The average free volume model for liquids
Yu, Yang
2014-01-01
In this work, the molar volume thermal expansion coefficient of 59 room temperature ionic liquids is compared with their van der Waals volume Vw. Regular correlation can be discerned between the two quantities. An average free volume model, that considers the particles as hard core with attractive force, is proposed to explain the correlation in this study. A combination between free volume and Lennard-Jones potential is applied to explain the physical phenomena of liquids. Some typical simple liquids (inorganic, organic, metallic and salt) are introduced to verify this hypothesis. Good agreement from the theory prediction and experimental data can be obtained.
Medicare Part B Drug Average Sales Pricing Files
U.S. Department of Health & Human Services — Manufacturer reporting of Average Sales Price (ASP) data - A manufacturers ASP must be calculated by the manufacturer every calendar quarter and submitted to CMS...
Volume calculation of the spur gear billet for cold precision forging with average circle method
Institute of Scientific and Technical Information of China (English)
Wangjun Cheng; Chengzhong Chi; Yongzhen Wang; Peng Lin; Wei Liang; Chen Li
2014-01-01
Forging spur gears are widely used in the driving system of mining machinery and equipment due to their higher strength and dimensional accuracy. For the purpose of precisely calculating the volume of cylindrical spur gear billet in cold precision forging, a new theoretical method named average circle method was put forward. With this method, a series of gear billet volumes were calculated. Comparing with the accurate three-dimensional modeling method, the accuracy of average circle method by theoretical calculation was estimated and the maximum relative error of average circle method was less than 1.5%, which was in good agreement with the experimental results. Relative errors of the calculated and the experimental for obtaining the gear billet volumes with reference circle method are larger than those of the average circle method. It shows that average circle method possesses a higher calculation accuracy than reference circle method (traditional method), which should be worth popularizing widely in calculation of spur gear billet volume.
2010-09-03
... Average Manufacturer Price, Multiple Source Drug Definition, and Upper Limits for Multiple Source Drugs... the statutory definition of `average manufacturer price' or the statutory definition of `multiple... provisions we are proposing to withdraw are as follows: The determination of average manufacturer price (AMP...
Belo, Luciana Rodrigues; Gomes, Nathália Angelina Costa; Coriolano, Maria das Graças Wanderley de Sales; de Souza, Elizabete Santos; Moura, Danielle Albuquerque Alves; Asano, Amdore Guescel; Lins, Otávio Gomes
2014-08-01
The goal of this study was to obtain the limit of dysphagia and the average volume per swallow in patients with mild to moderate Parkinson's disease (PD) but without swallowing complaints and in normal subjects, and to investigate the relationship between them. We hypothesize there is a direct relationship between these two measurements. The study included 10 patients with idiopathic PD and 10 age-matched normal controls. Surface electromyography was recorded over the suprahyoid muscle group. The limit of dysphagia was obtained by offering increasing volumes of water until piecemeal deglutition occurred. The average volume per swallow was calculated by dividing the time taken by the number of swallows used to drink 100 ml of water. The PD group showed a significantly lower dysphagia limit and lower average volume per swallow. There was a significantly moderate direct correlation and association between the two measurements. About half of the PD patients had an abnormally low dysphagia limit and average volume per swallow, although none had spontaneously related swallowing problems. Both measurements may be used as a quick objective screening test for the early identification of swallowing alterations that may lead to dysphagia in PD patients, but the determination of the average volume per swallow is much quicker and simpler.
A Derivation of the Nonlocal Volume-Averaged Equations for Two-Phase Flow Transport
Directory of Open Access Journals (Sweden)
Gilberto Espinosa-Paredes
2012-01-01
Full Text Available In this paper a detailed derivation of the general transport equations for two-phase systems using a method based on nonlocal volume averaging is presented. The local volume averaging equations are commonly applied in nuclear reactor system for optimal design and safe operation. Unfortunately, these equations are limited to length-scale restriction and according with the theory of the averaging volume method, these fail in transition of the flow patterns and boundaries between two-phase flow and solid, which produce rapid changes in the physical properties and void fraction. The non-local volume averaging equations derived in this work contain new terms related with non-local transport effects due to accumulation, convection diffusion and transport properties for two-phase flow; for instance, they can be applied in the boundary between a two-phase flow and a solid phase, or in the boundary of the transition region of two-phase flows where the local volume averaging equations fail.
Derivation of a volume-averaged neutron diffusion equation; Atomos para el desarrollo de Mexico
Energy Technology Data Exchange (ETDEWEB)
Vazquez R, R.; Espinosa P, G. [UAM-Iztapalapa, Av. San Rafael Atlixco 186, Col. Vicentina, Mexico D.F. 09340 (Mexico); Morales S, Jaime B. [UNAM, Laboratorio de Analisis en Ingenieria de Reactores Nucleares, Paseo Cuauhnahuac 8532, Jiutepec, Morelos 62550 (Mexico)]. e-mail: rvr@xanum.uam.mx
2008-07-01
This paper presents a general theoretical analysis of the problem of neutron motion in a nuclear reactor, where large variations on neutron cross sections normally preclude the use of the classical neutron diffusion equation. A volume-averaged neutron diffusion equation is derived which includes correction terms to diffusion and nuclear reaction effects. A method is presented to determine closure-relationships for the volume-averaged neutron diffusion equation (e.g., effective neutron diffusivity). In order to describe the distribution of neutrons in a highly heterogeneous configuration, it was necessary to extend the classical neutron diffusion equation. Thus, the volume averaged diffusion equation include two corrections factor: the first correction is related with the absorption process of the neutron and the second correction is a contribution to the neutron diffusion, both parameters are related to neutron effects on the interface of a heterogeneous configuration. (Author)
Lattice Boltzmann Model for The Volume-Averaged Navier-Stokes Equations
Zhang, Jingfeng; Ouyang, Jie
2014-01-01
A numerical method, based on discrete lattice Boltzmann equation, is presented for solving the volume-averaged Navier-Stokes equations. With a modified equilibrium distribution and an additional forcing term, the volume-averaged Navier-Stokes equations can be recovered from the lattice Boltzmann equation in the limit of small Mach number by the Chapman-Enskog analysis and Taylor expansion. Due to its advantages such as explicit solver and inherent parallelism, the method appears to be more competitive with traditional numerical techniques. Numerical simulations show that the proposed model can accurately reproduce both the linear and nonlinear drag effects of porosity in the fluid flow through porous media.
The average free volume model for the ionic and simple liquids
Yu, Yang
2014-01-01
In this work, the molar volume thermal expansion coefficient of 60 room temperature ionic liquids is compared with their van der Waals volume Vw. Regular correlation can be discerned between the two quantities. An average free volume model, that considers the particles as hard core with attractive force, is proposed to explain the correlation in this study. Some typical one atom liquids (molten metals and liquid noble gases) are introduced to verify this hypothesis. Good agreement between the theory prediction and experimental data can be obtained.
An Ecological Analysis of Peer Influence on Adolescent Grade Point Average and Drug Use.
Mounts, Nina S.; Steinberg, Laurence
1995-01-01
Examined interactive effects of peer behavior and adolescents' perceptions of authoritative parenting on grade point average and drug use among adolescents. Found that changes in GPA and drug use were predicted by friends' grades and drug use, although this effect was moderated by perceptions of authoritative parenting. (HTH)
Volume Averaging Theory (VAT) based modeling and closure evaluation for fin-and-tube heat exchangers
Zhou, Feng; Catton, Ivan
2012-10-01
A fin-and-tube heat exchanger was modeled based on Volume Averaging Theory (VAT) in such a way that the details of the original structure was replaced by their averaged counterparts, so that the VAT based governing equations can be efficiently solved for a wide range of parameters. To complete the VAT based model, proper closure is needed, which is related to a local friction factor and a heat transfer coefficient of a Representative Elementary Volume (REV). The terms in the closure expressions are complex and sometimes relating experimental data to the closure terms is difficult. In this work we use CFD to evaluate the rigorously derived closure terms over one of the selected REVs. The objective is to show how heat exchangers can be modeled as a porous media and how CFD can be used in place of a detailed, often formidable, experimental effort to obtain closure for the model.
2010-11-15
... of Average Manufacturer Price, Multiple Source Drug Definition, and Upper Limits for Multiple Source....502 ``Definitions'' was intended to apply to both AMP and best price calculations. While the... Determination of Best Price (Sec. 447.505). Therefore, we see no need to withdraw the definition of bona fide...
Use of unbound volumes of drug distribution in pharmacokinetic calculations.
Stepensky, David
2011-01-18
Volume of drug distribution is a primary pharmacokinetic parameter. This study assessed effects of drugs' plasma protein binding and tissue distribution on volume of drug distribution and identified the most appropriate ways for its calculation. Effects of the distribution factors on the unbound and total drug plasma concentrations and on the corresponding volumes of distribution were studied using pharmacokinetic modeling and simulation approach based on in vitro and in vivo concentration vs. time data of diazepam, a model drug with extensive plasma protein binding and tissue distribution. Pharmacokinetics of diazepam were appropriately described by three-compartment pharmacokinetic model that incorporated the processes of plasma protein binding and tissue permeation. According to this model, displacement of the drug from plasma proteins increases the unbound (but not the total) plasma concentrations and induces faster drug elimination from the body. The distribution pattern of the drug in the body and the time course of unbound (pharmacologically active) drug concentrations correlated with the unbound volumes of distribution, but not with the total volumes of distribution. In conclusion, unbound volumes of distribution appropriately describe the drug distribution pattern and the time course of unbound drug concentrations and are recommended for use as primary pharmacokinetic parameters in pharmaceutical research. Copyright © 2010 Elsevier B.V. All rights reserved.
Davit, Yohan
2013-12-01
A wide variety of techniques have been developed to homogenize transport equations in multiscale and multiphase systems. This has yielded a rich and diverse field, but has also resulted in the emergence of isolated scientific communities and disconnected bodies of literature. Here, our goal is to bridge the gap between formal multiscale asymptotics and the volume averaging theory. We illustrate the methodologies via a simple example application describing a parabolic transport problem and, in so doing, compare their respective advantages/disadvantages from a practical point of view. This paper is also intended as a pedagogical guide and may be viewed as a tutorial for graduate students as we provide historical context, detail subtle points with great care, and reference many fundamental works. © 2013 Elsevier Ltd.
Measurement of average density and relative volumes in a dispersed two-phase fluid
Sreepada, Sastry R.; Rippel, Robert R.
1992-01-01
An apparatus and a method are disclosed for measuring the average density and relative volumes in an essentially transparent, dispersed two-phase fluid. A laser beam with a diameter no greater than 1% of the diameter of the bubbles, droplets, or particles of the dispersed phase is directed onto a diffraction grating. A single-order component of the diffracted beam is directed through the two-phase fluid and its refraction is measured. Preferably, the refracted beam exiting the fluid is incident upon a optical filter with linearly varing optical density and the intensity of the filtered beam is measured. The invention can be combined with other laser-based measurement systems, e.g., laser doppler anemometry.
Berezhkovskii, Alexander M.; Weiss, George H.
1996-07-01
In order to extend the greatly simplified Smoluchowski model for chemical reaction rates it is necessary to incorporate many-body effects. A generalization with this feature is the so-called trapping model in which random walkers move among a uniformly distributed set of traps. The solution of this model requires consideration of the distinct number of sites visited by a single n-step random walk. A recent analysis [H. Larralde et al., Phys. Rev. A 45, 1728 (1992)] has considered a generalized version of this problem by calculating the average number of distinct sites visited by N n-step random walks. A related continuum analysis is given in [A. M. Berezhkovskii, J. Stat. Phys. 76, 1089 (1994)]. We consider a slightly different version of the general problem by calculating the average volume of the Wiener sausage generated by Brownian particles generated randomly in time. The analysis shows that two types of behavior are possible: one in which there is strong overlap between the Wiener sausages of the particles, and the second in which the particles are mainly independent of one another. Either one or both of these regimes occur, depending on the dimension.
Directory of Open Access Journals (Sweden)
H. Matsueda
2010-02-01
Full Text Available Column-averaged volume mixing ratios of carbon dioxide (XCO2 during the period from January 2007 to May 2008 over Tsukuba, Japan, were derived by using CO2 concentration data observed by Japan Airlines Corporation (JAL commercial airliners, based on the assumption that CO2 profiles over Tsukuba and Narita were the same. CO2 profile data for 493 flights on clear-sky days were analysed in order to calculate XCO2 with an ancillary dataset: Tsukuba observational data (by rawinsonde and a meteorological tower or global meteorological data (NCEP and CIRA-86. The amplitude of seasonal variation of XCO2 (Tsukuba observational from the Tsukuba observational data was determined by least-squares fit using a harmonic function to roughly evaluate the seasonal variation over Tsukuba. The highest and lowest values of the obtained fitted curve in 2007 for XCO2 (Tsukuba observational were 386.4 and 381.7 ppm in May and September, respectively. The dependence of XCO2 on the type of ancillary dataset was evaluated. The average difference between XCO2 (global from global climatological data and XCO2 (Tsukuba observational, i.e., the bias of XCO2 (global based on XCO2 (Tsukuba observational, was found to be -0.621 ppm with a standard deviation of 0.682 ppm. The uncertainty of XCO2 (global based on XCO2 (Tsukuba observational was estimated to be 0.922 ppm. This small uncertainty suggests that the present method of XCO2 calculation using data from airliners and global climatological data can be applied to the validation of GOSAT products for XCO2 over airports worldwide.
Energy Technology Data Exchange (ETDEWEB)
Espinosa-Paredes, Gilberto, E-mail: gepe@xanum.uam.m [Area de Ingenieria en Recursos Energeticos, Universidad Autonoma Metropolitana-Iztapalapa, Av. San Rafael Atlixco 186, Col. Vicentina, Apartado Postal 55-535, Mexico D.F. 09340 (Mexico)
2010-05-15
The aim of this paper is to propose a framework to obtain a new formulation for multiphase flow conservation equations without length-scale restrictions, based on the non-local form of the averaged volume conservation equations. The simplification of the local averaging volume of the conservation equations to obtain practical equations is subject to the following length-scale restrictions: d << l << L, where d is the characteristic length of the dispersed phases, l is the characteristic length of the averaging volume, and L is the characteristic length of the physical system. If the foregoing inequality does not hold, or if the scale of the problem of interest is of the order of l, the averaging technique and therefore, the macroscopic theories of multiphase flow should be modified in order to include appropriate considerations and terms in the corresponding equations. In these cases the local form of the averaged volume conservation equations are not appropriate to describe the multiphase system. As an example of the conservation equations without length-scale restrictions, the natural circulation boiling water reactor was consider to study the non-local effects on the thermal-hydraulic core performance during steady-state and transient behaviors, and the results were compared with the classic local averaging volume conservation equations.
Park, Sun-Young; Han, Euna; Kim, Jini; Lee, Eui-Kyung
2016-08-01
This study analyzed factors contributing to increases in the actual sales volumes relative to forecasted volumes of drugs under price-volume agreement (PVA) policy in South Korea. Sales volumes of newly listed drugs on the national formulary are monitored under PVA policy. When actual sales volume exceeds the pre-agreed forecasted volume by 30% or more, the drug is subject to price-reduction. Logistic regression assessed the factors related to whether drugs were the PVA price-reduction drugs. A generalized linear model with gamma distribution and log-link assessed the factors influencing the increase in actual volumes compared to forecasted volume in the PVA price-reduction drugs. Of 186 PVA monitored drugs, 34.9% were price-reduction drugs. Drugs marketed by pharmaceutical companies with previous-occupation in the therapeutic markets were more likely to be PVA price-reduction drugs than drugs marketed by firms with no previous-occupation. Drugs of multinational pharmaceutical companies were more likely to be PVA price-reduction drugs than those of domestic companies. Having more alternative existing drugs was significantly associated with higher odds of being PVA price-reduction drugs. Among the PVA price-reduction drugs, the increasing rate of actual volume compared to forecasted volume was significantly higher in drugs with clinical usefulness. By focusing the negotiation efforts on those target drugs, PVA policy can be administered more efficiently with the improved predictability of the drug sales volumes. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
Kabala, Z. J.
1997-08-01
Under the assumption that local solute dispersion is negligible, a new general formula (in the form of a convolution integral) is found for the arbitrary k-point ensemble moment of the local concentration of a solute convected in arbitrary m spatial dimensions with general sure initial conditions. From this general formula new closed-form solutions in m=2 spatial dimensions are derived for 2-point ensemble moments of the local solute concentration for the impulse (Dirac delta) and Gaussian initial conditions. When integrated over an averaging window, these solutions lead to new closed-form expressions for the first two ensemble moments of the volume-averaged solute concentration and to the corresponding concentration coefficients of variation (CV). Also, for the impulse (Dirac delta) solute concentration initial condition, the second ensemble moment of the solute point concentration in two spatial dimensions and the corresponding CV are demonstrated to be unbound. For impulse initial conditions the CVs for volume-averaged concentrations axe compared with each other for a tracer from the Borden aquifer experiment. The point-concentration CV is unacceptably large in the whole domain, implying that the ensemble mean concentration is inappropriate for predicting the actual concentration values. The volume-averaged concentration CV decreases significantly with an increasing averaging volume. Since local dispersion is neglected, the new solutions should be interpreted as upper limits for the yet to be derived solutions that account for local dispersion; and so should the presented CVs for Borden tracers. The new analytical solutions may be used to test the accuracy of Monte Carlo simulations or other numerical algorithms that deal with the stochastic solute transport. They may also be used to determine the size of the averaging volume needed to make a quasi-sure statement about the solute mass contained in it.
Chen, Chieh-Fan; Ho, Wen-Hsien; Chou, Huei-Yin; Yang, Shu-Mei; Chen, I-Te; Shi, Hon-Yi
2011-01-01
This study analyzed meteorological, clinical and economic factors in terms of their effects on monthly ED revenue and visitor volume. Monthly data from January 1, 2005 to September 30, 2009 were analyzed. Spearman correlation and cross-correlation analyses were performed to identify the correlation between each independent variable, ED revenue, and visitor volume. Autoregressive integrated moving average (ARIMA) model was used to quantify the relationship between each independent variable, ED revenue, and visitor volume. The accuracies were evaluated by comparing model forecasts to actual values with mean absolute percentage of error. Sensitivity of prediction errors to model training time was also evaluated. The ARIMA models indicated that mean maximum temperature, relative humidity, rainfall, non-trauma, and trauma visits may correlate positively with ED revenue, but mean minimum temperature may correlate negatively with ED revenue. Moreover, mean minimum temperature and stock market index fluctuation may correlate positively with trauma visitor volume. Mean maximum temperature, relative humidity and stock market index fluctuation may correlate positively with non-trauma visitor volume. Mean maximum temperature and relative humidity may correlate positively with pediatric visitor volume, but mean minimum temperature may correlate negatively with pediatric visitor volume. The model also performed well in forecasting revenue and visitor volume.
Directory of Open Access Journals (Sweden)
Chieh-Fan Chen
2011-01-01
Full Text Available This study analyzed meteorological, clinical and economic factors in terms of their effects on monthly ED revenue and visitor volume. Monthly data from January 1, 2005 to September 30, 2009 were analyzed. Spearman correlation and cross-correlation analyses were performed to identify the correlation between each independent variable, ED revenue, and visitor volume. Autoregressive integrated moving average (ARIMA model was used to quantify the relationship between each independent variable, ED revenue, and visitor volume. The accuracies were evaluated by comparing model forecasts to actual values with mean absolute percentage of error. Sensitivity of prediction errors to model training time was also evaluated. The ARIMA models indicated that mean maximum temperature, relative humidity, rainfall, non-trauma, and trauma visits may correlate positively with ED revenue, but mean minimum temperature may correlate negatively with ED revenue. Moreover, mean minimum temperature and stock market index fluctuation may correlate positively with trauma visitor volume. Mean maximum temperature, relative humidity and stock market index fluctuation may correlate positively with non-trauma visitor volume. Mean maximum temperature and relative humidity may correlate positively with pediatric visitor volume, but mean minimum temperature may correlate negatively with pediatric visitor volume. The model also performed well in forecasting revenue and visitor volume.
Drug and Alcohol Studies (Volume 4: Policy approaches)
Macgregor, S.; Thom, B
2014-01-01
VOLUME FOUR: POLICY APPROACHES Preface Robert MacCoun and Peter Reuter The Varieties of Drug Control at the Dawn of the 21st Century Comparative Analysis of Alcohol Control Policies in 30 Countries Donald Brand et al A Comparative Study of 38 European Countries Limited Rationality and the Limits of Supply Reduction Jonathan Caulkins and Robert MacCoun The Limited Relevance of Drug Policy Craig Reinerman, Peter Cohen and Hendrien Kaal Cannabis in Amsterdam and San Francisco AIDS and Injecting ...
Kováčik, L; Kereïche, S; Matula, P; Raška, I
2014-01-01
Electron tomographic reconstructions suffer from a number of artefacts arising from effects accompanying the processes of acquisition of a set of tilted projections of the specimen in a transmission electron microscope and from its subsequent computational handling. The most pronounced artefacts usually come from imprecise projection alignment, distortion of specimens during tomogram acquisition and from the presence of a region of missing data in the Fourier space, the "missing wedge". The ray artefacts caused by the presence of the missing wedge can be attenuated by the angular image filter, which attenuates the transition between the data and the missing wedge regions. In this work, we present an analysis of the influence of angular filtering on the resolution of averaged repetitive structural motives extracted from three-dimensional reconstructions of tomograms acquired in the single-axis tilting geometry.
Volume-Averaged Model of Inductively-Driven Multicusp Ion Source
Patel, Kedar K.; Lieberman, M. A.; Graf, M. A.
1998-10-01
A self-consistent spatially averaged model of high-density oxygen and boron trifluoride discharges has been developed for a 13.56 MHz, inductively coupled multicusp ion source. We determine positive ion, negative ion, and electron densities, the ground state and metastable densities, and the electron temperature as functions of the control parameters: gas pressure, gas flow rate, input power and reactor geometry. Neutralization and fragmentation into atomic species are assumed for all ions hitting the wall. For neutrals, a wall recombination coefficient for oxygen atoms and a wall sticking coefficient for boron trifluoride (BF_3) and its dissociation products are the single adjustable parameters used to model the surface chemistry. For the aluminum walls of the ion source used in the Eaton ULE2 ion implanter, complete wall recombination of O atoms is found to give the best match to the experimental data for oxygen, whereas a sticking coefficient of 0.62 for all neutral species in a BF3 discharge was found to best match experimental data.
Barraclough, Brendan; Li, Jonathan G.; Lebron, Sharon; Fan, Qiyong; Liu, Chihray; Yan, Guanghua
2015-08-01
The ionization chamber volume averaging effect is a well-known issue without an elegant solution. The purpose of this study is to propose a novel convolution-based approach to address the volume averaging effect in model-based treatment planning systems (TPSs). Ionization chamber-measured beam profiles can be regarded as the convolution between the detector response function and the implicit real profiles. Existing approaches address the issue by trying to remove the volume averaging effect from the measurement. In contrast, our proposed method imports the measured profiles directly into the TPS and addresses the problem by reoptimizing pertinent parameters of the TPS beam model. In the iterative beam modeling process, the TPS-calculated beam profiles are convolved with the same detector response function. Beam model parameters responsible for the penumbra are optimized to drive the convolved profiles to match the measured profiles. Since the convolved and the measured profiles are subject to identical volume averaging effect, the calculated profiles match the real profiles when the optimization converges. The method was applied to reoptimize a CC13 beam model commissioned with profiles measured with a standard ionization chamber (Scanditronix Wellhofer, Bartlett, TN). The reoptimized beam model was validated by comparing the TPS-calculated profiles with diode-measured profiles. Its performance in intensity-modulated radiation therapy (IMRT) quality assurance (QA) for ten head-and-neck patients was compared with the CC13 beam model and a clinical beam model (manually optimized, clinically proven) using standard Gamma comparisons. The beam profiles calculated with the reoptimized beam model showed excellent agreement with diode measurement at all measured geometries. Performance of the reoptimized beam model was comparable with that of the clinical beam model in IMRT QA. The average passing rates using the reoptimized beam model increased substantially from 92.1% to
Can higher prices increase market share? Average wholesale prices and Medicaid drug procurement
National Research Council Canada - National Science Library
Fitzgerald, Jay
2014-01-01
..., generic drug manufacturers have an incentive to compete for pharmacy market share by driving up the prices paid to pharmacies by Medicaid. The authors report that a federal government crackdown on Medicaid pricing practices in 2000 led to a 45 percent decrease in the Medicaid market share of the drugs tar geted by the crackdown, which were generic...
Davit, Barbara M; Chen, Mei-Ling; Conner, Dale P; Haidar, Sam H; Kim, Stephanie; Lee, Christina H; Lionberger, Robert A; Makhlouf, Fairouz T; Nwakama, Patrick E; Patel, Devvrat T; Schuirmann, Donald J; Yu, Lawrence X
2012-12-01
Highly variable (HV) drugs are defined as those for which within-subject variability (%CV) in bioequivalence (BE) measures is 30% or greater. Because of this high variability, studies designed to show whether generic HV drugs are bioequivalent to their corresponding HV reference drugs may need to enroll large numbers of subjects even when the products have no significant mean differences. To avoid unnecessary human testing, the US Food and Drug Administration's Office of Generic Drugs developed a reference-scaled average bioequivalence (RSABE) approach, whereby the BE acceptance limits are scaled to the variability of the reference product. For an acceptable RSABE study, an HV generic drug product must meet the scaled BE limit and a point estimate constraint. The approach has been implemented successfully. To date, the RSABE approach has supported four full approvals and one tentative approval of HV generic drug products.
2010-11-15
This final rule withdraws two provisions from the "Medicaid Program; Prescription Drugs'' final rule (referred to hereafter as "AMP final rule") published in the July 17, 2007 Federal Register. The provisions we are withdrawing are as follows: The determination of average manufacturer price, and the Federal upper limits for multiple source drugs. We are also withdrawing the definition of "multiple source drug" as it was revised in the ``Medicaid Program; Multiple Source Drug Definition'' final rule published in the October 7, 2008 Federal Register.
Directory of Open Access Journals (Sweden)
Björn eNitzsche
2015-06-01
Full Text Available Standard stereotaxic reference systems play a key role in human brain studies. Stereotaxic coordinate systems have also been developed for experimental animals including non-human primates, dogs and rodents. However, they are lacking for other species being relevant in experimental neuroscience including sheep. Here, we present a spatial, unbiased ovine brain template with tissue probability maps (TPM that offer a detailed stereotaxic reference frame for anatomical features and localization of brain areas, thereby enabling inter-individual and cross-study comparability. Three-dimensional data sets from healthy adult Merino sheep (Ovis orientalis aries, 12 ewes and 26 neutered rams were acquired on a 1.5T Philips MRI using a T1w sequence. Data were averaged by linear and non-linear registration algorithms. Moreover, animals were subjected to detailed brain volume analysis including examinations with respect to body weight, age and sex. The created T1w brain template provides an appropriate population-averaged ovine brain anatomy in a spatial standard coordinate system. Additionally, TPM for gray (GM and white (WM matter as well as cerebrospinal fluid (CSF classification enabled automatic prior-based tissue segmentation using statistical parametric mapping (SPM. Overall, a positive correlation of GM volume and body weight explained about 15% of the variance of GM while a positive correlation between WM and age was found. Absolute tissue volume differences were not detected, indeed ewes showed significantly more GM per bodyweight as compared to neutered rams. The created framework including spatial brain template and TPM represent a useful tool for unbiased automatic image preprocessing and morphological characterization in sheep. Therefore, the reported results may serve as a starting point for further experimental and/or translational research aiming at in vivo analysis in this species.
Nitzsche, Björn; Frey, Stephen; Collins, Louis D; Seeger, Johannes; Lobsien, Donald; Dreyer, Antje; Kirsten, Holger; Stoffel, Michael H; Fonov, Vladimir S; Boltze, Johannes
2015-01-01
Standard stereotaxic reference systems play a key role in human brain studies. Stereotaxic coordinate systems have also been developed for experimental animals including non-human primates, dogs, and rodents. However, they are lacking for other species being relevant in experimental neuroscience including sheep. Here, we present a spatial, unbiased ovine brain template with tissue probability maps (TPM) that offer a detailed stereotaxic reference frame for anatomical features and localization of brain areas, thereby enabling inter-individual and cross-study comparability. Three-dimensional data sets from healthy adult Merino sheep (Ovis orientalis aries, 12 ewes and 26 neutered rams) were acquired on a 1.5 T Philips MRI using a T1w sequence. Data were averaged by linear and non-linear registration algorithms. Moreover, animals were subjected to detailed brain volume analysis including examinations with respect to body weight (BW), age, and sex. The created T1w brain template provides an appropriate population-averaged ovine brain anatomy in a spatial standard coordinate system. Additionally, TPM for gray (GM) and white (WM) matter as well as cerebrospinal fluid (CSF) classification enabled automatic prior-based tissue segmentation using statistical parametric mapping (SPM). Overall, a positive correlation of GM volume and BW explained about 15% of the variance of GM while a positive correlation between WM and age was found. Absolute tissue volume differences were not detected, indeed ewes showed significantly more GM per bodyweight as compared to neutered rams. The created framework including spatial brain template and TPM represent a useful tool for unbiased automatic image preprocessing and morphological characterization in sheep. Therefore, the reported results may serve as a starting point for further experimental and/or translational research aiming at in vivo analysis in this species.
Institute of Scientific and Technical Information of China (English)
T. Wang; B.Pustal; M. Abondano; T. Grimmig; A. B(u)hrig-Polaczek; M. Wu; A. Ludwig
2005-01-01
The cooling channel process is a rehocasting method by which the prematerial with globular microstructure can be produced to fit the thixocasting process. A three-phase model based on volume averaging approach is proposed to simulate the cooling channel process of A356 Aluminum alloy. The three phases are liquid, solid and air respectively and treated as separated and interacting continua, sharing a single pressure field. The mass, momentum, enthalpy transport equations for each phase are solved. The developed model can predict the evolution of liquid, solid and air fraction as well as the distribution of grain density and grain size. The effect of pouring temperature on the grain density, grain size and solid fraction is analyzed in detail.
Average Out-of-Pocket Expenses Across Different Drug Categories and Commercial Third-Party Payers
Lenderts, Susan; Kalali, Amir H.
2010-01-01
In this Trend Watch, we look at retail pharmacy prescriptions for branded and generic attention deficit hyperactivity disorder treatments, atypical antipsychotics, selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors and analyze the average out-of-pocket costs incurred by patients who are covered by commercial third-party prescription plans (i.e., as opposed to patients covered by Medicaid or patients with no prescription coverage). Overall, patient ou...
Heyes, D. M.; Smith, E. R.; Dini, D.; Zaki, T. A.
2011-07-01
It is shown analytically that the method of planes (MOP) [Todd, Evans, and Daivis, Phys. Rev. E 52, 1627 (1995)] and volume averaging (VA) [Cormier, Rickman, and Delph, J. Appl. Phys. 89, 99 (2001), 10.1063/1.1328406] formulas for the local pressure tensor, Pα, y(y), where α ≡ x, y, or z, are mathematically identical. In the case of VA, the sampling volume is taken to be an infinitely thin parallelepiped, with an infinite lateral extent. This limit is shown to yield the MOP expression. The treatment is extended to include the condition of mechanical equilibrium resulting from an imposed force field. This analytical development is followed by numerical simulations. The equivalence of these two methods is demonstrated in the context of non-equilibrium molecular dynamics (NEMD) simulations of boundary-driven shear flow. A wall of tethered atoms is constrained to impose a normal load and a velocity profile on the entrained central layer. The VA formula can be used to compute all components of Pαβ(y), which offers an advantage in calculating, for example, Pxx(y) for nano-scale pressure-driven flows in the x-direction, where deviations from the classical Poiseuille flow solution can occur.
Fatigue strength of Al7075 notched plates based on the local SED averaged over a control volume
Berto, Filippo; Lazzarin, Paolo
2014-01-01
When pointed V-notches weaken structural components, local stresses are singular and their intensities are expressed in terms of the notch stress intensity factors (NSIFs). These parameters have been widely used for fatigue assessments of welded structures under high cycle fatigue and sharp notches in plates made of brittle materials subjected to static loading. Fine meshes are required to capture the asymptotic stress distributions ahead of the notch tip and evaluate the relevant NSIFs. On the other hand, when the aim is to determine the local Strain Energy Density (SED) averaged in a control volume embracing the point of stress singularity, refined meshes are, not at all, necessary. The SED can be evaluated from nodal displacements and regular coarse meshes provide accurate values for the averaged local SED. In the present contribution, the link between the SED and the NSIFs is discussed by considering some typical welded joints and sharp V-notches. The procedure based on the SED has been also proofed to be useful for determining theoretical stress concentration factors of blunt notches and holes. In the second part of this work an application of the strain energy density to the fatigue assessment of Al7075 notched plates is presented. The experimental data are taken from the recent literature and refer to notched specimens subjected to different shot peening treatments aimed to increase the notch fatigue strength with respect to the parent material.
Chaynikov, S.; Porta, G.; Riva, M.; Guadagnini, A.
2012-04-01
We focus on a theoretical analysis of nonreactive solute transport in porous media through the volume averaging technique. Darcy-scale transport models based on continuum formulations typically include large scale dispersive processes which are embedded in a pore-scale advection diffusion equation through a Fickian analogy. This formulation has been extensively questioned in the literature due to its inability to depict observed solute breakthrough curves in diverse settings, ranging from the laboratory to the field scales. The heterogeneity of the pore-scale velocity field is one of the key sources of uncertainties giving rise to anomalous (non-Fickian) dispersion in macro-scale porous systems. Some of the models which are employed to interpret observed non-Fickian solute behavior make use of a continuum formulation of the porous system which assumes a two-region description and includes a bimodal velocity distribution. A first class of these models comprises the so-called ''mobile-immobile'' conceptualization, where convective and dispersive transport mechanisms are considered to dominate within a high velocity region (mobile zone), while convective effects are neglected in a low velocity region (immobile zone). The mass exchange between these two regions is assumed to be controlled by a diffusive process and is macroscopically described by a first-order kinetic. An extension of these ideas is the two equation ''mobile-mobile'' model, where both transport mechanisms are taken into account in each region and a first-order mass exchange between regions is employed. Here, we provide an analytical derivation of two region "mobile-mobile" meso-scale models through a rigorous upscaling of the pore-scale advection diffusion equation. Among the available upscaling methodologies, we employ the Volume Averaging technique. In this approach, the heterogeneous porous medium is supposed to be pseudo-periodic, and can be represented through a (spatially) periodic unit cell
Li, Ri; Zhou, Liming; Wang, Jian; Li, Yan
2017-02-01
Based on solidification theory and a volume-averaged multiphase solidification model, the solidification process of NH4Cl-70 pct H2O was numerically simulated and experimentally verified. Although researchers have investigated the solidification process of NH4Cl-70 pct H2O, most existing studies have been focused on analysis of a single phenomenon, such as the formation of channel segregation, convection types, and the formation of grains. Based on prior studies, by combining numerical simulation and experimental investigation, all phenomena of the entire computational domain of the solidification process of an NH4Cl aqueous solution were comprehensively investigated for the first time in this study. In particular, the sedimentation of equiaxed grains in the ingot and the induced convection were reproduced. In addition, the formation mechanism of segregation was studied in depth. The calculation demonstrated that the equiaxed grains settled from the wall of the mold and gradually aggregated at the bottom of the mold; when the volume fraction reached a critical value, the columnar grains stopped growing, thus completing the columnar-to-equiaxed transition (CET). Because of solute partitioning, negative segregation occurred at the bottom region of the ingot concentrated with grains, whereas a wide range of positive segregation occurred in the unsolidified, upper part of the ingot. Experimental investigation indicated that the predicted results of the sedimentation of the equiaxed grains in the ingot and the convection types agreed well with the experimental results, thus revealing that the sedimentation of solid phase and convection in the solidification process are the key factors responsible for macrosegregation.
Yao, Dezhong
2017-02-14
Currently, average reference is one of the most widely adopted references in EEG and ERP studies. The theoretical assumption is the surface potential integral of a volume conductor being zero, thus the average of scalp potential recordings might be an approximation of the theoretically desired zero reference. However, such a zero integral assumption has been proved only for a spherical surface. In this short communication, three counter-examples are given to show that the potential integral over the surface of a dipole in a volume conductor may not be zero. It depends on the shape of the conductor and the orientation of the dipole. This fact on one side means that average reference is not a theoretical 'gold standard' reference, and on the other side reminds us that the practical accuracy of average reference is not only determined by the well-known electrode array density and its coverage but also intrinsically by the head shape. It means that reference selection still is a fundamental problem to be fixed in various EEG and ERP studies.
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Okuda Miyuki
2012-09-01
Full Text Available Abstract Introduction We were able to treat a patient with acute exacerbation of chronic obstructive pulmonary disease who also suffered from sleep-disordered breathing by using the average volume-assured pressure support mode of a Respironics V60 Ventilator (Philips Respironics: United States. This allows a target tidal volume to be set based on automatic changes in inspiratory positive airway pressure. This removed the need to change the noninvasive positive pressure ventilation settings during the day and during sleep. The Respironics V60 Ventilator, in the average volume-assured pressure support mode, was attached to our patient and improved and stabilized his sleep-related hypoventilation by automatically adjusting force to within an acceptable range. Case presentation Our patient was a 74-year-old Japanese man who was hospitalized for treatment due to worsening of dyspnea and hypoxemia. He was diagnosed with acute exacerbation of chronic obstructive pulmonary disease and full-time biphasic positive airway pressure support ventilation was initiated. Our patient was temporarily provided with portable noninvasive positive pressure ventilation at night-time following an improvement in his condition, but his chronic obstructive pulmonary disease again worsened due to the recurrence of a respiratory infection. During the initial exacerbation, his tidal volume was significantly lower during sleep (378.9 ± 72.9mL than while awake (446.5 ± 63.3mL. A ventilator that allows ventilation to be maintained by automatically adjusting the inspiratory force to within an acceptable range was attached in average volume-assured pressure support mode, improving his sleep-related hypoventilation, which is often associated with the use of the Respironics V60 Ventilator. Polysomnography performed while our patient was on noninvasive positive pressure ventilation revealed obstructive sleep apnea syndrome (apnea-hypopnea index = 14, suggesting that his chronic
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Fugal, M; McDonald, D; Jacqmin, D; Koch, N; Ellis, A; Peng, J; Ashenafi, M; Vanek, K [Medical University of South Carolina, Charleston, SC (United States)
2015-06-15
Purpose: This study explores novel methods to address two significant challenges affecting measurement of patient-specific quality assurance (QA) with IBA’s Matrixx Evolution™ ionization chamber array. First, dose calculation algorithms often struggle to accurately determine dose to the chamber array due to CT artifact and algorithm limitations. Second, finite chamber size and volume averaging effects cause additional deviation from the calculated dose. Methods: QA measurements were taken with the Matrixx positioned on the treatment table in a solid-water Multi-Cube™ phantom. To reduce the effect of CT artifact, the Matrixx CT image set was masked with appropriate materials and densities. Individual ionization chambers were masked as air, while the high-z electronic backplane and remaining solid-water material were masked as aluminum and water, respectively. Dose calculation was done using Varian’s Acuros XB™ (V11) algorithm, which is capable of predicting dose more accurately in non-biologic materials due to its consideration of each material’s atomic properties. Finally, the exported TPS dose was processed using an in-house algorithm (MATLAB) to assign the volume averaged TPS dose to each element of a corresponding 2-D matrix. This matrix was used for comparison with the measured dose. Square fields at regularly-spaced gantry angles, as well as selected patient plans were analyzed. Results: Analyzed plans showed improved agreement, with the average gamma passing rate increasing from 94 to 98%. Correction factors necessary for chamber angular dependence were reduced by 67% compared to factors measured previously, indicating that previously measured factors corrected for dose calculation errors in addition to true chamber angular dependence. Conclusion: By comparing volume averaged dose, calculated with a capable dose engine, on a phantom masked with correct materials and densities, QA results obtained with the Matrixx Evolution™ can be significantly
Vassiliou, Vassilios S; Wassilew, Katharina; Cameron, Donnie; Heng, Ee Ling; Nyktari, Evangelia; Asimakopoulos, George; de Souza, Anthony; Giri, Shivraman; Pierce, Iain; Jabbour, Andrew; Firmin, David; Frenneaux, Michael; Gatehouse, Peter; Pennell, Dudley J; Prasad, Sanjay K
2017-06-12
Our objectives involved identifying whether repeated averaging in basal and mid left ventricular myocardial levels improves precision and correlation with collagen volume fraction for 11 heartbeat MOLLI T 1 mapping versus assessment at a single ventricular level. For assessment of T 1 mapping precision, a cohort of 15 healthy volunteers underwent two CMR scans on separate days using an 11 heartbeat MOLLI with a 5(3)3 beat scheme to measure native T 1 and a 4(1)3(1)2 beat post-contrast scheme to measure post-contrast T 1, allowing calculation of partition coefficient and ECV. To assess correlation of T 1 mapping with collagen volume fraction, a separate cohort of ten aortic stenosis patients scheduled to undergo surgery underwent one CMR scan with this 11 heartbeat MOLLI scheme, followed by intraoperative tru-cut myocardial biopsy. Six models of myocardial diffuse fibrosis assessment were established with incremental inclusion of imaging by averaging of the basal and mid-myocardial left ventricular levels, and each model was assessed for precision and correlation with collagen volume fraction. A model using 11 heart beat MOLLI imaging of two basal and two mid ventricular level averaged T 1 maps provided improved precision (Intraclass correlation 0.93 vs 0.84) and correlation with histology (R (2) = 0.83 vs 0.36) for diffuse fibrosis compared to a single mid-ventricular level alone. ECV was more precise and correlated better than native T 1 mapping. T 1 mapping sequences with repeated averaging could be considered for applications of 11 heartbeat MOLLI, especially when small changes in native T 1/ECV might affect clinical management.
Microfluidic Cell Volume Biosensor for High Throughput Drug Screening
2005-01-01
method is non- invasive, and it provides real-time measurement of changes in cell volume for both adherent and suspended cells. The microfluidic nature of...channels as well as the release of organic osmolytes, such as taurine [11]. Upon returning to isotonic solution at the end of RVD we observed cell...Haussinger, Biochem. J, 313,697 (1996). [2] Sachs, F. Nature Structural Biology 9, 636-637 (2002). [3] F. Schliess, and D. Haussinger, Bio. Chem. 383
Haufe, Stefan; Huang, Yu; Parra, Lucas C
2015-08-01
In electroencephalographic (EEG) source imaging as well as in transcranial current stimulation (TCS), it is common to model the head using either three-shell boundary element (BEM) or more accurate finite element (FEM) volume conductor models. Since building FEMs is computationally demanding and labor intensive, they are often extensively reused as templates even for subjects with mismatching anatomies. BEMs can in principle be used to efficiently build individual volume conductor models; however, the limiting factor for such individualization are the high acquisition costs of structural magnetic resonance images. Here, we build a highly detailed (0.5mm(3) resolution, 6 tissue type segmentation, 231 electrodes) FEM based on the ICBM152 template, a nonlinear average of 152 adult human heads, which we call ICBM-NY. We show that, through more realistic electrical modeling, our model is similarly accurate as individual BEMs. Moreover, through using an unbiased population average, our model is also more accurate than FEMs built from mismatching individual anatomies. Our model is made available in Matlab format.
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Faralli, Adele; Melander, Fredrik; Larsen, Esben Kjær Unmack;
2014-01-01
Polyethylene glycol (PEG)-based hydrogels are widely used for biomedical applications, including matrices for controlled drug release. We present a method for defining drug dosing in screening assays by light-activated cross-linking of PEG-diacrylate hydrogels with embedded drug-loaded liposome...
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Yao-Ching Wang
Full Text Available Respiratory motion causes uncertainties in tumor edges on either computed tomography (CT or positron emission tomography (PET images and causes misalignment when registering PET and CT images. This phenomenon may cause radiation oncologists to delineate tumor volume inaccurately in radiotherapy treatment planning. The purpose of this study was to analyze radiology applications using interpolated average CT (IACT as attenuation correction (AC to diminish the occurrence of this scenario. Thirteen non-small cell lung cancer patients were recruited for the present comparison study. Each patient had full-inspiration, full-expiration CT images and free breathing PET images by an integrated PET/CT scan. IACT for AC in PET(IACT was used to reduce the PET/CT misalignment. The standardized uptake value (SUV correction with a low radiation dose was applied, and its tumor volume delineation was compared to those from HCT/PET(HCT. The misalignment between the PET(IACT and IACT was reduced when compared to the difference between PET(HCT and HCT. The range of tumor motion was from 4 to 17 mm in the patient cohort. For HCT and PET(HCT, correction was from 72% to 91%, while for IACT and PET(IACT, correction was from 73% to 93% (*p<0.0001. The maximum and minimum differences in SUVmax were 0.18% and 27.27% for PET(HCT and PET(IACT, respectively. The largest percentage differences in the tumor volumes between HCT/PET and IACT/PET were observed in tumors located in the lowest lobe of the lung. Internal tumor volume defined by functional information using IACT/PET(IACT fusion images for lung cancer would reduce the inaccuracy of tumor delineation in radiation therapy planning.
U.S. Department of Health & Human Services — A list of a variety of averages for each state or territory as well as the national average, including each quality measure, staffing, fine amount and number of...
Tanaka, Akiko; Furubayashi, Tomoyuki; Enomura, Yuki; Hori, Tomoki; Shimomura, Rina; Maeda, Chiaki; Kimura, Shunsuke; Inoue, Daisuke; Kusamori, Kosuke; Katsumi, Hidemasa; Sakane, Toshiyasu; Yamamoto, Akira
2017-01-01
The effect of changes in the mucosal fluid volume on the nasal drug absorption of powder formulations was evaluated using warfarin (WF), piroxicam (PXC), and norfloxacin (NFX) as model drugs. Lactose and sodium chloride (NaCl), which are water soluble and small-sized chemicals that increase osmotic pressure after dissolution, were used as excipients to change the mucosal fluid volume. The in vitro study using a Madin-Darby canine kidney (MDCK) cell monolayer indicated that lactose and NaCl, sprayed over the surface of air interface monolayers, increased the fluid volume on the monolayer surface and enhanced the transepithelial transport of the model drugs. The in vivo animal study indicated that the nasal absorption of PXC is enhanced by lactose and NaCl after nasal administration of the powder formulations. This is likely due to the enhanced dissolution of PXC on fluid-rich nasal mucosa and an increase in the effective surface area for drug permeation, which lead to better nasal absorption. However, both excipients failed to increase the nasal absorption of WF and NFX. To clarify the mechanism of the drug-dependent effect of lactose and NaCl, the nasal residence of the formulation was examined using FD70 as a non-absorbable marker. The nasal clearance of FD70 was enhanced by lactose and NaCl, leading to a decrease in the nasal drug absorption. Lactose and NaCl caused no damage to the nasal tissue. These results indicate that the addition of water-soluble excipients such as lactose to powder formulations can enhance the nasal absorption of highly permeable but poorly soluble drugs.
Sevcik, Carlos; Salazar, Victor; Díaz, Patricia; D'Suze, Gina
2007-10-01
Fast disappearance of F(ab')2 antivenoms from the plasma compartment [Sevcik et al., 2004. Modelling Tityus scorpion venom and antivenom pharmacokinetics. Evidence of active immunoglobulin G's F(ab')2 extrusion mechanism from blood to tissues. Toxicon 44, 731-734; Vazquez et al., 2005. Pharmacokinetics of a F(ab')2 scorpion antivenom in healthy human volunteers. Toxicon 46, 797-805] suggests a quick time course to reach its final distribution volume. An equation was developed to describe how the volume occupied by a drug in the body grows with time. As discussed in the paper this equation is free of some shortcomings of an equation developed for the same purpose by Niazi [1976. Volume of distribution as a function of time. J. Pharm. Sci. 65, 452-454]. Fluorescence microscopy showed that the rapid initial decay in plasmatic F(ab')2 concentration may be related to uptake of F(ab')2 by vascular endothelium which, in combination with accumulation in the vascular wall connective tissue, may produce an intermediate plateau in F(ab')2 V(sl)(t), which reached its final value after 10 h. The V(sl)(t) equation predicts that the plasma concentration half-time of decay has little use to estimate how a drug distributes through the body to exert its action, and predicts that, in some instances, intermediate plateaus in the time course of V(sl)(t) exist. Data from the literature showed that the kinetic considerations for V(sl)(t) also apply to clevidipine, digoxin, digitoxin, lidocaine and thiopentone.
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Fang Tang
2016-01-01
Full Text Available The aim of this study was to apply the reference-scaled average bioequivalence (RSABE approach to evaluate the bioequivalence of 2 formulations of agomelatine, and to investigate the pharmacokinetic properties of agomelatine in Chinese healthy male subjects. This was performed in a single-dose, randomized-sequence, open-label, four-way crossover study with a one-day washout period between doses. Healthy Chinese males were randomly assigned to receive 25 mg of either the test or reference formulation. The formulations were considered bioequivalent if 90% confidence intervals (CIs for the log-transformed ratios and ratio of geometric means (GMR of AUC and Cmax of agomelatine were within the predetermined bioequivalence range based on RSABE method. Results showed that both of the 90% CIs for the log-transformed ratios of AUC and Cmax of 7-desmethyl-agomelatine and 3-hydroxy-agomelatine were within the predetermined bioequivalence range. The 90% CIs for natural log-transformed ratios of Cmax, AUC0–t and AUC0–∞ of agomelatine (104.42–139.86, 101.33–123.83 and 97.90–117.94 were within the RSABE acceptance limits, and 3-hydroxy-agomelatine (105.55–123.03, 101.95–109.10 and 101.72–108.70 and 7-desmethyl-agomelatine (104.50–125.23, 102.36–111.50 and 101.62–110.64 were within the FDA bioequivalence definition intervals (0.80–1.25 for AUC and 0.75–1.33 for Cmax. The RSABE approach was successful in evaluating the bioequivalence of these two formulations.
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Alexoff, David L., E-mail: alexoff@bnl.gov; Dewey, Stephen L.; Vaska, Paul; Krishnamoorthy, Srilalan; Ferrieri, Richard; Schueller, Michael; Schlyer, David J.; Fowler, Joanna S.
2011-02-15
Introduction: PET imaging in plants is receiving increased interest as a new strategy to measure plant responses to environmental stimuli and as a tool for phenotyping genetically engineered plants. PET imaging in plants, however, poses new challenges. In particular, the leaves of most plants are so thin that a large fraction of positrons emitted from PET isotopes ({sup 18}F, {sup 11}C, {sup 13}N) escape while even state-of-the-art PET cameras have significant partial-volume errors for such thin objects. Although these limitations are acknowledged by researchers, little data have been published on them. Methods: Here we measured the magnitude and distribution of escaping positrons from the leaf of Nicotiana tabacum for the radionuclides {sup 18}F, {sup 11}C and {sup 13}N using a commercial small-animal PET scanner. Imaging results were compared to radionuclide concentrations measured from dissection and counting and to a Monte Carlo simulation using GATE (Geant4 Application for Tomographic Emission). Results: Simulated and experimentally determined escape fractions were consistent. The fractions of positrons (mean{+-}S.D.) escaping the leaf parenchyma were measured to be 59{+-}1.1%, 64{+-}4.4% and 67{+-}1.9% for {sup 18}F, {sup 11}C and {sup 13}N, respectively. Escape fractions were lower in thicker leaf areas like the midrib. Partial-volume averaging underestimated activity concentrations in the leaf blade by a factor of 10 to 15. Conclusions: The foregoing effects combine to yield PET images whose contrast does not reflect the actual activity concentrations. These errors can be largely corrected by integrating activity along the PET axis perpendicular to the leaf surface, including detection of escaped positrons, and calculating concentration using a measured leaf thickness.
Energy Technology Data Exchange (ETDEWEB)
Alexoff, D.L.; Alexoff, D.L.; Dewey, S.L.; Vaska, P.; Krishnamoorthy, S.; Ferrieri, R.; Schueller, M.; Schlyer, D.; Fowler, J.S.
2011-03-01
PET imaging in plants is receiving increased interest as a new strategy to measure plant responses to environmental stimuli and as a tool for phenotyping genetically engineered plants. PET imaging in plants, however, poses new challenges. In particular, the leaves of most plants are so thin that a large fraction of positrons emitted from PET isotopes ({sup 18}F, {sup 11}C, {sup 13}N) escape while even state-of-the-art PET cameras have significant partial-volume errors for such thin objects. Although these limitations are acknowledged by researchers, little data have been published on them. Here we measured the magnitude and distribution of escaping positrons from the leaf of Nicotiana tabacum for the radionuclides {sup 18}F, {sup 11}C and {sup 13}N using a commercial small-animal PET scanner. Imaging results were compared to radionuclide concentrations measured from dissection and counting and to a Monte Carlo simulation using GATE (Geant4 Application for Tomographic Emission). Simulated and experimentally determined escape fractions were consistent. The fractions of positrons (mean {+-} S.D.) escaping the leaf parenchyma were measured to be 59 {+-} 1.1%, 64 {+-} 4.4% and 67 {+-} 1.9% for {sup 18}F, {sup 11}C and {sup 13}N, respectively. Escape fractions were lower in thicker leaf areas like the midrib. Partial-volume averaging underestimated activity concentrations in the leaf blade by a factor of 10 to 15. The foregoing effects combine to yield PET images whose contrast does not reflect the actual activity concentrations. These errors can be largely corrected by integrating activity along the PET axis perpendicular to the leaf surface, including detection of escaped positrons, and calculating concentration using a measured leaf thickness.
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Barraclough, B; Lebron, S [J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL (United States); Li, J; Fan, Qiyong; Liu, C; Yan, G [Department of Radiation Oncology, University of Florida, Gainesville, FL (United States)
2015-06-15
Purpose: A novel convolution-based approach has been proposed to address ion chamber (IC) volume averaging effect (VAE) for the commissioning of commercial treatment planning systems (TPS). We investigate the use of various convolution kernels and its impact on the accuracy of beam models. Methods: Our approach simulates the VAE by iteratively convolving the calculated beam profiles with a detector response function (DRF) while optimizing the beam model. At convergence, the convolved profiles match the measured profiles, indicating the calculated profiles match the “true” beam profiles. To validate the approach, beam profiles of an Elekta LINAC were repeatedly collected with ICs of various volumes (CC04, CC13 and SNC 125) to obtain clinically acceptable beam models. The TPS-calculated profiles were convolved externally with the DRF of respective IC. The beam model parameters were reoptimized using Nelder-Mead method by forcing the convolved profiles to match the measured profiles. We evaluated three types of DRFs (Gaussian, Lorentzian, and parabolic) and the impact of kernel dependence on field geometry (depth and field size). The profiles calculated with beam models were compared with SNC EDGE diode-measured profiles. Results: The method was successfully implemented with Pinnacle Scripting and Matlab. The reoptimization converged in ∼10 minutes. For all tested ICs and DRFs, penumbra widths of the TPS-calculated profiles and diode-measured profiles were within 1.0 mm. Gaussian function had the best performance with mean penumbra width difference within 0.5 mm. The use of geometry dependent DRFs showed marginal improvement, reducing the penumbra width differences to less than 0.3 mm. Significant increase in IMRT QA passing rates was achieved with the optimized beam model. Conclusion: The proposed approach significantly improved the accuracy of the TPS beam model. Gaussian functions as the convolution kernel performed consistently better than Lorentzian and
Comparing Generic Drug Markets in Europe and the United States: Prices, Volumes, and Spending.
Wouters, Olivier J; Kanavos, Panos G; McKEE, Martin
2017-09-01
Policy Points: Our study indicates that there are opportunities for cost savings in generic drug markets in Europe and the United States. Regulators should make it easier for generic drugs to reach the market. Regulators and payers should apply measures to stimulate price competition among generic drugmakers and to increase generic drug use. To meaningfully evaluate policy options, it is important to analyze historical context and understand why similar initiatives failed previously. Rising drug prices are putting pressure on health care budgets. Policymakers are assessing how they can save money through generic drugs. We compared generic drug prices and market shares in 13 European countries, using data from 2013, to assess the amount of variation that exists between countries. To place these results in context, we reviewed evidence from recent studies on the prices and use of generics in Europe and the United States. We also surveyed peer-reviewed studies, gray literature, and books published since 2000 to (1) outline existing generic drug policies in European countries and the United States; (2) identify ways to increase generic drug use and to promote price competition among generic drug companies; and (3) explore barriers to implementing reform of generic drug policies, using a historical example from the United States as a case study. The prices and market shares of generics vary widely across Europe. For example, prices charged by manufacturers in Switzerland are, on average, more than 2.5 times those in Germany and more than 6 times those in the United Kingdom, based on the results of a commonly used price index. The proportion of prescriptions filled with generics ranges from 17% in Switzerland to 83% in the United Kingdom. By comparison, the United States has historically had low generic drug prices and high rates of generic drug use (84% in 2013), but has in recent years experienced sharp price increases for some off-patent products. There are policy
Keshvari, Jafar; Heikkilä, Teemu
2011-12-01
Previous studies comparing SAR difference in the head of children and adults used highly simplified generic models or half-wave dipole antennas. The objective of this study was to investigate the SAR difference in the head of children and adults using realistic EMF sources based on CAD models of commercial mobile phones. Four MRI-based head phantoms were used in the study. CAD models of Nokia 8310 and 6630 mobile phones were used as exposure sources. Commercially available FDTD software was used for the SAR calculations. SAR values were simulated at frequencies 900 MHz and 1747 MHz for Nokia 8310, and 900 MHz, 1747 MHz and 1950 MHz for Nokia 6630. The main finding of this study was that the SAR distribution/variation in the head models highly depends on the structure of the antenna and phone model, which suggests that the type of the exposure source is the main parameter in EMF exposure studies to be focused on. Although the previous findings regarding significant role of the anatomy of the head, phone position, frequency, local tissue inhomogeneity and tissue composition specifically in the exposed area on SAR difference were confirmed, the SAR values and SAR distributions caused by generic source models cannot be extrapolated to the real device exposures. The general conclusion is that from a volume averaged SAR point of view, no systematic differences between child and adult heads were found.
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I. Morino
2010-12-01
Full Text Available Column-averaged volume mixing ratios of carbon dioxide and methane retrieved from the Greenhouse gases Observing SATellite (GOSAT Short-Wavelength InfraRed observation (GOSAT SWIR X_{CO2} and X_{CH4} were compared with the reference data obtained by ground-based high-resolution Fourier Transform Spectrometers (g-b FTSs participating in the Total Carbon Column Observing Network (TCCON.
Through calibrations of g-b FTSs with airborne in-situ measurements, the uncertainty of X_{CO2} and X_{CH4} associated with the g-b FTS was determined to be 0.8 ppm (~0.2% and 4 ppb (~0.2%, respectively. The GOSAT products are validated with these calibrated g-b FTS data. Preliminary results are as follows: The GOSAT SWIR X_{CO2} and X_{CH4} (Version 01.xx are biased low by 8.85 ± 4.75 ppm (2.3 ± 1.2% and 20.4 ± 18.9 ppb (1.2 ± 1.1%, respectively. The precision of the GOSAT SWIR X_{CO2} and X_{CH4} is considered to be about 1%. The latitudinal distributions of zonal means of the GOSAT SWIR X_{CO2} and X_{CH4} show similar features to those of the g-b FTS data.
Regulatory volume decrease in Leishmania mexicana: effect of anti-microtubule drugs
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Francehuli Dagger
2013-02-01
Full Text Available The trypanosomatid cytoskeleton is responsible for the parasite's shape and it is modulated throughout the different stages of the parasite's life cycle. When parasites are exposed to media with reduced osmolarity, they initially swell, but subsequently undergo compensatory shrinking referred to as regulatory volume decrease (RVD. We studied the effects of anti-microtubule (Mt drugs on the proliferation of Leishmania mexicana promastigotes and their capacity to undergo RVD. All of the drugs tested exerted antiproliferative effects of varying magnitudes [ansamitocin P3 (AP3> trifluoperazine > taxol > rhizoxin > chlorpromazine]. No direct relationship was found between antiproliferative drug treatment and RVD. Similarly, Mt stability was not affected by drug treatment. Ansamitocin P3, which is effective at nanomolar concentrations, blocked amastigote-promastigote differentiation and was the only drug that impeded RVD, as measured by light dispersion. AP3 induced 2 kinetoplasts (Kt 1 nucleus cells that had numerous flagella-associated Kts throughout the cell. These results suggest that the dramatic morphological changes induced by AP3 alter the spatial organisation and directionality of the Mts that are necessary for the parasite's hypotonic stress-induced shape change, as well as its recovery.
DEFF Research Database (Denmark)
Hoffmann, Else Kay; Sørensen, Belinda Halling; Sauter, Daniel Rafael Peter
2015-01-01
to be an essential component of both VRAC and VSOAC. Reduced VRAC and VSOAC activities are seen in drug resistant cancer cells. ANO1 is a calcium-activated chloride channel expressed on the plasma membrane of e.g. secretory epithelia. ANO1 is amplified and highly expressed in a large number of carcinomas. The gene...... functions as well as their role in cancer and drug resistance....
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Chuan-Jun Zhuo
2016-01-01
Conclusions: Although the results of the present study suggest the absence of significant differences in brain gray matter volume between female drug-naive patients after the first episode of major depression with and without SLEs after FDR correction, the study provides useful information for exploring the definitive role of stress in the onset of depression.
Gongadze, Ekaterina; Iglič, Aleš
2013-03-01
Water ordering near a negatively charged electrode is one of the decisive factors determining the interactions of an electrode with the surrounding electrolyte solution or tissue. In this work, the generalized Langevin-Bikerman model (Gongadze-Iglič model) taking into account the cavity field and the excluded volume principle is used to calculate the space dependency of ions and water number densities in the vicinity of a highly charged surface. It is shown that for high enough surface charged densities the usual trend of increasing counterion number density towards the charged surface may be completely reversed, i.e. the drop in the counterions number density near the charged surface is predicted.
DEFF Research Database (Denmark)
Glenthoj, Andreas; Glenthøj, Birte Yding; Mackeprang, Torben
2007-01-01
and 19 matched controls participated. Patients were randomly assigned to treatment with either low doses of the typical antipsychotic drug, zuclopenthixol, or the atypical compound, risperidone. High-resolution magnetic resonance imaging (MRI) scans were obtained in patients before and after 12 weeks...... medication groups did not differ significantly with respect to volume changes after 3 months of low dose treatment in any of the VOIs. Nevertheless, when medication groups were examined separately, a significant volume increase in the putamen was evidenced in the risperidone group. The altered asymmetry...
Bioavailability of vitamin B using a small-volume nebulizer ophthalmic drug delivery system.
Kahn, Monte
2005-08-01
To determine the intraocular bioavailability of a novel embodiment for vitamin B(12) delivered to the ocular surface by a piezo-electric ultrasonic nebulizer. The semisolid embodiment contained 0.02% (w/w) vitamin B(12) in 1 g of ointment, which was immiscible and insoluble in 5 mL sterilized warm water. To confirm in vitro functionality, nebulized mist particles of the embodiment were collected and analysed for vitamin B(12) content. The in vivo arm of the study was designed as randomization of 23 patients who were scheduled to undergo cataract surgery in hospital. Fourteen patients were treated with nebulized vitamin B(12), five patients had one drop of 0.02% vitamin B(12) instilled in the conjunctival cul de sac, and four control patients had no medication. Twelve hours after the vitamin was delivered, the patients underwent the cataract procedure and a sample of aqueous humour was collected from each. High performance liquid chromatography was used for detection of vitamin B(12) in all samples. The in vitro analysis of mist particles showed increasing concentrations of vitamin B(12). In the patient tests, analysis of the aqueous humour samples showed that none of the controls or those receiving eye drops had detectable vitamin B(12) in the aqueous humour. However, 4 of 14 in the nebulizer group had vitamin B(12) detected in the aqueous humour in the amount of 10(-7) mol. The small-volume nebulizer system might provide another method of ophthalmic drug delivery.
1978
The papers in this volume were prepared as part of an evaluation of the effects of the strict 1973 New York State drug laws. The first paper explores the effects of the laws on heroin use. It analyzes the trends of various indicators of heroin use in New York State over a period of several years. In order to isolate movements unique to New York,…
Institute of Scientific and Technical Information of China (English)
Chuan-Jun Zhuo; Hai-Man Bian; Yan-Jie Gao; Xiao-Lei Ma; Sheng-Zhang Ji; Meng-Yuan Yao; Ning Zhai
2016-01-01
Background: This study aimed to observe the differences in brain gray matter volume in drug-naive female patients after the first episode of major depression with and without stressful life events (SLEs) before the onset of depression.Methods: Forty-three drug-naive female patients voluntarily participated in the present study after the first major depressive episode.The life event scale was used to evaluate the severity of the impact of SLEs during 6 months before the onset of the major depressive episode.High-field magnetic resonance imaging (MRI) scans were obtained, and the VBM and SPM8 software process were used to process and analyze the MRI.Results: Compared to that in patients without SLEs, the volume of brain gray matter was lower in the bilateral temporal lobe, right occipital lobe, and right limbic lobe in the SLE group.However, the gray matter volume did not differ significantly between the two groups after the application of false discovery rate (FDR) correction.Conclusions: Although the results of the present study suggest the absence of significant differences in brain gray matter volume between female drug-naive patients after the first episode of major depression with and without SLEs after FDR correction, the study provides useful information for exploring the definitive role of stress in the onset of depression.
Mathieu, Véronique; Chantôme, Aurélie; Lefranc, Florence; Cimmino, Alessio; Miklos, Walter; Paulitschke, Verena; Mohr, Thomas; Maddau, Lucia; Kornienko, Alexander; Berger, Walter; Vandier, Christophe; Evidente, Antonio; Delpire, Eric; Kiss, Robert
2016-01-01
Despite the recent advances in the treatment of tumors with intrinsic chemotherapy resistance, such as melanoma and renal cancers, their prognosis remains poor and new chemical agents with promising activity against these cancers are urgently needed. Sphaeropsidin A, a fungal metabolite whose anticancer potential had previously received little attention, was isolated from Diplodia cupressi and found to display specific anticancer activity in vitro against melanoma and kidney cancer subpanels in the National Cancer Institute (NCI) 60-cell line screen. The NCI data revealed a mean LC50 of ca. 10 μM and a cellular sensitivity profile that did not match that of any other agent in the 765,000 compound database. Subsequent mechanistic studies in melanoma and other multidrug-resistant in vitro cancer models showed that sphaeropsidin A can overcome apoptosis as well as multidrug resistance by inducing a marked and rapid cellular shrinkage related to the loss of intracellular Cl− and the decreased HCO3− concentration in the culture supernatant. These changes in ion homeostasis and the absence of effects on the plasma membrane potential were attributed to the sphaeropsidin A-induced impairment of regulatory volume increase (RVI). Preliminary results also indicate that depending on the type of cancer, the sphaeropsidin A effects on RVI could be related to Na–K–2Cl electroneutral cotransporter or Cl−/HCO3− anion exchanger(s) targeting. This study underscores the modulation of ion-transporter activity as a promising therapeutic strategy to combat drug-resistant cancers and identifies the fungal metabolite, sphaeropsidin A, as a lead to develop anticancer agents targeting RVI in cancer cells. PMID:25868554
A Handbook for Alcohol and Drug Control Officers. Volume II. Appendices.
1975-02-01
or from alchohol to drugs.) What if they are caught using drugs or under the influence of alcohol? (Probe for action both at the unit level and at...you try any new drugs on this post? What led to these changes or new drugs? Has your alchohol consumption changed on this post? What led to the...no specific relationship to any other characteristic. Systematic random sampling, an alternative to simple random sampling, is a mechanism whereby
Caltrans Average Annual Daily Traffic Volumes (2004)
California Environmental Health Tracking Program — [ from http://www.ehib.org/cma/topic.jsp?topic_key=79 ] Traffic exhaust pollutants include compounds such as carbon monoxide, nitrogen oxides, particulates (fine...
Alcohol, other Drugs, and Obesity: Plan-Of-The-Day-Notes, Volume 2
1993-08-11
delusions, and paranoia suffered by the abusers. Many users of LSD voluntarily decrease or stop its use over time. LSD is not considered to be an addicting ...of the addicting drugs, LSD produces tolerance, so that some users who take the drug repeatedly, progressively take higher and higher doses in order to...33 Inhalants ............ .................. .. 35 Ice ................ ..................... .. 37 LSD
Energy Technology Data Exchange (ETDEWEB)
Monroy Anton, J. L.; Solar Tortosa, M.; Lopez Munoz, M.; Navarro Bergada, A.; Estornell Gualde, M. A.; Melchor Iniguez, M.
2013-07-01
Our objective was to evaluate the V20 parameters and dose average compared to a single lung volume designed with a CT study in normal breathing of the patient and the corresponding to a lung volume composed, designed from three studies of CT in different phases of the respiratory cycle. Check if there are important differences in these cases that determine the necessity of creating a composite lung volume to evaluate dose volume histogram. (Author)
Lombardo, Franco; Obach, R Scott; Dicapua, Frank M; Bakken, Gregory A; Lu, Jing; Potter, David M; Gao, Feng; Miller, Michael D; Zhang, Yao
2006-04-06
A computational approach is described that can predict the VD(ss) of new compounds in humans, with an accuracy of within 2-fold of the actual value. A dataset of VD values for 384 drugs in humans was used to train a hybrid mixture discriminant analysis-random forest (MDA-RF) model using 31 computed descriptors. Descriptors included terms describing lipophilicity, ionization, molecular volume, and various molecular fragments. For a test set of 23 proprietary compounds not used in model construction, the geometric mean fold-error (GMFE) was 1.78-fold (+/-11.4%). The model was also tested using a leave-class out approach wherein subsets of drugs based on therapeutic class were removed from the training set of 384, the model was recast, and the VD(ss) values for each of the subsets were predicted. GMFE values ranged from 1.46 to 2.94-fold, depending on the subset. Finally, for an additional set of 74 compounds, VD(ss) predictions made using the computational model were compared to predictions made using previously described methods dependent on animal pharmacokinetic data. Computational VD(ss) predictions were, on average, 2.13-fold different from the VD(ss) predictions from animal data. The computational model described can predict human VD(ss) with an accuracy comparable to predictions requiring substantially greater effort and can be applied in place of animal experimentation.
Energy Technology Data Exchange (ETDEWEB)
Fazleev, M.P.; Chekhov, O.S.; Ermakov, E.A.
1985-06-20
This paper discusses the results of an investigation of the gas content averaged over the volume, hydrodynamic programs, and foaming in the K/sub 2/O-V/sub 2/O/sub 5/ melt plus gas system, which is used as a catalyst in several thermocatalytic processes. The experimental setup is described and a comparison of literature data on the gas content of different gas-liquid systems under comparable conditions is presented. The authors were able to determine the boundaries of the hydrodynamic modes in a bubbling reactor and derive equations for the calculation of the gas content. It was found that the gas content of the melt increased when V/sub 2/O/sub 5/ was reduced to V/sub 2/O/sub 4/ in the reaction portion of the reaction-regeneration cycle. Regeneration of the melt restores the value of gas content to its original level.
Changes in blood volume and response to vaso-active drugs in horizontally casted primates
Dickey, D. T.; Teoh, K. K.; Sandler, H.; Stone, H. L.
1982-01-01
Experiments were performed on horizontally casted primates (male rhesus monkeys) in order to note changes in blood volume caused by horizontal restraint, to compare orthostatic tolerance before and after casting using the responses to upright tilting, to begin to uncover the cardiovascular and neural mechanisms involved in deconditioning, and to compare the data with that obtained from bed-rested human subjects and from humans exposed to weightlessness. Bolus injections of norepinephrine of 2.0 microgram/kg, phenylephrine of 4.0 microgram/kg, and nitroprusside of 2.0 microgram/kg were administered; and aortic pressure and heart rate were recorded during the injections. The results indicate that the horizontally casted primate is a valid animal model for studying the effects of simulated zero-G on the human cardiovascular system.
Averaged Lema\\^itre-Tolman-Bondi dynamics
Isidro, Eddy G Chirinos; Piattella, Oliver F; Zimdahl, Winfried
2016-01-01
We consider cosmological backreaction effects in Buchert's averaging formalism on the basis of an explicit solution of the Lema\\^itre-Tolman-Bondi (LTB) dynamics which is linear in the LTB curvature parameter and has an inhomogeneous bang time. The volume Hubble rate is found in terms of the volume scale factor which represents a derivation of the simplest phenomenological solution of Buchert's equations in which the fractional densities corresponding to average curvature and kinematic backreaction are explicitly determined by the parameters of the underlying LTB solution at the boundary of the averaging volume. This configuration represents an exactly solvable toy model but it does not adequately describe our "real" Universe.
Low-volume binary drug therapy for the treatment of hypovolemia.
Bhattacharjee, Himanshu; Nadipuram, Asha; Kosanke, Stanley; Kiani, Mohammad F; Moore, Bob M
2011-06-01
The selective regulation of total peripheral circulation in hypovolemic crisis offers a unique approach for treating and preventing hemorrhagic shock. Ideally, such a therapeutic intervention would require targeting of the striated muscle vascular beds without altering the vascular resistance in vital organ vascular beds. We discovered that a combination of cannabinoid receptor agonist, THC (Δ-tetrahydrocannabinol), and cyclooxygenase 2 inhibitor, NS-398, caused selective microvascular constriction in the mouse cremaster muscle manifested by a pronounced and significant 27.4% ± 7.9% decrease in vessel diameter relative to control (P treatment groups (n = 6 per group). The untreated, NS-398-treated, and THC-treated groups manifested an insignificant difference in survival between groups after shock. The group treated with a combination of THC and NS-398 manifested a significant increase in mean survival from 53 ± 12 to 227 ± 23 min after shock (P shock-induced damage. The combination of cannabinoid receptor agonist and cyclooxygenase 2 inhibitor represents a potentially new approach to low-volume therapeutic intervention for hypovolemia.
Siegel, Irving H.
The arithmetic processes of aggregation and averaging are basic to quantitative investigations of employment, unemployment, and related concepts. In explaining these concepts, this report stresses need for accuracy and consistency in measurements, and describes tools for analyzing alternative measures. (BH)
DEFF Research Database (Denmark)
Gramkow, Claus
1999-01-01
In this article two common approaches to averaging rotations are compared to a more advanced approach based on a Riemannian metric. Very offten the barycenter of the quaternions or matrices that represent the rotations are used as an estimate of the mean. These methods neglect that rotations belong...... approximations to the Riemannian metric, and that the subsequent corrections are inherient in the least squares estimation. Keywords: averaging rotations, Riemannian metric, matrix, quaternion...
DEFF Research Database (Denmark)
Glenthoj, Andreas; Glenthoj, Birte Y; Mackeprang, Torben
2007-01-01
of exposure to medication and in controls at baseline. Caudate nucleus, nucleus accumbens, and putamen volumes were measured. Compared with controls, absolute volumes of interest (VOIs) were smaller in patients at baseline and increased after treatment. However, with controls for age, gender and whole brain...... medication groups did not differ significantly with respect to volume changes after 3 months of low dose treatment in any of the VOIs. Nevertheless, when medication groups were examined separately, a significant volume increase in the putamen was evidenced in the risperidone group. The altered asymmetry...
Institute of Scientific and Technical Information of China (English)
无
2003-01-01
The electrochemical behavior of ionizable drugs (Amitriptyline, Diphenhydramine and Trihexyphene- dyl) at the water/1,2-dichloroethane interface with the phase volume ratio (r = Vo/Vw) equal to 1 are investigated by cyclic voltammetry. The system is composed of an aqueous droplet supported at an Ag/AgCl disk electrode and it was covered with an organic solution. In this manner, a conventional three-electrode potentiostat can be used to study the ionizable drugs transfer process at a liquid/liquid interface. Physicochemical parameters such as the formal transfer potential, the Gibbs energy of transfer and the standard partition coefficients of the ionized forms of these drugs can be evaluated from cyclic voltammograms obtained. The obtained results have been summarized in ionic partition diagrams, which are a useful tool for predicting and interpreting the transfer mechanisms of ionizable drugs at the liquid/liquid interfaces and biological membranes.
Lifescience Database Archive (English)
Full Text Available D06539 Drug Dextran 40 (JP16/USP); Dextran D40 (TN) (C12H20O10)n D06539.gif Blood flow adjuvant; Plasma volu...me extender Same as: C00372 G10502 ATC code: B05AA05 Average molecular weight is in
Young, Vershawn Ashanti
2004-01-01
"Your Average Nigga" contends that just as exaggerating the differences between black and white language leaves some black speakers, especially those from the ghetto, at an impasse, so exaggerating and reifying the differences between the races leaves blacks in the impossible position of either having to try to be white or forever struggling to…
DEFF Research Database (Denmark)
Gramkow, Claus
2001-01-01
In this paper two common approaches to averaging rotations are compared to a more advanced approach based on a Riemannian metric. Very often the barycenter of the quaternions or matrices that represent the rotations are used as an estimate of the mean. These methods neglect that rotations belong...
Covariant approximation averaging
Shintani, Eigo; Blum, Thomas; Izubuchi, Taku; Jung, Chulwoo; Lehner, Christoph
2014-01-01
We present a new class of statistical error reduction techniques for Monte-Carlo simulations. Using covariant symmetries, we show that correlation functions can be constructed from inexpensive approximations without introducing any systematic bias in the final result. We introduce a new class of covariant approximation averaging techniques, known as all-mode averaging (AMA), in which the approximation takes account of contributions of all eigenmodes through the inverse of the Dirac operator computed from the conjugate gradient method with a relaxed stopping condition. In this paper we compare the performance and computational cost of our new method with traditional methods using correlation functions and masses of the pion, nucleon, and vector meson in $N_f=2+1$ lattice QCD using domain-wall fermions. This comparison indicates that AMA significantly reduces statistical errors in Monte-Carlo calculations over conventional methods for the same cost.
Negative Average Preference Utilitarianism
Directory of Open Access Journals (Sweden)
Roger Chao
2012-03-01
Full Text Available For many philosophers working in the area of Population Ethics, it seems that either they have to confront the Repugnant Conclusion (where they are forced to the conclusion of creating massive amounts of lives barely worth living, or they have to confront the Non-Identity Problem (where no one is seemingly harmed as their existence is dependent on the “harmful” event that took place. To them it seems there is no escape, they either have to face one problem or the other. However, there is a way around this, allowing us to escape the Repugnant Conclusion, by using what I will call Negative Average Preference Utilitarianism (NAPU – which though similar to anti-frustrationism, has some important differences in practice. Current “positive” forms of utilitarianism have struggled to deal with the Repugnant Conclusion, as their theory actually entails this conclusion; however, it seems that a form of Negative Average Preference Utilitarianism (NAPU easily escapes this dilemma (it never even arises within it.
Roussotte, Florence F; Jahanshad, Neda; Hibar, Derrek P; Thompson, Paul M
2015-06-01
Dopamine D2 receptors mediate the rewarding effects of many drugs of abuse. In humans, several polymorphisms in DRD2, the gene encoding these receptors, increase our genetic risk for developing addictive disorders. Here, we examined one of the most frequently studied candidate variant for addiction in DRD2 for association with brain structure. We tested whether this variant showed associations with regional brain volumes across two independent elderly cohorts, totaling 1,032 subjects. We first examined a large sample of 738 elderly participants with neuroimaging and genetic data from the Alzheimer's Disease Neuroimaging Initiative (ADNI1). We hypothesized that this addiction-related polymorphism would be associated with structural brain differences in regions previously implicated in familial vulnerability for drug dependence. Then, we assessed the generalizability of our findings by testing this polymorphism in a non-overlapping replication sample of 294 elderly subjects from a continuation of the first ADNI project (ADNI2) to minimize the risk of reporting false positive results. In both cohorts, the minor allele-previously linked with increased risk for addiction-was associated with larger volumes in various brain regions implicated in reward processing. These findings suggest that neuroanatomical phenotypes associated with familial vulnerability for drug dependence may be partially mediated by DRD2 genotype.
Dynamic Multiscale Averaging (DMA) of Turbulent Flow
Energy Technology Data Exchange (ETDEWEB)
Richard W. Johnson
2012-09-01
A new approach called dynamic multiscale averaging (DMA) for computing the effects of turbulent flow is described. The new method encompasses multiple applications of temporal and spatial averaging, that is, multiscale operations. Initially, a direct numerical simulation (DNS) is performed for a relatively short time; it is envisioned that this short time should be long enough to capture several fluctuating time periods of the smallest scales. The flow field variables are subject to running time averaging during the DNS. After the relatively short time, the time-averaged variables are volume averaged onto a coarser grid. Both time and volume averaging of the describing equations generate correlations in the averaged equations. These correlations are computed from the flow field and added as source terms to the computation on the next coarser mesh. They represent coupling between the two adjacent scales. Since they are computed directly from first principles, there is no modeling involved. However, there is approximation involved in the coupling correlations as the flow field has been computed for only a relatively short time. After the time and spatial averaging operations are applied at a given stage, new computations are performed on the next coarser mesh using a larger time step. The process continues until the coarsest scale needed is reached. New correlations are created for each averaging procedure. The number of averaging operations needed is expected to be problem dependent. The new DMA approach is applied to a relatively low Reynolds number flow in a square duct segment. Time-averaged stream-wise velocity and vorticity contours from the DMA approach appear to be very similar to a full DNS for a similar flow reported in the literature. Expected symmetry for the final results is produced for the DMA method. The results obtained indicate that DMA holds significant potential in being able to accurately compute turbulent flow without modeling for practical
Messori, Andrea
2016-08-01
Several cases of expensive drugs designed for large patient populations (e.g. sofosbuvir) have raised a complex question in terms of drug pricing. Even assuming value-based pricing, the treatment with these drugs of all eligible patients would have an immense budgetary impact, which is unsustainable also for the richest countries. This raises the need to reduce the prices of these agents in comparison with those suggested by the value-based approach and to devise new pricing methods that can achieve this goal. The present study discusses in detail the following two methods: (i) The approach based on setting nation-wide budget thresholds for individual innovative agents in which a fixed proportion of the historical pharmaceutical expenditure represents the maximum budget attributable to an innovative treatment; (ii) The approach based on nation-wide price-volume agreements in which drug prices are progressively reduced as more patients receive the treatment. The first approach has been developed in the USA by the Institute for Clinical and Economic Review and has been applied to PCSK9 inhibitors (alirocumab and evolocumab). The second approach has been designed for the Italian market and has found a systematic application to manage the price of ranibizumab, sofosbuvir, and PCSK9 inhibitors. While, in the past, price-volume agreements have been applied only on an empirical basis (i.e. in the absence of any quantitative theoretical rule), more recently some explicit mathematical models have been described. The performance of these models is now being evaluated on the basis of the real-world experiences conducted in some European countries, especially Italy.
Physical Theories with Average Symmetry
Alamino, Roberto C.
2013-01-01
This Letter probes the existence of physical laws invariant only in average when subjected to some transformation. The concept of a symmetry transformation is broadened to include corruption by random noise and average symmetry is introduced by considering functions which are invariant only in average under these transformations. It is then shown that actions with average symmetry obey a modified version of Noether's Theorem with dissipative currents. The relation of this with possible violat...
Average Convexity in Communication Situations
Slikker, M.
1998-01-01
In this paper we study inheritance properties of average convexity in communication situations. We show that the underlying graph ensures that the graphrestricted game originating from an average convex game is average convex if and only if every subgraph associated with a component of the underlyin
DEFF Research Database (Denmark)
Sunesen, Vibeke Hougaard; Vedelsdal, Rune; Kristensen, Henning Gjelstrup
2005-01-01
The influence of liquid intake and a lipid-rich meal on the bioavailability of a lipophilic drug was investigated. Danazol was used as the model substance. In a randomized four-way crossover study eight healthy male volunteers received four different treatments with danazol at 2-week intervals....... The Standard oral treatment consisted of 200 ml water and one capsule containing 100mg danazol, three 500 mg paracetamol tablets and two 500 mg sulfasalazine tablets. Paracetamol and sulfasalazine were used as markers for gastric emptying and small intestinal transit times. Intake of danazol with a lipid......-rich meal or extra 800 ml water increased the bioavailability by 400 and 55%, respectively. Gastric emptying times increased in the following order: Standard...
Sampling Based Average Classifier Fusion
Directory of Open Access Journals (Sweden)
Jian Hou
2014-01-01
fusion algorithms have been proposed in literature, average fusion is almost always selected as the baseline for comparison. Little is done on exploring the potential of average fusion and proposing a better baseline. In this paper we empirically investigate the behavior of soft labels and classifiers in average fusion. As a result, we find that; by proper sampling of soft labels and classifiers, the average fusion performance can be evidently improved. This result presents sampling based average fusion as a better baseline; that is, a newly proposed classifier fusion algorithm should at least perform better than this baseline in order to demonstrate its effectiveness.
Physical Theories with Average Symmetry
Alamino, Roberto C
2013-01-01
This Letter probes the existence of physical laws invariant only in average when subjected to some transformation. The concept of a symmetry transformation is broadened to include corruption by random noise and average symmetry is introduced by considering functions which are invariant only in average under these transformations. It is then shown that actions with average symmetry obey a modified version of Noether's Theorem with dissipative currents. The relation of this with possible violations of physical symmetries, as for instance Lorentz invariance in some quantum gravity theories, is briefly commented.
Quantized average consensus with delay
Jafarian, Matin; De Persis, Claudio
2012-01-01
Average consensus problem is a special case of cooperative control in which the agents of the network asymptotically converge to the average state (i.e., position) of the network by transferring information via a communication topology. One of the issues of the large scale networks is the cost of co
Innovative Drug Injection via Laser Induced Plasma
Han, Tae-hee; Yoh, Jack J.
2010-10-01
A laser based needle-free liquid drug injection device has been developed. A laser beam is focused inside the liquid contained in the rubber chamber of micro scale. The focused laser beam causes explosive bubble growth and the sudden volume increase in a sealed chamber drives a microjet of liquid drug through the micronozzle. The exit diameter of the nozzle is 125 um and the injected microjet reaches an average velocity of 264 m/s. This device adds the time-varying feature of microjet to the current state of liquid injection for drug delivery.
Gaussian moving averages and semimartingales
DEFF Research Database (Denmark)
Basse-O'Connor, Andreas
2008-01-01
In the present paper we study moving averages (also known as stochastic convolutions) driven by a Wiener process and with a deterministic kernel. Necessary and sufficient conditions on the kernel are provided for the moving average to be a semimartingale in its natural filtration. Our results...... are constructive - meaning that they provide a simple method to obtain kernels for which the moving average is a semimartingale or a Wiener process. Several examples are considered. In the last part of the paper we study general Gaussian processes with stationary increments. We provide necessary and sufficient...
Brož, Jan; Honěk, Petr; Dušek, Ladislav; Pavlík, Tomáš; Kvapil, Milan
2015-11-01
Every year official data is published which describes the care of patients with diabetes mellitus in the Czech Republic. An overall number of individuals with diabetes, the number of newly reported cases and the number of patient deaths is always specified. However this data does not allow us to identify the differences in mortality between the individual cohorts of diabetic patients in relation to therapy. Comparison of the mortality development in the periods of 2002-2006 and 2010-2013 in a representative sample of the patient population with type 2 diabetes mellitus using oral antidiabetic drugs, kept in the database of the General Health Insurance Company of the Czech Republic (VZP) which provided health care coverage for 63% of Czech population in 2013. A retrospective epidemiologic analysis. We identified all individuals in the VZP database who had a record of DM diagnosis (E10-E16 based on ICD 10) or who had any antidiabetic therapy prescribed (ATC group A10) in the periods of 2002-2008 and 2009-2013. We only selected those patients for the analysis who were treated with oral antidiabetic medicines (in the given year or the preceding years they had a record of treatment with at least one medicine from A10B group, while having no record of treatment with medicines from A10A group within both years). 237,665 individuals met the selected criteria in 2003 and 315,418 individuals in 2013. Mortality rates dropped for all age groups (from 2003-2013): for 50-59 year olds by 1.2%-0.7%; in 60-69 year olds by 2.6%-1.6%; for 70-79 year olds by 5.8%-3.5%. In 2013 mortality rates came close to the general population where for the same age groups they reached 0.6%, 1.5% and 3.4% respectively. When expressed in relative terms, the mortality among 50-59 year olds declined by 42% (Czechia by 25%), among 60-69 year olds by 39% (Czechia by 17%) and among 70-79 year olds by 40% (Czechia by 28%) from the year 2003. The decline in mortality among the patients with DM treated with
Vocal attractiveness increases by averaging.
Bruckert, Laetitia; Bestelmeyer, Patricia; Latinus, Marianne; Rouger, Julien; Charest, Ian; Rousselet, Guillaume A; Kawahara, Hideki; Belin, Pascal
2010-01-26
Vocal attractiveness has a profound influence on listeners-a bias known as the "what sounds beautiful is good" vocal attractiveness stereotype [1]-with tangible impact on a voice owner's success at mating, job applications, and/or elections. The prevailing view holds that attractive voices are those that signal desirable attributes in a potential mate [2-4]-e.g., lower pitch in male voices. However, this account does not explain our preferences in more general social contexts in which voices of both genders are evaluated. Here we show that averaging voices via auditory morphing [5] results in more attractive voices, irrespective of the speaker's or listener's gender. Moreover, we show that this phenomenon is largely explained by two independent by-products of averaging: a smoother voice texture (reduced aperiodicities) and a greater similarity in pitch and timbre with the average of all voices (reduced "distance to mean"). These results provide the first evidence for a phenomenon of vocal attractiveness increases by averaging, analogous to a well-established effect of facial averaging [6, 7]. They highlight prototype-based coding [8] as a central feature of voice perception, emphasizing the similarity in the mechanisms of face and voice perception.
Averaged Electroencephalic Audiometry in Infants
Lentz, William E.; McCandless, Geary A.
1971-01-01
Normal, preterm, and high-risk infants were tested at 1, 3, 6, and 12 months of age using averaged electroencephalic audiometry (AEA) to determine the usefulness of AEA as a measurement technique for assessing auditory acuity in infants, and to delineate some of the procedural and technical problems often encountered. (KW)
Ergodic averages via dominating processes
DEFF Research Database (Denmark)
Møller, Jesper; Mengersen, Kerrie
2006-01-01
We show how the mean of a monotone function (defined on a state space equipped with a partial ordering) can be estimated, using ergodic averages calculated from upper and lower dominating processes of a stationary irreducible Markov chain. In particular, we do not need to simulate the stationary ...
High average power supercontinuum sources
Indian Academy of Sciences (India)
J C Travers
2010-11-01
The physical mechanisms and basic experimental techniques for the creation of high average spectral power supercontinuum sources is briefly reviewed. We focus on the use of high-power ytterbium-doped fibre lasers as pump sources, and the use of highly nonlinear photonic crystal fibres as the nonlinear medium. The most common experimental arrangements are described, including both continuous wave fibre laser systems with over 100 W pump power, and picosecond mode-locked, master oscillator power fibre amplifier systems, with over 10 kW peak pump power. These systems can produce broadband supercontinua with over 50 and 1 mW/nm average spectral power, respectively. Techniques for numerical modelling of the supercontinuum sources are presented and used to illustrate some supercontinuum dynamics. Some recent experimental results are presented.
Dependability in Aggregation by Averaging
Jesus, Paulo; Almeida, Paulo Sérgio
2010-01-01
Aggregation is an important building block of modern distributed applications, allowing the determination of meaningful properties (e.g. network size, total storage capacity, average load, majorities, etc.) that are used to direct the execution of the system. However, the majority of the existing aggregation algorithms exhibit relevant dependability issues, when prospecting their use in real application environments. In this paper, we reveal some dependability issues of aggregation algorithms based on iterative averaging techniques, giving some directions to solve them. This class of algorithms is considered robust (when compared to common tree-based approaches), being independent from the used routing topology and providing an aggregation result at all nodes. However, their robustness is strongly challenged and their correctness often compromised, when changing the assumptions of their working environment to more realistic ones. The correctness of this class of algorithms relies on the maintenance of a funda...
Measuring Complexity through Average Symmetry
Alamino, Roberto C.
2015-01-01
This work introduces a complexity measure which addresses some conflicting issues between existing ones by using a new principle - measuring the average amount of symmetry broken by an object. It attributes low (although different) complexity to either deterministic or random homogeneous densities and higher complexity to the intermediate cases. This new measure is easily computable, breaks the coarse graining paradigm and can be straightforwardly generalised, including to continuous cases an...
Mirror averaging with sparsity priors
Dalalyan, Arnak
2010-01-01
We consider the problem of aggregating the elements of a (possibly infinite) dictionary for building a decision procedure, that aims at minimizing a given criterion. Along with the dictionary, an independent identically distributed training sample is available, on which the performance of a given procedure can be tested. In a fairly general set-up, we establish an oracle inequality for the Mirror Averaging aggregate based on any prior distribution. This oracle inequality is applied in the context of sparse coding for different problems of statistics and machine learning such as regression, density estimation and binary classification.
40 CFR 80.1238 - How is a refinery's or importer's average benzene concentration determined?
2010-07-01
... average benzene concentration determined? 80.1238 Section 80.1238 Protection of Environment ENVIRONMENTAL... concentration determined? (a) The average benzene concentration of gasoline produced at a refinery or imported...: ER26FE07.012 Where: Bavg = Average benzene concentration for the applicable averaging period (volume...
Assessment of the Price-Volume Agreement Program in South Korea.
Han, Euna; Park, Sun-Young; Lee, Eui-Kyung
2016-10-01
The Price-Volume Agreement Program (PVAP) was promulgated in 2007 in South Korea as the first attempt to adjust drug pricing according to total consumption in order to contain drug expenditure. This study was designed to assess the impact of the PVAP on diabetes drug expenditure for a period of a 10-year period (2003-2012) using claims data from the National Health Insurance Service. We estimated a multilevel mixed-effects linear regression model by comparing the level of total monthly diabetes drug expenditure for drugs subject to PVAP and existing drugs after adjusting the average differences in drug expenditure before and after the PVAP. The monthly total expenditure for drugs that were newly listed through the PVAP (negotiation drugs) was 7.03% higher on average compared to that for existing drugs, controlling for the baseline differences in expenditure before and after the PVAP. This increase was observed in all four subgroups of diabetes drugs, including sitagliptin, vildagliptin, exenatide, and others. The growth rate of total diabetes drug expenditure was reduced after the PVAP despite the sustained escalation of expenditure levels, which may imply that the PVAP has the potential to be an effective tool for drug expenditure control in the long term. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
Institute of Scientific and Technical Information of China (English)
李日; 王健; 周黎明; 潘红
2014-01-01
采用欧拉方法和体积平均思想，建立了以液相为主相、等轴晶和柱状晶视为两类不同第二相的三相模型，耦合凝固过程质量、动量、能量、溶质的守恒方程和晶粒的传输方程.以Al-4.7 wt.%Cu二元合金铸锭为例，模拟了合金铸锭二维的流场、温度场、溶质场、柱状晶向等轴晶转变过程以及等轴晶的沉积过程，并将模拟的铸锭组织和偏析结果与实验所得结果对比.温度场、流场和组织的模拟结果与理论基本一致，但由于模型没有考虑收缩以及浇注时的强迫对流，导致铸锭外层的偏析模拟值比实测值低，内层的模拟值比实测值高.所以收缩和逆偏析在模拟中是不可忽略的，这也是本文模型的改进方向.另外在所得模拟结果的基础上分析了体积平均法计算铸锭凝固过程的优点和不足之处.%Adopting the Euler and the volume averaging methods, a three-phase mathematical model with parent melt as the primary phase, columnar dendrites and equiaxed grains as two different secondary phases is developed, and the coupled macroscopic mass, momentum, energy and species conservation equations are obtained separately. Taking the Al-4.7 wt%Cu binary alloy ingots for example, the flow field, temperature field, solute field, columnar-to-equiaxed-transition and grain sedimentation in two-dimension are simulated, and the simulated result of ingot and macrosegregation result are compared with their experimental values. The simulation results of temperature field, flow field and structure are basically consistent with the theoretical results, but the result of solute field shows that the simulated values is lower than the measured value on the edge, this is because the model does not take the shrinkage and forced convection into account, and the inner results is higher than the results on edge. The shrinkage and inverse segregation therefore should not be neglected. This model are still
Patient's Guide to Aerosol Drug Delivery
... Table of Contents Page Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 ................................................................ 1. Aerosol Drug Delivery: The Basics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. Aerosol Drugs: The Major Categories . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .12 3. Aerosol Drug Delivery Devices: Small-Volume Nebulizers . . . . . . . . . . . . .17 4. Aerosol Drug ...
A database of age-appropriate average MRI templates.
Richards, John E; Sanchez, Carmen; Phillips-Meek, Michelle; Xie, Wanze
2016-01-01
This article summarizes a life-span neurodevelopmental MRI database. The study of neurostructural development or neurofunctional development has been hampered by the lack of age-appropriate MRI reference volumes. This causes misspecification of segmented data, irregular registrations, and the absence of appropriate stereotaxic volumes. We have created the "Neurodevelopmental MRI Database" that provides age-specific reference data from 2 weeks through 89 years of age. The data are presented in fine-grained ages (e.g., 3 months intervals through 1 year; 6 months intervals through 19.5 years; 5 year intervals from 20 through 89 years). The base component of the database at each age is an age-specific average MRI template. The average MRI templates are accompanied by segmented partial volume estimates for segmenting priors, and a common stereotaxic atlas for infant, pediatric, and adult participants. The database is available online (http://jerlab.psych.sc.edu/NeurodevelopmentalMRIDatabase/).
Institute of Scientific and Technical Information of China (English)
徐帆; 杨伶俐; 毛盼盼; 喻琼丽
2014-01-01
目的：促进临床合理用药。方法调研相关文献，分析不同包装材质大输液的性质、特点及其对注射用药物的吸附性作用。结果与结论大输液作为临床治疗和静脉药物治疗不可缺少的载体或溶剂，在现代临床治疗中具有极其重要的地位，临床医务人员已逐渐开始关注药物与大输液包装材质的相容性与安全性。目前，我国医疗市场多种材质包装的大输液并存。临床医务人员应更加准确地把握不同包装材质大输液的特性，静脉用药物治疗时选择适当包装材质的大输液，以确保患者输液安全。%Objective To promote the rational drug use. Methods By investigating and consulting the related literature,the properties, characteristics and adsorptive effect on injectable drugs of the large volume parenteral solution package materials were analyzed. Results and Conclusion The large volume parenteral solution as the indispensable carrier or solvent possesses the extreme important status in the modern clinical treatment. The clinical medical staffs have gradually begin to pay close attention to the compatibility and safety of drugs and the large volume parenteral solution package materials. At present,the large volume parenteral solutions packaged by various materials coexist in the medical market of our country. The clinical medical staffs should more accurately grasp the characteristics of the large volume parenteral solutions with different package materials. Intravenous medication should select the large volume parenteral solu-tions with the proper package materials for ensuring the intravenous infusion safety of patients.
A laser based reusable microjet injector for transdermal drug delivery
Han, Tae-hee; Yoh, Jack J.
2010-05-01
A laser based needle-free liquid drug injection device has been developed. A laser beam is focused inside the liquid contained in the rubber chamber of microscale. The focused laser beam causes explosive bubble growth, and the sudden volume increase in a sealed chamber drives a microjet of liquid drug through the micronozzle. The exit diameter of a nozzle is 125 μm and the injected microjet reaches an average velocity of 264 m/s. This device adds the time-varying feature of microjet to the current state of liquid injection for drug delivery.
Institute of Scientific and Technical Information of China (English)
窦佳; 董莉; 戴睿娇
2013-01-01
目的用高效液相色谱标准曲线法测定格列吡嗪控释片的释放度。方法用C18柱；流动相：磷酸盐缓冲液（取磷酸二氢钠13.8g加水溶解并稀释至1000mL，用2mol/L氢氧化钠调pH至6.0）-甲醇（55∶45）；检测波长：225nm。采用标准曲线法测定释放度。结果格列吡嗪浓度在1.0~10.0μg/mL范围内与峰面积呈良好的线性关系，r=0.9998。平均加样回收率为100.19%，RSD=0.99%(n=5)。结论本方法灵敏度高、专属性强、准确可靠，较准确的反映了格列吡嗪控释片每4h的释放情况。%Objective A HPLC standard curve method has been established for the determination of the drug release of glipizide extended release tablets. Methods C18 column was used. The mobile phase was phosphate BS (dissolve 13.8g of sodium dihydrogen phosphate in water and dilute to 1000mL, adjust pH to 6.0 with 2mol•L-1 sodium hydroxide)-Methonal (55∶45). The detection wavelength was at 225 nm. The HPLC standard curve method was employed to determine the drug release. Results The linear range of 1.0~10.0μg/mL (r=0.9998) was obtained. The average recovery of add sample was 100.19%, RSD was 0.99%(n=5). Conclusion The method was of high sensitivity and speciifcity, accurate, reliable. The method can relfect accurately the drug release of glipizide extended release tablets every 4 hours.
A procedure to average 3D anatomical structures.
Subramanya, K; Dean, D
2000-12-01
Creating a feature-preserving average of three dimensional anatomical surfaces extracted from volume image data is a complex task. Unlike individual images, averages present right-left symmetry and smooth surfaces which give insight into typical proportions. Averaging multiple biological surface images requires careful superimposition and sampling of homologous regions. Our approach to biological surface image averaging grows out of a wireframe surface tessellation approach by Cutting et al. (1993). The surface delineating wires represent high curvature crestlines. By adding tile boundaries in flatter areas the 3D image surface is parametrized into anatomically labeled (homology mapped) grids. We extend the Cutting et al. wireframe approach by encoding the entire surface as a series of B-spline space curves. The crestline averaging algorithm developed by Cutting et al. may then be used for the entire surface. Shape preserving averaging of multiple surfaces requires careful positioning of homologous surface regions such as these B-spline space curves. We test the precision of this new procedure and its ability to appropriately position groups of surfaces in order to produce a shape-preserving average. Our result provides an average that well represents the source images and may be useful clinically as a deformable model or for animation.
2010-01-01
... 7 Agriculture 10 2010-01-01 2010-01-01 false On average. 1209.12 Section 1209.12 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS....12 On average. On average means a rolling average of production or imports during the last two...
Light shift averaging in paraffin-coated alkali vapor cells
Zhivun, Elena; Sudyka, Julia; Pustelny, Szymon; Patton, Brian; Budker, Dmitry
2015-01-01
Light shifts are an important source of noise and systematics in optically pumped magnetometers. We demonstrate that the long spin coherence time in paraffin-coated cells leads to spatial averaging of the light shifts over the entire cell volume. This renders the averaged light shift independent, under certain approximations, of the light-intensity distribution within the sensor cell. These results and the underlying mechanism can be extended to other spatially varying phenomena in anti-relaxation-coated cells with long coherence times.
Modification of averaging process in GR: Case study flat LTB
Khosravi, Shahram; Mansouri, Reza
2007-01-01
We study the volume averaging of inhomogeneous metrics within GR and discuss its shortcomings such as gauge dependence, singular behavior as a result of caustics, and causality violations. To remedy these shortcomings, we suggest some modifications to this method. As a case study we focus on the inhomogeneous model of structured FRW based on a flat LTB metric. The effect of averaging is then studied in terms of an effective backreaction fluid. This backreaction fluid turns out to behave like a dark matter component, instead of dark energy as claimed in literature.
Astuti, Valerio; Rovelli, Carlo
2016-01-01
Building on a technical result by Brunnemann and Rideout on the spectrum of the Volume operator in Loop Quantum Gravity, we show that the dimension of the space of the quadrivalent states --with finite-volume individual nodes-- describing a region with total volume smaller than $V$, has \\emph{finite} dimension, bounded by $V \\log V$. This allows us to introduce the notion of "volume entropy": the von Neumann entropy associated to the measurement of volume.
Small, Helen; Gardner, Iain; Jones, Hannah M; Davis, John; Rowland, Malcolm
2011-10-01
Acidic phospholipid binding plays an important role in determining the tissue distribution of basic drugs. This article describes the use of surface plasmon resonance to measure binding affinity (K(D)) of three basic drugs to phosphatidylserine, a major tissue acidic phospholipid. The data are incorporated into mechanistic tissue composition equations to allow prediction of the steady-state volume of distribution (V(ss)). The prediction accuracy of V(ss) using this approach is compared with the original methodology described by Rodgers et al. (J Pharm Sci 94:1259-1276), in which the binding to acidic phospholipids is calculated from the blood/plasma concentration ratio (BPR). The compounds used in this study [amlodipine, propranolol, and 3-dimethylaminomethyl-4-(4-methylsulfanyl-phenoxy)-benzenesulfonamide (UK-390957)] showed higher affinity binding to phosphatidylserine than to phosphatidylcholine. When the binding affinity to phosphatidylserine was incorporated into mechanistic tissue composition equations, the V(ss) was more accurately predicted for all three compounds by using the surface plasmon resonance measurement than by using the BPR to estimate acidic phospholipid binding affinity. The difference was particularly marked for UK-390957, a sulfonamide that has a high BPR due to binding to carbonic anhydrase. The novel approach described in this article allows the binding affinity of drugs to an acidic phospholipid (phosphatidylserine) to be measured directly and demonstrates the utility of the binding data in the prediction of V(ss).
Level sets of multiple ergodic averages
Ai-Hua, Fan; Ma, Ji-Hua
2011-01-01
We propose to study multiple ergodic averages from multifractal analysis point of view. In some special cases in the symbolic dynamics, Hausdorff dimensions of the level sets of multiple ergodic average limit are determined by using Riesz products.
Accurate Switched-Voltage voltage averaging circuit
金光, 一幸; 松本, 寛樹
2006-01-01
Abstract ###This paper proposes an accurate Switched-Voltage (SV) voltage averaging circuit. It is presented ###to compensated for NMOS missmatch error at MOS differential type voltage averaging circuit. ###The proposed circuit consists of a voltage averaging and a SV sample/hold (S/H) circuit. It can ###operate using nonoverlapping three phase clocks. Performance of this circuit is verified by PSpice ###simulations.
Spectral averaging techniques for Jacobi matrices
del Rio, Rafael; Schulz-Baldes, Hermann
2008-01-01
Spectral averaging techniques for one-dimensional discrete Schroedinger operators are revisited and extended. In particular, simultaneous averaging over several parameters is discussed. Special focus is put on proving lower bounds on the density of the averaged spectral measures. These Wegner type estimates are used to analyze stability properties for the spectral types of Jacobi matrices under local perturbations.
Average-Time Games on Timed Automata
Jurdzinski, Marcin; Trivedi, Ashutosh
2009-01-01
An average-time game is played on the infinite graph of configurations of a finite timed automaton. The two players, Min and Max, construct an infinite run of the automaton by taking turns to perform a timed transition. Player Min wants to minimise the average time per transition and player Max wants to maximise it. A solution of average-time games is presented using a reduction to average-price game on a finite graph. A direct consequence is an elementary proof of determinacy for average-tim...
Spreading of oil and the concept of average oil thickness
Energy Technology Data Exchange (ETDEWEB)
Goodman, R. [Innovative Ventures Ltd., Cochrane, AB (Canada); Quintero-Marmol, A.M. [Pemex E and P, Campeche (Mexico); Bannerman, K. [Radarsat International, Vancouver, BC (Canada); Stevenson, G. [Calgary Univ., AB (Canada)
2004-07-01
The area of on oil slick on water can be readily measured using simple techniques ranging from visual observations to satellite-based radar systems. However, it is necessary to know the volume of spilled oil in order to determine the environmental impacts and best response strategy. The volume of oil must be known to determine spill quantity, response effectiveness and weathering rates. The relationship between volume and area is the average thickness of the oil over the spill area. This paper presents the results of several experiments conducted in the Gulf of Mexico that determined if average thickness of the oil is a characteristic of a specific crude oil, independent of spill size. In order to calculate the amount of oil on water from the area of slick requires information on the oil thickness, the inhomogeneity of the oil thickness and the oil-to-water ratio in the slick if it is emulsified. Experimental data revealed that an oil slick stops spreading very quickly after the application of oil. After the equilibrium thickness has been established, the slick is very sensitive to disturbances on the water surface, such as wave action, which causes the oil circle to dissipate into several small irregular shapes. It was noted that the spill source and oceanographic conditions are both critical to the final shape of the spill. 31 refs., 2 tabs., 8 figs.
WIDTHS AND AVERAGE WIDTHS OF SOBOLEV CLASSES
Institute of Scientific and Technical Information of China (English)
刘永平; 许贵桥
2003-01-01
This paper concerns the problem of the Kolmogorov n-width, the linear n-width, the Gel'fand n-width and the Bernstein n-width of Sobolev classes of the periodicmultivariate functions in the space Lp(Td) and the average Bernstein σ-width, averageKolmogorov σ-widths, the average linear σ-widths of Sobolev classes of the multivariatequantities.
Stochastic averaging of quasi-Hamiltonian systems
Institute of Scientific and Technical Information of China (English)
朱位秋
1996-01-01
A stochastic averaging method is proposed for quasi-Hamiltonian systems (Hamiltonian systems with light dampings subject to weakly stochastic excitations). Various versions of the method, depending on whether the associated Hamiltonian systems are integrable or nonintegrable, resonant or nonresonant, are discussed. It is pointed out that the standard stochastic averaging method and the stochastic averaging method of energy envelope are special cases of the stochastic averaging method of quasi-Hamiltonian systems and that the results obtained by this method for several examples prove its effectiveness.
NOAA Average Annual Salinity (3-Zone)
California Department of Resources — The 3-Zone Average Annual Salinity Digital Geography is a digital spatial framework developed using geographic information system (GIS) technology. These salinity...
Pharmaceutical policy regarding generic drugs in Belgium.
Simoens, Steven; De Bruyn, Kristien; Bogaert, Marc; Laekeman, Gert
2005-01-01
Pressure to control pharmaceutical expenditure and price competition among pharmaceutical companies are fuelling the development of generic drug markets in EU countries. However, in Belgium, the market for generic drugs is underdeveloped compared with other countries. To promote the use of generic drugs, the government introduced a reference pricing (RP) scheme in 2001. The aim of this paper is to discuss Belgian pharmaceutical policy regarding generic drugs and to analyse how the Belgian drug market has evolved following initiation of the RP scheme. The market share held by generic drugs increased following implementation of the RP scheme. Focusing on volume, average market share (by semester) for generic drugs amounted to 2.05% of the total pharmaceutical market from January 1998 to June 2001, compared with 6.11% from July 2001 to December 2003. As new generic drugs are introduced, their market share tends to increase in the first couple of months, after which it levels off. Faced with increasing generic competition, some manufacturers have launched new variants of their original drug, thereby effectively extending the period of patent protection. Strategies consisting of price reductions in return for the abolition of prescribing conditions and the launch of new dosages or formulations appear to have been successful in maintaining the market share of original drugs. Nevertheless, the introduction of the RP scheme was associated with savings amounting to 1.8% of pharmaceutical expenditure by the third-party payer in 2001 and 2.1% in 2002. The findings of this paper indicate that the RP scheme has stimulated the Belgian generic drug market. However, existing policy has largely failed to take into account the role that physicians and pharmacists can play in stimulating generic drug use. Therefore, further development of the Belgian generic drug market seems to hinge on the creation of appropriate incentives for physicians to prescribe, and for pharmacists to
Average Transmission Probability of a Random Stack
Lu, Yin; Miniatura, Christian; Englert, Berthold-Georg
2010-01-01
The transmission through a stack of identical slabs that are separated by gaps with random widths is usually treated by calculating the average of the logarithm of the transmission probability. We show how to calculate the average of the transmission probability itself with the aid of a recurrence relation and derive analytical upper and lower…
Average sampling theorems for shift invariant subspaces
Institute of Scientific and Technical Information of China (English)
无
2000-01-01
The sampling theorem is one of the most powerful results in signal analysis. In this paper, we study the average sampling on shift invariant subspaces, e.g. wavelet subspaces. We show that if a subspace satisfies certain conditions, then every function in the subspace is uniquely determined and can be reconstructed by its local averages near certain sampling points. Examples are given.
Testing linearity against nonlinear moving average models
de Gooijer, J.G.; Brännäs, K.; Teräsvirta, T.
1998-01-01
Lagrange multiplier (LM) test statistics are derived for testing a linear moving average model against an additive smooth transition moving average model. The latter model is introduced in the paper. The small sample performance of the proposed tests are evaluated in a Monte Carlo study and compared
Averaging Einstein's equations : The linearized case
Stoeger, William R.; Helmi, Amina; Torres, Diego F.
2007-01-01
We introduce a simple and straightforward averaging procedure, which is a generalization of one which is commonly used in electrodynamics, and show that it possesses all the characteristics we require for linearized averaging in general relativity and cosmology for weak-field and perturbed FLRW situ
Averaging Einstein's equations : The linearized case
Stoeger, William R.; Helmi, Amina; Torres, Diego F.
We introduce a simple and straightforward averaging procedure, which is a generalization of one which is commonly used in electrodynamics, and show that it possesses all the characteristics we require for linearized averaging in general relativity and cosmology for weak-field and perturbed FLRW
Average excitation potentials of air and aluminium
Bogaardt, M.; Koudijs, B.
1951-01-01
By means of a graphical method the average excitation potential I may be derived from experimental data. Average values for Iair and IAl have been obtained. It is shown that in representing range/energy relations by means of Bethe's well known formula, I has to be taken as a continuously changing fu
Average Transmission Probability of a Random Stack
Lu, Yin; Miniatura, Christian; Englert, Berthold-Georg
2010-01-01
The transmission through a stack of identical slabs that are separated by gaps with random widths is usually treated by calculating the average of the logarithm of the transmission probability. We show how to calculate the average of the transmission probability itself with the aid of a recurrence relation and derive analytical upper and lower…
New results on averaging theory and applications
Cândido, Murilo R.; Llibre, Jaume
2016-08-01
The usual averaging theory reduces the computation of some periodic solutions of a system of ordinary differential equations, to find the simple zeros of an associated averaged function. When one of these zeros is not simple, i.e., the Jacobian of the averaged function in it is zero, the classical averaging theory does not provide information about the periodic solution associated to a non-simple zero. Here we provide sufficient conditions in order that the averaging theory can be applied also to non-simple zeros for studying their associated periodic solutions. Additionally, we do two applications of this new result for studying the zero-Hopf bifurcation in the Lorenz system and in the Fitzhugh-Nagumo system.
Analogue Divider by Averaging a Triangular Wave
Selvam, Krishnagiri Chinnathambi
2017-08-01
A new analogue divider circuit by averaging a triangular wave using operational amplifiers is explained in this paper. The triangle wave averaging analog divider using operational amplifiers is explained here. The reference triangular waveform is shifted from zero voltage level up towards positive power supply voltage level. Its positive portion is obtained by a positive rectifier and its average value is obtained by a low pass filter. The same triangular waveform is shifted from zero voltage level to down towards negative power supply voltage level. Its negative portion is obtained by a negative rectifier and its average value is obtained by another low pass filter. Both the averaged voltages are combined in a summing amplifier and the summed voltage is given to an op-amp as negative input. This op-amp is configured to work in a negative closed environment. The op-amp output is the divider output.
Cosmological Measures without Volume Weighting
Page, Don N
2008-01-01
Many cosmologists (myself included) have advocated volume weighting for the cosmological measure problem, weighting spatial hypersurfaces by their volume. However, this often leads to the Boltzmann brain problem, that almost all observations would be by momentary Boltzmann brains that arise very briefly as quantum fluctuations in the late universe when it has expanded to a huge size, so that our observations (too ordered for Boltzmann brains) would be highly atypical and unlikely. Here it is suggested that volume weighting may be a mistake. Volume averaging is advocated as an alternative. One consequence would be a loss of the argument for eternal inflation.
Average-passage flow model development
Adamczyk, John J.; Celestina, Mark L.; Beach, Tim A.; Kirtley, Kevin; Barnett, Mark
1989-01-01
A 3-D model was developed for simulating multistage turbomachinery flows using supercomputers. This average passage flow model described the time averaged flow field within a typical passage of a bladed wheel within a multistage configuration. To date, a number of inviscid simulations were executed to assess the resolution capabilities of the model. Recently, the viscous terms associated with the average passage model were incorporated into the inviscid computer code along with an algebraic turbulence model. A simulation of a stage-and-one-half, low speed turbine was executed. The results of this simulation, including a comparison with experimental data, is discussed.
FREQUENTIST MODEL AVERAGING ESTIMATION: A REVIEW
Institute of Scientific and Technical Information of China (English)
Haiying WANG; Xinyu ZHANG; Guohua ZOU
2009-01-01
In applications, the traditional estimation procedure generally begins with model selection.Once a specific model is selected, subsequent estimation is conducted under the selected model without consideration of the uncertainty from the selection process. This often leads to the underreporting of variability and too optimistic confidence sets. Model averaging estimation is an alternative to this procedure, which incorporates model uncertainty into the estimation process. In recent years, there has been a rising interest in model averaging from the frequentist perspective, and some important progresses have been made. In this paper, the theory and methods on frequentist model averaging estimation are surveyed. Some future research topics are also discussed.
Averaging of Backscatter Intensities in Compounds
Donovan, John J.; Pingitore, Nicholas E.; Westphal, Andrew J.
2002-01-01
Low uncertainty measurements on pure element stable isotope pairs demonstrate that mass has no influence on the backscattering of electrons at typical electron microprobe energies. The traditional prediction of average backscatter intensities in compounds using elemental mass fractions is improperly grounded in mass and thus has no physical basis. We propose an alternative model to mass fraction averaging, based of the number of electrons or protons, termed “electron fraction,” which predicts backscatter yield better than mass fraction averaging. PMID:27446752
Experimental Demonstration of Squeezed State Quantum Averaging
Lassen, Mikael; Sabuncu, Metin; Filip, Radim; Andersen, Ulrik L
2010-01-01
We propose and experimentally demonstrate a universal quantum averaging process implementing the harmonic mean of quadrature variances. The harmonic mean protocol can be used to efficiently stabilize a set of fragile squeezed light sources with statistically fluctuating noise levels. The averaged variances are prepared probabilistically by means of linear optical interference and measurement induced conditioning. We verify that the implemented harmonic mean outperforms the standard arithmetic mean strategy. The effect of quantum averaging is experimentally tested both for uncorrelated and partially correlated noise sources with sub-Poissonian shot noise or super-Poissonian shot noise characteristics.
The Average Lower Connectivity of Graphs
Directory of Open Access Journals (Sweden)
Ersin Aslan
2014-01-01
Full Text Available For a vertex v of a graph G, the lower connectivity, denoted by sv(G, is the smallest number of vertices that contains v and those vertices whose deletion from G produces a disconnected or a trivial graph. The average lower connectivity denoted by κav(G is the value (∑v∈VGsvG/VG. It is shown that this parameter can be used to measure the vulnerability of networks. This paper contains results on bounds for the average lower connectivity and obtains the average lower connectivity of some graphs.
Cosmic inhomogeneities and averaged cosmological dynamics.
Paranjape, Aseem; Singh, T P
2008-10-31
If general relativity (GR) describes the expansion of the Universe, the observed cosmic acceleration implies the existence of a "dark energy." However, while the Universe is on average homogeneous on large scales, it is inhomogeneous on smaller scales. While GR governs the dynamics of the inhomogeneous Universe, the averaged homogeneous Universe obeys modified Einstein equations. Can such modifications alone explain the acceleration? For a simple generic model with realistic initial conditions, we show the answer to be "no." Averaging effects negligibly influence the cosmological dynamics.
Changing mortality and average cohort life expectancy
DEFF Research Database (Denmark)
Schoen, Robert; Canudas-Romo, Vladimir
2005-01-01
of survivorship. An alternative aggregate measure of period mortality which has been seen as less sensitive to period changes, the cross-sectional average length of life (CAL) has been proposed as an alternative, but has received only limited empirical or analytical examination. Here, we introduce a new measure......, the average cohort life expectancy (ACLE), to provide a precise measure of the average length of life of cohorts alive at a given time. To compare the performance of ACLE with CAL and with period and cohort life expectancy, we first use population models with changing mortality. Then the four aggregate...
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Full Text Available ... Get Addicted to Drugs? Does Addiction Run in Families? Why Is It So Hard to Quit Drugs? ... Drug Use and Other People Drug Use and Families Drug Use and Kids Drug Use and Unborn ...
Discrete Averaging Relations for Micro to Macro Transition
Liu, Chenchen; Reina, Celia
2016-05-01
The well-known Hill's averaging theorems for stresses and strains as well as the so-called Hill-Mandel principle of macrohomogeneity are essential ingredients for the coupling and the consistency between the micro and macro scales in multiscale finite element procedures (FE$^2$). We show in this paper that these averaging relations hold exactly under standard finite element discretizations, even if the stress field is discontinuous across elements and the standard proofs based on the divergence theorem are no longer suitable. The discrete averaging results are derived for the three classical types of boundary conditions (affine displacement, periodic and uniform traction boundary conditions) using the properties of the shape functions and the weak form of the microscopic equilibrium equations. The analytical proofs are further verified numerically through a simple finite element simulation of an irregular representative volume element undergoing large deformations. Furthermore, the proofs are extended to include the effects of body forces and inertia, and the results are consistent with those in the smooth continuum setting. This work provides a solid foundation to apply Hill's averaging relations in multiscale finite element methods without introducing an additional error in the scale transition due to the discretization.
Institute of Scientific and Technical Information of China (English)
叶妮
2011-01-01
In favor of reference by veterinary drugs user,the article discuss the policy,framework,features and the variation of drugs category of the Veterinary Drugs Usage Guide（Chemical Medicine Volume,2010 Edition）.%论述了2010年版《兽药使用指南（化学药品卷）》编写的指导方针、构架、收载特点、品种变更,以便于兽药使用单位和个人的参阅。
Sea Surface Temperature Average_SST_Master
National Oceanic and Atmospheric Administration, Department of Commerce — Sea surface temperature collected via satellite imagery from http://www.esrl.noaa.gov/psd/data/gridded/data.noaa.ersst.html and averaged for each region using ArcGIS...
Appeals Council Requests - Average Processing Time
Social Security Administration — This dataset provides annual data from 1989 through 2015 for the average processing time (elapsed time in days) for dispositions by the Appeals Council (AC) (both...
Average Vegetation Growth 1990 - Direct Download
U.S. Geological Survey, Department of the Interior — This map layer is a grid map of 1990 average vegetation growth for Alaska and the conterminous United States. The nominal spatial resolution is 1 kilometer and the...
Average Vegetation Growth 1997 - Direct Download
U.S. Geological Survey, Department of the Interior — This map layer is a grid map of 1997 average vegetation growth for Alaska and the conterminous United States. The nominal spatial resolution is 1 kilometer and the...
Average Vegetation Growth 1992 - Direct Download
U.S. Geological Survey, Department of the Interior — This map layer is a grid map of 1992 average vegetation growth for Alaska and the conterminous United States. The nominal spatial resolution is 1 kilometer and the...
Average Vegetation Growth 2001 - Direct Download
U.S. Geological Survey, Department of the Interior — This map layer is a grid map of 2001 average vegetation growth for Alaska and the conterminous United States. The nominal spatial resolution is 1 kilometer and the...
Average Vegetation Growth 1995 - Direct Download
U.S. Geological Survey, Department of the Interior — This map layer is a grid map of 1995 average vegetation growth for Alaska and the conterminous United States. The nominal spatial resolution is 1 kilometer and the...
Average Vegetation Growth 2000 - Direct Download
U.S. Geological Survey, Department of the Interior — This map layer is a grid map of 2000 average vegetation growth for Alaska and the conterminous United States. The nominal spatial resolution is 1 kilometer and the...
Average Vegetation Growth 1998 - Direct Download
U.S. Geological Survey, Department of the Interior — This map layer is a grid map of 1998 average vegetation growth for Alaska and the conterminous United States. The nominal spatial resolution is 1 kilometer and the...
Average Vegetation Growth 1994 - Direct Download
U.S. Geological Survey, Department of the Interior — This map layer is a grid map of 1994 average vegetation growth for Alaska and the conterminous United States. The nominal spatial resolution is 1 kilometer and the...
MN Temperature Average (1961-1990) - Line
Minnesota Department of Natural Resources — This data set depicts 30-year averages (1961-1990) of monthly and annual temperatures for Minnesota. Isolines and regions were created using kriging and...
Average Vegetation Growth 1996 - Direct Download
U.S. Geological Survey, Department of the Interior — This map layer is a grid map of 1996 average vegetation growth for Alaska and the conterminous United States. The nominal spatial resolution is 1 kilometer and the...
Average Vegetation Growth 2005 - Direct Download
U.S. Geological Survey, Department of the Interior — This map layer is a grid map of 2005 average vegetation growth for Alaska and the conterminous United States. The nominal spatial resolution is 1 kilometer and the...
Average Vegetation Growth 1993 - Direct Download
U.S. Geological Survey, Department of the Interior — This map layer is a grid map of 1993 average vegetation growth for Alaska and the conterminous United States. The nominal spatial resolution is 1 kilometer and the...
MN Temperature Average (1961-1990) - Polygon
Minnesota Department of Natural Resources — This data set depicts 30-year averages (1961-1990) of monthly and annual temperatures for Minnesota. Isolines and regions were created using kriging and...
Spacetime Average Density (SAD) Cosmological Measures
Page, Don N
2014-01-01
The measure problem of cosmology is how to obtain normalized probabilities of observations from the quantum state of the universe. This is particularly a problem when eternal inflation leads to a universe of unbounded size so that there are apparently infinitely many realizations or occurrences of observations of each of many different kinds or types, making the ratios ambiguous. There is also the danger of domination by Boltzmann Brains. Here two new Spacetime Average Density (SAD) measures are proposed, Maximal Average Density (MAD) and Biased Average Density (BAD), for getting a finite number of observation occurrences by using properties of the Spacetime Average Density (SAD) of observation occurrences to restrict to finite regions of spacetimes that have a preferred beginning or bounce hypersurface. These measures avoid Boltzmann brain domination and appear to give results consistent with other observations that are problematic for other widely used measures, such as the observation of a positive cosmolo...
A practical guide to averaging functions
Beliakov, Gleb; Calvo Sánchez, Tomasa
2016-01-01
This book offers an easy-to-use and practice-oriented reference guide to mathematical averages. It presents different ways of aggregating input values given on a numerical scale, and of choosing and/or constructing aggregating functions for specific applications. Building on a previous monograph by Beliakov et al. published by Springer in 2007, it outlines new aggregation methods developed in the interim, with a special focus on the topic of averaging aggregation functions. It examines recent advances in the field, such as aggregation on lattices, penalty-based aggregation and weakly monotone averaging, and extends many of the already existing methods, such as: ordered weighted averaging (OWA), fuzzy integrals and mixture functions. A substantial mathematical background is not called for, as all the relevant mathematical notions are explained here and reported on together with a wealth of graphical illustrations of distinct families of aggregation functions. The authors mainly focus on practical applications ...
Rotational averaging of multiphoton absorption cross sections
Energy Technology Data Exchange (ETDEWEB)
Friese, Daniel H., E-mail: daniel.h.friese@uit.no; Beerepoot, Maarten T. P.; Ruud, Kenneth [Centre for Theoretical and Computational Chemistry, University of Tromsø — The Arctic University of Norway, N-9037 Tromsø (Norway)
2014-11-28
Rotational averaging of tensors is a crucial step in the calculation of molecular properties in isotropic media. We present a scheme for the rotational averaging of multiphoton absorption cross sections. We extend existing literature on rotational averaging to even-rank tensors of arbitrary order and derive equations that require only the number of photons as input. In particular, we derive the first explicit expressions for the rotational average of five-, six-, and seven-photon absorption cross sections. This work is one of the required steps in making the calculation of these higher-order absorption properties possible. The results can be applied to any even-rank tensor provided linearly polarized light is used.
Rotational averaging of multiphoton absorption cross sections
Friese, Daniel H.; Beerepoot, Maarten T. P.; Ruud, Kenneth
2014-11-01
Rotational averaging of tensors is a crucial step in the calculation of molecular properties in isotropic media. We present a scheme for the rotational averaging of multiphoton absorption cross sections. We extend existing literature on rotational averaging to even-rank tensors of arbitrary order and derive equations that require only the number of photons as input. In particular, we derive the first explicit expressions for the rotational average of five-, six-, and seven-photon absorption cross sections. This work is one of the required steps in making the calculation of these higher-order absorption properties possible. The results can be applied to any even-rank tensor provided linearly polarized light is used.
Monthly snow/ice averages (ISCCP)
National Aeronautics and Space Administration — September Arctic sea ice is now declining at a rate of 11.5 percent per decade, relative to the 1979 to 2000 average. Data from NASA show that the land ice sheets in...
Average Annual Precipitation (PRISM model) 1961 - 1990
U.S. Geological Survey, Department of the Interior — This map layer shows polygons of average annual precipitation in the contiguous United States, for the climatological period 1961-1990. Parameter-elevation...
Symmetric Euler orientation representations for orientational averaging.
Mayerhöfer, Thomas G
2005-09-01
A new kind of orientation representation called symmetric Euler orientation representation (SEOR) is presented. It is based on a combination of the conventional Euler orientation representations (Euler angles) and Hamilton's quaternions. The properties of the SEORs concerning orientational averaging are explored and compared to those of averaging schemes that are based on conventional Euler orientation representations. To that aim, the reflectance of a hypothetical polycrystalline material with orthorhombic crystal symmetry was calculated. The calculation was carried out according to the average refractive index theory (ARIT [T.G. Mayerhöfer, Appl. Spectrosc. 56 (2002) 1194]). It is shown that the use of averaging schemes based on conventional Euler orientation representations leads to a dependence of the result from the specific Euler orientation representation that was utilized and from the initial position of the crystal. The latter problem can be overcome partly by the introduction of a weighing factor, but only for two-axes-type Euler orientation representations. In case of a numerical evaluation of the average, a residual difference remains also if a two-axes type Euler orientation representation is used despite of the utilization of a weighing factor. In contrast, this problem does not occur if a symmetric Euler orientation representation is used as a matter of principle, while the result of the averaging for both types of orientation representations converges with increasing number of orientations considered in the numerical evaluation. Additionally, the use of a weighing factor and/or non-equally spaced steps in the numerical evaluation of the average is not necessary. The symmetrical Euler orientation representations are therefore ideally suited for the use in orientational averaging procedures.
Cosmic Inhomogeneities and the Average Cosmological Dynamics
Paranjape, Aseem; Singh, T. P.
2008-01-01
If general relativity (GR) describes the expansion of the Universe, the observed cosmic acceleration implies the existence of a `dark energy'. However, while the Universe is on average homogeneous on large scales, it is inhomogeneous on smaller scales. While GR governs the dynamics of the \\emph{in}homogeneous Universe, the averaged \\emph{homogeneous} Universe obeys modified Einstein equations. Can such modifications alone explain the acceleration? For a simple generic model with realistic ini...
Average Bandwidth Allocation Model of WFQ
Directory of Open Access Journals (Sweden)
Tomáš Balogh
2012-01-01
Full Text Available We present a new iterative method for the calculation of average bandwidth assignment to traffic flows using a WFQ scheduler in IP based NGN networks. The bandwidth assignment calculation is based on the link speed, assigned weights, arrival rate, and average packet length or input rate of the traffic flows. We prove the model outcome with examples and simulation results using NS2 simulator.
Averaging processes in granular flows driven by gravity
Rossi, Giulia; Armanini, Aronne
2016-04-01
One of the more promising theoretical frames to analyse the two-phase granular flows is offered by the similarity of their rheology with the kinetic theory of gases [1]. Granular flows can be considered a macroscopic equivalent of the molecular case: the collisions among molecules are compared to the collisions among grains at a macroscopic scale [2,3]. However there are important statistical differences in dealing with the two applications. In the two-phase fluid mechanics, there are two main types of average: the phasic average and the mass weighed average [4]. The kinetic theories assume that the size of atoms is so small, that the number of molecules in a control volume is infinite. With this assumption, the concentration (number of particles n) doesn't change during the averaging process and the two definitions of average coincide. This hypothesis is no more true in granular flows: contrary to gases, the dimension of a single particle becomes comparable to that of the control volume. For this reason, in a single realization the number of grain is constant and the two averages coincide; on the contrary, for more than one realization, n is no more constant and the two types of average lead to different results. Therefore, the ensamble average used in the standard kinetic theory (which usually is the phasic average) is suitable for the single realization, but not for several realization, as already pointed out in [5,6]. In the literature, three main length scales have been identified [7]: the smallest is the particles size, the intermediate consists in the local averaging (in order to describe some instability phenomena or secondary circulation) and the largest arises from phenomena such as large eddies in turbulence. Our aim is to solve the intermediate scale, by applying the mass weighted average, when dealing with more than one realizations. This statistical approach leads to additional diffusive terms in the continuity equation: starting from experimental
Averaged controllability of parameter dependent conservative semigroups
Lohéac, Jérôme; Zuazua, Enrique
2017-02-01
We consider the problem of averaged controllability for parameter depending (either in a discrete or continuous fashion) control systems, the aim being to find a control, independent of the unknown parameters, so that the average of the states is controlled. We do it in the context of conservative models, both in an abstract setting and also analysing the specific examples of the wave and Schrödinger equations. Our first result is of perturbative nature. Assuming the averaging probability measure to be a small parameter-dependent perturbation (in a sense that we make precise) of an atomic measure given by a Dirac mass corresponding to a specific realisation of the system, we show that the averaged controllability property is achieved whenever the system corresponding to the support of the Dirac is controllable. Similar tools can be employed to obtain averaged versions of the so-called Ingham inequalities. Particular attention is devoted to the 1d wave equation in which the time-periodicity of solutions can be exploited to obtain more precise results, provided the parameters involved satisfy Diophantine conditions ensuring the lack of resonances.
Average Temperatures in the Southwestern United States, 2000-2015 Versus Long-Term Average
U.S. Environmental Protection Agency — This indicator shows how the average air temperature from 2000 to 2015 has differed from the long-term average (1895–2015). To provide more detailed information,...
Cosmic structure, averaging and dark energy
Wiltshire, David L
2013-01-01
These lecture notes review the theoretical problems associated with coarse-graining the observed inhomogeneous structure of the universe at late epochs, of describing average cosmic evolution in the presence of growing inhomogeneity, and of relating average quantities to physical observables. In particular, a detailed discussion of the timescape scenario is presented. In this scenario, dark energy is realized as a misidentification of gravitational energy gradients which result from gradients in the kinetic energy of expansion of space, in the presence of density and spatial curvature gradients that grow large with the growth of structure. The phenomenology and observational tests of the timescape model are discussed in detail, with updated constraints from Planck satellite data. In addition, recent results on the variation of the Hubble expansion on < 100/h Mpc scales are discussed. The spherically averaged Hubble law is significantly more uniform in the rest frame of the Local Group of galaxies than in t...
Books average previous decade of economic misery.
Directory of Open Access Journals (Sweden)
R Alexander Bentley
Full Text Available For the 20(th century since the Depression, we find a strong correlation between a 'literary misery index' derived from English language books and a moving average of the previous decade of the annual U.S. economic misery index, which is the sum of inflation and unemployment rates. We find a peak in the goodness of fit at 11 years for the moving average. The fit between the two misery indices holds when using different techniques to measure the literary misery index, and this fit is significantly better than other possible correlations with different emotion indices. To check the robustness of the results, we also analysed books written in German language and obtained very similar correlations with the German economic misery index. The results suggest that millions of books published every year average the authors' shared economic experiences over the past decade.
Benchmarking statistical averaging of spectra with HULLAC
Klapisch, Marcel; Busquet, Michel
2008-11-01
Knowledge of radiative properties of hot plasmas is important for ICF, astrophysics, etc When mid-Z or high-Z elements are present, the spectra are so complex that one commonly uses statistically averaged description of atomic systems [1]. In a recent experiment on Fe[2], performed under controlled conditions, high resolution transmission spectra were obtained. The new version of HULLAC [3] allows the use of the same model with different levels of details/averaging. We will take advantage of this feature to check the effect of averaging with comparison with experiment. [1] A Bar-Shalom, J Oreg, and M Klapisch, J. Quant. Spectros. Rad. Transf. 65, 43 (2000). [2] J. E. Bailey, G. A. Rochau, C. A. Iglesias et al., Phys. Rev. Lett. 99, 265002-4 (2007). [3]. M. Klapisch, M. Busquet, and A. Bar-Shalom, AIP Conference Proceedings 926, 206-15 (2007).
Stochastic Averaging and Stochastic Extremum Seeking
Liu, Shu-Jun
2012-01-01
Stochastic Averaging and Stochastic Extremum Seeking develops methods of mathematical analysis inspired by the interest in reverse engineering and analysis of bacterial convergence by chemotaxis and to apply similar stochastic optimization techniques in other environments. The first half of the text presents significant advances in stochastic averaging theory, necessitated by the fact that existing theorems are restricted to systems with linear growth, globally exponentially stable average models, vanishing stochastic perturbations, and prevent analysis over infinite time horizon. The second half of the text introduces stochastic extremum seeking algorithms for model-free optimization of systems in real time using stochastic perturbations for estimation of their gradients. Both gradient- and Newton-based algorithms are presented, offering the user the choice between the simplicity of implementation (gradient) and the ability to achieve a known, arbitrary convergence rate (Newton). The design of algorithms...
Books average previous decade of economic misery.
Bentley, R Alexander; Acerbi, Alberto; Ormerod, Paul; Lampos, Vasileios
2014-01-01
For the 20(th) century since the Depression, we find a strong correlation between a 'literary misery index' derived from English language books and a moving average of the previous decade of the annual U.S. economic misery index, which is the sum of inflation and unemployment rates. We find a peak in the goodness of fit at 11 years for the moving average. The fit between the two misery indices holds when using different techniques to measure the literary misery index, and this fit is significantly better than other possible correlations with different emotion indices. To check the robustness of the results, we also analysed books written in German language and obtained very similar correlations with the German economic misery index. The results suggest that millions of books published every year average the authors' shared economic experiences over the past decade.
High Average Power Yb:YAG Laser
Energy Technology Data Exchange (ETDEWEB)
Zapata, L E; Beach, R J; Payne, S A
2001-05-23
We are working on a composite thin-disk laser design that can be scaled as a source of high brightness laser power for tactical engagement and other high average power applications. The key component is a diffusion-bonded composite comprising a thin gain-medium and thicker cladding that is strikingly robust and resolves prior difficulties with high average power pumping/cooling and the rejection of amplified spontaneous emission (ASE). In contrast to high power rods or slabs, the one-dimensional nature of the cooling geometry and the edge-pump geometry scale gracefully to very high average power. The crucial design ideas have been verified experimentally. Progress this last year included: extraction with high beam quality using a telescopic resonator, a heterogeneous thin film coating prescription that meets the unusual requirements demanded by this laser architecture, thermal management with our first generation cooler. Progress was also made in design of a second-generation laser.
The modulated average structure of mullite.
Birkenstock, Johannes; Petříček, Václav; Pedersen, Bjoern; Schneider, Hartmut; Fischer, Reinhard X
2015-06-01
Homogeneous and inclusion-free single crystals of 2:1 mullite (Al(4.8)Si(1.2)O(9.6)) grown by the Czochralski technique were examined by X-ray and neutron diffraction methods. The observed diffuse scattering together with the pattern of satellite reflections confirm previously published data and are thus inherent features of the mullite structure. The ideal composition was closely met as confirmed by microprobe analysis (Al(4.82 (3))Si(1.18 (1))O(9.59 (5))) and by average structure refinements. 8 (5) to 20 (13)% of the available Si was found in the T* position of the tetrahedra triclusters. The strong tendencey for disorder in mullite may be understood from considerations of hypothetical superstructures which would have to be n-fivefold with respect to the three-dimensional average unit cell of 2:1 mullite and n-fourfold in case of 3:2 mullite. In any of these the possible arrangements of the vacancies and of the tetrahedral units would inevitably be unfavorable. Three directions of incommensurate modulations were determined: q1 = [0.3137 (2) 0 ½], q2 = [0 0.4021 (5) 0.1834 (2)] and q3 = [0 0.4009 (5) -0.1834 (2)]. The one-dimensional incommensurately modulated crystal structure associated with q1 was refined for the first time using the superspace approach. The modulation is dominated by harmonic occupational modulations of the atoms in the di- and the triclusters of the tetrahedral units in mullite. The modulation amplitudes are small and the harmonic character implies that the modulated structure still represents an average structure in the overall disordered arrangement of the vacancies and of the tetrahedral structural units. In other words, when projecting the local assemblies at the scale of a few tens of average mullite cells into cells determined by either one of the modulation vectors q1, q2 or q3 a weak average modulation results with slightly varying average occupation factors for the tetrahedral units. As a result, the real
A singularity theorem based on spatial averages
Indian Academy of Sciences (India)
J M M Senovilla
2007-07-01
Inspired by Raychaudhuri's work, and using the equation named after him as a basic ingredient, a new singularity theorem is proved. Open non-rotating Universes, expanding everywhere with a non-vanishing spatial average of the matter variables, show severe geodesic incompletness in the past. Another way of stating the result is that, under the same conditions, any singularity-free model must have a vanishing spatial average of the energy density (and other physical variables). This is very satisfactory and provides a clear decisive difference between singular and non-singular cosmologies.
Average: the juxtaposition of procedure and context
Watson, Jane; Chick, Helen; Callingham, Rosemary
2014-09-01
This paper presents recent data on the performance of 247 middle school students on questions concerning average in three contexts. Analysis includes considering levels of understanding linking definition and context, performance across contexts, the relative difficulty of tasks, and difference in performance for male and female students. The outcomes lead to a discussion of the expectations of the curriculum and its implementation, as well as assessment, in relation to students' skills in carrying out procedures and their understanding about the meaning of average in context.
SOURCE TERMS FOR AVERAGE DOE SNF CANISTERS
Energy Technology Data Exchange (ETDEWEB)
K. L. Goluoglu
2000-06-09
The objective of this calculation is to generate source terms for each type of Department of Energy (DOE) spent nuclear fuel (SNF) canister that may be disposed of at the potential repository at Yucca Mountain. The scope of this calculation is limited to generating source terms for average DOE SNF canisters, and is not intended to be used for subsequent calculations requiring bounding source terms. This calculation is to be used in future Performance Assessment calculations, or other shielding or thermal calculations requiring average source terms.
An approximate analytical approach to resampling averages
DEFF Research Database (Denmark)
Malzahn, Dorthe; Opper, M.
2004-01-01
Using a novel reformulation, we develop a framework to compute approximate resampling data averages analytically. The method avoids multiple retraining of statistical models on the samples. Our approach uses a combination of the replica "trick" of statistical physics and the TAP approach for appr......Using a novel reformulation, we develop a framework to compute approximate resampling data averages analytically. The method avoids multiple retraining of statistical models on the samples. Our approach uses a combination of the replica "trick" of statistical physics and the TAP approach...
Grassmann Averages for Scalable Robust PCA
DEFF Research Database (Denmark)
Hauberg, Søren; Feragen, Aasa; Black, Michael J.
2014-01-01
As the collection of large datasets becomes increasingly automated, the occurrence of outliers will increase—“big data” implies “big outliers”. While principal component analysis (PCA) is often used to reduce the size of data, and scalable solutions exist, it is well-known that outliers can...... to vectors (subspaces) or elements of vectors; we focus on the latter and use a trimmed average. The resulting Trimmed Grassmann Average (TGA) is particularly appropriate for computer vision because it is robust to pixel outliers. The algorithm has low computational complexity and minimal memory requirements...
Model averaging and muddled multimodel inferences.
Cade, Brian S
2015-09-01
Three flawed practices associated with model averaging coefficients for predictor variables in regression models commonly occur when making multimodel inferences in analyses of ecological data. Model-averaged regression coefficients based on Akaike information criterion (AIC) weights have been recommended for addressing model uncertainty but they are not valid, interpretable estimates of partial effects for individual predictors when there is multicollinearity among the predictor variables. Multicollinearity implies that the scaling of units in the denominators of the regression coefficients may change across models such that neither the parameters nor their estimates have common scales, therefore averaging them makes no sense. The associated sums of AIC model weights recommended to assess relative importance of individual predictors are really a measure of relative importance of models, with little information about contributions by individual predictors compared to other measures of relative importance based on effects size or variance reduction. Sometimes the model-averaged regression coefficients for predictor variables are incorrectly used to make model-averaged predictions of the response variable when the models are not linear in the parameters. I demonstrate the issues with the first two practices using the college grade point average example extensively analyzed by Burnham and Anderson. I show how partial standard deviations of the predictor variables can be used to detect changing scales of their estimates with multicollinearity. Standardizing estimates based on partial standard deviations for their variables can be used to make the scaling of the estimates commensurate across models, a necessary but not sufficient condition for model averaging of the estimates to be sensible. A unimodal distribution of estimates and valid interpretation of individual parameters are additional requisite conditions. The standardized estimates or equivalently the t
Model averaging and muddled multimodel inferences
Cade, Brian S.
2015-01-01
Three flawed practices associated with model averaging coefficients for predictor variables in regression models commonly occur when making multimodel inferences in analyses of ecological data. Model-averaged regression coefficients based on Akaike information criterion (AIC) weights have been recommended for addressing model uncertainty but they are not valid, interpretable estimates of partial effects for individual predictors when there is multicollinearity among the predictor variables. Multicollinearity implies that the scaling of units in the denominators of the regression coefficients may change across models such that neither the parameters nor their estimates have common scales, therefore averaging them makes no sense. The associated sums of AIC model weights recommended to assess relative importance of individual predictors are really a measure of relative importance of models, with little information about contributions by individual predictors compared to other measures of relative importance based on effects size or variance reduction. Sometimes the model-averaged regression coefficients for predictor variables are incorrectly used to make model-averaged predictions of the response variable when the models are not linear in the parameters. I demonstrate the issues with the first two practices using the college grade point average example extensively analyzed by Burnham and Anderson. I show how partial standard deviations of the predictor variables can be used to detect changing scales of their estimates with multicollinearity. Standardizing estimates based on partial standard deviations for their variables can be used to make the scaling of the estimates commensurate across models, a necessary but not sufficient condition for model averaging of the estimates to be sensible. A unimodal distribution of estimates and valid interpretation of individual parameters are additional requisite conditions. The standardized estimates or equivalently the
Directory of Open Access Journals (Sweden)
G. H. de Rooij
2009-07-01
Full Text Available Current theories for water flow in porous media are valid for scales much smaller than those at which problem of public interest manifest themselves. This provides a drive for upscaled flow equations with their associated upscaled parameters. Upscaling is often achieved through volume averaging, but the solution to the resulting closure problem imposes severe restrictions to the flow conditions that limit the practical applicability. Here, the derivation of a closed expression of the effective hydraulic conductivity is forfeited to circumvent the closure problem. Thus, more limited but practical results can be derived. At the Representative Elementary Volume scale and larger scales, the gravitational potential and fluid pressure are treated as additive potentials. The necessary requirement that the superposition be maintained across scales is combined with conservation of energy during volume integration to establish consistent upscaling equations for the various heads. The power of these upscaling equations is demonstrated by the derivation of upscaled water content-matric head relationships and the resolution of an apparent paradox reported in the literature that is shown to have arisen from a violation of the superposition principle. Applying the upscaling procedure to Darcy's Law leads to the general definition of an upscaled hydraulic conductivity. By examining this definition in detail for porous media with different degrees of heterogeneity, a series of criteria is derived that must be satisfied for Darcy's Law to remain valid at a larger scale.
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Parameterized Traveling Salesman Problem: Beating the Average
Gutin, G.; Patel, V.
2016-01-01
In the traveling salesman problem (TSP), we are given a complete graph Kn together with an integer weighting w on the edges of Kn, and we are asked to find a Hamilton cycle of Kn of minimum weight. Let h(w) denote the average weight of a Hamilton cycle of Kn for the weighting w. Vizing in 1973 asked
On averaging methods for partial differential equations
Verhulst, F.
2001-01-01
The analysis of weakly nonlinear partial differential equations both qualitatively and quantitatively is emerging as an exciting eld of investigation In this report we consider specic results related to averaging but we do not aim at completeness The sections and contain important material which
Discontinuities and hysteresis in quantized average consensus
Ceragioli, Francesca; Persis, Claudio De; Frasca, Paolo
2011-01-01
We consider continuous-time average consensus dynamics in which the agents’ states are communicated through uniform quantizers. Solutions to the resulting system are defined in the Krasowskii sense and are proven to converge to conditions of ‘‘practical consensus’’. To cope with undesired chattering
Bayesian Averaging is Well-Temperated
DEFF Research Database (Denmark)
Hansen, Lars Kai
2000-01-01
Bayesian predictions are stochastic just like predictions of any other inference scheme that generalize from a finite sample. While a simple variational argument shows that Bayes averaging is generalization optimal given that the prior matches the teacher parameter distribution the situation...
A Functional Measurement Study on Averaging Numerosity
Tira, Michael D.; Tagliabue, Mariaelena; Vidotto, Giulio
2014-01-01
In two experiments, participants judged the average numerosity between two sequentially presented dot patterns to perform an approximate arithmetic task. In Experiment 1, the response was given on a 0-20 numerical scale (categorical scaling), and in Experiment 2, the response was given by the production of a dot pattern of the desired numerosity…
Generalized Jackknife Estimators of Weighted Average Derivatives
DEFF Research Database (Denmark)
Cattaneo, Matias D.; Crump, Richard K.; Jansson, Michael
With the aim of improving the quality of asymptotic distributional approximations for nonlinear functionals of nonparametric estimators, this paper revisits the large-sample properties of an important member of that class, namely a kernel-based weighted average derivative estimator. Asymptotic li...
Bootstrapping Density-Weighted Average Derivatives
DEFF Research Database (Denmark)
Cattaneo, Matias D.; Crump, Richard K.; Jansson, Michael
Employing the "small bandwidth" asymptotic framework of Cattaneo, Crump, and Jansson (2009), this paper studies the properties of a variety of bootstrap-based inference procedures associated with the kernel-based density-weighted averaged derivative estimator proposed by Powell, Stock, and Stoker...
Quantum Averaging of Squeezed States of Light
DEFF Research Database (Denmark)
Squeezing has been recognized as the main resource for quantum information processing and an important resource for beating classical detection strategies. It is therefore of high importance to reliably generate stable squeezing over longer periods of time. The averaging procedure for a single qu...
Bayesian Model Averaging for Propensity Score Analysis
Kaplan, David; Chen, Jianshen
2013-01-01
The purpose of this study is to explore Bayesian model averaging in the propensity score context. Previous research on Bayesian propensity score analysis does not take into account model uncertainty. In this regard, an internally consistent Bayesian framework for model building and estimation must also account for model uncertainty. The…
A dynamic analysis of moving average rules
Chiarella, C.; He, X.Z.; Hommes, C.H.
2006-01-01
The use of various moving average (MA) rules remains popular with financial market practitioners. These rules have recently become the focus of a number empirical studies, but there have been very few studies of financial market models where some agents employ technical trading rules of the type
Average utility maximization: A preference foundation
A.V. Kothiyal (Amit); V. Spinu (Vitalie); P.P. Wakker (Peter)
2014-01-01
textabstractThis paper provides necessary and sufficient preference conditions for average utility maximization over sequences of variable length. We obtain full generality by using a new algebraic technique that exploits the richness structure naturally provided by the variable length of the sequen
High average-power induction linacs
Energy Technology Data Exchange (ETDEWEB)
Prono, D.S.; Barrett, D.; Bowles, E.; Caporaso, G.J.; Chen, Yu-Jiuan; Clark, J.C.; Coffield, F.; Newton, M.A.; Nexsen, W.; Ravenscroft, D.
1989-03-15
Induction linear accelerators (LIAs) are inherently capable of accelerating several thousand amperes of /approximately/ 50-ns duration pulses to > 100 MeV. In this paper we report progress and status in the areas of duty factor and stray power management. These technologies are vital if LIAs are to attain high average power operation. 13 figs.
High Average Power Optical FEL Amplifiers
Ben-Zvi, I; Litvinenko, V
2005-01-01
Historically, the first demonstration of the FEL was in an amplifier configuration at Stanford University. There were other notable instances of amplifying a seed laser, such as the LLNL amplifier and the BNL ATF High-Gain Harmonic Generation FEL. However, for the most part FELs are operated as oscillators or self amplified spontaneous emission devices. Yet, in wavelength regimes where a conventional laser seed can be used, the FEL can be used as an amplifier. One promising application is for very high average power generation, for instance a 100 kW average power FEL. The high electron beam power, high brightness and high efficiency that can be achieved with photoinjectors and superconducting energy recovery linacs combine well with the high-gain FEL amplifier to produce unprecedented average power FELs with some advantages. In addition to the general features of the high average power FEL amplifier, we will look at a 100 kW class FEL amplifier is being designed to operate on the 0.5 ampere Energy Recovery Li...
Independence, Odd Girth, and Average Degree
DEFF Research Database (Denmark)
Löwenstein, Christian; Pedersen, Anders Sune; Rautenbach, Dieter;
2011-01-01
We prove several tight lower bounds in terms of the order and the average degree for the independence number of graphs that are connected and/or satisfy some odd girth condition. Our main result is the extension of a lower bound for the independence number of triangle-free graphs of maximum...
Full averaging of fuzzy impulsive differential inclusions
Directory of Open Access Journals (Sweden)
Natalia V. Skripnik
2010-09-01
Full Text Available In this paper the substantiation of the method of full averaging for fuzzy impulsive differential inclusions is studied. We extend the similar results for impulsive differential inclusions with Hukuhara derivative (Skripnik, 2007, for fuzzy impulsive differential equations (Plotnikov and Skripnik, 2009, and for fuzzy differential inclusions (Skripnik, 2009.
Materials for high average power lasers
Energy Technology Data Exchange (ETDEWEB)
Marion, J.E.; Pertica, A.J.
1989-01-01
Unique materials properties requirements for solid state high average power (HAP) lasers dictate a materials development research program. A review of the desirable laser, optical and thermo-mechanical properties for HAP lasers precedes an assessment of the development status for crystalline and glass hosts optimized for HAP lasers. 24 refs., 7 figs., 1 tab.
A dynamic analysis of moving average rules
C. Chiarella; X.Z. He; C.H. Hommes
2006-01-01
The use of various moving average (MA) rules remains popular with financial market practitioners. These rules have recently become the focus of a number empirical studies, but there have been very few studies of financial market models where some agents employ technical trading rules of the type use
Averaged Extended Tree Augmented Naive Classifier
Directory of Open Access Journals (Sweden)
Aaron Meehan
2015-07-01
Full Text Available This work presents a new general purpose classifier named Averaged Extended Tree Augmented Naive Bayes (AETAN, which is based on combining the advantageous characteristics of Extended Tree Augmented Naive Bayes (ETAN and Averaged One-Dependence Estimator (AODE classifiers. We describe the main properties of the approach and algorithms for learning it, along with an analysis of its computational time complexity. Empirical results with numerous data sets indicate that the new approach is superior to ETAN and AODE in terms of both zero-one classification accuracy and log loss. It also compares favourably against weighted AODE and hidden Naive Bayes. The learning phase of the new approach is slower than that of its competitors, while the time complexity for the testing phase is similar. Such characteristics suggest that the new classifier is ideal in scenarios where online learning is not required.
Trajectory averaging for stochastic approximation MCMC algorithms
Liang, Faming
2010-01-01
The subject of stochastic approximation was founded by Robbins and Monro [Ann. Math. Statist. 22 (1951) 400--407]. After five decades of continual development, it has developed into an important area in systems control and optimization, and it has also served as a prototype for the development of adaptive algorithms for on-line estimation and control of stochastic systems. Recently, it has been used in statistics with Markov chain Monte Carlo for solving maximum likelihood estimation problems and for general simulation and optimizations. In this paper, we first show that the trajectory averaging estimator is asymptotically efficient for the stochastic approximation MCMC (SAMCMC) algorithm under mild conditions, and then apply this result to the stochastic approximation Monte Carlo algorithm [Liang, Liu and Carroll J. Amer. Statist. Assoc. 102 (2007) 305--320]. The application of the trajectory averaging estimator to other stochastic approximation MCMC algorithms, for example, a stochastic approximation MLE al...
ANALYSIS OF THE FACTORS AFFECTING THE AVERAGE
Directory of Open Access Journals (Sweden)
Carmen BOGHEAN
2013-12-01
Full Text Available Productivity in agriculture most relevantly and concisely expresses the economic efficiency of using the factors of production. Labour productivity is affected by a considerable number of variables (including the relationship system and interdependence between factors, which differ in each economic sector and influence it, giving rise to a series of technical, economic and organizational idiosyncrasies. The purpose of this paper is to analyse the underlying factors of the average work productivity in agriculture, forestry and fishing. The analysis will take into account the data concerning the economically active population and the gross added value in agriculture, forestry and fishing in Romania during 2008-2011. The distribution of the average work productivity per factors affecting it is conducted by means of the u-substitution method.
Time-average dynamic speckle interferometry
Vladimirov, A. P.
2014-05-01
For the study of microscopic processes occurring at structural level in solids and thin biological objects, a method of dynamic speckle interferometry successfully applied. However, the method has disadvantages. The purpose of the report is to acquaint colleagues with the method of averaging in time in dynamic speckle - interferometry of microscopic processes, allowing eliminating shortcomings. The main idea of the method is the choice the averaging time, which exceeds the characteristic time correlation (relaxation) the most rapid process. The method theory for a thin phase and the reflecting object is given. The results of the experiment on the high-cycle fatigue of steel and experiment to estimate the biological activity of a monolayer of cells, cultivated on a transparent substrate is given. It is shown that the method allows real-time visualize the accumulation of fatigue damages and reliably estimate the activity of cells with viruses and without viruses.
Average Annual Rainfall over the Globe
Agrawal, D. C.
2013-01-01
The atmospheric recycling of water is a very important phenomenon on the globe because it not only refreshes the water but it also redistributes it over land and oceans/rivers/lakes throughout the globe. This is made possible by the solar energy intercepted by the Earth. The half of the globe facing the Sun, on the average, intercepts 1.74 ×…
Endogenous average cost based access pricing
Fjell, Kenneth; Foros, Øystein; Pal, Debashis
2006-01-01
We consider an industry where a downstream competitor requires access to an upstream facility controlled by a vertically integrated and regulated incumbent. The literature on access pricing assumes the access price to be exogenously fixed ex-ante. We analyze an endogenous average cost based access pricing rule, where both firms realize the interdependence among their quantities and the regulated access price. Endogenous access pricing neutralizes the artificial cost advantag...
The Ghirlanda-Guerra identities without averaging
Chatterjee, Sourav
2009-01-01
The Ghirlanda-Guerra identities are one of the most mysterious features of spin glasses. We prove the GG identities in a large class of models that includes the Edwards-Anderson model, the random field Ising model, and the Sherrington-Kirkpatrick model in the presence of a random external field. Previously, the GG identities were rigorously proved only `on average' over a range of temperatures or under small perturbations.
Average Annual Rainfall over the Globe
Agrawal, D. C.
2013-01-01
The atmospheric recycling of water is a very important phenomenon on the globe because it not only refreshes the water but it also redistributes it over land and oceans/rivers/lakes throughout the globe. This is made possible by the solar energy intercepted by the Earth. The half of the globe facing the Sun, on the average, intercepts 1.74 ×…
Average Light Intensity Inside a Photobioreactor
Directory of Open Access Journals (Sweden)
Herby Jean
2011-01-01
Full Text Available For energy production, microalgae are one of the few alternatives with high potential. Similar to plants, algae require energy acquired from light sources to grow. This project uses calculus to determine the light intensity inside of a photobioreactor filled with algae. Under preset conditions along with estimated values, we applied Lambert-Beer's law to formulate an equation to calculate how much light intensity escapes a photobioreactor and determine the average light intensity that was present inside the reactor.
Geomagnetic effects on the average surface temperature
Ballatore, P.
Several results have previously shown as the solar activity can be related to the cloudiness and the surface solar radiation intensity (Svensmark and Friis-Christensen, J. Atmos. Sol. Terr. Phys., 59, 1225, 1997; Veretenenkoand Pudovkin, J. Atmos. Sol. Terr. Phys., 61, 521, 1999). Here, the possible relationships between the averaged surface temperature and the solar wind parameters or geomagnetic activity indices are investigated. The temperature data used are the monthly SST maps (generated at RAL and available from the related ESRIN/ESA database) that represent the averaged surface temperature with a spatial resolution of 0.5°x0.5° and cover the entire globe. The interplanetary data and the geomagnetic data are from the USA National Space Science Data Center. The time interval considered is 1995-2000. Specifically, possible associations and/or correlations of the average temperature with the interplanetary magnetic field Bz component and with the Kp index are considered and differentiated taking into account separate geographic and geomagnetic planetary regions.
Unscrambling The "Average User" Of Habbo Hotel
Directory of Open Access Journals (Sweden)
Mikael Johnson
2007-01-01
Full Text Available The “user” is an ambiguous concept in human-computer interaction and information systems. Analyses of users as social actors, participants, or configured users delineate approaches to studying design-use relationships. Here, a developer’s reference to a figure of speech, termed the “average user,” is contrasted with design guidelines. The aim is to create an understanding about categorization practices in design through a case study about the virtual community, Habbo Hotel. A qualitative analysis highlighted not only the meaning of the “average user,” but also the work that both the developer and the category contribute to this meaning. The average user a represents the unknown, b influences the boundaries of the target user groups, c legitimizes the designer to disregard marginal user feedback, and d keeps the design space open, thus allowing for creativity. The analysis shows how design and use are intertwined and highlights the developers’ role in governing different users’ interests.
On Backus average for generally anisotropic layers
Bos, Len; Slawinski, Michael A; Stanoev, Theodore
2016-01-01
In this paper, following the Backus (1962) approach, we examine expressions for elasticity parameters of a homogeneous generally anisotropic medium that is long-wave-equivalent to a stack of thin generally anisotropic layers. These expressions reduce to the results of Backus (1962) for the case of isotropic and transversely isotropic layers. In over half-a-century since the publications of Backus (1962) there have been numerous publications applying and extending that formulation. However, neither George Backus nor the authors of the present paper are aware of further examinations of mathematical underpinnings of the original formulation; hence, this paper. We prove that---within the long-wave approximation---if the thin layers obey stability conditions then so does the equivalent medium. We examine---within the Backus-average context---the approximation of the average of a product as the product of averages, and express it as a proposition in terms of an upper bound. In the presented examination we use the e...
A simple algorithm for averaging spike trains.
Julienne, Hannah; Houghton, Conor
2013-02-25
Although spike trains are the principal channel of communication between neurons, a single stimulus will elicit different spike trains from trial to trial. This variability, in both spike timings and spike number can obscure the temporal structure of spike trains and often means that computations need to be run on numerous spike trains in order to extract features common across all the responses to a particular stimulus. This can increase the computational burden and obscure analytical results. As a consequence, it is useful to consider how to calculate a central spike train that summarizes a set of trials. Indeed, averaging responses over trials is routine for other signal types. Here, a simple method for finding a central spike train is described. The spike trains are first mapped to functions, these functions are averaged, and a greedy algorithm is then used to map the average function back to a spike train. The central spike trains are tested for a large data set. Their performance on a classification-based test is considerably better than the performance of the medoid spike trains.
Changing mortality and average cohort life expectancy
Directory of Open Access Journals (Sweden)
Robert Schoen
2005-10-01
Full Text Available Period life expectancy varies with changes in mortality, and should not be confused with the life expectancy of those alive during that period. Given past and likely future mortality changes, a recent debate has arisen on the usefulness of the period life expectancy as the leading measure of survivorship. An alternative aggregate measure of period mortality which has been seen as less sensitive to period changes, the cross-sectional average length of life (CAL has been proposed as an alternative, but has received only limited empirical or analytical examination. Here, we introduce a new measure, the average cohort life expectancy (ACLE, to provide a precise measure of the average length of life of cohorts alive at a given time. To compare the performance of ACLE with CAL and with period and cohort life expectancy, we first use population models with changing mortality. Then the four aggregate measures of mortality are calculated for England and Wales, Norway, and Switzerland for the years 1880 to 2000. CAL is found to be sensitive to past and present changes in death rates. ACLE requires the most data, but gives the best representation of the survivorship of cohorts present at a given time.
Disk-averaged synthetic spectra of Mars
Tinetti, Giovanna; Meadows, Victoria S.; Crisp, David; Fong, William; Velusamy, Thangasamy; Snively, Heather
2005-01-01
The principal goal of the NASA Terrestrial Planet Finder (TPF) and European Space Agency's Darwin mission concepts is to directly detect and characterize extrasolar terrestrial (Earthsized) planets. This first generation of instruments is expected to provide disk-averaged spectra with modest spectral resolution and signal-to-noise. Here we use a spatially and spectrally resolved model of a Mars-like planet to study the detectability of a planet's surface and atmospheric properties from disk-averaged spectra. We explore the detectability as a function of spectral resolution and wavelength range, for both the proposed visible coronograph (TPFC) and mid-infrared interferometer (TPF-I/Darwin) architectures. At the core of our model is a spectrum-resolving (line-by-line) atmospheric/surface radiative transfer model. This model uses observational data as input to generate a database of spatially resolved synthetic spectra for a range of illumination conditions and viewing geometries. The model was validated against spectra recorded by the Mars Global Surveyor-Thermal Emission Spectrometer and the Mariner 9-Infrared Interferometer Spectrometer. Results presented here include disk-averaged synthetic spectra, light curves, and the spectral variability at visible and mid-infrared wavelengths for Mars as a function of viewing angle, illumination, and season. We also considered the differences in the spectral appearance of an increasingly ice-covered Mars, as a function of spectral resolution, signal-to-noise and integration time for both TPF-C and TPFI/ Darwin.
Spatial averaging infiltration model for layered soil
Institute of Scientific and Technical Information of China (English)
HU HePing; YANG ZhiYong; TIAN FuQiang
2009-01-01
To quantify the influences of soil heterogeneity on infiltration, a spatial averaging infiltration model for layered soil (SAI model) is developed by coupling the spatial averaging approach proposed by Chen et al. and the Generalized Green-Ampt model proposed by Jia et al. In the SAI model, the spatial heterogeneity along the horizontal direction is described by a probability distribution function, while that along the vertical direction is represented by the layered soils. The SAI model is tested on a typical soil using Monte Carlo simulations as the base model. The results show that the SAI model can directly incorporate the influence of spatial heterogeneity on infiltration on the macro scale. It is also found that the homogeneous assumption of soil hydraulic conductivity along the horizontal direction will overestimate the infiltration rate, while that along the vertical direction will underestimate the infiltration rate significantly during rainstorm periods. The SAI model is adopted in the spatial averaging hydrological model developed by the authors, and the results prove that it can be applied in the macro-scale hydrological and land surface process modeling in a promising way.
Spatial averaging infiltration model for layered soil
Institute of Scientific and Technical Information of China (English)
无
2009-01-01
To quantify the influences of soil heterogeneity on infiltration, a spatial averaging infiltration model for layered soil (SAI model) is developed by coupling the spatial averaging approach proposed by Chen et al. and the Generalized Green-Ampt model proposed by Jia et al. In the SAI model, the spatial hetero- geneity along the horizontal direction is described by a probability distribution function, while that along the vertical direction is represented by the layered soils. The SAI model is tested on a typical soil using Monte Carlo simulations as the base model. The results show that the SAI model can directly incorporate the influence of spatial heterogeneity on infiltration on the macro scale. It is also found that the homogeneous assumption of soil hydraulic conductivity along the horizontal direction will overes- timate the infiltration rate, while that along the vertical direction will underestimate the infiltration rate significantly during rainstorm periods. The SAI model is adopted in the spatial averaging hydrological model developed by the authors, and the results prove that it can be applied in the macro-scale hy- drological and land surface process modeling in a promising way.
Disk-averaged synthetic spectra of Mars
Tinetti, G; Fong, W; Meadows, V S; Snively, H; Velusamy, T; Crisp, David; Fong, William; Meadows, Victoria S.; Snively, Heather; Tinetti, Giovanna; Velusamy, Thangasamy
2004-01-01
The principal goal of the NASA Terrestrial Planet Finder (TPF) and ESA Darwin mission concepts is to directly detect and characterize extrasolar terrestrial (Earth-sized) planets. This first generation of instruments is expected to provide disk-averaged spectra with modest spectral resolution and signal-to-noise. Here we use a spatially and spectrally resolved model of the planet Mars to study the detectability of a planet's surface and atmospheric properties from disk-averaged spectra as a function of spectral resolution and wavelength range, for both the proposed visible coronograph (TPF-C) and mid-infrared interferometer (TPF-I/Darwin) architectures. At the core of our model is a spectrum-resolving (line-by-line) atmospheric/surface radiative transfer model which uses observational data as input to generate a database of spatially-resolved synthetic spectra for a range of illumination conditions (phase angles) and viewing geometries. Results presented here include disk averaged synthetic spectra, light-cur...
Disk-averaged synthetic spectra of Mars
Tinetti, Giovanna; Meadows, Victoria S.; Crisp, David; Fong, William; Velusamy, Thangasamy; Snively, Heather
2005-01-01
The principal goal of the NASA Terrestrial Planet Finder (TPF) and European Space Agency's Darwin mission concepts is to directly detect and characterize extrasolar terrestrial (Earthsized) planets. This first generation of instruments is expected to provide disk-averaged spectra with modest spectral resolution and signal-to-noise. Here we use a spatially and spectrally resolved model of a Mars-like planet to study the detectability of a planet's surface and atmospheric properties from disk-averaged spectra. We explore the detectability as a function of spectral resolution and wavelength range, for both the proposed visible coronograph (TPFC) and mid-infrared interferometer (TPF-I/Darwin) architectures. At the core of our model is a spectrum-resolving (line-by-line) atmospheric/surface radiative transfer model. This model uses observational data as input to generate a database of spatially resolved synthetic spectra for a range of illumination conditions and viewing geometries. The model was validated against spectra recorded by the Mars Global Surveyor-Thermal Emission Spectrometer and the Mariner 9-Infrared Interferometer Spectrometer. Results presented here include disk-averaged synthetic spectra, light curves, and the spectral variability at visible and mid-infrared wavelengths for Mars as a function of viewing angle, illumination, and season. We also considered the differences in the spectral appearance of an increasingly ice-covered Mars, as a function of spectral resolution, signal-to-noise and integration time for both TPF-C and TPFI/ Darwin.
Exponential reduction of finite volume effects with twisted boundary conditions
Cherman, Aleksey; Wagman, Michael L; Yaffe, Laurence G
2016-01-01
Flavor-twisted boundary conditions can be used for exponential reduction of finite volume artifacts in flavor-averaged observables in lattice QCD calculations with $SU(N_f)$ light quark flavor symmetry. Finite volume artifact reduction arises from destructive interference effects in a manner closely related to the phase averaging which leads to large $N_c$ volume independence. With a particular choice of flavor-twisted boundary conditions, finite volume artifacts for flavor-singlet observables in a hypercubic spacetime volume are reduced to the size of finite volume artifacts in a spacetime volume with periodic boundary conditions that is four times larger.
Anastas, Robert, Comp.; And Others.
GRADES OR AGES: Secondary grades. SUBJECT MATTER: Drugs and drug abuse. ORGANIZATION AND PHYSICAL APPEARANCE: The guide is divided into several sections, each of which is in outline or list form. It is xeroxed and spiral-bound with a paper cover. OBJECTIVES AND ACTIVITIES: No objectives are mentioned. The major portion of the guide contains a…
Allergic reaction - drug (medication); Drug hypersensitivity; Medication hypersensitivity ... A drug allergy involves an immune response in the body that produces an allergic reaction to a medicine. The ...
Gover, A. Rod; Waldron, Andrew
2017-09-01
We develop a universal distributional calculus for regulated volumes of metrics that are suitably singular along hypersurfaces. When the hypersurface is a conformal infinity we give simple integrated distribution expressions for the divergences and anomaly of the regulated volume functional valid for any choice of regulator. For closed hypersurfaces or conformally compact geometries, methods from a previously developed boundary calculus for conformally compact manifolds can be applied to give explicit holographic formulæ for the divergences and anomaly expressed as hypersurface integrals over local quantities (the method also extends to non-closed hypersurfaces). The resulting anomaly does not depend on any particular choice of regulator, while the regulator dependence of the divergences is precisely captured by these formulæ. Conformal hypersurface invariants can be studied by demanding that the singular metric obey, smoothly and formally to a suitable order, a Yamabe type problem with boundary data along the conformal infinity. We prove that the volume anomaly for these singular Yamabe solutions is a conformally invariant integral of a local Q-curvature that generalizes the Branson Q-curvature by including data of the embedding. In each dimension this canonically defines a higher dimensional generalization of the Willmore energy/rigid string action. Recently, Graham proved that the first variation of the volume anomaly recovers the density obstructing smooth solutions to this singular Yamabe problem; we give a new proof of this result employing our boundary calculus. Physical applications of our results include studies of quantum corrections to entanglement entropies.
Lifescience Database Archive (English)
Full Text Available ood Products/Modifiers/Volume Expanders Anticoagulants Warfarin D01280 Warfarin potassium (JP16) Target-base...Warfarin D01280 Warfarin potassium (JP16) USP drug classification [BR:br08302] Bl
Lifescience Database Archive (English)
Full Text Available D02796 Drug Albumin iodinated I 131 serum (USAN); Megatope (TN) Diagnostic aid [blo...od volume determination]; Diagnostic aid [intrathecal imaging]; Radioactive agent ATC code: V09XA03 Anatomic
Lifescience Database Archive (English)
Full Text Available D02795 Drug Iodinated I 131 albumin (USP); Albumin iodinated I 131 Diagnostic aid [...blood volume determination]; Diagnostic aid [intrathecal imaging]; Radioactive agent PubChem: 17396953 ...
Lifescience Database Archive (English)
Full Text Available Volume Expanders Blood Formation Modifiers Plerixafor D08971 Plerixafor (USAN/INN...3AX16 Plerixafor D08971 Plerixafor (USAN/INN) USP drug classification [BR:br08302] Blood Products/Modifiers/
De Luca, G.; Magnus, J.R.
2011-01-01
This article is concerned with the estimation of linear regression models with uncertainty about the choice of the explanatory variables. We introduce the Stata commands bma and wals which implement, respectively, the exact Bayesian Model Averaging (BMA) estimator and the Weighted Average Least Squa
Illicit Drugs and Insurgency in Afghanistan
Directory of Open Access Journals (Sweden)
Ekaterina Stepanova
2012-05-01
Full Text Available It is argued that the relationship between illicit drugs and the insurgency in Afghanistan cannot be captured by the simplistic concept of “narco-terrorism”. Rather, it has to be seen in terms of linkages of various types and degrees between two distinct phenomena. Drug trafficking may generate criminal violence in both peacetime and conflict settings. In the latter case, the illicit drug business becomes a “conflict resource”, while also serving shadow economic functions (such as serving as a social-economic coping strategy to peasants in some areas and generating organized criminal violence and street delinquency. Organized crime groups play the main role in the illicit drug business, especially at the higher, internationalized levels of the drug chain. Drug profits are in fact lowest in the drug producing areas themselves. In the case of Afghanistan, only 4.3 per cent (or US $ 2,9 billion of the US $ 60 billion average annual volume of the global market for Afghan opiates remain in the country. Of the proceeds that stay in Afghanistan, the author estimates that no more than between US $ 100-150 million probably went to the Taliban in 2011. The US/NATO war on the Taliban has not significantly reduced Afghanistan’s opium economy. The prospects for achieving significant results in counter-narcotics after the US/NATO withdrawal in 2014 are dim unless major armed conflict comes to an end – a goal likely to be achieved only if Afghanistan is decentralized and regionalized and the Taliban is given a regional role in Pashtu parts of the country whereby tougher counter-narcotics provisions should be a negotiable demand/condition for any configuration of talks with the insurgents on the political settlement.
A sixth order averaged vector field method
Li, Haochen; Wang, Yushun; Qin, Mengzhao
2014-01-01
In this paper, based on the theory of rooted trees and B-series, we propose the concrete formulas of the substitution law for the trees of order =5. With the help of the new substitution law, we derive a B-series integrator extending the averaged vector field (AVF) method to high order. The new integrator turns out to be of order six and exactly preserves energy for Hamiltonian systems. Numerical experiments are presented to demonstrate the accuracy and the energy-preserving property of the s...
Phase-averaged transport for quasiperiodic Hamiltonians
Bellissard, J; Schulz-Baldes, H
2002-01-01
For a class of discrete quasi-periodic Schroedinger operators defined by covariant re- presentations of the rotation algebra, a lower bound on phase-averaged transport in terms of the multifractal dimensions of the density of states is proven. This result is established under a Diophantine condition on the incommensuration parameter. The relevant class of operators is distinguished by invariance with respect to symmetry automorphisms of the rotation algebra. It includes the critical Harper (almost-Mathieu) operator. As a by-product, a new solution of the frame problem associated with Weyl-Heisenberg-Gabor lattices of coherent states is given.
Sparsity averaging for radio-interferometric imaging
Carrillo, Rafael E; Wiaux, Yves
2014-01-01
We propose a novel regularization method for compressive imaging in the context of the compressed sensing (CS) theory with coherent and redundant dictionaries. Natural images are often complicated and several types of structures can be present at once. It is well known that piecewise smooth images exhibit gradient sparsity, and that images with extended structures are better encapsulated in wavelet frames. Therefore, we here conjecture that promoting average sparsity or compressibility over multiple frames rather than single frames is an extremely powerful regularization prior.
Fluctuations of wavefunctions about their classical average
Energy Technology Data Exchange (ETDEWEB)
Benet, L [Centro Internacional de Ciencias, Ciudad Universitaria, Chamilpa, Cuernavaca (Mexico); Flores, J [Centro Internacional de Ciencias, Ciudad Universitaria, Chamilpa, Cuernavaca (Mexico); Hernandez-Saldana, H [Centro Internacional de Ciencias, Ciudad Universitaria, Chamilpa, Cuernavaca (Mexico); Izrailev, F M [Centro Internacional de Ciencias, Ciudad Universitaria, Chamilpa, Cuernavaca (Mexico); Leyvraz, F [Centro Internacional de Ciencias, Ciudad Universitaria, Chamilpa, Cuernavaca (Mexico); Seligman, T H [Centro Internacional de Ciencias, Ciudad Universitaria, Chamilpa, Cuernavaca (Mexico)
2003-02-07
Quantum-classical correspondence for the average shape of eigenfunctions and the local spectral density of states are well-known facts. In this paper, the fluctuations of the quantum wavefunctions around the classical value are discussed. A simple random matrix model leads to a Gaussian distribution of the amplitudes whose width is determined by the classical shape of the eigenfunction. To compare this prediction with numerical calculations in chaotic models of coupled quartic oscillators, we develop a rescaling method for the components. The expectations are broadly confirmed, but deviations due to scars are observed. This effect is much reduced when both Hamiltonians have chaotic dynamics.
Fluctuations of wavefunctions about their classical average
Bénet, L; Hernandez-Saldana, H; Izrailev, F M; Leyvraz, F; Seligman, T H
2003-01-01
Quantum-classical correspondence for the average shape of eigenfunctions and the local spectral density of states are well-known facts. In this paper, the fluctuations of the quantum wavefunctions around the classical value are discussed. A simple random matrix model leads to a Gaussian distribution of the amplitudes whose width is determined by the classical shape of the eigenfunction. To compare this prediction with numerical calculations in chaotic models of coupled quartic oscillators, we develop a rescaling method for the components. The expectations are broadly confirmed, but deviations due to scars are observed. This effect is much reduced when both Hamiltonians have chaotic dynamics.
Grassmann Averages for Scalable Robust PCA
2014-01-01
As the collection of large datasets becomes increasingly automated, the occurrence of outliers will increase—“big data” implies “big outliers”. While principal component analysis (PCA) is often used to reduce the size of data, and scalable solutions exist, it is well-known that outliers can arbitrarily corrupt the results. Unfortunately, state-of-the-art approaches for robust PCA do not scale beyond small-to-medium sized datasets. To address this, we introduce the Grassmann Average (GA), whic...
Source of non-arrhenius average relaxation time in glass-forming liquids
DEFF Research Database (Denmark)
Dyre, Jeppe
1998-01-01
A major mystery of glass-forming liquids is the non-Arrhenius temperature-dependence of the average relaxation time. This paper briefly reviews the classical phenomenological models for non-Arrhenius behavior the free volume model and the entropy model and critiques against these models. We...... are anharmonic, the non-Arrhenius temperature-dependence of the average relaxation time is a consequence of the fact that the instantaneous shear modulus increases upon cooling....
Detrending moving average algorithm for multifractals
Gu, Gao-Feng; Zhou, Wei-Xing
2010-07-01
The detrending moving average (DMA) algorithm is a widely used technique to quantify the long-term correlations of nonstationary time series and the long-range correlations of fractal surfaces, which contains a parameter θ determining the position of the detrending window. We develop multifractal detrending moving average (MFDMA) algorithms for the analysis of one-dimensional multifractal measures and higher-dimensional multifractals, which is a generalization of the DMA method. The performance of the one-dimensional and two-dimensional MFDMA methods is investigated using synthetic multifractal measures with analytical solutions for backward (θ=0) , centered (θ=0.5) , and forward (θ=1) detrending windows. We find that the estimated multifractal scaling exponent τ(q) and the singularity spectrum f(α) are in good agreement with the theoretical values. In addition, the backward MFDMA method has the best performance, which provides the most accurate estimates of the scaling exponents with lowest error bars, while the centered MFDMA method has the worse performance. It is found that the backward MFDMA algorithm also outperforms the multifractal detrended fluctuation analysis. The one-dimensional backward MFDMA method is applied to analyzing the time series of Shanghai Stock Exchange Composite Index and its multifractal nature is confirmed.
Trajectory averaging for stochastic approximation MCMC algorithms
Liang, Faming
2010-10-01
The subject of stochastic approximation was founded by Robbins and Monro [Ann. Math. Statist. 22 (1951) 400-407]. After five decades of continual development, it has developed into an important area in systems control and optimization, and it has also served as a prototype for the development of adaptive algorithms for on-line estimation and control of stochastic systems. Recently, it has been used in statistics with Markov chain Monte Carlo for solving maximum likelihood estimation problems and for general simulation and optimizations. In this paper, we first show that the trajectory averaging estimator is asymptotically efficient for the stochastic approximation MCMC (SAMCMC) algorithm under mild conditions, and then apply this result to the stochastic approximation Monte Carlo algorithm [Liang, Liu and Carroll J. Amer. Statist. Assoc. 102 (2007) 305-320]. The application of the trajectory averaging estimator to other stochastic approximationMCMC algorithms, for example, a stochastic approximation MLE algorithm for missing data problems, is also considered in the paper. © Institute of Mathematical Statistics, 2010.
Averaged null energy condition from causality
Hartman, Thomas; Kundu, Sandipan; Tajdini, Amirhossein
2017-07-01
Unitary, Lorentz-invariant quantum field theories in flat spacetime obey mi-crocausality: commutators vanish at spacelike separation. For interacting theories in more than two dimensions, we show that this implies that the averaged null energy, ∫ duT uu , must be non-negative. This non-local operator appears in the operator product expansion of local operators in the lightcone limit, and therefore contributes to n-point functions. We derive a sum rule that isolates this contribution and is manifestly positive. The argument also applies to certain higher spin operators other than the stress tensor, generating an infinite family of new constraints of the form ∫ duX uuu··· u ≥ 0. These lead to new inequalities for the coupling constants of spinning operators in conformal field theory, which include as special cases (but are generally stronger than) the existing constraints from the lightcone bootstrap, deep inelastic scattering, conformal collider methods, and relative entropy. We also comment on the relation to the recent derivation of the averaged null energy condition from relative entropy, and suggest a more general connection between causality and information-theoretic inequalities in QFT.
MACHINE PROTECTION FOR HIGH AVERAGE CURRENT LINACS
Energy Technology Data Exchange (ETDEWEB)
Jordan, Kevin; Allison, Trent; Evans, Richard; Coleman, James; Grippo, Albert
2003-05-01
A fully integrated Machine Protection System (MPS) is critical to efficient commissioning and safe operation of all high current accelerators. The Jefferson Lab FEL [1,2] has multiple electron beam paths and many different types of diagnostic insertion devices. The MPS [3] needs to monitor both the status of these devices and the magnet settings which define the beam path. The matrix of these devices and beam paths are programmed into gate arrays, the output of the matrix is an allowable maximum average power limit. This power limit is enforced by the drive laser for the photocathode gun. The Beam Loss Monitors (BLMs), RF status, and laser safety system status are also inputs to the control matrix. There are 8 Machine Modes (electron path) and 8 Beam Modes (average power limits) that define the safe operating limits for the FEL. Combinations outside of this matrix are unsafe and the beam is inhibited. The power limits range from no beam to 2 megawatts of electron beam power.
Intensity contrast of the average supergranule
Langfellner, J; Gizon, L
2016-01-01
While the velocity fluctuations of supergranulation dominate the spectrum of solar convection at the solar surface, very little is known about the fluctuations in other physical quantities like temperature or density at supergranulation scale. Using SDO/HMI observations, we characterize the intensity contrast of solar supergranulation at the solar surface. We identify the positions of ${\\sim}10^4$ outflow and inflow regions at supergranulation scales, from which we construct average flow maps and co-aligned intensity and magnetic field maps. In the average outflow center, the maximum intensity contrast is $(7.8\\pm0.6)\\times10^{-4}$ (there is no corresponding feature in the line-of-sight magnetic field). This corresponds to a temperature perturbation of about $1.1\\pm0.1$ K, in agreement with previous studies. We discover an east-west anisotropy, with a slightly deeper intensity minimum east of the outflow center. The evolution is asymmetric in time: the intensity excess is larger 8 hours before the reference t...
Local average height distribution of fluctuating interfaces
Smith, Naftali R.; Meerson, Baruch; Sasorov, Pavel V.
2017-01-01
Height fluctuations of growing surfaces can be characterized by the probability distribution of height in a spatial point at a finite time. Recently there has been spectacular progress in the studies of this quantity for the Kardar-Parisi-Zhang (KPZ) equation in 1 +1 dimensions. Here we notice that, at or above a critical dimension, the finite-time one-point height distribution is ill defined in a broad class of linear surface growth models unless the model is regularized at small scales. The regularization via a system-dependent small-scale cutoff leads to a partial loss of universality. As a possible alternative, we introduce a local average height. For the linear models, the probability density of this quantity is well defined in any dimension. The weak-noise theory for these models yields the "optimal path" of the interface conditioned on a nonequilibrium fluctuation of the local average height. As an illustration, we consider the conserved Edwards-Wilkinson (EW) equation, where, without regularization, the finite-time one-point height distribution is ill defined in all physical dimensions. We also determine the optimal path of the interface in a closely related problem of the finite-time height-difference distribution for the nonconserved EW equation in 1 +1 dimension. Finally, we discuss a UV catastrophe in the finite-time one-point distribution of height in the (nonregularized) KPZ equation in 2 +1 dimensions.
Asymptotic Time Averages and Frequency Distributions
Directory of Open Access Journals (Sweden)
Muhammad El-Taha
2016-01-01
Full Text Available Consider an arbitrary nonnegative deterministic process (in a stochastic setting {X(t, t≥0} is a fixed realization, i.e., sample-path of the underlying stochastic process with state space S=(-∞,∞. Using a sample-path approach, we give necessary and sufficient conditions for the long-run time average of a measurable function of process to be equal to the expectation taken with respect to the same measurable function of its long-run frequency distribution. The results are further extended to allow unrestricted parameter (time space. Examples are provided to show that our condition is not superfluous and that it is weaker than uniform integrability. The case of discrete-time processes is also considered. The relationship to previously known sufficient conditions, usually given in stochastic settings, will also be discussed. Our approach is applied to regenerative processes and an extension of a well-known result is given. For researchers interested in sample-path analysis, our results will give them the choice to work with the time average of a process or its frequency distribution function and go back and forth between the two under a mild condition.
Full Text Available ... Use and Unborn Children Drug Use and Your Health Other Effects on the Body Drug Use Hurts Brains Drug Use and Mental Health Problems Often Happen Together The Link Between Drug ...
... uses. Other uses of these drugs are abuse. Club drugs are also sometimes used as "date rape" drugs, to make someone unable to say no to or fight back against sexual assault. Abusing these drugs can ...
Full Text Available ... Nicotine Facts Other Drugs of Abuse What is Addiction? Do You or a Loved One Have a Drug Use Problem? Signs of Drug Use and Addiction How Does Drug Use Become Addiction? Addiction Risk ...
Full Text Available ... Drug Use and Your Health Other Effects on the Body Drug Use Hurts Brains Drug Use and Mental Health Problems Often Happen Together The Link Between Drug Use and HIV/AIDS Treatment & ...
Office of National Drug Control Policy, Washington, DC.
Two approaches were used to estimate the amount of illicit drugs consumed and available for consumption in the United States. Estimates of the number of drug users were multiplied by estimates of the average amount of drugs consumed. Then the supply of drugs available for consumption was examined by estimating the amount of drugs that enters the…
Asymmetric network connectivity using weighted harmonic averages
Morrison, Greg; Mahadevan, L.
2011-02-01
We propose a non-metric measure of the "closeness" felt between two nodes in an undirected, weighted graph using a simple weighted harmonic average of connectivity, that is a real-valued Generalized Erdös Number (GEN). While our measure is developed with a collaborative network in mind, the approach can be of use in a variety of artificial and real-world networks. We are able to distinguish between network topologies that standard distance metrics view as identical, and use our measure to study some simple analytically tractable networks. We show how this might be used to look at asymmetry in authorship networks such as those that inspired the integer Erdös numbers in mathematical coauthorships. We also show the utility of our approach to devise a ratings scheme that we apply to the data from the NetFlix prize, and find a significant improvement using our method over a baseline.
Averaged Null Energy Condition from Causality
Hartman, Thomas; Tajdini, Amirhossein
2016-01-01
Unitary, Lorentz-invariant quantum field theories in flat spacetime obey microcausality: commutators vanish at spacelike separation. For interacting theories in more than two dimensions, we show that this implies that the averaged null energy, $\\int du T_{uu}$, must be positive. This non-local operator appears in the operator product expansion of local operators in the lightcone limit, and therefore contributes to $n$-point functions. We derive a sum rule that isolates this contribution and is manifestly positive. The argument also applies to certain higher spin operators other than the stress tensor, generating an infinite family of new constraints of the form $\\int du X_{uuu\\cdots u} \\geq 0$. These lead to new inequalities for the coupling constants of spinning operators in conformal field theory, which include as special cases (but are generally stronger than) the existing constraints from the lightcone bootstrap, deep inelastic scattering, conformal collider methods, and relative entropy. We also comment ...
Average Gait Differential Image Based Human Recognition
Directory of Open Access Journals (Sweden)
Jinyan Chen
2014-01-01
Full Text Available The difference between adjacent frames of human walking contains useful information for human gait identification. Based on the previous idea a silhouettes difference based human gait recognition method named as average gait differential image (AGDI is proposed in this paper. The AGDI is generated by the accumulation of the silhouettes difference between adjacent frames. The advantage of this method lies in that as a feature image it can preserve both the kinetic and static information of walking. Comparing to gait energy image (GEI, AGDI is more fit to representation the variation of silhouettes during walking. Two-dimensional principal component analysis (2DPCA is used to extract features from the AGDI. Experiments on CASIA dataset show that AGDI has better identification and verification performance than GEI. Comparing to PCA, 2DPCA is a more efficient and less memory storage consumption feature extraction method in gait based recognition.
Geographic Gossip: Efficient Averaging for Sensor Networks
Dimakis, Alexandros G; Wainwright, Martin J
2007-01-01
Gossip algorithms for distributed computation are attractive due to their simplicity, distributed nature, and robustness in noisy and uncertain environments. However, using standard gossip algorithms can lead to a significant waste in energy by repeatedly recirculating redundant information. For realistic sensor network model topologies like grids and random geometric graphs, the inefficiency of gossip schemes is related to the slow mixing times of random walks on the communication graph. We propose and analyze an alternative gossiping scheme that exploits geographic information. By utilizing geographic routing combined with a simple resampling method, we demonstrate substantial gains over previously proposed gossip protocols. For regular graphs such as the ring or grid, our algorithm improves standard gossip by factors of $n$ and $\\sqrt{n}$ respectively. For the more challenging case of random geometric graphs, our algorithm computes the true average to accuracy $\\epsilon$ using $O(\\frac{n^{1.5}}{\\sqrt{\\log ...
Bivariate phase-rectified signal averaging
Schumann, Aicko Y; Bauer, Axel; Schmidt, Georg
2008-01-01
Phase-Rectified Signal Averaging (PRSA) was shown to be a powerful tool for the study of quasi-periodic oscillations and nonlinear effects in non-stationary signals. Here we present a bivariate PRSA technique for the study of the inter-relationship between two simultaneous data recordings. Its performance is compared with traditional cross-correlation analysis, which, however, does not work well for non-stationary data and cannot distinguish the coupling directions in complex nonlinear situations. We show that bivariate PRSA allows the analysis of events in one signal at times where the other signal is in a certain phase or state; it is stable in the presence of noise and impassible to non-stationarities.
Compositional dependences of average positron lifetime in binary As-S/Se glasses
Energy Technology Data Exchange (ETDEWEB)
Ingram, A. [Department of Physics of Opole University of Technology, 75 Ozimska str., Opole, PL-45370 (Poland); Golovchak, R., E-mail: roman_ya@yahoo.com [Department of Materials Science and Engineering, Lehigh University, 5 East Packer Avenue, Bethlehem, PA 18015-3195 (United States); Kostrzewa, M.; Wacke, S. [Department of Physics of Opole University of Technology, 75 Ozimska str., Opole, PL-45370 (Poland); Shpotyuk, M. [Lviv Polytechnic National University, 12, Bandery str., Lviv, UA-79013 (Ukraine); Shpotyuk, O. [Institute of Physics of Jan Dlugosz University, 13/15al. Armii Krajowej, Czestochowa, PL-42201 (Poland)
2012-02-15
Compositional dependence of average positron lifetime is studied systematically in typical representatives of binary As-S and As-Se glasses. This dependence is shown to be in opposite with molar volume evolution. The origin of this anomaly is discussed in terms of bond free solid angle concept applied to different types of structurally-intrinsic nanovoids in a glass.
Spatial averaging-effects on turbulence measured by a continuous-wave coherent lidar
DEFF Research Database (Denmark)
Sjöholm, Mikael; Mikkelsen, Torben; Mann, Jakob;
2009-01-01
The influence of spatial volume averaging of a focused continuous-wave coherent Doppler lidar on observed wind turbulence in the atmospheric surface layer is described and analysed. For the first time, comparisons of lidar-measured turbulent spectra with spectra simultaneously obtained from a mast...
Actuator disk model of wind farms based on the rotor average wind speed
DEFF Research Database (Denmark)
Han, Xing Xing; Xu, Chang; Liu, De You;
2016-01-01
Due to difficulty of estimating the reference wind speed for wake modeling in wind farm, this paper proposes a new method to calculate the momentum source based on the rotor average wind speed. The proposed model applies volume correction factor to reduce the influence of the mesh recognition...
The defined daily dose as a measure of drug consumption in South ...
African Journals Online (AJOL)
drugs. The traditional measures, viz. cost and volume studies, have inherent shortcomings when drug consumption ... drug utilisation in South Africa The DDD methodology has ..... Drug Utilization in Norway during the 1970s -Increases.
Lifescience Database Archive (English)
Full Text Available odium chromate (51Cr) (INN); Rachromate (TN) CrO4. 2Na 160.904 161.9732 D05252.gif Diagnostic aid [blood volume determination]; Radio...br08301] 4 Agents affecting cellular function 43 Radioactive drugs 430 Radioactive drugs 4300 Radio
Intravenous drug delivery in neonates: lessons learnt.
Sherwin, Catherine M T; Medlicott, Natalie J; Reith, David M; Broadbent, Roland S
2014-06-01
Intravenous drug administration presents a series of challenges that relate to the pathophysiology of the neonate and intravenous infusion systems in neonates. These challenges arise from slow intravenous flow rates, small drug volume, dead space volume and limitations on the flush volume in neonates. While there is a reasonable understanding of newborn pharmacokinetics, an appreciation of the substantial delay and variability in the rate of drug delivery from the intravenous line is often lacking. This can lead to difficulties in accurately determining the pharmacokinetic and pharmacodynamic relationship of drugs in the smallest patients. The physical variables that affect the passage of drugs through neonatal lines need to be further explored in order to improve our understanding of their impact on the delivery of drugs by this route in neonates. Through careful investigation, the underlying causes of delayed drug delivery may be identified and administration protocols can then be modified to ensure predictable, appropriate drug input kinetics.
Industrial Applications of High Average Power FELS
Shinn, Michelle D
2005-01-01
The use of lasers for material processing continues to expand, and the annual sales of such lasers exceeds $1 B (US). Large scale (many m2) processing of materials require the economical production of laser powers of the tens of kilowatts, and therefore are not yet commercial processes, although they have been demonstrated. The development of FELs based on superconducting RF (SRF) linac technology provides a scaleable path to laser outputs above 50 kW in the IR, rendering these applications economically viable, since the cost/photon drops as the output power increases. This approach also enables high average power ~ 1 kW output in the UV spectrum. Such FELs will provide quasi-cw (PRFs in the tens of MHz), of ultrafast (pulsewidth ~ 1 ps) output with very high beam quality. This talk will provide an overview of applications tests by our facility's users such as pulsed laser deposition, laser ablation, and laser surface modification, as well as present plans that will be tested with our upgraded FELs. These upg...
A new approach for Bayesian model averaging
Institute of Scientific and Technical Information of China (English)
TIAN XiangJun; XIE ZhengHui; WANG AiHui; YANG XiaoChun
2012-01-01
Bayesian model averaging (BMA) is a recently proposed statistical method for calibrating forecast ensembles from numerical weather models.However,successful implementation of BMA requires accurate estimates of the weights and variances of the individual competing models in the ensemble.Two methods,namely the Expectation-Maximization (EM) and the Markov Chain Monte Carlo (MCMC) algorithms,are widely used for BMA model training.Both methods have their own respective strengths and weaknesses.In this paper,we first modify the BMA log-likelihood function with the aim of removing the additional limitation that requires that the BMA weights add to one,and then use a limited memory quasi-Newtonian algorithm for solving the nonlinear optimization problem,thereby formulating a new approach for BMA (referred to as BMA-BFGS).Several groups of multi-model soil moisture simulation experiments from three land surface models show that the performance of BMA-BFGS is similar to the MCMC method in terms of simulation accuracy,and that both are superior to the EM algorithm.On the other hand,the computational cost of the BMA-BFGS algorithm is substantially less than for MCMC and is almost equivalent to that for EM.
Calculating Free Energies Using Average Force
Darve, Eric; Pohorille, Andrew; DeVincenzi, Donald L. (Technical Monitor)
2001-01-01
A new, general formula that connects the derivatives of the free energy along the selected, generalized coordinates of the system with the instantaneous force acting on these coordinates is derived. The instantaneous force is defined as the force acting on the coordinate of interest so that when it is subtracted from the equations of motion the acceleration along this coordinate is zero. The formula applies to simulations in which the selected coordinates are either unconstrained or constrained to fixed values. It is shown that in the latter case the formula reduces to the expression previously derived by den Otter and Briels. If simulations are carried out without constraining the coordinates of interest, the formula leads to a new method for calculating the free energy changes along these coordinates. This method is tested in two examples - rotation around the C-C bond of 1,2-dichloroethane immersed in water and transfer of fluoromethane across the water-hexane interface. The calculated free energies are compared with those obtained by two commonly used methods. One of them relies on determining the probability density function of finding the system at different values of the selected coordinate and the other requires calculating the average force at discrete locations along this coordinate in a series of constrained simulations. The free energies calculated by these three methods are in excellent agreement. The relative advantages of each method are discussed.
Drug Facts Chat Day: NIH Experts Answer Students' Drug Questions
... average person can live if they smoke cigarettes? Ivan Montoya: The lifetime of a person depends on ... questions and answers is available on the NIDA Web site at Drug and Alcohol Chat Day . Fall ...
Interpreting Sky-Averaged 21-cm Measurements
Mirocha, Jordan
2015-01-01
Within the first ~billion years after the Big Bang, the intergalactic medium (IGM) underwent a remarkable transformation, from a uniform sea of cold neutral hydrogen gas to a fully ionized, metal-enriched plasma. Three milestones during this epoch of reionization -- the emergence of the first stars, black holes (BHs), and full-fledged galaxies -- are expected to manifest themselves as extrema in sky-averaged ("global") measurements of the redshifted 21-cm background. However, interpreting these measurements will be complicated by the presence of strong foregrounds and non-trivialities in the radiative transfer (RT) modeling required to make robust predictions.I have developed numerical models that efficiently solve the frequency-dependent radiative transfer equation, which has led to two advances in studies of the global 21-cm signal. First, frequency-dependent solutions facilitate studies of how the global 21-cm signal may be used to constrain the detailed spectral properties of the first stars, BHs, and galaxies, rather than just the timing of their formation. And second, the speed of these calculations allows one to search vast expanses of a currently unconstrained parameter space, while simultaneously characterizing the degeneracies between parameters of interest. I find principally that (1) physical properties of the IGM, such as its temperature and ionization state, can be constrained robustly from observations of the global 21-cm signal without invoking models for the astrophysical sources themselves, (2) translating IGM properties to galaxy properties is challenging, in large part due to frequency-dependent effects. For instance, evolution in the characteristic spectrum of accreting BHs can modify the 21-cm absorption signal at levels accessible to first generation instruments, but could easily be confused with evolution in the X-ray luminosity star-formation rate relation. Finally, (3) the independent constraints most likely to aide in the interpretation
Medicaid NADAC Pharmacy Drug Pricinig
U.S. Department of Health & Human Services — National Average Drug Acquisition Cost (NADAC) - Below are the NADAC weekly files and the weekly comparison files. Please note that the NADAC file is updated on a...
Full Text Available ... and Nicotine Facts Other Drugs of Abuse What is Addiction? What are some signs and symptoms of ... to Drugs? Does Addiction Run in Families? Why Is It So Hard to Quit Drugs? Effects of ...
... problem is interactions, which may occur between Two drugs, such as aspirin and blood thinners Drugs and food, such as statins and grapefruit Drugs and supplements, such as ginkgo and blood thinners ...
HIV Treatment Drug Resistance (Last updated 3/2/2017; last reviewed 3/2/2017) Key Points As HIV multiplies in the ... the risk of drug resistance. What is HIV drug resistance? Once a person becomes infected with HIV, ...
Gover, A Rod
2016-01-01
For any conformally compact manifold with hypersurface boundary we define a canonical renormalized volume functional and compute an explicit, holographic formula for the corresponding anomaly. For the special case of asymptotically Einstein manifolds, our method recovers the known results. The anomaly does not depend on any particular choice of regulator, but the coefficients of divergences do. We give explicit formulae for these divergences valid for any choice of regulating hypersurface; these should be relevant to recent studies of quantum corrections to entanglement entropies. The anomaly is expressed as a conformally invariant integral of a local Q-curvature that generalizes the Branson Q-curvature by including data of the embedding. In each dimension this canonically defines a higher dimensional generalization of the Willmore energy/rigid string action. We show that the variation of these energy functionals is exactly the obstruction to solving a singular Yamabe type problem with boundary data along the...
DEFF Research Database (Denmark)
Pedersen, Sune; Galatius, Soren; Mogelvang, Rasmus
2011-01-01
Use of drug-eluting stents (DES) in patients with ST-elevation myocardial infarction (STEMI) during routine primary percutaneous coronary intervention (pPCI) is controversial.......Use of drug-eluting stents (DES) in patients with ST-elevation myocardial infarction (STEMI) during routine primary percutaneous coronary intervention (pPCI) is controversial....
Potential of high-average-power solid state lasers
Energy Technology Data Exchange (ETDEWEB)
Emmett, J.L.; Krupke, W.F.; Sooy, W.R.
1984-09-25
We discuss the possibility of extending solid state laser technology to high average power and of improving the efficiency of such lasers sufficiently to make them reasonable candidates for a number of demanding applications. A variety of new design concepts, materials, and techniques have emerged over the past decade that, collectively, suggest that the traditional technical limitations on power (a few hundred watts or less) and efficiency (less than 1%) can be removed. The core idea is configuring the laser medium in relatively thin, large-area plates, rather than using the traditional low-aspect-ratio rods or blocks. This presents a large surface area for cooling, and assures that deposited heat is relatively close to a cooled surface. It also minimizes the laser volume distorted by edge effects. The feasibility of such configurations is supported by recent developments in materials, fabrication processes, and optical pumps. Two types of lasers can, in principle, utilize this sheet-like gain configuration in such a way that phase and gain profiles are uniformly sampled and, to first order, yield high-quality (undistorted) beams. The zig-zag laser does this with a single plate, and should be capable of power levels up to several kilowatts. The disk laser is designed around a large number of plates, and should be capable of scaling to arbitrarily high power levels.
Hearing Office Average Processing Time Ranking Report, February 2016
Social Security Administration — A ranking of ODAR hearing offices by the average number of hearings dispositions per ALJ per day. The average shown will be a combined average for all ALJs working...
ANTINOMY OF THE MODERN AVERAGE PROFESSIONAL EDUCATION
Directory of Open Access Journals (Sweden)
A. A. Listvin
2017-01-01
of ways of their decision and options of the valid upgrade of the SPE system answering to the requirements of economy. The inefficiency of the concept of one-leveled SPE and its non-competitiveness against the background of development of an applied bachelor degree at the higher school is shown. It is offered to differentiate programs of basic level for training of skilled workers and the program of the increased level for training of specialists of an average link (technicians, technologists on the basis of basic level for forming of a single system of continuous professional training and effective functioning of regional systems of professional education. Such system will help to eliminate disproportions in a triad «a worker – a technician – an engineer», and will increase the quality of professional education. Furthermore, it is indicated the need of polyprofessional education wherein the integrated educational structures differing in degree of formation of split-level educational institutions on the basis of network interaction, convergence and integration are required. According to the author, in the regions it is necessary to develop two types of organizations and SPE organizations: territorial multi-profile colleges with flexible variable programs and the organizations realizing educational programs of applied qualifications in specific industries (metallurgical, chemical, construction, etc. according to the specifics of economy of territorial subjects.Practical significance. The results of the research can be useful to specialists of management of education, heads and pedagogical staff of SPE institutions, and also representatives of regional administrations and employers while organizing the multilevel network system of training of skilled workers and experts of middle ranking.
2010-07-01
... average and corporate pool average sulfur level determined? 80.205 Section 80.205 Protection of... ADDITIVES Gasoline Sulfur Gasoline Sulfur Standards § 80.205 How is the annual refinery or importer average and corporate pool average sulfur level determined? (a) The annual refinery or importer average...
The monthly-averaged and yearly-averaged cosine effect factor of a heliostat field
Energy Technology Data Exchange (ETDEWEB)
Al-Rabghi, O.M.; Elsayed, M.M. (King Abdulaziz Univ., Jeddah (Saudi Arabia). Dept. of Thermal Engineering)
1992-01-01
Calculations are carried out to determine the dependence of the monthly-averaged and the yearly-averaged daily cosine effect factor on the pertinent parameters. The results are plotted on charts for each month and for the full year. These results cover latitude angles between 0 and 45[sup o]N, for fields with radii up to 50 tower height. In addition, the results are expressed in mathematical correlations to facilitate using them in computer applications. A procedure is outlined to use the present results to preliminary layout the heliostat field, and to predict the rated MW[sub th] reflected by the heliostat field during a period of a month, several months, or a year. (author)
Lagrangian averages, averaged Lagrangians, and the mean effects of fluctuations in fluid dynamics.
Holm, Darryl D.
2002-06-01
We begin by placing the generalized Lagrangian mean (GLM) equations for a compressible adiabatic fluid into the Euler-Poincare (EP) variational framework of fluid dynamics, for an averaged Lagrangian. This is the Lagrangian averaged Euler-Poincare (LAEP) theorem. Next, we derive a set of approximate small amplitude GLM equations (glm equations) at second order in the fluctuating displacement of a Lagrangian trajectory from its mean position. These equations express the linear and nonlinear back-reaction effects on the Eulerian mean fluid quantities by the fluctuating displacements of the Lagrangian trajectories in terms of their Eulerian second moments. The derivation of the glm equations uses the linearized relations between Eulerian and Lagrangian fluctuations, in the tradition of Lagrangian stability analysis for fluids. The glm derivation also uses the method of averaged Lagrangians, in the tradition of wave, mean flow interaction. Next, the new glm EP motion equations for incompressible ideal fluids are compared with the Euler-alpha turbulence closure equations. An alpha model is a GLM (or glm) fluid theory with a Taylor hypothesis closure. Such closures are based on the linearized fluctuation relations that determine the dynamics of the Lagrangian statistical quantities in the Euler-alpha equations. Thus, by using the LAEP theorem, we bridge between the GLM equations and the Euler-alpha closure equations, through the small-amplitude glm approximation in the EP variational framework. We conclude by highlighting a new application of the GLM, glm, and alpha-model results for Lagrangian averaged ideal magnetohydrodynamics. (c) 2002 American Institute of Physics.
Chakraborty, Mousumi; Bawuah, Prince; Tan, Nicholas; Ervasti, Tuomas; Pääkkönen, Pertti; Zeitler, J. Axel; Ketolainen, Jarkko; Peiponen, Kai-Erik
2016-08-01
In this paper, we have studied terahertz (THz) pulse time delay of porous pharmaceutical microcrystalline compacts and also pharmaceutical tablets that contain indomethacin (painkiller) as an active pharmaceutical ingredient (API) and microcrystalline cellulose as the matrix of the tablet. The porosity of a pharmaceutical tablet is important because it affects the release of drug substance. In addition, surface roughness of the tablet has much importance regarding dissolution of the tablet and hence the rate of drug release. Here, we show, using a training set of tablets containing API and with a priori known tablet's quality parameters, that the effective refractive index (obtained from THz time delay data) of such porous tablets correlates with the average surface roughness of a tablet. Hence, THz pulse time delay measurement in the transmission mode provides information on both porosity and the average surface roughness of a compact. This is demonstrated for two different sets of pharmaceutical tablets having different porosity and average surface roughness values.
Seeing and feeling volumes: The influence of shape on volume perception.
Kahrimanovic, Mirela; Bergmann Tiest, Wouter M; Kappers, Astrid M L
2010-07-01
The volume of common objects can be perceived visually, haptically or by a combination of both senses. The present study shows large effects of the object's shape on volume perception within all these modalities, with an average bias of 36%. In all conditions, the volume of a tetrahedron was overestimated compared to that of a cube or a sphere, and the volume of a cube was overestimated compared to that of a sphere. Additional analyses revealed that the biases could be explained by the dependence of the volume judgment on different geometric properties. During visual volume perception, the strategies depended on the objects that were compared and they were also subject-dependent. However, analysis of the haptic and bimodal data showed more consistent results and revealed that surface area of the stimuli influenced haptic as well as bimodal volume perception. This suggests that bimodal volume perception is more influenced by haptic input than by visual information.
[Liver damage caused by drugs].
Strohmeyer, G; Weik, C
1999-05-01
The liver has a central role in the metabolism of many drugs, since this organ is the main site of biotransformation of endo- and xenobiotics. Water-soluble drugs have a small volume of distribution and can be eliminated unchanged in the urine. By contrast, lipid-soluble drugs have a larger volume of distribution and require conversion to water-soluble metabolites for their elimination in urine or bile. The liver with its specific receptors, transporters and enzymes is responsible for the uptake, transformation and excretion of the lipophilic drugs. While most of the drugs are transformed into stable metabolites, other drugs form reactive, potentially toxic, metabolites producing liver cell damage. Liver injury caused by drugs may mimic almost any kind of liver disease. Clinical findings are gastrointestinal symptoms with nausea, vomiting and abdominal pain, cholestatic liver injury with jaundice and pruritus of severe inflammatory and cirrhotic liver damage with signs of liver failure, encephalopathy and cerebral edema. The morphological changes vary from hepatitis, cholestasis, fatty liver, granulomatous hepatitis, peri-/portal inflammation, to fibrosis with cirrhotic alterations and vascular lesions and tumors. The most commonly used drugs causing severe liver injury are discussed in detail. These are anabolics, oral contraceptives, antituberculous and antifungal agents, nonsteroidal anti-inflammatory drugs, ring substituted amphetamins ("designer drugs"), antiarrhythmics and antibiotics.
28W average power hydrocarbon-free rubidium diode pumped alkali laser.
Zweiback, Jason; Krupke, William F
2010-01-18
We present experimental results for a high-power diode pumped hydrocarbon-free rubidium laser with a scalable architecture. The laser consists of a liquid cooled, copper waveguide which serves to both guide the pump light and to provide a thermally conductive surface near the gain volume to remove heat. A laser diode stack, with a linewidth narrowed to approximately 0.35 nm with volume bragg gratings, is used to pump the cell. We have achieved 24W average power output using 4 atmospheres of naturally occurring helium ((4)He) as the buffer gas and 28W using 2.8 atmospheres of (3)He.
Intracerebroventricular administration of drugs.
Cook, Aaron M; Mieure, Katherine D; Owen, Robert D; Pesaturo, Adam B; Hatton, Jimmi
2009-07-01
Intracerebroventricular drug administration is a method that bypasses the blood-brain barrier and other mechanisms that limit drug distribution into the brain, allowing high drug concentrations to enter the central compartment. Instillation of drugs directly into the ventricles of the brain must be done carefully and with full consideration of factors affecting the efficacy and safety of this route of administration. These factors include the osmolarity, pH, volume, and presence of preservatives and diluents of the drug solution being administered. Very few studies have formally investigated intraventricular therapies, and dosing recommendations may vary widely depending on the agent and the patient. Many antimicrobials have been given intraventricularly, although very few prospective studies have evaluated this strategy. There are wide variations among the reports regarding dosage regimens and the pharmacokinetics of the antimicrobials used. Guidance on appropriate formulations and their use is lacking. Clinicians should be aware of their patients' ongoing disease processes and neurologic status, as well as pertinent physiochemical properties of drugs when formulating them for intracerebroventricular administration; a high index of suspicion should be maintained when monitoring patients for adverse drug events after instillation.
Liu, Xiaojia; An, Haizhong; Wang, Lijun; Guan, Qing
2017-09-01
The moving average strategy is a technical indicator that can generate trading signals to assist investment. While the trading signals tell the traders timing to buy or sell, the moving average cannot tell the trading volume, which is a crucial factor for investment. This paper proposes a fuzzy moving average strategy, in which the fuzzy logic rule is used to determine the strength of trading signals, i.e., the trading volume. To compose one fuzzy logic rule, we use four types of moving averages, the length of the moving average period, the fuzzy extent, and the recommend value. Ten fuzzy logic rules form a fuzzy set, which generates a rating level that decides the trading volume. In this process, we apply genetic algorithms to identify an optimal fuzzy logic rule set and utilize crude oil futures prices from the New York Mercantile Exchange (NYMEX) as the experiment data. Each experiment is repeated for 20 times. The results show that firstly the fuzzy moving average strategy can obtain a more stable rate of return than the moving average strategies. Secondly, holding amounts series is highly sensitive to price series. Thirdly, simple moving average methods are more efficient. Lastly, the fuzzy extents of extremely low, high, and very high are more popular. These results are helpful in investment decisions.
40 CFR 1033.710 - Averaging emission credits.
2010-07-01
... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Averaging emission credits. 1033.710... Averaging emission credits. (a) Averaging is the exchange of emission credits among your engine families. You may average emission credits only as allowed by § 1033.740. (b) You may certify one or more engine...
7 CFR 51.577 - Average midrib length.
2010-01-01
... 7 Agriculture 2 2010-01-01 2010-01-01 false Average midrib length. 51.577 Section 51.577... STANDARDS) United States Standards for Celery Definitions § 51.577 Average midrib length. Average midrib length means the average length of all the branches in the outer whorl measured from the point...
7 CFR 760.640 - National average market price.
2010-01-01
... 7 Agriculture 7 2010-01-01 2010-01-01 false National average market price. 760.640 Section 760.640....640 National average market price. (a) The Deputy Administrator will establish the National Average... average quality loss factors that are reflected in the market by county or part of a county. (c)...
Dictionary Based Segmentation in Volumes
DEFF Research Database (Denmark)
Emerson, Monica Jane; Jespersen, Kristine Munk; Jørgensen, Peter Stanley
2015-01-01
We present a method for supervised volumetric segmentation based on a dictionary of small cubes composed of pairs of intensity and label cubes. Intensity cubes are small image volumes where each voxel contains an image intensity. Label cubes are volumes with voxelwise probabilities for a given...... label. The segmentation process is done by matching a cube from the volume, of the same size as the dictionary intensity cubes, to the most similar intensity dictionary cube, and from the associated label cube we get voxel-wise label probabilities. Probabilities from overlapping cubes are averaged...... and hereby we obtain a robust label probability encoding. The dictionary is computed from labeled volumetric image data based on weighted clustering. We experimentally demonstrate our method using two data sets from material science – a phantom data set of a solid oxide fuel cell simulation for detecting...
Kinetic energy equations for the average-passage equation system
Johnson, Richard W.; Adamczyk, John J.
1989-01-01
Important kinetic energy equations derived from the average-passage equation sets are documented, with a view to their interrelationships. These kinetic equations may be used for closing the average-passage equations. The turbulent kinetic energy transport equation used is formed by subtracting the mean kinetic energy equation from the averaged total instantaneous kinetic energy equation. The aperiodic kinetic energy equation, averaged steady kinetic energy equation, averaged unsteady kinetic energy equation, and periodic kinetic energy equation, are also treated.
Kinetic energy equations for the average-passage equation system
Johnson, Richard W.; Adamczyk, John J.
1989-01-01
Important kinetic energy equations derived from the average-passage equation sets are documented, with a view to their interrelationships. These kinetic equations may be used for closing the average-passage equations. The turbulent kinetic energy transport equation used is formed by subtracting the mean kinetic energy equation from the averaged total instantaneous kinetic energy equation. The aperiodic kinetic energy equation, averaged steady kinetic energy equation, averaged unsteady kinetic energy equation, and periodic kinetic energy equation, are also treated.
Operational analysis for the drug detection problem
Hoopengardner, Roger L.; Smith, Michael C.
1994-10-01
New techniques and sensors to identify the molecular, chemical, or elemental structures unique to drugs are being developed under several national programs. However, the challenge faced by U.S. drug enforcement and Customs officials goes far beyond the simple technical capability to detect an illegal drug. Entry points into the U.S. include ports, border crossings, and airports where cargo ships, vehicles, and aircraft move huge volumes of freight. Current technology and personnel are able to physically inspect only a small fraction of the entering cargo containers. The complexities of how to best utilize new technology to aid the detection process and yet not adversely affect the processing of vehicles and time-sensitive cargo is the challenge faced by these officials. This paper describes an ARPA sponsored initiative to develop a simple, yet useful, method for examining the operational consequences of utilizing various procedures and technologies in combination to achieve an `acceptable' level of detection probability. Since Customs entry points into the U.S. vary from huge seaports to a one lane highway checkpoint between the U.S. and Canadian or Mexico border, no one system can possibly be right for all points. This approach can examine alternative concepts for using different techniques/systems for different types of entry points. Operational measures reported include the average time to process vehicles and containers, the average and maximum numbers in the system at any time, and the utilization of inspection teams. The method is implemented via a PC-based simulation written in GPSS-PC language. Input to the simulation model is (1) the individual detection probabilities and false positive rates for each detection technology or procedure, (2) the inspection time for each procedure, (3) the system configuration, and (4) the physical distance between inspection stations. The model offers on- line graphics to examine effects as the model runs.
21 CFR 862.1130 - Blood volume test system.
2010-04-01
... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Blood volume test system. 862.1130 Section 862.1130 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES Clinical Chemistry Test Systems §...
Yu, Yun; Chen, Chih-Kuang; Law, Wing-Cheung; Weinheimer, Emily; Sengupta, Sanghamitra; Prasad, Paras N; Cheng, Chong
2014-02-10
Nanoparticles (NPs) with high drug loading and pH-responsivity were prepared by nanoprecipitation of a hydrophobic polymer-drug conjugate (PDC). The PDC, polylactide-graft-doxorubicin (PLA-g-DOX), was synthesized by azide-alkyne click reaction to transform acetylene-functionalized PLA into PLA-graft-aldehyde (PLA-g-ALD), followed by DOX conjugation to form acid-sensitive Schiff base linkage between drug moieties and polymer scaffold. The DOX loading amount in PLA-g-DOX PDC was determined to be 32 wt % by (1)H NMR and UV-vis spectroscopies. PLA-g-DOX PDC was further used to prepare NPs with precisely controlled drug loading by nanoprecipitation in the presence of a PEGylated surfactant. The effects of organic solvent, PLA-g-DOX PDC concentration and PLA-g-DOX/surfactant mass ratio on size and size distribution of NPs were systematically examined based on analysis by dynamic light scattering (DLS) and transmission electron microscopy (TEM). NPs prepared under the optimal conditions exhibited well-defined spherical morphology with volume-average hydrodynamic diameter (Dh) around 100 nm. Due to the Schiff base conjugation linkage in PLA-g-DOX PDC, acid-sensitive drug release behavior of the NPs was observed. In vitro studies against MCF-7 breast cancer cells showed that the NPs can be readily taken up and result in enhanced therapeutic efficiency as compared to DOX·HCl, indicating their promising potential applications as anticancer nanomedicines.
Mesoporous Calcium Silicate Nanoparticles with Drug Delivery and Odontogenesis Properties.
Huang, Ching-Yuang; Huang, Tsui-Hsien; Kao, Chia-Tze; Wu, Yuan-Haw; Chen, Wan-Chen; Shie, Ming-You
2017-01-01
Calcium silicate (CS) -based materials play an important role in the development of endodontic materials that induce bone/cementum tissue regeneration and inhibit bacterial viability. The aim of this study was to prepare novel mesoporous CS (MesoCS) nanoparticles that have osteogenic, drug delivery, and antibacterial characteristics for endodontic materials and also have an excellent ability to develop apatite mineralization. The MesoCS nanoparticles were prepared using sol-gel methods. In addition, the mesoporous structure, specific surface area, pore volume, and morphology of the MesoCS nanoparticles were analyzed. The apatite mineralization ability, in vitro odontogenic differentiation, drug delivery, and antibacterial properties of the MesoCS nanoparticles were further investigated. The results indicate that the 200-nm-sized MesoCS nanoparticles synthesized using a facile template method exhibited a high specific surface area and pore volume with internal mesopores (average pore size = 3.05 nm). Furthermore, the MesoCS nanoparticles can be used as drug carriers to maintain sustained release of gentamicin and fibroblast growth factor-2 (FGF-2). The MesoCS-loaded FGF-2 might stimulate more odontogenic-related protein than CS because of the FGF-2 release. Based on this work, it can be inferred that MesoCS nanoparticles are potentially useful endodontic materials for biocompatible and osteogenic dental pulp tissue regenerative materials. Copyright © 2016 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
Brodniewicz, Teresa; Grynkiewicz, Grzegorz
2010-01-01
Life sciences provide reasonably sound prognosis for a number and nature of therapeutic targets on which drug design could be based, and search for new chemical entities--future new drugs, is now more than ever based on scientific principles. Nevertheless, current very long and incredibly costly drug discovery and development process is very inefficient, with attrition rate spanning from many thousands of new chemical structures, through a handful of validated drug leads, to single successful new drug launches, achieved in average after 13 years, with compounded cost estimates from hundreds of thousands to over one billion US dollars. Since radical pharmaceutical innovation is critically needed, number of new research projects concerning this area is steeply rising outside of big pharma industry--both in academic environment and in small private companies. Their prospective success will critically depend on project management, which requires combined knowledge of scientific, technical and legal matters, comprising regulations concerning admission of new drug candidates to be subjects of clinical studies. This paper attempts to explain basic rules and requirements of drug development within preclinical study period, in case of new chemical entities of natural or synthetic origin, which belong to low molecular weight category.
Prom-Wormley, Elizabeth; Maes, Hermine H.M.; Schmitt, J. Eric; Panizzon, Matthew S.; Xian, Hong; Eyler, Lisa T.; Franz, Carol E.; Lyons, Michael J.; Tsuang, Ming T.; Dale, Anders M.; Fennema-Notestine, Christine; Kremen, William S.; Neale, Michael C.
2015-01-01
Chronic cigarette use has been consistently associated with differences in the neuroanatomy of smokers relative to nonsmokers in case-control studies. However, the etiology underlying the relationships between brain structure and cigarette use is unclear. A community-based sample of male twin pairs ages 51-59 (110 monozygotic pairs, 92 dizygotic pairs) was used to determine the extent to which there are common genetic and environmental influences between brain structure and average lifetime cigarette use. Brain structure was measured by high-resolution structural magnetic resonance imaging, from which subcortical volume and cortical volume, thickness and surface area were derived. Bivariate genetic models were fitted between these measures and average lifetime cigarette use measured as cigarette pack-years. Widespread, negative phenotypic correlations were detected between cigarette pack-years and several cortical as well as subcortical structures. Shared genetic and unique environmental factors contributed to the phenotypic correlations shared between cigarette pack-years and subcortical volume as well as cortical volume and surface area. Brain structures involved in many of the correlations were previously reported to play a role in specific aspects of networks of smoking-related behaviors. These results provide evidence for conducting future research on the etiology of smoking-related behaviors using measures of brain morphology. PMID:25690561
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... Parents & Educators Children & Teens Search Connect with NIDA : Google Plus Facebook LinkedIn Twitter YouTube Flickr RSS Menu ... misuse of prescription drugs can make driving a car unsafe—just like driving after drinking alcohol. Drugged ...
Full Text Available ... abuse, addiction, and treatment. Watch Videos Information About Drugs Alcohol Bath Salts Cocaine Heroin Marijuana MDMA Meth ... 662-HELP (4357) at any time to find drug treatment centers near you. I want my daughter ...
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... study drugs: amphetamines like Adderall, Dexedrine, or Vyvanse methylphenidates like Ritalin or Concerta Most people get study ... How Much Sleep Do I Need? Prescription Drug Abuse How to Make Homework Less Work Organizing Schoolwork & ...
Full Text Available ... abuse, addiction, and treatment. Watch Videos Information About Drugs Alcohol Bath Salts Cocaine Heroin Marijuana MDMA Meth ... 662-HELP (4357) at any time to find drug treatment centers near you. I want my daughter ...
Full Text Available ... form Search Menu Home Drugs That People Abuse Alcohol Facts Bath Salts Facts Cocaine (Coke, Crack) Facts ... addiction, and treatment. Watch Videos Information About Drugs Alcohol Bath Salts Cocaine Heroin Marijuana MDMA Meth Pain ...
... Drugs for fever, cough, stuffy nose, runny nose, diarrhea, and allergies are common drugs which are especially helpful during times of illness. All medications should be kept out of the reach of children.
... drug. "Max" was addicted to prescription drugs. The addiction slowly took over his life. I need different people around me. To stop using marijuana, "Cristina" is making positive changes in her life. She finds support from ...
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Chen, Chi-Liang; Chen, Likwang; Yang, Wei-Chih
2008-04-12
-action period to the post-action period for the exposure group. The average magnitudes of the decreases for the three classes of drugs mentioned above were 14.8%, 5.8% and 5.8%, respectively. In contrast, there was no reduction for the comparison group. The number of days of the prescription increased significantly from the pre- to the post-action period for both exposure and comparison groups. The total expense also significantly increased for both patient groups. For the exposure group, the average magnitudes of the growth in the total expenditure for the three classes of drugs were 47.7%, 60.0% and 55.3%, respectively. For the comparison group, they were 91.6%, 91.6% and 63.2%, respectively. After the action, approximately 50% of patients obtained more than 180 days of prescription drugs for a six-month period. The 2001 price adjustment action, based on generic grouping, significantly reduced the daily expense of each of the three classes of cardiovascular drugs. However, in response to this policy change, hospitals in Taiwan tended to greatly expand the volume of drugs prescribed for their regular patients. Consequently, the total expenditures for the three classes of drugs grew substantially after the action. These knock-on effects weakened the capability of the price adjustment action to control total pharmaceutical expenditures. This means that no saved resources were available for other health care uses. Such expansion of pharmaceutical consumption might also lead to inefficient use of the three drug classes: a large proportion of patients obtained more than one day of drugs per day in the post-action period, suggesting manipulation to increase reimbursement and offset price controls. We recommend that Taiwan's government use the NHI data to establish a monitoring system to detect inappropriate prescription patterns before implementing future policy changes. Such a monitoring system could then be used to deter hospitals from abusing their prescription volumes, making it
Directory of Open Access Journals (Sweden)
Chen Likwang
2008-04-01
drug expense significantly decreased from the pre-action period to the post-action period for the exposure group. The average magnitudes of the decreases for the three classes of drugs mentioned above were 14.8%, 5.8% and 5.8%, respectively. In contrast, there was no reduction for the comparison group. The number of days of the prescription increased significantly from the pre- to the post-action period for both exposure and comparison groups. The total expense also significantly increased for both patient groups. For the exposure group, the average magnitudes of the growth in the total expenditure for the three classes of drugs were 47.7%, 60.0% and 55.3%, respectively. For the comparison group, they were 91.6%, 91.6% and 63.2%, respectively. After the action, approximately 50% of patients obtained more than 180 days of prescription drugs for a six-month period. Conclusion The 2001 price adjustment action, based on generic grouping, significantly reduced the daily expense of each of the three classes of cardiovascular drugs. However, in response to this policy change, hospitals in Taiwan tended to greatly expand the volume of drugs prescribed for their regular patients. Consequently, the total expenditures for the three classes of drugs grew substantially after the action. These knock-on effects weakened the capability of the price adjustment action to control total pharmaceutical expenditures. This means that no saved resources were available for other health care uses. Such expansion of pharmaceutical consumption might also lead to inefficient use of the three drug classes: a large proportion of patients obtained more than one day of drugs per day in the post-action period, suggesting manipulation to increase reimbursement and offset price controls. We recommend that Taiwan's government use the NHI data to establish a monitoring system to detect inappropriate prescription patterns before implementing future policy changes. Such a monitoring system could then be used
Average annual runoff in the United States, 1951-80
U.S. Geological Survey, Department of the Interior — This is a line coverage of average annual runoff in the conterminous United States, 1951-1980. Surface runoff Average runoff Surface waters United States
Seasonal Sea Surface Temperature Averages, 1985-2001 - Direct Download
U.S. Geological Survey, Department of the Interior — This data set consists of four images showing seasonal sea surface temperature (SST) averages for the entire earth. Data for the years 1985-2001 are averaged to...
Average American 15 Pounds Heavier Than 20 Years Ago
... page: https://medlineplus.gov/news/fullstory_160233.html Average American 15 Pounds Heavier Than 20 Years Ago ... since the late 1980s and early 1990s, the average American has put on 15 or more additional ...
Directory of Open Access Journals (Sweden)
Warrington Richard
2011-11-01
Full Text Available Abstract Drug allergy encompasses a spectrum of immunologically-mediated hypersensitivity reactions with varying mechanisms and clinical presentations. This type of adverse drug reaction (ADR not only affects patient quality of life, but may also lead to delayed treatment, unnecessary investigations, and even mortality. Given the myriad of symptoms associated with the condition, diagnosis is often challenging. Therefore, referral to an allergist experienced in the identification, diagnosis and management of drug allergy is recommended if a drug-induced allergic reaction is suspected. Diagnosis relies on a careful history and physical examination. In some instances, skin testing, graded challenges and induction of drug tolerance procedures may be required. The most effective strategy for the management of drug allergy is avoidance or discontinuation of the offending drug. When available, alternative medications with unrelated chemical structures should be substituted. Cross-reactivity among drugs should be taken into consideration when choosing alternative agents. Additional therapy for drug hypersensitivity reactions is largely supportive and may include topical corticosteroids, oral antihistamines and, in severe cases, systemic corticosteroids. In the event of anaphylaxis, the treatment of choice is injectable epinephrine. If a particular drug to which the patient is allergic is indicated and there is no suitable alternative, induction of drug tolerance procedures may be considered to induce temporary tolerance to the drug. This article provides a backgrounder on drug allergy and strategies for the diagnosis and management of some of the most common drug-induced allergic reactions, such allergies to penicillin, sulfonamides, cephalosporins, radiocontrast media, local anesthetics, general anesthetics, acetylsalicylic acid (ASA and non-steroidal anti-inflammatory drugs.
Trait valence and the better-than-average effect.
Gold, Ron S; Brown, Mark G
2011-12-01
People tend to regard themselves as having superior personality traits compared to their average peer. To test whether this "better-than-average effect" varies with trait valence, participants (N = 154 students) rated both themselves and the average student on traits constituting either positive or negative poles of five trait dimensions. In each case, the better-than-average effect was found, but trait valence had no effect. Results were discussed in terms of Kahneman and Tversky's prospect theory.
Investigating Averaging Effect by Using Three Dimension Spectrum
Institute of Scientific and Technical Information of China (English)
无
2005-01-01
The eddy current displacement sensor's averaging effect has been investigated in this paper,and thefrequency spectrum property of the averaging effect was also deduced. It indicates that the averaging effect has no influences on measuring a rotor's rotating error, but it has visible influences on measuring the rotor's profile error. According to the frequency spectrum of the averaging effect, the actual sampling data can be adjusted reasonably, thus measuring precision is improved.
Average of Distribution and Remarks on Box-Splines
Institute of Scientific and Technical Information of China (English)
LI Yue-sheng
2001-01-01
A class of generalized moving average operators is introduced, and the integral representations of an average function are provided. It has been shown that the average of Dirac δ-distribution is just the well known box-spline. Some remarks on box-splines, such as their smoothness and the corresponding partition of unity, are made. The factorization of average operators is derived. Then, the subdivision algorithm for efficient computing of box-splines and their linear combinations follows.
Scalable Robust Principal Component Analysis Using Grassmann Averages
DEFF Research Database (Denmark)
Hauberg, Søren; Feragen, Aasa; Enficiaud, Raffi
2016-01-01
provide a simple algorithm for computing this Grassmann Average (GA), and show that the subspace estimate is less sensitive to outliers than PCA for general distributions. Because averages can be efficiently computed, we immediately gain scalability. We exploit robust averaging to formulate the Robust...
Averaging and Globalising Quotients of Informetric and Scientometric Data.
Egghe, Leo; Rousseau, Ronald
1996-01-01
Discussion of impact factors for "Journal Citation Reports" subject categories focuses on the difference between an average of quotients and a global average, obtained as a quotient of averages. Applications in the context of informetrics and scientometrics are given, including journal prices and subject discipline influence scores.…
Perturbation resilience and superiorization methodology of averaged mappings
He, Hongjin; Xu, Hong-Kun
2017-04-01
We first prove the bounded perturbation resilience for the successive fixed point algorithm of averaged mappings, which extends the string-averaging projection and block-iterative projection methods. We then apply the superiorization methodology to a constrained convex minimization problem where the constraint set is the intersection of fixed point sets of a finite family of averaged mappings.
Spectral averaging techniques for Jacobi matrices with matrix entries
Sadel, Christian
2009-01-01
A Jacobi matrix with matrix entries is a self-adjoint block tridiagonal matrix with invertible blocks on the off-diagonals. Averaging over boundary conditions leads to explicit formulas for the averaged spectral measure which can potentially be useful for spectral analysis. Furthermore another variant of spectral averaging over coupling constants for these operators is presented.
76 FR 6161 - Annual Determination of Average Cost of Incarceration
2011-02-03
... No: 2011-2363] DEPARTMENT OF JUSTICE Bureau of Prisons Annual Determination of Average Cost of Incarceration AGENCY: Bureau of Prisons, Justice. ACTION: Notice. SUMMARY: The fee to cover the average cost of incarceration for Federal inmates in Fiscal Year 2009 was $25,251. The average annual cost to confine an...
20 CFR 226.62 - Computing average monthly compensation.
2010-04-01
... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Computing average monthly compensation. 226... Compensation § 226.62 Computing average monthly compensation. The employee's average monthly compensation is computed by first determining the employee's highest 60 months of railroad compensation...
40 CFR 1042.710 - Averaging emission credits.
2010-07-01
... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Averaging emission credits. 1042.710..., Banking, and Trading for Certification § 1042.710 Averaging emission credits. (a) Averaging is the exchange of emission credits among your engine families. (b) You may certify one or more engine families to...
27 CFR 19.37 - Average effective tax rate.
2010-04-01
... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Average effective tax rate..., DEPARTMENT OF THE TREASURY LIQUORS DISTILLED SPIRITS PLANTS Taxes Effective Tax Rates § 19.37 Average effective tax rate. (a) The proprietor may establish an average effective tax rate for any...
7 CFR 51.2561 - Average moisture content.
2010-01-01
... 7 Agriculture 2 2010-01-01 2010-01-01 false Average moisture content. 51.2561 Section 51.2561... STANDARDS) United States Standards for Grades of Shelled Pistachio Nuts § 51.2561 Average moisture content. (a) Determining average moisture content of the lot is not a requirement of the grades, except...
20 CFR 404.220 - Average-monthly-wage method.
2010-04-01
... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Average-monthly-wage method. 404.220 Section... INSURANCE (1950- ) Computing Primary Insurance Amounts Average-Monthly-Wage Method of Computing Primary Insurance Amounts § 404.220 Average-monthly-wage method. (a) Who is eligible for this method. You...
7 CFR 1410.44 - Average adjusted gross income.
2010-01-01
... 7 Agriculture 10 2010-01-01 2010-01-01 false Average adjusted gross income. 1410.44 Section 1410... Average adjusted gross income. (a) Benefits under this part will not be available to persons or legal entities whose average adjusted gross income exceeds $1,000,000 or as further specified in part...
18 CFR 301.7 - Average System Cost methodology functionalization.
2010-04-01
... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Average System Cost... REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS FOR FEDERAL POWER MARKETING ADMINISTRATIONS AVERAGE... ACT § 301.7 Average System Cost methodology functionalization. (a) Functionalization of each...
47 CFR 80.759 - Average terrain elevation.
2010-10-01
... 47 Telecommunication 5 2010-10-01 2010-10-01 false Average terrain elevation. 80.759 Section 80... Average terrain elevation. (a)(1) Draw radials from the antenna site for each 45 degrees of azimuth.... (d) Average the values by adding them and dividing by the number of readings along each radial....
34 CFR 668.196 - Average rates appeals.
2010-07-01
... 34 Education 3 2010-07-01 2010-07-01 false Average rates appeals. 668.196 Section 668.196....196 Average rates appeals. (a) Eligibility. (1) You may appeal a notice of a loss of eligibility under... calculated as an average rate under § 668.183(d)(2). (2) You may appeal a notice of a loss of...
20 CFR 404.221 - Computing your average monthly wage.
2010-04-01
... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Computing your average monthly wage. 404.221... DISABILITY INSURANCE (1950- ) Computing Primary Insurance Amounts Average-Monthly-Wage Method of Computing Primary Insurance Amounts § 404.221 Computing your average monthly wage. (a) General. Under the...
34 CFR 668.215 - Average rates appeals.
2010-07-01
... 34 Education 3 2010-07-01 2010-07-01 false Average rates appeals. 668.215 Section 668.215... Average rates appeals. (a) Eligibility. (1) You may appeal a notice of a loss of eligibility under § 668... as an average rate under § 668.202(d)(2). (2) You may appeal a notice of a loss of eligibility...
7 CFR 51.2548 - Average moisture content determination.
2010-01-01
... 7 Agriculture 2 2010-01-01 2010-01-01 false Average moisture content determination. 51.2548..., AND STANDARDS) United States Standards for Grades of Pistachio Nuts in the Shell § 51.2548 Average moisture content determination. (a) Determining average moisture content of the lot is not a requirement...
Buchert, Thomas; Wiegand, Alexander
2013-01-01
Kinematical and dynamical properties of a generic inhomogeneous cosmological model, spatially averaged with respect to free-falling (generalized fundamental) observers, are investigated for the matter model `irrotational dust'. Paraphrasing a previous Newtonian investigation, we present a relativistic generalization of a backreaction model based on volume-averaging the `Relativistic Zel'dovich Approximation'. In this model we investigate the effect of `kinematical backreaction' on the evolution of cosmological parameters as they are defined in an averaged inhomogenous cosmology, and we show that the backreaction model interpolates between orthogonal symmetry properties by covering subcases of the plane-symmetric solution, the Lemaitre-Tolman-Bondi solution and the Szekeres solution. We so obtain a powerful model that lays the foundations for quantitatively addressing curvature inhomogeneities as they would be interpreted as `Dark Energy' or `Dark Matter' in a quasi-Newtonian cosmology. The present model, havi...
Source of non-arrhenius average relaxation time in glass-forming liquids
DEFF Research Database (Denmark)
Dyre, Jeppe
1998-01-01
then discuss a recently proposed model according to which the activation energy of the average relaxation time is determined by the work done in shoving aside the surrounding liquid to create space needed for a "flow event". In this model, which is based on the fact that intermolecular interactions......A major mystery of glass-forming liquids is the non-Arrhenius temperature-dependence of the average relaxation time. This paper briefly reviews the classical phenomenological models for non-Arrhenius behavior the free volume model and the entropy model and critiques against these models. We...... are anharmonic, the non-Arrhenius temperature-dependence of the average relaxation time is a consequence of the fact that the instantaneous shear modulus increases upon cooling....
Size and average density spectra of macromolecules obtained from hydrodynamic data.
Pavlov, G M
2007-02-01
It is proposed to normalize the Mark-Kuhn-Houwink-Sakurada type of equation relating the hydrodynamic characteristics, such as intrinsic viscosity, velocity sedimentation coefficient and translational diffusion coefficient of linear macromolecules to their molecular masses for the values of linear density M(L) and the statistical segment length A. When the set of data covering virtually all known experimental information is normalized for M(L), it is presented as a size spectrum of linear polymer molecules. Further normalization for the A value reduces all data to two regions: namely the region exhibiting volume interactions and that showing hydrodynamic draining. For chains without intachain excluded volume effects these results may be reproduced using the Yamakawa-Fujii theory of wormlike cylinders. Data analyzed here cover a range of contour lengths of linear chains varying by three orders of magnitude, with the range of statistical segment lengths varying approximately 500 times. The plot of the dependence of [eta]M on M represents the spectrum of average specific volumes occupied by linear and branched macromolecules. Dendrimers and globular proteins for which the volume occupied by the molecule in solution is directly proportional to M have the lowest specific volume. The homologous series of macromolecules in these plots are arranged following their fractal dimensionality.
Directory of Open Access Journals (Sweden)
De Pintu Kumar
2012-12-01
Full Text Available Approximately 40% of lipophilic drug candidates fail to comply the commercial requirements of solubility and formulation stability, prompting significant research activity in advanced lipophile delivery technologies. Solid lipid nanoparticle (SLN technology represents a promising new approach to lipophile drug delivery. Solid lipid nanoparticles typically are spherical with average diameters between 1 to 1000 nanometers. SLNs possess a solid lipid core matrix that can solubilize lipophilic molecules. The lipid core is stabilized by surfactants. Primary objective of this study is to enhance the solubility and dissolution rate of Ibuprofen by formulation into SLN using hot homogenization method. Further, this study also investigates the effect of various formulation parameters like stabilizer concentration, surfactant ratio, Lipid ratio and drug loading. SLNs were characterized for size distribution, entrapment efficiency, drug release and stability. SLN of Ibuprofen was prepared using stearic acid (lipid Phospholipon 80 H (surfactant and Tween-80 as stabilizer. The FTIR study shows no major interaction of Ibuprofen with other formulation ingredients, and the Differential Scanning Calorimetry (DSC study revealed that the drug is molecularly dispersed into the lipid. The particle size determinations confirm the particle size distribution in the nanoparticular range (27% Volume to 56% volume. In-vitro drug release through the dialysis membrane from the prepared SLNs is much higher than the pure drug. The stability study indicates the stability of the formulations without changing its performance on storage. Hence formulation of Ibuprofen in SLN enhances the dissolution rate as well as it will enhance the bioavailability of the drug which could be stabilized during storage.
Fluctuations of trading volume in a stock market
Hong, Byoung Hee; Lee, Kyoung Eun; Hwang, Jun Kyung; Lee, Jae Woo
2009-03-01
We consider the probability distribution function of the trading volume and the volume changes in the Korean stock market. The probability distribution function of the trading volume shows double peaks and follows a power law, P(V/)∼( at the tail part of the distribution with α=4.15(4) for the KOSPI (Korea composite Stock Price Index) and α=4.22(2) for the KOSDAQ (Korea Securities Dealers Automated Quotations), where V is the trading volume and is the monthly average value of the trading volume. The second peaks originate from the increasing trends of the average volume. The probability distribution function of the volume changes also follows a power law, P(Vr)∼Vr-β, where Vr=V(t)-V(t-T) and T is a time lag. The exponents β depend on the time lag T. We observe that the exponents β for the KOSDAQ are larger than those for the KOSPI.
[Drugs and lactation. Part 2].
Alerany Pardo, C; Bassons Boncompte, M T; Font Pous, M
1986-01-01
This document lists categories of drugs and provides brief descriptions of the effects on lactation and nursing infants of specific drugs within categories. Because any drug may pass to some extent to the mother's milk, the effect on the infant must always be considered before a drug is given to the mother. This review provides information on the excretion of drugs through breast milk and identifies drugs that are contraindicated for nursing mothers. The medications considered include drugs for gastrointestinal pathology, drugs for the central nervous system, hormones and hormone substitution drugs, radioisotopes, vitamins and minerals, foods and additives, social toxics such as nicotine and caffeine, and environmental agents. Among hormones and hormone substitution drugs, combinations of estrogens, estrogens and progestins, or estrogens and androgens at high doses may suppress lactation. Low doses of oral contraceptives (OCs) have slight effects on the volume of milk but may suppress lactation in women in whom lactation is not established. OCs also alter the composition of milk, although the changes are within normal limits and their clinical significance is not clear. Cases have been described in which OCs have caused breast development in boys and proliferation of vaginal epithelium in girls, although the causal relationship has not been proven. Androgens are contraindicated because they may cause masculinization of girls or precocious development in boys. Doses of over 50 mcg/day of ethinyl estradiol diminish milk production and may produce feminization of boys. Mestranol at doses of under 100 mcg/day produces insignificant levels in milk.
Averaging and sampling for magnetic-observatory hourly data
Directory of Open Access Journals (Sweden)
J. J. Love
2010-11-01
Full Text Available A time and frequency-domain analysis is made of the effects of averaging and sampling methods used for constructing magnetic-observatory hourly data values. Using 1-min data as a proxy for continuous, geomagnetic variation, we construct synthetic hourly values of two standard types: instantaneous "spot" measurements and simple 1-h "boxcar" averages. We compare these average-sample types with others: 2-h average, Gaussian, and "brick-wall" low-frequency-pass. Hourly spot measurements provide a statistically unbiased representation of the amplitude range of geomagnetic-field variation, but as a representation of continuous field variation over time, they are significantly affected by aliasing, especially at high latitudes. The 1-h, 2-h, and Gaussian average-samples are affected by a combination of amplitude distortion and aliasing. Brick-wall values are not affected by either amplitude distortion or aliasing, but constructing them is, in an operational setting, relatively more difficult than it is for other average-sample types. It is noteworthy that 1-h average-samples, the present standard for observatory hourly data, have properties similar to Gaussian average-samples that have been optimized for a minimum residual sum of amplitude distortion and aliasing. For 1-h average-samples from medium and low-latitude observatories, the average of the combination of amplitude distortion and aliasing is less than the 5.0 nT accuracy standard established by Intermagnet for modern 1-min data. For medium and low-latitude observatories, average differences between monthly means constructed from 1-min data and monthly means constructed from any of the hourly average-sample types considered here are less than the 1.0 nT resolution of standard databases. We recommend that observatories and World Data Centers continue the standard practice of reporting simple 1-h-average hourly values.
Directory of Open Access Journals (Sweden)
Goločorbin-Kon Svetlana
2013-01-01
Full Text Available Introduction. Drugs used for treatment of rare diseases are known worldwide under the term of orphan drugs because pharmaceutical companies have not been interested in ”adopting” them, that is in investing in research, developing and producing these drugs. This kind of policy has been justified by the fact that these drugs are targeted for small markets, that only a small number of patients is available for clinical trials, and that large investments are required for the development of drugs meant to treat diseases whose pathogenesis has not yet been clarified in majority of cases. The aim of this paper is to present previous and present status of orphan drugs in Serbia and other countries. The beginning of orphan drugs development. This problem was first recognized by Congress of the United States of America in January 1983, and when the ”Orphan Drug Act” was passed, it was a turning point in the development of orphan drugs. This law provides pharmaceutical companies with a series of reliefs, both financial ones that allow them to regain funds invested into the research and development and regulatory ones. Seven years of marketing exclusivity, as a type of patent monopoly, is the most important relief that enables companies to make large profits. Conclusion. There are no sufficient funds and institutions to give financial support to the patients. It is therefore necessary to make health professionals much more aware of rare diseases in order to avoid time loss in making the right diagnosis and thus to gain more time to treat rare diseases. The importance of discovery, development and production of orphan drugs lies in the number of patients whose life quality can be improved significantly by administration of these drugs as well as in the number of potential survivals resulting from the treatment with these drugs. [Projekat Ministarstva nauke Republike Srbije, br. III 41012
Lifescience Database Archive (English)
Full Text Available D06416 Mixture, Drug Cresol solution (JP16) Saponated cresol solution [DR:D06417], ...Water [DR:D00001] Cresol solution is included 1.25-1.60 volume percent Cresol [DR:D01960] PubChem: 47208072 ...
... Anabolic) Synthetic Cannabinoids (K2/Spice) Synthetic Cathinones (Bath Salts) Tobacco/Nicotine Other Drugs Related Topics Addiction Science Adolescent Brain Comorbidity College-Age & Young Adults ...
Averaging VMAT treatment plans for multi-criteria navigation
Craft, David; Unkelbach, Jan
2013-01-01
The main approach to smooth Pareto surface navigation for radiation therapy multi-criteria treatment planning involves taking real-time averages of pre-computed treatment plans. In fluence-based treatment planning, fluence maps themselves can be averaged, which leads to the dose distributions being averaged due to the linear relationship between fluence and dose. This works for fluence-based photon plans and proton spot scanning plans. In this technical note, we show that two or more sliding window volumetric modulated arc therapy (VMAT) plans can be combined by averaging leaf positions in a certain way, and we demonstrate that the resulting dose distribution for the averaged plan is approximately the average of the dose distributions of the original plans. This leads to the ability to do Pareto surface navigation, i.e. interactive multi-criteria exploration of VMAT plan dosimetric tradeoffs.
Averaging and exact perturbations in LTB dust models
Sussman, Roberto A
2012-01-01
We introduce a scalar weighed average ("q-average") acting on concentric comoving domains in spherically symmetric Lemaitre-Tolman-Bondi (LTB) dust models. The resulting averaging formalism allows for an elegant coordinate independent dynamical study of the models, providing as well a valuable theoretical insight on the properties of scalar averaging in inhomogeneous spacetimes. The q-averages of those covariant scalars common to FLRW models (the "q-scalars") identically satisfy FLRW evolution laws and determine for every domain a unique FLRW background state. All curvature and kinematic proper tensors and their invariant contractions are expressible in terms of the q-scalars and their linear and quadratic local fluctuations, which convey the effects of inhomogeneity through the ratio of Weyl to Ricci curvature invariants and the magnitude of radial gradients. We define also non-local fluctuations associated with the intuitive notion of a "contrast" with respect to FLRW reference averaged values assigned to a...
Multiplexed Dosing Assays by Digitally Definable Hydrogel Volumes
DEFF Research Database (Denmark)
Faralli, Adele; Melander, Fredrik; Larsen, Esben Kjær Unmack
2016-01-01
Stable and low-cost multiplexed drug sensitivity assays using small volumes of cells or tissue are in demand for personalized medicine, including patientspecific combination chemotherapy. Spatially defined projected light photopolymerization of hydrogels with embedded active compounds is introduc...
Distributed Weighted Parameter Averaging for SVM Training on Big Data
Das, Ayan; Bhattacharya, Sourangshu
2015-01-01
Two popular approaches for distributed training of SVMs on big data are parameter averaging and ADMM. Parameter averaging is efficient but suffers from loss of accuracy with increase in number of partitions, while ADMM in the feature space is accurate but suffers from slow convergence. In this paper, we report a hybrid approach called weighted parameter averaging (WPA), which optimizes the regularized hinge loss with respect to weights on parameters. The problem is shown to be same as solving...
On the average crosscap number Ⅱ: Bounds for a graph
Institute of Scientific and Technical Information of China (English)
Yi-chao CHEN; Yan-pei LIU
2007-01-01
The bounds are obtained for the average crosscap number. Let G be a graph which is not a tree. It is shown that the average crosscap number of G is not less than 2β(G)-1/2β(G)-1β(G)β(G) and not larger than/β(G). Furthermore, we also describe the structure of the graphs which attain the bounds of the average crosscap number.
On the average crosscap number II: Bounds for a graph
Institute of Scientific and Technical Information of China (English)
2007-01-01
The bounds are obtained for the average crosscap number. Let G be a graph which is not a tree. It is shown that the average crosscap number of G is not less thanβ(G)-1/2β(G)-1β(G) and not larger thanβ(G). Furthermore, we also describe the structure of the graphs which attain the bounds of the average crosscap number.
SPATIAL DISTRIBUTION OF THE AVERAGE RUNOFF IN THE IZA AND VIȘEU WATERSHEDS
Directory of Open Access Journals (Sweden)
HORVÁTH CS.
2015-03-01
Full Text Available The average runoff represents the main parameter with which one can best evaluate an area’s water resources and it is also an important characteristic in al river runoff research. In this paper we choose a GIS methodology for assessing the spatial evolution of the average runoff, using validity curves we identifies three validity areas in which the runoff changes differently with altitude. The tree curves were charted using the average runoff values of 16 hydrometric stations from the area, eight in the Vișeu and eight in the Iza river catchment. Identifying the appropriate areas of the obtained correlations curves (between specific average runoff and catchments mean altitude allowed the assessment of potential runoff at catchment level and on altitudinal intervals. By integrating the curves functions in to GIS we created an average runoff map for the area; from which one can easily extract runoff data using GIS spatial analyst functions. The study shows that from the three areas the highest runoff corresponds with the third zone but because it’s small area the water volume is also minor. It is also shown that with the use of the created runoff map we can compute relatively quickly correct runoff values for areas without hydrologic control.
Decision trees with minimum average depth for sorting eight elements
AbouEisha, Hassan
2015-11-19
We prove that the minimum average depth of a decision tree for sorting 8 pairwise different elements is equal to 620160/8!. We show also that each decision tree for sorting 8 elements, which has minimum average depth (the number of such trees is approximately equal to 8.548×10^326365), has also minimum depth. Both problems were considered by Knuth (1998). To obtain these results, we use tools based on extensions of dynamic programming which allow us to make sequential optimization of decision trees relative to depth and average depth, and to count the number of decision trees with minimum average depth.
Practical definition of averages of tensors in general relativity
Boero, Ezequiel F
2016-01-01
We present a definition of tensor fields which are average of tensors over a manifold, with a straightforward and natural definition of derivative for the averaged fields; which in turn makes a suitable and practical construction for the study of averages of tensor fields that satisfy differential equations. Although we have in mind applications to general relativity, our presentation is applicable to a general n-dimensional manifold. The definition is based on the integration of scalars constructed from a physically motivated basis, making use of the least amount of geometrical structure. We also present definitions of covariant derivative of the averaged tensors and Lie derivative.
Herbal drugs and drug interactions
Gül Dülger
2014-01-01
Herbal drugs are defined as any form of a plant or plant product that contains a single herb or combinations of herbs that are believed to have complementary effects. Although they are considered to be safe, because they are natural, they may have various adverse effects, and may interact with other herbal products or conventional drugs. These interactions are especially important for drugs with narrow therapeutic indices.In the present study, pharmacokinetic and pharmacodynamic interactions ...
... Age Adults in 2015 Teens and E-cigarettes Abuse of Prescription (Rx) Drugs Affects Young Adults Most Substance Use in Women and Men View All NIDA's Publication Series Brain Power DrugFacts Mind Over Matter Research Reports NIDA Home ...
Institute of Scientific and Technical Information of China (English)
2010-01-01
2010263 Drug resistance mechanism of non-small cell lung cancer PC9/AB2 cell line with acquired drug resistance to gefitinib.JU Lixia(鞠立霞),et al. Dept Oncol,Shanghai Pulm Hosp,Tongji Univ,Shanghai 200433. Chin J Tuberc Respir Dis 2010;33(5):354-358. Objective To
Sardana, Raj K.
This autoinstructional lesson deals with the study of such drugs as marijuana and LSD, with emphasis on drug abuse. It is suggested that it can be used in science classes at the middle level of school. No prerequisites are suggested. The teacher's guide lists the behavioral objectives, the equipment needed to complete the experience and suggests…
Ovarian volume throughout life
DEFF Research Database (Denmark)
Kelsey, Thomas W; Dodwell, Sarah K; Wilkinson, A Graham
2013-01-01
cancer. To date there is no normative model of ovarian volume throughout life. By searching the published literature for ovarian volume in healthy females, and using our own data from multiple sources (combined n=59,994) we have generated and robustly validated the first model of ovarian volume from...... to about 2.8 mL (95% CI 2.7-2.9 mL) at the menopause and smaller volumes thereafter. Our model allows us to generate normal values and ranges for ovarian volume throughout life. This is the first validated normative model of ovarian volume from conception to old age; it will be of use in the diagnosis...
African Journals Online (AJOL)
minor and intermediate surgical procedures in regions where there is a dearth of anesthetists. Its unique ... The Nigerian Journal of Surgical Research Volume 3 Number 3-4 December 2001 ... dangers of this general anaesthetic agent.
Disc volume reduction with percutaneous nucleoplasty in an animal model.
Directory of Open Access Journals (Sweden)
Richard Kasch
Full Text Available STUDY DESIGN: We assessed volume following nucleoplasty disc decompression in lower lumbar spines from cadaveric pigs using 7.1Tesla magnetic resonance imaging (MRI. PURPOSE: To investigate coblation-induced volume reductions as a possible mechanism underlying nucleoplasty. METHODS: We assessed volume following nucleoplastic disc decompression in pig spines using 7.1-Tesla MRI. Volumetry was performed in lumbar discs of 21 postmortem pigs. A preoperative image data set was obtained, volume was determined, and either disc decompression or placebo therapy was performed in a randomized manner. Group 1 (nucleoplasty group was treated according to the usual nucleoplasty protocol with coblation current applied to 6 channels for 10 seconds each in an application field of 360°; in group 2 (placebo group the same procedure was performed but without coblation current. After the procedure, a second data set was generated and volumes calculated and matched with the preoperative measurements in a blinded manner. To analyze the effectiveness of nucleoplasty, volumes between treatment and placebo groups were compared. RESULTS: The average preoperative nucleus volume was 0.994 ml (SD: 0.298 ml. In the nucleoplasty group (n = 21 volume was reduced by an average of 0.087 ml (SD: 0.110 ml or 7.14%. In the placebo group (n = 21 volume was increased by an average of 0.075 ml (SD: 0.075 ml or 8.94%. The average nucleoplasty-induced volume reduction was 0.162 ml (SD: 0.124 ml or 16.08%. Volume reduction in lumbar discs was significant in favor of the nucleoplasty group (p<0.0001. CONCLUSIONS: Our study demonstrates that nucleoplasty has a volume-reducing effect on the lumbar nucleus pulposus in an animal model. Furthermore, we show the volume reduction to be a coblation effect of nucleoplasty in porcine discs.
Parameterization of small intestinal water volume using PBPK modeling.
Maharaj, Anil; Fotaki, Nikoletta; Edginton, Andrea
2015-01-25
To facilitate accurate predictions of oral drug disposition, mechanistic absorption models require optimal parameterization. Furthermore, parameters should maintain a biological basis to establish confidence in model predictions. This study will serve to calculate an optimal parameter value for small intestinal water volume (SIWV) using a model-based approach. To evaluate physiologic fidelity, derived volume estimates will be compared to experimentally-based SIWV determinations. A compartmental absorption and transit (CAT) model, created in Matlab-Simulink®, was integrated with a whole-body PBPK model, developed in PK-SIM 5.2®, to provide predictions of systemic drug disposition. SIWV within the CAT model was varied between 52.5mL and 420mL. Simulations incorporating specific SIWV values were compared to pharmacokinetic data from compounds exhibiting solubility induced non-proportional changes in absorption using absolute average fold-error. Correspondingly, data pertaining to oral administration of acyclovir and chlorothiazide were utilized to derive estimates of SIWV. At 400mg, a SIWV of 116mL provided the best estimates of acyclovir plasma concentrations. A similar SIWV was found to best depict the urinary excretion pattern of chlorothiazide at a dose of 100mg. In comparison, experimentally-based estimates of SIWV within adults denote a central tendency between 86 and 167mL. The derived SIWV (116mL) represents the optimal parameter value within the context of the developed CAT model. This result demonstrates the biological basis of the widely utilized CAT model as in vivo SIWV determinations correspond with model-based estimates.
The average visual response in patients with cerebrovascular disease
Oostehuis, H.J.G.H.; Ponsen, E.J.; Jonkman, E.J.; Magnus, O.
1969-01-01
The average visual response (AVR) was recorded in thirty patients after a cerebrovascular accident and in fourteen control subjects from the same age group. The AVR was obtained with the aid of a 16-channel EEG machine, a Computer of Average Transients and a tape recorder with 13 FM channels. This
Charging for computer usage with average cost pricing
Landau, K
1973-01-01
This preliminary report, which is mainly directed to commercial computer centres, gives an introduction to the application of average cost pricing when charging for using computer resources. A description of the cost structure of a computer installation shows advantages and disadvantages of average cost pricing. This is completed by a discussion of the different charging-rates which are possible. (10 refs).
On the Average-Case Complexity of Shellsort
Vitányi, P.M.B.
2015-01-01
We prove a lower bound expressed in the increment sequence on the average-case complexity (number of inversions which is proportional to the running time) of Shellsort. This lower bound is sharp in every case where it could be checked. We obtain new results e.g. determining the average-case complexi
Interpreting Bivariate Regression Coefficients: Going beyond the Average
Halcoussis, Dennis; Phillips, G. Michael
2010-01-01
Statistics, econometrics, investment analysis, and data analysis classes often review the calculation of several types of averages, including the arithmetic mean, geometric mean, harmonic mean, and various weighted averages. This note shows how each of these can be computed using a basic regression framework. By recognizing when a regression model…
Analytic computation of average energy of neutrons inducing fission
Energy Technology Data Exchange (ETDEWEB)
Clark, Alexander Rich [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
2016-08-12
The objective of this report is to describe how I analytically computed the average energy of neutrons that induce fission in the bare BeRP ball. The motivation of this report is to resolve a discrepancy between the average energy computed via the FMULT and F4/FM cards in MCNP6 by comparison to the analytic results.
Safety Impact of Average Speed Control in the UK
DEFF Research Database (Denmark)
Lahrmann, Harry Spaabæk; Brassøe, Bo; Johansen, Jonas Wibert
2016-01-01
in the UK. The study demonstrates that the introduction of average speed control results in statistically significant and substantial reductions both in speed and in number of accidents. The evaluation indicates that average speed control has a higher safety effect than point-based automatic speed control....
A Statistical Mechanics Approach to Approximate Analytical Bootstrap Averages
DEFF Research Database (Denmark)
Malzahn, Dorthe; Opper, Manfred
2003-01-01
We apply the replica method of Statistical Physics combined with a variational method to the approximate analytical computation of bootstrap averages for estimating the generalization error. We demonstrate our approach on regression with Gaussian processes and compare our results with averages...
A Simple Geometrical Derivation of the Spatial Averaging Theorem.
Whitaker, Stephen
1985-01-01
The connection between single phase transport phenomena and multiphase transport phenomena is easily accomplished by means of the spatial averaging theorem. Although different routes to the theorem have been used, this paper provides a route to the averaging theorem that can be used in undergraduate classes. (JN)
Averaged EMG profiles in jogging and running at different speeds
Gazendam, Marnix G. J.; Hof, At L.
2007-01-01
EMGs were collected from 14 muscles with surface electrodes in 10 subjects walking 1.25-2.25 m s(-1) and running 1.25-4.5 m s(-1). The EMGs were rectified, interpolated in 100% of the stride, and averaged over all subjects to give an average profile. In running, these profiles could be decomposed in
Average widths of anisotropic Besov-Wiener classes
Institute of Scientific and Technical Information of China (English)
无
2000-01-01
This paper concerns the problem of average σ-K width and average σ-L width of some anisotropic Besov-Wiener classes Srp q θb(Rd) and Srp q θB(Rd) in Lq(Rd) (1≤q≤p＜∞). The weak asymptotic behavior is established for the corresponding quantities.
7 CFR 701.17 - Average adjusted gross income limitation.
2010-01-01
... 9003), each applicant must meet the provisions of the Adjusted Gross Income Limitations at 7 CFR part... 7 Agriculture 7 2010-01-01 2010-01-01 false Average adjusted gross income limitation. 701.17... RELATED PROGRAMS PREVIOUSLY ADMINISTERED UNDER THIS PART § 701.17 Average adjusted gross income...
A note on moving average models for Gaussian random fields
DEFF Research Database (Denmark)
Hansen, Linda Vadgård; Thorarinsdottir, Thordis L.
The class of moving average models offers a flexible modeling framework for Gaussian random fields with many well known models such as the Matérn covariance family and the Gaussian covariance falling under this framework. Moving average models may also be viewed as a kernel smoothing of a Lévy...
(Average-) convexity of common pool and oligopoly TU-games
Driessen, T.S.H.; Meinhardt, H.
2000-01-01
The paper studies both the convexity and average-convexity properties for a particular class of cooperative TU-games called common pool games. The common pool situation involves a cost function as well as a (weakly decreasing) average joint production function. Firstly, it is shown that, if the rele
Average widths of anisotropic Besov-Wiener classes
Institute of Scientific and Technical Information of China (English)
蒋艳杰
2000-01-01
This paper concems the problem of average σ-K width and average σ-L width of some anisotropic Besov-wiener classes Spqθr(Rd) and Spqθr(Rd) in Lq(Rd) (1≤≤q≤p<∞). The weak asymptotic behavior is established for the corresponding quantities.
Remarks on the Lower Bounds for the Average Genus
Institute of Scientific and Technical Information of China (English)
Yi-chao Chen
2011-01-01
Let G be a graph of maximum degree at most four. By using the overlap matrix method which is introduced by B. Mohar, we show that the average genus of G is not less than 1/3 of its maximum genus, and the bound is best possible. Also, a new lower bound of average genus in terms of girth is derived.
Delineating the Average Rate of Change in Longitudinal Models
Kelley, Ken; Maxwell, Scott E.
2008-01-01
The average rate of change is a concept that has been misunderstood in the literature. This article attempts to clarify the concept and show unequivocally the mathematical definition and meaning of the average rate of change in longitudinal models. The slope from the straight-line change model has at times been interpreted as if it were always the…
Time-dependent density functional theory with twist-averaged boundary conditions
Schuetrumpf, B; Reinhard, P -G
2016-01-01
Time-dependent density functional theory is widely used to describe excitations of many-fermion systems. In its many applications, 3D coordinate-space representation is used, and infinite-domain calculations are limited to a finite volume represented by a box. For finite quantum systems (atoms, molecules, nuclei), the commonly used periodic or reflecting boundary conditions introduce spurious quantization of the continuum states and artificial reflections from boundary; hence, an incorrect treatment of evaporated particles. These artifacts can be practically cured by introducing absorbing boundary conditions (ABC) through an absorbing potential in a certain boundary region sufficiently far from the described system. But also the calculations of infinite matter (crystal electrons, quantum fluids, neutron star crust) suffer artifacts from a finite computational box. In this regime, twist- averaged boundary conditions (TABC) have been used successfully to diminish the finite-volume effects. In this work, we exte...
Average cross-responses in correlated financial markets
Wang, Shanshan; Schäfer, Rudi; Guhr, Thomas
2016-09-01
There are non-vanishing price responses across different stocks in correlated financial markets, reflecting non-Markovian features. We further study this issue by performing different averages, which identify active and passive cross-responses. The two average cross-responses show different characteristic dependences on the time lag. The passive cross-response exhibits a shorter response period with sizeable volatilities, while the corresponding period for the active cross-response is longer. The average cross-responses for a given stock are evaluated either with respect to the whole market or to different sectors. Using the response strength, the influences of individual stocks are identified and discussed. Moreover, the various cross-responses as well as the average cross-responses are compared with the self-responses. In contrast to the short-memory trade sign cross-correlations for each pair of stocks, the sign cross-correlations averaged over different pairs of stocks show long memory.
The Optimal Selection for Restricted Linear Models with Average Estimator
Directory of Open Access Journals (Sweden)
Qichang Xie
2014-01-01
Full Text Available The essential task of risk investment is to select an optimal tracking portfolio among various portfolios. Statistically, this process can be achieved by choosing an optimal restricted linear model. This paper develops a statistical procedure to do this, based on selecting appropriate weights for averaging approximately restricted models. The method of weighted average least squares is adopted to estimate the approximately restricted models under dependent error setting. The optimal weights are selected by minimizing a k-class generalized information criterion (k-GIC, which is an estimate of the average squared error from the model average fit. This model selection procedure is shown to be asymptotically optimal in the sense of obtaining the lowest possible average squared error. Monte Carlo simulations illustrate that the suggested method has comparable efficiency to some alternative model selection techniques.
Do Diurnal Aerosol Changes Affect Daily Average Radiative Forcing?
Energy Technology Data Exchange (ETDEWEB)
Kassianov, Evgueni I.; Barnard, James C.; Pekour, Mikhail S.; Berg, Larry K.; Michalsky, Joseph J.; Lantz, K.; Hodges, G. B.
2013-06-17
Strong diurnal variability of aerosol has been observed frequently for many urban/industrial regions. How this variability may alter the direct aerosol radiative forcing (DARF), however, is largely unknown. To quantify changes in the time-averaged DARF, we perform an assessment of 29 days of high temporal resolution ground-based data collected during the Two-Column Aerosol Project (TCAP) on Cape Cod, which is downwind of metropolitan areas. We demonstrate that strong diurnal changes of aerosol loading (about 20% on average) have a negligible impact on the 24-h average DARF, when daily averaged optical properties are used to find this quantity. However, when there is a sparse temporal sampling of aerosol properties, which may preclude the calculation of daily averaged optical properties, large errors (up to 100%) in the computed DARF may occur. We describe a simple way of reducing these errors, which suggests the minimal temporal sampling needed to accurately find the forcing.
Calderer, M Carme; Siegel, Ronald A; Yao, Lingxing
2015-01-01
We present modeling, analysis and numerical simulation of a prototype glucose driven drug delivery device based on chemomechanical interactions and volume phase transitions in polyelectrolyte gels. The device consists of two fluid compartments, an external cell (I) mimicking the physiological environment, and a closed chamber (II), separated by a hydrogel membrane. Cell I, which is held at constant pH and ionic strength, provides a constant supply of glucose to cell II, and also serves as clearance station for reaction products. Cell II contains the drug to be delivered to the body, an enzyme that catalyzes conversion of glucose into hydrogen ions, and a piece of marble to remove excess hydrogen ions that would otherwise overwhelm the system. When the membrane is swollen, glucose flux into Cell II is high, leading to rapid production of hydrogen ions. However, the hydrogen ions are not immediately released to Cell I but react, instead, with the negatively charged carboxyl groups of the membrane, which collaps...
Adolescence in New Zealand. Volume Two: Wider Perspectives.
Stewart, Robert A. C., Ed.
This is the second of a two-volume collection of research-based readings dealing with the New Zealand adolescent. This volume considers the areas of drugs and delinquency, as well as the world of work and Maori-pakeha differences. The following topics are included: marihuana use; vocational aspiration; alcohol and tobacco use; Maori-pakeha…
Commercial importation of prescription drugs in the United States: short-run implications.
Danzon, Patricia M; Johnson, Scott J; Long, Genia; Furukawa, Michael F
2011-04-01
The option of legalizing the commercial importation of prescription drugs is of continued policy interest as a way to reduce U.S. drug spending. Using IMS data, we estimate potential savings from commercial drug importation under assumptions about percentage of drugs likely to attract imports; potential supply from foreign countries; and share of savings passed on to payers. Our base case estimate is that $1.7 billion per year, or 0.6 percent of total drug spending, would be saved by payers; sensitivity analyses range from 0.2 to 2.5 percent under plausible assumptions and up to 17.4 percent under unrealistic assumptions about unlimited foreign supply, costless trade, and zero profits for intermediaries. Estimated savings to payers are less than the average price differentials between the United States and foreign countries because proposed legislation exempts certain drugs from importation; foreign markets are small relative to the United States; regulatory and other constraints may limit the volume of exports; trade is costly; and intermediaries will retain some savings. Although savings to U.S. payers/consumers would likely be small and have minimal impact on total U.S. health care spending, costs to other countries could be significant, due to reduced access and possibly higher prices. In the long run, reduced investment in R&D could adversely affect consumers globally.
Ferguson, Patricia, Ed.; And Others
The National Institute on Drug Abuse presents this report as the fifth in a series intended to summarize the empirical research findings and major theoretical approaches relating to the the issues of drug use and abuse. Included in this volume are summaries of the major research findings concerning the effects of nonmedical drug use on pregnancy.…
DEFF Research Database (Denmark)
Mogensen, O.; Sørensen, Flemming Brandt; Bichel, P.
1999-01-01
We evaluated the following nine parameters with respect to their prognostic value in females with endometrial cancer: four stereologic parameters [mean nuclear volume (MNV), nuclear volume fraction, nuclear index and mitotic index], the immunohistochemical expression of cancer antigen (CA125...
APPLICATION OF FDS SCHEME TO 2D DEPTH-AVERAGED FLOW-POLLUTANTS SIMULATION
Institute of Scientific and Technical Information of China (English)
Zhang Li-qiong; Zhao Di-hua; Lai Jihn-sung; Yao Qi; Xiao Jun-ying
2003-01-01
A Fulx Difference Splitting (FDS) scheme was used in a 2D depth-averaged flow-pollutant model. Within the framework of the Finite Volume Method (FVM) a 2D simulation was transferred into solving a series of local 1D problems based on the rotational invariance property of the flux. The FDS scheme was employed to estimate the normal numerical flux of variables including water mass, momentum and pollutant concentration across the interface between cells. The scheme was checked with exact solutions and verified by observations in the Nantong reach of the Yangtze River. Calculated results well match both exact solutions and observations.
Non-chain pulsed DF laser with an average power of the order of 100 W
Pan, Qikun; Xie, Jijiang; Wang, Chunrui; Shao, Chunlei; Shao, Mingzhen; Chen, Fei; Guo, Jin
2016-07-01
The design and performance of a closed-cycle repetitively pulsed DF laser are described. The Fitch circuit and thyratron switch are introduced to realize self-sustained volume discharge in SF6-D2 mixtures. The influences of gas parameters and charging voltage on output characteristics of non-chain pulsed DF laser are experimentally investigated. In order to improve the laser power stability over a long period of working time, zeolites with different apertures are used to scrub out the de-excitation particles produced in electric discharge. An average output power of the order of 100 W was obtained at an operating repetition rate of 50 Hz, with amplitude difference in laser pulses <8 %. And under the action of micropore alkaline zeolites, the average power fell by 20 % after the laser continuing working 100 s at repetition frequency of 50 Hz.
Exploring the Best Classification from Average Feature Combination
Directory of Open Access Journals (Sweden)
Jian Hou
2014-01-01
Full Text Available Feature combination is a powerful approach to improve object classification performance. While various combination algorithms have been proposed, average combination is almost always selected as the baseline algorithm to be compared with. In previous work we have found that it is better to use only a sample of the most powerful features in average combination than using all. In this paper, we continue this work and further show that the behaviors of features in average combination can be integrated into the k-Nearest-Neighbor (kNN framework. Based on the kNN framework, we then propose to use a selection based average combination algorithm to obtain the best classification performance from average combination. Our experiments on four diverse datasets indicate that this selection based average combination performs evidently better than the ordinary average combination, and thus serves as a better baseline. Comparing with this new and better baseline makes the claimed superiority of newly proposed combination algorithms more convincing. Furthermore, the kNN framework is helpful in understanding the underlying mechanism of feature combination and motivating novel feature combination algorithms.
Bounds on Average Time Complexity of Decision Trees
Chikalov, Igor
2011-01-01
In this chapter, bounds on the average depth and the average weighted depth of decision trees are considered. Similar problems are studied in search theory [1], coding theory [77], design and analysis of algorithms (e.g., sorting) [38]. For any diagnostic problem, the minimum average depth of decision tree is bounded from below by the entropy of probability distribution (with a multiplier 1/log2 k for a problem over a k-valued information system). Among diagnostic problems, the problems with a complete set of attributes have the lowest minimum average depth of decision trees (e.g, the problem of building optimal prefix code [1] and a blood test study in assumption that exactly one patient is ill [23]). For such problems, the minimum average depth of decision tree exceeds the lower bound by at most one. The minimum average depth reaches the maximum on the problems in which each attribute is "indispensable" [44] (e.g., a diagnostic problem with n attributes and kn pairwise different rows in the decision table and the problem of implementing the modulo 2 summation function). These problems have the minimum average depth of decision tree equal to the number of attributes in the problem description. © Springer-Verlag Berlin Heidelberg 2011.
Energy Technology Data Exchange (ETDEWEB)
Xu, Yanhui [The Institute of Electrochemical Power Sources, Soochow University, Moye Road 688, Suzhou 215006 (China); Ju, Hua [School of Urban Rail Transportation, Soochow University, Ganjiang East Road 178, Suzhou 215021 (China)
2009-02-15
It is just the best time to compile and compare the experimental data and to explore the possible laws and to discover the relation between the crystallographic parameters, thermodynamic and electrochemical properties, based on lot of the published experimental data about the hydrogen-storage alloys. An empirical correlation between the unit cell volume and the enthalpy change, equilibrium pressure, discharge capacity has been constructed. The violent change of the equilibrium pressure with the unit cell volume might indicate the change in the interaction nature between the host alloy atoms and the intercalated hydrogen atoms. The dependence of unit cell volume vs. average numbers of total electrons for AB{sub 5}-type alloys exhibits same change tendency as that of the Vanderwaals radius vs. atomic numbers from Fe to Se in the elements' periodic table. It is possible that the total numbers of the electrons decides the unit cell volume. (author)
Drugs used in child maltreatment.
2011-10-01
Between 2000 and 2008, the American Association of Poison Control Centers recorded 1439 cases in which drugs or alcohol were used to mistreat children under 7 years of age, representing an average of 160 reports per year. Median age was 2 years, and 57% of victims were boys. The substances included psychotropic drugs, analgesics, cold remedies, alcohol, and illicit drugs. 18 children died, while 32 children experienced life-threatening effects or residual disability. It is not clear whether these results can be extrapolated to the French population. In France, a yearly survey of the Centres for Evaluation and Information on Pharmacodependence (CEIP) identified 162 cases of "chemical submission", 3 of which involved children. In practice, it is often difficult to recognise when a child is being maltreated, especially when medications, illicit drugs or alcohol are used. Taking into consideration the known adverse effect profile of a drug may provide a clue, help to limit harms to the child and allow appropriate management.
Unbiased Cultural Transmission in Time-Averaged Archaeological Assemblages
Madsen, Mark E
2012-01-01
Unbiased models are foundational in the archaeological study of cultural transmission. Applications have as- sumed that archaeological data represent synchronic samples, despite the accretional nature of the archaeological record. I document the circumstances under which time-averaging alters the distribution of model predictions. Richness is inflated in long-duration assemblages, and evenness is "flattened" compared to unaveraged samples. Tests of neutrality, employed to differentiate biased and unbiased models, suffer serious problems with Type I error under time-averaging. Finally, the time-scale over which time-averaging alters predictions is determined by the mean trait lifetime, providing a way to evaluate the impact of these effects upon archaeological samples.
Average-Case Analysis of Algorithms Using Kolmogorov Complexity
Institute of Scientific and Technical Information of China (English)
姜涛; 李明
2000-01-01
Analyzing the average-case complexity of algorithms is a very prac tical but very difficult problem in computer science. In the past few years, we have demonstrated that Kolmogorov complexity is an important tool for analyzing the average-case complexity of algorithms. We have developed the incompressibility method. In this paper, several simple examples are used to further demonstrate the power and simplicity of such method. We prove bounds on the average-case number of stacks (queues) required for sorting sequential or parallel Queuesort or Stacksort.
Sample Selected Averaging Method for Analyzing the Event Related Potential
Taguchi, Akira; Ono, Youhei; Kimura, Tomoaki
The event related potential (ERP) is often measured through the oddball task. On the oddball task, subjects are given “rare stimulus” and “frequent stimulus”. Measured ERPs were analyzed by the averaging technique. In the results, amplitude of the ERP P300 becomes large when the “rare stimulus” is given. However, measured ERPs are included samples without an original feature of ERP. Thus, it is necessary to reject unsuitable measured ERPs when using the averaging technique. In this paper, we propose the rejection method for unsuitable measured ERPs for the averaging technique. Moreover, we combine the proposed method and Woody's adaptive filter method.
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Full Text Available ... Link Between Drug Use and HIV/AIDS Treatment & Recovery What is Treatment? Why Does a Person Need ... Work? What Are the Treatment Options? What Is Recovery? What Is a Relapse? How Can Friends and ...
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De Clercq, Erik
2010-10-01
In October 2010, it will be exactly 25 years ago that the first antiretroviral drug, AZT (zidovudine, 3'-azido-2',3'-dideoxythymidine), was described. It was the first of 25 antiretroviral drugs that in the past 25 years have been formally licensed for clinical use. These antiretroviral drugs fall into seven categories [nucleoside reverse transcriptase inhibitors (NRTIs), nucleotide reverse transcriptase inhibitors (NtRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), fusion inhibitors (FIs), co-receptor inhibitors (CRIs) and integrase inhibitors (INIs). The INIs (i.e. raltegravir) represent the most recent advance in the search for effective and selective anti-HIV agents. Combination of several anti-HIV drugs [often referred to as highly active antiretroviral therapy (HAART)] has drastically altered AIDS from an almost uniformly fatal disease to a chronic manageable one.
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Full Text Available ... Ecstasy, Molly) Facts Meth (Crank, Ice) Facts Pain Medicine (Oxy, Vike) Facts Spice (K2) Facts Tobacco and ... Bath Salts Cocaine Heroin Marijuana MDMA Meth Pain Medicines Spice (K2) Tobacco/Nicotine Other Drugs You can ...
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Directory of Open Access Journals (Sweden)
Tao WANG
2010-12-01
Full Text Available Isotopic fractionation is the foundation of tracing water cycle using hydrogen and oxygen isotopes. Isotopic fractionation factors in evaporation from free water body are mainly affected by temperature and relative humidity, and greatly vary with these atmospheric factors in a day. Evaporation rate can properly reveal the effects of atmospheric factors. Therefore, there should be a certain function relationship existing in isotopic fractionation factors and evaporation rate. An average isotopic fractionation factor was defined to describe isotopic differences between vapor and liquid phases in evaporation with time interval of hours or days. The relationship of average isotopic fractionation factor and evaporation based on isotopic mass balance was investigated through an evaporation pan experiment with no inflow. The experimental results showed that the isotopic compositions of residual water became more enrichment with time; the average isotopic fractionation factor was affected by air temperature, relative humidity and other atmospheric factors, and had a good functional relation with evaporation rate. The values of average isotopic fractionation factor could be easily calculated with the known of evaporation rate, the initial volume of water in pan and isotopic compositions of residual water.
Energy Technology Data Exchange (ETDEWEB)
Sabin, Charles; Plevka, Pavel, E-mail: pavel.plevka@ceitec.muni.cz [Central European Institute of Technology – Masaryk University, Kamenice 653/25, 625 00 Brno (Czech Republic)
2016-02-16
Molecular replacement and noncrystallographic symmetry averaging were used to detwin a data set affected by perfect hemihedral twinning. The noncrystallographic symmetry averaging of the electron-density map corrected errors in the detwinning introduced by the differences between the molecular-replacement model and the crystallized structure. Hemihedral twinning is a crystal-growth anomaly in which a specimen is composed of two crystal domains that coincide with each other in three dimensions. However, the orientations of the crystal lattices in the two domains differ in a specific way. In diffraction data collected from hemihedrally twinned crystals, each observed intensity contains contributions from both of the domains. With perfect hemihedral twinning, the two domains have the same volumes and the observed intensities do not contain sufficient information to detwin the data. Here, the use of molecular replacement and of noncrystallographic symmetry (NCS) averaging to detwin a 2.1 Å resolution data set for Aichi virus 1 affected by perfect hemihedral twinning is described. The NCS averaging enabled the correction of errors in the detwinning introduced by the differences between the molecular-replacement model and the crystallized structure. The procedure permitted the structure to be determined from a molecular-replacement model that had 16% sequence identity and a 1.6 Å r.m.s.d. for C{sup α} atoms in comparison to the crystallized structure. The same approach could be used to solve other data sets affected by perfect hemihedral twinning from crystals with NCS.
SU-D-201-04: Study On the Impact of Tumor Shape and Size On Drug Delivery to Pancreatic Tumors
Energy Technology Data Exchange (ETDEWEB)
Soltani, M [ohns Hopkins University School of Medicine, Baltimore, Maryland, and KNT university, Tehran (Iran, Islamic Republic of); Bazmara, H [KNT university, Tehran (Iran, Islamic Republic of); Sefidgar, M [IKI University, Qazvin (Iran, Islamic Republic of); Subramaniam, R; Rahmim, A [Johns Hopkins University School of Medicine, Baltimore, MD (United States)
2015-06-15
Purpose: Drug delivery to solid tumors can be expressed physically using transport phenomena such as convection and diffusion for the drug of interest within extracellular matrices. We aimed to carefully model these phenomena, and to investigate the effect of tumor shape and size on drug delivery to solid tumors in the pancreas. Methods: In this study, multiple tumor geometries as obtained from clinical PET/CT images were considered. An advanced numerical method was used to simultaneously solve fluid flow and solute transport equations. Data from n=45 pancreatic cancer patients with non-resectable locoregional disease were analyzed, and geometrical information from the tumors including size, shape, and aspect ratios were classified. To investigate effect of tumor shape, tumors with similar size but different shapes were selected and analyzed. Moreover, to investigate effect of tumor size, tumors with similar shapes but different sizes, ranging from 1 to 77 cm{sup 3}, were selected and analyzed. A hypothetical tumor similar to one of the analyzed tumors, but scaled to reduce its size below 0.2 cm{sup 3}, was also analyzed. Results: The results showed relatively similar average drug concentration profiles in tumors with different sizes. Generally, smaller tumors had higher absolute drug concentration. In the hypothetical tumor, with volume less than 0.2 cm{sup 3}, the average drug concentration was 20% higher in comparison to its counterparts. For the various real tumor geometries, however, the maximum difference between average drug concentrations was 10% for the smallest and largest tumors. Moreover, the results demonstrated that for pancreatic tumors the shape is not significant. The negligible difference of drug concentration in different tumor shapes was due to the minimum effect of convection in pancreatic tumors. Conclusion: In tumors with different sizes, smaller tumors have higher drug delivery; however, the impact of tumor shape in the case of pancreatic
Drug-drug interactions: antiretroviral drugs and recreational drugs.
Staltari, Orietta; Leporini, Christian; Caroleo, Benedetto; Russo, Emilio; Siniscalchi, Antonio; De Sarro, Giovambattista; Gallelli, Luca
2014-01-01
With the advances in antiretroviral (ARV) therapy, patients with Human Immunodeficiency Virus (HIV) infection are living longer, however, some patients encounter co- morbidities which sometimes require treatment. Therefore, during the treatment with ARV drugs these patients could take several recreational drugs (e.g. amphetamines, hallucinogenes, opiates, or alcohol) with a possible development of drug-drug interactions (DDIs). In particular, Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs/NtRTIs) are mainly excreted through the kidney and are not substrates of the cytochrome P450 or P-glycoprotein, therefore the DDIs during this treatment are minimal. In contrast, the other ARV drugs (i.e. non-nucleoside reversetranscriptase inhibitors, Protease inhibitors, Integrase inhibitors, chemokine receptor 5 antagonists and HIV-fusion inhibitors) are an important class of antiretroviral medications that are frequent components of HAART regimens but show several DDIs related to interaction with the cytochrome P450 or P-glycoprotein. In this paper we will review data concerning the possibility of DDI in HIV patients treated with ARV and taking recreational drugs.
Grade-Average Method: A Statistical Approach for Estimating ...
African Journals Online (AJOL)
Grade-Average Method: A Statistical Approach for Estimating Missing Value for Continuous Assessment Marks. ... Journal of the Nigerian Association of Mathematical Physics. Journal Home · ABOUT ... Open Access DOWNLOAD FULL TEXT ...
United States Average Annual Precipitation, 2000-2004 - Direct Download
U.S. Geological Survey, Department of the Interior — This map layer shows polygons of average annual precipitation in the contiguous United States, for the climatological period 2000-2004. Parameter-elevation...
On the average sensitivity of laced Boolean functions
jiyou, Li
2011-01-01
In this paper we obtain the average sensitivity of the laced Boolean functions. This confirms a conjecture of Shparlinski. We also compute the weights of the laced Boolean functions and show that they are almost balanced.
Distribution of population-averaged observables in stochastic gene expression
Bhattacharyya, Bhaswati; Kalay, Ziya
2014-01-01
Observation of phenotypic diversity in a population of genetically identical cells is often linked to the stochastic nature of chemical reactions involved in gene regulatory networks. We investigate the distribution of population-averaged gene expression levels as a function of population, or sample, size for several stochastic gene expression models to find out to what extent population-averaged quantities reflect the underlying mechanism of gene expression. We consider three basic gene regulation networks corresponding to transcription with and without gene state switching and translation. Using analytical expressions for the probability generating function of observables and large deviation theory, we calculate the distribution and first two moments of the population-averaged mRNA and protein levels as a function of model parameters, population size, and number of measurements contained in a data set. We validate our results using stochastic simulations also report exact results on the asymptotic properties of population averages which show qualitative differences among different models.
on the performance of Autoregressive Moving Average Polynomial ...
African Journals Online (AJOL)
Timothy Ademakinwa
Moving Average Polynomial Distributed Lag (ARMAPDL) model. The parameters of these models were estimated using least squares and Newton Raphson iterative methods. ..... Global Journal of Mathematics and Statistics. Vol. 1. No.
The Partial Averaging of Fuzzy Differential Inclusions on Finite Interval
Directory of Open Access Journals (Sweden)
Andrej V. Plotnikov
2014-01-01
Full Text Available The substantiation of a possibility of application of partial averaging method on finite interval for differential inclusions with the fuzzy right-hand side with a small parameter is considered.
United States Average Annual Precipitation, 2005-2009 - Direct Download
U.S. Geological Survey, Department of the Interior — This map layer shows polygons of average annual precipitation in the contiguous United States, for the climatological period 2005-2009. Parameter-elevation...
SAM: A Simple Averaging Model of Impression Formation
Lewis, Robert A.
1976-01-01
Describes the Simple Averaging Model (SAM) which was developed to demonstrate impression-formation computer modeling with less complex and less expensive procedures than are required by most established programs. (RC)
Average monthly and annual climate maps for Bolivia
Vicente-Serrano, Sergio M.
2015-02-24
This study presents monthly and annual climate maps for relevant hydroclimatic variables in Bolivia. We used the most complete network of precipitation and temperature stations available in Bolivia, which passed a careful quality control and temporal homogenization procedure. Monthly average maps at the spatial resolution of 1 km were modeled by means of a regression-based approach using topographic and geographic variables as predictors. The monthly average maximum and minimum temperatures, precipitation and potential exoatmospheric solar radiation under clear sky conditions are used to estimate the monthly average atmospheric evaporative demand by means of the Hargreaves model. Finally, the average water balance is estimated on a monthly and annual scale for each 1 km cell by means of the difference between precipitation and atmospheric evaporative demand. The digital layers used to create the maps are available in the digital repository of the Spanish National Research Council.
United States Average Annual Precipitation, 1961-1990 - Direct Download
U.S. Geological Survey, Department of the Interior — This map layer shows polygons of average annual precipitation in the contiguous United States, for the climatological period 1961-1990. Parameter-elevation...
The average-shadowing property and topological ergodicity for flows
Energy Technology Data Exchange (ETDEWEB)
Gu Rongbao [School of Finance, Nanjing University of Finance and Economics, Nanjing 210046 (China)]. E-mail: rbgu@njue.edu.cn; Guo Wenjing [School of Finance, Nanjing University of Finance and Economics, Nanjing 210046 (China)
2005-07-01
In this paper, the transitive property for a flow without sensitive dependence on initial conditions is studied and it is shown that a Lyapunov stable flow with the average-shadowing property on a compact metric space is topologically ergodic.
Time averaging, ageing and delay analysis of financial time series
Cherstvy, Andrey G.; Vinod, Deepak; Aghion, Erez; Chechkin, Aleksei V.; Metzler, Ralf
2017-06-01
We introduce three strategies for the analysis of financial time series based on time averaged observables. These comprise the time averaged mean squared displacement (MSD) as well as the ageing and delay time methods for varying fractions of the financial time series. We explore these concepts via statistical analysis of historic time series for several Dow Jones Industrial indices for the period from the 1960s to 2015. Remarkably, we discover a simple universal law for the delay time averaged MSD. The observed features of the financial time series dynamics agree well with our analytical results for the time averaged measurables for geometric Brownian motion, underlying the famed Black-Scholes-Merton model. The concepts we promote here are shown to be useful for financial data analysis and enable one to unveil new universal features of stock market dynamics.
Ensemble vs. time averages in financial time series analysis
Seemann, Lars; Hua, Jia-Chen; McCauley, Joseph L.; Gunaratne, Gemunu H.
2012-12-01
Empirical analysis of financial time series suggests that the underlying stochastic dynamics are not only non-stationary, but also exhibit non-stationary increments. However, financial time series are commonly analyzed using the sliding interval technique that assumes stationary increments. We propose an alternative approach that is based on an ensemble over trading days. To determine the effects of time averaging techniques on analysis outcomes, we create an intraday activity model that exhibits periodic variable diffusion dynamics and we assess the model data using both ensemble and time averaging techniques. We find that ensemble averaging techniques detect the underlying dynamics correctly, whereas sliding intervals approaches fail. As many traded assets exhibit characteristic intraday volatility patterns, our work implies that ensemble averages approaches will yield new insight into the study of financial markets’ dynamics.
On the average exponent of elliptic curves modulo $p$
Freiberg, Tristan
2012-01-01
Given an elliptic curve $E$ defined over $\\mathbb{Q}$ and a prime $p$ of good reduction, let $\\tilde{E}(\\mathbb{F}_p)$ denote the group of $\\mathbb{F}_p$-points of the reduction of $E$ modulo $p$, and let $e_p$ denote the exponent of said group. Assuming a certain form of the Generalized Riemann Hypothesis (GRH), we study the average of $e_p$ as $p \\le X$ ranges over primes of good reduction, and find that the average exponent essentially equals $p\\cdot c_{E}$, where the constant $c_{E} > 0$ depends on $E$. For $E$ without complex multiplication (CM), $c_{E}$ can be written as a rational number (depending on $E$) times a universal constant. Without assuming GRH, we can determine the average exponent when $E$ has CM, as well as give an upper bound on the average in the non-CM case.
Model Averaging Software for Dichotomous Dose Response Risk Estimation
Directory of Open Access Journals (Sweden)
Matthew W. Wheeler
2008-02-01
Full Text Available Model averaging has been shown to be a useful method for incorporating model uncertainty in quantitative risk estimation. In certain circumstances this technique is computationally complex, requiring sophisticated software to carry out the computation. We introduce software that implements model averaging for risk assessment based upon dichotomous dose-response data. This software, which we call Model Averaging for Dichotomous Response Benchmark Dose (MADr-BMD, ﬁts the quantal response models, which are also used in the US Environmental Protection Agency benchmark dose software suite, and generates a model-averaged dose response model to generate benchmark dose and benchmark dose lower bound estimates. The software fulﬁlls a need for risk assessors, allowing them to go beyond one single model in their risk assessments based on quantal data by focusing on a set of models that describes the experimental data.
United States Average Annual Precipitation, 1995-1999 - Direct Download
U.S. Geological Survey, Department of the Interior — This map layer shows polygons of average annual precipitation in the contiguous United States, for the climatological period 1995-1999. Parameter-elevation...
United States Average Annual Precipitation, 1990-1994 - Direct Download
U.S. Geological Survey, Department of the Interior — This map layer shows polygons of average annual precipitation in the contiguous United States, for the climatological period 1990-1994. Parameter-elevation...
United States Average Annual Precipitation, 1990-2009 - Direct Download
U.S. Geological Survey, Department of the Interior — This map layer shows polygons of average annual precipitation in the contiguous United States, for the climatological period 1990-2009. Parameter-elevation...
Does subduction zone magmatism produce average continental crust
Ellam, R. M.; Hawkesworth, C. J.
1988-01-01
The question of whether present day subduction zone magmatism produces material of average continental crust composition, which perhaps most would agree is andesitic, is addressed. It was argued that modern andesitic to dacitic rocks in Andean-type settings are produced by plagioclase fractionation of mantle derived basalts, leaving a complementary residue with low Rb/Sr and a positive Eu anomaly. This residue must be removed, for example by delamination, if the average crust produced in these settings is andesitic. The author argued against this, pointing out the absence of evidence for such a signature in the mantle. Either the average crust is not andesitic, a conclusion the author was not entirely comfortable with, or other crust forming processes must be sought. One possibility is that during the Archean, direct slab melting of basaltic or eclogitic oceanic crust produced felsic melts, which together with about 65 percent mafic material, yielded an average crust of andesitic composition.
Historical Data for Average Processing Time Until Hearing Held
Social Security Administration — This dataset provides historical data for average wait time (in days) from the hearing request date until a hearing was held. This dataset includes data from fiscal...
Bivariate copulas on the exponentially weighted moving average control chart
Directory of Open Access Journals (Sweden)
Sasigarn Kuvattana
2016-10-01
Full Text Available This paper proposes four types of copulas on the Exponentially Weighted Moving Average (EWMA control chart when observations are from an exponential distribution using a Monte Carlo simulation approach. The performance of the control chart is based on the Average Run Length (ARL which is compared for each copula. Copula functions for specifying dependence between random variables are used and measured by Kendall’s tau. The results show that the Normal copula can be used for almost all shifts.
Time averages, recurrence and transience in the stochastic replicator dynamics
Hofbauer, Josef; 10.1214/08-AAP577
2009-01-01
We investigate the long-run behavior of a stochastic replicator process, which describes game dynamics for a symmetric two-player game under aggregate shocks. We establish an averaging principle that relates time averages of the process and Nash equilibria of a suitably modified game. Furthermore, a sufficient condition for transience is given in terms of mixed equilibria and definiteness of the payoff matrix. We also present necessary and sufficient conditions for stochastic stability of pure equilibria.
On the relativistic mass function and averaging in cosmology
Ostrowski, Jan J; Roukema, Boudewijn F
2016-01-01
The general relativistic description of cosmological structure formation is an important challenge from both the theoretical and the numerical point of views. In this paper we present a brief prescription for a general relativistic treatment of structure formation and a resulting mass function on galaxy cluster scales in a highly generic scenario. To obtain this we use an exact scalar averaging scheme together with the relativistic generalization of Zel'dovich's approximation (RZA) that serves as a closure condition for the averaged equations.
Use of a Correlation Coefficient for Conditional Averaging.
1997-04-01
data. Selection of the sine function period and a correlation coefficient threshold are discussed. Also examined are the effects of the period and...threshold level on the number of ensembles captured for inclusion for conditional averaging. Both the selection of threshold correlation coefficient and the...A method of collecting ensembles for conditional averaging is presented that uses data collected from a plane mixing layer. The correlation
Estimation of annual average daily traffic with optimal adjustment factors
Alonso Oreña, Borja; Moura Berodia, José Luis; Ibeas Portilla, Ángel; Romero Junquera, Juan Pablo
2014-01-01
This study aimed to estimate the annual average daily traffic in inter-urban networks determining the best correlation (affinity) between the short period traffic counts and permanent traffic counters. A bi-level optimisation problem is proposed in which an agent in an upper level prefixes the affinities between short period traffic counts and permanent traffic counters stations and looks to minimise the annual average daily traffic calculation error while, in a lower level, an origin–destina...
The averaging of nonlocal Hamiltonian structures in Whitham's method
Directory of Open Access Journals (Sweden)
Andrei Ya. Maltsev
2002-01-01
Full Text Available We consider the m-phase Whitham's averaging method and propose the procedure of averaging nonlocal Hamiltonian structures. The procedure is based on the existence of a sufficient number of local-commuting integrals of the system and gives the Poisson bracket of Ferapontov type for Whitham's system. The method can be considered as the generalization of the Dubrovin-Novikov procedure for the local field-theoretical brackets.
Separability criteria with angular and Hilbert space averages
Fujikawa, Kazuo; Oh, C. H.; Umetsu, Koichiro; Yu, Sixia
2016-05-01
The practically useful criteria of separable states ρ =∑kwkρk in d = 2 × 2 are discussed. The equality G(a , b) = 4 [ - ] = 0 for any two projection operators P(a) and P(b) provides a necessary and sufficient separability criterion in the case of a separable pure state ρ = | ψ > Werner state is applied to two photon systems, it is shown that the Hilbert space average can judge its inseparability but not the geometrical angular average.
A precise measurement of the average b hadron lifetime
Buskulic, Damir; De Bonis, I; Décamp, D; Ghez, P; Goy, C; Lees, J P; Lucotte, A; Minard, M N; Odier, P; Pietrzyk, B; Ariztizabal, F; Chmeissani, M; Crespo, J M; Efthymiopoulos, I; Fernández, E; Fernández-Bosman, M; Gaitan, V; Garrido, L; Martínez, M; Orteu, S; Pacheco, A; Padilla, C; Palla, Fabrizio; Pascual, A; Perlas, J A; Sánchez, F; Teubert, F; Colaleo, A; Creanza, D; De Palma, M; Farilla, A; Gelao, G; Girone, M; Iaselli, Giuseppe; Maggi, G; Maggi, M; Marinelli, N; Natali, S; Nuzzo, S; Ranieri, A; Raso, G; Romano, F; Ruggieri, F; Selvaggi, G; Silvestris, L; Tempesta, P; Zito, G; Huang, X; Lin, J; Ouyang, Q; Wang, T; Xie, Y; Xu, R; Xue, S; Zhang, J; Zhang, L; Zhao, W; Bonvicini, G; Cattaneo, M; Comas, P; Coyle, P; Drevermann, H; Engelhardt, A; Forty, Roger W; Frank, M; Hagelberg, R; Harvey, J; Jacobsen, R; Janot, P; Jost, B; Knobloch, J; Lehraus, Ivan; Markou, C; Martin, E B; Mato, P; Meinhard, H; Minten, Adolf G; Miquel, R; Oest, T; Palazzi, P; Pater, J R; Pusztaszeri, J F; Ranjard, F; Rensing, P E; Rolandi, Luigi; Schlatter, W D; Schmelling, M; Schneider, O; Tejessy, W; Tomalin, I R; Venturi, A; Wachsmuth, H W; Wiedenmann, W; Wildish, T; Witzeling, W; Wotschack, J; Ajaltouni, Ziad J; Bardadin-Otwinowska, Maria; Barrès, A; Boyer, C; Falvard, A; Gay, P; Guicheney, C; Henrard, P; Jousset, J; Michel, B; Monteil, S; Montret, J C; Pallin, D; Perret, P; Podlyski, F; Proriol, J; Rossignol, J M; Saadi, F; Fearnley, Tom; Hansen, J B; Hansen, J D; Hansen, J R; Hansen, P H; Nilsson, B S; Kyriakis, A; Simopoulou, Errietta; Siotis, I; Vayaki, Anna; Zachariadou, K; Blondel, A; Bonneaud, G R; Brient, J C; Bourdon, P; Passalacqua, L; Rougé, A; Rumpf, M; Tanaka, R; Valassi, Andrea; Verderi, M; Videau, H L; Candlin, D J; Parsons, M I; Focardi, E; Parrini, G; Corden, M; Delfino, M C; Georgiopoulos, C H; Jaffe, D E; Antonelli, A; Bencivenni, G; Bologna, G; Bossi, F; Campana, P; Capon, G; Chiarella, V; Felici, G; Laurelli, P; Mannocchi, G; Murtas, F; Murtas, G P; Pepé-Altarelli, M; Dorris, S J; Halley, A W; ten Have, I; Knowles, I G; Lynch, J G; Morton, W T; O'Shea, V; Raine, C; Reeves, P; Scarr, J M; Smith, K; Smith, M G; Thompson, A S; Thomson, F; Thorn, S; Turnbull, R M; Becker, U; Braun, O; Geweniger, C; Graefe, G; Hanke, P; Hepp, V; Kluge, E E; Putzer, A; Rensch, B; Schmidt, M; Sommer, J; Stenzel, H; Tittel, K; Werner, S; Wunsch, M; Beuselinck, R; Binnie, David M; Cameron, W; Colling, D J; Dornan, Peter J; Konstantinidis, N P; Moneta, L; Moutoussi, A; Nash, J; San Martin, G; Sedgbeer, J K; Stacey, A M; Dissertori, G; Girtler, P; Kneringer, E; Kuhn, D; Rudolph, G; Bowdery, C K; Brodbeck, T J; Colrain, P; Crawford, G; Finch, A J; Foster, F; Hughes, G; Sloan, Terence; Whelan, E P; Williams, M I; Galla, A; Greene, A M; Kleinknecht, K; Quast, G; Raab, J; Renk, B; Sander, H G; Wanke, R; Van Gemmeren, P; Zeitnitz, C; Aubert, Jean-Jacques; Bencheikh, A M; Benchouk, C; Bonissent, A; Bujosa, G; Calvet, D; Carr, J; Diaconu, C A; Etienne, F; Thulasidas, M; Nicod, D; Payre, P; Rousseau, D; Talby, M; Abt, I; Assmann, R W; Bauer, C; Blum, Walter; Brown, D; Dietl, H; Dydak, Friedrich; Ganis, G; Gotzhein, C; Jakobs, K; Kroha, H; Lütjens, G; Lutz, Gerhard; Männer, W; Moser, H G; Richter, R H; Rosado-Schlosser, A; Schael, S; Settles, Ronald; Seywerd, H C J; Stierlin, U; Saint-Denis, R; Wolf, G; Alemany, R; Boucrot, J; Callot, O; Cordier, A; Courault, F; Davier, M; Duflot, L; Grivaz, J F; Heusse, P; Jacquet, M; Kim, D W; Le Diberder, F R; Lefrançois, J; Lutz, A M; Musolino, G; Nikolic, I A; Park, H J; Park, I C; Schune, M H; Simion, S; Veillet, J J; Videau, I; Abbaneo, D; Azzurri, P; Bagliesi, G; Batignani, G; Bettarini, S; Bozzi, C; Calderini, G; Carpinelli, M; Ciocci, M A; Ciulli, V; Dell'Orso, R; Fantechi, R; Ferrante, I; Foà, L; Forti, F; Giassi, A; Giorgi, M A; Gregorio, A; Ligabue, F; Lusiani, A; Marrocchesi, P S; Messineo, A; Rizzo, G; Sanguinetti, G; Sciabà, A; Spagnolo, P; Steinberger, Jack; Tenchini, Roberto; Tonelli, G; Triggiani, G; Vannini, C; Verdini, P G; Walsh, J; Betteridge, A P; Blair, G A; Bryant, L M; Cerutti, F; Gao, Y; Green, M G; Johnson, D L; Medcalf, T; Mir, L M; Perrodo, P; Strong, J A; Bertin, V; Botterill, David R; Clifft, R W; Edgecock, T R; Haywood, S; Edwards, M; Maley, P; Norton, P R; Thompson, J C; Bloch-Devaux, B; Colas, P; Duarte, H; Emery, S; Kozanecki, Witold; Lançon, E; Lemaire, M C; Locci, E; Marx, B; Pérez, P; Rander, J; Renardy, J F; Rosowsky, A; Roussarie, A; Schuller, J P; Schwindling, J; Si Mohand, D; Trabelsi, A; Vallage, B; Johnson, R P; Kim, H Y; Litke, A M; McNeil, M A; Taylor, G; Beddall, A; Booth, C N; Boswell, R; Cartwright, S L; Combley, F; Dawson, I; Köksal, A; Letho, M; Newton, W M; Rankin, C; Thompson, L F; Böhrer, A; Brandt, S; Cowan, G D; Feigl, E; Grupen, Claus; Lutters, G; Minguet-Rodríguez, J A; Rivera, F; Saraiva, P; Smolik, L; Stephan, F; Apollonio, M; Bosisio, L; Della Marina, R; Giannini, G; Gobbo, B; Ragusa, F; Rothberg, J E; Wasserbaech, S R; Armstrong, S R; Bellantoni, L; Elmer, P; Feng, P; Ferguson, D P S; Gao, Y S; González, S; Grahl, J; Harton, J L; Hayes, O J; Hu, H; McNamara, P A; Nachtman, J M; Orejudos, W; Pan, Y B; Saadi, Y; Schmitt, M; Scott, I J; Sharma, V; Turk, J; Walsh, A M; Wu Sau Lan; Wu, X; Yamartino, J M; Zheng, M; Zobernig, G
1996-01-01
An improved measurement of the average b hadron lifetime is performed using a sample of 1.5 million hadronic Z decays, collected during the 1991-1993 runs of ALEPH, with the silicon vertex detector fully operational. This uses the three-dimensional impact parameter distribution of lepton tracks coming from semileptonic b decays and yields an average b hadron lifetime of 1.533 \\pm 0.013 \\pm 0.022 ps.
Average life of oxygen vacancies of quartz in sediments
Institute of Scientific and Technical Information of China (English)
DIAO; Shaobo(刁少波); YE; Yuguang(业渝光)
2002-01-01
Average life of oxygen vacancies of quartz in sediments is estimated by using the ESR (electron spin resonance) signals of E( centers from the thermal activation technique. The experimental results show that the second-order kinetics equation is more applicable to the life estimation compared with the first order equation. The average life of oxygen vacancies of quartz from 4895 to 4908 deep sediments in the Tarim Basin is about 1018 a at 27℃.
Rising cost of anticancer drugs in Australia.
Karikios, D J; Schofield, D; Salkeld, G; Mann, K P; Trotman, J; Stockler, M R
2014-05-01
Anticancer drugs are often expensive and are contributing to the growing cost of cancer care. Concerns have been raised about the effect rising costs may have on availability of new anticancer drugs. This study aims to determine the recent changes in the costs of anticancer drugs in Australia. Publicly available expenditure and prices paid by the Australian Pharmaceutical Benefits Scheme (PBS) for anticancer drugs from 2000 to 2012 were reviewed. The measures used to determine changes in cost were total PBS expenditure and average price paid by the PBS per prescription for anticancer drugs and for all PBS listed drugs. An estimated monthly price paid for newly listed anticancer drugs was also calculated. Annual PBS expenditure on anticancer drugs rose from A$65 million in 1999-2000 to A$466 million in 2011-2012; an average increase of 19% per annum. The average price paid by the PBS per anticancer drug prescription, adjusted for inflation, increased 133% from A$337 to A$786. The real average annual increase in the price per anticancer drug prescription was more than double that for all other PBS drugs combined (7.6% vs 2.8%, difference 4.8%, 95% confidence interval -0.4% to 10.1%, P = 0.07). The median price for a month's treatment of the new anticancer drugs listed was A$4919 (range A$1003 to A$12 578, 2012 prices). PBS expenditure and the price of anticancer drugs in Australia rose substantially from 2000 to 2012. Dealing with these burgeoning costs will be a major challenge for our health system and for those affected by cancer. © 2014 The Authors; Internal Medicine Journal © 2014 Royal Australasian College of Physicians.
The Drug Sensitivity of Cyclosporine A Combined with Antineoplastic Drugs in Retinoblastoma in Vitro
Institute of Scientific and Technical Information of China (English)
Wanli Liu; Zhongyao Wu
2005-01-01
Purpose: To study cyclosporine A inhibition on the fresh retinoblastoma cells in vitro and increasing the drug sensitivity after combined with different antineoplastic drugs.Methods: To study the growth curve of cyclosporine A on 27 samples of primary retinoblastoma cells by MTT assay and to study the change of the drug sensitivity by cyclosporine A combined with seven antineoplastic drugs.Results: The average IC50 of cyclosporine A on the 27 retinoblastoma cells is 67.81μg/ml and the average inhibitive rate of these samples is 26.1% when cyclosporine A is in the concentration of 2μg/ml. The inhibitive rates all got improved after the seven antineoplastic drugs combined with cyclosporine A and the increasing average inhibitive rate is more than 5.Conclusion: Cyclosporine A can inhibit retinoblastoma cells in vitro and its inhibitive effect is dose dependent. Moreover it can enhance the inhibition of multiple antineoplastic drugs on retinoblastoma cells.
Cycle Average Peak Fuel Temperature Prediction Using CAPP/GAMMA+
Energy Technology Data Exchange (ETDEWEB)
Tak, Nam-il; Lee, Hyun Chul; Lim, Hong Sik [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)
2015-10-15
In order to obtain a cycle average maximum fuel temperature without rigorous efforts, a neutronics/thermo-fluid coupled calculation is needed with depletion capability. Recently, a CAPP/GAMMA+ coupled code system has been developed and the initial core of PMR200 was analyzed using the CAPP/GAMMA+ code system. The GAMMA+ code is a system thermo-fluid analysis code and the CAPP code is a neutronics code. The General Atomics proposed that the design limit of the fuel temperature under normal operating conditions should be a cycle-averaged maximum value. Nonetheless, the existing works of Korea Atomic Energy Research Institute (KAERI) only calculated the maximum fuel temperature at a fixed time point, e.g., the beginning of cycle (BOC) just because the calculation capability was not ready for a cycle average value. In this work, a cycle average maximum fuel temperature has been calculated using CAPP/GAMMA+ code system for the equilibrium core of PMR200. The CAPP/GAMMA+ coupled calculation was carried out for the equilibrium core of PMR 200 from BOC to EOC to obtain a cycle average peak fuel temperature. The peak fuel temperature was predicted to be 1372 .deg. C near MOC. However, the cycle average peak fuel temperature was calculated as 1181 .deg. C, which is below the design target of 1250 .deg. C.
Chronic obstructive pulmonary disease - control drugs; Bronchodilators - COPD - control drugs; Beta agonist inhaler - COPD - control drugs; Anticholinergic inhaler - COPD - control drugs; Long-acting inhaler - COPD - ...
Bruno, Antonio; Scimeca, Giuseppe; Marino, Antonio G; Mento, Carmela; Micò, Umberto; Romeo, Vincenzo M; Pandolfo, Gianluca; Zoccali, Rocco; Muscatello, Maria R A
2012-01-01
This study investigated the association between drugs and sexual behavior in a sample of polydrug substance abusers recruited from several Italian therapeutic communities; participants were 90 polydrug substance abusers (opiates, cocaine, amphetamine, inhalants, marijuana/sedatives or hallucinogens abusers) who were compared with 90 nonsubstance-abusing individuals. Sexual behavior was measured by the Italian version of the Sex and the Average Woman (or Man; SAWM), a questionnaire that assesses different kind of sexual attitudes. Results showed that drug-abusing individuals are particularly inclined to search for sexual intercourse and are open to different kinds of sexual experiences; however, they have difficulties in establishing committed and deep relationships with their partners, showing signs of inhibition, affective detachment or anger. Their sexual lives are also surrounded by negative emotions, disturbing thoughts and maladjusted behaviors. The importance of integrating sexual problems into therapeutic strategies is discussed.
Herbal drugs and drug interactions
Directory of Open Access Journals (Sweden)
Gül Dülger
2012-01-01
Full Text Available Herbal drugs are defined as any form of a plant or plant product that contains a single herb or combinations of herbs that are believed to have complementary effects. Although they are considered to be safe, because they are natural, they may have various adverse effects, and may interact with other herbal products or conventional drugs. These interactions are especially important for drugs with narrow therapeutic indices.In the present study, pharmacokinetic and pharmacodynamic interactions of some most commanly used herbals (St John's wort, ginkgo biloba, ginseng, ginger, garlic, echinacea, ephedra and valerian with the conventional drugs were reviewed. Pharmacokinetic interactions involve mainly induction or inhibition of the cytochrome P450 isozymes and p-glycoproteins by the herbal medicine, thus changing the absorption and/or elimination rate and consequently the efficacy of the concommitantly used drugs. St John's wort, a well known enzyme inducer, decreases the efficacy of most of the other drugs that are known to be the substrates of these enzymes.Pharmacodynamic interactions may be due to additive or synergistic effects which results in enhanced effect or toxicity, or herbal medicines with antagonistic properties reduce drug efficacy and result in therapeutic failure. For exampla, St John's wort may have synergistic effects with other antidepressant drugs used by the patient, resulting in increased CNS effects.Herbals like ginseng, ginkgo, garlic, ginger were reported to increase bleeding time, thus potentiating the effect of anticoagulant and antithrombotic agents. In conclusion, patients should be warned against the interaction between the herbal products and conventional medicines.
Exact Averaging of Stochastic Equations for Flow in Porous Media
Energy Technology Data Exchange (ETDEWEB)
Karasaki, Kenzi; Shvidler, Mark; Karasaki, Kenzi
2008-03-15
It is well known that at present, exact averaging of the equations for flow and transport in random porous media have been proposed for limited special fields. Moreover, approximate averaging methods--for example, the convergence behavior and the accuracy of truncated perturbation series--are not well studied, and in addition, calculation of high-order perturbations is very complicated. These problems have for a long time stimulated attempts to find the answer to the question: Are there in existence some, exact, and sufficiently general forms of averaged equations? Here, we present an approach for finding the general exactly averaged system of basic equations for steady flow with sources in unbounded stochastically homogeneous fields. We do this by using (1) the existence and some general properties of Green's functions for the appropriate stochastic problem, and (2) some information about the random field of conductivity. This approach enables us to find the form of the averaged equations without directly solving the stochastic equations or using the usual assumption regarding any small parameters. In the common case of a stochastically homogeneous conductivity field we present the exactly averaged new basic nonlocal equation with a unique kernel-vector. We show that in the case of some type of global symmetry (isotropy, transversal isotropy, or orthotropy), we can for three-dimensional and two-dimensional flow in the same way derive the exact averaged nonlocal equations with a unique kernel-tensor. When global symmetry does not exist, the nonlocal equation with a kernel-tensor involves complications and leads to an ill-posed problem.
Simple Moving Average: A Method of Reporting Evolving Complication Rates.
Harmsen, Samuel M; Chang, Yu-Hui H; Hattrup, Steven J
2016-09-01
Surgeons often cite published complication rates when discussing surgery with patients. However, these rates may not truly represent current results or an individual surgeon's experience with a given procedure. This study proposes a novel method to more accurately report current complication trends that may better represent the patient's potential experience: simple moving average. Reverse shoulder arthroplasty (RSA) is an increasingly popular and rapidly evolving procedure with highly variable reported complication rates. The authors used an RSA model to test and evaluate the usefulness of simple moving average. This study reviewed 297 consecutive RSA procedures performed by a single surgeon and noted complications in 50 patients (16.8%). Simple moving average for total complications as well as minor, major, acute, and chronic complications was then calculated using various lag intervals. These findings showed trends toward fewer total, major, and chronic complications over time, and these trends were represented best with a lag of 75 patients. Average follow-up within this lag was 26.2 months. Rates for total complications decreased from 17.3% to 8% at the most recent simple moving average. The authors' traditional complication rate with RSA (16.8%) is consistent with reported rates. However, the use of simple moving average shows that this complication rate decreased over time, with current trends (8%) markedly lower, giving the senior author a more accurate picture of his evolving complication trends with RSA. Compared with traditional methods, simple moving average can be used to better reflect current trends in complication rates associated with a surgical procedure and may better represent the patient's potential experience. [Orthopedics.2016; 39(5):e869-e876.].
Kazemi, Mark; Silva, Matthew D; Li, Fuhai; Fisher, Marc; Sotak, Christopher H
2004-06-01
Stroke lesion-volume estimates derived from calculated water apparent diffusion coefficient (ADC) maps provide a quantitative surrogate end-point for investigating the efficacy of drug treatment or studying the temporal evolution of cerebral ischemia. Methodology is described for estimating ischemic lesion volumes in a rat model of permanent middle cerebral artery occlusion (MCAO) based on absolute and percent-reduction threshold values of the water ADC at 3 h post-MCAO. Volume estimates derived from average ADC (ADC(av)) maps were compared with those derived from post-mortem histological sections. Optimum ADC thresholds were established as those that provided the best correlation and one-to-one correspondence between ADC- and histologically derived lesion-volume estimates. At 3 h post-MCAO, an absolute-ADC(av) threshold of 47 x 10(-5) mm(2)/s (corresponding to a 33% reduction in ADC(av) based on a contralateral hemisphere comparison) provided the most accurate estimate of percent hemispheric lesion volume (%HLV). Experimental and data analysis issues for improving and validating the usefulness of DWI as a surrogate endpoint for the quantification of ischemic lesion volume are discussed.
Drugs and Death. National Institute on Drug Abuse Research Issues 6.
Ferguson, Patricia, Ed.; And Others
This report is the sixth in a series of reports designed to summarize the empirical research findings and major theoretical approaches relating to the issues of drug use and abuse. This volume reviews some of the major research studies which explore the nonmedical use of drugs as it relates to all modes of death. Included are studies describing…
Distribution of population averaged observables in stochastic gene expression
Bhattacharyya, Bhaswati; Kalay, Ziya
2014-03-01
Observation of phenotypic diversity in a population of genetically identical cells is often linked to the stochastic nature of chemical reactions involved in gene regulatory networks. We investigate the distribution of population averaged gene expression levels as a function of population, or sample size for several stochastic gene expression models to find out to what extent population averaged quantities reflect the underlying mechanism of gene expression. We consider three basic gene regulation networks corresponding to transcription with and without gene state switching and translation. Using analytical expressions for the probability generating function (pgf) of observables and Large Deviation Theory, we calculate the distribution of population averaged mRNA and protein levels as a function of model parameters and population size. We validate our results using stochastic simulations also report exact results on the asymptotic properties of population averages which show qualitative differences for different models. We calculate the skewness and coefficient of variance for pgfs to estimate the sample size required for population average that contains information about gene expression models. This is relevant to experiments where a large number of data points are unavailable.
Averaged universe confronted to cosmological observations: a fully covariant approach
Wijenayake, Tharake; Ishak, Mustapha
2016-01-01
One of the outstanding problems in general relativistic cosmology is that of the averaging. That is, how the lumpy universe that we observe at small scales averages out to a smooth Friedmann-Lemaitre-Robertson-Walker (FLRW) model. The root of the problem is that averaging does not commute with the Einstein equations that govern the dynamics of the model. This leads to the well-know question of backreaction in cosmology. In this work, we approach the problem using the covariant framework of Macroscopic Gravity (MG). We use its cosmological solution with a flat FLRW macroscopic background where the result of averaging cosmic inhomogeneities has been encapsulated into a backreaction density parameter denoted $\\Omega_\\mathcal{A}$. We constrain this averaged universe using available cosmological data sets of expansion and growth including, for the first time, a full CMB analysis from Planck temperature anisotropy and polarization data, the supernovae data from Union 2.1, the galaxy power spectrum from WiggleZ, the...
Perceptual averaging in individuals with Autism Spectrum Disorder
Directory of Open Access Journals (Sweden)
Jennifer Elise Corbett
2016-11-01
Full Text Available There is mounting evidence that observers rely on statistical summaries of visual information to maintain stable and coherent perception. Sensitivity to the mean (or other prototypical value of a visual feature (e.g., mean size appears to be a pervasive process in human visual perception. Previous studies in individuals diagnosed with Autism Spectrum Disorder (ASD have uncovered characteristic patterns of visual processing that suggest they may rely more on enhanced local representations of individual objects instead of computing such perceptual averages. To further explore the fundamental nature of abstract statistical representation in visual perception, we investigated perceptual averaging of mean size in a group of 12 high-functioning individuals diagnosed with ASD using simplified versions of two identification and adaptation tasks that elicited characteristic perceptual averaging effects in a control group of neurotypical participants. In Experiment 1, participants performed with above chance accuracy in recalling the mean size of a set of circles (mean task despite poor accuracy in recalling individual circle sizes (member task. In Experiment 2, their judgments of single circle size were biased by mean size adaptation. Overall, these results suggest that individuals with ASD perceptually average information about sets of objects in the surrounding environment. Our results underscore the fundamental nature of perceptual averaging in vision, and further our understanding of how autistic individuals make sense of the external environment.
Transversely isotropic higher-order averaged structure tensors
Hashlamoun, Kotaybah; Federico, Salvatore
2017-08-01
For composites or biological tissues reinforced by statistically oriented fibres, a probability distribution function is often used to describe the orientation of the fibres. The overall effect of the fibres on the material response is accounted for by evaluating averaging integrals over all possible directions in space. The directional average of the structure tensor (tensor product of the unit vector describing the fibre direction by itself) is of high significance. Higher-order averaged structure tensors feature in several models and carry similarly important information. However, their evaluation has a quite high computational cost. This work proposes to introduce mathematical techniques to minimise the computational cost associated with the evaluation of higher-order averaged structure tensors, for the case of a transversely isotropic probability distribution of orientation. A component expression is first introduced, using which a general tensor expression is obtained, in terms of an orthonormal basis in which one of the vectors coincides with the axis of symmetry of transverse isotropy. Then, a higher-order transversely isotropic averaged structure tensor is written in an appropriate basis, constructed starting from the basis of the space of second-order transversely isotropic tensors, which is constituted by the structure tensor and its complement to the identity.
Preparation and Drug-release Behavior of β-TCP Ceramics Drug Carrier in vitro
Institute of Scientific and Technical Information of China (English)
ZHANG Qihuan; YAN Xin; YAN Yuhua; DAI Honglian; JIANG Xin; LI Shipu
2012-01-01
β-TCP ceramics drug carrier was first prepared and characterized.SEM showed that β-TCP carrier was in porous amorphous structure with diameters around 10 μm.The physical properties including apparent porosity,volume-weight,tensile strength and the permeability were measured and the results indicated those properties fit the clinical usage of β-TCP drug carrier.Furthermore,drug release experiment in vitro showed that the carrier could prolong drug release in simulated body fluid which provides basis for the clinical use of β-TCP ceramics as drug carrier.
Price Sensitivity of Demand for Prescription Drugs
DEFF Research Database (Denmark)
Skipper, Lars; Simonsen, Marianne; Skipper, Niels
This paper investigates price sensitivity of demand for prescription drugs using drug purchase records for at 20% random sample of the Danish population. We identify price responsiveness by exploiting exogenous variation in prices caused by kinked reimbursement schemes and implement a regression ...... education and income are, however, more responsive to the price. Also, essential drugs that prevent deterioration in health and prolong life have lower associated average price sensitivity....
Lifescience Database Archive (English)
Full Text Available D07729 Drug Clopidogrel (INN); Clopidogrel (TN); Plavix (TN) C16H16ClNO2S 321.059 3...status is associated with diminished response to Clopidogrel. P2Y12 receptor antagonist [HSA:64805] [KO:K042...rs excl. heparin B01AC04 Clopidogrel D07729 Clopidogrel (INN) USP drug classification [BR:br08302] Blood Pro...ducts/Modifiers/Volume Expanders Platelet Modifying Agents Clopidogrel D07729 Clopidogrel (INN) Target-based...y Purine / pyrimidine P2Y12 receptor [HSA:64805] [KO:K04298] Clopidogrel [ATC:B01AC04] D07729 Clopidogrel (I
Lifescience Database Archive (English)
Full Text Available D03335 Drug Hydroxyethylated starch (JAN); Hetastarch (USAN); Hydroxyethylstarch; H...espan (TN) Plasma volume extender Therapeutic category: 3319 ATC code: B05AA07 Therapeutic category of drugs... in Japan [BR:br08301] 3 Agents affecting metabolism 33 Blood and body fluid agents 331 Blood substitutes 3319 Others D03335 Hydr...D PERFUSION SOLUTIONS B05A BLOOD AND RELATED PRODUCTS B05AA Blood substitutes and plasma protein fractions B05AA07 Hydr...oxyethylstarch D03335 Hydroxyethylated starch (JAN); Hetastarch (USAN) CAS: 9005-27-0 PubChem: 17397485 ...
DEFF Research Database (Denmark)
Klausen, Thomas Kjær
- serves a multitude of functions in the mammalian cell, regulating the membrane potential (Em), cell volume, protein activity and the driving force for facilitated transporters giving Cl- and Cl- channels a major potential of regulating cellular function. These functions include control of the cell cycle...... of volume perturbations evolution have developed system of channels and transporters to tightly control volume homeostasis. In the past decades evidence has been mounting, that the importance of these volume regulated channels and transporters are not restricted to the defense of cellular volume......, controlled cell death and cellular migration. Volume regulatory mechanisms has long been in focus for regulating cellular proliferation and my thesis work have been focusing on the role of Cl- channels in proliferation with specific emphasis on ICl, swell. Pharmacological blockage of the ubiquitously...
How do children form impressions of persons? They average.
Hendrick, C; Franz, C M; Hoving, K L
1975-05-01
The experiment reported was concerned with impression formation in children. Twelve subjects in each of Grades K, 2, 4, and 6 rated several sets of single trait words and trait pairs. The response scale consisted of a graded series of seven schematic faces which ranged from a deep frown to a happy smile. A basic question was whether children use an orderly integration rule in forming impressions of trait pairs. The answer was clear. At all grade levels a simple averaging model adequately accounted for pair ratings. A second question concerned how children resolve semantic inconsistencies. Responses to two highly inconsistent trait pairs suggested that subjects responded in the same fashion, essentially averaging the two traits in a pair. Overall, the data strongly supported an averaging model, and indicated that impression formation of children is similar to previous results obtained from adults.
Optimum orientation versus orientation averaging description of cluster radioactivity
Seif, W M; Refaie, A I; Amer, L H
2016-01-01
Background: The deformation of the nuclei involved in the cluster decay of heavy nuclei affect seriously their half-lives against the decay. Purpose: We investigate the description of the different decay stages in both the optimum orientation and the orientation-averaged pictures of the cluster decay process. Method: We consider the decays of 232,233,234U and 236,238Pu isotopes. The quantum mechanical knocking frequency and penetration probability based on the Wentzel-Kramers-Brillouin approximation are used to find the decay width. Results: We found that the orientation-averaged decay width is one or two orders of magnitude less than its value along the non-compact optimum orientation. The difference between the two values increases with decreasing the mass number of the emitted cluster. Correspondingly, the extracted preformation probability based on the averaged decay width increases with the same orders of magnitude compared to its value obtained considering the optimum orientation. The cluster preformati...
Testing averaged cosmology with type Ia supernovae and BAO data
Santos, B; Devi, N Chandrachani; Alcaniz, J S
2016-01-01
An important problem in precision cosmology is the determination of the effects of averaging and backreaction on observational predictions, particularly in view of the wealth of new observational data and improved statistical techniques. In this paper we discuss the observational viability of a class of averaged cosmologies which consist of a simple parametrized phenomenological two-scale backreaction model with decoupled spatial curvature parameters. We perform a Bayesian model selection analysis and find that this class of averaged phenomenological cosmological models is favored with respect to the standard $\\Lambda$CDM cosmological scenario when a joint analysis of current SNe Ia and BAO data is performed. In particular, the analysis provides observational evidence for non-trivial spatial curvature.
An ɴ-ary λ-averaging based similarity classifier
Directory of Open Access Journals (Sweden)
Kurama Onesfole
2016-06-01
Full Text Available We introduce a new n-ary λ similarity classifier that is based on a new n-ary λ-averaging operator in the aggregation of similarities. This work is a natural extension of earlier research on similarity based classification in which aggregation is commonly performed by using the OWA-operator. So far λ-averaging has been used only in binary aggregation. Here the λ-averaging operator is extended to the n-ary aggregation case by using t-norms and t-conorms. We examine four different n-ary norms and test the new similarity classifier with five medical data sets. The new method seems to perform well when compared with the similarity classifier.
Genuine non-self-averaging and ultraslow convergence in gelation
Cho, Y. S.; Mazza, M. G.; Kahng, B.; Nagler, J.
2016-08-01
In irreversible aggregation processes droplets or polymers of microscopic size successively coalesce until a large cluster of macroscopic scale forms. This gelation transition is widely believed to be self-averaging, meaning that the order parameter (the relative size of the largest connected cluster) attains well-defined values upon ensemble averaging with no sample-to-sample fluctuations in the thermodynamic limit. Here, we report on anomalous gelation transition types. Depending on the growth rate of the largest clusters, the gelation transition can show very diverse patterns as a function of the control parameter, which includes multiple stochastic discontinuous transitions, genuine non-self-averaging and ultraslow convergence of the transition point. Our framework may be helpful in understanding and controlling gelation.
The Conservation of Area Integrals in Averaging Transformations
Kuznetsov, E. D.
2010-06-01
It is shown for the two-planetary version of the weakly perturbed two-body problem that, in a system defined by a finite part of a Poisson expansion of the averaged Hamiltonian, only one of the three components of the area vector is conserved, corresponding to the longitudes measuring plane. The variability of the other two components is demonstrated in two ways. The first is based on calculating the Poisson bracket of the averaged Hamiltonian and the components of the area vector written in closed form. In the second, an echeloned Poisson series processor (EPSP) is used when calculating the Poisson bracket. The averaged Hamiltonian is taken with accuracy to second order in the small parameter of the problem, and the components of the area vector are expanded in a Poisson series.
Evolution of the average avalanche shape with the universality class.
Laurson, Lasse; Illa, Xavier; Santucci, Stéphane; Tore Tallakstad, Ken; Måløy, Knut Jørgen; Alava, Mikko J
2013-01-01
A multitude of systems ranging from the Barkhausen effect in ferromagnetic materials to plastic deformation and earthquakes respond to slow external driving by exhibiting intermittent, scale-free avalanche dynamics or crackling noise. The avalanches are power-law distributed in size, and have a typical average shape: these are the two most important signatures of avalanching systems. Here we show how the average avalanche shape evolves with the universality class of the avalanche dynamics by employing a combination of scaling theory, extensive numerical simulations and data from crack propagation experiments. It follows a simple scaling form parameterized by two numbers, the scaling exponent relating the average avalanche size to its duration and a parameter characterizing the temporal asymmetry of the avalanches. The latter reflects a broken time-reversal symmetry in the avalanche dynamics, emerging from the local nature of the interaction kernel mediating the avalanche dynamics.
The Health Effects of Income Inequality: Averages and Disparities.
Truesdale, Beth C; Jencks, Christopher
2016-01-01
Much research has investigated the association of income inequality with average life expectancy, usually finding negative correlations that are not very robust. A smaller body of work has investigated socioeconomic disparities in life expectancy, which have widened in many countries since 1980. These two lines of work should be seen as complementary because changes in average life expectancy are unlikely to affect all socioeconomic groups equally. Although most theories imply long and variable lags between changes in income inequality and changes in health, empirical evidence is confined largely to short-term effects. Rising income inequality can affect individuals in two ways. Direct effects change individuals' own income. Indirect effects change other people's income, which can then change a society's politics, customs, and ideals, altering the behavior even of those whose own income remains unchanged. Indirect effects can thus change both average health and the slope of the relationship between individual income and health.
PROMIS series. Volume 8: Midlatitude ground magnetograms
Fairfield, D. H.; Russell, C. T.
1990-01-01
This is the eighth in a series of volumes pertaining to the Polar Region Outer Magnetosphere International Study (PROMIS). This volume contains 24 hour stack plots of 1-minute average, H and D component, ground magnetograms for the period March 10 through June 16, 1986. Nine midlatitude ground stations were selected from the UCLA magnetogram data base that was constructed from all available digitized magnetogram stations. The primary purpose of this publication is to allow users to define universal times and onset longitudes of magnetospheric substorms.
DISTRIBUTION OF RIVER RUNOFF AND ITS CLIMATE FACTORS IN AVERAGE AND EXTREME YEARS
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Vladimir Konovalov
2011-01-01
Full Text Available Schematic maps of spatial distribution of seasonal precipitation amounts and average air temperatures were obtained for the areas studied in years with normal and extreme values of annual river runoff. Data on precipitation for January–December (I–XII and on average air temperatures for June–September (VI–IX during 1961–1990 collected at 93 meteorological stations located along 30.20°–44.08°N and 67.20°–82.98°E, altitude 122–4 169 m above sea level, were used in the maps’ compilation. For each point-element (i.e. a meteorological station with proper data, the ordinates of an integral empirical function of distribution of probabilities P were calculated from these data for a 30-year sample period and for each year were received average values and standard deviations of P. In characteristic years were revealed, significant differences of spatial distribution of climatic factors and runoff. It was found out also that the spatial distribution of the total volume of glaciers melting is less variable in the years with extreme water yields compared to the average years. This peculiarity is very beneficial for hydropower and agriculture sectors because it provides additional natural ability to stabilize water balance of reservoirs. Piecewise multi-factor linear equations were obtained to calculate the statistical probability of glaciers’ total melting in low and high flow years as a function of geographical coordinates and the average altitude of firn boundary.
Liu, Yao; Galárraga, Omar
2017-03-01
The efficacy of low- and middle-income countries’ (LMIC) national drug policies in managing antiretroviral (ARV) pharmaceutical prices is not well understood. Though ARV drug prices have been declining in LMIC over the past decade, little research has been done on the role of their national drug policies. This study aims to (i) analyse global ARV prices from 2004 to 2013 and (ii) examine the relationship of national drug policies to ARV prices. Analysis of ARV drug prices utilized data from the Global Price Reporting Mechanism from the World Health Organization (WHO). Ten of the most common ARV drugs (first-line and second-line) were selected. National drug policies were also assessed for 12 countries in the South African Development Community (SADC), which self-reported their policies through WHO surveys. The best predictor of ARV drug price was generic status—the generic versions of 8 out of 10 ARV drugs were priced lower than branded versions. However, other factors such as transaction volume, HIV prevalence, national drug policies and PEPFAR/CHAI involvement were either not associated with ARV drug price or were not consistent predictors of price across different ARV drugs. In the context of emerging international trade agreements, which aim to strengthen patent protections internationally and potentially delay the sale of generic drugs in LMIC, this study shines a spotlight on the importance of generic drugs in controlling ARV prices. Further research is needed to understand the impact of national drug policies on ARV prices.
The role of nanobiotechnology in drug discovery.
Jain, Kewal K
2009-01-01
The potential applications of nanotechnology in life sciences, particularly nanobiotechnology, include those for drug discovery. This chapter shows how several of the nanotechnologies including nanoparticles and various nanodevices such as nanobiosensors and nanobiochips are being used to improve drug discovery. Nanoscale assays using nanoliter volumes contribute to cost saving. Some nanosubstances such as fullerenes are drug candidates. There are some safety concerns about the in vivo use of nanoparticles that are being investigated. However, future prospects for applications in healthcare of drugs discovered through nanotechnology and their role in the development of personalized medicine appear to be excellent.
The Role of the Harmonic Vector Average in Motion Integration
Directory of Open Access Journals (Sweden)
Alan eJohnston
2013-10-01
Full Text Available The local speeds of object contours vary systematically with the cosine of the angle between the normal component of the local velocity and the global object motion direction. An array of Gabor elements whose speed changes with local spatial orientation in accordance with this pattern can appear to move as a single surface. The apparent direction of motion of plaids and Gabor arrays has variously been proposed to result from feature tracking, vector addition and vector averaging in addition to the geometrically correct global velocity as indicated by the intersection of constraints (IOC solution. Here a new combination rule, the harmonic vector average (HVA, is introduced, as well as a new algorithm for computing the IOC solution. The vector sum can be discounted as an integration strategy as it increases with the number of elements. The vector average over local vectors that vary in direction always provides an underestimate of the true global speed. The harmonic vector average however provides the correct global speed and direction for an unbiased sample of local velocities with respect to the global motion direction, as is the case for a simple closed contour. The HVA over biased samples provides an aggregate velocity estimate that can still be combined through an IOC computation to give an accurate estimate of the global velocity, which is not true of the vector average. Psychophysical results for type II Gabor arrays show perceived direction and speed falls close to the intersection of constraints direction for Gabor arrays having a wide range of orientations but the IOC prediction fails as the mean orientation shifts away from the global motion direction and the orientation range narrows. In this case perceived velocity generally defaults to the harmonic vector average.
Bioavailability and Bioequivalence in Drug Development.
Chow, Shein-Chung
2014-01-01
Bioavailability is referred to as the extent and rate to which the active drug ingredient or active moiety from the drug product is absorbed and becomes available at the site of drug action. The relative bioavailability in terms of the rate and extent of drug absorption is considered predictive of clinical outcomes. In 1984, the United States Food and Drug Administration (FDA) was authorized to approve generic drug products under the Drug Price Competition and Patent Term Restoration Act based on evidence of average bioequivalence in drug absorption through the conduct of bioavailability and bioequivalence studies. This article provides an overview (from an American point of view) of definition of bioavailability and bioequivalence, Fundamental Bioequivalence Assumption, regulatory requirements, and process for bioequivalence assessment of generic drug products. Basic considerations including criteria, study design, power analysis for sample size determination, and the conduct of bioequivalence trial, and statistical methods are provided. Practical issues such as one size-fits-all criterion, drug interchangeability and scaled average criteria for assessment of highly variable drug products are also discussed.
Measurement of the average lifetime of b hadrons
Adriani, O.; Aguilar-Benitez, M.; Ahlen, S.; Alcaraz, J.; Aloisio, A.; Alverson, G.; Alviggi, M. G.; Ambrosi, G.; An, Q.; Anderhub, H.; Anderson, A. L.; Andreev, V. P.; Angelescu, T.; Antonov, L.; Antreasyan, D.; Arce, P.; Arefiev, A.; Atamanchuk, A.; Azemoon, T.; Aziz, T.; Baba, P. V. K. S.; Bagnaia, P.; Bakken, J. A.; Ball, R. C.; Banerjee, S.; Bao, J.; Barillère, R.; Barone, L.; Baschirotto, A.; Battiston, R.; Bay, A.; Becattini, F.; Bechtluft, J.; Becker, R.; Becker, U.; Behner, F.; Behrens, J.; Bencze, Gy. L.; Berdugo, J.; Berges, P.; Bertucci, B.; Betev, B. L.; Biasini, M.; Biland, A.; Bilei, G. M.; Bizzarri, R.; Blaising, J. J.; Bobbink, G. J.; Bock, R.; Böhm, A.; Borgia, B.; Bosetti, M.; Bourilkov, D.; Bourquin, M.; Boutigny, D.; Bouwens, B.; Brambilla, E.; Branson, J. G.; Brock, I. C.; Brooks, M.; Bujak, A.; Burger, J. D.; Burger, W. J.; Busenitz, J.; Buytenhuijs, A.; Cai, X. D.; Capell, M.; Caria, M.; Carlino, G.; Cartacci, A. M.; Castello, R.; Cerrada, M.; Cesaroni, F.; Chang, Y. H.; Chaturvedi, U. K.; Chemarin, M.; Chen, A.; Chen, C.; Chen, G.; Chen, G. M.; Chen, H. F.; Chen, H. S.; Chen, M.; Chen, W. Y.; Chiefari, G.; Chien, C. Y.; Choi, M. T.; Chung, S.; Civinini, C.; Clare, I.; Clare, R.; Coan, T. E.; Cohn, H. O.; Coignet, G.; Colino, N.; Contin, A.; Costantini, S.; Cotorobai, F.; Cui, X. T.; Cui, X. Y.; Dai, T. S.; D'Alessandro, R.; de Asmundis, R.; Degré, A.; Deiters, K.; Dénes, E.; Denes, P.; DeNotaristefani, F.; Dhina, M.; DiBitonto, D.; Diemoz, M.; Dimitrov, H. R.; Dionisi, C.; Ditmarr, M.; Djambazov, L.; Dova, M. T.; Drago, E.; Duchesneau, D.; Duinker, P.; Duran, I.; Easo, S.; El Mamouni, H.; Engler, A.; Eppling, F. J.; Erné, F. C.; Extermann, P.; Fabbretti, R.; Fabre, M.; Falciano, S.; Fan, S. J.; Fackler, O.; Fay, J.; Felcini, M.; Ferguson, T.; Fernandez, D.; Fernandez, G.; Ferroni, F.; Fesefeldt, H.; Fiandrini, E.; Field, J. H.; Filthaut, F.; Fisher, P. H.; Forconi, G.; Fredj, L.; Freudenreich, K.; Friebel, W.; Fukushima, M.; Gailloud, M.; Galaktionov, Yu.; Gallo, E.; Ganguli, S. N.; Garcia-Abia, P.; Gele, D.; Gentile, S.; Gheordanescu, N.; Giagu, S.; Goldfarb, S.; Gong, Z. F.; Gonzalez, E.; Gougas, A.; Goujon, D.; Gratta, G.; Gruenewald, M.; Gu, C.; Guanziroli, M.; Guo, J. K.; Gupta, V. K.; Gurtu, A.; Gustafson, H. R.; Gutay, L. J.; Hangarter, K.; Hartmann, B.; Hasan, A.; Hauschildt, D.; He, C. F.; He, J. T.; Hebbeker, T.; Hebert, M.; Hervé, A.; Hilgers, K.; Hofer, H.; Hoorani, H.; Hu, G.; Hu, G. Q.; Ille, B.; Ilyas, M. M.; Innocente, V.; Janssen, H.; Jezequel, S.; Jin, B. N.; Jones, L. W.; Josa-Mutuberria, I.; Kasser, A.; Khan, R. A.; Kamyshkov, Yu.; Kapinos, P.; Kapustinsky, J. S.; Karyotakis, Y.; Kaur, M.; Khokhar, S.; Kienzle-Focacci, M. N.; Kim, J. K.; Kim, S. C.; Kim, Y. G.; Kinnison, W. W.; Kirkby, A.; Kirkby, D.; Kirsch, S.; Kittel, W.; Klimentov, A.; Klöckner, R.; König, A. C.; Koffeman, E.; Kornadt, O.; Koutsenko, V.; Koulbardis, A.; Kraemer, R. W.; Kramer, T.; Krastev, V. R.; Krenz, W.; Krivshich, A.; Kuijten, H.; Kumar, K. S.; Kunin, A.; Landi, G.; Lanske, D.; Lanzano, S.; Lebedev, A.; Lebrun, P.; Lecomte, P.; Lecoq, P.; Le Coultre, P.; Lee, D. M.; Lee, J. S.; Lee, K. Y.; Leedom, I.; Leggett, C.; Le Goff, J. M.; Leiste, R.; Lenti, M.; Leonardi, E.; Li, C.; Li, H. T.; Li, P. J.; Liao, J. Y.; Lin, W. T.; Lin, Z. Y.; Linde, F. L.; Lindemann, B.; Lista, L.; Liu, Y.; Lohmann, W.; Longo, E.; Lu, Y. S.; Lubbers, J. M.; Lübelsmeyer, K.; Luci, C.; Luckey, D.; Ludovici, L.; Luminari, L.; Lustermann, W.; Ma, J. M.; Ma, W. G.; MacDermott, M.; Malik, R.; Malinin, A.; Maña, C.; Maolinbay, M.; Marchesini, P.; Marion, F.; Marin, A.; Martin, J. P.; Martinez-Laso, L.; Marzano, F.; Massaro, G. G. G.; Mazumdar, K.; McBride, P.; McMahon, T.; McNally, D.; Merk, M.; Merola, L.; Meschini, M.; Metzger, W. J.; Mi, Y.; Mihul, A.; Mills, G. B.; Mir, Y.; Mirabelli, G.; Mnich, J.; Möller, M.; Monteleoni, B.; Morand, R.; Morganti, S.; Moulai, N. E.; Mount, R.; Müller, S.; Nadtochy, A.; Nagy, E.; Napolitano, M.; Nessi-Tedaldi, F.; Newman, H.; Neyer, C.; Niaz, M. A.; Nippe, A.; Nowak, H.; Organtini, G.; Pandoulas, D.; Paoletti, S.; Paolucci, P.; Pascale, G.; Passaleva, G.; Patricelli, S.; Paul, T.; Pauluzzi, M.; Paus, C.; Pauss, F.; Pei, Y. J.; Pensotti, S.; Perret-Gallix, D.; Perrier, J.; Pevsner, A.; Piccolo, D.; Pieri, M.; Piroué, P. A.; Plasil, F.; Plyaskin, V.; Pohl, M.; Pojidaev, V.; Postema, H.; Qi, Z. D.; Qian, J. M.; Qureshi, K. N.; Raghavan, R.; Rahal-Callot, G.; Rancoita, P. G.; Rattaggi, M.; Raven, G.; Razis, P.; Read, K.; Ren, D.; Ren, Z.; Rescigno, M.; Reucroft, S.; Ricker, A.; Riemann, S.; Riemers, B. C.; Riles, K.; Rind, O.; Rizvi, H. A.; Ro, S.; Rodriguez, F. J.; Roe, B. P.; Röhner, M.; Romero, L.; Rosier-Lees, S.; Rosmalen, R.; Rosselet, Ph.; van Rossum, W.; Roth, S.; Rubbia, A.; Rubio, J. A.; Rykaczewski, H.; Sachwitz, M.; Salicio, J.; Salicio, J. M.; Sanders, G. S.; Santocchia, A.; Sarakinos, M. S.; Sartorelli, G.; Sassowsky, M.; Sauvage, G.; Schegelsky, V.; Schmitz, D.; Schmitz, P.; Schneegans, M.; Schopper, H.; Schotanus, D. J.; Shotkin, S.; Schreiber, H. J.; Shukla, J.; Schulte, R.; Schulte, S.; Schultze, K.; Schwenke, J.; Schwering, G.; Sciacca, C.; Scott, I.; Sehgal, R.; Seiler, P. G.; Sens, J. C.; Servoli, L.; Sheer, I.; Shen, D. Z.; Shevchenko, S.; Shi, X. R.; Shumilov, E.; Shoutko, V.; Son, D.; Sopczak, A.; Soulimov, V.; Spartiotis, C.; Spickermann, T.; Spillantini, P.; Starosta, R.; Steuer, M.; Stickland, D. P.; Sticozzi, F.; Stone, H.; Strauch, K.; Stringfellow, B. C.; Sudhakar, K.; Sultanov, G.; Sun, L. Z.; Susinno, G. F.; Suter, H.; Swain, J. D.; Syed, A. A.; Tang, X. W.; Taylor, L.; Terzi, G.; Ting, Samuel C. C.; Ting, S. M.; Tonutti, M.; Tonwar, S. C.; Tóth, J.; Tsaregorodtsev, A.; Tsipolitis, G.; Tully, C.; Tung, K. L.; Ulbricht, J.; Urbán, L.; Uwer, U.; Valente, E.; Van de Walle, R. T.; Vetlitsky, I.; Viertel, G.; Vikas, P.; Vikas, U.; Vivargent, M.; Vogel, H.; Vogt, H.; Vorobiev, I.; Vorobyov, A. A.; Vuilleumier, L.; Wadhwa, M.; Wallraff, W.; Wang, C.; Wang, C. R.; Wang, X. L.; Wang, Y. F.; Wang, Z. M.; Warner, C.; Weber, A.; Weber, J.; Weill, R.; Wenaus, T. J.; Wenninger, J.; White, M.; Willmott, C.; Wittgenstein, F.; Wright, D.; Wu, S. X.; Wynhoff, S.; Wysłouch, B.; Xie, Y. Y.; Xu, J. G.; Xu, Z. Z.; Xue, Z. L.; Yan, D. S.; Yang, B. Z.; Yang, C. G.; Yang, G.; Ye, C. H.; Ye, J. B.; Ye, Q.; Yeh, S. C.; Yin, Z. W.; You, J. M.; Yunus, N.; Yzerman, M.; Zaccardelli, C.; Zaitsev, N.; Zemp, P.; Zeng, M.; Zeng, Y.; Zhang, D. H.; Zhang, Z. P.; Zhou, B.; Zhou, G. J.; Zhou, J. F.; Zhu, R. Y.; Zichichi, A.; van der Zwaan, B. C. C.; L3 Collaboration
1993-11-01
The average lifetime of b hadrons has been measured using the L3 detector at LEP, running at √ s ≈ MZ. A b-enriched sample was obtained from 432538 hadronic Z events collected in 1990 and 1991 by tagging electrons and muons from semileptonic b hadron decays. From maximum likelihood fits to the electron and muon impact parameter distributions, the average b hadron lifetime was measured to be τb = (1535 ± 35 ± 28) fs, where the first error is statistical and the second includes both the experimental and the theoretical systematic uncertainties.
Calculations of canonical averages from the grand canonical ensemble.
Kosov, D S; Gelin, M F; Vdovin, A I
2008-02-01
Grand canonical and canonical ensembles become equivalent in the thermodynamic limit, but when the system size is finite the results obtained in the two ensembles deviate from each other. In many important cases, the canonical ensemble provides an appropriate physical description but it is often much easier to perform the calculations in the corresponding grand canonical ensemble. We present a method to compute averages in the canonical ensemble based on calculations of the expectation values in the grand canonical ensemble. The number of particles, which is fixed in the canonical ensemble, is not necessarily the same as the average number of particles in the grand canonical ensemble.
Averaging in Parametrically Excited Systems – A State Space Formulation
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Pfau Bastian
2016-01-01
Full Text Available Parametric excitation can lead to instabilities as well as to an improved stability behavior, depending on whether a parametric resonance or anti-resonance is induced. In order to calculate the stability domains and boundaries, the method of averaging is applied. The problem is reformulated in state space representation, which allows a general handling of the averaging method especially for systems with non-symmetric system matrices. It is highlighted that this approach can enhance the first order approximation significantly. Two example systems are investigated: a generic mechanical system and a flexible rotor in journal bearings with adjustable geometry.
HAT AVERAGE MULTIRESOLUTION WITH ERROR CONTROL IN 2-D
Institute of Scientific and Technical Information of China (English)
Sergio Amat
2004-01-01
Multiresolution representations of data are a powerful tool in data compression. For a proper adaptation to the singularities, it is crucial to develop nonlinear methods which are not based on tensor product. The hat average framework permets develop adapted schemes for all types of singularities. In contrast with the wavelet framework these representations cannot be considered as a change of basis, and the stability theory requires different considerations. In this paper, non separable two-dimensional hat average multiresolution processing algorithms that ensure stability are introduced. Explicit error bounds are presented.
Generalized Sampling Series Approximation of Random Signals from Local Averages
Institute of Scientific and Technical Information of China (English)
SONG Zhanjie; HE Gaiyun; YE Peixin; YANG Deyun
2007-01-01
Signals are often of random character since they cannot bear any information if they are predictable for any time t, they are usually modelled as stationary random processes. On the other hand, because of the inertia of the measurement apparatus, measured sampled values obtained in practice may not be the precise value of the signal X(t) at time tk( k∈ Z), but only local averages of X(t) near tk. In this paper, it is presented that a wide (or weak ) sense stationary stochastic process can be approximated by generalized sampling series with local average samples.
THEORETICAL CALCULATION OF THE RELATIVISTIC SUBCONFIGURATION-AVERAGED TRANSITION ENERGIES
Institute of Scientific and Technical Information of China (English)
张继彦; 杨向东; 杨国洪; 张保汉; 雷安乐; 刘宏杰; 李军
2001-01-01
A method for calculating the average energies of relativistic subconfigurations in highly ionized heavy atoms has been developed in the framework of the multiconfigurational Dirac-Fock theory. The method is then used to calculate the average transition energies of the spin-orbit-split 3d-4p transition of Co-like tungsten, the 3d-5f transition of Cu-like tantalum, and the 3d-5f transitions of Cu-like and Zn-like gold samples. The calculated results are in good agreement with those calculated with the relativistic parametric potential method and also with the experimental results.
Quantum state discrimination using the minimum average number of copies
Slussarenko, Sergei; Li, Jun-Gang; Campbell, Nicholas; Wiseman, Howard M; Pryde, Geoff J
2016-01-01
In the task of discriminating between nonorthogonal quantum states from multiple copies, the key parameters are the error probability and the resources (number of copies) used. Previous studies have considered the task of minimizing the average error probability for fixed resources. Here we consider minimizing the average resources for a fixed admissible error probability. We derive a detection scheme optimized for the latter task, and experimentally test it, along with schemes previously considered for the former task. We show that, for our new task, our new scheme outperforms all previously considered schemes.
Average quantum dynamics of closed systems over stochastic Hamiltonians
Yu, Li
2011-01-01
We develop a master equation formalism to describe the evolution of the average density matrix of a closed quantum system driven by a stochastic Hamiltonian. The average over random processes generally results in decoherence effects in closed system dynamics, in addition to the usual unitary evolution. We then show that, for an important class of problems in which the Hamiltonian is proportional to a Gaussian random process, the 2nd-order master equation yields exact dynamics. The general formalism is applied to study the examples of a two-level system, two atoms in a stochastic magnetic field and the heating of a trapped ion.
MAIN STAGES SCIENTIFIC AND PRODUCTION MASTERING THE TERRITORY AVERAGE URAL
Directory of Open Access Journals (Sweden)
V.S. Bochko
2006-09-01
Full Text Available Questions of the shaping Average Ural, as industrial territory, on base her scientific study and production mastering are considered in the article. It is shown that studies of Ural resources and particularities of the vital activity of its population were concerned by Russian and foreign scientist in XVIII-XIX centuries. It is noted that in XX century there was a transition to systematic organizing-economic study of production power, society and natures of Average Ural. More attention addressed on new problems of region and on needs of their scientific solving.
Precision volume measurement system.
Energy Technology Data Exchange (ETDEWEB)
Fischer, Erin E.; Shugard, Andrew D.
2004-11-01
A new precision volume measurement system based on a Kansas City Plant (KCP) design was built to support the volume measurement needs of the Gas Transfer Systems (GTS) department at Sandia National Labs (SNL) in California. An engineering study was undertaken to verify or refute KCP's claims of 0.5% accuracy. The study assesses the accuracy and precision of the system. The system uses the ideal gas law and precise pressure measurements (of low-pressure helium) in a temperature and computer controlled environment to ratio a known volume to an unknown volume.
Glucksberg, H; Singer, J
1982-01-01
An analysis of the types and costs of drugs imported by seven multinational pharmaceutical companies in Zaire, an underdeveloped country in Africa, reveals that three-fourths of the drugs consisted of expensive and nonessential items. The prices of essential drugs (24 percent of their total imports) were much higher than those of available generic sources (average difference of 300 percent). The importation of nonessential drugs and high prices paid for essential drugs exacerbate the scarcity of needed items because of Zaire's limited supply of hard currency. In addition, two drug firms imported and promoted the sale of aminopyrone-dipyrone analgesic-antipyretics, drugs now rarely used in Western industrialized countries because of potentially fatal complications. Thus, in Zaire, the multinational pharmaceutical industry has an adverse effect on the availability and cost of drugs, as well as on the pattern of drug usage.
Morris, Sara; Michael, Nancy, Ed.
This module on antineoplastic drugs is intended for use in inservice or continuing education programs for persons who administer medications in long-term care facilities. Instructor information, including teaching suggestions, and a listing of recommended audiovisual materials and their sources appear first. The module goal and objectives are then…
Full Text Available ... Phone Numbers and Websites Search Share Listen English Español Information about this page Click on the button ... sobre el abuso de drogas, y adicción. English Español About the National Institute on Drug Abuse (NIDA) | ...
Directory of Open Access Journals (Sweden)
R. Balsamo
2010-06-01
Full Text Available Mucus hypersecretion is a clinical feature of severe respiratory diseases such as asthma, cystic fibrosis and chronic obstructive pulmonary disease. Airway mucosal infection and/or inflammation associated with these diseases often gives rise to inflammatory products, including neutrophil-derived DNA and filamentous actin, in addition to bacteria, apoptotic cells and cellular debris, that may collectively increase mucus production and viscosity. Mucoactive agents have been the medication of choice for the treatment of respiratory diseases in which mucus hypersecretion is a clinical complication. The main purpose of mucoactive drugs is to increase the ability to expectorate sputum and/or decrease mucus hypersecretion. Many mucoactive drugs are currently available and can be classified according to their putative mechanism of action. Mucoactive medications include expectorants, mucoregulators, mucolytics and mucokinetics. By developing our understanding of the specific effects of mucoactive agents, we may result in improved therapeutic use of these drugs. The present review provides a summary of the most clinically relevant mucoactive drugs in addition to their potential mechanism of action.
Full Text Available ... Prevention Phone Numbers and Websites Search Share Listen English Español Information about this page Click on the ... información sobre el abuso de drogas, y adicción. English Español About the National Institute on Drug Abuse ( ...
Gorter, J.A.; Potschka, H.; Noebels, J.L.; Avoli, M.; Rogawski, M.A.; Olsen, R.W.; Delgado-Escueta, A.V.
2012-01-01
Drug resistance remains to be one of the major challenges in epilepsy therapy. Identification of factors that contribute to therapeutic failure is crucial for future development of novel therapeutic strategies for difficult-to-treat epilepsies. Several clinical studies have shown that high seizure f
High Drug Prices Hurt Everyone
Halpenny, Genevieve M.
2016-01-01
Turing Pharmaceuticals raised the price of Daraprim 5,500%, illustrating how the absence of competition in the sale of low-volume, low-price drugs can lead to price gouging. For patented medicines, society allows supracompetitive pricing to incentivize innovation. However, Gilead���s decision to sell Sovaldi for $84,000 per course of treatment raised the question whether society must accept any price set by the patent holder. Unfortunately, these incidents illustrate a br...
Evaluation of Average Wall Thickness of Organically Modified Mesoporous Silica
Institute of Scientific and Technical Information of China (English)
Yan Jun GONG; Zhi Hong LI; Bao Zhong DONG
2005-01-01
The small angle X-ray scattering of organically modified MSU-X silica prepared by co-condensation of tetraethoxysilane (TEOS) and methyltriethoxysilane (MTES) show negative deviation from Debye's theory due to the existence of the organic interface layer. By exerting correction of the scattering negative deviation, Debye relation may be recovered, and the average wall thickness of the material may be evaluated.
Climate Prediction Center (CPC) Zonally Average 500 MB Temperature Anomalies
National Oceanic and Atmospheric Administration, Department of Commerce — This is one of the CPC?s Monthly Atmospheric and SST Indices. It is the 500-hPa temperature anomalies averaged over the latitude band 20oN ? 20oS. The anomalies are...
Error estimates in horocycle averages asymptotics: challenges from string theory
Cardella, M.A.
2010-01-01
For modular functions of rapid decay, a classical result connects the error estimate in their long horocycle average asymptotic to the Riemann hypothesis. We study similar asymptotics, for modular functions with not that mild growing conditions, such as of polynomial growth and of exponential growth
75 FR 78157 - Farmer and Fisherman Income Averaging
2010-12-15
... computing income tax liability. The regulations reflect changes made by the American Jobs Creation Act of 2004 and the Tax Extenders and Alternative Minimum Tax Relief Act of 2008. The regulations provide...) relating to the averaging of farm and fishing income in computing tax liability. A notice of proposed...
The First Steps with Alexia, the Average Lexicographic Value
Tijs, S.H.
2005-01-01
The new value AL for balanced games is discussed, which is based on averaging of lexicographic maxima of the core.Exactifications of games play a special role to find interesting relations of AL with other solution concepts for various classes of games as convex games, big boss games, simplex games