WorldWideScience

Sample records for volume 2-l st

  1. The role of IL-33/ST2L signals in the immune cells.

    Science.gov (United States)

    Lu, Jingli; Kang, Jian; Zhang, Chengliang; Zhang, Xiaojian

    2015-03-01

    Interleukin (IL)-33 signals influence various immune cells during differentiation, immune responses and homeostasis. As discussed in this Review, IL-33 via TI/ST2L regulates the functions of immune cells including T cells, B cells, DCs, macrophages, mast cells, and innate lymphoid cells (ILCs). Stimulation with IL-33 is crucial for CD4+ T cell polarized into Th2 immunity and for the induction of Treg. CD8+ T cells can also express ST2L and IL-33 promotes features of effector CD8+ T cells. For macrophages and ILCs, ST2L presents on these cells and IL-33 induces Th2 cytokine production. IL-33 modulates adhesion, activation, maturation, and cytokine production by mast cells. ST2 is expressed in B1 and is important for differentiation of IL-10-producing B cells. Understanding the specific role of IL-33/ST2L in different immune cells will help to answer the remaining questions that are important for diseases pathologies and intervention strategies by targeting the IL-33/ST2L signals.

  2. Interleukin-33 enhances programmed oncosis of ST2L-positive low-metastatic cells in the tumour microenvironment of lung cancer

    OpenAIRE

    2016-01-01

    The proinflammatory interleukin-33 (IL-33) binds to its receptor ST2L on the surface of immune cells and stimulates the production of Th2 cytokines; however, the effects of IL-33 on tumour cells are poorly understood. Here we show that ST2 was significantly downregulated in human lung cancer tissues and cells compared with normal lung tissues and cells. IL-33 expression was also inversely correlated with the stages of human lung cancers. In accordance with this finding, low-metastatic cells b...

  3. Environmental Contaminants Evaluation of St. Andrew Bay, Florida: Volume 1

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Between 1985 and 1997, a general survey of St. Andrew Bay, Florida, was conducted to measure chemical contaminant concentrations in the sediments and selected biota....

  4. Technology Directions for the 21st Century, volume 1

    Science.gov (United States)

    Crimi, Giles F.; Verheggen, Henry; McIntosh, William; Botta, Robert

    1996-01-01

    For several decades, semiconductor device density and performance have been doubling about every 18 months (Moore's Law). With present photolithography techniques, this rate can continue for only about another 10 years. Continued improvement will need to rely on newer technologies. Transition from the current micron range for transistor size to the nanometer range will permit Moore's Law to operate well beyond 10 years. The technologies that will enable this extension include: single-electron transistors; quantum well devices; spin transistors; and nanotechnology and molecular engineering. Continuation of Moore's Law will rely on huge capital investments for manufacture as well as on new technologies. Much will depend on the fortunes of Intel, the premier chip manufacturer, which, in turn, depend on the development of mass-market applications and volume sales for chips of higher and higher density. The technology drivers are seen by different forecasters to include video/multimedia applications, digital signal processing, and business automation. Moore's Law will affect NASA in the areas of communications and space technology by reducing size and power requirements for data processing and data fusion functions to be performed onboard spacecraft. In addition, NASA will have the opportunity to be a pioneering contributor to nanotechnology research without incurring huge expenses.

  5. The Defense Science Board 1999 Summer Study Task Force on 21st Century Defense Technology Strategies. Volume 1

    Science.gov (United States)

    2016-06-07

    Study Task Force On 21ST Century Defense Technology Strategies Volume 1 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR...3. Defense Technology Strategy and Management PART 4. Strategic Agility PART 5. Analysis and Quantitative Results iii PREFACE The Defense Science...Board (DSB) 1999 Summer Study Task Force on 21st Century Defense Technology Strategies continues a series of studies that have examined key challenges

  6. The relation between 1st grade grey matter volume and 2nd grade math competence.

    Science.gov (United States)

    Price, Gavin R; Wilkey, Eric D; Yeo, Darren J; Cutting, Laurie E

    2016-01-01

    Mathematical and numerical competence is a critical foundation for individual success in modern society yet the neurobiological sources of individual differences in math competence are poorly understood. Neuroimaging research over the last decade suggests that neural mechanisms in the parietal lobe, particularly the intraparietal sulcus (IPS) are structurally aberrant in individuals with mathematical learning disabilities. However, whether those same brain regions underlie individual differences in math performance across the full range of math abilities is unknown. Furthermore, previous studies have been exclusively cross-sectional, making it unclear whether variations in the structure of the IPS are caused by or consequences of the development of math skills. The present study investigates the relation between grey matter volume across the whole brain and math competence longitudinally in a representative sample of 50 elementary school children. Results show that grey matter volume in the left IPS at the end of 1st grade relates to math competence a year later at the end of 2nd grade. Grey matter volume in this region did not change over that year, and was still correlated with math competence at the end of 2nd grade. These findings support the hypothesis that the IPS and its associated functions represent a critical foundation for the acquisition of mathematical competence.

  7. Proceedings of the 21st DOE/NRC nuclear air cleaning conference; Volume 2, Sessions 9--16

    Energy Technology Data Exchange (ETDEWEB)

    First, M.W. [ed.] [Harvard Univ., Boston, MA (United States). Harvard Air Cleaning Lab.

    1991-02-01

    The 21st meeting of the Department of Energy/Nuclear Regulatory Commission (DOE/NRC) Nuclear Air Cleaning Conference was held in San Diego, CA on August 13--16, 1990. The proceedings have been published as a two volume set. Volume 2 contains sessions covering adsorbents, nuclear codes and standards, modelling, filters, safety, containment venting and a review of nuclear air cleaning programs around the world. Also included is the list of attendees and an index of authors and speakers. (MHB)

  8. Great Lakes and St. Lawrence Seaway Navigation Season Extension. Volume 2. Appendixes A - B

    Science.gov (United States)

    1979-08-01

    can be divided into three sections. The lower section, from Montreal at the Jacques Cartier bridge to the mouth of the St. Regis River, is 73 miles long...walls with a co- polymer couiting and removing the ice that does adhere by using portable steam hoses with nozzles would handle the general lock wall...periods when there are no vessels and as a flusher only during locking cycles. Also, a co- polymer coating would be applied to the gate and gate recess 9:o

  9. Libraries in the early 21st century, volume 1 An international perspective

    CERN Document Server

    Sharma, Ravindra

    2012-01-01

    This unique volume gives a truly international overview over the modern history and development of libraries and library technology in selected countries of the world. The careful selection of countries achieves good representation of library work on all continents, covering examples of both the developed and the developing world. A further volume with further national profiles is planned for 2012. This multivolume work represents an excellent contribution to international librarianship and allows comparative studies both at graduate and professional level. Many of the contributors are well-kn

  10. Water resources data, Ohio: Water year 1991. Volume 2, St. Lawrence River Basin: Statewide project data

    Energy Technology Data Exchange (ETDEWEB)

    Shindel, H.L.; Klingler, J.H.; Mangus, J.P.; Trimble, L.E.

    1992-03-01

    The Water Resources Division of the US Geological Survey (USGS), in cooperation with State agencies, obtains a large amount of data pertaining to the water resources of Ohio each water year. These data, accumulated during many years, constitute a valuable data base for developing an improved understanding of the water resources of the State. To make these data readily available to interested parties outside the USGS, the data are published annually in this report series entitled ``Water Resources Data--Ohio.`` This report (in two volumes) includes records on surface water and ground water in the State. Specifically, it contains: (1) Discharge records for 131 streamflow-gaging stations, 95 miscellaneous sites; (2) stage and content records for 5 streams, lakes, and reservoirs; (3) water-quality for 40 streamflow-gaging stations, 378 wells, and 74 partial-record sites; and (4) water levels for 431 observation wells.

  11. The number of circulating CD14+ cells is related to infarct size and postinfarct volumes in ST segment elevation myocardial infarction but not non-ST segment elevation myocardial infarction

    Science.gov (United States)

    Montange, Damien; Davani, Siamak; Deschaseaux, Frédéric; Séronde, Marie France; Chopard, Romain; Schiele, François; Jehl, Jérome; Bassand, Jean Pierre; Kantelip, Jean-Pierre; Meneveau, Nicolas

    2012-01-01

    OBJECTIVE: To determine the relationship between the number of CD14+ cells, myocardial infarct (MI) size and left ventricular (LV) volumes in ST segment elevation MI (STEMI) and non-ST segment elevation MI (NSTEMI) patients. METHODS: A total of 62 patients with STEMI (n=34) or NSTEMI (n=28) were enrolled. The number of CD14+ cells was assessed at admission. Infarct size, left ventricular ejection fraction (LVEF) and LV volumes were measured using magnetic resonance imaging five days after MI and six months after MI. Results: In STEMI patients, the number of CD14+ cells was positively and significantly correlated with infarct size at day 5 (r=0.40; P=0.016) and after six months (r=0.34; P=0.047), negatively correlated with LVEF at day 5 (r=−0.50; P=0.002) and after six months (r=−0.46; P=0.005) and positively correlated with end-diastolic (r=0.38; P=0.02) and end-systolic (r=0.49; P=0.002) volumes after six months. In NSTEMI patients, no significant correlation was found between the number of CD14+ cells and infarct size, LVEF or LV volumes at day 5 or after six months. CONCLUSIONS: The number of CD14+ cells at admission was associated with infarct size and LV remodelling in STEMI patients with large infarct size, whereas in NSTEMI patients, no relationship was observed between numbers of CD14+ cells and LV remodelling. PMID:23620701

  12. Water Resources Investigation. St. Louis Metropolitan Area, Missouri and Illinois. Maline Creek, Missouri Survey Report. Volume 2. Appendices.

    Science.gov (United States)

    1980-09-01

    the extension of Chippewa Street) against a 52-foot Mississippi River flood stage ( Market Street gage). Details regarding the overall city of St. Louis...significantly contribute to outdoor recreation objective by increasing the opportunity for such activities as nature hiking and birdwatching . wildlife...resources related to any proposed project. The changes may be of a market or non- market character, but generally the latter. Such effects are inextricably

  13. Rancang Bangun dan Studi Eksperimen Alat Penukar Panas untuk Memanfaatkan Energi Referigerant Keluar Kompresor AC sebagai Pemanas Air pada ST/D=4 dengan Variasi Volume Air

    Directory of Open Access Journals (Sweden)

    Binar Kusumah Bagja

    2017-01-01

    Full Text Available Sistem referigerasi memiliki energi yang besar dalam melepaskan kalor. Kalor akibat kompresi pada kompresor bisa dimanfaatkan misalnya untuk pemanasan air. Pemanfaatan kalor tersebut dilakukan dengan cara menambahkan water heater sebelum aliran fluida referigeran masuk ke kondensor. Water heater tersebut dalam keadaan tercelup di dalam sebuah tangki berisi air untuk melepas kalor terhadap air. Perancangan water heater dilakukan dengan mencari panjang tube (L, diameter tube (D, dan jarak antar tube. Water Heater ini diletakkan setelah komponen kompressor pada sistem AC. Proses awal untuk mencari rancangan water heater adalah dengan mencari temperatur keluaran kompresor dimana untuk mencari potensi panas yang akan dimanfaatkan untuk memanaskan air. Setelah mencari potensi panas yang dihasilkan dari energi keluaran kompresor adalah mencari kapasitas kalor yang akan diberikan water heater terhadap air dan kemudian selanjutnya mencari perpindahan panas yang terjadi pada proses pemanasan air tersebut yang kemudian dilakukan perhitungan untuk mencari panjang tube (L dan penentuan jarak ST/D pada tube. Setelah diperoleh geometri water heater, langkah selanjutnya adalah melakukan simulasi numerik dengan menggunakan perangkat lunak FLUENT 6.3.2 untuk mengetahui karaketeristik perpindahan panas yang terjadi di dalam proses pemanasan air dengan jarak ST/D yang telah ditentukan sebelumnya. Langkah selanjutnya melakukan eksperimen. Eksperimen dilakukan dengan memvariasikan volume air dalam tangki yaitu sebesar 75 liter; 85 liter; dan 100 liter. Hasil simulasi numerik diperoleh bahwa pola aliran kecepatan dengan nilai tertinggi berada pada daerah sekitaran tube inlet dikarenakan temperatur yang paling tinggi dibandingkan tube lainnya sehingga menimbulkan perbedaan temperatur dan juga densitas pada sekitaran tube inlet. Hasil eksperimen diperoleh bahwa volume air yang besar yaitu sebesar 100 liter memiliki Coefficient of Performance (COP tertinggi yaitu sebesar

  14. Wadter Resources Data Ohio: Water year 1994. Volume 2, St. Lawrence River Basin and Statewide Project Data

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    The Water Resources Division of the US Geological Survey (USGS), in cooperation with State agencies, obtains a large amount of data each water year (a water year is the 12-month period from October 1 through September 30 and is identified by the calendar year in which it ends) pertaining to the water resources of Ohio. These data, accumulated during many years, constitute a valuable data base for developing an improved understanding of the water resources of the State. To make these data readily available to interested parties outside the USGS, they are published annually in this report series entitled ``Water Resources Data--Ohio.`` This report (in two volumes) includes records on surface water and ground water in the State. Specifically, it contains: (1) Discharge records for streamflow-gaging stations, miscellaneous sites, and crest-stage stations; (2) stage and content records for streams, lakes, and reservoirs; (3) water-quality data for streamflow-gaging stations, wells, synaptic sites, and partial-record sites; and (4) water-level data for observation wells. Locations of lake- and streamflow-gaging stations, water-quality stations, and observation wells for which data are presented in this volume are shown in figures ga through 8b. The data in this report represent that part of the National Water Data System collected by the USGS and cooperating State and Federal agencies in Ohio. This series of annual reports for Ohio began with the 1961 water year with a report that contained only data relating to the quantities of surface water. For the 1964 water year, a similar report was introduced that contained only data relating to water quality. Beginning with the 1975 water year, the report was changed to present (in two to three volumes) data on quantities of surface water, quality of surface and ground water, and ground-water levels.

  15. Echocardiographic predictors of early in-hospital heart failure during first ST-elevation acute myocardial infarction: does myocardial performance index and left atrial volume improve diagnosis over conventional parameters of left ventricular function?

    Directory of Open Access Journals (Sweden)

    Machado Cristiano V

    2011-06-01

    Full Text Available Abstract Background Left ventricular ejection fraction (LVEF has been considered a major determinant of early outcome in acute myocardial infarction (AMI. Myocardial performance index (MPI has been associated to early evolution in AMI in a heterogeneous population, including non ST-elevation or previous AMI. Left atrial volume has been related with late evolution after AMI. We evaluated the independent role of clinical and echocardiographic variables including LVEF, MPI and left atrial volume in predicting early in-hospital congestive heart failure (CHF specifically in patients with a first isolated ST-elevation AMI. Methods Echocardiography was performed within 30 hours of chest pain in 95 patients with a first ST-elevation AMI followed during the first week of hospitalization. Several clinical and echocardiographic variables were analyzed. CHF was defined as Killip class ≥ II. Multivariate regression analysis was used to select independent predictor of in-hospital CHF. Results Early in-hospital CHF occurred in 29 (31% of patients. LVEF ≤ 0.45 was the single independent and highly significant predictor of early CHF among other clinical and echocardiographic variables (odds ratio 17.0; [95% CI 4.1 - 70.8]; p Conclusion For patients with first, isolated ST-elevation AMI, LVEF assessed by echocardiography still constitutes a strong and accurate independent predictor of early in-hospital CHF, superior to isolated MPI and left atrial volume in this particular subset of patients.

  16. Continuous emission monitoring for industrial boilers, General Motors Corporation, Assembly Division, St. Louis, Missouri. Volume I. System configuration and results of the operational test period. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Huckabee, D.; Diamond, S.; Porter, T.; McGlew, P.

    1980-06-01

    The objective of this program was to continuously monitor sulfur dioxide (SO/sub 2/) removal efficiencies of a flue gas desulfurization (FGD) system installed an industrial boiler for 30 days. The data will be used to substantiate the applicability of extractive monitors to industrial boilers and to aid in formulating New Source Performance Standards (NSPS) for industrial boilers. The monitoring program was conducted at the General Motors Corporation, Assembly Division, located in St. Louis, Missouri, during the period of December 27, 1979 through March 8, 1980. Sulfur dioxide (SO/sub 2/) and oxygen (O/sub 2/) concentrations were measured on a dry basis concurrently at both the inlet and outlet of the FGD system controlling the exhaust from one coal-fired boiler. Before commencing the monitoring program the analyzers were subjected to draft Performance Specification Tests (PST) delineated in 40 CFR 60 Appendix B, PST 2 and 3 proposed revisions, October 10, 1979. Throughout the 30-day program, abbreviated accuracy tests were conducted for both SO/sub 2/ and O/sub 2/ monitors and complete accuracy tests were conducted at the conclusion of the program. During the 30-day program, three simultaneous Method 5 particulate tests were conducted at the scrubber inlet and outlet. Component failure and electrical problems delayed the start date for monitoring from January 1, 1980 until February 3, 1980. Once these problems were rectified, the conditioning period was completed and the 30 days of data collection was begun. The report is contained in three volumes. Volume I is a compilation of the following: description of the combustion unit; description of the FGD system; description of monitoring data and process data acquisition, and data reduction; description of the monitoring program; description of the PSTs; results and conclusion of the PST and particulate tests; and quality assurance procedures.

  17. Educating about Social Issues in the 20th and 21st Centuries: A Critical Annotated Bibliography. Research in Curriculum and Instruction. Volume 1

    Science.gov (United States)

    Totten, Samuel, Ed.; Pedersen, Jon, Ed.

    2012-01-01

    Educating About Social Issues in the 20th and 21st Centuries: A Critical Annotated Bibliography, is comprised of critical essays accompanied by annotated bibliographies on a host of programs, models, strategies and concerns vis-a-vis teaching and learning about social issues facing society. The primary goal of the book is to provide undergraduate…

  18. PRMT1-mediated arginine methylation controls ATXN2L localization

    Energy Technology Data Exchange (ETDEWEB)

    Kaehler, Christian; Guenther, Anika; Uhlich, Anja; Krobitsch, Sylvia, E-mail: krobitsc@molgen.mpg.de

    2015-05-15

    Arginine methylation is a posttranslational modification that is of importance in diverse cellular processes. Recent proteomic mass spectrometry studies reported arginine methylation of ataxin-2-like (ATXN2L), the paralog of ataxin-2, a protein that is implicated in the neurodegenerative disorder spinocerebellar ataxia type 2. Here, we investigated the methylation state of ATXN2L and its significance for ATXN2L localization. We first confirmed that ATXN2L is asymmetrically dimethylated in vivo, and observed that the nuclear localization of ATXN2L is altered under methylation inhibition. We further discovered that ATXN2L associates with the protein arginine-N-methyltransferase 1 (PRMT1). Finally, we showed that neither mutation of the arginine–glycine-rich motifs of ATXN2L nor methylation inhibition alters ATXN2L localization to stress granules, suggesting that methylation of ATXN2L is probably not mandatory. - Highlights: • ATXN2L is asymmetrically dimethylated in vivo. • ATXN2L interacts with PRMT1 under normal and stress conditions. • PRMT1-mediated dimethylation of ATXN2L controls its nuclear localization. • ATXN2L localization to stress granules appears independent of its methylation state.

  19. Defense Science Board 1996 Summer Study Task Force On Tactics and Technology for 21st Century Military Superiority. Volume 2, Part 1. Supporting Materials

    Science.gov (United States)

    1996-10-01

    Nancy Chesser • Defense Science Board member ** Members Ex Officio Volume 2, Part 1, Conops 1- Leading Edge Strike Force Volume 2, Part 1, Conops 1...the Sense and Destroy Armor (SADARM) Munition (U), RAND, 1995, MR-510-A. Matsumura, J., E. Cardenas , K. Horn, E. McDonald, Future Army Long- Range

  20. Limnological and Fisheries Studies of the St. Marys River, Michigan, in Relation to Proposed Extension of the Navigation Season, 1982 and 1983. Volume 2. Appendices A - P.

    Science.gov (United States)

    1986-01-01

    Koehler, Rick Ligman, Rich O’Neal, Mehdi Siami, and Paul Roettger Department of Fisheries and Wildlife Michigan State University East Lansing, Michigan...2131 I01.0 11. 70.0 3rand Sue 3817 9cmn 11939.0 std.01Y. 497.9 Std.Err z 287.3 6EAR : ECKMAN DENSITIES ( # I SO. M DATE ST4/SITE TAXON REPI REP2 REP3...Std.D.v. * 1677.7 Std.Err : %8.6 .1% SEAR : ECKMAN DENSITIES I I Sg. M DATE STA/SITE TAXON REPI REP2 REP3 MEAN 3td.Dev. St.Err. N 05/26/82 3/A I

  1. Analysis list: Ash2l [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Ash2l Blood + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Ash2l.1.tsv... http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Ash2l.5.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Ash...2l.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Ash2l.Blood.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Blood.gml ...

  2. Investigation and evaluation of geopressured-geothermal wells. Fairfax Foster Sutter No. 2 well, St. Mary Parish, Louisiana. Volume I. Completion and testing. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Willits, M.H.; McCoy, R.L.; Dobson, R.J.; Hartsock, J.H.

    1979-12-01

    The Fairfax Foster Sutter No. 2 well, located in the East Franklin area of St. Mary Parish, Louisiana, is the first successful test of a geopressured-geothermal aquifer under the Well-of-Opportunity program. The section tested was the MA-6 sand of lower Miocene age which has produced large quantities of gas from the adjacent but structurally separated Garden City field. In the subject well the observed temperature was 270{sup 0}F (132{sup 0}C) and the measured gradient was 0.77 psi/ft. The gross sand thickness was 270 feet, the net sand thickness 190 feet, and the tested interval 58 net feet. The temperatures and pressures encountered approached the limits of the surface-recording bottomhole pressure gauge and particularly the single-conductor cables on which the gauges were run. The objectives of the tests were all accomplished, and data were obtained which will contribute to the overall assessment of the geopressured-geothermal resource of the Upper Gulf of Mexico basin. In general, the gas solubility (22.8 scf/bbl) was as expected for the temperature, pressure, and salinity of the brine. The produced water was more saline than expected (160,000 mg/l). The high concentrations of dissolved solids, coupled with the evolution of CO{sub 2} from these waters during production, created a scaling problem in the tubular goods and surface equipment that will have to be addressed in future tests.

  3. St. Lucia.

    Science.gov (United States)

    1987-06-01

    The population of St Lucia was 123,000 in 1986, with an annual growth rate of 2%. The infant mortality rate stands at 22.2/1000 live births, and life expectancy is 70.3 years for males and 74.9 years for females. The literacy rate is 78%. St Lucia's labor force is allocated as follows: agriculture, 36.6%; industry and commerce, 20.1%; and services, 18.1%. The gross national product (GNP) was US$146 million in 1985, with an annual growth rate of 3% and a per capita GNP of $1071. St Lucia is a parliamentary democracy modeled on the British Westminster system. The island is divided into 16 parishes and 1 urban area (the capital, Castries). St Lucia is currently a politically stable country, although the high level of youth unemployment is a cause for concern. Ongoing stability may depend on the government's ability to provide services such as jobs and housing. The economy has evolved from a monocrop sugar plantation type to a diversified economy based on agriculture, industry, and tourism. Agriculture, dominated by the banana industry, is characterized by the participation of a large number of small and medium-sized enterprises. Industry is being encouraged through the provision of incentives such as tax rebates. The government is attempting to maintain a sound investment climate through a tripartite dialogue with the private sector and trade unions. Overall economic policy is predicated on the attraction of sound investments, by both local and foreign entities, to accelerate the rate of economic growth, solve the unemployment problem, and generate a solid balance-of-payments position.

  4. Status of the T2L2/Jason2 Experiment

    Science.gov (United States)

    Exertier, Pierre; Samain, Etienne; Bonnefond, Pascal; Guillemot, Philippe

    2010-12-01

    The T2L2 (Time Transfer by Laser Link) project, developed by CNES and OCA will permit the synchronization of remote ultra stable clocks and the determination of their performances over intercontinental distances. The principle of the experiment derives from Satellite Laser Ranging (SLR) technology with dedicated space equipment. T2L2 was accepted in 2005 to be on board the Jason2 altimetry satellite. The payload consists of both event timer and photo detection modules. The system uses the ultra-stable quartz oscillator of DORIS as on-board reference clock on one hand, and the Laser Reflector Array, making T2L2 a real two-way time transfer system on the other hand. The expected time stability of the T2L2 instrument (detection and timing), referenced by the DORIS oscillator and including all internal error sources should be at the level of 10-12 ps at 1 s and T2L2 should permit to maintain a precision of 1 to a few ps when measuring the phase of a clock during around 1000 seconds. First analysis of T2L2 data permitted to validate some important characteristics of the experiment such as the sensitivity of the instrument to laser pulse amplitude (from single to multi-photon detection mode), data noises (of different sources, SLR and T2L2), and first error budget and time stability of ground to space time transfers. The paper describes the space experiment and highlights the different steps of the data processing after a first year of operations (between July 2008 and June 2009). We show the time stability which can be reached when a laser station is equipped with an Hydrogen Maser or a Cesium clock as a time reference; thus, the first estimations give 7 ps over 30 s. We conclude by presenting the campaigns of ground to ground time transfers already planned between the Paris Observatory and different places in Europe.

  5. St. Louis FUSRAP Lessons Learned

    Energy Technology Data Exchange (ETDEWEB)

    Eberlin, J.; Williams, D.; Mueller, D.

    2003-02-26

    The purpose of this paper is to present lessons learned from fours years' experience conducting Remedial Investigation and Remedial Action activities at the St. Louis Downtown Site (SLDS) under the Formerly Utilized Sites Remedial Action Program (FUSRAP). Many FUSRAP sites are experiencing challenges conducting Remedial Actions within forecasted volume and budget estimates. The St. Louis FUSRAP lessons learned provide insight to options for cost effective remediation at FUSRAP sites. The lessons learned are focused on project planning (budget and schedule), investigation, design, and construction.

  6. (T2L2) Time Transfer by Laser Link

    Science.gov (United States)

    Veillet, Christian; Fridelance, Patricia

    1995-05-01

    T2L2 (Time Transfer by Laser Link) is a new generation time transfer experiment based on the principles of LASSO (Laser Synchronization from Synchronous Orbit) and used with an operational procedure developed at OCA (Observatoire de la Cote d'Azur) during the active intercontinental phase of LASSO. The hardware improvements could lead to a precision better than 10 ps for time transfer (flying clock monitoring or ground based clock comparison). Such a package could fly on any spacecraft with a stable clock. It has been developed in France in the frame of the PHARAO project (cooled atom clock in orbit) involving CNES and different laboratories. But T2L2 could fly on any spacecraft carrying a stable oscillator. A GPS satellite would be a good candidate, as T2L2 could allow to link the flying clock directly to ground clocks using light, aiming to important accuracy checks, both for time and for geodesy. Radioastron (a flying VLBI antenna with a H-maser) is also envisioned, waiting for a PHARAO flight. The ultimate goal of T2L2 is to be part of more ambitious missions, as SORT (Solar Orbit Relativity Test), aiming to examine aspects of the gravitation in the vicinity of the Sun.

  7. Radiative neutrino model with S U (2 )L triplet fields

    Science.gov (United States)

    Nomura, Takaaki; Okada, Hiroshi; Orikasa, Yuta

    2016-12-01

    We propose a loop-induced neutrino mass model, in which we introduce several exotic fermions and bosons with an S U (2 )L multiplet, and discuss various phenomenologies such as lepton flavor violations, the muon anomalous magnetic moment, nonstandard interacting neutrinoless double beta decay, the relic density of dark matter, and the possibility of the spin-independent direct detection searches, imposing the constraints of oblique parameters. And we show a benchmark point to satisfy all the constraints and discuss our predictions.

  8. A Radiative Neutrino Model with $SU(2)_L$ Triplet Fields

    CERN Document Server

    Nomura, Takaaki; Orikasa, Yuta

    2016-01-01

    We propose a loop induced neutrino mass model, in which we introduce several exotic fermions and bosons with $SU(2)_L$ multiplet, and discuss various phenomenologies such as lepton flavor violations, muon anomalous magnetic moment, nonstandard interacting neutrinoless double beta decay, relic density of dark matter, and the possibility of the spin independent direct detection searches, imposing the constraints of oblique parameters. And we show a benchmark point to satisfy all the constraints and discuss our predictions.

  9. Supergravity corrections to $(g-2)_l$ in differential renormalization

    CERN Document Server

    del Águila, F; Muñoz-Tàpia, R; Pérez-Victoria, M

    1997-01-01

    The method of differential renormalization is extended to the calculati= on of the one-loop graviton and gravitino corrections to $(g-2)_l$ in unbroken supergravity. Rewriting the singular contributions of all the diagrams in= terms of only one singular function, U(1) gauge invariance and supersymmetry ar= e preserved. We compare this calculation with previous ones which made use = of momentum space regularization (renormalization) methods.

  10. T2L2 - Time Transfer by Laser Link

    Science.gov (United States)

    Weick, J.; Samain, E.; Bério, Ph.

    2005-12-01

    T2L2 is an experiment based on laser ranging technique coupled with time-frequency metrology. The goal consists in synchronizing ground and space clocks using short light pulses travelling between the ground and a satellite. The instrument will be integrated to the Jason-2 altimetric satellite launched in 2008. The experiment should enhance the performances of time transfert by one or two magnitudes compared to existing microwave techniques like GPS and Two-Way.

  11. Commercial Aircraft Noise Definition - L-1011 Tristar. Volume 2-L-1011-1 Data

    Science.gov (United States)

    1974-09-01

    o0 % nco E~- t-- E-4 00 E-.4 \\Io \\ L \\ n $ 0 \\ co 0 434 @10 A ~ ~ C V* C6 ~0 QOýQ2 -.- 4 2-36 5- 𔃾aCo t-~ ~~~-C 0- *D * * ** * H ~ ~ ~ ~ -b-H 0...POW. O𔃽 0𔃾Q ’U. W5-2 "Fu C6 0 O 0 0-4 -W -NNN0 44 N N N N cN 0- M-DP’J . IA -c ~ L .- ~ .. s~ w . Nl w4 m oO fL af NC Pý - 4 P-~ P. .0~ Ij~ I.. IA...0 4QP,,0 0 M.. CN ’M " -" f " AA on , .. S. - C*. *e.* N P- a, aQ s 06 4 0 01 V% A Nt N @- Nif N P4 N ft p. !iMi o, -A-.0 I.’ • m l-00,,,..0 • 1

  12. Status of soluble ST2 levels in serum of HTLV-1 infected individuals.

    Science.gov (United States)

    Zahedi Avval, Farnaz; Shomali, Shadi; Nadri, Mohammad; Boostani, Reza; Jarahi, Lida; Youssefi, Masoud

    2015-06-01

    ST2 is a member of IL-1 receptor family expressed on Th2 cells and regulates Th2 responces. The gene of ST2 encodes soluble ST2 (sST2) and the transmembrane ST2 (ST2L) isoforms through alternative mRNA splicing. The discovery of IL33/ ST2 signaling pathway, has drawn a great scientific attention to this system. sST2 has been shown to be an indacating factor in various infl ammatory conditions. This study aims to evaluate serum sST2 levels in HTLV-1 infected patients. This study included 49 HTLV-1 seropositive cases of which 14 were sympthomatic. Controls consisted of 30 healthy volunteers. sST2 level was measured using a quantitative ELISA assay and the results of the study groups were compared. Corroborating the previous reports, sST2 was lower in females (P = 0.003). The sST2 levels was slightly increased in HTLV-1 patients, though such increase was not statistically significant (P = 0.91), in addition sST2 level did not correlate significantly to the disease duration (P = 0.78). Despite some other chronic viral infection, HTLV-1 seems not to induce high serum sST2. However owing to relatively high normal variation of sST2 levels and rather small sample size, we stongly recommend further reseach with preferably larger sample size to evalute sST2 in HTLV-1 infected patients.

  13. Hydrogen Learning for Local Leaders – H2L3

    Energy Technology Data Exchange (ETDEWEB)

    Serfass, Patrick

    2017-03-30

    The Hydrogen Learning for Local Leaders program, H2L3, elevates the knowledge about hydrogen by local government officials across the United States. The program reaches local leaders directly through “Hydrogen 101” workshops and webinar sessions; the creation and dissemination of a unique report on the hydrogen and fuel cell market in the US, covering 57 different sectors; and support of the Hydrogen Student Design Contest, a competition for interdisciplinary teams of university students to design hydrogen and fuel cell systems based on technology that’s currently commercially available.

  14. St. John's Wort (image)

    Science.gov (United States)

    The herb St. John's Wort is believed to be helpful in relieving mild to moderate depression, but should only be taken under a physician's supervision. St. John's Wort may clash with other medications or foods a ...

  15. Roegneria alashanica Keng: a species with the StStSt(Y)St(Y) genome constitution.

    Science.gov (United States)

    Wang, Richard R-C; Jensen, Kevin B

    2017-06-01

    The genome constitution of tetraploid Roegneria alashanica Keng has been in question for a long time. Most scientific studies have suggested that R. alashanica had two versions of the St genome, St1St2, similar to that of Pseudoroegneria elytrigioides (C. Yen & J.L. Yang) B.R. Lu. A study, however, concluded that R. alashanica had the StY genome formula typical for tetraploid species of Roegneria. For the present study, R. alashanica, Elymus longearistatus (Bioss.) Tzvelev (StY genomes), Pseudoroegneria strigosa (M. Bieb.) Á. Löve (St), Pseudoroegneria libanoctica (Hackel) D.R. Dewey (St), and Pseudoroegneria spicata (Pursh) Á. Löve (St) were screened for the Y-genome specific marker B14(F+R)269. All E. longearistatus plants expressed intense bands specific to the Y genome. Only 6 of 10 R. alashanica plants exhibited relatively faint bands for the STS marker. Previously, the genome in species of Pseudoroegneria exhibiting such faint Y-genome specific marker was designated as St(Y). Based on these results, R. alashanica lacks the Y genome in E. longearistatus but likely possess two remotely related St genomes, St and St(Y). According to its genome constitution, R. alashanica should be classified in the genus Pseudoroenera and given the new name Pseudoroegneria alashanica (Keng) R.R.-C. Wang and K.B. Jensen.

  16. 21st International Meshing Roundtable

    CERN Document Server

    Weill, Jean-Christophe

    2013-01-01

    This volume contains the articles presented at the 21st International Meshing Roundtable (IMR) organized, in part, by Sandia National Laboratories and was held on October 7–10, 2012 in San Jose, CA, USA. The first IMR was held in 1992, and the conference series has been held annually since. Each year the IMR brings together researchers, developers, and application experts in a variety of disciplines, from all over the world, to present and discuss ideas on mesh generation and related topics. The technical papers in this volume present theoretical and novel ideas and algorithms with practical potential, as well as technical applications in science and engineering, geometric modeling, computer graphics, and visualization.

  17. Summary of Synoptic Meteorological Observations (SSMO). South America and Selected Island Coastal Marine Areas, Atlantic Islands. Volume 3. Area 17 - Tierra del Fuego, Area 18 - Falkland Islands, Area 19 -South Georgia, Area 20 - Tristan da Cunha Group, Area 21 - Trindade, Area 22 - St. Helena, Area 23 - Ascension, Area 24 - St. Peter and Paul Rocks

    Science.gov (United States)

    1977-06-01

    0 17.5 .0 .0 .0 .0 .0 .0 .0 FACE »21 »TW* ■■’■ "■ IIUI" »E«ICD! fOVE«-«LO 1963-1970 JANUARY TABLE 18 (CONTi IKEA 0021 TOINDADE...DIRECTION VIPSuS SE4 HEIGHTS IFTl IKEA 0024 ST, PETER AND PAUL ROCKS ,6N 29.3» s iu HGT 1-3 4-10 11-21 22-33 34-47 41« PCT 1...l". - L ■■■’■■’ • ’ " wwm PEIKOl iQVER-»LLI IS’OS-l1»?» I SFPTEMBfR TABLE 16 (CDNT1 IKEA 002« ST. PETER AND PAUL RCfKS

  18. Surveys in 1961 on St. Thomas & St. Croix

    DEFF Research Database (Denmark)

    Dahl, Thorkel; Licht, Kjeld de Fine

    2004-01-01

    Registration of towns and buildings erected during the Danish reign of the Caribbean Isles of St. Thomas, St. Jan and St. Croix 1671-1917 (now belonging to the USA under the name of Virgin Islands).......Registration of towns and buildings erected during the Danish reign of the Caribbean Isles of St. Thomas, St. Jan and St. Croix 1671-1917 (now belonging to the USA under the name of Virgin Islands)....

  19. Latest Results from the PICO-2L Dark Matter Detector, and the identification and mitigation of particulate-induced backgrounds

    Science.gov (United States)

    Baxter, Daniel; PICO Collaboration

    2016-03-01

    The PICO Collaboration has taken a key step toward a background-free bubble chamber for WIMP dark matter detection. An unexpected background of unknown origin limited WIMP searches in the PICO-2L and PICO-60 detectors at SNOLAB in 2013 and 2014. Recent efforts targeting particulate contamination in the active volume of PICO-2L have reduced this background by at least one order of magnitude, to a rate below the known neutron background in the detector. The resulting data set the most stringent limit to date from a direct detection experiment on spin-dependent WIMP-proton interactions. I will present a comparison of the background-limited Run-1 of PICO-2L with the new results from Run-2, identifying particulate as the primary source of the previously unexplained background. I will describe the engineering and operational controls now being implemented to eliminate this background in the PICO-60 detector, with the goal of a background-free run using our large detector within the next year. Supported in part by Department of Energy award #DE-SC0012161.

  20. Distortion of He(2l2l`) Fano lineshapes by strong post-collision interaction in H{sup +}-He collisions

    Energy Technology Data Exchange (ETDEWEB)

    Moretto-Capelle, P.; Benhenni, M.; Bordenave-Montesquieu, D.; Bordenave-Montesquieu, A. [Toulouse-3 Univ., 31 (France)

    1996-05-28

    The three-body post-collisional interaction (PCI) between the scattered proton, recoil target ion and emitted electron has been investigated by electron spectrometry near the 2l2l` helium resonances, in the 20-100 keV energy range (V{sub p} 0.9-2 au). Particular attention has been paid to the PCI deformations of the Fano lineshapes when V-vector``{sub p} {approx_equal} V-vector {sub e}(2l2l`). Their angle and collision velocity dependences have been studied for the first time experimentally. A large variety of lineshapes have been observed, all of them successfully described by a single formula. At the lowest proton velocities the rescattering effect (also called Coulomb two-path scattering) is seen. (Author).

  1. 31st IMAC Conference on Structural Dynamics

    CERN Document Server

    Adams, Douglas; Carrella, Alex; Mayes, Randy; Rixen, Daniel; Allen, Matt; Cunha, Alvaro; Catbas, Fikret; Pakzad, Shamim; Racic, Vitomir; Pavic, Aleksandar; Reynolds, Paul; Simmermacher, Todd; Cogan, Scott; Moaveni, Babak; Papadimitriou, Costas; Allemang, Randall; Clerck, James; Niezrecki, Christopher; Wicks, Alfred

    2013-01-01

    Topics in Nonlinear Dynamics, Volume 1: Proceedings of the 31st IMAC, A Conference and Exposition on Structural Dynamics, 2013, the first volume of seven from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on fundamental and applied aspects of Structural Dynamics, including papers on:   Nonlinear Oscillations Nonlinearities In Practice Nonlinear System Identification: Methods Nonlinear System Identification: Friction & Contact Nonlinear Modal Analysis Nonlinear Modeling & Simulation Nonlinear Vibration Absorbers Constructive Utilization of Nonlinearity.

  2. St. Croix trap study

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The data set contains detailed information about the catch from 600 trap stations around St. Croix. Data fields include species caught, size data, trap location...

  3. Distribution of Functional Liver Volume in Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombus in the 1st Branch and Main Trunk Using Single Photon Emission Computed Tomography—Application to Radiation Therapy

    Directory of Open Access Journals (Sweden)

    Akira Ikoma

    2011-10-01

    Full Text Available Purpose: To analyze the distribution of functional liver volume (FLV in the margin volume (MV surrounding hepatocellular carcinoma (HCC with portal vein tumor thrombus (PVTT before radiation therapy (RT and to verify the safety of single photon emission computed tomography-based three-dimensional conformal radiotherapy (SPECT-B3DCRT by exploring the relation of FLV in MV to radiation-induced liver disease (RILD. Methods and Materials: Clinical target volume (CTV included main tumor and PVTT, and planning target volume (PTV included CTV with a 10 mm margin. MV was defined as PTV–CTV. FLV ratio in MV was calculated as FLV in MV/MV × 100 (%. The two high-dose beams were planned to irradiate FLV as little as possible. Fifty-seven cases of HCC (26/57, 46%; Child–Pugh grade B with PVTT underwent SPECT-B3DCRT which targeted the CTV to a total dose of 45 Gy/18 fractions. The destructive ratio was defined as radiation induced dysfunctional volume/FLV × 100 (%. Results: We observed a significant negative correlation between FLV ratio in MV and CTV (p < 0.001. Three cases with CTVs of 287, 587 and 1184 cm3 experienced transient RILD. The FLV ratio in MV was highest in patients with RILD: nine patients with CTV of 200–300 cm3, three with CTV of 500–600 cm3, and two with CTV of 1100–1200 cm3. The destructive ratio yielded a mean value of 24.2 ± 1.5%. Conclusions: Radiation planning that takes into account the distribution of FLV appears to result in the least possible RILD.

  4. Enzymic and chemical synthesis of epilson-N-(L-propionyl-2)-L-lysine.

    Science.gov (United States)

    Fujioka, M; Tanaka, M

    1978-10-01

    Pyruvate was shown to act as an oxo acid substrate in the reverse direction of saccharopine dehydrogenase [epsilon N-(L-glutaryl-2)-L-lysine: NAD oxidoreductase (L-lysine-forming)] reaction. The enzymic condensation product of lysine and pyruvate was isolated and identified as epsilon-N-(L-propionyl-2)-L-lysine by comparison with the synthetic compound. A method for the chemical preparation of diastereoisomers of epsilon-N-(propionyl-2)-L-lysine is also described.

  5. Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

    Science.gov (United States)

    Pajares, Marta; Jiménez-Moreno, Natalia; García-Yagüe, Ángel J.; Escoll, Maribel; de Ceballos, María L.; Van Leuven, Fred; Rábano, Alberto; Yamamoto, Masayuki; Rojo, Ana I.; Cuadrado, Antonio

    2016-01-01

    ABSTRACT Autophagy is a highly coordinated process that is controlled at several levels including transcriptional regulation. Here, we identify the transcription factor NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2) as a regulator of autophagy gene expression and its relevance in a mouse model of Alzheimer disease (AD) that reproduces impaired APP (amyloid β precursor protein) and human (Hs)MAPT/TAU processing, clearance and aggregation. We screened the chromatin immunoprecipitation database ENCODE for 2 proteins, MAFK and BACH1, that bind the NFE2L2-regulated enhancer antioxidant response element (ARE). Using a script generated from the JASPAR's consensus ARE sequence, we identified 27 putative AREs in 16 autophagy-related genes. Twelve of these sequences were validated as NFE2L2 regulated AREs in 9 autophagy genes by additional ChIP assays and quantitative RT-PCR on human and mouse cells after NFE2L2 activation with sulforaphane. Mouse embryo fibroblasts of nfe2l2-knockout mice exhibited reduced expression of autophagy genes, which was rescued by an NFE2L2 expressing lentivirus, and impaired autophagy flux when exposed to hydrogen peroxide. NFE2L2-deficient mice co-expressing HsAPPV717I and HsMAPTP301L, exhibited more intracellular aggregates of these proteins and reduced neuronal levels of SQSTM1/p62, CALCOCO2/NDP52, ULK1, ATG5 and GABARAPL1. Also, colocalization of HsAPPV717I and HsMAPTP301L with the NFE2L2-regulated autophagy marker SQSTM1/p62 was reduced in the absence of NFE2L2. In AD patients, neurons expressing high levels of APP or MAPT also expressed SQSTM1/p62 and nuclear NFE2L2, suggesting their attempt to degrade intraneuronal aggregates through autophagy. This study shows that NFE2L2 modulates autophagy gene expression and suggests a new strategy to combat proteinopathies. PMID:27427974

  6. Phonological Substitution Errors in L2 ASL Sentence Processing by Hearing M2L2 Learners

    Science.gov (United States)

    Williams, Joshua; Newman, Sharlene

    2016-01-01

    In the present study we aimed to investigate phonological substitution errors made by hearing second language (M2L2) learners of American Sign Language (ASL) during a sentence translation task. Learners saw sentences in ASL that were signed by either a native signer or a M2L2 learner. Learners were to simply translate the sentence from ASL to…

  7. NFE2L2 polymorphisms, mortality, and metabolism in the general population

    NARCIS (Netherlands)

    Figarska, Sylwia M.; Vonk, Judith M.; Boezen, Hendrika

    2014-01-01

    The nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or NRF2) gene regulates transcription of enzymes involved in cellular detoxification and lipids homeostasis. NFE2L2 is associated with pathophysiology of atherosclerosis and chronic obstructive pulmonary disease (COPD). Therefore we studied the

  8. MemType-2L: a web server for predicting membrane proteins and their types by incorporating evolution information through Pse-PSSM.

    Science.gov (United States)

    Chou, Kuo-Chen; Shen, Hong-Bin

    2007-08-24

    Given an uncharacterized protein sequence, how can we identify whether it is a membrane protein or not? If it is, which membrane protein type it belongs to? These questions are important because they are closely relevant to the biological function of the query protein and to its interaction process with other molecules in a biological system. Particularly, with the avalanche of protein sequences generated in the Post-Genomic Age and the relatively much slower progress in using biochemical experiments to determine their functions, it is highly desired to develop an automated method that can be used to help address these questions. In this study, a 2-layer predictor, called MemType-2L, has been developed: the 1st layer prediction engine is to identify a query protein as membrane or non-membrane; if it is a membrane protein, the process will be automatically continued with the 2nd-layer prediction engine to further identify its type among the following eight categories: (1) type I, (2) type II, (3) type III, (4) type IV, (5) multipass, (6) lipid-chain-anchored, (7) GPI-anchored, and (8) peripheral. MemType-2L is featured by incorporating the evolution information through representing the protein samples with the Pse-PSSM (Pseudo Position-Specific Score Matrix) vectors, and by containing an ensemble classifier formed by fusing many powerful individual OET-KNN (Optimized Evidence-Theoretic K-Nearest Neighbor) classifiers. The success rates obtained by MemType-2L on a new-constructed stringent dataset by both the jackknife test and the independent dataset test are quite high, indicating that MemType-2L may become a very useful high throughput tool. As a Web server, MemType-2L is freely accessible to the public at http://chou.med.harvard.edu/bioinf/MemType.

  9. St. Vincent Island Tour

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This letter, written by Charles Marks who lived on St. Vincent Island as a child, notes the changes he saw in the island when he visited in 1981. He notes that the...

  10. Small-Volume Injections: Evaluation of Volume Administration Deviation From Intended Injection Volumes.

    Science.gov (United States)

    Muffly, Matthew K; Chen, Michael I; Claure, Rebecca E; Drover, David R; Efron, Bradley; Fitch, William L; Hammer, Gregory B

    2017-10-01

    In the perioperative period, anesthesiologists and postanesthesia care unit (PACU) nurses routinely prepare and administer small-volume IV injections, yet the accuracy of delivered medication volumes in this setting has not been described. In this ex vivo study, we sought to characterize the degree to which small-volume injections (≤0.5 mL) deviated from the intended injection volumes among a group of pediatric anesthesiologists and pediatric postanesthesia care unit (PACU) nurses. We hypothesized that as the intended injection volumes decreased, the deviation from those intended injection volumes would increase. Ten attending pediatric anesthesiologists and 10 pediatric PACU nurses each performed a series of 10 injections into a simulated patient IV setup. Practitioners used separate 1-mL tuberculin syringes with removable 18-gauge needles (Becton-Dickinson & Company, Franklin Lakes, NJ) to aspirate 5 different volumes (0.025, 0.05, 0.1, 0.25, and 0.5 mL) of 0.25 mM Lucifer Yellow (LY) fluorescent dye constituted in saline (Sigma Aldrich, St. Louis, MO) from a rubber-stoppered vial. Each participant then injected the specified volume of LY fluorescent dye via a 3-way stopcock into IV tubing with free-flowing 0.9% sodium chloride (10 mL/min). The injected volume of LY fluorescent dye and 0.9% sodium chloride then drained into a collection vial for laboratory analysis. Microplate fluorescence wavelength detection (Infinite M1000; Tecan, Mannedorf, Switzerland) was used to measure the fluorescence of the collected fluid. Administered injection volumes were calculated based on the fluorescence of the collected fluid using a calibration curve of known LY volumes and associated fluorescence.To determine whether deviation of the administered volumes from the intended injection volumes increased at lower injection volumes, we compared the proportional injection volume error (loge [administered volume/intended volume]) for each of the 5 injection volumes using a linear

  11. Analysis of Expedient Field Decontamination Methods for the XMX/2L-MIL High-Volume Aerosol Sampler

    Science.gov (United States)

    2009-12-01

    niger ) spores were provided by the Life Sciences Division, West Desert Test Center, Dugway Proving Grounds, Utah. B. atrophaeus is commonly used...vials containing sterile water for culture / serial dilutions. During the E. herbicola exposures, Phosphate Buffered Saline (PBS) was used as an

  12. Characterization of St and Y genome in StStYY Elymus species (Triticeae: Poaceae) using Sequential FISH and GISH

    Science.gov (United States)

    Tetraploid species possessing StY genome could be donors to hexaploid species having StYH, StYP, or StYW genome constitution in the genus Elymus, and a few of StY species have been intensely studied for inferring the origin of the Y genome. In this study, genome characterization of St and Y genome w...

  13. Volume Entropy

    CERN Document Server

    Astuti, Valerio; Rovelli, Carlo

    2016-01-01

    Building on a technical result by Brunnemann and Rideout on the spectrum of the Volume operator in Loop Quantum Gravity, we show that the dimension of the space of the quadrivalent states --with finite-volume individual nodes-- describing a region with total volume smaller than $V$, has \\emph{finite} dimension, bounded by $V \\log V$. This allows us to introduce the notion of "volume entropy": the von Neumann entropy associated to the measurement of volume.

  14. The St. Louis Motor

    Science.gov (United States)

    Greenslade, Thomas B.

    2011-10-01

    The St. Louis Motor, invented in 1909, is unique among physics apparatus for being named for a geographical place rather than a physicist. The sturdy little device (Fig. 1) has never been out of production. Any older school or physics department that has not done a catastrophic housecleaning in the last 20 years will certainly have a small flock of them in the back room.

  15. Accuracy validation of T2L2 time transfer in co-location.

    Science.gov (United States)

    Laas-Bourez, Myrtille; Courde, Clément; Samain, Etienne; Exertier, Pierre; Guillemot, Philippe; Torre, Jean-Marie; Martin, Nicolas; Foussard, Claude

    2015-02-01

    The Time Transfer by Laser Link (T2L2) experiment has been developed in close collaboration between Centre National d'Etudes Spatiales and Observatoire de la Côte d'Azur. The aim is to synchronize remote ultra-stable clocks over large-scale distances using two laser ranging stations. This ground to space time transfer has been derived from laser telemetry technology with dedicated space equipment designed to record arrival time of laser pulses on board the satellite. For 3 years, specific campaigns have been organized to prove T2L2 performance. In April 2012, we performed a 2-week campaign with our two laser ranging stations, Métrologie Optique and French Transportable Laser Ranging Station, to demonstrate the T2L2 time transfer accuracy in co-location. We have compared three independent time transfer techniques: T2L2, GPS, and direct measurement, with both an event timer and an interval counter. The most important result obtained in this campaign was a mean agreement between T2L2 and a direct comparison better than 200 ps. This is the first major step to validate the uncertainty budget of the entire T2L2 experiment. This paper focuses on this campaign setup and the obtained results.

  16. School Business Management in the 21st Century.

    Science.gov (United States)

    Association of School Business Officials International, Reston, VA.

    As society's fundamental characteristics change, schools and school leaders must be prepared to modify the educational enterprise to meet the new and unique needs of adults and youngsters in the 21st century. To anticipate and control change, the school business manager must be able to project future trends, issues, and challenges. In this volume,…

  17. PTHrP Overexpression Increases Sensitivity of Breast Cancer Cells to Apo2L/TRAIL.

    Directory of Open Access Journals (Sweden)

    Vanessa Cheung

    Full Text Available Parathyroid hormone-related protein (PTHrP is a key component in breast development and breast tumour biology. PTHrP has been discovered as a causative agent of hypercalcaemia of malignancy and is also one of the main factors implicated in breast cancer mediated osteolysis. Clinical studies have determined that PTHrP expression by primary breast cancers was an independent predictor of improved prognosis. Furthermore, PTHrP has been demonstrated to cause tumour cell death both in vitro and in vivo. Apo2L/TRAIL is a promising new anti-cancer agent, due to its ability to selectively induce apoptosis in cancer cells whilst sparing most normal cells. However, some cancer cells are resistant to Apo2L/TRAIL-induced apoptosis thus limiting its therapeutic efficacy. The effects of PTHrP on cell death signalling pathways initiated by Apo2L/TRAIL were investigated in breast cancer cells. Expression of PTHrP in Apo2L/TRAIL resistant cell line MCF-7 sensitised these cells to Apo2L/TRAIL-induced apoptosis. The actions of PTHrP resulted from intracellular effects, since exogenous treatment of PTHrP had no effect on Apo2L/TRAIL-induced apoptosis. Apo2L/TRAIL-induced apoptosis in PTHrP expressing cells occurred through the activation of caspase-10 resulting in caspase-9 activation and induction of apoptosis through the effector caspases, caspase-6 and -7. PTHrP increased cell surface expression of Apo2L/TRAIL death receptors, TRAIL-R1 and TRAIL-R2. Antagonistic antibodies against the death receptors demonstrated that Apo2L/TRAIL mediated its apoptotic signals through activation of the TRAIL-R2 in PTHrP expressing breast cancer cells. These studies reveal a novel role for PTHrP with Apo2L/TRAIL that maybe important for future diagnosis and treatment of breast cancer.

  18. The respiratory chain supercomplex organization is independent of COX7a2l isoforms.

    Science.gov (United States)

    Mourier, Arnaud; Matic, Stanka; Ruzzenente, Benedetta; Larsson, Nils-Göran; Milenkovic, Dusanka

    2014-12-01

    The organization of individual respiratory chain complexes into supercomplexes or respirasomes has attracted great interest because of the implications for cellular energy conversion. Recently, it was reported that commonly used mouse strains harbor a short COX7a2l (SCAFI) gene isoform that supposedly precludes the formation of complex IV-containing supercomplexes. This claim potentially has serious implications for numerous mouse studies addressing important topics in metabolism, including adaptation to space flights. Using several complementary experimental approaches, we show that mice with the short COX7a2l isoform have normal biogenesis and steady-state levels of complex IV-containing supercomplexes and consequently have normal respiratory chain function. Furthermore, we use a mouse knockout of Lrpprc and show that loss of complex IV compromises respirasome formation. We conclude that the presence of the short COX7a2l isoform in the commonly used C57BL/6 mouse strains does not prevent their use in metabolism research.

  19. Reducing U2R and R2L category false negative rates with support vector machines

    Directory of Open Access Journals (Sweden)

    Maček Nemanja

    2014-01-01

    Full Text Available The KDD Cup '99 is commonly used dataset for training and testing IDS machine learning algorithms. Some of the major downsides of the dataset are the distribution and the proportions of U2R and R2L instances, which represent the most dangerous attack types, as well as the existence of R2L attack instances identical to normal traffic. This enforces minor category detection complexity and causes problems while building a machine learning model capable of detecting these attacks with sufficiently low false negative rate. This paper presents a new support vector machine based intrusion detection system that classifies unknown data instances according both to the feature values and weight factors that represent importance of features towards the classification. Increased detection rate and significantly decreased false negative rate for U2R and R2L categories, that have a very few instances in the training set, have been empirically proven.

  20. T2L2/Jason-2, first year of processing activities

    Science.gov (United States)

    Exertier, P.

    2009-11-01

    The T2L2 (Time Transfer by Laser Link) project, developed by CNES and OCA will permit the synchronization of remote ultra stable clocks and the determination of their performances over intercontinental distances. The principle is derived from laser telemetry technology with a dedicated space equipment designed to record arrival time of laser pulses at the satellite. T2L2 was accepted in 2005 to be on board the Jason-2 altimetry satellite. It has been successfully launched from Vandenberg (CA, US) in June 2008. T2L2 acquired the first laser pulses a few days after the launch. First analysis permitted to validate some important characteristics of the instrument such as sensitivity, noise, dynamic, event timer precision and ground to space time stability.

  1. Communication from ST Group

    CERN Multimedia

    TS Department

    2008-01-01

    In order to prepare the organization of the Open Days, please note that FM Group will not able to take into account either specific requests for waste collection from 2nd to 6th of April, either removal or PC transport requests between the 31st and the 11th of March. We kindly ask you to plan the collection of any type of waste and the urgent transport of office furniture or PC before the 31st of March. Waste collection requests shall be formulated contacting FM Support at 77777 or at the email address mailto:Fm.Support@cern.ch; removal of office furniture or PC transport requests must be made using the EDH ‘Transport request’ form selecting the "Removals" or the "PC transport" category from the drop-down menu. For any question concerning the waste sorting, please consult the following web address: http://dechets-waste.web.cern.ch/dechets-waste/. Thank you for your understanding and collaboration. TS/FM Group

  2. Communication from ST Group

    CERN Multimedia

    TS Department

    2008-01-01

    In order to prepare the organization of the Open Days, please note that FM Group will not able to take into account either specific requests for waste collection from 2nd to 6th of April, either removal or PC transport requests between the 31st and the 11th of March. We kindly ask you to plan the collection of any type of waste and the urgent transport of office furniture or PC before the 31st of March. Waste collection requests shall be formulated contacting FM Support at 77777 or at the email address mailto:Fm.Support@cern.ch; removal of office furniture or PC transport requests must be made using the EDH ‘Transport request’ form selecting the "Removals" or the "PC transport" category from the drop-down menu. For any question concerning the waste sorting, please consult the following web address: http://dechets-waste.web.cern.ch/dechets-waste/. Thank you for your understanding and collaboration. TS/FM Group

  3. St. Thomas Aquinas, Dramatist?

    Directory of Open Access Journals (Sweden)

    Eric McLuhan

    2016-03-01

    Full Text Available The article begins with the statement that there is one aspect of St Thomas’s work that has not received due scrutiny as a literary form, one with solid dramatic qualities and structure: the Article. The Article is as Thomistic as the syllogism is Aristotelian. This particular mode of argument was evidently original with St. Thomas: he did not derive it from the work of any other writer, yet its inner movement is of the essence of dialectic, from the opening proposition to opposing objections, then “to the contrary” position as found in orthodoxy, and then the writer’s resolution, and so on. It is a variation on the classic sic-et-non, a reasonable, balanced to and fro of the sort beloved by disputants. No parallel or even parody of this Article is to be found in any known literature before or since the thirteenth century. The author aims to show that part of the sheer power of the Article resides in the fact that it has two levels of operation. The surface is composed of the dialectical to-and-fro adumbrated above. But under that surface lies a rhetorical structure constructed along the lines of the five divisions of the rhetorical logos as laid out by Cicero and Horace.

  4. ASK-IT/A2L: Assessing student knowlede with instructional technology

    CERN Document Server

    Dufresne, R J; Leonard, W J; Mestre, J P

    2005-01-01

    The ASK-IT/Assessing-to-Learn (A2L) project is an attempt to bring a strategic approach to learning, instruction, and communication. ASK-IT/A2L seeks to integrate formative assessment and classroom response system use with physics instruction at both the high school and college levels. In this guide, we present a structure for discussing the new mindset students need in an ASK-IT/A2L classroom, consisting of twelve "habits of mind" for students to develop. To help teachers plan instruction, we present a model of five stages of cognitive development that most students need to follow to develop desirable knowledge and skills. We show how a typical lesson might be organized around "items," the smallest unit of ASK-IT/A2L lesson planning: questions, problems, or tasks given to students to work on individually or in groups. To help with item creation, we present our model-based design paradigm and suggest tips for avoiding common pitfalls and ways to match up cognitive goals with habits of mind. Finally, we apply ...

  5. A Design of 2L-Channel FIR Paraunitary Filter Banks with Complex Coefficients

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    An algorithm is proposed for the design of 2L-channel FIR paraunitary filter banks with complex coefficients to meet the requirement of processing complex signals. The filter designed with the algorithm has the property of near linear-phase. Thus, there is no more phase distortions introduced to the phase spectrum.

  6. Molecular and genomic studies of IMMP2L and mutation screening in autism and Tourette syndrome.

    Science.gov (United States)

    Petek, Erwin; Schwarzbraun, Thomas; Noor, Abdul; Patel, Megha; Nakabayashi, Kazuhiko; Choufani, Sanaa; Windpassinger, Christian; Stamenkovic, Mara; Robertson, Mary M; Aschauer, Harald N; Gurling, Hugh M D; Kroisel, Peter M; Wagner, Klaus; Scherer, Stephen W; Vincent, John B

    2007-01-01

    We recently reported the disruption of the inner mitochondrial membrane peptidase 2-like (IMMP2L) gene by a chromosomal breakpoint in a patient with Gilles de la Tourette syndrome (GTS). In the present study we sought to identify genetic variation in IMMP2L, which, through alteration of protein function or level of expression might contribute to the manifestation of GTS. We screened 39 GTS patients, and, due to the localization of IMMP2L in the critical region for the autistic disorder (AD) locus on chromosome 7q (AUTS1), 95 multiplex AD families; however, no coding mutations were found in either GTS or AD patients. In addition, no parental-specific expression of IMMP2L was detected in somatic cell hybrids containing human chromosome 7 and human cell lines carrying a maternal uniparental disomy for chromosome 7 (mUPD7). Despite the fact that no deleterious mutations in IMMPL2 (other than the inverted duplication identified previously) were identified in either GTS or AD, this gene cannot be excluded as a possible rare cause of either disorder.

  7. Time transfer by laser link (T2L2): characterization and calibration of the flight instrument

    Science.gov (United States)

    Samain, E.; Vrancken, P.; Guillemot, P.; Fridelance, P.; Exertier, P.

    2014-10-01

    The T2L2 project (time transfer by laser link) allows for the synchronization of remote ultra-stable clocks over intercontinental distances (Fridelance et al 1997 Exp. Astron. 7, Samain and Fridelance 1998 Metrologia 35 151-9). The principle is derived from satellite laser ranging technology with dedicated space equipment designed to record arrival times of laser pulses at the satellite. The space segment has been launched in June 2008 as a passenger experiment on the ocean altimetry satellite Jason 2. T2L2 had been specified to yield a time stability of better than 1 ps over 1000 s integration time and an accuracy of better than 100 ps. This level of performance requires a rigorous data processing which can be performed only with a comprehensive calibration model of the whole instrumentation. For this purpose, several experimental measurements have been performed before and during the integration phase of the T2L2 space instrument. This instrument model is one of the cornerstones of the data reduction process which is carried out to translate the raw information to a usable picosecond time transfer. After providing a global synopsis of the T2L2 space instrument, the paper gives a description of the experimental setup for the instrument characterization. It then details the different contributions within the calibration model and concludes with an applied example of a space to ground time transfer.

  8. Zebrafish bcl2l is a survival factor in thyroid development.

    Science.gov (United States)

    Porreca, Immacolata; De Felice, Elena; Fagman, Henrik; Di Lauro, Roberto; Sordino, Paolo

    2012-06-15

    Regulated cell death, defined in morphological terms as apoptosis, is crucial for organ morphogenesis. While differentiation of the thyroid gland has been extensively studied, nothing is yet known about the survival mechanisms involved in the development of this endocrine gland. Using the zebrafish model system, we aim to understand whether genes belonging to the Bcl-2 family that control apoptosis are implicated in regulation of cell survival during thyroid development. Evidence of strong Bcl-2 gene expression in mouse thyroid precursors prompted us to investigate the functions played by its zebrafish homologs during thyroid development. We show that the bcl2-like (bcl2l) gene is expressed in the zebrafish thyroid primordium. Morpholino-mediated knockdown and mutant analyses revealed that bcl2l is crucial for thyroid cell survival and that this function is tightly modulated by the transcription factors pax2a, nk2.1a and hhex. Also, the bcl2l gene appears to control a caspase-3-dependent apoptotic mechanism during thyroid development. Thyroid precursor cells require an actively maintained survival mechanism to properly proceed through development. The bcl2l gene operates in the inhibition of cell death under direct regulation of a thyroid specific set of transcription factors. This is the first demonstration of an active mechanism to ensure survival of the thyroid primordium during morphogenesis.

  9. Technology Directions for the 21st Century. Volume 3

    Science.gov (United States)

    Crimi, Giles F.; Botta, Robert; Ditanna, Thomas; Verheggen, Henry; Stancati, Michael; Feingold, Harvey; Jacobs, Mark

    1996-01-01

    New technologies will unleash the huge capacity of fiber-optic cable to meet growing demands for bandwidth. Companies will continue to replace private networks with public network bandwidth-on-demand. Although asynchronous transfer mode (ATM) is the transmission technology favored by many, its penetration will be slower than anticipated. Hybrid networks - e.g., a mix of ATM, frame relay, and fast Ethernet - may predominate, both as interim and long-term solutions, based on factors such as availability, interoperability, and cost. Telecommunications equipment and services prices will decrease further due to increased supply and more competition. Explosive Internet growth will continue, requiring additional backbone transmission capacity and enhanced protocols, but it is not clear who will fund the upgrade. Within ten years, space-based constellations of satellites in Low Earth orbit (LEO) will serve mobile users employing small, low-power terminals. 'Little LEO's' will provide packet transmission services and geo-position determination. 'Big LEO's' will function as global cellular telephone networks, with some planning to offer video and interactive multimedia services. Geosynchronous satellites also are proposed for mobile voice grade links and high-bandwidth services. NASA may benefit from resulting cost reductions in components, space hardware, launch services, and telecommunications services.

  10. Atlas international de la vitalite linguistique. Volume 2: L'Europe Occidentale = International Atlas of Language Vitality. Volume 2: Western Europe.

    Science.gov (United States)

    McConnell, Grant D., Ed.; Gendron, Jean-Denis, Ed.

    The atlas offers a cartography of language functions, quantitatively measured in vitality rates, for Western Europe. The atlas has three parts: vitality by language; vitality by domain; and vitality by country. Eighty-three minority languages are covered. Domains considered include: global; religion; schools; mass media; administration; courts;…

  11. Expression patterns of LmAP2L1 and LmAP2L2 encoding two-APETALA2 domain proteins during somatic embryogenesis and germination of hybrid larch (Larix x marschlinsii).

    Science.gov (United States)

    Guillaumot, Damien; Lelu-Walter, Marie-Anne; Germot, Agnès; Meytraud, Fanny; Gastinel, Louis; Riou-Khamlichi, Catherine

    2008-06-16

    Two APETALA2 domain transcription factors were characterized first in angiosperms, and, recently, in several gymnosperms. These proteins are involved in several processes, from flowering to embryogenesis in Arabidopsis thaliana. We extrapolated this result to hybrid larch (Larixxmarschlinsii Coaz) resulting from a cross between European (Larix decidua) and Japanese (Larix kaempferi) larches. Somatic embryogenesis is well described and controlled for this Pinaceae. We characterized two-AP2 domain genes: LmAP2L1 and LmAP2L2. Phylogenetic analysis confirmed that LmAP2L1 and LmAP2L2 were orthologous to Norway spruce PaAP2L1 and PaAP2L2 and that L1 forms appeared to be specific to Pinaceae. RT-PCR analysis showed that larch APETALA2 was differentially expressed during late somatic embryogenesis and during the first steps of germination. Whereas LmAP2L2 was constitutively expressed during this process, LmAP2L1 expression appeared only during late somatic embryogenesis, when embryos were able to germinate. Further, LmAP2L1 appeared to be the preferentially expressed form during embryo germination. Thus, LmAP2L1 seems to be a valuable molecular marker for hybrid larch late somatic embryogenesis and could play a role during post-embryonic development.

  12. A balanced translocation disrupting BCL2L10 and PNLDC1 segregates with affective psychosis

    Science.gov (United States)

    Bouwkamp, Christian G.; Kievit, Anneke J. A.; Olgiati, Simone; Breedveld, Guido J.; Coesmans, Michiel; Bonifati, Vincenzo

    2016-01-01

    Affective psychoses are a group of severe psychiatric disorders, including schizoaffective disorder and bipolar I disorder, together affecting ∼1% of the population. Despite their high heritability, the molecular genetics and neurobiology of affective psychosis remain largely elusive. Here, we describe the identification of a structural genetic variant segregating with affective psychosis in a family with multiple members suffering from bipolar I disorder or schizoaffective disorder, bipolar type. A balanced translocation involving chromosomes 6 and 15 was detected by karyotyping and fluorescence in‐situ hybridization (FISH). Using whole‐genome sequencing, we rapidly delineated the translocation breakpoints as corresponding intragenic events disrupting BCL2L10 and PNLDC1. These data warrant further consideration for BCL2L10 and PNLDC1 as novel candidates for affective psychosis. © 2016 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc. PMID:27260655

  13. Seafloor elevation change in Maui, St. Croix, St. Thomas, and the Florida Keys

    Science.gov (United States)

    Yates, Kimberly K.; Zawada, David G.; Smiley, Nathan A.; Range, Ginger; Resnick, Jessica

    2017-01-01

    The U.S. Geological Survey (USGS) St. Petersburg Coastal and Marine Science Center conducted research to quantify the combined effect of all constructive and destructive processes on modern coral reef ecosystems by measuring regional-scale changes in seafloor elevation. USGS staff assessed five coral reef ecosystems in the Atlantic Ocean (Upper and Lower Florida Keys), Caribbean Sea (U.S. Virgin Islands: St. Thomas and Buck Island, St. Croix), and Pacific Ocean (Maui, Hawaii), including both coral-dominated and adjacent, non-coral dominated habitats. Scientists used historical bathymetric data from the 1930s to 1980s and contemporary light detection and ranging (lidar) digital elevation models (DEMs) from the late 1990s to 2000s to calculate changes in seafloor elevation for each study site over time periods reflecting low to high anthropogenic impacts. This data release contains the location, elevation, and elevation change data used in this study. Using these changes in elevation, further analysis was done to calculate corresponding changes in seafloor volume for all study areas and habitat types within each site.For further information regarding data analysis methods refer to DOI: 10.5194/bg-14-1739-2017

  14. Active Dirac Neutrinos via $SU(2)_L$ Doublets in 5d

    CERN Document Server

    Fujimoto, Yukihiro; Nagasawa, Tomoaki; Nishiwaki, Kenji; Sakamoto, Makoto; Tatsumi, Kentaro

    2016-01-01

    We propose a new mechanism to generate minuscule active neutrino masses in a five-dimensional (5d) spacetime of an interval without introducing $SU(2)_L$ singlet neutrinos. Under asymmetric boundary conditions on the two end points, a bulk mass for a 5d fermion allows a Dirac particle with a tiny mass eigenvalue. Implementing this mechanism to the standard model gauge structure is possible when all the gauge bosons and the Higgs boson are localized on one of the branes.

  15. Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease

    Directory of Open Access Journals (Sweden)

    Nilsson Michael

    2010-03-01

    Full Text Available Abstract Background Oxidative stress is heavily implicated in the pathogenic process of Parkinson's disease. Varying capacity to detoxify radical oxygen species through induction of phase II antioxidant enzymes in substantia nigra may influence disease risk. Here, we hypothesize that variation in NFE2L2 and KEAP1, the genes encoding the two major regulators of the phase II response, may affect the risk of Parkinson's disease. Methods The study included a Swedish discovery case-control material (165 cases and 190 controls and a Polish replication case-control material (192 cases and 192 controls. Eight tag single nucleotide polymorphisms representing the variation in NFE2L2 and three representing the variation in KEAP1 were chosen using HapMap data and were genotyped using TaqMan Allelic Discrimination. Results We identified a protective NFE2L2 haplotype in both of our European case-control materials. Each haplotype allele was associated with five years later age at onset of the disease (p = 0.001 in the Swedish material, and decreased risk of PD (p = 2 × 10-6, with an odds ratio of 0.4 (95% CI 0.3-0.6 for heterozygous and 0.2 (95% CI 0.1-0.4 for homozygous carriers, in the Polish material. The identified haplotype includes a functional promoter haplotype previously associated with high transcriptional activity. Genetic variation in KEAP1 did not show any associations. Conclusion These data suggest that variation in NFE2L2 modifies the Parkinson's disease process and provide another link between oxidative stress and neurodegeneration.

  16. Time Transfer by Laser Link - T2L2: Results of the First Year of Operation

    Science.gov (United States)

    2009-11-01

    have demonstrated noise levels of some tens of picoseconds and a preliminary time stability of a few picoseconds over integration times of some tens ...satellite clocks (the ultra-stable oscillator USO of DORIS in the case of Jason-2) to be synchronized are linked to a laser station and to the T2L2...possible to compute a synthetic time of flight obtained over an integration duration of few tens of seconds. This method is pertinent in two cases

  17. Dark Matter Limits From a 2L C3F8 Filled Bubble Chamber

    Energy Technology Data Exchange (ETDEWEB)

    Robinson, Alan Edward [Univ. of Chicago, IL (United States)

    2015-12-01

    The PICO-2L C3F8 bubble chamber search forWeakly Interacting Massive Particle (WIMP) dark matter was operated in the SNOLAB underground laboratory at the same location as the previous CF3I lled COUPP-4kg detector. Neutron calibrations using photoneutron sources in C3F8 and CF3I lled calibration bubble chambers were performed to verify the sensitivity of these target uids to dark matter scattering. This data was combined with similar measurements using a low-energy neutron beam at the University of Montreal and in situ calibrations of the PICO-2L and COUPP-4kg detectors. C3F8 provides much greater sensitivity to WIMP-proton scattering than CF3I in bubble chamber detectors. PICO-2L searched for dark matter recoils with energy thresholds below 10 keV. Radiopurity assays of detector materials were performed and the expected neutron recoil background was evaluated to be 1.6+0:3

  18. Libraries in the early 21st century, v.2 an international perspective

    CERN Document Server

    2012-01-01

    Following the pattern of the first volume, the second volume of Libraries in the early 21st century: An international perspective extends the range of countries covered. Each chapter covers a different country and describes the modern history, development of libraries and library technology. The careful selection of countries achieves good representation of professional library work on all continents.This two-volume work represents an excellent contribution to international librarianship and allows comparative studies both at graduate and professional level.

  19. St. Vincent Handwritten History Notes

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document gives historical highlights of St. Vincent Island from the Creek and Seminole Native Americans who inhabited the island in the 1700's to the Loomis...

  20. St. John's Wort and Depression

    Science.gov (United States)

    ... W X Y Z St. John's Wort and Depression: In Depth Share: On This Page Introduction Key ... will help ensure coordinated and safe care. About Depression Depression is a medical condition that affects about ...

  1. St. Vincent History Research Correspondence

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document contains a series of letters about the locations of the Confederate fortress that existed on St. Vincent Island during the Civil War.

  2. The St. Petersburg paradox: An experimental solution

    Science.gov (United States)

    Da Silva, Sergio; Matsushita, Raul

    2016-03-01

    The St. Petersburg paradox refers to a gamble of infinite expected value, where people are likely to spend only a small entrance fee for it. There is a huge volume of literature that mostly concentrates on the psychophysics of the game; experiments are scant. Here, rather than focusing on the psychophysics, we offer an experimental, "physical" solution as if robots played the game. After examining the time series formed by one billion plays, we: confirm that there is no characteristic scale for this game; explicitly formulate the implied power law; and identify the type of α-stable distribution associated with the game. We find an α = 1 and, thus, the underlying distribution of the game is a Cauchy flight, as hinted by Paul Samuelson.

  3. Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain

    Energy Technology Data Exchange (ETDEWEB)

    Sarvan, Sabina; Avdic, Vanja; Tremblay, Véronique; Chaturvedi, Chandra-Prakash; Zhang, Pamela; Lanouette, Sylvain; Blais, Alexandre; Brunzelle, Joseph S; Brand, Marjorie; Couture, Jean-François (Ottawa Hosp.); (Ottawa); (NWU)

    2012-05-02

    Absent, small or homeotic discs-like 2 (ASH2L) is a trithorax group (TrxG) protein and a regulatory subunit of the SET1 family of lysine methyltransferases. Here we report that ASH2L binds DNA using a forkhead-like helix-wing-helix (HWH) domain. In vivo, the ASH2L HWH domain is required for binding to the {beta}-globin locus control region, histone H3 Lys4 (H3K4) trimethylation and maximal expression of the {beta}-globin gene (Hbb-1), validating the functional importance of the ASH2L DNA binding domain.

  4. Herrens röst

    DEFF Research Database (Denmark)

    Rösing, Lilian Munk

    2015-01-01

    Om språket är gränsen mellan djur och människor, vad innebär det när hundar talar? I filmen Upp pratar de animerade hundarna, men med sin husses röst. Lilian Munk Rösing ser filmen i sällskap av bland andra Jacques Lacan, Slavoj Žižek och Renata Salecl och finner en röst utan kropp, en kropp...

  5. The Initial Giant Umbrella Cloud of the May 18, 1980 Explosive Eruption of Mount St. Helens.

    Science.gov (United States)

    1986-09-30

    work allows estimates to be made of the volumes of material in the cloud and the initial temperature of the pyroclastic mixture. The surge and flow...the major pyroclastic surge of May 18, 1980 at Mount St. Helens, Washington. Master’s Thesis, University of California at Santa Barbara, 145 pp...SUPPLEMENTARY NOTES 19. KEY WORDS (Continue on reverse aide If necessary nd Identify by block anber) Mount St. Helens Pyroclastic flow Volcanic clouds

  6. A novel transgenic mouse model of Chinese Charcot-Marie-Tooth disease type 2L

    Institute of Scientific and Technical Information of China (English)

    Ruxu Zhang; Qian Pan; Beisha Tang; Fufeng Zhang; Xiaobo Li; Shunxiang Huang; Xiaohong Zi; Ting Liu; Sanmei Liu; Xuning Li; Kun Xia

    2014-01-01

    We previously found that the K141N mutation in heat shock protein B8 (HSPB8) was respon-sible for Charcot-Marie-Tooth disease type 2L in a large Chinese family. The objective of the present study was to generate a transgenic mouse model bearing the K141N mutation in the human HSPB8 gene, and to determine whether this K141NHSPB8 transgenic mouse model would manifest the clinical phenotype of Charcot-Marie-Tooth disease type 2L, and consequently be suitable for use in studies of disease pathogenesis. Transgenic mice overexpressing K141NHSPB8 were generated using K141N mutant HSPB8 cDNA cloned into a pCAGGS plasmid driven by a human cytomegalovirus expression system. PCR and western blot analysis conifrmed integra-tion of the K141NHSPB8 gene and widespread expression in tissues of the transgenic mice. The K141NHSPB8 transgenic mice exhibited decreased muscle strength in the hind limbs and impaired motor coordination, but no obvious sensory disturbance at 6 months of age by behavioral assess-ment. Electrophysiological analysis showed that the compound motor action potential amplitude in the sciatic nerve was signiifcantly decreased, but motor nerve conduction velocity remained normal at 6 months of age. Pathological analysis of the sciatic nerve showed reduced myelinated ifber density, notable axonal edema and vacuolar degeneration in K141NHSPB8 transgenic mice, suggesting axonal involvement in the peripheral nerve damage in these animals. These ifndings indicate that the K141NHSPB8 transgenic mouse successfully models Charcot-Marie-Tooth disease type 2L and can be used to study the pathogenesis of the disease.

  7. Design and test of the time transfer by laser link (T2L2) optical subsystem

    Science.gov (United States)

    Vrancken, Patrick; Samain, Etienne; Guillemot, Philippe

    2008-04-01

    We report on the design and test of the optical subsystem of the T2L2 (Time Transfer by Laser Link) space instrument. The T2L2 experiment, developed by OCA and CNES is a next generation optical time transfer system that will allow an improvement1,2 by one to two orders of magnitude as compared to the performances of existing microwave time transfer systems like GPS or Two-Way. The principle is derived from satellite laser ranging (SLR) technology with dedicated space equipment embarked on the satellite Jason 2, scheduled for launch in mid-2008. Satellite Laser Ranging stations (connected to the clocks to be synchronized) emit short laser pulses towards the satellite where they are equally reflected and dated by an onboard event timer. The departure and return of the laser pulses are also timed in the laser stations. The time transfer is derived aposteriori from the data triplets (departure, satellite, return) acquired on the satellite and the respective laser stations. The T2L2 instrument consists of an optical and an electronic subsystem. The optical subsystem is designed such that its field of view (FOV) covers the whole earth for the Jason 2 orbit. It features a linear and a non-linear channel consisting of optical elements and avalanche photodiodes; the linear channel's purpose is threefold: it triggers the whole timing system and measures both the background light and the laser pulse energy. The non-linear channel is for precise timing. We report on the detailed construction of the optical assembly and an exhaustive calibration and performance test campaign in terms of metrology. This test campaign was performed in the clean-room facilities at CNES, Toulouse in March/April 2007 with a dedicated test bed featuring a mode locked laser, variable geometry for different incidence angles and a reference timing system.

  8. Time Transfer by Laser Link The T2L2 Experiment on Jason-2

    Science.gov (United States)

    Samain, E.; Weick, J.; Vrancken, P.; Torre, J.-M.; Mangin, J.-F.; Para, F.; Paris, J.; Albanese, D.; Dalla, R.; Guillemot, Ph.; Petitbon, I.

    2006-06-01

    The new generation of optical time transfer will allow the synchronization of remote ultra stable clocks and the determination of their performances over intercontinental distances. The principle of T2L2 (Time Transfer by Laser Link) is based on laser ranging technique coupled with time-frequency metrology and consists in synchronizing ground and space clocks using short light pulses traveling between the ground and a satellite. The instrument will be integrated to the Jason-2 altimetric satellite billed for launch in 2008. The experiment should enhance the performances of time transfer by one or two magnitudes as compared to existing microwave techniques like GPS and Two-Way.

  9. Search for the standard model Higgs boson in the $H \\to ZZ \\to 2l 2\

    CERN Document Server

    Chatrchyan, Serguei; Sirunyan, Albert M; Tumasyan, Armen; Adam, Wolfgang; Bergauer, Thomas; Dragicevic, Marko; Erö, Janos; Fabjan, Christian; Friedl, Markus; Fruehwirth, Rudolf; Ghete, Vasile Mihai; Hammer, Josef; Hoch, Michael; Hörmann, Natascha; Hrubec, Josef; Jeitler, Manfred; Kiesenhofer, Wolfgang; Krammer, Manfred; Liko, Dietrich; Mikulec, Ivan; Pernicka, Manfred; Rahbaran, Babak; Rohringer, Christine; Rohringer, Herbert; Schöfbeck, Robert; Strauss, Josef; Taurok, Anton; Teischinger, Florian; Wagner, Philipp; Waltenberger, Wolfgang; Walzel, Gerhard; Widl, Edmund; Wulz, Claudia-Elisabeth; Mossolov, Vladimir; Shumeiko, Nikolai; Suarez Gonzalez, Juan; Bansal, Sunil; Benucci, Leonardo; Cornelis, Tom; De Wolf, Eddi A; Janssen, Xavier; Luyckx, Sten; Maes, Thomas; Mucibello, Luca; Ochesanu, Silvia; Roland, Benoit; Rougny, Romain; Selvaggi, Michele; Van Haevermaet, Hans; Van Mechelen, Pierre; Van Remortel, Nick; Van Spilbeeck, Alex; Blekman, Freya; Blyweert, Stijn; D'Hondt, Jorgen; Gonzalez Suarez, Rebeca; Kalogeropoulos, Alexis; Maes, Michael; Olbrechts, Annik; Van Doninck, Walter; Van Mulders, Petra; Van Onsem, Gerrit Patrick; Villella, Ilaria; Charaf, Otman; Clerbaux, Barbara; De Lentdecker, Gilles; Dero, Vincent; Gay, Arnaud; Hammad, Gregory Habib; Hreus, Tomas; Léonard, Alexandre; Marage, Pierre Edouard; Thomas, Laurent; Vander Velde, Catherine; Vanlaer, Pascal; Wickens, John; Adler, Volker; Beernaert, Kelly; Cimmino, Anna; Costantini, Silvia; Garcia, Guillaume; Grunewald, Martin; Klein, Benjamin; Lellouch, Jérémie; Marinov, Andrey; Mccartin, Joseph; Ocampo Rios, Alberto Andres; Ryckbosch, Dirk; Strobbe, Nadja; Thyssen, Filip; Tytgat, Michael; Vanelderen, Lukas; Verwilligen, Piet; Walsh, Sinead; Yazgan, Efe; Zaganidis, Nicolas; Basegmez, Suzan; Bruno, Giacomo; Ceard, Ludivine; De Favereau De Jeneret, Jerome; Delaere, Christophe; Du Pree, Tristan; Favart, Denis; Forthomme, Laurent; Giammanco, Andrea; Grégoire, Ghislain; Hollar, Jonathan; Lemaitre, Vincent; Liao, Junhui; Militaru, Otilia; Nuttens, Claude; Pagano, Davide; Pin, Arnaud; Piotrzkowski, Krzysztof; Schul, Nicolas; Beliy, Nikita; Caebergs, Thierry; Daubie, Evelyne; Alves, Gilvan; Correa Martins Junior, Marcos; De Jesus Damiao, Dilson; Martins, Thiago; Pol, Maria Elena; Henrique Gomes E Souza, Moacyr; Aldá Júnior, Walter Luiz; Carvalho, Wagner; Custódio, Analu; Da Costa, Eliza Melo; De Oliveira Martins, Carley; Fonseca De Souza, Sandro; Matos Figueiredo, Diego; Mundim, Luiz; Nogima, Helio; Oguri, Vitor; Prado Da Silva, Wanda Lucia; Santoro, Alberto; Silva Do Amaral, Sheila Mara; Soares Jorge, Luana; Sznajder, Andre; Souza Dos Anjos, Tiago; Bernardes, Cesar Augusto; De Almeida Dias, Flavia; Tomei, Thiago; De Moraes Gregores, Eduardo; Lagana, Caio; Da Cunha Marinho, Franciole; Mercadante, Pedro G; Novaes, Sergio F; Padula, Sandra; Genchev, Vladimir; Iaydjiev, Plamen; Piperov, Stefan; Rodozov, Mircho; Stoykova, Stefka; Sultanov, Georgi; Tcholakov, Vanio; Trayanov, Rumen; Vutova, Mariana; Dimitrov, Anton; Hadjiiska, Roumyana; Karadzhinova, Aneliya; Kozhuharov, Venelin; Litov, Leander; Pavlov, Borislav; Petkov, Peicho; Bian, Jian-Guo; Chen, Guo-Ming; Chen, He-Sheng; Jiang, Chun-Hua; Liang, Dong; Liang, Song; Meng, Xiangwei; Tao, Junquan; Wang, Jian; Wang, Jian; Wang, Xianyou; Wang, Zheng; Xiao, Hong; Xu, Ming; Zang, Jingjing; Zhang, Zhen; Asawatangtrakuldee, Chayanit; Ban, Yong; Guo, Shuang; Guo, Yifei; Li, Wenbo; Liu, Shuai; Mao, Yajun; Qian, Si-Jin; Teng, Haiyun; Wang, Siguang; Zhu, Bo; Zou, Wei; Cabrera, Andrés; Gomez Moreno, Bernardo; Osorio Oliveros, Andres Felipe; Sanabria, Juan Carlos; Godinovic, Nikola; Lelas, Damir; Plestina, Roko; Polic, Dunja; Puljak, Ivica; Antunovic, Zeljko; Dzelalija, Mile; Kovac, Marko; Brigljevic, Vuko; Duric, Senka; Kadija, Kreso; Luetic, Jelena; Morovic, Srecko; Attikis, Alexandros; Galanti, Mario; Mousa, Jehad; Nicolaou, Charalambos; Ptochos, Fotios; Razis, Panos A; Finger, Miroslav; Finger Jr, Michael; Assran, Yasser; Ellithi Kamel, Ali; Khalil, Shaaban; Mahmoud, Mohammed; Radi, Amr; Hektor, Andi; Kadastik, Mario; Müntel, Mait; Raidal, Martti; Rebane, Liis; Tiko, Andres; Azzolini, Virginia; Eerola, Paula; Fedi, Giacomo; Voutilainen, Mikko; Czellar, Sandor; Härkönen, Jaakko; Heikkinen, Mika Aatos; Karimäki, Veikko; Kinnunen, Ritva; Kortelainen, Matti J; Lampén, Tapio; Lassila-Perini, Kati; Lehti, Sami; Lindén, Tomas; Luukka, Panja-Riina; Mäenpää, Teppo; Peltola, Timo; Tuominen, Eija; Tuominiemi, Jorma; Tuovinen, Esa; Ungaro, Donatella; Wendland, Lauri; Banzuzi, Kukka; Korpela, Arja; Tuuva, Tuure; Sillou, Daniel; Besancon, Marc; Choudhury, Somnath; Dejardin, Marc; Denegri, Daniel; Fabbro, Bernard; Faure, Jean-Louis; Ferri, Federico; Ganjour, Serguei; Givernaud, Alain; Gras, Philippe; Hamel de Monchenault, Gautier; Jarry, Patrick; Locci, Elizabeth; Malcles, Julie; Millischer, Laurent; Rander, John; Rosowsky, André; Shreyber, Irina; Titov, Maksym; Baffioni, Stephanie; Beaudette, Florian; Benhabib, Lamia; Bianchini, Lorenzo; Bluj, Michal; Broutin, Clementine; Busson, Philippe; Charlot, Claude; Daci, Nadir; Dahms, Torsten; Dobrzynski, Ludwik; Elgammal, Sherif; Granier de Cassagnac, Raphael; Haguenauer, Maurice; Miné, Philippe; Mironov, Camelia; Ochando, Christophe; Paganini, Pascal; Sabes, David; Salerno, Roberto; Sirois, Yves; Thiebaux, Christophe; Veelken, Christian; Zabi, Alexandre; Agram, Jean-Laurent; Andrea, Jeremy; Bloch, Daniel; Bodin, David; Brom, Jean-Marie; Cardaci, Marco; Chabert, Eric Christian; Collard, Caroline; Conte, Eric; Drouhin, Frédéric; Ferro, Cristina; Fontaine, Jean-Charles; Gelé, Denis; Goerlach, Ulrich; Juillot, Pierre; Karim, Mehdi; Le Bihan, Anne-Catherine; Van Hove, Pierre; Fassi, Farida; Mercier, Damien; Baty, Clement; Beauceron, Stephanie; Beaupere, Nicolas; Bedjidian, Marc; Bondu, Olivier; Boudoul, Gaelle; Boumediene, Djamel; Brun, Hugues; Chasserat, Julien; Chierici, Roberto; Contardo, Didier; Depasse, Pierre; El Mamouni, Houmani; Falkiewicz, Anna; Fay, Jean; Gascon, Susan; Gouzevitch, Maxime; Ille, Bernard; Kurca, Tibor; Le Grand, Thomas; Lethuillier, Morgan; Mirabito, Laurent; Perries, Stephane; Sordini, Viola; Tosi, Silvano; Tschudi, Yohann; Verdier, Patrice; Viret, Sébastien; Lomidze, David; Anagnostou, Georgios; Beranek, Sarah; Edelhoff, Matthias; Feld, Lutz; Heracleous, Natalie; Hindrichs, Otto; Jussen, Ruediger; Klein, Katja; Merz, Jennifer; Ostapchuk, Andrey; Perieanu, Adrian; Raupach, Frank; Sammet, Jan; Schael, Stefan; Sprenger, Daniel; Weber, Hendrik; Wittmer, Bruno; Zhukov, Valery; Ata, Metin; Caudron, Julien; Dietz-Laursonn, Erik; Erdmann, Martin; Güth, Andreas; Hebbeker, Thomas; Heidemann, Carsten; Hoepfner, Kerstin; Klimkovich, Tatsiana; Klingebiel, Dennis; Kreuzer, Peter; Lanske, Dankfried; Lingemann, Joschka; Magass, Carsten; Merschmeyer, Markus; Meyer, Arnd; Olschewski, Mark; Papacz, Paul; Pieta, Holger; Reithler, Hans; Schmitz, Stefan Antonius; Sonnenschein, Lars; Steggemann, Jan; Teyssier, Daniel; Weber, Martin; Bontenackels, Michael; Cherepanov, Vladimir; Davids, Martina; Flügge, Günter; Geenen, Heiko; Geisler, Matthias; Haj Ahmad, Wael; Hoehle, Felix; Kargoll, Bastian; Kress, Thomas; Kuessel, Yvonne; Linn, Alexander; Nowack, Andreas; Perchalla, Lars; Pooth, Oliver; Rennefeld, Jörg; Sauerland, Philip; Stahl, Achim; Zoeller, Marc Henning; Aldaya Martin, Maria; Behrenhoff, Wolf; Behrens, Ulf; Bergholz, Matthias; Bethani, Agni; Borras, Kerstin; Burgmeier, Armin; Cakir, Altan; Calligaris, Luigi; Campbell, Alan; Castro, Elena; Dammann, Dirk; Eckerlin, Guenter; Eckstein, Doris; Flossdorf, Alexander; Flucke, Gero; Geiser, Achim; Hauk, Johannes; Jung, Hannes; Kasemann, Matthias; Katsas, Panagiotis; Kleinwort, Claus; Kluge, Hannelies; Knutsson, Albert; Krämer, Mira; Krücker, Dirk; Kuznetsova, Ekaterina; Lange, Wolfgang; Lohmann, Wolfgang; Lutz, Benjamin; Mankel, Rainer; Marfin, Ihar; Marienfeld, Markus; Melzer-Pellmann, Isabell-Alissandra; Meyer, Andreas Bernhard; Mnich, Joachim; Mussgiller, Andreas; Naumann-Emme, Sebastian; Olzem, Jan; Petrukhin, Alexey; Pitzl, Daniel; Raspereza, Alexei; Ribeiro Cipriano, Pedro M; Rosin, Michele; Salfeld-Nebgen, Jakob; Schmidt, Ringo; Schoerner-Sadenius, Thomas; Sen, Niladri; Spiridonov, Alexander; Stein, Matthias; Tomaszewska, Justyna; Walsh, Roberval; Wissing, Christoph; Autermann, Christian; Blobel, Volker; Bobrovskyi, Sergei; Draeger, Jula; Enderle, Holger; Erfle, Joachim; Gebbert, Ulla; Görner, Martin; Hermanns, Thomas; Höing, Rebekka Sophie; Kaschube, Kolja; Kaussen, Gordon; Kirschenmann, Henning; Klanner, Robert; Lange, Jörn; Mura, Benedikt; Nowak, Friederike; Pietsch, Niklas; Sander, Christian; Schettler, Hannes; Schleper, Peter; Schlieckau, Eike; Schmidt, Alexander; Schröder, Matthias; Schum, Torben; Stadie, Hartmut; Steinbrück, Georg; Thomsen, Jan; Barth, Christian; Berger, Joram; Chwalek, Thorsten; De Boer, Wim; Dierlamm, Alexander; Dirkes, Guido; Feindt, Michael; Gruschke, Jasmin; Guthoff, Moritz; Hackstein, Christoph; Hartmann, Frank; Heinrich, Michael; Held, Hauke; Hoffmann, Karl-Heinz; Honc, Simon; Katkov, Igor; Komaragiri, Jyothsna Rani; Kuhr, Thomas; Martschei, Daniel; Mueller, Steffen; Müller, Thomas; Niegel, Martin; Nürnberg, Andreas; Oberst, Oliver; Oehler, Andreas; Ott, Jochen; Peiffer, Thomas; Quast, Gunter; Rabbertz, Klaus; Ratnikov, Fedor; Ratnikova, Natalia; Renz, Manuel; Röcker, Steffen; Saout, Christophe; Scheurer, Armin; Schieferdecker, Philipp; Schilling, Frank-Peter; Schmanau, Mike; Schott, Gregory; Simonis, Hans-Jürgen; Stober, Fred-Markus Helmut; Troendle, Daniel; Wagner-Kuhr, Jeannine; Weiler, Thomas; Zeise, Manuel; Ziebarth, Eva Barbara; Daskalakis, Georgios; Geralis, Theodoros; Kesisoglou, Stilianos; Kyriakis, Aristotelis; Loukas, Demetrios; Manolakos, Ioannis; Markou, Athanasios; Markou, Christos; Mavrommatis, Charalampos; Ntomari, Eleni; Gouskos, Loukas; Mertzimekis, Theodoros; Panagiotou, Apostolos; Saoulidou, Niki; Stiliaris, Efstathios; Evangelou, Ioannis; Foudas, Costas; Kokkas, Panagiotis; Manthos, Nikolaos; Papadopoulos, Ioannis; Patras, Vaios; Triantis, Frixos A; Aranyi, Attila; Bencze, Gyorgy; Boldizsar, Laszlo; Hajdu, Csaba; Hidas, Pàl; Horvath, Dezso; Kapusi, Anita; Krajczar, Krisztian; Sikler, Ferenc; Veszpremi, Viktor; Vesztergombi, Gyorgy; Beni, Noemi; Molnar, Jozsef; Palinkas, Jozsef; Szillasi, Zoltan; Karancsi, János; Raics, Peter; Trocsanyi, Zoltan Laszlo; Ujvari, Balazs; Beri, Suman Bala; Bhatnagar, Vipin; Dhingra, Nitish; Gupta, Ruchi; Jindal, Monika; Kaur, Manjit; Kohli, Jatinder Mohan; Mehta, Manuk Zubin; Nishu, Nishu; Saini, Lovedeep Kaur; Sharma, Archana; Singh, Anil; Singh, Jasbir; Singh, Supreet Pal; Ahuja, Sudha; Choudhary, Brajesh C; Kumar, Ashok; Kumar, Arun; Malhotra, Shivali; Naimuddin, Md; Ranjan, Kirti; Sharma, Varun; Shivpuri, Ram Krishen; Banerjee, Sunanda; Bhattacharya, Satyaki; Dutta, Suchandra; Gomber, Bhawna; Jain, Sandhya; Jain, Shilpi; Khurana, Raman; Sarkar, Subir; Choudhury, Rajani Kant; Dutta, Dipanwita; Kailas, Swaminathan; Kumar, Vineet; Mohanty, Ajit Kumar; Pant, Lalit Mohan; Shukla, Prashant; Aziz, Tariq; Ganguly, Sanmay; Guchait, Monoranjan; Gurtu, Atul; Maity, Manas; Majumder, Gobinda; Mazumdar, Kajari; Mohanty, Gagan Bihari; Parida, Bibhuti; Saha, Anirban; Sudhakar, Katta; Wickramage, Nadeesha; Banerjee, Sudeshna; Dugad, Shashikant; Mondal, Naba Kumar; Arfaei, Hessamaddin; Bakhshiansohi, Hamed; Etesami, Seyed Mohsen; Fahim, Ali; Hashemi, Majid; Hesari, Hoda; Jafari, Abideh; Khakzad, Mohsen; Mohammadi, Abdollah; Mohammadi Najafabadi, Mojtaba; Paktinat Mehdiabadi, Saeid; Safarzadeh, Batool; Zeinali, Maryam; Abbrescia, Marcello; Barbone, Lucia; Calabria, Cesare; Chhibra, Simranjit Singh; Colaleo, Anna; Creanza, Donato; De Filippis, Nicola; De Palma, Mauro; Fiore, Luigi; Iaselli, Giuseppe; Lusito, Letizia; Maggi, Giorgio; Maggi, Marcello; Manna, Norman; Marangelli, Bartolomeo; My, Salvatore; Nuzzo, Salvatore; Pacifico, Nicola; Pompili, Alexis; Pugliese, Gabriella; Romano, Francesco; Selvaggi, Giovanna; Silvestris, Lucia; Singh, Gurpreet; Tupputi, Salvatore; Zito, Giuseppe; Abbiendi, Giovanni; Benvenuti, Alberto; Bonacorsi, Daniele; Braibant-Giacomelli, Sylvie; Brigliadori, Luca; Capiluppi, Paolo; Castro, Andrea; Cavallo, Francesca Romana; Cuffiani, Marco; Dallavalle, Gaetano-Marco; Fabbri, Fabrizio; Fanfani, Alessandra; Fasanella, Daniele; Giacomelli, Paolo; Grandi, Claudio; Marcellini, Stefano; Masetti, Gianni; Meneghelli, Marco; Montanari, Alessandro; Navarria, Francesco; Odorici, Fabrizio; Perrotta, Andrea; Primavera, Federica; Rossi, Antonio; Rovelli, Tiziano; Siroli, Gianni; Travaglini, Riccardo; Albergo, Sebastiano; Cappello, Gigi; Chiorboli, Massimiliano; Costa, Salvatore; Potenza, Renato; Tricomi, Alessia; Tuve, Cristina; Barbagli, Giuseppe; Ciulli, Vitaliano; Civinini, Carlo; D'Alessandro, Raffaello; Focardi, Ettore; Frosali, Simone; Gallo, Elisabetta; Gonzi, Sandro; Meschini, Marco; Paoletti, Simone; Sguazzoni, Giacomo; Tropiano, Antonio; Benussi, Luigi; Bianco, Stefano; Colafranceschi, Stefano; Fabbri, Franco; Piccolo, Davide; Fabbricatore, Pasquale; Musenich, Riccardo; Benaglia, Andrea; De Guio, Federico; Di Matteo, Leonardo; Fiorendi, Sara; Gennai, Simone; Ghezzi, Alessio; Malvezzi, Sandra; Manzoni, Riccardo Andrea; Martelli, Arabella; Massironi, Andrea; Menasce, Dario; Moroni, Luigi; Paganoni, Marco; Pedrini, Daniele; Ragazzi, Stefano; Redaelli, Nicola; Sala, Silvano; Tabarelli de Fatis, Tommaso; Buontempo, Salvatore; Carrillo Montoya, Camilo Andres; Cavallo, Nicola; De Cosa, Annapaola; Dogangun, Oktay; Fabozzi, Francesco; Iorio, Alberto Orso Maria; Lista, Luca; Merola, Mario; Paolucci, Pierluigi; Azzi, Patrizia; Bacchetta, Nicola; Bellan, Paolo; Bisello, Dario; Branca, Antonio; Carlin, Roberto; Checchia, Paolo; Dorigo, Tommaso; Dosselli, Umberto; Fanzago, Federica; Gasparini, Fabrizio; Gasparini, Ugo; Gozzelino, Andrea; Kanishchev, Konstantin; Lacaprara, Stefano; Lazzizzera, Ignazio; Margoni, Martino; Mazzucato, Mirco; Meneguzzo, Anna Teresa; Nespolo, Massimo; Perrozzi, Luca; Pozzobon, Nicola; Ronchese, Paolo; Simonetto, Franco; Torassa, Ezio; Tosi, Mia; Vanini, Sara; Zotto, Pierluigi; Zumerle, Gianni; Berzano, Umberto; Gabusi, Michele; Ratti, Sergio P; Riccardi, Cristina; Torre, Paola; Vitulo, Paolo; Biasini, Maurizio; Bilei, Gian Mario; Caponeri, Benedetta; Fanò, Livio; Lariccia, Paolo; Lucaroni, Andrea; Mantovani, Giancarlo; Menichelli, Mauro; Nappi, Aniello; Romeo, Francesco; Santocchia, Attilio; Taroni, Silvia; Valdata, Marisa; Azzurri, Paolo; Bagliesi, Giuseppe; Boccali, Tommaso; Broccolo, Giuseppe; Castaldi, Rino; D'Agnolo, Raffaele Tito; Dell'Orso, Roberto; Fiori, Francesco; Foà, Lorenzo; Giassi, Alessandro; Kraan, Aafke; Ligabue, Franco; Lomtadze, Teimuraz; Martini, Luca; Messineo, Alberto; Palla, Fabrizio; Palmonari, Francesco; Rizzi, Andrea; Serban, Alin Titus; Spagnolo, Paolo; Tenchini, Roberto; Tonelli, Guido; Venturi, Andrea; Verdini, Piero Giorgio; Barone, Luciano; Cavallari, Francesca; Del Re, Daniele; Diemoz, Marcella; Fanelli, Cristiano; Grassi, Marco; Longo, Egidio; Meridiani, Paolo; Micheli, Francesco; Nourbakhsh, Shervin; Organtini, Giovanni; Pandolfi, Francesco; Paramatti, Riccardo; Rahatlou, Shahram; Sigamani, Michael; Soffi, Livia; Amapane, Nicola; Arcidiacono, Roberta; Argiro, Stefano; Arneodo, Michele; Biino, Cristina; Botta, Cristina; Cartiglia, Nicolo; Castello, Roberto; Costa, Marco; Demaria, Natale; Graziano, Alberto; Mariotti, Chiara; Maselli, Silvia; Migliore, Ernesto; Monaco, Vincenzo; Musich, Marco; Obertino, Maria Margherita; Pastrone, Nadia; Pelliccioni, Mario; Potenza, Alberto; Romero, Alessandra; Ruspa, Marta; Sacchi, Roberto; Sola, Valentina; Solano, Ada; Staiano, Amedeo; Vilela Pereira, Antonio; Belforte, Stefano; Cossutti, Fabio; Della Ricca, Giuseppe; Gobbo, Benigno; Marone, Matteo; Montanino, Damiana; Penzo, Aldo; Heo, Seong Gu; Nam, Soon-Kwon; Chang, Sunghyun; Chung, Jin Hyuk; Kim, Dong Hee; Kim, Gui Nyun; Kim, Ji Eun; Kong, Dae Jung; Park, Hyangkyu; Ro, Sang-Ryul; Son, Dong-Chul; Kim, Jae Yool; Kim, Zero Jaeho; Song, Sanghyeon; Jo, Hyun Yong; Choi, Suyong; Gyun, Dooyeon; Hong, Byung-Sik; Jo, Mihee; Kim, Hyunchul; Kim, Tae Jeong; Lee, Kyong Sei; Moon, Dong Ho; Park, Sung Keun; Seo, Eunsung; Sim, Kwang Souk; Choi, Minkyoo; Kang, Seokon; Kim, Hyunyong; Kim, Ji Hyun; Park, Chawon; Park, Inkyu; Park, Sangnam; Ryu, Geonmo; Cho, Yongjin; Choi, Young-Il; Choi, Young Kyu; Goh, Junghwan; Kim, Min Suk; Lee, Byounghoon; Lee, Jongseok; Lee, Sungeun; Seo, Hyunkwan; Yu, Intae; Bilinskas, Mykolas Jurgis; Grigelionis, Ignas; Janulis, Mindaugas; Castilla-Valdez, Heriberto; De La Cruz-Burelo, Eduard; Heredia-de La Cruz, Ivan; Lopez-Fernandez, Ricardo; Magaña Villalba, Ricardo; Martínez-Ortega, Jorge; Sánchez-Hernández, Alberto; Villasenor-Cendejas, Luis Manuel; Carrillo Moreno, Salvador; Vazquez Valencia, Fabiola; Salazar Ibarguen, Humberto Antonio; Casimiro Linares, Edgar; Morelos Pineda, Antonio; Reyes-Santos, Marco A; Krofcheck, David; Bell, Alan James; Butler, Philip H; Doesburg, Robert; Reucroft, Steve; Silverwood, Hamish; Ahmad, Muhammad; Asghar, Muhammad Irfan; Hoorani, Hafeez R; Khalid, Shoaib; Khan, Wajid Ali; Khurshid, Taimoor; Qazi, Shamona; Shah, Mehar Ali; Shoaib, Muhammad; Brona, Grzegorz; Cwiok, Mikolaj; Dominik, Wojciech; Doroba, Krzysztof; Kalinowski, Artur; Konecki, Marcin; Krolikowski, Jan; Bialkowska, Helena; Boimska, Bozena; Frueboes, Tomasz; Gokieli, Ryszard; Górski, Maciej; Kazana, Malgorzata; Nawrocki, Krzysztof; Romanowska-Rybinska, Katarzyna; Szleper, Michal; Wrochna, Grzegorz; Zalewski, Piotr; Almeida, Nuno; Bargassa, Pedrame; David Tinoco Mendes, Andre; Faccioli, Pietro; Ferreira Parracho, Pedro Guilherme; Gallinaro, Michele; Musella, Pasquale; Nayak, Aruna; Pela, Joao; Ribeiro, Pedro Quinaz; Seixas, Joao; Varela, Joao; Vischia, Pietro; Afanasiev, Serguei; Belotelov, Ivan; Bunin, Pavel; Golutvin, Igor; Kamenev, Alexey; Karjavin, Vladimir; Konoplyanikov, Viktor; Kozlov, Guennady; Lanev, Alexander; Moisenz, Petr; Palichik, Vladimir; Perelygin, Victor; Savina, Maria; Shmatov, Sergey; Smirnov, Vitaly; Volodko, Anton; Zarubin, Anatoli; Evstyukhin, Sergey; Golovtsov, Victor; Ivanov, Yury; Kim, Victor; Levchenko, Petr; Murzin, Victor; Oreshkin, Vadim; Smirnov, Igor; Sulimov, Valentin; Uvarov, Lev; Vavilov, Sergey; Vorobyev, Alexey; Vorobyev, Andrey; Andreev, Yuri; Dermenev, Alexander; Gninenko, Sergei; Golubev, Nikolai; Kirsanov, Mikhail; Krasnikov, Nikolai; Matveev, Viktor; Pashenkov, Anatoli; Toropin, Alexander; Troitsky, Sergey; Epshteyn, Vladimir; Erofeeva, Maria; Gavrilov, Vladimir; Kossov, Mikhail; Krokhotin, Andrey; Lychkovskaya, Natalia; Popov, Vladimir; Safronov, Grigory; Semenov, Sergey; Stolin, Viatcheslav; Vlasov, Evgueni; Zhokin, Alexander; Belyaev, Andrey; Boos, Edouard; Dubinin, Mikhail; Dudko, Lev; Ershov, Alexander; Gribushin, Andrey; Kodolova, Olga; Lokhtin, Igor; Markina, Anastasia; Obraztsov, Stepan; Perfilov, Maxim; Petrushanko, Sergey; Sarycheva, Ludmila; Savrin, Viktor; Snigirev, Alexander; Andreev, Vladimir; Azarkin, Maksim; Dremin, Igor; Kirakosyan, Martin; Leonidov, Andrey; Mesyats, Gennady; Rusakov, Sergey V; Vinogradov, Alexey; Azhgirey, Igor; Bayshev, Igor; Bitioukov, Sergei; Grishin, Viatcheslav; Kachanov, Vassili; Konstantinov, Dmitri; Korablev, Andrey; Krychkine, Victor; Petrov, Vladimir; Ryutin, Roman; Sobol, Andrei; Tourtchanovitch, Leonid; Troshin, Sergey; Tyurin, Nikolay; Uzunian, Andrey; Volkov, Alexey; Adzic, Petar; Djordjevic, Milos; Ekmedzic, Marko; Krpic, Dragomir; Milosevic, Jovan; Aguilar-Benitez, Manuel; Alcaraz Maestre, Juan; Arce, Pedro; Battilana, Carlo; Calvo, Enrique; Cerrada, Marcos; Chamizo Llatas, Maria; Colino, Nicanor; De La Cruz, Begona; Delgado Peris, Antonio; Diez Pardos, Carmen; Domínguez Vázquez, Daniel; Fernandez Bedoya, Cristina; Fernández Ramos, Juan Pablo; Ferrando, Antonio; Flix, Jose; Fouz, Maria Cruz; Garcia-Abia, Pablo; Gonzalez Lopez, Oscar; Goy Lopez, Silvia; Hernandez, Jose M; Josa, Maria Isabel; Merino, Gonzalo; Puerta Pelayo, Jesus; Redondo, Ignacio; Romero, Luciano; Santaolalla, Javier; Soares, Mara Senghi; Willmott, Carlos; Albajar, Carmen; Codispoti, Giuseppe; de Trocóniz, Jorge F; Cuevas, Javier; Fernandez Menendez, Javier; Folgueras, Santiago; Gonzalez Caballero, Isidro; Lloret Iglesias, Lara; Piedra Gomez, Jonatan; Vizan Garcia, Jesus Manuel; Brochero Cifuentes, Javier Andres; Cabrillo, Iban Jose; Calderon, Alicia; Chuang, Shan-Huei; Duarte Campderros, Jordi; Felcini, Marta; Fernandez, Marcos; Gomez, Gervasio; Gonzalez Sanchez, Javier; Jorda, Clara; Lobelle Pardo, Patricia; Lopez Virto, Amparo; Marco, Jesus; Marco, Rafael; Martinez Rivero, Celso; Matorras, Francisco; Munoz Sanchez, Francisca Javiela; Rodrigo, Teresa; Rodríguez-Marrero, Ana Yaiza; Ruiz-Jimeno, Alberto; Scodellaro, Luca; Sobron Sanudo, Mar; Vila, Ivan; Vilar Cortabitarte, Rocio; Abbaneo, Duccio; Auffray, Etiennette; Auzinger, Georg; Baillon, Paul; Ball, Austin; Barney, David; Bernet, Colin; Bialas, Wojciech; Bianchi, Giovanni; Bloch, Philippe; Bocci, Andrea; Breuker, Horst; Bunkowski, Karol; Camporesi, Tiziano; Cerminara, Gianluca; Christiansen, Tim; Coarasa Perez, Jose Antonio; Curé, Benoît; D'Enterria, David; De Roeck, Albert; Di Guida, Salvatore; Dobson, Marc; Dupont-Sagorin, Niels; Elliott-Peisert, Anna; Frisch, Benjamin; Funk, Wolfgang; Gaddi, Andrea; Georgiou, Georgios; Gerwig, Hubert; Giffels, Manuel; Gigi, Dominique; Gill, Karl; Giordano, Domenico; Giunta, Marina; Glege, Frank; Gomez-Reino Garrido, Robert; Govoni, Pietro; Gowdy, Stephen; Guida, Roberto; Guiducci, Luigi; Hansen, Magnus; Harris, Philip; Hartl, Christian; Harvey, John; Hegner, Benedikt; Hinzmann, Andreas; Hoffmann, Hans Falk; Innocente, Vincenzo; Janot, Patrick; Kaadze, Ketino; Karavakis, Edward; Kousouris, Konstantinos; Lecoq, Paul; Lenzi, Piergiulio; Lourenco, Carlos; Maki, Tuula; Malberti, Martina; Malgeri, Luca; Mannelli, Marcello; Masetti, Lorenzo; Mavromanolakis, Georgios; Meijers, Frans; Mersi, Stefano; Meschi, Emilio; Moser, Roland; Mozer, Matthias Ulrich; Mulders, Martijn; Nesvold, Erik; Nguyen, Matthew; Orimoto, Toyoko; Orsini, Luciano; Palencia Cortezon, Enrique; Perez, Emmanuelle; Petrilli, Achille; Pfeiffer, Andreas; Pierini, Maurizio; Pimiä, Martti; Piparo, Danilo; Polese, Giovanni; Quertenmont, Loic; Racz, Attila; Reece, William; Rodrigues Antunes, Joao; Rolandi, Gigi; Rommerskirchen, Tanja; Rovelli, Chiara; Rovere, Marco; Sakulin, Hannes; Santanastasio, Francesco; Schäfer, Christoph; Schwick, Christoph; Segoni, Ilaria; Sharma, Archana; Siegrist, Patrice; Silva, Pedro; Simon, Michal; Sphicas, Paraskevas; Spiga, Daniele; Spiropulu, Maria; Stoye, Markus; Tsirou, Andromachi; Veres, Gabor Istvan; Vichoudis, Paschalis; Wöhri, Hermine Katharina; Worm, Steven; Zeuner, Wolfram Dietrich; Bertl, Willi; Deiters, Konrad; Erdmann, Wolfram; Gabathuler, Kurt; Horisberger, Roland; Ingram, Quentin; Kaestli, Hans-Christian; König, Stefan; Kotlinski, Danek; Langenegger, Urs; Meier, Frank; Renker, Dieter; Rohe, Tilman; Sibille, Jennifer; Bäni, Lukas; Bortignon, Pierluigi; Buchmann, Marco-Andrea; Casal, Bruno; Chanon, Nicolas; Chen, Zhiling; Deisher, Amanda; Dissertori, Günther; Dittmar, Michael; Dünser, Marc; Eugster, Jürg; Freudenreich, Klaus; Grab, Christoph; Lecomte, Pierre; Lustermann, Werner; Martinez Ruiz del Arbol, Pablo; Mohr, Niklas; Moortgat, Filip; Nägeli, Christoph; Nef, Pascal; Nessi-Tedaldi, Francesca; Pape, Luc; Pauss, Felicitas; Peruzzi, Marco; Ronga, Frederic Jean; Rossini, Marco; Sala, Leonardo; Sanchez, Ann - Karin; Sawley, Marie-Christine; Starodumov, Andrei; Stieger, Benjamin; Takahashi, Maiko; Tauscher, Ludwig; Thea, Alessandro; Theofilatos, Konstantinos; Treille, Daniel; Urscheler, Christina; Wallny, Rainer; Weber, Hannsjoerg Artur; Wehrli, Lukas; Weng, Joanna; Aguilo, Ernest; Amsler, Claude; Chiochia, Vincenzo; De Visscher, Simon; Favaro, Carlotta; Ivova Rikova, Mirena; Millan Mejias, Barbara; Otiougova, Polina; Robmann, Peter; Snoek, Hella; Verzetti, Mauro; Chang, Yuan-Hann; Chen, Kuan-Hsin; Kuo, Chia-Ming; Li, Syue-Wei; Lin, Willis; Liu, Zong-Kai; Lu, Yun-Ju; Mekterovic, Darko; Volpe, Roberta; Yu, Shin-Shan; Bartalini, Paolo; Chang, Paoti; Chang, You-Hao; Chang, Yu-Wei; Chao, Yuan; Chen, Kai-Feng; Dietz, Charles; Grundler, Ulysses; Hou, George Wei-Shu; Hsiung, Yee; Kao, Kai-Yi; Lei, Yeong-Jyi; Lu, Rong-Shyang; Majumder, Devdatta; Petrakou, Eleni; Shi, Xin; Shiu, Jing-Ge; Tzeng, Yeng-Ming; Wang, Minzu; Adiguzel, Aytul; Bakirci, Mustafa Numan; Cerci, Salim; Dozen, Candan; Dumanoglu, Isa; Eskut, Eda; Girgis, Semiray; Gokbulut, Gul; Hos, Ilknur; Kangal, Evrim Ersin; Karapinar, Guler; Kayis Topaksu, Aysel; Onengut, Gulsen; Ozdemir, Kadri; Ozturk, Sertac; Polatoz, Ayse; Sogut, Kenan; Sunar Cerci, Deniz; Tali, Bayram; Topakli, Huseyin; Uzun, Dilber; Vergili, Latife Nukhet; Vergili, Mehmet; Akin, Ilina Vasileva; Aliev, Takhmasib; Bilin, Bugra; Bilmis, Selcuk; Deniz, Muhammed; Gamsizkan, Halil; Guler, Ali Murat; Ocalan, Kadir; Ozpineci, Altug; Serin, Meltem; Sever, Ramazan; Surat, Ugur Emrah; Yalvac, Metin; Yildirim, Eda; Zeyrek, Mehmet; Deliomeroglu, Mehmet; Gülmez, Erhan; Isildak, Bora; Kaya, Mithat; Kaya, Ozlem; Ozkorucuklu, Suat; Sonmez, Nasuf; Levchuk, Leonid; Bostock, Francis; Brooke, James John; Clement, Emyr; Cussans, David; Flacher, Henning; Frazier, Robert; Goldstein, Joel; Grimes, Mark; Heath, Greg P; Heath, Helen F; Kreczko, Lukasz; Metson, Simon; Newbold, Dave M; Nirunpong, Kachanon; Poll, Anthony; Senkin, Sergey; Smith, Vincent J; Williams, Thomas; Basso, Lorenzo; Bell, Ken W; Belyaev, Alexander; Brew, Christopher; Brown, Robert M; Cockerill, David JA; Coughlan, John A; Harder, Kristian; Harper, Sam; Jackson, James; Kennedy, Bruce W; Olaiya, Emmanuel; Petyt, David; Radburn-Smith, Benjamin Charles; Shepherd-Themistocleous, Claire; Tomalin, Ian R; Womersley, William John; Bainbridge, Robert; Ball, Gordon; Beuselinck, Raymond; Buchmuller, Oliver; Colling, David; Cripps, Nicholas; Cutajar, Michael; Dauncey, Paul; Davies, Gavin; Della Negra, Michel; Ferguson, William; Fulcher, Jonathan; Futyan, David; Gilbert, Andrew; Guneratne Bryer, Arlo; Hall, Geoffrey; Hatherell, Zoe; Hays, Jonathan; Iles, Gregory; Jarvis, Martyn; Karapostoli, Georgia; Lyons, Louis; Magnan, Anne-Marie; Marrouche, Jad; Mathias, Bryn; Nandi, Robin; Nash, Jordan; Nikitenko, Alexander; Papageorgiou, Anastasios; Pesaresi, Mark; Petridis, Konstantinos; Pioppi, Michele; Raymond, David Mark; Rogerson, Samuel; Rompotis, Nikolaos; Rose, Andrew; Ryan, Matthew John; Seez, Christopher; Sparrow, Alex; Tapper, Alexander; Tourneur, Stephane; Vazquez Acosta, Monica; Virdee, Tejinder; Wakefield, Stuart; Wardle, Nicholas; Wardrope, David; Whyntie, Tom; Barrett, Matthew; Chadwick, Matthew; Cole, Joanne; Hobson, Peter R; Khan, Akram; Kyberd, Paul; Leslie, Dawn; Martin, William; Reid, Ivan; Symonds, Philip; Teodorescu, Liliana; Turner, Mark; Hatakeyama, Kenichi; Liu, Hongxuan; Scarborough, Tara; Henderson, Conor; Avetisyan, Aram; Bose, Tulika; Carrera Jarrin, Edgar; Fantasia, Cory; Heister, Arno; St John, Jason; Lawson, Philip; Lazic, Dragoslav; Rohlf, James; Sperka, David; Sulak, Lawrence; Bhattacharya, Saptaparna; Cutts, David; Ferapontov, Alexey; Heintz, Ulrich; Jabeen, Shabnam; Kukartsev, Gennadiy; Landsberg, Greg; Luk, Michael; Narain, Meenakshi; Nguyen, Duong; Segala, Michael; Sinthuprasith, Tutanon; Speer, Thomas; Tsang, Ka Vang; Breedon, Richard; Breto, Guillermo; Calderon De La Barca Sanchez, Manuel; Caulfield, Matthew; Chauhan, Sushil; Chertok, Maxwell; Conway, John; Conway, Rylan; Cox, Peter Timothy; Dolen, James; Erbacher, Robin; Gardner, Michael; Houtz, Rachel; Ko, Winston; Kopecky, Alexandra; Lander, Richard; Mall, Orpheus; Miceli, Tia; Nelson, Randy; Pellett, Dave; Robles, Jorge; Rutherford, Britney; Searle, Matthew; Smith, John; Squires, Michael; Tripathi, Mani; Vasquez Sierra, Ricardo; Andreev, Valeri; Arisaka, Katsushi; Cline, David; Cousins, Robert; Duris, Joseph; Erhan, Samim; Everaerts, Pieter; Farrell, Chris; Hauser, Jay; Ignatenko, Mikhail; Jarvis, Chad; Plager, Charles; Rakness, Gregory; Schlein, Peter; Tucker, Jordan; Valuev, Vyacheslav; Weber, Matthias; Babb, John; Clare, Robert; Ellison, John Anthony; Gary, J William; Giordano, Ferdinando; Hanson, Gail; Jeng, Geng-Yuan; Liu, Hongliang; Long, Owen Rosser; Luthra, Arun; Nguyen, Harold; Paramesvaran, Sudarshan; Sturdy, Jared; Sumowidagdo, Suharyo; Wilken, Rachel; Wimpenny, Stephen; Andrews, Warren; Branson, James G; Cerati, Giuseppe Benedetto; Cittolin, Sergio; Evans, David; Golf, Frank; Holzner, André; Kelley, Ryan; Lebourgeois, Matthew; Letts, James; Macneill, Ian; Mangano, Boris; Padhi, Sanjay; Palmer, Christopher; Petrucciani, Giovanni; Pi, Haifeng; Pieri, Marco; Ranieri, Riccardo; Sani, Matteo; Sfiligoi, Igor; Sharma, Vivek; Simon, Sean; Sudano, Elizabeth; Tadel, Matevz; Tu, Yanjun; Vartak, Adish; Wasserbaech, Steven; Würthwein, Frank; Yagil, Avraham; Yoo, Jaehyeok; Barge, Derek; Bellan, Riccardo; Campagnari, Claudio; D'Alfonso, Mariarosaria; Danielson, Thomas; Flowers, Kristen; Geffert, Paul; Incandela, Joe; Justus, Christopher; Kalavase, Puneeth; Koay, Sue Ann; Kovalskyi, Dmytro; Krutelyov, Vyacheslav; Lowette, Steven; Mccoll, Nickolas; Pavlunin, Viktor; Rebassoo, Finn; Ribnik, Jacob; Richman, Jeffrey; Rossin, Roberto; Stuart, David; To, Wing; Vlimant, Jean-Roch; West, Christopher; Apresyan, Artur; Bornheim, Adolf; Bunn, Julian; Chen, Yi; Di Marco, Emanuele; Duarte, Javier; Gataullin, Marat; Ma, Yousi; Mott, Alexander; Newman, Harvey B; Rogan, Christopher; Timciuc, Vladlen; Traczyk, Piotr; Veverka, Jan; Wilkinson, Richard; Yang, Yong; Zhu, Ren-Yuan; Akgun, Bora; Carroll, Ryan; Ferguson, Thomas; Iiyama, Yutaro; Jang, Dong Wook; Jun, Soon Yung; Liu, Yueh-Feng; Paulini, Manfred; Russ, James; Vogel, Helmut; Vorobiev, Igor; Cumalat, John Perry; Dinardo, Mauro Emanuele; Drell, Brian Robert; Edelmaier, Christopher; Ford, William T; Gaz, Alessandro; Heyburn, Bernadette; Luiggi Lopez, Eduardo; Nauenberg, Uriel; Smith, James; Stenson, Kevin; Ulmer, Keith; Wagner, Stephen Robert; Zang, Shi-Lei; Agostino, Lorenzo; Alexander, James; Chatterjee, Avishek; Eggert, Nicholas; Gibbons, Lawrence Kent; Heltsley, Brian; Hopkins, Walter; Khukhunaishvili, Aleko; Kreis, Benjamin; Mirman, Nathan; Nicolas Kaufman, Gala; Patterson, Juliet Ritchie; Ryd, Anders; Salvati, Emmanuele; Sun, Werner; Teo, Wee Don; Thom, Julia; Thompson, Joshua; Vaughan, Jennifer; Weng, Yao; Winstrom, Lucas; Wittich, Peter; Biselli, Angela; Winn, Dave; Abdullin, Salavat; Albrow, Michael; Anderson, Jacob; Apollinari, Giorgio; Atac, Muzaffer; Bakken, Jon Alan; Bauerdick, Lothar AT; Beretvas, Andrew; Berryhill, Jeffrey; Bhat, Pushpalatha C; Bloch, Ingo; Burkett, Kevin; Butler, Joel Nathan; Chetluru, Vasundhara; Cheung, Harry; Chlebana, Frank; Cihangir, Selcuk; Cooper, William; Eartly, David P; Elvira, Victor Daniel; Esen, Selda; Fisk, Ian; Freeman, Jim; Gao, Yanyan; Gottschalk, Erik; Green, Dan; Gutsche, Oliver; Hanlon, Jim; Harris, Robert M; Hirschauer, James; Hooberman, Benjamin; Jensen, Hans; Jindariani, Sergo; Johnson, Marvin; Joshi, Umesh; Klima, Boaz; Kunori, Shuichi; Kwan, Simon; Leonidopoulos, Christos; Lincoln, Don; Lipton, Ron; Lykken, Joseph; Maeshima, Kaori; Marraffino, John Michael; Maruyama, Sho; Mason, David; McBride, Patricia; Miao, Ting; Mishra, Kalanand; Mrenna, Stephen; Musienko, Yuri; Newman-Holmes, Catherine; O'Dell, Vivian; Pivarski, James; Pordes, Ruth; Prokofyev, Oleg; Schwarz, Thomas; Sexton-Kennedy, Elizabeth; Sharma, Seema; Spalding, William J; Spiegel, Leonard; Tan, Ping; Taylor, Lucas; Tkaczyk, Slawek; Uplegger, Lorenzo; Vaandering, Eric Wayne; Vidal, Richard; Whitmore, Juliana; Wu, Weimin; Yang, Fan; Yumiceva, Francisco; Yun, Jae Chul; Acosta, Darin; Avery, Paul; Bourilkov, Dimitri; Chen, Mingshui; Das, Souvik; De Gruttola, Michele; Di Giovanni, Gian Piero; Dobur, Didar; Drozdetskiy, Alexey; Field, Richard D; Fisher, Matthew; Fu, Yu; Furic, Ivan-Kresimir; Gartner, Joseph; Goldberg, Sean; Hugon, Justin; Kim, Bockjoo; Konigsberg, Jacobo; Korytov, Andrey; Kropivnitskaya, Anna; Kypreos, Theodore; Low, Jia Fu; Matchev, Konstantin; Milenovic, Predrag; Mitselmakher, Guenakh; Muniz, Lana; Remington, Ronald; Rinkevicius, Aurelijus; Schmitt, Michael; Scurlock, Bobby; Sellers, Paul; Skhirtladze, Nikoloz; Snowball, Matthew; Wang, Dayong; Yelton, John; Zakaria, Mohammed; Gaultney, Vanessa; Lebolo, Luis Miguel; Linn, Stephan; Markowitz, Pete; Martinez, German; Rodriguez, Jorge Luis; Adams, Todd; Askew, Andrew; Bochenek, Joseph; Chen, Jie; Diamond, Brendan; Gleyzer, Sergei V; Haas, Jeff; Hagopian, Sharon; Hagopian, Vasken; Jenkins, Merrill; Johnson, Kurtis F; Prosper, Harrison; Sekmen, Sezen; Veeraraghavan, Venkatesh; Weinberg, Marc; Baarmand, Marc M; Dorney, Brian; Hohlmann, Marcus; Kalakhety, Himali; Vodopiyanov, Igor; Adams, Mark Raymond; Anghel, Ioana Maria; Apanasevich, Leonard; Bai, Yuting; Bazterra, Victor Eduardo; Betts, Russell Richard; Callner, Jeremy; Cavanaugh, Richard; Dragoiu, Cosmin; Gauthier, Lucie; Gerber, Cecilia Elena; Hofman, David Jonathan; Khalatyan, Samvel; Kunde, Gerd J; Lacroix, Florent; Malek, Magdalena; O'Brien, Christine; Silkworth, Christopher; Silvestre, Catherine; Strom, Derek; Varelas, Nikos; Akgun, Ugur; Albayrak, Elif Asli; Bilki, Burak; Clarida, Warren; Duru, Firdevs; Griffiths, Scott; Lae, Chung Khim; McCliment, Edward; Merlo, Jean-Pierre; Mermerkaya, Hamit; Mestvirishvili, Alexi; Moeller, Anthony; Nachtman, Jane; Newsom, Charles Ray; Norbeck, Edwin; Olson, Jonathan; Onel, Yasar; Ozok, Ferhat; Sen, Sercan; Tiras, Emrah; Wetzel, James; Yetkin, Taylan; Yi, Kai; Barnett, Bruce Arnold; Blumenfeld, Barry; Bolognesi, Sara; Bonato, Alessio; Fehling, David; Giurgiu, Gavril; Gritsan, Andrei; Guo, Zijin; Hu, Guofan; Maksimovic, Petar; Rappoccio, Salvatore; Swartz, Morris; Tran, Nhan Viet; Whitbeck, Andrew; Baringer, Philip; Bean, Alice; Benelli, Gabriele; Grachov, Oleg; Kenny Iii, Raymond Patrick; Murray, Michael; Noonan, Daniel; Sanders, Stephen; Stringer, Robert; Tinti, Gemma; Wood, Jeffrey Scott; Zhukova, Victoria; Barfuss, Anne-Fleur; Bolton, Tim; Chakaberia, Irakli; Ivanov, Andrew; Khalil, Sadia; Makouski, Mikhail; Maravin, Yurii; Shrestha, Shruti; Svintradze, Irakli; Gronberg, Jeffrey; Lange, David; Wright, Douglas; Baden, Drew; Boutemeur, Madjid; Calvert, Brian; Eno, Sarah Catherine; Gomez, Jaime; Hadley, Nicholas John; Kellogg, Richard G; Kirn, Malina; Kolberg, Ted; Lu, Ying; Marionneau, Matthieu; Mignerey, Alice; Peterman, Alison; Rossato, Kenneth; Rumerio, Paolo; Skuja, Andris; Temple, Jeffrey; Tonjes, Marguerite; Tonwar, Suresh C; Twedt, Elizabeth; Alver, Burak; Bauer, Gerry; Bendavid, Joshua; Busza, Wit; Butz, Erik; Cali, Ivan Amos; Chan, Matthew; Dutta, Valentina; Gomez Ceballos, Guillelmo; Goncharov, Maxim; Hahn, Kristan Allan; Kim, Yongsun; Klute, Markus; Lee, Yen-Jie; Li, Wei; Luckey, Paul David; Ma, Teng; Nahn, Steve; Paus, Christoph; Ralph, Duncan; Roland, Christof; Roland, Gunther; Rudolph, Matthew; Stephans, George; Stöckli, Fabian; Sumorok, Konstanty; Sung, Kevin; Velicanu, Dragos; Wenger, Edward Allen; Wolf, Roger; Wyslouch, Bolek; Xie, Si; Yang, Mingming; Yilmaz, Yetkin; Yoon, Sungho; Zanetti, Marco; Cooper, Seth; Cushman, Priscilla; Dahmes, Bryan; De Benedetti, Abraham; Franzoni, Giovanni; Gude, Alexander; Haupt, Jason; Kao, Shih-Chuan; Klapoetke, Kevin; Kubota, Yuichi; Mans, Jeremy; Pastika, Nathaniel; Rekovic, Vladimir; Rusack, Roger; Sasseville, Michael; Singovsky, Alexander; Tambe, Norbert; Turkewitz, Jared; Cremaldi, Lucien Marcus; Godang, Romulus; Kroeger, Rob; Perera, Lalith; Rahmat, Rahmat; Sanders, David A; Summers, Don; Avdeeva, Ekaterina; Bloom, Kenneth; Bose, Suvadeep; Butt, Jamila; Claes, Daniel R; Dominguez, Aaron; Eads, Michael; Jindal, Pratima; Keller, Jason; Kravchenko, Ilya; Lazo-Flores, Jose; Malbouisson, Helena; Malik, Sudhir; Snow, Gregory R; Baur, Ulrich; Godshalk, Andrew; Iashvili, Ia; Jain, Supriya; Kharchilava, Avto; Kumar, Ashish; Shipkowski, Simon Peter; Smith, Kenneth; Wan, Zongru; Alverson, George; Barberis, Emanuela; Baumgartel, Darin; Chasco, Matthew; Trocino, Daniele; Wood, Darien; Zhang, Jinzhong; Anastassov, Anton; Kubik, Andrew; Mucia, Nicholas; Odell, Nathaniel; Ofierzynski, Radoslaw Adrian; Pollack, Brian; Pozdnyakov, Andrey; Schmitt, Michael; Stoynev, Stoyan; Velasco, Mayda; Won, Steven; Antonelli, Louis; Berry, Douglas; Brinkerhoff, Andrew; Hildreth, Michael; Jessop, Colin; Karmgard, Daniel John; Kolb, Jeff; Lannon, Kevin; Luo, Wuming; Lynch, Sean; Marinelli, Nancy; Morse, David Michael; Pearson, Tessa; Ruchti, Randy; Slaunwhite, Jason; Valls, Nil; Wayne, Mitchell; Wolf, Matthias; Ziegler, Jill; Bylsma, Ben; Durkin, Lloyd Stanley; Hill, Christopher; Killewald, Phillip; Kotov, Khristian; Ling, Ta-Yung; Puigh, Darren; Rodenburg, Marissa; Vuosalo, Carl; Williams, Grayson; Adam, Nadia; Berry, Edmund; Elmer, Peter; Gerbaudo, Davide; Halyo, Valerie; Hebda, Philip; Hegeman, Jeroen; Hunt, Adam; Laird, Edward; Lopes Pegna, David; Lujan, Paul; Marlow, Daniel; Medvedeva, Tatiana; Mooney, Michael; Olsen, James; Piroué, Pierre; Quan, Xiaohang; Raval, Amita; Saka, Halil; Stickland, David; Tully, Christopher; Werner, Jeremy Scott; Zuranski, Andrzej; Acosta, Jhon Gabriel; Huang, Xing Tao; Lopez, Angel; Mendez, Hector; Oliveros, Sandra; Ramirez Vargas, Juan Eduardo; Zatserklyaniy, Andriy; Alagoz, Enver; Barnes, Virgil E; Benedetti, Daniele; Bolla, Gino; Bortoletto, Daniela; De Mattia, Marco; Everett, Adam; Gutay, Laszlo; Hu, Zhen; Jones, Matthew; Koybasi, Ozhan; Kress, Matthew; Laasanen, Alvin T; Leonardo, Nuno; Maroussov, Vassili; Merkel, Petra; Miller, David Harry; Neumeister, Norbert; Shipsey, Ian; Silvers, David; Svyatkovskiy, Alexey; Vidal Marono, Miguel; Yoo, Hwi Dong; Zablocki, Jakub; Zheng, Yu; Guragain, Samir; Parashar, Neeti; Adair, Antony; Boulahouache, Chaouki; Cuplov, Vesna; Ecklund, Karl Matthew; Geurts, Frank JM; Padley, Brian Paul; Redjimi, Radia; Roberts, Jay; Zabel, James; Betchart, Burton; Bodek, Arie; Chung, Yeon Sei; Covarelli, Roberto; de Barbaro, Pawel; Demina, Regina; Eshaq, Yossof; Garcia-Bellido, Aran; Goldenzweig, Pablo; Gotra, Yury; Han, Jiyeon; Harel, Amnon; Miner, Daniel Carl; Petrillo, Gianluca; Sakumoto, Willis; Vishnevskiy, Dmitry; Zielinski, Marek; Bhatti, Anwar; Ciesielski, Robert; Demortier, Luc; Goulianos, Konstantin; Lungu, Gheorghe; Malik, Sarah; Mesropian, Christina; Arora, Sanjay; Atramentov, Oleksiy; Barker, Anthony; Chou, John Paul; Contreras-Campana, Christian; Contreras-Campana, Emmanuel; Duggan, Daniel; Ferencek, Dinko; Gershtein, Yuri; Gray, Richard; Halkiadakis, Eva; Hidas, Dean; Hits, Dmitry; Lath, Amitabh; Panwalkar, Shruti; Park, Michael; Patel, Rishi; Richards, Alan; Rose, Keith; Salur, Sevil; Schnetzer, Steve; Seitz, Claudia; Somalwar, Sunil; Stone, Robert; Thomas, Scott; Cerizza, Giordano; Hollingsworth, Matthew; Spanier, Stefan; Yang, Zong-Chang; York, Andrew; Eusebi, Ricardo; Flanagan, Will; Gilmore, Jason; Kamon, Teruki; Khotilovich, Vadim; Montalvo, Roy; Osipenkov, Ilya; Pakhotin, Yuriy; Perloff, Alexx; Roe, Jeffrey; Safonov, Alexei; Sakuma, Tai; Sengupta, Sinjini; Suarez, Indara; Tatarinov, Aysen; Toback, David; Akchurin, Nural; Bardak, Cemile; Damgov, Jordan; Dudero, Phillip Russell; Jeong, Chiyoung; Kovitanggoon, Kittikul; Lee, Sung Won; Libeiro, Terence; Mane, Poonam; Roh, Youn; Sill, Alan; Volobouev, Igor; Wigmans, Richard; Appelt, Eric; Brownson, Eric; Engh, Daniel; Florez, Carlos; Gabella, William; Gurrola, Alfredo; Issah, Michael; Johns, Willard; Kurt, Pelin; Maguire, Charles; Melo, Andrew; Sheldon, Paul; Snook, Benjamin; Tuo, Shengquan; Velkovska, Julia; Arenton, Michael Wayne; Balazs, Michael; Boutle, Sarah; Conetti, Sergio; Cox, Bradley; Francis, Brian; Goadhouse, Stephen; Goodell, Joseph; Hirosky, Robert; Ledovskoy, Alexander; Lin, Chuanzhe; Neu, Christopher; Wood, John; Yohay, Rachel; Gollapinni, Sowjanya; Harr, Robert; Karchin, Paul Edmund; Kottachchi Kankanamge Don, Chamath; Lamichhane, Pramod; Mattson, Mark; Milstène, Caroline; Sakharov, Alexandre; Anderson, Michael; Bachtis, Michail; Belknap, Donald; Bellinger, James Nugent; Bernardini, Jacopo; Borrello, Laura; Carlsmith, Duncan; Cepeda, Maria; Dasu, Sridhara; Efron, Jonathan; Friis, Evan; Gray, Lindsey; Grogg, Kira Suzanne; Grothe, Monika; Hall-Wilton, Richard; Herndon, Matthew; Hervé, Alain; Klabbers, Pamela; Klukas, Jeffrey; Lanaro, Armando; Lazaridis, Christos; Leonard, Jessica; Loveless, Richard; Mohapatra, Ajit; Ojalvo, Isabel; Pierro, Giuseppe Antonio; Ross, Ian; Savin, Alexander; Smith, Wesley H; Swanson, Joshua

    2012-01-01

    A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.

  10. Surveying the Scope of the SU(2)_L Scalar Septet Sector

    CERN Document Server

    Alvarado, C; Ostdiek, B

    2014-01-01

    Extending the Standard Model by adding a scalar field transforming as a septet under $SU(2)_L$ preserves the $\\rho$ parameter at tree level and can satisfy experimental constraints on the electroweak parameters $S$ and $T$. This work presents the first fully general phenomenological study of such an extension. We examine constraints on the septet model couplings based on electroweak and Higgs observables, and use LHC searches for new physics to bound the mass of the septet to be above $\\sim 400$ GeV at a $95%$ CL.

  11. Surveying the scope of the SU(2) L scalar septet sector

    Science.gov (United States)

    Alvarado, C.; Lehman, L.; Ostdiek, B.

    2014-05-01

    Extending the Standard Model by adding a scalar field transforming as a septet under SU(2) L preserves the ρ parameter at tree level and can satisfy experimental constraints on the electroweak parameters S and T. This work presents the first fully general phenomenological study of such an extension. We examine constraints on the septet model couplings based on electroweak and Higgs observables, and use LHC searches for new physics to bound the mass of the septet to be above ~ 400 GeV at a 95% CL.

  12. Positive Integer Solutions of the Diophantine Equation $x^2 - L_n xy + (-1)^n y^2 = ± 5^r$

    Indian Academy of Sciences (India)

    Refik Keskin; Zafer Şiar

    2014-08-01

    In this paper, we consider the equation $x^2-L_n xy+(-1)^n y^2=± 5^r$ and determine the values of for which the equation has positive integer solutions and . Moreover, we give all positive integer solutions of the equation $x^2-L_n xy+(-1)^n y^2=± 5^r$ when the equation has positive integer solutions.

  13. Timing of accounting information disclosure and informed trading——An empirical study on the time gap between annual and 1st quarterly financial reports and extra abnormal trading volume%会计信息披露实际与内幕交易——基于年报首季披露时差与异常超额交易量的实证研究

    Institute of Scientific and Technical Information of China (English)

    薛爽; 蒋义宏

    2009-01-01

    考虑到资金成本、市场的系统性风险和被监管的可能性,内幕交易者最可能利用两个相隔时间很短的定期报告进行内幕交易.因为这种交易模式最隐蔽,最安全.同时,因承担了高成本和高风险,内幕交易需要巨额的交易量才能获得超额收益.利用内幕交易的这些特征,找到了极好的研究样本(年报亏损下年首季报盈利且年报首季报先后公布的样本)和控制样本(年报亏损下年首季报盈利但年报首季报同时披露的样本或者年报亏损下年首季报仍然亏损且年报首季报先后公布的样本),通过异常的超额交易量验证了内幕交易的存在.研究表明,在信息披露监管政策中,不仅要考虑信息披露的及时性和充分性,还应考虑信息披露过程是否为内幕交易提供了可乘之机.%Considering the cost of capital,systematic risk and the probability of being monitored and punished,informed traders are most likely to conduct informed trading at the small time gap between the disclosure of annual report of year t and 1st quarter reports of year t+1 because the gap is the best and safest time for informed trading.Meanwhile,due to the high cost and risks of informed trading,traders need huge trading volumes to gain abnormal returns.Based on these characteristics of informed trading,a research sample and a control sample are found for this paper.The former refers to companies with loss annual report in year t and profit-making 1st quarter financial report in year t+1 in tandem.The latter refers to companies announced loss in the previous year and and profit-making 1st quarter financial report in year t+1 simultaneously or companies with loss annual report in the year t and loss 1st quarter financial report in year t+1 in tandem.Results confirm the existence of informed trading by measuring "extra abnormal trading volume".Therefore,authors suggest that a good disclosure policy should not only consider the timeliness

  14. Light Propagation Volumes

    OpenAIRE

    Mikulica, Tomáš

    2016-01-01

    Cílem diplomové práce je popsat různé metody výpočtu globálního osvětlení scény včetně techniky Light Propagation Volumes. Pro tuto metodu jsou podrobně popsány všechny tři kroky výpočtu: injekce, propagace a vykreslení. Dále je navrženo několik vlastních rozšíření zlepšující grafickou kvalitu metody. Části návrhu a implementace jsou zaměřeny na popis scény, zobrazovacího systému, tvorby stínů, implementace metody Light Propagation Volumes a navržených rozšíření. Práci uzavírá měření, porovná...

  15. ST2 and IL-33 in pregnancy and pre-eclampsia.

    Directory of Open Access Journals (Sweden)

    Ingrid Granne

    Full Text Available Normal pregnancy is associated with a mild systemic inflammatory response and an immune bias towards type 2 cytokine production, whereas pre-eclampsia is characterized by a more intense inflammatory response, associated with endothelial dysfunction and a type 1 cytokine dominance. Interleukin (IL-33 is a newly described member of the IL-1 family, which binds its receptor ST2L to induce type 2 cytokines. A soluble variant of ST2 (sST2 acts as a decoy receptor to regulate the activity of IL-33. In this study circulating IL-33 and sST2 were measured in each trimester of normal pregnancy and in women with pre-eclampsia. While IL-33 did not change throughout normal pregnancy, or between non-pregnant, normal pregnant or pre-eclamptic women, sST2 was significantly altered. sST2 was increased in the third trimester of normal pregnancy (p<0.001 and was further increased in pre-eclampsia (p<0.001. This increase was seen prior to the onset of disease (p<0.01. Pre-eclampsia is a disease caused by placental derived factors, and we show that IL-33 and ST2 can be detected in lysates from both normal and pre-eclampsia placentas. ST2, but not IL-33, was identified on the syncytiotrophoblast layer, whereas IL-33 was expressed on perivascular tissue. In an in vitro placental perfusion model, sST2 was secreted by the placenta into the 'maternal' eluate, and placental explants treated with pro-inflammatory cytokines or subjected to hypoxia/reperfusion injury release more sST2, suggesting the origin of at least some of the increased amounts of circulating sST2 in pre-eclamptic women is the placenta. These results suggest that sST2 may play a significant role in pregnancies complicated by pre-eclampsia and increased sST2 could contribute to the type 1 bias seen in this disorder.

  16. Apigenin Sensitizes Prostate Cancer Cells to Apo2L/TRAIL by Targeting Adenine Nucleotide Translocase-2

    Science.gov (United States)

    Taniguchi, Tomoyuki; Goi, Wakana; Miki, Tsuneharu; Sakai, Toshiyuki

    2013-01-01

    Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapeutic agent. Recombinant human Apo2L/TRAIL has been under clinical trials, whereas various kinds of malignant tumors have resistance to Apo2L/TRAIL. We and others have shown that several anticancer agents and flavonoids overcome resistance to Apo2L/TRAIL by upregulating death receptor 5 (DR5) in malignant tumor cells. However, the mechanisms by which these compounds induce DR5 expression remain unknown. Here we show that the dietary flavonoid apigenin binds and inhibits adenine nucleotide translocase-2 (ANT2), resulting in enhancement of Apo2L/TRAIL-induced apoptosis by upregulation of DR5. Apigenin and genistein, which are major flavonoids, enhanced Apo2L/TRAIL-induced apoptosis in cancer cells. Apigenin induced DR5 expression, but genistein did not. Using our method identifying the direct targets of flavonoids, we compared the binding proteins of apigenin with those of genistein. We discovered that ANT2 was a target of apigenin, but not genistein. Similarly to apigenin, knockdown of ANT2 enhanced Apo2L/TRAIL-induced apoptosis by upregulating DR5 expression at the post-transcriptional level. Moreover, silencing of ANT2 attenuated the enhancement of Apo2L/TRAIL-induced apoptosis by apigenin. These results suggest that apigenin upregulates DR5 and enhances Apo2L/TRAIL-induced apoptosis by binding and inhibiting ANT2. We propose that ANT2 inhibitors may contribute to Apo2L/TRAIL therapy. PMID:23431365

  17. NASA's New Millennium ST8 Project

    Science.gov (United States)

    Stevens, C. M.; Stocky, J. F.; Nelson, R. M.

    2007-12-01

    NASA's New Millennium Program (NMP) is formulating the Space Technology 8 (ST8) subsystem demonstration mission, which will qualify, on a single spacecraft provided by Orbital Sciences Corporation, four technologies: Thermal Loop, a miniature loop heat pipe system with multiple evaporators; SAILMAST, a gossamer mast; Ultraflex 175, an ultra-lightweight, deployable solar array; and Dependable Multiprocessor, a fault-tolerant COTS processor for onboard science computing. These technologies have been identified by NMP, with input from the space science community, as necessary to enable future NASA space science missions. Examples of previous enabling technologies demonstrated by NMP are the ion engines on Deep Space 1 and the Autonomous Sciencecraft Experiment demonstrated by ST6. The Thermal Loop, provided by NASA's Goddard Space Flight Center will demonstrate that a loop heat pipe with multiple evaporators and condensers can transport large heat loads over long distances without external pumping. It is expected that this technology will enable more precise temperature control decreasing the mass, power, and volume of small remote sensing and surface-based spacecraft. The SAILMAST experiment is a deployable gossamer mast technology, which will validate its load-carrying characteristics by correlating in-flight measurements with analytical predictions. It will enable a new class of missions, which employ solar sail propulsion technology. The Ultraflex 175 will demonstrate the next generation in ultra-lightweight fan-folded flexible solar arrays, providing ultra-high specific power (170-220 W/kg BOL), ultra-compact stowage volume (>33 W/m3), and high deployed stiffness. The result is less mass and volume needed for power generation on future spacecraft. The Dependable Multiprocessor will integrate commercial-off-the-shelf (COTS) processing components and fault-tolerant control algorithms to provide an adaptable, high-performance, on-board science processing platform

  18. Deficiency of long isoforms of Nfe2l1 sensitizes MIN6 pancreatic β cells to arsenite-induced cytotoxicity.

    Science.gov (United States)

    Cui, Qi; Fu, Jingqi; Hu, Yuxin; Li, Yongfang; Yang, Bei; Li, Lu; Sun, Jing; Chen, Chengjie; Sun, Guifan; Xu, Yuanyuan; Zhang, Qiang; Pi, Jingbo

    2017-08-15

    Increasing evidence indicates that chronic inorganic arsenic exposure is associated with type 2 diabetes (T2D), a disease of growing prevalence. Pancreatic β-cells were targeted and damaged by oxidative stress induced by arsenite. We previously showed that nuclear factor erythroid 2 like 2 (Nfe2l2)-deficient pancreatic β-cells were vulnerable to cell damage induced by oxidative stressors including arsenite, due to a muted antioxidant response. Like nuclear factor erythroid 2 like 2 (NFE2L2), NFE2L1 also belongs to the cap 'n' collar (CNC) basic-region leucine zipper (bZIP) transcription factor family, and regulates antioxidant response element (ARE) related genes. Our prior work showed NFE2L1 regulates glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells and isolated islets. In the current study, we demonstrated that MIN6 cells with a specific knockdown of long isoforms of Nfe2l1 (L-Nfe2l1) by lentiviral shRNA (Nfe2l1(L)-KD) were vulnerable to arsenite-induced apoptosis and cell damage. The expression levels of antioxidant genes, such as Gclc, Gclm and Ho-1, and intracellular reactive oxygen species (ROS) levels were not different in Scramble and Nfe2l1(L)-KD cells, while the expression of arsenic metabolism related-genes, such as Gsto1, Gstm1 and Nqo1, increased in Nfe2l1(L)-KD cells with or without arsenite treatment. The up-regulation of arsenic biotransformation genes was due to activated NFE2L2 in Nfe2l1(L)-KD MIN6 cells. Furthermore, the level of intracellular monomethylarsenic (MMA) was higher in Nfe2l1(L)-KD MIN6 cells than in Scramble cells. These results showed that deficiency of L-Nfe2l1 in pancreatic β-cells increased susceptibility to acute arsenite-induced cytotoxicity by promoting arsenic biotransformation and intracellular MMA levels. Copyright © 2017. Published by Elsevier Inc.

  19. Renormalized Volume

    Science.gov (United States)

    Gover, A. Rod; Waldron, Andrew

    2017-09-01

    We develop a universal distributional calculus for regulated volumes of metrics that are suitably singular along hypersurfaces. When the hypersurface is a conformal infinity we give simple integrated distribution expressions for the divergences and anomaly of the regulated volume functional valid for any choice of regulator. For closed hypersurfaces or conformally compact geometries, methods from a previously developed boundary calculus for conformally compact manifolds can be applied to give explicit holographic formulæ for the divergences and anomaly expressed as hypersurface integrals over local quantities (the method also extends to non-closed hypersurfaces). The resulting anomaly does not depend on any particular choice of regulator, while the regulator dependence of the divergences is precisely captured by these formulæ. Conformal hypersurface invariants can be studied by demanding that the singular metric obey, smoothly and formally to a suitable order, a Yamabe type problem with boundary data along the conformal infinity. We prove that the volume anomaly for these singular Yamabe solutions is a conformally invariant integral of a local Q-curvature that generalizes the Branson Q-curvature by including data of the embedding. In each dimension this canonically defines a higher dimensional generalization of the Willmore energy/rigid string action. Recently, Graham proved that the first variation of the volume anomaly recovers the density obstructing smooth solutions to this singular Yamabe problem; we give a new proof of this result employing our boundary calculus. Physical applications of our results include studies of quantum corrections to entanglement entropies.

  20. BOX: One Minute Volume 3

    OpenAIRE

    Butler, Rose

    2009-01-01

    BOX is a digital short originally developed in 2004 documented on a 1920’s box camera. This early moving image work formed the basis of a practice which interrogates our experience of moving image through the remediation of analogue technology with new media. In 2009 it was included in One Minute Volume 3; a programme of artists moving image curated by Kerry Baldry including work by: Tony Hill, Tina Keane, Katherine Meynell, Kayla Parker and Stuart Moore, Dave Griffiths, Marty St Jam...

  1. ST-segment elevation: Distinguishing ST elevation myocardial infarction from ST elevation secondary to nonischemic etiologies

    Institute of Scientific and Technical Information of China (English)

    Alok; Deshpande; Yochai; Birnbaum

    2014-01-01

    The benefits of early perfusion in ST elevation myocardial infarctions(STEMI) are established; howeverearly perfusion of non-ST elevation myocardial infarctions has not been shown to be beneficial. In additionST elevation(STE) caused by conditions other thanacute ischemia is common. Non-ischemic STE may beconfused as STEMI, but can also mask STEMI on electrocardiogram(ECG). As a result, activating the primarypercutaneous coronary intervention(pPCI) protocooften depends on determining which ST elevation patterns reflect transmural infarction due to acute coronary artery thrombosis. Coordination of interpreting theECG in its clinical context and appropriately activatingthe pPCI protocol has proved a difficult task in borderline cases. But its importance cannot be ignored, asreflected in the 2013 American College of CardiologyFoundation/American Heart Association guidelines concerning the treatment of ST elevation myocardial infarction. Multiples strategies have been tested and studiedand are currently being further perfected. No mattethe strategy, at the heart of delivering the best care lies rapid and accurate interpretation of the ECG. Here, we present the different patterns of non-ischemic STE and methods of distinguishing between them. In writing this paper, we hope for quicker and better stratification of patients with STE on ECG, which will lead to be bet-ter outcomes.

  2. An efficient blocking M2L translation for low-frequency fast multipole method in three dimensions

    Science.gov (United States)

    Takahashi, Toru; Shimba, Yuta; Isakari, Hiroshi; Matsumoto, Toshiro

    2016-05-01

    We propose an efficient scheme to perform the multipole-to-local (M2L) translation in the three-dimensional low-frequency fast multipole method (LFFMM). Our strategy is to combine a group of matrix-vector products associated with M2L translation into a matrix-matrix product in order to diminish the memory traffic. For this purpose, we first developed a grouping method (termed as internal blocking) based on the congruent transformations (rotational and reflectional symmetries) of M2L-translators for each target box in the FMM hierarchy (adaptive octree). Next, we considered another method of grouping (termed as external blocking) that was able to handle M2L translations for multiple target boxes collectively by using the translational invariance of the M2L translation. By combining these internal and external blockings, the M2L translation can be performed efficiently whilst preservingthe numerical accuracy exactly. We assessed the proposed blocking scheme numerically and applied it to the boundary integral equation method to solve electromagnetic scattering problems for perfectly electrical conductor. From the numerical results, it was found that the proposed M2L scheme achieved a few times speedup compared to the non-blocking scheme.

  3. First opportunity to synchronize the ILRS network thanks to T2L2 on Jason-2

    Science.gov (United States)

    Exertier, Pierre; Belli, Alexandre; Courde, Clément; Vernotte, François

    2016-07-01

    The Time Transfer by Laser Link (T2L2, on-board the oceanographic satellite Jason-2 at 1335 km) experiment allows us to synchronize remote clocks of Satellite Laser Ranging (SLR) stations throughout the whole ILRS (International Laser Ranging Service) network. We have developed a time transfer processing dedicated to non Common View (CV) cases, i.e. time transfer between stations from the Americas, Asia, Europe and Oceania. The main difficulty is to take into account the complex behaviour of the on-board Ultra Stable Oscillator (USO) over more than 1,500 s and up to a few thousands seconds. By integrating a recently published model describing the frequency responses of the USO to physical effects, as temperature and radiations, we show that it is possible to propagate the phase (time) of the on-board clock for an orbital revolution (1 rev = 6,700 s) or two with an error of a few nanoseconds (ns). Scheme of stages of this process is presented. The non CV time transfer process is applied in order to synchronize a plurality of remote stations involved in the T2L2/Jason-2 tracking by laser. The ground-to-space time transfers which we have processed over recent years (from 2013 to 2015) are all contributing to the development of a synthetic on-board time scale. The resulting ground-to-ground time transfers, computed between remote clocks of SLR stations, show differences of 250-300 ns up to a few microseconds ± 3-4 ns. The T2L2 space experiment is thus the first opportunity to estimate, quasi-instantaneously and to the ns level, time differences between clocks of the SLR stations which form one of the basis of the International Terrestrial Reference Frame (ITRF). This result would help the laser ranging community (time & frequency metrology of stations, analysis centres, and applications to the precise orbit and positioning) to achieve the GGOS (Global Geodetic Observing System) requirements in terms of accuracy and long-term stability of geodetic references.

  4. 急性ST段抬高型心肌梗死患者平均血小板体积的变化及与冠状动脉影像的关系%Mean platelet volume and its association with coronary angiograms in patients with acute ST-segment elevation myocardial infarction

    Institute of Scientific and Technical Information of China (English)

    许文亮; 惠波; 武越; 张纯全; 夏伟; 邵一兵; 王旭

    2012-01-01

    目的:探讨急性ST段抬高型心肌梗死(STEMI)患者平均血小板体积(MPV)变化及与冠脉影像的关系.方法:STEMI患者200例,测定MPV和血生化等实验室指标,行心脏超声检查,阅读急诊冠脉造影结果,分析直接经皮冠脉介入术后梗死相关动脉的血流.选择同期接受冠脉造影但排除冠心病的住院患者200例作为对照.结果:STEMI患者MPV显著高于对照组;校正其它影响因素后,MPV与高密度脂蛋白胆固醇(HDL-C)和左室射血分数(LVEF)呈独立负相关,与冠脉病变积分呈独立正相关;MPV于冠脉多支病变亚组显著高于单支病变亚组,左前降支为梗死相关动脉亚组显著高于左回旋支亚组,梗死相关动脉无自发性开通亚组显著高于自发性开通亚组,直接经皮冠脉介入术后没有达到TIMIⅢ级血流的亚组显著高于达到TIMIⅢ级血流的亚组.结论:STEMI患者MPV显著升高,与冠脉病变严重程度和梗死相关动脉的慢血流有密切关系.%AIM: To detect the changes of mean platelet volume ( MPV) in patients with acute ST-segment elevation myocardial infarction (STEMI) and its association with coronary angiograms. METHODS: A total of 200 patients with STEMI who underwent emergency coronary angiography were enrolled. Admission MPV was measured and cardiac ultrasound examinations were conducted in the first 24 h. Gensini coronary score and infarct-related artery (IRA) flow before and after primary percutaneous coronary intervention (PPCI) were calculated. Two hundred in-hospital patients with non-CAD were used as controls. RESULTS: MPV significantly increased in STEMI patients compared with that in the control group. After adjustment, MPV was negatively correlated with HDL-C and left ventricular ejection (LVEF) but was positively correlated with Gisini coronary score. MPV in multiple lesions subgroup was significantly higher than in the single lesion subgroup and higher in the left anterior descending coronary

  5. Interaction of human TNF and beta2-microglobulin with Tanapox virus-encoded TNF inhibitor, TPV-2L.

    Science.gov (United States)

    Rahman, Masmudur M; Jeng, David; Singh, Rajkumari; Coughlin, Jake; Essani, Karim; McFadden, Grant

    2009-04-10

    Tanapox virus (TPV) encodes and expresses a secreted TNF-binding protein, TPV-2L or gp38, that displays inhibitory properties against TNF from diverse mammalian species, including human, monkey, canine and rabbit. TPV-2L also has sequence similarity with the MHC-class I heavy chain and interacts differently with human TNF as compared to the known cellular TNF receptors or any of the known virus-encoded TNF receptor homologs derived from many poxviruses. In order to determine the TNF binding region in TPV-2L, various TPV-2L C-terminal truncations and internal deletions were created and the muteins were expressed using recombinant baculovirus vectors. C-terminal deletions from TPV-2L resulted in reduced binding affinity for human TNF and specific mutants of TNF that discriminate between TNF-R1 and TNF-R2. However, deletion of C-terminal 42 amino acid residues totally abolished the binding of human TNF and its mutants. Removal of any of the predicted internal domains resulted in a mutant TPV-2L protein incapable of binding to human TNF. Deletion of C-terminal residues also affected the ability of TPV-2L to block TNF-induced cellular cytotoxicity. In addition to TNF, TPV-2L can also form complexes with human beta2-microglobulin to form a novel macromolecular complex. In summary, the TPV-2L protein is a bona fide MHC-1 heavy chain family member that binds and inhibits human TNF in a fashion very distinct from other known poxvirus-encoded TNF inhibitors, and also can form a novel complex with the human MHC-1 light chain, beta2-microglobulin.

  6. 81st Annual Meeting of the Psychometric Society

    CERN Document Server

    Wiberg, Marie; Culpepper, Steven; Douglas, Jeffrey; Wang, Wen-Chung

    2017-01-01

    This proceedings volume compiles and expands on selected and peer reviewed presentations given at the 81st Annual Meeting of the Psychometric Society (IMPS), organized by the University of North Carolina at Greensboro, and held in Asheville, North Carolina, July 11th to 17th, 2016. IMPS is one of the largest international meetings focusing on quantitative measurement in psychology, education, and the social sciences, both in terms of participants and number of presentations. The meeting built on the Psychometric Society's mission to share quantitative methods relevant to psychology, addressing a diverse set of psychometric topics including item response theory, factor analysis, structural equation modeling, time series analysis, mediation analysis, cognitive diagnostic models, and multi-level models. Selected presenters were invited to revise and expand their contributions and to have them peer reviewed and published in this proceedings volume. Previous volumes to showcase work from the Psychometric Society�...

  7. Finslerian dipolar modulation of the CMB power spectra at scales 2 < l < 600

    Energy Technology Data Exchange (ETDEWEB)

    Li, Xin [Chongqing University, Department of Physics, Chongqing (China); Chinese Academy of Sciences, CAS Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Beijing (China); Lin, Hai-Nan [Chongqing University, Department of Physics, Chongqing (China)

    2017-05-15

    A common explanation for the CMB power asymmetry is to introduce a dipolar modulation at the stage of inflation, where the primordial power spectrum is spatially varying. If the universe in the stage of inflation is Finslerian, and if the Finsler spacetime is non-reversible under parity flip, x → -x, then a three dimensional spectrum which is a function of wave vector and direction is valid. In this paper, a three dimensional primordial power spectrum with preferred direction is derived in the framework of Finsler spacetime. It is found that the amplitude of dipolar modulation is related to the Finslerian parameter, which in turn is a function of wave vector. The angular correlation coefficients are presented, and the numerical results for the anisotropic correlation coefficients over the multipole range 2 < l < 600 are given. (orig.)

  8. Limb girdle muscular dystrophy type 2L presenting as necrotizing myopathy.

    Science.gov (United States)

    Schneider, Ilka; Stoltenburg, Gisela; Deschauer, Marcus; Winterholler, Martin; Hanisch, Frank

    2014-05-01

    Recessive mutations in the ANO5 gene, encoding anoctamin 5, cause proximal limb girdle muscular dystrophy (LGMD2L), Miyoshi-type distal myopathy (MM3) and asymptomatic hyper- CKemia. We report a woman with exertion-induced myalgia and weakness in the hip girdle manifesting at the age of 40. Creatine kinase (CK) was increased 20-fold. Histologically the dominating feature was necrotizing myopathy, but long-term immunosuppressive therapy did not change CK level or myopathic symptoms. Molecular genetic investigation led to the finding of the homozygous ANO5 c.191dupA mutation. This is a report of a muscular dystrophy due to ANO5 mutation presenting histologically as necrotizing myopathy. For this reason our finding extends the histological spectrum of myopathies due to ANO5 mutations as well as the possible differential diagnoses for necrotizing myopathy.

  9. Improved dark matter search results from PICO-2L Run 2

    Energy Technology Data Exchange (ETDEWEB)

    Amole, C.; et al.

    2016-03-21

    New data are reported from a second run of the 2-liter PICO-2L C3F8 bubble chamber with a total exposure of 129 kg-days at a thermodynamic threshold energy of 3.3 keV. These data show that measures taken to control particulate contamination in the superheated fluid resulted in the absence of the anomalous background events observed in the first run of this bubble chamber. One single nuclear-recoil event was observed in the data, consistent both with the predicted background rate from neutrons and with the observed rate of unambiguous multiple-bubble neutron scattering events. The chamber exhibits the same excellent electron-recoil and alpha decay rejection as was previously reported. These data provide the most stringent direct detection constraints on weakly interacting massive particle (WIMP)-proton spin-dependent scattering to date for WIMP masses <50 GeV/c2.

  10. Study of weak vacuum polarization in $Z \\to 2l \\gamma$

    CERN Document Server

    Zhabin, Viktor

    2017-01-01

    The goal of the work was to perform a search of weak vacuum polarization in the channel $Z \\to 2l \\gamma$ using $20 \\text{ fb}^{-1}$ of $pp$ collision data collected by the ATLAS experiment in 2012 at 8 TeV. The ratio of the distribution of an invariant mass of $l\\gamma$ obtained from experimental data to the MC distribution from the experimental data was used for the search of the effect. Total significance of weak vacuum polarization signal in the invariant mass distribution of $l \\gamma$ in only one of four channels has some significance. First studies indicate that an evidence of about $3.5 \\sigma$ can be reached. The parameters, amplitude and phase, determined from the fit are different in each channel and thus inconclusive.

  11. Improved dark matter search results from PICO-2L Run 2

    Science.gov (United States)

    Amole, C.; Ardid, M.; Arnquist, I. J.; Asner, D. M.; Baxter, D.; Behnke, E.; Bhattacharjee, P.; Borsodi, H.; Bou-Cabo, M.; Brice, S. J.; Broemmelsiek, D.; Clark, K.; Collar, J. I.; Cooper, P. S.; Crisler, M.; Dahl, C. E.; Das, M.; Debris, F.; Fallows, S.; Farine, J.; Felis, I.; Filgas, R.; Fines-Neuschild, M.; Girard, F.; Giroux, G.; Hall, J.; Harris, O.; Hoppe, E. W.; Jackson, C. M.; Jin, M.; Krauss, C. B.; Lafrenière, M.; Laurin, M.; Lawson, I.; Leblanc, A.; Levine, I.; Lippincott, W. H.; Mann, E.; Martin, J. P.; Maurya, D.; Mitra, P.; Olson, S.; Neilson, R.; Noble, A. J.; Plante, A.; Podviianiuk, R. B.; Priya, S.; Robinson, A. E.; Ruschman, M.; Scallon, O.; Sonnenschein, A.; Starinski, N.; Štekl, I.; Vázquez-Jáuregui, E.; Wells, J.; Wichoski, U.; Zacek, V.; Zhang, J.; PICO Collaboration

    2016-03-01

    New data are reported from a second run of the 2-liter PICO-2L C3 F8 bubble chamber with a total exposure of 129 kg-days at a thermodynamic threshold energy of 3.3 keV. These data show that measures taken to control particulate contamination in the superheated fluid resulted in the absence of the anomalous background events observed in the first run of this bubble chamber. One single nuclear-recoil event was observed in the data, consistent both with the predicted background rate from neutrons and with the observed rate of unambiguous multiple-bubble neutron scattering events. The chamber exhibits the same excellent electron-recoil and alpha decay rejection as was previously reported. These data provide the most stringent direct detection constraints on weakly interacting massive particle (WIMP)-proton spin-dependent scattering to date for WIMP masses <50 GeV /c2 .

  12. Improved Dark Matter Search Results from PICO-2L Run-2

    CERN Document Server

    Amole, C; Arnquist, I J; Asner, D M; Baxter, D; Behnke, E; Bhattacharjee, P; Borsodi, H; Bou-Cabo, M; Brice, S J; Broemmelsiek, D; Clark, K; Collar, J I; Cooper, P S; Crisler, M; Dahl, C E; Das, M; Debris, F; Fallows, S; Farine, J; Felis, I; Filgas, R; Fines-Neuschild, M; Girard, F; Giroux, G; Hall, J; Harris, O; Hoppe, E W; Jackson, C M; Jin, M; Krauss, C B; Lafrenière, M; Laurin, M; Lawson, I; Leblanc, A; Levine, I; Lippincott, W H; Mann, E; Martin, J P; Maurya, D; Mitra, P; Olson, S; Neilson, R; Noble, A J; Plante, A; Podviianiuk, R B; Priya, S; Robinson, A E; Ruschman, M; Scallon, O; Sonnenschein, A; Starinski, N; Štekl, I; Vázquez-Jáuregui, E; Wells, J; Wichoski, U; Zacek, V; Zhang, J

    2016-01-01

    New data are reported from a second run of the 2-liter PICO-2L C$_3$F$_8$ bubble chamber with a total exposure of 129$\\,$kg-days at a thermodynamic threshold energy of 3.3$\\,$keV. These data show that measures taken to control particulate contamination in the superheated fluid resulted in the absence of the anomalous background events observed in the first run of this bubble chamber. One single nuclear-recoil event was observed in the data, consistent both with the predicted background rate from neutrons and with the observed rate of unambiguous multiple-bubble neutron scattering events. The chamber exhibits the same excellent electron-recoil and alpha decay rejection as was previously reported. These data provide the most stringent direct detection constraints on WIMP-proton spin-dependent scattering to date for WIMP masses $<$ 50$\\,$GeV/c$^2$.

  13. Electronic structure and first hyperpolarizability of poly(2-L-alanine-3-sodium nitrate (I)) crystals

    Indian Academy of Sciences (India)

    A Duarte Moller

    2014-10-01

    Poly(2-L-alanine-3-sodium nitrate (I)), -LASN, crystals have been grown by slow evaporation at room temperature. The nominal size of the crystals obtained by the method was of 500 nm. The UV–Vis spectrum shows a wide range, where absorption is lacking around 532 nm, which is required in order to have the second harmonic emission, when an incident radiation of 1064 nm strikes on the crystal. This guarantees the possible use of the crystal in visible light applications. The transparent nature of the crystal in the visible and infrared regions within the transmission spectrum confirms the nonlinear optical properties of the crystal. Additionally, Fourier transform infrared spectroscopy displays its functional groups which correspond to the poly(2-L-alanine-3-sodium nitrate (I)), where the presence of nitrates in the lattice generally can be identified by their characteristic signature within the 1660–1625, 1300–1255, 870–833 and 763–690 cm-1 range. Single crystal diffraction was carried out in order to determine atomic structure and lattice parameter. Structural parameters were = 5.388(9) Å, = 9.315(15) Å and = 13.63(2) Å. The structure of poly(2-Lalanine-3-sodium nitrate (I)) shown by single crystal diffraction shows an asymmetric unit consisting of one sodium and one nitrate ion and one L-alanine molecule. The coordination geometry around the sodium atom was trigonal bipyramidal, with three bidentate nitrate anions coordinating through their oxygen atoms and two L-alanine molecules, each coordinating through one carboxyl oxygen atom. Electronic structure was obtained by using the Becke–Lee–Yang–Part and Hartree–Fock approximations with hybrid exchangecorrelation three-parameter functional and G-311**G() basis set. Theoretical and experimental results were compared and discussed as having an excellent agreement among them.

  14. Biological dosimetry after H2O2/L-histidine treatment

    Science.gov (United States)

    Hausmann, Michael; Lentfer, Heiko; Wolf, Dietmar; Bauer, Eckhard; Aldinger, Klaus; Greulich, Karl-Otto; Cremer, Christoph G.

    1998-01-01

    In biological dosimetry after radiation or chemical exposure, it has been well established to estimate exposure doses from the relative rate of aberrant chromosomes, especially dicentric chromosomes in a given number of cells. For this purpose, dose-efficiency curves depending on laboratory parameters (e.g. preparation technique, analysis procedure etc.) have to be measured under standard conditions. For statistical reasons, a high number of chromosomes or cells, respectively, has to be evaluated. For a Chinese hamster cell line (CO60) as a typical model system in mutation research, a dose efficiency relation after H2O2/L-histidine treatment of the cells was determined using the Heidelberg slit-scan flow fluorometer. This technique has the advantage that several thousand chromosomes can be automatically analyzed in a very short time. As expected, for low doses of H2O2/L-histidine exposure, a nearly linear dependence of the relative number of dicentric chromosomes to the concentration of H2O2 was obtained. In order to correlate the relative number of dicentric chromosomes to the relative number of double strand breaks, the cells were analyzed by the technique of the neutral comet assay. The dose dependent `tail moment' obtained from the comet assay also showed a linear behavior. This confirmed the results obtained by slit-scan flow fluorometry. Furthermore, the linear dependence of the dose efficiency curve was well compatible to results obtained by visual counting by means of a fluorescence microscope. In this case chromosome 1 of the Chinese hamster cell line DON was specifically labelled by fluorescence in situ hybridization.

  15. The Danish St. Croix Project

    DEFF Research Database (Denmark)

    J. Douma, Michael; Rasmussen, Anders Bo

    2014-01-01

    Working from previously unknown sources in Danish archives, this article establishes for the first time the important role that the island of St. Croix played in the Lincoln Administration’s considerations on colonizing African Americans abroad. The paper argues that U.S. Secretary of State William...

  16. Tele2-l läheb järelejõudmiseks veel aastaid / Sami Seppänen

    Index Scriptorium Estoniae

    Seppänen, Sami

    2006-01-01

    Elisa juhatuse esimees Sami Seppänen kommenteerib Tele2 turunduskampaaniat, mis pakub äriklientidele tasuta kõnesid, kuid nendib, et Tele2-l on investeerimisel ja tugijaamade püstitamisel siiski arenguruumi

  17. On the Equation $x^{2^l+1}+x+a=0$ over $\\mathrm{GF}(2^k)$ (Extended Version)

    CERN Document Server

    Helleseth, Tor

    2009-01-01

    In this paper, the polynomials $P_a(x)=x^{2^l+1}+x+a$ with $a\\in\\mathrm{GF}(2^k)$ are studied. New criteria for the number of zeros of $P_a(x)$ in $\\mathrm{GF}(2^k)$ are proved. In particular, a criterion for $P_a(x)$ to have exactly one zero in $\\mathrm{GF}(2^k)$ when $\\gcd(l,k)=1$ is formulated in terms of the values of permutation polynomials introduced by Dobbertin. We also study the affine polynomial $a^{2^l}x^{2^{2l}}+x^{2^l}+ax+1$ which is closely related to $P_a(x)$. In many cases, explicit expressions for calculating zeros of these polynomials are provided.

  18. On the Equation $x^{2^l+1}+x+a=0$ over $\\mathrm{GF}(2^k)$ (Extended Version)

    OpenAIRE

    Helleseth, Tor; Kholosha, Alexander

    2008-01-01

    In this paper, the polynomials $P_a(x)=x^{2^l+1}+x+a$ with $a\\in\\mathrm{GF}(2^k)$ are studied. New criteria for the number of zeros of $P_a(x)$ in $\\mathrm{GF}(2^k)$ are proved. In particular, a criterion for $P_a(x)$ to have exactly one zero in $\\mathrm{GF}(2^k)$ when $\\gcd(l,k)=1$ is formulated in terms of the values of permutation polynomials introduced by Dobbertin. We also study the affine polynomial $a^{2^l}x^{2^{2l}}+x^{2^l}+ax+1$ which is closely related to $P_a(x)$. In many cases, ex...

  19. A direct comparison between two independently calibrated time transfer techniques: T2L2 and GPS Common-Views

    Science.gov (United States)

    Rovera, G. D.; Abgrall, M.; Courde, C.; Exertier, P.; Fridelance, P.; Guillemot, Ph; Laas-Bourez, M.; Martin, N.; Samain, E.; Sherwood, R.; Torre, J.-M.; Uhrich, P.

    2016-06-01

    We present a direct comparison between two satellite time transfer techniques on independently calibrated links: Time Transfer by Laser Link (T2L2) and Common-Views (CV) of satellites from the Global Positioning System (GPS) constellation. The GPS CV and T2L2 links between three European laboratories where independently calibrated against the same reference point of the local timescales. For all the links the mean values of the differences between GPS CV and T2L2 are equal or below 240 ps, with standard deviations below 500 ps, mostly due to GPS CV. Almost all deviations from 0 ns are within the combined uncertainty estimates. Despite the weak number of common points obtained, due to the fact that T2L2 is weather dependent, these results are providing an unprecedented sub-ns consistency between two independently calibrated microwave and optical satellite time transfer techniques.

  20. The imitation switch ATPase Snf2l is required for superovulation and regulates Fgl2 in differentiating mouse granulosa cells.

    Science.gov (United States)

    Pépin, David; Paradis, François; Perez-Iratxeta, Carol; Picketts, David J; Vanderhyden, Barbara C

    2013-06-01

    Imitation switch (ISWI) proteins are catalytic subunits of chromatin remodeling complexes that alter nucleosome positioning by hydrolyzing ATP to regulate access to DNA. In mice, there are two paralogs, SNF2-homolog (SNF2H) and SNF2-like (SNF2L), which participate in different complexes and have contrasting patterns of expression. Here we investigate the role of SNF2L in ovaries by characterizing a mouse bearing an inactivating deletion of exon 6 that disrupts the ATPase domain. Snf2l mutant mice produce significantly fewer eggs than control mice when superovulated. Gonadotropin stimulation leads to a significant deficit in secondary follicles and an increase in abnormal antral follicles. Mutant females also failed to induce fibrinogen-like 2 (Fgl2) in response to human chorionic gonadotropin (hCG) stimulation, while overexpression of SNF2L was sufficient to drive its expression in granulosa cells. SNF2L was also shown to directly interact with the nuclear receptor co-activator flightless I (FLI-I) as shown by immunoprecipitation. These results begin to establish a role for SNF2L in the precise coordination of gene expression in granulosa cells during folliculogenesis and its broader implications in fertility.

  1. Team Danmarks støttekoncept

    DEFF Research Database (Denmark)

    Storm, Rasmus K.

    Evaluering af Team Danmarks støttekoncept 2005-2008 med omfattende analyser af Team Danmarks virke, dets støttekoncept og de samarbejdsrelationer med specialforbund, udøvere, politisk valgte ledere, trænere mv., som udmøntningen af støttekonceptet forudsætter. Herunder analyse af...

  2. 78 FR 19632 - Special Local Regulations; St. Thomas Carnival Watersport Activities, Charlotte Amalie Harbor; St...

    Science.gov (United States)

    2013-04-02

    ... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulations; St. Thomas Carnival... waters of Charlotte Amalie Harbor in St Thomas, USVI during the St. Thomas Carnival Watersport Activities... navigable waters of the United States during the St Thomas Carnival Watersport Activities. On April 21, 2013...

  3. Structural heart disease and ST2: cross-sectional and longitudinal associations with echocardiography.

    Science.gov (United States)

    deFilippi, Christopher; Daniels, Lori B; Bayes-Genis, Antoni

    2015-04-01

    To further explore the potential role of sST2 in the progression of cardiac disease, this section reviews both the associations with cross-sectional findings and longitudinal changes in cardiac structure and function measured by echocardiography and cardiac magnetic resonance imaging with sST2 levels in a variety of patient populations with or at-risk for cardiovascular disease. In a Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department substudy in patients with acute dyspnea, sST2 levels were found associated with left ventricular ejection fraction (LVEF), and both estimated right ventricular (RV) systolic pressure and RV hypokinesis. In a large cohort of ambulatory patients referred for echocardiograms, sST2 was predominantly associated with RV and not LV structural findings. In contrast, in the Framingham Heart Study, a community cohort of >3,300 participants, sST2 was not associated with either echocardiographic finding, although in the Cardiovascular Health Study, sST2 appeared strongly associated with the presence of diastolic dysfunction. Little evidence exists on the relation of sST2 levels with longitudinal change in cardiac structure and function. A substudy of Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) evaluated the association among LV remodeling (defined as an increase in LV end-systolic and -diastolic volumes), sST2, and the benefit of eplerenone and found that sST2 levels were good surrogates of left ventricular remodeling. In the same line, the ProBNP Outpatient Tailored Chronic Heart Failure (PROTECT) study found that more time spent with an sST2 level less than the cutoff of 35 ng/L identified patients with a greater probability of a decrease in LV diastolic index over 1 year.

  4. ST Support for LHC Experiments

    CERN Document Server

    Principe, R

    2001-01-01

    A couple of years ago, ST division created a first structure for the support of the LHC experiments, aiming to co-ordinate all the activities which traditionally were in the divisional mandate, like civil engineering, cooling and ventilation cranes and transports, electricity, etc. A picture of the last few months activity, mainly concentrated on the CMS experience, shows that synergies between project managers, personnel involved and group structures can strongly improve the service level in the specific divisional domains. A closer collaboration also seemed to facilitate the development of further opportunities tied to the competence available in the groups and of great interest to the experiments, like the participation of the design of the cooling system of several sub-detectors for the compact muon solenoid, as TK, EE, EB, SE, etc. The exponential increase of the demand confirms the divisional support as a real CERN need in this area, but also pushes ST to understand this dynamic environment and follow t...

  5. St. Lucia; Debt Sustainability Analysis

    OpenAIRE

    International Monetary Fund

    2003-01-01

    This paper presents a debt sustainability analysis for St. Lucia. The medium-term scenario prepared by the IMF staff assumes continued fiscal consolidation and thus is compatible with sustainable debt levels even in the presence of adverse economic shocks. Stress tests show that stabilizing the debt/GDP ratio for the public sector at around the levels prevailing in 2002/03 would allow the absorption of economic shocks without generating unstable debt dynamics. Most temporary shocks would, how...

  6. The MMPI-2 L scale, reporting uncommon virtue, and predicting police performance.

    Science.gov (United States)

    Weiss, Peter A; Vivian, James E; Weiss, William U; Davis, Robert D; Rostow, Cary D

    2013-02-01

    The present study investigated the use of the Minnesota Multiphasic Personality Inventory (MMPI)-2 L (Lie) scale in the preemployment selection of police officers. In a prior article, Weiss, Davis, Rostow, and Kinsman (2003) found that high L scale scores are associated with a number of performance problems in law enforcement officers. These investigators recommended a L scale raw score cutoff of 8 when making hiring decisions. The present study sought to explore the usefulness of this recommendation by analyzing data from 4348 officers who had taken the MMPI-2 as a condition of preemployment and had follow-up data on performance provided by their supervisors. Results indicated that officers with L scale raw scores of 8 or higher had significantly more performance problems than those who had scores of 7 or below. Similar results were obtained when cut points of 7 and 9 were used. These results were robust insofar as they remained significant when other factors potentially related to the L scale, particularly level of education, ethnicity, and scores on the 10 MMPI-2 Clinical Scales, were controlled for in the analyses. Implications of these findings for police psychological evaluations are discussed.

  7. The vulnerability of gender on determiners in L1, 2L1 and L2 acquisition

    Directory of Open Access Journals (Sweden)

    Elisabeth van der Linden

    2009-01-01

    Full Text Available The acquisition of gender has been reported to be problematic for some groups of learners acquiring Germanic or Romance languages. It has been shown that L1 learners do better in gender acquisition than others, like bilingual children, child L2 learners and adult L2 learners. The reason for these differences is however not always clear. In this paper, we study the acquisition of gender on determiners by different groups of learners. We concentrate on the acquisition of French, Italian, Spanish and Dutch. The picture from a literature survey shows that contradictory results have been found. We suggest that the ‘vulnerability’ of this particular domain of grammar has to do with interacting factors in the acquisition. Among them are the specific characteristics of the language or languages involved, like the semantic and morphophonological characteristics of the nouns in each language, but also the quantity and quality of input, and the cross-linguistic influence exercised by one language on the other in a 2L1 or L2 setting. Instruction also seems to play a role.

  8. Acute Coronary Syndrome and ST Segment Monitoring.

    Science.gov (United States)

    Carey, Mary G

    2016-09-01

    Acute coronary syndrome (ACS) is caused by a critical obstruction of a coronary artery because of atherosclerotic coronary artery disease. Three specific conditions are included: ST elevation myocardial infarction, non-ST elevation myocardial infarction, and unstable angina. The ST segment on the electrocardiogram is a sensitive and specific marker of myocardial ischemia and infarction; however, ST segment deviation is regional not global, thus the ECG lead must be placed over the affected region of the myocardium. This article describes ACS and infarction and the use of ST segment monitoring to detect these conditions.

  9. EDITORIAL: The 21st Nordic Semiconductor Meeting

    Science.gov (United States)

    2006-09-01

    This Topical Issue contains works presented at the 21st Nordic Semiconductor Meeting (21NSM) held at Sundvolden, Norway, 18-19 August 2005. The institutions supporting 21NSM were: University of Oslo, SINTEF, the Norwegian Defense Research Establishment and Vestfold University College. The Nordic Semiconductor Meeting has become an international forum that has been held every other year in a relay fashion in Denmark, Finland, Iceland, Norway and Sweden. The focus of the meeting has been on original research and science being carried out on semiconductor materials, devices and systems. Reports on industrial activity have usually been featured at the meetings. The topics have ranged from fundamental research on point defects in a semiconductor to system architecture of semiconductor electronic devices. For the last five meetings the proceedings have been printed in a dedicated volume of Physica Scripta in the Topical Issue series. The papers in this Topical Issue have undergone critical peer review and we wish to thank the reviewers and the authors for their cooperation, which has been instrumental in meeting the expected high standards of the series. The range of topics covered by this volume is broad, reflecting the call for papers; most of the papers have an element of materials science and the largest portion of these deal with other semiconductor materials other than silicon. The 21NSM was supported by the following sponsors: Renewable Energy Corporation (REC), EMF III-V Innovations (EMF), and the Nordic Research Board (NordForsk). Terje G Finstad Department of Physics, University of Oslo, Norway Andrej Y Kuznetsov and Bengt G Svensson Centre for Materials Science and Nanotechnology, University of Oslo, Norway

  10. Fgfr3 is a transcriptional target of Ap2delta and Ash2l-containing histone methyltransferase complexes.

    Directory of Open Access Journals (Sweden)

    Cheryl C Tan

    Full Text Available Polycomb (PcG and trithorax (trxG proteins play important roles in establishing lineage-specific genetic programs through induction of chromatin modifications that lead to gene silencing or activation. Previously, we described an association between the MLL/SET1 complexes and a highly restricted, gene-specific DNA-binding protein Ap2delta that is required for recruitment of the MLL/SET1 complex to target Hoxc8 specifically. Here, we reduced levels of Ap2delta and Ash2l in the neuroblastoma cell line, Neuro2A, and analyzed their gene expression profiles using whole-genome mouse cDNA microarrays. This analysis yielded 42 genes that are potentially co-regulated by Ap2delta and Ash2l, and we have identified evolutionarily conserved Ap2-binding sites in 20 of them. To determine whether some of these were direct targets of the Ap2delta-Ash2l complex, we analyzed several promoters for the presence of Ap2delta and Ash2l by chromatin immunoprecipitation (ChIP. Among the targets we screened, we identified Fgfr3 as a direct transcriptional target of the Ap2delta-Ash2l complex. Additionally, we found that Ap2delta is necessary for the recruitment of Ash2l-containing complexes to this promoter and that this recruitment leads to trimethylation of lysine 4 of histone H3 (H3K4me3. Thus, we have identified several candidate targets of complexes containing Ap2delta and Ash2l that can be used to further elucidate their roles during development and showed that Fgfr3 is a novel direct target of these complexes.

  11. Dynamic computer simulation of the Fort St. Vrain steam turbines

    Energy Technology Data Exchange (ETDEWEB)

    Conklin, J.C.

    1983-01-01

    A computer simulation is described for the dynamic response of the Fort St. Vrain nuclear reactor regenerative intermediate- and low-pressure steam turbines. The fundamental computer-modeling assumptions for the turbines and feedwater heaters are developed. A turbine heat balance specifying steam and feedwater conditions at a given generator load and the volumes of the feedwater heaters are all that are necessary as descriptive input parameters. Actual plant data for a generator load reduction from 100 to 50% power (which occurred as part of a plant transient on November 9, 1981) are compared with computer-generated predictions, with reasonably good agreement.

  12. Renormalized Volume

    CERN Document Server

    Gover, A Rod

    2016-01-01

    For any conformally compact manifold with hypersurface boundary we define a canonical renormalized volume functional and compute an explicit, holographic formula for the corresponding anomaly. For the special case of asymptotically Einstein manifolds, our method recovers the known results. The anomaly does not depend on any particular choice of regulator, but the coefficients of divergences do. We give explicit formulae for these divergences valid for any choice of regulating hypersurface; these should be relevant to recent studies of quantum corrections to entanglement entropies. The anomaly is expressed as a conformally invariant integral of a local Q-curvature that generalizes the Branson Q-curvature by including data of the embedding. In each dimension this canonically defines a higher dimensional generalization of the Willmore energy/rigid string action. We show that the variation of these energy functionals is exactly the obstruction to solving a singular Yamabe type problem with boundary data along the...

  13. Perennial snow and ice volumes on Iliamna Volcano, Alaska, estimated with ice radar and volume modeling

    Science.gov (United States)

    Trabant, Dennis C.

    1999-01-01

    The volume of four of the largest glaciers on Iliamna Volcano was estimated using the volume model developed for evaluating glacier volumes on Redoubt Volcano. The volume model is controlled by simulated valley cross sections that are constructed by fitting third-order polynomials to the shape of the valley walls exposed above the glacier surface. Critical cross sections were field checked by sounding with ice-penetrating radar during July 1998. The estimated volumes of perennial snow and glacier ice for Tuxedni, Lateral, Red, and Umbrella Glaciers are 8.6, 0.85, 4.7, and 0.60 cubic kilometers respectively. The estimated volume of snow and ice on the upper 1,000 meters of the volcano is about 1 cubic kilometer. The volume estimates are thought to have errors of no more than ?25 percent. The volumes estimated for the four largest glaciers are more than three times the total volume of snow and ice on Mount Rainier and about 82 times the total volume of snow and ice that was on Mount St. Helens before its May 18, 1980 eruption. Volcanoes mantled by substantial snow and ice covers have produced the largest and most catastrophic lahars and floods. Therefore, it is prudent to expect that, during an eruptive episode, flooding and lahars threaten all of the drainages heading on Iliamna Volcano. On the other hand, debris avalanches can happen any time. Fortunately, their influence is generally limited to the area within a few kilometers of the summit.

  14. Genetic association of LMAN2L gene in schizophrenia and bipolar disorder and its interaction with ANK3 gene polymorphism.

    Science.gov (United States)

    Lim, Chor Hong; Zain, Shamsul Mohd; Reynolds, Gavin P; Zain, Mohd Aizat; Roffeei, Siti Norsyuhada; Zainal, Nor Zuraida; Kanagasundram, Sharmilla; Mohamed, Zahurin

    2014-10-03

    Recent studies have shown that bipolar disorder (BPD) and schizophrenia (SZ) share some common genetic risk factors. This study aimed to examine the association between candidate single nucleotide polymorphisms (SNPs) identified from genome-wide association studies (GWAS) and risk of BPD and SZ. A total of 715 patients (244 BPD and 471 SZ) and 593 controls were genotyped using the Sequenom MassARRAY platform. We showed a positive association between LMAN2L (rs6746896) and risk of both BPD and SZ in a pooled population (P-value=0.001 and 0.009, respectively). Following stratification by ethnicity, variants of the ANK3 gene (rs1938516 and rs10994336) were found to be associated with BPD in Malays (P-value=0.001 and 0.006, respectively). Furthermore, an association exists between another variant of LMAN2L (rs2271893) and SZ in the Malay and Indian ethnic groups (P-value=0.003 and 0.002, respectively). Gene-gene interaction analysis revealed a significant interaction between the ANK3 and LMAN2L genes (empirical P=0.0107). Significant differences were shown between patients and controls for two haplotype frequencies of LMAN2L: GA (P=0.015 and P=0.010, for BPD and SZ, respectively) and GG (P=0.013 for BPD). Our study showed a significant association between LMAN2L and risk of both BPD and SZ.

  15. Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Yong; Wan, Bingbing; Wang, Kevin C.; Cao, Fang; Yang, Yuting; Protacio, Angeline; Dou, Yali; Chang, Howard Y.; Lei, Ming (Michigan-Med); (HHMI)

    2011-09-06

    Ash2L is a core component of the MLL family histone methyltransferases and has an important role in regulating the methylation of histone H3 on lysine 4. Here, we report the crystal structure of the N-terminal domain of Ash2L and reveal a new function of Ash2L. The structure shows that Ash2L contains an atypical PHD finger that does not have histone tail-binding activity. Unexpectedly, the structure shows a previously unrecognized winged-helix motif that directly binds to DNA. The DNA-binding-deficient mutants of Ash2L reduced Ash2L localization to the HOX locus. Strikingly, a single mutation in Ash2L{sub WH} (K131A) breaks the chromatin domain boundary, suggesting that Ash2L also has a role in chromosome demarcation.

  16. Sub-ns time transfer consistency: a direct comparison between GPS CV and T2L2

    Science.gov (United States)

    Exertier, P.; Samain, E.; Courde, C.; Aimar, M.; Torre, J. M.; Rovera, G. D.; Abgrall, M.; Uhrich, P.; Sherwood, R.; Herold, G.; Schreiber, U.; Guillemot, P.

    2016-12-01

    This paper presents a direct comparison between two satellite time transfer techniques: common-view (CV) of satellites from the global positioning system (GPS) constellation, and time transfer by laser link (T2L2) through the low orbiting satellite Jason-2. We describe briefly both techniques, together with two independent relative calibration campaigns of the links involving four European laboratories. Between the same remote time scale reference points, the mean values of the calibrated differences between GPS CV and T2L2 are below 240 ps, with standard deviations below 500 ps, mostly due to GPS CV. Almost all sample deviations from 0 ns are within the combined uncertainty estimates. Despite the relatively small number of common points obtained, due to the fact that T2L2 is weather dependent, these results provide an unprecedented sub-ns consistency between two independently calibrated microwave and optical satellite time transfer techniques.

  17. Strict reaction and substrate specificity of AGXT2L1, the human O-phosphoethanolamine phospho-lyase.

    Science.gov (United States)

    Schiroli, Davide; Cirrincione, Simona; Donini, Stefano; Peracchi, Alessio

    2013-07-01

    Dysregulated expression of the AGXT2L1 gene has been associated to neuropsychiatric disorders. Recently the gene product was shown to possess O-phosphoethanolamine phospho-lyase activity. We here analyze the specificity of AGXT2L1 in terms of both reaction and substrate. We show that the enzyme, despite having evolved from a transaminase ancestor, is at least 500-fold more active as a lyase than as an aminotransferase. Furthermore, the lyase reaction is very selective for O-phosphoethanolamine, strongly discriminating against closely related compounds, and we dissect the factors that contribute to such narrow substrate specificity. Overall, AGXT2L1 function appears to be rigidly confined to phospholipid metabolism, which is altered in neuropsychiatric disturbances. Copyright © 2013 International Union of Biochemistry and Molecular Biology, Inc.

  18. Current regulators for I/SUP 2/L circuits to be operated from low-voltage power supplies

    DEFF Research Database (Denmark)

    Bruun, Erik; Hansen, Ole

    1980-01-01

    A new bandgap current reference is described which can be used to control the injector current of I/SUP 2/L circuits for supply voltages down to about 1 V. For small currents the total injector current is obtained as a mirror of the reference current. For large injector currents the current control...... is performed by a series regulator which compares the injector current of one I/SUP 2/L gate to the reference current. The described reference current can be adjusted to give a variation with temperature of about 60 ppm/°C over the temperature range -10 to +70°C. However, in some applications a nonzero......, but well controlled temperature coefficient is desired. It is shown how a temperature stable ring oscillator with I/SUP 2/L gates can be constructed by tailoring the temperature dependence of the supply current appropriately....

  19. The haplotype of UBE2L3 gene is associated with Hashimoto's thyroiditis in a Chinese Han population.

    Science.gov (United States)

    Wang, Yu; Zhu, Yuan-feng; Wang, Qiong; Xu, Jing; Yan, Ni; Xu, Jian; Shi, Liang-feng; He, Shuang-tao; Zhang, Jin-an

    2016-04-19

    The ubiquitin conjugating enzyme E2L3 (UBE2L3) gene is associated with susceptibility to many autoimmune diseases. The aim of this study was to investigate the association between UBE2L3 gene and autoimmune thyroid diseases (AITDs) and their clinical phenotypes. We genotyped five single-nucleotide polymorphisms (SNPs) rs131654, rs5754217, rs2298428, rs140489 and rs5998672 of UBE2L3 gene in case groups including 1028 patients with AITDs [676 cases of Graves' disease (GD) and 352 cases of Hashimoto's thyroiditis (HT)] and control group including 897 healthy individuals. The genotyping was performed with the method of polymerase chain reaction-ligase detection reaction (PCR-LDR). The frequencies of allele and genotype of five SNPs in gene UBE2L3 showed no statistically significant difference between case groups and control group, respectively. Moreover, no significant differences in frequencies of allele and genotype of five SNPs of the gene were found between clinical subphenotypes of AITDs and control group. Such subphenotypes included GD, HT, and thyroid associated ophthalmopathy (TAO). The negative results were also found in the frequency of other haplotypes of the gene except the haplotype of TCGGC, which was significantly higher in HT group than in control group (P = 0.031, OR = 1.441). The present findings indicate that TCGGC haplotype is associated with an increased risk of HT and UBE2L3 gene is likely to be a susceptibility factor to HT in a Chinese Han population.

  20. St. James Hospital. Lutcher, Louisiana

    Directory of Open Access Journals (Sweden)

    Curtis & Davis, Arquitectos

    1958-05-01

    Full Text Available Un hospital debe estar proyectado, especialmente, para la comodidad y el cuidado de los enfermos. Atendiendo a este postulado, en el hospital St. James se ha buscado que los dormitorios se orienten al sur, y que desde ellos puedan apreciarse a través de amplias superficies acristaladas, la belleza del paisaje circundante. El gran ventanal corrido que compone la fachada meridional está protegido con parteluces giratorios verticales, que cada paciente puede abrir o cerrar a voluntad desde la misma cama.

  1. Effects of exogenous recombinant bovine somatotropin (rbST on hematological indices of Kundhi buffalo male calves.

    Directory of Open Access Journals (Sweden)

    Khuhro AP

    2016-06-01

    Full Text Available The aim of present research was assessment of the rbST effects on hematological indices and also its optimum safe dose in kundhi buffalo male calves for beef production. The calves were divided into three groups, with or without rbST treatment. The rbST administered intramuscularly during fortnight, for eleven weeks with an interval of two weeks. Then blood samples were collected at the end of eleven weeks for analysis. In comparison with group A and B, red blood cells count, hemoglobin, mean corpuscular hemoglobin concentration, platelets count and mean corpuscular volume indices were significantly (P<0.05 higher. There was no significant effect on mean corpuscular hemoglobin, erythrocyte sedimentation rate and packed cell volume. The white blood cells in rbST treated groups (P<0.05 increased, and this increase was attributed due to increase in neutrophil number. However, there was non-significant effect of rbST on eosinophils, basophils, monocytes and lymphocytes between all groups. It was concluded from outcomes that rbST produced dose dependent effect on hematological values in kundi buffaloe calves and no adversely higher values were observed that determine polycethemia or leukocytosis. It is therefore suggested that rbST can be used at the dose rate of 1mg/kg b.w. as growth promoter in Kundhi buffaloe calves.

  2. St. John's wort - an overview.

    Science.gov (United States)

    Linde, Klaus

    2009-06-01

    This article aims to summarize the current state of knowledge on St. John's wort (Hypericum perforatum L.) which is one of the oldest and best investigated medicinal herbs. Dried alcoholic extracts are the most important preparations on the market although a variety of other preparations are available. Depressive disorders according to modern diagnostic standards are the best known and most widely investigated indication although the more traditional, broader indication of 'psycho-vegetative disorders, depressive disorders, anxiety and/or nervous agitation', including diagnoses such as somatoform disorders, might more adequately describe what Hypericum extracts are actually used for by many practitioners. The exact mechanisms of action are still unclear, but the available research clearly shows that various bioactive constituents contribute to the clinical effects reported, often in a synergistic manner. Hypericum extracts have consistently shown activity in pharmacological models related to antidepressant effects. Randomized clinical trials show that Hypericum extracts are more effective than placebo and similarly effective as standard antidepressants while having better tolerability in the acute treatment of major depressive episodes. The most important risk associated with Hypericum extracts are interactions with other drugs. Therefore, physicians need to be informed whether their patients take St. John's wort products. If the risk of interactions is adequately taken into account, high quality Hypericum extracts are an effective and safe tool in the hand of qualified health profession-als in primary care.

  3. Støj fra installationer

    DEFF Research Database (Denmark)

    Kristensen, J.; Ovesen, K.

    Generende støj fra installationer er ikke noget nyt fænomen, men det er først i de senere år erkendt, at støj ikke er et naturfænomen, som beboerne bare skal finde sig i. De lovmæssige krav til bekæmpelse af støjproblemerne er af nyere dato og er endnu på mange områder ret ufuldkomne. Anvisningen...

  4. Bioethanol Production by Calcium Alginate-Immobilised St1 Yeast System: Effects of Size of Beads, Ratio and Concentration

    Directory of Open Access Journals (Sweden)

    Masniroszaime Md Zain

    2011-12-01

    Full Text Available Immobilized yeast-cell technology posses several advantages in bioethanol production due to its potential to increase the ethanol yield by eliminating unit process used. Thus, process expenses in cell recovery and reutilization can be minimised. The aim of this study is to investigate the influence of three parameters (substrate concentrations, size of alginate beads and ratio of volume of beads to volume of medium on local isolated yeast (ST1 which immobilized using calcium alginate fermentation system. The most affected ethanol production by calcium alginate-immobilised ST1 yeast system were ratio of volume of the beads to the volume of substrate and concentration of LBS. Highest theoretical yield, 78% was obtained in ST1-alginate beads with the size of beads 0.5cm, ratio volume of beads to the volume of LBS media 0.4 and 150g/l concentration of LBS.ABSTRAK: Teknologi sel yis pegun memiliki beberapa kelebihan dalam penghasilan bioetanol kerana ia berpotensi meningkatkan pengeluaran etanol dengan menyingkirkan unit proses yang digunakan. Maka, proses pembiayaan dalam perolehan sel dan penggunaan semula boleh dikurangkan. Tujuan kajian ini adalah untuk mengkaji pengaruh tiga parameter (kepekatan substrat, saiz manik alginat dan nisbah isipadu manik terhadap isipadu bahantara ke atas sel tempatan terasing (local isolated yeast (ST1 yang dipegun menggunakan sistem penapaian kalsium alginat. Penghasilan etanol yang paling berkesan dengan menggunakan sistem yis ST1 kalsium alginat-pegun adalah dengan kadar nisbah isipadu manik terhadap isipadu substrat dan kepekatan LBS. Kadar hasil teori tertinggi iaitu 78% didapati menerusi manik alginat-ST1 dengan saiz manik 0.5cm, nisbah isipadu 0.4 terhadap perantara LBS dan kepekatan LBS sebanyak 150g/l. Normal 0 false false false EN-US X-NONE X-NONE

  5. The Effectiveness of D2L System: An Evaluation of Teaching-Learning Process in the Kingdom of Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Mohammed Al-Shehri

    2017-01-01

    Full Text Available High quality education could be achieved through an e-learning system as it increases the educational information accessibility, service availability and accuracy when compared to a conventional face-to-face teaching-learning approach. However, user acceptance is one of the key essentials for adoption and success of e-learning system. Many studies revealed that use of D2L application is one of the best tool in the adoption of teaching and learning methodologies and the effectiveness of this application has gained a demand within the last few years. This paper investigates the feasibility of applying UTAUT model on Desire2Learn (D2L e-learning system in KSA. The main objective of this study is to evaluate the efficiency of D2L (e-learning system based on students acceptance. Questionaire method was employed to accomplish this study. Based on the (UTAUT model the impact of trust on the adoption of e-learning systems’ services from students’ perception was studied. Feedback was collected from 213 students to carry out the study. The results of this study indicates that the services offered by D2L System has significant weightage on teaching-learning process in Saudi Arabia from the student perspective.

  6. Facile preparation of superparamagnetic Fe3O4/poly(St-co-MPS)/SiO2 composite particles with high magnetization by introduction of silanol groups.

    Science.gov (United States)

    Yan, Feng; Li, Jun; Fu, Rong; Lu, Ziyang; Yang, Wensheng

    2009-10-01

    Fe3O4/poly(St-co-MPS) particles were prepared by encapsulation of Fe3O4 nanoparticles into copolymers of styrene (St) and 3-trimethoxysilylpropylmethacrylate (MPS) (poly(St-co-MPS)) prepared by miniemulsion copolymerization. It is found that the structure of the Fe3O4/poly(St-co-MPS)/SiO2 composite particles prepared by direct silica deposition on surface of the Fe3O4/poly(St-co-MPS) particles is dependent on the volume fraction of MPS used in the copolymerization. It is identified that the surface of the Fe3O4/poly(St-co-MPS) particles becomes more negatively charged with increased volume fraction of MPS used in the copolymerization, attributed to the increased amount of the silanol groups on the particles surface. Introduction of silanol groups on the particle surface is effective to improve the dispersibility of the Fe3O4/poly(St-co-MPS) particles and their compatibility with silica, allowing the facile preparation of Fe3O4/poly(St-co-MPS)/SiO2 composite particles with defined core-shell structure. The as-prepared Fe3O4/poly(St-co-MPS)/SiO2 composite particles show high magnetization, for example, saturation magnetization of the particles with average size of 140 nm and 6 nm silica shell is as high as 45 emu/g at 300 K.

  7. Conversion Tables. Volume 2, Dewey-LC. Second Edition.

    Science.gov (United States)

    Scott, Mona L.

    This volume contains tables that list Dewey Decimal classification numbers (i.e., call numbers) with corresponding Library of Congress classification numbers and related Library of Congress subject headings. Materials referenced in the conversion tables are the 21st edition of the "Dewey Decimal Classification", the most current edition…

  8. Conversion Tables. Volume 1, LC-Dewey. Second Edition.

    Science.gov (United States)

    Scott, Mona L.

    This volume contains tables that list Library of Congress classification numbers (i.e., call numbers) with corresponding Dewey Decimal classification numbers and related Library of Congress subject headings. Materials referenced in the conversion tables are the 21st edition of the "Dewey Decimal Classification," the most current edition…

  9. Low Vital Capacity and Electrocardiographic ST-T Abnormalities in Asymptomatic Adults

    Directory of Open Access Journals (Sweden)

    Kei Nakajima

    2012-01-01

    Full Text Available Studies have shown that low forced vital capacity (LFVC is associated with atherosclerosis. However, it is unclear whether LFVC is associated with resting electrocardiographic ST-T abnormalities, a common finding that is prognostic for cardiovascular events. Therefore, pulmonary functions, ST-T abnormalities defined with Minnesota Code, and cardiometabolic risk factors were examined in a cross-sectional study of 1,653 asymptomatic adults without past history of coronary heart diseases. The prevalence of diabetes, metabolic syndrome, and ST-T abnormalities significantly increased with decreasing percent of predicted forced vital capacity (%PFVC. ST-T abnormalities were observed in 73 subjects (4.4% in total. Multiple logistic regression analysis showed that, compared with the highest quartile of %PFVC (≥99.7%, the lowest quartile of %PFVC (≤84.2% was persistently associated with ST-T abnormalities even after further adjustment for diabetes or metabolic syndrome (odds ratio (95%CI: 2.44 (1.16–5.14 and 2.42 (1.15–5.10, resp.. Similar trends were observed when subjects were divided into quartiles according to percent of predicted forced expiratory volume in 1 second (FEV1, but not the ratio of FEV1/FVC. In conclusion, LFVC may be associated with ST-T abnormalities independent of metabolic abnormalities in asymptomatic adults, suggesting a plausible link between impaired pulmonary defects and cardiovascular diseases.

  10. Revised tephra volumes for Cascade Range volcanoes

    Science.gov (United States)

    Nathenson, Manuel

    2017-07-01

    Isopach maps from tephra eruptions from Mount St. Helens were reported in Carey et al. (1995) and for tephra eruptions from Glacier Peak in Gardner et al. (1998). For exponential thinning, the isopach data only define a single slope on a log thickness versus square root of area plot. Carey et al. (1995) proposed a model that was used to estimate a second slope, and volumes were presented in both studies using this model. A study by Sulpizio (2005) for estimating the second slope and square root of area where the lines intersect involves a systematic analysis of many eruptions to provide correlation equations. The purpose of this paper is to recalculate the volumes of Cascades eruptions and compare results from the two methods. In order to gain some perspective on the methods for estimating the second slope, we use data for thickness versus distance beyond the last isopach that are available for some of the larger eruptions in the Cascades. The thickness versus square root of area method is extended to thickness versus distance by developing an approximate relation between the two assuming elliptical isopachs with the source at one of the foci. Based on the comparisons made between the Carey et al. (1995) and Sulpizio (2005) methods, it is felt that the later method provides a better estimate of the second slope. For Mount St. Helens, the estimates of total volume using the Sulpizio (2005) method are generally smaller than those using the Carey et al. (1995) method. For the volume estimates of Carey et al. (1995), the volume of the May 18, 1980, eruption of Mount St. Helens is smaller than six of the eight previous eruptions. With the new volumes using the Sulpizio (2005) method, the 1980 eruption is smaller in volume than the upper end of the range for only three of the layers (Wn, Ye, and Yn) and is the same size as layer We. Thus the 1980 eruption becomes representative of the mid-range of volumes rather than being in the lower range.

  11. Revised tephra volumes for Cascade Range volcanoes

    Science.gov (United States)

    Nathenson, Manuel

    2017-01-01

    Isopach maps from tephra eruptions from Mount St. Helens were reported in Carey et al. (1995) and for tephra eruptions from Glacier Peak in Gardner et al. (1998). For exponential thinning, the isopach data only define a single slope on a log thickness versus square root of area plot. Carey et al. (1995) proposed a model that was used to estimate a second slope, and volumes were presented in both studies using this model. A study by Sulpizio (2005) for estimating the second slope and square root of area where the lines intersect involves a systematic analysis of many eruptions to provide correlation equations. The purpose of this paper is to recalculate the volumes of Cascades eruptions and compare results from the two methods. In order to gain some perspective on the methods for estimating the second slope, we use data for thickness versus distance beyond the last isopach that are available for some of the larger eruptions in the Cascades. The thickness versus square root of area method is extended to thickness versus distance by developing an approximate relation between the two assuming elliptical isopachs with the source at one of the foci. Based on the comparisons made between the Carey et al. (1995) and Sulpizio (2005) methods, it is felt that the later method provides a better estimate of the second slope. For Mount St. Helens, the estimates of total volume using the Sulpizio (2005) method are generally smaller than those using the Carey et al. (1995) method. For the volume estimates of Carey et al. (1995), the volume of the May 18, 1980, eruption of Mount St. Helens is smaller than six of the eight previous eruptions. With the new volumes using the Sulpizio (2005) method, the 1980 eruption is smaller in volume than the upper end of the range for only three of the layers (Wn, Ye, and Yn) and is the same size as layer We. Thus the 1980 eruption becomes representative of the mid-range of volumes rather than being in the lower range.

  12. Hypersonic Experimental and Computational Capability, Improvement and Validation. Volume 2. (l’Hypersonique experimentale et de calcul - capacite, ameliorafion et validation)

    Science.gov (United States)

    1998-12-01

    between the tiles of the thermal protection system (TPS). The prime applicable correlations are due to Bertin etal. (1982). These correlations have...York, in 1987, refurbished, and recommissioned in 1989. Erdos et al. (1994) have recently described the GASL facility and its expanded operational...Charbonnier of VKI, M. Holden of Calspan, Hans Hournung of CALTECH, and J. Erdos of GASL is given for useful discussions and assistance in writing this

  13. Regional Sediment Management Strategies for the Vicinity of St. Augustine Inlet, St. Johns County, Florida

    Science.gov (United States)

    2016-07-01

    Ponte Vedra Beach and Vilano Beach, data indicate that it is best suited to beaches south of the inlet such as Anastasia Island and St. Augustine Beach...11 St. Johns County HSDR Feasibility Study: South Ponte Vedra Beach...feasibility study of potential additional segments of the overall St. Johns County SPP for nourishment, including South Ponte Vedra Beach and Vilano

  14. Mass and Thermodynamic Volume in Lifshitz Spacetimes

    CERN Document Server

    Brenna, Wilson G; Park, Miok

    2015-01-01

    We examine the concept of black hole thermodynamic volume and its consistency with thermodynamic mass in spacetimes that are not asymptotically flat but instead have anisotropic Lifshitz scaling symmetry. We find that the generalized Smarr relation in anti de Sitter space -- extended to include a pressure-volume term -- holds here as well, and that there exists a definition of thermodynamic mass and thermodynamic volume that satisfy both this relation and the $1^{st}$ law of thermodynamics. We compare the thermodynamic mass with other known quantities such as ADM, Brown-York and Hollands-Ishibashi-Marolf masses. We also conjecture methods for obtaining a thermodynamic mass where there is ambiguity due to the cosmological constant lengthscale depending on the horizon radius lengthscale.

  15. The St. George's Respiratory Questionnaire in Lymphangioleiomyomatosis

    Institute of Scientific and Technical Information of China (English)

    Kai-feng Xu; Lan Wang; Xin-lun Tian; Yao-song Gui; Min Peng; Bai-qiang Cai; Yuan-jue Zhu

    2010-01-01

    Objective To examine the correlation between the health-related quality of life measured by the St. George's Respiratory Questionnaire (SGRQ) and the commonly used physiological measures in lymphangi-oleiomyomatosis (LAM).Methods This study retrospectively analyzed the SGRQ scores and other measures (the Borg scale of breathlessness at rest, 6-minute walking distance, blood oxygen levels, and pulmonary function) of patients diagnosed and confirmed with LAM. Altogether 38 patients between June 2007 and November 2009 were included.Results The mean values of the SGRQ three components (symptoms, activity, and impacts) and total scores in the LAM patients were 46.95±28.90, 58.47±25.41,47.89±29.66, and 51. 11±26.35, respec-tively. The SGRQ total or component scores were correlated well with the Borg scale of breathlessness, 6-minute walking distance, partial pressure of oxygen in arterial blood, spirometry and diffusion capacity of lung. There were poor correlations between SGRQ score and residual volume or total lung capacity. In our preliminary observation, sirolimus improved the SGRQ total and three component scores and the Borg scale of breathlessness significantly after 101-200 days of treatment (n=6).Conclusions The SGRQ score in LAM is correlated well with physiological measures (Borg scale of breathlessness, 6-minute walking distance, blood oxygen levels, and pulmonary function tests). The SGRQ could therefore be recommended in baseline and follow-up evaluation of patients with LAM. Treatment with sirolimus, an inhibitor of mammalian target of rapamycin, may improve the quality of life and patient's per-ception of breathlessness in LAM.

  16. The role of the st313-td gene in virulence of Salmonella Typhimurium ST313.

    Directory of Open Access Journals (Sweden)

    Ana Herrero-Fresno

    Full Text Available Multidrug-resistant Salmonella enterica serovar Typhimurium ST313 has emerged in sub-Saharan Africa causing severe infections in humans. Therefore, it has been speculated that this specific sequence type, ST313, carries factors associated with increased pathogenicity. We assessed the role in virulence of a gene with a yet unknown function, st313-td, detected in ST313 through comparative genomics. Additionally, the structure of the genomic island ST313-GI, harbouring the gene was determined. The gene st313-td was cloned into wild type S. Typhimurium 4/74 (4/74-C as well as knocked out in S. Typhimurium ST313 02-03/002 (Δst313-td followed by complementation (02-03/002-C. Δst313-td was less virulent in mice following i.p. challenge than the wild type and this phenotype could be partly complemented in trans, indicating that st313-td plays a role during systemic infection. The gene st313-td was shown not to affect invasion of cultured epithelial cells, while the absence of the gene significantly affects uptake and intracellular survival within macrophages. The gene st313-td was proven to be strongly associated to invasiveness, harboured by 92.5% of S. Typhimurium blood isolates (n = 82 and 100% of S. Dublin strains (n = 50 analysed. On the contrary, S. Typhimurium isolates of animal and food origin (n = 82 did not carry st313-td. Six human, non-blood isolates of S. Typhimurium from Belarus, China and Nepal harboured the gene and belonged to sequence types ST398 and ST19. Our data showed a global presence of the st313-td gene and in other sequence types than ST313. The gene st313-td was shown to be expressed during logarithmic phase of growth in 14 selected Salmonella strains carrying the gene. This study reveals that st313-td plays a role in S. Typhimurium ST313 pathogenesis and adds another chapter to understanding of the virulence of S. Typhimurium and in particular of the emerging sequence type ST313.

  17. Vibrational spectroscopic and theoretical study of 3,5-dimethyl-1-thiocarboxamide pyrazole (L) and the complexes Co{sub 2}L{sub 2}Cl{sub 4}, Cu{sub 2}L{sub 2}Cl{sub 4} and Cu{sub 2}L{sub 2}Br{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Nemcsok, Denes [Institute of General and Analytical Chemistry, Budapest University of Technology and Economics, Szt. Gellert ter 4, H-1111 Budapest (Hungary); Kovacs, Attila [Hungarian Academy of Sciences, Budapest University of Technology and Economics, Research Group of Technical Analytical Chemistry, Szt. Gellert ter 4, H-1111 Budapest (Hungary)], E-mail: akovacs@mail.bme.hu; Szecsenyi, Katalin Meszaros [Department of Chemistry, Faculty of Sciences, University of Novi Sad, 21000 Novi Sad, Trg D. Obradovica 3 (Serbia and Montenegro); Leovac, Vukadin M. [Department of Chemistry, Faculty of Sciences, University of Novi Sad, 21000 Novi Sad, Trg D. Obradovica 3 (Serbia and Montenegro)

    2006-09-29

    In the present paper we report a joint experimental and theoretical study of 3,5-dimethyl-1-thiocarboxamide pyrazole (L) and its complexes Co{sub 2}L{sub 2}Cl{sub 4}, Cu{sub 2}L{sub 2}Cl{sub 4} and Cu{sub 2}L{sub 2}Br{sub 2}. DFT computations were used to model the structural and bonding properties of the title compounds as well as to derive a reliable force field for the normal coordinate analysis of L. The computations indicated the importance of hydrogen bonding interactions in stabilising the global minimum structures on the potential energy surfaces. In contrast to the S-bridged binuclear Cu{sub 2}L{sub 2}Br{sub 2} complex found in the crystal, our computations predicted the formation of (CuLBr){sub 2} dimers in the isolated state stabilized by very strong (53 kJ/mol) N-H...Br hydrogen bonding interactions. On the basis of FT-IR and FT-Raman experiments and the DFT-derived scaled quantum mechanical force field we carried out a complete normal coordinate analysis of L. The FT-IR spectra of the three complexes were interpreted using the present assignment of L, literature data and computed results.

  18. Measurement of the ZZ production cross section and search for anomalous couplings in 2l2l' final states in pp collisions at $\\sqrt{s}$=7 TeV

    CERN Document Server

    Chatrchyan, Serguei; Sirunyan, Albert M; Tumasyan, Armen; Adam, Wolfgang; Aguilo, Ernest; Bergauer, Thomas; Dragicevic, Marko; Erö, Janos; Fabjan, Christian; Friedl, Markus; Fruehwirth, Rudolf; Ghete, Vasile Mihai; Hammer, Josef; Hörmann, Natascha; Hrubec, Josef; Jeitler, Manfred; Kiesenhofer, Wolfgang; Knünz, Valentin; Krammer, Manfred; Krätschmer, Ilse; Liko, Dietrich; Mikulec, Ivan; Pernicka, Manfred; Rahbaran, Babak; Rohringer, Christine; Rohringer, Herbert; Schöfbeck, Robert; Strauss, Josef; Taurok, Anton; Waltenberger, Wolfgang; Walzel, Gerhard; Widl, Edmund; Wulz, Claudia-Elisabeth; Mossolov, Vladimir; Shumeiko, Nikolai; Suarez Gonzalez, Juan; Bansal, Monika; Bansal, Sunil; Cornelis, Tom; De Wolf, Eddi A; Janssen, Xavier; Luyckx, Sten; Mucibello, Luca; Ochesanu, Silvia; Roland, Benoit; Rougny, Romain; Selvaggi, Michele; Staykova, Zlatka; Van Haevermaet, Hans; Van Mechelen, Pierre; Van Remortel, Nick; Van Spilbeeck, Alex; Blekman, Freya; Blyweert, Stijn; D'Hondt, Jorgen; Gonzalez Suarez, Rebeca; Kalogeropoulos, Alexis; Maes, Michael; Olbrechts, Annik; Van Doninck, Walter; Van Mulders, Petra; Van Onsem, Gerrit Patrick; Villella, Ilaria; Clerbaux, Barbara; De Lentdecker, Gilles; Dero, Vincent; Gay, Arnaud; Hreus, Tomas; Léonard, Alexandre; Marage, Pierre Edouard; Mohammadi, Abdollah; Reis, Thomas; Thomas, Laurent; Vander Marcken, Gil; Vander Velde, Catherine; Vanlaer, Pascal; Wang, Jian; Adler, Volker; Beernaert, Kelly; Cimmino, Anna; Costantini, Silvia; Garcia, Guillaume; Grunewald, Martin; Klein, Benjamin; Lellouch, Jérémie; Marinov, Andrey; Mccartin, Joseph; Ocampo Rios, Alberto Andres; Ryckbosch, Dirk; Strobbe, Nadja; Thyssen, Filip; Tytgat, Michael; Walsh, Sinead; Yazgan, Efe; Zaganidis, Nicolas; Basegmez, Suzan; Bruno, Giacomo; Castello, Roberto; Ceard, Ludivine; Delaere, Christophe; Du Pree, Tristan; Favart, Denis; Forthomme, Laurent; Giammanco, Andrea; Hollar, Jonathan; Lemaitre, Vincent; Liao, Junhui; Militaru, Otilia; Nuttens, Claude; Pagano, Davide; Pin, Arnaud; Piotrzkowski, Krzysztof; Schul, Nicolas; Vizan Garcia, Jesus Manuel; Beliy, Nikita; Caebergs, Thierry; Daubie, Evelyne; Hammad, Gregory Habib; Alves, Gilvan; Correa Martins Junior, Marcos; Martins, Thiago; Pol, Maria Elena; Henrique Gomes E Souza, Moacyr; Aldá Júnior, Walter Luiz; Carvalho, Wagner; Custódio, Analu; Da Costa, Eliza Melo; De Jesus Damiao, Dilson; De Oliveira Martins, Carley; Fonseca De Souza, Sandro; Matos Figueiredo, Diego; Mundim, Luiz; Nogima, Helio; Prado Da Silva, Wanda Lucia; Santoro, Alberto; Soares Jorge, Luana; Sznajder, Andre; Vilela Pereira, Antonio; Souza Dos Anjos, Tiago; Bernardes, Cesar Augusto; De Almeida Dias, Flavia; Tomei, Thiago; De Moraes Gregores, Eduardo; Lagana, Caio; Da Cunha Marinho, Franciole; Mercadante, Pedro G; Novaes, Sergio F; Padula, Sandra; Genchev, Vladimir; Iaydjiev, Plamen; Piperov, Stefan; Rodozov, Mircho; Stoykova, Stefka; Sultanov, Georgi; Tcholakov, Vanio; Trayanov, Rumen; Vutova, Mariana; Dimitrov, Anton; Hadjiiska, Roumyana; Kozhuharov, Venelin; Litov, Leander; Pavlov, Borislav; Petkov, Peicho; Bian, Jian-Guo; Chen, Guo-Ming; Chen, He-Sheng; Jiang, Chun-Hua; Liang, Dong; Liang, Song; Meng, Xiangwei; Tao, Junquan; Wang, Jian; Wang, Xianyou; Wang, Zheng; Xiao, Hong; Xu, Ming; Zang, Jingjing; Zhang, Zhen; Asawatangtrakuldee, Chayanit; Ban, Yong; Guo, Yifei; Li, Wenbo; Liu, Shuai; Mao, Yajun; Qian, Si-Jin; Teng, Haiyun; Wang, Dayong; Zhang, Linlin; Zou, Wei; Avila, Carlos; Gomez, Juan Pablo; Gomez Moreno, Bernardo; Osorio Oliveros, Andres Felipe; Sanabria, Juan Carlos; Godinovic, Nikola; Lelas, Damir; Plestina, Roko; Polic, Dunja; Puljak, Ivica; Antunovic, Zeljko; Kovac, Marko; Brigljevic, Vuko; Duric, Senka; Kadija, Kreso; Luetic, Jelena; Morovic, Srecko; Attikis, Alexandros; Galanti, Mario; Mavromanolakis, Georgios; Mousa, Jehad; Nicolaou, Charalambos; Ptochos, Fotios; Razis, Panos A; Finger, Miroslav; Finger Jr, Michael; Assran, Yasser; Elgammal, Sherif; Ellithi Kamel, Ali; Mahmoud, Mohammed; Radi, Amr; Kadastik, Mario; Müntel, Mait; Raidal, Martti; Rebane, Liis; Tiko, Andres; Eerola, Paula; Fedi, Giacomo; Voutilainen, Mikko; Härkönen, Jaakko; Heikkinen, Mika Aatos; Karimäki, Veikko; Kinnunen, Ritva; Kortelainen, Matti J; Lampén, Tapio; Lassila-Perini, Kati; Lehti, Sami; Lindén, Tomas; Luukka, Panja-Riina; Mäenpää, Teppo; Peltola, Timo; Tuominen, Eija; Tuominiemi, Jorma; Tuovinen, Esa; Ungaro, Donatella; Wendland, Lauri; Banzuzi, Kukka; Karjalainen, Ahti; Korpela, Arja; Tuuva, Tuure; Besancon, Marc; Choudhury, Somnath; Dejardin, Marc; Denegri, Daniel; Fabbro, Bernard

    2013-01-01

    A measurement is presented of the ZZ production cross section in the ZZ to 2l 2l' decay mode with l = e, mu and l' = e, mu, tau in proton-proton collisions at $\\sqrt{s}$ = 7 TeV with the CMS experiment at the LHC. Results are based on data corresponding to an integrated luminosity of 5.0 inverse femtobarns. The measured cross section sigma(pp to ZZ) = 6.24 [+0.86/-0.80] (stat.) [+0.41/-0.32] (syst.) +/- 0.14 (lumi.) pb is consistent with the standard model predictions. The following limits on ZZZ and ZZ gamma anomalous trilinear gauge couplings are set at 95% confidence level: -0.011$\\lt$ f[4;Z] $\\lt$ 0.012, -0.012 $\\lt$ f[5;Z] $\\lt$ 0.012, -0.013 $\\lt$ f[4;gamma]<0.015, and -0.014 $\\lt$ f[5,gamma] $\\lt$ 0.014.

  19. Non ST-elevation acute coronary syndrome

    OpenAIRE

    Sarkees, Michael L; Bavry, Anthony A.

    2010-01-01

    Non ST-elevation acute coronary syndrome (NSTE-ACS, here defined as unstable angina and non ST-elevation MI) is characterised by episodes of chest pain at rest or with minimal exertion, which increase in frequency or severity, often with dynamic ECG changes.

  20. Firmaets Største Bedrift

    DEFF Research Database (Denmark)

    Hansen, Peer Henrik

    fortæller, hvordan de tidligere modstandsfolk Arne Sejr og Niels Frommelt få år efter befrielsen etablerede deres såkaldte Firma for med støtte fra ledende danske politikere, Forsvarets Efterretningstjeneste og CIA at organisere en hemmelig krig mod Sovjetunionens danske støtter. Meget tyder på, at både...

  1. 21st Century Skills Map: The Arts

    Science.gov (United States)

    Dean, Colleen; Ebert, Christie M. Lynch; McGreevy-Nichols, Susan; Quinn, Betsy; Sabol, F. Robert; Schmid, Dale; Shauck, R. Barry; Shuler, Scott C.

    2010-01-01

    This 21st Century Skills Map is the result of hundreds of hours of research, development and feedback from educators and business leaders across the nation. The Partnership for 21st Century Skills has issued this map for the core subject of the Arts.

  2. St. John's Wort (Hypericum Perforatum) and Pregnancy

    Science.gov (United States)

    ... best live chat Live Help Fact Sheets Share St. John’s Wort (Hypericum perforatum) Friday, 01 May 2015 In every pregnancy, ... risk. This sheet talks about whether exposure to St. John’s Wort may increase the risk for birth defects over ...

  3. Conversion Tables. Volume 3, Subject Headings-LC and Dewey. Second Edition.

    Science.gov (United States)

    Scott, Mona L.

    This volume contains tables that list Library of Congress subject headings with corresponding Library of Congress and Dewey Decimal classification numbers (i.e., call numbers). Materials referenced in the conversion tables are the 21st edition of the "Dewey Decimal Classification," the most current edition of the various volumes of the…

  4. NR-2L: a two-level predictor for identifying nuclear receptor subfamilies based on sequence-derived features.

    Directory of Open Access Journals (Sweden)

    Pu Wang

    Full Text Available Nuclear receptors (NRs are one of the most abundant classes of transcriptional regulators in animals. They regulate diverse functions, such as homeostasis, reproduction, development and metabolism. Therefore, NRs are a very important target for drug development. Nuclear receptors form a superfamily of phylogenetically related proteins and have been subdivided into different subfamilies due to their domain diversity. In this study, a two-level predictor, called NR-2L, was developed that can be used to identify a query protein as a nuclear receptor or not based on its sequence information alone; if it is, the prediction will be automatically continued to further identify it among the following seven subfamilies: (1 thyroid hormone like (NR1, (2 HNF4-like (NR2, (3 estrogen like, (4 nerve growth factor IB-like (NR4, (5 fushi tarazu-F1 like (NR5, (6 germ cell nuclear factor like (NR6, and (7 knirps like (NR0. The identification was made by the Fuzzy K nearest neighbor (FK-NN classifier based on the pseudo amino acid composition formed by incorporating various physicochemical and statistical features derived from the protein sequences, such as amino acid composition, dipeptide composition, complexity factor, and low-frequency Fourier spectrum components. As a demonstration, it was shown through some benchmark datasets derived from the NucleaRDB and UniProt with low redundancy that the overall success rates achieved by the jackknife test were about 93% and 89% in the first and second level, respectively. The high success rates indicate that the novel two-level predictor can be a useful vehicle for identifying NRs and their subfamilies. As a user-friendly web server, NR-2L is freely accessible at either http://icpr.jci.edu.cn/bioinfo/NR2L or http://www.jci-bioinfo.cn/NR2L. Each job submitted to NR-2L can contain up to 500 query protein sequences and be finished in less than 2 minutes. The less the number of query proteins is, the shorter the time will

  5. NR-2L: a two-level predictor for identifying nuclear receptor subfamilies based on sequence-derived features.

    Science.gov (United States)

    Wang, Pu; Xiao, Xuan; Chou, Kuo-Chen

    2011-01-01

    Nuclear receptors (NRs) are one of the most abundant classes of transcriptional regulators in animals. They regulate diverse functions, such as homeostasis, reproduction, development and metabolism. Therefore, NRs are a very important target for drug development. Nuclear receptors form a superfamily of phylogenetically related proteins and have been subdivided into different subfamilies due to their domain diversity. In this study, a two-level predictor, called NR-2L, was developed that can be used to identify a query protein as a nuclear receptor or not based on its sequence information alone; if it is, the prediction will be automatically continued to further identify it among the following seven subfamilies: (1) thyroid hormone like (NR1), (2) HNF4-like (NR2), (3) estrogen like, (4) nerve growth factor IB-like (NR4), (5) fushi tarazu-F1 like (NR5), (6) germ cell nuclear factor like (NR6), and (7) knirps like (NR0). The identification was made by the Fuzzy K nearest neighbor (FK-NN) classifier based on the pseudo amino acid composition formed by incorporating various physicochemical and statistical features derived from the protein sequences, such as amino acid composition, dipeptide composition, complexity factor, and low-frequency Fourier spectrum components. As a demonstration, it was shown through some benchmark datasets derived from the NucleaRDB and UniProt with low redundancy that the overall success rates achieved by the jackknife test were about 93% and 89% in the first and second level, respectively. The high success rates indicate that the novel two-level predictor can be a useful vehicle for identifying NRs and their subfamilies. As a user-friendly web server, NR-2L is freely accessible at either http://icpr.jci.edu.cn/bioinfo/NR2L or http://www.jci-bioinfo.cn/NR2L. Each job submitted to NR-2L can contain up to 500 query protein sequences and be finished in less than 2 minutes. The less the number of query proteins is, the shorter the time will

  6. Electroweak nature of new states via a di-photon resonance: S U (2 )L or just U (1 )Y?

    Science.gov (United States)

    No, Jose Miguel

    2016-08-01

    The existence of a 750 GeV di-photon spin-0 resonance S would imply the additional presence of new particles beyond the Standard Model, coupling directly to S and electromagnetically charged. For an S U (2 )L singlet S , we explore the possibility of probing the S U (2 )L and U (1 )Y quantum numbers of the new states at the LHC by measuring and constraining the W W , Z γ , and Z Z decays of S . We obtain robust prospects on the required LHC integrated luminosity to discover the new decay modes of S and discuss the implications of these measurements for probing the electroweak nature of the new states. We also discuss the impact of S mixing with the SM Higgs in such probes.

  7. Remote Synchronization Simulation of Onboard Crystal Oscillator for QZSS Using L1/L2/L5 Signals for Error Adjustment

    Directory of Open Access Journals (Sweden)

    Toshiaki Iwata

    2008-01-01

    Full Text Available A new error adjustment method for remote synchronization of the onboard crystal oscillator for the quasi-zenith satellite system (QZSS using three different frequency positioning signals (L1/L2/L5 is proposed. The error adjustment method that uses L1/L2 positioning signals was demonstrated in the past. In both methods, the frequency-dependent part and the frequency-independent part were considered separately, and the total time information delay was estimated. By adopting L1/L2/L5, synchronization was improved by approximately 15% compared with that using L1/L2 and approximately 10% compared with that using L1/L5 and a synchronization error of less than 0.77 nanosecond was realized.

  8. Apoptosis induced by(DIPP-L-Leu)2-L-Lys-OCH3 in K562 cells

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Apoptosis as a mechanism of deleting cells from tissues plays an important role in physiological and varieties of pathological situations, especially cancer conditions. In order to search for tumor cells apoptosis inducers, the inhibition effects on K562 cells of N-phosphoryl dipeptide methyl esters were studied by MTT assays, and (DIPP-L-Leu)2- L-Lys-OCH3 was the compound which had the best activity. From the studies of the typical apoptotic morphologic changes, DNA agarose gel electrophoresis, and flow cytometry analysis, it could be concluded that (DIPP-L-Leu)2- L-Lys-OCH3 could induce apoptosis of K562 cells in a dose-dependent manner, and the IC50 was 22.66 mol/L according to MTT assays.

  9. Galleria mellonella infection model demonstrates high lethality of ST69 and ST127 uropathogenic E. coli.

    Directory of Open Access Journals (Sweden)

    Majed F Alghoribi

    Full Text Available Galleria mellonella larvae are an alternative in vivo model for investigating bacterial pathogenicity. Here, we examined the pathogenicity of 71 isolates from five leading uropathogenic E. coli (UPEC lineages using G. mellonella larvae. Larvae were challenged with a range of inoculum doses to determine the 50% lethal dose (LD50 and for analysis of survival outcome using Kaplan-Meier plots. Virulence was correlated with carriage of a panel of 29 virulence factors (VF. Larvae inoculated with ST69 and ST127 isolates (10(4 colony-forming units/larvae showed significantly higher mortality rates than those infected with ST73, ST95 and ST131 isolates, killing 50% of the larvae within 24 hours. Interestingly, ST131 isolates were the least virulent. We observed that ST127 isolates are significantly associated with a higher VF-score than isolates of all other STs tested (P≤0.0001, including ST69 (P<0.02, but one ST127 isolate (strain EC18 was avirulent. Comparative genomic analyses with virulent ST127 strains revealed an IS1 mediated deletion in the O-antigen cluster in strain EC18, which is likely to explain the lack of virulence in the larvae infection model. Virulence in the larvae was not correlated with serotype or phylogenetic group. This study illustrates that G. mellonella are an excellent tool for investigation of the virulence of UPEC strains. The findings also support our suggestion that the incidence of ST127 strains should be monitored, as these isolates have not yet been widely reported, but they clearly have a pathogenic potential greater than that of more widely recognised clones, including ST73, ST95 or ST131.

  10. T cell antigen receptor expression by subsets of Ly-2-L3T4- (CD8-CD4-) thymocytes

    DEFF Research Database (Denmark)

    Wilson, A; Ewing, T; Owens, T

    1988-01-01

    The V beta 8-specific mAb F23.1 and KJ16 were used as fluorescent stains to test for TCR expression on the surface of subpopulations of early, CD4-CD8- (L3T4-Ly-2-) thymocytes from adult CBA mice. A surprisingly high proportion (27%) of Ly-2-L3T4- thymocytes were strongly F23.1 and KJ16 positive....

  11. Effect of polivalent bothropic antivenom on phospholipase A2, L-Amino acid oxidase and hyaluronidase from peruvian snake venom

    OpenAIRE

    Mendoza, Julio Cesar; Laboratorio de Biología Molecular, Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos. Lima, Perú. Biólogo.; Lazo, Fanny; Laboratorio de Biología Molecular, Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos. Lima, Perú. biólogo, magíster en Biotecnología.; Yarlequé, Liliana; Laboratorio de Biología Molecular, Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos. Lima, Perú. Obstetriz.; Ruiz, Nora Cecilia; Laboratorio de Biología Molecular, Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos. Lima, Perú. Biólogo.; Yarlequé, Armando; Laboratorio de Biología Molecular, Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos. Lima, Perú. Biólogo.; Pessah, Silvia; Centro Nacional de Productos Biológicos, Instituto Nacional de Salud. Lima, Perú. Médico.; Flores, Vicky; Centro Nacional de Productos Biológicos, Instituto Nacional de Salud. Lima, Perú. Químico farmaceútico.; Bonilla, César; Centro Nacional de Productos Biológicos, Instituto Nacional de Salud. Lima, Perú. Biólogo.

    2008-01-01

    Bothrops sp. snakes causing the largest number of cases of ophidism in Peru, their venom contain several enzymes related to poison spreading, miotoxic and platelet aggregation disturbances. Objectives. The inhibiting capacity of liquid polivalent bothropic antivenom from Instituto Nacional de Salud (INS) has been evaluated on phospholipase A2 (PLA2), L amino acid oxidase (LAO) and hyaluronidase activities using B. atrox, B. barnetti, B. brazili and B. pictus venoms. Material and methods. In e...

  12. Rapakivi Granite: An architectural emblem of St Petersburg and its utilisation in other world cities

    Science.gov (United States)

    Bulakh, Andrey; Gavrilenko, Vladimir; Panova, Helen

    2015-04-01

    . (In Russian). 3) Bulakh, A. G. Stone Town Guide, St Petersburg, 1-5. URL: [PDF] stone - GTK - Projects projects.gtk.fi/export/.../Bulakh_Stone_Guide 4) Paavo, H, Selonen, O, Luodes, H. The Wiborg Granite Batholith. The Main Production Area for Granite in Finland. Engineering Geology for Society and Territory - Volume 5. Springer. 2015. P. 259-262. 5) Bulakh, A. G. Ornamental Stone in the History of St Petersburg Architecture. Geological Society, London, 2015. SP407. Global Heritage Stone: Towards International Recognition of Building and Ornamental Stones.

  13. Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer

    Directory of Open Access Journals (Sweden)

    Haiyang Zhang

    2016-01-01

    Full Text Available ABSTRACT Gastric cancer is one of the most common malignancies worldwide; however, the molecular mechanism in tumorigenesis still needs exploration. BCL2L11 belongs to the BCL-2 family, and acts as a central regulator of the intrinsic apoptotic cascade and mediates cell apoptosis. Although miRNAs have been reported to be involved in each stage of cancer development, the role of miR-24 in GC has not been reported yet. In the present study, miR-24 was found to be up-regulated while the expression of BCL2L11 was inhibited in tumor tissues of GC. Studies from both in vitro and in vivo shown that miR-24 regulates BCL2L11 expression by directly binding with 3′UTR of mRNA, thus promoting cell growth, migration while inhibiting cell apoptosis. Therefore, miR-24 is a novel onco-miRNA that can be potential drug targets for future clinical use.

  14. Ulipristal Acetate Inhibits Progesterone Receptor Isoform A-Mediated Human Breast Cancer Proliferation and BCl2-L1 Expression.

    Directory of Open Access Journals (Sweden)

    Nathalie Esber

    Full Text Available The progesterone receptor (PR with its isoforms and ligands are involved in breast tumorigenesis and prognosis. We aimed at analyzing the respective contribution of PR isoforms, PRA and PRB, in breast cancer cell proliferation in a new estrogen-independent cell based-model, allowing independent PR isoforms analysis. We used the bi-inducible human breast cancer cell system MDA-iPRAB. We studied the effects and molecular mechanisms of action of progesterone (P4 and ulipristal acetate (UPA, a new selective progesterone receptor modulator, alone or in combination. P4 significantly stimulated MDA-iPRA expressing cells proliferation. This was associated with P4-stimulated expression of the anti-apoptotic factor BCL2-L1 and enhanced recruitment of PRA, SRC-1 and RNA Pol II onto the +58 kb PR binding motif of the BCL2-L1 gene. UPA decreased cell proliferation and repressed BCL2-L1 expression in the presence of PRA, correlating with PRA and SRC1 but not RNA Pol II recruitment. These results bring new information on the mechanism of action of PR ligands in controlling breast cancer cell proliferation through PRA in an estrogen independent model. Evaluation of PR isoforms ratio, as well as molecular signature studies based on PRA target genes could be proposed to facilitate personalized breast cancer therapy. In this context, UPA could be of interest in endocrine therapy. Further confirmation in the clinical setting is required.

  15. St2-80: a new FISH marker for St genome and genome analysis in Triticeae.

    Science.gov (United States)

    Wang, Long; Shi, Qinghua; Su, Handong; Wang, Yi; Sha, Lina; Fan, Xing; Kang, Houyang; Zhang, Haiqin; Zhou, Yonghong

    2017-07-01

    The St genome is one of the most fundamental genomes in Triticeae. Repetitive sequences are widely used to distinguish different genomes or species. The primary objectives of this study were to (i) screen a new sequence that could easily distinguish the chromosome of the St genome from those of other genomes by fluorescence in situ hybridization (FISH) and (ii) investigate the genome constitution of some species that remain uncertain and controversial. We used degenerated oligonucleotide primer PCR (Dop-PCR), Dot-blot, and FISH to screen for a new marker of the St genome and to test the efficiency of this marker in the detection of the St chromosome at different ploidy levels. Signals produced by a new FISH marker (denoted St2-80) were present on the entire arm of chromosomes of the St genome, except in the centromeric region. On the contrary, St2-80 signals were present in the terminal region of chromosomes of the E, H, P, and Y genomes. No signal was detected in the A and B genomes, and only weak signals were detected in the terminal region of chromosomes of the D genome. St2-80 signals were obvious and stable in chromosomes of different genomes, whether diploid or polyploid. Therefore, St2-80 is a potential and useful FISH marker that can be used to distinguish the St genome from those of other genomes in Triticeae.

  16. Crystal and molecular structure of 2,2'-(quinoxaline-2,3-diyl)dipyridinium dinitrate (H2 L)(NO3)2

    Science.gov (United States)

    Egorova, O. A.; Polyakova, I. N.; Sergienko, V. S.; Davydov, V. V.

    2016-07-01

    The crystal structure of 2,2'-(quinoxaline-2,3-diyl)dipyridinium dinitrate (H2 L)(NO3)2 is studied by X-ray diffraction ( T = 150 K, R1 = 0.0467). The H2 L 2+ cation is located on the twofold rotation axis and connected with two NO3 - anions by strong N-H···O hydrogen bonds. Planar quinoxaline fragments of cations form stacks with the interplanar spacing of 3.308 Å. The structure of the diprotonated H2 L 2+ cation is compared with those of the monoprotonated H2 L 2+ cation and neutral L molecule.

  17. International S&T Engagement Strategy

    Science.gov (United States)

    2014-07-01

    the DOD’s science and technology (S&T) and internationa l communities. Our offices, OASD(R&E) and OUSD(A T &L)/IC, have worked together to deve lop ...global engagement. Specifica lly, it is important to deve lop robust measures of success and maturity in priority S&T areas, and identify and address...Develop a baseline of relevant global S&T concepts, existing and emerging technologies, and capabilities. o Deve lop an understanding of the g loba l

  18. Environmental Inventory Report. East St. Louis and Vicinity, Cahokia Canal Drainage Area, Madison and St. Clair Counties, Illinois. Volume 3.

    Science.gov (United States)

    1981-05-01

    tacea and appear to be more sensitive indicators to environmental changes in water quality (Gannon and Stemberger , 1978). Diaphanosoma brachyurum...single long population pulses during the warmer months. Ac- cord;ng to Gannon and Stemberger (1978), B. longirostris has been utilized as an...Soc., 91: 82-84. Gannon, J.E. and Stemberger , R.S. 1978. Zooplankton (Especially Crustaceans and Rotifers) as Indicators of Water Quality. Trans

  19. Environmental Inventory Report. East St. Louis and Vicinity, Cahokia Canal Drainage Area, Madison and St. Clair Counties, Illinois. Volume 4.

    Science.gov (United States)

    1981-05-01

    coal in the present drainage area was found in 1807 by Trappist monks, who were then living at the Cahokia Mounds. They mined enough for their own...and Clark begin journey from Wood River 1807 Coal discovered in area by Trappist Monks 1809 Territory of Illinois established 1811 National Road begun

  20. Environmental Inventory Report. East St. Louis and Vicinity, Cahokia Canal Drainage Area, Madison and St. Clair Counties, Illinois. Volume 5.

    Science.gov (United States)

    1981-05-01

    Sheila Gibbons Elaine Burrus Mrs. Olive Potter Marie Hackett Mrs. Faye Cassens Ray Eberle Mrs. Jane Hornberger XX-A3 S Energy Conservation Committee...Board Keith E. Biggs Loren L. Madison Diane K. Skinner Paul L. Bennett Raymond L. Gandette, Jr. Donald C. Rea c XX-A8 emu * * - e- COLLINSVILLE Mayor

  1. Molecular biology of Homo sapiens: Abstracts of papers presented at the 51st Cold Spring Harbor symposium on quantitative biology

    Energy Technology Data Exchange (ETDEWEB)

    Watson, J.D.; Siniscalco, M.

    1986-01-01

    This volume contains abstracts of papers presented at the 51st Cold Springs Harbor Symposium on Quantitative Biology. The topic for this meeting was the ''Molecular Biology of Homo sapiens.'' Sessions were entitled Human Gene Map, Human Cancer Genes, Genetic Diagnosis, Human Evolution, Drugs Made Off Human Genes, Receptors, and Gene Therapy. (DT)

  2. 2,5-Dioxido-1,4-benzoquinonediimine (H2L2-), a hydrogen-bonding noninnocent bridging ligand related to aminated topaquinone: different oxidation state distributions in complexes [{(bpy)2Ru}2(mu-H2L)]n (n=0,+,2+,3+,4+) and [{(acac)2Ru}2(mu-H2L)]m (m=2-,-,0,+,2+).

    Science.gov (United States)

    Kar, Sanjib; Sarkar, Biprajit; Ghumaan, Sandeep; Janardanan, Deepa; van Slageren, Joris; Fiedler, Jan; Puranik, Vedavati G; Sunoj, Raghavan B; Kaim, Wolfgang; Lahiri, Goutam Kumar

    2005-08-19

    The symmetrically dinuclear title compounds were isolated as diamagnetic [(bpy)2Ru(mu-H2L)Ru(bpy)2](ClO4)2 (1-(ClO4)2) and as paramagnetic [(acac)2Ru(mu-H2L)Ru(acac)2] (2) complexes (bpy=2,2'-bipyridine; acac- = acetylacetonate = 2,4-pentanedionato; H2L = 2,5-dioxido-1,4-benzoquinonediimine). The crystal structure of 22 H2O reveals an intricate hydrogen-bonding network: Two symmetry-related molecules 2 are closely connected through two NH(H2L2-)O(acac-) interactions, while the oxygen atoms of H2L2- of two such pairs are bridged by an (H2O)8 cluster at half-occupancy. The cluster consists of cyclic (H2O)6 arrangements with the remaining two exo-H2O molecules connecting two opposite sides of the cyclo-(H2O)6 cluster, and oxido oxygen atoms forming hydrogen bonds with the molecules of 2. Weak antiferromagnetic coupling of the two ruthenium(III) centers in 2 was established by using SQUID magnetometry and EPR spectroscopy. Geometry optimization by means of DFT calculations was carried out for 1(2+) and 2 in their singlet and triplet ground states, respectively. The nature of low-energy electronic transitions was explored by using time-dependent DFT methods. Five redox states were reversibly accessible for each of the complexes; all odd-electron intermediates exhibit comproportionation constants K(c)>10(8). UV-visible-NIR spectroelectrochemistry and EPR spectroscopy of the electrogenerated paramagnetic intermediates were used to ascertain the oxidation-state distribution. In general, the complexes 1n+ prefer the ruthenium(II) configuration with electron transfer occurring largely at the bridging ligand (mu-H2Ln-), as evident from radical-type EPR spectra for 13+ and (+. Higher metal oxidation states (iii, iv) appear to be favored by the complexes 2m; intense long-wavelength absorption bands and RuIII-type EPR signals suggest mixed-valent dimetal configurations of the paramagnetic intermediates 2+ and 2-.

  3. Science diplomacy in the 21st century.

    Science.gov (United States)

    Fedoroff, Nina V

    2009-01-01

    Science diplomacy is the use of scientific collaborations among nations to address the common problems facing 21(st) century humanity and to build constructive international partnerships. There are many ways that scientists can contribute to this process.

  4. Hunting Plan: St. Vincent National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This plan provides guidelines for the administration of hunting activity and for the development, maintenance, and enforcement of regulations and guidelines on St....

  5. 2008 St. Johns County, FL Countywide Lidar

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Airborne terrestrial LiDAR was collected for St. Johns County, FL. System Parameters/Flight Plan. The LiDAR system acquisition parameters were developed based on a...

  6. Inventory Plan : St. Vincent National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The inventory procedures outlined in this plan represent a cost effective inventory of the wildlife populations on St. Vincent National Wildlife Refuge. Winter...

  7. Location - Managed Facility - St. Paul District (MVP)

    Data.gov (United States)

    Army Corps of Engineers, Department of the Army, Department of Defense — St. Paul District - US Army Corps of Engineers Managed Facility locations. District headquarters, Natural Resource, Recreation, Lock and Dam, and Regulatory offices...

  8. St. John Shallow Water Accuracy Assessment Transects

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Benthic habitat maps of the nearshore marine environment of St. John, U.S. Virgin Islands were created by visual interpretation of remotely sensed imagery. The...

  9. St. Vincent National Wildlife Refuge Historical Photographs

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document contains a series of photographs from St. Vincent Island. Photograph dates range from 1909 to 1969. Subjects include structures, vegetation, equipment,...

  10. St. Vincent National Wildlife Refuge : Plant Database

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This is the plant database for St. Vincent National Wildlife Refuge. The database is a compilation of published lists of plants for the refuge as well as site...

  11. A Monograph on St. Vincent's Game Preserve

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document describes the geography, history, climate, and wildlife of St. Vincent’s Game Preserve. Photographs, maps, articles, and letters are included.

  12. Natural History of St. Vincent Island, Florida

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — A study proposal aiming to ascertain, list and describe the woody flora and vertebrate fauna of St. Vincent Island, and to describe the terrestrial and fresh water...

  13. 2004 St. Johns County, Florida Lidar

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset is the bare earth lidar data for St. Johns County, Florida, acquired in early January and February of 2004. This data was collected to develop...

  14. ST elevation occurring during stress testing

    Directory of Open Access Journals (Sweden)

    Diana Malouf

    2016-04-01

    Full Text Available A case is presented of significant reversible ST elevation occurring during treadmill testing, and the coronary anatomy and subsequent course are described, indicating that ischemia is a potential cause of this electrocardiographic finding.

  15. Control Strategy Tool (CoST)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The EPA Control Strategy Tool (CoST) is a software tool for projecting potential future control scenarios, their effects on emissions and estimated costs. This tool...

  16. 2004 St. Johns County, Florida Lidar

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset is the bare earth lidar data for St. Johns County, Florida, acquired in early January and February of 2004. This data was collected to develop...

  17. St. Vincent Offers Special Archery & Primitive Hunts

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — St. Vincent National Wildlife Refuge's archery hunt is scheduled for November 28-30, 1984. White-tailed deer, turkeys, and hogs may be taken.

  18. Caribbean ST Croix Logbook Survey (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains catch (landed catch) and effort for fishing trips made by vessels fishing in St. Croix. The catch and effort data for the entire trip are...

  19. Caribbean ST Thomas trap Logbook Survey (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains catch (landed catch) and effort for fishing trips made by vessels fishing in St. Thomas. The catch and effort data for the entire trip are...

  20. Specification For ST-5 Li Ion Battery

    Science.gov (United States)

    Castell, Karen D.; Day, John H. (Technical Monitor)

    2000-01-01

    This Specification defines the general requirements for rechargeable Space Flight batteries intended for use in the ST-5 program. The battery chemistry chosen for this mission is lithium ion (Li-Ion).

  1. 1st International Conference on Calcined Clays for Sustainable Concrete

    CERN Document Server

    Favier, Aurélie

    2015-01-01

    This volume focuses on research and practical issues linked to Calcined Clays for Sustainable Concrete. The main subjects are geology of clays, hydration and performance of blended systems with calcined clays, alkali activated binders, economic and environmental impacts of the use of calcined clays in cement based materials. Topics addressed in this book include the influence of processing on reactivity of calcined clays, influence of clay mineralogy on reactivity, geology of clay deposits, Portland-calcined clay systems, hydration, durability, performance, Portland-calcined clay-limestone systems, hydration, durability, performance, calcined clay-alkali systems, life cycle analysis, economics and environmental impact of use of calcined clays in cement and concrete, and field applications. This book compiles the different contributions of the 1st International Conference on Calcined Clays for Sustainable Concrete, which took place in Lausanne, Switzerland, June, 23-25, 2015.The papers present the latest  res...

  2. 41st symposium of the European Space Agency

    CERN Document Server

    Macchetto, F Duccio

    2010-01-01

    The Hubble Space Telescope has facilitated major contributions to a wide range of topics in astronomy: The study of nearby planets The processes of star and planet formation The stellar and interstellar components of galaxies The discovery that most, if not all, galactic nuclei harbor a massive black hole that profoundly affects their evolution The realisation that the universe as a whole is undergoing acceleration as a result of a yet unknown form of "dark energy". This volume offers a broad perspective of the advancements made possible by the HST over its almost two decades of operation and emphasises their impact on European astronomical research. These proceedings of 41st symposium in the ESLAB series of the European Space Agency collect the oral and poster papers that were presented and discussed during the meeting.

  3. 21st International Conference on Domain Decomposition Methods

    CERN Document Server

    Gander, Martin; Halpern, Laurence; Pichot, Géraldine; Sassi, Taoufik; Widlund, Olof

    2014-01-01

    This volume contains a selection of papers presented at the 21st international conference on domain decomposition methods in science and engineering held in Rennes, France, June 25-29, 2012. Domain decomposition is an active and interdisciplinary research discipline, focusing on the development, analysis and implementation of numerical methods for massively parallel computers. Domain decomposition methods are among the most efficient solvers for large scale applications in science and engineering. They are based on a solid theoretical foundation and shown to be scalable for many important applications. Domain decomposition techniques can also naturally take into account multiscale phenomena. This book contains the most recent results in this important field of research, both mathematically and algorithmically and allows the reader to get an overview of this exciting branch of numerical analysis and scientific computing.

  4. A nosocomial outbreak of KPC-2-producing Klebsiella pneumoniae in a Chinese hospital: dissemination of ST11 and emergence of ST37, ST392 and ST395.

    Science.gov (United States)

    Yang, J; Ye, L; Guo, L; Zhao, Q; Chen, R; Luo, Y; Chen, Y; Tian, S; Zhao, J; Shen, D; Han, L

    2013-11-01

    In China, Klebsiella pneumoniae carbapenemase (KPC) -producing K. pneumoniae isolates have been identified. However, little is known about the spread and outbreak of KPC-producing enterobacterial pathogens. In this study, 48 non-duplicated KPC-producing isolates were analysed for genetic relatedness by pulsed-field gel electrophoresis (PFGE), antimicrobial susceptibility by E-test, and sequence type (ST) by multilocus sequence typing. S1-PFGE and Southern blot were used for plasmid profiling, and PCR and subsequent sequencing were performed to determine the effects of genetic background on the blaKPC gene. From December 2011 to June 2012, an outbreak of the KPC-2-producing K. pneumoniae was observed. The 48 isolates of K. pneumoniae are categorized into eight PFGE types (A1, A2, A3, A4, B, C, D and E). The predominant pathogens of the outbreak were strains with PFGE types A1, A2 and A3, which all belong to ST11. Furthermore, ST37, ST392 and ST395 KPC-2-producing K. pneumoniae isolates have also been sporadically identified. The blaKPC-2 -carrying plasmids vary in size from 30 to 220 kb. The genetic environments of the blaKPC-2 gene for most strains were consistent with the genetic structure of blaKPC-2 on the plasmid pKP048. In conclusion, the dissemination and outbreak of KPC-2-producing K. pneumoniae isolates in this study appeared to be clonal, and ST11 K. pneumoniae was the predominant clone attributed to the outbreak. This is the first study to report the emergence and spread of KPC-producing K. pneumoniae ST392 and ST395 worldwide. Our findings suggest that horizontal transfer of Tn3-based transposons might mediate the spread of blaKPC-2 gene between different K. pneumoniae clones in China.

  5. Marine biodiversity survey of St. Eustatius, 2015

    OpenAIRE

    Hoeksema, B. W.

    2016-01-01

    The Statia Marine Biodiversity Expedition (2015) was organized by Naturalis Biodiversity Center in Leiden (the national museum of natural history of the Netherlands) and ANEMOON Foundation (a Dutch organisation of citizen scientists) in Bennebroek, The Netherlands. This field survey served as a baseline study to explore the marine biota of St. Eustatius, a small island on the boundary between the eastern Caribbean and the West Atlantic. Since 2010, St. Eustatius is part of the Caribbean Nethe...

  6. 31st Winter Workshop in Nuclear Dynamics

    CERN Document Server

    2015-01-01

    The 31st edition of the Winter Workshop will be held January 25-31st, 2015 in the Keystone Resort, Colorado, USA. As with previous years, the workshop will bring together scientists from all fields of nuclear physics for engaging and friendly exchanges of ideas. Much emphasis will be on the recent LHC and RHIC heavy ion results, but advances in the ongoing and future programs at FAIR, FRIB, NICA and JLab will also be featured.

  7. St. Augustine in Twentieth-Century Music

    DEFF Research Database (Denmark)

    Petersen, Nils Holger

    2012-01-01

    A discussion - in a cultural historical perspective - of primarily two important twentieth-century musical works setting texts by St Augustine: Klaus Huber's Soliloquia Sancti Aurelii Augustini and Michael Tippett's The Vision of Saint Augustine.......A discussion - in a cultural historical perspective - of primarily two important twentieth-century musical works setting texts by St Augustine: Klaus Huber's Soliloquia Sancti Aurelii Augustini and Michael Tippett's The Vision of Saint Augustine....

  8. St Sava and the cloud-chasers

    Directory of Open Access Journals (Sweden)

    Loma Aleksandar

    2013-01-01

    Full Text Available A gloss in the Nomocanon of St Sava condemns folk superstitions related to magically provoking hailstorms and eclipses. St Sava’s miracle with the king of Hungary as described in his Vitae seems to go back to the same complex of popular beliefs. Its acceptance by the hagiography was probably due to the influence of the figure of prince magician as common to the Serbian and the Russian oral epics.

  9. Fossil fuels in the 21st century.

    Science.gov (United States)

    Lincoln, Stephen F

    2005-12-01

    An overview of the importance of fossil fuels in supplying the energy requirements of the 21st century, their future supply, and the impact of their use on global climate is presented. Current and potential alternative energy sources are considered. It is concluded that even with substantial increases in energy derived from other sources, fossil fuels will remain a major energy source for much of the 21st century and the sequestration of CO2 will be an increasingly important requirement.

  10. Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene

    Science.gov (United States)

    Himes, Blanca E.; Jiang, Xiaofeng; Hu, Ruoxi; Wu, Ann C.; Lasky-Su, Jessica A.; Klanderman, Barbara J.; Ziniti, John; Senter-Sylvia, Jody; Lima, John J.; Irvin, Charles G.; Peters, Stephen P.; Meyers, Deborah A.; Bleecker, Eugene R.; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Szefler, Stanley J.; Lemanske, Robert F.; Zeiger, Robert S.; Strunk, Robert C.; Martinez, Fernando D.; Hanrahan, John P.; Koppelman, Gerard H.; Postma, Dirkje S.; Nieuwenhuis, Maartje A. E.; Vonk, Judith M.; Panettieri, Reynold A.; Markezich, Amy; Israel, Elliot; Carey, Vincent J.; Tantisira, Kelan G.; Litonjua, Augusto A.; Lu, Quan; Weiss, Scott T.

    2012-01-01

    Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV1) before and after the administration of a short-acting β2-agonist, the most common rescue medications used for the treatment of asthma. BDR also serves as a test of β2-agonist efficacy. BDR is a complex trait that is partly under genetic control. A genome-wide association study (GWAS) of BDR, quantified as percent change in baseline FEV1 after administration of a β2-agonist, was performed with 1,644 non-Hispanic white asthmatic subjects from six drug clinical trials: CAMP, LOCCS, LODO, a medication trial conducted by Sepracor, CARE, and ACRN. Data for 469,884 single-nucleotide polymorphisms (SNPs) were used to measure the association of SNPs with BDR using a linear regression model, while adjusting for age, sex, and height. Replication of primary P-values was attempted in 501 white subjects from SARP and 550 white subjects from DAG. Experimental evidence supporting the top gene was obtained via siRNA knockdown and Western blotting analyses. The lowest overall combined P-value was 9.7E-07 for SNP rs295137, near the SPATS2L gene. Among subjects in the primary analysis, those with rs295137 TT genotype had a median BDR of 16.0 (IQR = [6.2, 32.4]), while those with CC or TC genotypes had a median BDR of 10.9 (IQR = [5.0, 22.2]). SPATS2L mRNA knockdown resulted in increased β2-adrenergic receptor levels. Our results suggest that SPATS2L may be an important regulator of β2-adrenergic receptor down-regulation and that there is promise in gaining a better understanding of the biological mechanisms of differential response to β2-agonists through GWAS. PMID:22792082

  11. Burkholderia cenocepacia BC2L-C is a super lectin with dual specificity and proinflammatory activity.

    Directory of Open Access Journals (Sweden)

    Ondřej Sulák

    2011-09-01

    Full Text Available Lectins and adhesins are involved in bacterial adhesion to host tissues and mucus during early steps of infection. We report the characterization of BC2L-C, a soluble lectin from the opportunistic pathogen Burkholderia cenocepacia, which has two distinct domains with unique specificities and biological activities. The N-terminal domain is a novel TNF-α-like fucose-binding lectin, while the C-terminal part is similar to a superfamily of calcium-dependent bacterial lectins. The C-terminal domain displays specificity for mannose and l-glycero-d-manno-heptose. BC2L-C is therefore a superlectin that binds independently to mannose/heptose glycoconjugates and fucosylated human histo-blood group epitopes. The apo form of the C-terminal domain crystallized as a dimer, and calcium and mannose could be docked in the binding site. The whole lectin is hexameric and the overall structure, determined by electron microscopy and small angle X-ray scattering, reveals a flexible arrangement of three mannose/heptose-specific dimers flanked by two fucose-specific TNF-α-like trimers. We propose that BC2L-C binds to the bacterial surface in a mannose/heptose-dependent manner via the C-terminal domain. The TNF-α-like domain triggers IL-8 production in cultured airway epithelial cells in a carbohydrate-independent manner, and is therefore proposed to play a role in the dysregulated proinflammatory response observed in B. cenocepacia lung infections. The unique architecture of this newly recognized superlectin correlates with multiple functions including bacterial cell cross-linking, adhesion to human epithelia, and stimulation of inflammation.

  12. Numerical simulation of heavy fermions in an SU(2)_L x SU(2)_R symmetric Yukawa model

    CERN Document Server

    Frick, C; Montvay, István; Münster, G; Plagge, M; Trappenberg, T; Wittig, H

    1993-01-01

    An exploratory numerical study of the influence of heavy fermion doublets on the mass of the Higgs boson is performed in the decoupling limit of a chiral $\\rm SU(2)_L \\otimes SU(2)_R$ symmetric Yukawa model with mirror fermions. The behaviour of fermion and boson masses is investigated at infinite bare quartic coupling on $4^3 \\cdot 8$, $6^3 \\cdot 12$ and $8^3 \\cdot 16$ lattices. A first estimate of the upper bound on the renormalized quartic coupling as a function of the renormalized Yukawa-coupling is given.

  13. Solving the U(2)L X U(2)R symmetric Nambu--Jona-Lasinio model in 1+1 dimensions

    CERN Document Server

    Thies, Michael

    2016-01-01

    A less well known variant of the Nambu--Jona-Lasinio model with Nc colors and U(2)L X U(2)R chiral symmetry is studied in 1+1 dimensions. Using semi-classical methods appropriate for the large Nc limit, we determine the vacuum manifold, the meson spectrum, massless and massive multi-fermion bound states and the phase diagram as a function of temperature, chemical potential and isospin chemical potential. An important tool to understand soliton dynamics is the generalization of the time-dependent Hartree-Fock approach to two flavors along the lines recently developed by Takahashi in the context of unconventional fermionic superfluids and superconductors.

  14. 雪铁龙C4 Cactus Airflow 2L概念车2L/100km

    Institute of Scientific and Technical Information of China (English)

    王晖

    2014-01-01

    面对城市拥挤、环保要求和经济压力,如今的消费者们将油耗作为购车时重要的考量指标。面对这个挑战,雪铁龙给出了令人震撼的答案—仅耗油2 L/100 km的雪铁龙全新C4 Cactus Airflow 2L概念车在2014巴黎车展上正式亮相。

  15. Ovarian volume throughout life

    DEFF Research Database (Denmark)

    Kelsey, Thomas W; Dodwell, Sarah K; Wilkinson, A Graham

    2013-01-01

    cancer. To date there is no normative model of ovarian volume throughout life. By searching the published literature for ovarian volume in healthy females, and using our own data from multiple sources (combined n=59,994) we have generated and robustly validated the first model of ovarian volume from...... to about 2.8 mL (95% CI 2.7-2.9 mL) at the menopause and smaller volumes thereafter. Our model allows us to generate normal values and ranges for ovarian volume throughout life. This is the first validated normative model of ovarian volume from conception to old age; it will be of use in the diagnosis...

  16. Die Thrombolysetherapie des ST-Streckenhebungsinfarktes 2002

    Directory of Open Access Journals (Sweden)

    Huber K

    2002-01-01

    Full Text Available Einleitung: Die medikamentöse Reperfusion thrombotisch verschlossener Koronargefäße mittels Fibrinolysetherapie ist ubiquitär rasch verfügbar und daher nach wie vor die wichtigste Behandlungsmöglichkeit des akuten ST-Streckenhebungsmyokardinfarktes (ST-Elevation Myocardial Infacrtion; STEMI. Die Fibrinolysetherapie wurde in den vergangenen Jahren an spezialisierten Herzkatheterzentren weniger häufig durchgeführt, da bei entsprechender Organsation ("Door-to-balloon"-Zeit von unter 60-90 Minuten; erfahrener Untersucher, "High-volume"-Center mit der Akutintervention (Akut-PCI die höchsten Wiedereröffnungsraten (TIMI-Grad 3-Fluß in über 90 % und die geringsten 30-Tages-Mortalitätsergebnisse (4,5 % in prospektiven Studien erzielt werden können. In Österreich werden derzeit unter 15 % aller für eine Reperfusionstherapie in Frage kommenden Infarktpatienten einer Akut-PCI zugeführt. Verbesserungsmöglichkeiten der Fibrinolysetherapie: Je kürzer die Zeit zwischen Infarkt- und Therapiebeginn ("time is muscle"! und je fibrinspezifischer (raschere und qualitativ bessere Wiedereröffnung des Infarktgefäßes das verwendete Fibrinolytikum ist (von Vorteil sind hier t-PA, Alteplase und seine Mutanten r-PA, Reteplase, und TNK-tPA, Tenecteplase, desto geringer ist die Mortalitätsrate in klinischen Studien. r-PA weist eine längerer Halbwertzeit (Doppelbolusgabe möglich, aber eine geringere Fibrinspezifität als t-PA auf. Die spezifischen Veränderungen im TNK-tpA-Molekül (3 Punktmutationen haben zu einer längeren Halbwertzeit (dadurch als Einzelbolus applizierbar, einer höheren Fibrinspezifität und einer stärkeren Resistenz gegenüber dem natürlichen Hemmstoff PAI-1 von TNK-tPA gegenüber der Muttersubstanz geführt. Klinische Studien: t-PA (front-loaded = Neuhaus-Schema war bis vor kurzem der "Goldstandard" der Fibrinolysetherpie und hat sich in der GUSTO-1-Studie als deutlich wirksamer verglichen mit Streptokinase herausgestellt. In

  17. Schlafen 3 Mediates the Differentiating Effects of Cdx2 in Rat IEC-Cdx2L1 Enterocytes.

    Science.gov (United States)

    Walsh, Mary F; Hermann, Rebecca; Lee, Jun Hee; Chaturvedi, Lakshmishankar; Basson, Marc D

    2015-01-01

    Mature, differentiated enterocytes are essential for normal gut function and critical to recovery from pathological conditions. Little is known about the factors that regulate intestinal epithelial cell differentiation in the adult intestine. The transcription factor, Cdx2, involved in enterocytic differentiation, remains expressed in the adult. Since we have implicated Slfn3 in differentiation in vivo and in vitro, we examined whether it also mediated differentiation in the IEC-Cdx2-L1 cell model of differentiation. IEC-Cdx2-L1 cells, permanently transfected with Cdx2 under the control of isopropyl-β-D-thiogalactoside (IPTG), were stimulated to differentiate by 16-day exposure to IPTG. Transcript levels of Cdx2, Slfn 3, and villin were determined by quantitative reverse transcriptase-polymerase chain reaction of mRNA isolated from IPTG-treated and control cells. Slfn3 expression was lowered with specific siRNA to investigate the role of Slfn3 in Cdx2-driven villin expression in IPTG-differentiated cells. Slfn3 and villin expression were significantly greater in IPTG-treated cells. Slfn3 siRNA lowered Slfn3 expression and abolished the IPTG-induced rise in villin expression (p IEC-6 cells that do not normally express Cdx2 can be differentiated by a variety of Slfn3-dependent mechanisms.

  18. The insecticide fipronil and its metabolite fipronil sulphone inhibit the rat α1β2γ2L GABAA receptor

    Science.gov (United States)

    Li, P; Akk, G

    2008-01-01

    Background and purpose: Fipronil is the active ingredient in a number of widely used insecticides. Human exposure to fipronil leads to symptoms (headache, nausea and seizures) typically associated with the antagonism of GABAA receptors in the brain. In this study, we have examined the modulation of the common brain GABAA receptor subtype by fipronil and its major metabolite, fipronil sulphone. Experimental approach: Whole-cell and single-channel recordings were made from HEK 293 cells transiently expressing rat α1β2γ2L GABAA receptors. Key results: The major effect of fipronil was to increase the rate of current decay in macroscopic recordings. In single-channel recordings, the presence of fipronil resulted in shorter cluster durations without affecting the intracluster open and closed time distributions or the single-channel conductance. The α1V256S mutation, previously shown alleviate channel inhibition by inhibitory steroids and several insecticides, had a relatively small effect on channel block by fipronil. The mode of action of fipronil sulphone was similar to that of its parent compound but the metabolite was less potent at inhibiting the α1β2γ2L receptor. Conclusions and implications: We conclude that exposure to fipronil induces accumulation of receptors in a novel, long-lived blocked state. This process proceeds in parallel with and independently of, channel desensitization. The lower potency of fipronil sulphone indicates that the conversion serves as a detoxifying process in mammalian brain. PMID:18660823

  19. Anticipated uncertainty budgets of PRARETIME and T2L2 techniques as applied to ExTRAS

    Science.gov (United States)

    Thomas, Claudine; Wolf, Peter; Uhrich, Pierre J. M.; Schaefer, W.; Nau, H.; Veillet, Christian

    1995-05-01

    The Experiment on Timing Ranging and Atmospheric Soundings, ExTRAS, was conceived jointly by the European Space Agency, ESA, and the Russian Space Agency, RSA. It is also designated the 'Hydrogen-maser in Space/Meteor-3M project'. The launch of the satellite is scheduled for early 1997. The package, to be flown on board a Russian meteorological satellite includes ultra-stable frequency and time sources, namely two active and auto-tuned hydrogen masers. Communication between the on-board hydrogen masers and the ground station clocks is effected by means of a microwave link using the modified version for time transfer of the Precise Range And Range-rate Equipment, PRARETIME, technique, and an optical link which uses the Time Transfer by Laser Link, T2L2, method. Both the PRARETIME and T2L2 techniques operate in a two-directional mode, which makes it possible to carry out accurate transmissions without precise knowledge of the satellite and station positions. Due to the exceptional quality of the on-board clocks and to the high performance of the communication techniques with the satellite, satellite clock monitoring and ground clocks synchronization are anticipated to be performed with uncertainties below 0.5 ns (1 sigma). Uncertainty budgets and related comments are presented.

  20. St. James marine terminal facility description

    Energy Technology Data Exchange (ETDEWEB)

    1993-10-01

    The US Department of Energy (DOE) currently owns and operates a marine terminal on the west bank of the Mississippi River at St. James, Louisiana. The St. James facility was constructed by the Department to provide marine services associated with the fill and drawdown of the Strategic Petroleum Reserve (SPR) crude oil storage facilities located at Bayou Choctaw and Weeks Island, Louisiana. Although strategic to the mission of the SPR in the event of a national emergency, the St. James terminal is situated such that it has a high potential to also serve the commercial industry`s needs for crude oil terminalling and storage. The St. James terminal is located approximately 45 miles west of New Orleans and 30 miles southeast of Baton Rouge, and approximately 160 miles upstream from the mouth of the Mississippi River. Construction of the St. James terminal was initiated in 1978 and was completed in 1980. Since then, the terminal has received and transferred over 125 million barrels of crude oil to the SPR sites for storage. For crude oil distribution, the St. James terminal was connected to the neighboring LOCAP terminal by a 0.1 mile 36-inch pipeline in 1981 and to the Capline terminal by a 0.5 mile 30-inch pipeline in 1988. The terminal also has a 30-inch pipeline connection to the Koch oil terminal which was used for initial fill purposes; however, this pipeline has been disconnected and is currently inactive. A complete description of the St. James terminal facilities, operational capabilities, operational certifications, and future Government requirements are presented in Sections 2, 3, 4, and 5 respectively.

  1. Mean nuclear volume

    DEFF Research Database (Denmark)

    Mogensen, O.; Sørensen, Flemming Brandt; Bichel, P.

    1999-01-01

    We evaluated the following nine parameters with respect to their prognostic value in females with endometrial cancer: four stereologic parameters [mean nuclear volume (MNV), nuclear volume fraction, nuclear index and mitotic index], the immunohistochemical expression of cancer antigen (CA125...

  2. Pax-8基因敲除小鼠心脏中Bcl2l14基因表达上调%Up-regulation of Bcl2l14 gene in myocardium of Pax-8 gene knockout mouse

    Institute of Scientific and Technical Information of China (English)

    高瞻; 来丹丹; 黄晓燕; 褚茂平; 施翔翔; 张怀勤; 杨德业

    2010-01-01

    目的:寻找先天性心脏病相关基因-转录因子Pax-8的下游基因.方法:分别提取Pax-8基因敲除小鼠纯合子(Pax-8 KO~(-/-))和杂合子(Pax-8 KO~(+/-))的心脏总RNA,利用含31 802个小鼠基因的基因芯片检测两组小鼠基因表达水平,找出差异表达的基因,并经半定量RT-PCR和荧光实时定量PCR技术初步筛选出转录因子Pax-8的下游基因.结果:基因芯片检测发现,Pax-8 KO~(-/-) 组与Pax-8 KO~(+/-) 相比有25个基因表达下调,另有17个基因表达上调,差异基因涉及细胞周期及信号转导的调节因子,直接参与代谢的酶,以及核转录因子等.用半定量RT-PCR验证发现:Bcl2-like 14(Bcl2l14)基因在Pax-8 KO~(-/-) 组上调.定量RT-PCR亦证实在Pax-8 KO~(-/-)组Bcl2l14基因的表达水平较Pax-8 KO~(+/-) 组及Pax-8 KO~(+/+)(野生型)组分别上调2.07倍和2.23倍(P<0.01).结论:Bcl2l14基因为转录因子Pax-8的下游基因,可能在先天性心脏病室间隔缺损的发病机制中发挥重要作用.

  3. Epidemiologic characteristics associated with ST23 clones compared to ST1 and ST47 clones of Legionnaires disease cases in France

    Directory of Open Access Journals (Sweden)

    P. Cassier

    2015-01-01

    Full Text Available In France, approximately 1200 cases of Legionnaires disease (LD are reported annually, and isolates are available for approximately 20% of cases identified since 2000. All Legionella pneumophila serogroup 1 (sg1 isolates are characterized by sequence-based typing at the National Reference Centre. LD cases caused by L. pneumophila sg1 reported from 2008 through 2012 were considered for the study. Our study objective was to describe cases according to their sequence type (ST. We also constructed multivariable modified Poisson regression models to estimate the incidence rate ratio (IRR and to identify characteristics potentially associated with ST23 clones compared to ST1 and ST47 clones. We studied 1192 patients infected by ST1 (n = 109, ST23 (n = 236, ST47 (n = 123 or other STs (n = 724. The geographic distribution of the ST23 cases across the country was significantly different compared to other ST groups. This genotype was significantly associated with the absence of corticosteroid therapy compared to ST1 (IRR = 0.56; p 0.016. Concerning exposure, the ST23 genotype was significantly less associated with hospital-acquired infections compared to ST1 (IRR = 0.32; p 0.001, but it was more associated with infections acquired in hospitals and elderly settings compared with ST47. Finally, the ST23 genotype was less frequently associated with travel than other STs. Despite the large number of cases of ST23 infection, we did not identify any characteristics specific to this ST. However, we identified independent associations between ST1 and nosocomial transmission and steroid therapy. These findings should encourage further exploration, especially in terms of environmental diffusion, strain virulence and host factors.

  4. 78 FR 23489 - Safety Zone; V.I. Carnival Finale, St. Thomas Harbor; St. Thomas, U.S.V.I.

    Science.gov (United States)

    2013-04-19

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; V.I. Carnival Finale, St. Thomas Harbor; St. Thomas, U.S.V.I. AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a safety zone on the waters of St. Thomas Harbor in St. Thomas, U.S. Virgin Islands during the...

  5. Combustion characteristics of stratified mixture. 1st Report. Measurement of mixture distribution in a constant-volume combustion chamber using laser-induced NO2 fluorescence; Sojo kongoki no nensho tokusei ni kansuru kenkyu. 1. Laser reiki NO2 keikoho ni yoru teiyo nenshokinai kongoki bunpu no keisoku

    Energy Technology Data Exchange (ETDEWEB)

    Fujimoto, M.; Nishida, K.; Hiroyasu, H. [Hiroshima University, Hiroshima (Japan). Faculty of Engineering; Tabata, M. [Mazda Motor Corp., Hiroshima (Japan)

    1996-06-25

    Laser-induced fluorescence from nitrogen dioxide (NO2) as gas fuel tracer was applied to determine mixture stratification in a pancake-type constant-volume combustion chamber using propane and hydrogen fuels. The second-harmonic output of a pulsed Nd: YAG laser was used as a light source for fluorescence excitation. The fluorescence images were corrected by a gated image-intensified CCD camera. The quantitative analysis of fuel concentration was made possible by the application of linearity between fluorescence intensity and NO2 concentration at a low trace level. The stratified mixture (center-rich or center-lean) was concentrically formed in the central region of the chamber by a jet flow from a tangentially oriented port. The concentration difference in the radial direction of the chamber decreased with time from the start of injection. The rate of decrease was faster for hydrogen than for propane. After 300 ms from start of injection, however, the time histories of the concentration difference were nearly constant for both fuels regardless of overall concentration. 10 refs., 16 figs., 1 tab.

  6. The marine Algal Vegetation of St. Martin, St. Eustatius and Saba (Netherlands Antilles)

    NARCIS (Netherlands)

    Vroman, M.

    1968-01-01

    Along the coast of St. Martin, St. Eustatius and Saba the rocks above sea-level often show a number of differently coloured zones. This is clearly visible when the coast over a larger distance is formed by one type of rock, as for instance on Saba. In many places a light-coloured belt is seen above

  7. The marine Algal Vegetation of St. Martin, St. Eustatius and Saba (Netherlands Antilles)

    NARCIS (Netherlands)

    Vroman, M.

    1968-01-01

    Along the coast of St. Martin, St. Eustatius and Saba the rocks above sea-level often show a number of differently coloured zones. This is clearly visible when the coast over a larger distance is formed by one type of rock, as for instance on Saba. In many places a light-coloured belt is seen above

  8. St. Thomas and St. John, U.S. Virgin Islands Coastal Digital Elevation Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 1/3 arc-second St. Thomas and St. John, U.S. Virgin Islands Coastal Digital Elevation Model will be used to support NOAA's tsunami forecast system and for...

  9. The Role of the st313-td Gene in Virulence of Salmonella Typhimurium ST313

    DEFF Research Database (Denmark)

    Herrero-Fresno, Ana; Wallrodt, Inke; Leekitcharoenphon, Pimlapas

    2014-01-01

    Multidrug-resistant Salmonella enterica serovar Typhimurium ST313 has emerged in sub-Saharan Africa causing severe infections in humans. Therefore, it has been speculated that this specific sequence type, ST313, carries factors associated with increased pathogenicity. We assessed the role in viru...

  10. Components of the interleukin-33/ST2 system are differentially expressed and regulated in human cardiac cells and in cells of the cardiac vasculature.

    Science.gov (United States)

    Demyanets, Svitlana; Kaun, Christoph; Pentz, Richard; Krychtiuk, Konstantin A; Rauscher, Sabine; Pfaffenberger, Stefan; Zuckermann, Andreas; Aliabadi, Arezu; Gröger, Marion; Maurer, Gerald; Huber, Kurt; Wojta, Johann

    2013-07-01

    Interleukin-33 (IL-33) is a recently described member of the IL-1 family of cytokines, which was identified as a ligand for the ST2 receptor. Components of the IL-33/ST2 system were shown to be expressed in normal and pressure overloaded human myocardium, and soluble ST2 (sST2) has emerged as a prognostic biomarker in myocardial infarction and heart failure. However, expression and regulation of IL-33 in human adult cardiac myocytes and fibroblasts was not tested before. In this study we found that primary human adult cardiac fibroblasts (HACF) and human adult cardiac myocytes (HACM) constitutively express nuclear IL-33 that is released during cell necrosis. Tumor necrosis factor (TNF)-α, interferon (IFN)-γ and IL-1β significantly increased both IL-33 protein and IL-33 mRNA expression in HACF and HACM as well as in human coronary artery smooth muscle cells (HCASMC). The nuclear factor-κB (NF-κB) inhibitor dimethylfumarate inhibited TNF-α- and IL-1β-induced IL-33 production as well as nuclear translocation of p50 and p65 NF-κB subunits in these cells. Mitogen-activated protein/extracellular signal-regulated kinase inhibitor U0126 abrogated TNF-α-, IFN-γ-, and IL-1β-induced and Janus-activated kinase inhibitor I reduced IFN-γ-induced IL-33 production. We detected IL-33 mRNA in human myocardial tissue from patients undergoing heart transplantation (n=27) where IL-33 mRNA levels statistically significant correlated with IFN-γ (r=0.591, p=0.001) and TNF-α (r=0.408, p=0.035) mRNA expression. Endothelial cells in human heart expressed IL-33 as well as ST2 protein. We also reveal that human cardiac and vascular cells have different distribution patterns of ST2 isoforms (sST2 and transmembrane ST2L) mRNA expression and produce different amounts of sST2 protein. Both human macrovascular (aortic and coronary artery) and heart microvascular endothelial cells express specific mRNA for both ST2 isoforms (ST2L and sST2) and are a source for sST2 protein, whereas

  11. Stückelberg formulation of holography

    Science.gov (United States)

    Dvali, Gia; Gomez, Cesar; Wintergerst, Nico

    2016-10-01

    We suggest that holography can be formulated in terms of the information capacity of the Stückelberg degrees of freedom that maintain gauge invariance of the theory in the presence of an information boundary. These Stückelbergs act as qubits that account for a certain fraction of quantum information. Their information capacity is measured by the ratio of the inverse Stückelberg energy gap to the size of the system. Systems with the smallest gap are maximally holographic. For massless gauge systems this information measure is universally equal to the inverse coupling evaluated at the systems' length scale. In this language it becomes very transparent why the Stückelberg information capacity of black holes saturates the Bekenstein bound and accounts for the entire information of the system. The physical reason is that the strength of quantum interaction is bounded from below by the gravitational coupling, which scales as area. Observing the striking similarity between the scalings of the energy gap of the boundary Stückelberg modes and the Bogoliubov modes of critical many-body systems, we establish a connection between holography and quantum criticality through the correspondence between these modes.

  12. 接受直接经皮冠状动脉介入治疗的ST段抬高型急性心肌梗死患者血小板体积的变化及与冠状动脉影像的关系%Platelet volume and its association with coronary angiograms in patients with ST-segment elevation acute myocardial infarction underwent primary percutaneous coronary intervention

    Institute of Scientific and Technical Information of China (English)

    许文亮; 王旭; 邵一兵; 惠波; 武越; 要英杰; 张纯全

    2012-01-01

    Objective To assess the platelet volume in patients with ST-segment elevation acute myocardial infarction ( STEMI) underwent primary percutaneous coronary intervention ( PPCI) and its association with coronary angiograms flow. Methods Total 163 patients with STEMI who underwent PPCI were enrolled. Mean platelet volume ( MPV) and platelet large cell ratio (P-LCR) and other biochemical parameters were measured on admission. The TIMI flow for the infarct-related artery (IRA) were evaluated before and after PPCI, and the IRA's corrected Thrombolysis In Myocardial Infarction frame count (CTFC) were also calculated. One hundred and seven in-hospital patients with stable angina pectoris were taken as control. Results MPV and P-LCR were increased significantly in STEMI patients compared to patients with stable angina pectoris [(10.30 ±0. 82) fl vs. (9. 89 ± 0. 98) fl,t = 3. 656,P = 0. 000; (27.24 ±6.43)% vs. (24. 51 ±5. 88)% ,t =3. 524,P =0. 000]. Patients with multiple coronary lesions showed much higher MPV and P-LCR than patients with single coronary lesions [ (10. 40 ± 0. 85) fl vs. (10. 04 ± 0. 69) fl, t =-2.558, P=0. 011; (27.96 ±6.64)% vs. (25. 40 ±5. 52)% ,t = - 2. 319,P = 0. 022]. Compared to those with left circumflex artery as IRA, patients with anterior descending coronary artery as IRA had markedly increased MPV and P-LCR [ (10. 42 ± 0. 86) fl vs. (9. 98 ± 0. 62) fl, P < 0. 05; (28. 07 ± 6. 63) % vs. (24. 48 ± 4. 76) % , P < 0. 05 ]. If the IRA' s coronary flow was TIMI grade 1 to 3 before PPCI, it was defined as spontaneous reperfusion. Patients without spontaneous reperfusion had markedly increased MPV and P-LCR than those with spontaneous reperfusion [ ( 10. 39 ± 0. 84) fl vs. ( 10. 04 ± 0. 69 ) fl, t = - 2. 460, P = 0.015; (27.83 ±6.61)% vs. (25. 64 ± 5. 70)% ,t = - 2. 082,P = 0. 040]. After PPCI, patients whose IRAs TIMI flow was less than grade 3 had significantly elevated MPV and P-LCR than patient with TIMI flow grade 3 [ (10. 68 ± 1

  13. Draft Genome Sequences of Staphylococcus aureus AMRF1 (ST22) and AMRF2 (ST672), Ocular Methicillin-Resistant Isolates

    KAUST Repository

    Velusamy, Nithya

    2014-03-20

    Sequence type 22 (ST22) and ST672 are the two major emerging clones of community-acquired methicillin-resistant Staphylococcus aureus in India. ST672 strains were found to cause severe ocular infections. We report the draft genome sequences of two emerging strains of methicillin-resistant S. aureus, AMRF1 (ST22) and AMRF2 (ST672), isolated from patients with ocular infections.

  14. Analyse of Maintenance Cost in ST

    CERN Document Server

    Jenssen, B W

    2001-01-01

    An analyse has been carried out in ST concerning the total costs for the division. Even though the target was the maintenance costs in ST, the global budget over has been analysed. This has been done since there is close relation between investments & consolidation and the required level for maintenance. The purpose of the analyse was to focus on maintenance cost in ST as a ratio of total maintenance costs over the replacement value of the equipment, and to make some comparisons with other industries and laboratories. Families of equipment have been defined and their corresponding ratios calculated. This first approach gives us some "quantitative" measurements. This analyse should be combined with performance indicators (more "qualitative" measurements) that are telling us how well we are performing. This will help us in defending our budget, make better priorities, and we will satisfy the requirements from our external auditors.

  15. Materials for the 21st century

    CERN Document Server

    Segal, David

    2017-01-01

    The book is a general text that shows how materials can contribute to solving problems facing nations in the 21st century. It is illustrated with diverse applications and highlights the potential of existing materials for everyday life, healthcare and the economies of nations. There are 13 chapters and a glossary of 500 materials with their descriptions, historical development, their use or potential use and a range of references. Specific areas include synthetic polymers (e.g. nylon), natural polymers (e.g. proteins, cellulose) and the role of materials in the development of digital computers and in healthcare. Solid-state lighting, energy supplies in the 21st century, disruptive technologies and intellectual property, in particular patents, are discussed. The book concludes by asking how the 21st century will be characterised. Will it be the Silicon Age, Genomic Age or New Polymer Age, as examples?

  16. Detection of methicillin-resistant Staphylococcus pseudintermedius ST169 and novel ST354 SCCmec II-III isolates related to the worldwide ST71 clone.

    Science.gov (United States)

    Ishihara, K; Koizumi, A; Saito, M; Muramatsu, Y; Tamura, Y

    2016-01-01

    The recent appearance of methicillin-resistant Staphylococcus pseudintermedius (MRSP) is a concern for both veterinary and human healthcare. MRSP clonal lineages with sequence type (ST) 71-spa t02-staphylococcal cassette chromosome mec (SCCmec) II-III and ST68-spa t06-SCCmec V have spread throughout Europe and North America, respectively. The current study compared the molecular characteristics of 43 MRSP isolates from dogs in Japan with those of MRSP from previous reports using multilocus sequence typing based on seven housekeeping genes, SCCmec typing, and detection of antimicrobial resistance genes. Three related clonal lineages, ST71, ST169, and the newly registered ST354, were observed in SCCmec II-III isolates from Japan, despite MRSP SCCmec II-III isolates being thought to belong to a single clonal lineage. The majority of SCCmec II-III isolates belonging to ST169 (9/11) and ST354 (3/3), but not ST71 (0/11), harboured tetM. Four STs were observed for the SCCmec V isolates; however, neither ST68 nor related STs were found in the Japanese MRSP isolates. In conclusion, MRSP SCCmec II-III isolates from Japan belonged to ST71 and related STs (ST169 and ST354). A variety of MRSP SCCmec V clones, including some novel clones, were identified.

  17. Anticancer Potencies of Pt(II) - and Pd(II)-linked M2L4 Coordination Capsules with Improved Selectivity.

    Science.gov (United States)

    Ahmedova, Anife; Momekova, Denitsa; Yamashina, Masahiro; Shestakova, Pavletta; Momekov, Georgi; Akita, Munetaka; Yoshizawa, Michito

    2016-02-18

    Pt(II) - and Pd(II)-linked M2 L4 coordination capsules, providing a confined cavity encircled by polyaromatic frameworks, exhibit anticancer activities superior to cisplatin against two types of leukemic cells (HL-60 and SKW-3) and pronounced toxicity against cisplatin-resistant cells (HL-60/CDDP). Notably, the cytotoxic selectivities of the Pt(II) and Pd(II) capsules toward cancerous cells are up to 5.3-fold higher than that of cisplatin, as estimated through the non-malignant/malignant-cells toxicity ratio employing normal kidney cells (HEK-293). In addition, the anticancer activity of the coordination capsules can be easily altered upon encapsulation of organic guest molecules.

  18. The Chromatin Remodelling Enzymes SNF2H and SNF2L Position Nucleosomes adjacent to CTCF and Other Transcription Factors.

    Directory of Open Access Journals (Sweden)

    Nicola Wiechens

    2016-03-01

    Full Text Available Within the genomes of metazoans, nucleosomes are highly organised adjacent to the binding sites for a subset of transcription factors. Here we have sought to investigate which chromatin remodelling enzymes are responsible for this. We find that the ATP-dependent chromatin remodelling enzyme SNF2H plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding. At many other factor binding sites SNF2H and the related enzyme SNF2L contribute to nucleosome organisation. The action of SNF2H at CTCF sites is functionally important as depletion of CTCF or SNF2H affects transcription of a common group of genes. This suggests that chromatin remodelling ATPase's most closely related to the Drosophila ISWI protein contribute to the function of many human gene regulatory elements.

  19. The Chromatin Remodelling Enzymes SNF2H and SNF2L Position Nucleosomes adjacent to CTCF and Other Transcription Factors.

    Science.gov (United States)

    Wiechens, Nicola; Singh, Vijender; Gkikopoulos, Triantaffyllos; Schofield, Pieta; Rocha, Sonia; Owen-Hughes, Tom

    2016-03-01

    Within the genomes of metazoans, nucleosomes are highly organised adjacent to the binding sites for a subset of transcription factors. Here we have sought to investigate which chromatin remodelling enzymes are responsible for this. We find that the ATP-dependent chromatin remodelling enzyme SNF2H plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding. At many other factor binding sites SNF2H and the related enzyme SNF2L contribute to nucleosome organisation. The action of SNF2H at CTCF sites is functionally important as depletion of CTCF or SNF2H affects transcription of a common group of genes. This suggests that chromatin remodelling ATPase's most closely related to the Drosophila ISWI protein contribute to the function of many human gene regulatory elements.

  20. Time Transfer by Laser Link - the T2L2 Experiment on JASON-2 and Further Experiments

    Science.gov (United States)

    Samain, Étienne; Weick, Jonathan; Vrancken, Patrick; Para, Franck; Albanese, Dominique; Paris, Jocelyn; Torre, Jean-Marie; Zhao, Cheng; Guillemot, Philippe; Petitbon, Isabelle

    The new generation of optical time transfer will allow the synchronization of remote ultra stable clocks and the determination of their performances over intercontinental distances. The principle of T2L2 (Time Transfer by Laser Link) is based on the techniques of satellite laser ranging coupled with time-frequency metrology. It consists of synchronizing ground and space clocks using short laser pulses travelling between ground clocks and satellite equipment. The instrument will be integrated on the ocean altimetry satellite Jason-2 that is scheduled for launch in 2008. The experiment should enhance the performance of time transfer by one or two magnitudes compared to existing microwave techniques such as GPS and Two-Way Satellite Time and Frequency Transfer (TWSTFT).

  1. The 21st Century as Whose Century?

    Directory of Open Access Journals (Sweden)

    David Scott

    2015-08-01

    Full Text Available Macro-analysis and East-West encounter are shown through consideration of objective yet subjective constructed concepts for the international system and international economy in the 21st century. Three paradigms are considered, namely the 21st century as the ‘Pacific Century’, as ‘China’s Century’ and as the ‘Asian Century’. Overlaps are shown between these three paradigms, as also developments in time, and gradually shift in geographical location. The ‘Pacific Century’, and its associated Rimspeak, was the paradigm emerging in the late 1970s, knitting together America’s West Coast and the Japanese economy. By the late 1980s this was already shifting to talk of the 21st century likely to be an ‘Asian Century’ model, mark-1, based on the Pacific Asia dynamism shown by the ‘Asian Tigers’ and Japan. However, the Asian financial crash of 1997-8, and the economic downturn in Japan, meant that such an ‘Asian Century’ seemed premature as the 21st century arrived. Instead, it was China’s economic growth that seemed most evident, and with it the concept of the 21st century as ‘China’s Century’. However, in turn that has already been modified during the first decade of the century by India’s arrival as a rapidly growing economy. Consequently the 21st century as ‘China’s Century’ and as ‘India’s Century’ has been combined into talk of an ‘Asian Century’, mark-2.

  2. Drug and Alcohol Studies (Volume 4: Policy approaches)

    OpenAIRE

    Macgregor, S.; Thom, B

    2014-01-01

    VOLUME FOUR: POLICY APPROACHES Preface Robert MacCoun and Peter Reuter The Varieties of Drug Control at the Dawn of the 21st Century Comparative Analysis of Alcohol Control Policies in 30 Countries Donald Brand et al A Comparative Study of 38 European Countries Limited Rationality and the Limits of Supply Reduction Jonathan Caulkins and Robert MacCoun The Limited Relevance of Drug Policy Craig Reinerman, Peter Cohen and Hendrien Kaal Cannabis in Amsterdam and San Francisco AIDS and Injecting ...

  3. MicroRNA-10b downregulation mediates acute rejection of renal allografts by derepressing BCL2L11

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xiaoyou [Department of Organ Transplantation, Zhujiang Hospital, Guangzhou 510282 (China); Dong, Changgui [Institute of Molecular Ecology and Evolution, East China Normal University, Shanghai 200062 (China); Jiang, Zhengyao [Department of Organ Transplantation, Zhujiang Hospital, Guangzhou 510282 (China); Wu, William K.K. [Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, NT, Hong Kong (China); State Key Laboratory of Digestive Diseases, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong (China); Chan, Matthew T.V. [Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, NT, Hong Kong (China); Zhang, Jie [Department of Organ Transplantation, Zhujiang Hospital, Guangzhou 510282 (China); Li, Haibin; Qin, Ke [Guangxi Key Laboratory for Transplantation Medicine Department of Organ Transplantation in Guangzhou Military Region, Institute of Transplant Medicine, 303 Hospital of People' s Liberation Army, Nanning, Guangxi 530021 (China); Sun, Xuyong, E-mail: sunxuyong0528@163.com [Guangxi Key Laboratory for Transplantation Medicine Department of Organ Transplantation in Guangzhou Military Region, Institute of Transplant Medicine, 303 Hospital of People' s Liberation Army, Nanning, Guangxi 530021 (China)

    2015-04-10

    Kidney transplantation is the major therapeutic option for end-stage kidney diseases. However, acute rejection could cause allograft loss in some of these patients. Emerging evidence supports that microRNA (miRNA) dysregulation is implicated in acute allograft rejection. In this study, we used next-generation sequencing to profile miRNA expression in normal and acutely rejected kidney allografts. Among 75 identified dysregulated miRNAs, miR-10b was the most significantly downregulated miRNAs in rejected allografts. Transfecting miR-10b inhibitor into human renal glomerular endothelial cells recapitulated key features of acute allograft rejection, including endothelial cell apoptosis, release of pro-inflammatory cytokines (interleukin-6, tumor necrosis factor α, interferon-γ, and chemokine (C–C motif) ligand 2) and chemotaxis of macrophages whereas transfection of miR-10b mimics had opposite effects. Downregulation of miR-10b directly derepressed the expression of BCL2L11 (an apoptosis inducer) as revealed by luciferase reporter assay. Taken together, miR-10b downregulation mediates many aspects of disease pathogenicity of acute kidney allograft rejection. Restoring miR-10b expression in glomerular endothelial cells could be a novel therapeutic approach to reduce acute renal allograft loss. - Highlights: • miR-10b was the most downregulated microRNAs in acutely rejected renal allografts. • miR-10b downregulation triggered glomerular endothelial cell apoptosis. • miR-10b downregulation induced release of pro-inflammatory cytokines. • miR-10b downregulation derepressed its pro-apoptotic target BCL2L11.

  4. Differential effects in CGRPergic, nitrergic, and VIPergic myenteric innervation in diabetic rats supplemented with 2% L-glutamine

    Directory of Open Access Journals (Sweden)

    RENATA V.F. PEREIRA

    2016-01-01

    Full Text Available ABSTRACT The objective of this study was to investigate the effects of 2% L-glutamine supplementation on myenteric innervation in the ileum of diabetic rats, grouped as follows: normoglycemic (N; normoglycemic supplemented with L-glutamine (NG; diabetic (D; and diabetic supplemented with L-glutamine (DG. The ileums were subjected to immunohistochemical techniques to localize neurons immunoreactive to HuC/D protein (HuC/D-IR and neuronal nitric oxide synthase enzyme (nNOS-IR and to analyze varicosities immunoreactive to vasoactive intestinal polypeptide (VIP-IR and calcitonin gene-related peptide (CGRP-IR. L-Glutamine in the DG group (i prevented the increase in the cell body area of nNOS-IR neurons, (ii prevented the increase in the area of VIP-IR varicosities, (iii did not prevent the loss of HuC/D-IR and nNOS-IR neurons per ganglion, and (iv reduced the size of CGRP-IR varicosities. L-Glutamine in the NG group reduced (i the number of HuC/D-IR and nNOS-IR neurons per ganglion, (ii the cell body area of nNOS-IR neurons, and (iii the size of VIP-IR and CGRP-IR varicosities. 2% L-glutamine supplementation exerted differential neuroprotective effects in experimental diabetes neuropathy that depended on the type of neurotransmitter analyzed. However, the effects of this dose of L-glutamine on normoglycemic animals suggests there are additional actions of this beyond its antioxidant capacity.

  5. Enrichment of variations in KIR3DL1/S1 and KIR2DL2/L3 among H1N1/09 ICU patients: an exploratory study.

    Directory of Open Access Journals (Sweden)

    David La

    Full Text Available BACKGROUND: Infection by the pandemic influenza A (H1N1/09 virus resulted in significant pathology among specific ethnic groups worldwide. Natural Killer (NK cells are important in early innate immune responses to viral infections. Activation of NK cells, in part, depend on killer-cell immunoglobulin-like receptors (KIR and HLA class I ligand interactions. To study factors involved in NK cell dysfunction in overactive immune responses to H1N1 infection, KIR3DL1/S1 and KIR2DL2/L3 allotypes and cognate HLA ligands of H1N1/09 intensive-care unit (ICU patients were determined. METHODOLOGY AND FINDINGS: KIR3DL1/S1, KIR2DL2/L3, and HLA -B and -C of 51 H1N1/09 ICU patients and 105 H1N1-negative subjects (St. Theresa Point, Manitoba were characterized. We detected an increase of 3DL1 ligand-negative pairs (3DL1/S1(+ Bw6(+ Bw4(-, and a lack of 2DL1 HLA-C2 ligands, among ICU patients. They were also significantly enriched for 2DL2/L3 ligand-positive pairs (PVA, P=0.024, Pc=0.047; Odds Ratio:2.563, CI95%:1.109-5.923, 3DL1*00101 (Ab>VA, PSTh, P=0.034, Pc=0.268, and 3DL1*029 (Ab>STh, P=0.039, Pc=0.301. Aboriginal patients ligand-positive for 3DL1/S1 and 2DL1 had the lowest probabilities of death (R(d (R(d=28%, compared to patients that were 3DL1/S1 ligand-negative (R(d=52% or carried 3DL1*029 (R(d=52%. Relative to Caucasoids (CA, two allotypes were enriched among non-aboriginal ICU patients (NAb: 3DL1*00401 (NAb>CA, P<0.001, Pc<0.001 and 3DL1*01502 (CA2/L3, and 2DL1 had the lowest probabilities of death (R(d=36%, compared to subjects with 3DL1*01502 (R(d=48% and/or 3DL1*00401 (R(d=58%. CONCLUSIONS: Specific KIR3DL1/S1 allotypes, 3DL1/S1 and 2DL1 ligand-negative pairs, and 2DL2/L3 ligand-positive pairs were enriched among ICU patients. This suggests a possible association with NK cell dysfunction in patients with overactive immune responses to H1N1/09, leading to

  6. Nursing theory: the 21st century.

    Science.gov (United States)

    Randell, B P

    1992-01-01

    On September 21, 1990, at the University of California, Los Angeles, Neuropsychiatric Institute and Hospital, six nurse theorists participated in a panel discussion on theory development for the 21st century. The theorists included Dorothy Johnson, Betty Neuman, Dorothea E. Orem, Rosemarie Rizzo Parse, Martha E. Rogers and Callista Roy. The panel provided the participants the opportunity to speculate on the course for future development of nursing knowledge. Three questions were posed to the panel relating to the development of their models, the direction nursing theory will take in the 21st century, and current research emerging from the extant theories. The panel also addressed questions from the audience.

  7. Omsorg/støtte i ungdomsskolen

    OpenAIRE

    Vasseng, Eli Dahl

    2012-01-01

    Denne studien handler om forholdet mellom lærer-elev og ser på hvordan ungdomsskoleelever beskriver omsorgsfulle/støttende lærere og den betydning det har for motivasjon i skolearbeid og læringsmiljø. Jeg har tatt utgangspunkt i ungdomsskoleelevenes forståelse av fenomenet omsorg/støtte og brukt en fenomenologisk tilnærming med intervju som metode. Seks elever fra ungdomstrinnet ble intervjuet og jeg har brukt en intervjuguide som er bygget på det teoretiske rammeverket i oppgaven. Hovedt...

  8. 51st North American Chemical Residue Workshop.

    Science.gov (United States)

    Yang, Paul; Martos, Perry; Barrett, Brad

    2015-06-03

    Manuscripts collected in this 51st North American Chemical Residue Workshop (NACRW) Symposium issue of the Journal of Agricultural and Food Chemistry (JAFC) were originally presented at the 51st NACRW meeting. The 2014 NACRW JAFC symposium collects 14 publications representing the broad range of topics in chemical analyses presented at the 2014 meeting. These include the analysis of chemical residues and contaminants in food, environment, feed, botanical, and bee samples as well as the application of quality control/quality assurance protocols in routine and method development.

  9. Statistics in the 21st century

    CERN Document Server

    Wells, Martin T; Wells, Martin T

    2001-01-01

    Exactly what is the state of the art in statistics as we move forward into the 21st century? What promises, what trends does its future hold? Through the reflections of 70 of the world's leading statistical methodologists, researchers, theorists, and practitioners, Statistics in the 21st Century answers those questions. Originally published in the Journal of the American Statistical Association, this collection of vignettes examines our statistical past, comments on our present, and speculates on our future. Although the coverage is broad and the topics diverse, it reveals the essential intell

  10. Operation and maintenance in ST-MA

    CERN Document Server

    Nunes, R

    2003-01-01

    This paper will review the Operation & Maintenance (O&M) activities in the ST-MA group, giving an overview of the services provided by the Group as well as the contract activities. As an introduction, a conceptual framework for O&M is proposed in order to better situate the domains of Operation and Maintenance respectively. The ST-MA activities shall be looked at through the three main service axes and special emphasis will be given to the contractual implementation, supervision and follow-up methodology.

  11. Palynology, age, correlation, and paleoclimatology from JAPEX/JNOC/GSC Mallik 2L-38 gas hydrate research well and the significance for gas hydrate: a new approach

    National Research Council Canada - National Science Library

    White, J M

    2009-01-01

    A quantitative palynological study of a 480 m section of mid-Cenozoic sediment from the Mallik 2L-38 gas hydrate research borehole, Mackenzie River delta, is based on core and high-quality cuttings...

  12. Functional Analysis of CP2-Like Domain and SAM-Like Domain in TFCP2L1, Novel Pluripotency Factor of Embryonic Stem Cells.

    Science.gov (United States)

    Kim, Chang Min; Jang, Tae-Ho; Park, Hyun Ho

    2016-06-01

    TFCP2L1 is a transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells by forming a complex transcriptional network with other transcription factors (OCT4, SOX2, and NANOG). TFCP2L1 contains two distinct domains, the CP2-like domain at the N-terminus and the SAM-like domain at the C-terminus. In this study, we found that TFCP2L1 is hexamerized in solution via the C-terminal SAM-like domain. We also found that homo-oligomerization of SAM-like domain is dependent on the concentration of the proteins. Finally, we found that TFCP2L1 binds directly to DNA via the N-terminal CP2-like domain.

  13. COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation.

    Science.gov (United States)

    Pérez-Pérez, Rafael; Lobo-Jarne, Teresa; Milenkovic, Dusanka; Mourier, Arnaud; Bratic, Ana; García-Bartolomé, Alberto; Fernández-Vizarra, Erika; Cadenas, Susana; Delmiro, Aitor; García-Consuegra, Inés; Arenas, Joaquín; Martín, Miguel A; Larsson, Nils-Göran; Ugalde, Cristina

    2016-08-30

    Mitochondrial respiratory chain (MRC) complexes I, III, and IV associate into a variety of supramolecular structures known as supercomplexes and respirasomes. While COX7A2L was originally described as a supercomplex-specific factor responsible for the dynamic association of complex IV into these structures to adapt MRC function to metabolic variations, this role has been disputed. Here, we further examine the functional significance of COX7A2L in the structural organization of the mammalian respiratory chain. As in the mouse, human COX7A2L binds primarily to free mitochondrial complex III and, to a minor extent, to complex IV to specifically promote the stabilization of the III2+IV supercomplex without affecting respirasome formation. Furthermore, COX7A2L does not affect the biogenesis, stabilization, and function of the individual oxidative phosphorylation complexes. These data show that independent regulatory mechanisms for the biogenesis and turnover of different MRC supercomplex structures co-exist.

  14. Quality Horizons. Volume I.

    Science.gov (United States)

    1979-11-15

    PRODUCTS PRODUCTS Bruel & Kjaer Standard Electric GOVERNMENT AGENCIES US Embassy Office of Defense Cooperation Ministry of Commerce Royal Danish Air Force...Combined Material Agency (DCMA) BELGIUM COMMERCIAL & MILITARY PRODUCTS MBLE (Manufacture Beige DeLampes St De Materiel Electronique ) GOVERnMENT AGENCIES

  15. COX7A2L is a mitochondrial complex III-binding protein that stabilizes the III2+IV supercomplex without affecting respirasome formation

    OpenAIRE

    Pérez-Pérez, Rafael; Lobo-Jarne, Teresa; Milenkovic, Dusanka; Mourier, Arnaud; Bratic, Ana; García-Bartolomé, Alberto; Fernández-Vizarra, Erika; Cadenas, Susana; Delmiro, Aitor; García-Consuegra, Inés; Arenas, Joaquín; Martín, Miguel A.; Larsson, Nils-Göran; Ugalde, Cristina

    2016-01-01

    Mitochondrial respiratory chain (MRC) complexes I, III and IV associate into a variety of supramolecular structures known as supercomplexes and respirasomes. While COX7A2L was originally described as a supercomplex-specific factor responsible for the dynamic association of complex IV into these structures to adapt MRC function to metabolic variations, this role has been disputed. Here we further examine the functional significance of COX7A2L in the structural organization of the mammalian res...

  16. COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation

    OpenAIRE

    Rafael Pérez-Pérez; Teresa Lobo-Jarne; Dusanka Milenkovic; Arnaud Mourier; Ana Bratic; Alberto García-Bartolomé; Erika Fernández-Vizarra; Susana Cadenas; Aitor Delmiro; Inés García-Consuegra; Joaquín Arenas; Miguel A. Martín; Nils-Göran Larsson; Cristina Ugalde

    2016-01-01

    Mitochondrial respiratory chain (MRC) complexes I, III, and IV associate into a variety of supramolecular structures known as supercomplexes and respirasomes. While COX7A2L was originally described as a supercomplex-specific factor responsible for the dynamic association of complex IV into these structures to adapt MRC function to metabolic variations, this role has been disputed. Here, we further examine the functional significance of COX7A2L in the structural organization of the mammalian r...

  17. Volume Regulated Channels

    DEFF Research Database (Denmark)

    Klausen, Thomas Kjær

    - serves a multitude of functions in the mammalian cell, regulating the membrane potential (Em), cell volume, protein activity and the driving force for facilitated transporters giving Cl- and Cl- channels a major potential of regulating cellular function. These functions include control of the cell cycle...... of volume perturbations evolution have developed system of channels and transporters to tightly control volume homeostasis. In the past decades evidence has been mounting, that the importance of these volume regulated channels and transporters are not restricted to the defense of cellular volume......, controlled cell death and cellular migration. Volume regulatory mechanisms has long been in focus for regulating cellular proliferation and my thesis work have been focusing on the role of Cl- channels in proliferation with specific emphasis on ICl, swell. Pharmacological blockage of the ubiquitously...

  18. Reality Therapy for the 21st Century.

    Science.gov (United States)

    Wubbolding, Robert E.

    This book serves as a comprehensive and practical guide to reality therapy, and extends its principles and practices beyond the initial descriptions. A central theme of this edition is that reality therapy is a method inherently designed for the exigencies of the 21st century. It contains 22 types of self-evaluations counselors can use to shorten…

  19. St\\"uckelberg Formulation of Holography

    CERN Document Server

    Dvali, Gia; Wintergerst, Nico

    2015-01-01

    We suggest that holography can be formulated in terms of the information capacity of the St\\"uckelberg degrees of freedom that maintain gauge invariance of the theory in the presence of an information boundary. These St\\"uckelbergs act as qubits that account for a certain fraction of quantum information. Their information capacity is measured by the ratio of the inverse St\\"uckelberg energy gap to the size of the system. Systems with the smallest gap are maximally holographic. For massless gauge systems this information measure is universally equal to the inverse coupling evaluated at the systems' length scale. In this language it becomes very transparent why the St\\"uckelberg information capacity of black holes saturates the Bekenstein bound and accounts for the entire information of the system. The physical reason is that the strength of quantum interaction is bounded from below by the gravitational coupling, which scales as area. Observing the striking similarity between the scalings of the energy gap of t...

  20. Støtte til vedvarende energi?

    DEFF Research Database (Denmark)

    Olsen, Ole Jess; Skytte, Klaus; Grenaa Jensen, Stine

    er gået mere trægt. Hvad er forklaringen på de meget forskellige erfaringer? Kan succesen gentages for andre teknologier blot ved at kopiere støtte- og rammebetingelserne fra vindkraft? Disse spørgsmål søges besvaret i bogen. Erfaringskurver og relevant innovationsteori gennemgås, og der opstilles en...

  1. Creating 21st Century Learning Environments

    Science.gov (United States)

    Li, Phan P.; Locke, John; Nair, Prakash; Bunting, Andrew

    2005-01-01

    What is involved in creating learning environments for the 21st century? How can school facilities serve as tools for teaching and meet the needs of students in the future? What components are required to design effective schools, and how does architecture relate to the purposes of schooling? These are some of the questions addressed at the…

  2. Soaring into the 21st Century.

    Science.gov (United States)

    Burke, John

    1993-01-01

    Describes the implementation of ideas from the National Congress on Catholic Schools for the 21st Century at Saint Thomas Aquinas School in the South Bronx. Discusses Catholic identity, school spirit, social change, and school development with respect to the school's long-range planning for success in an economically depressed neighborhood. (MAB)

  3. St. Vincent Island : Then and Now

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report captures the memories and observations of Charles F. Marks, Jr. who lived on St. Vincent Island as a child. He recalls what it was like growing up on the...

  4. Toward the 21st Century for Women

    Science.gov (United States)

    Osborn, Ruth H.

    1975-01-01

    The International Women's Year Conference decided that the key to the future for women throughout the world was continuing education enabling women to gain a sense of self realization, promote family life, increase options, and to contribute their talents to a better world in the 21st century. (Author/BP)

  5. St. Louis Educational Museum: A Centennial Commemoration

    Science.gov (United States)

    Allen, James A.

    2005-01-01

    The St. Louis, Missouri Educational Museum has its roots in the 1904 Centennial Exposition, held at Forest Park on the edge of the city. The theme of the exposition was education and technology. Seventy thousand local school children visited the exposition, and at its conclusion an initiative was launched to purchase some of the exhibitions as…

  6. St Vincent Youth and Careers in Agriculture

    Science.gov (United States)

    Webster, Nicole; Ganpat, Wayne

    2014-01-01

    Purpose: Given the ageing farming population in the Caribbean and the importance of agriculture to economy, there is cause for concern about the future of farming. This study seeks to explore the extent to which students pursuing agriculture in secondary schools in St Vincent and the Grenadines (SVG) were likely to engage in farming as well as…

  7. Possible Future SOFC - ST Based Power Plants

    DEFF Research Database (Denmark)

    Rokni, Masoud; Scappin, Fabio

    2009-01-01

    Hybrid systems consisting Solid Oxide Fuel Cell (SOFC) on the top of a Steam Turbine (ST) are investigated. The plants are fired by natural gas. A desulfurization reactor removes the sulfur content in the NG while a pre-reformer break down the heavier hydrocarbons. The pre-treated fuel enters...

  8. The 21st Century Information Environment.

    Science.gov (United States)

    Badger, Rod

    This paper on the 21st century information environment begins with a section that discusses the impact of e-commerce over the next ten years. The second section addresses government focus areas, including ensuring a telecommunications infrastructure, developing the IT (information technology) industry, promoting innovation and entrepreneurship,…

  9. Action Research at St Mark's Academy 2013

    Science.gov (United States)

    Elwick, Alex, Ed.; Riggall, Anna, Ed.

    2013-01-01

    St Mark's Church of England Academy is an 11-18 academy situated in Mitcham, South London. It offers a commitment to high achievement within a community of care, underpinned by the Christian values of hope, love and trust. The academy encourages the development of the moral and spiritual well-being of students, alongside their academic success.…

  10. Material Connections: Steuart Building, St. Albans School.

    Science.gov (United States)

    Stephens, Suzanne

    1980-01-01

    The addition to the St. Albans campus in Washington, D.C., relates both to the style and the siting of the older "collegiate gothic" school nearby. The mixed-use building contains five classrooms, art and music spaces, and a student lounge. (Author/MLF)

  11. St Vincent Youth and Careers in Agriculture

    Science.gov (United States)

    Webster, Nicole; Ganpat, Wayne

    2014-01-01

    Purpose: Given the ageing farming population in the Caribbean and the importance of agriculture to economy, there is cause for concern about the future of farming. This study seeks to explore the extent to which students pursuing agriculture in secondary schools in St Vincent and the Grenadines (SVG) were likely to engage in farming as well as…

  12. Bathymetry (2011) for Coral Bay, St. John

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 0.3x0.3 meter resolution depth surface for Coral Bay, St. John in the U.S. Virgin Islands (USVI). The...

  13. Learning Analytics for 21st Century Competencies

    Science.gov (United States)

    Buckingham Shum, Simon; Crick, Ruth Deakin

    2016-01-01

    Many educational institutions are shifting their teaching and learning towards equipping students with knowledge, skills, and dispositions that prepare them for lifelong learning, in a complex and uncertain world. These have been termed "21st century competencies." Learning analytics (LA) approaches in general offer different kinds of…

  14. Highlights of 41st IATEFL Conference (Ⅱ)

    Institute of Scientific and Technical Information of China (English)

    Rathi Manohar

    2007-01-01

    @@ For this year's 41 st International Annual IATEFL Conference in Aberdeen,IATEFL and the British Council worked together to enable teacher audiences worldwide to participate in this year's IATEFL Conference via the interact and get a taste of exactly what happens over four exciting days each year around Easter.

  15. Eesti goes St. Etienne / Anna Roomet

    Index Scriptorium Estoniae

    Roomet, Anna

    2006-01-01

    Näitus Eesti Kunstiakadeemia tootedisaini osakonna magistrantide viimase kahe aasta projektide paremikust esindas Eestit disainibiennaalil St. Etiennis Prantsusmaal. Näituse panid üles Pent Talvet ja Pavel Sidorenko, näitusel osalejad: Anna-Maria Einla, Kätlin Kangur, Triin Kuusler, Andri Laidre, Veiko Liis, Liina-Kai Raivet, P. Sidorenko, P. Talvet, Ingela Viks, Triin Voss

  16. Ambulant ST-segmentmonitorering efter akut myokardieinfarkt

    DEFF Research Database (Denmark)

    Mickley, H; Junker, A; Friis, E V

    1994-01-01

    Over the last decade the concept of silent myocardial ischaemia has received considerable attention. Without doubt, the increased use of ambulatory ST-segment monitoring is the most important reason for the growing interest in this field. The prevalence of ambulatory ischaemia after myocardial in...

  17. Bathymetry (2011) for Fish Bay, St. John

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 0.3x0.3 meter resolution depth surface for Fish Bay, St. John in the U.S. Virgin Islands (USVI). The...

  18. Digital Humanities in the 21st Century

    DEFF Research Database (Denmark)

    Brügger, Niels

    2016-01-01

    In this article it is argued that one of the major transformative factors of the humanities at the beginning of the 21st century is the shift from analogue to digital source material, and that this shift will affect the humanities in a variety of ways. But various kinds of digital material...

  19. Silencing SlELP2L, a tomato Elongator complex protein 2-like gene, inhibits leaf growth, accelerates leaf, sepal senescence, and produces dark-green fruit.

    Science.gov (United States)

    Zhu, Mingku; Li, Yali; Chen, Guoping; Ren, Lijun; Xie, Qiaoli; Zhao, Zhiping; Hu, Zongli

    2015-01-09

    The multi-subunit complex Elongator interacts with elongating RNA polymerase II (RNAPII) and is thought to facilitate transcription through histone acetylation. Elongator is highly conserved in eukaryotes, yet has multiple kingdom-specific functions in diverse organisms. Recent genetic studies performed in Arabidopsis have demonstrated that Elongator functions in plant growth and development, and in response to biotic and abiotic stress. However, little is known about its roles in other plant species. Here, we study the function of an Elongator complex protein 2-like gene in tomato, here designated as SlELP2L, through RNAi-mediated gene silencing. Silencing SlELP2L in tomato inhibits leaf growth, accelerates leaf and sepal senescence, and produces dark-green fruit with reduced GA and IAA contents in leaves, and increased chlorophyll accumulation in pericarps. Gene expression analysis indicated that SlELP2L-silenced plants had reduced transcript levels of ethylene- and ripening-related genes during fruit ripening with slightly decreased carotenoid content in fruits, while the expression of DNA methyltransferase genes was up-regulated, indicating that SlELP2L may modulate DNA methylation in tomato. Besides, silencing SlELP2L increases ABA sensitivity in inhibiting seedling growth. These results suggest that SlELP2L plays important roles in regulating plant growth and development, as well as in response to ABA in tomato.

  20. Synthesis and Crystal Structure of a One-dimensional Ladder-like Complex [Cu2(L)(dca)2]n (dca = [N(CN)2]-,L = 1,4-Bis(3-furanyl)-2,3-diaza-1,3-butadiene)

    Institute of Scientific and Technical Information of China (English)

    ZHAO Qi-Hua; ZHAO Hui; DU Lin; FANG Rui-Bin

    2008-01-01

    A new Cu(I)-dicyanamide with formula [Cu2(L)(dca)2]n (dca = dicyanamide anion, L = 1,4-bis(3-furanyl)-2,3-diaza-1,3-butadiene) has been synthesized and structurally characterized.The complex crystallizes in the monoclinic system, space group P21/n with a = 9.271(2), b = 7.7355(16), c = 11.967(3) -, β = 102.693(3)°, V = 837.3(3) -3, Z = 4, Mr = 223.68, Dc = 1.775 g/cm3, μ(MoKα) = 2.567 mm-1, F(000) = 444, R = 0.0782 and wR = 0.2582 for 951 observed reflections (I > 2σ(I)).Single-crystal X-ray analysis reveals that the copper atom is three-coordinated by two nitrogen atoms from two dicyanamide anions and another one from the ligand, and each copper atom is connected by two [N(CN)2]- anions to form an infinite double-stranded bridge fashion leading to 1D ladder-like motifs.

  1. Henkilöstötilinpäätös ja henkilöstöstrategian pohja kohdeyritykselle

    OpenAIRE

    Jäntti, Hanna

    2013-01-01

    Tämän toiminnallisen opinnäytetyön kautta tuotettiin kohdeyritykselle henkilöstötilinpäätös sekä pohja henkilöstöstrategialle. Työn toimeksiantaja oli Pohjois-Suomen alueella toimiva kehitysvammaisten palvelukoti, joka myy kehitysvammaispalveluilta kunnille sekä yksityisille yrityksille ja henkilöille. Henkilöstötilinpäätöstä tai henkilöstöstrategiaa ei ollut organisaatiossa aiemmin tehty. Opinnäytetyö jakaantui varsinaiseen opinnäytetyöraporttiin ja sen liitteinä oleviin henkilöstötilinp...

  2. Precision volume measurement system.

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Erin E.; Shugard, Andrew D.

    2004-11-01

    A new precision volume measurement system based on a Kansas City Plant (KCP) design was built to support the volume measurement needs of the Gas Transfer Systems (GTS) department at Sandia National Labs (SNL) in California. An engineering study was undertaken to verify or refute KCP's claims of 0.5% accuracy. The study assesses the accuracy and precision of the system. The system uses the ideal gas law and precise pressure measurements (of low-pressure helium) in a temperature and computer controlled environment to ratio a known volume to an unknown volume.

  3. "Sensoro spēju attīstība nodarbībās bērniem vecumā no 2-3 gadiem, izmantojot Montesori metodiku"

    OpenAIRE

    Billerte, Anna

    2016-01-01

    Kvalifikācijas darba „Sensoro spēju attīstība nodarbībās bērniem vecumā no 2 līdz 3 gadiem, izmantojot Montesori metodiku” mērķis - izpētīt bērnu attīstību no 2 līdz 3 gadu vecumam, nosakot Montesori metodikas lomu bērnu sensoro spēju attīstīšanā. Tika veikts analītisks pētījums par bērnu attīstības teorētiskajām nostādnēm un Montesori pedagoģijas pamatbūtību, īpašu uzmanību veltot sensorās attīstības veicināšanai domātajiem materiāliem. Tika veikts praktisks pētījums par bērnu sensoro spēju...

  4. LiDAR Relative Reflectivity Surface (2011) for the St. Thomas East End Reserve, St. Thomas

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 0.3x0.3 meter resolution relative seafloor reflectivity surface for the St. Thomas East End Reserve...

  5. Habitat Management Plan for St. Marks National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The St. Marks NWR Habitat Management Plan provides a long-term vision and specific guidance on managing habitats for the resources of concern at St. Marks NWR, to...

  6. Danish Stød: Laryngealization or Tone

    DEFF Research Database (Denmark)

    Grønnum, Nina; Vazquez-Larruacaín, Miguel; Basbøll, Hans

    2013-01-01

    In the light of previous acoustic analyses of Danish stød and Danish intonation, we discuss two different phonological theories. In one, stød is an autonomous laryngeal syllable prosody. In the other, stød is the phonetic manifestation of a HL tonal pattern compressed within one syllable. The tonal...... representation is found to be contradicted by the phonetic reality, and it cannot account for the structurally determined alternation between non-stød and stød in inflection and derivation, nor for latent stød or stød in compounds. Furthermore, stød patterns are largely constant across regional varieties...

  7. CDC WONDER: Population - Bridged-Race July 1st Estimates

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Population - Bridged-Race July 1st Estimates online databases report bridged-race population estimates of the July 1st resident population of the United States,...

  8. A New Class of Group Field Theories for 1st Order Discrete Quantum Gravity

    CERN Document Server

    Oriti, Daniele

    2007-01-01

    Group Field Theories, a generalization of matrix models for 2d gravity, represent a 2nd quantization of both loop quantum gravity and simplicial quantum gravity. In this paper, we construct a new class of Group Field Theory models, for any choice of spacetime dimension and signature, whose Feynman amplitudes are given by path integrals for clearly identified discrete gravity actions, in 1st order variables. In the 3-dimensional case, the corresponding discrete action is that of 1st order Regge calculus for gravity (generalized to include higher order corrections), while in higher dimensions, they correspond to a discrete BF-theory (again, generalized to higher order) with an imposed orientation restriction on hinge volumes, similar to that characterizing discrete gravity. The new models shed also light on the large distance or semi-classical approximation of spin foam models. This new class of group field theories may represent a concrete unifying framework for loop quantum gravity and simplicial quantum grav...

  9. Associations of Circulating Growth Differentiation Factor-15 and ST2 Concentrations With Subclinical Vascular Brain Injury and Incident Stroke

    DEFF Research Database (Denmark)

    Andersson, Charlotte; Preis, Sarah R; Beiser, Alexa;

    2015-01-01

    .04). Higher GDF-15 concentrations were also associated with greater log-transformed white-matter hyperintensity volumes (β for Q4 versus Q1=0.19; P=0.01). Prospectively, a total of 203 (6%) individuals developed incident stroke/transient ischemic attack during follow-up. After multivariable adjustment, sST2...... remained significantly associated with stroke/transient ischemic attack, hazard ratio for Q4 versus Q1 of 1.76, 95% confidence interval of 1.06 to 2.92, and P=0.03. CONCLUSIONS: Circulating GDF-15 and sST2 are associated with subclinical brain injury and cognitive impairment. Higher sST2 concentrations...

  10. A Back-to-Back 2L-3L Grid Integration of a Marine Current Energy Converter

    Directory of Open Access Journals (Sweden)

    Senad Apelfröjd

    2015-01-01

    Full Text Available The paper proposes a back-to-back 2L-3L grid connection topology for a marine current energy converter. A prototype marine current energy converter has been deployed by a research group at Uppsala University. The concept behind the prototype revolves around a fixed pitch vertical axis turbine directly connected to a permanent magnet synchronous generator (PMSG. The proposed grid connection system utilizes a well known and proven two level voltage source converter generator-side combined with a three-level cascaded H-bridge (CHB multilevel converter grid-side. The multilevel converter brings benefits in terms of efficiency, power quality and DC-link utilization. The system is here presented for a single marine current energy converter but can easily be scaled up for clusters of marine current energy converters. Control schemes for both grid-side and generator-side voltage source converters are presented. The start-up, steady state and dynamic performance of the marine current energy converter are investigated and simulation results are presented in this paper.

  11. KK MC-hh: Resumed exact O (α2L ) EW corrections in a hadronic MC event generator

    Science.gov (United States)

    Jadach, S.; Ward, B. F. L.; Was, Z. A.; Yost, S. A.

    2016-10-01

    We present an improvement of the Monte Carlo (MC) event generator Herwiri2, where we recall the latter MC was a prototype for the inclusion of CEEX resummed electroweak (EW) corrections in hadron-hadron scattering at high center of momentum system (cms) energies. In this improvement the new exact O (α2L ) resummed EW generator K K MC 4.22, featuring as it does the CEEX realization of resummation in the EW sector, is put in union with the Herwig parton shower environment. The Les Houches (LHE) format of the attendant output event file means that all other conventional parton shower environments are available to the would-be user of the resulting new MC. For this reason (and others—see the text) we henceforth refer to the new improvement of the Herwiri2 MC as K K MC -hh. Since this new MC features exact O (α ) pure weak corrections from the DIZET EW library and features the CEEX and the EEX YFS-style resummation of large multiple photon effects, it provides already the concrete path to 0.05% precision on such effects if we focus on the EW effects themselves. We therefore show predictions for observable distributions and comparisons with other approaches in the literature. This MC represents an important step in the realization of the exact amplitude-based QED ⊗QCD resummation paradigm. Independently of this latter observation, the MC rigorously quantifies important EW effects in the current LHC experiments.

  12. Comparative analyses of $B\\to K_2^*l^+l^-$ in the standard model and new physics scenarios

    CERN Document Server

    Li, Run-Hui; Wang, Wei

    2010-01-01

    We analyze the $B\\to K_2^*(\\to K\\pi)l^+l^-$ (with $l=e,\\mu,\\tau$) decay in the standard model and two new physics scenarios: vector-like quark model and family non-universal $Z'$ model. We derive the differential angular distributions of the quasi-four-body decay, using the recently calculated form factors in the perturbative QCD approach. Branching ratios, polarizations, forward-backward asymmetries and transversity amplitudes are predicted, from which we find a promising prospective to observe this channel on the future experiment. We also update the constraints on effective Wilson coefficients and/or free parameters in these two new physics scenarios by making use of the experimental data of $B\\to K^*l^+l^-$ and $b\\to sl^+l^-$. Their impact on $B\\to K_2^*l^+l^-$ is subsequently explored and in particular the zero-crossing point for the forward-backward asymmetry in these new physics scenarios can sizably deviate from the SM scenario. In addition we also generalize the analysis to a similar mode $B_s\\to f_2...

  13. Scientific results from JAPEX/JNOC/GSC Mallik 2L-38 gas hydrate research well, Mackenzie Delta, Northwest Territories, Canada

    Energy Technology Data Exchange (ETDEWEB)

    Dallimore, S.R. [ed.] [Geological Survey of Canada, Ottawa, ON (Canada); Uchida, T. [ed.] [JAPEX Research Center, Chiba (Japan); Collett, T.S. [ed.] [United States Geological Survey, Denver, CO (United States)

    1999-10-01

    A general overview was presented of a joint research project involving Canada, the United States and Japan. The project involved the drilling of the JAPEX/JNOC/GSC Mallik 2L-38 gas hydrate research well to examine the occurrence of natural gas hydrate beneath permafrost. The 1150 m deep gas hydrate well, which is located on the northeastern edge of the Mackenzie Delta, Northwest Territories was completed in March 1998. This book presents the scientific results from the well program. It is meant to assess regional issues related to gas hydrate occurrences in the Mackenzie Delta area. An operations overview of the project was presented along with the regional geology, gas hydrate setting, and the ground-thermal conditions of the Mackenzie Delta region. 19 papers were also included which provided a comprehensive review of the core data collected in the well. The studies were grouped into the following subjects: (1) geology and biostratigraphy, (2) geophysical properties, (3) geochemistry, (4) gas hydrate characterization, and (5) downhole geophysics. One well log and three maps were included with this bulletin. refs., tabs., figs.

  14. Phenomenology of the SU(3)_C \\otimes SU(2)_L \\otimes SU(3)_R \\otimes U(1)_X gauge model

    CERN Document Server

    Dong, P V; Loi, D V; Nhuan, N T; Ngan, N T K

    2016-01-01

    We study the left-right asymmetric model based on SU(3)_C\\otimes SU(2)_L \\otimes SU(3)_R\\otimes U(1)_X gauge group, which improves the theoretical and phenomenological aspects of the known left-right symmetric model. This new gauge symmetry yields that the fermion generation number is three, and the tree-level flavor-changing neutral currents arise in both gauge and scalar sectors. Also, it can provide the observed neutrino masses as well as dark matter automatically. Further, we investigate the mass spectrum of the gauge and scalar fields. All the gauge interactions of the fermions and scalars are derived. We examine the tree-level contributions of the new neutral vector, Z'_R, and new neutral scalar, H_2, to flavor-violating neutral meson mixings, say K-\\bar{K}, B_d-\\bar{B}_d, and B_s-\\bar{B}_s, which strongly constrain the new physics scale as well as the elements of the right-handed quark mixing matrices. The bounds for the new physics scale are in agreement with those coming from the \\rho-parameter as we...

  15. The Role of Bcl-2 Family Proteins in Therapy Responses of Malignant Astrocytic Gliomas: Bcl2L12 and Beyond

    Directory of Open Access Journals (Sweden)

    Fotini M. Kouri

    2012-01-01

    Full Text Available Glioblastoma (GBM is a highly aggressive and lethal brain cancer with a median survival of less than two years after diagnosis. Hallmarks of GBM tumors include soaring proliferative indices, high levels of angiogenesis, diffuse invasion into normal brain parenchyma, resistance toward therapy-induced apoptosis, and pseudopallisading necrosis. Despite the recent advances in neurosurgery, radiation therapy, and the development of targeted chemotherapeutic regimes, GBM remains one of the deadliest types of cancer. Particularly, the alkylating agent temozolomide (TMZ in combination with radiation therapy prolonged patient survival only marginally, and clinical studies assessing efficacies of targeted therapies, foremost ATP mimetics inhibiting the activity of receptor tyrosine kinases (RTKs, revealed only few initial responders; tumor recurrence is nearly universal, and salvage therapies to combat such progression remain ineffective. Consequently, myriad preclinical and clinical studies began to define the molecular mechanisms underlying therapy resistance of GBM tumors, and pointed to the Bcl-2 protein family, in particular the atypical member Bcl2-Like 12 (Bcl2L12, as important regulators of therapy-induced cell death. This review will discuss the multi-faceted modi operandi of Bcl-2 family proteins, describe their roles in therapy resistance of malignant glioma, and outline current and future drug development efforts to therapeutically target Bcl-2 proteins.

  16. Variable volume combustor

    Energy Technology Data Exchange (ETDEWEB)

    Ostebee, Heath Michael; Ziminsky, Willy Steve; Johnson, Thomas Edward; Keener, Christopher Paul

    2017-01-17

    The present application provides a variable volume combustor for use with a gas turbine engine. The variable volume combustor may include a liner, a number of micro-mixer fuel nozzles positioned within the liner, and a linear actuator so as to maneuver the micro-mixer fuel nozzles axially along the liner.

  17. 75 FR 8390 - St. Croix River Aids to Navigation

    Science.gov (United States)

    2010-02-24

    ... SECURITY Coast Guard St. Croix River Aids to Navigation AGENCY: Coast Guard, DHS. ACTION: Notice of public... the aids to navigation in the St. Croix River. DATES: A public meeting will be held on Tuesday, March... review the current Aids to Navigation system on the St. Croix River and discuss concerns and...

  18. Volume Regulated Channels

    DEFF Research Database (Denmark)

    Klausen, Thomas Kjær

    of volume perturbations evolution have developed system of channels and transporters to tightly control volume homeostasis. In the past decades evidence has been mounting, that the importance of these volume regulated channels and transporters are not restricted to the defense of cellular volume...... but are also essential for a number of physiological processes such as proliferation, controlled cell death, migration and endocrinology. The thesis have been focusing on two Channels, namely the swelling activated Cl- channel (ICl, swell) and the transient receptor potential Vanilloid (TRPV4) channel. I: Cl......- serves a multitude of functions in the mammalian cell, regulating the membrane potential (Em), cell volume, protein activity and the driving force for facilitated transporters giving Cl- and Cl- channels a major potential of regulating cellular function. These functions include control of the cell cycle...

  19. GeoTIFF of 3x3 m Bathymetry for St. Thomas & St. John, 2011, UTM 20N NAD83

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 3x3 meter resolution bathymetric surface for an area of shallow seabed surrounding St. Thomas and St....

  20. Life Sciences in the 21 st Century

    Institute of Scientific and Technical Information of China (English)

    Zou Chenglu (C. L. Tsou)

    2001-01-01

    This article presents a retrospective of the achievements of life sciences in the 20th century and a prospective in the 21 st century.primarily,because of the emergence of molecular biology in the 20th cetury,life sciences have grown up from a descriptive discipline to an exact science.Biology in the 21st century features a unification between analysis and integration,i.e.the unification of analysis and func-tional research.More and more interdisciplinary integration will be based on works of penetrating analyses.Secondly.the deeper understanding of all living phenomena will lead to a unified connition of the essence of life so that general biology in the genuine sese of the term will come into being.finally,basic research on the life sciences will produce an unprecedented influence on all aspects of human life.

  1. Danmarks Største Fossiler

    DEFF Research Database (Denmark)

    Lindow, Bent Erik Kramer; Cuny, Gilles Guy Roger

    2008-01-01

    For 8 millioner år siden myldrede Nordsøen af en mangfoldighed af hajer, hvaler, havskildpadder og sæler, mange flere end i dag. Blandt dem finder man Danmarks største fossiler som er udstillet på Museum Sønderjylland - Naturhistorie og Palæontologi i Gram.......For 8 millioner år siden myldrede Nordsøen af en mangfoldighed af hajer, hvaler, havskildpadder og sæler, mange flere end i dag. Blandt dem finder man Danmarks største fossiler som er udstillet på Museum Sønderjylland - Naturhistorie og Palæontologi i Gram....

  2. Building a St\\"uckelberg Portal

    CERN Document Server

    Feng, Wan-Zhe; Soler, Pablo; Ye, Fang

    2014-01-01

    We construct explicit string theory models realizing the recently proposed "St\\"uckelberg Portal" scenario, a framework for building Z' mediation models without the need to introduce unwanted exotic matter charged under the Standard Model. This scenario can be viewed purely field-theoretically, although it is particularly well motivated from string theory. By analyzing carefully the St\\"uckelberg couplings between the Abelian gauge bosons and the RR axions, we construct the first global intersecting brane models which extend the Standard Model with a genuine hidden sector, to which it is nonetheless connected via U(1) mass mixings. Utilizing the explicit models we construct, we discuss some broad phenomenological properties and experimental implications of this scenario such as Z-Z' mixings, dark matter stability and relic density, and supersymmetry mediation. With an appropriate confining hidden sector, our setup also provides a minimal realization of the hidden valley scenario. We further explore the possib...

  3. Selective Reproduction in the 21st Century

    DEFF Research Database (Denmark)

    In the 21st century, human reproduction increasingly involves decisions about which gametes to fertilize, which embryos to implant, or which fetuses to abort. The term ‘selective reproduction’ refers to these increasingly widespread efforts to bring specific kinds of children into being....... To this end, selective reproductive technologies (SRTs) have been developed and routinized over the last few decades. In today’s world, selective reproduction is taking place on a historically unprecedented scale; through sex-selective abortions following ultrasound scans, termination of pregnancies following...... detection of fetal anomalies during prenatal screening and testing programs, the development of preimplantation genetic diagnosis techniques as well as the screening of potential gamete donors by egg agencies and sperm banks. Selective Reproduction in the 21st Century provides unique ethnographic insights...

  4. Støtte til vedvarende energi?

    DEFF Research Database (Denmark)

    Skytte, K.; Jensen, Stine Grenaa; Morthorst, Poul Erik

    Udvikling af teknologier til fremstilling af elektricitet ved brug af vedvarende energiteknologier har i mange år haft høj prioritet i Danmark og modtaget betydelig støtte. Resultaterne har været meget blandede. For nogle teknologier som vindkraft har udviklingen været en succes, mens den for andre...... er gået mere trægt. Hvad er forklaringen på de meget forskellige erfaringer? Kan succesen gentages for andre teknologier blot ved at kopiere støtte- og rammebetingelserne fra vindkraft? Disse spørgsmål søges besvaret i bogen. Erfaringskurver og relevant innovationsteori gennemgås, og der opstilles en...

  5. Detergents of the 21st century

    Directory of Open Access Journals (Sweden)

    Ho Tan Tai Louis

    2001-03-01

    Full Text Available Detergents of the 21st century will depend on evolutions in household appliances, in substrates and in consumer needs. In addition, the environmental constraints, which become more and more stringent, will also play an important role, particularly in the formulations. Surfactants, which constitute one of the main raw materials in detergents, will have to be more environmentally friendly with increasing criteria of biodegradability and renewable materials. Builders (phosphates or zeolithes, heavy metal complexants (EDTA and bleaching agents (combination perborate/TAED are also expected to be replaced by biodegradable compounds, with better performances and lower costs. The real raw materials of the detergents of the 21st century will probably be enzymes (oxidase, hydrolase, peroxidase which present several advantages. At the same time, efforts will be made on biodegradable packaging through the use of micro-organisms able to degrade polymers. Finally, in terms of product forms, the concept of concentration might come back through the use of tablets.

  6. 78 FR 16211 - Safety Zone, Corp. Event Finale UHC, St. Thomas Harbor; St. Thomas, U.S. Virgin Islands

    Science.gov (United States)

    2013-03-14

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone, Corp. Event Finale UHC, St. Thomas Harbor... Harbor in St. Thomas, U.S. Virgin Islands during the Corp. Event Finale UHC firework display. The safety.... Event Finale UHC, ] a firework display. The event will be held on the waters of St. Thomas Harbor,...

  7. Baseline risk assessment for exposure to contaminants at the St. Louis Site, St. Louis, Missouri

    Energy Technology Data Exchange (ETDEWEB)

    1993-11-01

    The St. Louis Site comprises three noncontiguous areas in and near St. Louis, Missouri: the St. Louis Downtown Site (SLDS), the St. Louis Airport Storage Site (SLAPS), and the Latty Avenue Properties. The main site of the Latty Avenue Properties includes the Hazelwood Interim Storage Site (HISS) and the Futura Coatings property, which are located at 9200 Latty Avenue. Contamination at the St. Louis Site is the result of uranium processing and disposal activities that took place from the 1940s through the 1970s. Uranium processing took place at the SLDS from 1942 through 1957. From the 1940s through the 1960s, SLAPS was used as a storage area for residues from the manufacturing operations at SLDS. The materials stored at SLAPS were bought by Continental Mining and Milling Company of Chicago, Illinois, in 1966, and moved to the HISS/Futura Coatings property at 9200 Latty Avenue. Vicinity properties became contaminated as a result of transport and movement of the contaminated material among SLDS, SLAPS, and the 9200 Latty Avenue property. This contamination led to the SLAPS, HISS, and Futura Coatings properties being placed on the National Priorities List (NPL) of the US Environmental Protection Agency (EPA). The US Department of Energy (DOE) is responsible for cleanup activities at the St. Louis Site under its Formerly Utilized Sites Remedial Action Program (FUSRAP). The primary goal of FUSRAP is the elimination of potential hazards to human health and the environment at former Manhattan Engineer District/Atomic Energy Commission (MED/AEC) sites so that, to the extent possible, these properties can be released for use without restrictions. To determine and establish cleanup goals for the St. Louis Site, DOE is currently preparing a remedial investigation/feasibility study-environmental impact statement (RI/FS-EIS). This baseline risk assessment (BRA) is a component of the process; it addresses potential risk to human health and the environment associated wi

  8. Chick RGS2L demonstrates concentration-dependent selectivity for pertussis toxin-sensitive and -insensitive pathways that inhibit L-type Ca2+ channels.

    Science.gov (United States)

    Tosetti, Patrizia; Parente, Valeria; Taglietti, Vanni; Dunlap, Kathleen; Toselli, Mauro

    2003-05-15

    In neuronal cells, the influx of Ca2+ ions through voltage-dependent L-type calcium (L) channels couples excitation to multiple cellular functions. In addition to voltage, several neurotransmitters, hormones and cytokines regulate L channel gating via binding to G-protein-coupled receptors. Intracellular molecules that modify G-protein activity - such as regulator of G-protein-signalling (RGS) proteins - are therefore potential candidates for regulating Ca2+ influx through L channels. Here we show that a novel RGS2 splice variant from chick dorsal root ganglion (DRG) neurons, RGS2L, reduces bradykinin (BK)-mediated inhibition of neuronal L channels and accelerates recovery from inhibition. Chick RGS2 reduces the inhibition mediated by both the pertussis toxin (PTX)-sensitive (Gi/o-coupled) and the PTX-insensitive (presumably Gq/11-coupled) pathways. However, we demonstrate for the first time in a living cell that the extent of coupling to each pathway varies with RGS2L concentration. A low concentration of recombinant chick RGS2L (10 nM) preferentially reduces the inhibition mediated by the PTX-insensitive pathway, whereas a 100-fold higher concentration attenuates both PTX-sensitive- and PTX-insensitive-mediated components equally. Our data suggest that factors promoting RGS2L gene induction may regulate Ca2+ influx through L channels by recruiting low-affinity interactions with Gi/o that are absent at basal RGS2L levels.

  9. Pooling strategies for St Petersburg gamblers

    OpenAIRE

    Csörgö, Sandor; Simons, Gordon

    2006-01-01

    Peter offers to play exactly one St Petersburg game with each of [math] players, Paul [math] , [math] , Paul [math] , whose conceivable pooling strategies are described by all possible probability distributions [math] . Comparing infinite expectations, we characterize among all [math] those admissible strategies for which the pooled winnings, each distributed as [math] , yield a finite added value for each and every one of Paul [math] , [math] , Paul [math] in comparison with their individual...

  10. 2011 EFFoST Annual Meeting, Berlin

    OpenAIRE

    2012-01-01

    The 2011 European Federation of Food Science and Technology (EFFoST) conference took place in Berlin, Germany on 9-11 November. The conference programme centred on food process-structure-function relationships and the content was closely allied to the research agenda of the European Technology Platform: Food for Life. There were 16 keynote/review lectures, 38 other oral presentations, 260 posters, and close to 300 attendees. The oral sessions corresponded to the process-structure-function the...

  11. Pooling strategies for St Petersburg gamblers

    OpenAIRE

    Csörgö, Sandor; Simons, Gordon

    2006-01-01

    Peter offers to play exactly one St Petersburg game with each of [math] players, Paul [math] , [math] , Paul [math] , whose conceivable pooling strategies are described by all possible probability distributions [math] . Comparing infinite expectations, we characterize among all [math] those admissible strategies for which the pooled winnings, each distributed as [math] , yield a finite added value for each and every one of Paul [math] , [math] , Paul [math] in comparison with their individual...

  12. The Geological Environment West of St. Croix

    Science.gov (United States)

    1977-03-01

    determined to be late Cretaceous and younger. Fink, L.K., Jr. (1972). Bathymetric and Geologic Studies of the Guadeloupe Region, Lesser Antilles...Dominica through studies of the geology of the islands, particularly that of Guadeloupe and nearby submarine physiographic regions. The finding of Late...Living Birds of Puerto Rico. Jour, of Agriculture of the Union of Puerto Rico, v. 21, no. 1, p. 5-16. Whetten, J.R. (1961). Geology of St. Croix, U.S

  13. Facilitating access to vegetation data – Introduction to the Special Volume

    NARCIS (Netherlands)

    Dengler, J.; Oldeland, J.; Jansen, F.; Schaminee, J.H.J.

    2012-01-01

    This editorial introduces the Special Volume “Vegetation databases for the 21st century”, which is an outcome of the 9th Meeting on Vegetation Databases, held 24–26 February 2010 in Hamburg. We briefly report on the meeting with its presentations and workshops. Then we highlight the launch of the

  14. Education in One World: Perspectives from Different Nations. BCES Conference Books, Volume 11

    Science.gov (United States)

    Popov, Nikolay, Ed.; Wolhuter, Charl, Ed.; Almeida, Patrícia Albergaria, Ed.; Hilton, Gillian, Ed.; Ogunleye, James, Ed.; Chigisheva, Oksana, Ed.

    2013-01-01

    This volume contains papers submitted to the 11th Annual International Conference of the Bulgarian Comparative Education Society (BCES), held in Plovdiv, Bulgaria, 14-17 May 2013, and papers submitted to the 1st International Distance Partner Conference, organized by the International Research Centre "Scientific Cooperation,"…

  15. Zdravotní středisko

    OpenAIRE

    Fukanová, Lenka

    2016-01-01

    Projekt mé diplomové práce je novostavba zdravotního střediska. Jedná se o samostatně stojící budovu, která je situovaná na mírně svažitém terénu, který bude vyrovnán. Objekt je částečně podsklepený a má dvě nadzemní podlaží. V podzemním podlaží se nachází technické zázemí střediska. V prvním nadzemním podlaží je umístěna recepce, čekárna, sesterny, ordinace a lékárna. V druhém nadzemním podlaží jsou opět čekárny, sesterny, ordinace a cvičební sál. K objektu přiléhá parkoviště. Budova je zděn...

  16. Carl Størmer Auroral Pioneer

    CERN Document Server

    Egeland, Alv

    2013-01-01

    This biography summarizes the seminal contributions to auroral and space science of Carl Størmer (1874 - 1957). He was the first to develop precise photographic methods to calculate heights and morphologies of diverse auroral forms during four solar cycles. Størmer independently devised numerical techniques to determine the trajectories of high-energy charged particles allowed and forbidden in the Earth’s magnetic field. His theoretical analyses explained cosmic ray access to the upper atmosphere, 20 years before they were identified by other scientists. Størmer’s crowning achievement, “The Polar Aurora,” published when he was 81 years old, stands to this day as a regularly cited guide in graduate-level courses on space physics.   The authors present the life of this prodigious scientist in relation to the cultural life of early 20th century in Norway and to the development of the space sciences in the post-Sputnik era.

  17. Caldendrin, a neuron-specific modulator of Cav/1.2 (L-type) Ca2+ channels.

    Science.gov (United States)

    Tippens, Alyssa L; Lee, Amy

    2007-03-16

    EF-hand Ca2+-binding proteins such as calmodulin and CaBP1 have emerged as important regulatory subunits of voltage-gated Ca2+ channels. Here, we show that caldendrin, a variant of CaBP1 enriched in the brain, interacts with and distinctly modulates Cav1.2 (L-type) voltage-gated Ca2+ channels relative to other Ca2+-binding proteins. Caldendrin binds to the C-terminal IQ-domain of the pore-forming alpha1-subunit of Cav1.2 (alpha(1)1.2) and competitively displaces calmodulin and CaBP1 from this site. Compared with CaBP1, caldendrin causes a more modest suppression of Ca2+-dependent inactivation of Cav1.2 through a different subset of molecular determinants. Caldendrin does not bind to the N-terminal domain of alpha11.2, a site that is critical for functional interactions of the channel with CaBP1. Deletion of the N-terminal domain inhibits CaBP1, but spares caldendrin modulation of Cav1.2 inactivation. In contrast, mutations of the IQ-domain abolish physical and functional interactions of caldendrin and Cav1.2, but do not prevent channel modulation by CaBP1. Using antibodies specific for caldendrin and Cav1.2, we show that caldendrin coimmunoprecipitates with Cav1.2 from the brain and colocalizes with Cav1.2 in somatodendritic puncta of cortical neurons in culture. Our findings reveal functional diversity within related Ca2+-binding proteins, which may enhance the specificity of Ca2+ signaling by Cav1.2 channels in different cellular contexts.

  18. Volume regulation in epithelia

    DEFF Research Database (Denmark)

    Larsen, Erik Hviid; Hoffmann, Else Kay

    2016-01-01

    function of iso-osmotic fluid transport that depends on Na+ recirculation. The causative relationship is discussed for a fluid-absorbing and a fluid-secreting epithelium of which the Na+ recirculation mechanisms have been identified. A large number of transporters and ion channels involved in cell volume...... regulation are cloned. The volume-regulated anion channel (VRAC) exhibiting specific electrophysiological characteristics seems exclusive to serve cell volume regulation. This is contrary to K+ channels as well as cotransporters and exchange mechanisms that may serve both transepithelial transport and cell...

  19. Towards the Amplituhedron Volume

    CERN Document Server

    Ferro, Livia; Orta, Andrea; Parisi, Matteo

    2015-01-01

    It has been recently conjectured that scattering amplitudes in planar N=4 super Yang-Mills are given by the volume of the (dual) amplituhedron. In this paper we show some interesting connections between the tree-level amplituhedron and a special class of differential equations. In particular we demonstrate how the amplituhedron volume for NMHV amplitudes is determined by these differential equations. The new formulation allows for a straightforward geometric description, without any reference to triangulations. Finally we discuss possible implications for volumes related to generic N^kMHV amplitudes.

  20. Unsteady flow volumes

    Energy Technology Data Exchange (ETDEWEB)

    Becker, B.G.; Lane, D.A.; Max, N.L.

    1995-03-01

    Flow volumes are extended for use in unsteady (time-dependent) flows. The resulting unsteady flow volumes are the 3 dimensional analog of streamlines. There are few examples where methods other than particle tracing have been used to visualize time varying flows. Since particle paths can become convoluted in time there are additional considerations to be made when extending any visualization technique to unsteady flows. We will present some solutions to the problems which occur in subdivision, rendering, and system design. We will apply the unsteady flow volumes to a variety of field types including moving multi-zoned curvilinear grids.

  1. Bronchoscopic lung volume reduction

    Directory of Open Access Journals (Sweden)

    M. I. Polkey

    2006-12-01

    Full Text Available Surgical lung volume reduction can improve exercise performance and forced expiratory volume in one second in patients with emphysema. However, the procedure is associated with a 5% mortality rate and a nonresponse rate of 25%. Accordingly, interest has focused on alternative ways of reducing lung volume. Two principle approaches are used: collapse of the diseased area using blockers placed endobronchially and the creation of extrapulmonary pathways. Preliminary data from the former approach suggest that it can be successful and that the magnitude of success is related to reduction in dynamic hyperinflation.

  2. Volume morphology of printable solar cells

    Directory of Open Access Journals (Sweden)

    Joachim Loos

    2010-10-01

    Full Text Available Printable polymer or hybrid solar cells (PSCs have the potential to become one of the leading technologies of the 21st century in conversion of sunlight to electrical energy. Because of their ease of processing from solution fast and low cost mass production of devices is possible in a roll-to-roll printing fashion. The performance of such printed devices, in turn, is determined to a large extent by the three-dimensional organization of the photoactive layer, i.e. layer where light is absorbed and converted into free electrical charges, and its contacts with the charge collecting electrodes. In this review I briefly introduce our current understanding of morphology-performance relationships in PSCs with specific focus on electron tomography as analytical tool providing volume information with nanometer resolution.

  3. The Impact of Technological Change on Military Manpower in the 21st Century

    Science.gov (United States)

    1990-06-01

    11ners. flat data bases volume. equity operatuial planning "TIhe Federaiin" h,--h r-,hn I her’stchial, Man s.imiar A,, uilgarchv Duplicated opera!ing... foot soldier who will continue to be the key to future combat operations. In addition Wickham emph sed the importance of command, control...G.J., "Moving C3 Into the 21st Century," Signal, pp. 91-94, August 1989. Mannle, T.E., and Risser , D.T., Estimating the Manpower, Personnel, and

  4. Foreign and Russian legal psychology: meeting in St. Petersburg

    Directory of Open Access Journals (Sweden)

    Dozortseva E.G.

    2016-01-01

    Full Text Available 24 - 27 June 2014 in St. Petersburg state University hosted the conference of the European Association of Psychology and Law (EAPL "Actual problems of legal psychology. Victims and witnesses: from research to effective practice". The conference was attended by over 330 professionals from 24 countries, making it the largest international forum on legal psychology in Russia. Special symposia were dedicated to an outstanding scientist working in the field of forensic psychology in the Netherlands and Russia, - V. A. Wagenaar and M. M. Kochenova. 42 thematic sessions presentations were made, covering all areas of legal psychology. For the first time foreign colleagues and national experts had the opportunity to get acquainted with the issues and each other's experiences in this volume. Great attention was paid to the issues of memory, true and false memories, lie detection, of investigation of serial crimes. A feature of the conference was the active participation not only of psychologists but also of lawyers, who presented his view of psychological problems in a legal context. Currently is working on a book, a collection of papers following the conference.

  5. Regionalization of ST-segment elevation acute coronary syndromes care: putting a national policy in proper perspective.

    Science.gov (United States)

    Rathore, Saif S; Epstein, Andrew J; Nallamothu, Brahmajee K; Krumholz, Harlan M

    2006-04-04

    A uniform policy for regionalization of ST-segment elevation myocardial infarction (STEMI) care raises several concerns. Transferring all STEMI patients to obtain primary percutaneous coronary intervention (PCI) may be less effective than transferring only high-risk STEMI patients. Delays in time to treatment >60 min associated with transferring patients for primary PCI may result in increased mortality for the average patient as compared with providing immediate fibrinolytic therapy at their initial hospital; yet more than 95% of patients transferred for primary PCI in the U.S. exceed this 60-min benchmark. Superior outcomes associated with treatment at higher-volume regional STEMI centers are inconsistent among centers, and there is no direct evidence that patients will benefit by a transfer to a high-volume hospital from a low-volume hospital. Published data suggest as many as 800 PCI patients would need to be transferred to a high-volume PCI hospital to avoid a single death at a low-volume PCI hospital. Although European randomized trial data suggest transferring patients with STEMI for primary PCI may be superior to immediate fibrinolytic therapy, these findings are unlikely to generalize to the U.S. health care system given size, geography, and organization. ST segment elevation myocardial infarction care regionalization would require a massive redistribution of health care resources, depriving several hospitals of advanced cardiac care facilities, expertise, and associated revenue. Clearer evidence of the benefits and discussion of potential harms are needed before adopting a national STEMI regionalization policy.

  6. 30 Cool Facts about Mount St. Helens

    Science.gov (United States)

    Driedger, Carolyn; Liz, Westby; Faust, Lisa; Frenzen, Peter; Bennett, Jeanne; Clynne, Michael

    2010-01-01

    Commemorating the 30th anniversary of the 1980 eruptions of Mount St. Helens 1-During the past 4,000 years, Mount St. Helens has erupted more frequently than any other volcano in the Cascade Range. 2-Most of Mount St. Helens is younger than 3,000 years old (younger than the pyramids of Egypt). 3-Some Native American names that refer to smoke at the volcano include- Lawala Clough, Low-We- Lat-Klah, Low-We-Not- Thlat, Loowit, Loo-wit, Loo-wit Lat-kla, and Louwala-Clough. 4-3,600 years ago-Native Americans abandoned hunting grounds devastated by an enormous eruption four times larger than the May 18, 1980 eruption. 5-1792-Captain George Vancouver named the volcano for Britain's ambassador to Spain, Alleyne Fitzherbert, also known as Baron St. Helens. 6-1975-U.S. Geological Survey geologists forecasted that Mount St. Helens would erupt again, 'possibly before the end of the century.' 7-March 20, 1980-A magnitude 4.2 earthquake signaled the reawakening of the volcano after 123 years. 8-Spring 1980-Rising magma pushed the volcano's north flank outward 5 feet per day. 9-Morning of May 18, 1980- The largest terrestrial landslide in recorded history reduced the summit by 1,300 feet and triggered a lateral blast. 10-Within 3 minutes, the lateral blast, traveling at more than 300 miles per hour, blew down and scorched 230 square miles of forest. 11-Within 15 minutes, a vertical plume of volcanic ash rose over 80,000 feet. 12-Afternoon of May 18, 1980-The dense ash cloud turned daylight into darkness in eastern Washington, causing streetlights to turn on in Yakima and Ritzville. 13-The volcanic ash cloud drifted east across the United States in 3 days and encircled Earth in 15 days. 14-Lahars (volcanic mudflows) filled rivers with rocks, sand, and mud, damaging 27 bridges and 200 homes and forcing 31 ships to remain in ports upstream. 15-The May 18, 1980 eruption was the most economically destructive volcanic event in U.S. history. 16-Small plants and trees beneath winter snow

  7. Free volume under shear

    Science.gov (United States)

    Maiti, Moumita; Vinutha, H. A.; Sastry, Srikanth; Heussinger, Claus

    2015-10-01

    Using an athermal quasistatic simulation protocol, we study the distribution of free volumes in sheared hard-particle packings close to, but below, the random-close packing threshold. We show that under shear, and independent of volume fraction, the free volumes develop features similar to close-packed systems — particles self-organize in a manner as to mimick the isotropically jammed state. We compare athermally sheared packings with thermalized packings and show that thermalization leads to an erasure of these structural features. The temporal evolution in particular the opening-up and the closing of free-volume patches is associated with the single-particle dynamics, showing a crossover from ballistic to diffusive behavior.

  8. Integers annual volume 2013

    CERN Document Server

    Landman, Bruce

    2014-01-01

    ""Integers"" is a refereed online journal devoted to research in the area of combinatorial number theory. It publishes original research articles in combinatorics and number theory. This work presents all papers of the 2013 volume in book form.

  9. Renormalized Volumes with Boundary

    CERN Document Server

    Gover, A Rod

    2016-01-01

    We develop a general regulated volume expansion for the volume of a manifold with boundary whose measure is suitably singular along a separating hypersurface. The expansion is shown to have a regulator independent anomaly term and a renormalized volume term given by the primitive of an associated anomaly operator. These results apply to a wide range of structures. We detail applications in the setting of measures derived from a conformally singular metric. In particular, we show that the anomaly generates invariant (Q-curvature, transgression)-type pairs for hypersurfaces with boundary. For the special case of anomalies coming from the volume enclosed by a minimal hypersurface ending on the boundary of a Poincare--Einstein structure, this result recovers Branson's Q-curvature and corresponding transgression. When the singular metric solves a boundary version of the constant scalar curvature Yamabe problem, the anomaly gives generalized Willmore energy functionals for hypersurfaces with boundary. Our approach ...

  10. Environmental chemistry: Volume A

    Energy Technology Data Exchange (ETDEWEB)

    Yen, T.F.

    1999-08-01

    This is an extensive introduction to environmental chemistry for engineering and chemical professionals. The contents of Volume A include a brief review of basic chemistry prior to coverage of litho, atmo, hydro, pedo, and biospheres.

  11. Cultural Resources Survey and Testing for Davis Pond Freshwater Diversion, St. Charles Parish, Louisiana. Volume 2

    Science.gov (United States)

    1994-05-01

    samples analyzed. Cyperaceae ( sedge family) cone-shape forms were also 0 identified in the 16SC27 samples. Although morphologically similar forms may be...ethnobotanical resources. For example, both grass (Poaceae) and sedge ( Cyperaceae ) phytolith types represent potential botanical resources. However, the...produced by other plants, these conical forms on flat, polygonal bases are most commonly produced by sedges . These forms occur in all but one sample

  12. Mount St. Helens, Washington Feasibility Report & Environmental Impact Statement. Volume 1: Main Report

    Science.gov (United States)

    1984-12-01

    bracken fern, Oregon grape, fireweed, pearly everlasting, thimbleberry and false dandelion (in decreasing order) had the greatest relative frequencies in...Green River. WDF and Weyerhaeuser have already initiated revegetation of Elk Creek, another Green River tributary, with flowering dogwood, wild rose

  13. Air & Space Power Journal (ASPJ) - Africa and Francophonie. Volume 4, Number 1. 1st Quarter 2013

    Science.gov (United States)

    2013-01-01

    the state to compel the Roman Catholic Church, Greek Orthodox Church, Orthodox Judaism, and others to ordain women as priests or as part of their...Buddhist communities. Find comfort in speak- ing the language of your cultural extraction, whether Afrikaans, English, Greek , Portuguese, Tswana, Xhosa...of Muslims.”73 A newspaper report that likens homosexuality to bestiality cannot be tolerated under freedom of the press because it pro- motes hatred

  14. Great Lakes and St. Lawrence Seaway Navigation Season Extension. Volume 4. Appendixes D - F

    Science.gov (United States)

    1979-08-01

    Hw4k H 4.41 41 EnN~ HHs~C. 0 za a% a. 1 - nr a% N C)0 0 N O C4)j-It q~ H1 H H- 0 ’i.’III; 4); 1 C; Q. L; .r cn ~~ r- N0 "H 0 Z0 COLA r-’TM14 P-1...41 CA Z ~ ~ Cu COCA ’ 04 0 w 0 1110 04 0 0) Cu 0) 0% C 64 -4 N4 L -44 O (I> A- WA E--3 0% LA in r’. 001 -4 0 InI LA - N .4 r- 00 co .4 -4 CI 00 cc -4...the site location. Winter for many birds and terrestrial mammals is a critical period. Metabolic demands created by low temperatures, winds, and

  15. Cultural Resources Inventory of the Montz Freshwater Diversion Project Corridor, St. Charles Parish, Louisiana. Volume 1.

    Science.gov (United States)

    1986-06-23

    Ulmus) , and pecan ( Carya illinoensis ) may occur at higher elevations, Predominant understory vegetation includes poison ivy, grape and trumpet...suggests that the trees surrounding the cemetery were not planted; all of the species identified, including pecan trees ( Carya illinoensis ), occur

  16. Proceedings of Military Operations Research Symposia (Index) Volume 3. 31st through 40th inclusive

    Science.gov (United States)

    1980-11-01

    aid- ing in tactical operations, 38-280 Erler Robert J! (with GD talushynsky and llV Wilson), Point defense requirements model: methodology and Frieder...CONUS eir defense. 34-34 pote Address. 33rd MiORS). 3f3-3 lialushynsky George D (with RII Erler and IJY Wilson). loltrv A (with C Andersen and R...301 40-188 i °A Washburn Allen R, Some thoughts on the changing Wilson Harold V (with RH Erler and ui Halushynsky), environment for cost-effectiveness

  17. Cultural Resources Survey and Testing for Davis Pond Freshwater Diversion, St. Charles Parish, Louisiana. Volume 1

    Science.gov (United States)

    1994-05-01

    virginiana, Q. alba, Q. nigra), shagbark hickory (Carya ovata), hackberry (Celtis laevigata ), sweetgum (Liquidambar styaciflua), pecan (Carya illinoiensis...Subdominants include the sweet gum (Liquidambar stryaciflua), hackberry (Celtis laevigata ), and live oak (Quercus virginiana). Other forest species...common shrub species are palmetto (Sabal minor) and green haw ( Crataegus viridis), but thickets of possum-haw (Ilex decidua) also occur. Within

  18. New World Vistas: Air and Space Power for the 21st Century, Materials Volume.

    Science.gov (United States)

    1996-06-01

    cyclodextrine nitrate, and HTREL, plus new oxidizers such as ADN that are currently available, and the developing area of high nitrogen compounds that have... encapsulation , bondline venting of off-gases, microthin injectors, microcombustion chambers, and solar absorbing heat exchangers. Figure 12.3 shows a...structures through molecular encapsulation need to be investigated, and this is where nanophased polymers of the nanoparticle type may play an

  19. Leading Edge. Sensors Challenges and Solutions for the 21st Century. Volume 7, Issue Number 2

    Science.gov (United States)

    2010-01-01

    Radar Architecture (ACRA) Program components include the radar array’s mechani - cal structure and electrical signal network, digital receivers...detection band out to at least 11 µ is required. Cooled LWIR cameras tend to have detector arrays of two types: quantum well infrared photo- detector... quantum in- crease in adaptive nulling, clutter rejection, and sidelobe cancellation capability over current U.S. analog-based radars. • The program’s

  20. The DTIC Review: Volume 2. Number 2, Future Directions - Preparing for the 21st Century

    Science.gov (United States)

    1996-07-01

    War College. His most recent SSI study is Deciphering the Balkan Enigma : Using History to Inform Policy (revised edition). DOUGLAS V. JOHNSON II is an...where they are to be used without landing the transport aircraft. Delivery of medical supplies beside the hospitals, food directly to the soldier or...mindedness of the French at Dien Bien Phu or the short-sightedness of Hitler in Operation Barbarossa--failures which underscore the criticality of

  1. Cultural Resources Inventory of the Montz Freshwater Diversion Project Corridor, St. Charles Parish, Louisiana. Volume 2.

    Science.gov (United States)

    1986-06-23

    irdtrial ) vernmental ) gricultural )other Historic structures (dependencies) present on the m site: )store ( kitd ) quarters ) garcoierre ) office c...commercial ( ) indtrial ( ) governmental S ) gricultural ( ) other Historic structures (dependencies) present on the same site: ( ) store kitdcn ( ) quarters

  2. Great Lakes and St. Lawrence Seaway Navigation Season Extension. Volume 6. Appendixes H - L

    Science.gov (United States)

    1979-08-01

    dissemination to affected personnel, for the use of volunteers where possible, and for more personnel involvement and feedback . More summer vacation time...effective-% used in lock gale machiner. recesses to present ice btudiup. Air- hubrler ines along the lock floor chamber have been efle ::ise in

  3. Generalized Partial Volume

    DEFF Research Database (Denmark)

    Darkner, Sune; Sporring, Jon

    2011-01-01

    Mutual Information (MI) and normalized mutual information (NMI) are popular choices as similarity measure for multimodal image registration. Presently, one of two approaches is often used for estimating these measures: The Parzen Window (PW) and the Generalized Partial Volume (GPV). Their theoret......Mutual Information (MI) and normalized mutual information (NMI) are popular choices as similarity measure for multimodal image registration. Presently, one of two approaches is often used for estimating these measures: The Parzen Window (PW) and the Generalized Partial Volume (GPV...

  4. rno-miR-665 targets BCL2L1 (Bcl-xl) and increases vulnerability to propofol in developing astrocytes.

    Science.gov (United States)

    Sun, Wen-Chong; Pei, Ling

    2016-07-01

    Propofol exerts a cytotoxic influence over immature neurocytes. Our previous study revealed that clinically relevant doses of propofol accelerated apoptosis of primary cultured astrocytes of developing rodent brains via rno-miR-665 regulation. However, the role of rno-miR-665 during the growth spurt of neonatal rodent brains in vivo is still uncertain. Post-natal day 7 (P7) rats received a single injection of propofol 30 mg/kg intraperitoneally (i.p.), and neuroapoptosis of hippocampal astrocytes was analyzed by immunofluorescence and scanning electron microscopy. The differential expression of rno-miR-665, BCL2L1 (Bcl-xl), and cleaved caspase 3 (CC3) was surveyed by qRT-PCR and western blotting. In addition, the utility of A-1155463, a highly potent and BCL2L1-selective antagonist, was aimed to assess the contribution of BCL2L1 for neuroglial survival. Following the intraventricular injection of lentivirus rno-miR-665, neuroprotection was detected by 5-point scale measurement. The single dose of propofol 30 mg/kg triggered dose-dependent apoptosis of developing hippocampal astrocytes. Meanwhile, propofol triggered both rno-miR-665 and CC3, and depressed BCL2L1, which was predicted as one target gene of rno-miR-665. Combination treatment with A-1155463 and propofol induced lower mRNA and protein levels of BCL2L1 and more CC3 activation than propofol treatment alone in vivo. The lentivirus-mediated knockdown of rno-miR-665 elevated BCL2L1 and attenuated CC3 levels, whereas up-regulation of rno-miR-665 suppressed BCL2L1 and induced CC3 expression in vivo. More importantly, rno-miR-665 antagomir infusion improved neurological outcomes of pups receiving propofol during the brain growth spurt. Rno-miR-665, providing a potential target for alternative therapeutics for pediatric anesthesia, is susceptible to propofol by negatively targeting antiapoptotic BCL2L1. Relatively little is known about the association between exposure of astrocytes to brief propofol

  5. Investigation of spinal cerebrospinal fluid-contacting neurons expressing PKD2L1: evidence for a conserved system from fish to primates

    Directory of Open Access Journals (Sweden)

    Lydia eDjenoune

    2014-05-01

    Full Text Available Over ninety years ago, Kolmer and Agduhr identified spinal cerebrospinal fluid-contacting neurons (CSF-cNs based on their morphology and location within the spinal cord. In more than two hundred vertebrate species, they observed ciliated neurons around the central canal that extended a brush of microvilli into the cerebrospinal fluid (CSF. Although their morphology is suggestive of a primitive sensory cell, their function within the vertebrate spinal cord remains unknown. The identification of specific molecular markers for these neurons in vertebrates would benefit the investigation of their physiological roles. PKD2L1, a transient receptor potential channel that could play a role as a sensory receptor, has been found in cells contacting the central canal in mouse. In this study, we demonstrate that PKD2L1 is a specific marker for CSF-cNs in the spinal cord of mouse (Mus musculus, macaque (Macaca fascicularis and zebrafish (Danio rerio. In these species, the somata of spinal PKD2L1+ CSF-cNs were located below or within the ependymal layer and extended an apical bulbous extension into the central canal. We found GABAergic PKD2L1-expressing CSF-cNs in all three species. We took advantage of the zebrafish embryo for its transparency and rapid development to identify the progenitor domains from which pkd2l1+ CSF-cNs originate. pkd2l1+ CSF-cNs were all GABAergic and organized in two rows—one ventral and one dorsal to the central canal. Their location and marker expression is consistent with previously described Kolmer-Agduhr cells. Accordingly, pkd2l1+ CSF-cNs were derived from the progenitor domains p3 and pMN defined by the expression of nkx2.2a and olig2 transcription factors, respectively. Altogether our results suggest that a system of CSF-cNs expressing the PKD2L1 channel is conserved in the spinal cord across bony vertebrate species.

  6. Investigation of spinal cerebrospinal fluid-contacting neurons expressing PKD2L1: evidence for a conserved system from fish to primates.

    Science.gov (United States)

    Djenoune, Lydia; Khabou, Hanen; Joubert, Fanny; Quan, Feng B; Nunes Figueiredo, Sophie; Bodineau, Laurence; Del Bene, Filippo; Burcklé, Céline; Tostivint, Hervé; Wyart, Claire

    2014-01-01

    Over 90 years ago, Kolmer and Agduhr identified spinal cerebrospinal fluid-contacting neurons (CSF-cNs) based on their morphology and location within the spinal cord. In more than 200 vertebrate species, they observed ciliated neurons around the central canal that extended a brush of microvilli into the cerebrospinal fluid (CSF). Although their morphology is suggestive of a primitive sensory cell, their function within the vertebrate spinal cord remains unknown. The identification of specific molecular markers for these neurons in vertebrates would benefit the investigation of their physiological roles. PKD2L1, a transient receptor potential channel that could play a role as a sensory receptor, has been found in cells contacting the central canal in mouse. In this study, we demonstrate that PKD2L1 is a specific marker for CSF-cNs in the spinal cord of mouse (Mus musculus), macaque (Macaca fascicularis) and zebrafish (Danio rerio). In these species, the somata of spinal PKD2L1(+) CSF-cNs were located below or within the ependymal layer and extended an apical bulbous extension into the central canal. We found GABAergic PKD2L1-expressing CSF-cNs in all three species. We took advantage of the zebrafish embryo for its transparency and rapid development to identify the progenitor domains from which pkd2l1 (+) CSF-cNs originate. pkd2l1 (+) CSF-cNs were all GABAergic and organized in two rows-one ventral and one dorsal to the central canal. Their location and marker expression is consistent with previously described Kolmer-Agduhr cells. Accordingly, pkd2l1 (+) CSF-cNs were derived from the progenitor domains p3 and pMN defined by the expression of nkx2.2a and olig2 transcription factors, respectively. Altogether our results suggest that a system of CSF-cNs expressing the PKD2L1 channel is conserved in the spinal cord across bony vertebrate species.

  7. Reachable volume RRT

    KAUST Repository

    McMahon, Troy

    2015-05-01

    © 2015 IEEE. Reachable volumes are a new technique that allows one to efficiently restrict sampling to feasible/reachable regions of the planning space even for high degree of freedom and highly constrained problems. However, they have so far only been applied to graph-based sampling-based planners. In this paper we develop the methodology to apply reachable volumes to tree-based planners such as Rapidly-Exploring Random Trees (RRTs). In particular, we propose a reachable volume RRT called RVRRT that can solve high degree of freedom problems and problems with constraints. To do so, we develop a reachable volume stepping function, a reachable volume expand function, and a distance metric based on these operations. We also present a reachable volume local planner to ensure that local paths satisfy constraints for methods such as PRMs. We show experimentally that RVRRTs can solve constrained problems with as many as 64 degrees of freedom and unconstrained problems with as many as 134 degrees of freedom. RVRRTs can solve problems more efficiently than existing methods, requiring fewer nodes and collision detection calls. We also show that it is capable of solving difficult problems that existing methods cannot.

  8. Von der Melkmaschine St. Pauli zu Utopia? St. Pauli selber machen!

    Directory of Open Access Journals (Sweden)

    Steffen Jörg

    2014-05-01

    Full Text Available Das Interview mit Steffen Jörg vom Verein GWA (Gemeinwesenarbeit St. Pauli befasst sich mit den aktuellen Veränderungen in Hamburg St. Pauli. Es stellt sie in den Kontext der ,unternehmerischen Stadt’, die bereits seit den 1980er Jahren als Modell der Hamburger Stadtentwicklung gilt. Am Beispiel der kollektiven Proteste von Mieter_innen der inzwischen polizeilich geräumten ESSO-Häuser am Spielbudenplatz zeichnet Steffen Jörg das Bild von St. Pauli als einem umkämpften, aber auch widerspenstigen Stadtteil: Die Bewohner_innen artikulieren und organisieren sich immer deutlicher gegen die Vermarktung des Viertels und gegen eine eindimensional renditeorientierte Stadtentwicklung für Besserverdienende, mit der eine Verdrängung armer Mieter_innen und Kleingewerbestrukturen verbunden ist. 

  9. The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis.

    Science.gov (United States)

    Castillo, Ana F; Orlando, Ulises; Helfenberger, Katia E; Poderoso, Cecilia; Podesta, Ernesto J

    2015-06-15

    The steroidogenic acute regulatory (StAR) protein regulates the rate-limiting step in steroidogenesis, i.e. the delivery of cholesterol from the outer (OMM) to the inner (IMM) mitochondrial membrane. StAR is a 37-kDa protein with an N-terminal mitochondrial targeting sequence that is cleaved off during mitochondrial import to yield 30-kDa intramitochondrial StAR. StAR acts exclusively on the OMM and its activity is proportional to how long it remains on the OMM. However, the precise fashion and the molecular mechanism in which StAR remains on the OMM have not been elucidated yet. In this work we will discuss the role of mitochondrial fusion and StAR phosphorylation by the extracellular signal-regulated kinases 1/2 (ERK1/2) as part of the mechanism that regulates StAR retention on the OMM and activity.

  10. Co-ordination of a new bis-terpyridine ligand with cupric perchlorate yielding a dinuclear M 2L species

    Science.gov (United States)

    Knight, James C.; Prabaharan, Ravi; Edwards, Peter G.; Amoroso, Angelo J.

    2011-03-01

    We report the synthesis of a new bis-terpyridine ligand which could potentially yield a variety of polynuclear complexes. An investigation of the co-ordination chemistry of this ligand with Cu(II) ions in a 1:1 ratio yielded a complex with a 2:1 ratio of Cu to ligand. The crystal structure of the dinuclear copper(II) complex shows the two equivalent copper cations are co-ordinated via five donor atoms in a highly distorted square pyramidal arrangement. The structure was solved in a monoclinic space group C2/c with cell parameters, a = 21.340(5), b = 14.004(5), c = 18.368(5) Å, α = 90°, β = 106.575(5)°, γ = 90°, volume = 5261(3) Å 3, Z = 4.

  11. Mount St. Helens, 1980 to now—what’s going on?

    Science.gov (United States)

    Dzurisin, Daniel; Driedger, Carolyn L.; Faust, Lisa M.

    2013-01-01

    Mount St. Helens seized the world’s attention in 1980 when the largest historical landslide on Earth and a powerful explosive eruption reshaped the volcano, created its distinctive crater, and dramatically modified the surrounding landscape. An enormous lava dome grew episodically in the crater until 1986, when the volcano became relatively quiet. A new glacier grew in the crater, wrapping around and partly burying the lava dome. From 1987 to 2003, sporadic earthquake swarms and small steam explosions indicated that magma (molten rock) was being replenished deep underground. In 2004, steam-and-ash explosions heralded the start of another eruption. A quieter phase of continuous lava extrusion followed and lasted until 2008, building a new dome and doubling the volume of lava on the crater floor. Scientists with the U.S. Geological Survey and University of Washington’s Pacific Northwest Seismograph Network maintain constant watch for signs of renewed activity at Mount St. Helens and other Cascade volcanoes. Now is an ideal time for both actual and virtual visitors to Mount St. Helens to learn more about dramatic changes taking place on and beneath this active volcano.

  12. ST Elevation Myocardial Infarction in the elderly

    Institute of Scientific and Technical Information of China (English)

    Marcelo Franken; Amit Nussbacher; Alberto Liberman; Mauricio Wajngarten

    2012-01-01

    Acute coronary syndromes (ACS) are the leading causes of death in the elderly. The suspicion and diagnosis of ACS in this age group is more difficult, since typical angina is less frequent. The morbidity and mortality is greater in older age patients presenting ACS. Despite the higher prevalence and greater risk, elderly patients are underrepresented in major clinical trials from which evidence based recommendations are formulated. The authors describe, in this article, the challenges in the diagnosis and management of ST elevation myocardial infarction in the elderly, and discuss the available evidence.

  13. 21st Century South African Science Fiction

    Directory of Open Access Journals (Sweden)

    CARAIVAN LUIZA

    2014-12-01

    Full Text Available The paper analyses some aspects of South African science fiction, starting with its beginnings in the 1920s and focusing on some 21st century writings. Thus Lauren Beukes’ novels Moxyland (2008 and Zoo City (2010 are taken into consideration in order to present new trends in South African literature and the way science fiction has been marked by Apartheid. The second South African science fiction writer whose writings are examined is Henrietta Rose-Innes (with her novel Nineveh, published in 2011 as this consolidates women's presence in the SF world.

  14. Plan de negocios del proyecto "ST. Marcus"

    OpenAIRE

    Yépez Hidalgo, Patricia Alejandra

    2015-01-01

    The present work is a Business Plan Project "ST. Marcus ", located in the Valley of Cumbayá, in the La Primavera, consists of 112 apartments, consisting of suites and apartments of 2 and 3 bedrooms, four 6-story towers. It features spacious communal areas, gardens, pool, terraces, equipped gymnasium, squash court, meeting rooms, hotel lobby kind of luxury. Constructum S.A. a company with 20 year’s experience in real estate projects intends to invest in this project for profitability for th...

  15. Health Physics in the 21st Century

    CERN Document Server

    Bevelacqua, Joseph John

    2008-01-01

    Adopting a proactive approach and focusing on emerging radiation-generating technologies, Health Physics in the 21st Century meets the growing need for a presentation of the relevant radiological characteristics and hazards. As such, this monograph discusses those technologies that will affect the health physics and radiation protection profession over the decades to come. After an introductory overview, the second part of this book looks at fission and fusion energy, followed by a section devoted to accelerators, while the final main section deals with radiation on manned space missions.

  16. ST-elevations-myokardieinfarkt efter terapeutisk adrenalininjektion

    DEFF Research Database (Denmark)

    Rømhild Davidsen, Jesper; Lambrechtsen, Jess; Egstrup, Kenneth

    2006-01-01

    A case of acute myocardial infarction (AMI) following accidental iatrogenic overdose by adrenaline injection is described in a male aged 55 years. This patient was given 1 mg of adrenaline due to anaphylactic symptoms. Afterwards he presented with angina pectoris, dyspnoea and ST-segment elevation...... in the ECG. Plasma TnT and CK-MB were raised. A coronary angiography revealed a 66% stenosis of RCA. This patient had an asymptomatic RCA stenosis that probably became symptomatic due to coronary artery spasm related to adrenaline injection and thereby presented symptoms and signs of AMI....

  17. Water resources of St. Helena Parish, Louisiana

    Science.gov (United States)

    White, Vincent E.; Prakken, Lawrence B.

    2016-07-27

    Information concerning the availability, use, and quality of water in St. Helena Parish, Louisiana, is critical for proper water-resource management. The purpose of this fact sheet is to present information that can be used by water managers, parish residents, and others for stewardship of this vital resource. Information on the availability, past and current use, use trends, and water quality from groundwater and surface-water sources in the parish is presented. Previously published reports and data stored in the U.S. Geological Survey’s National Water Information System (http://waterdata.usgs.gov/nwis) are the primary sources of the information presented here.

  18. Project StORe: Social Science report

    OpenAIRE

    Burton, Guy

    2006-01-01

    There was widespread support across the social science research community regarding the aims of the StORe Project Nearly half of social science respondents claimed that both source-to-output and out-put-to source repositories would offer a ‘significant advantage to my work’; a third in both cases claimed it would be ‘useful but not of major significance’ Postgraduate students were generally more enthusiastic about source-to-output and output-to-source repositories than acade...

  19. Ambulatory ST segment monitoring after myocardial infarction

    DEFF Research Database (Denmark)

    Mickley, H

    1994-01-01

    as important reasons for the inconsistent findings. The precise role of ambulatory ST segment monitoring in clinical practice has yet to be established. Direct comparisons with exercise stress testing may not be appropriate for two reasons. Firstly, the main advantage of ambulatory monitoring may...... ischaemia provides prognostic information in different subsets of patients with previous myocardial infarction, but there is considerable disagreement about how this is expressed in terms of cardiac events. Small patient numbers, patient selection, and different timing of ambulatory monitoring are proposed...

  20. Great III - Cultural Resource Inventory. Volume 2

    Science.gov (United States)

    1982-05-01

    Historical Sketch of St. Louis University. Patrick Fox, • St. Louis. Historical look at the St. Louis mound complex. Holmes, Nathaniel 1868 Loess...Saint Louis to Me. St. Louis, Missouri: Hawthorn Pub- lishing Company, 1978. 305 p., illus. £ates, Giwendolyn Lewis 1976 Historic Sites Inventory for...Watercolors by Marilynne Bradley. St. Louis: Hawthorn Publishing Company, c. 1977. 259 p., illus. (part color). Includes: Old Courthouse, Old

  1. COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation

    Directory of Open Access Journals (Sweden)

    Rafael Pérez-Pérez

    2016-08-01

    Full Text Available Mitochondrial respiratory chain (MRC complexes I, III, and IV associate into a variety of supramolecular structures known as supercomplexes and respirasomes. While COX7A2L was originally described as a supercomplex-specific factor responsible for the dynamic association of complex IV into these structures to adapt MRC function to metabolic variations, this role has been disputed. Here, we further examine the functional significance of COX7A2L in the structural organization of the mammalian respiratory chain. As in the mouse, human COX7A2L binds primarily to free mitochondrial complex III and, to a minor extent, to complex IV to specifically promote the stabilization of the III2+IV supercomplex without affecting respirasome formation. Furthermore, COX7A2L does not affect the biogenesis, stabilization, and function of the individual oxidative phosphorylation complexes. These data show that independent regulatory mechanisms for the biogenesis and turnover of different MRC supercomplex structures co-exist.

  2. MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals.

    Science.gov (United States)

    Yuan, Jia; Zhang, Ying; Sheng, Yue; Fu, Xiazhou; Cheng, Hanhua; Zhou, Rongjia

    2015-01-01

    Oogenesis is essential for female gamete production in mammals. The total number of ovarian follicles is determined early in life and production of ovarian oocytes is thought to stop during the lifetime. However, the molecular mechanisms underling oogenesis, particularly autophagy regulation in the ovary, remain largely unknown. Here, we reveal an important MYBL2-VDAC2-BECN1-BCL2L1 pathway linking autophagy suppression in the developing ovary. The transcription factors GATA1 and MYBL2 can bind to and activate the Vdac2 promoter. MYBL2 regulates the spatiotemporal expression of VDAC2 in the developing ovary. Strikingly, in the VDAC2 transgenic pigs (Sus scrofa/Ss), VDAC2 exerts its function by inhibiting autophagy in the ovary. In contrast, Vdac2 knockout promotes autophagy. Moreover, VDAC2-mediated autophagy suppression is dependent on its interactions with both BECN1 and BCL2L1 to stabilize the BECN1 and BCL2L1 complex, suggesting VDAC2 as an autophagy suppressor in the pathway. Our findings provide a functional connection among the VDAC2, MYBL2, the BECN1-BCL2L1 pathway and autophagy suppression in the developing ovary, which is implicated in improving female fecundity.

  3. Differentiating ST elevation myocardial infarction and nonischemic causes of ST elevation by analyzing the presenting electrocardiogram

    DEFF Research Database (Denmark)

    Jayroe, Jason B; Spodick, David H; Nikus, Kjell;

    2008-01-01

    Guidelines recommend that patients with suggestive symptoms of myocardial ischemia and ST-segment elevation (STE) in > or =2 adjacent electrocardiographic leads should receive immediate reperfusion therapy. Novel strategies aimed to reduce door-to-balloon time, such as prehospital wireless electr...

  4. Outbreak of KPC-3-producing ST15 and ST348 Klebsiella pneumoniae in a Portuguese hospital.

    Science.gov (United States)

    Vubil, D; Figueiredo, R; Reis, T; Canha, C; Boaventura, L; DA Silva, G J

    2017-02-01

    To date, only a few sporadic cases of infections due to Klebsiella pneumoniae carbapenemase (KPC) producers have been reported in Portugal. Here, we report for the first time an outbreak of K. pneumoniae KPC-3 producers in a tertiary-care hospital during 2013. Twenty-seven ertapenem-resistant K. pneumoniae were identified in patients at a tertiary-care hospital during 2013 isolated predominantly from urine (48·1%) and blood (25·9%) cultures. All isolates were highly resistant to β-lactam antibiotics and most showed intermediate resistance to imipenem. The more frequent β-lactamases were TEM- (77·7%), CTX-M- (70·3%) and KPC-type (66·6%). KPC-3 was identified by sequencing. The bla KPC-3 gene was associated with an IncF plasmid, and efficiently transferred to E. coli J53. Pulsed-field gel electrophoresis typing revealed three clusters of isolates which were further characterized by multi-locus sequence typing as ST11, ST15 and ST348. Ertapenem-resistant ST15 was already in circulation in the hospital, related to expression of OmpK36 modified porin, but the other two sequence types had not been previously found in the hospital. We conclude that the IncF plasmid mediated transfer of KPC-3 in the outbreak and that implementation of carbapenemase gene screening in isolates from patients on admission to hospital is advisable in order to control dissemination of these antimicrobial resistance elements.

  5. Principal Component Surface (2011) for St. Thomas East End Reserve, St. Thomas

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a 0.3x0.3 meter principal component analysis (PCA) surface for areas the St. Thomas East End Reserve (STEER) in the U.S. Virgin Islands (USVI)....

  6. Pluralism and Longstanding Value of S&T Development

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    With the strategic opportunities brought about by the current S&T revolution, new and higher requirements have been set for the S&T system so as to accelerate the transformation of the economic growth mode with S&T development.In 2009, the CAS Academic Divisions (CASAD) Committee of Consultation and Evaluation formed a research panel to examine how to enable China's S&T system and policies to fit the needs of strategic development in the new era.The panel conducted a survey of S&T workers and administrators, with questionnaire covering issues raised by CAS Members and other experts.Then, on the basis of findings from symposia and the survey, the research team analyzed deep-seated mechanism and policy problems concerning China's current and longstanding S&T development.

  7. The cognitive status of stød

    DEFF Research Database (Denmark)

    Clausen, Sara Juul; Kristensen, Line Burholt

    2015-01-01

    The Danish prosodic phenomenon stød is associated with a specific range of suffixes including the singular definite suffixes -en and -et. Diachronically, as well as distributionally, stød is related to Swedish/Norwegian accent 1, but unlike accent 1, stød is seen as phonetically and phonologically...... marked. Keeping in mind the cross-distribution between phonetic/phonological markedness and distributional patterns, we investigate here whether stød is also related to accent 1 when it comes to cognitive markedness. We present the results of a psycholinguistic study in which participants attended...... to words that were either appropriate combinations of prosody (stød vs. non-stød) and suffix (singular definite -en/-et vs. plural indefinite -e) or mismatches between prosody and suffix. Participants gave slower and more inaccurate responses to mismatches. This effect of mismatch was most pronounced...

  8. ELECTRICITY/COOLING/VENTILATION CUT NOTICES OF THE ST DIVISION

    CERN Multimedia

    Groupes ST-EL, ST-TFM, ST-CV

    1999-01-01

    The electricity, cooling and ventilation system cut notices of the ST division are now available on the Web via a pilot project EDMS from the Home Page of the ST Division:http://www.cern.ch/CERN/Divisions/ST/The proposed structure can be subject to modifications; a search system for the notices is under study by the EDMS team and will be installed before Christmas.The paper distribution of the notices is now replaced by electronic message system. All persons subscribed to the existing distribution lists will receive e-mail with notices attached.For additional information or remarks, please send e-mail to Evelyne.Cochet@cern.ch.ST-EL, ST-TFM, ST-CV Groups

  9. Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Gu Harvest F

    2010-07-01

    Full Text Available Abstract Background MCF2L2, ADIPOQ and SOX2 genes are located in chromosome 3q26-27, which is linked to diabetic nephropathy (DN. ADIPOQ and SOX2 genetic polymorphisms are found to be associated with DN. In the present study, we first investigated the association between MCF2L2 and DN, and then evaluated effects of these three genes on the development of DN. Methods A total of 1177 type 1 diabetes patients with and without DN from the GoKinD study were genotyped with TaqMan allelic discrimination. All subjects were of European descent. Results Leu359Ile T/G variant in the MCF2L2 gene was found to be associated with DN in female subjects (P = 0.017, OR = 0.701, 95%CI 0.524-0.938 but not in males. The GG genotype carriers among female patients with DN had tendency decreased creatinine and cystatin levels compared to the carriers with either TT or TG genotypes. This polymorphism MCF2L2-rs7639705 together with SNPs of ADIPOQ-rs266729 and SOX2-rs11915160 had combined effects on decreased risk of DN in females (P = 0.001. Conclusion The present study provides evidence that MCF2L2, ADIPOQ and SOX2 genetic polymorphisms have effects on the resistance of DN in female T1D patients, and suggests that the linkage with DN in chromosome 3q may be explained by the cumulated genetic effects.

  10. Volumes of chain links

    CERN Document Server

    Kaiser, James; Rollins, Clint

    2011-01-01

    Agol has conjectured that minimally twisted n-chain links are the smallest volume hyperbolic manifolds with n cusps, for n at most 10. In his thesis, Venzke mentions that these cannot be smallest volume for n at least 11, but does not provide a proof. In this paper, we give a proof of Venzke's statement. The proof for n at least 60 is completely rigorous. The proof for n between 11 and 59 uses a computer calculation, and can be made rigorous for manifolds of small enough complexity, using methods of Moser and Milley. Finally, we prove that the n-chain link with 2m or 2m+1 half-twists cannot be the minimal volume hyperbolic manifold with n cusps, provided n is at least 60 or |m| is at least 8, and we give computational data indicating this remains true for smaller n and |m|.

  11. HARNESSING BIG DATA VOLUMES

    Directory of Open Access Journals (Sweden)

    Bogdan DINU

    2014-04-01

    Full Text Available Big Data can revolutionize humanity. Hidden within the huge amounts and variety of the data we are creating we may find information, facts, social insights and benchmarks that were once virtually impossible to find or were simply inexistent. Large volumes of data allow organizations to tap in real time the full potential of all the internal or external information they possess. Big data calls for quick decisions and innovative ways to assist customers and the society as a whole. Big data platforms and product portfolio will help customers harness to the full the value of big data volumes. This paper deals with technical and technological issues related to handling big data volumes in the Big Data environment.

  12. Knowledge society in 21st century

    Directory of Open Access Journals (Sweden)

    Martina Urbanová

    2012-01-01

    Full Text Available This paper is focused on the increasing need of education in 21st century and on some problems which emerged in this context – the economists prefer to emphasize the development and growth, profit and effectiveness, and they can overlook general, ethical, and essential problems and needs of the contemporary world. These problems are not resolved by simple algometrical approaches, but they require multi-disciplined paradigms, which can provide social sciences.Especially in the 21st century we need wide-ranging critical thinking as a basis of responsible ethical behaviour. However in the current educational environment in the tertiary educational system we can observe over-emphasizing of utilitarian requirements. We produce professionals who are expected to be able to find quick, effective but also far-seeing solutions of any given problem, which is in obvious contradiction. This article discussed three conceptions of a human with the emphasis on the concept of “homo socio-oeconomicus”. This concept enables to see the world in wide context and develops necessary critical thinking, which is also economically more advantageous from the long-term point of view. That is why education in sociological, psychological, philosophical, political and other social sciences should not be considered by economists as something useless without any economic value, but as something that can help them to understand themselves, their environment and the consequences of their decisions. This is the core of this contribution.

  13. Retendering of ST-CV maintenance contract

    CERN Document Server

    Battistin, M

    2003-01-01

    During the next three years, the ST/CV group will be deeply involved in the installation works for the LHC project. During this period the need for maintenance activity will decrease. The minimum level will be reached during the “long shutdown” of the PS and SPS machines in 2005. The budget for the maintenance will decrease accordingly, thus the CV group had to review its maintenance strategy. The new contract, which started on January 1st 2003, has been defined to cope with these workload variations during the next years and to guarantee the minimum maintenance activity on the existing equipment. A lump-sum contract based on a win-win strategy has been discarded. The contractor no longer has to guarantee the performance of the CERN cooling and ventilation systems. A new price list strategy based on performance indicators and penalties has been chosen. The contractor now has to guarantee the performance of every maintenance operation demanded by CERN. This modification obliged the Operation section of the...

  14. Nursing heroism in the 21st Century'

    Directory of Open Access Journals (Sweden)

    Darbyshire Philip

    2011-02-01

    Full Text Available Abstract Background The Vivian Bullwinkel Oration honours the life and work of an extraordinary nurse. Given her story and that of her World War II colleagues, the topic of nursing heroism in the 21st century could not be more germane. Discussion Is heroism a legitimate part of nursing, or are nurses simply 'just doing their job' even when facing extreme personal danger? In this paper I explore the place and relevance of heroism in contemporary nursing. I propose that nursing heroism deserves a broader appreciation and that within the term lie many hidden, 'unsung' or 'unrecorded' heroisms. I also challenge the critiques of heroism that would condemn it as part of a 'militarisation' of nursing. Finally, I argue that nursing needs to be more open in celebrating our heroes and the transformative power of nursing achievements. Summary The language of heroism may sound quaint by 21st Century standards but nursing heroism is alive and well in the best of our contemporary nursing ethos and practice.

  15. Federal laboratories for the 21st century

    Energy Technology Data Exchange (ETDEWEB)

    Gover, J. [Sandia National Labs., Albuquerque, NM (United States); Huray, P.G. [Univ. of South Carolina, Columbia, SC (United States)

    1998-04-01

    Federal laboratories have successfully filled many roles for the public; however, as the 21st Century nears it is time to rethink and reevaluate how Federal laboratories can better support the public and identify new roles for this class of publicly-owned institutions. The productivity of the Federal laboratory system can be increased by making use of public outcome metrics, by benchmarking laboratories, by deploying innovative new governance models, by partnerships of Federal laboratories with universities and companies, and by accelerating the transition of federal laboratories and the agencies that own them into learning organizations. The authors must learn how government-owned laboratories in other countries serve their public. Taiwan`s government laboratory, Industrial Technology Research Institute, has been particularly successful in promoting economic growth. It is time to stop operating Federal laboratories as monopoly institutions; therefore, competition between Federal laboratories must be promoted. Additionally, Federal laboratories capable of addressing emerging 21st century public problems must be identified and given the challenge of serving the public in innovative new ways. Increased investment in case studies of particular programs at Federal laboratories and research on the public utility of a system of Federal laboratories could lead to increased productivity of laboratories. Elimination of risk-averse Federal laboratory and agency bureaucracies would also have dramatic impact on the productivity of the Federal laboratory system. Appropriately used, the US Federal laboratory system offers the US an innovative advantage over other nations.

  16. Boosting 21st Century Skills through Moroccan ELT Textbooks

    OpenAIRE

    Hassan Ait Bouzid

    2016-01-01

    Research shows that the changing realities of the 21st century necessitate a fundamental shift in language education towards promoting 21st Century Skills. This paper investigates the extent to which three Moroccan ELT textbooks currently used in teaching second year Baccalaureate students in public high school provide activities that help learners build skills that match the needs of the 21st century. It also explores the types of activities that are used to promote these skills and eventual...

  17. Chicago-St. Louis high speed rail plan

    Energy Technology Data Exchange (ETDEWEB)

    Stead, M.E.

    1994-12-31

    The Illinois Department of Transportation (IDOT), in cooperation with Amtrak, undertook the Chicago-St. Louis High Speed Rail Financial and Implementation Plan study in order to develop a realistic and achievable blueprint for implementation of high speed rail in the Chicago-St. Louis corridor. This report presents a summary of the Price Waterhouse Project Team`s analysis and the Financial and Implementation Plan for implementing high speed rail service in the Chicago-St. Louis corridor.

  18. Frauen mit Eßstörungen im Ausdauersport

    OpenAIRE

    Bös, Annette

    2003-01-01

    Die vorliegende Arbeit untersucht das Phänomen Eßstörungen bei Ausdauersportlerinnen. Auf dem Hintergrund des identitätstheoretischen Ansatzes von Stahr et al. (1995) geht es um die Frage nach den Hauptverursachungsmomenten der Eßstörungen von sieben jungen Sportlerinnen. Im Rahmen einer qualitativen Sozialforschungsarbeit wurden sieben Athletinnen in einem problemzentrierten Interview zur Phase ihrer Eßstörungserkrankung befragt. Die Arbeit setzt sich zum Ziel, einen Beitrag zur systematisch...

  19. St. George at Prague Castle and Perseus: an Impossible Encounter?

    OpenAIRE

    Bažant, J. (Jan)

    2015-01-01

    St. George and Perseus crossed their paths for the first time in the 11th century when the myth of Greek hero inspired the legend of a Christian saint. In the 14th century, the pictorial types of St. George, Perseus and Bellerphon fighting the dragon started converging. The famous bronze statue of St. George at the Prague Castle, which was creted in 1373, represents an advanced stage opf the process.

  20. New reduced volume preparation regimen in colon capsule endoscopy

    Institute of Scientific and Technical Information of China (English)

    Yasuo Kakugawa; Kazuhide Higuchi; Shinji Tanaka; Hideki Ishikawa; Hisao Tajiri; Yutaka Saito; Shoichi Saito; Kenji Watanabe; Naoki Ohmiya; Mitsuyuki Murano; Shiro Oka; Tetsuo Arakawa; Hidemi Goto

    2012-01-01

    AIM:To evaluate the effectiveness of our proposed bowel preparation method for colon capsule endoscopy.METHODS:A pilot,multicenter,randomized controlled trial compared our proposed "reduced volume method" (group A) with the "conventional volume method" (group B) preparation regimens.Group A did not drink polyethylene glycol electrolyte lavage solution (PEGELS) the day before the capsule procedure,while group B drank 2 L.During the procedure day,groups A and B drank 2 L and 1 L of PEG-ELS,respectively,and swallowed the colon capsule (PillCam COLON(R) capsule).Two hours later the first booster of 100 g magnesium citrate mixed with 900 mL water was administered to both groups,and the second booster was administered six hours post capsule ingestion as long as the capsule had not been excreted by that time.Capsule videos were reviewed for grading of cleansing level.RESULTS:Sixty-four subjects were enrolled,with results from 60 analyzed.Groups A and B included 31 and 29 subjects,respectively.Twenty-nine (94%) subjects in group A and 25 (86%) subjects in group B had adequate bowel preparation (ns).Twenty-two (71%) of the 31 subjects in group A excreted the capsule within its battery life compared to 16 (55%) of the 29 subjects in group B (ns).Of the remaining 22 subjects whose capsules were not excreted within the battery life,all of the capsules reached the left side colon before they stopped functioning.A single adverse event was reported in one subject who had mild symptoms of nausea and vomiting one hour after starting to drink PEG-ELS,due to ingesting the PEG-ELS faster than recommended.CONCLUSION:Our proposed reduced volume bowel preparation method for colon capsule without PEG-ELS during the days before the procedure was as effective as the conventional volume method.

  1. Topological Active Volumes

    Directory of Open Access Journals (Sweden)

    Barreira N

    2005-01-01

    Full Text Available The topological active volumes (TAVs model is a general model for 3D image segmentation. It is based on deformable models and integrates features of region-based and boundary-based segmentation techniques. Besides segmentation, it can also be used for surface reconstruction and topological analysis of the inside of detected objects. The TAV structure is flexible and allows topological changes in order to improve the adjustment to object's local characteristics, find several objects in the scene, and identify and delimit holes in detected structures. This paper describes the main features of the TAV model and shows its ability to segment volumes in an automated manner.

  2. Aperiodic Volume Optics

    Science.gov (United States)

    Gerke, Tim D.

    Presented in this thesis is an investigation into aperiodic volume optical devices. The three main topics of research and discussion are the aperiodic volume optical devices that we call computer-generated volume holograms (CGVH), defects within periodic 3D photonic crystals, and non-periodic, but ordered 3D quasicrystals. The first of these devices, CGVHs, are designed and investigated numerically and experimentally. We study the performance of multi-layered amplitude computer-generated volume holograms in terms of efficiency and angular/frequency selectivity. Simulation results show that such aperiodic devices can increase diffraction efficiency relative to periodic amplitude volume holograms while maintaining angular and wavelength selectivity. CGVHs are also designed as voxelated volumes using a new projection optimization algorithm. They are investigated using a volumetric diffraction simulation and a standard 3D beam propagation technique as well as experimentally. Both simulation and experiment verify that the structures function according to their design. These represent the first diffractive structures that have the capacity for generating arbitrary transmission and reflection wave fronts and that provide the ability for multiplexing arbitrary functionality given different illumination conditions. Also investigated and discussed in this thesis are 3D photonic crystals and quasicrystals. We demonstrate that these devices can be fabricated using a femtosecond laser direct writing system that is particularly appropriate for fabrication of such arbitrary 3D structures. We also show that these devices can provide 3D partial bandgaps which could become complete bandgaps if fabricated using high index materials or by coating lower index materials with high index metals. Our fabrication method is particularly suited to the fabrication of engineered defects within the periodic or quasi-periodic systems. We demonstrate the potential for fabricating defects within

  3. The volume of a soliton

    Energy Technology Data Exchange (ETDEWEB)

    Adam, C., E-mail: adam@fpaxp1.usc.es [Departamento de Física de Partículas, Universidad de Santiago de Compostela and Instituto Galego de Física de Altas Enerxias (IGFAE), E-15782 Santiago de Compostela (Spain); Haberichter, M. [School of Mathematics, Statistics and Actuarial Science, University of Kent, Canterbury, CT2 7NF (United Kingdom); Wereszczynski, A. [Institute of Physics, Jagiellonian University, Lojasiewicza 11, Kraków (Poland)

    2016-03-10

    There exists, in general, no unique definition of the size (volume, area, etc., depending on dimension) of a soliton. Here we demonstrate that the geometric volume (area etc.) of a soliton is singled out in the sense that it exactly coincides with the thermodynamical or continuum-mechanical volume. In addition, this volume may be defined uniquely for rather arbitrary solitons in arbitrary dimensions.

  4. The cognitive status of stød

    DEFF Research Database (Denmark)

    Clausen, Sara Juul; Kristensen, Line Burholt

    2015-01-01

    The Danish prosodic phenomenon stød is associated with a specific range of suffixes including the singular definite suffixes -en and -et. Diachronically, as well as distributionally, stød is related to Swedish/Norwegian accent 1, but unlike accent 1, stød is seen as phonetically and phonologically...... marked. Keeping in mind the cross-distribution between phonetic/phonological markedness and distributional patterns, we investigate here whether stød is also related to accent 1 when it comes to cognitive markedness. We present the results of a psycholinguistic study in which participants attended...

  5. Injury Prevention and Performance Enhancement in 101st Airbourne Soldiers

    Science.gov (United States)

    2012-02-01

    Crawford K, Darnell ME, Abt JP, Sell TC, Lovalekar MT, House AJ, Smalley BW, Lephart SM. Dietary Habits of Soldiers of 101st Airborne Division Air...W81XWH-06-2-0070 and #W81XWH-09-2-0095 Dietary Habits of Soldiers of 101stAirborne Division Air Assault Kim Crawford, Matthew E. Darnell, John P. Abt...physical and tactical training. PURPOSE: To evaluate dietary habits of 101stAirborne Division (Air Assault) (101st ABN DIV (AA)) Soldiers. METHODS: A

  6. 21st International Symposium on Spin Physics

    CERN Document Server

    Ma, Bo-Qiang; SPIN 2014; SPIN2014

    2016-01-01

    This special volume collected important papers written by leading experts, highlighting the latest research findings in various topics of spin phenomena in particle and nuclear physics. The contents are originated from the plenary talks at the latest symposium of the Spin Physics series (SPIN2014) which was held in Beijing, China, October 20-24, 2014.The volume also comprises a special collection of contributions in memory of the late Professor Michel Borghini, an outstanding physicist well remembered for his great contributions to the progress of high energy spin physics.

  7. 地西他滨对胃癌SGC7901细胞系BCL2L10基因表达及其生物学特性的影响%Effects of decitabine on the expression of BCL2L10 and biological behaviors in gastric cancer cell line SGC7901

    Institute of Scientific and Technical Information of China (English)

    孔秀敏; 王晓兰

    2013-01-01

    目的:观察抗肿瘤新药地西他滨对胃癌细胞系SGC7901中抗凋亡基因BCL2L10启动子甲基化及基因表达的影响,探讨其对胃癌细胞生物学行为的影响.方法:用浓度为5、10 μmol/L的地西他滨处理胃癌细胞SGC7901,应用甲基化特异性PCR检测BCL2L10基因启动子甲基化状况,应用免疫印迹检测BCL2L10蛋白表达,MTS法检测细胞增殖情况,annexin V-FITC/PI双染检测细胞凋亡,siRNA干扰BCL2L10表达以探讨地西他滨可能的作用机制.结果:SGC7901细胞中BCL2L10基因以启动子甲基化方式失活,地西他滨呈剂量依赖方式逆转其甲基化程度,恢复基因表达,同时可见细胞增殖受到抑制,凋亡比例增加,而干扰BCL2L10可对抗地西他滨的抗肿瘤效应.结论:地西他滨可通过逆转胃癌SGC7901细胞系BCL2L10启动子甲基化而恢复其表达,表现出抗肿瘤活性,具有潜在的临床应用价值.%Objective:To investigate the impact of decitabine on the methylation of BCL2L10 promoter and gene expression in gastric cancer cell line SGC7901,and to explore its effects on the oncological behavior of gastric cancer.Methods:SGC7901 cells were treated with decitabine at the concentration of 5μmol/L and 10μmol/L.The methylation status of BCL2L10 promoter was detected by methylation-specific PCR,and the protein expression was detected by immunoblotting.The proliferation of SGC7901 cells was measured with MTS reagent,and the apoptosis was examined by annexin V-FITC/PI double staining.BLC2L10-specific siRNA was constructed and transfected into SGC7901 cells to further explore the potential mechanisms of decitabine.Results:The promoter of BCL2L10 in SGC7901 cells was hypermethylated and its expression was completely lost.Decitabine treatment reversed the methylation status of BCL2L10 and restored its protein expression in a dose-dependent manner.Meanwhile,the proliferation of SGC7901 was inhibited by decitabine treatment,whereas the apoptotic rate was

  8. Design for volume reduction

    NARCIS (Netherlands)

    Wever, R.; Boks, C.; Stevels, A.

    2007-01-01

    Traditionally packaging design-for-sustainability (DfS) strongly focuses on resource conservation and material recycling. The type and amount of materials used has been the driver in design. For consumer electronics (CE) products this weight-based approach is too limited; a volume-based approach is

  9. Introduction to the Volume.

    Science.gov (United States)

    Emihovich, Catherine; Schroder, Barbara; Panofsky, Carolyn P.

    1999-01-01

    Introduces a volume that examines the issue of critical thinking and whether or not it is culturally specific, discussing recent research on the subject. The papers focus on critical thinking and culture, historical consciousness and critical thinking, critical thinking as cultural-historical practice, culture and the development of critical…

  10. Adenomatous hyperplasia of the thyroid gland in beluga whales (Delphinapterus leucas) from the St. Lawrence Estuary and Hudson Bay, Quebec, Canada.

    Science.gov (United States)

    Mikaelian, I; Labelle, P; Kopal, M; De Guise, S; Martineau, D

    2003-11-01

    We evaluated thyroid gland lesions in beluga whales (Delphinapterus leucas) from the St. Lawrence Estuary (n = 16) and Hudson Bay (n = 14). Follicular cysts and nodules of adenomatous hyperplasia of the thyroid gland were found in eight and nine adults from the St. Lawrence Estuary (n = 10), respectively, and in four and six adults from Hudson Bay (n = 14), respectively. The total volume of the lesions of thyroid adenomatous hyperplasia was positively correlated with age in both populations. Comparison between populations could not be performed because of differences in age structures of sample groups. Beluga whales from both populations have unique thyroid lesions among marine mammals.

  11. NJP VOLUME 42 NO 2

    African Journals Online (AJOL)

    PROF. EZECHUKWU

    2014-11-29

    Nov 29, 2014 ... compared with other childhood malignancies for Asian and Caucasian groups. ..... cluding rhabdomyosarcoma as infrequent, accounting for 6.5% of all cancers in .... 5th edition, Mosby Year Books St. Louis Missouri 1998 ...

  12. The early stages of growth of Mn deposited at room temperature on Ag (001) studied by Mn K-edge SEXAFS and Mn L/sub 2/, L/sub 3/-edges XAS

    CERN Document Server

    Schieffer, P; Krembel, C; Hanf, M C; Gewinner, G; Chandesris, D; Magnan, H; Hricovini, K

    1999-01-01

    The atomic structure of the Ag/sub 0.5/Mn/sub 0.5/ ordered surface alloy formed in the two topmost layers of the Ag substrate when 1 monolayer (ML) Mn is deposited at room temperature on Ag(001) is determined by using Mn K-edge surface extended X-ray absorption fine structure (SEXAFS). The results, which are in agreement with the c (2*2) low energy electron diffraction (LEED) pattern and X-ray photoelectron diffraction (XPD), establishes that Mn adopts here an unusually large atomic volume which is consistent with a large atomic-like moment. The Mn L/sub 2/L/sub 3/ edges soft X-ray absorption spectroscopy (XAS) study of 1ML Mn in-situ deposited confirms that Mn adopts a stable high spin state. For thicker deposits, the growth of a body-centered tetragonal lattice of pure Mn on this diffuse interface is confirmed. (14 refs).

  13. Tribological Technology. Volume II.

    Science.gov (United States)

    1982-09-01

    TABLE 7 PRESSURE-VISCOSITY COEFFICIENTS (REF. 11) I - . ..- 445 103 -- 02 -s 10 00 A04wCm eve * oPe’-re’ -.* : ;-T’ enl mne-SI C. oC-ftht’E 050 100...821745~r A𔃿 32 l C 225 Mt25 5 12 o60 310 it 34C 6 85 io 11 * 3f5 . 295 t~ri~ Lortoing.~ eve lrsi~in4635 W-ongor St. K-o,- CrY. Wi~- 84 112 -7.BLE 11...forming on the surfaces and this phenomenon has been used by March and Rabinowicz (1976) for incipient fatigu 6 investigations using a rolling four-ball

  14. Cooperative learning in 21st century

    Directory of Open Access Journals (Sweden)

    David W. Johnson

    2014-10-01

    Full Text Available The 21st century brings four important challenges in which cooperation plays a central role: (1 a rapidly increasing global interdependence that will result in increasing local diversity as well as more frequent and intense conflicts, (2 the increasing number of democracies throughout the world, (3 the need for creative entrepreneurs, and (4 the growing importance of interpersonal relationships that affect the development of personal identity. The tools for meeting these challenges include cooperative learning. In this article the nature of cooperative learning will be reviewed, the underlying theory of social interdependence will be discussed, and the results of the research on cooperative learning will be briefly reviewed. The way in which cooperative learning contributes to meeting the four challenges will then be discussed.

  15. Maintenance Management in the ST Division

    CERN Document Server

    Rühl, I

    2001-01-01

    The Maintenance Manager Working Group was established in order to revise existing maintenance contracts and to provide comprehensive and applicable tools for the execution of maintenance activities in the ST Division. This was necessary mainly due to the fact that the maintenance plans in the Division have often evolved rather than being consciously set up and in respect to the change towards result orientated contracts. Also, because the decrease of CERN staff and the trend towards outsourcing, a tighter and well-organised maintenance management has to be established. In order to achieve the most realistic and applicable results the technical and commercial aspects must be considered by following the industrial approach. This document will outline the objectives of the working group and will show the progress that has been made by the implementation of already achieved results. Furthermore this paper will show a possible structure of future maintenance management.

  16. Digital Humanities in the 21st Century

    DEFF Research Database (Denmark)

    Brügger, Niels

    2016-01-01

    In this article it is argued that one of the major transformative factors of the humanities at the beginning of the 21st century is the shift from analogue to digital source material, and that this shift will affect the humanities in a variety of ways. But various kinds of digital material...... are not digital in the same way, which a distinction between digitized, born-digital, and reborn-digital may help us acknowledge, thereby helping us to understand how each of these types of digital material affects different phases of scholarly work in its own way. This is illustrated by a detailed comparison...... of the nature of digitized collections and web archives....

  17. 1st Applied Electromagnetic International Conference

    CERN Document Server

    Othman, Mohd; Aziz, Mohamad; Malek, Mohd

    2015-01-01

    In this book, experts from academia and industry present the latest advances in scientific theory relating to applied electromagnetics and examine current and emerging applications particularly within the fields of electronics, communications, and computer technology. The book is based on presentations delivered at APPEIC 2014, the 1st Applied Electromagnetic International Conference, held in Bandung, Indonesia in December 2014. The conference provided an ideal platform for researchers and specialists to deliver both theoretically and practically oriented contributions on a wide range of topics relevant to the theme of nurturing applied electromagnetics for human technology. Many novel aspects were addressed, and the contributions selected for this book highlight the relevance of advances in applied electromagnetics to a variety of industrial engineering problems and identify exciting future directions for research.

  18. Antiparasitic DNA vaccines in 21st century.

    Science.gov (United States)

    Wedrychowicz, Halina

    2015-06-01

    Demands for effective vaccines to control parasitic diseases of humans and livestock have been recently exacerbated by the development of resistance of most pathogenic parasites to anti-parasitic drugs. Novel genomic and proteomic technologies have provided opportunities for the discovery and improvement of DNA vaccines which are relatively easy as well as cheap to fabricate and stable at room temperatures. However, their main limitation is rather poor immunogenicity, which makes it necessary to couple the antigens with adjuvant molecules. This paper review recent advances in the development of DNA vaccines to some pathogenic protozoa and helminths. Numerous studies were conducted over the past 14 years of 21st century, employing various administration techniques, adjuvants and new immunogenic antigens to increase efficacy of DNA vaccines. Unfortunately, the results have not been rewarding. Further research is necessary using more extensive combinations of antigens; alternate delivery systems and more efficient adjuvants based on knowledge of the immunomodulatory capacities of parasitic protozoa and helminths.

  19. St.boy也爱Hip-Hop

    Institute of Scientific and Technical Information of China (English)

    牛艳红

    2004-01-01

    很少有爱“st.boy”的男孩儿不爱“Hip Hop”。发源于20世纪80年代美国黑人青少年的“街头舞蹈”,被喜欢张扬自我个性,展示青春的活力和激情的现代日韩青年们称为“Hip Hop”,他们通过这种不拘于地点.场所和道具。吸取了嘻哈变体文化的独特舞蹈,来表达勇于进取的生活态度,强调一种属于现代青年的“做自己,享受生命.勇于挑战”的理念。

  20. Effective Leadership in the 21st Century.

    Science.gov (United States)

    Jones, Jacqueline

    2015-01-01

    Leaders know how to achieve goals and inspire people along the way. While the terms and definitions may change with the times, it is important to understand the skills and abilities needed to lead in the 21st century. Most effective leaders have one element in common, and that is they are able to keep their teams engaged. If team members are not engaged, they may very well leave the organization. With four generations in the workplace, leaders must adapt and modify their leadership style in order to maintain employee engagement. The ability to lead effectively is based on a number of skills, including communication, motivation, vision, modeling, demonstrating empathy, confidence, persistence, and integrity.

  1. Caruso St John y Robert Smithson: Interferencias

    Directory of Open Access Journals (Sweden)

    Emilia Hernández Pezzi

    2016-05-01

    Full Text Available Resumen Los discursos cruzados son el soporte común del presente número de Cuadernos. El cruce que planteamos tiene como protagonistas al artista Robert Smithson y a los arquitectos Adam Caruso y Peter St John. Estos últimos hacen mención del trabajo del artista norteamericano para explicar su proyecto de remodelación de Stortorget, la plaza de la catedral en el centro de Kalmar, Suecia. A partir de aquí, comenzamos una exploración del trabajo y las preocupaciones de ambos que nos permite dibujar convergencias y sintonías procesuales por encima de las diferencias temáticas, ideológicas y estilísticas. Al disponer en paralelo la obra de Smithson y Caruso St John descubrimos vibraciones y resonancias que muestran una interacción productiva de sus preocupaciones. La materia se convierte en sus propuestas en un objeto activo y sensible, un depósito energético con el que operar. El traslado de piedras en Stortorget convoca la memoria de la ciudad del mismo modo que el basalto y la sal del Spiral Jetty, erosionados por el tiempo, nos hablan de procesos abiertos. El tiempo y la memoria pasan a ser soportes estratégicos con los que construyen sus miradas. Los objetos se disuelven en las relaciones que establecen con su entorno produciendo equilibrios frágiles e instantáneos. De esta manera el artículo pretende generar un vórtice de reflexión, una espiral en cuyo recorrido se manifiesten las tensiones parciales del cruce propuesto, sus fijezas momentáneas.

  2. The 2015 St Patrick's Day Storm: Origins

    Science.gov (United States)

    Carlyle, Jack; van Driel-Gesztelyi, Lidia; Zuccarello, Francesco; James, Alexander; Williams, David

    2017-08-01

    The magnetic storm experienced at Earth on St. Patrick's Day 2015 had been the strongest of cycle 24 (at that time) with a measured DST of -223 nT, though it was not expected to cause much of a disturbance. In this work we study the solar source region of several peculiar eruptions, leading to the formation and destruction of various structures, in the week leading up to the storm, and determine the true sequence of events. The evolution of the magnetic flux at the solar surface is examined in order to place suspected flux-ropes into context, and the evolution of the magnetic connectivities is described alongside a PFSS model of the surrounding region. The balance between positive and negative flux directly before two key eruptions is investigated in detail, in order to ascertain whether particular trigger mechanisms are feasible explanations. As well as these magnetic investigations, the column density of plasma involved is calculated from extreme ultraviolet images, and this is used to estimate the total mass of one filament, as well as select other features relevant to the eruptions. This information is then used to comment on the energy budgets and requirements of several processes in order to best understand the underlying drivers of this event.Previous studies on the St. Patrick's Day Storm are also incorporated into this work, and an attempt is made to reconcile the disparate conclusions drawn by the scientific community as to why this storm was not only so effective, but also a major forecasting failure.

  3. Attenuation of vaccinia Tian Tan strain by removal of viral TC7L-TK2L and TA35R genes.

    Directory of Open Access Journals (Sweden)

    Shifu Kan

    Full Text Available Vaccinia Tian Tan (VTT was attenuated by deletion of the TC7L-TK2L and TA35R genes to generate MVTT3. The mutant was generated by replacing the open reading frames by a gene encoding enhanced green fluorescent protein (EGFP flanked by loxP sites. Viruses expressing EGFP were then screened for and purified by serial plaque formation. In a second step the marker EGFP gene was removed by transfecting cells with a plasmid encoding cre recombinase and selecting for viruses that had lost the EGFP phenotype. The MVTT3 mutant was shown to be avirulent and immunogenic. These results support the conclusion that TC7L-TK2L and TA35R deletion mutants can be used as safe viral vectors or as platform for vaccines.

  4. Attenuation of Vaccinia Tian Tan Strain by Removal of Viral TC7L-TK2L and TA35R Genes

    Science.gov (United States)

    Kan, Shifu; Wang, Yuhang; Sun, Lili; Jia, Peng; Qi, Yanxin; Su, Jiaqiang; Liu, Lei; Yang, Guohua; Liu, Liming; Wang, Zhuoyue; Wang, Jinhui; Liu, Guangchen; Jin, Ningyi; Li, Xiao; Ding, Zhuang

    2012-01-01

    Vaccinia Tian Tan (VTT) was attenuated by deletion of the TC7L-TK2L and TA35R genes to generate MVTT3. The mutant was generated by replacing the open reading frames by a gene encoding enhanced green fluorescent protein (EGFP) flanked by loxP sites. Viruses expressing EGFP were then screened for and purified by serial plaque formation. In a second step the marker EGFP gene was removed by transfecting cells with a plasmid encoding cre recombinase and selecting for viruses that had lost the EGFP phenotype. The MVTT3 mutant was shown to be avirulent and immunogenic. These results support the conclusion that TC7L-TK2L and TA35R deletion mutants can be used as safe viral vectors or as platform for vaccines. PMID:22363781

  5. Theoretical Study on the C-H Activation in Decarbonylation of Acetaldehyde by NiL2 (L=SO3CH3) Using Density Functional Theory

    Institute of Scientific and Technical Information of China (English)

    LIU Hongfei; JIA Tiekun; MIN Xinmin

    2014-01-01

    Density functional theory calculations were carried out to explore the potential energy surface (PES) associated with the gas-phase reaction of NiL2(L=SO3CH3) with acetone. The geometries and energies of the reactants, intermediates, products and transition states of the triplet ground potential energy surfaces of [Ni, O, C2, H4] were obtained at the B3LYP/6-311++G(d,p) levels in C,H,O atoms and B3LYP/Lanl2dz in Ni atom. It was found through our calculations that the decabonylation of acetaldehyde contains four steps including encounter complexation, C-C activation, aldehyde H-shift and nonreactive dissociation. The results revealed that C-C activation induced by NiL2(L=SO3CH3) led to the decarbonylation of acetaldehyde.

  6. Finite element thermal analysis for PMMA/st.st.304 laser direct joining

    Science.gov (United States)

    Hussein, Furat I.; Salloomi, Kareem N.; Akman, E.; Hajim, K. I.; Demir, A.

    2017-01-01

    This work is concerned with building a three-dimensional (3D) ab-initio models that is capable of predicting the thermal distribution of laser direct joining processes between Polymethylmethacrylate (PMMA) and stainless steel 304(st.st.304). ANSYS® simulation based on finite element analysis (FEA) was implemented for materials joining in two modes; laser transmission joining (LTJ) and conduction joining (CJ). ANSYS® simulator was used to explore the thermal environment of the joints during joining (heating time) and after joining (cooling time). For both modes, the investigation is carried out when the laser spot is at the middle of the joint width, at 15 mm from the commencement point (joint edge) at traveling time of 3.75 s. Process parameters involving peak power (Pp=3 kW), pulse duration (τ=5 ms), pulse repetition rate (PRR=20 Hz) and scanning speed (v=4 mm/s) are applied for both modes.

  7. 38 CFR 3.851 - St. Elizabeths Hospital, Washington, DC.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false St. Elizabeths Hospital, Washington, DC. 3.851 Section 3.851 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS... Institutional Awards § 3.851 St. Elizabeths Hospital, Washington, DC. Benefits due or becoming due any...

  8. Tracing the Evolution of Florida's St. Vincent Island

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This is a history of St. Vincent Island, up to the year that it was bought by the U.S. Fish and Wildlife Service. St. Vincent Island is a natural barrier island...

  9. Old Money: Economic History of St. Augustine. Lesson Plan.

    Science.gov (United States)

    Glaser, Tom W.

    To better understand the economic aspects of early Florida and to gain an understanding of the continuity of history and economics, students analyze the economic origins and evolution of St. Augustine, Florida, the oldest city in the United States. This lesson plan involves taking the students on a field trip to St. Augustine where they form teams…

  10. Chemistry of St. John's Wort: Hypericin and Hyperforin

    Science.gov (United States)

    Vollmer, John J.; Rosenson, Jon

    2004-01-01

    The appeal as natural antidepressant is the major selling point of St. John's Wort, which is referred to as "Prozac from the plant kingdom". Hypericin and hyperforin, two major constituents with significant biological activity of St. John's Wort and which are complex molecules with unusual features, are examined.

  11. Combined cardiotocographic and ST event analysis : A review

    NARCIS (Netherlands)

    Amer-Wahlin, Isis; Kwee, Anneke

    2016-01-01

    ST-analysis of the fetal electrocardiogram (ECG) (STAN®) combined with cardiotocography (CTG) for intrapartum fetal monitoring has been developed following many years of animal research. Changes in the ST-segment of the fetal ECG correlated with fetal hypoxia occurring during labor. In 1993 the

  12. Escherichia coli ST131, an Intriguing Clonal Group

    Science.gov (United States)

    Bertrand, Xavier; Madec, Jean-Yves

    2014-01-01

    SUMMARY In 2008, a previously unknown Escherichia coli clonal group, sequence type 131 (ST131), was identified on three continents. Today, ST131 is the predominant E. coli lineage among extraintestinal pathogenic E. coli (ExPEC) isolates worldwide. Retrospective studies have suggested that it may originally have risen to prominence as early as 2003. Unlike other classical group B2 ExPEC isolates, ST131 isolates are commonly reported to produce extended-spectrum β-lactamases, such as CTX-M-15, and almost all are resistant to fluoroquinolones. Moreover, ST131 E. coli isolates are considered to be truly pathogenic, due to the spectrum of infections they cause in both community and hospital settings and the large number of virulence-associated genes they contain. ST131 isolates therefore seem to contradict the widely held view that high levels of antimicrobial resistance are necessarily associated with a fitness cost leading to a decrease in pathogenesis. Six years after the first description of E. coli ST131, this review outlines the principal traits of ST131 clonal group isolates, based on the growing body of published data, and highlights what is currently known and what we need to find out to provide public health authorities with better information to help combat ST131. PMID:24982321

  13. On generalized Powers-St$\\o$rmer's Inequality

    CERN Document Server

    Hoa, Dinh Trung; Toan, Ho Minh

    2012-01-01

    A generalization of Powers-St$\\o$rmer's inequality for operator monotone functions on $[0, +\\infty)$ and for positive linear functional on general $C^*$-algebras will be proved. It also will be shown that the generalized Powers-St$\\o$rmer inequality characterizes the tracial functionals on $C^*$-algebras.

  14. Orthophoto Mosaic (2012) of the St. Thomas East End Reserve

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 0.3x0.3 meter imagery mosaic of the St. Thomas East End Reserve (STEER), St. Thomas in the U.S. Virgin Islands was created by the National Oceanic and...

  15. Bathymetry (2011) of the St. Thomas East End Reserve

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 0.3x0.3 meter resolution depth surface for the St. Thomas East End Reserve (STEER), St. Thomas in the...

  16. Smart Social Networking: 21st Century Teaching and Learning Skills

    Science.gov (United States)

    Boholano, Helen B.

    2017-01-01

    Education in the 21st century highlights globalization and internationalization. Pre-service teachers in the 21st century are technology savvy. To effectively engage and teach generation Z students, preservice teachers will help the educational system meet this requirement. The educational systems must be outfitted with a prerequisite of ICT…

  17. 33 CFR 117.653 - St. Mary's Falls Canal.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false St. Mary's Falls Canal. 117.653 Section 117.653 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Michigan § 117.653 St. Mary's Falls Canal. The draw...

  18. Energirenovering af større bygninger - metode og proces

    DEFF Research Database (Denmark)

    Mortensen, Lone Hedegaard; Laustsen, Jacob Birck; Vorre, Mette Havgaard

    ​SBi-anvisning 269 omhandler metode og proces for gennemførelse af energirenoveringsprojekter for større bygninger fra idefase til driftsfase. Større bygninger omfatter etageboliger, bygninger til privat handel- og service samt offentlige institutioner. Anvisningen giver vejledning for de...

  19. A Cultural Resources Survey of the St. Charles Parish Hurricane Protection Levee, St. Charles Parish, Louisiana

    Science.gov (United States)

    1988-09-01

    Destrehan, daughter of Jean-Noel Destrehan and Marie-Claude Elenore de Longy (Conrad 1981:87). 69 .... .. mu muuuu m umuum 0n By 1944 the plantation was in...National Historic Park . Southwest Cultural Resources Center, Santa Fe. Holmes, Jack D. 1967 Indigo in Colonial Louisiana and the Floridas; Louisiana HiSt...Report submitted to the National Park Service, Tallahassee. 79 Neuman, Robert W. 1977 An Archaeological Assessment of Coastal Louisiana. Melanges, No

  20. Response of SCP-2L domain of human MFE-2 to ligand removal: binding site closure and burial of peroxisomal targeting signal.

    Science.gov (United States)

    Lensink, M F; Haapalainen, A M; Hiltunen, J K; Glumoff, T; Juffer, A H

    2002-10-11

    In the study of the structure and function relationship of human MFE-2, we have investigated the dynamics of human MFE-2SCP-2L (hSCP-2L) and its response to ligand removal. A comparison was made with homologous rabbit SCP-2. Breathing and a closing motion are found, identifiable with an adjustment in size and a closing off of the binding pocket. Crucial residues for structural integrity have been identified. Particularly mobile areas of the protein are loop 1 that is connecting helices A and C in space, and helix D, next to the entrance of the pocket. In hSCP-2L, the binding pocket gets occupied by Phe93, which is making a tight hydrophobic contact with Trp36. In addition, it is found that the C-terminal peroxisomal targeting signal (PTS1) that is solvent exposed in the complexed structure becomes buried when no ligand is present. Moreover, an anti-correlation exists between burial of PTS1 and the size of the binding pocket. The results are in accordance with plant nsLTPs, where a similar accommodation of binding pocket size was found after ligand binding/removal. Furthermore, the calculations support the suggestion of a ligand-assisted targeting mechanism.

  1. Investigation of the complex I assembly chaperones B17.2L and NDUFAF1 in a cohort of CI deficient patients.

    Science.gov (United States)

    Vogel, Rutger O; van den Brand, Mariël A M; Rodenburg, Richard J; van den Heuvel, Lambert P W J; Tsuneoka, Makoto; Smeitink, Jan A M; Nijtmans, Leo G J

    2007-06-01

    Dysfunction of complex I (NADH:ubiquinone oxidoreductase; CI), the largest enzyme of the oxidative phosphorylation (OXPHOS) system, often results in severe neuromuscular disorders and early childhood death. Mutations in its seven mitochondrial and 38 nuclear DNA-encoded structural components can only partly explain these deficiencies. Recently, CI assembly chaperones NDUFAF1 and B17.2L were linked to CI deficiency, but it is still unclear by which mechanism. To better understand their requirement during assembly we have studied their presence in CI subcomplexes in a cohort of CI deficient patients using one- and two-dimensional blue-native PAGE. This analysis revealed distinct differences between their associations to subcomplexes in different patients. B17.2L occurred in a 830 kDa subcomplex specifically in patients with mutations in subunits NDUFV1 and NDUFS4. Contrasting with this seemingly specific requirement, the previously described NDUFAF1 association to 500-850 kDa intermediates did not appear to be related to the nature and severity of the CI assembly defect. Surprisingly, even in the absence of assembly intermediates in a patient harboring a mutation in translation elongation factor G1 (EFG1), NDUFAF1 remained associated to the 500-850 kDa subcomplexes. These findings illustrate the difference in mechanism between B17.2L and NDUFAF1 and suggest that the involvement of NDUFAF1 in the assembly process could be indirect rather than direct via the binding to assembly intermediates.

  2. Influx-Operated Ca2+ Entry via PKD2-L1 and PKD1-L3 Channels Facilitates Sensory Responses to Polymodal Transient Stimuli

    Directory of Open Access Journals (Sweden)

    Mingfeng Hu

    2015-10-01

    Full Text Available The polycystic TRP subfamily member PKD2-L1, in complex with PKD1-L3, is involved in physiological responses to diverse stimuli. A major challenge to understanding whether and how PKD2-L1/PKD1-L3 acts as a bona fide molecular transducer is that recombinant channels usually respond with small or undetectable currents. Here, we discover a type of Ca2+ influx-operated Ca2+ entry (ICE that generates pronounced Ca2+ spikes. Triggered by rapid onset/offset of Ca2+, voltage, or acid stimuli, Ca2+-dependent activation amplifies a small Ca2+ influx via the channel. Ca2+ concurrently drives a self-limiting negative feedback (Ca2+-dependent inactivation that is regulated by the Ca2+-binding EF hands of PKD2-L1. Our results suggest a biphasic ICE with opposite Ca2+ feedback regulation that facilitates sensory responses to multimodal transient stimuli. We suggest that such a mechanism may also occur for other sensory modalities and other Ca2+ channels.

  3. St. Louis Airport site environmental report for calendar year 1989, St. Louis, Missouri

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1990-05-01

    The environmental monitoring program, which began in 1984, continued during 1989 at the St. Louis Airport Site (SLAPS) in St. Louis County, Missouri. SLAPS and its vicinity properties, including ditches north and south of the site, were designated for cleanup as part of the Formerly Utilized Sites Remedial Action Program (FUSRAP), a United States Department of Energy (DOE) program to identify and decontaminate or otherwise control sites where residual radioactive material remains from the early years of the nation's atomic energy program. The monitoring program at SLAPS measures radon concentrations in air; external gamma dose rates; and uranium, thorium, and radium concentrations in surface water, groundwater, and sediment. Additionally, several nonradiological parameters are measured in groundwater. To assess the potential effect of SLAPS on public health, the potential radiation dose was estimated for a hypothetical maximally exposed individual. This report presents the findings of the environmental monitoring program conducted at the St. Louis Airport Site (SLAPS) during calendar year 1989. 19 refs., 13 figs., 14 tabs.

  4. The First Outbreak Caused by Acinetobacter baumannii ST208 and ST195 in China

    Directory of Open Access Journals (Sweden)

    Junyan Qu

    2016-01-01

    Full Text Available This study aimed to analyze the clinical characteristics of patients and molecular mechanisms of the first outbreak mainly caused by sequence types (STs 208 multidrug resistant (MDR Acinetobacter baumannii in China. A total of 10 clinical samples were collected from 5 patients who were involved in the outbreak. Bacterial identification and antibiotic sensitivity tests were performed by the VITEK-2 COMPACT automated system. MICs of tigecycline for clinical isolates were determined using broth microdilution. The clonal relatedness of A. baumannii clinical isolates in our local settings was determinated by pulsed-field gel electrophoresis (PFGE and multilocus sequence typing (MLST. A total of 7 A. baumannii strains were isolated and all were MDR strains; two of them were carbapenem-nonsusceptible strains. blaOXA-23 was the only acquired carbapenemase gene in the isolates. The isolates belonged to a single clonal pulsotype determined by PFGE and two sequences types (STs determined by MLST. The isolates belonged to the globally disseminated clonal complex 92, among which ST195 and ST208 were the most common sequence types (71.43% and 28.57%. The outbreak was successfully controlled by stringent infection control measures, especially improving the hand hygiene compliance and enhancing antimicrobial stewardship. In conclusion, this is the first description of an outbreak caused mainly by A. baumannii of ST208 in China. Infection control measures should be strengthened when infection outbreaks in hospital.

  5. ST2 IN REJECTION OF THE TRANSPLANTED HEART

    Directory of Open Access Journals (Sweden)

    O. P. Shevchenko

    2015-01-01

    Full Text Available This review summarizes the current literature devoted to the analysis of prognostic role of ST2 biomarker in rejection of the transplanted heart. ST2 is one of the most promising diagnostic markers of the development and severity of heart failure as well as the mortality risk in patients with cardiovascular diseases. ST2 is expressed in cardiomyocytes in response to a variety of pathological processes and mechanical damage to the heart, which allows diagnosing cardiovascular diseases before clinical manifestations. Presumably, measuring the level of ST2 in heart transplant may have diagnostic and prognostic value in the assessment of graft and risk of rejection. Currently, accumulated clinical data on the role of given biomarker in heart transplantation are not enough, and further research on the relation of ST2 levels with different clinical and laboratory parameters in heart recipients is necessary. 

  6. Postoperative volume balance

    DEFF Research Database (Denmark)

    Frost, H; Mortensen, C.R.; Secher, Niels H.

    2017-01-01

    In healthy humans, stroke volume (SV) and cardiac output (CO) do not increase with expansion of the central blood volume by head-down tilt or administration of fluid. Here, we exposed 85 patients to Trendelenburg's position about one hour after surgery while cardiovascular variables were determined...... non-invasively by Modelflow. In Trendelenburg's position, SV (83 ± 19 versus 89 ± 20 ml) and CO (6·2 ± 1·8 versus 6·8 ± 1·8 l/min; both Pheart rate (75 ± 15 versus 76 ± 14 b min(-1) ) and mean arterial pressure were unaffected (84 ± 15 versus 84 ± 16 mmHg). For the 33 patients......, determination of SV and/or CO in Trendelenburg's position can be used to evaluate whether a patient is in need of IV fluid as here exemplified after surgery....

  7. Select Papers. Volume 1

    Science.gov (United States)

    2011-08-01

    non- uniform rational B-splines (NURBS), 127 and BRL-CAD TM format. This dual-package development allowed for rapid development of components ...next generation of scientists and engineers. A fundamental component of our outreach program is to provide students research experiences at ARL...summer intern. There, I ran Volume Based Morphometry , an application of Statistical Parametric Mapping that was new to the Hirsch lab. I

  8. 1st International Conference on Network Analysis

    CERN Document Server

    Kalyagin, Valery; Pardalos, Panos

    2013-01-01

    This volume contains a selection of contributions from the "First International Conference in Network Analysis," held at the University of Florida, Gainesville, on December 14-16, 2011. The remarkable diversity of fields that take advantage of Network Analysis makes the endeavor of gathering up-to-date material in a single compilation a useful, yet very difficult, task. The purpose of this volume is to overcome this difficulty by collecting the major results found by the participants and combining them in one easily accessible compilation. Network analysis has become a major research topic over the last several years. The broad range of applications that can be described and analyzed by means of a network is bringing together researchers, practitioners and other scientific communities from numerous fields such as Operations Research, Computer Science, Transportation, Energy, Social Sciences, and more. The contributions not only come from different fields, but also cover a broad range of topics relevant to the...

  9. Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258 : a systematic review and meta-analysis

    NARCIS (Netherlands)

    Dautzenberg, M J D; Haverkate, M R; Bonten, M J M; Bootsma, M C J

    2016-01-01

    OBJECTIVES: Observational studies have suggested that Escherichia coli sequence type (ST) 131 and Klebsiella pneumoniae ST258 have hyperendemic properties. This would be obvious from continuously high incidence and/or prevalence of carriage or infection with these bacteria in specific patient popula

  10. Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258 : A systematic review and meta-analysis

    NARCIS (Netherlands)

    Dautzenberg, M. J D|info:eu-repo/dai/nl/357298969; Haverkate, M. R.; Bonten, M. J M|info:eu-repo/dai/nl/123144337; Bootsma, M. C J

    2016-01-01

    Objectives: Observational studies have suggested that Escherichia coli sequence type (ST) 131 and Klebsiella pneumoniae ST258 have hyperendemic properties. This would be obvious from continuously high incidence and/or prevalence of carriage or infection with these bacteria in specific patient

  11. Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258 : a systematic review and meta-analysis

    NARCIS (Netherlands)

    Dautzenberg, M J D; Haverkate, M R; Bonten, M J M; Bootsma, M C J

    2016-01-01

    OBJECTIVES: Observational studies have suggested that Escherichia coli sequence type (ST) 131 and Klebsiella pneumoniae ST258 have hyperendemic properties. This would be obvious from continuously high incidence and/or prevalence of carriage or infection with these bacteria in specific patient

  12. Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258 : a systematic review and meta-analysis

    NARCIS (Netherlands)

    Dautzenberg, M J D; Haverkate, M R; Bonten, M J M; Bootsma, M C J|info:eu-repo/dai/nl/304830305

    2016-01-01

    OBJECTIVES: Observational studies have suggested that Escherichia coli sequence type (ST) 131 and Klebsiella pneumoniae ST258 have hyperendemic properties. This would be obvious from continuously high incidence and/or prevalence of carriage or infection with these bacteria in specific patient popula

  13. Identification and characterization of two novel cytosolic sulfotransferases, SULT1 ST7 and SULT1 ST8, from zebrafish

    Energy Technology Data Exchange (ETDEWEB)

    Liu, T.-A. [Department of Pharmacology, College of Pharmacy, University of Toledo, Toledo, OH 43606 (United States); Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan (China); Bhuiyan, Shakhawat [Division of Arts and Sciences, Jarvis Christian College, Hawkins, TX 75765 (United States); Snow, Rhodora [School of Mathematics and Science, J. Sargeant Reynolds Community College, Richmond, VA 23285 (United States); Yasuda, Shin; Yasuda, Tomoko [Department of Pharmacology, College of Pharmacy, University of Toledo, Toledo, OH 43606 (United States); Yang, Y.-S. [Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan (China); Williams, Frederick E.; Liu, M.-Y.; Suiko, Masahito [Department of Pharmacology, College of Pharmacy, University of Toledo, Toledo, OH 43606 (United States); Carter, Glendora [School of Mathematics and Science, J. Sargeant Reynolds Community College, Richmond, VA 23285 (United States); Liu, M.-C. [Department of Pharmacology, College of Pharmacy, University of Toledo, Toledo, OH 43606 (United States)], E-mail: ming.liu@utoledo.edu

    2008-08-29

    Cytosolic sulfotransferases (SULTs) constitute a family of Phase II detoxification enzymes that are involved in the protection against potentially harmful xenobiotics as well as the regulation and homeostasis of endogenous compounds. Compared with humans and rodents, the zebrafish serves as an excellent model for studying the role of SULTs in the detoxification of environmental pollutants including environmental estrogens. By searching the expressed sequence tag database, two zebrafish cDNAs encoding putative SULTs were identified. Sequence analysis indicated that these two putative zebrafish SULTs belong to the SULT1 gene family. The recombinant form of these two novel zebrafish SULTs, designated SULT1 ST7 and SULT1 ST8, were expressed using the pGEX-2TK glutathione S-transferase (GST) gene fusion system and purified from transformed BL21 (DE3) cells. Purified GST-fusion protein form of SULT1 ST7 and SULT1 ST8 exhibited strong sulfating activities toward environmental estrogens, particularly hydroxylated polychlorinated biphenyls (PCBs), among various endogenous and xenobiotic compounds tested as substrates. pH-dependence experiments showed that SULT1 ST7 and SULT1 ST8 displayed pH optima at 6.5 and 8.0, respectively. Kinetic parameters of the two enzymes in catalyzing the sulfation of catechin and chlorogenic acid as well as 3-chloro-4-biphenylol were determined. Developmental expression experiments revealed distinct patterns of expression of SULT1 ST7 and SULT1 ST8 during embryonic development and throughout the larval stage onto maturity.

  14. St. Finbarr's Hospital, Douglas Road, Cork.

    LENUS (Irish Health Repository)

    Vaughan, Denis

    2012-02-27

    Spinal arachnoiditis describes inflammation of the meninges, subarachnoid space and, in most cases, also involve the pial layer. The vast majority of cases described are secondary and are preceded by a known event, for example,. trauma, infections or irritative substances. Here, we present the case of primary spinal arachnoiditis. A 35-year-old lady was referred to the neurosurgical services in Dublin, Ireland with a 15-month history of progressive, right lower limb weakness. Magnetic resonance imaging revealed cystic distortion of the lumbar spinal canal extending up to the conus. Initially, an L2-L4 laminectomy was performed revealing thickened and adherent arachnoid with a large cyst in the spinal canal. Four months after initial operation, the patient represented with bilateral lower limb weakness and loss of detrusor function. Repeat magnetic resonance imaging was performed, which showed the development of a syrinx in the patient\\'s thoracic spine. We then performed a T9-T10 laminectomy, midline myelotomy and insertion of a syringe-arachnoid shunt. Post-operative imaging showed resolution of the syrinx and a vast improvement in lower limb power. The patient also regained bladder control. In conclusion, spinal arachnoiditis is a clearly defined pathological and radiological entity with a highly variable clinical presentation. It is exceedingly difficult to treat as there is no recognised treatment currently, with most interventions aimed at symptomatic relief.

  15. Environmental Report 1996, Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Harrach, R.J.

    1996-01-01

    This is Volume 2 of the Lawrence Livermore National Laboratory`s (LLNL`s) annual Environmental Report 1996, prepared for the US Department of Energy. Volume 2 supports Volume 1 summary data and is essentially a detailed data report that provides individual data points, where applicable. Volume 2 includes information on monitoring of air, air effluents, sewerable water, surface water, ground water, soil and sediment, vegetation and foodstuff, environmental radiation, and quality assurance.

  16. Predictive factors predicting inadequate ST-segment resolution in patients with acute ST-segment elevation myocardial infarction after percutaneous coronary intervention

    Institute of Scientific and Technical Information of China (English)

    刘晓宇

    2014-01-01

    Objective To survey ST-segment resolution in STEMI patients undergoing emergency percutaneous coronary intervention(PCI)and to find the specific clinical features of patients with inadequate ST-segment resolution.Methods A total of 198 patients were divided into two groups according to the ratio of ST-segment resolution:relatively adequate ST-segment resolution group(>50%)and inadequate ST-segment resolution group(<50%).

  17. Phenotypic variation in Blastocystis sp. ST3.

    Science.gov (United States)

    Ragavan, Nanthiney Devi; Govind, Suresh Kumar; Chye, Tan Tian; Mahadeva, Sanjiv

    2014-08-29

    Blastocystis, is one of the most common human intestinal protozoan, which has many conflicting reports on its pathogenic role. Gut conditions which obviously varies in asymptomatic individuals, symptomatic and irritable bowel syndrome (IBS) patients in terms of gut flora, pH, osmotic pressure and water potentials could play an important role in its pathogenicity. The present study is the first study to investigate phenotypic characteristics of Blastocystis sp. ST3 isolated from asymptomatic, symptomatic and IBS isolates. A total of 8 Blastocystis isolates were obtained from four IBS patients (IBS1-4) and four symptomatic patients (S1-4) at a local gastroenterology clinic. Asymptomatic isolates (A1-4) were obtained from a field survey at a local village. All 12 isolates were determined as subtype 3 (ST3). A1-4 isolates showed the highest peak growth followed by IBS1-4 isolates and S1-4 isolates for the growth profile. Parasites from IBS isolates (IBS1-4) showed the largest diameter with a mean 18.43 ± 2.22 μm compared to parasites of symptomatic isolates (isolates S1-4) 15.54 ± 3.02 μm and asymptomatic isolates (isolates A1-4) 11.76 ± 0.82 μm. The symptomatic isolates (average generation time: 9.87 ± 2.97 h) grew faster than the IBS isolates (average generation time: 7.56 ± 1.06 h) and asymptomatic isolates (average generation time: 5.97 ± 1.52 h). The parasites isolated from IBS isolates showed strong aggregation and clumping, which had seen reduced in parasites of isolates S1-4. No clumping was seen in parasites from A1-4. The outer surface of parasites in IBS isolates showed greater binding affinities towards FITC-labelled Concanavalin A (Con A) than symptomatic isolates and asymptomatic isolates. Scanning electron microscopy showed that in IBS isolates, the surface of Blastocystis showed a very coarse and intensely folded surface. The IBS isolates also exhibited a dense material and a thicker layer of surface coat can be seen compared to asymptomatic

  18. Fruit-specific gene expression of ZmBK2 L3 in tomato and its function%ZmB K2 L3在番茄果实中的特异表达及其功能研究

    Institute of Scientific and Technical Information of China (English)

    杨潇怡; 隋媛; 唐晓凤; 曹徐绿; 岳俊阳; 刘永胜

    2016-01-01

    Fruit-specific overexpression vector of maize BK2L3 was constructed to investigate the effect of gene engineering on fruit firmness and shelf life .The full-length cDNA sequence of maize Zm-BK2L3 gene was amplified by reverse transcription polymerase chain reaction (RT-PCR) and pBI121-BK2L3 overexpression construction driven by a fruit-specific promoter TFM7 was made to generate Agrobacerium mediated tomato transformants .In view of the transgenic tomatoes and the wild type tomatoes ,the BK2L3 expression in the fruit was analyzed ,the pericarp cell wall structure of fruit at green ripe stage was observed ,and the firmness ,cellulose content and shelf life of fruit at red ripe stage were determined .The result of molecular analysis demonstrated a significant increase of BK2L3 expression in the transgenic tomatoes .The positive transgenic tomatoes displayed enhanced pericarp thickness .The firmness ,cellulose content and shelf life of the transgenic red ripe fruits were higher than those of the wild type species .These results demonstrated that fruit-specific overexpression of maize BK2L3 in tomato could improve fruit quality in terms of cell wall metabolism and shelf life .%文章通过构建玉米 BK2L3基因果实特异表达的过量表达载体,对转基因番茄果实进行研究,实现以基因工程手段延长番茄果实货架期的目的。利用逆转录聚合酶链式反应(reverse transcription polymerase chain reaction ,RT-PCR)技术从玉米cDNA中扩增出 ZmBK2L3基因全长,导入启动子为果实特异表达的T FM 7植物表达载体pBI121上,经农杆菌介导转入野生型番茄中,获得转基因阳性植株。分别以野生型番茄和转基因番茄为材料,分析 BK2L3在果实中的表达情况,观察绿熟期果实果皮细胞壁结构,测定红熟期果实的硬度、货架期和果皮纤维素质量比。结果表明:转基因番茄果实中 BK2L3的表达量明显高于野生型果实。转基因番茄果

  19. REFLECTION AND REFRACTION, VOLUME 2.

    Science.gov (United States)

    KLAUS, DAVID J.; AND OTHERS

    THIS VOLUME 2 OF A TWO-VOLUME SET PROVIDES AUTOINSTRUCTION IN PHYSICS. THE UNITS COVERED IN THIS VOLUME ARE (1) REFLECTION OF LIGHT, (2) PHOTOMETRY, (3) POLARIZATION, (4) REFRACTION OF LIGHT, (5) SNELL'S LAW, (6) LENSES, FOCUS, AND FOCAL POINTS, (7) IMAGE FORMATION, AND (8) ABERRATIONS, THE EYE, AND MAGNIFICATION. THE INTRODUCTION AND UNITS ON…

  20. Calculus Students' Understanding of Volume

    Science.gov (United States)

    Dorko, Allison; Speer, Natasha M.

    2013-01-01

    Researchers have documented difficulties that elementary school students have in understanding volume. Despite its importance in higher mathematics, we know little about college students' understanding of volume. This study investigated calculus students' understanding of volume. Clinical interview transcripts and written responses to volume…

  1. 80-Myr history of buoyancy and volcanic fluxes along the trails of the Walvis and St. Helena hotspots (South Atlantic)

    Science.gov (United States)

    Vidal, V.; Adam, C.; Escartin, J.

    2007-12-01

    Walvis and St.~Helena are the only long-lived hotspot chains in the South Atlantic. Therefore, their characterization is important to constrain the processes associated with mantle plume formation, their temporal evolution, and the interaction with plate and mantle dynamics in the region. We study the temporal evolution of plume buoyancy and magma production rate along both hotspot chains, which are constrained from the swell and volume of volcanic materials emplaced along the chain. The regional depth anomaly is calculated by correcting the 2' bathymetry grid of Smith & Sandwell (1997) for thermal subsidence and sediment loading. We separate the topography associated with volcanism and the swell surrounding the hotspot chains using the MiFil filtering method (Adam et al., 2005). We then estimate the temporal variations associated with both parameters by computing volumes along the hotspot tracks. Neither Walvis nor St.~Helena show a 'classical' hotspot behavior. We find that two plumes are at the origin of the St.~Helena chain. This study also shows a swell associated with the Circe seamount, supporting the existence of a hotspot NW of the St.~Helena trail. The variation in swell and volcanic fluxes suggests temporal variability in the plume behavior at time scales of 10-20~m.y. and 5~m.y., which may be related to oscillations and instabilities of the plume conduit, respectively. Cumulative fluxes in the area are largest for Walvis and weakest for Circe, and all are significantly lower than that reported for the Hawai'i hotspot.

  2. Evaluation of ST13 gene expression in colorectal cancer patients

    Institute of Scientific and Technical Information of China (English)

    DONG Qing-hua; ZHENG Shu; HU Yue; CHEN Gong-xing; DING Jia-yi

    2005-01-01

    We identified a novel gene ST13 from a subtractive cDNA library of normal intestinal mucosa in 1993, more studies showed that ST13 was a co-chaperone of Hsp70s. Recently we detected the ST13 gene expression in tumor tissue and adjacent normal tissue of the same colorectal cancer patient and investigated ifthe ST13 gene expression might have any prognostic value.Analysis was performed at molecular level by reverse transcfiption-PCR using real-time detection method. We measured two genes simultaneously, ST13 as the target gene and glyceraldehydes-3-phosphate dehydrogenase as a reference gene, in primary colorectal tumor specimens and tumor-adjacent normal mucosa specimens from 50 colorectal cancer patients. The expression levels of the ST13 gene were significantly decreased in primary tumors compared with adjacent mucosa (P<0.05). But there were no significant differences in the expression of ST13 as compared with different Dukes' stage, tumor differentiation grade, invasion depth, lymph node metastasis and disease-specific survival.

  3. Combined cardiotocographic and ST event analysis: A review.

    Science.gov (United States)

    Amer-Wahlin, Isis; Kwee, Anneke

    2016-01-01

    ST-analysis of the fetal electrocardiogram (ECG) (STAN(®)) combined with cardiotocography (CTG) for intrapartum fetal monitoring has been developed following many years of animal research. Changes in the ST-segment of the fetal ECG correlated with fetal hypoxia occurring during labor. In 1993 the first randomized controlled trial (RCT), comparing CTG with CTG + ST-analysis was published. STAN(®) was introduced for daily practice in 2000. To date, six RCTs have been performed, out of which five have been published. Furthermore, there are six published meta-analyses. The meta-analyses showed that CTG + ST-analysis reduced the risks of vaginal operative delivery by about 10% and fetal blood sampling by 40%. There are conflicting results regarding the effect on metabolic acidosis, much because of controveries about which RCTs should be included in a meta-analysis, and because of differences in methodology, execution and quality of the meta-analyses. Several cohort studies have been published, some showing significant decrease of metabolic acidosis after the introduction of ST-analysis. In this review, we discuss not only the scientific evidence from the RCTs and meta-analyses, but also the limitations of these studies. In conclusion, ST-analysis is effective in reducing operative vaginal deliveries and fetal blood sampling but the effect on neonatal metabolic acidosis is still under debate. Further research is needed to determine the place of ST-analysis in the labor ward for daily practice.

  4. Vaccines for the 21st century

    Science.gov (United States)

    Delany, Isabel; Rappuoli, Rino; De Gregorio, Ennio

    2014-01-01

    In the last century, vaccination has been the most effective medical intervention to reduce death and morbidity caused by infectious diseases. It is believed that vaccines save at least 2–3 million lives per year worldwide. Smallpox has been eradicated and polio has almost disappeared worldwide through global vaccine campaigns. Most of the viral and bacterial infections that traditionally affected children have been drastically reduced thanks to national immunization programs in developed countries. However, many diseases are not yet preventable by vaccination, and vaccines have not been fully exploited for target populations such as elderly and pregnant women. This review focuses on the state of the art of recent clinical trials of vaccines for major unmet medical needs such as HIV, malaria, TB, and cancer. In addition, we describe the innovative technologies currently used in vaccine research and development including adjuvants, vectors, nucleic acid vaccines, and structure-based antigen design. The hope is that thanks to these technologies, more diseases will be addressed in the 21st century by novel preventative and therapeutic vaccines. PMID:24803000

  5. ST-HM not only cranes

    CERN Document Server

    Bertone, C

    2002-01-01

    This period of LEP dismantling and LHC installation is a real challenge for the ST-HM group. The group is now following several projects to cope with the diversity of requests. Although crane design and procurement still constitutes the majority of the workload, more and more of our time is nowadays dedicated to providing alternative handling solutions. In 2001/2002, our main studies concern cranes for LHC, industrial and shielded motorised doors, the upgrade/replacement of 32 lifts and mobile cranes. The years 2002/2003 will concern mainly the study of LHC handling systems such as trailers and heavy-duty tractors, specifically tailored containers and tools. In parallel, the monorail will be extended in the injection tunnel and CNGS tunnels and a new monorail system for TOF will be installed. Since the tunnel monorail infrastructure will be used for power feed and guidance purposes only, this requires that other transport systems be studied, such as forklift trucks, industrial and telescopic hoists.

  6. Biofabrication: a 21st century manufacturing paradigm

    Energy Technology Data Exchange (ETDEWEB)

    Mironov, V; Trusk, T; Markwald, R [Medical University of South Carolina, Charleston, SC 29425 (United States); Kasyanov, V [Riga Stradins University, Riga (Latvia); Little, S [South Carolina EPSCoR/IDeA Program, Columbia, SC (United States); Swaja, R [South Carolina Bioengineering Alliance, Charleston, SC 29425 (United States)

    2009-06-01

    Biofabrication can be defined as the production of complex living and non-living biological products from raw materials such as living cells, molecules, extracellular matrices, and biomaterials. Cell and developmental biology, biomaterials science, and mechanical engineering are the main disciplines contributing to the emergence of biofabrication technology. The industrial potential of biofabrication technology is far beyond the traditional medically oriented tissue engineering and organ printing and, in the short term, it is essential for developing potentially highly predictive human cell- and tissue-based technologies for drug discovery, drug toxicity, environmental toxicology assays, and complex in vitro models of human development and diseases. In the long term, biofabrication can also contribute to the development of novel biotechnologies for sustainable energy production in the future biofuel industry and dramatically transform traditional animal-based agriculture by inventing 'animal-free' food, leather, and fur products. Thus, the broad spectrum of potential applications and rapidly growing arsenal of biofabrication methods strongly suggests that biofabrication can become a dominant technological platform and new paradigm for 21st century manufacturing. The main objectives of this review are defining biofabrication, outlining the most essential disciplines critical for emergence of this field, analysis of the evolving arsenal of biofabrication technologies and their potential practical applications, as well as a discussion of the common challenges being faced by biofabrication technologies, and the necessary conditions for the development of a global biofabrication research community and commercially successful biofabrication industry. (topical review)

  7. Science for the 21st Century

    Energy Technology Data Exchange (ETDEWEB)

    2004-07-01

    The Federal government plays a key role in supporting the country's science infrastructure, a national treasure, and scientific research, an investment in our future. Scientific discoveries transform the way we think about our universe and ourselves, from the vastness of space to molecular-level biology. In innovations such as drugs derived through biotechnology and new communications technologies we see constant evidence of the power of science to improve lives and address national challenges. We had not yet learned to fly at the dawn of the 20th century, and could not have imagined the amazing 20th century inventions that we now take for granted. As we move into the 21st century, we eagerly anticipate new insights, discoveries, and technologies that will inspire and enrich us for many decades to come. This report presents the critical responsibilities of our Federal science enterprise and the actions taken by the Federal research agencies, through the National Science and Technology Council, to align our programs with scientific opportunity and with national needs. The many examples show how our science enterprise has responded to the President's priorities for homeland and national security, economic growth, health research, and the environment. In addition, we show how the science agencies work together to set priorities; coordinate related research programs; leverage investments to promote discovery, translate science into national benefits, and sustain the national research enterprise; and promote excellence in math and science education and work force development.

  8. Volume of an Industrial Autoclave

    Directory of Open Access Journals (Sweden)

    Nicholas Madaffari

    2010-01-01

    Full Text Available We were able to determine the volume of an industrial autoclave sterilization tank using a technique learned in calculus. By measuring the dimensions of the tank and roughly estimating the equation of curvature at the ends of the tank, we were able to revolve half of the end of the tank around the x axis to get its fluid volume. Adding the two volumes of the ends and the volume of the cylindrical portion on the tank yielded the total volume.

  9. Using SDI-12 with ST microelectronics MCU's

    Energy Technology Data Exchange (ETDEWEB)

    Saari, Alexandra [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hinzey, Shawn Adrian [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Frigo, Janette Rose [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Proicou, Michael Chris [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Borges, Louis [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-09-03

    ST Microelectronics microcontrollers and processors are readily available, capable and economical processors. Unfortunately they lack a broad user base like similar offerings from Texas Instrument, Atmel, or Microchip. All of these devices could be useful in economical devices for remote sensing applications used with environmental sensing. With the increased need for environmental studies, and limited budgets, flexibility in hardware is very important. To that end, and in an effort to increase open support of ST devices, I am sharing my teams' experience in interfacing a common environmental sensor communication protocol (SDI-12) with ST devices.

  10. S&T strategic planning in light of world development

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ CAS has recently completed a research project on China's S&T strategic planning.More than 300 experts from various S&T disciplines worked diligently for more than a year to produce a blueprint of China's S&T innovation roadmap towards 2050.It covers energy,water resources,mineral resources,marine resources,oil and gas,population and health,agriculture,ecoenvironment,biomass resources,regional development,space,information,advanced manufacturing,advanced materials,nano-science,big science facilities,crossdisciplinary and frontier research,and national security.

  11. Inferior ST-Elevation Myocardial Infarction Associated with Takotsubo Cardiomyopathy

    Directory of Open Access Journals (Sweden)

    Oliver Koeth

    2010-01-01

    Full Text Available Takotsubo cardiomyopathy (TCM is usually characterized by transient left ventricular apical ballooning. Due to the clinical symptoms which include chest pain, electrocardiographic changes, and elevated myocardial markers, Takotsubo cardiomyopathy is frequently mimicking ST-elevation myocardial infarction in the absence of a significant coronary artery disease. Otherwise an acute occlusion of the left anterior descending coronary artery can produce a typical Takotsubo contraction pattern. ST-elevation myocardial infarction (STEMI is frequently associated with emotional stress, but to date no cases of STEMI triggering TCM have been reported. We describe a case of a female patient with inferior ST-elevation myocardial infarction complicated by TCM.

  12. Separable quantizations of Stäckel systems

    Science.gov (United States)

    Błaszak, Maciej; Marciniak, Krzysztof; Domański, Ziemowit

    2016-08-01

    In this article we prove that many Hamiltonian systems that cannot be separably quantized in the classical approach of Robertson and Eisenhart can be separably quantized if we extend the class of admissible quantizations through a suitable choice of Riemann space adapted to the Poisson geometry of the system. Actually, in this article we prove that for every quadratic in momenta Stäckel system (defined on 2 n dimensional Poisson manifold) for which Stäckel matrix consists of monomials in position coordinates there exist infinitely many quantizations-parametrized by n arbitrary functions-that turn this system into a quantum separable Stäckel system.

  13. Inferior ST-Elevation Myocardial Infarction Associated with Takotsubo Cardiomyopathy

    Science.gov (United States)

    Koeth, Oliver; Zeymer, Uwe; Schiele, Rudolf; Zahn, Ralf

    2010-01-01

    Takotsubo cardiomyopathy (TCM) is usually characterized by transient left ventricular apical ballooning. Due to the clinical symptoms which include chest pain, electrocardiographic changes, and elevated myocardial markers, Takotsubo cardiomyopathy is frequently mimicking ST-elevation myocardial infarction in the absence of a significant coronary artery disease. Otherwise an acute occlusion of the left anterior descending coronary artery can produce a typical Takotsubo contraction pattern. ST-elevation myocardial infarction (STEMI) is frequently associated with emotional stress, but to date no cases of STEMI triggering TCM have been reported. We describe a case of a female patient with inferior ST-elevation myocardial infarction complicated by TCM. PMID:20811565

  14. Abschlussbericht zur FAU-Studierendenbefragung : FAU-St 2016

    OpenAIRE

    Schmidt, Christopher; Scherber, Nicole

    2016-01-01

    Der Abschlussbericht und die Tabellenbände dokumentieren die Ergebnisse der FAU-Studierendenbefragung (FAU-St) 2016, die im Januar/Februar des Jahres 2016 durchgeführt wurde. Bei FAU-St handelt es sich um die vollständig überarbeitete und neu ausgerichtete Nachfolgeuntersuchung des FAU-Panels, das seit 2011 jährlich aufgelegt wurde. Die Ergebnisse aus FAU-St 2016 sind eine unersetzliche Basis zur systematischen Weiterentwicklung und Qualitätssicherung an der FAU. Sie werden in allen Gremie...

  15. St. Vicent Ferrer’s Catalán sermon on St. Martin of Tours

    Directory of Open Access Journals (Sweden)

    Ferreiro, Alberto

    2013-12-01

    Full Text Available One of the most widely venerated saints in the Middle Ages was St. Martin of Tours whose cult continues to this day in many parts of the world. In the Middle Ages, he became as popular as other major saints such as Thomas Becket, Santiago de Compostela and the Virgin Mary. St. Martin’s cult became very prominent in the Iberian Peninsula before and after the emergence of the cult of Santiago de Compostela. In St. Vicent Ferrer’s voluminous sermons this one in Catalán is dedicated to this most venerated Gallic saint. The most important late antique and early medieval sources that form the background of this sermon are by Sulpicius Severus- the Gallus and Vita Sancti Martini. In the high Middle Ages, however, his cult was popularized through the Legenda Aurea written by the Dominican Jacobus of Voragine, who synthesized Sulpicius’ two works on St. Martin. Moreover, St. Vicent preached not to make any major doctrinal breakthroughs- his main interest was to evangelize, not to write academic theology- he nevertheless exhibited great creativity. The object of this study is St. Vicent’s Catalán sermon Alius Sermo Sancti Martini, CXXXIV.Uno de los santos más venerados en la edad media fue San Martín de Tours, cuyo culto continúa hasta hoy en muchas partes del mundo. En la edad media, se hizo tan popular como otros grandes Santos: Thomas Becket, Santiago de Compostela y la Virgen María. El culto de San Martín se hizo prominente en la Península Ibérica antes y después de la aparición del culto a Santiago de Compostela. En los sermones voluminosos de San Vicente Ferrer esta uno en Catalán que está dedicado a este santo tan venerado de Galia. Las fuentes más importantes procedentes de la antigu.edad tardía y principios medievales que forma el fondo de este sermón son Gallus y la Vita Sancti Martini de Sulpicio Severo. Sin embargo, en la alta edad media, su culto se popularizó a través de la Legenda Aurea escrita por el dominico

  16. Synthesis and characterization of iron(III), manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) complexes of salicylidene-N-anilinoacetohydrazone (H2L1) and 2-hydroxy-1-naphthylidene-N-anilinoacetohydrazone (H2L2).

    Science.gov (United States)

    AbouEl-Enein, S A; El-Saied, F A; Kasher, T I; El-Wardany, A H

    2007-07-01

    Salicylidene-N-anilinoacetohydrazone (H(2)L(1)) and 2-hydroxy-1-naphthylidene-N-anilinoacetohydrazone (H(2)L(2)) and their iron(III), manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) complexes have been synthesized and characterized by IR, electronic spectra, molar conductivities, magnetic susceptibilities and ESR. Mononuclear complexes are formed with molar ratios of 1:1, 1:2 and 1:3 (M:L). The IR studies reveal various modes of chelation. The electronic absorption spectra and magnetic susceptibility measurements show that the iron(III), nickel(II) and cobalt(II) complexes of H(2)L(1) have octahedral geometry. While the cobalt(II) complexes of H(2)L(2) were separated as tetrahedral structure. The copper(II) complexes have square planar stereochemistry. The ESR parameters of the copper(II) complexes at room temperature were calculated. The g values for copper(II) complexes proved that the Cu-O and Cu-N bonds are of high covalency.

  17. 1st AtMol European Workshop

    CERN Document Server

    Atomic Scale Interconnection Machines

    2012-01-01

    This volume documents the first International Workshop on Atomic Scale Interconnection Machines organised by the European Integrated Project AtMol in June 2011 in Singapore. The four sessions, discussed here in revised contributions by high level speakers, span topics such as: multi-probe UHV instrumentation, atomic scale nano-material nanowires characterization, atomic scale surface conductance measurements and surface atomic scale mechanical machineries. This state-of-the-art account allows academic researchers and industry engineers access to the tools they need to be at the forefront of the atomic scale technology revolution.

  18. Analysis and reconstructed modelling of the debris flow event of the 21st of July 2012 of St. Lorenzen (Styria, Austira)

    Science.gov (United States)

    Janu, Stefan; Mehlhorn, Susanne; Moser, Markus

    2013-04-01

    Analysis and reconstructed modelling of the debris flow event of the 21st of July 2012 of St. Lorenzen (Styria, Austria) Authors: Stefan Janu, Susanne Mehlhorn, Markus Moser The village of St. Lorenzen, in the Styrian Palten valley is situated on the banks of the Lorenz torrent, in which a debris flow event occurred in the early morning hours of the 21st of July 2012, causing catastrophic damage to residential buildings and other infrastructural facilities. In the ministry-approved hazard zone map of 2009, the flood water discharge and bedload volume associated with a 150-year event was estimated at 34 m³/s and 25,000 m³ respectively for the 5.84 km² catchment area. The bedload transport capacity of the torrent was classified as ranging from 'heavy' to 'capable of producing debris flows'. The dominant process type of the mass movement event may be described as a fine-grained debris flow. The damage in the residential area of St.Lorenzen was caused by a debris flow pulse in the lower reach of the Lorenz torrent. This debris flow pulse was in turn caused by numerous landslides along the middle reaches of the torrent, some of which caused blockages, ultimately leading to an outburst event in the main torrent. Discharge cross-sections ranging from 65 - 90 m², and over 100 m² in a few instances, were measured upstream of the St. Lorenzen residential area. Back-calculations of velocities yielded an average debris flow velocity along the middle reaches of the torrent between 11 and 16 m/s. An average velocity of 9 m/s was calculated for the debris flow at the neck of the alluvial fan directly behind the center of the village. Due to both the high discharge values as well as to the height of the mass movement deposits, the natural hazard event of 21 July 2012 in St. Lorenzen is clearly to be described as having had an extreme intensity. A total of 67 buildings were damaged along the Lorenz torrent, 7 of were completely destroyed. According to the Austrian Service for

  19. A study of respiratory rate, tidal volume, inspiratory capacity and inspiratory reserve volume in different trimesters of pregnancy

    Directory of Open Access Journals (Sweden)

    Anita Teli

    2013-01-01

    Full Text Available Background: The anatomical, physiological and biochemical adaptations in pregnancy are profound. Many of these changes begin soon after fertilization and continue throughout the gestation and changes in the respiratory system are part of the same process. However there is insufficient information regarding the changes in respiratory parameters in different trimesters of pregnancy. Aims: The aim of the study was designed to evaluate the pulmonary function tests in 1 st , 2 nd and 3 rd trimesters of pregnancy and compare them with non-pregnant control group. Materials and Methods: A cross-sectional study was carried in 200 healthy women in the age range of 19-35 years. The subjects were distributed in four groups, as control (non-pregnant group and 1 st , 2 nd and 3 rd trimester pregnant groups. Number of subjects in each group was 50. Respiratory parameters in control and study groups were recorded. Statistical Analysis: By ′Z ′ test. Results: There was gradual significant increase in respiratory rate in all trimesters of pregnancy. There was a gradual decrease in tidal volume in 1 st , 2 nd and 3 rd trimesters of pregnancy when compared to non pregnant women. There was significant decrease in Inspiratory Reserve Volume and Inspiratory Capacity. Conclusion: The changes in pulmonary function are attributed to major adaptations in the maternal respiratory system and are influenced by the mechanical pressure of enlarging gravid uterus, elevating the diaphragm and restricting the movements of lungs thus hampering the forceful expiration and also might be due to decline in alveolar Pco 2 caused by hyperventilation which acts as bronchoconstrictor; in addition to sensitization of respiratory center due to progesterone

  20. Search for Standard Model Higgs boson using the H → ZZ → 2l2ν channel in pp collisions at CMS

    Directory of Open Access Journals (Sweden)

    Ranjan Kirti

    2012-06-01

    Full Text Available A search for the Standard Model (SM Higgs boson in pp collisions at the LHC at a center-of-mass energy of 7 TeV is presented. The results are based on a data sample corresponding to an integrated luminosity of 1.6 fb−1 recorded by the CMS experiment. The search is conducted in the decay channel H → ZZ → 2l2ν. No excess is observed in the transverse mass distributions. Limits are set on the production of the Higgs boson in the context of the Standard Model and in the presence of a sequential fourth family of fermions with high masses.

  1. Analysis of blood stem cell activity and cystatin gene expression in a mouse model presenting a chromosomal deletion encompassing Csta and Stfa2l1.

    Science.gov (United States)

    Bilodeau, Mélanie; MacRae, Tara; Gaboury, Louis; Laverdure, Jean-Philippe; Hardy, Marie-Pierre; Mayotte, Nadine; Paradis, Véronique; Harton, Sébastien; Perreault, Claude; Sauvageau, Guy

    2009-10-19

    The cystatin protein superfamily is characterized by the presence of conserved sequences that display cysteine protease inhibitory activity (e.g., towards cathepsins). Type 1 and 2 cystatins are encoded by 25 genes of which 23 are grouped in 2 clusters localized on mouse chromosomes 16 and 2. The expression and essential roles of most of these genes in mouse development and hematopoiesis remain poorly characterized. In this study, we describe a set of quantitative real-time PCR assays and a global expression profile of cystatin genes in normal mouse tissues. Benefiting from our collection of DelES embryonic stem cell clones harboring large chromosomal deletions (to be reported elsewhere), we selected a clone in which a 95-kb region of chromosome 16 is missing (Del(16qB3Delta/+)). In this particular clone, 2 cystatin genes, namely Csta and Stfa2l1 are absent along with 2 other genes (Fam162a, Ccdc58) and associated intergenic regions. From this line, we established a new homozygous mutant mouse model (Del(16qB3Delta/16qB3Delta)) to assess the in vivo biological functions of the 2 deleted cystatins. Stfa2l1 gene expression is high in wild-type fetal liver, bone marrow, and spleen, while Csta is ubiquitously expressed. Homozygous Del(16qB3Delta/16qB3Delta) animals are phenotypically normal, fertile, and not overtly susceptible to spontaneous or irradiation-induced tumor formation. The hematopoietic stem and progenitor cell activity in these mutant mice are also normal. Interestingly, quantitative real-time PCR expression profiling reveals a marked increase in the expression levels of Stfa2l1/Csta phylogenetically-related genes (Stfa1, Stfa2, and Stfa3) in Del(16qB3Delta/16qB3Delta) hematopoietic tissues, suggesting that these candidate genes might be contributing to compensatory mechanisms. Overall, this study presents an optimized approach to globally monitor cystatin gene expression as well as a new mouse model deficient in Stfa2l1/Csta genes, expanding the

  2. Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family

    Indian Academy of Sciences (India)

    AAMIR ALI; SHWETA TYAGI

    2017-03-01

    WD repeat containing protein 5 (WDR5), Retinoblastoma Binding Protein 5 (RbBP5), Absent-Small-Homeotic-2-Like protein (ASH2L), and Dumpy-30 (Dpy30) have been reported to be the integral and shared components of all theSET1 family of histone 3 lysine 4 histone methyltransferase (HMT) complexes. Collectively called the WRADcomplex, these proteins are pivotal to the HMT activity of the SET1 complexes. Recent reports highlight the novelnon-canonical functions of WRAD in cellular processes other than its well-studied role in histone methylation andgene expression. In this review, we examine the diversity in emerging transcription-independent functions of WRAD.

  3. First detection of methicillin-resistant Staphylococcus aureus ST398 and Staphylococcus pseudintermedius ST68 from hospitalized equines in Spain.

    Science.gov (United States)

    Gómez-Sanz, E; Simón, C; Ortega, C; Gómez, P; Lozano, C; Zarazaga, M; Torres, C

    2014-05-01

    Eight coagulase-positive staphylococci from equines with different pathologies obtained between 2005 and 2011 were investigated. Isolates were characterized by different molecular techniques (spa-, agr-, MLST), and clonal relatedness of strains was investigated by ApaI and SmaI PFGE. Anti-microbial resistance and virulence profiles were determined. Six isolates were identified as Staphylococcus aureus, and two as Staphylococcus pseudintermedius. Of these, four isolates were methicillin-resistant S. aureus (MRSA) ST398 and one S. pseudintermedius was mecA positive and typed as ST68. One MRSA ST398 strain was isolated in 2005 and might be one of the earliest MRSA ST398 descriptions in Spain. All 5 mecA-positive strains were multidrug resistant and were isolated from hospitalized equines. Three MRSA ST398 strains carried the recently described transposon Tn559 within the chromosomal radC gene. The mecA-positive S. pseudintermedius ST68 strain was also multidrug resistant and harboured the erm(B)-Tn5405-like element. This ST68 strain presented a clear susceptible phenotype to oxacillin and cefoxitin regardless of the presence of an integral and conserved mecA gene and mecA promoter, which enhances the need for testing the presence of this gene in routine analysis to avoid treatment failures. These data reflect the extended anti-microbial resistance gene acquisition capacities of both bacterial species and evidence their pathogenic properties. The first detection of MRSA ST398 and S. pseudintermedius ST68 in horses in Spain is reported.

  4. Discover the Hidden Jewels in Your Library and Sharing the Wealth through Collaboration. Selected Papers from PIALA 2011, Pacific Islands Association of Libraries, Archives, and Museums Annual Conference (21st, Kosrae, Federated States of Micronesia, November 14-17, 2011)

    Science.gov (United States)

    Drake, Paul B., Ed.

    2012-01-01

    This publication follows the tradition of publishing selected papers from Pacific Islands Association of Libraries, Archives and Museums (PIALA) annual conferences. This 21st annual conference was held in Kosrae, Federated States of Micronesia, November 14-17, 2011. The volume begins with a listing of the members of the PIALA 2011 Planning…

  5. Influence of high-dose lipid lowering treatment compared to low-dose lipid lowering treatment on plaque composition assessed by intravascular ultrasound virtual histology in patients with ST-segment elevation acute myocardial infarction

    DEFF Research Database (Denmark)

    Egede, Rasmus; Jensen, Lisette Okkels; Hansen, Henrik Steen

    2013-01-01

    -naive patients with ST-segment elevation myocardial infarction (STEMI) were randomised to 5 mg or 40 mg rosuvastatin. The volume of each plaque component (necrotic core, fibrous tissue, fibro-fatty, and dense calcium) was assessed at baseline and after 12 months of follow-up. Baseline low-density lipoprotein...

  6. Modification of the Steel Surface Treated by a Volume Discharge Plasma in Nitrogen at Atmospheric Pressure

    Science.gov (United States)

    Erofeev, M. V.; Shulepov, M. A.; Ivanov, Yu. F.; Oskomov, K. V.; Tarasenko, V. F.

    2016-03-01

    Effect of volume discharge plasma initiated by an avalanche electron beam on the composition, structure, and properties of the surface steel layer is investigated. Voltage pulses with incident wave amplitude up to 30 kV, full width at half maximum of about 4 ns, and wave front of about 2.5 ns were applied to the gap with an inhomogeneous electric field. Changes indicating the hardening effect of the volume discharge initiated by an avalanche electron beam are revealed in St3-grade steel specimens treated by the discharge of this type.

  7. Lithium Resources for the 21st Century

    Science.gov (United States)

    Kesler, S.; Gruber, P.; Medina, P.; Keolian, G.; Everson, M. P.; Wallington, T.

    2011-12-01

    Lithium is an important industrial compound and the principal component of high energy-density batteries. Because it is the lightest solid element, these batteries are widely used in consumer electronics and are expected to be the basis for battery electric vehicles (BEVs), hybrid electric vehicles (HEVs) and plug-in hybrid electric vehicles (PHEVs) for the 21st century. In view of the large incremental demand for lithium that will result from expanded use of various types of EVs, long-term estimates of lithium demand and supply are advisable. For GDP growth rates of 2 to 3% and battery recycling rates of 90 to 100%, total demand for lithium for all markets is expected to be a maximum of 19.6 million tonnes through 2100. This includes 3.2 million tonnes for industrial compounds, 3.6 million tonnes for consumer electronics, and 12.8 million tonnes for EVs. Lithium-bearing mineral deposits that might supply this demand contain an estimated resource of approximately 39 million tonnes, although many of these deposits have not been adequately evaluated. These lithium-bearing mineral deposits are of two main types, non-marine playa-brine deposits and igneous deposits. Playa-brine deposits have the greatest immediate resource potential (estimated at 66% of global resources) and include the Salar de Atacama (Chile), the source of almost half of current world lithium production, as well as Zabuye (China/Tibet) and Hombre Muerto (Argentina). Additional important playa-brine lithium resources include Rincon (Argentina), Qaidam (China), Silver Peak (USA) and Uyuni (Bolivia), which together account for about 35% of the estimated global lithium resource. Information on the size and continuity of brine-bearing aquifers in many of these deposits is limited, and differences in chemical composition of brines from deposit to deposit require different extraction processes and yield different product mixes of lithium, boron, potassium and other elements. Numerous other brines in playas

  8. Characteristics of potential repository wastes. Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    1992-07-01

    The LWR spent fuels discussed in Volume 1 of this report comprise about 99% of all domestic non-reprocessed spent fuel. In this report we discuss other types of spent fuels which, although small in relative quantity, consist of a number of diverse types, sizes, and compositions. Many of these fuels are candidates for repository disposal. Some non-LWR spent fuels are currently reprocessed or are scheduled for reprocessing in DOE facilities at the Savannah River Site, Hanford Site, and the Idaho National Engineering Laboratory. It appears likely that the reprocessing of fuels that have been reprocessed in the past will continue and that the resulting high-level wastes will become part of defense HLW. However, it is not entirely clear in some cases whether a given fuel will be reprocessed, especially in cases where pretreatment may be needed before reprocessing, or where the enrichment is not high enough to make reprocessing attractive. Some fuels may be canistered, while others may require special means of disposal. The major categories covered in this chapter include HTGR spent fuel from the Fort St. Vrain and Peach Bottom-1 reactors, research and test reactor fuels, and miscellaneous fuels, and wastes generated from the decommissioning of facilities.

  9. Posteruption glacier development within the crater of Mount St. Helens, Washington, USA

    Science.gov (United States)

    Schilling, S.P.; Carrara, P.E.; Thompson, R.A.; Iwatsubo, E.Y.

    2004-01-01

    The cataclysmic eruption of Mount St. Helens on May 18, 1980, resulted in a large, north-facing amphitheater, with a steep headwall rising 700 m above the crater floor. In this deeply shaded niche a glacier, here named the Amphitheater glacier, has formed. Tongues of ice-containing crevasses extend from the main ice mass around both the east and the west sides of the lava dome that occupies the center of the crater floor. Aerial photographs taken in September 1996 reveal a small glacier in the southwest portion of the amphitheater containing several crevasses and a bergschrund-like feature at its head. The extent of the glacier at this time is probably about 0.1 km2. By September 2001, the debris-laden glacier had grown to about 1 km2 in area, with a maximum thickness of about 200 m, and contained an estimated 120,000,000 m3 of ice and rock debris. Approximately one-third of the volume of the glacier is thought to be rock debris derived mainly from rock avalanches from the surrounding amphitheater walls. The newly formed Amphitheater glacier is not only the largest glacier on Mount St. Helens but its aerial extent exceeds that of all other remaining glaciers combined. Published by University of Washington.

  10. St. John Shallow-water Ground Validation Transects

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Benthic habitat maps of the nearshore marine environment of St. John, U.S. Virgin Islands were created by visual interpretation of remotely sensed imagery. The...

  11. Hydrogeology - MO 2014 Thermoclines StFrancois Aquifer (SHP)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — St. Francois Aquifer thermo cline correlates the temperature data throughout the state in the Lower Cambrian Series, from the Bonneterre Formation to the Lamotte...

  12. 21st Colloquium on African Geology——CAG21

    Institute of Scientific and Technical Information of China (English)

    Lopo Vasconcelos

    2006-01-01

    @@ Under the auspices of the Geological Society of Africa (GSAf), the Geological Mining Association of Mozambique (AGMM) organized the 21st Colloquium on African Geology under the theme "Geoscience for Poverty Relief.

  13. St. Lazaria Island Alaska Maritime NWR military contaminants investigations

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — St. Lazaria Island, part of the Alaska Maritime National Wildlife Refuge, has over 540,000 burrow nesting Leach's and fork-tailed storm-petrels (Oceanodroma...

  14. Wetlands Management Review of St. Vincent Island NWR

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this wetland review was to evaluate past management and provide recommendations for future management of the impounded wetlands on St. Vincent Island....

  15. St. Vincent Island : A Prospective National Wildlife Refuge in Florida

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — A proposal is under consideration which could result in the acquisition by the United States of St. Vincent Island, a 12,000-acre tract of land in Franklin County,...

  16. St. Catherine Creek NWR Hunting Season Harvest Totals

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Data summaries from hunting that occurs on St. Catherine Creek NWR. Reports include summarized harvest and hunter effort data and basic analysis of these data.

  17. Fish Kill Investigations : St. Vincent National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This memo summarizes an investigation that took place after a massive fish kill in 5 of the 6 ponds on St. Vincent National Wildlife Refuge. Two days of field...

  18. EMSL Quarterly Highlights Report: 1st Quarter, Fiscal Year 2009

    Energy Technology Data Exchange (ETDEWEB)

    Showalter, Mary Ann; Kathmann, Loel E.; Manke, Kristin L.

    2009-02-02

    The EMSL Quarterly Highlights Report covers the science, staff and user recognition, and publication activities that occurred during the 1st quarter (October 2008 - December 2008) of Fiscal Year 2009.

  19. Electronic Health Records Place 1st at Indy 500

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues EHR Electronic Health Records Place 1st at Indy 500 Past ... last May's Indy 500 had thousands of personal Electronic Health Records on hand for those attending—and ...

  20. St. Vincent National Wildlife Refuge : 1993 Rainfall Data

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document contains graphs and tables summarizing rainfall totals on St. Vincent National Wildlife Refuge between September and October of 1993.

  1. St. Vincent National Wildlife Refuge: Comprehensive Conservation Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Comprehensive Conservation Plan (CCP) was written to guide management on St. Vincent NWR for the next 15 years. This plan outlines the Refuge vision and purpose...

  2. Food Habits of St. Vincent Island Sambars and Hogs

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Sambar deer Cervus unicolor and feral hogs Sus scrofs coninhabit St. Vincent Island, Florida. Rumen samples were analyzed to assess the dietary overlap of the two...

  3. Animal Control Plan for St. Vincent National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This plan is developed as the general policy to govern future control efforts of feral hog, beaver, and raccoon populations on the St. Vincent National Wildlife...

  4. Animal Control Plan for St. Marks National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This plan is developed as the general policy to govern future control efforts of feral hog, beaver, and raccoon populations on the St. Marks National Wildlife...

  5. St. Marks National Wildlife Refuge: Comprehensive Conservation Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Comprehensive Conservation Plan (CCP) was written to guide management on St. Marks NWR for the next 15 years. This plan outlines the Refuge vision and purpose...

  6. Sediment contamination survey on St. Marks National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — A survey was conducted by the U.S. Fish and Wildlife Service to assess habitat quality on the St. Marks National Wildlife Refuge (NWR). Sediment samples were...

  7. Refuge Objectives for St. Vincent National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document contains the Refuge Objective Statement for St. Vincent National Wildlife Refuge. Refuge background, qualitative objectives, and quantitative...

  8. St. Catherine Creek NWR Bird Point Count Data

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Data collected during bird point counts at St. Catherine Creek NWR using the Lower Mississippi Valley Joint Venture protocol for forest dwelling birds.

  9. St. Catherine Creek National Wildlife Refuge: Comprehensive Conservation Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Comprehensive Conservation Plan (CCP) was written to guide management on St. Catherine Creek NWR for the next 15 years. This plan outlines the Refuge vision and...

  10. Fishery Management Plan : St. Vincent National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The aquatic habitat available for sportfishing on St. Vincent National Wildlife Refuge consists of six fresh water lakes totaling 272 acres of water. Fishery...

  11. 33 CFR 110.193a - St. Joseph Bay, Fla.

    Science.gov (United States)

    2010-07-01

    ...′30″, 3,100 yards southeast of FW South Channel Light and 5,250 yards south of FW North Channel Light... northeast of the north entrance channel to Port St. Joe, Florida. (2) Explosives Anchorage Area 2....

  12. Chemical analysis of sediments from the St. Lawrence River

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report provides the results of a preliminary study of sediment contaminant levels in the St. Lawrence River. Sediment was sampled at 1 6 different locations...

  13. Texting While Parenting: a 21st Century Trap

    Science.gov (United States)

    ... html Texting While Parenting: A 21st Century Trap Smartphones can get in the way of family life, and stress is the result, study finds To use the sharing features on this page, please enable JavaScript. (*this news ...

  14. St. Vincent National Wildlife Refuge Forest Management Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Virgin timber stood on St. Vincent Island until the early forties when sold by the estate of Dr. Pierce. Other timber cuts were made during the period I960 through...

  15. EMSL Quarterly Highlights Report: 1st Quarter, FY08

    Energy Technology Data Exchange (ETDEWEB)

    Showalter, Mary Ann

    2008-01-28

    The EMSL Quarterly Highlights Report covers the science, staff and user recognition, and publication activities that occurred during the 1st quarter (October 2007 - December 2007) of Fiscal Year 2008.

  16. Fire Management Review of St. Vincent Island NWR

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Fire Management Review for St. Vincent National Wildlife Refuge covers habitat management including: open sand ridges, marshes, pine flatwoods, scrub, and oak...

  17. St. Vincent NWR Seaside Sparrow Project, 2002 Field Season

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — During the breeding season in 2001, the seaside sparrow population was surveyed in different fire treatment areas of Mallard Slough Marsh at St. Vincent NWR. The...

  18. St. Vincent Island White-Tailed Deer Monitoring Program

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The white tailed deer herd on St. Vincent Island represents an important part of the island's biotic community. To maintain the integrity of the island's deer...

  19. Clinical Application of the Acupoint Fenglong (ST 40)

    Institute of Scientific and Technical Information of China (English)

    Chen Su; Xu Shanning; Mao Shuzhang

    2007-01-01

    @@ As a Luo (Connecting) point of the Stomach Channel, Fenglong (ST 40) has the actions of dispelling phlegm, normalizing the stomach by sending down the adverse flow of qi, and strengthening the functions of the spleen and the stomach.

  20. Correspondence Regarding the Purchase of St. Vincent Island

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document contains a series of letters discussing the sale of St. Vincent Island. Robert Bishop wishes to purchase the island and writes back and forth with the...