GE MR Research China, Beijing (China)

    2017-06-15

    To investigate the potential of various metrics derived from mono-exponential model (MEM), bi-exponential model (BEM) and stretched exponential model (SEM)-based diffusion-weighted imaging (DWI) in diagnosing and differentiating the pathological subtypes and grades of uterine cervical carcinoma. 71 newly diagnosed patients with cervical carcinoma (50 cases of squamous cell carcinoma [SCC] and 21 cases of adenocarcinoma [AC]) and 32 healthy volunteers received DWI with multiple b values. The apparent diffusion coefficient (ADC), pure molecular diffusion (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), water molecular diffusion heterogeneity index (alpha), and distributed diffusion coefficient (DDC) were calculated and compared between tumour and normal cervix, among different pathological subtypes and grades. All of the parameters were significantly lower in cervical carcinoma than normal cervical stroma except alpha. SCC showed lower ADC, D, f and DDC values and higher D* value than AC; D and DDC values of SCC and ADC and D values of AC were lower in the poorly differentiated group than those in the well-moderately differentiated group. Compared with MEM, diffusion parameters from BEM and SEM may offer additional information in cervical carcinoma diagnosis, predicting pathological tumour subtypes and grades, while f and D showed promising significance. (orig.)

  13. A new method to study changes in microvascular blood volume in muscle and adipose tissue: Real time imaging in humans and rat

    DEFF Research Database (Denmark)

    Sjøberg, Kim Anker; Rattigan, Stephen; Hiscock, Natalie J

    2011-01-01

    We employed and evaluated a new application of contrast enhanced ultrasound for real time imaging of changes in microvascular blood volume (MVB) in tissues in females, males and rat. Continuous real time imaging was performed using contrast enhanced ultrasound to quantify infused gas filled micro...

  14. An assessment of uncertainties in using volume-area modelling for computing the twenty-first century glacier contribution to sea-level change

    NARCIS (Netherlands)

    Slangen, A.B.A.; van de Wal, R.S.W.

    2011-01-01

    A large part of present-day sea-level change is formed by the melt of glaciers and ice caps (GIC). This study focuses on the uncertainties in the calculation of the GIC contribution on a century timescale. The model used is based on volume-area scaling, 5 combined with the mass balance sensitivity o

  15. New results on robust exponential stability of integral delay systems

    Science.gov (United States)

    Melchor-Aguilar, Daniel

    2016-06-01

    The robust exponential stability of integral delay systems with exponential kernels is investigated. Sufficient delay-dependent robust conditions expressed in terms of linear matrix inequalities and matrix norms are derived by using the Lyapunov-Krasovskii functional approach. The results are combined with a new result on quadratic stabilisability of the state-feedback synthesis problem in order to derive a new linear matrix inequality methodology of designing a robust non-fragile controller for the finite spectrum assignment of input delay systems that guarantees simultaneously a numerically safe implementation and also the robustness to uncertainty in the system matrices and to perturbation in the feedback gain.

  16. Exponential Lower Bounds and Separation for Query Rewriting

    CERN Document Server

    Kikot, Stanislav; Podolskii, Vladimir; Zakharyaschev, Michael

    2012-01-01

    We establish connections between the size of circuits and formulas computing monotone Boolean functions and the size of first-order and nonrecursive Datalog rewritings for conjunctive queries over OWL 2 QL ontologies. We use known lower bounds and separation results from circuit complexity to prove similar results for the size of rewritings that do not use non-signature constants. For example, we show that, in the worst case, positive existential and nonrecursive Datalog rewritings are exponentially longer than the original queries; nonrecursive Datalog rewritings are in general exponentially more succinct than positive existential rewritings; while first-order rewritings can be superpolynomially more succinct than positive existential rewritings.

  17. Real-Time Exponential Curve Fits Using Discrete Calculus

    Science.gov (United States)

    Rowe, Geoffrey

    2010-01-01

    An improved solution for curve fitting data to an exponential equation (y = Ae(exp Bt) + C) has been developed. This improvement is in four areas -- speed, stability, determinant processing time, and the removal of limits. The solution presented avoids iterative techniques and their stability errors by using three mathematical ideas: discrete calculus, a special relationship (be tween exponential curves and the Mean Value Theorem for Derivatives), and a simple linear curve fit algorithm. This method can also be applied to fitting data to the general power law equation y = Ax(exp B) + C and the general geometric growth equation y = Ak(exp Bt) + C.

  18. AN EXPONENTIAL INEQUALITY FOR AUTOREGRESSIVE PROCESSES IN ADAPTIVE TRACKING

    Institute of Scientific and Technical Information of China (English)

    Bernard BERCU

    2007-01-01

    A wide range of literature concerning classical asymptotic properties for linear models with adaptive control is available, such as strong laws of large numbers or central limit theorems.Unfortunately, in contrast with the situation without control, it appears to be impossible to find sharp asymptotic or nonasymptotic properties such as large deviation principles or exponential inequalities.Our purpose is to provide a first step towards that direction by proving a very simple exponential inequality for the standard least squares estimator of the unknown parameter of Gaussian autoregressive process in adaptive tracking.

  19. Exponential stability for uncertain neutral systems with Markov jumps

    Institute of Scientific and Technical Information of China (English)

    Shuping HE; Fei LIU

    2009-01-01

    This paper deals with the global exponential stability problems for stochastic neutral Markov jump sys-tems(MJSs) with uncertain parameters and multiple time-delays,The delays are respectively considered as constant and time varying cases,and the uncertainties are assumed to be norm bounded.By selecting appropriate Lyapunov-Krasovskii functions,it gives the sufficient condition such that the uncertain neutral MJSs are globally exponentially stochastically stable for all admissible uncertainties.The stability criteria are formulated in the form of linear matrix inequalities(LMIs),which can be easily checked in practice.Finally,two numerical examples are exploited to illustrate the effectiveness of the developed techniques.

  20. THE ROC CURVE MODEL FROM GENERALIZED-EXPONENTIAL DISTRIBUTION

    Directory of Open Access Journals (Sweden)

    Ehtesham Hussain

    2011-04-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 In biomedical studies often yield continuously positively skewed (non- normal distributed data. In this regard Generalized-Exponential Distribution is suggested for analyzing such data. In this paper the parametric equation of  the Receiving Operating Characteristic (ROC curve model is established under the assumptions of bi-distributional population based on pair of Generalized-Exponential Distributions. Also its maximum likelihood estimator MLE, sampling distribution , equivalence test statistic and exact confidence interval are derived.