Sample records for volume change caused

  1. Airborne laser quantification of Florida shoreline and beach volume change caused by hurricanes (United States)

    Robertson, William, V.

    This dissertation combines three separate studies that measure coastal change using airborne laser data. The initial study develops a method for measuring subaerial and subaqueous volume change incrementally alongshore, and compares those measurements to shoreline change in order to quantify their relationship in Palm Beach County, Florida. A poor correlation (R2 = 0.39) was found between shoreline and volume change before the hurricane season in the northern section of Palm Beach County because of beach nourishment and inlet dynamics. However, a relatively high R2 value of 0.78 in the southern section of Palm Beach County was found due to little disturbance from tidal inlets and coastal engineering projects. The shoreline and volume change caused by the 2004 hurricane season was poorly correlated with R 2 values of 0.02 and 0.42 for the north and south sections, respectively. The second study uses airborne laser data to investigate if there is a significant relationship between shoreline migration before and after Hurricane Ivan near Panama City, Florida. In addition, the relationship between shoreline change and subaerial volume was quantified and a new method for quantifying subaqueous sediment change was developed. No significant spatial relationship was found between shoreline migration before and after the hurricane. Utilization of a single coefficient to represent all relationships between shoreline and subaerial volume change was found to be problematic due to the spatial variability in the linear relationship. Differences in bathymetric data show only a small portion of sediment was transported beyond the active zone and most sediment remained within the active zone despite the occurrence of a hurricane. The third study uses airborne laser bathymetry to measure the offshore limit of change, and compares that location with calculated depth of closures and subaqueous geomorphology. There appears to be strong geologic control of the depth of closure in

  2. Expiratory computed tomographic techniques: a cause of a poor rate of change in lung volume. (United States)

    Morikawa, Keiko; Okada, Fumito; Mori, Hiromu


    Ninety-nine patients (29 males and 70 females; mean age, 57.1 years; range, 22-81 years) were included in this study to evaluate the factors affecting smaller lung volume changes in expiratory high-resolution computed tomography performed to depict air trapping. All patients underwent inspiratory and expiratory chest thin-section CT examinations and pulmonary function tests. Air trapping on CT images was graded subjectively. All variables (age, sex, diagnosis, pulmonary function index, and air trapping score) were compared with the degree of change in lung volume between the inspiratory and expiratory CT examinations. The variables affecting a lower degree of volume change were vital capacity, forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1.0), and the FEV1.0/FVC ratio. Bronchiolitis obliterans was the dominant diagnosis in patients with insufficient degrees of breath holding and in patients with negative air trapping scores despite an abnormal air trapping index. An insufficient degree of lung changes between inspiration and expiration on CT examinations represented bronchiolitis obliterans, which resulted in low FEV1.0 and FEV1.0/FVC values. Changes in the time gap from the announcement of exhalation and breath holding to the start of scanning most effectively indicated air trapping in patients with bronchiolar disorders.

  3. Early changes of volume and spatial location in target and normal tissues caused by IMRT for cervical cancer. (United States)

    Chen, Jianwu; Liu, Ping; Chen, Wenjuan; Bai, Penggang; Li, Jiangshan; Ni, Xiaolei; Chen, Kaiqiang; Li, Qixin


    To investigate the early changes of volume and spatial location in target and normal tissues caused by intensity-modulated radiotherapy (IMRT) for cervical cancer. Forty patients with cervical cancer were included in this study and treated by IMRT. Computed tomography (CT) was performed before radiotherapy and when the patient had received 27 Gy in 15 fractions. After image registration, the volume of interest (VOI) for the targets and organs at risk was delineated by clinicians on the CT images. Changes of volume, spatial location and Dice similarity were calculated for all VOIs. There were significant changes in gross tumor volume (GTV) in the primary tumor (GTV-T) with t = 8.304 (p<0.01) and visible pelvic lymph nodes (GTV-N) with t = 4.996 (p<0.01) caused by IMRT. The mean volume differences for GTV-T and GTV-N were 38.64% ± 19.50% (range 3.16%-86.49%) and 42.49% ± 25.68% (range 2.79%-87.42%), respectively. Among the organs at risk, the bladder had the greatest volume change with 55.13% ± 33.40% (range 3.25%-116.01%). The Dice similarity for GTV-T and GTV-N was 0.50 ± 0.18 (range 0.10-0.85) and 0.31 ± 0.20 (range 0.00-0.71), respectively. The rectum had the least Dice similarity among the normal tissues, with a mean value of 0.57 ± 0.14 (range 0.18-0.76). There were significant changes in volume and spatial location of the target and normal tissues after 27 Gy IMRT. In order to maintain the radiation dose to the targets and minimize the radiation to normal tissues, it is necessary to modify the radiotherapy planning.

  4. Biochemical kinetics in changing volumes. (United States)

    Pawłowski, Piotr H; Zielenkiewicz, Piotr


    The need of taking into account the change of compartment volume when developing chemical kinetics analysis inside the living cell is discussed. Literature models of a single enzymatic Michaelis-Menten process, glycolytic oscillations, and mitotic cyclin oscillations were tested with appropriate theoretical extension in the direction of volume modification allowance. Linear and exponential type of volume increase regimes were compared. Due to the above, in a growing cell damping of the amplitude, phase shift, and time pattern deformation of the metabolic rhythms considered were detected, depending on the volume change character. The performed computer simulations allow us to conclude that evolution of the cell volume can be an essential factor of the chemical kinetics in a growing cell. The phenomenon of additional metabolite oscillations caused by the periodic cell growth and division was theoretically predicted and mathematically described. Also, the hypothesis of the periodized state in the growing cell as the generalization of the steady-state was formulated.

  5. Plasma volume changes during hypoglycaemia

    DEFF Research Database (Denmark)

    Hilsted, J; Frandsen, Henrik Lund; Christensen, N J


    -induced hypoglycaemia with total autonomic blockade (alpha-adrenoceptor blockade combined with beta-adrenoceptor blockade and atropine); and insulin-induced hypoglycaemia without any autonomic blockade. In the experiments without autonomic blockade the peripheral venous hematocrit increased, plasma volume decreased......, intravascular albumin content decreased and the transcapillary escape rate of albumin increased. In both experiments with autonomic blockade the increase in venous haematocrit was abolished, yet plasma volume decreased, intravascular albumin content decreased and the transcapillary escape rate of albumin...... increased in these experiments. Thus, the changes in plasma volume and composition in response to hypoglycaemia are due to the combined actions of adrenaline and of insulin....

  6. Plasma volume changes during hypoglycaemia

    DEFF Research Database (Denmark)

    Hilsted, J; Bendtsen, F; Christensen, N J


    To investigate whether previously reported changes in venous blood volume and composition induced by acute hypoglycaemia in humans are representative for the entire body we measured erythrocyte 51Cr content, haematocrit, plasma volume, intravascular albumin content and transcapillary escape rate...... of albumin in arterial and venous blood in seven healthy subjects before and during insulin-induced hypoglycaemia. In both vascular sites blood 51Cr content and the haematocrit increased, plasma volume and intravascular albumin content decreased and the transcapillary escape rate of albumin increased during...


    Directory of Open Access Journals (Sweden)

    Camelia Slave


    Full Text Available Present brings several environmental problems for people. Many of these are closely related, but by far the most important problem is the climate change. In the course of Earth evolution, climate has changed many times, sometimes dramatically. Warmer eras always replaced and were in turn replaced by glacial ones. However, the climate of the past almost ten thousand years has been very stable. During this period human civilization has also developed. In the past nearly 100 years - since the beginning of industrialization - the global average temperature has increased by approx. 0.6 ° C (after IPCC (Intergovernmental Panel on Climate Change, faster than at any time in the last 1000 years.

  8. Climate Change: Evidence and Causes (United States)

    Wolff, Eric


    The fundamentals of climate change are well established: greenhouse gases warm the planet; their concentrations in the atmosphere are increasing; Earth has warmed, and is going to continue warming with a range of impacts. This article summarises the contents of a recent publication issued by the UK's Royal Society and the US National Academy…

  9. Climate Change: Evidence and Causes (United States)

    Wolff, Eric


    The fundamentals of climate change are well established: greenhouse gases warm the planet; their concentrations in the atmosphere are increasing; Earth has warmed, and is going to continue warming with a range of impacts. This article summarises the contents of a recent publication issued by the UK's Royal Society and the US National Academy of…

  10. Climate Change: Evidence and Causes (United States)

    Wolff, Eric


    The fundamentals of climate change are well established: greenhouse gases warm the planet; their concentrations in the atmosphere are increasing; Earth has warmed, and is going to continue warming with a range of impacts. This article summarises the contents of a recent publication issued by the UK's Royal Society and the US National Academy of…

  11. Volume change theory for syringomyelia: A new perspective. (United States)

    Rai, Survendra Kumar Rajdeo; Rai, Pooja Survendra Kumar


    The etiopathogenesis of syringomyelia is still an enigma. The authors present a novel theory based on fluid dynamics at the craniovertebral (CV) junction to explain the genesis of syringomyelia (SM). The changes in volume of spinal canal, spinal cord, central canal and spinal subarachnoid space (SSS) in relation to the posterior fossa have been analysed, specifically during postural movements of flexion and extension. The effect of fluctuations in volume of spinal canal and its contents associated with cerebrospinal fluid (CSF) flow dynamics at the CV junction have been postulated to cause the origin and propagation of the syringomyelia. The relevant literature on the subject has been reviewed and the author's theory has been discussed. Volume of spinal canal in flexion is always greater than that in extension. Flexion of spine causes narrowing of the ventral subarachnoid space (SAS) and widening of dorsal SAS while extension causes reverse changes leading to fluid movement in dorsal spinal SAS in flexion and ventral spinal SAS in extension. Cervical and lumbar spinal region with maximum bulk hence maximum area and volume undergo maximum deformation during postural changes. SSS CSF is the difference between the volume of spinal canal and spinal cord, varies in flexion and extension which is compensated by changes in posterior fossa (CSF) volume in normal circumstances. Blocked SAS at foramen magnum donot permit spinal SAS CSF exchange which during postural changes is compensated by cavitatory/cystic (syrinx) change at locations in cervical and lumbar spine with propensity for maximum deformation. Augmentation of posterior fossa volume by decompression helps by normalization of this CSF exchange dynamics but immobilizing the spinal movement theoretically will cease any dynamic volume changes thereby minimizing the destructive influence of the fluid exchange on the cord. Thus, this theory strengthens the rational of treating patients by either methodology.

  12. Changes of pituitary gland volume in Kennedy disease. (United States)

    Pieper, C C; Teismann, I K; Konrad, C; Heindel, W L; Schiffbauer, H


    Kennedy disease is a rare X-linked neurodegenerative disorder caused by a CAG repeat expansion in the first exon of the androgen-receptor gene. Apart from neurologic signs, this mutation can cause a partial androgen insensitivity syndrome with typical alterations of gonadotropic hormones produced by the pituitary gland. The aim of the present study was therefore to evaluate the impact of Kennedy disease on pituitary gland volume under the hypothesis that endocrinologic changes caused by partial androgen insensitivity may lead to morphologic changes (ie, hypertrophy) of the pituitary gland. Pituitary gland volume was measured in sagittal sections of 3D T1-weighted 3T-MR imaging data of 8 patients with genetically proven Kennedy disease and compared with 16 healthy age-matched control subjects by use of Multitracer by a blinded, experienced radiologist. The results were analyzed by a univariant ANOVA with total brain volume as a covariant. Furthermore, correlation and linear regression analyses were performed for pituitary volume, patient age, disease duration, and CAG repeat expansion length. Intraobserver reliability was evaluated by means of the Pearson correlation coefficient. Pituitary volume was significantly larger in patients with Kennedy disease (636 [±90] mm(3)) than in healthy control subjects (534 [±91] mm(3)) (P = .041). There was no significant difference in total brain volume (P = .379). Control subjects showed a significant decrease in volume with age (r = -0.712, P = .002), whereas there was a trend to increasing gland volume in patients with Kennedy disease (r = 0.443, P = .272). Gland volume correlated with CAG repeat expansion length in patients (r = 0.630, P = .047). The correlation coefficient for intraobserver reliability was 0.94 (P pituitary volume that correlated with the CAG repeat expansion length. This could reflect hypertrophy as the result of elevated gonadotropic hormone secretion caused by the androgen receptor mutation with partial

  13. Forced migrations caused by climate change

    Directory of Open Access Journals (Sweden)

    Neven Tandarić


    Full Text Available The consequences of climate change are becoming more and more pronounced, causing various environmental and social changes. One of the major and globally most noticeable changes is the intensification of forced migration caused by climate change. Such forced migrants, due to international legislation that has no built-in criteria to regulate the status of refugees due to environmental reasons and also climate change, cannot achieve this status and are becoming a problem of the entire international community, leading to significant social, economic, political and cultural changes at a global scale.

  14. How does climate change cause extinction? (United States)

    Cahill, Abigail E; Aiello-Lammens, Matthew E; Fisher-Reid, M Caitlin; Hua, Xia; Karanewsky, Caitlin J; Ryu, Hae Yeong; Sbeglia, Gena C; Spagnolo, Fabrizio; Waldron, John B; Warsi, Omar; Wiens, John J


    Anthropogenic climate change is predicted to be a major cause of species extinctions in the next 100 years. But what will actually cause these extinctions? For example, will it be limited physiological tolerance to high temperatures, changing biotic interactions or other factors? Here, we systematically review the proximate causes of climate-change related extinctions and their empirical support. We find 136 case studies of climatic impacts that are potentially relevant to this topic. However, only seven identified proximate causes of demonstrated local extinctions due to anthropogenic climate change. Among these seven studies, the proximate causes vary widely. Surprisingly, none show a straightforward relationship between local extinction and limited tolerances to high temperature. Instead, many studies implicate species interactions as an important proximate cause, especially decreases in food availability. We find very similar patterns in studies showing decreases in abundance associated with climate change, and in those studies showing impacts of climatic oscillations. Collectively, these results highlight our disturbingly limited knowledge of this crucial issue but also support the idea that changing species interactions are an important cause of documented population declines and extinctions related to climate change. Finally, we briefly outline general research strategies for identifying these proximate causes in future studies.

  15. Quantifying Volume Changing Perturbations in a Wave Chaotic System

    CERN Document Server

    Taddese, Biniyam Tesfaye; Moglie, Franco; Antonsen, Thomas M; Ott, Edward; Anlage, Steven M


    A sensor was developed to quantitatively measure perturbations which change the volume of a wave chaotic cavity while leaving its shape intact. The sensors work in the time domain by using either scattering fidelity of the transmitted signals or the classical analog of the Loschmidt echo. The sensors were tested experimentally by inducing volume changing perturbations to a one cubic meter pseudo-integrable, real-world cavity. Perturbations which caused a volume change that is as small as 54 parts in a million were quantitatively measured. These results were obtained by using electromagnetic waves with a wavelength of about $5cm$, therefore, the sensor is sensitive to extreme sub-wavelength changes of the boundaries of a cavity. The experimental results were compared with Finite Difference Time Domain (FDTD) simulation results, and good agreement was found. Furthermore, the sensor was tested using a frequency domain approach on a numerical model of the star graph, which is a representative wave chaotic system....

  16. Enamel surface changes caused by hydrogen sulfide

    Directory of Open Access Journals (Sweden)

    Takao Yamaguchi


    Conclusions: Our findings suggested that H 2 S occurring inside the mouth causes changes to the crystal structure of the enamel surface that can lead to tooth wear, but that it does not diminish the effects of dental bonding in adhesive restorations.

  17. The Utilization of Remotely Sensed Data to Analyze the Estimated Volume of Pyroclastic Deposits and Morphological Changes Caused by the 2010-2015 Eruption of Sinabung Volcano, North Sumatra, Indonesia (United States)

    Yulianto, Fajar; Suwarsono; Sofan, Parwati


    In this research, remotely sensed data has been used to estimate the volume of pyroclastic deposits and analyze morphological changes that have resulted from the eruption of Sinabung volcano. Topographic information was obtained from these data and used for rapid mapping to assist in the emergency response. Topographic information and change analyses (pre- and syn- eruption) were conducted using digital elevation models (DEMs) for the period 2010-2015. Advanced spaceborne thermal emission and reflection radiometer (ASTER) global digital elevation model (GDEM) data from 2009 were used to generate the initial DEMs for the condition prior to the eruption of 2010. Satellite pour l'observation de la terre 6 (SPOT 6) stereo images acquired on 21 June 2015 and were used to make a DEM for that time. The results show that the estimated total volume of lava and pyroclastic deposits, produced during the period 2010 to mid-2015 is approximately 2.8 × 108 m3. This estimated volume of pyroclastic deposits can be used to predict the magnitude of future secondary lahar hazards, which are also related to the capacity of rivers in the area. Morphological changes are illustrated using cross-sectional analysis of the deposits, which are currently deposited to the east, southeast and south of the volcano. Such analyses can also help in forecasting the direction of the future flow hazards. The remote sensing and analysis methods used at Sinabung can also be applied at other volcanoes and to assess the threats of other types of hazards such as landslides and land subsidence.

  18. Volume Changes in Filled Rubber Under Uniaxial Cyclic Loading

    Directory of Open Access Journals (Sweden)

    Elina KAZINA


    Full Text Available Styrene-butadiene rubber, neat and filled with different silica content was investigated under uniaxial cyclic loading under a constant crosshead speed, with increasing deformation amplitude in subsequent loading cycles. Rubber was investigated in order to evaluate the reversibility of structure rearrangements, occurring in rubber when subjected to cyclic loading. Volume uniformly increases with growing strain and shows hysteresis at unloading. After complete unloading, no residual strain changes are observed. These data are in good conformity with the data of density measurements, which were made on specimens before and after the tests. By correlating data, obtained from volume changes and kinetics of hysteresis losses there were made assumptions on deformation mechanisms at different elongations. Deformational mechanisms, responsible for volume changes in rubber are reversible. Volume changes in specimen occur due to voids formation caused by filler microstructure breakage, rubber chains disentanglement, spaces between rubber macromolecular chains shrinkage, and chain slippage under higher elongations. Voids formation and deformation of rubber macromolecular chain reaches equilibrium state after certain elongation.

  19. Causes for contemporary regional sea level changes. (United States)

    Stammer, Detlef; Cazenave, Anny; Ponte, Rui M; Tamisiea, Mark E


    Regional sea level changes can deviate substantially from those of the global mean, can vary on a broad range of timescales, and in some regions can even lead to a reversal of long-term global mean sea level trends. The underlying causes are associated with dynamic variations in the ocean circulation as part of climate modes of variability and with an isostatic adjustment of Earth's crust to past and ongoing changes in polar ice masses and continental water storage. Relative to the coastline, sea level is also affected by processes such as earthquakes and anthropogenically induced subsidence. Present-day regional sea level changes appear to be caused primarily by natural climate variability. However, the imprint of anthropogenic effects on regional sea level-whether due to changes in the atmospheric forcing or to mass variations in the system-will grow with time as climate change progresses, and toward the end of the twenty-first century, regional sea level patterns will be a superposition of climate variability modes and natural and anthropogenically induced static sea level patterns. Attribution and predictions of ongoing and future sea level changes require an expanded and sustained climate observing system.

  20. Apparatus for determining changes in limb volume (United States)

    Bhagat, P. K.; Wu, V. C. (Inventor)


    Measuring apparatus for determining changes in the volume of limbs or other boty extremities by determining the cross-sectional area of such limbs many comprise a transmitter including first and second transducers for positioning on the surface of the limb at a predetermined distance there between, and a receiver including a receiver crystal for positioning on the surface of the limb. The distance between the receiver crystal and the first and second transducers are represented by respective first and second chords of the cross-section of the limb and the predetermined distance between the first and second transducers is represented by a third chord of the limb cross section.

  1. Collapsibility and Volume Change Behavior of Unsaturated Residual Soil

    Directory of Open Access Journals (Sweden)

    Azalan A. Aziz


    Full Text Available Residual soils occur in most countries of the world but the greater areas and depths are normally found in tropical humid areas. In these places, the soil forming processes are still very active and the weathering development is much faster than the erosive factor. Most residual soil exhibit high suctions for most of the year. The absence of positive pore water pressure except immediately after rain, makes conventional soil mechanics for saturated soil not so relevant. Ignorance or lack of understanding of the geotechnical behavior of soil in the partially or unsaturated state has caused a lot of damages to infrastructures, buildings and other structures. For instance, the collapsibility and volume change of partially saturated soils in connection with the drying or wetting causes a lot of damage in foundation, roads and other structures. It is also observed that many shallow slope failures involve a slumping (collapse type of failure. As such, the development of extended soil mechanics, which embraces the soil in the unsaturated state or subjected to soil suction, is essential. This study examines the collapsibility and volume change behavior specifically of an unsaturated residual soil under various levels of applied matric suction (ua-uw and net mean stress (σ-ua in a predetermined stress path. The volume change of the soil is found to be sensitive to both the applied matric suction and net mean stress. The soil is found to exhibit a collapsibility behavior upon a reduction in applied matric suction at constant net mean stress.

  2. Heritable change caused by transient transcription errors.

    Directory of Open Access Journals (Sweden)

    Alasdair J E Gordon


    Full Text Available Transmission of cellular identity relies on the faithful transfer of information from the mother to the daughter cell. This process includes accurate replication of the DNA, but also the correct propagation of regulatory programs responsible for cellular identity. Errors in DNA replication (mutations and protein conformation (prions can trigger stable phenotypic changes and cause human disease, yet the ability of transient transcriptional errors to produce heritable phenotypic change ('epimutations' remains an open question. Here, we demonstrate that transcriptional errors made specifically in the mRNA encoding a transcription factor can promote heritable phenotypic change by reprogramming a transcriptional network, without altering DNA. We have harnessed the classical bistable switch in the lac operon, a memory-module, to capture the consequences of transient transcription errors in living Escherichia coli cells. We engineered an error-prone transcription sequence (A9 run in the gene encoding the lac repressor and show that this 'slippery' sequence directly increases epigenetic switching, not mutation in the cell population. Therefore, one altered transcript within a multi-generational series of many error-free transcripts can cause long-term phenotypic consequences. Thus, like DNA mutations, transcriptional epimutations can instigate heritable changes that increase phenotypic diversity, which drives both evolution and disease.

  3. Estimating the rates of mass change, ice volume change and snow volume change in Greenland from ICESat and GRACE data

    NARCIS (Netherlands)

    Slobbe, D.C.; Ditmar, P.G.; Lindenbergh, R.C.


    The focus of this paper is on the quantification of ongoing mass and volume changes over the Greenland ice sheet. For that purpose, we used elevation changes derived from the Ice, Cloud, and land Elevation Satellite (ICESat) laser altimetry mission and monthly variations of the Earth’s gravity field

  4. Human choice and climate change. Volume 2: Resources and technology

    Energy Technology Data Exchange (ETDEWEB)

    Raynor, S.; Malone, E. [eds.] [Pacific Northwest National Lab., Richland, WA (United States)


    This book is Volume 2 of a four-volume set which assesses social science research that is relevant to global climate change from a wide-ranging interdisciplinary perspective. Attention is focused on resources and technology as they relate to climate change. This series is indispensable reading for scientists and engineers wishing to make an effective contribution to the climate change policy debate.

  5. Asymptomatic cardiopulmonary changes caused by adenoid hypertrophy. (United States)

    Abdel-Aziz, Mosaad


    Adenoid hypertrophy is the most common cause of pediatric upper airway obstruction, and it can lead to cardiopulmonary complications such as pulmonary hypertension, cor pulmonale, and even heart failure. The aim of this study was to detect the asymptomatic cardiopulmonary changes that could happen in children with adenoid hypertrophy.Eighty children with adenoid hypertrophy were included in this study. Chest x-ray was used to assess the cardiothoracic ratio, whereas echocardiography was used for measuring the pulmonary arterial pressures, right ventricular diastolic filling parameters, and right ventricular end-diastolic diameters. All patients underwent adenoidectomy with or without tonsillectomy, and they were subjected again to echocardiographic assessment 6 months after the operation. No patient showed an increase in the cardiothoracic ratio on x-ray. Preoperative echocardiography showed an increase in pulmonary artery pressure (22.7 [SD, 3.8] mm Hg), a decrease in right ventricular diastolic filling parameters (E/A = 1.03 [SD, 0.17]), and an increase in right ventricular end-diastolic diameters (1.89 [SD, 0.19] cm). Postoperatively, pulmonary artery pressure decreased to 17.2 [SD, 2.1] mm Hg, right ventricular diastolic filling (E/A) increased to 1.25 [SD, 0.11], and right ventricular end-diastolic diameters decreased to 1.68 [SD, 0.12] cm. The comparison between preoperative and postoperative results for each individual parameter was statistically significant. Clinically asymptomatic cardiopulmonary changes due to adenoid hypertrophy are not rare. Early diagnosis and treatment of upper airway obstruction can prevent these serious complications. Echocardiographic examination should be recommended for these patients as a part of preoperative preparation to avoid anesthetic complications.

  6. Power law cross-correlations between price change and volume change of Indian stocks (United States)

    Hasan, Rashid; Mohammed Salim, M.


    We study multifractal long-range correlations and cross-correlations of daily price change and volume change of 50 stocks that comprise Nifty index of National Stock Exchange, Mumbai, using MF-DFA and MF-DCCA methods. We find that the time series of price change are uncorrelated, whereas anti-persistent long-range multifractal correlations are found in volume change series. We also find antipersistent long-range multifractal cross-correlations between the time series of price change and volume change. As multifractality is a signature of complexity, we estimate complexity parameters of the time series of price change, volume change, and cross-correlated price-volume change by fitting the fourth-degree polynomials to their multifractal spectra. Our results indicate that the time series of price change display high complexity, whereas the time series of volume change and cross-correlated price-volume change display low complexity.

  7. If this argument is true: Hashimotos disease causes chronic thyroid damage so in diseased elderly population the thyroid volumes must be low-retrospective US study

    Directory of Open Access Journals (Sweden)

    Betul Tiryaki Bastug


    Conclusions: The results have suggested that while aging although disease causes chronic thyroid damage, volume measurements do not change. Because volume reduction due to chronic damage of disease is balanced by volume increase due to aging. [Int J Res Med Sci 2016; 4(5.000: 1433-1437

  8. Resistance to change causes and solutions. (United States)

    Curtis, Elizabeth; White, Patricia


    CHANGE IN healthcare occurs at a rapid pace and all nurses, whatever their grade, must be knowledgeable and skilled in the change process ( White 1998 ). Reasons for change include restructuring in the workplace, advances in technology, a greater need for efficiency and the growth of new services ( White 1998 ).

  9. Residual limb volume change: Systematic review of measurement and management

    Directory of Open Access Journals (Sweden)

    Joan E. Sanders, PhD


    Full Text Available Management of residual limb volume affects decisions regarding timing of fit of the first prosthesis, when a new prosthetic socket is needed, design of a prosthetic socket, and prescription of accommodation strategies for daily volume fluctuations. This systematic review assesses what is known about measurement and management of residual limb volume change in persons with lower-limb amputation. Publications that met inclusion criteria were grouped into three categories: group I: descriptions of residual limb volume measurement techniques; group II: studies investigating the effect of residual limb volume change on clinical care in people with lower-limb amputation; and group III: studies of residual limb volume management techniques or descriptions of techniques for accommodating or controlling residual limb volume. We found that many techniques for the measurement of residual limb volume have been described but clinical use is limited largely because current techniques lack adequate resolution and in-socket measurement capability. Overall, limited evidence exists regarding the management of residual limb volume, and the evidence available focuses primarily on adults with transtibial amputation in the early postoperative phase. While we can draw some insights from the available research about residual limb volume measurement and management, further research is required.

  10. Age-dependent changes in mitochondrial morphology and volume are not predictors of lifespan. (United States)

    Regmi, Saroj G; Rolland, Stéphane G; Conradt, Barbara


    Mitochondrial dysfunction is a hallmark of skeletal muscle degeneration during aging. One mechanism through which mitochondrial dysfunction can be caused is through changes in mitochondrial morphology. To determine the role of mitochondrial morphology changes in age-dependent mitochondrial dysfunction, we studied mitochondrial morphology in body wall muscles of the nematodeC. elegans. We found that in this tissue, animals display a tubular mitochondrial network, which fragments with increasing age. This fragmentation is accompanied by a decrease in mitochondrial volume. Mitochondrial fragmentation and volume loss occur faster under conditions that shorten lifespan and occur slower under conditions that increase lifespan. However, neither mitochondrial morphology nor mitochondrial volume of five- and seven-day old wild-type animals can be used to predict individual lifespan. Our results indicate that while mitochondria in body wall muscles undergo age-dependent fragmentation and a loss in volume, these changes are not the cause of aging but rather a consequence of the aging process.

  11. Causes of Lexical Change of English Words

    Institute of Scientific and Technical Information of China (English)



      As is wel known, English is an international language. For the changing of time, the development of science and technology and the evolution of mind, the language which is the reflection of reality should keep pace with the development of the society accordingly. Therefore, facing so many and complicated English words, a language learner can do nothing but to grasp the reasons of its development in order to learn English words bet er. This paper seeks to focus on the two main reasons of the lexical change of English words.

  12. A volume change index for forest growth and sustainability (United States)

    Paul Van Deusen; Francis Roesch


    A volume change index is suggested that is derived from growth components that can be estimated from remeasured plots. The new index incorporates more information than the traditional growth over removals, ratio. The new index directly indicates whether the standing volume will be increasing or decreasing if current conditions persist, whereas the ratio of...

  13. Does Education Cause Spiritual Belief Change? (United States)

    Markle, D. Thomas


    Currently, little is known about the influence classroom learning has on the spiritual beliefs of students. Despite this fact, decisions on educational policy, parental home schooling, and even whether to bring legal actions against school districts, often rest on the assumption that education can induce spiritual belief change. To begin the…

  14. Preventing disasters caused by climatic change

    Institute of Scientific and Technical Information of China (English)


    @@ China is one of the countries that are often badly hit by climate-related disasters. To address the ever greater frequency of such disasters, a result of the unequivocal trend of global warming, the Chinese government should step up efforts and take strategic measures, suggests a panel of the CAS Academic Divisions in a consultative report concerning the impact of climatic change on China.

  15. Climate change: Causes, effects and mitigation measures- A review ...

    African Journals Online (AJOL)

    Climate change: Causes, effects and mitigation measures- A review. ... far more than at any time in the last 650,000 years resulting in climate change or global warming. ... loss of biodiversity, food insecurity, decreased animal health et cetera.

  16. Environmental law and climate change : Volumes I & II

    NARCIS (Netherlands)

    Verschuuren, Jonathan


    Two volume set that brings together 54 of the most influential and important scientific journal articles in the field of climate law, thematically grouped together as follows: introducing climate law, theories and approaches, climate change mitigation, climate change adaptation, climate justice, lia

  17. Pituitary volumes are changed in patients with conversion disorder. (United States)

    Atmaca, Murad; Baykara, Sema; Mermi, Osman; Yildirim, Hanefi; Akaslan, Unsal


    Our study group previously measured pituitary volumes and found a relationship between somatoform disoders and pituitary volumes. Therefore, in conversion disorder, another somatoform disorder, we hypothesized that pituitary gland volumes would be reduced. Twenty female patients and healthy controls were recruited to the present investigation. The volumes of the pituitary gland were determined by using a 1.5 Tesla magnetic resonance scanner. We found that the pituitary gland volumes of the patients with conversion disorder were significantly smaller than those of healthy control subjects. In the patients with conversion disorder but not in the healthy control group, a significant negative correlation between the duration of illness and pituitary gland volume was determined. In summary, in the present study, we suggest that the patients with conversion disorder have smaller pituitary volumes compared to those of healthy control subjects. Further studies should confirm our data and ascertain whether volumetric alterations determined in the patients with conversion disorder can be changed with treatment or if they change over time.

  18. Experimental Study on Volume Change Indices of Bentonite Soils

    Institute of Scientific and Technical Information of China (English)


    This paper reports experimental results regarding statically compacted clay specimens to study the volume change behavior of bentonites. The volume change indices such as the coefficients of compressibility, volume compressibility, and consolidation ( i. e.av , mv and cv respectively) and the saturated coefficient of permeability k at different surcharge pressures were determined with the commonly adopted procedures. The swell potentials, swelling pressures, different phases of the swollen specimens were analyzed for the volume change behavior during compression. Experimental results revealed that the swell potential is dependent on the initial dry density, the initial water content and the vertical pressure at which the clay specimens were allowed to swell. The swelling pressure was found to be similar for the specimens with varying water content, showing strong dependency on the initial void ratio. The compression indices ( viz. mv and av) of saturated specimens decreased with an increase in the vertical pressure. About 80% to 90% of the volume change occurred in the primary compression phase under any given vertical pressure. The coefficient of consolidation cv and the saturated coefficient of permeability k decreased with an increase in the vertical pressure.

  19. Epidural anesthesia, hypotension, and changes in intravascular volume

    DEFF Research Database (Denmark)

    Holte, Kathrine; Foss, Nicolai B; Svensén, Christer


    BACKGROUND: The most common side effect of epidural or spinal anesthesia is hypotension with functional hypovolemia prompting fluid infusions or administration of vasopressors. Short-term studies (20 min) in patients undergoing lumbar epidural anesthesia suggest that plasma volume may increase when...... hypotension is present, which may have implications for the choice of treatment of hypotension. However, no long-term information or measurements of plasma volumes with or without hypotension after epidural anesthesia are available. METHODS: In 12 healthy volunteers, the authors assessed plasma (125I...... receiving hydroxyethyl starch. RESULTS: Plasma volume did not change per se after thoracic epidural anesthesia despite a decrease in blood pressure. Plasma volume increased with fluid administration but remained unchanged with vasopressors despite that both treatments had similar hemodynamic effects...

  20. Causes of Resistance to Change. What Managers Should Do?

    Directory of Open Access Journals (Sweden)

    Ion Stegaroiu


    Full Text Available Change is considered, in more and more cases, an inevitable process and the development of an organization largely depends on how it reacts and adapts to transformations occurring. Change has both positive and negative aspects, it implies experiment and creation of something new and different, but it also means destruction of familiar facts and relationships. The implementation failure rate of organizational change remains high and one of the most common causes of this is considered to be the resistance to change. Although the resistance to change is considered a natural reaction, it is necessary to understand the causes and identify the measures for its reduction. Using content analysis of representative works, as a research method, we identified a number of factors that cause resistance to change and methods than can be used to decrease it, in order to successful implement the organizational change. Journal:Risk in the Contemporary Economy, Proceedings Conference

  1. Hydrological Changes of the Irtysh River and the Possible Causes

    NARCIS (Netherlands)

    Huang, F.; Xia, Z.; Li, F.; Guo, L.; Yang, F.


    Hydrological changes of the Irtysh River were analyzed concerning the changes of annual runoff and its distribution features within a year measured by coefficient of variation and concentration degree. Abrupt changes were detected by the heuristic segmentation method. Possible causes of the hydrolog

  2. KCNQ1 channels sense small changes in cell volume

    DEFF Research Database (Denmark)

    Grunnet, Morten; Jespersen, Thomas; MacAulay, Nanna


    . Incubation of the oocytes in cytochalasin D and experiments with truncated KCNQ1 channels suggest that KCNQ1 channels sense cell volume changes through interactions between the cytoskeleton and the N-terminus of the channel protein. From our results we propose that KCNQ1 and KCNQ4 channels play an important...

  3. Acute plasma volume change with high-intensity sprint exercise. (United States)

    Bloomer, Richard J; Farney, Tyler M


    When exercise is of long duration or of moderate to high intensity, a decrease in plasma volume can be observed. This has been noted for both aerobic and resistance exercise, but few data are available with regard to high-intensity sprint exercise. We measured plasma volume before and after 3 different bouts of acute exercise, of varying intensity, and/or duration. On different days, men (n = 12; 21-35 years) performed aerobic cycle exercise (60 minutes at 70% heart rate reserve) and 2 different bouts of cycle sprints (five 60-second sprints at 100% maximum wattage obtained during graded exercise testing (GXT) and ten 15-second sprints at 200% maximum wattage obtained during GXT). Blood was collected before and 0, 30, and 60 minutes postexercise and analyzed for hematocrit and hemoglobin and plasma volume was calculated. Plasma volume decreased significantly for all exercise bouts (p sprint bouts (∼19%) compared with aerobic exercise bouts (∼11%). By 30 minutes postexercise, plasma volume approached pre-exercise values. We conclude that acute bouts of exercise, in particular high-intensity sprint exercise, significantly decrease plasma volume during the immediate postexercise period. It is unknown what, if any negative implications these transient changes may have on exercise performance. Strength and conditioning professionals may aim to rehydrate athletes appropriately after high-intensity exercise bouts.

  4. English language diachronic morphologic change causes new point of view

    Directory of Open Access Journals (Sweden)

    Е В Бондаренко


    Full Text Available Any language is a systematic-structural organization. Its inner structure is characterized by having an ability to self-development. The self-organization theory offers new ideas of diachronic language change causes explanation. The English language morphological changes causes of early stages development must be thought of as a combination of inner language abilities to self-development and extra linguistic factors.

  5. Volume changes in glass induced by an electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Gavenda, Tadeáš, E-mail: [Department of Glass and Ceramics, Institute of Chemical Technology, Technická 5, CZ-166 28 Prague (Czech Republic); Gedeon, Ondrej [Department of Glass and Ceramics, Institute of Chemical Technology, Technická 5, CZ-166 28 Prague (Czech Republic); Jurek, Karel [Institute of Physics, Academy of the Czech Republic, Na Slovance 2, CZ-182 21 Prague (Czech Republic)


    Three glasses (float, borosilicate float and Schott D263 glasses) were irradiated by 50 keV electron beams with doses within the range of 0.21–318.5 kC/m{sup 2}. Volume changes induced by electron bombarding were monitored by means of Atomic Force Microscopy. Incubation doses, related to mobility of alkali ions, were measured. Low doses showed compaction of all glasses while higher doses revealed volume inflation, except for borosilicate float glass. Both surfaces of float glass were irradiated and significant differences between them were found.

  6. Volume changes in glass induced by an electron beam (United States)

    Gavenda, Tadeáš; Gedeon, Ondrej; Jurek, Karel


    Three glasses (float, borosilicate float and Schott D263 glasses) were irradiated by 50 keV electron beams with doses within the range of 0.21-318.5 kC/m2. Volume changes induced by electron bombarding were monitored by means of Atomic Force Microscopy. Incubation doses, related to mobility of alkali ions, were measured. Low doses showed compaction of all glasses while higher doses revealed volume inflation, except for borosilicate float glass. Both surfaces of float glass were irradiated and significant differences between them were found.

  7. Some comments on the possible causes of climate change

    CERN Document Server

    Padget, L


    Climate change is an important current issue and there is much debate about the causes and effects. This article examines the changes in our climate, comparing the recent changes with those in the past. There have been changes in temperature, resulting in an average global rise over the last 300 years, as well as widespread melting of snow and ice, and rising global average sea level. There are many theories for the causes of the recent change in the climate, including some natural and some human influenced. The most widely believed cause of the climate change is increasing levels of Greenhouse gases in the atmosphere and as the atmosphere plays an important role in making our planet inhabitable, it is important to understand it in order to protect it. However, there are other theories for the cause of climate change, the Sun and cosmic rays, for example, are felt by some to have a significant role to play. There is also well-established evidence that the three Milankovitch cycles change the amount and alter ...

  8. Density assumptions for converting geodetic glacier volume change to mass change

    Directory of Open Access Journals (Sweden)

    M. Huss


    Full Text Available The geodetic method is widely used for assessing changes in the mass balance of mountain glaciers. However, comparison of repeated digital elevation models only provides a glacier volume change that must be converted to a change in mass using a density assumption or model. This study investigates the use of a constant factor for the volume-to-mass conversion based on a firn compaction model applied to simplified glacier geometries with idealized climate forcing, and two glaciers with long-term mass balance series. It is shown that the "density" of geodetic volume change is not a constant factor and is systematically smaller than ice density in most cases. This is explained by the accretion/removal of low-density firn layers, and changes in the firn density profile with positive/negative mass balance. Assuming a value of 850 ± 60 kg m−3 to convert volume change to mass change is appropriate for a wide range of conditions. For short time intervals (≤3 yr, periods with limited volume change, and/or changing mass balance gradients, the conversion factor can however vary from 0–2000 kg m−3 and beyond, which requires caution when interpreting glacier mass changes based on geodetic surveys.

  9. Measurement of cell volume changes by fluorescence self-quenching

    DEFF Research Database (Denmark)

    Hamann, Steffen; Kiilgaard, J.F.; Litman, Thomas


    At high concentrations, certain fluorophores undergo self-quenching, i.e., fluorescence intensity decreases with increasing fluorophore concentration. Accordingly, the self-quenching properties can be used for measuring water volume changes in lipid vesicles. In cells, quantitative determination...... of water transport using fluorescence self-quenching has been complicated by the requirement of relatively high (mM) and often toxic loading concentrations. Here we report a simple method that uses low (muM) loading concentrations of calcein-acetoxymethyl ester (calcein-AM) to obtain intracellular...... concentrations of the fluorophore calcein suitable for measurement of changes in cell water volume by self-quenching. The relationship between calcein fluorescence intensity, when excited at 490 nm (its excitation maximum), and calcein concentration was investigated in vitro and in various cultured cell types...

  10. Impact of blood volume changes within the human skin on the diffuse reflectance measurements in visible and NIR spectral ranges (United States)

    Zherebtsov, Evgeny; Bykov, Alexander; Popov, Alexey; Doronin, Alexander; Meglinski, Igor


    We consider changes in the volume of blood and oxygen saturation caused by a pulse wave and their influence on the diffuse reflectance spectra in the visible/NIR spectral range. CUDA-based Monte-Carlo model was used for routine simulation of detector depth sensitivity (sampling volume) and skin spectra, and their variations associated with physiological changes in the human skin. The results presented in the form of animated graphs of sampling volume changes for scaling of the parameters of the main human skin layers related to the results of experimental measurements are of particular interest for pulse oximetry, photoplethysmography, Doppler flowmetry, reflectance spectroscopy.

  11. Sea Level Change: Is the Volume of the Ocean Changing or Is It Redistributing? (United States)

    Mitchum, G. T.; Thompson, P. R.; Merrifield, M. A.


    Global sea level change is due to changes in the ocean volume, which are in turn primarily due to changes in the globally averaged density of the ocean and ice melt from the land. Regional to local sea level changes reflect global changes as well as redistributions of volume due to ocean dynamics and land motions. Determining whether global sea level change is accelerating requires that we disentangle these regional and local signals from the true global volume changes. Given the current length of our time series determining acceleration is problematic, largely because of substantial spatial and temporal changes in the global sea level field due to ocean-atmosphere dynamics. We will review our work showing that global sea level reconstructions are sensitive to the weightings applied to the tide gauge data. We will also review basin-scale changes in sea level in the North Atlantic and the Tropical Pacific that are clearly wind-driven. These are important for two reasons. First, these signals mask the (presently) small global signal, and second, these signals present a statistical challenge for determining the acceleration of the global volume change rate. The obvious question is how well we can expect to estimate the sea level rise acceleration rate given the observed red noise character, in time and space, of the volume redistribution signals. We will end the presentation with various simulations of our ability to determine global sea level change acceleration that take into account reasonable estimates of decadal redistributions of ocean volume. The net result is that most recent attempts to determine acceleration are seriously flawed. On the positive side, we will provide estimates of how long it might take to make more reliable estimates.

  12. Density assumptions for converting geodetic glacier volume change to mass change

    Directory of Open Access Journals (Sweden)

    M. Huss


    Full Text Available The geodetic method is widely used for assessing changes in the mass balance of mountain glaciers. However, comparison of repeated digital elevation models only provides a glacier volume change that must be converted to a change in mass using a density assumption. This study investigates this conversion factor based on a firn compaction model applied to simplified glacier geometries with idealized climate forcing, and two glaciers with long-term mass balance series. It is shown that the "density" of geodetic volume change is not a constant factor and is systematically smaller than ice density in most cases. This is explained by the accretion/removal of low-density firn layers, and changes in the firn density profile with positive/negative mass balance. Assuming a value of 850 ± 60 kg m−3 to convert volume change to mass change is appropriate for a wide range of conditions. For short time intervals (≤3 yr, periods with limited volume change, and/or changing mass balance gradients, the conversion factor can however vary from 0–2000 kg m−3 and beyond which requires caution when interpreting glacier mass changes based on geodetic surveys.

  13. Changes in plasma volume and baroreflex function following resistance exercise (United States)

    Ploutz, L. L.; Tatro, D. L.; Dudley, G. A.; Convertino, V. A.


    The dynamics of change in plasma volume (PV) and baroreflex responses have been reported over 24 h immediately following maximal cycle exercise. The purpose of this study was to determine if PV and baroreflex showed similar changes for 24 h after resistance exercise. Eight men were studied on 2 test days, 1 week apart. On 1 day, per cent change (% delta) in PV was estimated at 0,3, and 6 h after resistance exercise using haematocrit and haemoglobin. Baseline PV was measured 24 h after exercise using Evans blue dye. The carotid baroreceptor-cardiac reflex response was measured before, and 3, 6, 9, 12, and 24 h post-exercise. Each subject performed six sets of the bench press and leg press with 10 repetitions per set with a load that induced failure within each set. On a control day, the protocol was used without exercise. Plasma volume did not change during the control day. There was a 20% decrease in PV immediately post-exercise; the recovery of the PV was rapid and complete within 3 h. PV was 20% greater 24 h post-exercise than on the control day. There were no differences in any of the baroreflex measurements. Therefore, it is suggested that PV shifts may occur without altering baroreflex sensitivity.

  14. Volume and enthalpy changes of proton transfers in the bacteriorhodopsin photocycle studied by millisecond time-resolved photopressure measurements. (United States)

    Liu, Yan; Edens, Gregory J; Grzymski, Joseph; Mauzerall, David


    The volume and enthalpy changes associated with proton translocation steps during the bacteriorhodopsin (BR) photocycle were determined by time-resolved photopressure measurements. The data at 25 degrees C show a prompt increase in volume followed by two further increases and one decrease to the original state to complete the cycle. These volume changes are decomposed into enthalpy and inherent volume changes. The positive enthalpy changes support the argument for inherent entropy-driven late steps in the BR photocycle [Ort, D. R., and Parson, W. M. (1979) Enthalpy changes during the photochemical cycle of bacteriorhodopsin. Biophys. J. 25, 355-364]. The volume change data can be interpreted by the electrostriction effect as charges are canceled and formed during the proton transfers. A simple glutamic acid-glutamate ion model or a diglutamate-arginine-protonated water charge-delocalized model for the proton-release complex (PRC) fit the data. A conformational change with a large positive volume change is required in the slower rise (M --> N of the optical cycle) step and is reversed in the decay (N --> O --> BR) steps. The large variation in the published values for both the volume and enthalpy changes is greatly ameliorated if the values are presented per absorbed photon instead of per mole of BR. Thus, it is the highly differing assumptions about the quantum or reaction yields that cause the variations in the published results.

  15. Listening to PS II: enthalpy, entropy, and volume changes. (United States)

    Hou, Harvey J M; Mauzerall, David


    Photosystem II, located in the thylakoid membranes of green plants, algae, and cyanobacteria, uses sunlight to split water into protons, electrons, and a dioxygen molecule. The mechanism of its electron transfers and oxygen evolution including the structure of the protein and rates of the S-state cycle has been extensively investigated. Substantial progress has been made; however, the thermodynamics of PS II electron transfer and of the oxygen cycle are poorly understood. Recent progress in thermodynamic measurements in photosynthesis provides novel insights on the enthalpic and entropic contribution to electron transfer in proteins. In this review the thermodynamic parameters including quantum yield, enthalpy, entropy, and volume changes of PS II photochemistry determined by photoacoustics and other laser techniques are summarized and evaluated. Light-driven volume changes via electrostriction are directly related to the photoreaction in PS II and thus can be a useful measurement of PS II activity and function. The enthalpy changes of the reactions observed can be directly measured by photoacoustics. The apparent reaction entropy can also be estimated when the free energy is known. Dissecting the free energy of a photoreaction into enthalpic and entropic components provides critical information about mechanisms of PS II function. Potential limitations and future direction of the study of the thermodynamics of PS II electron transfer and oxygen evolution are presented.

  16. Challenges in Accommodating Volume Change of Si Anodes for Li-Ion Batteries. (United States)

    Ko, Minseong; Chae, Sujong; Cho, Jaephil


    Si has been considered as a promising alternative anode for next-generation Li-ion batteries (LIBs) because of its high theoretical energy density, relatively low working potential, and abundance in nature. However, Si anodes exhibit rapid capacity decay and an increase in the internal resistance, which are caused by the large volume changes upon Li insertion and extraction. This unfortunately limits their practical applications. Therefore, managing the total volume change remains a critical challenge for effectively alleviating the mechanical fractures and instability of solid-electrolyte-interphase products. In this regard, we review the recent progress in volume-change-accommodating Si electrodes and investigate their ingenious structures with significant improvements in the battery performance, including size-controlled materials, patterned thin films, porous structures, shape-preserving shell designs, and graphene composites. These representative approaches potentially overcome the large morphologic changes in the volume of Si anodes by securing the strain relaxation and structural integrity in the entire electrode. Finally, we propose perspectives and future challenges to realize the practical application of Si anodes in LIB systems.

  17. Attitudes of common employees to the organizational changes and causes of worries and refusing changes


    Šťastná, Marie


    The thesis focuses on employees' attitudes to organizational changes, range of their possible reactions and models of organizational change implementation. This thesis aims at common employees and their view on the phenomenon of organizational change. The theoretical part presents the issue of organizational change, shows the basic types of changes and names the possible causes of changes. It also provides a short insight into the historical development of employees' position in organizations...

  18. Investigations of the changes in the bentonite structure caused by the different treatments

    Directory of Open Access Journals (Sweden)

    Stojiljković S.


    Full Text Available The bentonite was treated in different ways and the changes in structure were monitored. Acid activation with sulphuric acid of investigated bentonite caused the increase in specific volume of micropore-mesopore. It was shown that activation by acid obtained at a constant temperature and constant period of time provides the possibility to obtain samples of bentonite of searched porosity only by changing the concentration of sulphuric and hydrochloric acid. By thermal activation of bentonite clay in the temperature range 100-1100 0C, samples of desired porosity were acquired. [Projekat Ministarstva nauke Republike Srbije, br. 174007i br. TR 34020

  19. Moderate intensity supine exercise causes decreased cardiac volumes and increased outer volume variations: a cardiovascular magnetic resonance study

    DEFF Research Database (Denmark)

    Steding-Ehrenborg, Katarina; Jablonowski, Robert; Arvidsson, Per M;


    The effects on left and right ventricular (LV, RV) volumes during physical exercise remains controversial. Furthermore, no previous study has investigated the effects of exercise on longitudinal contribution to stroke volume (SV) and the outer volume variation of the heart. The aim of this study...

  20. Has solar variability caused climate change that affected human culture? (United States)

    Feynman, Joan

    If solar variability affects human culture it most likely does so by changing the climate in which the culture operates. Variations in the solar radiative input to the Earth's atmosphere have often been suggested as a cause of such climate change on time scales from decades to tens of millennia. In the last 20 years there has been enormous progress in our knowledge of the many fields of research that impinge on this problem; the history of the solar output, the effect of solar variability on the Earth's mean climate and its regional patterns, the history of the Earth's climate and the history of mankind and human culture. This new knowledge encourages revisiting the question asked in the title of this talk. Several important historical events have been reliably related to climate change including the Little Ice Age in northern Europe and the collapse of the Classical Mayan civilization in the 9th century AD. In the first section of this paper we discus these historical events and review the evidence that they were caused by changes in the solar output. Perhaps the most important event in the history of mankind was the development of agricultural societies. This began to occur almost 12,000 years ago when the climate changed from the Pleistocene to the modern climate of the Holocene. In the second section of the paper we will discuss the suggestion ( Feynman and Ruzmaikin, 2007) that climate variability was the reason agriculture developed when it did and not before.

  1. Aging-caused changes in optical anisotropy of fibrous tissues (United States)

    Mikhailova, Alyona D.; Ermolenko, Sergey B.; Zimnyakov, Dmitry A.; Angelsky, Oleg V.


    Energy density approach as a modification of the coherent potential approximation was applied to analyze the influence of aging-caused changes in the fibrous tissue on its birefringence. The real fibrous tissue such as tendon was modeled by disordered array of partially oriented dielectric cylinders illuminated by a normally incident linearly polarized plane wave. The supraspinatus human tendon was taken as an object for theoretical modeling. The morphological features of the studied tissue were considered for a system of collagen fiber bundles embedded in a carbohydrate matrix. The latter one is a mixture of glycosaminoglycans and proteoglycans. Age-caused changes of the fibers and matrix influence on the spectral dependence of optical anisotropy spectrum.

  2. Comparative changes in plasma protein concentration, hematocrit and plasma volume during exercise, bedrest and + Gz acceleration. (United States)

    Van Beaumont, W.; Greenleaf, J. E.


    Discussion of experiments which indicate that under conditions of a constant red cell volume the proportional changes in hematocrit and plasma volume during exercise are never equal. On the basis of direct measurements and calculated changes of plasma volume it is concluded that during maximal exercise there is a small loss of protein from the plasma. It is clear that changes in content of blood constituents can only be evaluated correctly after determination of changes in plasma volume.

  3. The causes of resistance to changes by teachers in schools

    Directory of Open Access Journals (Sweden)

    Gizem Gürses


    Full Text Available This study aims to determine the causes of resistance to changes by teachers who work at state elementary schools of Directorate of National Education in İzmir according to the views of teachers. This study was conducted as a survey and it is a descriptive study. The population of this study consists of 18770 teachers who work in 796 elementary schools in İzmir, districts and villages of İzmir during 2009-2010 education periods. The sample of this study consists of 750 teachers who work in 96 elementary schools chosen randomly in the same city center, districts and villages in İzmir. Research findings indicate that of the causes of resistance in elementary schools lack of knowledge about the process of change and unwillingness to get new duties, roles and responsibilities by the teachers is “moderate”. In addition, the research indicates that the resistance is “high” when it is related to the capacity deficiencies of the school and the resistance level is “low” when it is related to the fear of suffering from change and the schools administrators’ inability to manage the change.

  4. Beach Volume Change Using Uav Photogrammetry Songjung Beach, Korea (United States)

    Yoo, C. I.; Oh, T. S.


    Natural beach is controlled by many factors related to wave and tidal forces, wind, sediment, and initial topography. For this reason, if numerous topographic data of beach is accurately collected, coastal erosion/acceleration is able to be assessed and clarified. Generally, however, many studies on coastal erosion have limitation to analyse the whole beach, carried out of partial area as like shoreline (horizontal 2D) and beach profile (vertical 2D) on account of limitation of numerical simulation. This is an important application for prevention of coastal erosion, and UAV photogrammetry is also used to 3D topographic data. This paper analyses the use of unmanned aerial vehicles (UAV) to 3D map and beach volume change. UAV (Quadcopter) equipped with a non-metric camera was used to acquire images in Songjung beach which is located south-east Korea peninsula. The dynamics of beach topography, its geometric properties and estimates of eroded and deposited sand volumes were determined by combining elevation data with quarterly RTK-VRS measurements. To explore the new possibilities for assessment of coastal change we have developed a methodology for 3D analysis of coastal topography evolution based on existing high resolution elevation data combined with low coast, UAV and on-ground RTK-VRS surveys. DSMs were obtained by stereo-matching using Agisoft Photoscan. Using GCPs the vertical accuracy of the DSMs was found to be 10 cm or better. The resulting datasets were integrated in a local coordinates and the method proved to be a very useful fool for the detection of areas where coastal erosion occurs and for the quantification of beach change. The value of such analysis is illustrated by applications to coastal of South Korea sites that face significant management challenges.


    Directory of Open Access Journals (Sweden)

    C. I. Yoo


    Full Text Available Natural beach is controlled by many factors related to wave and tidal forces, wind, sediment, and initial topography. For this reason, if numerous topographic data of beach is accurately collected, coastal erosion/acceleration is able to be assessed and clarified. Generally, however, many studies on coastal erosion have limitation to analyse the whole beach, carried out of partial area as like shoreline (horizontal 2D and beach profile (vertical 2D on account of limitation of numerical simulation. This is an important application for prevention of coastal erosion, and UAV photogrammetry is also used to 3D topographic data. This paper analyses the use of unmanned aerial vehicles (UAV to 3D map and beach volume change. UAV (Quadcopter equipped with a non-metric camera was used to acquire images in Songjung beach which is located south-east Korea peninsula. The dynamics of beach topography, its geometric properties and estimates of eroded and deposited sand volumes were determined by combining elevation data with quarterly RTK-VRS measurements. To explore the new possibilities for assessment of coastal change we have developed a methodology for 3D analysis of coastal topography evolution based on existing high resolution elevation data combined with low coast, UAV and on-ground RTK-VRS surveys. DSMs were obtained by stereo-matching using Agisoft Photoscan. Using GCPs the vertical accuracy of the DSMs was found to be 10 cm or better. The resulting datasets were integrated in a local coordinates and the method proved to be a very useful fool for the detection of areas where coastal erosion occurs and for the quantification of beach change. The value of such analysis is illustrated by applications to coastal of South Korea sites that face significant management challenges.

  6. Bilingual Language Acquisition and Theories of Diachronic Change: Bilingualism as Cause and Effect of Grammatical Change (United States)

    Meisel, Jurgen M.


    Children acquiring their first languages are frequently regarded as the principal agents of diachronic change. The causes and the precise nature of the processes of change are, however, far from clear. The following discussion focuses on possible changes of core properties of grammars which, in terms of the theory of Universal Grammar, can be…

  7. Size and sequence and the volume change of protein folding. (United States)

    Rouget, Jean-Baptiste; Aksel, Tural; Roche, Julien; Saldana, Jean-Louis; Garcia, Angel E; Barrick, Doug; Royer, Catherine A


    The application of hydrostatic pressure generally leads to protein unfolding, implying, in accordance with Le Chatelier's principle, that the unfolded state has a smaller molar volume than the folded state. However, the origin of the volume change upon unfolding, ΔV(u), has yet to be determined. We have examined systematically the effects of protein size and sequence on the value of ΔV(u) using as a model system a series of deletion variants of the ankyrin repeat domain of the Notch receptor. The results provide strong evidence in support of the notion that the major contributing factor to pressure effects on proteins is their imperfect internal packing in the folded state. These packing defects appear to be specifically localized in the 3D structure, in contrast to the uniformly distributed effects of temperature and denaturants that depend upon hydration of exposed surface area upon unfolding. Given its local nature, the extent to which pressure globally affects protein structure can inform on the degree of cooperativity and long-range coupling intrinsic to the folded state. We also show that the energetics of the protein's conformations can significantly modulate their volumetric properties, providing further insight into protein stability.

  8. Comparison of gray matter volume and thickness for analysis of cortical changes in Alzheimer's disease (United States)

    Liu, Jiachao; Li, Ziyi; Chen, Kewei; Yao, Li; Wang, Zhiqun; Li, Kunchen; Guo, Xiaojuan


    Gray matter volume and cortical thickness are two indices of concern in brain structure magnetic resonance imaging research. Gray matter volume reflects mixed-measurement information of cerebral cortex, while cortical thickness reflects only the information of distance between inner surface and outer surface of cerebral cortex. Using Scaled Subprofile Modeling based on Principal Component Analysis (SSM_PCA) and Pearson's Correlation Analysis, this study further provided quantitative comparisons and depicted both global relevance and local relevance to comprehensively investigate morphometrical abnormalities in cerebral cortex in Alzheimer's disease (AD). Thirteen patients with AD and thirteen age- and gender-matched healthy controls were included in this study. Results showed that factor scores from the first 8 principal components accounted for ~53.38% of the total variance for gray matter volume, and ~50.18% for cortical thickness. Factor scores from the fifth principal component showed significant correlation. In addition, gray matter voxel-based volume was closely related to cortical thickness alterations in most cortical cortex, especially, in some typical abnormal brain regions such as insula and the parahippocampal gyrus in AD. These findings suggest that these two measurements are effective indices for understanding the neuropathology in AD. Studies using both gray matter volume and cortical thickness can separate the causes of the discrepancy, provide complementary information and carry out a comprehensive description of the morphological changes of brain structure.

  9. Modic changes, possible causes and relation to low back pain

    DEFF Research Database (Denmark)

    Albert, Hanne Birgit; Kjær, Per; Jensen, Tue Secher


    , and type 3 is sclerotic bone. The temporal evolution of MC is uncertain, but the time span is years. Subchondral bone marrow signal changes associated with pain can be observed in different specific infectious, degenerative and immunological diseases such as osseous infections, osteoarthritis, ankylosing...... spondylitis and spondylarthritis. In the vertebrae, MC is seen in relation to vertebral fractures, spondylodiscitis, disc herniation, severe disc degeneration, injections with chymopapain, and acute Schmorl's impressions. The aim of this paper is to propose two possible pathogenetic mechanisms causing Modic......-50% of patients with LBP and enable in the development of efficient treatments which might be antibiotics, special rehabilitation programmes, rest, stabilizing exercise, or surgical fixation, depending on the underlying cause for the MC....

  10. Attributing the causes of North Pacific oxygen change (United States)

    Deutsch, C.; Emerson, S.; Thompson, L.


    We investigate the variability of dissolved oxygen in the upper water column of the North Pacific using a hind cast model simulation. The model applies the biogeochemical framework of the Ocean Carbon Model Intercomparison Project (OCMIP) to an isopycnal General Circulation Model (GCM) whose circulation is forced at the surface by historical atmospheric conditions from 1948-2000. Simulated O2 changes from the 1980's to the 1990's include O2 decreases in the subpolar region, especially in the lower ventilated thermocline, and O2 increases over much of the subtropics. Both of these features are similar in pattern and magnitude to those observed along repeat transects through the subtropical and subpolar gyres [Emerson et al. 2004]. We perform a set of additional simulations designed to separate the contributions of changes in biology, ventilation, and circulation to O2 variability. We find that the direct effect of circulation variability, including a southward expansion of the subtropical gyre, is the dominant cause of O2 changes over much of the North Pacific. Variations in thermocline ventilation lead to significant O2 decreases in the Subarctic Northwest Pacific, and the impact of changes in biological export production are confined to the upper thermocline. Simulated O2 changes involve both long-term trends, such as the decreased Subarctic O2 due to reduced ventilation, as well as transient responses to short-term perturbations, many of which occurred in the 1970's.

  11. Do intravascular hypo- and hypervolaemia result in changes in central blood volumes?

    NARCIS (Netherlands)

    Vos, J. J.; Scheeren, T. W. L.; Loer, S. A.; Hoeft, A.; Wietasch, J. K. G.


    Background: Hypovolaemia is generally believed to induce centralization of blood volume. Therefore, we evaluated whether induced hypo-and hypervolaemia result in changes in central blood volumes (pulmonary blood volume (PBV), intrathoracic blood volume (ITBV)) and we explored the effects on the dist

  12. Medical errors; causes, consequences, emotional response and resulting behavioral change. (United States)

    Bari, Attia; Khan, Rehan Ahmed; Rathore, Ahsan Waheed


    To determine the causes of medical errors, the emotional and behavioral response of pediatric medicine residents to their medical errors and to determine their behavior change affecting their future training. One hundred thirty postgraduate residents were included in the study. Residents were asked to complete questionnaire about their errors and responses to their errors in three domains: emotional response, learning behavior and disclosure of the error. The names of the participants were kept confidential. Data was analyzed using SPSS version 20. A total of 130 residents were included. Majority 128(98.5%) of these described some form of error. Serious errors that occurred were 24(19%), 63(48%) minor, 24(19%) near misses,2(2%) never encountered an error and 17(12%) did not mention type of error but mentioned causes and consequences. Only 73(57%) residents disclosed medical errors to their senior physician but disclosure to patient's family was negligible 15(11%). Fatigue due to long duty hours 85(65%), inadequate experience 66(52%), inadequate supervision 58(48%) and complex case 58(45%) were common causes of medical errors. Negative emotions were common and were significantly associated with lack of knowledge (p=0.001), missing warning signs (p=<0.001), not seeking advice (p=0.003) and procedural complications (p=0.001). Medical errors had significant impact on resident's behavior; 119(93%) residents became more careful, increased advice seeking from seniors 109(86%) and 109(86%) started paying more attention to details. Intrinsic causes of errors were significantly associated with increased information seeking behavior and vigilance (p=0.003) and (p=0.01) respectively. Medical errors committed by residents have inadequate disclosure to senior physicians and result in negative emotions but there was positive change in their behavior, which resulted in improvement in their future training and patient care.

  13. Industrial arsenic contamination causes catastrophic changes in freshwater ecosystems. (United States)

    Chen, Guangjie; Shi, Haibin; Tao, Jianshuang; Chen, Li; Liu, Yuanyuan; Lei, Guoliang; Liu, Xiaohai; Smol, John P


    Heavy metal pollution is now widely recognized to pose severe health and environmental threats, yet much of what is known concerning its adverse impacts on ecosystem health is derived from short-term ecotoxicological studies. Due to the frequent absence of long-term monitoring data, little is known of the long-tem ecological consequences of pollutants such as arsenic. Here, our dated sediment records from two contaminated lakes in China faithfully document a 13.9 and 21.4-fold increase of total arsenic relative to pre-1950 background levels. Concurrently, coherent responses in keystone biota signal pronounced ecosystem changes, with a >10-fold loss in crustacean zooplankton (important herbivores in the food webs of these lake systems) and a >5-fold increase in a highly metal-tolerant alga. Such fundamental ecological changes will cascade through the ecosystem, causing potentially catastrophic consequences for ecosystem services in contaminated regions.

  14. Investigating causes of changes in runoff using hydrological simulation approach (United States)

    Wang, Guoqing; Zhang, Jianyun; Li, Xuemei; Bao, Zhenxin; Liu, Yanli; Liu, Cuishan; He, Ruimin; Luo, Junsong


    Stream flow plays a crucial role in environmental, social and economic contexts. It is of significance to investigate the causes of change in runoff for better water resources management. This study detects the variation trend of recorded runoff of the Gushan River, a tributary of the Yellow River located on the Loess Plateau with severe soil and water losing, and investigates the impacts of climate change and human activities on runoff using hydrological simulation approach. Results show that the recorded runoff at Gaoshiya station on the Gushan River has experienced a significant declining trend from 1954-2013 with an abrupt change occurring in 1973. SimHyd rainfall runoff model performs well for monthly discharge simulation with Nash-Sutcliffe coefficient of 82.6 % and relative error of 0.32 %. Runoff depth over the catchment in 1980-2013 reduced by 52.4 mm compared to the previous period, in which human activities and climate change contribute 61.5 and 38.5 % of the total runoff reduction, respectively. However, the human-induced impact tends to increase. Therefore, efforts to improve the ecology of the Loess Plateau should give sufficient attention to the impacts of human activity.

  15. Investigating causes of changes in runoff using hydrological simulation approach (United States)

    Wang, Guoqing; Zhang, Jianyun; Li, Xuemei; Bao, Zhenxin; Liu, Yanli; Liu, Cuishan; He, Ruimin; Luo, Junsong


    Stream flow plays a crucial role in environmental, social and economic contexts. It is of significance to investigate the causes of change in runoff for better water resources management. This study detects the variation trend of recorded runoff of the Gushan River, a tributary of the Yellow River located on the Loess Plateau with severe soil and water losing, and investigates the impacts of climate change and human activities on runoff using hydrological simulation approach. Results show that the recorded runoff at Gaoshiya station on the Gushan River has experienced a significant declining trend from 1954-2013 with an abrupt change occurring in 1973. SimHyd rainfall runoff model performs well for monthly discharge simulation with Nash-Sutcliffe coefficient of 82.6 % and relative error of 0.32 %. Runoff depth over the catchment in 1980-2013 reduced by 52.4 mm compared to the previous period, in which human activities and climate change contribute 61.5 and 38.5 % of the total runoff reduction, respectively. However, the human-induced impact tends to increase. Therefore, efforts to improve the ecology of the Loess Plateau should give sufficient attention to the impacts of human activity.

  16. Changes in the temperature-dependent specific volume of supported polystyrene films with film thickness (United States)

    Huang, Xinru; Roth, Connie B.


    Recent studies have measured or predicted thickness-dependent shifts in density or specific volume of polymer films as a possible means of understanding changes in the glass transition temperature Tg(h) with decreasing film thickness with some experimental works claiming unrealistically large (25%-30%) increases in film density with decreasing thickness. Here we use ellipsometry to measure the temperature-dependent index of refraction of polystyrene (PS) films supported on silicon and investigate the validity of the commonly used Lorentz-Lorenz equation for inferring changes in density or specific volume from very thin films. We find that the density (specific volume) of these supported PS films does not vary by more than ±0.4% of the bulk value for film thicknesses above 30 nm, and that the small variations we do observe are uncorrelated with any free volume explanation for the Tg(h) decrease exhibited by these films. We conclude that the derivation of the Lorentz-Lorenz equation becomes invalid for very thin films as the film thickness approaches ˜20 nm, and that reports of large density changes greater than ±1% of bulk for films thinner than this likely suffer from breakdown in the validity of this equation or in the difficulties associated with accurately measuring the index of refraction of such thin films. For larger film thicknesses, we do observed small variations in the effective specific volume of the films of 0.4 ± 0.2%, outside of our experimental error. These shifts occur simultaneously in both the liquid and glassy regimes uniformly together starting at film thicknesses less than ˜120 nm but appear to be uncorrelated with Tg(h) decreases; possible causes for these variations are discussed.

  17. Changes in Botrytis cinerea Conidia Caused by Berberis vulgaris Extract

    Directory of Open Access Journals (Sweden)

    Marcel PARVU


    Full Text Available Testing plant extracts for controlling fungal diseases is a main biocontrol method. More interesting is to see what happens to the fungus treated with the plant extract. Therefore, the aim of the study was to evaluate the antifungal activity of Berberis vulgaris extract on Botrytis cinerea and to examine the ultrastructural changes in B. cinerea conidia caused by the minimum inhibitory concentration (MIC, using SEM and TEM. The antifungal activity of B. vulgaris bark extract was investigated using agar dilution method, and compared to that of berberine. Fluconazole was used as the positive antimycotic control. It was found that (1 B. vulgaris bark extract had significant antifungal activity against B. cinerea, and its effect was stronger than that of pure berberine. It was also noted that (2B. vulgaris MIC caused severe structural changes of the conidia, comparable with berberine MIC effect; therefore (3 B. vulgaris bark extract might be recommended to be tested as a biocontrol agent against B. cinerea.

  18. Study on Volume Strain Inversion from Water Level Change of Well-aquifer Systems

    Institute of Scientific and Technical Information of China (English)

    Yan Rui; Gao Fuwang; Chen Yong


    Based on linear poroelastic and hydrogcology theory, a mathematical expression describing the relationship between water level change and aquifer volume strain is put forward. Combined with earth tidal theory, we analyze the response characteristics from well-aquifer water level change to earth tide of volume strain and present a method of volume strain inversion from water level change. Comparing the results of inversion with real observed data, we found that there is a good consistency. This suggcsts that the method of volume strain inversion from water level change is proper. It will offer a reference for learning about hydrogeology characteristics, volume strain and searching for precursor anomalies.

  19. Disruption of the endothelin A receptor in the nephron causes mild fluid volume expansion

    Directory of Open Access Journals (Sweden)

    Stuart Deborah


    Full Text Available Abstract Background Endothelin, via endothelin A receptors (ETA, exerts multiple pathologic effects that contribute to disease pathogenesis throughout the body. ETA antagonists ameliorate many experimental diseases and have been extensively utilized in clinical trials. The utility of ETA blockers has been greatly limited, however, by fluid retention, sometimes leading to heart failure or death. To begin to examine this issue, the effect of genetic disruption of ETA in the nephron on blood pressure and salt handling was determined. Methods Mice were generated with doxycycline-inducible nephron-specific ETA deletion using Pax8-rtTA and LC-1 transgenes on the background of homozygous loxP-flanked ETA alleles. Arterial pressure, Na metabolism and measures of body fluid volume status (hematocrit and impedance plethysmography were assessed. Results Absence of nephron ETA did not alter arterial pressure whether mice were ingesting a normal or high Na diet. Nephron ETA disruption did not detectably affect 24 hr Na excretion or urine volume regardless of Na intake. However, mice with nephron ETA knockout that were fed a high Na diet had mild fluid retention as evidenced by an increase in body weight and a fall in hematocrit. Conclusions Genetic deletion of nephron ETA causes very modest fluid retention that does not alter arterial pressure. Nephron ETA, under normal conditions, likely do not play a major role in regulation of Na excretion or systemic hemodynamics.

  20. Disproportional changes in hematocrit, plasma volume, and proteins during exercise and bed rest. (United States)

    Van Beaumont, W.; Greenleaf, J. E.; Juhos, L.


    The interrelationships between the changes in plasma volume, hematocrit, and plasma proteins during muscular exercise and bed rest were investigated. Proportionally, the changes in hematocrit are always smaller than the changes in plasma volume. For this reason changes in the concentration of blood constituents can only be quantitated on the basis of plasma volume changes. During short periods of intensive exercise, there was a small loss of plasma proteins. With prolonged submaximal exercise there was a net gain in plasma protein, which contributes to stabilization of the vascular volume. Prolonged bed rest induced hypoproteinemia; this loss of plasma protein probably plays an important role in recumbency hypovolemia.

  1. Factors influencing liver and spleen volume changes after donor hepatectomy for living donor liver transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Ji Hee; Ryeom, Hunku; Song, Jung Hup [Kyungpook National University Hospital, Daegu (Korea, Republic of)


    To define the changes in liver and spleen volumes in the early postoperative period after partial liver donation for living-donor liver transplantation (LDLT) and to determine factors that influence liver and spleen volume changes. 27 donors who underwent partial hepatectomy for LDLT were included in this study. The rates of liver and spleen volume change, measured with CT volumetry, were correlated with several factors. The analyzed factors included the indocyanine green (ICG) retention rate at 15 minutes after ICG administration, preoperative platelet count, preoperative liver and splenic volumes, resected liver volume, resected-to-whole liver volume ratio (LV{sub R}/LV{sub W}), resected liver volume to the sum of whole liver and spleen volume ratio [LV{sub R}/(LV{sub W} + SV{sub 0})], and pre and post hepatectomy portal venous pressures. In all hepatectomy donors, the volumes of the remnant liver and spleen were increased (increased rates, 59.5 ± 50.5%, 47.9 ± 22.6%). The increment rate of the remnant liver volume revealed a positive correlation with LV{sub R}/LV{sub W} (r = 0.759, p < 0.01). The other analyzed factors showed no correlation with changes in liver and spleen volumes. The spleen and remnant liver volumes were increased at CT volumetry performed 2 weeks after partial liver donation. Among the various analyzed factors, LV{sub R}/LV{sub W} influences the increment rate of the remnant liver volume.

  2. VMAT-Mediated changes in quantal size and vesicular volume

    NARCIS (Netherlands)

    Colliver, T L; Pyott, S J; Achalabun, M; Ewing, A G


    It has been well established that the volume of secretory vesicles can be modulated. However, we present the first data demonstrating that the amount of transmitter in a vesicle can regulate its volume. Amperometry and transmission electron microscopy have been used to determine that l-3,4-dihydroxy

  3. Variations of the earth's magnetic field and rapid climatic cooling: A possible link through changes in global ice volume (United States)

    Rampino, M. R.


    A possible relationship between large scale changes in global ice volume, variations in the earth's magnetic field, and short term climatic cooling is investigated through a study of the geomagnetic and climatic records of the past 300,000 years. The calculations suggest that redistribution of the Earth's water mass can cause rotational instabilities which lead to geomagnetic excursions; these magnetic variations in turn may lead to short-term coolings through upper atmosphere effects. Such double coincidences of magnetic excursions and sudden coolings at times of ice volume changes have occurred at 13,500, 30,000, 110,000, and 135,000 YBP.

  4. Dynamic volume changes in astrocytes are an intrinsic phenomenon mediated by bicarbonate ion flux.

    Directory of Open Access Journals (Sweden)

    Clare M Florence

    Full Text Available Astrocytes, the major type of non-neuronal cells in the brain, play an important functional role in extracellular potassium ([K(+](o and pH homeostasis. Pathological brain states that result in [K(+](o and pH dysregulation have been shown to cause astrocyte swelling. However, whether astrocyte volume changes occur under physiological conditions is not known. In this study we used two-photon imaging to visualize real-time astrocyte volume changes in the stratum radiatum of the hippocampus CA1 region. Astrocytes were observed to swell by 19.0±0.9% in response to a small physiological increase in the concentration of [K(+](o (3 mM. Astrocyte swelling was mediated by the influx of bicarbonate (HCO(3- ions as swelling was significantly decreased when the influx of HCO(3- was reduced. We found: 1 in HCO(3- free extracellular solution astrocytes swelled by 5.4±0.7%, 2 when the activity of the sodium-bicarbonate cotransporter (NBC was blocked the astrocytes swelled by 8.3±0.7%, and 3 in the presence of an extracellular carbonic anhydrase (CA inhibitor astrocytes swelled by 11.4±0.6%. Because a significant HCO(3- efflux is known to occur through the γ-amino-butyric acid (GABA channel, we performed a series of experiments to determine if astrocytes were capable of HCO(3- mediated volume shrinkage with GABA channel activation. Astrocytes were found to shrink -7.7±0.5% of control in response to the GABA(A channel agonist muscimol. Astrocyte shrinkage from GABA(A channel activation was significantly decreased to -5.0±0.6% of control in the presence of the membrane-permeant CA inhibitor acetazolamide (ACTZ. These dynamic astrocyte volume changes may represent a previously unappreciated yet fundamental mechanism by which astrocytes regulate physiological brain functioning.

  5. Self-organizing change? On drivers, causes and global environmental change (United States)

    von Elverfeldt, Kirsten; Embleton-Hamann, Christine; Slaymaker, Olav


    Within global environmental change research, certain external drivers generally are assumed to cause the environmental system to change. The most commonly considered drivers are relief, sea level, hydroclimate, and/or people. However, complexity theory and self-organizing systems provide a very different framework and means of explanation. Self-organization - understood as the aggregate processes internal to an environmental system that lead to a distinctive spatial, temporal, or other organization - reduces the possibility of implicating a specific process as being causal. The principle of equifinality, whereby two or more different drivers can generate the same form, has long been recognized within a process-response framework, as well as the concept of divergence, which states that similar causes or processes result in different effects. Both ideas differ from self-organization in that they (i) deal with drivers external to the system and (ii) imply concrete cause-and-effect relations that might be difficult to discern. The assumption is, however, that careful study will eventually lead to the true causes and processes. Studies of self-organization deal with the ways in which internal processes interact and may drive a system toward an instability threshold, the so-called bifurcation point. At this point, the system develops by chance and no single external or internal cause for the change can be defined. For research into environmental change this is a crucial theory for two reasons:

  6. Thrombus Volume Change Visualization after Endovascular Abdominal Aortic Aneurysm Repair (United States)

    Maiora, Josu; García, Guillermo; Macía, Iván; Legarreta, Jon Haitz; Boto, Fernando; Paloc, Céline; Graña, Manuel; Abuín, Javier Sanchez

    A surgical technique currently used in the treatment of Abdominal Aortic Aneurysms (AAA) is the Endovascular Aneurysm Repair (EVAR). This minimally invasive procedure involves inserting a prosthesis in the aortic vessel that excludes the aneurysm from the bloodstream. The stent, once in place acts as a false lumen for the blood current to travel down, and not into the surrounding aneurysm sac. This procedure, therefore, immediately takes the pressure off the aneurysm, which thromboses itself after some time. Nevertheless, in a long term perspective, different complications such as prosthesis displacement or bloodstream leaks into or from the aneurysmatic bulge (endoleaks) could appear causing a pressure elevation and, as a result, increasing the danger of rupture. The purpose of this work is to explore the application of image registration techniques to the visual detection of changes in the thrombus in order to assess the evolution of the aneurysm. Prior to registration, both the lumen and the thrombus are segmented


    Institute of Scientific and Technical Information of China (English)

    HE Pingsheng; ZHOU Zhiqiang; WANG Gengchao; PAN Caiyuan; WU Renjie


    The volume change of the copolymer epoxy resins can be controlled by copolymerizing epoxy resin E51 with 3,9-di (5-norbornene-2, 2)-1, 5, 7, 11-tetraoxaspiro [5, 5] undecane (NSOC). During curing,the volume changes of copolymer epoxy resins with various amounts of NSOC were measured with a dilatometer. Cure process does not produce volume change when epoxy resin E51: NSOC is 5.88: 1 in equivalent.

  8. Evaluating causes of population change in North American insectivorous songbirds (United States)

    Sauer, J.R.; Pendleton, G.W.; Peterjohn, B.G.


    Although the North American Breeding Bird Survey (BBS) is a principal source of information regarding populations of most North American bird species, many features of the survey complicate analysis of population change. Correlation studies based on BBS data cannot be used to unambiguously define cause and effect relationships. Recently, Bohning-Gaese et al. (1993) presented an analysis of population trends in insectivorous songbirds using data from the BBS. They concluded that predation has played an important role in influencing population trends. We review aspects of the analysis methods for estimating population trends (e.g., observer effects, data subset) and for associating mean trends with species attributes (e.g., confounding of attributes). Using alternative analyses of the same BBS data, we demonstrate that the evidence that predation is associated with population declines is weaker than they suggested. Based on our analyses the only factor among those tested that is consistently associated with population trends is migration status (i.e., short-distance migrant/resident vs. long-distance migrant) during the period 1978-1987. Also, we present evidence that the harsh winters of the mid-1970's severely depressed populations of short-distance migrant species, and may be responsible for the observed associations between migration status and population trends.

  9. Free Volume Changes in γ-Irradiated Polyethylene andPolytetraflourethylene

    Institute of Scientific and Technical Information of China (English)


    Positron lifetime spectrum was measured and the change of the free volume was studied for commercial polyethylene (PE) and polytetrafluoroethylene (PTFE) during γ-irradiation processingup to 265 kGy. The free volume size increases but the crystallinity decreases as irradiation doseincreases in PE. Both qualities (free volume size and crystallinity) in PTFE display an oppositebehavior. The fractional free volume reduces monotonically with increasing irradiation dose inboth PE and PTFE. The competition between the crosslinking and the splitting decompositionin polymers can be used to understand the free volume changes with irradiation dose.

  10. Quantitative prediction of respiratory tidal volume based on the external torso volume change: a potential volumetric surrogate

    Energy Technology Data Exchange (ETDEWEB)

    Li Guang; Arora, Naveen C; Xie Huchen; Ning, Holly; Citrin, Deborah; Kaushal, Aradhana; Zach, Leor; Camphausen, Kevin; Miller, Robert W [Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (United States); Lu Wei; Low, Daniel [Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110 (United States)], E-mail:


    An external respiratory surrogate that not only highly correlates with but also quantitatively predicts internal tidal volume should be useful in guiding four-dimensional computed tomography (4DCT), as well as 4D radiation therapy (4DRT). A volumetric surrogate should have advantages over external fiducial point(s) for monitoring respiration-induced motion of the torso, which deforms in synchronization with a patient-specific breathing pattern. This study establishes a linear relationship between the external torso volume change (TVC) and lung air volume change (AVC) by validating a proposed volume conservation hypothesis (TVC = AVC) throughout the respiratory cycle using 4DCT and spirometry. Fourteen patients' torso 4DCT images and corresponding spirometric tidal volumes were acquired to examine this hypothesis. The 4DCT images were acquired using dual surrogates in cine mode and amplitude-based binning in 12 respiratory stages, minimizing residual motion artifacts. Torso and lung volumes were calculated using threshold-based segmentation algorithms and volume changes were calculated relative to the full-exhalation stage. The TVC and AVC, as functions of respiratory stages, were compared, showing a high correlation (r = 0.992 {+-} 0.005, p < 0.0001) as well as a linear relationship (slope = 1.027 {+-} 0.061, R{sup 2} = 0.980) without phase shift. The AVC was also compared to the spirometric tidal volumes, showing a similar linearity (slope = 1.030 {+-} 0.092, R{sup 2} = 0.947). In contrast, the thoracic and abdominal heights measured from 4DCT showed relatively low correlation (0.28 {+-} 0.44 and 0.82 {+-} 0.30, respectively) and location-dependent phase shifts. This novel approach establishes the foundation for developing an external volumetric respiratory surrogate.

  11. A new microscopic method to analyse desiccation-induced volume changes in aeroterrestrial green algae. (United States)

    Lajos, K; Mayr, S; Buchner, O; Blaas, K; Holzinger, A


    Aeroterrestrial green algae are exposed to desiccation in their natural habitat, but their actual volume changes have not been investigated. Here, we measure the relative volume reduction (RVRED ) in Klebsormidium crenulatum and Zygnema sp. under different preset relative air humidities (RH). A new chamber allows monitoring RH during light microscopic observation of the desiccation process. The RHs were set in the range of ∼4 % to ∼95% in 10 steps. RVRED caused by the desiccation process was determined after full acclimation to the respective RHs. In K. crenulatum, RVRED (mean ± SE) was 46.4 ± 1.9%, in Zygnema sp. RVRED was only 34.3 ± 2.4% at the highest RH (∼95%) tested. This indicates a more pronounced water loss at higher RHs in K. crenulatum versus Zygnema sp. By contrast, at the lowest RH (∼4%) tested, RVRED ranged from 75.9 ± 2.7% in K. crenulatum to 83.9 ± 2.2% in Zygnema sp. The final volume reduction is therefore more drastic in Zygnema sp. These data contribute to our understanding of the desiccation process in streptophytic green algae, which are considered the closest ancestors of land plants.

  12. Simulating ecological changes caused by marine energy devices (United States)

    Schuchert, Pia; Elsaesser, Bjoern; Pritchard, Daniel; Kregting, Louise


    Marine renewable energy from wave and tidal technology has the potential to contribute significantly globally to energy security for future generations. However common to both tidal and wave energy extraction systems is concern regarding the potential environmental consequences of the deployment of the technology as environmental and ecological effects are so far poorly understood. Ecological surveys and studies to investigate the environmental impacts are time consuming and costly and are generally reactive; a more efficient approach is to develop 2 and 3D linked hydrodynamic-ecological modelling which has the potential to be proactive and to allow forecasting of the effects of array installation. The objective of the study was to explore tools which can help model and evaluate possible far- and near field changes in the environment and ecosystem caused by the introduction of arrays of marine energy devices. Using the commercial software, MIKE by DHI, we can predict and model possible changes in the ecosystem. MIKE21 and ECOLab modelling software provide the opportunity to couple high level hydrodynamic models with process based ecological models and/or agent based models (ABM). The flow solutions of the model were determined in an idealised tidal basin with the dimensions similar to that of Strangford Lough, Northern Ireland, a body of water renowned for the location of the first grid-connected tidal turbine, SeaGen. In the first instance a simple process oriented ecological NPZD model was developed which are used to model marine and freshwater systems describing four state variables, Nutrient, Phytoplankton, Zooplankton and Detritus. The ecological model was run and evaluated under two hydrodynamic scenarios of the idealised basin. This included no tidal turbines (control) and an array of 55 turbines, an extreme scenario. Whilst an array of turbines has an effect on the hydrodynamics of the Lough, it is unlikely to see an extreme effect on the NPZD model

  13. Implications of changing scattering properties on Greenland ice sheet volume change from Cryosat-2 altimetry

    DEFF Research Database (Denmark)

    Simonsen, Sebastian Bjerregaard; Sørensen, Louise Sandberg


    Long-term observations of surface elevation change of the Greenland ice sheet (GrIS) is of utmost importance when assessing the state of the ice sheet. Satellite radar altimetry offers a long time series of data over the GrIS, starting with ERS-1 in 1991. ESA's Cryosat-2 mission, launched in 2010...... waveform parameters to be applicable for correcting for changes in volume scattering. The best results in the Synthetic Aperture Radar Interferometric mode area of the GrIS are found when applying only the backscatter correction, whereas the best result in the Low Resolution Mode area is obtained by only...... applying a leading edge width correction. Using this approach to correct for the scattering properties, a volume loss of −292±38 km3 yr −1 is found for the GrIS for the time span November 2010 until November 2014. The inclusion of waveform parameter corrections and improved relocation for the GrIS, helps...

  14. Development of a finite element firn densification model for converting volume changes to mass changes

    CERN Document Server

    Cummings, Evan; Brinkerhoff, Douglas


    In regions where ice sheets are increasing in mass, there is a 50-200 m layer of old snow called firn which does not melt in the summer months. The density of firn tracks the transformation of snow into glacial ice at approximately 917 kg m^-3. The process of firn densification is important in at least two ways: 1) it can be a dominant component in the observed rate of change of the surface elevation, and 2) storage of liquid water in the lower density firn layer is now considered a critical component in the mass balance of ice sheets. If the rate of change of surface elevation can be equated with the rate of change in the mass of the ice sheet, we would have an excellent means of monitoring ice sheet mass balance. However, knowledge of firn densification rates is needed to make the inference of mass rate of change from volume rate of change. Several firn models have been created for areas without melt. We have reformulated these models with the finite-element software package FEniCS and integrated them with ...

  15. Epidural anesthesia, hypotension, and changes in intravascular volume

    DEFF Research Database (Denmark)

    Holte, Kathrine; Foss, Nicolai B; Svensén, Christer;


    BACKGROUND: The most common side effect of epidural or spinal anesthesia is hypotension with functional hypovolemia prompting fluid infusions or administration of vasopressors. Short-term studies (20 min) in patients undergoing lumbar epidural anesthesia suggest that plasma volume may increase wh...

  16. Change in heart rate variability following orthostasis relates to volume of exercise in healthy women. (United States)

    Gilder, Michael; Ramsbottom, Roger


    Physically active individuals demonstrate increased heart rate variability (HRV) during rest compared to sedentary individuals, but the impact of different volumes of regular exercise on the HRV response to postural change is not well understood. This study investigates change in HRV following orthostasis in seventy-two young women who exercise at low (LV) or high (HV) volumes of physical activity. Supine and standing R-R intervals were analysed by time domain, frequency domain and Poincaré plot methods. All methods revealed greater change in the vagal response in the HV group, indicating that HRV following postural change is modulated by volume of exercise.

  17. Orthostatic leg blood volume changes assessed by near-infrared spectroscopy

    DEFF Research Database (Denmark)

    Truijen, J; Kim, Y S; Krediet, C T P


    posture, volume accumulation in small blood vessels contributes significantly to the total fluid volume accumulated in the legs. Considering that near-infrared spectroscopy (NIRS) tracks postural blood volume changes within the small blood vessels of the lower leg, we evaluated the NIRS-determined changes...... separate days (n = 8). In response to HUT, an initially fast increase in [O(2)Hb] was followed by a gradual decline, while [HHb] increased continuously. The increase in [tHb] during HUT was closely related to the increase in total leg volume (r(2) = 0.95 ± 0.03). After tilt back, [O(2)Hb] declined below...

  18. Epidural anesthesia, hypotension, and changes in intravascular volume

    DEFF Research Database (Denmark)

    Holte, Kathrine; Foss, Nicolai B; Svensén, Christer


    hypotension is present, which may have implications for the choice of treatment of hypotension. However, no long-term information or measurements of plasma volumes with or without hypotension after epidural anesthesia are available. METHODS: In 12 healthy volunteers, the authors assessed plasma (125I...... and ephedrine has similar hemodynamic effects, the latter may be preferred in patients with cardiopulmonary diseases in which perioperative fluid overload is undesirable....

  19. Age-related changes in intracranial compartment volumes in normal adults assessed by magnetic resonance imaging. (United States)

    Matsumae, M; Kikinis, R; Mórocz, I A; Lorenzo, A V; Sándor, T; Albert, M S; Black, P M; Jolesz, F A


    Magnetic resonance (MR) image-based computerized segmentation was used to measure various intracranial compartments in 49 normal volunteers ranging in age from 24 to 80 years to determine age-related changes in brain, ventricular, and extraventricular cerebrospinal fluid (CSF) volumes. The total intracranial volume (sum of brain, ventricular, and extraventricular CSF) averaged 1469 +/- 102 cm3 in men and 1289 +/- 111 cm3 in women. The difference was attributable primarily to brain volume, which accounted for 88.6% of the respective intracranial volumes in both sexes, but was significantly larger in men (1302 +/- 112 cm3) than in women (1143 +/- 105 cm3). In both, the cranial CSF volume averaged 11.4%. Total intracranial volume did not change with age, although the normalized brain volume of both men and women began to decrease after the age of 40 years. This decrease was best reflected by expansion of the extraventricular CSF volume which, after the age of 50 years, was more marked in men than in women. The volume of the cranial CSF, as determined by MR image-based computerized segmentation, is considerably larger than traditionally accepted and resides mostly extraventricularly. Expansion of CSF volume with age provides a good index of brain shrinkage although evolving changes and growth of the head with age tend to confound the results.

  20. Changes in the planning target volume and liver volume dose based on the selected respiratory phase in respiratory-gated radiation therapy for a hepatocellular carcinoma (United States)

    Lee, Jae-Seung; Im, In-Chul; Kang, Su-Man; Goo, Eun-Hoe; Baek, Seong-Min


    The aim of this study was to quantitatively analyze the changes in the planning target volume (PTV) and liver volume dose based on the respiratory phase to identify the optimal respiratory phase for respiratory-gated radiation therapy for a hepatocellular carcinoma (HCC). Based on the standardized procedure for respiratory-gated radiation therapy, we performed a 4-dimensional computed tomography simulation for 0 ˜ 90%, 30 ˜ 70%, and 40 ˜ 60% respiratory phases to assess the respiratory stability (S R ) and the defined PTV i for each respiratory phase i. A treatment plan was established, and the changes in the PTV i and dose volume of the liver were quantitatively analyzed. Most patients (91.5%) passed the respiratory stability test (S R = 0.111 ± 0.015). With standardized respiration training exercises, we were able to minimize the overall systematic error caused by irregular respiration. Furthermore, a quantitative analysis to identify the optimal respiratory phase revealed that when a short respiratory phase (40 ˜ 60%) was used, the changes in the PTV were concentrated inside the center line; thus, we were able to obtain both a PTV margin accounting for respiration and a uniform radiation dose within the PTV.

  1. Accurate tracking of tumor volume change during radiotherapy by CT-CBCT registration with intensity correction (United States)

    Park, Seyoun; Robinson, Adam; Quon, Harry; Kiess, Ana P.; Shen, Colette; Wong, John; Plishker, William; Shekhar, Raj; Lee, Junghoon


    In this paper, we propose a CT-CBCT registration method to accurately predict the tumor volume change based on daily cone-beam CTs (CBCTs) during radiotherapy. CBCT is commonly used to reduce patient setup error during radiotherapy, but its poor image quality impedes accurate monitoring of anatomical changes. Although physician's contours drawn on the planning CT can be automatically propagated to daily CBCTs by deformable image registration (DIR), artifacts in CBCT often cause undesirable errors. To improve the accuracy of the registration-based segmentation, we developed a DIR method that iteratively corrects CBCT intensities by local histogram matching. Three popular DIR algorithms (B-spline, demons, and optical flow) with the intensity correction were implemented on a graphics processing unit for efficient computation. We evaluated their performances on six head and neck (HN) cancer cases. For each case, four trained scientists manually contoured the nodal gross tumor volume (GTV) on the planning CT and every other fraction CBCTs to which the propagated GTV contours by DIR were compared. The performance was also compared with commercial image registration software based on conventional mutual information (MI), VelocityAI (Varian Medical Systems Inc.). The volume differences (mean±std in cc) between the average of the manual segmentations and automatic segmentations are 3.70+/-2.30 (B-spline), 1.25+/-1.78 (demons), 0.93+/-1.14 (optical flow), and 4.39+/-3.86 (VelocityAI). The proposed method significantly reduced the estimation error by 9% (B-spline), 38% (demons), and 51% (optical flow) over the results using VelocityAI. Although demonstrated only on HN nodal GTVs, the results imply that the proposed method can produce improved segmentation of other critical structures over conventional methods.

  2. Nasal Drug Absorption from Powder Formulations: Effect of Fluid Volume Changes on the Mucosal Surface. (United States)

    Tanaka, Akiko; Furubayashi, Tomoyuki; Enomura, Yuki; Hori, Tomoki; Shimomura, Rina; Maeda, Chiaki; Kimura, Shunsuke; Inoue, Daisuke; Kusamori, Kosuke; Katsumi, Hidemasa; Sakane, Toshiyasu; Yamamoto, Akira


    The effect of changes in the mucosal fluid volume on the nasal drug absorption of powder formulations was evaluated using warfarin (WF), piroxicam (PXC), and norfloxacin (NFX) as model drugs. Lactose and sodium chloride (NaCl), which are water soluble and small-sized chemicals that increase osmotic pressure after dissolution, were used as excipients to change the mucosal fluid volume. The in vitro study using a Madin-Darby canine kidney (MDCK) cell monolayer indicated that lactose and NaCl, sprayed over the surface of air interface monolayers, increased the fluid volume on the monolayer surface and enhanced the transepithelial transport of the model drugs. The in vivo animal study indicated that the nasal absorption of PXC is enhanced by lactose and NaCl after nasal administration of the powder formulations. This is likely due to the enhanced dissolution of PXC on fluid-rich nasal mucosa and an increase in the effective surface area for drug permeation, which lead to better nasal absorption. However, both excipients failed to increase the nasal absorption of WF and NFX. To clarify the mechanism of the drug-dependent effect of lactose and NaCl, the nasal residence of the formulation was examined using FD70 as a non-absorbable marker. The nasal clearance of FD70 was enhanced by lactose and NaCl, leading to a decrease in the nasal drug absorption. Lactose and NaCl caused no damage to the nasal tissue. These results indicate that the addition of water-soluble excipients such as lactose to powder formulations can enhance the nasal absorption of highly permeable but poorly soluble drugs.

  3. Human choice and climate change. Volume 2: Resources and technology

    Energy Technology Data Exchange (ETDEWEB)

    Rayner, S.; Malone, E.L.


    Foreward: Preface; Introduction; The natural science of global climate change; Land and water use; Coastal zones and oceans; Energy and industry; Energy and social systems; Technological change; and Sponsoring organizations, International Advisory Board, and project participants.

  4. Neuronal changes caused by Trypanosoma cruzi: an experimental model

    Directory of Open Access Journals (Sweden)

    Neide M Moreira


    Full Text Available Define an experimental model by evaluating quantitative and morphometric changes in myenteric neurons of the colon of mice infected with Trypanosoma cruzi. Twenty-eight Swiss male mice were distributed into groups: control (CG, n=9 and inoculated with 100 (IG100, n=9 and 1000 (IG1000, n=10 blood trypomastigotes, Y strain-T. cruzi II. Parasitemia was evaluated from 3-25 days post inoculation (dpi with parasites peak of 7.7 × 10(6 and 8.4 × 10(6 trypomastigotes/mL at 8th dpi (p>0.05 in IG100 and IG1000, respectively. Chronic phase of the infection was obtained with two doses of 100mg/Kg/weight and one dose of 250mg/Kg/weight of Benznidazole on 11, 16 and 18 dpi. Three animals from each group were euthanized at 18, 30 and 75 dpi. The colon was stained with Giemsa. The quantitative and morphometric analysis of neurons revealed that the infection caused a decrease of neuronal density on 30th dpi (pDefinir um modelo experimental de avaliação de alterações quantitativas e morfométricas nos neurônios mientéricos do cólon de camundongos infectados pelo Trypanosoma cruzi. Vinte e oito camundongos Swiss machos foram distribuídos nos grupos: controle (GC, n=9 e infectados com 100 (IG100, n=9 e 1000 (IG1000, n=10 tripomastigotas sanguíneos, cepa Y-T. cruzi II. A parasitemia foi avaliada 3-25 dias pós inoculação (dpi, com pico de parasitos de 7,7 × 10(6 e 8,4 × 10(6 tripomastigotas/mL no 8º dpi (p>0,05 em IG100 e IG1000, respectivamente. A fase crônica da infecção foi obtida com duas doses de 100mg/Kg/weight e uma dose de 250mg/Kg/ weight do benznidazol, em 11, 16 e 18 dpi. Três animais de cada grupo foram sacrificados aos 18, 30 e 75 dpi. O cólon foi corado com Giemsa. A análise quantitativa e morfométrica de neurônios revelou que a infecção causou uma diminuição da densidade neuronal no 30º dpi (p<0,05 e 75 dpi (p<0,05 em IG100 e IG1000. A infecção causou morte e hipertrofia neuronal no 75º dpi em IG100 e IG1000 (p<0,05, p

  5. Changes in blood volume and response to vaso-active drugs in horizontally casted primates (United States)

    Dickey, D. T.; Teoh, K. K.; Sandler, H.; Stone, H. L.


    Experiments were performed on horizontally casted primates (male rhesus monkeys) in order to note changes in blood volume caused by horizontal restraint, to compare orthostatic tolerance before and after casting using the responses to upright tilting, to begin to uncover the cardiovascular and neural mechanisms involved in deconditioning, and to compare the data with that obtained from bed-rested human subjects and from humans exposed to weightlessness. Bolus injections of norepinephrine of 2.0 microgram/kg, phenylephrine of 4.0 microgram/kg, and nitroprusside of 2.0 microgram/kg were administered; and aortic pressure and heart rate were recorded during the injections. The results indicate that the horizontally casted primate is a valid animal model for studying the effects of simulated zero-G on the human cardiovascular system.

  6. Trait positive affect is associated with hippocampal volume and change in caudate volume across adolescence. (United States)

    Dennison, Meg; Whittle, Sarah; Yücel, Murat; Byrne, Michelle L; Schwartz, Orli; Simmons, Julian G; Allen, Nicholas B


    Trait positive affect (PA) in childhood confers both risk and resilience to psychological and behavioral difficulties in adolescence, although explanations for this association are lacking. Neurodevelopment in key areas associated with positive affect is ongoing throughout adolescence, and is likely to be related to the increased incidence of disorders of positive affect during this period of development. The aim of this study was to prospectively explore the relationship between trait indices of PA and brain development in subcortical reward regions during early to mid-adolescence in a community sample of adolescents. A total of 89 (46 male, 43 female) adolescents participated in magnetic resonance imaging assessments during both early and mid-adolescence (mean age at baseline = 12.6 years, SD = 0.45; mean follow-up period = 3.78 years, SD = 0.21) and also completed self-report measures of trait positive and negative affect (at baseline). To examine the specificity of these effects, the relation between negative affect and brain development was also examined. The degree of volume reduction in the right caudate over time was predicted by PA. Independent of time, larger hippocampal volumes were associated with higher PA, and negative affect was associated with smaller left amygdala volume. The moderating effect of negative affect on the development of the left caudate varied as a function of lifetime psychiatric history. These findings suggest that early to mid-adolescence is an important period whereby neurodevelopmental processes may underlie key phenotypes conferring both risk and resilience for emotional and behavioral difficulties later in life.

  7. Can climate change cause groundwater scarcity? An estimate for Bihar

    National Research Council Canada - National Science Library

    Sharma, Bhawna; Jangle, Nihar; Bhatt, Nidhi; Dror, David M


    .... We examine the exposure of this resource to stress due to climate change; specifically, we estimate the influence of climate parameters on availability of groundwater in Bihar in about 10 years (2021) and 40 years (2051...

  8. Cellular Automaton Simulation For Volume Changes Of Solidifying Nodular Cast Iron

    Directory of Open Access Journals (Sweden)

    Burbelko A.


    Full Text Available Volume changes of the binary Fe-C alloy with nodular graphite were forecast by means of the Cellular Automaton Finite Differences (CA-FD model of solidification. Simulations were performed in 2D space for differing carbon content. Dependences of phase density on temperature were considered in the computations; additionally density of the liquid phase and austenite were deemed as a function of carbon concentration. Changes of the specific volume were forecast on the base of the phase volume fractions and changes of phase density. Density of modeled material was calculated as weighted average of densities of each phase.

  9. How do sock ply changes affect residual-limb fluid volume in people with transtibial amputation?

    Directory of Open Access Journals (Sweden)

    Joan E. Sanders, PhD


    Full Text Available The purpose of this research was to investigate the influence of sock addition and removal on residual-limb fluid volume in people using prosthetic limbs. We used bioimpedance analysis to measure residual-limb extracellular fluid volume on 28 transtibial amputee subjects during 30 min test sessions. Upon addition of a one-ply polyester sock, residual-limb fluid volume changes ranged from −4.0% to 0.8% (mean −0.9 +/− 1.3% of the initial limb fluid volume. Changes for sock removal ranged from −1.2% to 2.8% (mean 0.5 +/− 0.8%. Subjects who reduced in fluid volume with both addition and removal of a sock and subjects with high positive ratios between the fluid-volume loss upon sock addition and gain upon sock removal (high add/remove [AR] ratios tended to have arterial disease, were obese, and were smokers. Subjects with low positive AR ratios, subjects who increased in fluid volume both with sock addition and removal, and a single subject who increased in fluid volume with sock addition and decreased with sock removal tended to be nonsmokers and either individuals in good health without complications or individuals without arterial problems. Results are relevant for the anticipation of limb volume changes during prosthetic fitting and toward the design of adjustable-socket technologies.

  10. Changes of the landscape caused by industrial smoke acids

    Energy Technology Data Exchange (ETDEWEB)

    Bohne, H.


    The influence of industrial smoke emissions of sulfur dioxide, fluorine and chlorine on landscape is examined. Sulfur dioxide emission has been estimated to cause 80% of the plant damage found near industrial surroundings according to the literature, but more recent evidence has pointed to fluorine-containing exhaust as being the main culprit of smoke damage. Two examples are presented in favor of the litter hypothesis. Fluorine-containing exhausts have been found to cause damage in gladiolas, horse-chestnuts, damson plums, apricots, forest plants; leaf burning and permanent damage have been common. Plant damage has also been observed in the vicinity of chlorine-emitting facilities. Growth depression, bleached or lightened leaves, and necroses have been observed. Damage to pear leaves from chlorine appeared as ill defined, brown necrosis in contrast to the sharply defined black-brown edges resulting from fluorine damage.

  11. Changes in down dead wood volume across a chronosequence of silvicultural openings in southern Indiana forests (United States)

    Michael A. Jenkins; George R. Parker


    The volume and decay stages of down dead wood were evaluated across a chronosequence of 46 silvicultural openings and 10 uncut control stands to determine how down dead wood volume changes with stand development. Openings ranged in age from 8 to 26 years and were divided into three age groups: (1) 16 years. Individual logs...

  12. Study of the seroma volume changes in the patients who underwent Accelerated Partial Breast Irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dae Ho; Son, Sang Jun; Mun, Jun Ki; Seo, Seok Jin; Lee, Je Hee [Dept. of Radiation Oncology, Seoul National University Hospital, Seoul (Korea, Republic of)


    By analyzing seroma volume changes in the patients who underwent Partial breast radiation therapy after breast conserving surgery, we try to contribute to the improvement of radiotherapy effect. Enrolled 20 patients who underwent partial breast radiation therapy by ViewRay MRIdian System were subject. After seeking for the size of the removed sample in the patients during surgery and obtained seroma volume changes on a weekly basis. On the Basis of acquired volume, it was compared with age, term from start of the first treatment after surgery, BMI (body mass index) and the extracted sample size during surgery. And using the ViewRay MRIdian RTP System, the figure was analyzed by PTV(=seroma volume + margin) to obtain a specific volume of the Partial breast radiation therapy. The changes of seroma volume from MR simulation to the first treatment (a week) is 0~5% in 8, 5~10% in 3, 10 to 15% in 2, and 20% or more in 5 people. Two patients(A, B patient) among subjects showed the biggest change. The A patient's 100% of the prescribed dose volume is 213.08 cc, PTV is 181.93 cc, seroma volume is 15.3 cc in initial plan. However, while seroma volume decreased 65.36% to 5.3 cc, 100% of the prescribed dose volume was reduced to 3.4% to 102.43 cc and PTV also did 43.6% to 102.54 cc. In the case of the B patient, seroma volume decreased 42.57% from 20.2 cc to 11.6 cc. Because of that, 100% of the prescribed dose volume decreased 8.1% and PTV also did to 40%. As the period between the first therapy and surgery is shorter, the patient is elder and the size of sample is smaller than 100 cc, the change grow bigger. It is desirable to establish an adaptive plan according to each patient's changes of seroma volume through continuous observation. Because partial breast patients is more sensitive than WBRT patients about dose conformity in accordance with the volume change.

  13. Brain death causes structural and inflammatory changes in donor intestine

    NARCIS (Netherlands)

    Koudstaal, L.G.; 't Hart, Marieke; van den Berg, Anke; Olinga, Peter; van Goor, Harry; Ploeg, R.J; Leuvenink, H.G.


    Brain death donors are frequently used for transplantation. Previous studies showed that brain death (BD) negatively affects the immunological and inflammatory status of both liver and kidney. Objective. Therefore we studied the inflammatory and morphological changes in donor small intestine after

  14. Frequency of Iatrogenic Changes Caused from Overhang Restorations

    Directory of Open Access Journals (Sweden)

    Boteva E.


    Full Text Available Overhangs from different restorations are an iatrogenic error with different results, short and long term consequences related to bone changes and periodontal diseases. Amalgam “tattoos”, idiopathic subgingival hypertrophy, marginal periodontitis and bone reductions in the intradental septum are major problems. The aim of the present study is to evaluate the frequency of traumatic restorations in distal teeth and clinical criteria, related to the x-ray findings. Evaluating criteria, for repairing the overhangs or for replacement of the restorations, is also a goal. Three hundred and sixteen - 316 patients from both sexes, 632 dental x-rays with 948 distal teeth and 632 restorations, at least two radiographs for each patient, were analyzed. Overhangs are classified in three groups: small, middle and large. In the criteria bone changes from the overhangs are analyzed separately from the existing or nonexisting bone changes from a generalized periodontal diseases. The frequency of iatrogenic changes in this cohort group is 10.6% from 632 restored teeth. This is a relatively small number compared with the other published studies. These overhangs are on distal teeth in sound teeth arches which makes them difficult for corrections. The evaluated criteria for replacement based on x-ray findings and clinical experience includes: operative and nonoperative corrections, restoration replacement, perio- and endo-therapy and follow up terms for secondary caries.

  15. Volume changes of extremely large and giant intracranial aneurysms after treatment with flow diverter stents

    Energy Technology Data Exchange (ETDEWEB)

    Carneiro, Angelo; Byrne, James V. [ohn Radcliffe Hospital, Oxford Neurovascular and Neuroradiology Research Unit, Nuffield Department of Surgical Sciences, Oxford (United Kingdom); Rane, Neil; Kueker, Wilhelm; Cellerini, Martino; Corkill, Rufus [John Radcliffe Hospital, Department of Neuroradiology, Oxford (United Kingdom)


    This study assessed volume changes of unruptured large and giant aneurysms (greatest diameter >20 mm) after treatment with flow diverter (FD) stents. Clinical audit of the cases treated in a single institution, over a 5-year period. Demographic and clinical data were retrospectively collected from the hospital records. Aneurysm volumes were measured by manual outlining at sequential slices using computerised tomography (CT) or magnetic resonance (MR) angiography data. The audit included eight patients (seven females) with eight aneurysms. Four aneurysms involved the cavernous segment of the internal carotid artery (ICA), three the supraclinoid ICA and one the basilar artery. Seven patients presented with signs and symptoms of mass effect and one with seizures. All but one aneurysm was treated with a single FD stent; six aneurysms were also coiled (either before or simultaneously with FD placement). Minimum follow-up time was 6 months (mean 20 months). At follow-up, three aneurysms decreased in size, three were unchanged and two increased. Both aneurysms that increased in size showed persistent endosaccular flow at follow-up MR; in one case, failure was attributed to suboptimal position of the stent; in the other case, it was attributed to persistence of a side branch originating from the aneurysm (similar to the endoleak phenomenon of aortic aneurysms). At follow-up, five aneurysms were completely occluded; none of these increased in volume. Complete occlusion of the aneurysms leads, in most cases, to its shrinkage. In cases of late aneurysm growth or regrowth, consideration should be given to possible endoleak as the cause. (orig.)


    Energy Technology Data Exchange (ETDEWEB)

    Shen, S; DeNardo, G L; Yuan, A; Siantar, C H; O' Donnell, R T; DeNardo, S J


    Splenomegaly is frequently found in non-Hodgkin's lymphoma (NHL) patients. This study evaluated the implications of splenic volume change in response to radioimmunotherapy (RIT). Twenty-nine NHL patients treated with radiolabeled-Lym-1 and 9 breast cancer patients (reference group) treated with radiolabeled-ChL6, BrE-3 or m170 were analyzed using CT splenic images obtained before and after RIT. Patient-specific radiation doses to spleen were determined using actual splenic volume determined by CT and body weight. In 13 of 29 NHL patients who had splenic volume {le} 310 ml, there was no or small change (-23 to 15 mL) in splenic volume, despite splenic doses as high as 14.4 Gy. Similarly, in a reference group of 9 breast cancer patients, there was no or small change (-5 to 13 mL), despite splenic doses as high as 11.4 Gy. In contrast, 13 of 29 NHL patients who had splenic volume 380-1400 mL, splenic volume decreased by 68 to 548 mL despite splenic doses as low as 1.40 Gy. Ten of 29 NHL patients with greater than a 15% decrease in splenic volume after RIT had nodal tumor regression (5 CR, 5 PR). In the remaining 19 NHL patients with less than a 15% decrease in splenic volume after RIT, there were 7 non-responders (5 CR and 7 PR). Splenic volume changes were found in NHL patients with splenomegaly. These splenic volume changes is likely due to therapeutic effect on malignant lymphocytes associated with splenomegaly. Nodal tumor response was more likely when splenomegaly decreased after RIT.

  17. Atmospheric oxygenation caused by a change in volcanic degassing pressure. (United States)

    Gaillard, Fabrice; Scaillet, Bruno; Arndt, Nicholas T


    The Precambrian history of our planet is marked by two major events: a pulse of continental crust formation at the end of the Archaean eon and a weak oxygenation of the atmosphere (the Great Oxidation Event) that followed, at 2.45 billion years ago. This oxygenation has been linked to the emergence of oxygenic cyanobacteria and to changes in the compositions of volcanic gases, but not to the composition of erupting lavas--geochemical constraints indicate that the oxidation state of basalts and their mantle sources has remained constant since 3.5 billion years ago. Here we propose that a decrease in the average pressure of volcanic degassing changed the oxidation state of sulphur in volcanic gases, initiating the modern biogeochemical sulphur cycle and triggering atmospheric oxygenation. Using thermodynamic calculations simulating gas-melt equilibria in erupting magmas, we suggest that mostly submarine Archaean volcanoes produced gases with SO(2)/H(2)S atmosphere.

  18. Yield stress, volume change, and shear strength behaviour of unsaturated soils: validation of the SFG model

    National Research Council Canada - National Science Library

    Zhou, Annan; Sheng, Daichao


    The model recently presented by Sheng, Fredlund, and Gens, known as the SFG model, provides a consistent explanation of yield stress, shear strength, and volume change behaviour of unsaturated soils...

  19. [Bone and joint changes caused by exposure to local vibration]. (United States)

    Kir'iakov, V A; Sukhova, A V; Saarkoppel', L M


    The question to include locomotory disorders into set of symptoms of vibration disease due to local vibration is discussed over years. Studies of clinical symptoms of vibration disease in machinery construction workers demonstrated that bone and joint changes risk depends on intensity of vibration factor and length of exposure to local vibration, as well as on work hardiness. The authors specified X-ray criteria of bone and joint disorders and laboratory markers of bone tissue injury under exposure to local vibration.

  20. Sertindole causes distinct electrocardiographic T-wave morphology changes

    DEFF Research Database (Denmark)

    Nielsen, Jimmi; Graff, Claus; Hardahl, Thomas Bork;


    Sertindole's propensity to prolong the QT interval relates to blockade of the KCNH2 (HERG) encoded Ikr potassium channel, but there has been limited detailed data on T-wave morphology changes. Digital 12-lead ECG was recorded at baseline and at steady-state in 37 patients switched to sertindole....... ECG was analyzed for quantitative T-wave morphology changes and Fridericia-corrected QT duration (QTcF). Prominent T-wave morphology changes occurred during sertindole treatment and in some cases without concomitant prolongation of the QTcF interval. Four patients developed notched T-waves during...... sertindole treatment. Mean QTc prolongation was 19 ms. The mean effect size was higher for T-wave morphology combination score (MCS) (ES=1.92; 95% CI: 1.35-2.49) compared to the mean effect size for QTcF (ES=0.88; 95% CI: 0.52-1.24). The use of T-wave morphology analysis may become clinically relevant...

  1. Cryopreservation Causes Genetic and Epigenetic Changes in Zebrafish Genital Ridges.

    Directory of Open Access Journals (Sweden)

    Marta F Riesco

    Full Text Available Cryopreservation is an important tool routinely employed in Assisted Reproduction Technologies (ARTs and germplasm banking. For several years, the assessment of global DNA fragmentation seemed to be enough to ensure the integrity of genetic material. However, cryopreservation can produce molecular alterations in key genes and transcripts undetectable by traditional assays, such modifications could interfere with normal embryo development. We used zebrafish as a model to study the effect of cryopreservation on key transcripts and genes. We employed an optimized cryopreservation protocol for genital ridges (GRs containing primordial germ cells (PGCs considered one of the best cell sources for gene banking. Our results indicated that cryopreservation produced a decrease in most of the zebrafish studied transcripts (cxcr4b, pou5f1, vasa and sox2 and upregulation of heat shock proteins (hsp70, hsp90. The observed downregulation could not always be explained by promoter hypermethylation (only the vasa promoter underwent clear hypermethylation. To corroborate this, we used human spermatozoa (transcriptionally inactive cells obtaining a reduction in some transcripts (eIF2S1, and LHCGR. Our results also demonstrated that this effect was caused by freezing/thawing rather than exposure to cryoprotectants (CPAs. Finally, we employed real-time PCR (qPCR technology to quantify the number of lesions produced by cryopreservation in the studied zebrafish genes, observing very different vulnerability to damage among them. All these data suggest that molecular alterations caused by cryopreservation should be studied in detail in order to ensure the total safety of the technique.

  2. Causes of change in 20th century global river discharge (United States)

    Gerten, Dieter; Rost, Stefanie; von Bloh, Werner; Lucht, Wolfgang


    A global vegetation and hydrology model (LPJmL) was applied to quantify the contributions of changing precipitation, temperature, atmospheric CO2 content, land use and irrigation to worldwide trends in 20th century river discharge (Q). Consistently with observations, Q decreased in parts of Africa, central/southern Asia and south-eastern Europe, and increased especially in parts of North America and western Asia. Based on the CRU TS2.1 climatology, total global Q rose over 1901-2002 (trend, 30.8 km3 a-2, equaling 7.7%), due primarily to increasing precipitation (individual effect, +24.7 km3 a-2). Global warming (-3.1), rising CO2 (+4.4), land cover changes (+5.9) and irrigation (-1.1) also had discernible effects. However, sign and magnitude of trends exhibited pronounced decadal variability and differed among precipitation forcing datasets. Since recent trends in these and other drivers of Q are mainly anthropogenic, we conclude that humans exert an increasing influence on the global water cycle.

  3. Changes in tropical Late Carboniferous compression floras and their causes

    Energy Technology Data Exchange (ETDEWEB)

    Pfefferkorn, H.W. (Univ. of Pennsylvania, Philadelphia, PA (United States). Dept. of Geology)


    In the Late Carboniferous ten biostratigraphic boundaries can be recognized based on compression floras. Some of these boundaries coincide with classical stage boundaries whereas others do not. These boundaries are observable throughout Eurameria. In most cases the same species are involved in North America and Europe. Four boundaries are characterized by extinction events that involve only a few or many taxa. Four boundaries are characterized by origination of single taxa or by changes in the dominance of taxonomic groups. Two boundaries near the base of the Late Carboniferous seem to coincide with different stages in the onset of the ice age on Gondwanaland. However, it has not been clearly demonstrated what the local climatic signals in the tropics were. Three boundaries in the late Late Carboniferous are connected with well established trends toward dryer climate. It appears that many of these floral changes were climatically controlled. The actual triggering condition seems to have been produced by a variable combination of short term (allocyclic) and long term (orogeny, continental movement) effects. In one case the reason for the extinction is not obvious and could be biotic in nature.

  4. Changes in a coflowing jet structure caused by acoustic forcing

    Energy Technology Data Exchange (ETDEWEB)

    Cerecedo, Luis M.; Aisa, Luis; Garcia, Juan A.; Santolaya, Jose L. [Fluid Mechanics Department, University of Zaragoza, Zaragoza (Spain)


    In the present work, the changes in the basic turbulence field of an axisymmetric jet in a coflow when acoustic forcing is applied are investigated. The main objective is to discriminate between changes produced by the acoustic forcing and those produced by the presence of solid particles in a two-phase flow. Power spectra of the axial velocities, u(t), are analyzed to reinforce the idea of the existence of a natural frequency. Time-averaged data are used to characterize the basic flow. This basic flow is compared with the flow altered by the acoustic forcing. By smoothing the phase-averaged rms data (mean statistical curve), the general behavior of the instantaneous fluctuations are unveiled and compared with that of the natural (unforced) jet. In this way, it can be seen that rms values in the forced cases are higher than in the unforced ones, due to the contribution of the external forcing. However, once the coherent structures are extinguished, both forced and unforced jets show a similar trend. (orig.)

  5. Depression may be associated with hippocampal volume changes ...

    African Journals Online (AJOL)


    ment score equal to 1.7 Psychosocial functioning is now regarded as a important ... adequate treatment to full remission carries considerable risks not only for the ... It may also lead to or exacerbate structural brain changes in depression, most particu- .... toxicity and decreased levels of BDNF with neuronal atrophy in the.

  6. Changing weather causes behavioral responses in the lower mesopelagic

    KAUST Repository

    Kaartvedt, S


    Mesopelagic acoustic scattering layers at a 700 m deep location in the Red Sea ascended 70 to 80 m during a passing rain storm that reduced light levels at the surface by more than 2 orders of magnitude. The changes in vertical distribution were observed down to the deepest part of the water column and were interpreted as a response to sudden dark weather. However, light measurements suggest that the mesopelagic targets (fish) did not fully compensate for the reduction in ambient light, and the calculated light levels in the scattering layers were similar to 1 order of magnitude lower during the passage of the storm. The results show that fluctuating weather conditions may affect pelagic ecosystems even towards the lower parts of the mesopelagic zone.

  7. Is climate change causing increased rockfall frequency in Austria?

    Directory of Open Access Journals (Sweden)

    O. Sass


    Full Text Available Potentially, increasing rockfall hazards triggered by climate change are a major concern expressed both in scientific and non-scientific media. An existing rockfall inventory for Austria including 252 events from ca. 1900 to 2010, mainly from non-permafrost areas, was analysed. The correlation of events with temperatures is very weak and no increase of rockfall frequency during warmer periods was observed. The peak of rockfall activity is in spring, whereas in recent decades a secondary summer maximum appeared in the records. A possible reason for this shift is reduced rockfall activity in spring due to warmer winters. We conclude that a premature warning of increasing rockfall hazard, especially below the permafrost limit, is not supported by the existing data.

  8. Bone changes caused by experimental Solanum malacoxylon poisoning in rabbits

    Directory of Open Access Journals (Sweden)

    José Ignacio Aguirre


    Full Text Available The aim of this study was to describe the bone changes observed after a daily oral administration of the calcinogenic plant Solanum malacoxylon (syn. S. glaucophyllum (Sm during 9 days. The Sm-poisoned rabbits had an increase of bone resorption in the endosteal surface of the cortical zone and also in the surface covered by osteoblasts of the primary and secondary spongiosa of the trabecular bone compartment. Moreover, the epiphyseal growth plates in long bones appeared narrower than in the control rabbits, with reduction of the proliferative and hyperthrophic chondrocyte zones. The electron microscopic study revealed a significant decrease of proteoglycans in the hyperthrophic chondrocyte zone evidenced by a significant reduction of rutenium red positive granules in the poisoned rabbit. Altogether, these data suggest that cell differentiation may play a pivotal role in the pathogenesis of Sm-induced bone lesions.

  9. The Major Causes of Cost Growth in Defense Acquisition, Volume II: Main Body (United States)


    Acquisition Volume II: Main Body Gene Porter, Project Leader Brian Gladstone C. Vance Gordon Nicholas Karvonides R. Royce Kneece, Jr. Jay Mandelbaum...Main Body Gene Porter, Project Leader Brian Gladstone C. Vance Gordon Nicholas Karvonides R. Royce Kneece, Jr. Jay Mandelbaum William D. O’Neil iii...information to DoD management on the status of the most important acquisition programs. Since 1969 , Congress has required that the SARs for MDAPs be

  10. Is breast asymmetry caused by volume differences in women with pectus excavatum? (United States)

    Rha, Eun Young; Kim, Ji-Min; Yoo, Gyeol; Jeong, Jin Yong; Hwang, Duck Ki; Kim, Ki Jun


    This study determined the breast volumes of female patients with pectus excavatum that led to asymmetry and hypoplasia compared with normal women. This retrospective study enrolled 13 patients diagnosed with pectus excavatum and 13 normal women, randomly selected from a healthcare centre (n = 26), between January 2012 and December 2014. We measured breast volumes (n = 52) based on chest computed tomography (CT) of all patients using Image J software and divided them into four groups according to the side and presence of pectus excavatum. The mean volumes of the right and left breasts of patients with pectus excavatum were 209 ± 64 mL and 218 ± 67 mL, respectively, with no significant difference between the two groups (P = 0.736). The mean volumes of the right and left breasts of normal women were 415 ± 197 mL and 439 ± 197 mL, respectively, with no significant difference between the two groups (P = 0.754). The breasts of patients with pectus excavatum were significantly smaller than those of normal women (P pectus excavatum were similar in size but were smaller than the breasts of normal women. Skeletal correction for breast asymmetry correction, followed by breast augmentation for breast hypoplasty correction, with a one- or two-step approach may be useful to improve the aesthetics of breast deformities in women with pectus excavatum.

  11. [Changes in mood caused by staged, moderate physical activity]. (United States)

    Otto, J; Stemmann, O


    This experiment provides a test for the common sense knowledge that moderate physical exercise leads to mood improvement. Furthermore, it was tested whether light exercise intensifies negative feeling states or alleviates them. 30 female and 30 male students of psychology served as subjects (mean age 25.3 years, SD = 4.8). After being exposed to a mood induction procedure designed to elicit either a positive or negative feeling state, the subjects had to pedal a bicycle ergometer with 0, 50 or 75 Watt load. Cardiovascular variables and self-reports of mood states were assessed during a baseline period, after the mood induction, following the ergometer exercise, and after a follow-up period. The mood induction procedures were successful, but only for a short duration. Physiological activation was observed according to the ergometer loadings. Moderate physical exercise led to an increase of positive feeling states (Concentration) and a decrease of negative feeling states (Tiredness) in the follow-up period. Corresponding changes in tension related states could not be observed, probably due to the weakness of the mood induction procedure employed and the low level of energetic activation reached.

  12. Red cell volume with changes in plasma osmolarity during maximal exercise. (United States)

    Van Beaumont, W.


    The volume of the red cell in vivo was measured during acute changes in plasma osmolarity evoked through short (6 to 8 min) maximal exercise in six male volunteer subjects. Simultaneous measurements of mean corpuscular red cell volume (MCV), hematocrit, blood hemoglobin, mean corpuscular hemoglobin concentration (MCHC), and plasma osmolarity showed that there was no change in the MCV or MCHC with a concomitant rise of nearly 6% in plasma osmolarity. Apparently, in vivo, the volume of the red cell in exercising healthy human subjects does not change measurably, in spite of significant changes in osmotic pressure of the surrounding medium. Consequently, it is not justified to correct postexercise hematocrit measurements for changes in plasma osmolarity.

  13. Do Acartia tonsa (Dana) eggs regulate their volume and osmolality as salinity changes?

    DEFF Research Database (Denmark)

    Hansen, Benni Winding; Drillet, Guillaume; Pedersen, Morten Foldager;


    Subitaneous eggs from an euryhaline calanoid copepod Acartia tonsa were challenged by changes in salinity within the range from full strength salinity, down to zero and up to >70 psu. Egg volume changed immediately, increasing from 2.8 × 105 μm3 at full strength salinity (35 psu) to 3.8 × 105 μm3...... at 0 psu and back to its initial volume when gradually being returned to full strength salinity. Egg osmolality followed the molality of the surrounding water when challenged within a salinity range from 2 to 50 psu. Egg respiration was not affected when eggs kept at 35 psu was exposed to low salinity...... (2 psu). These results suggest that eggs are unable to regulate their volume or osmolality when challenged with changes in salinity. Gradual changes in salinity from 35 to 2 psu and back did not harm the eggs (embryos), since the hatching success remained unaffected by such changes in salinity...

  14. Red cell volume with changes in plasma osmolarity during maximal exercise. (United States)

    Van Beaumont, W.


    The volume of the red cell in vivo was measured during acute changes in plasma osmolarity evoked through short (6 to 8 min) maximal exercise in six male volunteer subjects. Simultaneous measurements of mean corpuscular red cell volume (MCV), hematocrit, blood hemoglobin, mean corpuscular hemoglobin concentration (MCHC), and plasma osmolarity showed that there was no change in the MCV or MCHC with a concomitant rise of nearly 6% in plasma osmolarity. Apparently, in vivo, the volume of the red cell in exercising healthy human subjects does not change measurably, in spite of significant changes in osmotic pressure of the surrounding medium. Consequently, it is not justified to correct postexercise hematocrit measurements for changes in plasma osmolarity.

  15. Impact of the volume change on the ageing effects in Cu-Al-Ni martensite: experiment and theory. (United States)

    Kosogor, Anna; Xue, Dezhen; Zhou, Yumei; Ding, Xiangdong; Otsuka, Kazuhiro; L'vov, Victor A; Sun, Jun; Ren, Xiaobing


    The time evolution of the physical properties of martensite during martensite ageing is traditionally explained by the symmetry-conforming short-range order (SC-SRO) principle, which requires the spatial configuration of crystal defects to follow the symmetry change of the host lattice. In the present study, we show that the volume change of the host lattice also contributes to the ageing effects in Cu-Al-Ni shape memory alloy besides the symmetry change. To substantiate this statement the gradual increase of the storage modulus with time at constant temperature was measured by dynamic mechanical analysis (DMA) and the experimental results were quantitatively described in the framework of the symmetry-conforming Landau theory of martensitic transformations in a crystal with defects. The comparison of experimental and theoretical results confirmed that the time dependence of the storage modulus is caused by two different physical mechanisms. Evaluations showing that the first mechanism is driven by the spontaneous symmetry change and the second mechanism is caused by the volume change after the martensitic transformation was carried out.

  16. Cell volume changes affect gluconeogenesis in the perfused liver of the catfish Clarias batrachus

    Indian Academy of Sciences (India)

    Carina Goswami; Shritapa Datta; Kuheli Biswas; Nirmalendu Saha


    In addition to lactate and pyruvate, some amino acids were found to serve as potential gluconeogenic substrates in the perfused liver of Clarias batrachus. Glutamate was found to be the most effective substrate, followed by lactate, pyruvate, serine, ornithine, proline, glutamine, glycine, and aspartate. Four gluconeogenic enzymes, namely phosphoenolpyruvate carboxykinase (PEPCK), pyruvate carboxylase (PC), fructose 1,6-bisphosphatase (FBPase) and glucose 6-phosphatase (G6Pase) could be detected mainly in liver and kidney, suggesting that the latter are the two major organs responsible for gluconeogenic activity in this fish. Hypo-osmotically induced cell swelling caused a significant decrease of gluconeogenic efflux accompanied with significant decrease of activities of PEPCK, FBPase and G6Pase enzymes in the perfused liver. Opposing effects were seen in response to hyper-osmotically induced cell shrinkage. These changes were partly blocked in the presence of cycloheximide, suggesting that the aniso-osmotic regulations of gluconeogenesis possibly occurs through an inverse regulation of enzyme proteins and/or a regulatory protein synthesis in this catfish. In conclusion, gluconeogenesis appears to play a vital role in C. batrachus in maintaining glucose homeostasis, which is influenced by cell volume changes possibly for proper energy supply under osmotic stress.

  17. On-line dynamic measurement of blood viscosity, hematocrit and change of blood volume

    Institute of Scientific and Technical Information of China (English)


    Objective: To develop an on-line system for the measurement of blood viscosity and hematocrit. The dynamic changes of the macrovascular blood volumes,microvascular blood volumes and the total blood volume were observed by means of calculating from the testing result. Methods: Applying traditional viscosity measurement principle and specific wavelength optic density measurement method, an on-line system for the measurement of blood viscosity and hematocrit was developed, and the A/D multifunctionai board and the testing circuit were designed by ourselves. The system was validated by experiments both in vitro and in vivo. Therapeutic effects of hypertonic saline dextran solution (HSD) and Lactatic Ringer's solution at the early stage after burn-blast combined injury were compared by this method. Results: The results showed that the system has attained the goal of the design. The changes of the blood viscosity and hematocrit could be detected effectively and continuously. The changes of macrovascular, microvascular and total blood volume could be calculated approximately. Conclusions: The system and the method can continuously on-line test the blood viscosity and hematocrit, and reveal the change and distribution of blood volumes more accurately and dearly in the therapy process by estimating changes of the macrovascular, microvascular and total blood volumes, respectively. It has confirmed that HSD treatment could increase blood pressure and attenuate tissue edema by significantly increasing total blood volume,improving macrocirculatory and microcirculatory blood volumes. This study suggested that it could be desirable to develop an experiment technique based on the method mentioned above.

  18. Evidence for the changes of pituitary volumes in patients with post-traumatic stress disorder. (United States)

    Atmaca, Murad; Ozer, Omer; Korkmaz, Sevda; Taskent, Ismail; Yildirim, Hanefi


    In pubertal and postpubertal patients with post-traumatic stress disorder (PTSD), significantly greater pituitary gland volumes have been reported. Moving from this point, in the present study, we aimed to investigate pituitary gland volumes in patients with PTSD and hypothesized that volumes of the gland would be structurally changed. Volumetric magnetic resonance imaging of the pituitary gland was performed among sixteen patients with PTSD and fifteen healthy control subjects. We found that the mean volume of the pituitary gland was statistically significant and smaller than that of healthy subjects (0.69±0.08cm(3) for patient group and 0.83±0.21 for control subjects). Consequently, in the present study, we found that patients with PTSD had smaller pituitary gland volumes than those of healthy controls like other anxiety disorders. It is important to provide support for this finding in future longitudinal investigations. Copyright © 2016. Published by Elsevier B.V.

  19. Quantification of cerebral ventricle volume change of preterm neonates using 3D ultrasound images (United States)

    Chen, Yimin; Kishimoto, Jessica; Qiu, Wu; de Ribaupierre, Sandrine; Fenster, Aaron; Chiu, Bernard


    Intraventricular hemorrhage (IVH) is a major cause of brain injury in preterm neonates. Quantitative measurement of ventricular dilation or shrinkage is important for monitoring patients and in evaluation of treatment options. 3D ultrasound (US) has been used to monitor the ventricle volume as a biomarker for ventricular dilation. However, volumetric quantification does not provide information as to where dilation occurs. The location where dilation occurs may be related to specific neurological problems later in life. For example, posterior horn enlargement, with thinning of the corpus callosum and parietal white matter fibres, could be linked to poor visuo-spatial abilities seen in hydrocephalic children. In this work, we report on the development and application of a method used to analyze local surface change of the ventricles of preterm neonates with IVH from 3D US images. The technique is evaluated using manual segmentations from 3D US images acquired in two imaging sessions. The surfaces from baseline and follow-up were registered and then matched on a point-by-point basis. The distance between each pair of corresponding points served as an estimate of local surface change of the brain ventricle at each vertex. The measurements of local surface change were then superimposed on the ventricle surface to produce the 3D local surface change map that provide information on the spatio-temporal dilation pattern of brain ventricles following IVH. This tool can be used to monitor responses to different treatment options, and may provide important information for elucidating the deficiencies a patient will have later in life.

  20. Large–scale geographical variation confirms that climate change causes birds to lay earlier

    National Research Council Canada - National Science Library

    Christiaan Both; Aleksandr V. Artemyev; Bert Blaauw; Richard J. Cowie; Aarnoud J. Dekhuijzen; Tapio Eeva; Anders Enemar; Lars Gustafsson; Elena V. Ivankina; Antero Järvinen; Neil B. Metcalfe; N. Erik I. Nyholm; Jaime Potti; Pierre-Alain Ravussin; Juan Jose Sanz; Bengt Silverin; Fred M. Slater; Leonid V. Sokolov; János Török; Wolfgang Winkel; Jonathan Wright; Herwig Zang; Marcel E. Visser


    Advances in the phenology of organisms are often attributed to climate change, but alternatively, may reflect a publication bias towards advances and may be caused by environmental factors unrelated to climate change...

  1. Ultrasound as a Noninvasive Method to Assess Changes of Intracranial Volume and Pressure During Simulated Microgravity (United States)

    Murthy, G.; Yost, W. T.; Ballard, R. E.; Watenpaugh, D. E.; Kawai, Y.; Hargens, A. R.


    Headaches are commonly experienced by astronauts in microgravity and by subjects undergoing head-down tilt (simulated microgravity on Earth). Exposure to microgravity probably elevates blood pressure and flow in the head which may increase intracranial volume (ICV) and pressure (ICP) and in turn cause headache. Due to the slightly compliant nature of the cranial vault and the encasement of brain and its vasculature within this vault, any increase of ICV will increase ICP and slightly distend the cranium. Previous studies document perivascular edema and increased ICP in rhesus monkeys during head-down tilt. Elevated ICP has also been reported in humans during head-down tilt. ICP measurements in healthy humans are rare because of the invasiveness of currently-available measurement techniques. Therefore, we proposed a noninvasive ultrasound technique to assess changes of ICV and JCP. The ultrasound principle is based on compliance of the cranial vault. A 450 kHz ultrasound stimulus is transmitted through the cranium by a transducer every 7.5-10 msec. The ultrasound wave enters the brain tissue, reflects off the opposite side of the cranium and is received by the same transducer. The detected wave is compared for phase quadrature (90 transmitted wave). Because the electronic circuitry of the device maintains a 90 deg. phase (phi), any alterations in the detected wave caused by an increase of ICV and ICP will be reflected as a change in the wave frequency. Phase shift is directly proportional to path length of the wave, DELTA x, which is expressed as DELTA x = phi lambda/2 pi where lambda is wavelength. Elevated ICV and ICP expand the cranial vault and increase path length of the wave (a measure of intracranial distance). Increased path length equals reduced frequency of the detected wave. Reduced frequency is then related to elevated ICP. This technique has potential uses for ICP studies of astronauts in space and head trauma patients on Earth.

  2. Changes in superior mesenteric artery Doppler waveform during reduction of cardiac stroke volume and hypotension

    DEFF Research Database (Denmark)

    Perko, M J; Perko, Grazyna; Just, S


    Influence of stroke volume reduction and hypotension on the superior mesenteric artery (SMA) Doppler waveform was evaluated during head-up tilt-induced central hypovolemia in 11 healthy volunteers. During normotensive reduction in stroke volume, peak systolic velocity (pV), mean velocity, pulsati......Influence of stroke volume reduction and hypotension on the superior mesenteric artery (SMA) Doppler waveform was evaluated during head-up tilt-induced central hypovolemia in 11 healthy volunteers. During normotensive reduction in stroke volume, peak systolic velocity (pV), mean velocity...... of the study indicate that alterations in stroke volume induce consequential changes in the SMA Doppler waveform. These changes originate from both direct influence of stroke volume and/or pressure on blood flow velocity, and alterations in SMA peripheral resistance that follow variations in stroke volume....... Presented interdependencies should be taken into consideration while studying mesenteric physiology with the use of Doppler technique and while interpreting the duplex results in patients suffering from diseases that may influence flow velocity and mimic or obscure Doppler effects of the SMA stenosis....

  3. Longitudinal changes in hippocampal volumes and cognition in remitted geriatric depressive disorder. (United States)

    Hou, Zhenghua; Yuan, Yonggui; Zhang, Zhijun; Bai, Feng; Hou, Gang; You, Jiayong


    Growing evidences suggest that the abnormality of hippocampal volume may occur in the process of depression. In this longitudinal study, we calculated the hippocampal volume of 14 remitted geriatric depressed (RGD) patients and 19 healthy participants at baseline and follow-up. We found significant improvement of performance in Trail Making Test-A (P=0.038) and Test-B (P=0.032), and the right hippocampal volume increased mildly in RGD. However, in RGD patients, positive correlations were seen between the changes in right hippocampal volumes and Symbol Digit Modality Test scores (r=0.675, P=0.008), and changes in left hippocampal volumes and Mini-Mental State Examination scores (r=0.743, P=0.002). Our findings suggest that hippocampus related cognitive impairment and previously addressed decreased hippocampal volume might represent a state rather than a permanent trait of the depressive disorder. The results suggest that hippocampal volume may be a useful risk marker for conversion to Alzheimer's disease in RGD patients. Additionally, our study indicates that effective antidepressants treatment might postpone and even revise the deterioration of hippocampus to some degree. Copyright © 2011 Elsevier B.V. All rights reserved.

  4. Modulation of KCNQ4 channel activity by changes in cell volume

    DEFF Research Database (Denmark)

    Hougaard, Charlotte; Klaerke, Dan A; Hoffmann, Else K;


    KCNQ4 channels expressed in HEK 293 cells are sensitive to cell volume changes, being activated by swelling and inhibited by shrinkage, respectively. The KCNQ4 channels contribute significantly to the regulatory volume decrease (RVD) process following cell swelling. Under isoosmotic conditions......, the KCNQ4 channel activity is modulated by protein kinases A and C, G protein activation, and a reduction in the intracellular Ca2+ concentration, but these signalling pathways are not responsible for the increased channel activity during cell swelling....

  5. InSAR elevation bias caused by penetration into uniform volumes

    DEFF Research Database (Denmark)

    Dall, Jørgen


    SAR) biased downward. For infinitely deep uniform volumes, the elevation bias is often equated with the penetration depth, but this paper, it is shown that the two quantities generally differ. The interferometric bias is approximately equal to the two-way power-penetration depth if the latter is small......Natural media like cold-land ice, vegetation, and dry sand are subject to a substantial penetration at microwave frequencies. For such media, the synthetic aperture radar (SAR) ase center is located below the surface, and consequently, the surface elevation determined with SAR interferometry (In...... compared to the ambiguity height, but for increasing penetration depth, the bias approaches one quarter of the ambiguity height. Consequently, phase wrapping results even if the penetration depth exceeds ambiguity height. The ratio of the InSAR elevation bias to ambiguity height depends only on the ratio...

  6. Temporal dynamics and determinants of whole brain tissue volume changes during recovery from alcohol dependence. (United States)

    Gazdzinski, Stefan; Durazzo, Timothy C; Meyerhoff, Dieter J


    Brain shrinkage and its partial reversibility with abstinence is a common neuroimaging finding in alcohol dependent individuals. We used an automated three-dimensional whole brain magnetic resonance imaging method (boundary shift integral) in 23 alcohol dependent individuals to measure the temporal dynamics of cerebral tissue and spinal fluid volume changes over a 12-month interval and to examine the major determinants of brain tissue change rates during abstinence and non-abstinence. We found more rapid brain tissue gain during the first month of sobriety than in the following months. The most rapid volume recovery was observed in abstinent individuals with the greatest baseline brain shrinkage and drinking severity. The rapid reversal of brain volume gains in non-abstinent individuals and tissue volume changes are modulated by duration of abstinence and non-abstinence periods, as well as recency of non-abstinence. Age, family history density of alcoholism, relapse severity, and duration or age of onset of heavy drinking were not major determinants of brain shrinkage and brain volume recovery rates. Treatment providers may use this tangible information to reinforce the biomedical benefits of sobriety. Previous quantitative measurements of brain volumes in alcohol dependent individuals performed after several weeks of abstinence likely underestimated the full extent of chronic alcohol-associated brain shrinkage.

  7. Effects of prenatal alcohol exposure on the development of white matter volume and change in executive function

    Directory of Open Access Journals (Sweden)

    P. Gautam


    Full Text Available Prenatal alcohol exposure can cause a wide range of deficits in executive function that persist throughout life, but little is known about how changes in brain structure relate to cognition in affected individuals. In the current study, we predicted that the rate of white matter volumetric development would be atypical in children with fetal alcohol spectrum disorders (FASD when compared to typically developing children, and that the rate of change in cognitive function would relate to differential white matter development between groups. Data were available for 103 subjects [49 with FASD, 54 controls, age range 6–17, mean age = 11.83] with 153 total observations. Groups were age-matched. Participants underwent structural magnetic resonance imaging (MRI and an executive function (EF battery. Using white matter volumes measured bilaterally for frontal and parietal regions and the corpus callosum, change was predicted by modeling the effects of age, intracranial volume, sex, and interactions with exposure status and EF measures. While both groups showed regional increases in white matter volumes and improvement in cognitive performance over time, there were significant effects of exposure status on age-related relationships between white matter increases and EF measures. Specifically, individuals with FASD consistently showed a positive relationship between improved cognitive function and increased white matter volume over time, while no such relationships were seen in controls. These novel results relating improved cognitive function with increased white matter volume in FASD suggest that better cognitive outcomes could be possible for FASD subjects through interventions that enhance white matter plasticity.

  8. Adaptation approaches for conserving ecosystems services and biodiversity in dynamic landscapes caused by climate change (United States)

    Oswald J. Schmitz; Anne M. Trainor


    Climate change stands to cause animal species to shift their geographic ranges. This will cause ecosystems to become reorganized across landscapes as species migrate into and out of specific locations with attendant impacts on values and services that ecosystems provide to humans. Conservation in an era of climate change needs to ensure that landscapes are resilient by...

  9. An international comparison of the causes of changes in the debt service ratio 1980-1985

    Directory of Open Access Journals (Sweden)



    Full Text Available The forces leading up to the debt crisis of the 1980s go back a long way. As a country experiences a rising ratio of debt service payments to export earnings so its default risk increases. World indicators show that interest rates were on a rising trend when commodity prices were on a downward trend. However, this is a simplistic analysis. The authors disaggregate the ratio into five components: a change in the volume of debt; a change in the rate of amortisation; a change in the rate of interest; a change in the volume of exports; a change in the price of exports. The article examines these independently in the light of the available data. Results suggest that rescheduling policy is uncoordinated and that debt-management methods can be improved.

  10. Finite volume analysis of temperature effects induced by active MRI implants: 2. Defects on active MRI implants causing hot spots

    Directory of Open Access Journals (Sweden)

    Grönemeyer Dietrich HW


    Full Text Available Abstract Background Active magnetic resonance imaging implants, for example stents, stent grafts or vena cava filters, are constructed as wireless inductively coupled transmit and receive coils. They are built as a resonator tuned to the Larmor frequency of a magnetic resonance system. The resonator can be added to or incorporated within the implant. This technology can counteract the shielding caused by eddy currents inside the metallic implant structure. This may allow getting diagnostic information of the implant lumen (in stent stenosis or thrombosis for example. The electro magnetic rf-pulses during magnetic resonance imaging induce a current in the circuit path of the resonator. A by material fatigue provoked partial rupture of the circuit path or a broken wire with touching surfaces can set up a relatively high resistance on a very short distance, which may behave as a point-like power source, a hot spot, inside the body part the resonator is implanted to. This local power loss inside a small volume can reach ¼ of the total power loss of the intact resonating circuit, which itself is proportional to the product of the resonator volume and the quality factor and depends as well from the orientation of the resonator with respect to the main magnetic field and the imaging sequence the resonator is exposed to. Methods First an analytical solution of a hot spot for thermal equilibrium is described. This analytical solution with a definite hot spot power loss represents the worst case scenario for thermal equilibrium inside a homogeneous medium without cooling effects. Starting with this worst case assumptions additional conditions are considered in a numerical simulation, which are more realistic and may make the results less critical. The analytical solution as well as the numerical simulations use the experimental experience of the maximum hot spot power loss of implanted resonators with a definite volume during magnetic resonance imaging

  11. Thermal Volume Change of Unsaturated Silt under Different Stress States and Suction Magnitudes

    Directory of Open Access Journals (Sweden)

    McCartney John S.


    Full Text Available This paper presents an evaluation of the thermal volume change of compacted specimens of the same type of silt under a wide range of stress states, initial void ratios, and suction magnitudes. Stress states include both isotropic and anisotropic conditions with varying principal stress ratios, as well as normally consolidated and overconsolidated conditions. Initial void ratios range from 0.60 to 0.86, spanning very dense to loose conditions. Suctions evaluated range from saturated conditions, to low suctions in the funicular range, to suctions corresponding to residual saturation conditions. For the same soil, wide variations in thermal volume change are observed. Thermal contraction is observed for normally consolidated conditions regardless of the initial degree of saturation. Different mechanisms of thermal volume change can be used to explain the results, ranging from thermally-induced pore water pressure dissipation, to thermal collapse, to thermally-accelerated creep.

  12. Brain putamen volume changes in newly-diagnosed patients with obstructive sleep apnea. (United States)

    Kumar, Rajesh; Farahvar, Salar; Ogren, Jennifer A; Macey, Paul M; Thompson, Paul M; Woo, Mary A; Yan-Go, Frisca L; Harper, Ronald M


    Obstructive sleep apnea (OSA) is accompanied by cognitive, motor, autonomic, learning, and affective abnormalities. The putamen serves several of these functions, especially motor and autonomic behaviors, but whether global and specific sub-regions of that structure are damaged is unclear. We assessed global and regional putamen volumes in 43 recently-diagnosed, treatment-naïve OSA (age, 46.4 ± 8.8 years; 31 male) and 61 control subjects (47.6 ± 8.8 years; 39 male) using high-resolution T1-weighted images collected with a 3.0-Tesla MRI scanner. Global putamen volumes were calculated, and group differences evaluated with independent samples t-tests, as well as with analysis of covariance (covariates; age, gender, and total intracranial volume). Regional differences between groups were visualized with 3D surface morphometry-based group ratio maps. OSA subjects showed significantly higher global putamen volumes, relative to controls. Regional analyses showed putamen areas with increased and decreased tissue volumes in OSA relative to control subjects, including increases in caudal, mid-dorsal, mid-ventral portions, and ventral regions, while areas with decreased volumes appeared in rostral, mid-dorsal, medial-caudal, and mid-ventral sites. Global putamen volumes were significantly higher in the OSA subjects, but local sites showed both higher and lower volumes. The appearance of localized volume alterations points to differential hypoxic or perfusion action on glia and other tissues within the structure, and may reflect a stage in progression of injury in these newly-diagnosed patients toward the overall volume loss found in patients with chronic OSA. The regional changes may underlie some of the specific deficits in motor, autonomic, and neuropsychologic functions in OSA.

  13. Brain putamen volume changes in newly-diagnosed patients with obstructive sleep apnea

    Directory of Open Access Journals (Sweden)

    Rajesh Kumar


    Full Text Available Obstructive sleep apnea (OSA is accompanied by cognitive, motor, autonomic, learning, and affective abnormalities. The putamen serves several of these functions, especially motor and autonomic behaviors, but whether global and specific sub-regions of that structure are damaged is unclear. We assessed global and regional putamen volumes in 43 recently-diagnosed, treatment-naïve OSA (age, 46.4 ± 8.8 years; 31 male and 61 control subjects (47.6 ± 8.8 years; 39 male using high-resolution T1-weighted images collected with a 3.0-Tesla MRI scanner. Global putamen volumes were calculated, and group differences evaluated with independent samples t-tests, as well as with analysis of covariance (covariates; age, gender, and total intracranial volume. Regional differences between groups were visualized with 3D surface morphometry-based group ratio maps. OSA subjects showed significantly higher global putamen volumes, relative to controls. Regional analyses showed putamen areas with increased and decreased tissue volumes in OSA relative to control subjects, including increases in caudal, mid-dorsal, mid-ventral portions, and ventral regions, while areas with decreased volumes appeared in rostral, mid-dorsal, medial-caudal, and mid-ventral sites. Global putamen volumes were significantly higher in the OSA subjects, but local sites showed both higher and lower volumes. The appearance of localized volume alterations points to differential hypoxic or perfusion action on glia and other tissues within the structure, and may reflect a stage in progression of injury in these newly-diagnosed patients toward the overall volume loss found in patients with chronic OSA. The regional changes may underlie some of the specific deficits in motor, autonomic, and neuropsychologic functions in OSA.

  14. [Mean Platelet Volume in Children with Acute Gastroenteritis Caused by Entamoeba histolytica]. (United States)

    Çelik, Tanju; Güler, Ekrem; Berksoy, Emel Ataş; Sorguç, Yelda; Arslan, Nur


    Mean platelet volume (MPV) is a marker of platelet activation, which is a determinant of inflammation. The first aim of the present study was to investigate the MPV levels in children with amebiasis and compare the MPV levels with healthy controls. The second aim of this study was to evaluate the relationship between MPV and other acute phase reactants. Seventy six patients with amebic gastroenteritis (mean age 2.64 ± 0.23 years) and 53 healthy controls (mean age 2.35 ± 0.28 years) were enrolled in the study. Entamoeba histolytica was determined in stool using rapid antigen test. Complete blood count and C-reactive protein (CRP) levels were assessed for all children. MPV levels of patients with amebiasis were significantly higher than those of control children (8.79 ± 0.09 vs. 7.87 ± 0.09 fL, p = 0.000). Leukocyte and eosinophil counts, C-reactive protein and creatinine levels of the patients were higher than controls. Leukocyte count was positively correlated with MPV (r = 0.192, p amebiasis compared to controls. MPV can be used as an acute phase reactant in children with Entamoeba histolytica gastroenteritis.

  15. Electrolyte and Haemogram changes post large volume liposuction comparing two different tumescent solutions

    Directory of Open Access Journals (Sweden)

    Kumar Vivek


    Full Text Available Background: The most common definitions of large volume liposuction refer to total 5 l volume aspiration during a single procedure (fat plus wetting solution. Profound haemodynamic and metabolic alterations can accompany large volume liposuction. Due to paucity of literature on the effect of different tumescent solutions on the electrolyte balance and haematological changes during large volume liposuction, we carried out this study using two different wetting solutions to study the same. Materials and Methods: Total 30 patients presenting with varying degrees of localized lipodystrophy in different body regions were enrolled for the study. Prospective randomized controlled trial was conducted by Department of Plastic and Cosmetic Surgery, Sir Ganga Ram Hospital, New Delhi from January 2011 to June 2012. Patients were randomized into two groups of 15 patients each by using computer generated random numbers. Tumescent formula used for Group A (normal saline [NS] was our modification of Klein′s Formula and Tumescent formula used for Group B (ringer lactate [RL] was our modification of Hunstadt′s formula. Serum electrolytes and hematocrit levels were done at preinduction, immediate postoperative period and postoperative day 1. Result: Statistical analysis was performed using SPSS software version 15.0. Which showed statistically significant electrolytes and hematocrit changes occur during large volume liposuction. Conclusion: Statistically significant electrolytes and hematocrit changes occur during large volume liposuction and patients should be kept under observation of anaesthesist for at least 24 h. Patients require strict monitoring of vital parameters and usually Intensive Care Unit is not required. There was no statistical difference in the electrolyte changes using NS or RL as tumescent solution and both solutions were found safe for large volume liposuction.

  16. Excluded volume effects caused by high concentration addition of acid generators in chemically amplified resists used for extreme ultraviolet lithography (United States)

    Kozawa, Takahiro; Watanabe, Kyoko; Matsuoka, Kyoko; Yamamoto, Hiroki; Komuro, Yoshitaka; Kawana, Daisuke; Yamazaki, Akiyoshi


    The resolution of lithography used for the high-volume production of semiconductor devices has been improved to meet the market demands for highly integrated circuits. With the reduction in feature size, the molecular size becomes non-negligible in the resist material design. In this study, the excluded volume effects caused by adding high-concentration acid generators were investigated for triphenylsulfonium nonaflate. The resist film density was measured by X-ray diffractometry. The dependences of absorption coefficient and protected unit concentration on acid generator weight ratio were calculated from the measured film density. Using these values, the effects on the decomposition yield of acid generators, the protected unit fluctuation, and the line edge roughness (LER) were evaluated by simulation on the basis of sensitization and reaction mechanisms of chemically amplified extreme ultraviolet resists. The positive effects of the increase in acid generator weight ratio on LER were predominant below the acid generator weight ratio of 0.3, while the negative effects became equivalent to the positive effects above the acid generator weight ratio of 0.3 owing to the excluded volume effects.


    Directory of Open Access Journals (Sweden)

    Shōbo A


    Full Text Available Background: Poor posture is detrimental to breathing. Our purpose was to investigate the effect of upright and hunchbacked sitting on thoracic configuration and changes in the volume of the thorax during quiet and volitional deep breathing. Methods: The participants were 11 healthy men with a mean age of 21.6 years, mean body mass of 59.8 kg, mean height of 169.7 cm and a body mass index of 20.7 kg/m2. Eighty-four reflective markers were placed on the trunk. Three-dimensional motion analysis measured the volume within the hemithoraces. To calculate upper and lower thoracic volumes, six imaginary hexahedra were visualized using four reflective markers for each on both aspects of the thorax. Each hexahedron was divided into three imaginary triangular pyramids to calculate positional vectors. Finally, the volume for the hexahedra and triangular pyramids was calculated. Upper thoracic volume encompassed a space from the sternal notch to a midpoint on the ventral aspect of the third rib and the lower thoracic volume from the xiphoid process to the midpoint on tenth rib’s dorsal aspect. Results: In hunchbacked sitting during quiet breathing the left lower hemithorax yielded a significantly larger volume (p=0.003, and both breathing patterns during inspiration and expiration yielded a significantly greater change in thoracic configuration (p=0.01, p=0.016. Conclusion: Findings suggested that, in a hunchbacked sitting, there was decreased thoracic asymmetry with re-establishment of thoracic vertebral alignment, consequently stabilizing the sitting position, but breathing was suppressed and tidal volume decreased. Physiotherapy should aim at ensuring correction of hunchbacked posture and maintenance of thoracic symmetry.

  18. Dynamic cortical gray matter volume changes after botulinum toxin in cervical dystonia

    NARCIS (Netherlands)

    Delnooz, C.C.S.; Pasman, J.W.; Warrenburg, B.P.C. van de


    Previous electrophysiological and functional imaging studies in focal dystonia have reported on cerebral reorganization after botulinum toxin (BoNT) injections. With the exception of microstructural changes, alterations in gray matter volume after BoNT have not been explored. In this study, we

  19. Surprising volume change in PPy(DBS): An atomic force microscopy study

    DEFF Research Database (Denmark)

    Smela, E.; Gadegaard, N.


    Communication: Conjugated polymers such as polypyrrole (PPy) have potential use as artificial muscles or in microsystems such as valves for micro-fluid handling. One of the most important parameters in such uses is the magnitude of volume change during associated redox processes; however, until now...

  20. Changes in forced expiratory volume in 1 second over time in COPD

    DEFF Research Database (Denmark)

    Vestbo, Jørgen; Edwards, Lisa D; Scanlon, Paul D


    A key feature of chronic obstructive pulmonary disease (COPD) is an accelerated rate of decline in forced expiratory volume in 1 second (FEV(1)), but data on the variability and determinants of this change in patients who have established disease are scarce....

  1. Changes in forced expiratory volume in 1 second over time in COPD

    DEFF Research Database (Denmark)

    Vestbo, Jørgen; Edwards, Lisa D; Scanlon, Paul D


    A key feature of chronic obstructive pulmonary disease (COPD) is an accelerated rate of decline in forced expiratory volume in 1 second (FEV(1)), but data on the variability and determinants of this change in patients who have established disease are scarce....

  2. Age-related changes in body fluid volumes in young spontaneously hypertensive rats

    Energy Technology Data Exchange (ETDEWEB)

    Von Dreele, M.M. (Wright State Univ., Dayton, OH (USA))


    The authors have measured total body water (TBW, by dessiccation), extracellular fluid volume (ECF, Na{sub 2}{sup 35}SO{sub 4} space), and plasma volume (PV, radioiodinated serum albumin space) in 5-sec-butyl-5-ethyl-2-thiobarbituric acid and sodium salt (Inactin)-anesthetized spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats aged 12-60 days. Interstitial fluid volume (ISF) was calculated as ECF minus PV. Changes in TBW, ECF, and ISF were largely a function of age in both strains, which is typical of developing mammals. Further analysis revealed that although these volumes were significantly larger in SHR before 25 days of age, after 30 days no difference existed between the strains. Before 25 days of age, when SHR's TBW was expanded, no weight difference was seen between the strains. However, once TBW was normalized (after 30 days), WKY was significantly heavier than SHR. The ISF volume was preferentially enlarged in SHR, although PV was also periodically greater. ISF normalized at the time when blood pressure becomes significantly higher in SHR, when plasma aldosterone falls to WKY values in SHR and when renal function is approaching adult levels. Thus the return of ECF (ISF) to normal values may be a result of decreased aldosterone-dependent volume retention or to diuresis induced by increasing blood pressure in an animal whose renal function is close to maturity.

  3. Causes and Effects of Change Orders on Construction Projects in Kuwait

    Directory of Open Access Journals (Sweden)

    Alia Alaryan


    Full Text Available This research investigates the change orders in public and private construction projects in Kuwait. The study in this research presents the results of a questionnaire surveying the owners, contractors and consultants on a sample comprising 385 engineers representing the construction industry. The responses to the questionnaire help in identifying the general characteristics of the construction industry in Kuwait as well as ranking the most common causes of changes, their effects on the projects and the control measures to address the changes. The results of the questionnaire indicate that the owner is the most responsible party causing changes. The study identifies that the first cause is change of plans by owner, otherwise increase in cost of the project is the first effect. All changes to design documents are checked and reviewed is the first control.

  4. Changes in extracellular muscle volume affect heart rate and blood pressure responses to static exercise (United States)

    Baum, K.; Essfeld, D.; Stegemann, J.

    To investigate the effect of μg-induced peripheral extracellular fluid reductions on heart rate and blood pressure during isometric exercise, six healthy male subjects performed three calf ergometer test with different extracellular volumes of working muscles. In all tests, body positions during exercise were identical (supine with the knee joint flexed to 900). After a pre-exercise period of 25 min, during which calf volumes were manipulated, subjects had to counteract an external force of 180 N for 5 min. During the pre-exercise period three different protocols were applied. Test A: Subjects rested in the exercise position; test B: Body position was the same as in A but calf volume was increased by venous congestion (cuffs inflated to 80 mm Hg); test C: Calf volumes were decreased by a negative hydrostatic pressure (calves about 40 cm above heart level with the subjects supine). To clamp the changed calf volumes in tests B and C, cuffs were inflated to 300 mm Hg 5 min before the onset of exercise. This occlusion was maintained until termination of exercise. Compared to tests A and B, the reduced volume of test C led to significant increases in heart rate and blood pressure during exercise. Oxygen uptake did not exceed resting levels in B and C until cuffs were deflated, indicating that exclusively calf muscles contributed to the neurogenic peripheral drive. It is concluded that changes in extracellular muscle volume have to be taken into account when comparing heart rate and blood pressure during lg- and μg- exercise.

  5. Adenovirus-mediated hAQP1 expression in irradiated mouse salivary glands causes recovery of saliva secretion by enhancing acinar cell volume decrease. (United States)

    Teos, L Y; Zheng, C-Y; Liu, X; Swaim, W D; Goldsmith, C M; Cotrim, A P; Baum, B J; Ambudkar, I S


    Head and neck irradiation (IR) during cancer treatment causes by-stander effects on the salivary glands leading to irreversible loss of saliva secretion. The mechanism underlying loss of fluid secretion is not understood and no adequate therapy is currently available. Delivery of an adenoviral vector encoding human aquaporin-1 (hAQP1) into the salivary glands of human subjects and animal models with radiation-induced salivary hypofunction leads to significant recovery of saliva secretion and symptomatic relief in subjects. To elucidate the mechanism underlying loss of salivary secretion and the basis for AdhAQP1-dependent recovery of salivary gland function we assessed submandibular gland function in control mice and mice 2 and 8 months after treatment with a single 15-Gy dose of IR (delivered to the salivary gland region). Salivary secretion and neurotransmitter-stimulated changes in acinar cell volume, an in vitro read-out for fluid secretion, were monitored. Consistent with the sustained 60% loss of fluid secretion following IR, a carbachol (CCh)-induced decrease in acinar cell volume from the glands of mice post IR was transient and attenuated as compared with that in cells from non-IR age-matched mice. The hAQP1 expression in non-IR mice induced no significant effect on salivary fluid secretion or CCh-stimulated cell volume changes, except in acinar cells from 8-month group where the initial rate of cell shrinkage was increased. Importantly, the expression of hAQP1 in the glands of mice post IR induced recovery of salivary fluid secretion and a volume decrease in acinar cells to levels similar to those in cells from non-IR mice. The initial rates of CCh-stimulated cell volume reduction in acinar cells from hAQP1-expressing glands post IR were similar to those from control cells. Altogether, the data suggest that expression of hAQP1 increases the water permeability of acinar cells, which underlies the recovery of fluid secretion in the salivary glands

  6. Mechanism of Calcined Phosphogypsum for the Volume Change of Blended Cement

    Institute of Scientific and Technical Information of China (English)


    The paper describes an investigation into the volume change of cement mortar specimen at the three kinds of different curing schedules including 20℃ and 5% Na2SO4 solution curing, tap water standard curing, 50% RH curing for 90 days. The testing results of hydration heat, chemical shrinking and XRD prove that calcined phosphogypsum has evident excitation effect on the activity of high calcium ash and steel slag. Simultaneously, calcined phosphogypsum has the function of decreasing volume shrinkage to blended cement possessing steel slag and high calcium ash. In sulfate curing, calcined phosphogypsum can avoid the phenomenon of protrude apex of the blended cement.

  7. A lattice Boltzmann coupled to finite volumes method for solving phase change problems

    Directory of Open Access Journals (Sweden)

    El Ganaoui Mohammed


    Full Text Available A numerical scheme coupling lattice Boltzmann and finite volumes approaches has been developed and qualified for test cases of phase change problems. In this work, the coupled partial differential equations of momentum conservation equations are solved with a non uniform lattice Boltzmann method. The energy equation is discretized by using a finite volume method. Simulations show the ability of this developed hybrid method to model the effects of convection, and to predict transfers. Benchmarking is operated both for conductive and convective situation dominating solid/liquid transition. Comparisons are achieved with respect to available analytical solutions and experimental results.

  8. Changes in subcutaneous fat cell volume and insulin sensitivity after weight loss. (United States)

    Andersson, Daniel P; Eriksson Hogling, Daniel; Thorell, Anders; Toft, Eva; Qvisth, Veronica; Näslund, Erik; Thörne, Anders; Wirén, Mikael; Löfgren, Patrik; Hoffstedt, Johan; Dahlman, Ingrid; Mejhert, Niklas; Rydén, Mikael; Arner, Erik; Arner, Peter


    Large subcutaneous fat cells associate with insulin resistance and high risk of developing type 2 diabetes. We investigated if changes in fat cell volume and fat mass correlate with improvements in the metabolic risk profile after bariatric surgery in obese patients. Fat cell volume and number were measured in abdominal subcutaneous adipose tissue in 62 obese women before and 2 years after Roux-en-Y gastric bypass (RYGB). Regional body fat mass by dual-energy X-ray absorptiometry; insulin sensitivity by hyperinsulinemic-euglycemic clamp; and plasma glucose, insulin, and lipid profile were assessed. RYGB decreased body weight by 33%, which was accompanied by decreased adipocyte volume but not number. Fat mass in the measured regions decreased and all metabolic parameters were improved after RYGB (P fat cell size correlated strongly with improved insulin sensitivity (P = 0.0057), regional changes in fat mass did not, except for a weak correlation between changes in visceral fat mass and insulin sensitivity and triglycerides. The curve-linear relationship between fat cell size and fat mass was altered after weight loss (P = 0.03). After bariatric surgery in obese women, a reduction in subcutaneous fat cell volume associates more strongly with improvement of insulin sensitivity than fat mass reduction per se. An altered relationship between adipocyte size and fat mass may be important for improving insulin sensitivity after weight loss. Fat cell size reduction could constitute a target to improve insulin sensitivity. © 2014 by the American Diabetes Association.

  9. Volume change determination of metastatic lung tumors in CT images using 3-D template matching (United States)

    Ambrosini, Robert D.; Wang, Peng; O'Dell, Walter G.


    The ability of a clinician to properly detect changes in the size of lung nodules over time is a vital element to both the diagnosis of malignant growths and the monitoring of the response of cancerous lesions to therapy. We have developed a novel metastasis sizing algorithm based on 3-D template matching with spherical tumor appearance models that were created to match the expected geometry of the tumors of interest while accounting for potential spatial offsets of nodules in the slice thickness direction. The spherical template that best-fits the overall volume of each lung metastasis was determined through the optimization of the 3-D normalized cross-correlation coefficients (NCCC) calculated between the templates and the nodules. A total of 17 different lung metastases were extracted manually from real patient CT datasets and reconstructed in 3-D using spherical harmonics equations to generate simulated nodules for testing our algorithm. Each metastasis 3-D shape was then subjected to 10%, 25%, 50%, 75% and 90% scaling of its volume to allow for 5 possible volume change combinations relative to the original size per each reconstructed nodule and inserted back into CT datasets with appropriate blurring and noise addition. When plotted against the true volume change, the nodule volume changes calculated by our algorithm for these 85 data points exhibited a high degree of accuracy (slope = 0.9817, R2 = 0.9957). Our results demonstrate that the 3-D template matching method can be an effective, fast, and accurate tool for automated sizing of metastatic tumors.

  10. 3D mapping of cerebrospinal fluid local volume changes in patients with hydrocephalus treated by surgery: preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Hodel, Jerome [Hopital Roger Salengro, Department of Neuroradiology, Lille (France); Hopital Roger Salengro, Service de Neuroradiologie, Lille (France); Besson, Pierre; Pruvo, Jean-Pierre; Leclerc, Xavier [Hopital Roger Salengro, Department of Neuroradiology, Lille (France); Rahmouni, Alain; Grandjacques, Benedicte; Luciani, Alain [Hopital Henri Mondor, Department of Radiology, Creteil (France); Petit, Eric; Lebret, Alain [Signals Images and Intelligent Systems Laboratory, Creteil (France); Outteryck, Olivier [Hopital Roger Salengro, Department of Neurology, Lille (France); Benadjaoud, Mohamed Amine [Radiation Epidemiology Team, CESP, Centre for Research in Epidemiology and Population Health U1018, Villejuif (France); Maraval, Anne [Hopital Henri Mondor, Department of Neuroradiology, Creteil (France); Decq, Philippe [Hopital Henri Mondor, Department of Neurosurgery, Creteil (France)


    To develop automated deformation modelling for the assessment of cerebrospinal fluid (CSF) local volume changes in patients with hydrocephalus treated by surgery. Ventricular and subarachnoid CSF volume changes were mapped by calculating the Jacobian determinant of the deformation fields obtained after non-linear registration of pre- and postoperative images. A total of 31 consecutive patients, 15 with communicating hydrocephalus (CH) and 16 with non-communicating hydrocephalus (NCH), were investigated before and after surgery using a 3D SPACE (sampling perfection with application optimised contrast using different flip-angle evolution) sequence. Two readers assessed CSF volume changes using 3D colour-encoded maps. The Evans index and postoperative volume changes of the lateral ventricles and sylvian fissures were quantified and statistically compared. Before surgery, sylvian fissure and brain ventricle volume differed significantly between CH and NCH (P = 0.001 and P = 0.025, respectively). After surgery, 3D colour-encoded maps allowed for the visual recognition of the CSF volume changes in all patients. The amounts of ventricle volume loss of CH and NCH patients were not significantly different (P = 0.30), whereas readjustment of the sylvian fissure volume was conflicting in CH and NCH patients (P < 0.001). The Evans index correlated with ventricle volume in NCH patients. 3D mapping of CSF volume changes is feasible providing a quantitative follow-up of patients with hydrocephalus. (orig.)

  11. Changes in molar volume and heat capacity of actin upon polymerization. (United States)

    Quirion, F; Gicquaud, C


    We have used densimetry and microcalorimetry to measure the changes in molar volume and heat capacity of the actin molecule during Mg(2+)-induced polymerization. Molar volume is decreased by 720 ml/mol. This result is in contradiction with previous measurements by Ikkai and Ooi [(1966) Science 152, 1756-1757], and by Swezey and Somero [(1985) Biochemistry 24, 852-860]: both of these groups reported increases in actin volume during polymerization, of 391 ml/mol and 63 ml/mol respectively. We also observed a decrease in heat capacity of about 69.5 kJ.K-1.mol-1 during polymerization. This is in agreement with the concept of conformational fluctuation of proteins proposed by Lumry and Gregory [(1989) J.Mol. Liq. 42, 113-144]whereby either ligand binding by a protein or monomer-monomer interaction decreases the protein's conformational flexibility.

  12. Image analysis based quantification of bacterial volume change with high hydrostatic pressure. (United States)

    Pilavtepe-Celik, M; Balaban, M O; Alpas, H; Yousef, A E


    Scanning electron microscopy (SEM) images of Staphylococcus aureus 485 and Escherichia coli O157:H7 933 were taken after pressure treatments at 200 to 400 MPa. Software developed for this purpose was used to analyze SEM images and to calculate the change in view area and volume of cells. Significant increase in average cell view area and volume for S. aureus 485 was observed in response to pressure treatment at 400 MPa. Cell view area for E. coli O157:H7 933 significantly increased at 325 MPa, the maximum pressure treatment tested against this pathogen. In contrast to S. aureus, cells of E. coli O157:H7 exhibited significant increase in average view area and volume at 200 MPa. The pressure-induced increase in these parameters may be attributed to modifications in membrane properties, for example, denaturation of membrane-bound proteins and pressure-induced phase transition of membrane lipid bilayer.

  13. A pomegranate-inspired nanoscale design for large-volume-change lithium battery anodes (United States)

    Liu, Nian; Lu, Zhenda; Zhao, Jie; McDowell, Matthew T.; Lee, Hyun-Wook; Zhao, Wenting; Cui, Yi


    Silicon is an attractive material for anodes in energy storage devices, because it has ten times the theoretical capacity of its state-of-the-art carbonaceous counterpart. Silicon anodes can be used both in traditional lithium-ion batteries and in more recent Li-O2 and Li-S batteries as a replacement for the dendrite-forming lithium metal anodes. The main challenges associated with silicon anodes are structural degradation and instability of the solid-electrolyte interphase caused by the large volume change (~300%) during cycling, the occurrence of side reactions with the electrolyte, and the low volumetric capacity when the material size is reduced to a nanometre scale. Here, we propose a hierarchical structured silicon anode that tackles all three of these problems. Our design is inspired by the structure of a pomegranate, where single silicon nanoparticles are encapsulated by a conductive carbon layer that leaves enough room for expansion and contraction following lithiation and delithiation. An ensemble of these hybrid nanoparticles is then encapsulated by a thicker carbon layer in micrometre-size pouches to act as an electrolyte barrier. As a result of this hierarchical arrangement, the solid-electrolyte interphase remains stable and spatially confined, resulting in superior cyclability (97% capacity retention after 1,000 cycles). In addition, the microstructures lower the electrode-electrolyte contact area, resulting in high Coulombic efficiency (99.87%) and volumetric capacity (1,270 mAh cm-3), and the cycling remains stable even when the areal capacity is increased to the level of commercial lithium-ion batteries (3.7 mAh cm-2).

  14. Changes to Hospital Inpatient Volume After Newspaper Reporting of Medical Errors. (United States)

    Fukuda, Haruhisa


    The aim of this study was to investigate the influence of medical error case reporting by national newspapers on inpatient volume at acute care hospitals. A case-control study was conducted using the article databases of 3 major Japanese newspapers with nationwide circulation between fiscal years 2012 and 2013. Data on inpatient volume at acute care hospitals were obtained from a Japanese government survey between fiscal years 2011 and 2014. Panel data were constructed and analyzed using a difference-in-differences design. Acute care hospitals in Japan. Hospitals named in articles that included the terms "medical error" and "hospital" were designated case hospitals, which were matched with control hospitals using corresponding locations, nurse-to-patient ratios, and bed numbers. Medical error case reporting in newspapers. Changes to hospital inpatient volume after error reports. The sample comprised 40 case hospitals and 40 control hospitals. Difference-in-differences analyses indicated that newspaper reporting of medical errors was not significantly associated (P = 0.122) with overall inpatient volume. Medical error case reporting by newspapers showed no influence on inpatient volume. Hospitals therefore have little incentive to respond adequately and proactively to medical errors. There may be a need for government intervention to improve the posterror response and encourage better health care safety.


    NARCIS (Netherlands)

    UYAMA, T; Winter, Jobst B.; GROEN, Greetje; WILDEVUUR, Charles R.H.; MONDEN, Y; PROP, J


    Airway disease after lung or heart-lung transplantation is one of late major complications, affecting the prognosis of the transplants. Little is known about the causes of airway changes. We performed rat lung transplantation and investigated the late airway changes of the long-term surviving lung g

  16. Spanish Secondary School Students' Notions on the Causes and Consequences of Climate Change (United States)

    Punter, Pilar; Ochando-Pardo, Montserrat; Garcia, Javier


    This paper is part of an extensive study of secondary school students' preconceived ideas about climate change. Here, we undertake a survey in the province of Valencia (Spain) to ascertain secondary school students' notions of the causes and consequences of climate change. Results show, among other things, that students clearly relate the misuse…

  17. Large-scale geographical variation confirms that climate change causes birds to lay earlier

    NARCIS (Netherlands)

    Both, C; Artemyev, AV; Blaauw, B; Cowie, RJ; Dekhuijzen, AJ; Eeva, T; Enemar, A; Gustafsson, L; Ivankina, EV; Jarvinen, A; Metcalfe, NB; Nyholm, NEI; Potti, J; Ravussin, PA; Sanz, JJ; Silverin, B; Slater, FM; Sokolov, LV; Torok, J; Winkel, W; Wright, J; Zang, H; Visser, ME


    Advances in the phenology of organisms are often attributed to climate change, but alternatively, may reflect a publication bias towards advances and may be caused by environmental factors unrelated to climate change. Both factors are investigated using the breeding dates of 25 long-term studied

  18. Spanish Secondary School Students' Notions on the Causes and Consequences of Climate Change (United States)

    Punter, Pilar; Ochando-Pardo, Montserrat; Garcia, Javier


    This paper is part of an extensive study of secondary school students' preconceived ideas about climate change. Here, we undertake a survey in the province of Valencia (Spain) to ascertain secondary school students' notions of the causes and consequences of climate change. Results show, among other things, that students clearly relate the misuse…

  19. Cell volume regulation in cultured human retinal Muller cells is associated with changes in transmembrane potential.

    Directory of Open Access Journals (Sweden)

    Juan M Fernández

    Full Text Available Müller cells are mainly involved in controlling extracellular homeostasis in the retina, where intense neural activity alters ion concentrations and osmotic gradients, thus favoring cell swelling. This increase in cell volume is followed by a regulatory volume decrease response (RVD, which is known to be partially mediated by the activation of K(+ and anion channels. However, the precise mechanisms underlying osmotic swelling and subsequent cell volume regulation in Müller cells have been evaluated by only a few studies. Although the activation of ion channels during the RVD response may alter transmembrane potential (Vm, no studies have actually addressed this issue in Müller cells. The aim of the present work is to evaluate RVD using a retinal Müller cell line (MIO-M1 under different extracellular ionic conditions, and to study a possible association between RVD and changes in Vm. Cell volume and Vm changes were evaluated using fluorescent probe techniques and a mathematical model. Results show that cell swelling and subsequent RVD were accompanied by Vm depolarization followed by repolarization. This response depended on the composition of extracellular media. Cells exposed to a hypoosmotic solution with reduced ionic strength underwent maximum RVD and had a larger repolarization. Both of these responses were reduced by K(+ or Cl(- channel blockers. In contrast, cells facing a hypoosmotic solution with the same ionic strength as the isoosmotic solution showed a lower RVD and a smaller repolarization and were not affected by blockers. Together, experimental and simulated data led us to propose that the efficiency of the RVD process in Müller glia depends not only on the activation of ion channels, but is also strongly modulated by concurrent changes in the membrane potential. The relationship between ionic fluxes, changes in ion permeabilities and ion concentrations -all leading to changes in Vm- define the success of RVD.

  20. Know your tools - concordance of different methods for measuring brain volume change after ischemic stroke

    Energy Technology Data Exchange (ETDEWEB)

    Yassi, Nawaf; Campbell, Bruce C.V.; Davis, Stephen M.; Bivard, Andrew [The University of Melbourne, Departments of Medicine and Neurology, Melbourne Brain Centre rate at The Royal Melbourne Hospital, Parkville, Victoria (Australia); Moffat, Bradford A.; Steward, Christopher; Desmond, Patricia M. [The University of Melbourne, Department of Radiology, The Royal Melbourne Hospital, Parkville (Australia); Churilov, Leonid [The University of Melbourne, The Florey Institute of Neurosciences and Mental Health, Parkville (Australia); Parsons, Mark W. [University of Newcastle and Hunter Medical Research Institute, Priority Research Centre for Translational Neuroscience and Mental Health, Newcastle (Australia)


    Longitudinal brain volume changes have been investigated in a number of cerebral disorders as a surrogate marker of clinical outcome. In stroke, unique methodological challenges are posed by dynamic structural changes occurring after onset, particularly those relating to the infarct lesion. We aimed to evaluate agreement between different analysis methods for the measurement of post-stroke brain volume change, and to explore technical challenges inherent to these methods. Fifteen patients with anterior circulation stroke underwent magnetic resonance imaging within 1 week of onset and at 1 and 3 months. Whole-brain as well as grey- and white-matter volume were estimated separately using both an intensity-based and a surface watershed-based algorithm. In the case of the intensity-based algorithm, the analysis was also performed with and without exclusion of the infarct lesion. Due to the effects of peri-infarct edema at the baseline scan, longitudinal volume change was measured as percentage change between the 1 and 3-month scans. Intra-class and concordance correlation coefficients were used to assess agreement between the different analysis methods. Reduced major axis regression was used to inspect the nature of bias between measurements. Overall agreement between methods was modest with strong disagreement between some techniques. Measurements were variably impacted by procedures performed to account for infarct lesions. Improvements in volumetric methods and consensus between methodologies employed in different studies are necessary in order to increase the validity of conclusions derived from post-stroke cerebral volumetric studies. Readers should be aware of the potential impact of different methods on study conclusions. (orig.)

  1. Volume-of-change cone-beam CT for image-guided surgery (United States)

    Lee, Junghoon; Webster Stayman, J.; Otake, Yoshito; Schafer, Sebastian; Zbijewski, Wojciech; Khanna, A. Jay; Prince, Jerry L.; Siewerdsen, Jeffrey H.


    C-arm cone-beam CT (CBCT) can provide intraoperative 3D imaging capability for surgical guidance, but workflow and radiation dose are the significant barriers to broad utilization. One main reason is that each 3D image acquisition requires a complete scan with a full radiation dose to present a completely new 3D image every time. In this paper, we propose to utilize patient-specific CT or CBCT as prior knowledge to accurately reconstruct the aspects of the region that have changed by the surgical procedure from only a sparse set of x-rays. The proposed methods consist of a 3D-2D registration between the prior volume and a sparse set of intraoperative x-rays, creating digitally reconstructed radiographs (DRRs) from the registered prior volume, computing difference images by subtracting DRRs from the intraoperative x-rays, a penalized likelihood reconstruction of the volume of change (VOC) from the difference images, and finally a fusion of VOC reconstruction with the prior volume to visualize the entire surgical field. When the surgical changes are local and relatively small, the VOC reconstruction involves only a small volume size and a small number of projections, allowing less computation and lower radiation dose than is needed to reconstruct the entire surgical field. We applied this approach to sacroplasty phantom data obtained from a CBCT test bench and vertebroplasty data with a fresh cadaver acquired from a C-arm CBCT system with a flat-panel detector. The VOCs were reconstructed from a varying number of images (10-66 images) and compared to the CBCT ground truth using four different metrics (mean squared error, correlation coefficient, structural similarity index and perceptual difference model). The results show promising reconstruction quality with structural similarity to the ground truth close to 1 even when only 15-20 images were used, allowing dose reduction by the factor of 10-20.

  2. Micro-Computed Tomography of Tooth Volume Changes Following Post Removal. (United States)

    Kim, Jiyeon J; Alapati, Satish; Knoernschild, Kent L; Jeong, Yong-Hoon; Kim, Do Gyoon; Lee, Damian J


    To measure tooth volume change before and after post removal using micro-CT and to compare the difference among various combinations of prefabricated post and cement systems. Forty-eight extracted maxillary anterior teeth and mandibular canines were sectioned 13 mm from the apex. Root canals were properly instrumented. Preparations were filled with gutta percha using lateral condensation. Post space was prepared with a touch and heat device, leaving 5 mm of gutta percha from the apex. Specimens were scanned with micro-CT to establish objective baseline volume and divided into two groups of post systems: stainless steel (SS) ParaPost and glass-fiber reinforced composite (FRC) post. Half the posts for each group were cemented with Ketac Cem radiopaque glass-ionomer cement, and the other half with SpeedCEM dual-curing resin cement. The posts and residual cement were removed by the same operator, using the ultrasonic vibration technique under an endodontic operating microscope. The remaining tooth root structure was scanned again using micro-CT with volume reported (mm(3) ). The statistical difference between the combination of posts and cements was measured using the Kruskal-Wallis ANOVA test (α = 0.001). The independent variables were evaluated separately using post hoc Tukey examination to determine which groups resulted in a statistically significant difference. There was a statistical difference of tooth root volume change among the groups. Post hoc exam revealed a statistically significant difference in tooth root volume change between group 1 (SS + GI) and the other groups (α = 0.0002). Compared to other post and cement combinations, serrated parallel-sided SS posts cemented with GI cement had the most tooth root structure loss upon post removal using the ultrasonic vibration technique. © 2016 by the American College of Prosthodontists.

  3. Improving the clinical correlation of multiple sclerosis black hole volume change by paired-scan analysis. (United States)

    Tam, Roger C; Traboulsee, Anthony; Riddehough, Andrew; Li, David K B


    The change in T 1-hypointense lesion ("black hole") volume is an important marker of pathological progression in multiple sclerosis (MS). Black hole boundaries often have low contrast and are difficult to determine accurately and most (semi-)automated segmentation methods first compute the T 2-hyperintense lesions, which are a superset of the black holes and are typically more distinct, to form a search space for the T 1w lesions. Two main potential sources of measurement noise in longitudinal black hole volume computation are partial volume and variability in the T 2w lesion segmentation. A paired analysis approach is proposed herein that uses registration to equalize partial volume and lesion mask processing to combine T 2w lesion segmentations across time. The scans of 247 MS patients are used to compare a selected black hole computation method with an enhanced version incorporating paired analysis, using rank correlation to a clinical variable (MS functional composite) as the primary outcome measure. The comparison is done at nine different levels of intensity as a previous study suggests that darker black holes may yield stronger correlations. The results demonstrate that paired analysis can strongly improve longitudinal correlation (from -0.148 to -0.303 in this sample) and may produce segmentations that are more sensitive to clinically relevant changes.

  4. Coupled Structural, Thermal, Phase-Change and Electromagnetic Analysis for Superconductors. Volume 1 (United States)

    Felippa, C. A.; Farhat, C.; Park, K. C.; Militello, C.; Schuler, J. J.


    Described are the theoretical development and computer implementation of reliable and efficient methods for the analysis of coupled mechanical problems that involve the interaction of mechanical, thermal, phase-change and electromagnetic subproblems. The focus application has been the modeling of superconductivity and associated quantum-state phase-change phenomena. In support of this objective the work has addressed the following issues: (1) development of variational principles for finite elements, (2) finite element modeling of the electromagnetic problem, (3) coupling of thermal and mechanical effects, and (4) computer implementation and solution of the superconductivity transition problem. The main accomplishments have been: (1) the development of the theory of parametrized and gauged variational principles, (2) the application of those principled to the construction of electromagnetic, thermal and mechanical finite elements, and (3) the coupling of electromagnetic finite elements with thermal and superconducting effects, and (4) the first detailed finite element simulations of bulk superconductors, in particular the Meissner effect and the nature of the normal conducting boundary layer. The theoretical development is described in two volumes. This volume, Volume 1, describes mostly formulations for specific problems. Volume 2 describes generalization of those formulations.

  5. Double knockout of pendrin and Na-Cl cotransporter (NCC) causes severe salt wasting, volume depletion, and renal failure. (United States)

    Soleimani, Manoocher; Barone, Sharon; Xu, Jie; Shull, Gary E; Siddiqui, Faraz; Zahedi, Kamyar; Amlal, Hassane


    The Na-Cl cotransporter (NCC), which is the target of inhibition by thiazides, is located in close proximity to the chloride-absorbing transporter pendrin in the kidney distal nephron. Single deletion of pendrin or NCC does not cause salt wasting or excessive diuresis under basal conditions, raising the possibility that these transporters are predominantly active during salt depletion or in response to excess aldosterone. We hypothesized that pendrin and NCC compensate for loss of function of the other under basal conditions, thereby masking the role that each plays in salt absorption. To test our hypothesis, we generated pendrin/NCC double knockout (KO) mice by crossing pendrin KO mice with NCC KO mice. Pendrin/NCC double KO mice displayed severe salt wasting and sharp increase in urine output under basal conditions. As a result, animals developed profound volume depletion, renal failure, and metabolic alkalosis without hypokalemia, which were all corrected with salt replacement. We propose that the combined inhibition of pendrin and NCC can provide a strong diuretic regimen without causing hypokalemia for patients with fluid overload, including patients with congestive heart failure, nephrotic syndrome, diuretic resistance, or generalized edema.

  6. Survey data reflecting popular opinions of the causes and mitigation of climate change. (United States)

    Thompson, Jonathan E


    The data presented within this manuscript reports the results of a 20-question opinion survey concerning popular beliefs regarding the causes of and possible mitigation of climate change. The results and opinions from 746 survey respondents are presented. The data reflects certain misconceptions of climate change, and is useful for investigators to begin forming opinions of the public's knowledge regarding the potentially inflammatory topics of climate change, greenhouse gases, and geo-engineering.

  7. [Personality Change due to Brain Trauma Caused by Traffic Accidents and Its Assessment of Psychiatric Impairment]. (United States)

    Fan, Hui-yu; Zhang, Qin-ting; Tang, Tao; Cai, Wei-xiong


    To explore the main performance of personality change in people with mild psychiatric impairments which due to the brain trauma caused by traffic accidents and its value in assessment of psychiatric impairment. The condition of personality change of patients with traumatic brain injury caused by traffic accident was evaluated by the Scale of Personality Change Post-traumatic Brain Injury (SPCPTBI). Furthermore, the correlation between the personality change and the degrees of traumatic brain injury and psychiatric impairment were explored. Results In 271 samples, 239 (88.2%) with personality changes. Among these 239 samples, 178 (65.7%), 46 (17.0%), 15 (5.5%) with mild, moderate and severe personality changes, respectively. The ratio based on the extent of personality changes to the degree of brain trauma was not significant (P > 0.05), but the total score difference between the groups was significant (P traffic accident was high. Correlations exist between the personality change and the degree of psychiatric impairment. Personality change due to brain trauma caused by traffic accident can be assessed effectively by means of SPCPTBI, and the correlation between the total score and the extent of traumatic brain injury can be found.

  8. Stereological brain volume changes in post-weaned socially isolated rats

    DEFF Research Database (Denmark)

    Fabricius, Katrine; Helboe, Lone; Steiniger-Brach, Björn;


    have evaluated the neuroanatomical changes in this animal model in comparison to changes seen in schizophrenia. In this study, we applied stereological volume estimates to evaluate the total brain, the ventricular system, and the pyramidal and granular cell layers of the hippocampus in male and female...... Lister Hooded rats isolated from postnatal day 25 for 15 weeks. We observed the expected gender differences in total brain volume with males having larger brains than females. Further, we found that isolated males had significantly smaller brains than group-housed controls and larger lateral ventricles...... than controls. However, this was not seen in female rats. Isolated males had a significant smaller hippocampus, dentate gyrus and CA2/3 where isolated females had a significant smaller CA1 compared to controls. Thus, our results indicate that long-term isolation of male rats leads to neuroanatomical...

  9. Vanishing linear term in chemical potential difference in volume term of work of critical nucleus formation for phase transition without volume change

    CERN Document Server

    Mori, Atsushi


    A question is given on the form n({\\mu}_{\\beta}-{\\mu}_{\\alpha}) for the volume term of work of formation of critical nucleus. Here, n is the number of molecule undergone the phase transition, {\\mu} denotes the chemical potential, {\\alpha} and {\\beta} represent the parent and nucleating phases, respectively. In this paper we concentrate phase transition without volume change. We have calculated the volume term in terms of the chemical potential difference {\\mu}_{re}-{\\mu}_{eq}$ for this case. Here, {\\mu}_{re} is the chemical potential of the reservoir and {\\mu}_{eq} that at the phase transition. We have W_{vol} = -[({\\kappa}_{\\beta}-{\\kappa}_{\\alpha})/(2v_{eq}^2)] ({\\mu}_{re}-{\\mu}_{eq})^2 V_{\\beta} with {\\kappa} denoting the isothermal compressibility, v_{eq} being the molecular volume at the phase transition, V_{\\beta} the volume of the nucleus.

  10. Universal convergence of the specific volume changes of globular proteins upon unfolding. (United States)

    Schweiker, Katrina L; Fitz, Victoria W; Makhatadze, George I


    Both pressure and temperature are important environmental variables, and to obtain a complete understanding of the mechanisms of protein folding, it is necessary to determine how protein stability is dependent on these fundamental thermodynamic parameters. Although the temperature dependence of protein stability has been widely explored, the dependence of protein stability on pressure is not as well studied. In this paper, we report the results of the direct thermodynamic determination of the change in specific volume (DeltaV/V) upon protein unfolding, which defines the pressure dependence of protein stability, for five model proteins (ubiquitin, eglin c, ribonuclease A, lysozyme, and cytochrome c). We have shown that the specific volumetric changes upon unfolding for four of the proteins (ubiquitin, eglin c, ribonuclease A, and lysozyme) appear to converge to a common value at high temperatures. Analysis of various contributions to the change in volume upon protein unfolding allowed us to put forth the hypothesis that the change in volume due to hydration is very close to zero at this temperature, such that DeltaV/V is defined largely by the total volume of cavities and voids within a protein, and that this is a universal property of all small globular proteins without prosthetic groups. To test this hypothesis, additional experiments were performed with variants of eglin c that had site-directed substitutions at two buried positions, to create an additional cavity in the protein core. The results of these experiments, coupled with the structural analysis of cytochrome c showing a lower packing density compared to those of the other four proteins, provided further support for the hypothesis. Finally, we have shown that the deviation of the high-temperature DeltaV value of a given protein from the convergence value can be used to determine the size of the excess cavities in globular proteins.

  11. Experimental evidence that changes in mood cause changes in body dissatisfaction among undergraduate women. (United States)

    Haedt-Matt, Alissa A; Zalta, Alyson K; Forbush, Kelsie T; Keel, Pamela K


    Previous research has found concurrent and prospective associations between negative mood and body dissatisfaction; however, only experimental research can establish causal relationships. This study utilized an experimental design to examine the influence of negative mood on body dissatisfaction. Undergraduate women were randomly assigned to an experimental or control condition. Participants in the experimental condition (n=21) completed a negative mood induction procedure. Participants in the control condition (n=24) completed a neutral mood procedure. All participants completed visual analog scales regarding their mood and satisfaction with weight and shape before and after each manipulation. Body dissatisfaction increased following the procedure for experimental but not control participants, suggesting that negative mood caused increased body dissatisfaction. In cultures that idealize thinness, body dissatisfaction may arise from funneling general feelings of dysphoria into more concrete and culturally meaningful negative feelings about the body.

  12. Neonatal bilateral lidocaine administration into the ventral hippocampus caused postpubertal behavioral changes: An animal model of neurodevelopmental psychopathological disorders

    Directory of Open Access Journals (Sweden)

    Vanessa Blas-Valdivia


    Full Text Available Vanessa Blas-Valdivia, Edgar Cano-Europa, Adelaida Hernández-García, Rocio Ortiz-ButrónDepartamento de Fisiología “Mauricio Russek Berman”, Escuela Nacional de Ciencias Biológicas, I.P.N., Carpio y Plan de Ayala, MéxicoAbstract: Our aim was to investigate if neonatal bilateral administration of lidocaine into the ventral hippocampus would cause behavioral changes related to schizophrenia. A neonatal ventral-hippocampal lesion (nVH lesion was made with lidocaine in Wistar male pups. Two groups were formed, the first received lidocaine (4 μg/0.3 μL and the second an equal volume of vehicle. At day 35 and 56, both groups were tested for social contact, immobility caused by clamping the neck and dorsal immobility, locomotor activity in an open field, and tail flick (TF latency after a painful heat stimulus. All animals were then killed. Coronal cuts (7 μm of the brain were obtained and each brain section was stained with cresyl violet-eosin. The animals which received the nVH lesion with lidocaine had decreased social interaction at both ages. The rats with lesions, only at day 58 postnatal, increased their distance traveled and ambulatory time, with a decrease in their nonambulatory and reset time. The rats with lesions had a longer duration of immobility caused by clamping the neck and a longer dorsal immobility at both days 34 and 57 compared to control rats. The lidocaine-treated group spent less time to deflect the tail compared to the control group at postpubertal age. The neonatal bilateral administration of lidocaine into the ventral hippocampus caused some alterations, such as chromatin condensation, nucleolus loss, and cell shrinkage, but glial proliferation was not seen. Neonatal bilateral lidocaine administration into the ventral hippocampus caused postpubertal behavioral changes.Keywords: lidocaine, hippocampus, neonatal lesion, behavior, animal model, psychopathological disorders

  13. Accounting for uncertainty in volumes of seabed change measured with repeat multibeam sonar surveys (United States)

    Schimel, Alexandre C. G.; Ierodiaconou, Daniel; Hulands, Lachlan; Kennedy, David M.


    Seafloors of unconsolidated sediment are highly dynamic features; eroding or accumulating under the action of tides, waves and currents. Assessing which areas of the seafloor experienced change and measuring the corresponding volumes involved provide insights into these important active sedimentation processes. Computing the difference between Digital Elevation Models (DEMs) obtained from repeat Multibeam Echosounders (MBES) surveys has become a common technique to identify these areas, but the uncertainty in these datasets considerably affects the estimation of the volumes displaced. The two main techniques used to take into account uncertainty in volume estimations are the limitation of calculations to areas experiencing a change in depth beyond a chosen threshold, and the computation of volumetric confidence intervals. However, these techniques are still in their infancy and, as a result, are often crude, seldom used or poorly understood. In this article, we explored a number of possible methodological advances to address this issue, including: (1) using the uncertainty information provided by the MBES data processing algorithm CUBE, (2) adapting fluvial geomorphology techniques for volume calculations using spatially variable thresholds and (3) volumetric histograms. The nearshore seabed off Warrnambool harbour - located in the highly energetic southwest Victorian coast, Australia - was used as a test site. Four consecutive MBES surveys were carried out over a four-months period. The difference between consecutive DEMs revealed an area near the beach experiencing large sediment transfers - mostly erosion - and an area of reef experiencing increasing deposition from the advance of a nearby sediment sheet. The volumes of sediment displaced in these two areas were calculated using the techniques described above, both traditionally and using the suggested improvements. We compared the results and discussed the applicability of the new methodological improvements

  14. Brain gray matter volume changes associated with motor symptoms in patients with Parkinson's disease

    Institute of Scientific and Technical Information of China (English)

    Dezhi Kang; Fuyong Chen; Fangyu Wang; Guorong Wu; Ying Liu; Gang Wu; Lianghong Yu


    Background:Parkinson's disease (PD) is a common neurodegenerative disease.Most studies have found that the histopathological lesion is not only localized at the extrapyramidal area (basal ganglia) but also at the cortex in PD patients.Voxel-based morphometry (VBM) based on the voxel as a unit is described for quantitative detection of density and volume of brain tissue.In this study,VBM was used to investigate the brain gray matter changes associated with motor symptoms in PD patients.Methods:Twelve outpatients with PD and 12 healthy controls were recruited in our hospital from September 2013 to March 2014.VBM was performed on the whole brain of all subjects.Image processing and statistical analysis were performed using SPM8.A two-sample t test and multiple regression analysis were performed.Results were displayed with a threshold of P < 0.01,corrected by false discovery rate (FDR) correction and cluster size >30 voxels.Results:Comparing control healthy subjects with the patients,the data showed that PD patients had reduced gray matter volume in the postcentral gyrus,the right supramarginal center,superior temporal gyrus,precentral gyrus,Brodmann area 41,transverse temporal gyrus,Brodmann area 3,and inferior parietal Iobule.The data also found that between gray matter volume and UPDRSIII in PD patients,there were negative correlations in the right middle frontal gyrus,BA06,right precentral gyrus,right superior frontal gyrus,and medial frontal gyrus,and between gray matter volume and Hoehn-Yahr (HY) in PD patients,there were negative correlations in the right middle frontal gyrus,right superior frontal gyrus,BA6,and right precentral gyrus.Conclusions:These data supported that extensive changes associated with motor symptoms in the gray matter volume was mainly located in the related area of movement,which had obvious relevance with the progression of PD.

  15. Stress-induced changes in circadian rhythms of body temperature and activity in rats are not caused by pacemaker changes

    NARCIS (Netherlands)

    Meerlo, P; vandenHoofdakker, RH; Koolhaas, JM; Daan, S


    Previous work has shown that social stress in rats (i.e., defeat by an aggressive male conspecific) causes a variety of behavioral and physiological changes including alterations in the daily rhythms of body temperature and activity. To study the role of the circadian pacemaker in these

  16. Distance Based Root Cause Analysis and Change Impact Analysis of Performance Regressions

    Directory of Open Access Journals (Sweden)

    Junzan Zhou


    Full Text Available Performance regression testing is applied to uncover both performance and functional problems of software releases. A performance problem revealed by performance testing can be high response time, low throughput, or even being out of service. Mature performance testing process helps systematically detect software performance problems. However, it is difficult to identify the root cause and evaluate the potential change impact. In this paper, we present an approach leveraging server side logs for identifying root causes of performance problems. Firstly, server side logs are used to recover call tree of each business transaction. We define a novel distance based metric computed from call trees for root cause analysis and apply inverted index from methods to business transactions for change impact analysis. Empirical studies show that our approach can effectively and efficiently help developers diagnose root cause of performance problems.

  17. Hippocampal volume changes in healthy subjects at risk of unipolar depression

    DEFF Research Database (Denmark)

    Baaré, William F C; Vinberg, Maj; Knudsen, Gitte M


    Unipolar depression is moderately heritable. It is unclear whether structural brain changes associated with unipolar depression are present in healthy persons at risk of the disorder. Here we investigated whether a genetic predisposition to unipolar depression is associated with structural brain...... changes. A priori, hippocampal volume reductions were hypothesized. Using a high-risk study design, magnetic resonance imaging brain scans were obtained from 59 healthy high-risk subjects having a co-twin with unipolar depression, and 53 healthy low-risk subjects without a first-degree family history...

  18. Heteromeric Slick/Slack K+ channels show graded sensitivity to cell volume changes

    DEFF Research Database (Denmark)

    Tejada, Maria A; Hashem, Nadia; Callø, Kirstine


    Slick and Slack high-conductance K+ channels are found in the CNS, kidneys, pancreas, among other organs, where they play an important role in cell excitability as well as in ion transport processes. They are both activated by Na+ and Cl- but show a differential regulation by cell volume changes...... to osmotic challenges. In order to provide with the adequate water permeability to the cell membrane of Xenopus laevis oocytes, mRNA of aquaporin 1 was co-expressed with homomeric or heteromeric Slick and Slack α-subunits. Oocytes were superfused with hypotonic or hypertonic buffers and changes in currents...

  19. Future PMP Estimation in Korea under AR5 RCP 8.5 climate change scenarios and its Changes Cause Analysis (United States)

    Kim, S.; Lee, J.; Okjeong, L.; Bogyeong, C.; Park, M. W.


    In this presentation, Korea's probable maximum precipitations (PMPs) which reflects all of the storm data until recently are calculated, and are compared to the existing PMPs which were calculated at 2000. In Korea, abnormal weather phenomena such as typhoon Rusa and Maemi, and the extreme rainfall event occurred on the east coast of the northern region, that can have a significant impact on the PMP estimation, have frequently happened since 2000. After selecting 240 major storm events from 1973 to 2012, new PMPs are proposed with respect to storm areas (25, 100, 225, 400, 900, 2025, 4900, 10000 and 19600 km2) and storm durations (1, 2, 4, 6, 8, 12, 18, 24, 48 and 72 hours) using the Korea hydro-meteorological method. After estimating future PMPs using future rainfall and dew point temperature information under the Korea Meteorological Administration AR5 RCP 8.5, changes in the PMPs under climate change will be investigated by comparison with present and future PMPs. By separating the changes in PMPs under climate change into the changes caused by rainfall and dew point temperature, the relative impact of future rainfall and dew point temperature information under climate change on future PMPs is quantified. This research was supported by a grant 'Development of the Evaluation Technology for Complex Causes of Inundation Vulnerability and the Response Plans in Coastal Urban Areas for Adaptation to Climate Change' [MPSS-NH-2015-77] from the Natural Hazard Mitigation Research Group, Ministry of Public Safety and Security of Korea.

  20. Volume changes in Alzheimer's disease and mild cognitive impairment: cognitive associations

    Energy Technology Data Exchange (ETDEWEB)

    Evans, Matthew C.; Barnes, Josephine; Nielsen, Casper; Clegg, Shona L.; Blair, Melanie; Douiri, Abdel; Boyes, Richard G.; Fox, Nick C. [UCL Institute of Neurology, Dementia Research Centre, London (United Kingdom); Kim, Lois G. [UCL Institute of Neurology, Dementia Research Centre, London (United Kingdom); London School of Hygiene and Tropical Medicine, London (United Kingdom); Leung, Kelvin K.; Ourselin, Sebastien [UCL Institute of Neurology, Dementia Research Centre, London (United Kingdom); University College London, Centre for Medical Image Computing, London (United Kingdom)


    To assess the relationship between MRI-derived changes in whole-brain and ventricular volume with change in cognitive scores in Alzheimer's disease (AD), mild cognitive impairment (MCI) and control subjects. In total 131 control, 231 MCI and 99 AD subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort with T1-weighted volumetric MRIs from baseline and 12-month follow-up were used to derive volume changes. Mini mental state examination (MMSE), Alzheimer's disease assessment scale (ADAS)-cog and trails test changes were calculated over the same period. Brain atrophy rates and ventricular enlargement differed between subject groups (p < 0.0005) and in MCI and AD were associated with MMSE changes. Both measures were additionally associated with ADAS-cog and trails-B in MCI patients, and ventricular expansion was associated with ADAS-cog in AD patients. Brain atrophy (p < 0.0005) and ventricular expansion rates (p = 0.001) were higher in MCI subjects who progressed to AD within 12 months of follow-up compared with MCI subjects who remained stable. MCI subjects who progressed to AD within 12 months had similar atrophy rates to AD subjects. Whole-brain atrophy rates and ventricular enlargement differed between patient groups and healthy controls, and tracked disease progression and psychological decline, demonstrating their relevance as biomarkers. (orig.)

  1. Head posture and pharyngeal airway volume changes after bimaxillary surgery for mandibular prognathism. (United States)

    Kim, Min-Ah; Kim, Bo-Ram; Youn, Jong-Kuk; Kim, Yoon-Ji R; Park, Yang-Ho


    The purpose of this study was to evaluate head posture and the pharyngeal airway volume changes using 3D imaging after bimaxillary surgery in mandibular prognathism patients by null hypothesis. Cone-beam computed tomography (CBCT) scans were obtained for 25 mandibular prognathism patients before bimaxillary surgery (T1) and 6 months after surgery (T2). The head posture of each patient was assessed by measuring cranio-cervical angle on a midsagittal plane passing through the anterior nasal spine at T1 and T2. Additionally, the volume of each subject's pharyngeal airway was measured using InVivoDental 3D imaging software. The cranio-cervical angle increased significantly 6 months after bimaxillary surgery (p  0.05) at the same timepoints, while naso- and oro-pharyngeal airway volume decreased significantly (p Bimaxillary surgery resulted in significant head flexion and a slight decrease in total pharyngeal airway volume. Copyright © 2013 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  2. Variations in gastric compliance induced by acute blood volume changes in anesthetized rats

    Directory of Open Access Journals (Sweden)

    Graça J.R.V.


    Full Text Available The impact of acute volume imbalances on gastric volume (GV was studied in anesthetized rats (250-300 g. After cervical and femoral vessel cannulation, a balloon catheter was positioned in the proximal stomach. The opposite end of the catheter was connected to a barostat with an electronic sensor coupled to a plethysmometer. A standard ionic solution was used to fill the balloon (about 3.0 ml and the communicating vessel system, and to raise the reservoir liquid level 4 cm above the animals' xiphoid appendix. Due to constant barostat pressure, GV values were considered to represent the gastric compliance index. All animals were monitored for 90 min. After a basal interval, they were randomly assigned to normovolemic, hypervolemic, hypovolemic or restored protocols. Data were compared by ANOVA followed by Bonferroni's test. Mean arterial pressure (MAP, central venous pressure (CVP and GV values did not change in normovolemic animals (N = 5. Hypervolemic animals (N = 12 were transfused at 0.5 ml/min with a suspension of red blood cells in Ringer-lactate solution with albumin (12.5 ml/kg, which reduced GV values by 11.3% (P0.05. MAP and CVP values increased (P<0.05 after hypervolemia but decreased (P<0.05 with hypovolemia. In conclusion, blood volume level modulates gastric compliance, turning the stomach into an adjustable reservoir, which could be part of the homeostatic process to balance blood volume.

  3. CT-measured regional specific volume change reflects regional ventilation in supine sheep. (United States)

    Fuld, Matthew K; Easley, R Blaine; Saba, Osama I; Chon, Deokiee; Reinhardt, Joseph M; Hoffman, Eric A; Simon, Brett A


    Computer tomography (CT) imaging techniques permit the noninvasive measurement of regional lung function. Regional specific volume change (sVol), determined from the change in lung density over a tidal breath, should correlate with regional ventilation and regional lung expansion measured with other techniques. sVol was validated against xenon (Xe)-CT-specific ventilation (sV) in four anesthetized, intubated, mechanically ventilated sheep. Xe-CT used expiratory gated axial scanning during the washin and washout of 55% Xe. sVol was measured from the tidal changes in tissue density (H, houndsfield units) of lung regions using the relationship sVol = [1,000(Hi - He)]/[He(1,000 + Hi)], where He and Hi are expiratory and inspiratory regional density. Distinct anatomical markings were used to define corresponding lung regions of interest between inspiratory, expiratory, and Xe-CT images, with an average region of interest size of 1.6 +/- 0.7 ml. In addition, sVol was compared with regional volume changes measured directly from the positions of implanted metal markers in an additional animal. A linear relationship between sVol and sV was demonstrated over a wide range of regional sV found in the normal supine lung, with an overall correlation coefficient (R(2)) of 0.66. There was a tight correlation (R(2) = 0.97) between marker-measured volume changes and sVol. Regional sVol, which involves significantly reduced exposure to radiation and Xe gas compared with the Xe-CT method, represents a safe and efficient surrogate for measuring regional ventilation in experimental studies and patients.

  4. International conference on the role of the polar regions in global change: Proceedings. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Weller, G.; Wilson, C.L.; Severin, B.A.B. [eds.


    The International Conference on the Role of the Polar Regions in Global Change took place on the campus of the University of Alaska Fairbanks on June 11--15, 1990. The goal of the conference was to define and summarize the state of knowledge on the role of the polar regions in global change, and to identify gaps in knowledge. To this purpose experts in a wide variety of relevant disciplines were invited to present papers and hold panel discussions. While there are numerous conferences on global change, this conference dealt specifically with polar regions which occupy key positions in the global system. These two volumes of conference proceedings include papers on (1) detection and monitoring of change; (2) climate variability and climate forcing; (3) ocean, sea ice, and atmosphere interactions and processes; (4) effects on biota and biological feedbacks; (5) ice sheet, glacier and permafrost responses and feedbacks; (6) paleoenvironmental studies; and, (7) aerosols and trace gases.

  5. International conference on the role of the polar regions in global change: Proceedings. Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Weller, G.; Wilson, C.L.; Severin, B.A.B. [eds.


    The International Conference on the Role of the Polar Regions in Global Change took place on the campus of the University of Alaska Fairbanks on June 11--15, 1990. The goal of the conference was to define and summarize the state of knowledge on the role of the polar regions in global change, and to identify gaps in knowledge. To this purpose experts in a wide variety of relevant disciplines were invited to present papers and hold panel discussions. While there are numerous conferences on global change, this conference dealt specifically with the polar regions which occupy key positions in the global system. These two volumes of conference proceedings include papers on (1) detection and monitoring of change; (2) climate variability and climate forcing; (3) ocean, sea ice, and atmosphere interactions and processes; and (4) effects on biota and biological feedbacks; (5) ice sheet, glacier and permafrost responses and feedbacks, (6) paleoenvironmental studies; and, (7) aerosol and trace gases.

  6. The influence of peat volume change and vegetation on the hydrology of a kettle-hole wetland in Southern Ontario, Canada

    Directory of Open Access Journals (Sweden)

    P. Whittington


    Full Text Available Links between local hydrology and vegetation type exist in wetlands, yet it is unclear what role peat volume change plays in these interactions. We measured peat volume change and hydraulic conductivity (Kfield at three contrasting sites located on the quaking vegetation mat of a kettle-hole peatland in southern Ontario. The three sites had visibly different plant communities and were named, according to their dominant vegetation, Sedge (Carex spp., Typha (Typha angustifolia and Carr (Cornus stolonifera. Peat was also collected for laboratory studies of peat volume change, vertical (Kv and horizontal (Kh hydraulic conductivity and the effect of compression on hydraulic conductivity (Kc.In the field, the water table rose throughout the study period, resulting in swelling of the peat. Peat volume change above the -100 cm layer was 11.2%, 6.0% and 3.8% at the Sedge, Typha, and Carr sites respectively. In laboratory samples, a falling water table caused compression of the peat below the structured surface mat, and relative peat volume change between the sites followed the same pattern as in the field. Kfield, Kv and Kh generally decreased with depth from ca. 10-2 to 10-6 cm s-1. In the surface layers (0 to -50cm K trended Carr>Typha>Sedge, whereas the reverse trend was observed in deeper peat. Artificial compression affected K only in the uppermost layers (0 to -15cm. The decline in Kc with compression also trended Sedge>Typha>Carr. Differences in peat volume change and K are probably related to differences in vegetation and soil structure, and may be important for maintaining suitable growing conditions within each community.

  7. Changing meaning causes coupling changes within higher levels of the cortical hierarchy. (United States)

    Schofield, T M; Iverson, P; Kiebel, S J; Stephan, K E; Kilner, J M; Friston, K J; Crinion, J T; Price, C J; Leff, A P


    Processing of speech and nonspeech sounds occurs bilaterally within primary auditory cortex and surrounding regions of the superior temporal gyrus; however, the manner in which these regions interact during speech and nonspeech processing is not well understood. Here, we investigate the underlying neuronal architecture of the auditory system with magnetoencephalography and a mismatch paradigm. We used a spoken word as a repeating "standard" and periodically introduced 3 "oddball" stimuli that differed in the frequency spectrum of the word's vowel. The closest deviant was perceived as the same vowel as the standard, whereas the other 2 deviants were perceived as belonging to different vowel categories. The neuronal responses to these vowel stimuli were compared with responses elicited by perceptually matched tone stimuli under the same paradigm. For both speech and tones, deviant stimuli induced coupling changes within the same bilateral temporal lobe system. However, vowel oddball effects increased coupling within the left posterior superior temporal gyrus, whereas perceptually equivalent nonspeech oddball effects increased coupling within the right primary auditory cortex. Thus, we show a dissociation in neuronal interactions, occurring at both different hierarchal levels of the auditory system (superior temporal versus primary auditory cortex) and in different hemispheres (left versus right). This hierarchical specificity depends on whether auditory stimuli are embedded in a perceptual context (i.e., a word). Furthermore, our lateralization results suggest left hemisphere specificity for the processing of phonological stimuli, regardless of their elemental (i.e., spectrotemporal) characteristics.

  8. Coupled Structural, Thermal, Phase-change and Electromagnetic Analysis for Superconductors, Volume 2 (United States)

    Felippa, C. A.; Farhat, C.; Park, K. C.; Militello, C.; Schuler, J. J.


    Described are the theoretical development and computer implementation of reliable and efficient methods for the analysis of coupled mechanical problems that involve the interaction of mechanical, thermal, phase-change and electromag subproblems. The focus application has been the modeling of superconductivity and associated quantum-state phase change phenomena. In support of this objective the work has addressed the following issues: (1) development of variational principles for finite elements, (2) finite element modeling of the electromagnetic problem, (3) coupling of thermel and mechanical effects, and (4) computer implementation and solution of the superconductivity transition problem. The main accomplishments have been: (1) the development of the theory of parametrized and gauged variational principles, (2) the application of those principled to the construction of electromagnetic, thermal and mechanical finite elements, and (3) the coupling of electromagnetic finite elements with thermal and superconducting effects, and (4) the first detailed finite element simulations of bulk superconductors, in particular the Meissner effect and the nature of the normal conducting boundary layer. The theoretical development is described in two volumes. Volume 1 describes mostly formulation specific problems. Volume 2 describes generalization of those formulations.


    Aydin, Emsal; Karadag, Mert Ali; Cecen, Kursat; Cigsar, Gulsen; Aydin, Sergulen; Demir, Aslan; Bagcioglu, Murat; Tekdogan, Umit Yener


    We evaluated the association between the mean platelet volume (MPV) and monocyte/lymphocyte ratio (MLR) with brucella-caused epididymo-orchitis to determine if they could be used to differentiate between brucella and non-brucella epididymo-orchitis. The charts of 88 patients with non-brucella and 14 patients with brucella epididymo-orchitis were retrospectively reviewed. Brucellosis was diagnosed by isolating Brucella spp from a blood culture or from a serum agglutination titer ≥ 1:160 along with accompanying clinical findings. The patients with brucella epididymo-orchitis were significantly more likely to have a lower MPV and a higher MLR than those with non-brucella epididymo-orchitis. Using a MPV cut-off level of less than 9.25 fl to differentiate brucella from non-brucella epididymo-orchitis gives a sensitivity of 78.6%, a specifity of 78.4%, a positive predictive value of 36.7% and a negative predictive value of 95.8%. Using a MLR cut-off level of greater than 0.265 to differentiate brucella from non-brucella epididymo-orchitis gives a sensitivity of 71.4%, a specifity of 65.9%, a positive predictive value of 25% and a negative predictive value of 93.5.%. MPV and MLR values may assist in differentiating between brucella and non-brucella epididymo-orchitis.

  10. Glacier Volume Change Estimation Using Time Series of Improved Aster Dems (United States)

    Girod, Luc; Nuth, Christopher; Kääb, Andreas


    Volume change data is critical to the understanding of glacier response to climate change. The Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) system embarked on the Terra (EOS AM-1) satellite has been a unique source of systematic stereoscopic images covering the whole globe at 15m resolution and at a consistent quality for over 15 years. While satellite stereo sensors with significantly improved radiometric and spatial resolution are available to date, the potential of ASTER data lies in its long consistent time series that is unrivaled, though not fully exploited for change analysis due to lack of data accuracy and precision. Here, we developed an improved method for ASTER DEM generation and implemented it in the open source photogrammetric library and software suite MicMac. The method relies on the computation of a rational polynomial coefficients (RPC) model and the detection and correction of cross-track sensor jitter in order to compute DEMs. ASTER data are strongly affected by attitude jitter, mainly of approximately 4 km and 30 km wavelength, and improving the generation of ASTER DEMs requires removal of this effect. Our sensor modeling does not require ground control points and allows thus potentially for the automatic processing of large data volumes. As a proof of concept, we chose a set of glaciers with reference DEMs available to assess the quality of our measurements. We use time series of ASTER scenes from which we extracted DEMs with a ground sampling distance of 15m. Our method directly measures and accounts for the cross-track component of jitter so that the resulting DEMs are not contaminated by this process. Since the along-track component of jitter has the same direction as the stereo parallaxes, the two cannot be separated and the elevations extracted are thus contaminated by along-track jitter. Initial tests reveal no clear relation between the cross-track and along-track components so that the latter seems not to be

  11. Effect of Bcl-2 rs956572 polymorphism on age-related gray matter volume changes.

    Directory of Open Access Journals (Sweden)

    Mu-En Liu

    Full Text Available The anti-apoptotic protein B-cell CLL/lymphoma 2 (Bcl-2 gene is a major regulator of neural plasticity and cellular resilience. Recently, the Bcl-2 rs956572 single nucleotide polymorphism was proposed to be a functional allelic variant that modulates cellular vulnerability to apoptosis. Our cross-sectional study investigated the genetic effect of this Bcl-2 polymorphism on age-related decreases in gray matter (GM volume across the adult lifespan. Our sample comprised 330 healthy volunteers (191 male, 139 female with a mean age of 56.2±22.0 years (range: 21-92. Magnetic resonance imaging and genotyping of the Bcl-2 rs956572 were performed for each participant. The differences in regional GM volumes between G homozygotes and A-allele carriers were tested using optimized voxel-based morphometry. The association between the Bcl-2 rs956572 polymorphism and age was a predictor of regional GM volumes in the right cerebellum, bilateral lingual gyrus, right middle temporal gyrus, and right parahippocampal gyrus. We found that the volume of these five regions decreased with increasing age (all P<.001. Moreover, the downward slope was steeper among the Bcl-2 rs956572 A-allele carriers than in the G-homozygous participants. Our data provide convergent evidence for the genetic effect of the Bcl-2 functional allelic variant in brain aging. The rs956572 G-allele, which is associated with significantly higher Bcl-2 protein expression and diminished cellular sensitivity to stress-induced apoptosis, conferred a protective effect against age-related changes in brain GM volume, particularly in the cerebellum.

  12. Acute extracellular fluid volume changes increase ileocolonic resistance to saline flow in anesthetized dogs

    Directory of Open Access Journals (Sweden)

    Santiago Jr. A.T.


    Full Text Available We determined the effect of acute extracellular fluid volume changes on saline flow through 4 gut segments (ileocolonic, ileal, ileocolonic sphincter and proximal colon, perfused at constant pressure in anesthetized dogs. Two different experimental protocols were used: hypervolemia (iv saline infusion, 0.9% NaCl, 20 ml/min, volume up to 5% body weight and controlled hemorrhage (up to a 50% drop in mean arterial pressure. Mean ileocolonic flow (N = 6 was gradually and significantly decreased during the expansion (17.1%, P<0.05 and expanded (44.9%, P<0.05 periods while mean ileal flow (N = 7 was significantly decreased only during the expanded period (38%, P<0.05. Mean colonic flow (N = 7 was decreased during expansion (12%, P<0.05 but returned to control levels during the expanded period. Mean ileocolonic sphincter flow (N = 6 was not significantly modified. Mean ileocolonic flow (N = 10 was also decreased after hemorrhage (retracted period by 17% (P<0.05, but saline flow was not modified in the other separate circuits (N = 6, 5 and 4 for ileal, ileocolonic sphincter and colonic groups, respectively. The expansion effect was blocked by atropine (0.5 mg/kg, iv both on the ileocolonic (N = 6 and ileal (N = 5 circuits. Acute extracellular fluid volume retraction and expansion increased the lower gastrointestinal resistances to saline flow. These effects, which could physiologically decrease the liquid volume being supplied to the colon, are possible mechanisms activated to acutely balance liquid volume deficit and excess.

  13. No pituitary gland volume change in medication-free depressed patients. (United States)

    Eker, Cagdas; Ovali, Gulgun Yilmaz; Ozan, Erol; Eker, Ozlem Donat; Kitis, Omer; Coburn, Kerry; Gonul, Ali Saffet


    Increased serum cortisol levels and a hyperactive hypothalamo-pituitary-adrenal (HPA) axis have been proposed to play an important role in the pathophysiology of Major Depressive Disorder (MDD). However, there are inconsistent results regarding pituitary gland volume (PGV), which is one of the key elements of the HPA axis evaluated by MRI in depressed patients. In this study, we analyzed the PGV of medication-free moderately depressed MDD patients (N=34) and age and sex matched healthy controls (N=39). PGV did not differ between MDD patients and healthy controls [mean volume+/-S.D.; 0.76+/-0.17 cm3 and 0.75+/-0.14 cm3; ANCOVA, F1,69=1.25 p>0.05; respectively]. Our results confirm that volumetric PGV changes are not crucial for depression pathophysiology among unmedicated, moderately depressed adults.

  14. Numerical investigation of temporal changes in volcanic deformation caused by a gas slug ascent in the conduit (United States)

    Kawaguchi, Ryohei; Nishimura, Takeshi


    Strombolian type eruptions are considered to be generated by a sudden release of a large gas slug that migrates upward in the conduit filled with a low viscous basaltic magma. We examine volcano deformations caused by such a gas slug to understand the Strombolian eruption mechanism from geodetic observation data. We model spatio-temporal pressure changes in the conduit by using a gas slug ascent model presented by James et al. (2008). As a gas slug ascends in the conduit, its volume expands because of depressurization. Hence, the magma head lifts up in the conduit and the upper part of the conduit wall is stressed. In the conduit, magma pressure increases with depth according to the bulk density of magma: the gas slug part with a low density is characterized by a small pressure gradient, while the other parts, consisting of melt, are characterized by a large pressure gradient. We numerically calculate volcano deformations caused by the spatio-temporal changes of magma pressure predicted from the basic equations representing gas slug locations in the conduit. Simulation results show that the radial and vertical displacements and tilt changes indicate volcano deformations that represent the inflation originating from the stress increase at the upper part of conduit. As the gas slug reaches the shallow part of conduit, the rate of inflation observed in the radial displacement decreases, the vertical displacement starts to move downward, and the tilt turns to show down toward the crater. These deflation signals are caused by a moving deflation source in the conduit that is formed beneath the gas slug. Since these predicted features are not observed in the tilt records associated with explosions at Stromboli volcano (Genco and Ripepe, 2010), it is necessary to modify the gas slug ascent model or to introduce other mechanisms to better understand the magma dynamics of Strombolian eruption.

  15. Mean reticulocyte volume enhances the utility of red cell mean sphered cell volume in differentiating peripheral blood spherocytes of hereditary spherocytosis from other causes

    Directory of Open Access Journals (Sweden)

    Sukesh C Nair


    Full Text Available Context: Mean sphered cell volume (MSCV and mean reticulocyte volume (MRV are additional reticulocyte parameters generated while processing the blood samples on Beckman coulter LH 755 in the reticulocyte mode using the volume, conductivity and scatter technology. It has been observed that the difference between mean corpuscular volume (MCV and MSCV is higher in the cases of hereditary spherocytosis (HS and this difference is increasingly being utilized as a screening tool for spherocytes. In addition now there have been new observations that reticulocyte volume in cases of HS is less as compared to normal reticulocyte. Aims: Our aim was to test the usefulness of reticulocyte parameters like MSCV and MRV in distinguishing cases of HS and autoimmune hemolytic anemia (AIHA. Materials and Methods: This is a retrospective and partly prospective study where peripheral blood ethylenediaminetetraacetic acid samples from cases of HS (n = 57 and AIHA (n = 29 were processed on LH 755 in both the differential and the reticulocyte mode. The data generated were analyzed and compared with data from normal healthy donors (n = 46. Results: Using an algorithm of MCV - MSCV >10 and MRV - MSCV <25, a sensitivity of 84.2% and specificity of 94.7% was observed in cases of HS. Conclusions: With the reticulocyte analysis, we may now have a simple and cheap additional tool for screening of HS.

  16. [Pathomorphology of lung changes caused by gramoxone poisoning. Human pathologic and animal experimental studies]. (United States)

    Vadnay, I; Haraszti, A


    An account is given in this paper of changes caused by Gramoxone, a week killer, to the human lung as well as to experimental material. The process of damage was found to depend on the amount of toxic substance involved and on the route of uptake. Fibrosis, eventually, is the greatest danger. Intraperitoneal application leads to squamous epithelium metaplasia in the lung.

  17. Weight change and all-cause mortality in older adults: A meta-analysis (United States)

    This meta-analysis of observational cohort studies examined the association between weight change (weight loss, weight gain, and weight fluctuation) and all-cause mortality among older adults. We used PubMed (MEDLINE), Web of Science, and Cochrane Library to identify prospective studies published in...

  18. Dearomatized white spirit inhalation exposure causes long-lasting neurophysiological changes in rats

    DEFF Research Database (Denmark)

    Lund, S. P.; Simonsen, L.; Hass, Ulla


    Dearomatized white spirit inhalation exposure causes long-lasting neurophysioloical changes in rats. NEUROTOXICOL TERATOL 18(1), 67-76, 1996. -Exposure for 6 h per day, 5 days per week, during a period of 6 months to the organic solvent dearomatized white spirit (0, 400, and 800 ppm) was studied...

  19. Brain shrinkage in alcoholics is not caused by changes in hydration: a pathological study.


    Harper, C. G.; Kril, J J; Daly, J.M.


    Measurement of the water content of the cerebral white matter in 26 control and 24 alcoholic cases supports in vivo MRI studies and previous necropsy studies which appeared to show an increase in the water content in the alcoholic group. This negates the hypothesis that reversible brain shrinkage in alcoholics is caused by changes in the state of hydration.

  20. Initiation of resuscitation with high tidal volumes causes cerebral hemodynamic disturbance, brain inflammation and injury in preterm lambs.

    Directory of Open Access Journals (Sweden)

    Graeme R Polglase

    Full Text Available AIMS: Preterm infants can be inadvertently exposed to high tidal volumes (V(T in the delivery room, causing lung inflammation and injury, but little is known about their effects on the brain. The aim of this study was to compare an initial 15 min of high V(T resuscitation strategy to a less injurious resuscitation strategy on cerebral haemodynamics, inflammation and injury. METHODS: Preterm lambs at 126 d gestation were surgically instrumented prior to receiving resuscitation with either: 1 High V(T targeting 10-12 mL/kg for the first 15 min (n = 6 or 2 a protective resuscitation strategy (Prot V(T, consisting of prophylactic surfactant, a 20 s sustained inflation and a lower initial V(T (7 mL/kg; n = 6. Both groups were subsequently ventilated with a V(T 7 mL/kg. Blood gases, arterial pressures and carotid blood flows were recorded. Cerebral blood volume and oxygenation were assessed using near infrared spectroscopy. The brain was collected for biochemical and histologic assessment of inflammation, injury, vascular extravasation, hemorrhage and oxidative injury. Unventilated controls (UVC; n = 6 were used for comparison. RESULTS: High V(T lambs had worse oxygenation and required greater ventilatory support than Prot V(T lambs. High V(T resulted in cerebral haemodynamic instability during the initial 15 min, adverse cerebral tissue oxygenation index and cerebral vasoparalysis. While both resuscitation strategies increased lung and brain inflammation and oxidative stress, High V(T resuscitation significantly amplified the effect (p = 0.014 and p<0.001. Vascular extravasation was evident in the brains of 60% of High V(T lambs, but not in UVC or Prot V(T lambs. CONCLUSION: High V(T resulted in greater cerebral haemodynamic instability, increased brain inflammation, oxidative stress and vascular extravasation than a Prot V(T strategy. The initiation of resuscitation targeting Prot V(T may reduce the severity of brain injury in preterm neonates.

  1. Field Test Evaluation of Effect on Cone Resistance Caused by Change in Penetration Rate

    DEFF Research Database (Denmark)

    Poulsen, Rikke; Nielsen, Benjaminn Nordahl; Ibsen, Lars Bo


    This paper presents how a change in cone penetration rate affects the measured cone resistance during cone penetration testing in silty soils. Regardless of soil, type the standard rate of penetration is 20 mm/s and it is generally accepted that undrained penetration occurs in clay while drained...... in the laboratory. A change in the measured cone resistance occurs by lowering the penetration rate. This is caused by the changes in drainage conditions. Compared to the normal penetration rate of 20 mm/s, this paper illustrates that lowering the penetration rate leads to an increase in the cone resistance from 1...

  2. Large-scale geographical variation confirms that climate change causes birds to lay earlier. (United States)

    Both, Christiaan; Artemyev, Aleksandr V; Blaauw, Bert; Cowie, Richard J; Dekhuijzen, Aarnoud J; Eeva, Tapio; Enemar, Anders; Gustafsson, Lars; Ivankina, Elena V; Järvinen, Antero; Metcalfe, Neil B; Nyholm, N Erik I; Potti, Jaime; Ravussin, Pierre-Alain; Sanz, Juan Jose; Silverin, Bengt; Slater, Fred M; Sokolov, Leonid V; Török, János; Winkel, Wolfgang; Wright, Jonathan; Zang, Herwig; Visser, Marcel E


    Advances in the phenology of organisms are often attributed to climate change, but alternatively, may reflect a publication bias towards advances and may be caused by environmental factors unrelated to climate change. Both factors are investigated using the breeding dates of 25 long-term studied populations of Ficedula flycatchers across Europe. Trends in spring temperature varied markedly between study sites, and across populations the advancement of laying date was stronger in areas where the spring temperatures increased more, giving support to the theory that climate change causally affects breeding date advancement.

  3. Combination of volume and perfusion parameters reveals different types of grey matter changes in schizophrenia. (United States)

    Xu, Lixue; Qin, Wen; Zhuo, Chuanjun; Liu, Huaigui; Zhu, Jiajia; Yu, Chunshui


    Diverse brain structural and functional changes have been reported in schizophrenia. Identifying different types of brain changes may help to understand the neural mechanisms and to develop reliable biomarkers in schizophrenia. We aimed to categorize different grey matter changes in schizophrenia based on grey matter volume (GMV) and cerebral blood flow (CBF). Structural and perfusion magnetic resonance imaging data were acquired in 100 schizophrenia patients and 95 healthy comparison subjects. Voxel-based GMV comparison was used to show structural changes, CBF analysis was used to demonstrate functional changes. We identified three types of grey matter changes in schizophrenia: structural and functional impairments in the anterior cingulate cortex and insular cortex, displaying reduction in both GMV and CBF; structural impairment with preserved function in the frontal and temporal cortices, demonstrating decreased GMV with normal CBF; pure functional abnormality in the anterior cingulate cortex and lateral prefrontal cortex and putamen, showing altered CBF with normal GMV. By combination of GMV and CBF, we identified three types of grey matter changes in schizophrenia. These findings may help to understand the complex manifestations and to develop reliable biomarkers in schizophrenia.

  4. Changes in cause-specific mortality among the elderly in Canada, 1979–2011

    Directory of Open Access Journals (Sweden)

    Marie-Pier Bergeron-Boucher


    Full Text Available The structure of causes of death in Canada has been changing since the onset of the “cardiovascular revolution.” While mortality due to cardiovascular diseases has been declining, mortality due to other causes of death, such as cancers and Alzheimer’s disease has been increasing. Our research investigates how these changes have re-modeled life expectancy at age 65 and age 85, and what specific causes of death are involved. We distinguish between premature and senescent deaths in Canada, using a cause-specific age structure. Our results suggest that although a decline in premature deaths has contributed to increasing life expectancy in recent years, most of the gains in life expectancy at age 65 and 85 have resulted from a decline in senescent deaths. We also find a decline in mortality due to the main causes of death, leading to a greater diversification of causes. Depuis le début de la révolution cardiovasculaire, le Canada a connu d’importants changements dans la distribution des décès selon la cause. La mortalité par maladies cardiovasculaires a connu une importante diminution alors que les taux de mortalité pour les cancers et pour la maladie d’Alzheimer ont augmenté. Cet article examine comment ces changements ont influencé les tendances de l’espérance de vie à 65 et à 85 ans et quelles causes de décès spécifiques furent impliquées. Une distinction entre les décès prématurés et les décès liés à un processus de sénescence est réalisée, se basant sur deux indicateurs de variations par âge des causes de décès. Nos résultats suggèrent que la majorité des gains en espérance de vie à 65 et 85 ans proviennent d’une plus faible mortalité par cause de décès sénescente. De plus, une diminution des principales causes de décès chez les personnes âgées de 65 ans et plus laisse place à une plus grande diversification de causes aux grands âges.

  5. Influence of Environmental Factors on the Volume Change of Blended Cement Containing Steel Slag

    Institute of Scientific and Technical Information of China (English)


    In the condition of 20 ℃, 5% sulfate liquor curing, standard tap water curing and 50% RH curing-three different curing environments, the volume change of steel slag blended cement influenced by environmental factors was studied. With steel slag addition 10%, 30%, 50%, from 90 days to 356 days, the relationship of shrinkage and three different curing environments is: dry curing environment>tap water curing environment>sulfate curing environment. But, the sample shrinkage in 28 days has much difference with the curing environment, which has no obvious orderliness. The different effects on blended cement containing steel slag in different environmental factors were analyzed using SEM.

  6. Blood volume changes after radiotherapy of the CNS; Blutvolumenveraenderungen nach Strahlentherapie des zentralen Nervensystems

    Energy Technology Data Exchange (ETDEWEB)

    Wenz, F. [Radiologische Universitaetsklinik, Heidelberg (Germany); Fuss, M. [Radiologische Universitaetsklinik, Heidelberg (Germany); Scholdei, R. [Radiologische Universitaetsklinik, Heidelberg (Germany); Essig, M. [Abt. Onkologische Diagnostik und Therapie, Deutsches Krebsforschungszentrum, Heidelberg (Germany); Lohr, F. [Radiologische Universitaetsklinik, Heidelberg (Germany); Rempp, K. [Abt. Klinische Neuroradiologie, Univ. Heidelberg (Germany); Brix, G. [Abt. Biophysik und Medizinische Strahlenphysik, Deutsches Krebsforschungszentrum, Heidelberg (Germany); Knopp, M.V. [Abt. Onkologische Diagnostik und Therapie, Deutsches Krebsforschungszentrum, Heidelberg (Germany); Engenhart, R. [Radiologische Universitaetsklinik, Heidelberg (Germany); Wannenmacher, M. [Radiologische Universitaetsklinik, Heidelberg (Germany)


    The pathogenesis of late delayed radiation damage in normal brain tissue is most likely due to damage to the vascular endothelium. The mitotic activity of gliomas was shown to correlate with the tumor induced angiogenesis. Dynamic susceptibility contrast MR imaging (DSC MRI) allows the measurement of the cerebral hemodynamics based on the indicator dilution theory. We describe theory and technique of the method and present our experience with blood volume measurements after irradiation of the CNS. We established a double slice technique on a standard 1.5 T MR system without hardware modifications, which allows an absolute quantification of the blood volume in regions of interest (ROI) within the brain. Fifty-five T2* weighted double slice images were acquired before, during and after bolus injection of Gd-DTPA (0.1 mmol/kg in 5 sec.) using a SD FLASH sequence (simultaneous dual fast low angle shot, TR/TE1/TE2 31/16/25, flip angle 10 ). Concentration-time curves were calculated from the measured signal-time curves. Blood volume values in tissue were normalised and calculated in absolute values (ml/100 g) based on the knowledge of the arterial input function (AIF), which was measured in the brain supplying arteries. The whole procedure requires only 2 to 3 minutes, the time for post processing is about 15 to 20 minutes. Blood volume parameter images of representative cases demonstrate the blood volume changes after radiotherapy. A reduction in blood volume could be observed in normal brain tissue and low-grade gliomas, while recurrent tumors were accompanied by a local increase in blood volume. Radiation induced blood volume changes in the CNS can be measured using dynamic susceptibility contrast MR imaging. The measurements in normal brain tissue allow a functional in-vivo analysis of late delayed radiation reactions of the CNS. (orig.) [Deutsch] Die Pathogenese von Strahlenspaetfolgen am Gehirn wird auf eine Schaedigung der Gefaessendothelien zurueckgefuehrt. Die

  7. Collar Option Model for Managing the Cost Overrun Caused by Change Orders

    Directory of Open Access Journals (Sweden)

    Sanghyo Lee


    Full Text Available Effective change order management is very important in maintaining the financial sustainability of various stakeholders related to construction projects by minimizing cost overruns. In this study, we propose a zero-cost risk management approach based on the collar option model in order to control for the loss caused by change orders, the main cause of cost overruns in construction projects. We apply this model to actual projects for empirical analysis. The analysis, based on 237 projects, indicates that insurance buyers benefit from the collar option model in 46% of the cases, while insurance sellers do so in 53% of the cases. In most cases, the insurance buyer is the owner. According to the model, the owner experiences a loss when the cost overrun caused by change orders is lower than what was expected. In such cases, it is appropriate to conclude that the loss is not caused by the collar option model, but by the absence of additional revenue. However, the insurance seller suffers a loss if the cost overrun is higher than the strike price of the call option. Thus, the insurance seller needs to have expertise in construction management.


    Directory of Open Access Journals (Sweden)

    M. M. Khudobiak


    Full Text Available Background. According to preliminary results obtained, the development of hypoxemia caused by chest trauma affected lipid peroxidation stimulation leading to disruption of cell membranes structure and consequently cell death closing the ‘vicious’ circle, which in our opinion and according to the literature cause multiple organ failure. Objective. The aim of our study was to determine the features of morphological changes in cases of heart, lungs, liver injury after associated chest and both thighs trauma in rats. Methods. For histological examination the pieces of left ventricle tissues of heart, lungs and liver were used, which were fixed in 10% neutral formalin solution, dehydrated and embedded in paraffin blocks. Results. It was established that associated trauma of chest and both thighs in 1 day after the injury is accompanied by disturbances of hemodynamics in parenchymal organs due to venous congestion that occurs during the development of cardiovascular disease caused by traumatic shock. In the most severe period of maximum likelihood of complications, within 3 days, respiratory hypoxia, cardiovascular disorders, metabolic acidosis, and induced programmed cell death may develop. Conclusions. On the background of increasing pulmonary oedema (thickening of inter air sac membranes caused by associated trauma of chest and both thighs in rats after only one day of the experiment hemodynamic changes in heart (low-blood supply of vessels in epicardium and isolated blood vessels of venous type and liver (mainly plethora of blood vessels were observed, which lead to morphological changes of myocardium within 3 days.

  9. Secondary radiation damage as the main cause for unexpected volume effects : A histopathologic study of the parotid gland

    NARCIS (Netherlands)

    Konings, AWT; Faber, H; Cotteleer, F; Vissink, A; Coppes, RP


    Purpose: To elucidate with a histopathological study the mechanism of region-dependent volume effects in the partly irradiated parotid gland of the rat. Methods and Materials: Wistar rats were locally X-irradiated with collimators with conformal radiation portals for 100% volume and 50% cranial/caud

  10. Methotrexate causes a change in intestinal 5-hydroxytryptamine metabolism in rats. (United States)

    Takano, Yuho; Machida, Takuji; Obara, Yusuke; Hirano, Megumi; Kudo, Sae; Takagi, Minako; Hamaue, Naoya; Iizuka, Kenji; Hirafuji, Masahiko


    The effects of methotrexate on 5-hydroxytryptamine (5-HT) metabolism in the intestinal tissue of rats were investigated during the delayed phase after a single administration. Rats were i.p. injected with methotrexate or with saline as a control, and kaolin and food intakes were measured by an automatic monitoring apparatus. At 96 h after administration, dissected-out ileal tissue was frozen rapidly in liquid nitrogen for further analysis or fixed for immunohistochemical staining. Methotrexate at a dose of 50 mg/kg caused a time-dependent increase in kaolin intake lasting up to 72 h after administration, which returned to the control level at 96 h after administration. This dose of methotrexate caused a gradual decrease in body weight, food intake, and water intake lasting up to 72 h, which approached the control level at 96 h. Methotrexate caused pathologic changes, including a moderate inflammatory response in the ileal tissue and an increase in the number of L-tryptophan hydroxylase (TPH)-expressing cells in the ileal mucosa. Methotrexate also caused a significant increase in 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) content and in TPH1 mRNA expression in the ileal tissues. It had no significant effects on mRNA expression of serotonin transporter, COX-1, or COX-2 or on myeloperoxidase activity. This study demonstrated, for the first time, that methotrexate caused a change in the ileal 5-HT metabolism associated with hyperplasia of mucosal enterochromaffin cells.

  11. Separate and combined influence of posture and sprint running on plasma volume changes. (United States)

    Tsampoukos, Antonios; Stokes, Keith; Nevill, Mary


    It is currently unknown whether any changes in plasma volume (PV) after sprint running are inherent to sprint running per se or are due to other confounding factors such as changes in posture. The purpose of the present study was to examine the independent effects of sprint running on PV changes. Eight females completed two trials on separate days: (1) a 30-s sprint on a non-motorised treadmill and (2) a control trial where no exercise was undertaken but blood samples were taken at identical time points as in the exercise trial. Changes in PV were calculated using haematocrit and haemoglobin. Post-sprint PV reductions were greater in the sprint than the control trial (mean: -17.7, SD=3.1% vs. mean: -7.5, s = 4.9, Psprint than the control trial in most sampling points. These data show that sprint running of only 30 s induces transient reductions in PV independently of posture change. The present findings suggest that PV changes due to sprint running should be routinely reported as well as the posture and the exact time in this posture.

  12. The causes of the resistance against changes by the teachers in schools

    Directory of Open Access Journals (Sweden)

    Gizem Gürses


    Full Text Available This study aims to determine the causes of the resistance to changes by the teachers who work at state schools which are affiliated to the Province of Izmir of Education. Moreover, it is wished to set if the point of views differs according to the changes of gender and seniority of participants. The model of this study is survey and it is descriptive study. The population of this study consists of 18770 teachers who work in 796 primary schools in Izmir, districts and villages of Izmir during 2009-2010 education periods. The sample of this study consists of 750 teachers who work in 96 primary schools in city center, districts and villages in Izmir. In the reasons of the resistance to changes in elementary schools, research findings show that the resistance reason is “moderate” and this is caused by the teachers’ lack of knowledge about the process of change and unwillingness to get new duties, roles and responsibilities. In addition, the research indicates that the resistance is “high” when it is related to the organizational characteristics of the school and the resistance level is “low” when it is related to the fear of suffering from the change and the schools administrators’ inability to manage the change.

  13. Observing Sea Level Change and its Causes with Satellite Remote Sensing (United States)

    Boening, Carmen; Fu, Lee-Lueng; Landerer, Felix; Willis, Josh


    Sea level rise as a response to a changing climate is an imminent threat for coastal communities in the near future. Coastal zone management relies on most accurate predictions of sea level change over the coming decades for planning potential mitigation efforts. Hence, it is of high importance to accurately measure changes and understand physical processes behind them in great detail on a variety of time scales. Satellite observations of sea level height from altimetry have provided an unprecedented understanding of global changes and regional patterns for over two decades. With more and more missions providing now also observations of causes such as water mass changes due to ice melt and land hydrology as well as the ocean heat and salinity budget and local and regional wind patterns, we can now get a comprehensive understanding of the physical processes causing the short to long term changes in sea level. Here, we present an overview of sea level observations in combination with a suite of measurements looking at sea level contributions to provide insight into current and future challenges to understand the sea level budget and its impact on the accuracy of future projections.

  14. Pathways of deep cyclones associated with large volume changes (LVCs) and major Baltic inflows (MBIs) (United States)

    Lehmann, Andreas; Höflich, Katharina; Post, Piia; Myrberg, Kai


    Large volume changes (LVCs) and major Baltic inflows (MBIs) are essential processes for the water exchange and renewal of the stagnant water in the Baltic Sea deep basins. These strong inflows are known to be forced by persistent westerly wind conditions. In this study, MBIs are considered as subset of LVCs transporting with the large water volume a big amount of highly saline and oxygenated water into the Baltic Sea. Since the early 1980s the frequency of MBIs has dropped drastically from 5 to 7 events to only one inflow per decade, and long lasting periods without MBIs became the usual state. Only in January 1993, 2003 and December 2014 MBIs occurred that were able to interrupt the stagnation periods in the deep basins of the Baltic Sea. However, in spite of the decreasing frequency of MBIs, there is no obvious decrease of LVCs. The Landsort sea level is known to reflect the mean sea level of the Baltic Sea very well, and hence LVCs have been calculated for the period 1887-2015 filtering daily time series of Landsort sea surface elevation anomalies. The cases with local minimum and maximum difference resulting in at least 60 km3 of water volume change excluding the volume change due to runoff have been chosen for a closer study (1948-2013) of characteristic pathways of deep cyclones. The average duration of LVCs is about 40 days. During this time, 5-6 deep cyclones move along characteristic storm tracks. Furthermore, MBIs are characterized by even higher cyclonic activity compared to average LVCs. We obtained four main routes of deep cyclones which were associated with LVCs, but also with the climatology. One is approaching from the west at about 56-60°N, passing the northern North Sea, northern Denmark, Sweden and the Island of Gotland. A second broad corridor of frequent cyclone pathways enters the study area north of Scotland between 60 and 66°N turning north-eastwards along the northern coast of Scandinavia. This branch bifurcates into smaller routes. One

  15. Changes in gray matter volume after microsurgical lumbar discectomy: A longitudinal analysis

    Directory of Open Access Journals (Sweden)

    Michael eLuchtmann


    Full Text Available People around the world suffer chronic lower back pain. Because spine imaging often does not explain the degree of perceived pain reported by patients, the role of the processing of nociceptor signals in the brain as the basis of pain perception is gaining increased attention. Modern neuroimaging techniques (including functional and morphometric methods have produced results that suggest which brain areas may play a crucial role in the perception of acute and chronic pain. In this study, we examined twelve patients with chronic low back pain and sciatica, both resulting from lumbar disc herniation. Structural magnetic resonance imaging (MRI of the brain was performed one day prior to and about four weeks after microsurgical lumbar discectomy. The subsequent MRI revealed an increase in gray matter volume in the basal ganglia but a decrease in volume in the hippocampus, which suggests the complexity of the network that involves movement, pain processing, and aspects of memory. Interestingly, volume changes in the hippocampus were significantly correlated to preoperative pain intensity but not to the duration of chronic pain. Mapping structural changes of the brain that result from lumbar disc herniation has the potential to enhance our understanding of the neuropathology of chronic low back pain and sciatica and therefore may help to optimize the decisions we make about conservative and surgical treatments in the future. The possibility of illuminating more of the details of central pain processing in lumbar disc herniation, as well as the accompanying personal and economic impact of pain relief worldwide, calls for future large-scale clinical studies.

  16. Attributing causes of regional climate change in the Baltic Sea area (United States)

    Bhend, Jonas; Gaillard-Lemdahl, Marie-José; Hansson, Hans-Christen


    Here we assess to what extent the effect of forcing mechanisms on the observed climate change in the Baltic Sea area can be detected. In particular, we assess the effect of factors causing large-scale warming (mainly anthropogenic greenhouse gases) and the regional effect of atmospheric aerosols and land-cover and land-use changes. Unfortunately, only very few targeted analyses for the Baltic catchment area are available at the moment, but findings at the regional scale are generally qualitatively consistent with global or hemispheric analyses. The observed warming in summer cannot be explained without human influence (in particular the warming effect of increasing atmospheric greenhouse gas concentrations). In other seasons and for other aspects of regional warming, findings are mixed or not significant as of yet. In addition, large-scale circulation and rainfall changes in the northern hemisphere and the Arctic have been detected to exceed natural internal variability. Other aspects of regional climate change including changes in storminess, snow properties, runoff and the changing physical properties of the Baltic Sea have not been formally attributed to human influence yet. Scientific understanding of the effect of aerosols on regional climate is still accumulating. It is likely that the major emission changes in Europe have had an effect on the climate in the Baltic region, the magnitude of which, however, is still unknown. Development of the modelling capability and targeted analyses are urgently needed to reduce the uncertainties related to the effect of aerosol changes on regional observed climate change. Historic deforestation and recent reforestation are the major anthropogenic land-cover changes affecting the Baltic Sea area. From all studies at hand it can be concluded that there is no evidence that anthropogenic land-cover change would be one of the forcings behind the recent warming in the Baltic region. However, past anthropogenic land-cover change

  17. Changes in perceived recovery status scale following high-volume muscle damaging resistance exercise. (United States)

    Sikorski, Eric M; Wilson, Jacob M; Lowery, Ryan P; Joy, Jordan M; Laurent, C Matthew; Wilson, Stephanie M-C; Hesson, Domini; Naimo, Marshall A; Averbuch, Brian; Gilchrist, Phil


    Currently no research has investigated the relationship between muscle damage, hormonal status, and perceived recovery scale (PRS). Therefore, the purpose of this study was to determine the effects of a high-volume training session on PRS and to determine the relationship between levels of testosterone, cortisol, and creatine kinase (CK) and PRS. Thirty-five trained subjects (21.3 ± 1.9 years) were recruited. All subjects participated in a high-volume resistance training session consisting of 3 sets of full squats, bench press, deadlifts, pullups, dips, bent over rows, shoulder press, and barbell curls and extensions. Pre-PRS and post-PRS measurements (0-10), soreness, CK, cortisol, and testosterone were measured before and 48 hours after training. Perceived recovery scale declined from 8.6 ± 2.3 to 4.2 ± 1.85 (p Creatine kinase significantly increased from pre- to postworkout (189.4 ± 100.2 to 512 ± 222.7 U/L). Cortisol, testosterone, and free testosterone did not change. There was an inverse relationship between CK and PRS (r = 0.58, p resistance exercise lowers PRS scores. These changes are partly explained by a rise in serum indices of muscle damage. Moreover, free testosterone seems to have a positive relationship with PRS.

  18. Simulating Longitudinal Brain MRIs with Known Volume Changes and Realistic Variations in Image Intensity. (United States)

    Khanal, Bishesh; Ayache, Nicholas; Pennec, Xavier


    This paper presents a simulator tool that can simulate large databases of visually realistic longitudinal MRIs with known volume changes. The simulator is based on a previously proposed biophysical model of brain deformation due to atrophy in AD. In this work, we propose a novel way of reproducing realistic intensity variation in longitudinal brain MRIs, which is inspired by an approach used for the generation of synthetic cardiac sequence images. This approach combines a deformation field obtained from the biophysical model with a deformation field obtained by a non-rigid registration of two images. The combined deformation field is then used to simulate a new image with specified atrophy from the first image, but with the intensity characteristics of the second image. This allows to generate the realistic variations present in real longitudinal time-series of images, such as the independence of noise between two acquisitions and the potential presence of variable acquisition artifacts. Various options available in the simulator software are briefly explained in this paper. In addition, the software is released as an open-source repository. The availability of the software allows researchers to produce tailored databases of images with ground truth volume changes; we believe this will help developing more robust brain morphometry tools. Additionally, we believe that the scientific community can also use the software to further experiment with the proposed model, and add more complex models of brain deformation and atrophy generation.

  19. Intermediate-depth earthquake faulting by dehydration embrittlement with negative volume change (United States)

    Jung, Haemyeong; Green, Harry W., II; Dobrzhinetskaya, Larissa F.


    Earthquakes are observed to occur in subduction zones to depths of approximately 680km, even though unassisted brittle failure is inhibited at depths greater than about 50km, owing to the high pressures and temperatures. It is thought that such earthquakes (particularly those at intermediate depths of 50-300km) may instead be triggered by embrittlement accompanying dehydration of hydrous minerals, principally serpentine. A problem with failure by serpentine dehydration is that the volume change accompanying dehydration becomes negative at pressures of 2-4GPa (60-120km depth), above which brittle fracture mechanics predicts that the instability should be quenched. Here we show that dehydration of antigorite serpentinite under stress results in faults delineated by ultrafine-grained solid reaction products formed during dehydration. This phenomenon was observed under all conditions tested (pressures of 1-6GPa temperatures of 650-820°C), independent of the sign of the volume change of reaction. Although this result contradicts expectations from fracture mechanics, it can be explained by separation of fluid from solid residue before and during faulting, a hypothesis supported by our observations. These observations confirm that dehydration embrittlement is a viable mechanism for nucleating earthquakes independent of depth, as long as there are hydrous minerals breaking down under a differential stress.

  20. Midlife obesity and trajectories of brain volume changes in older adults. (United States)

    Driscoll, Ira; Beydoun, May A; An, Yang; Davatzikos, Christos; Ferrucci, Luigi; Zonderman, Alan B; Resnick, Susan M


    Although obesity has been linked to structural brain changes, little is known about its associations with the rates of brain atrophy. We examined associations between global (BMI) and central (waist circumference) midlife obesity and subsequent trajectories of regional brain atrophy in 152 individuals [M (age) = 69 ± 7.8] prospectively followed through the Baltimore Longitudinal Study of Aging; 21 individuals became impaired during follow-up. We report no associations (P > 0.05) between either global or central midlife obesity and subsequent rates of regional brain volume changes against a background of age-related atrophy in older individuals who remained nondemented. When looking at the entire sample, greater decline was observed in the volume of gray matter, precuneus, cingulate and orbito-frontal gyri for globally obese (P obesity, a different pattern of results emerged. Overall, our results suggest that midlife obesity may be an important modifier of brain atrophy in individuals who are developing cognitive impairment and dementia, while it has little effect on structural brain integrity in nondemented older adults. Moreover, the discrepancies in findings between studies may be in part due to participant sampling and methodological differences. Published 2011 Wiley Periodicals, Inc.

  1. Entropy and volume change of dissociation in tobacco mosaic virus probed by high pressure. (United States)

    Bispo, Jose A C; Bonafe, Carlos F S; Joekes, Ines; Martinez, Ernesto A; Carvalho, Giovani B M; Norberto, Douglas R


    Virus dissociation and inactivation by high pressure have been extensively studied in recent decades. Pressure-induced dissociation of viral particles involves a reduction in the Gibbs free energy of dissociation and a negative change in volume. In this work, we investigated the combined effect of high pressure and temperature on the dissociation of tobacco mosaic virus (TMV). We assumed the presence of two states of TMV with different tendencies to dissociate. Thus one form presents a low tendency (L) and the other a high tendency (H) to dissociate. Based on the model described here, the L-H transition was favored by an increase in pressure and a decrease in temperature. The volume change of dissociation was pressure- and temperature-dependent, with a highly negative value of -80 mL/mol being recorded at 0 °C and atmospheric pressure. The entropy and enthalpy of dissociation were very temperature- and pressure-dependent, with values of entropy of 450 to -1300 kJ/mol and values of enthalpy of 5.5 × 10(4) to 2.4 × 10(4) kJ/mol. The dissociation of TMV was enthalpy-driven at all temperatures and pressures investigated. Based on these findings, we conclude that the model presented allows accurate predictions of viral dissociation behavior in different experimental conditions.

  2. A quantitative analysis of the causes of the global climate change research distribution

    DEFF Research Database (Denmark)

    Pasgaard, Maya; Strange, Niels


    investigates whether the need for knowledge on climate changes in the most vulnerable regions of the world is met by the supply of knowledge measured by scientific research publications from the last decade. A quantitative analysis of more than 15,000 scientific publications from 197 countries investigates...... the distribution of climate change research and the potential causes of this distribution. More than 13 explanatory variables representing vulnerability, geographical, demographical, economical and institutional indicators are included in the analysis. The results show that the supply of climate change knowledge...... is biased toward richer countries, which are more stable and less corrupt, have higher school enrolment and expenditures on research and development, emit more carbon and are less vulnerable to climate change. Similarly, the production of knowledge, analyzed by author affiliations, is skewed away from...

  3. [Mortality by cause. The trends demand changes in the health system]. (United States)

    Cardenas Elizalde, R; Fernandez Ham, P


    Three significant recent trends in Mexican mortality are the decline in deaths due to large groups of causes, the increasing proportion of deaths due to nontransmissible causes, and the convergence of state mortality rates. The World Bank has proposed a classification of causes of death into three large groups according to the type of intervention required to reduce them: transmissible, maternal, and perinatal; nontransmissible; and accidents and injuries. The first group concentrates disorders susceptible to reduction with low cost and highly effective interventions such as vaccines and sanitary measures, generally available at the primary level of care. The nontransmissible disorders include chronic degenerative diseases requiring more expensive and prolonged treatment corresponding to the second and third levels of care and implying lifestyle changes. Injuries and accidents are potentially preventable through specific programs of the health system. The proportion of Mexican deaths due to nontransmissible causes increased from 53.4% in 1979 to 67.8% in 1992. Five of the ten main causes of death are nontransmissible: heart disease, malignant tumors, cerebrovascular diseases, cirrhosis, and diabetes mellitus. The increased proportion of deaths due to nontransmissible diseases is a consequence of the rapid decline in deaths from transmissible causes. Deaths due to transmissible causes declined by 47.5% between 1979 and 1992. Increased educational levels, potable water and sewage services, increased vaccination coverage and similar interventions contributed to mortality decline in the least developed regions. The greatest mortality gains were in the areas with the highest initial rates, which helped to homogenize state mortality rates. Among transmissible diseases, diarrhea and pneumonia and influenza dropped from first and second to tenth and eighth place, respectively. In 1992, only Chiapas and Oaxaca maintained mortality rates significantly higher than the rest of

  4. Changes in the Leading Cause of Death: Recent Patterns in Heart Disease and Cancer Mortality. (United States)

    Heron, Melonie; Anderson, Robert N


    Data from the National Vital Statistics System •Heart disease has consistently been the leading cause of death in the United States and remained so in 2014. •The gap between the number of heart disease and cancer deaths generally widened from 1950 through 1968, narrowed from 1968 through 2012, and then slightly widened again from 2012 through 2014. •The mortality burden of cancer has surpassed that of heart disease in several states. In 2000, there were only 2 states where cancer was the leading cause of death; in 2014, there were 22. •Heart disease remained the leading cause of death for the non-Hispanic white and non-Hispanic black populations in 2014. •Cancer is now the leading cause of death for the non-Hispanic Asian or Pacific Islander and Hispanic populations. The timing of the leading-cause crossover varied by group. For the total U.S. population, heart disease has been the leading cause of death for decades, with cancer the second leading cause (1). However, the ranking of these causes has varied across demographic group and geographic unit over time. Rankings are based on the number of deaths and reflect mortality burden rather than risk of death (2). This report highlights changes in the mortality burden of heart disease and cancer and presents findings by state, race, and Hispanic origin. All material appearing in this report is in the public domain and may be reproduced or copied without permission; citation as to source, however, is appreciated.

  5. Between information systems and physical structure of the city: New causes of climate changes

    Directory of Open Access Journals (Sweden)

    Mihajlov Vladimir


    Full Text Available Because of the frequent and significant spatial transformations, an increasing climate change regime in urban areas occurs. In this paper a comprehensive reflection on these changes is analyzed, concerning one of the major causes - the social transformation and the growing use of information, networks and technology, used by city dwellers in everyday life. Advanced communications and the Internet provide urban concentration and decentralization, creating new spatial and geographic network, with a new allocation of space, for manufacturing and services. The consequence may be recognized in increasing individualization and social habits of city dwellers, as well as in modified way of households use, changing neighbourhoods and public spaces, transport systems, as the final outcome is the climate change. In this paper, the interdependence between information networks is emphasized - between virtual and physical environment, as well as changes in the way of life of the city, which ultimately lead to a new trigger for climate change. Users have never been more mobile in the physical space (commuting and tourist travel, while in the virtual space they are associated with the fixed points - everybody can be located, by using email or social network. Unexpectedly, the cause of the problem which is considered in this paper, is increased mobility in the real space, while city dwellers remain in one place, by using their virtual electronic connections. Thus, the role of city dwellers in creating climate change depends upon their spatial distribution and relationship towards information's and network activity. As a result, the drivers in city development are recognized on network nodes. Current crises in the global environment (economic, climate and social indicate the need to develop multi-functional environment and a greater appreciation of natural factors. Therefore, as a decisive factor for the adaptation of urban structure on climate change is the

  6. Three Decades of Volume Change of a Small Greenlandic Glacier Using Ground Penetrating Radar, Structure from Motion, and Aerial Photogrammetry

    DEFF Research Database (Denmark)

    Marcer, M.; Stentoft, Peter Alexander; Bjerre, Elisa


    Glaciers in the Arctic are losing mass at an increasing rate. Here we use surface topography derived from Structure from Motion (SfM) and ice volume from ground penetrating radar (GPR) to describe the 2014 state of Aqqutikitsoq glacier (2.85 km) on Greenland's west coast. A photogrammetrically...... topography, the approach constitutes a viable alternative where the use of drones is not possible. Our investigations constitute the first glacier on Greenland's west coast where ice volume was determined and volume change calculated. The glacier's thinning rate is comparable to, for example, the Swiss Alps...... and underlines that arctic glaciers are subject to fast changes....

  7. Changes in plasma volume during bed rest - Effects of menstrual cycle and estrogen administration (United States)

    Fortney, S. M.; Beckett, W. S.; Carpenter, A. J.; Davis, J.; Drew, H.


    The effect of increased blood estrogen concentration, caused either during normal menstrual cycles or by exogenous administration of premarin, on the bed-rest (BR) induced decrease in plasma volume (PV) was investigated. In women who underwent duplicate 11-day BR without estrogen supplementation, the PV was found to decrease significantly, during the first 5 days of BR, to a lower level at which it remained for the rest of the BR period. In women who began BR in the periovulatory stage of the menstrual cycle, the loss of PV was delayed, while women who began BR during other stages of the cycle exhibited the usual trend of the PV decrease during the BR. In women who underwent a single 12-day BR period while taking premarin (1.25 mg/day), PV was found to decrease during the first 4-5 days of BR, but then returned toward the pre-BR level during the remainder of the BR, indicating that estrogens have a role in stabilizing body fluid volume.

  8. You save money when you buy in bulk: does volume-based pricing cause people to buy more beer? (United States)

    Bray, Jeremy W; Loomis, Brett R; Engelen, Mark


    This paper uses supermarket scanner data to estimate brand- and packaging-specific own- and cross-price elasticities for beer. We find that brand- and packaging-specific beer sales are highly price elastic. Cross-price elasticity estimates suggest that individuals are more likely to buy a higher-volume package of the same brand of beer than they are to switch brands. Policy simulations suggest that regulation of volume-based price discounts is potentially more effective than a tax increase at reducing beer consumption. Our results suggest that volume-based price discounting induces people to buy larger-volume packages of beer and may lead to an increased overall beer consumption. (c) 2008 John Wiley & Sons, Ltd.

  9. Increase in volume of lignocaine/adrenaline-containing local anaesthetic solution causes increase in acute postoperative pain after gingivectomy. (United States)

    Jorkjend, L; Skoglund, L A


    A randomized, single-blind, within-patient, crossover study was done in 44 patients (27 women and 17 men mean age 47 years, range 29-63) who had bilateral 'identical' gingivectomies. On one occasion a standard volume of local anaesthetic containing lignocaine 2% and adrenaline (1/80 000) was infiltrated into the mucosal tissue before operation. On the other occasion double the standard volume was infiltrated. The intensity of pain postoperatively was recorded by the patients on 100 mm visual analogue scale every hour for an 11-hour observation period. The intensity of pain when double volume had been given was significantly higher than that after the standard volume from 2 to 8 hours postoperatively (P gingivectomy.

  10. The public’s belief in climate change and its human cause are increasing over time (United States)

    Milfont, Taciano L.; Wilson, Marc S.; Sibley, Chris G.


    Polls examining public opinion on the subject of climate change are now commonplace, and one-off public opinion polls provide a snapshot of citizen's opinions that can inform policy and communication strategies. However, cross-sectional polls do not track opinions over time, thus making it impossible to ascertain whether key climate change beliefs held by the same group of individuals are changing or not. Here we examine the extent to which individual's level of agreement with two key beliefs ("climate change is real" and "climate change is caused by humans") remain stable or increase/decrease over a six-year period in New Zealand using latent growth curve modelling (n = 10,436). Data were drawn from the New Zealand Attitudes and Values Study, a probabilistic national panel study, and indicated that levels of agreement to both beliefs have steadily increased over the 2009–2015 period. Given that climate change beliefs and concerns are key predictors of climate change action, our findings suggest that a combination of targeted endeavors, as well as serendipitous events, may successfully convey the emergency of the issue. PMID:28319190

  11. The public's belief in climate change and its human cause are increasing over time. (United States)

    Milfont, Taciano L; Wilson, Marc S; Sibley, Chris G


    Polls examining public opinion on the subject of climate change are now commonplace, and one-off public opinion polls provide a snapshot of citizen's opinions that can inform policy and communication strategies. However, cross-sectional polls do not track opinions over time, thus making it impossible to ascertain whether key climate change beliefs held by the same group of individuals are changing or not. Here we examine the extent to which individual's level of agreement with two key beliefs ("climate change is real" and "climate change is caused by humans") remain stable or increase/decrease over a six-year period in New Zealand using latent growth curve modelling (n = 10,436). Data were drawn from the New Zealand Attitudes and Values Study, a probabilistic national panel study, and indicated that levels of agreement to both beliefs have steadily increased over the 2009-2015 period. Given that climate change beliefs and concerns are key predictors of climate change action, our findings suggest that a combination of targeted endeavors, as well as serendipitous events, may successfully convey the emergency of the issue.

  12. Iodine fortification may influence the age-related change in thyroid volume: a longitudinal population-based study (DanThyr)

    DEFF Research Database (Denmark)

    Krejbjerg, Anne; Bjergved, Lena; Pedersen, Inge Bülow


    Age-dependent differences in thyroid volume and enlargement had leveled out after the Danish iodization program. Thus, the previously observed increase in thyroid volume with age may have been caused by ID....

  13. Inconsistent detection of changes in cerebral blood volume by near infrared spectroscopy in standard clinical tests. (United States)

    Canova, D; Roatta, S; Bosone, D; Micieli, G


    The attractive possibility of near infrared spectroscopy (NIRS) to noninvasively assess cerebral blood volume and oxygenation is challenged by the possible interference from extracranial tissues. However, to what extent this may affect cerebral NIRS monitoring during standard clinical tests is ignored. To address this issue, 29 healthy subjects underwent a randomized sequence of three maneuvers that differently affect intra- and extracranial circulation: Valsalva maneuver (VM), hyperventilation (HV), and head-up tilt (HUT). Putative intracranial ("i") and extracranial ("e") NIRS signals were collected from the forehead and from the cheek, respectively, and acquired together with cutaneous plethysmography at the forehead (PPG), cerebral blood velocity from the middle cerebral artery, and arterial blood pressure. Extracranial contribution to cerebral NIRS monitoring was investigated by comparing Beer-Lambert (BL) and spatially resolved spectroscopy (SRS) blood volume indicators [the total hemoglobin concentration (tHb) and the total hemoglobin index, (THI)] and by correlating their changes with changes in extracranial circulation. While THIe and tHbe generally provided concordant indications, tHbi and THIi exhibited opposite-sign changes in a high percentage of cases (VM: 46%; HV: 31%; HUT: 40%). Moreover, tHbi was correlated with THIi only during HV (P < 0.05), not during VM and HUT, while it correlated with PPG in all three maneuvers (P < 0.01). These results evidence that extracranial circulation may markedly affect BL parameters in a high percentage of cases, even during standard clinical tests. Surface plethysmography at the forehead is suggested as complementary monitoring helpful in the interpretation of cerebral NIRS parameters.

  14. Causes and Consequences of Age-Related Changes in DNA Methylation: A Role for ROS?

    Directory of Open Access Journals (Sweden)

    Franka J. Rang


    Full Text Available Recent genome-wide analysis of C-phosphate-G (CpG sites has shown that the DNA methylome changes with increasing age, giving rise to genome-wide hypomethylation with site‑specific incidences of hypermethylation. This notion has received a lot of attention, as it potentially explains why aged organisms generally have a higher risk of age-related diseases. However, very little is known about the mechanisms that could cause the occurrence of these changes. Moreover, there does not appear to be a clear link between popular theories of aging and alterations in the methylome. Some of the most fruitful of these theories attribute an important role to reactive oxygen species, which seem to be responsible for an increase in oxidative damage to macromolecules, such as DNA, during the lifetime of an organism. In this review, the connection between changes in DNA methylation and these reactive oxygen species is discussed, as well as the effect of these changes on health. Deeper insights into the nature, causes and consequences of the aging methylome might provide a deeper understanding of the molecular mechanisms of aging and eventually contribute to the development of new diagnostic and therapeutic tools.

  15. Rotation change in the orientation of the centre-of-figure frame caused by large earthquakes (United States)

    Zhou, Jiangcun; Sun, Wenke; Jin, Shuanggen; Sun, Heping; Xu, Jianqiao


    A method to estimate the rotation change in the orientation of the centre-of-figure (CF) frame caused by earthquakes is proposed for the first time. This method involves using the point dislocation theory based on a spherical, non-rotating, perfectly elastic and isotropic (SNREI) Earth. The rotation change in the orientation is related solely to the toroidal displacements of degree one induced by the vertical dip slip dislocation, and the spheroidal displacements induced by an earthquake have no contribution. The effects of two recent large earthquakes, the 2004 Sumatra and the 2011 Tohoku-Oki, are studied. Results showed that the Sumatra and Tohoku-Oki earthquakes both caused the CF frame to rotate by at least tens of μas (micro-arc-second). Although the visible co-seismic displacements are identified and removed from the coordinate time-series, the rotation change due to the unidentified ones and errors in removal is non-negligible. Therefore, the rotation change in the orientation of the CF frame due to seismic deformation should be taken into account in the future in reference frame and geodesy applications.

  16. Modeling Changes in Bed Surface Texture and Aquatic Habitat Caused by Run-of-River Hydropower Development (United States)

    Fuller, T. K.; Venditti, J. G.; Nelson, P. A.; Popescu, V.; Palen, W.


    Run-of-river (RoR) hydropower has emerged as an important alternative to large reservoir-based dams in the renewable energy portfolios of China, India, Canada, and other areas around the globe. RoR projects generate electricity by diverting a portion of the channel discharge through a large pipe for several kilometers downhill where it is used to drive turbines before being returned to the channel. Individual RoR projects are thought to be less disruptive to local ecosystems than large hydropower because they involve minimal water storage, more closely match the natural hydrograph downstream of the project, and are capable of bypassing trapped sediment. However, there is concern that temporary sediment supply disruption may degrade the productivity of salmon spawning habitat downstream of the dam by causing changes in the grain size distribution of bed surface sediment. We hypothesize that salmon populations will be most susceptible to disruptions in sediment supply in channels where; 1) sediment supply is high relative to transport capacity prior to RoR development, and 2) project design creates substantial sediment storage volume. Determining the geomorphic effect of RoR development on aquatic habitat requires many years of field data collection, and even then it can be difficult to link geomorphic change to RoR development alone. As an alternative, we used a one-dimensional morphodynamic model to test our hypothesis across a range of pre-development sediment supply conditions and sediment storage volumes. Our results confirm that coarsening of the median surface grain-size is greatest in cases where pre-development sediment supply was highest and sediment storage volumes were large enough to disrupt supply over the course of the annual hydrograph or longer. In cases where the pre-development sediment supply is low, coarsening of the median surface grain-size is less than 2 mm over a multiple-year disruption period. When sediment supply is restored, our results

  17. Changes in Stroke Volume Induced by Lung Recruitment Maneuver Predict Fluid Responsiveness in Mechanically Ventilated Patients in the Operating Room. (United States)

    Biais, Matthieu; Lanchon, Romain; Sesay, Musa; Le Gall, Lisa; Pereira, Bruno; Futier, Emmanuel; Nouette-Gaulain, Karine


    Lung recruitment maneuver induces a decrease in stroke volume, which is more pronounced in hypovolemic patients. The authors hypothesized that the magnitude of stroke volume reduction through lung recruitment maneuver could predict preload responsiveness. Twenty-eight mechanically ventilated patients with low tidal volume during general anesthesia were included. Heart rate, mean arterial pressure, stroke volume, and pulse pressure variations were recorded before lung recruitment maneuver (application of continuous positive airway pressure of 30 cm H2O for 30 s), during lung recruitment maneuver when stroke volume reached its minimal value, and before and after volume expansion (250 ml saline, 0.9%, infused during 10 min). Patients were considered as responders to fluid administration if stroke volume increased greater than or equal to 10%. Sixteen patients were responders. Lung recruitment maneuver induced a significant decrease in mean arterial pressure and stroke volume in both responders and nonresponders. Changes in stroke volume induced by lung recruitment maneuver were correlated with those induced by volume expansion (r = 0.56; P recruitment maneuver predicted fluid responsiveness with a sensitivity of 88% (95% CI, 62 to 98) and a specificity of 92% (95% CI, 62 to 99). Pulse pressure variations more than 6% before lung recruitment maneuver discriminated responders with a sensitivity of 69% (95% CI, 41 to 89) and a specificity of 75% (95% CI, 42 to 95). The area under receiver operating curves generated for changes in stroke volume induced by lung recruitment maneuver (0.96; 95% CI, 0.81 to 0.99) was significantly higher than that for pulse pressure variations (0.72; 95% CI, 0.52 to 0.88; P recruitment maneuver could predict preload responsiveness in mechanically ventilated patients in the operating room.

  18. Prediction of changes in groundwater dynamics caused by relocation of river embankments

    Directory of Open Access Journals (Sweden)

    U. Mohrlok


    Full Text Available Ecosystems in river valleys are affected mainly by the hydraulic conditions in wetlands including groundwater dynamics. The quantitative prediction of changes in groundwater dynamics caused by river embankment relocation requires numerical modelling using a physically-based approach. Groundwater recharge from the intermittently flooded river plains was determined by a leakage approach considering soil hydraulic properties. For the study area in the Elbe river valley north of Magdeburg, Germany, a calibrated groundwater flow model was established and the groundwater dynamics for the present situation as well as for the case of embankment relocation were simulated over a 14-year time period. Changes in groundwater depth derived from simulated groundwater levels occurred only during flood periods. By analysing the spatial distributions of changes in statistical parameters, those areas with significant impact on the ecosystems by embankment relocation can be determined. Keywords: groundwater dynamics,groundwater recharge, flood plains, soil hydraulic properties, numerical modelling, river embankment relocation

  19. Identification of Structural Changes Caused by Weed Infection in Agriculture by Optical and Radar Data (United States)

    Nador, Gizella; Surek, Gyorgy; Fenyes, Diana; Ocsai, Katalin; Linda Toth, Gracia; Akos Gera, David; Hubik, Iren; Simon, Andras; Torok, Cecilia


    In most cases the healthy, weed-free cropland has a regular geometric structure determined by sowing technique and plant-to-plant distances. Several plant diseases and weed infections can cause disorders and structural changes in cropland. According to our experience, this type of geometrical changes can be well detected by using polarimetric radar images (RADARSAT2, ALOS PALSAR) with different polarizations (dual, quad) and wavelengths (C, L band).We analyze agricultural damages resulting in structural changes in different croplands. In this paper we propose to complete the methodology of identifying these agricultural damages based on the integrated use of optical and radar satellite images. We focused on the detection of ragweed infection on sunflower lands. According to our results it is possible to develop a methodology based on the quantitative evaluation of polarimetric features which enables us to identify ragweed infected sunflower lands before the beginning of pollen scattering (beginning of August).

  20. Periodic changes in shallow lunat crust caused by Sun's heating and thermal diffusivity near the surface (United States)

    Tanimoto, T.; Eitzel, M.; Yano, T.


    Analysis of Apollo 17 data (continuous data from 1976 to 1977) by the cross-correlation approach for seismic noise led us to two new discoveries, one related to the source of noise and the other on the periodic changes in seismic parameters due to extreme temperature changes near the surface. It has been shown previously by Larose et al. (2005) that Green's functions, dominated by Rayleigh waves, can be retrieved from cross-correlation of seismic noise in Apollo 17 data. We first confirmed their correlation results and further analyzed the details in GreenA?"qfs functions. The first discovery is that the sources of noise that lead to construction of Green's functions are (most likely) thermal moonquakes. This is suggested in the Rayleigh-wave observations that show diurnal variation (29.5 days) in amplitudes, but one can directly confirm a correlation between the statistics of thermal moonquakes and Rayleigh wave amplitudes. This is in contrast to the terrestrial case where ocean-generated seismic noise plays a critical role in the cross-correlation approach. This has implications for future planetary seismology as many planets lack oceans but may have thermal quakes caused by drastic temperature changes near the surface. Second, diurnal temporal variations in group velocity are detected, showing a strong correlation with the temporal variation of lunar surface temperature. This can be explained by the Sun's thermal effects which cause changes in density and seismic velocities near the surface. These effects are measurable on the moon since surface temperature changes as much as 270 K within the diurnal period. Depending on the thermal diffusivity of the medium, the depth extent of this thermal effect varies considerably. Inversion for thermal diffusivity using the changes in group velocity dispersion resulted in an estimate 10**(-7) (m**2/s) for the upper few meters.

  1. Climate variability rather than overstocking causes recent large scale cover changes of Tibetan pastures (United States)

    Lehnert, L. W.; Wesche, K.; Trachte, K.; Reudenbach, C.; Bendix, J.


    The Tibetan Plateau (TP) is a globally important “water tower” that provides water for nearly 40% of the world’s population. This supply function is claimed to be threatened by pasture degradation on the TP and the associated loss of water regulation functions. However, neither potential large scale degradation changes nor their drivers are known. Here, we analyse trends in a high-resolution dataset of grassland cover to determine the interactions among vegetation dynamics, climate change and human impacts on the TP. The results reveal that vegetation changes have regionally different triggers: While the vegetation cover has increased since the year 2000 in the north-eastern part of the TP due to an increase in precipitation, it has declined in the central and western parts of the TP due to rising air temperature and declining precipitation. Increasing livestock numbers as a result of land use changes exacerbated the negative trends but were not their exclusive driver. Thus, we conclude that climate variability instead of overgrazing has been the primary cause for large scale vegetation cover changes on the TP since the new millennium. Since areas of positive and negative changes are almost equal in extent, pasture degradation is not generally proceeding.

  2. Causes of twentieth-century temperature change near the Earth's surface (United States)

    Tett, Simon F. B.; Stott, Peter A.; Allen, Myles R.; Ingram, William J.; Mitchell, John F. B.


    Observations of the Earth's near-surface temperature show a global-mean temperature increase of approximately 0.6K since 1900 (ref. 1), occurring from 1910 to 1940 and from 1970 to the present. The temperature change over the past 30-50 years is unlikely to be entirely due to internal climate variability and has been attributed to changes in the concentrations of greenhouse gases and sulphate aerosols due to human activity. Attribution of the warming early in the century has proved more elusive. Here we present a quantification of the possible contributions throughout the century from the four components most likely to be responsible for the large-scale temperature changes, of which two vary naturally (solar irradiance and stratospheric volcanic aerosols) and two have changed decisively due to anthropogenic influence (greenhouse gases and sulphate aerosols). The patterns of time/space changes in near-surface temperature due to the separate forcing components are simulated with a coupled atmosphere-ocean general circulation model, and a linear combination of these is fitted to observations. Thus our analysis is insensitive to errors in the simulated amplitude of these responses. We find that solar forcing may have contributed to the temperature changes early in the century, but anthropogenic causes combined with natural variability would also present a possible explanation. For the warming from 1946 to 1996 regardless of any possible amplification of solar or volcanic influence, we exclude purely natural forcing, and attribute it largely to the anthropogenic components.

  3. Obesity and the built environment: changes in environmental cues cause energy imbalances. (United States)

    Cohen, D A


    The past 30 years have seen dramatic changes in the food and physical activity environments, both of which contribute to the changes in human behavior that could explain obesity. This paper reviews documented changes in the food environment, changes in the physical activity environment and the mechanisms through which people respond to these environments, often without conscious awareness or control. The most important environmental changes have been increases in food accessibility, food salience and decreases in the cost of food. The increases in food marketing and advertising create food cues that artificially stimulate people to feel hungry. The existence of a metabolic pathway that allows excess energy to be stored as fat suggests that people were designed to overeat. Many internal mechanisms favor neurophysiologic responses to food cues that result in overconsumption. External cues, such as food abundance, food variety and food novelty, cause people to override internal signals of satiety. Other factors, such as conditioning and priming, tie food to other desirable outcomes, and thus increase the frequency that hunger is stimulated by environmental cues. People's natural response to the environmental cues are colored by framing, and judgments are flawed and biased depending on how information is presented. People lack insight into how the food environment affects them, and subsequently are unable to change the factors that are responsible for excessive energy consumption. Understanding the causal pathway for overconsumption will be necessary to interrupt the mechanisms that lead to obesity.

  4. Aloe vera affects changes induced in pulmonary tissue of mice caused by cigarette smoke inhalation. (United States)

    Koul, Ashwani; Bala, Shashi; Yasmeen; Arora, Neha


    This study was undertaken to determine the influence of Aloe vera (AV) on changes induced in pulmonary tissue of cigarette smoke (CS) inhaling mice. CS inhalation for 4 weeks caused pulmonary damage as evident by histoarchitectural alterations and enhanced serum and tissue lactate dehydrogenase (LDH) activities. CS inhalation also led to increased mucin production as revealed by mucicarmine and Alcian Blue-Periodic Acid Schiff (AB-PAS) staining. Studies on bronchoalveolar lavage fluid (balf) of CS exposed animals revealed structural changes in phospholipids and increase in surface tension when compared with control counterparts. These changes were accompanied by enhanced nitric oxide (NO) levels, citrulline levels, peroxidative damage, and differential modulation of antioxidant defense system. AV administration (seven weeks, 500 mg/kg b.w. daily) to CS inhaling mice led to modulation of CS induced pulmonary changes as revealed by lesser degree of histoarchitectural alterations, lesser mucin production, decreased NO levels, citrulline levels, peroxidative damage, and serum LDH activity. AV treatment to CS inhaling mice was associated with varying response to antioxidant defense system, however balf of CS + AV treated animals did not exhibit appreciable changes when compared with that of CS exposed animals. These observations suggest that AV has the potential to modulate CS induced changes in the pulmonary tissue which could have implications in management of CS associated pulmonary diseases, however, further investigations are required to explore its complete mechanism of action.

  5. Estimation of volume and mass and of changes in volume and mass of selected chat piles in the Picher mining district, Ottawa County, Oklahoma, 2005-10 (United States)

    Smith, S. Jerrod


    From the 1890s through the 1970s the Picher mining district in northeastern Ottawa County, Oklahoma, was the site of mining and processing of lead and zinc ore. When mining ceased in about 1979, as much as 165–300 million tons of mine tailings, locally referred to as “chat,” remained in the Picher mining district. Since 1979, some chat piles have been mined for aggregate materials and have decreased in volume and mass. Currently (2013), the land surface in the Picher mining district is covered by thousands of acres of chat, much of which remains on Indian trust land owned by allottees. The Bureau of Indian Affairs manages these allotted lands and oversees the sale and removal of chat from these properties. To help the Bureau of Indian Affairs better manage the sale and removal of chat, the U.S. Geological Survey, in cooperation with the Bureau of Indian Affairs, estimated the 2005 and 2010 volumes and masses of selected chat piles remaining on allotted lands in the Picher mining district. The U.S. Geological Survey also estimated the changes in volume and mass of these chat piles for the period 2005 through 2010. The 2005 and 2010 chat-pile volume and mass estimates were computed for 34 selected chat piles on 16 properties in the study area. All computations of volume and mass were performed on individual chat piles and on groups of chat piles in the same property. The Sooner property had the greatest estimated volume (4.644 million cubic yards) and mass (5.253 ± 0.473 million tons) of chat in 2010. Five of the selected properties (Sooner, Western, Lawyers, Skelton, and St. Joe) contained estimated chat volumes exceeding 1 million cubic yards and estimated chat masses exceeding 1 million tons in 2010. Four of the selected properties (Lucky Bill Humbah, Ta Mee Heh, Bird Dog, and St. Louis No. 6) contained estimated chat volumes of less than 0.1 million cubic yards and estimated chat masses of less than 0.1 million tons in 2010. The total volume of all

  6. Possible causes of the change of dynamics in glass-forming materials subjected to reduced dimension

    Energy Technology Data Exchange (ETDEWEB)

    Ngai, K.L. [Naval Research Lab., Washington, DC (United States); Rizos, A.K. [Univ. of Crete (Greece)


    There is currently many ongoing investigations of the change in the glass transition temperature when a material is reduced in dimension from the normal bulk state. The reduction in dimension can be accomplished by casting the material as thin films with or without a substrate or putting it in nanometer size pores. In this work, the authors explore possible causes of the change in dynamics of the bulk material when the glass-former is subjected to such modifications. The existence of a growing cooperative length scale L(T) with decreasing temperature in bulk fragile glass-forming liquids reaching the size of approximately 1.5--2.0 nm at the glass transition temperature is the basis of the consideration. When the reduced dimension is comparable to L(T{sub g}), cooperative dynamics within a length scale equal to L(T{sub g}) can no longer be maintained in all three dimensions throughout the sample. The imposed reduction of the cooperative length scale speeds up the dynamics and causes a reduction of the glass transition temperature. For polymeric glass-formers particularly at higher molecular weights, reduction of one dimension in thin films engenders orientation of the polymer chains when their radius of gyration becomes comparable to the film thickness. The latter is known to cause also a reduction of the glass transition temperature.

  7. The 1,800-year oceanic tidal cycle: a possible cause of rapid climate change. (United States)

    Keeling, C D; Whorf, T P


    Variations in solar irradiance are widely believed to explain climatic change on 20,000- to 100,000-year time-scales in accordance with the Milankovitch theory of the ice ages, but there is no conclusive evidence that variable irradiance can be the cause of abrupt fluctuations in climate on time-scales as short as 1,000 years. We propose that such abrupt millennial changes, seen in ice and sedimentary core records, were produced in part by well characterized, almost periodic variations in the strength of the global oceanic tide-raising forces caused by resonances in the periodic motions of the earth and moon. A well defined 1,800-year tidal cycle is associated with gradually shifting lunar declination from one episode of maximum tidal forcing on the centennial time-scale to the next. An amplitude modulation of this cycle occurs with an average period of about 5,000 years, associated with gradually shifting separation-intervals between perihelion and syzygy at maxima of the 1,800-year cycle. We propose that strong tidal forcing causes cooling at the sea surface by increasing vertical mixing in the oceans. On the millennial time-scale, this tidal hypothesis is supported by findings, from sedimentary records of ice-rafting debris, that ocean waters cooled close to the times predicted for strong tidal forcing.

  8. Self-heating probe instrument and method for measuring high temperature melting volume change rate of material (United States)

    Wang, Junwei; Wang, Zhiping; Lu, Yang; Cheng, Bo


    The castings defects are affected by the melting volume change rate of material. The change rate has an important effect on running safety of the high temperature thermal storage chamber, too. But the characteristics of existing measuring installations are complex structure, troublesome operation and low precision. In order to measure the melting volume change rate of material accurately and conveniently, a self-designed measuring instrument, self-heating probe instrument, and measuring method are described. Temperature in heating cavity is controlled by PID temperature controller; melting volume change rate υ and molten density are calculated based on the melt volume which is measured by the instrument. Positive and negative υ represent expansion and shrinkage of the sample volume after melting, respectively. Taking eutectic LiF+CaF2 for example, its melting volume change rate and melting density at 1 123 K are -20.6% and 2 651 kg·m-3 measured by this instrument, which is only 0.71% smaller than literature value. Density and melting volume change rate of industry pure aluminum at 973 K and analysis pure NaCl at 1 123 K are detected by the instrument too. The measure results are agreed with report values. Measuring error sources are analyzed and several improving measures are proposed. In theory, the measuring errors of the change rate and molten density which are measured by the self-designed instrument is nearly 1/20-1/50 of that measured by the refitted mandril thermal expansion instrument. The self-designed instrument and method have the advantages of simple structure, being easy to operate, extensive applicability for material, relatively high accuracy, and most importantly, temperature and sample vapor pressure have little effect on the measurement accuracy. The presented instrument and method solve the problems of complicated structure and procedures, and large measuring errors for the samples with high vapor pressure by existing installations.

  9. Influence of lung volume, fluid and capillary recruitment during positional changes and exercise on thoracic impedance in heart failure. (United States)

    Kim, Chul-Ho; Fuglestad, Matthew A; Richert, Maile L Ceridon; Shen, Win K; Johnson, Bruce D


    It is unclear how dynamic changes in pulmonary-capillary blood volume (Vc), alveolar lung volume (derived from end-inspiratory lung volume, EILV) and interstitial fluid (ratio of alveolar capillary membrane conductance and pulmonary capillary blood volume, Dm/Vc) influence lung impedance (Z(T)). The purpose of this study was to investigate if positional change and exercise result in increased EILV, Vc and/or lung interstitial fluid, and if Z(T) tracks these variables. 12 heart failure (HF) patients underwent measurements (Z(T), EILV, Vc/Dm) at rest in the upright and supine positions, during exercise and into recovery. Inspiratory capacity was obtained to provide consistent measures of EILV while assessing Z(T). Z(T) increased with lung volume during slow vital capacity maneuvers (p0.05). Impedance appears sensitive to changes in lung volume and body position which appear to generally overwhelm small acute changes in lung fluid when assed dynamically at rest or during exercise. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. Atomistic simulation study of the effect of martensitic transformation volume change on crack-tip material evolution and fracture toughness

    Energy Technology Data Exchange (ETDEWEB)

    Grujicic, M. [Clemson Univ., SC (United States). Dept. of Mechanical Engineering; Lai, S.G. [Clemson Univ., SC (United States). Dept. of Mechanical Engineering; Gumbsch, P. [Max Planck-Institut fur Metallforshung Institut fuer Werstoffwissenshaft, Seestrasse 92, D-7000 Stuttgart I (Germany)


    The effect of the sign of the F.C.C.{yields}B.C.C. martensitic transformation volume change in Fe-20Ni on material evolution in a region surrounding the crack tip and the accompanying change in the fracture resistance of the material have been investigated using molecular dynamics simulations. The interaction between atoms has been modeled using the embedded atom method (EAM) interatomic potentials. To obtain both the positive and the negative values of the transformation volume change, small adjustments had to be made in the EAM functions. These changes did not significantly affect of the key materials properties, such as the relative thermodynamic stability of the F.C.C. and B.C.C. structures, elastic constants, (11 anti 2){sub bcc} twin boundary energy, (10 anti 1){sub fcc}/(1 anti 21){sub bcc} interfacial energy, etc. The simulation results show that the sign of the transformation volume change has a profound effect on the material evolution and the path of the advancing crack. When the volume change is negative, the region ahead of the crack tip undergoes the transformation only after the other regions around the crack tip have already transformed. The crack tip undergoes a significant blunting and tends to stay on the original crack plane. In sharp contrast, when the volume change is positive, the region ahead of the crack tip transforms first and significant decohesion along the F.C.C./B.C.C. interfaces takes place. Consequently the crack tends to branch out. The effect of material evolution at the crack tip on the ability of the material to withstand further fracture has been quantified by calculating the Eshelby`s F{sub 1} conservation integral. The sign of the transformation volume change is found to have a major effect on the change of the F{sub 1} integral with the simulation time. (orig.)

  11. Negative Associations between Perceived Training Load, Volume and Changes in Physical Fitness in Professional Soccer Players

    Directory of Open Access Journals (Sweden)

    Asier Los Arcos, Raul Martínez-Santos, Javier Yanci, Jurdan Mendiguchia, Alberto Méndez-Villanueva


    Full Text Available The purpose of this study was to examine the usefulness of the rating of perceived exertion training load for monitoring changes in several aerobic fitness and neuromuscular performance variables during 9 weeks of soccer training in young professional players. Nineteen male soccer players (20.2 ± 1.9 years belonging to the same reserve team of a Spanish La Liga Club participated in this study. Countermovement jump (CMJ, CMJ arm swing, single leg CMJ, a sprint running test (i.e., 5 m and 15 m times and an aerobic fitness running test were performed at the start of the pre-season (Test 1 and 9 weeks later (Test 2. During 9 weeks, after each training session and match, players reported their rating of perceived exertion (RPE separately for respiratory (RPEres and leg musculature (RPEmus effort. The training load (TL was calculated by multiplying the RPE value by the duration in minutes of each training session or match. Accumulated RPEmus, and associated TL, as well as accumulated training volume were negatively correlated with the changes in most physical fitness attributes after 9 weeks of training (r = -0.51 to -0.64. Present results suggest that a high perception of leg muscular effort associated with training sessions and matches, as well as an excessive accumulation of training volume (time, can impair the improvement in several physical fitness variables believed to be relevant for on-field soccer performance. Therefore, the independent assessment of leg muscular effort to quantify TL can be an interesting additional monitoring measure in soccer training.

  12. Volume Change Measurement Of Collapsible Soil Stabilized With Lime And Waste Lime

    Directory of Open Access Journals (Sweden)

    Khawla A. Al-Juari


    Full Text Available This paper presents a series of laboratory tests to evaluate the effects of lime and waste lime on the volume change and strength characteristics of moderately collapsible soil selected from Al-Rashidia in Mosul city. The tests are performed at different percentages of lime and waste lime of 0, 0.25, 0.5, 1.0, 2.0, 3.0, 4.0, 6.0 and 8.0% by dry weight of soil. One dimensional compression tests are conducted to clarify the influences of relative compaction, compaction water content, vertical stress level and curing time on the volume change and strength characteristics.The results of this study indicated a decrease in the plasticity, swelling potential and swelling pressure of treated soil. The soil became non-plastic at (3&6% of lime and waste lime respectively. Swelling pressure and swelling potential reached to zero at 2% lime and  2&7 days of curing time.Unconfined compressive strength (UCS reached to maximum value at optimum stabilizers content. The UCS of lime treated soil is more than that treated by waste lime at different curing time. The collapse index and potential of treated soil are found less than that of natural soil and decrease with increasing stabilizer content until drop to zero at 2% lime. Collapsing increased continuously with applied stresses, but with curing time reached a maximum value at 2 day. On the other hand, collapsing of treated soil with lime is less than that  of waste lime treated soil at different curing time and stresses.

  13. Changes in lakes water volume and runoff over ungauged Sahelian watersheds (United States)

    Gal, L.; Grippa, M.; Hiernaux, P.; Peugeot, C.; Mougin, E.; Kergoat, L.


    A large part of the Sahel consists of endorheic hydrological systems, where reservoirs and lakes capture surface runoff during the rainy season, making water available during the dry season. Monitoring and understanding the dynamics of these lakes and their relationships to the ecohydrological evolution of the region is important to assess past, present and future changes of water resources in the Sahel. Yet, most of Sahelian watersheds are still ungauged or poorly gauged, which hinders the assessment of the water flows feeding the lakes and the overall runoff over their watershed. In this paper, a methodology is developed to estimate water inflow to lakes for ungauged watersheds. It is tested for the Agoufou lake in the Gourma region in Mali, for which in situ water height measurements and surface areas estimations by remote sensing are simultaneously available. A Height-Volume-Area (HVA) model is developed to relate water volume to water height and lake surface area. This model is combined to daily evaporation and precipitation to estimate water inflow to the lake, which approximates runoff over the whole watershed. The ratio between annual water inflow and precipitation increases over the last sixty years as a result of a significant increase in runoff coefficient over the Agoufou watershed. The method is then extended to derive water inflow to three other Sahelian lakes in Mauritania and Niger. No in situ measurements are available and lake surface areas estimation by remote sensing is the only source of information. Dry season surface area changes and estimated evaporation are used to select a suited VA relationship for each case. It is found that the ratio between annual water inflow and precipitation has also increased in the last 60 years over these watersheds, although trends at the Mauritanian site are not statistically significant. The remote sensing approach developed in this study can be easily applied to recent sensors such as Sentinel-2 or Landsat-8

  14. Characteristics and Causes of Changes of Pan Evaporation in China During 1957-2001

    Institute of Scientific and Technical Information of China (English)

    SHEN Shuanghe; SHENG Qiong


    Evaporation is an important component of surface heat and water balance, and is affected directly by land use and climate change. This paper studies the changes of evaporation in China associated with the global climate change, and explores characteristics of the corresponding regional water cycle variations. The 20-cm-caliber pan evaporation measurements collected from 427 meteorological stations in China from 1957 to 2001 are analyzed to disclose the small-pan evaporation variation trend in China and the associated causes. The results show that although the annual average temperature over China exhibits an upward tendency of 0.2℃/10 yr for the past 45 years, the pan evaporation on the whole has decreased by -34.12mm/10 yr. Nonetheless, a significant increase of pan evaporation is observed in a few areas such as the northern part of the Greater Hingan Mountains in Northeast China and the Beishan Mountains in Inner Mongolia. The largest decrease of pan evaporation lies in East China, northern parts of Northwest China,South China, and southern Tibet. An analysis of energy balance and aerodynamics using Penman's formula proves that the drop of pan evaporation in East China is mainly due to a significant decline of source energy for evaporation, while that in West China is mostly attributed to an aerodynamic reduction. The analysis on tendencies of various meteorological and other related factors shows that wind speed and sunshine hours are two most important factors causing the pan evaporation reduction in China.

  15. Changes in the palatal dimensions of mouth breathing children caused by nasal obstruction (United States)

    Indiarti, I. S.; Setyanto, D. B.; Kusumaningrum, A.; Budiardjo, S. B.


    During children’s growth and development, the breathing process plays an important role in craniofacial growth, especially of the palate. Nose breathing can stimulate the lateral growth of the maxilla, thus making the palate flat. Disturbances in nose breathing caused by nasal obstruction such as allergic rhinitis, adenoid hypertrophy, rhinosinusitis, nasal polyps, and obstructive sleep apnea can lead to a mouth breathing habit in children. This habit can cause palatal dimension changes such as a narrow V-shaped maxillary arch and a high palatal vault. This study analyzed the relationship between the mouth breathing habit in children who have nasal obstruction and palatal dimension changes. A cross-sectional descriptive study was conducted with a consecutive sampling method on children 7-18 years old with a history of allergic rhinitis, adenoid hypertrophy, rhinosinusitis, nasal polyps, and obstructive sleep apnea in the Pediatric Respirology and Pediatric Immunology Allergy Outpatient Clinic Kiara Maternal and Child Health Center at Cipto Mangunkusumo Hospital in Jakarta. The palatal dimensions were measured by the height and transversal width of the hard palate of castings of each child’s upper dental arch using vernier calipers. Palatal dimension changes were found in children with a mouth breathing habit due to nasal obstruction.

  16. Simulation of hydrosedimentological impacts caused by climate change in the Apucaraninha River watershed, southern Brazil (United States)

    Ramos Iensen, I. R.; Bauer Schultz, G.; Dos Santos, I.


    Climate change can cause significant modifications in hydrosedimentological processes. Climate projections indicate the occurrence of extreme events, in terms of precipitation, droughts, floods and temperature. By increasing temperatures and altering precipitation regimes, climate change is expected to affect sediment dynamics. Predictions of the effects of climate change on streamflow and sediment yield vary widely, depending on the geographical location and climate scenarios used. Mathematical modelling can be used to simulate the hydrosedimentological processes in watersheds and enable the simulation of climate change effects on sediment yield. This paper aims to simulate the impacts of climate change hydrosedimentological dynamics in the Apucaraninha River watershed (504 km²), southern Brazil, considering the climate change scenarios A2 (pessimistic about the emissions of greenhouse gases) and B2 (optimistic about the emissions of greenhouse gases), developed by the IPCC. The Soil and Water Assessment Tool (SWAT) was used to evaluate the impacts of climate projections on the sediment yield in the Apucaraninha River watershed. The model was calibrated and validated using daily streamflow and sediment data from 1987 to 2012. The model presented satisfactory fit to the observed data allowing the reproduction of the current hydrological conditions of the watershed. Based on the satisfactory results in calibration and validation, the climate scenarios A2 and B2 were inserted to simulate streamflow and sediment conditions for the period 2071-2100. The results for both scenarios indicate that simulations of both climate scenarios resulted in changes in hydrosedimentological dynamics in the Apucaraninha River watershed, mainly in terms of decrease in average sediment yield due to the reduction in precipitation amount and increase in evapotranspiration. Our results also indicate that every 1% change in precipitation has resulted in 2.8% change in soil erosion and 1

  17. Radiation-induced changes of brain tissue after radiosurgery in patients with arteriovenous malformations: dose/volume-response relations

    Energy Technology Data Exchange (ETDEWEB)

    Levegruen, S.; Schlegel, W. [Dept. of Medical Physics, German Cancer Research Center (DKFZ), Heidelberg (Germany); Hof, H.; Debus, J. [Dept. of Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg (Germany); Essig, M. [Dept. of Radiology, German Cancer Research Center (DKFZ), Heidelberg (Germany)


    Purpose: to evaluate late radiation effects in the brain after radiosurgery of patients with cerebral arteriovenous malformations (AVMs) and to quantify dose/volume-response relations for radiation-induced changes of brain tissue identified on follow-up neuroimaging. Patients and methods: data from 73 AVM patients who had stereotactic linac radiosurgery at DKFZ (German Cancer Research Center), Heidelberg, Germany, were retrospectively analyzed. The endpoint of radiation-induced changes of brain tissue on follow-up magnetic resonance (MR) neuroimaging (i.e., edema and blood-brain-barrier breakdown [BBBB]) was evaluated. Each endpoint was further differentiated into three levels with respect to the extent of the image change (small, intermediate, and large). A previous analysis of the data found correlation of the endpoints with several dose/volume variables (DV) derived from each patient's dose distribution in the brain, including the mean dose in a volume of 20 cm{sup 3} (Dmean20) and the absolute brain volume (including the AVM target) receiving a dose of at least 12 Gy (V12). To quantify dose/volume-response relations, patients were ranked according to DV (i.e., Dmean20 and V12) and classified into four groups of equal size. For each group, the actuarial rates of developing the considered endpoints within 2.5 years after radiosurgery were determined from Kaplan-Meier estimates. The dose/volume-response curves were fitted with a sigmoid-shape logistic function and characterized by DV{sub 50}, the dose for a 50% incidence, and the slope parameter k. Results: dose/volume-response relations, based on two alternative, but correlated, dose distribution variables that are a function of both dose and volume, were observed for radiation-induced changes of brain tissue. DV{sub 50} values of fitted dose/volume-response curves for tissue changes of large extent (e.g., V12{sub 50} = 22.0 {+-} 2.6 cm{sup 3} and Dmean20{sub 50} = 17.8 {+-} 2.0 Gy for the combined endpoint

  18. The uncertainties and causes of the recent changes in global evapotranspiration from 1982 to 2010 (United States)

    Dong, Bo; Dai, Aiguo


    Recent studies have shown considerable changes in terrestrial evapotranspiration (ET) since the early 1980s, but the causes of these changes remain unclear. In this study, the relative contributions of external climate forcing and internal climate variability to the recent ET changes are examined. Three datasets of global terrestrial ET and the CMIP5 multi-model ensemble mean ET are analyzed, respectively, to quantify the apparent and externally-forced ET changes, while the unforced ET variations are estimated as the apparent ET minus the forced component. Large discrepancies of the ET estimates, in terms of their trend, variability, and temperature- and precipitation-dependence, are found among the three datasets. Results show that the forced global-mean ET exhibits an upward trend of 0.08 mm day-1 century-1 from 1982 to 2010. The forced ET also contains considerable multi-year to decadal variations during the latter half of the 20th century that are caused by volcanic aerosols. The spatial patterns and interannual variations of the forced ET are more closely linked to precipitation than temperature. After removing the forced component, the global-mean ET shows a trend ranging from -0.07 to 0.06 mm day-1 century-1 during 1982-2010 with varying spatial patterns among the three datasets. Furthermore, linkages between the unforced ET and internal climate modes are examined. Variations in Pacific sea surface temperatures (SSTs) are found to be consistently correlated with ET over many land areas among the ET datasets. The results suggest that there are large uncertainties in our current estimates of global terrestrial ET for the recent decades, and the greenhouse gas (GHG) and aerosol external forcings account for a large part of the apparent trend in global-mean terrestrial ET since 1982, but Pacific SST and other internal climate variability dominate recent ET variations and changes over most regions.

  19. The Observation of the Change of TCE Caused by Different Acupuncture Stimulation

    Directory of Open Access Journals (Sweden)

    Tao Huang


    Full Text Available Purpose. To observe the change of transcutaneous CO2 emission on meridian points or nonacupoints when the different needle sensations were gotten and study the associativity between Deqi acupuncture and periphery constitution energy metabolism effect. Method. 20 healthy volunteers were punctured on Neiguan (P6 in different ways including sham, shallow, Deqi acupuncture, and Deqi plus pressed P5, and measured TCE of different points before, during, and after acupuncture. Result. Needle sensations of sham acupuncture and shallow acupuncture were less than those of Deqi acupuncture. TCE of meridian points increased significantly and showed the specificity of meridian/channels. Conclusion. Verum acupuncture could cause the stronger needling sensations including distention, aching, numbness, and tingling than sham and shallow acupuncture. The strength of needling sensation caused by Deqi acupuncture is moderate and brought the best curative effects in TCE measurement. Deqi acupuncture could improve the energy metabolism of the points on the corresponding meridian/channel.

  20. The Observation of the Change of TCE Caused by Different Acupuncture Stimulation. (United States)

    Huang, Tao; Cheng, Xinnong


    Purpose. To observe the change of transcutaneous CO2 emission on meridian points or nonacupoints when the different needle sensations were gotten and study the associativity between Deqi acupuncture and periphery constitution energy metabolism effect. Method. 20 healthy volunteers were punctured on Neiguan (P6) in different ways including sham, shallow, Deqi acupuncture, and Deqi plus pressed P5, and measured TCE of different points before, during, and after acupuncture. Result. Needle sensations of sham acupuncture and shallow acupuncture were less than those of Deqi acupuncture. TCE of meridian points increased significantly and showed the specificity of meridian/channels. Conclusion. Verum acupuncture could cause the stronger needling sensations including distention, aching, numbness, and tingling than sham and shallow acupuncture. The strength of needling sensation caused by Deqi acupuncture is moderate and brought the best curative effects in TCE measurement. Deqi acupuncture could improve the energy metabolism of the points on the corresponding meridian/channel.

  1. Collective violence caused by climate change and how it threatens health and human rights. (United States)

    Levy, Barry S; Sidel, Victor W


    The weight of scientific evidence indicates that climate change is causally associated with collective violence. This evidence arises from individual studies over wide ranges of time and geographic location, and from two extensive meta-analyses. Complex pathways that underlie this association are not fully understood; however, increased ambient temperatures and extremes of rainfall, with their resultant adverse impacts on the environment and risk factors for violence, appear to play key roles. Collective violence due to climate change poses serious threats to health and human rights, including by causing morbidity and mortality directly and also indirectly by damage to the health-supporting infrastructure of society, forcing people to migrate from their homes and communities, damaging the environment, and diverting human and financial resources. This paper also briefly addresses issues for future research on the relationship between climate change and collective violence, the prevention of collective violence due to climate change, and States' obligations to protect human rights, to prevent collective violence, and to promote and support measures to mitigate and adapt to climate change.

  2. Research of the factors which cause strategic changes in organization’s behavior

    Directory of Open Access Journals (Sweden)

    O.A. Romakhova


    Full Text Available The aim of the article. The aim of the research is theoretical analysis of the influence of factors that cause strategic changes in organization’s behavior and systematization of these factors. Authors suggest recomendations for realization of the chosen directions of organization development. The results of the analysis. It is analyzed the main features of innovative strategy, organizational changes and organization’s behavior. Innovative strategy is understood as the algorithm of protracted purposeful measures necessary for the achievement of advantageous results under potential possibilities. Realization of innovative strategy supposes that organizations will be need to resort the system of strategic changes. Taking into account the folded theoretical and practical generalizations, it is possible to distinguish two groups of strategies that are the most actual nowadays – technological and marketing. During realization of innovative strategy to guidance of organization, it will be necessary to take into account the external and internal factors that influence the behavior of organization. It is possible to choose the directions of strategic changes that can increase the effectiveness of organization activity and terms of changeability of environment and the use of those possibilities that are opened. Conclusions and directions of further researches. Thus, it is possible to draw conclusions, that the offered systematization of factors of external and internal environment of organization is the basis for visualization of long-term prospects of organization, forming the directions of strategic changes in its behavior.

  3. Changes in physical activity and all-cause mortality in COPD. (United States)

    Vaes, Anouk W; Garcia-Aymerich, Judith; Marott, Jacob L; Benet, Marta; Groenen, Miriam T J; Schnohr, Peter; Franssen, Frits M E; Vestbo, Jørgen; Wouters, Emiel F M; Lange, Peter; Spruit, Martijn A


    Little is known about changes in physical activity in subjects with chronic obstructive pulmonary disease (COPD) and its impact on mortality. Therefore, we aimed to study changes in physical activity in subjects with and without COPD and the impact of physical activity on mortality risk. Subjects from the Copenhagen City Heart Study with at least two consecutive examinations were selected. Each examination included a self-administered questionnaire and clinical examination. 1270 COPD subjects and 8734 subjects without COPD (forced expiratory volume in 1 s 67±18 and 91±15% predicted, respectively) were included. COPD subjects with moderate or high baseline physical activity who reported low physical activity level at follow-up had the highest hazard ratios of mortality (1.73 and 2.35, respectively; both pphysical activity, no differences were found in survival between unchanged or increased physical activity at follow-up. In addition, subjects without COPD with low physical activity at follow-up had the highest hazard ratio of mortality, irrespective of baseline physical activity level (p≤0.05). A decline to low physical activity at follow-up was associated with an increased mortality risk in subjects with and without COPD. These observational data suggest that it is important to assess and encourage physical activity in the earliest stages of COPD in order to maintain a physical activity level that is as high as possible, as this is associated with better prognosis.

  4. Upgrade of Coastal Defence Structures Against Increased Loadings Caused by Climate Change

    DEFF Research Database (Denmark)

    Burcharth, Hans F.; Andersen, Thomas Lykke; Lara, Javier L.


    The paper presents a design exercise of upgrading a typical rock armoured revetment by modifying the structure profile and adding structure elements. Several concepts of upgrading are examined. A sea level rise corresponding to the mean of the IPCC 2007 predictions is used together with a slight...... increase in long-term wind/wave conditions as predicted for the North Sea by the Danish Coastal Authority. Both conditions of non-acceptable and acceptable increase in structure crest level are considered. Moreover, a scenario for steepening of the foreshore due to morphological changes caused by increased...

  5. Move or die: change in European catfish (Silurus glanis L. behaviour caused by oxygen deficiency

    Directory of Open Access Journals (Sweden)

    Daněk T.


    Full Text Available European catfish (Silurus glanis L. is a large predatory fish native to an extensive area in Europe. It has been introduced to its western and southern parts, where it is considered an invasive species with a negative impact on native fishes. European catfish is a territorial species exhibiting site fidelity. Cold water in winter usually leads catfish to exhibit notably low activity. Nevertheless, our telemetric study on 19 juvenile individuals of S. glanis provides information on their unexpected high activity and displacement in winter. Our data reveal that these behavioural changes were caused by oxygen deficiency. Our data also indicate that oxygen deficits may induce migrations of this species.

  6. Aquifer permeability change caused by a near-field earthquake, Canterbury, New Zealand (United States)

    Rutter, H. K.; Cox, S. C.; Dudley Ward, N. F.; Weir, J. J.


    The MW 7.1 Darfield (Canterbury) earthquake, 4 September 2010, generated widespread hydrological effects in New Zealand ranging from instantaneous changes of piezometric levels, to more sustained postseismic changes in spring flow, river discharge and groundwater levels, and increased turbidity and declined yields of water abstracted from wells. Four years later, piezometric levels remained elevated in deeper (>40 m) aquifers along the north-western (upper) side of the Canterbury Plains near the Greendale Fault, with changes in mean piezometric level reaching +13 m. Linear reservoir modeling (eigen modeling) suggests that sustained high groundwater was not the result of changes in abstraction or land surface recharge. Step-drawdown tests at six wells within 15 km of Greendale Fault were carried out prior to the earthquake and were retested following fault rupture. Eden-Hazel analysis of discharge/drawdown relationships discriminates potential sources of head losses, and how these changed (or otherwise) as a result of the earthquake. Objective application of Eden-Hazel analysis provided confidence levels for the interpretation, including when step tests provide reliable/unreliable estimates of transmissivity change. Increases in both aquifer losses and well losses were observed in four wells, reflecting both a change in sediment transmissivity and decrease in well efficiency. At two locations, the data were unable to provide results that can be interpreted with confidence. As the majority of local groundwater flow occurs through high-permeability open framework gravel lenses, we suggest that reduction in the permeability of these gravels, due to fine-sediment incursion, is the cause of the reduction in transmissivity and increase in well losses.

  7. Three Decades of Volume Change of a Small Greenlandic Glacier Using Ground Penetrating Radar, Structure from Motion, and Aerial Photogrammetry

    DEFF Research Database (Denmark)

    Marcer, M.; Stentoft, Peter Alexander; Bjerre, Elisa


    Glaciers in the Arctic are losing mass at an increasing rate. Here we use surface topography derived from Structure from Motion (SfM) and ice volume from ground penetrating radar (GPR) to describe the 2014 state of Aqqutikitsoq glacier (2.85 km) on Greenland's west coast. A photogrammetrically...... topography, the approach constitutes a viable alternative where the use of drones is not possible. Our investigations constitute the first glacier on Greenland's west coast where ice volume was determined and volume change calculated. The glacier's thinning rate is comparable to, for example, the Swiss Alps...

  8. Volume changes at macro- and nano-scale in epoxy resins studied by PALS and PVT experimental techniques

    Energy Technology Data Exchange (ETDEWEB)

    Somoza, A. [IFIMAT-UNCentro, Pinto 399, B7000GHG Tandil (Argentina) and CICPBA, Pinto 399, B7000GHG Tandil (Argentina)]. E-mail:; Salgueiro, W. [IFIMAT-UNCentro, Pinto 399, B7000GHG Tandil (Argentina); Goyanes, S. [LPMPyMC, Depto. de Fisica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon I, 1428 Buenos Aires (Argentina); Ramos, J. [Materials and Technology Group, Departamento de Ingenieria Quimica y M. Ambiente, Escuela University Politecnica, Universidad Pais Vasco/Euskal Herriko Unibertsitatea, Pz. Europa 1, 20018 Donostia/San Sebastian (Spain); Mondragon, I. [Materials and Technology Group, Departamento de Ingenieria Quimica y M. Ambiente, Escuela University Politecnica, Universidad Pais Vasco/Euskal Herriko Unibertsitatea, Pz. Europa 1, 20018 Donostia/San Sebastian (Spain)


    A systematic study on changes in the volumes at macro- and nano-scale in epoxy systems cured with selected aminic hardeners at different pre-cure temperatures is presented. Free- and macroscopic specific-volumes were measured by PALS and pressure-volume-temperature techniques, respectively. An analysis of the relation existing between macro- and nano-scales of the thermosetting networks developed by the different chemical structures is shown. The result obtained indicates that the structure of the hardeners governs the packing of the molecular chains of the epoxy network.

  9. Rates, trends, causes, and consequences of urban land-use change in the United States (United States)

    Acevedo, William; Taylor, Janis L.; Hester, Dave J.; Mladinich, Carol S.; Glavac, Sonya


    . Other economic and political incentives that shaped the urban environment included Federally backed home loans, credit and tax mechanisms that encouraged new development, and less restrictive municipal ordinances regarding building codes, environmental laws, and zoning regulations. Throughout the past two centuries land use changes associated with increasing urbanization have had impacts that resonate at local, regional, and even national scales. Landscape changes resulting from urbanization can be mapped and studied over time. Understanding these changes requires a study of the causes of change as related to social, economic, and political influences. Understanding these changes also requires analysis of how urbanization physically spreads across the landscape. The knowledge gained from studying urban land-use change can be helpful when it flows into local, regional, and national decisionmaking that relates to land-use decisions that impact the people, the economy, and the environment. Deriving a correlation between physical change and the explanations of the causes of change can help anticipate and mitigate the impacts of future change. Throughout the past two centuries changes to the Nation's urban areas are inextricably linked to population changes. The Nation's population started growing slowly along the eastern seaboard during the 17th and 18th centuries, accelerated in the second half of the 19th century, and then continued steadily spreading westward throughout the next hundred years. Currently, nearly 80 percent of the U.S. population resides in urban areas. Land area dedicated to urban use continues to expand, although differently than it has in the past. Most newly urbanized areas are much less densely populated and less intensively developed than they were 50 to 100 years ago.

  10. Present day sea level changes: observation and causes; Les variations actuelles du niveau de la mer: observations et causes

    Energy Technology Data Exchange (ETDEWEB)

    Lombard, A


    Whereas sea level has changed little over the last 2000 years, it has risen at a rate of about 2 mm/year during the 20. century. This unexpected sea level rise has been attributed to the anthropogenic global warming, recorded over several decades. Sea level variations have been measured globally and precisely for about 12 years due to satellite altimeter missions Topex/Poseidon and Jason-1. These observations indicate a global mean sea level rise of about 3 mm/year since 1993, a value significantly larger than observed during previous decades. Recent observations have allowed us to quantify the various climatic factors contributing to observed sea level change: thermal expansion of sea water due to ocean warming, melting of mountain glaciers and ice sheets, and changes in the land water reservoirs. A water budget based on these new observations allows us to partly explain the observed sea level rise. In particular, we show that the thermal expansion explains only 25% of the secular sea level rise as recorded by tide-gauges over the last 50 years, while it contributes about 50% of sea level rise observed over the last decade. Meanwhile, recent studies show that glacier and ice sheet melting could contribute the equivalent of 1 mm/year in sea level rise over the last decade. In addition, the high regional variability of sea level trends revealed by satellite altimetry is mainly due to thermal expansion. There is also an important decadal spatio-temporal variability in the ocean thermal expansion over the last 50 years, which seems to be controlled by natural climate fluctuations. We question for the first time the link between the decadal fluctuations in the ocean thermal expansion and in the land reservoirs, and indeed their climatic contribution to sea level change. Finally a preliminary analysis of GRACE spatial gravimetric observations over the oceans allows us to estimate the seasonal variations in mean sea level due to ocean water mass balance variations

  11. Estimating gravity changes caused by crustal strain: application to the Tibetan Plateau (United States)

    Yin, Zhi; Xu, Caijun


    Temporal gravimetry is an efficient tool for monitoring mass transfers, but distinguishing the contribution of each process to the measured signals is challenging. Few effective methods have been developed to estimate the changes in gravity caused by crustal strain for large-scale geophysical problems. To fill this research gap, we proposed a formula that describes a negative linear correlation between changes in gravity and crustal dilatational strain. Surface observations of gravity changes and dilatational strains were simulated using PSGRN/PSCMP, which is a numerical code used to calculate the surface response to fault dislocations, and the accuracy of the formula was quantitatively verified. Four parameters are required for this formula: the crustal dilatational strain, the crustal density, the Moho depth, and a coefficient that characterizes the degree of crust-mantle coupling. To illustrate the application of this new method to a natural case study, including specifying the values of the necessary parameters, the crustal strain-caused gravity changes (CSGCs) were calculated at 1° × 1° grid nodes over the Tibetan Plateau (TP). The CSGC model shows that most of the crust of the TP is undergoing extension, which generates negative gravity signals. The magnitude of the Tibetan CSGC model is approximately 0.2 μGal yr-1, which is similar to the results obtained from numerical modelling of the crustal tectonics of the Taiwanese Orogen. To evaluate the reliability of the Tibetan CSGC model, the uncertainties in the crustal dilatational strain, crustal density, Moho depth, and crust-mantle coupling factor were evaluated and then used to estimate the CSGC uncertainty by applying the error propagation law. The CSGC model was used to analyse the mass transfers of the TP. The results suggest that a significant mass accumulation process may be occurring beneath the crust of the northern TP.

  12. If this argument is true: Hashimotos disease causes chronic thyroid damage so in diseased elderly population the thyroid volumes must be low-retrospective US study


    Betul Tiryaki Bastug


    Background: Hashimoto thyroiditis is part of the spectrum of autoimmune thyroid diseases and is characterized by the destruction of thyroid cells by various cell and antibody-mediated immune processes. It primarily affects middle-aged women but also can occur in men and children. Hashimotos disease typically progresses slowly over years and causes chronic thyroid damage. This has to be thought that in diseased elderly population the thyroid volumes must be low. This paper shows if this argume...

  13. Atmospheric changes caused by galactic cosmic rays over the period 1960-2010 (United States)

    Jackman, Charles H.; Marsh, Daniel R.; Kinnison, Douglas E.; Mertens, Christopher J.; Fleming, Eric L.


    The Specified Dynamics version of the Whole Atmosphere Community Climate Model (SD-WACCM) and the Goddard Space Flight Center two-dimensional (GSFC 2-D) models are used to investigate the effect of galactic cosmic rays (GCRs) on the atmosphere over the 1960-2010 time period. The Nowcast of Atmospheric Ionizing Radiation for Aviation Safety (NAIRAS) computation of the GCR-caused ionization rates are used in these simulations. GCR-caused maximum NOx increases of 4-15 % are computed in the Southern polar troposphere with associated ozone increases of 1-2 %. NOx increases of ˜ 1-6 % are calculated for the lower stratosphere with associated ozone decreases of 0.2-1 %. The primary impact of GCRs on ozone was due to their production of NOx. The impact of GCRs varies with the atmospheric chlorine loading, sulfate aerosol loading, and solar cycle variation. Because of the interference between the NOx and ClOx ozone loss cycles (e.g., the ClO + NO2+ M → ClONO2+ M reaction) and the change in the importance of ClOx in the ozone budget, GCRs cause larger atmospheric impacts with less chlorine loading. GCRs also cause larger atmospheric impacts with less sulfate aerosol loading and for years closer to solar minimum. GCR-caused decreases of annual average global total ozone (AAGTO) were computed to be 0.2 % or less with GCR-caused column ozone increases between 1000 and 100 hPa of 0.08 % or less and GCR-caused column ozone decreases between 100 and 1 hPa of 0.23 % or less. Although these computed ozone impacts are small, GCRs provide a natural influence on ozone and need to be quantified over long time periods. This result serves as a lower limit because of the use of the ionization model NAIRAS/HZETRN which underestimates the ion production by neglecting electromagnetic and muon branches of the cosmic ray induced cascade. This will be corrected in future works.

  14. An assessment of uncertainties in using volume-area modelling for computing the twenty-first century glacier contribution to sea-level change

    Directory of Open Access Journals (Sweden)

    A. B. A. Slangen


    Full Text Available A large part of present-day sea-level change is formed by the melt of glaciers and ice caps (GIC. This study focuses on the uncertainties in the calculation of the GIC contribution on a century timescale. The model used is based on volume-area scaling, combined with the mass balance sensitivity of the GIC. We assess different aspects that contribute to the uncertainty in the prediction of the contribution of GIC to future sea-level rise, such as (1 the volume-area scaling method (scaling factor, (2 the glacier data, (3 the climate models, and (4 the emission scenario. Additionally, a comparison of the model results to the 20th century GIC contribution is presented.

    We find that small variations in the scaling factor cause significant variations in the initial volume of the glaciers, but only limited variations in the glacier volume change. If two existing glacier inventories are tuned such that the initial volume is the same, the GIC sea-level contribution over 100 yr differs by 0.027 m or 18 %. It appears that the mass balance sensitivity is also important: variations of 20 % in the mass balance sensitivity have an impact of 17 % on the resulting sea-level projections. Another important factor is the choice of the climate model, as the GIC contribution to sea-level change largely depends on the temperature and precipitation taken from climate models. Connected to this is the choice of emission scenario, used to drive the climate models. Combining all the uncertainties examined in this study leads to a total uncertainty of 0.052 m or 35 % in the GIC contribution to global mean sea level. Reducing the variance in the climate models and improving the glacier inventories will significantly reduce the uncertainty in calculating the GIC contributions, and are therefore crucial actions to improve future sea-level projections.

  15. Distinguishing allogenic from autogenic causes of bed elevation change in late Quaternary alluvial stratigraphic records (United States)

    Daniels, J. Michael


    Allogenic and autogenic mechanisms both cause changes in the bed elevation of rivers and thereby influence the characteristics of alluvial stratigraphic records (ASRs). Allogenic forcing mechanisms can be grouped into five categories whose relative influence varies with timescale: climate, tectonism, base level, land use/land cover and direct human modification of channels. Late Quaternary ASRs are influenced by the greatest range of allogenic forcing variables with climate among the most important. Autogenic mechanisms of bed elevation change are ubiquitous throughout fluvial systems and are always time-transgressive. Autogenic bed elevation change propagates through drainage networks at predictable rates and results in a time-space envelope within which its effects are capable of operating. ASRs that can be correlated over geographical areas large enough and time intervals small enough to exist outside this envelope most likely result from allogenic forcing. This formulation represents a quantitative and geographic set of threshold criteria for distinguishing between autogenic and allogenic mechanisms. Over late Quaternary timescales (10 2 to 10 5 years) in tectonically stable regions climate change is the dominant allogenic mechanism and, therefore, the first-order control on the morphology, sedimentology, pedologic characteristics and chronology of alluvial stratigraphic records that meet or exceed the threshold criteria for demonstrating allogenic causality.

  16. a Solution to Low Rfm Fitting Precision of Planetary Orbiter Images Caused by Exposure Time Changing (United States)

    Liu, B.; Xu, B.; Di, K.; Jia, M.


    In this paper, we propose a new solution to the low RFM fitting precision caused by exposure time changing using sensor correction. First, we establish a new rigorous geometric model, with the same ephemerides, attitudes and sensor design parameters of Chang'E-2 and HRSC images, using an equal exposure time of each scan line. The original rigorous geometric model is also established. With a given height, we can establish the correspondence between the two rigorous models. Then we generate a sensor corrected image by resampling the original image using an average elevation or a digital elevation model. We found that the sensor corrected images can be used for topographic mapping which maintains almost the same precision of the original images under certain conditions. And RFM can fit rigorous geometric model of the sensor corrected image very well. Preliminary experimental results show that the RMS residual error of the RFM fitting can reach to 1/100 pixel level too. Using the proposed solution, sensors with changing exposure time can be precisely modelled by the generic RFM.

  17. Using ocean satellites altimetry to observe geoid change caused by large earthquakes (United States)

    Lun Chiang, Hui; Fong Chao, Benjamin


    The geoid is the gravitational equipotential surface that is closest to the shape of the real earth. Sea water, being fluid, flows to a lowest gravitational state such that the mean sea surface conforms to the geoid, while the dynamic height departure between them are caused by tides, winds, ocean currents, and other dynamic or even anthropogenic effects. Here we use the sea surface height data, from altimetry satellites of Topex/Poseidon, Jason-1 and Jason-2 to detect possible geoid changes due to three recent large earthquakes, namely the Sumatra-Andaman event of December 26 in 2004, Chile event of February 27 in 2010 and the Tohoku-Oki event of March 11 in 2011. Instead of applying directly the gridded sea surface height data processed by AVISO, we download the "along-track" altimetric data in the respective regions to take advantage of their detailed information content and higher resolutions. With the data, we constructed for 1-year each the pre- and post-seismic sea surface height maps in order to detect the coseismic geoid changes, and analyzing longer time series for postseismic phenomena. We found moderate geoid change signals that are above the noise level. We compared them with the observed geoid change from the GRACE satellite data and with those calculated by elastic dislocation theory given seismic rupture models. The comparison is encouraging and promises further studies.

  18. A case of Z/E-isomers elution order inversion caused by cosolvent percentage change in supercritical fluid chromatography. (United States)

    Pokrovskiy, Oleg I; Ustinovich, Konstantin B; Usovich, Oleg I; Parenago, Olga O; Lunin, Valeriy V; Ovchinnikov, Denis V; Kosyakov, Dmitry S


    A case of elution order inversion caused by cosolvent percentage change in supercritical fluid chromatography was observed and investigated in some detail. Z- and E-isomers of phenylisobutylketone oxime experience an elution order reversal on most columns if the mobile phase consists of CO2 and alcohol. At lower percentages of alcohol Z-oxime is retained less, somewhere at 2-5% coelution occurs and at larger cosolvent volume elution order reverses - Z-oxime is eluted later than E-oxime. We suppose inversion with CO2-ROH phases happens due to a shift in balance between two main interactions governing retention. At low ROH percentages stationary phase surface is only slightly covered by ROH molecules so oximes primarily interact with adsorption sites via hydrogen bond formation. Due to intramolecular sterical hindrance Z-oxime is less able to form hydrogen bonds and consequently is eluted first. At higher percentages alcohols occupy most of strong hydrogen bonding sites on silica surface thus leaving non-specific electrostatic interactions predominantly responsible for Z/E selectivity. Z-oxime has a much larger dipole moment than E-oxime and at these conditions it is eluted later. Additional experimental data with CO2-CH3CN, hexane-iPrOH and CHF3-ROH mobile phases supporting this explanation are presented.

  19. Tubular system volume changes in twitch fibres from toad and rat skeletal muscle assessed by confocal microscopy. (United States)

    Launikonis, Bradley S; Stephenson, D George


    The volume of the extracellular compartment (tubular system) within intact muscle fibres from cane toad and rat was measured under various conditions using confocal microscopy. Under physiological conditions at rest, the fractional volume of the tubular system (t-sys(Vol)) was 1.38 +/- 0.09 % (n = 17), 1.41 +/- 0.09 % (n = 12) and 0.83 +/- 0.07 % (n = 12) of the total fibre volume in the twitch fibres from toad iliofibularis muscle, rat extensor digitorum longus muscle and rat soleus muscle, respectively. In toad muscle fibres, the t-sys(Vol) decreased by 30 % when the tubular system was fully depolarized and decreased by 15 % when membrane cholesterol was depleted from the tubular system with methyl-beta-cyclodextrin but did not change as the sarcomere length was changed from 1.93 to 3.30 microm. There was also an increase by 30 % and a decrease by 25 % in t-sys(Vol) when toad fibres were equilibrated in solutions that were 2.5-fold hypertonic and 50 % hypotonic, respectively. When the changes in total fibre volume were taken into consideration, the t-sys(Vol) expressed as a percentage of the isotonic fibre volume did actually decrease as tonicity increased, revealing that the tubular system in intact fibres cannot be compressed below 0.9 % of the isotonic fibre volume. The results can be explained in terms of forces acting at the level of the tubular wall. These observations have important physiological implications showing that the tubular system is a dynamic membrane structure capable of changing its volume in response to the membrane potential, cholesterol depletion and osmotic stress but not when the sarcomere length is changed in resting muscle.

  20. Recent changes to the Gulf Stream causing widespread gas hydrate destabilization. (United States)

    Phrampus, Benjamin J; Hornbach, Matthew J


    The Gulf Stream is an ocean current that modulates climate in the Northern Hemisphere by transporting warm waters from the Gulf of Mexico into the North Atlantic and Arctic oceans. A changing Gulf Stream has the potential to thaw and convert hundreds of gigatonnes of frozen methane hydrate trapped below the sea floor into methane gas, increasing the risk of slope failure and methane release. How the Gulf Stream changes with time and what effect these changes have on methane hydrate stability is unclear. Here, using seismic data combined with thermal models, we show that recent changes in intermediate-depth ocean temperature associated with the Gulf Stream are rapidly destabilizing methane hydrate along a broad swathe of the North American margin. The area of active hydrate destabilization covers at least 10,000 square kilometres of the United States eastern margin, and occurs in a region prone to kilometre-scale slope failures. Previous hypothetical studies postulated that an increase of five degrees Celsius in intermediate-depth ocean temperatures could release enough methane to explain extreme global warming events like the Palaeocene-Eocene thermal maximum (PETM) and trigger widespread ocean acidification. Our analysis suggests that changes in Gulf Stream flow or temperature within the past 5,000 years or so are warming the western North Atlantic margin by up to eight degrees Celsius and are now triggering the destabilization of 2.5 gigatonnes of methane hydrate (about 0.2 per cent of that required to cause the PETM). This destabilization extends along hundreds of kilometres of the margin and may continue for centuries. It is unlikely that the western North Atlantic margin is the only area experiencing changing ocean currents; our estimate of 2.5 gigatonnes of destabilizing methane hydrate may therefore represent only a fraction of the methane hydrate currently destabilizing globally. The transport from ocean to atmosphere of any methane released--and thus its

  1. Volume and expansivity changes of micelle formation measured by pressure perturbation calorimetry. (United States)

    Fan, Helen Y; Nazari, Mozhgan; Chowdhury, Saria; Heerklotz, Heiko


    We present the application of pressure perturbation calorimetry (PPC) as a new method for the volumetric characterization of the micelle formation of surfactants. The evaluation is realized by a global fit of PPC curves at different surfactant concentration ranging, if possible, from below to far above the CMC. It is based on the knowledge of the temperature dependence of the CMC, which can for example be characterized by isothermal titration calorimetry. We demonstrate the new approach for decyl-β-maltopyranoside (DM). It shows a strong volume increase upon micelle formation of 16 ± 2.5 mL/mol (+4%) at 25 °C, and changes with temperature by -0.1 mL/(mol K). The apparent molar expansivity (E(S)) decreases upon micelle formation from 0.44 to 0.31 mL/(mol K) at 25 °C. Surprisingly, the temperature dependence of the expansivity of DM in solution (as compared with that of maltose) does not agree with the principal behavior described for polar (E(S)(T) decreasing) and hydrophobic (E(S)(T) increasing) solutes or moieties before. The results are discussed in terms of changes in hydration of the molecules and internal packing of the micelles and compared with the volumetric effects of transitions of proteins, DNA, lipids, and polymers.

  2. Effect of temperature on volume change behaviour of statically compacted kaolin clay

    Directory of Open Access Journals (Sweden)

    Ileme Ogechi


    Full Text Available Several soils are subjected to high temperature due to the environment where they are located or activities around them. For instance, upper layer of soils in tropical regions, soils around geothermal structures, clay barriers around nuclear waste repository systems. Numerous studies have pointed out that high temperature affects the hydro-mechanical properties of soils. Notwithstanding already existing studies, the influence of temperature on soils is still a challenge, as most of these studies are soil specific and cannot be inferred as the behaviour of all soils. This paper presents an experimental study on the influence of temperature on the volume change behaviour of statically compacted kaolin clay. Compacted samples were tested at varying temperatures using a suction controlled oedometer cell. The influence of temperature on the magnitude of volumetric strain occurring during mechanical and thermal loading was investigated. The study showed that an increase in temperature increased the magnitude of volumetric strain of the soil on loading. Additionally, the results presented in the light of LC curve showed that an increase in temperature resulted in the contraction and a change in the position of the LC curve.

  3. Traditional Medicare Versus Private Insurance: How Spending, Volume, And Price Change At Age Sixty-Five. (United States)

    Wallace, Jacob; Song, Zirui


    To slow the growth of Medicare spending, some policy makers have advocated raising the Medicare eligibility age from the current sixty-five years to sixty-seven years. For the majority of affected adults, this would delay entry into Medicare and increase the time they are covered by private insurance. Despite its policy importance, little is known about how such a change would affect national health care spending, which is the sum of health care spending for all consumers and payers-including governments. We examined how spending differed between Medicare and private insurance using longitudinal data on imaging and procedures for a national cohort of individuals who switched from private insurance to Medicare at age sixty-five. Using a regression discontinuity design, we found that spending fell by $38.56 per beneficiary per quarter-or 32.4 percent-upon entry into Medicare at age sixty-five. In contrast, we found no changes in the volume of services at age sixty-five. For the previously insured, entry into Medicare led to a large drop in spending driven by lower provider prices, which may reflect Medicare's purchasing power as a large insurer. These findings imply that increasing the Medicare eligibility age may raise national health care spending by replacing Medicare coverage with private insurance, which pays higher provider prices than Medicare does.

  4. Changes in nectar supply: A possible cause of widespread butterfly decline

    Institute of Scientific and Technical Information of China (English)

    Michiel F.WALLISDEVRIES; Chris A.M.Van SWAAY; Calijn L.PLATE


    Recent studies have documented declining trends of various groups of flower-visiting insects,even common butterfly species.Causes of these declines are still unclear but the loss of habitat quality across the wider countryside is thought to be a major factor.Nectar supply constitutes one of the main resources determining habitat quality.Yet,data on changes in nectar abundance are lacking.In this study,we provide the first analysis of changes in floral nectar abundance on a national scale and link these data to trends in butterfly species richness and abundance.We used transect data from the Dutch Butterfly Monitoring Scheme to compare two time periods:1994-1995 and 2007-2008.The results show that butterfly decline can indeed be linked to a substantial decline in overall flower abundance and specific nectar plants,such as thistles.The decline is as severe in reported flower generalists as in flower specialists.We suggest that eutrophication is a main cause of the decline of nectar sources.

  5. Climate change can cause complex responses in Baltic Sea macroalgae: A systematic review (United States)

    Takolander, Antti; Cabeza, Mar; Leskinen, Elina


    Estuarine macroalgae are important primary producers in aquatic ecosystems, and often foundation species providing structurally complex habitat. Climate change alters many abiotic factors that affect their long-term persistence and distribution. Here, we review the existing scientific literature on the tolerance of key macroalgal species in the Baltic Sea, the world's largest brackish water body. Elevated temperature is expected to intensify coastal eutrophication, further promoting growth of opportunistic, filamentous species, especially green algae, which are often species associated with intensive filamentous algal blooms. Declining salinities will push the distributions of marine species towards south, which may alter the Baltic Sea community compositions towards a more limnic state. Together with increasing eutrophication trends this may cause losses in marine-originating foundation species such as Fucus, causing severe biodiversity impacts. Experimental results on ocean acidification effects on macroalgae are mixed, with only few studies conducted in the Baltic Sea. We conclude that climate change can alter the structure and functioning of macroalgal ecosystems especially in the northern Baltic coastal areas, and can potentially act synergistically with eutrophication. We briefly discuss potential adaptation measures.

  6. Western US intermountain seismicity caused by changes in upper mantle flow. (United States)

    Becker, Thorsten W; Lowry, Anthony R; Faccenna, Claudio; Schmandt, Brandon; Borsa, Adrian; Yu, Chunquan


    Understanding the causes of intraplate earthquakes is challenging, as it requires extending plate tectonic theory to the dynamics of continental deformation. Seismicity in the western United States away from the plate boundary is clustered along a meandering, north-south trending 'intermountain' belt. This zone coincides with a transition from thin, actively deforming to thicker, less tectonically active crust and lithosphere. Although such structural gradients have been invoked to explain seismicity localization, the underlying cause of seismicity remains unclear. Here we show results from improved mantle flow models that reveal a relationship between seismicity and the rate change of 'dynamic topography' (that is, vertical normal stress from mantle flow). The associated predictive skill is greater than that of any of the other forcings we examined. We suggest that active mantle flow is a major contributor to seismogenic intraplate deformation, while gravitational potential energy variations have a minor role. Seismicity localization should occur where convective changes in vertical normal stress are modulated by lithospheric strength heterogeneities. Our results on deformation processes appear consistent with findings from other mobile belts, and imply that mantle flow plays a significant and quantifiable part in shaping topography, tectonics, and seismic hazard within intraplate settings.

  7. Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression

    DEFF Research Database (Denmark)

    Jørgensen, A.; Magnusson, P.; Hanson, Lars G.


    , and metabolite changes in 19 patients receiving ECT for severe depression. Other regions of interest included the amygdala, dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex, and hypothalamus. Patients received a 3T MR scan before ECT (TP1), 1 week (TP2), and 4 weeks (TP3) after ECT. Results......, and we were unable to identify a spectral signature at 1.30 ppm previously suggested to reflect neurogenesis induced by ECT. None of the brain imaging measures correlated to the clinical response. Conclusion: Our findings show that ECT causes a remodeling of brain structures involved in affective...

  8. Resistance exercise-induced fluid shifts: change in active muscle size and plasma volume (United States)

    Ploutz-Snyder, L. L.; Convertino, V. A.; Dudley, G. A.


    The purpose of this study was to test the hypothesis that the reduction in plasma volume (PV) induced by resistance exercise reflects fluid loss to the extravascular space and subsequently selective increase in cross-sectional area (CSA) of active but not inactive skeletal muscle. We compared changes in active and inactive muscle CSA and PV after barbell squat exercise. Magnetic resonance imaging (MRI) was used to quantify muscle involvement in exercise and to determine CSA of muscle groups or individual muscles [vasti (VS), adductor (Add), hamstring (Ham), and rectus femoris (RF)]. Muscle involvement in exercise was determined using exercise-induced contrast shift in spin-spin relaxation time (T2)-weighted MR images immediately postexercise. Alterations in muscle size were based on the mean CSA of individual slices. Hematocrit, hemoglobin, and Evans blue dye were used to estimate changes in PV. Muscle CSA and PV data were obtained preexercise and immediately postexercise and 15 and 45 min thereafter. A hierarchy of muscle involvement in exercise was found such that VS > Add > Ham > RF, with the Ham and RF showing essentially no involvement. CSA of the VS and Add muscle groups were increased 10 and 5%, respectively, immediately after exercise in each thigh with no changes in Ham and RF CSA. PV was decreased 22% immediately following exercise. The absolute loss of PV was correlated (r2 = 0.75) with absolute increase in muscle CSA immediately postexercise, supporting the notion that increased muscle size after resistance exercise reflects primarily fluid movement from the vascular space into active but not inactive muscle.

  9. [A case of AKI-caused minimal change nephrotic syndrome with concomitant pleuritis]. (United States)

    Watanabe, Renya; Abe, Yasuhiro; Sasaki, Masaru; Hamauchi, Aki; Yasunaga, Tomoe; Kurata, Satoshi; Yasuno, Tetsuhiko; Ito, Kenji; Sasatomi, Yoshie; Hisano, Satoshi; Nakashima, Hitoshi


    A twenty-year-old man complaining of chest pain was diagnosed as nephrotic syndrome complicated with pleural effusion and ascites. Despite treatment with antibiotics, his fever and high inflammatory reaction persisted. After hospitalization, his urine volume decreased and renal function had deteriorated. As he was suffering from dyspnea, hemodialysis was performed together with chest drainage. His pleural effusion was exudative, and IVIG treatment was added to the antibiotic treatment. He was diagnosed as suspected developed minimal change nephrotic syndrome (MCNS) and administered prednisolone intravenously. His renal function ameliorated as a result of this treatment, enabling him to withdraw from hemodialysis. Inflammatory reaction gradually decreased and his general condition improved. The result of a renal biopsy examination carried out after the hemodialysis treatment confirmed MCNS, which suggested that MCNS had induced acute kidney injury (AKI) atypically in this case. Generally AKI is not induced by MCNS in youth, but it may occur under severe inflammatory conditions. Physicians should be aware that MCNS in young patients may lead to the development of AKI requiring hemodialysis treatment.

  10. Effects of the volume changes and elastic-strain energies on the phase transition in the Li-Sn battery (United States)

    Zhang, Fan; Wang, Jianchuan; Liu, Shuhong; Du, Yong


    Sn and Sn-based compounds have been attracting a great interest as promising alternative materials for commercial anodes in lithium ion batteries. In this study, the phase evolution of the Li-Sn system during the lithiated processes and the effect of the elastic-strain energies caused by volume change on the phase transition are investigated by means of first-principles calculations. Our calculated results demonstrate that the distorted Li7Sn3 crystal tends to be formed in order to decrease the elastic-strain energy. In addition, our work indicates that the whole lithiated processes under the elastically constrained condition could be classified into two steps. The first step is the two-phase equilibrium process, in which the thermodynamic driving force is large enough to facilitate the phase transition and the plateau voltage could be established. The second step is considered to be the selective equilibrium, in which the thermodynamic driving force is not enough to facilitate the nucleation of the new equilibrium phase due to the elastically constrained conditions and the plateau voltage unformed. Besides, we find that in the Li0.4Sn matrix the nucleation of the αSn is more preferential than the βSn due to the effects of the elastic-strain energies.

  11. Premature mortality in Belgium in 1993-2009: leading causes, regional disparities and 15 years change. (United States)

    Renard, Françoise; Tafforeau, Jean; Deboosere, Patrick


    Reducing premature mortality is a crucial public health objective. After a long gap in the publication of Belgian mortality statistics, this paper presents the leading causes and the regional disparities in premature mortality in 2008-2009 and the changes since 1993. All deaths occurring in the periods 1993-1999 and 2003-2009, in people aged 1-74 residing in Belgium were included. The cause of death and population data for Belgium were provided by Statistics Belgium , while data for international comparisons were extracted from the WHO mortality database. Age-adjusted mortality rates and Person Year of Life Lost (PYLL) were calculated. The Rate Ratios were computed for regional and international comparisons, using the region or country with the lowest rate as reference; statistical significance was tested assuming a Poisson distribution of the number of deaths. The burden of premature mortality is much higher in men than in women (respectively 42% and 24% of the total number of deaths). The 2008-9 burden of premature mortality in Belgium reaches 6410 and 3440 PYLL per 100,000, respectively in males and females, ranking 4th and 3rd worst within the EU15. The disparities between Belgian regions are substantial: for overall premature mortality, respective excess of 40% and 20% among males, 30% and 20% among females are observed in Wallonia and Brussels as compared to Flanders. Also in cause specific mortality, Wallonia experiences a clear disadvantage compared to Flanders. Brussels shows an intermediate level for natural causes, but ranks differently for external causes, with less road accidents and suicide and more non-transport accidents than in the other regions. Age-adjusted premature mortality rates decreased by 29% among men and by 22% among women over a period of 15 years. Among men, circulatory diseases death rates decreased the fastest (-43.4%), followed by the neoplasms (-26.6%), the other natural causes (-21.0%) and the external causes (-20.8%). The larger

  12. Expression Changes of Early Response Genes in Lung Due to High Volume Ventilation

    Institute of Scientific and Technical Information of China (English)

    WANG Yuelan; YAO Shanglong; XIONG Ping


    Summary: The expression changes of early response genes due to ventilation with high volume in adult rats in vivo were observed. Forty SD male rats were randomly divided into control and 30, 60, 90 and 120 min ventilation groups, respectively (n=8 in each group). The animals were ventilated with tidal volume of 42 ml/kg and a PEEP level of 0 cmH2O at a rate of 40 breaths per minute in room air with a ventilator was given to the small animals. The expression of Egr-1, C-jun and IL-1β mRNA and proteins was detected by RT-PCR and immunohistochemical technique, respectively. The pathological changes in lung tissues were examined by HE staining. The results indicated that the expression of Egr-1, C-jun and IL-1β mRNA was detectable at 30th min after overventilation, but there was no significant difference in comparison with that in control group until overventilation for 60 min. However, at 90 and 120 min there was a significent increase as compared with 30 min or control group (P<0.05). The expression of Egr-1, C-jun and IL-1β deteced by immunohistochemical assay also showed a similar tendency of the gradual increase. In the 120 min ventilation group, the expression intensity of Egr-1, C-jun and IL-1β proteins in lung cells was the strongest and the nuclear translocation was increased markedly in comparison with any other groups (P<0.05). HE staining suggested that the degree of lung injury was aggravated gradually with the ventialtion going on and had a similar tendency to the expression of these early response genes and proteins. The current data suggested that overventilation activated and upregulated the expression of early response genes and the expression of these genes may be taken as the early signal to predict the onset and degree of lung injury. These results may demonstrated partially that the expression of early response genes induced by the mechanical stretch is associated with biochamic lung injury.

  13. Groundwater resources in Brazil: a review of possible impacts caused by climate change. (United States)

    Hirata, Ricardo; Conicelli, Bruno P


    Groundwater has a strategic role in times of climate change mainly because aquifers can provide water for long periods, even during very long and severe drought. The reduction and/or changes on the precipitation pattern can diminish the recharge mainly in unconfined aquifer, causing available groundwater restriction. The expected impact of long-term climate changes on the Brazilian aquifers for 2050 will lead to a severe reduction in 70% of recharge in the Northeast region aquifers (comparing to 2010 values), varying from 30% to 70% in the North region. Data referring to the South and Southeast regions are more favorable, with an increase in the relative recharge values from 30% to 100%. Another expected impact is the increase in demand and the decrease in the surface water availability that will make the population turn to aquifers as its main source of water for public or private uses in many regions of the country. Thus, an integrated use of surface and groundwater must therefore be considered in the water use planning. The solution of water scarcity is based on three factors: society growth awareness, better knowledge on the characteristics of hydraulic and chemical aquifers and effective management actions.

  14. When environmental changes do not cause geographic separation of fauna: differential responses of Baikalian invertebrates

    Directory of Open Access Journals (Sweden)

    Fazalova Varvara


    Full Text Available Abstract Background While the impact of climate fluctuations on the demographic histories of species caused by changes in habitat availability is well studied, populations of species from systems without geographic isolation have received comparatively little attention. Using CO1 mitochondrial sequences, we analysed phylogeographic patterns and demographic histories of populations of five species (four gastropod and one amphipod species co-occurring in the southwestern shore of Lake Baikal, an area where environmental oscillations have not resulted in geographical isolation of habitats. Results Species with stronger habitat preferences (gastropods B. turriformis, B. carinata and B. carinatocostata exhibit rather stable population sizes through their evolutionary history, and their phylogeographic pattern indicates moderate habitat fragmentation. Conversely, species without strong habitat preference (gastropod M. herderiana and amphipod G. fasciatus exhibit haplotype networks with a very abundant and widespread central haplotype and a big number of singleton haplotypes, while their reconstructed demographic histories show a population expansion starting about 25-50 thousand years ago, a period marked by climate warming and increase in diatom abundance as inferred from bottom-lake sedimentary cores. Conclusions In agreement with previous studies, we found that species reacted differently to the same environmental changes. Our results highlight the important role of dispersal ability and degree of ecological specialization in defining a species' response to environmental changes.

  15. Potential of marine reserves to cause community-wide changes beyond their boundaries. (United States)

    Guidetti, Paolo


    Fishing and other human activities can alter the abundances, size structure, and behavior of species playing key roles in shaping marine communities (e.g., keystone predators), which may in turn cause ecosystem shifts. Despite extensive evidence that cascading trophic interactions can underlie community-wide recovery inside no-take marine reserves by protecting high-level predators, the spatial extent of these effects into adjacent fished areas is unknown. I examined the potential for community-wide changes (i.e., the transition from overgrazed coralline barrens to macroalgal beds) in temperate rocky reefs within and around a no-take marine reserve. For this purpose I assessed distribution patterns of predatory fishes, sea urchins, and barrens across the reserve boundaries. Predatory fishes were significantly more abundant within the reserve than in adjacent locations, with moderate spillover across the reserve edges. In contrast, community-wide changes of benthic assemblages were apparent well beyond the reserve boundaries, which is consistent with temporary movements of predatory fishes (e.g., foraging migration) from the reserve to surrounding areas. My results suggest that no-take marine reserves can promote community-wide changes beyond their boundaries.

  16. Effects on electrochemical performances for host material caused by structure change of modifying material. (United States)

    Zhang, Yantao; Zhou, Enlou; Song, Dawei; Shi, Xixi; Wang, Xiaoqing; Guo, Jian; Zhang, Lianqi


    High ionic conductive lithium niobium oxides were selected as the modifying material to investigate the effects on the electrochemical performances for host material LiNi1/3Co1/3Mn1/3O2 caused by the structure change of the modifying material at various calcination temperatures and modifying amounts. X-ray diffraction (XRD) studies revealed that the structure of the modifying material was single LiNbO3 phase after being calcined at 500 °C and changed to LiNbO3-Li3NbO4 mixture phases at 600 and 700 °C, and further changed to single Li3NbO4 phase at 800 °C. Electrochemical tests displayed that both LiNbO3 and Li3NbO4 phases of modifying material could contribute to the improvement of the cycle performances for the host material, but the improvement degree of Li3NbO4 phase was more evident. The cycle performances and high rate performances of the modified host material (calcined at 700 °C) electrodes were improved with the right modifying amount.

  17. Phycobilisome truncation causes widespread proteome changes in Synechocystis sp. PCC 6803 (United States)

    Liberton, Michelle; Chrisler, William B.; Nicora, Carrie D.; Moore, Ronald J.; Smith, Richard D.; Koppenaal, David W.; Pakrasi, Himadri B.; Jacobs, Jon M.


    In cyanobacteria such as Synechocystis sp. PCC 6803, large antenna complexes called phycobilisomes (PBS) harvest light and transfer the energy to the photosynthetic reaction centers. Modification of the light harvesting machinery in cyanobacteria has widespread consequences, causing changes in cell morphology and physiology. In the current study, we investigated the effects of PBS truncation on the proteomes of three Synechocystis 6803 PBS antenna mutants. These range from the progressive truncation of phycocyanin rods in the CB and CK strains, to full removal of PBS in the PAL mutant. Comparative quantitative protein results revealed surprising changes in protein abundances in the mutant strains. Our results showed that PBS truncation in Synechocystis 6803 broadly impacted core cellular mechanisms beyond light harvesting and photosynthesis. Specifically, we observed dramatic alterations in membrane transport mechanisms, where the most severe PBS truncation in the PAL strain appeared to suppress the cellular utilization and regulation of bicarbonate and iron. These changes point to the role of PBS as a component critical to cell function, and demonstrate the continuing need to assess systems-wide protein based abundances to understand potential indirect phenotypic effects. PMID:28253354

  18. Phycobilisome truncation causes widespread proteome changes in Synechocystis sp. PCC 6803. (United States)

    Liberton, Michelle; Chrisler, William B; Nicora, Carrie D; Moore, Ronald J; Smith, Richard D; Koppenaal, David W; Pakrasi, Himadri B; Jacobs, Jon M


    In cyanobacteria such as Synechocystis sp. PCC 6803, large antenna complexes called phycobilisomes (PBS) harvest light and transfer the energy to the photosynthetic reaction centers. Modification of the light harvesting machinery in cyanobacteria has widespread consequences, causing changes in cell morphology and physiology. In the current study, we investigated the effects of PBS truncation on the proteomes of three Synechocystis 6803 PBS antenna mutants. These range from the progressive truncation of phycocyanin rods in the CB and CK strains, to full removal of PBS in the PAL mutant. Comparative quantitative protein results revealed surprising changes in protein abundances in the mutant strains. Our results showed that PBS truncation in Synechocystis 6803 broadly impacted core cellular mechanisms beyond light harvesting and photosynthesis. Specifically, we observed dramatic alterations in membrane transport mechanisms, where the most severe PBS truncation in the PAL strain appeared to suppress the cellular utilization and regulation of bicarbonate and iron. These changes point to the role of PBS as a component critical to cell function, and demonstrate the continuing need to assess systems-wide protein based abundances to understand potential indirect phenotypic effects.

  19. White matter volume change and its correlation with symptom severity in patients with schizophrenia: a VBM-DARTEL study. (United States)

    Kim, Gwang-Won; Jeong, Gwang-Woo


    The aim of this study was to evaluate the white matter (WM) volume change and its correlation with symptom severity in patients with schizophrenia using voxel-based morphometry. A total of 20 patients with schizophrenia and 20 age-matched healthy controls participated in this study. MR image data were processed using SPM8 software with diffeomorphic anatomical registration through an exponentiated Lie algebra (DARTEL) algorithm. The patients with schizophrenia showed significant decreases (P=0.042) in the WM volumes of the temporal lobe and superior frontal gyrus compared with the healthy controls. The WM volumes of the middle temporal gyrus were negatively correlated with the scores of both the Positive Subscale (Pearson's ρ=-0.68, P=0.001) and the Negative Subscale (ρ=-0.71, P=0.0005) in the Positive and Negative Syndrome Scale. In addition, the scores of the General Psychopathology Subscale were negatively correlated with the WM volumes of the superior frontal gyrus (ρ=-0.68, P=0.0009). This study evaluated the WM volume of patients with schizophrenia compared with healthy controls using DARTEI-based voxel-based morphometry and also assessed the correlation of the localized WM volume changes with the Positive and Negative Syndrome Scale. These findings will be useful to understand the neuropathology associated with WM abnormality in schizophrenia.

  20. Changes of orbital tissue volumes and proptosis in patients with thyroid extraocular muscle swelling after methylprednisolone pulse therapy. (United States)

    Higashiyama, Tomoaki; Nishida, Yasuhiro; Ohji, Masahito


    To evaluate the changes of orbital tissue volumes and proptosis after methylprednisolone pulse therapy in thyroid-associated ophthalmopathy (TAO). The cross-sectional areas of orbital tissues and proptosis were measured with magnetic resonance imaging in 40 orbits of 20 patients with TAO before and after methylprednisolone pulse therapy. The volumes of the whole orbit, orbital fatty tissue, and extraocular muscles were calculated. The volumes and proptosis were compared before and after treatment using a paired t test. Before treatment, the mean volumes were 33.0 ± 4.8 cm(3) in the whole orbit, 19.9 ± 4.1 cm(3) in the orbital fatty tissue, and 4.6 ± 1.2 cm(3) in the total extraocular muscles. After treatment, the mean volumes were 32.5 ± 4.4 cm(3) in the whole orbit, 19.9 ± 3.7 cm(3) in the orbital fatty tissue, and 4.0 ± 1.0 cm(3) in the total extraocular muscles. The mean volumes of the whole orbit (P = 0.17) and orbital fatty tissue (P = 0.82) were not significantly decreased after treatment, while the mean volume of total extraocular muscles was significantly decreased (P tissue seemed to be unchanged after methylprednisolone pulse therapy while that of total extraocular muscles was decreased. The proptosis value seemed to be unchanged after treatment.

  1. Evidence that climate change has caused 'emergence' of tick-borne diseases in Europe? (United States)

    Randolph, Sarah E


    Even though tick-borne disease systems are highly susceptible to climatic influences, climate change to date is not necessarily the cause of the marked increased incidence of a variety of tick-borne diseases in many parts of Europe over the past two decades. To test for causality, rather than coincidence, we need to examine whether the right sorts of climate change have occurred at the right time and in the right places to account for the observed heterogeneous temporal and spatial patterns of tick-borne disease 'emergence'. Tick-borne encephalitis (TBE) incidence, for example, showed a 3-fold step increase from 1983 to 1986 in Sweden, doubled in 1993 in the Czech Republic, increased even more dramatically in the same year in Lithuania and Poland, but declined markedly in 1997 in Hungary, Croatia and Slovenia. Within each country, TBE incidence has changed to different degrees in different regions. Because other tick-borne diseases, notably Lyme borreliosis, has commonly 'emerged' in parallel with TBE, we should first examine climate variables predicted to have a general effect on tick abundance, which has indeed increased in the past decade. These include temperature and moisture stress, which have seasonally differential impacts. Monthly mean records for 1960-2000 from the UK Climate Research Unit's interpolated global climate surface reveal that mean spring, spring-autumn and winter temperatures have all increased gradually over the past 40 years, but apparently most sharply in the late 1980s, when moisture stress also increased. These climate data do not reveal any obvious differences between sites where TBE did or did not 'emerge', and in Sweden increases in TBE pre-dated the onset of warmer springs and winters. If recorded climate changes cannot yet satisfactorily explain the temporal and spatial patterns of tick-borne disease change in Europe, the impact of biotic factors, such as increases in deer abundance and changing habitat structure, and of socio

  2. Short-axis epicardial volume change is a measure of cardiac left ventricular short-axis function, which is independent of myocardial wall thickness. (United States)

    Ugander, Martin; Carlsson, Marcus; Arheden, Håkan


    Fractional shortening (FS) by echocardiography is considered to represent the short-axis contribution to the stroke volume (SV), also called short-axis function. However, FS is mathematically coupled to the amount of myocardium, since it rearranges during atrioventricular plane displacement (AVPD). The SV is the sum of the volumes generated by 1) reduction in outer volume of the heart, and 2) inner AVPD. The long-axis contribution to the SV is generated by AVPD, and thus the short-axis contribution is the remaining outer volume change of the heart, which should be unrelated to myocardial wall thickness. We hypothesized that both endocardial and midwall shortening indexed to SV are dependent on myocardial wall thickness, whereas epicardial volume change (EVC) indexed to SV is not. Twelve healthy volunteers (normals), 12 athletes, and 12 patients with dilated cardiomyopathy (ejection fraction EVC was defined as SV minus long-axis function. Endocardial and midwall shortening were measured in a midventricular short-axis slice. Endocardial shortening/SV and midwall shortening/SV both varied in relation to end-diastolic myocardial wall thickness (R(2) = 0.16, P = 0.008 and R(2) = 0.14, P = 0.012, respectively), whereas EVC/SV did not (R(2) = 0.00, P = 0.37). FS is dependent on myocardial wall thickness, whereas EVC is not and therefore represents true short-axis function. This is not surprising considering that FS is mainly caused by rearrangement of myocardium secondary to long-axis function. FS is therefore not synonymous with short-axis function.

  3. Changes in circulating blood volume after infusion of hydroxyethyl starch 6% in critically ill patients

    DEFF Research Database (Denmark)

    Christensen, P; Andersson, J; Rasmussen, S E;


    The cardiovascular response to a volume challenge with hydroxyethyl starch (HES) (200/0.5) 6% depends on the relation between the volume of HES 6% infused and the expansion of the blood volume in critically ill patients. However, only relatively limited data exist on the plasma expanding effect...... of infusion of HES 6% in critically ill patients. The purpose of the study was to evaluate the variation in the expansion of the circulating blood volume (CBV) in critically ill patients after infusion of 500 ml of colloid (HES (200/0.5) 6%) using the carbon monoxide method....

  4. Brain-volume changes in young and middle-aged smokers: a DARTEL-based voxel-based morphometry study. (United States)

    Peng, Peng; Wang, Zhenchang; Jiang, Tao; Chu, Shuilian; Wang, Shuangkun; Xiao, Dan


    Many studies have reported brain volume changes in smokers. However, the volume differences of grey matter (GM) and white matter (WM) in young and middle-aged male smokers with different lifetime tobacco consumption (pack-years) remain uncertain. To examine the brain volume change, especially whether more pack-years smoking would be associated with smaller gray matter and white matter volume in young and middle-aged male smokers. We used a 3T MR scanner and performed Diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL)-based voxel-based morphometry on 53 long-term male smokers (30.72 ± 4.19 years) and 53 male healthy non-smokers (30.83 ± 5.18 years). We separated smokers to light and heavy smokers by pack-years and compared brain volume between different smoker groups and non-smokers. And then we did analysis of covariance (ANCOVA) between smokers and non-smokers by setting pack-years as covariates. Light and heavy smokers all displayed smaller GM and WM volume than non-smokers and more obviously in heavy smokers. The main smaller areas in light and heavy smokers were superior temporal gyrus, insula, middle occipital gyrus, posterior cingulate, precuneus in GM and posterior cingulate, thalamus and midbrain in WM, in addition, we also observed more pack-years smoking was associated with some certain smaller GM and WM volumes by ANCOVA. Young and middle-aged male smokers had many smaller brain areas than non-smokers. Some of these areas' volume had negative correlation with pack-years, while some had not. These may due to different pathophysiological role of smokings. © 2015 John Wiley & Sons Ltd.

  5. Development of new impact functions for global risk caused by climate change (United States)

    Miyazaki, C.


    The purpose of our study is to identify and quantify global-scale risks which can be caused by future climate change. In particular, we focus on the global-scale risks which have critical impacts to human environments. Use of impact functions is one of the common way to quantify global-scale risks. Output of impact function is climate impacts (e.g. economic damage by temperature increasing) and input can be global temperature increasing and/or socioeconomic condition (e.g. GDP). As the first step of study, we referred to AR5 WG II report (AR5, hereafter) and comprehensive inventories of climate change risks developed by Strategic R&D Area Project of the Environment Research and Technology Development Fund (ICA-RUS project). Then we extracted information which can be used to develop impact function from them. By following SPM/AR5, we focused on 11 sectors and extracted quantitative description on climate impacts from the AR5 and paper/reports cited in AR5. As a result, we identified about 40 risk items to focus as global-scale risks by climate change. Using the collected information, we tentatively made impact function on sea level rise and so on. In addition, we also extracted the impact functions used in Integrated Assessment Models (IAMs). The literature survey on IAM suggested the risk items considered in IAMs are limited. For instance, although FUND model provides detailed impact functions compared with most of other IAMs, its impact functions deal with only several sectors (e.g. agriculture, forestry, biodiversity, sea level rise, human health, energy demand and water resources). The survey on impact functions in IAMs also suggested impact function for abrupt climate change (so-called Tipping Element) is premature. Moreover, as example for quantifying health risk by our calculation, we also present the result on global-scale projection of the health burden attributable to childhood undernutrition (Ishida et al., 2014, ERL).

  6. Changes in Rational Economic Behavior Model, Caused By the Development of E-Commerce

    Directory of Open Access Journals (Sweden)

    Menzeleev Ilya, A.


    Full Text Available In the paper the author examines the origins of rationality concept and its transformation within the framework of economic science. According to the author, rationality is a fundamental concept both for philosophy and for economics. Changes in rational economic behavior model significantly effect on informal institutes (in short-term perspective and on formal institutes (in long-term period. In the paper it is said about significant changes taking place with humanity right now. Today it becomes more and more difficult to describe human behavior by uniform concept of rationality. Now people live in a world that is developing unprecedentedly fast, with the usage of incredible amount of information, countless tasks and social contacts. The development of the Internet and IT tools facilitate this process. Already since the midtwentieth century advertising and marketing has been influencing people’s lifestyle like politics or news. Media resources brands today are comparable to the resources of some political parties or even TV channels what means that advertising today is one of the main factors affecting consumers ' minds and their behavioral model, main feature of which is the premise of rationality or justification of actions. The author analyzes the changes of models of rationality over time and, above all, the changes caused by the development of Internet marketing and its tools for monitoring user activity and the impact on decision making in the Network. In conclusion a number of recommendations is given, which can help consumers to save an independence in making decisions in the Internet environment.

  7. Seasonal Changes in Bacterial Communities Cause Foaming in a Wastewater Treatment Plant. (United States)

    Wang, Ping; Yu, Zhisheng; Zhao, Jihong; Zhang, Hongxun


    Bio-foaming is a major problem in solid separation in activated sludge (AS) wastewater treatment systems. Understanding the changes in bacterial communities during sludge foaming is vital for explaining foam formation. Changes in bacterial communities in the foam, corresponding foaming AS, and non-foaming AS in a seasonal foaming wastewater treatment plant (WWTP) in Northern China were investigated by high-throughput pyrosequencing and molecular quantification-based approaches. We found that bacterial communities of the foam and the corresponding foaming AS were similar but markedly different from those of the non-foaming AS. Actinobacteria was the predominant phylum in the foam and the corresponding foaming AS, whereas Proteobacteria was predominant in the non-foaming AS. Similar to the results of most previous studies, our results showed that Candidatus "Microthrix parvicella" was the predominant filamentous bacteria in the foam and the corresponding foaming AS and was significantly enriched in the foam compared to the corresponding foaming AS. Its abundance decreased gradually with a slow disappearance of sludge foaming, indicating that its overgrowth had a direct relationship with sludge foaming. In addition to Candidatus M. parvicella, Tetrasphaera and Trichococcus might play a role in sludge foaming, because they supported the changes in AS microbial ecology for foam formation. The effluent water quality of the surveyed plant remained stable during the period of sludge foaming, but the microbial consortia responsible for nitrogen and phosphorus transformation and removal markedly changed compared to that in the non-foaming AS. This study adds to the previous understanding of bacterial communities causing foaming in WWTPs.

  8. Exposure to cobalt causes transcriptomic and proteomic changes in two rat liver derived cell lines. (United States)

    Permenter, Matthew G; Dennis, William E; Sutto, Thomas E; Jackson, David A; Lewis, John A; Stallings, Jonathan D


    Cobalt is a transition group metal present in trace amounts in the human diet, but in larger doses it can be acutely toxic or cause adverse health effects in chronic exposures. Its use in many industrial processes and alloys worldwide presents opportunities for occupational exposures, including military personnel. While the toxic effects of cobalt have been widely studied, the exact mechanisms of toxicity remain unclear. In order to further elucidate these mechanisms and identify potential biomarkers of exposure or effect, we exposed two rat liver-derived cell lines, H4-II-E-C3 and MH1C1, to two concentrations of cobalt chloride. We examined changes in gene expression using DNA microarrays in both cell lines and examined changes in cytoplasmic protein abundance in MH1C1 cells using mass spectrometry. We chose to closely examine differentially expressed genes and proteins changing in abundance in both cell lines in order to remove cell line specific effects. We identified enriched pathways, networks, and biological functions using commercial bioinformatic tools and manual annotation. Many of the genes, proteins, and pathways modulated by exposure to cobalt appear to be due to an induction of a hypoxic-like response and oxidative stress. Genes that may be differentially expressed due to a hypoxic-like response are involved in Hif-1α signaling, glycolysis, gluconeogenesis, and other energy metabolism related processes. Gene expression changes linked to oxidative stress are also known to be involved in the NRF2-mediated response, protein degradation, and glutathione production. Using microarray and mass spectrometry analysis, we were able to identify modulated genes and proteins, further elucidate the mechanisms of toxicity of cobalt, and identify biomarkers of exposure and effect in vitro, thus providing targets for focused in vivo studies.

  9. Exposure to cobalt causes transcriptomic and proteomic changes in two rat liver derived cell lines.

    Directory of Open Access Journals (Sweden)

    Matthew G Permenter

    Full Text Available Cobalt is a transition group metal present in trace amounts in the human diet, but in larger doses it can be acutely toxic or cause adverse health effects in chronic exposures. Its use in many industrial processes and alloys worldwide presents opportunities for occupational exposures, including military personnel. While the toxic effects of cobalt have been widely studied, the exact mechanisms of toxicity remain unclear. In order to further elucidate these mechanisms and identify potential biomarkers of exposure or effect, we exposed two rat liver-derived cell lines, H4-II-E-C3 and MH1C1, to two concentrations of cobalt chloride. We examined changes in gene expression using DNA microarrays in both cell lines and examined changes in cytoplasmic protein abundance in MH1C1 cells using mass spectrometry. We chose to closely examine differentially expressed genes and proteins changing in abundance in both cell lines in order to remove cell line specific effects. We identified enriched pathways, networks, and biological functions using commercial bioinformatic tools and manual annotation. Many of the genes, proteins, and pathways modulated by exposure to cobalt appear to be due to an induction of a hypoxic-like response and oxidative stress. Genes that may be differentially expressed due to a hypoxic-like response are involved in Hif-1α signaling, glycolysis, gluconeogenesis, and other energy metabolism related processes. Gene expression changes linked to oxidative stress are also known to be involved in the NRF2-mediated response, protein degradation, and glutathione production. Using microarray and mass spectrometry analysis, we were able to identify modulated genes and proteins, further elucidate the mechanisms of toxicity of cobalt, and identify biomarkers of exposure and effect in vitro, thus providing targets for focused in vivo studies.

  10. Mitochondrial polymerase gamma dysfunction and aging cause cardiac nuclear DNA methylation changes. (United States)

    Koczor, Christopher A; Ludlow, Ivan; Fields, Earl; Jiao, Zhe; Ludaway, Tomika; Russ, Rodney; Lewis, William


    Cardiomyopathy (CM) is an intrinsic weakening of myocardium with contractile dysfunction and congestive heart failure (CHF). CHF has been postulated to result from decreased mitochondrial energy production and oxidative stress. Effects of decreased mitochondrial oxygen consumption also can accelerate with aging. We previously showed DNA methylation changes in human hearts with CM. This was associated with mitochondrial DNA depletion, being another molecular marker of CM. We examined the relationship between mitochondrial dysfunction and cardiac epigenetic DNA methylation changes in both young and old mice. We used genetically engineered C57Bl/6 mice transgenic for a cardiac-specific mutant of the mitochondrial polymerase-γ (termed Y955C). Y955C mice undergo left ventricular hypertrophy (LVH) at a young age (∼ 94 days old), and LVH decompensated to CHF at old age (∼ 255 days old). Results found 95 genes differentially expressed as a result of Y955C expression, while 4,452 genes were differentially expressed as a result of aging hearts. Moreover, cardiac DNA methylation patterns differed between Y955C (4,506 peaks with 68.5% hypomethylation) and aged hearts (73,286 peaks with 80.2% hypomethylated). Correlatively, of the 95 Y955C-dependent differentially expressed genes, 30 genes (31.6%) also displayed differential DNA methylation; in the 4,452 age-dependent differentially expressed genes, 342 genes (7.7%) displayed associated DNA methylation changes. Both Y955C and aging demonstrated significant enrichment of CACGTG-associated E-box motifs in differentially methylated regions. Cardiac mitochondrial polymerase dysfunction alters nuclear DNA methylation. Furthermore, aging causes a robust change in cardiac DNA methylation that is partially associated with mitochondrial polymerase dysfunction. Copyright © 2016 the American Physiological Society.

  11. Exposure to Cobalt Causes Transcriptomic and Proteomic Changes in Two Rat Liver Derived Cell Lines (United States)

    Permenter, Matthew G.; Dennis, William E.; Sutto, Thomas E.; Jackson, David A.; Lewis, John A.; Stallings, Jonathan D.


    Cobalt is a transition group metal present in trace amounts in the human diet, but in larger doses it can be acutely toxic or cause adverse health effects in chronic exposures. Its use in many industrial processes and alloys worldwide presents opportunities for occupational exposures, including military personnel. While the toxic effects of cobalt have been widely studied, the exact mechanisms of toxicity remain unclear. In order to further elucidate these mechanisms and identify potential biomarkers of exposure or effect, we exposed two rat liver-derived cell lines, H4-II-E-C3 and MH1C1, to two concentrations of cobalt chloride. We examined changes in gene expression using DNA microarrays in both cell lines and examined changes in cytoplasmic protein abundance in MH1C1 cells using mass spectrometry. We chose to closely examine differentially expressed genes and proteins changing in abundance in both cell lines in order to remove cell line specific effects. We identified enriched pathways, networks, and biological functions using commercial bioinformatic tools and manual annotation. Many of the genes, proteins, and pathways modulated by exposure to cobalt appear to be due to an induction of a hypoxic-like response and oxidative stress. Genes that may be differentially expressed due to a hypoxic-like response are involved in Hif-1α signaling, glycolysis, gluconeogenesis, and other energy metabolism related processes. Gene expression changes linked to oxidative stress are also known to be involved in the NRF2-mediated response, protein degradation, and glutathione production. Using microarray and mass spectrometry analysis, we were able to identify modulated genes and proteins, further elucidate the mechanisms of toxicity of cobalt, and identify biomarkers of exposure and effect in vitro, thus providing targets for focused in vivo studies. PMID:24386269

  12. Structural and functional changes in pulmonary macrophages during phagocytosis caused by natural zeolite-clinoptilolite

    Energy Technology Data Exchange (ETDEWEB)

    Kruglikov, G.G.; Velichkovskii, B.T.; Garmash, T.I.; Volkogonova, V.M. (Rossiiskii Gosudarstvennyi Meditsinskii Universitet, Moscow (Russian Federation))


    Invstigates cytotoxic properties of clinoptilolite and structural and functional state of pulmonary macrophages in the course of phagocytosis caused by exposure to clinoptilolite. Investigations were carried out on white rats with quartz dust and dust of black coal from the Kemerovo coal deposit used in two reference groups. Toxic dust was administered intratracheally in saline solution, coal dust in a 1% starch solution. Pathological processes in phagocytic cells observed using electron microscopy are described. More pronounced cytotoxic effects of clinoptilolite in comparison with those of coal dust are pointed out. The following pathological phenomena in cells were observed: vigorous phagocytic processes on clinoptilolite particles; active lysosome reaction and lipid accumulation; irreversible changes in mitochondrea; development of destructive types of macrophages. 5 refs.

  13. Humboldtian science, Creole meteorology, and the discovery of human-caused climate change in South America. (United States)

    Cushman, Gregory T


    The belief that human land use is capable of causing large-scale climatic change lies at the root of modern conservation thought and policy. The origins and popularization of this belief were deeply politicized. Alexander von Humboldt's treatment of the Lake Valencia basin in Venezuela and the desert coast of Peru as natural laboratories for observing the interaction between geophysical and cultural forces was central to this discovery, as was Humboldt's belief that European colonialism was especially destructive to the land. Humboldt's overt cultivation of disciples was critical to building the prestige of this discovery and popularizing the Humboldtian scientific program, which depended fundamentally on local observers, but willfully marginalized chorographic knowledge systems. In creating new, global forms of environmental understanding, Humboldtian science also generated new forms of ignorance.

  14. Measuring gravity change caused by water storage variations: Performance assessment under controlled conditions

    DEFF Research Database (Denmark)

    Christiansen, Lars; Lund, Sanne; Andersen, Ole Baltazar


    Subsurface water content is an important state variable in hydrological systems. Established methods to measure subsurface water content have a small support scale which causes scaling problems in many applications. Time-lapse relative gravimetry can give an integrated measure of soil water storage...... a sensitivity of 1μGal, corresponding to a layer of 0.024 m of water in an infinitely extended horizontal sheet. For gravity surveys using relative gravity meters, the precision is highly dependent on the methods used to operate the gravimeter in the field. Systematic errors, which are difficult to detect, can...... changes over tens to hundreds of cubic meters. The use of time-lapse gravimetry in hydrology has until recent years been limited by the large efforts required to obtain precise and accurate gravity data at the 1μGal (10−8ms−2) scale. A typical modern relative gravimeter, the Scintrex CG-5, has...

  15. The causes and consequences of changes in virulence following pathogen host shifts. (United States)

    Longdon, Ben; Hadfield, Jarrod D; Day, Jonathan P; Smith, Sophia C L; McGonigle, John E; Cogni, Rodrigo; Cao, Chuan; Jiggins, Francis M


    Emerging infectious diseases are often the result of a host shift, where the pathogen originates from a different host species. Virulence--the harm a pathogen does to its host-can be extremely high following a host shift (for example Ebola, HIV, and SARs), while other host shifts may go undetected as they cause few symptoms in the new host. Here we examine how virulence varies across host species by carrying out a large cross infection experiment using 48 species of Drosophilidae and an RNA virus. Host shifts resulted in dramatic variation in virulence, with benign infections in some species and rapid death in others. The change in virulence was highly predictable from the host phylogeny, with hosts clustering together in distinct clades displaying high or low virulence. High levels of virulence are associated with high viral loads, and this may determine the transmission rate of the virus.

  16. Changes in brown coal structure caused by coal-solubilizing microorganisms

    Energy Technology Data Exchange (ETDEWEB)

    Schmiers, H.; Koepsel, R.; Weber, A.; Winkelhoefer, M.; Grosse, S. [Technische Univ. Bergakademie Freiberg (Germany). Inst. fuer Energieverfahrenstechnik und Chemieingenieurwesen


    The phenomenon of coal solubilization caused by microorganisms has been explained by various mechanisms: extraction of non-covalently bonded polar components of the coal substance by biogenic agents (chelating agents, alkaline substances) and enzyme-catalyzed cleavage of covalent bonds by extracellular enzyme systems. For this it is assumed that bond cleavage occurs on the aliphatic carbon (methylene groups, aliphatic bridges or on ester groups). As the coal has usually been treated with oxidizing agents such as H{sub 2}O{sub 2} or HNO{sub 3} before bioconversion, there is a possibility that the result of bioconversion is overlaid with the effect of the chemical treatment. We therefore studied the structural changes in the organic coal substance during pre-oxidation with H{sub 2}O{sub 2}, treatment with MnP and conversion using the fungal strains of Trichoderma and Fusarium oxysporum. (orig.)

  17. Identification and model based assessment of the potential water retention caused by land-use changes

    Directory of Open Access Journals (Sweden)

    A. Wahren


    Full Text Available The extreme summer flood in the Elbe River watershed initiated a debate on the role of forest conversion and afforestation as measures for preventive flood protection. To quantify the effect of forest conversion and afforestation on flood runoff from catchments reliable model calculations are essential. The article overviews the present state of our work and provides an example for a model- based assessment of potential water retention caused by land-use changes in a catchment in the Central Ore Mountains (Saxony, Germany. The potential of flood control by land-use management measures is highly dependant on the site-specific soil and relief conditions and the rainfall event characteristics. The pre-event soil moisture is distinctly lower under forest land-use. Furthermore, infiltration, percolation in the subsoil is increased. These effects exist for small/medium-scale events whereas they become marginal for extreme events.

  18. Changes in selection regime cause loss of phenotypic plasticity in planktonic freshwater copepods. (United States)

    Sereda, Sergej Vital'evič; Wilke, Thomas; Schultheiß, Roland


    Rapid phenotypic adaptation is critical for populations facing environmental changes and can be facilitated by phenotypic plasticity in the selected traits. Whereas recurrent environmental fluctuations can favour the maintenance or de novo evolution of plasticity, strong selection is hypothesized to decrease plasticity or even fix the trait (genetic assimilation). Despite advances in the theoretical understanding of the impact of plasticity on diversification processes, comparatively little empirical data of populations undergoing diversification mediated by plasticity are available. Here we use the planktonic freshwater copepod Acanthodiaptomus denticornis from two lakes as model system to study UV stress responses of two phenotypically different populations under laboratory conditions. Our study reveals heritable lake- and sex-specific differences of behaviour, physiological plasticity, and mortality. We discuss specific selective scenarios causing these differences and argue that phenotypic plasticity will be higher when selection pressure is moderate, but will decrease or even be lost under stronger pressure.

  19. Does Reading Cause Later Intelligence? Accounting for Stability in Models of Change. (United States)

    Bailey, Drew H; Littlefield, Andrew K


    This study reanalyzes data presented by Ritchie, Bates, and Plomin (2015) who used a cross-lagged monozygotic twin differences design to test whether reading ability caused changes in intelligence. The authors used data from a sample of 1,890 monozygotic twin pairs tested on reading ability and intelligence at five occasions between the ages of 7 and 16, regressing twin differences in intelligence on twin differences in prior intelligence and twin differences in prior reading ability. Results from a state-trait model suggest that reported effects of reading ability on later intelligence may be artifacts of previously uncontrolled factors, both environmental in origin and stable during this developmental period, influencing both constructs throughout development. Implications for cognitive developmental theory and methods are discussed. © 2016 The Authors. Child Development © 2016 Society for Research in Child Development, Inc.

  20. [Soft tissues volumes changing in malar and cheek area after fat grafting]. (United States)

    Nadtochiy, A G; Grischenko, S V; Malitskaya, O A


    To improve the predictability of facial soft tissues fat grafting results tissue thickness dynamics before and 1 year postoperatively was assessed by means of ultrasonic method in 58 patients under standardized position of the ultrasonic transducer, physical and technical scanning conditions. The study revealed direct correlation of soft tissues thickness increase after fat grafting with the initial thickness of recipient area tissues. One year after fat grafting 60-65% of additional thickness remained in the lower regions of malar-cheek area (with the greatest soft tissues thickness), and only 25-27% preserved in the upper regions with the minimal initial thickness of soft tissues. I.e. to achieve necessary correction volume in a zone with small initial soft tissues thickness it is necessary to increase the amount of fat grafting stages. As the rates of soft tissues thickness in correction area change during 3-4 months after fat grafting remaining stable after this period it is expedient to assess postoperative results and to carry out repeated fat grafting not earlier than 4 months after operation.

  1. Numerical Modeling of Debris Flow Force Caused by Climate Change and Its application to Check Dam (United States)

    KIM, S. D.; Jun, K.; JUN, B. H.; Lee, H. J.; TAK, W. J.


    Due to global warming, climate change cause a super hurricane and heavy rainfall frequently. Heavy rainfall cause by debris flow in mountainous terrains, and disasters by debris flow force have continuously increased. The purpose of this study is to analyze the characteristics of debris flow force acting on the check dam. The numerical approach to the debris flow force was performed by the Finite Difference Method (FDM) based on the erosion-deposition combination model including the equation of continuity, mass conservation, and momentum conservation. In order to investigate behavior of the debris flow force according to the variance of supplying water discharge and channel slope angle, a rectangular straight channel and one closed type check dam was set up for conducting numerical simulations. As the supply water discharges increase, the curve of the impact force by debris flow becomes unstable and fluctuation with high impact force occurred as time passes. And the peak impact force showed a steeper slope and appeared more quickly, the high impact force undergoes a fluctuation with high speed, and acting on the check dam. At the mountainous upstream, strong rainfall energy provoke a repeat erosion and deposition which results in debris flow force causing much damage along the check dam at the mountainous place. The analyses of the present study help provide information to predict future debris flow force and how to design for the check dam. This research was supported by a grant [MPSS-NH-2014-74] through the Disaster and Safety Management Institute funded by Ministry of Public Safety and Security of Korean government

  2. Citrus tristeza virus (CTV) Causing Proteomic and Enzymatic Changes in Sweet Orange Variety “Westin” (United States)

    Dória, Milena Santos; de Sousa, Aurizângela Oliveira; Barbosa, Cristiane de Jesus; Costa, Márcio Gilberto Cardoso; Gesteira, Abelmon da Silva; Souza, Regina Martins; Freitas, Ana Camila Oliveira; Pirovani, Carlos Priminho


    Citrus Tristeza disease, caused by CTV (Citrus tristeza virus), committs citrus plantations around the world and specifically attacks phloem tissues of the plant. The virus exists as a mixture of more or less severe variants, which may or may not cause symptoms of Tristeza. The objective of this study was to analyze the changes caused by CTV in the proteome of stems of sweet orange, as well as in the activity and gene expression of antioxidant enzymes. The CTV-infected sweet orange displayed mild symptoms, which were characterized by the presence of sparse stem pitting throughout their stems. The presence of virus was confirmed by RT-PCR. Proteomic analysis by 2DE-PAGE-MS / MS revealed the identity of 40 proteins differentially expressed between CTV- infected and -non-infected samples. Of these, 33 were up-regulated and 7 were down-regulated in CTV-infected samples. Among the proteins identified stands out a specific from the virus, the coat protein. Other proteins identified are involved with oxidative stress and for this their enzymatic activity was measured. The activity of superoxide dismutase (SOD) was higher in CTV-infected samples, as catalase (CAT) showed higher activity in uninfected samples. The activity of guaiacol peroxidase (GPX) did not vary significantly between samples. However, ascorbate peroxidase (APX) was more active in the infected samples. The relative expression of the genes encoding CAT, SOD, APX and GPX was analyzed by quantitative real time PCR (RT-qPCR). The CTV-infected samples showed greater accumulation of transcripts, except for the CAT gene. This gene showed higher expression in the uninfected samples. Taken together, it can be concluded that the CTV affects the protein profile and activity and gene expression of antioxidant enzymes in plants infected by this virus. PMID:26207751

  3. Retinal functional change caused by adenoviral vector-mediated transfection of LacZ gene. (United States)

    Sakamoto, T; Ueno, H; Goto, Y; Oshima, Y; Yamanaka, I; Ishibashi, T; Inomata, H


    We examined the effect of insertion of an exogenous gene on retinal function to assess the rationale of adenoviral vector-mediated gene transfer for future gene therapy. An adenoviral vector expressing bacterial LacZ (AdCALacZ) was injected into the eyes of adult rats either intravitreally (group A) or subretinally (group B), and the gene expression and retinal function were thus examined at different time points after gene transfer for 3 weeks. X-Gal histostaining showed that neural retinal cells were transfected in group A and that retinal pigment epithelial cells were transfected in group B. The gene transfer was more efficient in group B (54.4% of the fixed retinal area was stained) than in group A (10.4%). The electroretinogram (ERG) revealed retinal dysfunction in the AdCALacZ-transfected rats even at the stage in which the histological damage was not apparent by electron microscopy and immunohistochemical studies for cytokeratin, S-100 protein, and glial fibrillary acidic protein. The ERG change was correlated with the intensity of inflammation, and retinal function recovered to the original level by 3 weeks, along with a diminution of inflammation. Functional changes were more evident in eyes treated with AdCALacZ than in those infected with adenoviral vector with no exogenous gene; however, no histological difference was observed between these groups, indicating that the insertion of exogenous gene itself affects retinal function. The results showed that different kinds of retinal cells could be gene-transferred by an adenoviral vector, depending on the application method. The retinal dysfunction caused by each adenoviral transfection method was caused by inflammation and the insertion of exogenous gene, and this retinal dysfunction was recoverable. In future gene therapy, special attention should be given to the method of exogenous gene insertion in the retina.

  4. Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium.

    Directory of Open Access Journals (Sweden)

    Silène T Wavre-Shapton

    Full Text Available The retinal pigment epithelium (RPE is a pigmented monolayer of cells lying between the photoreceptors and a layer of fenestrated capillaries, the choriocapillaris. Choroideremia (CHM is an X-linked progressive degeneration of these three layers caused by the loss of function of Rab Escort protein-1 (REP1. REP1 is involved in the prenylation of Rab proteins, key regulators of membrane trafficking. To study the pathological consequences of chronic disruption of membrane traffic in the RPE we used a cell type-specific knock-out mouse model of the disease, where the Chm/Rep1 gene is deleted only in pigmented cells (Chm(Flox, Tyr-Cre+. Transmission electron microscopy (TEM was used to quantitate the melanosome distribution in the RPE and immunofluorescent staining of rhodopsin was used to quantitate phagocytosed rod outer segments in retinal sections. The ultrastructure of the RPE and Bruch's membrane at different ages was characterised by TEM to analyse age-related changes occurring as a result of defects in membrane traffic pathways. Chm/Rep1 gene knockout in RPE cells resulted in reduced numbers of melanosomes in the apical processes and delayed phagosome degradation. In addition, the RPE accumulated pathological changes at 5-6 months of age similar to those observed in 2-year old controls. These included the intracellular accumulation of lipofuscin-containing deposits, disorganised basal infoldings and the extracellular accumulation of basal laminar and basal linear deposits. The phenotype of the Chm(Flox, Tyr-Cre+ mice suggests that loss of the Chm/Rep1 gene causes premature accumulation of features of aging in the RPE. Furthermore, the striking similarities between the present observations and some of the phenotypes reported in age-related macular degeneration (AMD suggest that membrane traffic defects may contribute to the pathogenesis of AMD.

  5. Anesthesia-related changes in information transfer may be caused by reduction in local information generation. (United States)

    Wollstadt, Patricia; Sellers, Kristin K; Hutt, Axel; Frohlich, Flavio; Wibral, Michael


    In anesthesia research it is an open question how general anesthetics lead to loss of consciousness (LOC). It has been proposed that LOC may be caused by the disruption of cortical information processing, preventing information integration. Therefore, recent studies investigating information processing under anesthesia focused on changes in information transfer, measured by transfer entropy (TE). However, often this complex technique was not applied rigorously, using time series in symbolic representation, or using TE differences without accounting for neural conduction delays, or without accounting for signal history. Here, we used current best-practice in TE estimation to investigate information transfer under anesthesia: We conducted simultaneous recordings in primary visual cortex (V1) and prefrontal cortex (PFC) of head-fixed ferrets in a dark environment under different levels of anesthesia (awake, 0.5% isoflurane, 1.0 % isoflurane). To elucidate reasons for changes in TE, we further quantified information processing within brain areas by estimating active information storage (AIS) as an estimator of predictable information, and Lempel-Ziv complexity (LZC) as an estimator of signal entropy. Under anesthesia, we found a reduction in information transfer (TE) between PFC and V1 with a stronger reduction for the feedback direction (PFC to V1), validating previous results. Furthermore, entropy (LZC) was reduced and activity became more predictable as indicated by higher values of AIS. We conclude that higher anesthesia concentrations indeed lead to reduced inter-areal information transfer, which may be partly caused by decreases in local entropy and increases in local predictability. In revealing a possible reason for reduced TE that is potentially independent of inter-areal coupling, we demonstrate the value of directly quantifying information processing in addition to focusing on dynamic properties such as coupling strength.

  6. Antarctic glaciation caused ocean circulation changes at the Eocene-Oligocene transition. (United States)

    Goldner, A; Herold, N; Huber, M


    Two main hypotheses compete to explain global cooling and the abrupt growth of the Antarctic ice sheet across the Eocene-Oligocene transition about 34 million years ago: thermal isolation of Antarctica due to southern ocean gateway opening, and declining atmospheric CO2 (refs 5, 6). Increases in ocean thermal stratification and circulation in proxies across the Eocene-Oligocene transition have been interpreted as a unique signature of gateway opening, but at present both mechanisms remain possible. Here, using a coupled ocean-atmosphere model, we show that the rise of Antarctic glaciation, rather than altered palaeogeography, is best able to explain the observed oceanographic changes. We find that growth of the Antarctic ice sheet caused enhanced northward transport of Antarctic intermediate water and invigorated the formation of Antarctic bottom water, fundamentally reorganizing ocean circulation. Conversely, gateway openings had much less impact on ocean thermal stratification and circulation. Our results support available evidence that CO2 drawdown--not gateway opening--caused Antarctic ice sheet growth, and further show that these feedbacks in turn altered ocean circulation. The precise timing and rate of glaciation, and thus its impacts on ocean circulation, reflect the balance between potentially positive feedbacks (increases in sea ice extent and enhanced primary productivity) and negative feedbacks (stronger southward heat transport and localized high-latitude warming). The Antarctic ice sheet had a complex, dynamic role in ocean circulation and heat fluxes during its initiation, and these processes are likely to operate in the future.

  7. Cellular Structural Changes in Candida albicans Caused by the Hydroalcoholic Extract from Sapindus saponaria L.

    Directory of Open Access Journals (Sweden)

    Cristiane S. Shinobu-Mesquita


    Full Text Available Vulvovaginal candidiasis (VVC is a disease caused by the abnormal growth of yeast-like fungi in the mucosa of the female genital tract. Candida albicans is the principal etiological agent involved in VVC, but reports have shown an increase in the prevalence of Candida non-C. albicans (CNCA cases, which complicates VVC treatment because CNCA does not respond well to antifungal therapy. Our group has reported the in vitro antifungal activity of extracts from Sapindus saponaria L. The present study used scanning electron microscopy and transmission electron microscopy to further evaluate the antifungal activity of hydroalcoholic extract from S. saponaria (HE against yeast obtained from VVC and structural changes induced by HE. We observed the antifungal activity of HE against 125 vaginal yeasts that belonged to four different species of the Candida genus and S. cerevisae. The results suggest that saponins that are present in HE act on the cell wall or membrane of yeast at the first moments after contact, causing damage to these structures and cell lysis.

  8. Investigations into the free-volume changes within starch/plasticizer/nanoclay systems using Positron Annihilation Lifetime Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Huihua, E-mail: [School of Health Sciences, Federation University Australia, Ballarat, Vic (Australia); Chaudhary, Deeptangshu, E-mail: [ERS Environmental Risk Solutions PTY LTD, Perth, WA (Australia); Campbell, Colin, E-mail: [ARC Centre of Excellence for Antimatter-Matter Studies (CAMS), Research School of Physics and Engineering, Australian National University, Canberra (Australia); Roberts, Jason, E-mail: [ARC Centre of Excellence for Antimatter-Matter Studies (CAMS), Research School of Physics and Engineering, Australian National University, Canberra (Australia); Buckman, Stephen, E-mail: [ARC Centre of Excellence for Antimatter-Matter Studies (CAMS), Research School of Physics and Engineering, Australian National University, Canberra (Australia); Sullivan, James, E-mail: [ARC Centre of Excellence for Antimatter-Matter Studies (CAMS), Research School of Physics and Engineering, Australian National University, Canberra (Australia)


    The free-volume of a matrix is a fundamental parameter that relates to its molecular and bulk characteristics, such as crystalline change and glass transition behavior. In starch-based bionanocomposite, we investigated the effect of the addition of montmorillonite nanoclay (MMT) and food plasticizers (glycerol and sorbitol) on changes of molecular pore size (including pore volume and pore distribution) using the Positron Annihilation Lifetime Spectroscopy (PALS) method. The results demonstrated counter-intuitive impact of MMT on the total free-volume where the total free-volume increased within the polymeric matrix. When compared to the pure matrix free-volume, the addition of MMT also resulted in the appearance of a broader distribution of the void sizes. The plasticizers, on the other hand, apparently occupied the void spaces, and therefore decreased the free-volume of the matrix. Further, together with the small angle X-ray scattering (SAXS) analysis, we concluded that this is a result of interplay between the plasticizer-plasticizer interactions and the polymer–plasticizer interactions. For example, in the starch/glycerol/MMT system, the pore radii slightly decrease upon the increasing of glycerol amount (OG210 = O.27 nm and OG220 = 0.26 nm), but the relative weight did increase with the increasing glycerol concentration. However, increasing the sorbitol amount increased the pore size from 0.23 nm(OS210) to 0.28 nm(OS220). Furthermore, the addition MMT in the OS010 system, promote the emergence of a new dateable pore radius(0.90 nm), and the total weight significantly increased from 13.70 (OS010) to 19.5% (OS210). We suggest that the pore variation (size and distribution) due to the MMT and plasticizers are reflected in the polymer glass transition and crystallinity because ultimately, the, total free-volume is a reflection of level of interactions existing within the bulk of these nanocomposites. - Highlights: • PALS is applied to explore the

  9. Reverse asymmetry and changes in brain structural volume of the basal ganglia in ADHD, developmental changes and the impact of stimulant medications. (United States)

    Paclt, Ivo; Pribilová, Nikol; Kollárová, Patricie; Kohoutová, Milada; Dezortová, Monika; Hájek, Milan; Csemy, Ladislav


    We discussed the cross section studies and the meta-analysis of published data in children and adolescents with ADHD (both drug naive and receiving stimulant medications), in comparison with healthy children and adolescents of the same age. In children and adolescents with ADHD the deceleration of the maturation dynamics of discrete CNS structures is found, volume reduction and decreased grey matter in prefrontal and occipital regions, which is accompanied by reverse asymmetry of the basal ganglia volume (putamen, nucleus caudate). The above mentioned developmental characteristics are valid only for the ADHD children, who have not been treated by stimulant medications. The stimulant treatment eliminates the mentioned changes into various extend. These developmental changes of CNS structures volume are missing in girls.

  10. Risk for colorectal cancer in ulcerative colitis: Changes, causes and management strategies

    Institute of Scientific and Technical Information of China (English)

    Peter Laszlo Lakatos; Laszlo Lakatos


    The risk of colorectal cancer for any patient with ulcerative colitis is known to be elevated, and is estimated to be 2% after 10 years, 8% after 20 years and 18% after 30 years of disease. Risk factors for cancer include extent and duration of ulcerative colitis, primary sclerosing cholangitis, a family history of sporadic colorectal cancer, severity of histologic bowel inflammation, and in some studies, young age at onset of colitis. In this review, the authors discuss recent epidemiological trends and causes for the observed changes. Population-based studies published within the past 5 years suggest that this risk has decreased over time, despite the low frequency of colectomies. The crude annual incidence rate of colorectal cancer in ulcerative colitis ranges from approximately 0.06% to 0.16% with a relative risk of 1.0-2.75. The exact mechanism for this change is unknown; it may partly be explained by the more widespread use of maintenance therapy and surveillance colonoscopy.

  11. Changes in main causes of death in Macao residents from 1986-2006

    Institute of Scientific and Technical Information of China (English)

    CHAN Man-si; CHEN Qing; LAM Christopher Wai-kei


    Background Since Macao's return of sovereignty to China in December 1999,the life style of Macao residents has changed.The aim of this study was to investigate changes of death patterns in Macao residents from 1986 to 2006 in order to identify the trends and patterns of major public health problems,which could provide the guidance for developing public health policies.Methods A retrospective study was conducted for this investigation.Research data were collected from official websites and statistical yearbooks and classified by the International Classification of Diseases (ICD)-9.Results It was observed that mortality from the three major causes of (1) infectious,maternal and childhood diseases,(2) chronic non-communicable diseases,and (3) injury and poisoning were 17.7,298.2 and 26.0 per 100 000,respectively.The largest decrease in death rate over the 21-year study-period was from infectious,maternal and childhood diseases (62.5%).The highest mortality rate was ischemic heart diseases (37.0%).The largest increase in mortality rate was lung cancer (46.9%).Conclusions Mortality rate of Macao residents progressively decreased,but the constituent ratio of death from chronic non-communicable diseases was increasing.The mortality rate of lung cancer was clearly ascending,so emphasis should be put on tertiary prevention in future.

  12. Changes in vegetation and soil seed bank of meadow after waterlogging caused by Castor fiber

    Directory of Open Access Journals (Sweden)

    Magdalena Franczak


    Full Text Available Soil waterlogging is among abiotic stresses that influence species composition and productivity in numerous plant communities. The aim of the study was to find answer to the question of how waterlogging caused by beavers’ activity induces quantitative and qualitative changes of vegetation and soil seed bank levels of variable-moist meadows. An immediate effect of the waterlogging at the level of vegetation was the decline in species richness and a decrease in the values of the biodiversity index. Water stress inhibited growth and development of plants already present and, primarily, impeded recruitment of new individuals of species characteristic of variable-moist meadows, e.g. Cirsium rivulare, Filipendula ulmaria and Lythrum salicaria, which were replaced by Carex acutiformis. Prolonged waterlogging did not induce equally substantial changes in the soil seed bank as in the vegetation. Both in the waterlogged and control patches, slightly decreased species richness and biodiversity index were recorded. After waterlogging withdrawal, the reserves of the soil seed bank were slightly higher than the initial values. The differences were not statistically significant. In the waterlogged patch, the qualitative floristic similarity between taxa identified in the soil seed bank and vegetation cover declined, which was evidenced by the value of Jaccard’s index decreasing from 0.46 to 0.36. A reverse relationship was found in control patch, where the value of the similarity index slightly increased from 0.41 to 0.48.

  13. Risk for colorectal cancer in ulcerative colitis: changes, causes and management strategies. (United States)

    Lakatos, Peter-Laszlo; Lakatos, Laszlo


    The risk of colorectal cancer for any patient with ulcerative colitis is known to be elevated, and is estimated to be 2% after 10 years, 8% after 20 years and 18% after 30 years of disease. Risk factors for cancer include extent and duration of ulcerative colitis, primary sclerosing cholangitis, a family history of sporadic colorectal cancer, severity of histologic bowel inflammation, and in some studies, young age at onset of colitis. In this review, the authors discuss recent epidemiological trends and causes for the observed changes. Population-based studies published within the past 5 years suggest that this risk has decreased over time, despite the low frequency of colectomies. The crude annual incidence rate of colorectal cancer in ulcerative colitis ranges from approximately 0.06% to 0.16% with a relative risk of 1.0-2.75. The exact mechanism for this change is unknown; it may partly be explained by the more widespread use of maintenance therapy and surveillance colonoscopy.

  14. Changes in Snow Albedo Resulting from Snow Darkening Caused by Black Carbon (United States)

    Engels, J.; Kloster, S.; Bourgeois, Q.


    potential climate impact will be analyzed in terms of the radiative forcing caused by the snow darkening induced changes in surface albedo.

  15. Age dependent white matter lesions and brain volume changes in healthy volunteers

    DEFF Research Database (Denmark)

    Christiansen, P; Larsson, H B; Thomsen, C


    The brain of 142 healthy volunteers aged 21 to 80 years were investigated using MR imaging. The number and size of the white matter hyperintensity lesions (WMHL) in the cerebral hemispheres were determined. Furthermore, the volume of the cerebral hemispheres and of the lateral ventricles...... was measured. An almost linear increase in the number of volunteers with WMHL was seen with aging for males and females. With aging a significant decrease in the volume of the cerebral hemispheres was found for males, and a significant increase in the volume of the lateral ventricles was seen for both males...... and females. Our results suggest that with aging central atrophy increases more (relatively) than cortical atrophy. No correlation was found between the decreasing volume of the cerebral hemispheres and the increasing number and size of WMHL, nor between the increasing volume of the lateral ventricles...

  16. Change Matters: Critical Essays on Moving Social Justice Research from Theory to Policy. Critical Qualitative Research. Volume 1 (United States)

    Miller, S. J., Ed.; Kirkland, David E., Ed.


    "Change Matters," written by leading scholars committed to social justice in English education, provides researchers, university instructors, and preservice and inservice teachers with a framework that pivots social justice toward policy. The chapters in this volume detail rationales about generating social justice theory in what Freire calls "the…

  17. Assessment and forecast of changes of reservoir volumes due to thermal settling in permafrost areas of Russia

    Institute of Scientific and Technical Information of China (English)

    Ilja S.Sobol; Stanislav V.Sobol


    This paper presents the results of data analyses and assessments of field and theoretical researches on reservoir bed relief transformation due to thermal settling in the permafrost regions of Russia. The resulting changes (increases) of the total volumes of large and small reservoirs are quantified, of which information will be of great use in future reservoir design and exploitation.

  18. Double knockout of carbonic anhydrase II (CAII) and Na(+)-Cl(-) cotransporter (NCC) causes salt wasting and volume depletion. (United States)

    Xu, Jie; Barone, Sharon; Brooks, Mary-Beth; Soleimani, Manoocher


    The thiazide-sensitive Na(+)-Cl(-) cotransporter NCC and the Cl(-)/HCO3(-)exchanger pendrin are expressed on apical membranes of distal cortical nephron segments and mediate salt absorption, with pendrin working in tandem with the epithelial Na(+) channel (ENaC) and the Na(+)-dependent chloride/bicarbonate exchanger (NDCBE), whereas NCC is working by itself. A recent study showed that NCC and pendrin compensate for loss of each other under basal conditions, therefore masking the role that each plays in salt reabsorption. Carbonic anhydrase II (CAII, CA2 or CAR2) plays an important role in acid-base transport and salt reabsorption in the proximal convoluted tubule and acid-base transport in the collecting duct. Animals with CAII deletion show remodeling of intercalated cells along with the downregulation of pendrin. NCC KO mice on the other hand show significant upregulation of pendrin and ENaC. Neither model shows any significant salt wasting under baseline conditions. We hypothesized that the up-regulation of pendrin is essential for the prevention of salt wasting in NCC KO mice. To test this hypothesis, we generated NCC/CAII double KO (dKO) mice by crossing mice with single deletion of NCC and CAII. The NCC/CAII dKO mice displayed significant downregulation of pendrin, along with polyuria and salt wasting. As a result, the dKO mice developed volume depletion, which was associated with the inability to concentrate urine. We conclude that the upregulation of pendrin is essential for the prevention of salt and water wasting in NCC deficient animals and its downregulation or inactivation will result in salt wasting, impaired water conservation and volume depletion in the setting of NCC inactivation or inhibition. © 2014 S. Karger AG, Basel.

  19. Climatic and ecological future of the Amazon: likelihood and causes of change

    Directory of Open Access Journals (Sweden)

    B. Cook


    Full Text Available Some recent climate modeling results suggested a possible dieback of the Amazon rainforest under future climate change, a prediction that raised considerable interest as well as controversy. To determine the likelihood and causes of such changes, we analyzed the output of 15 models from the Intergovernmental Panel on Climate Change Fourth Assessment Report (IPCC/AR4 and a dynamic vegetation model VEGAS driven by these climate output. Our results suggest that the core of the Amazon rainforest should remain largely stable as rainfall is projected to increase in nearly all models. However, the periphery, notably the southern edge of the Amazon and further south in central Brazil, are in danger of drying out, driven by two main processes. Firstly, a decline in precipitation of 22% in the southern Amazon's dry season (May–September reduces soil moisture, despite an increase in precipitation during the wet season, due to nonlinear responses in hydrology and ecosystem dynamics. Two dynamical mechanisms may explain the lower dry season rainfall: (1 a general subtropical drying under global warming when the dry season southern Amazon is under the control of the subtropical high pressure; (2 a stronger north-south tropical Atlantic sea surface temperature gradient, and to lesser degree a warmer eastern equatorial Pacific. Secondly, evaporation demand will increase due to the general warming, further reducing soil moisture. In terms of ecosystem response, higher maintenance cost and reduced productivity under warming may also have additional adverse impact. The drying corresponds to a lengthening of the dry season by 11 days. As a consequence, the median of the models projects a reduction of 20% in vegetation carbon stock in the southern Amazon, central Brazil, and parts of the Andean Mountains. Further, VEGAS predicts enhancement of fire risk by 10–15%. The increase in fire is primarily due to the reduction in soil moisture, and the decrease in dry

  20. Evaluating the effect of hydrocephalus cause on the manner of changes in the effective parameters and clinical symptoms of the disease. (United States)

    Gholampour, Seifollah; Fatouraee, Nasser; Seddighi, Amir Saeed; Seddighi, Afsoun


    In the present study, the heads of 11 normal subjects and 21 patients affected by hydrocephalus due to three different causes were simulated using fluid-structure interaction (FSI). To validate the results, the calculated diagram of CSF velocity in aqueduct of Sylvius (AS) was compared with the similar velocity diagram measured using Cine PC-MRI for the same subject. After ensuring the agreement of results, other outputs such as CSF pressure were calculated non-invasively using FSI. The intracranial pressure and CSF pressure in AS and behind the optic nerve sheath were in patients 5-5.3 times the value in normal subjects and the ventricular system volume in patients was 10.2-11.1 times the value in normal subjects. However, the difference between the coefficient of variation and the maximum value of pressure and volume in different types of hydrocephalus was small. Furthermore, the difference between CSF stroke volumes in various types of hydrocephalus patients was less than 4.4%. Results showed that the intensity of clinical symptoms was similar in patients with similar CSF pressure and the cause of the hydrocephalus disease didn't have any significant effect on the intensity of patients' clinical symptoms and the manner of changes in effective parameters on disease. It was also found that the relation of CSF pressure and volume was 16.7% greater in patients with non-communicating hydrocephalus than in patients with communicating hydrocephalus. These results enhance the insight into hydrocephalus bio-mechanism and can help to choose the proper treatment method for hydrocephalus patients.

  1. Iodine fortification may influence the age-related change in thyroid volume

    DEFF Research Database (Denmark)

    Motavaf, Anne Krejbjerg; Pedersen, Inge Bülow; Bjergved, Lena


    Improving PV system reliability and reducing maintenance and operating costs have become important factors in increasing the competitiveness of PV. Addressing these issues requires diagnostic methods that can detect and identify the occurrence and cause of power loss in the PV system, be it exter......Improving PV system reliability and reducing maintenance and operating costs have become important factors in increasing the competitiveness of PV. Addressing these issues requires diagnostic methods that can detect and identify the occurrence and cause of power loss in the PV system......, be it external, such as shading or soiling, or degradation or failure of the PV modules and balance-of-system components. This allows for performing preventive and/or reparative maintenance, thus minimizing further losses and costs. This article proposes a complete diagnostic method for detecting shading......, increased series-resistance losses, and potential-induced degradation of the PV generator by analysing changes its current-voltage characteristic curve. The diagnostic method is based on parameters that can be easily calculated from the shape of the current-voltage curve, making it machine-analysis friendly...

  2. Approximations for Estimating Change in Life Expectancy Attributable to Air Pollution in Relation to Multiple Causes of Death Using a Cause Modified Life Table. (United States)

    Stieb, David M; Judek, Stan; Brand, Kevin; Burnett, Richard T; Shin, Hwashin H


    There is considerable debate as to the most appropriate metric for characterizing the mortality impacts of air pollution. Life expectancy has been advocated as an informative measure. Although the life-table calculus is relatively straightforward, it becomes increasingly cumbersome when repeated over large numbers of geographic areas and for multiple causes of death. Two simplifying assumptions were evaluated: linearity of the relation between excess rate ratio and change in life expectancy, and additivity of cause-specific life-table calculations. We employed excess rate ratios linking PM2.5 and mortality from cerebrovascular disease, chronic obstructive pulmonary disease, ischemic heart disease, and lung cancer derived from a meta-analysis of worldwide cohort studies. As a sensitivity analysis, we employed an integrated exposure response function based on the observed risk of PM2.5 over a wide range of concentrations from ambient exposure, indoor exposure, second-hand smoke, and personal smoking. Impacts were estimated in relation to a change in PM2.5 from 19.5 μg/m(3) estimated for Toronto to an estimated natural background concentration of 1.8 μg/m(3) . Estimated changes in life expectancy varied linearly with excess rate ratios, but at higher values the relationship was more accurately represented as a nonlinear function. Changes in life expectancy attributed to specific causes of death were additive with maximum error of 10%. Results were sensitive to assumptions about the air pollution concentration below which effects on mortality were not quantified. We have demonstrated valid approximations comprising expression of change in life expectancy as a function of excess mortality and summation across multiple causes of death.

  3. Longitudinal volume changes of the pituitary gland in patients with schizotypal disorder and first-episode schizophrenia. (United States)

    Takahashi, Tsutomu; Zhou, Shi-Yu; Nakamura, Kazue; Tanino, Ryoichiro; Furuichi, Atsushi; Kido, Mikio; Kawasaki, Yasuhiro; Noguchi, Kyo; Seto, Hikaru; Kurachi, Masayoshi; Suzuki, Michio


    An enlarged volume of the pituitary gland has been reported in the schizophrenia spectrum, possibly reflecting the hypothalamic-pituitary-adrenal (HPA) hyperactivity. However, it remains largely unknown whether the pituitary size longitudinally changes in the course of the spectrum disorders. In the present study, longitudinal magnetic resonance imaging (MRI) data were obtained from 18 patients with first-episode schizophrenia, 13 patients with schizotypal disorder, and 20 healthy controls. The pituitary volume was measured at baseline and follow-up (mean, 2.7 years) scans and was compared across groups. The pituitary volume was larger in the schizophrenia patients than controls at baseline, and both patient groups had significantly larger pituitary volume than controls at follow-up. In a longitudinal comparison, both schizophrenia (3.6%/year) and schizotypal (2.7%/year) patients showed significant pituitary enlargement compared with controls (-1.8%/year). In the schizophrenia patients, greater pituitary enlargement over time was associated with less improvement of delusions and higher scores for thought disorders at the follow-up. These findings suggest that the pituitary gland exhibits ongoing volume changes during the early course of the schizophrenia spectrum as a possible marker of state-related impairments. Copyright © 2010 Elsevier Inc. All rights reserved.

  4. Digital surgical templates for managing high-energy zygomaticomaxillary complex injuries associated with orbital volume change: a quantitative assessment. (United States)

    Liu, Xiang-Zhen; Shu, Da-Long; Ran, Wei; Guo, Bing; Liao, Xin


    This study sought to introduce 3-dimensional (3D) virtual surgical planning and digital rapid-prototyping templates for zygomaticomaxillary complex (ZMC) injuries associated with orbital volume change and to evaluate the surgical outcomes quantitatively. Eight patients who underwent open reduction and fixation for a ZMC injury with orbital volume change were studied. Computed tomographic (CT) scan of the zygomaticomaxillary area was performed before the operation in each case. Scanned data were converted into 3D models using Mimics software (Materialise, Brussels, Belgium) for surgical designs. Virtual surgical reductions and correlated guiding templates were designed using Mimics and Magics software (Materialise). The operations were performed with the help of prefabricated templates to reduce the fractures. A postoperative CT scan of each patient was obtained within 2 weeks after surgery, and quantitative measurements were made to assess the surgical outcomes. Preoperative volumes of the bilateral orbits were compared, and concordance with postoperative volumes of the bilateral orbits was assessed. Twenty-one pairs of distances from 7 marker points to 3 reference planes were measured to assess postoperative facial symmetry. Volumes of the injured orbits were significantly different from volumes of the uninjured orbits preoperatively (P .05). In addition, 19 of the 21 pairs of bilateral distances showed no significant difference postoperatively (P > .05). Quantitative assessment showed that digitally designed, rapid-prototyping templates for ZMC fractures have a positive impact on restoring facial symmetry and concordance of bilateral orbital volumes. Copyright © 2013 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  5. Marine reserves reestablish lost predatory interactions and cause community changes in rocky reefs. (United States)

    Guidetti, Paolo


    In the last decades, marine reserves have dramatically increased in number worldwide. Here I examined the potential of no-take marine reserves to reestablish lost predatory interactions and, in turn, cause community-wide changes in Mediterranean rocky reefs. Protected locations supported higher density and size of the most effective fish preying on sea urchins (the sea breams Diplodus sargus and D. vulgaris) than unprotected locations. Density of sea urchins (Paracentrotus lividus and Arbacia lixula) was lower at protected than at unprotected locations. Size structure of P. lividus was bimodal (a symptom of predation on medium-sized urchins) only at the protected locations. Coralline barrens were less extended at protected than at unprotected locations, whereas turf-forming and erect-branched algae showed an opposite pattern. Erect-unbranched and erect-calcified algae and conspicuous zoobenthic organisms did not show any pattern related to protection. Tethering experiments showed that predation impact on urchins was (1) higher at protected than at unprotected locations, (2) higher on P. lividus than on A. lixula, and (3) higher on medium-sized (2-3.5 cm test diameter) than large-sized (>3.5 cm) urchins. Sea urchins preyed on by fish in natural conditions were smaller at unprotected than at protected locations. The analysis of sea urchin remains found in Diplodus fish stomachs revealed that medium-sized P. lividus were the most frequently preyed upon urchins and that size range of consumed sea urchins expanded with increasing size of Diplodus fish. These results suggest that (1) depletion and size reduction of predatory fish caused by fishing alter patterns of predation on sea urchins, and that (2) fishing bans (e.g., within no-take marine reserves) may reestablish lost interactions among strongly interactive species in temperate rocky reefs with potential community-wide effects.

  6. Uncertainties in the global temperature change caused by carbon release from permafrost thawing

    Directory of Open Access Journals (Sweden)

    E. J. Burke


    Full Text Available Under climate change thawing permafrost will cause old carbon which is currently frozen and inert to become vulnerable to decomposition and release into the climate system. This paper develops a simple framework for estimating the impact of this permafrost carbon release on the global mean temperature (P-GMT. The analysis is based on simulations made with the Hadley Centre climate model (HadGEM2-ES for a range of representative CO2 concentration pathways. Results using the high concentration pathway (RCP 8.5 suggest that by 2100 the annual methane (CH4 emission rate is 2–59 Tg CH4 yr−1 and 50–270 Pg C has been released as CO2 with an associated P-GMT of 0.08–0.36 °C (all 5th–95th percentile ranges. P-GMT is considerably lower – between 0.02 and 0.11 °C – for the low concentration pathway (RCP2.6. The uncertainty in climate model scenario causes about 50% of the spread in P-GMT by the end of the 21st century. The distribution of soil carbon, in particular how it varies with depth, contributes to about half of the remaining spread, with quality of soil carbon and decomposition processes contributing a further quarter each. These latter uncertainties could be reduced through additional observations. Over the next 20–30 yr, whilst scenario uncertainty is small, improving our knowledge of the quality of soil carbon will contribute significantly to reducing the spread in the, albeit relatively small, P-GMT.

  7. Characteristic of Secondary Flow Caused by Local Density Change in Standing Acoustic Fields (United States)

    Tonsho, Kazuyuki; Hirosawa, Takuya; Kusakawa, Hiroshi; Kuwahara, Takuo; Tanabe, Mitsuaki

    Secondary flow is a flow which is caused by the interference between standing acoustic fields and local density change. The behavior of the secondary flow depends on the location of the given local density change in the standing acoustic fields. When the density change is given at the middle of a velocity node and the neighboring velocity anti-node (middle point) or when it is given at the velocity anti-node in standing acoustic fields, the secondary flow shows particular behavior. Characteristic of the secondary flow at the two positions was predicted by numerical simulations. It was examined from these simulations whether the driving mechanism of the flow can be explained by the kind of acoustic radiation force that has been proposed so far. The predicted secondary flow was verified by experiments. For both the simulations and experiments, the standing acoustic fields generated in a cylinder are employed. In the experiments, the acoustic fields are generated by two loud speakers that are vibrated in same phase in a chamber. The employed resonance frequency is about 1000 Hz. The chamber is filled with air of room temperature and atmospheric pressure. In the numerical simulations and experiments, the local density change is given by heating or cooling. Because the secondary flow is influenced by buoyancy, the numerical simulations were done without taking gravity force into account and a part of the experiments were done by the microgravity condition using a drop tower. As a result of the simulations, at the middle point, the heated air was blown toward the node and the cooled air was blown toward the anti-node. It is clarified that the secondary flow is driven by the expected kind of acoustic radiation force. At the anti-node, both the heated and cooled air expands perpendicular to the traveling direction of the sound wave. The driving mechanism of the secondary flow can not be explained by the acoustic radiation force, and a detailed analysis is done. Through the

  8. Thermal Volume Changes and Creep in the Callovo-Oxfordian Claystone (United States)

    Belmokhtar, Malik; Delage, Pierre; Ghabezloo, Siavash; Conil, Nathalie


    The Callovo-Oxfordian (COx) claystone is considered as a potential host rock for high-level radioactive waste disposal at great depth in France. Given the exothermic nature of radioactive wastes, a temperature elevation planned to be smaller than 100 °C will affect the host rock around the disposal cells. To gain better understanding of the thermal volumetric response of the COx claystone, a new thermal isotropic compression cell was developed with particular attention devoted to monitoring axial and radial strains. To do so, a high-precision LVDTs system ensuring direct contact between the LVDT stem and the claystone sample through the membrane was developed. A short drainage length (10 mm) was also ensured so as to allow full saturation of the sample under stress conditions close to in situ, and fully drained conditions during compression. High-precision strain monitoring allowed to observe a volumetric creep under stress conditions close to in situ. A drained heating test under constant stress carried out afterwards up to 80 °C exhibited a thermoelastic expansion up to a temperature of 48 °C, followed by thermoplastic contraction at higher temperature. Creep volume changes, that appeared to be enhanced by temperature, were modelled by using a simple Kelvin-Voigt model, so as to estimate the instantaneous response of the COx claystone and to determine its thermal expansion coefficient. The temperature at which the transition between thermal expansion and contraction appeared is close to the maximum burial temperature of the Callovo-Oxfordian claystone, estimated at 50 °C. This is in agreement with what has been already observed on the Opalinus Clay by Monfared et al. (2012) that was interpreted as a thermal hardening phenomenon, showing that the material kept the memory of the highest temperature supported during its geological history.

  9. Changes in causes of death and mortality rates among children in Greenland from 1987 - 91 to 1992 - 99

    DEFF Research Database (Denmark)

    Aaen-Larsen, Birger; Bjerregaard, Peter


    This study analysed the spontaneous trends in mortality among children in Greenland from 1987 - 91 to 1992 - 99 and describes the changes in the causes of death, mortality rates, and variation between regions....


    Directory of Open Access Journals (Sweden)

    Zubrovskaya O. M.


    Full Text Available Arboreal plants intensively accumulate heavy metals, resulting in a corresponding revocation level of physiological processes. The lipid components operate an important role in the formation of plant resistance. Therefore, it was very important to determine the characteristics of lipid peroxidation flow in leaves of arboreal plants, and changes in the composition of cuticle surface lipids at different levels of heavy metal accumulation. Research objects were Populus italica (Du Roi Moench and Betula pendula Roth. of second age group, growing on the industrial site РJSC ‘Kryvyi Rig Factory of minium’ (with strong contamination and in the arboretum of Kryvyi Rig Botanic Garden, National Academy of Science of Ukraine (conventional control. Leaves were taken from the middle of the crown southwest exposure in phase of leaf full separation and 5-10 day of phase finishing point of their growth. It was shown that P. italica maximally accumulated zinc, content of which was increased in the phase of leaf full separation and on 5-10 day of phase of leaf growth finishing point relative to the control to 12,6 and 23 times respectively. The accumulation level of heavy metals was typically less significant for assimilation organs of B. pendula compared to P. italica. Thus, the content of zinc and lead in the leaves during the study increased only in 2 times towards control. The leaves of B. pendula, unlike P. italica, more intensively accumulated cadmium in the phase of leaf full separation and on 5-10 day of phase finishing point of their growth (it was 6 and 15 times higher relative to control respectively. It was obviously connected to the fact that the surface texture of poplar leaves may cause intense sticking of dust particles containing heavy metals and penetration into the leaves. The effect of heavy metals in both phases of leaf morphogenesis caused an increase in lipid peroxidation by 40-52% for P. italica and almost by 3 times for B. pendula

  11. Causes of macrocytic anemia among 628 patients: mean corpuscular volumes of 114 and 130 fL as critical markers for categorization. (United States)

    Takahashi, Natsuko; Kameoka, Junichi; Takahashi, Naoto; Tamai, Yoshiko; Murai, Kazunori; Honma, Riko; Noji, Hideyoshi; Yokoyama, Hisayuki; Tomiya, Yasuo; Kato, Yuichi; Ishizawa, Kenichi; Ito, Shigeki; Ishida, Yoji; Sawada, Kenichi; Harigae, Hideo


    There have been no studies on the distribution of causes of macrocytic anemia with respect to mean corpuscular volume (MCV) cutoff values. We retrospectively investigated the causes of macrocytic anemia (MCV ≥100 fL) among 628 patients who visited the outpatient hematology clinic in Tohoku University Hospital. To ensure data validity, we also analyzed data from 307 patients in eight other hospitals in the Tohoku district. The leading causes of macrocytic anemia (number of patients, %) were myelodysplastic syndromes (121, 19.3 %), suspected bone marrow failure syndromes (BMF; 74, 11.8 %), aplastic anemia (51, 8.1 %), plasma cell dyscrasia (45, 7.2 %), and vitamin B12 deficiency (40, 6.4 %) in Tohoku University Hospital. We made three primary findings as follows. First, the most common cause of macrocytic anemia is BMF. Second, lymphoid and solid malignancies are also common causes of macrocytosis. Third, macrocytic anemia may be classified into three groups: Group 1 (megaloblastic anemia and medications), which can exceed MCV 130 fL; Group 2 (alcoholism/liver disease, BMF, myeloid malignancy, and hemolytic anemia), which can exceed MCV 114 fL; and Group 3 (lymphoid malignancy, chronic renal failure, hypothyroidism, and solid tumors), which does not exceed MCV 114 fL. These conclusions were supported by the results from eight other hospitals.

  12. Geomorphic change caused by outburst floods and debris flows at Mount Rainier, Washington, with emphasis on Tahoma Creek valley (United States)

    Walder, J.S.; Driedger, C.L.


    Debris flows have caused rapid geomorphic change in several glacierized drainages on Mount Rainier, Washington. Nearly all of these flows began as glacial outburst floods, then transformed to debris flows by incorporating large masses of sediment in channel reaches where streams have incised proglacial sediments and stagnant glacier ice. This stagnant ice is a relic of advanced glacier positions achieved during the mid-nineteenth century Little Ice Age maximum and the readvance of the 1960's and 1970's. Debris flows have been especially important agents of geomorphic change along Tahoma Creek, which drains South Tahoma Glacier. Debris flows in Tahoma Creek valley have transported downstream about 107 m3 Of sediment since 1967, causing substantial aggradation and damage to roads and facilities in Mount Rainier National Park. The average denudation rate in the upper part of the Tahoma Creek drainage basin in the same period has been extraordinarily high: more than 20 millimeters per year, a value exceeded only rarely in basins affected by debris flows. However, little or none of this sediment has yet passed out of the Tahoma Creek drainage basin. Outburst floods from South Tahoma Glacier form by release of subglacially stored water. The volume of stored water discharged during a typical outburst flood would form a layer several tens of millimeters thick over the bed of the entire glacier, though it is more likely that large linked cavities account for most of the storage. Statistical analysis shows that outburst floods usually occur during periods of atypically hot or rainy weather in summer or early autumn, and that the probability of an outburst increases with temperature (a proxy measure of ablation rate) or rainfall rate. On the basis of these results, we suggest that outburst floods are triggered when rapid input of water to the glacier bed causes transient increase in water pressure, thereby destabilizing the linked-cavity system. The probabilistic nature of

  13. Assessment of bronchodilator response through changes in lung volumes in chronic airflow obstruction

    Directory of Open Access Journals (Sweden)

    J.B. Figueroa-Casas


    Full Text Available Although FEV1 improvement is routinely used to define bronchodilator (BD response, it correlates poorly with clinical effects. Changes in lung volumes (LV have shown better correlation with exercise tolerance and might be more sensitive to detect BD effects. We assessed the additional contribution of measuring LV before and after BD to detect acute improvement in lung function not demonstrated by FEV1, and the influence of the response criteria selected on this contribution. We analyzed 98 spirometries and plethismographies performed pre and post BD in patients with airflow obstruction (FEV1/FVC 10% of baseline (D>5 anD>15% were also analyzed. FEV1 identified as responders 32% of patients. Greater proportions were uncovered by slow vital capacity (51%, p5 anD>15%. Mean change and proportions of responders for each LV varied significantly (pSi bien el aumento del VEF1 es habitualmente utilizado para definir respuesta a broncodilatadores (BD, su correlación con efectos clínicos es pobre. Los cambios en volúmenes pulmonares (VP han demostrado mejor correlación con tolerancia al ejercicio y podrían ser más sensibles para detectar efectos de los BD. Nosotros evaluamos la contribución adicional de medir VP antes y después de BD para detectar mejoría funcional aguda no demostrada por cambios del VEF1, y la influencia del criterio de respuesta seleccionado en esta contribución. Se analizaron 98 espirometrías y pletismografías realizadas pre y post BD en pacientes con obstrucción al flujo aéreo (VEF1/CVF 10% del basal (D>5 y 15% fueron también analizados. El VEF1 identificó como respondedores a 32% de los pacientes. Proporciones mayores fueron identificadas por capacidad vital lenta (51%, p5 y 15%. El cambio promedio y las proporciones de respondedores para cada VP variaron significativamente (p<0.05 según que el cambio fuese expresado como porcentaje del basal o del valor predicho. Una proporción considerable de pacientes con obstrucci

  14. Thinking about Global Warming: Effect of Policy-Related Documents and Prompts on Learning about Causes of Climate Change (United States)

    Blaum, Dylan; Griffin, Thomas D.; Wiley, Jennifer; Britt, M. Anne


    We examined students' understanding of the causes of a scientific phenomenon from a multiple-document-inquiry unit. Students read several documents that each described causal factors that could be integrated to address the given writing task of explaining the causes of change in average global temperature. We manipulated whether the document set…

  15. Alteração no volume do fluido gengival durante a retração de caninos superiores Change in the gingival fluid volume during maxillary canine retraction

    Directory of Open Access Journals (Sweden)

    Jonas Capelli Jr.


    Full Text Available INTRODUÇÃO: na análise da teoria da pressão/tensão do movimento dentário, a aplicação de uma força ortodôntica causa um deslocamento gradual dos fluidos do ligamento periodontal, acompanhado pela distorção das células e da matriz extracelular. OBJETIVOS: avaliar a quantidade de volume do fluido gengival (FG nas faces mesiais e distais dos caninos superiores, de 14 pacientes (3 homens e 11 mulheres submetidos a movimentação ortodôntica. MÉTODOS: o fluido foi coletado com tira de papel absorvente padrão (Periopaper® e seu volume foi determinado por meio da utilização do medidor Periotron®, em sete tempos distintos (dia -7, dia 0, 1 hora, 24 horas, 14 dias, 21 dias e 80 dias. O teste Friedman foi usado para comparar os dados obtidos (p INTRODUCTION: In the analysis of the pressure-tension theory of tooth movement, the application of an orthodontic force causes gradual displacement of fluids of the periodontal ligament, followed by distortion of the cells and extracellular matrix. OBJECTIVES: This study evaluated the gingival fluid volume on the mesial and distal aspects of the maxillary canines of 14 patients (3 males and 11 females submitted to orthodontic movement. METHODS: The fluid was collected using standard absorbent paper strips (Periopaper™ and the fluid volume was determined using the instrument Periotron™ at seven different periods (day -7, day 0, 1 hour, 24 hours, 14 days, 21 days, 80 days. The Friedman test was applied to compare the data achieved (p < 0.01 and p < 0.05. RESULTS: The results revealed a significant change in the gingival fluid volume with time on both the pressure side (p < 0.001 and the tension side (p < 0.01. On the pressure side, the gingival fluid volume was significantly lower at the periods 0 (p < 0.01 and 24hs (p < 0.001 compared to the period 80 days.

  16. Causes of Greenland temperature variability over the past 4000 yr: implications for northern hemispheric temperature change

    Directory of Open Access Journals (Sweden)

    T. Kobashi


    Full Text Available A new Greenland temperature record reconstructed from argon and nitrogen isotopes from trapped air in a GISP2 ice core, provides high-resolution (<20 yr and precise annual average temperature estimates for the past 4000 yr. Due to tight age-controls and abundant paleoclimatic information from the ice core, the temperature record provides an exceptional opportunity to investigate the late Holocene climate in a multi-decadal to millennial time scale. To investigate causes of Greenland temperature variability over the past 4000 yr, we calculated high latitude (70–80° N temperature change using a one-dimensional energy balance model with reconstructed climate forcings including orbital, solar, volcanic, and greenhouse gas forcings. Greenland temperature was calculated from the high latitude temperature, considering Greenland's negative temperature responses to solar variability due to associated changes in atmospheric and oceanic circulations. The calculated Greenland temperature was significantly correlated with the ice-core-derived Greenland temperatures with the 97% confidence level. Therefore, the past variability of climate forcings can explain at least 10% of the multi-decadal to millennial variability in Greenland temperature over the past 4000 yr. An average temperature trend for the Northern Hemisphere (NH over the past 4000 yr was also inferred from the ice-core derived Greenland temperatures. Lines of evidence indicate that the current decadal average temperature of NH is likely warmer than at any time over the past 4000 yr. Sequential cooling events starting around 800 B.C.E. (the 2.8 ka event, which were induced by several large volcanic eruptions as well as low solar activity, had similar magnitude with the Little Ice Age cooling.

  17. Effects of fluorotherapy on oral changes caused by a vegan diet. (United States)

    Zotti, F; Laffranchi, L; Fontana, P; Dalessandri, D; Bonetti, S


    The aim of this paper was to investigate the effects of fluorotherapy on the oral health of subjects who had been following a vegan diet (lacking in meat and animal derivatives) for a long period of time (at least 1 year and 6 months). A preliminary study (t0) evaluated 50 subjects, all from northern Italy and aged 24-60 years (28 male and 22 female) who had been following a vegan diet for a minimum of 18 months to a maximum of 20 years, and compared them with a control group of 50 individuals following a Mediterranean diet. All vegan subjects showed oral changes such as white spots, lesions invisible to the naked eye and decreased salivary pH values (~5-6). In a second study (t1), the 50 vegan subjects were randomly divided into two subgroups of 25. Subgroup SG1 underwent fluorotherapy with sodium fluoride (Elmex fluoride gel® 1.25%) administered once daily for 1 year. Subgroup SG2 served as controls and did not receive fluorotherapy. The following parameters were recorded before the start of fluorotherapy and again after 1 year: salivary pH; Decayed, Missing, Filled teeth Index; presence and location of white spots and lesions not visible to the naked eye; Plaque Index, and Gingival Index. In SG1, larger lesions became smaller in diameter and small lesions disappeared, a statistically significant improvement compared with SG2, despite the persistence of restricted eating habits and the oral hygiene conditions being similar to those at t0. Salivary pH showed no significant change in either subgroup. Daily application of a topical 1.25% fluoride gel is effective in reducing the incidence of white spot lesions caused by a vegan diet.

  18. Microstructural changes of cows’ uterus in an infection caused by Haemophilus somnus

    Directory of Open Access Journals (Sweden)

    Danka Šťastná


    Full Text Available The reproductive form of Haemophilic infection caused by a microorganism Histophilus somni (Haemophilus somnus is in our conditions practically unknown and undiscovered disease of cow reproductive organs. The aim of this work was based on experimental work to provide a comprehensive view on the patho-histological and submicroscopic changes in the uterus of 60 cows, serological positive, crossbreeds Slovenske strakate x Holstein, aged 3.5 . 4.5 years, serological positive, which were up to 90 days after the parturition sterile. After the hormonal control of the oestrus cycle (PGF2ƒż-Oestrophan SPOFA the cows were inseminated and the non-gravid cows later killed. The reproductive organs of killed animals were pathologically . anatomically dissected with following histological and sub-microscopic study of uterus and cervix tissue. At the beginning of the experiment no clinical changes of the reproductive organs of group 1 animals with the titer of antibodies 1:25-100 were diagnosed and in group 3 with the titer 1:25. At an examination before killing were examined endometritis (EM of grade II. and vaginitis with vestibulitis in these groups. At the rest of animals appeared in every level of the titer of antibodies of EM II. and EM III. EM I. were not clinically diagnosed. Dissecting examination determined EM catarrhalis and cervicis catarrhalis in all groups. The histological examination pointed to EM catarrhalis chronica, EM interstitialis chronica, EM fibrousis and cervicis catarrhalis chronica. The leucocytes gained from a uterus lavage were in a comparison with stroma leucocytes mostly polynuclear (neutrophils and in smaller amount small forms of lymfocytes. At long-term sterility of cows, because of possible H. somnus infection, we regard as priority the serodiagnostics at which is taken into consideration any level of the titer of antibodies.

  19. Long-term oil contamination causes similar changes in microbial communities of two distinct soils. (United States)

    Liao, Jingqiu; Wang, Jie; Jiang, Dalin; Wang, Michael Cai; Huang, Yi


    Since total petroleum hydrocarbons (TPH) are toxic and persistent in environments, studying the impact of oil contamination on microbial communities in different soils is vital to oil production engineering, effective soil management and pollution control. This study analyzed the impact of oil contamination on the structure, activity and function in carbon metabolism of microbial communities of Chernozem soil from Daqing oil field and Cinnamon soil from Huabei oil field through both culture-dependent techniques and a culture-independent technique-pyrosequencing. Results revealed that pristine microbial communities in these two soils presented disparate patterns, where Cinnamon soil showed higher abundance of alkane, (polycyclic aromatic hydrocarbons) PAHs and TPH degraders, number of cultivable microbes, bacterial richness, bacterial biodiversity, and stronger microbial activity and function in carbon metabolism than Chernozem soil. It suggested that complicated properties of microbes and soils resulted in the difference in soil microbial patterns. However, the changes of microbial communities caused by oil contamination were similar in respect of two dominant phenomena. Firstly, the microbial community structures were greatly changed, with higher abundance, higher bacterial biodiversity, occurrence of Candidate_division_BRC1 and TAO6, disappearance of BD1-5 and Candidate_division_OD1, dominance of Streptomyces, higher percentage of hydrocarbon-degrading groups, and lower percentage of nitrogen-transforming groups. Secondly, microbial activity and function in carbon metabolism were significantly enhanced. Based on the characteristics of microbial communities in the two soils, appropriate strategy for in situ bioremediation was provided for each oil field. This research underscored the usefulness of combination of culture-dependent techniques and next-generation sequencing techniques both to unravel the microbial patterns and understand the ecological impact of

  20. Evaluation of postoperative change in lung volume in adolescent idiopathic scoliosis: Measured by computed tomography

    Directory of Open Access Journals (Sweden)

    Dong Kyu Lee


    Conclusion: Patients with AIS who have preoperative reduced lung volumes or lung functions can achieve further increased lung volume after surgical correction. Pulmonary complications during perioperative period were mostly treated with proper management without severe sequale. Therefore, although surgery for AIS is considered to be a high risk procedure, we can recommend to correct spine deformity in patients with severe AIS in order to improve lung function and long term prognosis.

  1. Detection,Causes and Projection of Climate Change over China:An Overview of Recent Progress

    Institute of Scientific and Technical Information of China (English)


    This article summarizes the main results and findings of studies conducted by Chinese scientists in the past five years.It is shown that observed climate change in China bears a strong similarity with the global average.The country-averaged annual mean surface air temperature has increased by 1.1℃over the past 50 years and 0.5-0.8℃ over the past 100 years.slightly higher than the global temperature increase for the same periods.Northern China and winter have experienced the greatest increases in surface air temperature.Although no significant trend has been found in country-averaged annual precipitation,interdecadal variability and obvious trends on regional scales are detectable,with northwestern China and the mid and lower Yangtze River basin having undergone an obvious increase,and North China a severe drought.Some analyses show that frequency and magnitude of extreme weather and climate events have also undergone significant changes in the past 50 years or so.Studies of the causes of regional climate change through the use of climate models and consideration of various forcings,show that the warming of the last 50 years could possibly be attributed to an increased atmospheric concentration of greenhouse gases,while the temperature change of the first half of the 20th century may be due to solar activity,volcanic eruptions and sea surface temperature change.A significant decline in sunshine duration and solar radiation at the surface in eastern China has been attributed to the increased emission of pollutants.Projections of future climate by models of the NCC(National Climate Center,China Meteorological Administration)and the IAP(Institute of Atmospheric Physics,Chinese Academy of Sciences),as well as 40 modeis developed overseas,indicate a potential significant warming in China in the 21st century,with the largest warming set to occur in winter months and in northern China.Under varied emission scenarios,the country-averaged annual mean temperature is

  2. Modulation of cadmium-induced mitochondrial dysfunction and volume changes by temperature in rainbow trout (Oncorhynchus mykiss)

    Energy Technology Data Exchange (ETDEWEB)

    Onukwufor, John O. [Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada C1A 4P3 (Canada); Kibenge, Fred [Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada C1A 4P3 (Canada); Stevens, Don [Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada C1A 4P3 (Canada); Kamunde, Collins, E-mail: [Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada C1A 4P3 (Canada)


    Highlights: • Interactions of Cd and temperature exacerbate mitochondrial dysfunction and enhance Cd accumulation. • Cd uptake by mitochondria occurs through the Ca uniporter. • Temperature exacerbates Cd-induced mitochondrial volume changes. • Low concentrations of Cd inhibit mitochondrial swelling. - Abstract: We investigated how temperature modulates cadmium (Cd)-induced mitochondrial bioenergetic disturbances, metal accumulation and volume changes in rainbow trout (Oncorhynchus mykiss). In the first set of experiments, rainbow trout liver mitochondrial function and Cd content were measured in the presence of complex I substrates, malate and glutamate, following exposure to Cd (0–100 μM) at three (5, 13 and 25 °C) temperatures. The second set of experiments assessed the effect of temperature on Cd-induced mitochondrial volume changes, including the underlying mechanisms, at 15 and 25 °C. Although temperature stimulated both state 3 and 4 rates of respiration, the coupling efficiency was reduced at temperature extremes due to greater inhibition of state 3 at low temperature and greater stimulation of state 4 at the high temperature. Cadmium exposure reduced the stimulatory effect of temperature on state 3 respiration but increased that on state 4, consequently exacerbating mitochondrial uncoupling. The interaction of Cd and temperature yielded different responses on thermal sensitivity of state 3 and 4 respiration; the Q{sub 10} values for state 3 respiration increased at low temperature (5–13 °C) while those for state 4 increased at high temperature (13–25 °C). Importantly, the mitochondria accumulated more Cd at high temperature suggesting that the observed greater impairment of oxidative phosphorylation with temperature was due, at least in part, to a higher metal burden. Cadmium-induced mitochondrial volume changes were characterized by an early phase of contraction followed by swelling, with temperature changing the kinetics and

  3. Could a change in magnetic field geometry cause the break in the wind-activity relation?

    CERN Document Server

    Vidotto, A A; Jardine, M; See, V; Petit, P; Boisse, I; Saikia, S Boro; Hebrard, E; Jeffers, S V; Marsden, S C; Morin, J


    Wood et al suggested that mass-loss rate is a function of X-ray flux ($\\dot{M} \\propto F_x^{1.34}$) for dwarf stars with $F_x \\lesssim F_{x,6} \\equiv 10^6$ erg cm$^{-2}$ s$^{-1}$. However, more active stars do not obey this relation. These authors suggested that the break at $F_{x,6}$ could be caused by significant changes in magnetic field topology that would inhibit stellar wind generation. Here, we investigate this hypothesis by analysing the stars in Wood et al's sample that had their surface magnetic fields reconstructed through Zeeman-Doppler Imaging (ZDI). Although the solar-like outliers in the $\\dot{M}$ -- $F_x$ relation have higher fractional toroidal magnetic energy, we do not find evidence of a sharp transition in magnetic topology at $F_{x,6}$. To confirm this, further wind measurements and ZDI observations at both sides of the break are required. As active stars can jump between states with highly toroidal to highly poloidal fields, we expect significant scatter in magnetic field topology to exi...

  4. Causes and temporal changes in nationally collected stillbirth audit data in high-resource settings. (United States)

    Norris, Tom; Manktelow, Bradley N; Smith, Lucy K; Draper, Elizabeth S


    Few high-income countries have an active national programme of stillbirth audit. From the three national programmes identified (UK, New Zealand, and the Netherlands) steady declines in annual stillbirth rates have been observed over the audit period between 1993 and 2014. Unexplained stillbirth remains the largest group in the classification of stillbirths, with a decline in intrapartum-related stillbirths, which could represent improvements in intrapartum care. All three national audits of stillbirths suggest that up to half of all reviewed stillbirths have elements of care that failed to follow standards and guidance. Variation in the classification of stillbirth, cause of death and frequency of risk factor groups limit our ability to draw meaningful conclusions as to the true scale of the burden and the changing epidemiology of stillbirths in high-income countries. International standardization of these would facilitate direct comparisons between countries. The observed declines in stillbirth rates over the period of perinatal audit, a possible consequence of recommendations for improved antenatal care, should serve to incentivise other countries to implement similar audit programmes.

  5. Microclimatic changes caused by different plastic coverings in greenhouses cultivated with cherry tomato in southern Brazil

    Directory of Open Access Journals (Sweden)

    Ester Holcman


    Full Text Available In regions with intense solar radiation it is common the use of aluminated covers in greenhouses, with the aim of reducing the inside temperature. However, the use of these covers reduces photosynthetic active radiation (PAR transmitted into the greenhouse. The objective of the present study was to evaluate the influence of different covers on microclimate in greenhouses cultivated with cherry tomato during three growing seasons. The environment I was covered with plastic film anti-UV and with thermo-reflective screen (40% disposed internally. The environment II was covered with diffusive plastic film (55%. The transmitted solar radiation to the interior of covered environments was, on average, 5.5 MJ m-2 day-1 in the environment I and 8.2 MJ m-2 day-1 in environment II. The air temperature in environment II was, on average, 1°C higher than external conditions. The highest difference for the relative humidity (RH was also observed between environment II and the outside conditions, with 10.7% for the minimum RH during the first growing period. Considering all growing periods, the diffusive plastic film provided higher solar energy availability inside the greenhouse than the plastic film with thermo-reflective screen, without causing major changes in air temperature and relative humidity, and promoting greater productivity of tomato grown under this environment for the three periods evaluated.

  6. Maternal high-fat diets cause insulin resistance through inflammatory changes in fetal adipose tissue. (United States)

    Murabayashi, N; Sugiyama, T; Zhang, L; Kamimoto, Y; Umekawa, T; Ma, N; Sagawa, N


    Epidemiological and animal studies have shown that maternal obesity predisposes the offspring to obesity and the metabolic syndrome, possibly via late-onset metabolic programming of the fetus. Little is known, however, about the metabolic effect of maternal obesity on the fetus. This study investigated the effect of a maternal high-fat diet (HFD) on fetal growth and glucose metabolism using a diet-induced obesity mouse model. Female mice (6 weeks old; C57BL/6N) were fed either a normal chow diet (NCD, 10 kcal% fat) or an HFD (60 kcal% fat) for 4 weeks before mating and throughout pregnancy. At 17 days of gestation, gene expression of inflammatory markers and adipokines in fetal subcutaneous adipose tissue was analyzed by quantitative real-time polymerase chain reaction. HFD mice were overweight, glucose intolerant and insulin resistant compared with NCD mice of the same gestational age. Although fetal body weight was not significantly different, fetal plasma glucose and insulin levels were higher in the HFD group than the NCD group. Furthermore, examination of fetal subcutaneous adipose tissue in the HFD group revealed hypertrophy with an increase in the levels of cluster of differentiation-68, chemokine receptor-2 and tumor necrosis factor-α mRNA, but a decrease in the level of glucose transporter-4 mRNA. Maternal HFD causes inflammatory changes in the adipose tissue of offspring. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  7. Assessing Change in Agricultural Productivity Caused by Drought and Conflict in Northern Syria using Landsat Imagery. (United States)

    Girgin, T.; Ozdogan, M.


    Until recently, agricultural production in Syria has been an important source of revenue and food security for the country. At its peak, agriculture in Syria accounted for 25 percent of the country's GDP. In 2014, Syrian agriculture accounted for less than 5 percent of the GDP. This decline in agricultural productivity is the cause of a 3-year long drought that started in 2007, followed by a still-ongoing conflict that started in mid-2011. Using remote sensing tools, this paper focuses on the impact that the 2007-2010 drought had on agricultural production, as well as the impact that the ongoing conflict had on the agricultural production in northern Syria. Remote sensing is a powerful and great solution to study regions of the world that are hard-to-reach due to conflict and/or other limitations. It is particularly useful when studying a region that inaccessible due to an ongoing conflict, such as in northern Syria. Using multi-temporal Landsat 5 and Landsat 8 images from August 2006, 2010 and 2014 and utilizing the neural networks algorithm, we assessed for agricultural output change in northern Syria. We conclude that the ongoing Syrian conflict has had a bigger impact on the agricultural output in northern Syria than the 3-year long drought.

  8. Change in Tear Film Lipid Layer Thickness, Corneal Thickness, Volume and Topography after Superficial Cauterization for Conjunctivochalasis. (United States)

    Chan, Tommy C Y; Ye, Cong; Ng, Paul K F; Li, Emmy Y M; Yuen, Hunter K L; Jhanji, Vishal


    We evaluated the change in tear film lipid layer thickness, corneal thickness, volume and topography after superficial cauterization of symptomatic conjunctivochalasis. Bilateral superficial conjunctival cauterization was performed in 36 eyes of 18 patients with symptomatic conjunctivochalasis. The mean age of patients (12 males, 6 females) was 68.6 ± 10.9 years (range: 44-83 years). Preoperatively, 28 eyes (77.8%) had grade 1 conjunctivochalasis, and 8 eyes (22.2%) had grade 2 conjunctivochalasis. At 1 month postoperatively, the severity of conjunctivochalasis decreased significantly (p corneal thickness, thinnest corneal thickness and corneal volume decreased significantly postoperatively (p corneal thickness and volume were observed after surgical correction of conjunctivochalasis.

  9. Clinical study on the changes of the tumor target volume and organs at risk in helical tomotherapy for nasopharyngeal carcinoma

    Institute of Scientific and Technical Information of China (English)

    LU Na; FENG Lin-chun; CAI Bo-ning; HOU Jun; WANG Yun-lai; XIE Chuan-bin


    Background Helical tomotherapy (HT) is a new image-guided intensity-modulated radiation therapy (IMRT).The aim of this study was to evaluate the changes in the target volume and organs at risk (OARs) of patients with nasopharyngeal carcinoma (NPC) during helical tomotherapy.Methods Forty-three patients with NPC and treated via HT from March 2008 to January 2010 were reviewed retrospectively.Repeated CT scanning and plan adaptation were conducted at the 20th fraction during radiotherapy.The volumetric differences between the two scans were evaluated for nasopharyngeal tumor and retro- pharyngeal lymph nodes (GTVnx),neck lymph nodes (GTVnd),and parotid glands,as well as the axial diameter of the head.Results The median interval between the two scans was 25 days (23-28 days).The volumetric decrease in GTVnx was 30.1% (median,29.8%) and in GTVnd 41.6% (median,45.9%).The variation in the GTVnd volume was correlated with the weight loss of the patient.The volume of the left parotid gland decreased by 35.5% (median,33.4%) and of the right parotid glands decreased by 36.8% (median,33.5%).The axial diameter of the head decreased by 9.39% (median,9.1%).Conclusions The target volume and OARs of patients with NPC varied considerably during HT.These changes may have potential dosimetric effects on the target volume and/or OARs and influence the clinical outcome.Repeated CT scanning and replanning during the HT for NPC patients with a large target volume or an obvious weight loss are recommended.

  10. Does upper premolar extraction affect the changes of pharyngeal airway volume after bimaxillary surgery in skeletal class III patients? (United States)

    Kim, Min-Ah; Park, Yang-Ho


    The purpose of this study was to assess the pharyngeal airway volume change after bimaxillary surgery in patients with skeletal Class III malocclusion and evaluate the difference in postoperative pharyngeal airway space between upper premolar extraction cases and nonextraction cases. Cone-beam computed tomographic scans were obtained for 23 patients (13 in extraction group and 10 in nonextraction group) who were diagnosed with mandibular prognathism before surgery (T0) and then 2 months (T2) and 6 months after surgery (T3). Using InVivoDental 3-dimensional imaging software, volumetric changes in the pharyngeal airway space were assessed at T0, T2, and T3. The Wilcoxon signed-rank test was used to determine whether there were significant changes in pharyngeal airway volume between time points. The Mann-Whitney U test was used to determine whether there were significant differences in volumetric changes between the extraction and nonextraction groups. Volumes in all subsections of the pharyngeal airway were decreased (P bimaxillary surgery. Copyright © 2014 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.



    Perkins, Kenneth A.; Parzynski, Craig S.; Mercincavage, Melissa; Conklin, Cynthia A.; Fonte, Carolyn A.


    Social learning theory considers self-efficacy as a causal factor in behavior change. However, in line with behavioral theory, recent clinical research suggests that self-efficacy ratings may reflect, rather than cause, behavior change. To test these two disparate views, self-efficacy was related to actual smoking abstinence on the next day (i.e. self-efficacy causes change), and abstinence status over one day was tested as a predictor of rated self-efficacy for being quit the next day (i.e. ...


    Directory of Open Access Journals (Sweden)

    O. M. Zubrovskaya


    Full Text Available Arboreal plants intensively accumulate heavy metals, resulting in a corresponding revocation level of physiological processes. The lipid components operate an important role in the formation of plant resistance. Therefore, it was very important to determine the characteristics of lipid peroxidation flow in leaves of arboreal plants, and changes in the composition of cuticle surface lipids at different levels of heavy metal accumulation. Research objects were Populus italica (Du Roi Moench and Betula pendula Roth. of second age group, growing on the industrial site РJSC ‘Kryvyi Rig Factory of minium’ (with strong contamination and in the arboretum of Kryvyi Rig Botanic Garden, National Academy of Science of Ukraine (conventional control. Leaves were taken from the middle of the crown southwest exposure in phase of leaf full separation and 5-10 day of phase finishing point of their growth. It was shown that P. italica maximally accumulated zinc, content of which was increased in the phase of leaf full separation and on 5-10 day of phase of leaf growth finishing point relative to the control to 12,6 and 23 times respectively. The accumulation level of heavy metals was typically less significant for assimilation organs of B. pendula compared to P. italica. Thus, the content of zinc and lead in the leaves during the study increased only in 2 times towards control. The leaves of B. pendula, unlike P. italica, more intensively accumulated cadmium in the phase of leaf full separation and on 5-10 day of phase finishing point of their growth (it was 6 and 15 times higher relative to control respectively. It was obviously connected to the fact that the surface texture of poplar leaves may cause intense sticking of dust particles containing heavy metals and penetration into the leaves. The effect of heavy metals in both phases of leaf morphogenesis caused an increase in lipid peroxidation by 40-52% for P. italica and almost by 3 times for B

  13. Chronic homocysteine exposure causes changes in the intrinsic electrophysiological properties of cultured hippocampal neurons. (United States)

    Schaub, Christina; Uebachs, Mischa; Beck, Heinz; Linnebank, Michael


    Homocystinuria is an inborn error of metabolism characterized by plasma homocysteine levels up to 500 μM, premature vascular events and mental retardation. Mild elevations of homocysteine plasma levels up to 25 μM, which are common in the general population, are associated with vascular disease, cognitive impairment and neurodegeneration. Several mechanisms of homocysteine neurotoxicity have been investigated. However, information on putative effects of hyperhomocysteinemia on the electrophysiology of neurons is limited. To screen for such effects, we examined primary cultures of mouse hippocampal neurons with the whole-cell patch-clamp technique. Homocysteine was applied intracellularly (100 μM), or cell cultures were incubated with 100 μM homocysteine for 24 h. Membrane voltage was measured in current-clamp mode, and action potential firing was induced with short and prolonged current injections. Single action potentials induced by short current injections (5 ms) were not altered by acute application or incubation of homocysteine. When we elicited trains of action potentials with prolonged current injections (200 ms), a broadening of action potentials during repetitive firing was observed in control neurons. This spike broadening was unaltered by acute application of homocysteine. However, it was significantly diminished when incubation with homocysteine was extended to 24 h prior to recording. Furthermore, the number of action potentials elicited by low current injections was reduced after long-term incubation with homocysteine, but not by the acute application. After 24 h of homocysteine incubation, the input resistance was reduced which might have contributed to the observed alterations in membrane excitability. We conclude that homocysteine exposure causes changes in the intrinsic electrophysiological properties of cultured hippocampal neurons as a mechanism of neurological symptoms of hyperhomocysteinemia.

  14. Change of the melanocortin system caused by bilateral subthalamic nucleus stimulation in Parkinson's disease. (United States)

    Escamilla-Sevilla, F; Pérez-Navarro, M J; Muñoz-Pasadas, M; Sáez-Zea, C; Jouma-Katati, M; Piédrola-Maroto, G; Ramírez-Navarro, A; Mínguez-Castellanos, A


    OBJECTIVES - Determine whether bilateral subthalamic nucleus stimulation (STN-DBS) in Parkinson's disease (PD) is associated with an increase in neuropeptide Y (NPY) and/or resistance to inhibition by leptin in relation to post-surgery weight gain. MATERIALS AND METHODS - This prospective study included 20 patients who underwent bilateral STN-DBS and 17 who refused surgery. Data were obtained at baseline, 3 and 6 months on neurological and nutritional status, including determination of body mass index (BMI) and serum NPY and leptin levels. RESULTS -  NPY and leptin levels changed over time, with a distinct pattern. The BMI increase at 6 months was greater in the surgical group (5.5 ± 6.3% vs 0.5 ± 3.5%; P = 0.035). Medical group exhibited a reduction in leptin level (-2.0 ± 4.3 ng/ml) and a consequent increase in NPY level (72.4 ± 58.7 pmol/ml). However, STN-DBS patients showed an increase in leptin (3.1 ± 5.0 ng/ml; P = 0.001 vs medical group) and also in NPY (12.1 ± 53.6 pmol/ml; P = 0.022 vs medical group) levels, which suggests resistance to inhibition by leptin. Rise in NPY level correlated with higher stimulation voltages. CONCLUSIONS -  Bilateral STN-DBS causes disruption of the melanocortin system, probably related to diffusion of the electric current to the hypothalamus. This mechanism may in part explain the weight gain of patients with PD after surgery.

  15. Repeated predictable stress causes resilience against colitis-induced behavioral changes in mice (United States)

    Hassan, Ahmed M.; Jain, Piyush; Reichmann, Florian; Mayerhofer, Raphaela; Farzi, Aitak; Schuligoi, Rufina; Holzer, Peter


    Inflammatory bowel disease is associated with an increased risk of mental disorders and can be exacerbated by stress. In this study which was performed with male 10-week old C57Bl/6N mice, we used dextran sulfate sodium (DSS)-induced colitis to evaluate behavioral changes caused by intestinal inflammation, to assess the interaction between repeated psychological stress (water avoidance stress, WAS) and colitis in modifying behavior, and to analyze neurochemical correlates of this interaction. A 7-day treatment with DSS (2% in drinking water) decreased locomotion and enhanced anxiety-like behavior in the open field test and reduced social interaction. Repeated exposure to WAS for 7 days had little influence on behavior but prevented the DSS-induced behavioral disturbances in the open field and SI tests. In contrast, repeated WAS did not modify colon length, colonic myeloperoxidase content and circulating proinflammatory cytokines, parameters used to assess colitis severity. DSS-induced colitis was associated with an increase in circulating neuropeptide Y (NPY), a rise in the hypothalamic expression of cyclooxygenase-2 mRNA and a decrease in the hippocampal expression of NPY mRNA, brain-derived neurotrophic factor mRNA and mineralocorticoid receptor mRNA. Repeated WAS significantly decreased the relative expression of corticotropin-releasing factor mRNA in the hippocampus. The effect of repeated WAS to blunt the DSS-evoked behavioral disturbances was associated with a rise of circulating corticosterone and an increase in the expression of hypothalamic NPY mRNA. These results show that experimental colitis leads to a particular range of behavioral alterations which can be prevented by repeated WAS, a model of predictable chronic stress, while the severity of colitis remains unabated. We conclude that the mechanisms underlying the resilience effect of repeated WAS involves hypothalamic NPY and the hypothalamic-pituitary-adrenal axis. PMID:25414650

  16. Repeated Predictable Stress Causes Resilience against Colitis-Induced Behavioral Changes in Mice

    Directory of Open Access Journals (Sweden)

    Ahmed M Hassan


    Full Text Available Inflammatory bowel disease is associated with an increased risk of mental disorders and can be exacerbated by stress. In this study which was performed with male 10-week old C57Bl/6N mice, we used dextran sulfate sodium (DSS-induced colitis to evaluate behavioral changes caused by intestinal inflammation, to assess the interaction between repeated psychological stress (water avoidance stress, WAS and colitis in modifying behavior, and to analyze neurochemical correlates of this interaction. A 7-day treatment with DSS (2 % in drinking water decreased locomotion and enhanced anxiety-like behavior in the open field test and reduced social interaction. Repeated exposure to WAS for 7 days had little influence on behavior but prevented the DSS-induced behavioral disturbances in the open field and social interaction tests. In contrast, repeated WAS did not modify colon length, colonic myeloperoxidase content and circulating proinflammatory cytokines, parameters used to assess colitis severity. DSS-induced colitis was associated with an increase in circulating neuropeptide Y (NPY, a rise in the hypothalamic expression of cyclooxygenase-2 mRNA and a decrease in the hippocampal expression of NPY mRNA, brain-derived neurotrophic factor mRNA and mineralocorticoid receptor mRNA. Repeated WAS significantly decreased the relative expression of corticotropin-releasing factor mRNA in the hippocampus. The effect of repeated WAS to blunt the DSS-evoked behavioral disturbances was associated with a rise of circulating corticosterone and an increase in the expression of hypothalamic NPY mRNA. These results show that experimental colitis leads to a particular range of behavioral alterations which can be prevented by repeated WAS, a model of predictable chronic stress, while the severity of colitis remains unabated. We conclude that the mechanisms underlying the resilience effect of repeated WAS involves hypothalamic NPY and the hypothalamic-pituitary-adrenal axis.

  17. Semiautomated three-dimensional segmentation software to quantify carpal bone volume changes on wrist CT scans for arthritis assessment. (United States)

    Duryea, J; Magalnick, M; Alli, S; Yao, L; Wilson, M; Goldbach-Mansky, R


    Rapid progression of joint destruction is an indication of poor prognosis in patients with rheumatoid arthritis. Computed tomography (CT) has the potential to serve as a gold standard for joint imaging since it provides high resolution three-dimensional (3D) images of bone structure. The authors have developed a method to quantify erosion volume changes on wrist CT scans. In this article they present a description and validation of the methodology using multiple scans of a hand phantom and five human subjects. An anthropomorphic hand phantom was imaged with a clinical CT scanner at three different orientations separated by a 30-deg angle. A reader used the semiautomated software tool to segment the individual carpal bones of each CT scan. Reproducibility was measured as the root-mean-square standard deviation (RMMSD) and coefficient of variation (CoV) between multiple measurements of the carpal volumes. Longitudinal erosion progression was studied by inserting simulated erosions in a paired second scan. The change in simulated erosion size was calculated by performing 3D image registration and measuring the volume difference between scans in a region adjacent to the simulated erosion. The RMSSD for the total carpal volumes was 21.0 mm3 (CoV = 1.3%) for the phantom, and 44.1 mm3 (CoV = 3.0%) for the in vivo subjects. Using 3D registration and local volume difference calculations, the RMMSD was 1.0-3.0 mm3 The reader time was approximately 5 min per carpal bone. There was excellent agreement between the measured and simulated erosion volumes. The effect of a poorly measured volume for a single erosion is mitigated by the large number of subjects that would comprise a clinical study and that there will be many erosions measured per patient. CT promises to be a quantifiable tool to measure erosion volumes and may serve as a gold standard that can be used in the validation of other modalities such as magnetic resonance imaging.

  18. Glacier length, area and volume changes in the Himalaya: an overview and specific examples (United States)

    Bolch, T.; Bhambri, R.; Kamp, U.; Pieczonka, T.


    The Himalaya comprises one of the largest glacier-covered areas outside the polar regions. Glaciers are of special interest for several reasons. For instance, receding glaciers can cause the development of hazardous glacial lakes and glaciers contribute to the overall river runoff. The importance of the glacier melt to run off, however, varies significantly depending especially on the precipitation regime. Previous studies indicate that the vast majority of the Himalayan glaciers retreated during the recent decades with only few exemptions. Although the numbers of investigates glaciers increased in the last few years, there is still a lack of knowledge about the glacier behaviour in the different regions of the Himalaya. Existing length measurements in the Indian Himalaya show continuous retreat with an accelerating trend in recent years for most of the glaciers. The annual retreat rates vary between ~5m and more than 50m. However, several measurements are based on topographic maps or coarse satellite data and can have therefore higher uncertainties. Own reassessments for the debris-covered Gangotri Glacier situated in Garhwal Himalaya/western India based on high resolution imagery such as Corona, Hexagon, IRS PAN, LISS IV, and Cartosat-1 show an continuous retreat with an average rate of 19.9 ± 0.3 m a-1 from 1965 to 2006. This is significant but less than previously published. Similar results were revealed for the area changes in upper Alaknanda and Bhagirathi valleys in Garhwal Himalaya. We found a lower but still significant area loss of 4.6 ± 2.8 % between 1968 and 2006. Area changes in Khumbu Himalaya/Nepal are with ~5% between 1962 and 2005 comparable. Investigations in the Greater Himalayan Range in southern Ladakh/northwest India revealed a general receding trend but with some of the larger glaciers with high altitude catchments being stable or even advancing. Preliminary results for Shyok Valley (Jammu and Kashmir) show on average stable or slightly

  19. Long-term global and regional brain volume changes following severe traumatic brain injury: A longitudinal study with clinical correlates

    DEFF Research Database (Denmark)

    Sidaros, Annette; Skimminge, Arnold Jesper Møller; Liptrot, Matthew George;


    Traumatic brain injury (TBI) results in neurodegenerative changes that progress for months, perhaps even years post-injury. However, there is little information on the spatial distribution and the clinical significance of this late atrophy. In 24 patients who had sustained severe TBI we acquired 3D...... scan time point using SIENAX. Regional distribution of atrophy was evaluated using tensor-based morphometry (TBM). At the first scan time point, brain parenchymal volume was reduced by mean 8.4% in patients as compared to controls. During the scan interval, patients exhibited continued atrophy...... with percent brain volume change (%BVC) ranging between − 0.6% and − 9.4% (mean − 4.0%). %BVC correlated significantly with injury severity, functional status at both scans, and with 1-year outcome. Moreover, %BVC improved prediction of long-term functional status over and above what could be predicted using...

  20. Early changes in left atrial volume after acute myocardial infarction. Relation to invasive hemodynamics at rest and during exercise

    DEFF Research Database (Denmark)

    Bakkestrøm, Rine; Andersen, Mads J; Ersbøll, Mads


    BACKGROUND: Dilatation of left atrium (LA) reflects chronic LA pressure or volume overload that possesses considerable prognostic information. Little is known regarding the interaction between LA remodeling after acute myocardial infarction (MI) and left atrial pressure at rest and during exercise...... associated with resting and exercise induced changes in LA pressure overload. The dilatation was however associated with lower e' and higher MR-proANP....

  1. Quantum-Mechanical QSPR Models for Polymerization Volume Change of Epoxides and Methacrylates Based on Mercury Dilatometry Results


    Miller, Matthew D.; Holder, Andrew J.; Kilway, Kathleen V.; Giese, Gregory J.; Finley, Jason E.; Travis, DeAnna M.; Iwai, Benjamin T.; Eick, J. David


    Polymerization volume change (PVC) was measured systematically using mercury dilatometry for 41 epoxide and methacrylate monomers with quartz filler. Quantitative structure property relationship (QSPR) models were developed based on this previously unreported data to gain insight in the data collection method for future models. Successful models included only data from those samples which polymerized to hardness. The most significant descriptors in these models related to monomer reactivity. ...

  2. Changes in hippocampal volume and neuron number co-occur with memory decline in old homing pigeons (Columba livia). (United States)

    Coppola, Vincent J; Kanyok, Nate; Schreiber, Austin J; Flaim, Mary E; Bingman, Verner P


    The mammalian hippocampus is particularly susceptible to age-related structural changes, which have been used to explain, in part, age-related memory decline. These changes are generally characterized by atrophy (e.g., a decrease in volume and number of synaptic contacts). Recent studies have reported age-related spatial memory deficits in older pigeons similar to those seen in older mammals. However, to date, little is known about any co-occurring changes in the aging avian hippocampal formation (HF). In the current study, it was found that the HF of older pigeons was actually larger and contained more neurons than the HF of younger pigeons, a finding that suggests that the pattern of structural changes during aging in the avian HF is different from that seen in the mammalian hippocampus. A working hypothesis for relating the observed structural changes with spatial-cognitive decline is offered.

  3. A Black Cohosh Extract Causes Hematologic and Biochemical Changes Consistent with a Functional Cobalamin Deficiency in Female B6C3F1/N Mice. (United States)

    Cora, Michelle C; Gwinn, William; Wilson, Ralph; King, Debra; Waidyanatha, Suramya; Kissling, Grace E; Brar, Sukhdev S; Olivera, Dorian; Blystone, Chad; Travlos, Greg


    Black cohosh rhizome, available as a dietary supplement, is most commonly marketed as a remedy for dysmenorrhea and menopausal symptoms. A previous subchronic toxicity study of black cohosh dried ethanolic extract (BCE) in female mice revealed a dose-dependent ineffective erythropoiesis with a macrocytosis consistent with the condition known as megaloblastic anemia. The purpose of this study was to investigate potential mechanisms by which BCE induces these particular hematological changes. B6C3F1/N female mice (32/group) were exposed by gavage to vehicle or 1,000 mg/kg BCE for 92 days. Blood samples were analyzed for hematology, renal and hepatic clinical chemistry, serum folate and cobalamin, red blood cell (RBC) folate, and plasma homocysteine and methylmalonic acid (MMA). Folate levels were measured in liver and kidney. Hematological changes included decreased RBC count; increased mean corpuscular volume; and decreased reticulocyte, white blood cell, neutrophil, and lymphocyte counts. Blood smear evaluation revealed increased Howell-Jolly bodies and occasional basophilic stippling in treated animals. Plasma homocysteine and MMA concentrations were increased in treated animals. Under the conditions of our study, BCE administration caused hematological and clinical chemistry changes consistent with a functional cobalamin, and possibly folate, deficiency. Further studies are needed to elucidate the mechanism by which BCE causes increases in homocysteine and MMA.

  4. Pituitary volumes of the patients with borderline personality disorder are not changed. (United States)

    Atmaca, Murad; Karakoc, Tevfik; Mermi, Osman; Kilic, Faruk; Gurok, M Gurkan; Yildirim, Hanefi


    Although it has important relationships with psychiatric symptoms via the hypothalamic-pituitary-adrenal axis, there have been limited investigations of pituitary neuroimaging in psychiatric disorder. Moreover, there have been no studies of borderline personality disorder. In the present investigation, we examined pituitary gland volumes in patients with borderline personality disorder. Seventeen right-handed female patients with borderline personality disorder, selected among the patients who had presented to Firat University School of Medicine Department of Psychiatry outpatient and inpatient clinics, and the same number of healthy control subjects were included in the present investigation. Pituitary gland volumes were manually detected. The results demonstrated that the mean volumes of the gland of the patients with borderline personality disorder were not significantly different than those of healthy control subjects (mean volume of 0.79 cm3 in the patient group, with a value of SD±0.11 and 0.81 cm3 in the healthy control group, with a value of SD±0.23; t=-0.21; p>0.05). © The Author(s) 2015.

  5. Estimating changes in Stroke Volume by non-invasive pulse-oximetry Pulse Transit Time Measurements

    NARCIS (Netherlands)

    ten Bokkel-Andela, J.; Poterman, Marieke; Scheeren, Thomas; Kalmar, A.F.


    Background and Goal of Study:  Pulse wave transit time (PTT), the interval between the R-wave peak on an electrocardiogram (ECG) and arrival of the pulse waves in the periphery (e.g. the finger), is reported to be a reliable estimate for stroke volume[1,2]. In this study, the PTT based on ECG and th

  6. Silver-cotton nanocomposites: Nano-design of microfibrillar structure causes morphological changes and increased tenacity (United States)

    Nam, Sunghyun; Condon, Brian D.; Delhom, Christopher D.; Fontenot, Krystal R.


    The interactions of nanoparticles with polymer hosts have important implications for directing the macroscopic properties of composite fibers, yet little is known about such interactions with hierarchically ordered natural polymers due to the difficulty of achieving uniform dispersion of nanoparticles within semi-crystalline natural fiber. In this study we have homogeneously dispersed silver nanoparticles throughout an entire volume of cotton fiber. The resulting electrostatic interaction and distinct supramolecular structure of the cotton fiber provided a favorable environment for the controlled formation of nanoparticles (12 ± 3 nm in diameter). With a high surface-to-volume ratio, the extensive interfacial contacts of the nanoparticles efficiently “glued” the structural elements of microfibrils together, producing a unique inorganic-organic hybrid substructure that reinforced the multilayered architecture of the cotton fiber.

  7. Confined-Volume Effect on the Thermal Properties of Encapsulated Phase Change Materials for Thermal Energy Storage. (United States)

    De Castro, Paula F; Ahmed, Adham; Shchukin, Dmitry G


    We have encapsulated the heat exchange material, n-docosane, into polyurethane capsules of different sizes. Decreasing the size of the capsules leads to changes of the crystallinity of phase-change material as well as melting/crystallization temperature. The novelty of the paper includes 1) protection of the nanostructured energy-enriched materials against environment during storage and controlled release of the encapsulated energy on demand and 2) study of the structure and surface-to-volume properties of the energy-enriched materials dispersed in capsules of different sizes. The stability of energy nanomaterials, influence of capsule diameter on their energy capacity, homogeneity and operation lifetime are investigated.

  8. Airflow behavior changes in upper airway caused by different head and neck positions: Comparison by computational fluid dynamics. (United States)

    Wei, Wei; Huang, Shi-Wei; Chen, Lian-Hua; Qi, Yang; Qiu, Yi-Min; Li, Shi-Tong


    The feasibility of computational fluid dynamics (CFD) to evaluate airflow characteristics in different head and neck positions has not been established. This study compared the changes in volume and airflow behavior of the upper airway by CFD simulation to predict the influence of anatomical and physiological airway changes due to different head-neck positions on mechanical ventilation. One awake volunteer with no risk of difficult airway underwent computed tomography in neutral position, extension position (both head and neck extended), and sniffing position (head extended and neck flexed). Three-dimensional airway models of the upper airway were reconstructed. The total volume (V) and narrowest area (Amin) of the airway models were measured. CFD simulation with an Spalart-Allmaras model was performed to characterize airflow behavior in neutral, extension, and sniffing positions of closed-mouth and open-mouth ventilation. The comparison result for V was neutral volume and decreasing airway resistance, suggesting that sniffing position may be the optimal choice for mask ventilation.

  9. Epigenetic-Imprinting Changes Caused by Neonatal Fasting Stress Protect From Future Fasting Stress. (United States)

    Jiang, Y; Denbow, C; Meiri, N; Denbow, D M


    Unfavourable nutritional conditions during the neonatal critical period can cause both acute metabolic disorders and severe metabolic syndromes in later life. These phenomena have been tightly related to the epigenetic modification controlling the balance between satiety and hunger in the hypothalamus. In the present study, we investigated epigenetic modification associated with both the fasting stress effects and the short-term resilience to fasting stress in the hypothalamic paraventricular nucleus (PVN) of chicks. Fasting for 24 h at 3 days of age (D) (i.e. D3) significantly increased global methylation at lysine 27 of histone 3 (H3K27) and its specific histone methyltransferase (HMT) expression level in the PVN. Because global methylation could not fully reveal the changes at specific genes, the regulation of the gene for brain-derived neurotrophic factor (Bdnf), which was recently also found to have an anorexigenic effect, was evaluated as a potential target. Chromatin immunoprecipitation assay analysis revealed that tri- (me3) and di-methylated (me2) H3K27 exhibited an instant (on D4 only) and latent increase (on both D11 and D41), respectively, at the putative promoter of Bdnf after 24 h of fasting on D3. This indicated that fasting could regulate energy-expenditure-related genes via modifying methylation at H3K27, which we suspected might be a protective mechanism for keeping the inner environment homeostatic. To test this hypothesis, a short-term repetitive fasting stress was applied to chickens, which were fasted for 24 h either on D10 only or on both D3 and D10. It was found that pre-existing fasting on D3 could induce a short-term fasting resilience, which rescued the reduction of Bdnf expression from future fasting on D10. We call this phenomenon the ‘molecular memory’, which was mainly conducted by HMTs and H3K27me2/me3 in the PVN. In conclusion, chicks respond to fasting with dynamic methylation at H3K27 in the PVN during the neonatal critical

  10. Acute mechanical overstimulation of isolated outer hair cells causes changes in intracellular calcium levels without shape changes. (United States)

    Fridberger, A; Ulfendahl, M


    Impaired auditory function following acoustic overstimulation, or noise, is mainly reported to be accompanied by cellular changes such as damage to the sensory hair bundles, but changes in the cell bodies of the outer hair cells have also been described. To investigate more closely the immediate cellular responses to overstimulation, isolated guinea pig outer hair cells were subjected to a 200 Hz oscillating water jet producing intense mechanical stimulation. The water jet was aimed at the cell body of the isolated outer hair cell. Cell shape changes were studied using video microscopy, and intracellular calcium concentration changes were monitored by means of the fluorescent calcium indicator Fluo-3. Cells exposed to a high-intensity stimulus showed surprisingly small light-microscopical alterations. The cytoplasmic calcium concentration increased in most cells, although some cells appeared very resistant to the mechanical stress. No correlation could be found be tween the calcium concentration changes and the cell length. The changes in calcium concentration reported here are suggested to be involved in the long-term pathogenesis of noise-induced hair cell damage.

  11. Changes in cause-specific mortality among the elderly in Canada, 1979–2011

    DEFF Research Database (Denmark)

    Bergeron Boucher, Marie-Pier; Bourbeau, Robert; Légáre, Jacques


    par âge des causes de décès. Nos résultats suggèrent que la majorité des gains en espérance de vie à 65 et 85 ans proviennent d’une plus faible mortalité par cause de décès sénescente. De plus, une diminution des principales causes de décès chez les personnes âgées de 65 ans et plus laisse place à une...

  12. Glacial – interglacial atmospheric CO2 change: a possible "standing volume" effect on deep-ocean carbon sequestration

    Directory of Open Access Journals (Sweden)

    L. C. Skinner


    Full Text Available So far, the exploration of possible mechanisms for glacial atmospheric CO2 draw-down and marine carbon sequestration has focussed almost exclusively on dynamic or kinetic processes (i.e. variable mixing-, equilibration- or export rates. Here an attempt is made to underline instead the possible importance of changes in the standing volumes of intra-oceanic carbon reservoirs (i.e. different water-masses in setting the total marine carbon inventory. By way of illustration, a simple mechanism is proposed for enhancing the carbon storage capacity of the deep sea, which operates via an increase in the volume of relatively carbon-enriched AABW-like deep-water filling the ocean basins. Given the hypsometry of the ocean floor and an active biological pump, the water-mass that fills more than the bottom 3 km of the ocean will essentially determine the carbon content of the marine reservoir. A set of simple box-model experiments confirm the expectation that a deep sea dominated by AABW-like deep-water holds more CO2, prior to any additional changes in ocean overturning rate, biological export or ocean-atmosphere exchange. The magnitude of this "standing volume effect" might be as large as the contributions that have been attributed to carbonate compensation, the thermodynamic solubility pump or the biological pump for example. If incorporated into the list of factors that have contributed to marine carbon sequestration during past glaciations, this standing volume mechanism may help to reduce the amount of glacial – interglacial CO2 change that remains to be explained by other mechanisms that are difficult to assess in the geological archive, such as reduced mass transport or mixing rates in particular. This in turn could help narrow the search for forcing conditions capable of pushing the global carbon cycle between glacial and interglacial modes.

  13. Changes in causes of death among persons with AIDS: San Francisco, California, 1996-2011. (United States)

    Schwarcz, Sandra K; Vu, Annie; Hsu, Ling Chin; Hessol, Nancy A


    The increased life expectancy among HIV-infected persons treated with combination antiretroviral therapy (ART), risk behaviors, and co-morbidities associated with ART place HIV-infected persons at risk for non-HIV-related causes of death. We used the San Francisco HIV/AIDS registry to identify deaths that occurred from January 1996 through December 2011. Temporal trends in AIDS- and non-AIDS-related mortality rates, the proportion of underlying and contributory causes of death, and the ratio of observed deaths in the study population to expected number of deaths among California men aged 20-79 (standardized mortality ratio [SMR]) of underlying causes of death were examined. A total of 5338 deaths were identified. The annual AIDS-related death rate (per 100 deaths) declined from 10.8 in 1996 to 0.9 in 2011 (p<0.0001), while the annual death rate from non-AIDS-related causes declined from 2.1 in 1996 to 0.9 in 2011 (p<0.0001). The proportion of deaths due to all types of heart disease combined, all non-AIDS cancers combined, mental disorders resulting from substance abuse, drug overdose, suicide and chronic obstructive pulmonary disease increased significantly over time. The SMRs for liver diseased decreased significantly over time but remained elevated. Our data highlight the importance of age-related causes of death as well as deaths from causes that are, at least in part, preventable.

  14. Stability, Tunneling and Flux Changing de Sitter Transitions in the Large Volume String Scenario

    CERN Document Server

    de Alwis, S; Hatefi, E; Quevedo, F


    We study the non-perturbative stability of the Large Volume Scenario (LVS) of IIB string compactifications, by analysing transitions mediated by the Brown-Teitelboim (BT) brane nucleations and by Coleman De Luccia tunneling (CDL). We find that, as long as the effective field theory description holds, the LVS AdS minima are stable despite being non-supersymmetric. This opens the possibility of having a CFT dual. Metastable de Sitter vacua behave differently depending on the uplifting mechanism. We find explicit expressions for the different decay rates in terms of exponentials of the volume. Among the transitions of dS to dS those with increasing volume and decreasing vacuum energy are preferred, though dS decays to AdS (big-crunch sinks) have higher probability. Transitions via the CDL mechanism to decompactification are exponentially suppressed compared to these. The BT decays correspond to flux/D3 brane transitions mediated by the nucleation of D5/NS5 branes. We compare our results with previous analysis fo...

  15. Evidence for a multi-species coccolith volume change over the past two centuries: understanding a potential ocean acidification response

    Directory of Open Access Journals (Sweden)

    P. R. Halloran


    Full Text Available Major questions surround the species-specific nature of coccolithophore calcification in response to rising atmospheric CO2 levels. Here we present CaCO3 particle volume distribution data from the coccolith size-fraction of a rapidly accumulating North Atlantic sediment core. Without direct volume measurements on coccoliths produced by individual coccolithophore species, and knowledge of organic, as well as inorganic carbon production, it is not possible to state conclusively the coccolithophore calcification change at this site. However, by analysing the size distribution of CaCO3 particles in the less than 10 μm sediment fraction, we demonstrate a changing particle volume since the late 20th Century consistent with an increase in the mass of coccoliths produced by the larger coccolithophore species, and potentially a decrease in mass of coccoliths produced by the smaller species, present at this location. This finding has significant implications for the realistic representation of an assemblage-wide coccolithophore CO2-calcification response in numerical models.

  16. Forearm skin tissue dielectric constant measured at 300 MHz: effect of changes in skin vascular volume and blood flow. (United States)

    Mayrovitz, Harvey N; Guo, Xiaoran; Salmon, Mark; Uhde, Matt


    Skin tissue dielectric constant (TDC) values measured via the open-ended coaxial probe method are useful non-invasive indices of local skin tissue water. However, the effect of skin blood flow (SBF) or skin blood volume (SBV) on TDC values is unknown. To determine the magnitude of such effects, we decreased forearm SBV via vertical arm raising for 5 min (test 1) and increased SBV by bicep cuff compression to 50 mmHg for 5 min (test 2) in 20 healthy supine subjects (10 men). TDC values were measured to a depth of 1·5 mm on anterior forearm, and SBF was measured with laser-Doppler system simultaneously on forearm and finger. Results indicate that decreasing vascular volume (test 1) was associated with a small but statistically significant reduction in TDC (3·0 ± 4·3%, P = 0·003) and increasing vascular volume (test 2) was associated with a slight but statistically significant increase in TDC (3·5 ± 3·0%, PTDC values (3·0-3·5%) over the wide range of induced SBV and SBF changes suggest a minor effect on clinically determined TDC values because of SBV or SBF changes or differences when comparing TDC longitudinally over time or among individuals of different groups in a research setting.


    Energy Technology Data Exchange (ETDEWEB)



    Aqueous homogeneous solution reactors have been proposed for the production of medical isotopes. However, the reactivity effects of fuel solution volume change, due to formation of radiolytic gas bubbles and thermal expansion, have to be mitigated to allow steady-state operation of solution reactors. The results of the free run experiments analyzed indicate that the proposed model to estimate the void volume due to radiolytic gas bubbles and thermal expansion in solution reactors can accurately describe the observed behavior during the experiments. This void volume due to radiolytic gas bubbles and fuel solution thermal expansion can then be used in the investigation of reactivity effects in fissile solutions. In addition, these experiments confirm that the radiolytic gas bubbles are formed at a higher temperature than the fuel solution temperature. These experiments also indicate that the mole-weighted average for the radiolytic gas bubbles in uranyl fluoride solutions is about 1 {micro}m. Finally, it should be noted that another model, currently under development, would simulate the power behavior during the transient given the initial fuel solution level and density. The model is based on Monte Carlo simulation with the MCNP computer code [Briesmeister, 1997] to obtain the reactor reactivity as a function of the fuel solution density, which, in turn, changes due to thermal expansion and radiolytic gas bubble formation.

  18. Recording and Calculating Gunshot Sound—Change of the Volume in Reference to the Distance (United States)

    Nikolaos, Tsiatis E.


    An experiment was conducted in an open practice ground (shooting range) regarding the recording of the sound of gunshots. Shots were fired using various types of firearms (seven pistols, five revolvers, two submachine guns, one rifle, and one shotgun) in different calibers, from several various distances with reference to the recording sources. Both, a conventional sound level meter (device) and a measurement microphone were used, having been placed in a fixed point behind the shooting line. The sound of each shot was recorded (from the device). At the same time the signal received by the microphone was transferred to a connected computer through an appropriate audio interface with a pre-amplifier. Each sound wave was stored and depicted as a wave function. After the physic-mathematical analysis of these depictions, the volume was calculated in the accepted engineering units(Decibels or dB) of Sound Pressure Level (SPL). The distances from the recording sources were 9.60 meters, 14.40 m, 19.20 m, and 38.40 m. The experiment was carried out by using the following calibers: .22 LR, 6.35 mm(.25 AUTO), 7.62 mm Tokarev(7,62×25), 7.65 mm(.32 AUTO), 9 mm Parabellum(9×19), 9 mm Short(9×17), 9 mm Makarov(9×18), .45 AUTO, .32 S&W, .38 S&W, .38 SPECIAL, .357 Magnum, 7,62 mm Kalashnikov(7,62×39) and 12 GA. Tables are given for the environmental conditions (temperature, humidity, altitude & barometric pressure), the length of the barrel of each gun, technical characteristics of the used ammunition, as well as for the volume taken from the SLM. The data for the sound intensity were collected after 168 gunshots (158 single shot & 10 bursts). According to the results, a decreasing of the volume, equivalent to the increasing of the distance, was remarked, as it was expected. Values seem to follow the Inverse square Law. For every doubling of the distance from the sound source, the sound intensity diminishes by 5.9904±0.2325 decibels (on average). In addition, we have the

  19. The Causes and Risk-Taking on the Change of CEO Equity-Based Compensation Structure


    Yin-Hua Yeh; Zih-Heng Lai


    This paper explores to find out the determinants of the change of CEO equity-based compensation structure. We use the US nonfinancial listed companies as sample and find that when the change of stock return and size increase positively, the percentage of stock compensation and the stock-minus-option compensation relative to last year increase. Moreover, when the change of CEO duality increases positively, the percentage of stock-compensation and the percentage of stock-minus-option compensati...

  20. Parallel Changes in Intracellular Water Volume and pH Induced by NH3/NH4+ Exposure in Single Neuroblastoma Cells

    Directory of Open Access Journals (Sweden)

    Víctor M. Blanco


    Full Text Available Background: Increased blood levels of ammonia (NH3 and ammonium (NH4+, i.e. hyperammonemia, leads to cellular brain edema in humans with acute liver failure. The pathophysiology of this edema is poorly understood. This is partly due to incomplete understanding of the osmotic effects of the pair NH3/NH4+ at the cellular and molecular levels. Cell exposure to solutions containing NH3/NH4+ elicits changes in intracellular pH (pHi, which can in turn affect cell water volume (CWV by activating transport mechanisms that produce net gain or loss of solutes and water. The occurrence of CWV changes caused by NH3/NH4+ has long been suspected, but the mechanisms, magnitude and kinetics of these changes remain unknown. Methods: Using fluorescence imaging microscopy we measured, in real time, parallel changes in pHi and CWV caused by brief exposure to NH3/NH4+ of single cells (N1E-115 neuroblastoma or NG-108 neuroblastoma X glioma loaded with the fluorescent indicator BCECF. Changes in CWV were measured by exciting BCECF at its intracellular isosbestic wavelength (∼438 nm, and pHi was measured ratiometrically. Results: Brief exposure to isosmotic solutions (i.e. having the same osmolality as that of control solutions containing NH4Cl (0.5- 30 mM resulted in a rapid, dose-dependent swelling, followed by isosmotic regulatory volume decrease (iRVD. NH4Cl solutions in which either extracellular [NH3] or [NH4+] was kept constant while the other was changed by varying the pH of the solution, demonstrated that [NH3]o rather than [NH4+]o is the main determinant of the NH4Cl-induced swelling. The iRVD response was sensitive to the anion channel blocker NPPB, and partly dependent on external Ca2+. Upon removal of NH4Cl, cells shrank and displayed isosmotic regulatory volume increase (iRVI. Regulatory volume responses could not be activated by comparable CWV changes produced by anisosmotic solutions, suggesting that membrane stretch or contraction by themselves are

  1. Changes caused by hydrocephalus, induced by kaolin, in the corpus callosum of adult dogs. (United States)

    Cardoso, Edvaldo José Rodrigues; Lachat, João José; Lopes, Luiza Silva; Santos, Antonio Carlos dos; Colli, Benedicto Oscar


    To analyze the ventricular enlargement and myelination of the corpus callosum in adult dogs after four and eight weeks of kaolin-induction of hydrocephalus. 36 dogs were randomly divided into 3 groups: 1 - without hydrocephalus, 2 - kaolin-induction of hydrocephalus until the fourth week, and 3 - kaolin-induction of hydrocephalus until the eighth week. Ventricular ratios and volumes were calculated using magnetic resonance images, and myelination of the corpus callosum were histologically evaluated using solocromo-cianin stain. Radiological hydrocephalus was observed in 93.75% and overall mortality was 38.4%. Ventricular volumes and ratios were higher in groups 2 and 3 compared to group 1 and similar when measures in the fourth and eighth weeks were compared in the group 3. Indices of luminescence in the knee and in the splenium of the corpus callosum were higher in group 2 than in group 1 indicating that there was loss of myelin in group 2, and similar in groups 1 and 3, showing a tendency to remyelination after 8 weeks. The corpus callosum of dogs with kaolin-induced hydrocephalus responds with demyelination of the knee and splenium by the fourth week with a tendency to remyelination by the eighth week.

  2. Increasing fill volume reduces cardiac performance in peritoneal dialysis

    DEFF Research Database (Denmark)

    Ivarsen, Per; Povlsen, Johan V; Jensen, Jens Dam


    BACKGROUND: It is generally accepted that peritoneal dialysis (PD) affects systemic haemodynamics less than haemodialysis, but little is known about changes in haemodynamics during PD. It is unknown if increasing PD volume causes changes in cardiovascular haemodynamics possibly increasing...

  3. Seasonal hysteresis of net ecosystem exchange in response to temperature change: Patterns and causes

    NARCIS (Netherlands)

    Niu, S.; Luo, Y.; Montagnani, L.; Janssens, I.A.; Gielen, B.; Rambal, S.; Moors, E.J.; Matteucci, G.


    Understanding how net ecosystem exchange (NEE) changes with temperature is central to the debate on climate change-carbon cycle feedbacks, but still remains unclear. Here, we used eddy covariance measurements of NEE from 20 FLUXNET sites (203 site-years of data) in mid- and high-latitude forests to

  4. PS-109 Barriers and facilitators to implementing drug changes caused by drug tenders and shortages

    DEFF Research Database (Denmark)

    Rishøj, Rikke Mie; Christrup, Lona Louring; Clemmensen, Marianne H


    Background Drug tenders and shortages result in drug changes. International studies found that drug changes can adversely affect patient safety and the working procedures of healthcare professionals.1,2 The challenges of drug changes in Danish public hospitals have not previously been studied...... for drug identification during drug shortages were proposed. Conclusion This study identified different barriers and facilitators for implementing drug changes. The barriers and facilitators included specific features related to drugs, health care technology as well as to financial and organisational...... aspects. Future studies should focus on removal of barriers and development and implementation of appropriate facilitators which may indeed improve patient safety and the working procedures of healthcare professionals during drug changes....

  5. Causes and impacts of changes in the stratospheric meridional circulation in a chemistry-climate model

    Energy Technology Data Exchange (ETDEWEB)

    Garny, Hella


    The stratospheric meridional circulation is projected to be subject to changes due to enhanced greenhouse-gas concentrations in the atmosphere. This study aims to diagnose and explain long-term changes in the stratospheric meridional circulation using the chemistry-climate model E39CA. The diagnosed strengthening of the circulation is found to be driven by increases in tropical sea surface temperatures which lead to a strengthening and upward shift of the subtropical jets. This enables enhanced vertical propagation of large scale waves into the lower stratosphere, and therefore stronger local wave forcing of the meridional circulation in the tropical lower stratosphere. The impact of changes in transport on the ozone layer is analysed using a newly developed method that allows the separation of the effects of transport and chemistry changes on ozone. It is found that future changes of mean stratospheric ozone concentrations are largely determined by changes in chemistry, while changes in transport of ozone play a minor role. (orig.)

  6. Changing Fortunes: How China’s Boom Caused the Financial Crisis

    NARCIS (Netherlands)

    H. Mees (Heleen)


    textabstractThis dissertation includes five academic papers that – one way or the other – all relate to China. The first paper delivers proof for the central thesis of this thesis, which is that China’s boom caused the 2008 financial crisis and ensuing recession. As much as I hoped from the outset

  7. Changes in the proteome of Mastitis-causing escherichia coli strains that affect pathogenesis (United States)

    Escherichia coli is a leading cause of bacterial mastitis in dairy cattle. Milk is the environment in which bacteria must grow to establish an infection of the mammary gland. However, milk is not a rich growth media for bacteria. In fact, milk naturally contains many mechanisms to inhibit bacterial ...

  8. Changes in nectar supply: A possible cause of widespread butterfly decline

    NARCIS (Netherlands)

    Wallis de Vries, M.F.; Swaay, van C.A.M.; Plate, C.L.


    Recent studies have documented declining trends of various groups of flower-visiting insects, even common butterfly species. Causes of these declines are still unclear but the loss of habitat quality across the wider countryside is thought to be a major factor. Nectar supply constitutes one of the m

  9. Wildlife conservation and animal temperament: causes and consequences of evolutionary change for captive, reintroduced, and wild populations

    NARCIS (Netherlands)

    McDougall, P.T.; Réale, D.; Sol, D.; Reader, S.M.


    We argue that animal temperament is an important concept for wildlife conservation science and review causes and consequences of evolutionary changes in temperament traits that may occur in captive-breeding programmes. An evolutionary perspective is valid because temperament traits are heritable,

  10. Linking sediment-charcoal records and ecological modeling to understand causes of fire-regime change in boreal forests (United States)

    Linda B. Brubaker; Philip E. Higuera; T. Scott Rupp; Mark A. Olson; Patricia M. Anderson; Feng Sheng. Hu


    Interactions between vegetation and fire have the potential to overshadow direct effects of climate change on fire regimes in boreal forests of North America. We develop methods to compare sediment-charcoal records with fire regimes simulated by an ecological model, ALFRESCO (Alaskan Frame-based Ecosystem Code) and apply these methods to evaluate potential causes of a...

  11. Wildlife conservation and animal temperament: causes and consequences of evolutionary change for captive, reintroduced, and wild populations

    NARCIS (Netherlands)

    McDougall, P.T.; Réale, D.; Sol, D.; Reader, S.M.


    We argue that animal temperament is an important concept for wildlife conservation science and review causes and consequences of evolutionary changes in temperament traits that may occur in captive-breeding programmes. An evolutionary perspective is valid because temperament traits are heritable, li

  12. 76 FR 62777 - Forum-Trends and Causes of Observed Changes in Heat Waves, Cold Waves, Floods and Drought (United States)


    ... National Oceanic and Atmospheric Administration Forum--Trends and Causes of Observed Changes in Heat Waves...: Notice of open public forum. SUMMARY: This notice sets forth the schedule and topics of an upcoming forum... the forum, and are required to RSVP to by 5 p.m. EDT, Tuesday, October 25...

  13. Climate change: evidence of human causes and arguments for emissions reduction. (United States)

    Baum, Seth D; Haqq-Misra, Jacob D; Karmosky, Chris


    In a recent editorial, Raymond Spier expresses skepticism over claims that climate change is driven by human actions and that humanity should act to avoid climate change. This paper responds to this skepticism as part of a broader review of the science and ethics of climate change. While much remains uncertain about the climate, research indicates that observed temperature increases are human-driven. Although opinions vary regarding what should be done, prominent arguments against action are based on dubious factual and ethical positions. Thus, the skepticisms in the recent editorial are unwarranted. This does not diminish the general merits of skeptical intellectual inquiry.

  14. Abrupt climate-induced changes in carbonate burial in the Arabian Sea: Causes and consequences.

    Digital Repository Service at National Institute of Oceanography (India)

    Naidu, P.D.; Singh, A.D.; Ganeshram, R.S.; Bharti, S.K.

    teleconnections. We suggest that the role of aragonite carbonate production and burial in margins and the resultant CO2 climate feedback to rapid climate changes remains poorly constrained....

  15. Rapid climate change did not cause population collapse at the end of the European Bronze Age. (United States)

    Armit, Ian; Swindles, Graeme T; Becker, Katharina; Plunkett, Gill; Blaauw, Maarten


    The impact of rapid climate change on contemporary human populations is of global concern. To contextualize our understanding of human responses to rapid climate change it is necessary to examine the archeological record during past climate transitions. One episode of abrupt climate change has been correlated with societal collapse at the end of the northwestern European Bronze Age. We apply new methods to interrogate archeological and paleoclimate data for this transition in Ireland at a higher level of precision than has previously been possible. We analyze archeological (14)C dates to demonstrate dramatic population collapse and present high-precision proxy climate data, analyzed through Bayesian methods, to provide evidence for a rapid climatic transition at ca. 750 calibrated years B.C. Our results demonstrate that this climatic downturn did not initiate population collapse and highlight the nondeterministic nature of human responses to past climate change.

  16. Migration and sensory changes of packaging materials caused by ionising radiation (United States)

    Welle, Frank; Mauer, Alexandra; Franz, Roland


    Irradiation of packaging materials—in most cases plastics—generally lead to a formation of free radicals and ions, with secondary effects such as cross-linking as well as oxidative chain scission. These effects result in a formation of volatile radiolysis products which may induce off-odours in the polymers and may change the migration characteristics of packaging materials. Irradiation affect also polymer additives which change the specific migration behaviour of polymer additives and additive related decomposition products. Migration and sensory changes of pre-sterilised packaging materials have consequences on the quality of packaged goods and consumer's safety. Therefore, migration and sensory properties of packaging materials have specific regulations. Within this paper the effects of the formation of radiolysis products on overall migration, specific migration of food additives or radiolysis products as well as on sensory changes are discussed in view of current European food law.

  17. Quantifying elasticity analysis: how external effectors cause changes to metabolic systems. (United States)

    Ainscow, E K; Brand, M D


    The sites of action of external effectors, such as inhibitors or hormones, on metabolic systems can be described qualitatively by elasticity analysis, or quantitatively by regulation analysis. The use of the latter approach has been limited, due to its practical complexity. In this study, we report mathematical relationships that relate the finite changes in system variables (fluxes and metabolite concentrations) to changes in activity of metabolic processes brought about by a single step addition of an effector. The activation or inhibition of a process by an effector is measured from changes in flux and intermediate levels. The changes in activity of each process can be used to describe, semi-quantitatively, which activations or inhibitions of the system processes are important in bringing about the observed levels of system variables.

  18. Pulmonary Edema and Plasma Volume Changes in Dysbarism. M.S. Thesis - Texas Univ. (United States)

    Joki, J. A.


    Two groups of anesthetized, fasted pigs were utilized. One group of 13 animals (8.5 to 16.6 kilograms) was exposed to a high-pressure environment, and the other group of eight animals (6.9 to 20.0 kilograms) constituted the control group. The experimental group was subjected to an atmosphere of 90 percent nitrogen and 10 percent oxygen at a pressure of 50 psig for 30 minutes and then decompressed at a rate 10 psi/min. Plasma volumes, using both iodine-125-tagged-albumin and chromium-51-tagged-cell dilution techniques, were measured before, immediately after, and at 30 and 60 minutes after decompression. Aortic and right-ventricular systolic pressures were also recorded. At 60 minutes after decompression, blood samples were taken, the animals were sacrificed, and the water content of the lungs, kidneys, livers, and spleens was estimated by measuring tissue wet weight and dry weight. Protein extravasation and tissue blood volumes were determined by measuring the iodine-125-tagged-albumin and chromium-51-tagged-cell spaces in homo-genates of the organs under investigation.

  19. [Kimura's disease: an unrecognized cause of adult-onset nephrotic syndrome with minimal change disease]. (United States)

    Shehwaro, N; Langlois, A-L; Gueutin, V; Debchi, L; Charlotte, F; Rouvier, P; Rottembourg, J; Izzedine, H


    Kimura's disease (KD) is an angiolymphoid proliferative disorder of soft tissue with eosinophilia, with a predilection for head and neck regions in young Oriental men. Kidney disease is thought to be rare in KD. About a case of adult-onset nephrotic syndrome with minimal change disease, we comment Kimura's disease and its associated kidney damage. Kimura disease should be suspected and included in the diagnosis of adult-onset nephrotic syndrome with minimal change disease.

  20. Climate Change and Its Causes, A Discussion About Some Key Issues

    CERN Document Server

    Scafetta, Nicola


    This article discusses the limits of the Anthropogenic Global Warming Theory advocated by the Intergovernmental Panel on Climate Change. A phenomenological theory of climate change based on the physical properties of the data themselves is proposed. At least 60% of the warming of the Earth observed since 1970 appears to be induced by natural cycles which are present in the solar system. A climatic stabilization or cooling until 2030-2040 is forecast by the phenomenological model.

  1. Quantifying seasonal volume of groundwater in high elevation meadows: Implications for complex aquifer geometry in a changing climate (United States)

    Ciruzzi, Dominick M.

    The hydrologic impacts of rising global temperatures are severe and imminent particularly in snow-dominated regions. In the western United States, high elevation meadows are among the ecosystems highly sensitive to climate change. High elevation meadows are groundwater dependent ecosystems and rely on seasonal snowpack melt in order to support ecologic function and baseflow to streams. This stream flow in turn supplies an estimated 2.6 million San Francisco residents with water. Once the snow melts and recharges the aquifer, groundwater supports vegetation separate from the surrounding hillslopes, which promotes important ecologic functions like flood regulation and nutrient cycling. Groundwater also supports baseflow to perennial rivers late into the summer months transferring this snowmelt to downstream ecologic and human communities. By 2100 snowpack accumulation in the Sierra Nevada is expected to decrease by ~40-90% due to near-surface temperature rise. Though precipitation intensity is not expected to change, a decrease in snowpack will change the timing and magnitude of groundwater recharge necessary to sustain high elevation meadows. An additional climate-driven shift and decrease in peak stream flow to early spring away from summer when demand is highest puts into question ecosystem survivability and water supply to downstream users. Here, a new quantitative framework is presented to lay the foundation for the widespread identification of vulnerabilities in high elevation meadows due to climate change. This research proposed and tested a new conceptual model for the volume of groundwater stored in high elevation meadows similar to that of a reservoir with active and dead storage. The seasonal fluctuations in active storage, which is defined as the volume of groundwater able to exchange between the aquifer, streams, and vegetation, are thought to be highly sensitive to aquifer parameters, such as bedrock geometry, meadow gradient, and hydraulic conductivity

  2. [The effect of physical therapy on the most severe forms of knee structral changes caused by osteoarthritis]. (United States)

    Kapidzić-Basić, Nedima; Dzananović, Dzevad; Kapidzić-Duraković, Suada; Kikanović, Sahza; Mulić-Bacić, Suada; Hotić-Hadziefendić, Asja


    In the most severe form of structural changes on knee caused by osteoarthritis non-surgical treatment provide minimal results and a question of its purpose is being raised. Aim of the study was to examine the possibilities of physical treatment of patients with the most severe degree of structural changes caused by knee osteoarthritis. Examination was conducted on 60 patients that were on physical treatment because of the knee OA. Structural changes are evaluated by Kellgren-Lawrence scale, functional ability by Lequesne index, and pain by Visual analog scale. Physical treatment lasted for 4 weeks. After the physical treatment there was a significant improvement of functional ability (p = 1.78E-07), but the size of improvement was reduced by the level of structural changes. It was significantly lower in IV class in relation to III and II class (p Physical treatment has lower affect by patients with the most severe form of structural changes caused by knee osteoarthritis, but it still can help patients to ease the appearance of complete dependence on other people's help.

  3. Histological changes caused by meclofenamic acid in androgen independent prostate cancer tumors: evaluation in a mouse model

    Directory of Open Access Journals (Sweden)

    Iván Delgado-Enciso


    Full Text Available ABSTRACT Meclofenamic acid is a nonsteroidal anti-inflammatory drug that has shown therapeutic potential for different types of cancers, including androgen-independent prostate neoplasms. The antitumor effect of diverse nonsteroidal anti-inflammatory drugs has been shown to be accompanied by histological and molecular changes that are responsible for this beneficial effect. The objective of the present work was to analyze the histological changes caused by meclofenamic acid in androgen-independent prostate cancer. Tumors were created in a nude mouse model using PC3 cancerous human cells. Meclofenamic acid (10 mg/kg/day; experimental group, n=5 or saline solution (control group, n=5 was administered intraperitoneally for twenty days. Histological analysis was then carried out on the tumors, describing changes in the cellular architecture, fibrosis, and quantification of cellular proliferation and tumor vasculature. Meclofenamic acid causes histological changes that indicate less tumor aggression (less hypercellularity, fewer atypical mitoses, and fewer nuclear polymorphisms, an increase in fibrosis, and reduced cellular proliferation and tumor vascularity. Further studies are needed to evaluate the molecular changes that cause the beneficial and therapeutic effects of meclofenamic acid in androgen-independent prostate cancer.

  4. Observed change of the standardized precipitation index, its potential cause and implications to future climate change in the Amazon region. (United States)

    Li, Wenhong; Fu, Rong; Juárez, Robinson I Negrón; Fernandes, Katia


    Observations show that the standard precipitation index (SPI) over the southern Amazon region decreased in the period of 1970-1999 by 0.32 per decade, indicating an increase in dry conditions. Simulations of constant pre-industrial climate with recent climate models indicate a low probability (p=0%) that the trends are due to internal climate variability. When the 23 models are forced with either anthropogenic factors or both anthropogenic and external natural factors, approximately 13% of sampled 30-year SPI trends from the models are found to be within the range of the observed SPI trend at 95% confidence level. This suggests a possibility of anthropogenic and external forcing of climate change in the southern Amazon. On average, the models project no changes in the frequency of occurrence of low SPI values in the future; however, those models which produce more realistic SPI climatology, variability and trend over the period 1970-1999 show more of a tendency towards more negative values of SPI in the future. The analysis presented here suggests a potential anthropogenic influence on Amazon drying, which warrants future, more in-depth, study.


    Directory of Open Access Journals (Sweden)

    Svätoslav Hluchý


    Full Text Available The aim of this study was to find the quantitative and structural changes in the rat testis and changes of semen quality after a diazinon administration. METHODS: Rats received diazinon (99% purity in thier drinking water (40 mg.l-1 with free access. Age of rats at the beginning of the experiment was 30 days and experiment lasted for next 90 days. The histological samples were evaluated by histological and morphometric methods in light microscopy and the samples of semen were evaluated with CASA method. RESULTS: Disintergation of cellular associations in the seminiferous epithelium, germ cells evacuation into the tubule lumen and thier necrosis were mostly observed. Rarely vacuolisation and cracks of epithelium and fibrotisation of interstitial tissue were noted. Morphometric methods have shown extension of epithelium (P subcellular structures and their functions may be damaged which can lead to subfertility. Further investigation of diazinon is needed for verification of our hypothesis.doi:10.5219/188

  6. Local and global volume changes of subcortical brain structures from longitudinally varying neuroimaging data for dementia identification. (United States)

    Unay, Devrim


    Quantification of structural changes in the human brain is important to elicit resemblances and differences between pathological and normal aging. Identification of dementia, associated with loss of cognitive ability beyond normal aging, and especially converters--the subgroup of individuals at risk for developing dementia--has recently gained importance. For this purpose atrophy markers have been explored and their effectiveness has been evaluated both cross-sectionally and longitudinally. However, more research is needed to understand the dynamics of atrophy markers at different disease stages, which requires temporal analysis of local along with global changes. Unfortunately, most of the longitudinal neuroimaging data available in the clinical settings is acquired at largely varying time intervals. In the light of the above, this study presents a novel methodology to process longitudinal neuroimaging data acquired incompletely and at different time intervals, and explores complementary nature of local and global brain volume changes in identifying dementia. Results on the OASIS database demonstrate discriminative power of global atrophy in hippocampus (as early as two years after the first visit) for identifying demented cases, and local volume shrinkage of thalamus proper (as early as three years after the first visit) for differentiating converters.

  7. Induction of Inducible Nitric Oxide Synthase by Lipopolysaccharide and the Influences of Cell Volume Changes, Stress Hormones and Oxidative Stress on Nitric Oxide Efflux from the Perfused Liver of Air-Breathing Catfish, Heteropneustes fossilis. (United States)

    Choudhury, Mahua G; Saha, Nirmalendu


    The air-breathing singhi catfish (Heteropneustes fossilis) is frequently being challenged by bacterial contaminants, and different environmental insults like osmotic, hyper-ammonia, dehydration and oxidative stresses in its natural habitats throughout the year. The main objectives of the present investigation were to determine (a) the possible induction of inducible nitric oxide synthase (iNOS) gene with enhanced production of nitric oxide (NO) by intra-peritoneal injection of lipopolysaccharide (LPS) (a bacterial endotoxin), and (b) to determine the effects of hepatic cell volume changes due to anisotonicity or by infusion of certain metabolites, stress hormones and by induction of oxidative stress on production of NO from the iNOS-induced perfused liver of singhi catfish. Intra-peritoneal injection of LPS led to induction of iNOS gene and localized tissue specific expression of iNOS enzyme with more production and accumulation of NO in different tissues of singhi catfish. Further, changes of hydration status/cell volume, caused either by anisotonicity or by infusion of certain metabolites such as glutamine plus glycine and adenosine, affected the NO production from the perfused liver of iNOS-induced singhi catfish. In general, increase of hydration status/cell swelling due to hypotonicity caused decrease, and decrease of hydration status/cell shrinkage due to hypertonicity caused increase of NO efflux from the perfused liver, thus suggesting that changes in hydration status/cell volume of hepatic cells serve as a potent modulator for regulating the NO production. Significant increase of NO efflux from the perfused liver was also observed while infusing the liver with stress hormones like epinephrine and norepinephrine, accompanied with decrease of hydration status/cell volume of hepatic cells. Further, oxidative stress, caused due to infusion of t-butyl hydroperoxide and hydrogen peroxide separately, in the perfused liver of singhi catfish, resulted in

  8. Regulation of Cancer-Causing Food Additives-Time for a Change? (United States)


    A specific level is too confining; a range of risk should be used. Views on labeling A consensus emerged among food safety experts we interviewed...1965 FDA set an action level of 30 parts per billion (ppb) for aflatoxin , a potent carcinogen produced by a fungus found primarily on corn and peanuts... levels , FDA considered the economic and technological feasibility of reducing the contamination. According to FDA, aflatoxin was not banned be- cause

  9. Exposure to Cobalt Causes Transcriptomic and Proteomic Changes in Two Rat Liver Derived Cell Lines (United States)


    Cobalt can enter the body through respiration, ingestion, or contact with the skin . The adverse effects of an inhalation exposure occur mostly in the lung...exposures are unlikely to have systemic effects as cobalt cannot readily penetrate normal skin , although contact with cobalt can cause dermatitis [16...heavy chain 4 Mug1/Mug2 murinoglobulin 1/2 NAMPT nicotinamide phosphoribosyltransferase Pzp pregnancy zone protein SERPINA1 serine (or cysteine

  10. Effect of change in blood volume in skin plus active muscle on heart rate drift during submaximal exercise


    Yano,T.; T Yunoki; Matsuura, R.; Arimitsu, T.; Kimura, T.


    The purpose of the present study was to examine the effect of change in blood volume in skin plus active muscle on heart rate drift during moderate exercise and heavy exercise for 30 min. Total hemoglobin concentration (Total Hb) in the vastus lateralis muscle plus its skin was determined by near-infrared spectroscopy. Total Hb significantly increased and remained stable from 20 min in moderate exercise and from 10 min in heavy exercise. Heart rate (HR) rapidly increased until 3 min and showe...

  11. Local control of emission energy of semiconductor quantum dots using volume expansion of a phase-change material (United States)

    Takahashi, Motoki; Syafawati Humam, Nurrul; Tsumori, Nobuhiro; Saiki, Toshiharu; Regreny, Philippe; Gendry, Michel


    A method is proposed to precisely control the emission energy of semiconductor quantum dots (QDs) by the application of local strain due to volume expansion of a phase-change material (GeSbTe) upon amorphization. The feasibility of the method is experimentally demonstrated using photoluminescence (PL) spectroscopy of single InAs/InP QDs on which a GeSbTe thin film is deposited. A significant red-shift of the PL peak energy upon amorphization and subsequent recovery by recrystallization with laser annealing were observed.

  12. A model to estimate volume change due to radiolytic gas bubbles and thermal expansion in solution reactors

    Energy Technology Data Exchange (ETDEWEB)

    Souto, F.J. [NIS-6: Advanced Nuclear Technology, Los Alamos National Lab., Los Alamos, NM (United States); Heger, A.S. [ESA-EA: Engineering Sciences and Application, Los Alamos National Lab., Los Alamos, NM (United States)


    To investigate the effects of radiolytic gas bubbles and thermal expansion on the steady-state operation of solution reactors at the power level required for the production of medical isotopes, a calculational model has been developed. To validate this model, including its principal hypotheses, specific experiments at the Los Alamos National Laboratory SHEBA uranyl fluoride solution reactor were conducted. The following sections describe radiolytic gas generation in solution reactors, the equations to estimate the fuel solution volume change due to radiolytic gas bubbles and thermal expansion, the experiments conducted at SHEBA, and the comparison of experimental results and model calculations. (author)

  13. Mechanisms and Feedbacks Causing Changes in Upper Stratospheric Ozone in the 21st Century (United States)

    Oman, Luke; Waugh, D. W.; Kawa, S. R.; Stolarski, R. S.; Douglass, A. R.; Newman, P. A.


    Stratospheric ozone is expected to increase during the 21st century as the abundance of halogenated ozone-depleting substances decrease to 1960 values. However, climate change will likely alter this "recovery" of stratospheric ozone by changing stratospheric temperatures, circulation, and abundance of reactive chemical species. Here we quantity the contribution of different mechanisms to changes in upper stratospheric ozone from 1960 to 2100 in the Goddard Earth Observing System Chemistry-Climate Model (GEOS CCM), using multiple linear regression analysis applied to simulations using either Alb or A2 greenhouse gas (GHG) scenarios. In both these scenarios upper stratospheric ozone has a secular increase over the 21st century. For the simulation using the Alb GHG scenario, this increase is determined by the decrease in halogen amounts and the greenhouse gas induced cooling, with roughly equal contributions from each mechanism. There is a larger cooling in the simulation using the A2 GHG scenario, but also enhanced loss from higher NOy and HOx concentrations, which nearly offsets the increase due to cooler temperatures. The resulting ozone evolutions are similar in the A2 and Alb simulations. The response of ozone due to feedbacks from temperature and HOx changes, related to changing halogen concentrations, are also quantified using simulations with fixed halogen concentrations.

  14. Indication of BOLD-specific venous flow-volume changes from precisely controlled hyperoxic vs. hypercapnic calibration. (United States)

    Mark, Clarisse I; Pike, G Bruce


    Deriving cerebral metabolic rate of oxygen consumption (CMRO(2)) from blood oxygenation level-dependent (BOLD) signals involves a flow-volume parameter (α), reflecting total cerebral blood volume changes, and a calibration constant (M). Traditionally, the former is assumed a fixed value and the latter is measured under alterations in fixed inspired fractional concentrations of carbon dioxide. We recently reported on reductions in M-variability via precise control of end-tidal pressures of both hypercapnic (HC) and hyperoxic (HO) gases. In light of these findings, our aim was to apply the improved calibration alternatives to neuronal activation, making use of their distinct vasoactive natures to evaluate the α-value. Nine healthy volunteers were imaged at 3 T while simultaneously measuring BOLD and arterial spin-labeling signals during controlled, graded, HC, and HO, followed by visual (VC) and sensorimotor cortices (SMC) activation. On the basis of low M- and CMRO(2)-variability, the comparison of these calibration alternatives accurately highlighted a reduced venous flow-volume relationship (α=0.16±0.02, with α(VC)=0.12±0.04, and α(SMC)=0.20±0.02), as appropriate for BOLD modeling.

  15. Morphologic Changes of Mammary Carcinomas in Mice over Time as Monitored by Flat-Panel Detector Volume Computed Tomography

    Directory of Open Access Journals (Sweden)

    Jeannine Missbach-Guentner


    Full Text Available Noninvasive methods are strongly needed to detect and quantify not only tumor growth in murine tumor models but also the development of vascularization and necrosis within tumors. This study investigates the use of a new imaging technique, flat-panel detector volume computed tomography (fpVCT, to monitor in vivo tumor progression and structural changes within tumors of two murine carcinoma models. After tumor cell inoculation, single fpVCT scans of the entire mice were performed at different time points. The acquired isotropic, high-resolution volume data sets enable an accurate real-time assessment and precise measurements of tumor volumes. Spreading of contrast agent-containing blood vessels around and within the tumors was clearly visible over time. Furthermore, fpVCT permits the identification of differences in the uptake of contrast media within tumors, thus delineating necrosis, tumor tissues, and blood vessels. Classification of tumor tissues based on the decomposition of the underlying mixture distribution of tissue-related Hounsfield units allowed the quantitative acquisition of necrotic tissues at each time point. Morphologic alterations of the tumor depicted by fpVCT were confirmed by histopathologic examination. Concluding, our data show that fpVCT may be highly suitable for the noninvasive evaluation of tumor responses to anticancer therapies during the course of the disease.

  16. Study on dynamic characteristics' change of hippocampal neuron reduced models caused by the Alzheimer's disease. (United States)

    Peng, Yueping; Wang, Jue; Zheng, Chongxun


    In the paper, based on the electrophysiological experimental data, the Hippocampal neuron reduced model under the pathology condition of Alzheimer's disease (AD) has been built by modifying parameters' values. The reduced neuron model's dynamic characteristics under effect of AD are comparatively studied. Under direct current stimulation, compared with the normal neuron model, the AD neuron model's dynamic characteristics have obviously been changed. The neuron model under the AD condition undergoes supercritical Andronov-Hopf bifurcation from the rest state to the continuous discharge state. It is different from the neuron model under the normal condition, which undergoes saddle-node bifurcation. So, the neuron model changes into a resonator with monostable state from an integrator with bistable state under AD's action. The research reveals the neuron model's dynamic characteristics' changing under effect of AD, and provides some theoretic basis for AD research by neurodynamics theory.

  17. Impact of body composition changes on risk of all-cause mortality in older adults

    DEFF Research Database (Denmark)

    Graf, Christophe E; Herrmann, François R; Spoerri, Adrian


    PURPOSE: This study evaluates the relationship between body mass index (BMI), fat mass index (FMI) and fat-free mass index (FFMI) changes and mortality in persons ≥65 years. METHODS: Adults ≥65 years with at least two body composition measurements (BCM) between 1990 and 2011 were included. We...... excluded persons who died within one month of the second BCM and who had two single BCM in a one-month timeframe. Mortality data was retrieved until December 2012. For each person, we calculated the regression slopes for BMI, FMI and FFMI changes. Significant positive slopes were categorized as "gain......", negative slopes as "loss" and the others as "maintenance". The impact of body composition changes was evaluated by Cox regression models while adjusting for sex, age, co-morbidities and body composition at the last measurement. RESULTS: We included 791 persons with 3049 BCM. After adjustment for sex...

  18. Macrosegregation Caused by Convection Associated with Directional Solidification through Cross-Section Change (United States)

    Ghods, M.; Lauer, M.; Tewari, S. N.; Poirier, D. R..; Grugel, R. N.


    Al-7 wt% Si and Pb-6 wt% Sb alloy samples were directionally solidified (DS), with liquid above and solid below and gravity pointing down, in cylindrical graphite crucibles through an abrupt cross-section change. Fraction eutectic distribution in the microstructure, primary dendrite spacing and primary dendrite trunk diameters have been measured in the DS samples in the vicinity of section change in order to examine the effect of convection associated with the combined influence of thermosolutal factors and solidification shrinkage. It is observed that convection not only produces extensive radial and axial macrosegregation near cross-section change, it also affects the dendritic array morphology. Primary dendrite spacing and primary dendrite trunk diameter, both, are influenced by this convection. In addition to the experimental results, preliminary results from a numerical model which includes solidification shrinkage and thermosolutal convection in the mushy zone in its analysis will also be presented

  19. Volume Change of Heterogeneous Quasi-brittle Materials in Uniaxial Compression

    Institute of Scientific and Technical Information of China (English)

    WANG Xuebin


    The volumetric strain was categorized into elastic and plastic parts. The former composed of axial and lateral strains is uniform and determined by Hooke's law; however, the latter consisting of axial and lateral strains is a function of thickness of shear band determined by gradient-dependent plasticity by considering the heterogeneity of quasi-brittle materials. The non-uniform lateral strain due to the fact that shear band was formed in the middle of specimen was averaged within specimen to precisely assess the volumetric strain. Then, the analytical expression for volumetric strain was verified by comparison with two earlier experimental results for concrete and rock. Finally, a detailed parametric study was carried out to investigate effects of constitutive parameters (shear band thickness, elastic and softening moduli) and geometrical size of specimen(height and width of specimen) on the volume dilatancy.

  20. The DTIC Review. Volume 1, Number 1: Nuclear Proliferation and Deterrence in a Changing Political World (United States)


    Paul Davis, Brent Bradley, Kevin Lewis, Colonel Chuck Miller, Craig Moore. Chris Bowie, Scooter Libby, Dan Drezner, and Ken Watman for their comments...have caused them to develop nuclear weapons were addressed adequately, and consequently, the nuclear weapons program was suspended. This suspension of

  1. Histological changes in mouse liver and spleen caused by different Coxiella burnetii antigenic preparations. (United States)

    Kokorin, I N; Pushkareva, V I; Kazár, J; Schramek, S


    The effect was examined on mouse liver and spleen (inbred line A) of intraperitoneal (i.p.) inoculation of phase I Coxiella burnetii (C.b.) cells either untreated or treated with chloroform-methanol (CM) mixture in comparison to the trichloracetic acid extract (TCAE) from phase I C.b.) cells. The phase I C.b. cells were highly toxic as manifested by marked hepatosplenomegaly accompanied with hyperplastic, degenerative and necrotic changes in the liver. By contrast, phase I CM--treated C.b. cells and TCAE were nontoxic as evidenced by the absence of any distinct pathological changes in mouse viscera.

  2. Magnetic field variation caused by rotational speed change in a magnetohydrodynamic dynamo. (United States)

    Miyagoshi, Takehiro; Hamano, Yozo


    We have performed numerical magnetohydrodynamic dynamo simulations in a spherical shell with rotational speed or length-of-day (LOD) variation, which is motivated by correlations between geomagnetic field and climatic variations with ice and non-ice ages. The results show that LOD variation leads to magnetic field variation whose amplitude is considerably larger than that of LOD variation. The heat flux at the outer sphere and the zonal flow also change. The mechanism of the magnetic field variation due to LOD variation is also found. The keys are changes of dynamo activity and Joule heating.

  3. Ultrastructural changes on Entamoeba histolytica HM1-IMSS caused by the flavan-3-ol, (-)-epicatechin. (United States)

    Soto, Jacqueline; Gómez, Consuelo; Calzada, Fernando; Ramírez, María Esther


    The flavan-3-ol, (-)-epicatechin has been previously identified as the most important antiamoebic compound among the extracts from two medicinal plants: Rubus coriifolius and Geranium mexicanum. Here we report the effects of epicatechin on Entamoeba histolytica morphology, analyzed by electronic microscopy. E. histolytica trophozoites were incubated for 48 h at 37 degrees C in the presence of 1.9 microg/mL epicatechin and processed for electronic microscopy analysis. Epicatechin induced nuclear and cytoplasmic changes in the treated trophozoites. These morphological alterations are identical to the cellular changes experienced by E. histolytica trophozoites undergoing programmed cell death (PCD), suggesting that epicatechin could be an alternative compound to treat amoebiasis.

  4. Causes of Climate and Environmental Changes: The Need for Environmental-Friendly Education Policy in Nigeria (United States)

    Nwankwoala, H. N. L.


    Man cannot naturally be detached from his environment. From time to time, changes in climate and environmental conditions occur as a result of natural and human factors. Obviously, the natural factors are almost beyond human control. But, the human factors are to a very large extent under human control. Thus, this paper tried to discover natural…

  5. Causes and Consequences of Changes in Nutrient Structure in the Jiaozhou Bay

    Institute of Scientific and Technical Information of China (English)

    Shu-Jiang ZHAO; Nian-Zhi JIAO; Zhi-Liang SHEN; Yu-Lin WU


    Concentrations and ratios of nutrients in Jiaozhou Bay, China, have changed much in the past decades, with trends indicating an increase in nitrogen and a decrease in silicate. Statistical analysis has shown that the long-term variations of nutrients are associated with agricultural activities, precipitation, and anthropogenic factors. Stoichiometric calculations indicate that the nutrient structure has become more and more unbalanced. There has been almost no possibility for nitrogen limitation since the 1980s, the probability of P limitation has increased, and the probability of Si limitation has also increased markedly from the 1980s to the 1990s. As a consequence of changes in nutrient structure, a decrease in the abundance of net phytoplankton was evident, whereas total chlorophyll a levels have remained roughly unchanged at around 3.55 μg/L. Thus, it is likely that smaller species have taken the niche vacated by the larger species. Changes in phytoplankton size and species composition may ultimately lead to various functional and structural changes at the system level.


    Zinc is a common metal in most ambient particulate matter (PM), and has been proposed to be a causative component in PM-induced adverse cardiovascular health effects. Zinc is also an essential metal and has the potential to induce many physiological and nonphysiological changes. ...

  7. Dynamics of inner ear pressure change caused by intracranial pressure manipulation in the guinea pig

    NARCIS (Netherlands)

    Thalen, EO; Wit, HP; Segenhout, JM; Albers, FWJ


    Previous studies have shown that pressure changes in the cerebrospinal fluid compartment are transmitted to the inner ear. The main route for pressure transfer is the cochlear aqueduct, about which little is known with regard to its dynamic properties. In the present study, sudden intracranial press

  8. Restoring piscivorous fish populations in the Laurentian Great Lakes causes seabird dietary change (United States)

    Hebert, C.E.; Weseloh, D.V.C.; Idrissi, A.; Arts, M.T.; O'Gorman, R.; Gorman, O.T.; Locke, B.; Madenjian, C.P.; Roseman, E.F.


    Ecosystem change often affects the structure of aquatic communities thereby regulating how much and by what pathways energy and critical nutrients flow through food webs. The availability of energy and essential nutrients to top predators such as seabirds that rely on resources near the water's surface will be affected by changes in pelagic prey abundance. Here, we present results from analysis of a 25-year data set documenting dietary change in a predatory seabird from the Laurentian Great Lakes. We reveal significant declines in trophic position and alterations in energy and nutrient flow over time. Temporal changes in seabird diet tracked decreases in pelagic prey fish abundance. As pelagic prey abundance declined, birds consumed less aquatic prey and more terrestrial food. This pattern was consistent across all five large lake ecosystems. Declines in prey fish abundance may have primarily been the result of predation by stocked piscivorous fishes, but other lake-specific factors were likely also important. Natural resource management activities can have unintended consequences for nontarget ecosystem components. Reductions in pelagic prey abundance have reduced the capacity of the Great Lakes to support the energetic requirements of surface-feeding seabirds. In an environment characterized by increasingly limited pelagic fish resources, they are being offered a Hobsonian choice: switch to less nutritious terrestrial prey or go hungry. ?? 2008 by the Ecological Society of America.

  9. Changes in Average Annual Precipitation in Argentina’s Pampa Region and Their Possible Causes

    Directory of Open Access Journals (Sweden)

    Silvia Pérez


    Full Text Available Changes in annual rainfall in five sub-regions of the Argentine Pampa Region (Rolling, Central, Mesopotamian, Flooding and Southern were examined for the period 1941 to 2010 using data from representative locations in each sub-region. Dubious series were adjusted by means of a homogeneity test and changes in mean value were evaluated using a hydrometeorological time series segmentation method. In addition, an association was sought between shifts in mean annual rainfall and changes in large-scale atmospheric pressure systems, as measured by the Atlantic Multidecadal Oscillation (AMO, the Pacific Decadal Oscillation (PDO and the Southern Oscillation Index (SOI. The results indicate that the Western Pampas (Central and Southern are more vulnerable to abrupt changes in average annual rainfall than the Eastern Pampas (Mesopotamian, Rolling and Flooding. Their vulnerability is further increased by their having the lowest average rainfall. The AMO showed significant negative correlations with all sub-regions, while the PDO and SOI showed significant positive and negative correlations respectively with the Central, Flooding and Southern Pampa. The fact that the PDO and AMO are going through the phases of their cycles that tend to reduce rainfall in much of the Pampas helps explain the lower rainfall recorded in the Western Pampas sub-regions in recent years. This has had a significant impact on agriculture and the environment.

  10. Dynamics of inner ear pressure change caused by intracranial pressure manipulation in the guinea pig

    NARCIS (Netherlands)

    Thalen, EO; Wit, HP; Segenhout, JM; Albers, FWJ

    Previous studies have shown that pressure changes in the cerebrospinal fluid compartment are transmitted to the inner ear. The main route for pressure transfer is the cochlear aqueduct, about which little is known with regard to its dynamic properties. In the present study, sudden intracranial

  11. Soil bulk density changes caused by mechanized harvesting: A case study in central Appalachia (United States)

    Jingxin Wang; Chris B. LeDoux; Pam Edwards; Mark Jones; Mark Jones


    A mechanized harvesting system consisting of a feller-buncher and a grapple skidder was examined to quantify soil bulk density changes in a central Appalachian hardwood forest site. Soil bulk density was measured using a nuclear gauge pre-harvest and post-harvest systematically across the harvest unit and on transects across skid trails. Bulk density also was measured...

  12. Influence of cataract surgery and blood pressure changes caused by sodium restriction on retinal vascular diameter

    Directory of Open Access Journals (Sweden)

    Takatoshi Tano


    Full Text Available Takatoshi Tano1, Yoshimune Hiratsuka2, Koichi Ono1, Akira Murakami11Department of Ophthalmology, Juntendo University School of Medicine, Tokyo; 2National Institute of Public Health, Tokyo, JapanPurpose: To investigate the impact of cataract surgery and blood pressure changes induced by one week of sodium restriction on retinal vascular diameter.Methods: Fundus photographs of 200 patients were obtained before and one week after cataract surgery. For one week after admission, 100 patients received sodium restriction and 100 patients (ie, the control group did not receive sodium restriction. The diameter of the retinal vessels and blood pressure were compared between the sodium restriction group and the control group. The vascular diameter was measured using an objective computer-based method.Results: Neither group had a significant change in the diameter of the retinal vessels after cataract surgery. Although there was no significant change in retinal arterial and venular diameter in the sodium restriction group, one-week sodium restriction significantly reduced mean blood pressure. However, multiple linear regression analyses indicated that an increase in retinal arteriolar diameter was significantly associated with diabetes, hyperlipidemia, and alcohol intake.Conclusion: Cataract surgery and blood pressure reduction induced by one week of sodium restriction resulted in no significant change in retinal arteriolar diameter.Keywords: cataract surgery, hypertension, retinal blood vessel diameter, retinal fundus camera, sodium restriction.

  13. Bioassay of body fluids, experiment M073. [biochemical changes caused by space flight conditions (United States)

    Leach, C. S.; Rambaut, P. C.


    Body fluids were assayed in this experiment to demonstrate changes which might have occurred during the 56-day chamber study in fluid and electrolyte balance, in regulation of calcium metabolism, in overall physiological and emotional adaptation to the environment, and in regulation of metabolic processes.

  14. Biofuels that cause land-use change may have much larger non-GHG air quality emissions than fossil fuels. (United States)

    Tsao, C-C; Campbell, J E; Mena-Carrasco, M; Spak, S N; Carmichael, G R; Chen, Y


    Although biofuels present an opportunity for renewable energy production, significant land-use change resulting from biofuels may contribute to negative environmental, economic, and social impacts. Here we examined non-GHG air pollution impacts from both indirect and direct land-use change caused by the anticipated expansion of Brazilian biofuels production. We synthesized information on fuel loading, combustion completeness, and emission factors, and developed a spatially explicit approach with uncertainty and sensitivity analyses to estimate air pollution emissions. The land-use change emissions, ranging from 6.7 to 26.4 Tg PM(2.5), were dominated by deforestation burning practices associated with indirect land-use change. We also found Brazilian sugar cane ethanol and soybean biodiesel including direct and indirect land-use change effects have much larger life-cycle emissions than conventional fossil fuels for six regulated air pollutants. The emissions magnitude and uncertainty decrease with longer life-cycle integration periods. Results are conditional to the single LUC scenario employed here. After LUC uncertainty, the largest source of uncertainty in LUC emissions stems from the combustion completeness during deforestation. While current biofuels cropland burning policies in Brazil seek to reduce life-cycle emissions, these policies do not address the large emissions caused by indirect land-use change.

  15. Predicting Binding Free Energy Change Caused by Point Mutations with Knowledge-Modified MM/PBSA Method.

    Directory of Open Access Journals (Sweden)

    Marharyta Petukh


    Full Text Available A new methodology termed Single Amino Acid Mutation based change in Binding free Energy (SAAMBE was developed to predict the changes of the binding free energy caused by mutations. The method utilizes 3D structures of the corresponding protein-protein complexes and takes advantage of both approaches: sequence- and structure-based methods. The method has two components: a MM/PBSA-based component, and an additional set of statistical terms delivered from statistical investigation of physico-chemical properties of protein complexes. While the approach is rigid body approach and does not explicitly consider plausible conformational changes caused by the binding, the effect of conformational changes, including changes away from binding interface, on electrostatics are mimicked with amino acid specific dielectric constants. This provides significant improvement of SAAMBE predictions as indicated by better match against experimentally determined binding free energy changes over 1300 mutations in 43 proteins. The final benchmarking resulted in a very good agreement with experimental data (correlation coefficient 0.624 while the algorithm being fast enough to allow for large-scale calculations (the average time is less than a minute per mutation.

  16. Hydrostatic pressure does not cause detectable changes in survival of human retinal ganglion cells.

    Directory of Open Access Journals (Sweden)

    Andrew Osborne

    Full Text Available PURPOSE: Elevated intraocular pressure (IOP is a major risk factor for glaucoma. One consequence of raised IOP is that ocular tissues are subjected to increased hydrostatic pressure (HP. The effect of raised HP on stress pathway signaling and retinal ganglion cell (RGC survival in the human retina was investigated. METHODS: A chamber was designed to expose cells to increased HP (constant and fluctuating. Accurate pressure control (10-100 mmHg was achieved using mass flow controllers. Human organotypic retinal cultures (HORCs from donor eyes (<24 h post mortem were cultured in serum-free DMEM/HamF12. Increased HP was compared to simulated ischemia (oxygen glucose deprivation, OGD. Cell death and apoptosis were measured by LDH and TUNEL assays, RGC marker expression by qRT-PCR (THY-1 and RGC number by immunohistochemistry (NeuN. Activated p38 and JNK were detected by Western blot. RESULTS: Exposure of HORCs to constant (60 mmHg or fluctuating (10-100 mmHg; 1 cycle/min pressure for 24 or 48 h caused no loss of structural integrity, LDH release, decrease in RGC marker expression (THY-1 or loss of RGCs compared with controls. In addition, there was no increase in TUNEL-positive NeuN-labelled cells at either time-point indicating no increase in apoptosis of RGCs. OGD increased apoptosis, reduced RGC marker expression and RGC number and caused elevated LDH release at 24 h. p38 and JNK phosphorylation remained unchanged in HORCs exposed to fluctuating pressure (10-100 mmHg; 1 cycle/min for 15, 30, 60 and 90 min durations, whereas OGD (3 h increased activation of p38 and JNK, remaining elevated for 90 min post-OGD. CONCLUSIONS: Directly applied HP had no detectable impact on RGC survival and stress-signalling in HORCs. Simulated ischemia, however, activated stress pathways and caused RGC death. These results show that direct HP does not cause degeneration of RGCs in the ex vivo human retina.

  17. Minimal change disease caused by exposure to mercury-containing skin lightening cream: a report of 4 cases. (United States)

    Tang, Hon-Lok; Mak, Yuen-Fun; Chu, Kwok-Hong; Lee, William; Fung, Samuel Kaâ Shun; Chan, Thomas Yan-Keung; Tong, Kwok-Lung


    Mercury is a known cause of nephrotic syndrome and the underlying renal pathology in most of the reported cases was membranous nephropathy. We describe here 4 cases of minimal change disease following exposure to mercury-containing skin lightening cream for 2 - 6 months. The mercury content of the facial creams was very high (7,420 - 30,000 parts per million). All patients were female and presented with nephrotic syndrome and heavy proteinuria (8.35 - 20.69 g/d). The blood and urine mercury levels were 26 - 129 nmol/l and 316 - 2,521 nmol/d, respectively. Renal biopsy revealed minimal change disease (MCD) in all patients. The use of cosmetic cream was stopped and chelation therapy with D-penicillamine was given. Two patients were also given steroids. The time for blood mercury level to normalize was 1 - 7 months, whereas it took longer for urine mercury level to normalize (9 - 16 months). All patients had complete remission of proteinuria and the time to normalization of proteinuria was 1 - 9 months. Mercury-containing skin lightening cream is hazardous because skin absorption of mercury can cause minimal change disease. The public should be warned of the danger of using such products. In patients presenting with nephrotic syndrome, a detailed history should be taken, including the use of skin lightening cream. With regard to renal pathology, apart from membranous nephropathy, minimal change disease should be included as another pathological entity caused by mercury exposure or intoxication.

  18. EYS Mutations Causing Autosomal Recessive Retinitis Pigmentosa: Changes of Retinal Structure and Function with Disease Progression

    Directory of Open Access Journals (Sweden)

    David B. McGuigan


    Full Text Available Mutations in the EYS (eyes shut homolog gene are a common cause of autosomal recessive (ar retinitis pigmentosa (RP. Without a mammalian model of human EYS disease, there is limited understanding of details of disease expression and rates of progression of the retinal degeneration. We studied clinically and with chromatic static perimetry, spectral-domain optical coherence tomography (OCT, and en face autofluoresence imaging, a cohort of 15 patients (ages 12–51 at first visit, some of whom had longitudinal data of function and structure. Rod sensitivity was able to be measured by chromatic perimetry in most patients at their earliest visits and some patients retained patchy rod function into the fifth decade of life. As expected from RP, cone sensitivity persisted after rod function was no longer measurable. The photoreceptor nuclear layer of the central retina was abnormal except at the fovea in most patients at first visit. Perifoveal disease measured over a period of years indicated that photoreceptor structural loss was followed by dysmorphology of the inner retina and loss of retinal pigment epithelial integrity. Although there could be variability in severity, preliminary analyses of the rates of vision loss suggested that EYS is a more rapidly progressive disease than other ciliopathies causing arRP, such as USH2A and MAK.

  19. Understanding Global Change: A New Conceptual Framework To Guide Teaching About Planetary Systems And Both The Causes And Effects Of Changes In Those Systems (United States)

    Levine, J.; Bean, J. R.


    Goals of the Next Generation Science Standards include understanding climate change and learning about ways to moderate the causes and mitigate the consequences of planetary-scale anthropogenic activities that interact synergistically to affect ecosystems and societies. The sheer number and scale of both causes and effects of global change can be daunting for teachers, and the lack of a clear conceptual framework for presenting this material usually leads educators (and textbooks) to present these phenomenon as a disjointed "laundry list." But an alternative approach is in the works. The Understanding Global Change web resource, currently under development at the UC Berkeley Museum of Paleontology, will provide educators with a conceptual framework, graphic models, lessons, and assessment templates for teaching NGSS-aligned, interdisciplinary, global change curricula. The core of this resource is an original informational graphic that presents and relates Earth's global systems, human and non-human factors that produce changes in those systems, and the effects of those changes that scientists can measure.

  20. Revelation of Causes of Colour Change in Beryllium-Treated Sapphires

    Institute of Scientific and Technical Information of China (English)

    Pichet Limsuwan; Siwaporn Meejoo; Asanee Somdee; Kheamrutai Thamaphat; Treedej Kittiauchawal; Atitaya Siripinyanond; Jurek Krzystck


    Blue sapphires are treated with Be in oxidizing atmosphere to change the blue colour into yellow. Untreated and Be-treated samples are examined using laser ablation inductively coupled-plasma-mass spectrometry (LA-ICP-MS), electron spin resonance (ESR) and ultraviolet-visible (UV-vis) spectroscopy. The results show that the yellow colouration in Be-heated blue sapphires is not due to Be diffusion from the surface of sapphire. Be behaves as a sole catalyst in this process. We find that the charge transfer between the ferrous (Fe2+) and ferric (Fe3+) is the reason of the colour change. The above conclusions are confirmed by ESR measurements to determine the connections between the Fe3+ ions before and after Be-treated heat treatments.

  1. Changes in the microstructure of compacted bentonite caused by heating and hydration

    Directory of Open Access Journals (Sweden)

    Villar M.V.


    Full Text Available Two twin 40-cm long columns of compacted FEBEX bentonite were tested in Teflon cells; water was supplied through the top surface of the columns and in one of them a heater was placed at the base and set to 100°C. The purpose of these tests was to simulate the behaviour of an engineered barrier in a radioactive waste repository and investigate the effect of the thermal gradient on saturation. In particular, changes in the pore size distribution and interlayer size have been investigated in this work. The thermal gradient had a strong influence on the water intake and distribution. Water content and dry density gradients persisted in the two columns after 12 years of testing. These changes gave place to the modification of the bentonite microstructure, overall increasing the microstructural void ratio and the proportion of adsorbed, interlayer water.

  2. Changes in adipose tissue cellular composition during obesity and aging as a cause of metabolic dysregulation. (United States)

    Martyniak, Kari; Masternak, Michal M


    Adipose tissue represents complex endocrine organ containing several different cellular populations including adipocytes, pre-adipocytes, mesenchymal stem cells, macrophages and lymphocytes. It is well establishing that these populations are not static but alter during obesity and aging. Changes in cellular populations alter inflammatory status and other common metabolic complications arise, therefore adipose tissue cellular composition helps dictate its endocrine and regulatory function. During excessive weight gain in obese individuals and as we age there is shift towards increase populations of inflammatory macrophages with a decrease of regulatory T cell. This altered cellular composition promote chronic low grade inflammation negatively affecting mesenchymal stem cell progenitor self-renewal, which result in deterioration of adipogenesis and increased cellular stress in adipocytes. All these changes promote metabolic disorders including age- or obese-related insulin resistance leading to type 2 diabetes. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Changes in permeability caused by transient stresses: field observations, experiments, and mechanisms (United States)

    Manga, Michael; Beresnev, Igor; Brodsky, Emily E.; Elkhoury, Jean E.; Elsworth, Derek; Ingebritsen, Steve E.; Mays, David C.; Wang, Chi-yuen


    Oscillations in stress, such as those created by earthquakes, can increase permeability and fluid mobility in geologic media. In natural systems, strain amplitudes as small as 10–6 can increase discharge in streams and springs, change the water level in wells, and enhance production from petroleum reservoirs. Enhanced permeability typically recovers to prestimulated values over a period of months to years. Mechanisms that can change permeability at such small stresses include unblocking pores, either by breaking up permeability-limiting colloidal deposits or by mobilizing droplets and bubbles trapped in pores by capillary forces. The recovery time over which permeability returns to the prestimulated value is governed by the time to reblock pores, or for geochemical processes to seal pores. Monitoring permeability in geothermal systems where there is abundant seismicity, and the response of flow to local and regional earthquakes, would help test some of the proposed mechanisms and identify controls on permeability and its evolution.

  4. Recent morphological changes of the Yellow River (Huanghe) submerged delta: Causes and environmental implications (United States)

    Jiang, Chao; Pan, Shunqi; Chen, Shenliang


    The Yellow River (Huanghe) submerged delta (YRSD) has been under the threat of erosion and retreat during the Anthropocene due to dramatic climatic and anthropogenic changes in the Yellow River basin. The analysis of field data shows that over the period of 1977-2005, the changes in climate (decrease in precipitation and increase in air temperature) and human interventions (increase in water diversion projects) throughout the watershed have resulted in the sharp reductions of river flow and sediment discharges into the Bohai Sea. Consequently, over the decadal timescale, morphological evolution of the YRSD has gone through three stages: i.e. rapid accumulation (5.77 × 108 m3/year) in 1977-1985, moderate accumulation (3.80 × 108 m3/year) in 1986-1995 and slow accumulation (0.91 × 108 m3/year) in 1996-2005. Climatic change within the catchment characterized by the rapid increase of air temperature contributed significantly to the transitions from the rapid accumulation to the moderate accumulation, and to the subsequent slow accumulation. The decadal morphological changes of the YRSD also show peculiar deposition/erosion characteristics over the medium timescale under river input reduction. Within the three decades, the patterns of the main sedimentary body exhibit irregular ellipses with the long axis parallel to the - 5 or - 10 m isobaths and short axis perpendicular to the isobaths. The depocentres of the YRSD are located between the - 10 and - 15 m isobaths close to the respective river mouths, with a high vertical accretion rate of 1.20 m/year. The time series data of annual volumetric change of the YRSD and river sediment load from 1977 to 2005 further demonstrate significant linear positive relationships between deltaic geomorphic change and fluvial input over shorter timescales (annual and 3-year). The critical sediment discharges for maintaining the deposition/erosion equilibrium state of the YRSD over the annual and 3-year timescales are found to be 1

  5. A method to determine the ionization efficiency change of peptides caused by phosphorylation. (United States)

    Gao, Yuan; Wang, Yinsheng


    Quantitative assessment of post-translational modifications in proteins by mass spectrometry often requires the consideration of the alteration in ionization efficiency of peptides induced by the modification. Herein, we introduced a method to measure the relative ionization efficiencies of peptides using specifically designed unlabeled peptides. In our design, the peptide under study, in either the unmodified or modified form, is linked with an internal standard peptide via an enzyme cleavage site; thus, after enzymatic digestion, we could obtain readily a 1:1 ratio between the peptide under investigation and the internal standard peptide. The relative ionization efficiencies of the modified and unmodified peptides can then be calculated from the modification-induced change in the ratio of relative abundances of the ion of the peptide of interest over that of the internal standard peptide. We demonstrated the usefulness of the method by assessing the change in ionization efficiencies of four peptides introduced by phosphorylation.

  6. Composition-volume changes during hydrothermal alteration of andesite at Buttercup Hill, Noranda District, Quebec (United States)

    Lesher, C. M.; Gibson, H. L.; Campbell, I. H.


    hydrothermal modification of the andesite. Mass balance calculations suggest that volume was conserved during epidotization-silicification and albitization-silicification, but that intense silicification was accompanied by volume increases up to 30 percent.


    Directory of Open Access Journals (Sweden)

    E. Panidi


    Full Text Available The study is devoted to the investigation of regional climate change in Northern Russia. Due to sparseness of the meteorological observation network in northern regions, we investigate the application capabilities of remotely sensed vegetation cover as indicator of climate change at the regional scale. In previous studies, we identified statistically significant relationship between the increase of surface air temperature and increase of the shrub vegetation productivity. We verified this relationship using ground observation data collected at the meteorological stations and Normalised Difference Vegetation Index (NDVI data produced from Terra/MODIS satellite imagery. Additionally, we designed the technique of growing seasons separation for detailed investigation of the land cover (shrub cover dynamics. Growing seasons are the periods when the temperature exceeds +5°C and +10°C. These periods determine the vegetation productivity conditions (i.e., conditions that allow growth of the phytomass. We have discovered that the trend signs for the surface air temperature and NDVI coincide on planes and river floodplains. On the current stage of the study, we are working on the automated mapping technique, which allows to estimate the direction and magnitude of the climate change in Northern Russia. This technique will make it possible to extrapolate identified relationship between land cover and climate onto territories with sparse network of meteorological stations. We have produced the gridded maps of NDVI and NDWI for the test area in European part of Northern Russia covered with the shrub vegetation. Basing on these maps, we may determine the frames of growing seasons for each grid cell. It will help us to obtain gridded maps of the NDVI linear trend for growing seasons on cell-by-cell basis. The trend maps can be used as indicative maps for estimation of the climate change on the studied areas.

  8. Portfolio Sensitivity Model for Analyzing Credit Risk Caused by Structural and Macroeconomic Changes

    Directory of Open Access Journals (Sweden)

    Goran Klepac


    Full Text Available This paper proposes a new model for portfolio sensitivity analysis. The model is suitable for decision support in financial institutions, specifically for portfolio planning and portfolio management. The basic advantage of the model is the ability to create simulations for credit risk predictions in cases when we virtually change portfolio structure and/or macroeconomic factors. The model takes a holistic approach to portfolio management consolidating all organizational segments in the process such as marketing, retail and risk.

  9. [Atrial fibrillation as consequence and cause of structural changes of atria]. (United States)

    Aparina, O P; Chikhireva, L N; Stukalova, O V; Mironova, N A; Kashtanova, S Iu; Ternovoĭ, S K; Golitsyn, S P


    Changes of atrial structure and function are the contributors of atrial fibrillation clinical course, complications and treatment effectiveness. Effects of inflammation and mechanical stretch on atrial structural remodeling leading to atrial fibrillation are reviewed in the article. Contemporary invasive and non-invasive methods of evaluation (including late gadolinium enhancement magnetic resonance imaging) of patients with atrial structural remodeling in atrial fibrillation are also described.

  10. Cell dialysis by sharp electrodes can cause nonphysiological changes in neuron properties. (United States)

    Hooper, Scott L; Thuma, Jeffrey B; Guschlbauer, Christoph; Schmidt, Joachim; Büschges, Ansgar


    We recorded from lobster and leech neurons with two sharp electrodes filled with solutions often used with these preparations (lobster: 0.6 M K2SO4 or 2.5 M KAc; leech: 4 M KAc), with solutions approximately matching neuron cytoplasm ion concentrations, and with 6.5 M KAc (lobster, leech) and 0.6 M KAc (lobster). We measured membrane potential, input resistance, and transient and sustained depolarization-activated outward current amplitudes in leech and these neuron properties and hyperpolarization-activated current time constant in lobster, every 10 min for 60 min after electrode penetration. Neuron properties varied with electrode fill. For fills with molarities ≥2.5 M, neuron properties also varied strongly with time after electrode penetration. Depending on the property being examined, these variations could be large. In leech, cell size also increased with noncytoplasmic fills. The changes in neuron properties could be due to the ions being injected from the electrodes during current injection. We tested this possibility in lobster with the 2.5 M KAc electrode fill by making measurements only 10 and 60 min after penetration. Neuron properties still changed, although the changes were less extreme. Making measurements every 2 min showed that the time-dependent variations in neuron properties occurred in concert with each other. Neuron property changes with high molarity electrode-fill solutions were great enough to decrease neuron firing strongly. An experiment with (14)C-glucose electrode fill confirmed earlier work showing substantial leak from sharp electrodes. Sharp electrode work should thus be performed with cytoplasm-matched electrode fills.

  11. Global climate change: Causes, phenomena, consequences; Globale Klimaaenderungen - Ursachen, Phaenomene und Folgen