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Sample records for voiding dysfunction results

  1. Voiding dysfunction - A review

    Directory of Open Access Journals (Sweden)

    Sripathi V

    2005-01-01

    Full Text Available In a child who is toilet trained the sudden onset of daytime wetting with frequency or urgency is alarming to the parents. Initially this subject was subdivided into a number of descriptive clinical conditions which led to a lot of confusion in recognition and management. Subsequently, the term elimination dysfunction was coined by Stephen Koff to emphasise the association between recurrent urinary infection, wetting, constipation and bladder overactivity. From a urodynamic point of view, in voiding dysfunction, there is either detrusor overactivity during bladder filling or dyssynergic action between the detrusor and the external sphincter during voiding. Identifying a given condition as a ′filling phase dysfunction′ or ′voiding phase dysfunction′ helps to provide appropriate therapy. Objective clinical criteria should be used to define voiding dysfunction. These include bladder wall thickening, large capacity bladder and infrequent voiding, bladder trabeculation and spinning top deformity of the urethra and a clinically demonstrated Vincent′s curtsy. The recognition and treatment of constipation is central to the adequate treatment of voiding dysfunction. Transcutaneous electric nerve stimuation for the treatment of detrusor overactivity, biofeedback with uroflow EMG to correct dyssynergic voiding, and behavioral therapy all serve to correct voiding dysfunction in its early stages. In established neurogenic bladder disease the use of Botulinum Toxin A injections into the detrusor or the external sphincter may help in restoring continence especially in those refractory to drug therapy. However in those children in whom the upper tracts are threatened, augmentation of the bladder may still be needed.

  2. Neurogenic voiding dysfunction.

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    Georgopoulos, Petros; Apostolidis, Apostolos

    2017-05-01

    This review aims to analyze and discuss all recently published articles associated with neurogenic voiding discussion providing readers with the most updated knowledge and trigger for further research. They include the proposal of a novel classification system for the pathophysiology of neurogenic lower urinary tract dysfunction (NLUTD) which combines neurological defect in a distinct anatomic location, and data on bowel dysfunction, autonomic dysreflexia and urine biomarkers; review of patient-reported outcome measures in NLUTD; review of the criteria for the diagnosis of clinically significant urinary infections; novel research findings on the pathophysiology of NLUTD; and review of data on minimally and more invasive treatments. Despite the extended evidence base on NLUTD, there is a paucity of high-quality new research concerning voiding dysfunction as opposed to storage problems. The update aims to inform clinicians about new developments in clinical practice, as well as ignite discussion for further clinical and basic research in the aforementioned areas of NLUTD.

  3. Do public schools teach voiding dysfunction? Results of an elementary school teacher survey.

    Science.gov (United States)

    Cooper, Christopher S; Abousally, Chadi T; Austin, J Christopher; Boyt, Margaret A; Hawtrey, Charles E

    2003-09-01

    Dysfunctional voiding in children may partly be learned, and constitutes a significant percentage of pediatric urological referrals. Half of a child's waking hours are spent at school, suggesting a significant potential impact on learned toileting behaviors. Nonetheless, data on teacher perception and practice regarding pediatric voiding are lacking. A total of 1,000, 21-question surveys were mailed to randomly selected Iowa public elementary school teachers, of which 467 were returned and analyzed. Eighty percent of respondents reported set times for student bathroom breaks. More than half requested all children go to the bathroom at the set times. One-third asked a child requesting a break in the middle of class to wait. Thirty-five percent and 48%, respectively, reported the boys and girls bathrooms were always sanitary. Forty-seven percent and 36% believed bathroom sanitation was progressively worse during the day for boys and girls bathrooms, respectively. Forty-two percent and 34% noticed bullying and lack of supervision, respectively, in the boys bathrooms. Seventeen percent, 16% and 15% suspect an underlying health problem in children who urinate more frequently than normal, or wet or defecate in their pants, respectively. More experienced teachers are significantly more likely to report these suspicions to the school nurse. Only 18% of respondents reported receiving information about abnormal voiding or stooling. Only 8% were aware of specialists trained to treat children with these problems. Teachers report suboptimal toileting conditions for many children at public schools. These conditions appear to become significantly worse following kindergarten. Teachers have the potential to have a significant impact on dysfunctional voiding but are infrequently informed regarding these issues.

  4. Effectiveness of tolterodine in nonneurogenic voiding dysfunction.

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    Babu, Ramesh

    2006-11-01

    The efficacy of tolterodine was analysed in children with non-neurogenic voiding dysfunction, using dysfunctional voiding symptom score (DVSS). Of 44 patients (mean age 9.3 yrs; M:F = 25:19), 36 received long acting tolterodine tartrate at a dose of 2mg OD and 8 at a dose of 4mg OD. The mean (SD) DVSS before and after the treatment was 17.1 (2.8) and 12.0 (2.4). There was a significant improvement in the mean DVSS score at the end of the treatment (Students t test P tolterodine is effective in children with voiding dysfunction. The single daily dose has good compliance and minimal side effect profile.

  5. Voiding dysfunction in children aged five to 15 years

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    Karaklajić Dragana

    2004-01-01

    Full Text Available Voiding dysfunction in children was analyzed in 91 patients in a period from January 1st to October 1st 1998. Most of the patients had functional voiding disorder (92.31%, and only 7.69% manifested monosymptomatic night enuresis. The number of girls was bigger in the group of patients with voiding dysfunction while the boys were predominant in the group with mono-symptomatic nocturnal enuresis. More than a half of children with functional voiding disorder had repeated urinal infections (58.23%, incontinence (93.49%, need for urgent voiding (68.13%, and vesicoureteral reflux (47.61%. The most common type of voiding dysfunction was urge syndrome/urge incontinence. The incidence of dysfunctional voiding disorder was more often in children with scaring changes of kidney which were diagnosed by static scintigraphy.

  6. Post-void residual urine under 150 ml does not exclude voiding dysfunction in women

    DEFF Research Database (Denmark)

    Khayyami, Yasmine; Klarskov, Niels; Lose, Gunnar

    2016-01-01

    INTRODUCTION AND HYPOTHESIS: It has been claimed that post-void residual urine (PVR) below 150 ml rules out voiding dysfunction in women with stress urinary incontinence (SUI) and provides license to perform sling surgery. The cut-off of 150 ml seems arbitrary, not evidence-based, and so we sough...

  7. Breaking the vicious circle: Onabotulinum toxin A in children with therapy-refractory dysfunctional voiding

    NARCIS (Netherlands)

    L.A. 't Hoen (Lisette); J. van den Hoek (Joop); K.P. Wolffenbuttel (Katja); F. van der Toorn; J.R. Scheepe (Jeroen)

    2015-01-01

    textabstractIntroduction An increased activity of the external urethral sphincter or pelvic floor muscles during voluntary voiding leads to dysfunctional voiding. Frequently reported symptoms are urinary incontinence, urinary tract infections and high post-void residuals. Dysfunctional voiding is a

  8. Parents Function and Behavioral Disorders in Children with and without Diurnal Voiding Dysfunction: A Comparative Study

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    Parsa Yousefi

    2014-09-01

    Full Text Available Background: Diurnal voiding dysfunction is one of the most common causes of pediatric urology clinic admissions. It can cause behavioral problems for children and their parents. We lunch this study to compare the parents’ function and children’s behavior problem in pediatric patients suffering from diurnal voiding dysfunction referring Arak Amir Kabir hospital. Materials and Methods: To perform this case-control study, we recruit 116 children with diurnal voiding dysfunction and compared them with other 116 children non-affected children aged between 5 to 16 years old. The child behavior checklist (CBCL4/18 for children behavior assessment and Global Assessment of Functioning (GAF for the evaluation of their parent’s behavior was completed by the parents. Data was analyzed using ANOVA, qualitative variables and χ2 formula. Results: Among 116 patient with voiding dysfunction, 10 case (8.6% showed behavioral problem while this figure was 3 case (2.6% in the control group, denoting a significant difference (p=0.04. Moreover 20 children (17.2% in the case group and 9 children (7.8% in the control group had internalizing problem (p=0.02. Twenty two children (19% with voiding dysfunction and 8 children (6.9% in the healthy group had externalizing problem which was also a significant difference (p=0.01. As a significant difference (0.01, the parent’s average stress and behavior scores in case and control group were 3.65 and 3.76, respectively. Conclusion: The higher prevalence of behavioral problem in the children suffering from diurnal voiding dysfunction and their parent’s functional impairment highlights the importance of early parent’s intervention for early treatment and subsequently prevention of future behavioral problem in their sibling.

  9. Urodynamic analysis and treatment of male Parkinson's disease patients with voiding dysfunction

    Institute of Scientific and Technical Information of China (English)

    Xue Peng; Wang Tao; Zong Huantao; Zhang Yong

    2014-01-01

    Background Parkinson's disease (PD) is an extrapyramidal neurological disorder.Urinary symptoms are frequently present in patients affected by PD.Symptoms such as urgency,frequency,nocturia,and urge incontinence significantly impact the patient's quality of life.We attempted to investigate the urodynamic changes and treatment of male PD patients with voiding dysfunction by means of a review.Methods Comprehensive urodynamic examinations were performed in 141 male patients with PD associated with voiding dysfunction.Appropriate treatments were given to subgroups that were divided based on test results,and the changes in urodynamic parameters as well as the treatment efficacy were observed.Results Detrusor hyperreflexia without bladder outlet obstruction (BOO) was observed in 35 patients,who exhibited significant improvements in the international prostate symptom score (IPSS),maximum flow rate (Qmax),bladder volume at the first desire to void,post-void residual (PVR),and bladder compliance.Detrusor hyperreflexia associated with BOO was observed in 59 patients.The patients exhibited significant improvements in IPSS,Qmax,PVR,and bladder compliance.Detrusor dysfunction without BOO was observed in 19 patients,for whom the IPSS and the bladder volume at the first desire to void were improved after treatment.Detrusor dysfunction with BOO was found in 28 patients,with no significant improvement in the urodynamic parameters after the treatment.Conclusions Urodynamic examination is recommended for male Parkinson's disease patients with voiding dysfunction.Early and effective treatment can improve the bladder function and quality of life of these patients.

  10. Risk Factors of Voiding Dysfunction and Patient Satisfaction After Tension-free Vaginal Tape Procedure

    OpenAIRE

    2005-01-01

    This study was undertaken to identify risk factors for postoperative voiding dysfunction and factors having impact on patient global satisfaction after a tension-free vaginal tape (TVT) procedure. Two hundred and eighty-five women who underwent the TVT procedure for stress urinary incontinence were analyzed to identify risk factors predictive of voiding dysfunction. Postoperative voiding dysfunction was defined as a peak urinary flow rate (PFR) 30% of bladder capacity (incomplete emptying, n=...

  11. Voiding dysfunction in patients with nasal congestion treated with pseudoephedrine: a prospective study

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    Shao IH

    2016-07-01

    Full Text Available I-Hung Shao,1,* Chia-Chen Wu,2,* Hsiao-Jung Tseng,3 Ta-Jen Lee,2 Yu-Hsiang Lin,4 Yuan-Yun Tam5 1Division of Urology, Department of Surgery, Lotung Poh-Ai Hospital, Yilan County, 2Department of Otorhinolaryngology – Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, Chang Gung University, 3Biostatistical Center for Clinical Research, Chang-Gung Memorial Hospital, Taoyuan City, 4Division of Urology, Department of Surgery, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, 5Department of Otorhinolaryngology – Head and Neck Surgery, Lotung Poh-Ai Hospital, Yilan County, Taiwan *These authors contributed equally to this work Background: Pseudoephedrine is a sympathomimetic drug widely used as a nasal decongestant. However, it can cause adverse effects, such as voiding dysfunction. The risk of voiding dysfunction remains uncertain in patients without subjective voiding problems.Methodology: We prospectively enrolled patients with nasal congestion who required treatment with pseudoephedrine from May to August 2015. All patients denied concomitant subjective voiding problem. The International Prostate Symptom Score (IPSS questionnaire was used to evaluate voiding function before and 1 week after the pseudoephedrine treatment. The results of the IPSS questionnaire were analyzed as the total (IPSS-T, voiding (IPSS-V, storage (IPSS-S, and quality of life due to urinary symptom scores.Results: We enrolled 131 males with a mean age of 42.0±14.3 years. The IPSS-T, IPSS-V, and IPSS-S scores slightly increased after the medication (IPSS-T increased from 6.49 to 6.77, IPSS-V from 3.33 to 3.53, and IPSS-S from 3.17 to 3.24. The quality of life due to urinary symptom score nonsignificantly decreased from 2.02 to 1.87. We observed that older age and a higher premedication IPSS-V score yielded significant differences (P<0.05 for subclinical voiding dysfunction and unchanged voiding function. In patients aged ≥50 years, the IPSS

  12. Can a four-session biofeedback regimen be used effectively for treating children with dysfunctional voiding?

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    Sener, Nevzat Can; Altunkol, Adem; Unal, Umut; Ercil, Hakan; Bas, Okan; Gumus, Kemal; Ciftci, Halil; Yeni, Ercan

    2015-01-01

    To compare the outcomes of the open-ended six to ten sessions of biofeedback against a novel regime of four sessions of biofeedback to treat children with dysfunctional voiding. Patients from two centers using different methods were retrospectively analyzed. Group 1 comprised 20 patients treated with four sessions of biofeedback. Group 2 comprised 20 patients treated with six to ten sessions of biofeedback. Each group was evaluated with subjective and objective parameters pre-treatment, immediately post-treatment and 6 months post-treatment. All patients in Group 1 were treated with four sessions of biofeedback and in Group 2 the mean number of sessions was 7.35±1.30 (range 6-10). Normalized voiding flow curves after treatment were determined in 18 patients in Group 1 (90%) and 19 patients in Group 2 (95%) (p=0.553). There were seven patients (35%) in Group 1 and eight patients (40%) in Group 2 with reflux. When units were compared, there were 11 units (4 bilateral) in Group 1 and 13 units (5 bilateral) in Group 2 with reflux (p=0.747). At 6 months post-treatment, in Group 1, seven had resolved (63.6%), three had improved (27.2%) and one persisted (9.01%). In Group 2, ten had resolved (76.9%) and three had improved (23.1%) (p=0.553). Biofeedback therapy is one of the most widely used techniques in dysfunctional voiding in children. The regime of use has not been well defined, and the results of this study showed that a regime of four sessions of biofeedback therapy may be as safe and effective as the previously defined open-ended six to ten sessions.

  13. Evaluation and Targeted Therapy of Voiding Dysfunction in Children.

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    Palmer, Lane S

    2016-06-01

    Significant strides have been made over the past two decades in more precisely evaluating and managing children with voiding complaints. A thorough history should offer insight into the possible causes for the presenting complaints and this should be supplemented by physical examination, urine studies, and select imaging. Uroflowmetry and external sphincter electromyography with measurement of postvoid residual urine should allow for accurate diagnosis using categories offered by the International Children's Continence Society. This ability to make an accurate diagnosis should naturally lead to the use of treatment options (urotherapy, pharmacotherapy, biofeedback, and neuromodulation) that specifically target the responsible cause of the complaints rather than simply their symptoms.

  14. Utility of Voiding Dysfunction Symptom Score in Diagnosis and Treatment of Enuresis Nocturna

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    Yılören Tanıdır

    2017-03-01

    Full Text Available Objective: The aim of this study was to determine the effectiveness of the voiding dysfunction symptom score (VDSS in evaluation of children with nocturnal enuresis. Materials and Methods: Four hundred children with nocturnal enuresis were included in the study. They were evaluated with VDSS, physical examination, urinalysis and 2-day voiding diary. All children with nocturnal enuresis symptoms were treated with desmopressin and/or urotherapy. However, children with overactive bladder symptoms were also treated with anticholinergics. Treatment success and change in VDSS were compared and assessed between different treatment methods. Results: Two hundred forty-five children (61.25% were male and 155 (38.75% were female. The mean age was 7.6±3.0 years (range: 5-18. The mean VDSS was 9.2±6.3. 35% of children with nocturnal enuresis had concomitant daytime symptoms. 126 children (31.5% had a VDSS of nine or above and majority of these children were treated with anticholinergic therapy. VDSS questionnaire could not help determine treatment success in children with non-monosymptomatic nocturnal enuresis. However, children treated with urotherapy and desmopressine showed significant difference in VDSSs according to their treatment response. Conclusion: VDSS has shown to decrease after treatment in children with mono-symptomatic nocturnal enuresis. The treatment strategies should be checked and modified if VDSS does not decrease after proper therapy as this would increase the success of treatment.

  15. Recurring priapism may be a symptom of voiding dysfunction – case report and literature review

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    Lisieux Eyer de Jesus

    2016-04-01

    Full Text Available ABSTRACT Recurring priapism is rare in pre-pubertal children and may be attributed to multiple causes. We propose that voiding dysfunction (VD may also justify this symptom and detail a clinical case of recurring stuttering priapism associated to overactive bladder that completely resolved after usage of anticholinergics and urotherapy. Sacral parasympathetic activity is responsible for detrusor contraction and for spontaneous erections and a relationship between erections and bladder status has been proved in healthy subjects (morning erections and models of medullar trauma. High bladder pressures and/or volumes, voiding incoordination and posterior urethritis can potentially trigger reflex erections.

  16. Near-Infrared Spectroscopy of the Bladder: New Parameters for Evaluating Voiding Dysfunction

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    Andrew Macnab

    2011-01-01

    Full Text Available We describe innovative methodology for monitoring alterations in bladder oxygenation and haemodynamics in humans using near-infrared spectroscopy (NIRS. Concentrations of the chromophores oxygenated (O2Hb and deoxygenated (HHb haemoglobin and their sum (total haemoglobin differ during bladder contraction in health and disease. A wireless device that incorporates three paired light emitting diodes (wavelengths 760 and 850 nanometers and silicon photodiode detector collects data transcutaneously (10 Hz with the emitter/detector over the bladder during spontaneous bladder emptying. Data analysis indicates comparable patterns of change in chromophore concentration in healthy children and adults (positive trend during voiding, predominantly due to elevated O2Hb, but different changes in symptomatic subjects with characteristic chromophore patterns identified for voiding dysfunction due to specific pathophysiologies: bladder outlet obstruction (males, overactive bladder (females, and nonneurogenic dysfunction (children. Comparison with NIRS muscle data suggests altered bladder haemodynamics and/or oxygenation may underlie voiding dysfunction offering new insight into the causal physiology.

  17. Results and applications in thermoelasticity of materials with voids

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    Michele Ciarletta

    1991-05-01

    Full Text Available We consider the linear theory of a thermoelastic porous solid in which the skeletal or matrix is a thermoelastic material and the interstices are void of material. We assume that the initial body is free from stresses. The concept of a distributed body asserts that the mass density at time t has the decomposition γν, where γ is the density of the matrix material and ν (0 In the first part, in order to derive some applications of the reciprocity theorem, we recall some results established by same authors in [3]. Then we obtain integral representations of the solution and prove that the solving of the boundary-initial value problem can be reduced to the solving of an associated uncoupled problem and to an integral equation for the volume fraction field.

  18. Void Dynamics

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    Padilla, Nelson D.; Paz, Dante; Lares, Marcelo; Ceccarelli, Laura; Lambas, Diego Garcí A.; Cai, Yan-Chuan; Li, Baojiu

    2016-10-01

    Cosmic voids are becoming key players in testing the physics of our Universe.Here we concentrate on the abundances and the dynamics of voids as these are among the best candidatesto provide information on cosmological parameters. Cai, Padilla & Li (2014)use the abundance of voids to tell apart Hu & Sawicki f(R) models from General Relativity. An interestingresult is that even though, as expected, voids in the dark matter field are emptier in f(R) gravity due to the fifth force expellingaway from the void centres, this result is reversed when haloes are used to find voids. The abundance of voids in this casebecomes even lower in f(R) compared to GR for large voids. Still, the differences are significant and thisprovides a way to tell apart these models. The velocity field differences between f(R) and GR, on the other hand, arethe same for halo voids and for dark matter voids.Paz et al. (2013), concentrate on the velocity profiles around voids. First they show the necessityof four parameters to describe the density profiles around voids given two distinct voidpopulations, voids-in-voids and voids-in-clouds. This profile is used to predict peculiar velocities around voids,and the combination of the latter with void density profiles allows the construction of modelvoid-galaxy cross-correlation functions with redshift space distortions. When these modelsare tuned to fit the measured correlation functions for voids and galaxies in the SloanDigital Sky Survey, small voids are found to be of the void-in-cloud type, whereas largerones are consistent with being void-in-void. This is a novel result that is obtaineddirectly from redshift space data around voids. These profiles can be used toremove systematics on void-galaxy Alcock-Pacinsky tests coming from redshift-space distortions.

  19. The relevance of urodynamic studies for urge syndrome and dysfunctional voiding : A multicenter controlled trial in children

    NARCIS (Netherlands)

    Bael, An; Lax, Hildegard; de Jong, Tom P. V. M.; Hoebeke, Piet; Nijman, Rien J. M.; Sixt, Rune; Verhulst, John; Hirche, Herbert; van Gool, Jan D.

    2008-01-01

    Purpose: The objective of this study was to compare prospectively, in urge syndrome and dysfunctional voiding, clinical patterns with urodynamic patterns, to assess changes in urodynamic patterns after treatment, and to correlate urodynamic patterns and parameters with treatment outcome. Materials a

  20. Testosterone and 17β-estradiol induce glandular prostatic growth, bladder outlet obstruction, and voiding dysfunction in male mice.

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    Nicholson, Tristan M; Ricke, Emily A; Marker, Paul C; Miano, Joseph M; Mayer, Robert D; Timms, Barry G; vom Saal, Frederick S; Wood, Ronald W; Ricke, William A

    2012-11-01

    Benign prostatic hyperplasia (BPH) and bladder outlet obstruction (BOO) are common in older men and can contribute to lower urinary tract symptoms that significantly impact quality of life. Few existing models of BOO and BPH use physiological levels of hormones associated with disease progression in humans in a genetically manipulable organism. We present a model of BPH and BOO induced in mice with testosterone (T) and 17β-estradiol (E(2)). Male mice were surgically implanted with slow-releasing sc pellets containing 25 mg T and 2.5 mg E(2) (T+E(2)). After 2 and 4 months of hormone treatment, we evaluated voiding patterns and examined the gross morphology and histology of the bladder, urethra, and prostate. Mice treated with T+E(2) developed significantly larger bladders than untreated mice, consistent with BOO. Some mice treated with T+E(2) had complications in the form of bladder hypertrophy, diverticula, calculi, and eventual decompensation with hydronephrosis. Hormone treatment caused a significant decrease in the size of the urethral lumen, increased prostate mass, and increased number of prostatic ducts associated with the prostatic urethra, compared with untreated mice. Voiding dysfunction was observed in mice treated with T+E(2), who exhibited droplet voiding pattern with significantly decreased void mass, shorter void duration, and fewer sustained voids. The constellation of lower urinary tract abnormalities, including BOO, enlarged prostates, and voiding dysfunction seen in male mice treated with T+E(2) is consistent with BPH in men. This model is suitable for better understanding molecular mechanisms and for developing novel strategies to address BPH and BOO.

  1. The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction: alpha-Blockers in the Treatment of Male Voiding Dysfunction - How Do They Work and Why Do They Differ in Tolerability?

    NARCIS (Netherlands)

    Michel, M.C.

    2010-01-01

    alpha(1)-Adrenoceptor antagonists are the mainstay of medical treatment of male voiding dysfunction which typically is attributed to benign prostatic hyperplasia While original concepts have assumed that they relieve voiding dysfunction by relaxing prostatic smooth muscle, newer data indicate that t

  2. Noxious electrical stimulation of the pelvic floor and vagina induces transient voiding dysfunction in a rabbit survival model of pelvic floor dystonia

    OpenAIRE

    Dobberfuhl, Amy D.; Spettel, Sara; Schuler, Catherine; Levin, Robert M.; Dubin, Andrew H.; De, Elise J.B.

    2015-01-01

    Purpose Existing data supports a relationship between pelvic floor dysfunction and lower urinary tract symptoms. We developed a survival model of pelvic floor dysfunction in the rabbit and evaluated cystometric (CMG), electromyographic (EMG) and ambulatory voiding behavior. Materials and Methods Twelve female adult virgin rabbits were housed in metabolic cages to record voiding and defecation. Anesthetized CMG/EMG was performed before and after treatment animals (n=9) received bilateral tetan...

  3. Urodynamic features of the voiding dysfunction in HTLV-1 infected individuals

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    Neviton M. Castro

    2007-04-01

    Full Text Available OBJECTIVE:To describe urodynamic abnormalities in HTLV-1 infected individuals presenting urinary symptoms and verify if these findings and quality of life (QOL evaluation correlate with overall neurological impairment. MATERIALS AND METHODS: From January/2001 to May/2004, 324 HTLV-1 seropositive subjects were evaluated to determine the occurrence of urinary symptoms. Urodynamic testing was performed in those who complained of frequency, urgency, or incontinence. They went through a complete clinical, neurological, and urological examination to investigate symptoms and signs of myelopathy. Neurological disability was assessed by Expanded Disability Status Scale (EDSS. RESULTS: From the 324 patients evaluated, 78 underwent the urodynamic testing. Fifty-seven individuals were females (73.1% and age ranged from 23 to 76 years (mean = 48.7 years; SD ± 11.6. Urodynamic testing was abnormal in 63 patients (80.8%. The major abnormality was detrusor overactivity (DO, observed in 33 individuals (33/63; 52.4%, followed by detrusor-external sphincter dyssynergia (DESD, diagnosed in 15 subjects (15/63; 25.4%. HAM/TSP patients had significantly more DESD than the HTLV-I carriers (p = 0.005; OR = 5.5; CI: 1.6 to 19.4. QOL was severely compromised in HAM/TSP patients. CONCLUSIONS: Prominent urodynamic abnormalities were identified in individuals genuinely considered as HTLV-I carriers, suggesting an early compromise of the urinary tract; whereas HAM/TSP patients presented urodynamic findings, which posed a potential risk to the upper urinary tract (dyssynergia. Urodynamic evaluation should be performed in all HTLV-I-infected individuals with voiding complaints.

  4. Applications of neurostimulation for urinary storage and voiding dysfunction in neurological patients.

    NARCIS (Netherlands)

    Rey, FS Van; Heesakkers, J.P.F.A.

    2008-01-01

    The application of various forms of electrical stimulation is considered a therapeutic option to manage different types of lower urinary tract dysfunction. However, even though lower urinary tract dysfunction is common in patients with neurological disease, apart from patients with spinal cord injur

  5. Applications of neurostimulation for urinary storage and voiding dysfunction in neurological patients.

    NARCIS (Netherlands)

    Rey, FS Van; Heesakkers, J.P.F.A.

    2008-01-01

    The application of various forms of electrical stimulation is considered a therapeutic option to manage different types of lower urinary tract dysfunction. However, even though lower urinary tract dysfunction is common in patients with neurological disease, apart from patients with spinal cord

  6. Applications of neurostimulation for urinary storage and voiding dysfunction in neurological patients.

    NARCIS (Netherlands)

    Rey, FS Van; Heesakkers, J.P.F.A.

    2008-01-01

    The application of various forms of electrical stimulation is considered a therapeutic option to manage different types of lower urinary tract dysfunction. However, even though lower urinary tract dysfunction is common in patients with neurological disease, apart from patients with spinal cord injur

  7. Water avoidance stress results in an altered voiding phenotype in male mice.

    Science.gov (United States)

    McGonagle, Erin; Smith, Ariana; Butler, Stephan; Sliwoski, Joanna; Valentino, Rita; Canning, Douglas; Zderic, Stephen A

    2012-09-01

    We set out to characterize the voiding phenotypes of male mice to a water avoidance stress (WAS) protocol and compare the molecular changes with those induced by surgically induced partial bladder outlet obstruction (pBOO). Six-week-old male Swiss Webster mice housed with sibling littermates were individually placed on a platform centered in the middle of a water filled basin for 1 hr daily for 4 weeks. A non stressed cohort of sibling littermates served as controls. Measured end points included voiding frequency, voided volume, bladder mass, and in vivo cystometry. Molecular end points included myosin heavy chain (MHC) isoform distribution by PCR, and nuclear translocation of hypoxia inducible factor (HIF1α) and the nuclear factor of activated T-cells (NFAT) by gel shift assay. These molecular endpoints were compared with samples from male mice undergoing anatomic pBOO. WAS resulted in increased average voided volumes and bladder mass, and a decrease in voiding frequency (P < 0.05). The slower MHC A isoform was only expressed in the pBOO group that developed severe hypertrophy. Gel shift assays revealed substantial increases in HIF1-α nuclear translocation in the group subjected to pBOO that developed severe hypertrophy but minimal changes in the pBOO group that developed minimal hypertrophy and the swim stress groups. The WAS model induces moderate bladder wall hypertrophy in the absence of any surgical manipulation. Copyright © 2012 Wiley Periodicals, Inc.

  8. A Visual Basic program for analyzing oedometer test results and evaluating intergranular void ratio

    Science.gov (United States)

    Monkul, M. Murat; Önal, Okan

    2006-06-01

    A visual basic program (POCI) is proposed and explained in order to analyze oedometer test results. Oedometer test results have vital importance from geotechnical point of view, since settlement requirements usually control the design of foundations. The software POCI is developed in order perform the necessary calculations for convential oedometer test. The change of global void ratio and stress-strain characteristics can be observed both numerically and graphically. It enables the users to calculate some parameters such as coefficient of consolidation, compression index, recompression index, and preconsolidation pressure depending on the type and stress history of the soil. Moreover, it adopts the concept of intergranular void ratio which may be important especially in the compression behavior of sandy soils. POCI shows the variation of intergranular void ratio and also enables the users to calculate granular compression index.

  9. Factor analysis of the pediatric symptom checklist in a population of children with voiding dysfunction and/or nocturnal enuresis.

    Science.gov (United States)

    Wolfe-Christensen, Cortney; Fedele, David A; Grant, DeMond; Veenstra, Amy L; Kovacevic, Larisa G; Elder, Jack S; Lakshmanan, Yegappan

    2014-03-01

    The research objective was to identify the factor structure of the pediatric symptom checklist (PSC) in children with voiding dysfunction and/or nocturnal enuresis who were seen in a pediatric urology clinic. Retrospective chart reviews were conducted for 498 consecutive patients, ages 6-16, who were seen over a 13-month period. The PSC, a 35-item measure used to screen for psychosocial difficulties, was completed by the patient's caregiver. Confirmatory factor analyses using three previous models were conducted. A four factor model comprised of internalizing, externalizing, attention problems, and chronic illness factors represented the best fit to the data. Within this population, the PSC appears to capture internalizing and externalizing problems, difficulties with attention, and possible side effects of a medical condition. This information could aid clinicians in assessing adjustment difficulties within this population and concurrently allow researchers to examine whether these specific factors are related to other relevant outcomes.

  10. The NACHT, LRR and PYD Domains-Containing Protein 3 (NLRP3) Inflammasome Mediates Inflammation and Voiding Dysfunction in a Lipopolysaccharide-Induced Rat Model of Cystitis.

    Science.gov (United States)

    Hughes, Francis M; Kennis, James G; Youssef, Melissa N; Lowe, Danielle W; Shaner, Brooke E; Purves, J Todd

    2016-02-01

    NOD-like receptors (NLRs) sense sterile and non-sterile signals and form inflammasomes which trigger an inflammatory response through the activation of caspase-1 and release of IL-1β. Recently we have shown the presence of several NLRs in the bladder urothelia and demonstrated the importance of NLRP3 in bladder outlet obstruction and cyclophosphamide-induced cystitis, both models of sterile inflammation. In this study we explore a role for NLRP3 in mediating the response to LPS, a key antigen of uropathogenic bacteria. In order to bypass the protective glycosaminoglycan layer lining the urothelium, LPS was directly injected into the bladder wall of Sprague-Dawley rats. Glyburide (a NLRP3 inhibitor) or vehicle was administered orally prior to and after injection. Rats were analyzed 24 h later. Inflammasome activity (caspase-1 activity, IL-1β release) and inflammation (Evan's Blue extravasation, bladder weight) were assessed, as was physiological bladder function (urodynamics). Injection of LPS stimulated inflammasome activation (caspase-1 activity) and the release of IL-1β into the urine which was prevented by glyburide. Likewise, LPS increased inflammation, (bladder weight and the extravasation of Evan's blue dye), and this was reversed by glyburide. Functionally, animals injected with saline alone demonstrated decreased voiding volume as measured by urodynamics. In the presence of LPS, additional urinary dysfunction was evident with decreased voiding pressures and threshold pressures. The decrease in voiding pressure was blocked by glyburide but the decrease in threshold pressure was not, suggesting that LPS has significant effects mediated by inflammasome-dependent and -independent mechanisms. Overall, the results demonstrate the potential importance of inflammasomes in bacterial cystitis as well as the ability of the bladder wall injection technique to isolate the in vivo effects of specific inflammasome ligands to the physiological changes associated with

  11. Computerized voiding diary.

    Science.gov (United States)

    Rabin, J M; McNett, J; Badlani, G H

    1993-01-01

    An electronic, computerized voiding diary, "Compu-Void" (patent pending) was developed in order to simplify, augment, and automate patients' recording of bladder symptomatology. A voiding diary as a tool has the potential to provide essential information for a more complete diagnostic and therefore therapeutic picture for each patient. Two major problems with the standard written voiding diary have been a lack of patient compliance and the limited amount of information it garners. Twenty-five women with various types of voiding dysfunctions were compared to twenty-five age and parity-matched control women in order to determine patient preferences of the Compu-Void when compared to the standard written voiding diary, compliance with each method, and amount and quality of information obtained with each method. Over 90% of subjects and over 70% of control group patients preferred the Compu-Void over the written diary (P Compu-Void exceeded that obtained with the written method.

  12. 3D modeling of void nucleation and initial void growth due to Tin diffusion as a result of electromigration in polycrystalline lead-free solders

    Science.gov (United States)

    Karunakaran, Deepak

    Electromigration (EM) has been a serious reliability concern in microelectronics packaging for close to half a century now. Whenever the challenges of EM are overcome newer complications arise such as the demand for better performance due to increased miniaturization of semiconductor devices or the problems faced due to undesirable properties of lead-free solders. The motivation for the work is that there exists no fully computational modeling study on EM damage in lead-free solders (and also in lead-based solders). Modeling techniques such as one developed here can give new insights on effects of different grain features and offer high flexibility in varying parameters and study the corresponding effects. In this work, a new computational approach has been developed to study void nucleation and initial void growth in solders due to metal atom diffusion. It involves the creation of a 3D stochastic mesoscale model of the microstructure of a polycrystalline Tin structure. The next step was to identify regions of current crowding or 'hot-spots'. This was done through solving a finite difference scheme on top of the 3D structure. The nucleation of voids due to atomic diffusion from the regions of current crowding was modeled by diffusion from the identified hot-spot through a rejection free kinetic Monte-Carlo scheme. This resulted in the net movement of atoms from the cathode to the anode. The above steps of identifying the hotspot and diffusing the atoms at the hotspot were repeated and this lead to the initial growth of the void. This procedure was studied varying different grain parameters. In the future, the goal is to explore the effect of more grain parameters and consider other mechanisms of failure such as the formation of intermetallic compounds due to interstitial diffusion and dissolution of underbump metallurgy.

  13. Comparison of tolterodine with standard treatment in pediatric patients with non-neurogenic dysfunctional voiding/over active bladder: a systematic review.

    Science.gov (United States)

    Medhi, B; Mittal, N; Bansal, D; Prakash, A; Sarangi, S C; Nirthi, B

    2013-01-01

    To examine the efficacy, safety and tolerability of tolterodine in children with overactive bladder in comparison with standard treatment i.e. oxybutynin as demonstrated in randomized clinical trials and other studies. A systematic search was done to screen the studies evaluating the effect of tolterodine in children with non-neurogenic overactive bladder. Results of studies were pooled and compared. Efficacy was determined from micturition diaries and dysfunctional voiding symptoms score. Safety and tolerability were assessed from the reported treatment emergent adverse events. A total of six randomized clinical trials and 11 other studies of tolterodine in children with urinary incontinence were included in the present systematic review. The dose of tolterodine used in different settings ranged from '0.5 to 8 mg/day' instead of '0.5 to 8 mg/kg per day' and the duration of studies ranged from 2 weeks to 12 months. Both extended and immediate release preparations of tolterodine were shown to have comparable efficacy and tolterodine proved to have comparable efficacy with better tolerability than oxybutynin in these studies. It can be concluded that tolterodine is efficacious in treatment of urinary incontinence in children. Moreover, its efficacy is comparable to oxybutynin, the most commonly prescribed anticholinergic in this condition, while having better tolerability. Hence, it can be considered as first line therapy for the treatmentof urinary incontinence in children.

  14. Perineal surface electromyography does not typically demonstrate expected relaxation during normal voiding.

    Science.gov (United States)

    Kirby, Anna C; Nager, Charles W; Litman, Heather J; Fitzgerald, Mary P; Kraus, Stephen; Norton, Peggy; Sirls, Larry; Rickey, Leslie; Wilson, Tracey; Dandreo, Kimberly J; Shepherd, Jonathan; Zimmern, Philippe

    2011-11-01

    To describe perineal surface patch electromyography (EMG) activity during urodynamics (UDS) and compare activity between filling and voiding phases and to assess for a relationship between preoperative EMG activity and postoperative voiding symptoms. 655 women underwent standardized preoperative UDS that included perineal surface EMG prior to undergoing surgery for stress urinary incontinence. Pressure-flow studies were evaluated for abdominal straining and interrupted flow. Quantitative EMG values were extracted from 10 predetermined time-points and compared between fill and void. Qualitative EMG activity was assessed for the percent of time EMG was active during fill and void and for the average amplitude of EMG during fill compared to void. Postoperative voiding dysfunction was defined as surgical revision or catheterization more than 6 weeks after surgery. Fisher's exact test with a 5% two-sided significance level was used to assess differences in EMG activity and postoperative voiding dysfunction. 321 UDS had interpretable EMG studies, of which 131 (41%) had EMG values at all 10 predetermined and annotated time-points. Quantitative and qualitative EMG signals during flow were usually greater than during fill. The prevalence of postoperative voiding dysfunction in subjects with higher preoperative EMG activity during void was not significantly different. Results were similar in the 42 subjects who had neither abdominal straining during void nor interrupted flow. Perineal surface patch EMG did not measure expected pelvic floor and urethral sphincter relaxation during voiding. Preoperative EMG did not predict patients at risk for postoperative voiding dysfunction. Copyright © 2011 Wiley Periodicals, Inc.

  15. The Void Galaxy Survey

    CERN Document Server

    van de Weygaert, R; Platen, E; Beygu, B; van Gorkom, J H; van der Hulst, J M; Aragon-Calvo, M A; Peebles, P J E; Jarrett, T; Rhee, G; Kovac, K; Yip, C -W

    2011-01-01

    The Void Galaxy Survey (VGS) is a multi-wavelength program to study $\\sim$60 void galaxies. Each has been selected from the deepest interior regions of identified voids in the SDSS redshift survey on the basis of a unique geometric technique, with no a prior selection of intrinsic properties of the void galaxies. The project intends to study in detail the gas content, star formation history and stellar content, as well as kinematics and dynamics of void galaxies and their companions in a broad sample of void environments. It involves the HI imaging of the gas distribution in each of the VGS galaxies. Amongst its most tantalizing findings is the possible evidence for cold gas accretion in some of the most interesting objects, amongst which are a polar ring galaxy and a filamentary configuration of void galaxies. Here we shortly describe the scope of the VGS and the results of the full analysis of the pilot sample of 15 void galaxies.

  16. On recoil energy dependent void swelling in pure copper: part 1, experimental results

    DEFF Research Database (Denmark)

    Singh, B.N.; Eldrup, M.; Horsewell, Andy

    2000-01-01

    , the void swelling should sensitively depend on the recoil energy since it affects strongly the intracascade clustering of SIAs and vacancies, particularly at lower recoil energies. In order to test the validity of this prediction directly by experiments, pure and annealed copper specimens were irradiated...... with 2.5 MeV electrons, 3 MeV protons and fission neutrons at about 520K. All three sets of irradiation experiments were carried out with a similar damage rate (of the order of 10-8 NRT dpa/s). Post-irradiation defect microstructures were investigated using electrical resistivity, transmission electron...... microscopy (TEM) and positron annihilation spectroscopy (PAS). The accumulation of defects in the form of planar clusters as well as voids is found to increase substantially with increasing recoil energy. This is in good accord with the predictions of the PBM....

  17. Patients with a history of infection and voiding dysfunction are at risk for recurrence after successful endoscopic treatment of vesico ureteral reflux and deserve long-term follow up

    Directory of Open Access Journals (Sweden)

    R Coletta

    2012-01-01

    Conclusions: Preoperative recurrent IVU, together with high-grade reflux, seem to correlate to lower success rate of Deflux injection for primary VUR. Even after successful endoscopic treatment, long-term surveillance may be needed among these cases, mainly if voiding dysfunction is also recorded. Late recurring VUR must be actively excluded in case of new IVU episodes.

  18. Results of sacral neuromodulation therapy for urinary voiding dysfunction: outcomes of a prospective, worldwide clinical study.

    NARCIS (Netherlands)

    Kerrebroeck, P.E.V.A. van; Voskuilen, A.C. van; Heesakkers, J.P.; Lycklama à Nijeholt, A.A.B.; Siegel, S.; Jonas, U.; Fowler, C.J.; Fall, M.; Gajewski, J.B.; Hassouna, M.M.; Cappellano, F.; Elhilali, M.M.; Milam, D.F.; Das, A.K.; Dijkema, H.E.; Hombergh, U. van den

    2007-01-01

    PURPOSE: This 5-year, prospective, multicenter trial evaluated the long-term safety and efficacy of sacral neuromodulation in patients with refractory urge incontinence, urgency frequency and retention. MATERIALS AND METHODS: A total of 17 centers worldwide enrolled 163 patients (87% female). Follow

  19. Transient void, pressure drop and critical power BFBT benchmark analysis and results with VIPRE-W / MEFISTO-T

    Energy Technology Data Exchange (ETDEWEB)

    Le Corre, J.M.; Adamsson, C.; Alvarez, P., E-mail: lecorrjm@westinghouse.com, E-mail: carl.adamsson@psi.ch, E-mail: alvarep@westinghouse.com [Westinghouse Electric Sweden AB (Sweden)

    2011-07-01

    A benchmark analysis of the transient BFBT data [1], measured in an 8x8 fuel assembly design under typical BWR transient conditions, was performed using the VIPRE-W/MEFISTO-T code package. This is a continuation of the BFBT steady-state benchmark activities documented in [2] and [3]. All available transient void and pressure drop experimental data were considered and the measurements were compared with the predictions of the VIPRE-W sub-channel analysis code using various modeling approaches, including the EPRI drift flux void correlation. Detailed analyses of the code results were performed and it was demonstrated that the VIPRE-W transient predictions are generally reliable over the tested conditions. Available transient dryout data were also considered and the measurements were compared with the predictions of the VIPRE-W/ MEFISTO-T film flow calculations. The code calculates the transient multi-film flowrate distributions in the BFBT bundle, including the effect of spacer grids on drop deposition enhancement, and the dryout criterion corresponds to the total liquid film disappearance. After calibration of the grid enhancement effect with a very small subset of the steady-state critical power database, the code could predict the time and location of transient dryout with very good accuracy. (author)

  20. Three-Dimensional Sonography in the Exploration of Voiding Dysfunction in Retroverted Impacted Adenomyosis: A Case Report

    Directory of Open Access Journals (Sweden)

    Pu-Tsui Wang

    2005-03-01

    Conclusion: Sonography is helpful in exploring the anatomic nature of bladder outflow obstruction resulting from retroverted impacted adenomyosis. In this case, the urethra was neither distorted nor compressed, quite different from cases with pelvic organ prolapse. These two types of bladder outflow obstruction are not distinguishable using traditional urodynamic study. Three-dimensional sonography is more helpful in identification of the compressed reshaped lower urinary bladder and its adjacent anatomic structures, even without urine in the low bladder cavity as contrast.

  1. [Cross-cultural validated adaptation of dysfunctional voiding symptom score (DVSS) to Japanese language and cognitive linguistics in questionnaire for pediatric patients].

    Science.gov (United States)

    Imamura, Masaaki; Usui, Tomoko; Johnin, Kazuyoshi; Yoshimura, Koji; Farhat, Walid; Kanematsu, Akihiro; Ogawa, Osamu

    2014-07-01

    Validated questionnaire for evaluation of pediatric lower urinary tract symptoms (LUTS) is of a great need. We performed cross-cultural validated adaptation of Dysfunctional Voiding Symptom Score (DVSS) to Japanese language, and assessed whether children understand and respond to questionnaire correctly, using cognitive linguistic approach. We translated DVSS into two Japanese versions according to a standard validation methodology: translation, synthesis, back-translation, expert review, and pre-testing. One version was written in adult language for parents, and the other was written in child language for children. Pre-testing was done with 5 to 15-year-old patients visiting us, having normal intelligence. A specialist in cognitive linguistics observed the response by children and parents to DVSS as an interviewer. When a child could not understand a question without adding or paraphrasing the question by the parents, it was defined as 'misidentification'. We performed pretesting with 2 trial versions of DVSS before having the final version. The pre-testing for the first trial version was done for 32 patients (male to female ratio was 19 : 13). The pre-testing for the second trial version was done for 11 patients (male to female ratio was 8 : 3). In DVSS in child language, misidentification was consistently observed for representation of time or frequency. We completed the formal validated translation by amending the problems raised in the pre-testing. The cross-cultural validated adaptation of DVSS to child and adult Japanese was completed. Since temporal perception is not fully developed in children, caution should be taken for using the terms related with time or frequency in the questionnaires for children.

  2. Responsibility voids

    NARCIS (Netherlands)

    van Hees, M.V.B.P.M; Braham, Matthew

    We present evidence for the existence of 'responsibility voids' in committee decision-making, that is, the existence of situations where no member of a committee can individually be held morally responsible for the outcome. We analyse three types of reasons (causal, normative and epistemic) for the

  3. Evaluation of sacral neuromodulation in treating 34 cases of chronic voiding-defecation dysfunction%骶神经调节测试治疗慢性功能性尿便障

    Institute of Scientific and Technical Information of China (English)

    卫中庆; Ernest Weil; 易超然; 宋涛; 于洪波; 文伟; 孙则禹; Philip Van Kerrebroeck

    2009-01-01

    Objective To explore the effectiveness and security of temporary lead and tined lead in evaluation of sacral neuromodulation. Methods Thirty four cases with chronic voiding-defecation dysfunction, in which 4 cases were refractory urgent incontinence. 8 cases were refractory urinary urgency-frequency, 8 cases(6 cases with constipation) were chronic un-obstructive urinary retention, 4 cases were chronic pelvic pain syndrome or IC, 10 cases neurogenic bladder (3 and 7 cases resulted from spinal cord injury and Spina bifida respectively) . Temporary test electrodes and tined-lead were implanted into 16 and 18 cases respectively. And then the temporary stimulation tests were performed in a period of 5 ~ 14 days, recorded the daily times and volume of voiding and the related urodynamic parameters. And comparing the effectiveness of the two groups was performed. Results In patients with urgent incontinence and urinary urgency-frequency syndrome their improvements were 43 % and 35 % respectively. About 10% were cured completely. In chronic voiding-defecation dysfunction, there were 32.3 % and 38.2 % improvement respectively in temporary and tined lead group with significant difference. There were 23.7 % and 28.3 % improvement of IC respectively in temporary lead and tined lead group in the respects of volume voiding and pain amelioration. In temporary lead and tined lead group shifting of electrode position occurred in 4 cases and 1 case respectively. Conclusion Sacral neuromodulation is a secure, minimally invasive, effective method for chronic voiding dysfunction; tined lead electrode has the superiorities of minimally invasive, prevents the shift position of the electrode, and raised the effective rate.%目的 探讨骶神经调节测试评估阶段临时电极及自固定倒齿状电极(Tined Lead)的疗效及安全性.方法 34例慢性尿便功能障碍患者,其中难治性急迫性尿失禁4例,难治性尿频、尿急综合症8例,非梗阻性慢性尿潴留8

  4. Lipasuria in acute pancreatitis: result of tubular dysfunction?

    Science.gov (United States)

    Muench, R; Buehler, H; Kehl, O; Ammann, R

    1987-01-01

    Lipase, in contrast to amylase, is completely reabsorbed by the proximal tubules after glomerular filtration. Therefore, no lipase is detectable in the unconcentrated urine according to the current opinion. The handling of lipase (detected with an enzyme-immunoassay) by the kidney was investigated in comparison with creatinine, amylase, and beta-2-microglobulin by clearance studies in acute pancreatitis (n = 10), burn injury (n = 4), glomerular proteinuria (n = 8), and controls without evidence of pancreatic or renal diseases (n = 5). In initial stages of acute pancreatitis a measurable clearance of lipase (mean: 49.6 microliters/min, range: 0.5-234) was found in association with corresponding increased clearances of beta-2-microglobulin (mean: 10.5 ml/min, range: 0.02-58.9) and of amylase (mean: 8.9 ml/min, range: 2.4-22.6) in nine of ten patients. This finding is consistent with a defect of tubular function. However, regression analysis failed to show a significant correlation between lipase and beta-2-microglobulin clearance. Repeated measurements during the course of pancreatitis in seven patients showed reversibility of tubular dysfunction. In patients with burn injury a similar elevation of clearances of beta-2-microglobulin and of amylase was found, but tubular dysfunction in this condition was not associated with lipasuria. In glomerular proteinuria a lipase clearance was found in two of five cases with moderate, and in the other three cases with severe impairment of creatinine clearance. beta-2-microglobulin clearance was normal in the former and only slightly elevated in the latter group. In conclusion lipase is measurable in the urine of most patients with acute pancreatitis as a result of a reversible tubular dysfunction.(ABSTRACT TRUNCATED AT 250 WORDS)

  5. Evaluation of School Children%u2019s Voiding Problems in Sakarya Region

    Directory of Open Access Journals (Sweden)

    Adil Sonbahar

    2014-03-01

    Full Text Available Aim: Our goal was to determine the types of voiding problems of children%u2019s between 6 and 15 years old in Sakarya region. Material and Method: Totally 3246, 5-16 years old student randomly selected from 8 schools inside province. Students are evaluated in an appropriate room at school with a form pre-prepared in our clinic. Results: The survey shows that 486 of 3246 students (15% have voiding problems. The prevalance of dysfunctional voiding problems in all children, was 11.2%(365, nocturia prevalence was 8.7% (279, diurnal enuresis was 1% (32. In boys (totally 1573 the prevalance of dysfunctional voiding problems was 9% (145, nocturia prevalence was 11.7%(184, enuresis nocturia prevalence 11.2% (176, diurnal enuresis was 0.5% (8. In girls (totally 1673 the prevalance of dysfunctional voiding problems was 13.4 (223, nocturia prevalence was 6.7% (111, enuresis nocturia prevalence was 6.2% (103, diurnal enuresis prevalance was 1.4% (24. There was no meaningful statistical difference from the perspective of height and body mass index (BMI between the children with voiding problems and without any problem (p>0.05 . Discussion: The results for enuresis nocturna, nocturia and diurnal enuresis we have got from our study, are similar to ones that have been done in our country before. There is no data for prevalence od dysfunctional voiding study so far. Dysfunctional voiding problems in girls and in children who are in first years of school are more frequent.

  6. International Prostatic Symptom Score-voiding/storage subscore ratio in association with total prostatic volume and maximum flow rate is diagnostic of bladder outlet-related lower urinary tract dysfunction in men with lower urinary tract symptoms.

    Directory of Open Access Journals (Sweden)

    Yuan-Hong Jiang

    Full Text Available OBJECTIVES: The aim of this study was to investigate the predictive values of the total International Prostate Symptom Score (IPSS-T and voiding to storage subscore ratio (IPSS-V/S in association with total prostate volume (TPV and maximum urinary flow rate (Qmax in the diagnosis of bladder outlet-related lower urinary tract dysfunction (LUTD in men with lower urinary tract symptoms (LUTS. METHODS: A total of 298 men with LUTS were enrolled. Video-urodynamic studies were used to determine the causes of LUTS. Differences in IPSS-T, IPSS-V/S ratio, TPV and Qmax between patients with bladder outlet-related LUTD and bladder-related LUTD were analyzed. The positive and negative predictive values (PPV and NPV for bladder outlet-related LUTD were calculated using these parameters. RESULTS: Of the 298 men, bladder outlet-related LUTD was diagnosed in 167 (56%. We found that IPSS-V/S ratio was significantly higher among those patients with bladder outlet-related LUTD than patients with bladder-related LUTD (2.28±2.25 vs. 0.90±0.88, p1 or >2 was factored into the equation instead of IPSS-T, PPV were 91.4% and 97.3%, respectively, and NPV were 54.8% and 49.8%, respectively. CONCLUSIONS: Combination of IPSS-T with TPV and Qmax increases the PPV of bladder outlet-related LUTD. Furthermore, including IPSS-V/S>1 or >2 into the equation results in a higher PPV than IPSS-T. IPSS-V/S>1 is a stronger predictor of bladder outlet-related LUTD than IPSS-T.

  7. Variables predictive of voiding disfunction following aponeurotic sling surgery: multivariate analysis

    Directory of Open Access Journals (Sweden)

    Sílvio H.M. de Almeida

    2004-08-01

    Full Text Available INTRODUCTION: Aponeurotic sling surgeries can evolve with obstruction or voiding dysfunction in 5 to 20% of patients. There are few studies on factors that could possibly predispose to voiding difficulties or urinary retention. The objective of this work is to identify these potential clinical or urodynamic factors. MATERIALS AND METHODS: Records from 130 patients who underwent aponeurotic sling surgeries were reviewed. All patients underwent a throughout urodynamic study during pre-operative investigation. The variables studied were age above 65 years, previous pelvic surgeries, concomitant surgeries, post-voiding residue higher than 100 mL, vesical obstruction (according to Blaivas-Groutz nomogram and urinary flow under 12 mL/s. Post-voiding residue was assessed on the seventh post-operative day through vesical catheterization. Recovering of spontaneous voiding after 7 post-operative days or with a residue higher than 100 mL, was regarded as voiding dysfunction. Univariate analysis was performed with qui-square test and Fisher's exact test, and multivariate analysis was performed by logistic regression with alpha = 5%. RESULTS: Age in the studied group ranged from 41 to 83 years (mean 56.7 years, with 69 (53% patients having urethral hypermobility and 61 (47% having intrinsic urethral lesion. Normal voiding occurred in 97 (75.6 % women with 7 post-operative days. The only significant variable in the univariate (p = 0.014 and multivariate (p = 0.017 analysis was post-voiding residue higher than 100 mL. CONCLUSION: Pre-operative presence of a post-voiding residual urine higher than 100 mL was the only variable predictive of voiding dysfunction.

  8. Thyroid dysfunction during pregnancy and evaluation of its results

    Directory of Open Access Journals (Sweden)

    Fatih Taşkesen

    2011-06-01

    Full Text Available In this study, we aim to evaluate obstetric outcomes of the women with thyroid dysfunction than the normal pregnant women.Materials and methos: In our study, 633 women between the ages of 18 to 35 who admitted to Kovancılar State Hospital Obstetrics and Gynecology Clinic for pregnancy follow-up between January 2010 and January 2011 were evaluated. Serum thyroid - stimulating hormones (TSH, free tri-iyodotironin (T3, free thyroxine (T4 levels for all patients were studied. Antithyroidal peroxidase (anti-TPO and Anti-thyroglobulin (anti-Tg parameters were measured if they were necessary. The relationship between thyroid functions and complications such as eclampsia, preeclampsia, maternal anemia, postpartum hemorrhage, fetal anomalies, shoulder dystocia, neonatal hypoglycemia was examined.Results: Hypothyroidism was found 18 of cases and hyperthyroidism was found 4 of them. The mean age of patients in the study was 26.42 (± 8.42. The mean values were 1.86 ± 0.19 μIU/mL for TSH, 1.15 ± 0.29 ng/mL for free T4 and 2.90 ± 0.31 pg/mL for free T3 respectively. Hashimoto’s thyroiditis (9 cases, 50 % was the most frequent etiology for patients with hypothyroidism. Other etiologic factors for hypothyroidism were found to be for 4 cases as (22.2%, iatrogenic (previously undergone thyroidectomy and 5 cases as (37.8% a lack of iodine. Maternal anemia was observed in 5 (27.78% cases with hypothyroidism. Preeclampsia was observed 16.67% in patients with hypothyroidism.Conclusion: Observed thyroid dysfunction in pregnant women may cause serious maternal and fetal complications. For disorders of thyroid function during pregnancy, to provide the necessary treatment at the appropriate time is important to prevent complications of mother and fetus. J Clin Exp Invest 2011;2(2:196-201

  9. Bladder Dysfunction and Vesicoureteral Reflux

    Directory of Open Access Journals (Sweden)

    Ulla Sillén

    2008-01-01

    Full Text Available In this overview the influence of functional bladder disturbances and of its treatment on the resolution of vesicoureteral reflux (VUR in children is discussed. Historically both bladder dysfunction entities, the overactive bladder (OAB and the dysfunctional voiding (DV, have been described in conjunction with VUR. Treatment of the dysfunction was also considered to influence spontaneous resolution in a positive way. During the last decades, however, papers have been published which could not support these results. Regarding the OAB, a prospective study with treatment of the bladder overactivity with anticholinergics, did not influence spontaneous resolution rate in children with a dysfunction including also the voiding phase, DV and DES (dysfunctional elimination syndrome, most studies indicate a negative influence on the resolution rate of VUR in children, both before and after the age for bladder control, both with and without treatment. However, a couple of uncontrolled studies indicate that there is a high short-term resolution rate after treatment with flow biofeedback. It should be emphasized that the voiding phase dysfunctions (DV and DES are more severe than the genuine filling phase dysfunction (OAB, with an increased frequency of UTI and renal damage in the former groups. To be able to answer the question if treatment of bladder dysfunction influence the resolution rate of VUR in children, randomized controlled studies must be performed.

  10. Investigação de disfunção miccional em uma amostra populacional de crianças de 3 a 9 anos Investigation of voiding dysfunction in a population-based sample of children aged 3 to 9 years

    Directory of Open Access Journals (Sweden)

    Denise M. Mota

    2005-06-01

    investigated using the dysfunction score created by Farhat et al. and modified by the addition of high urinary frequency (more than eight times a day. Boys with scores above eight and girls above five were clinically investigated, as well as a sub-sample of the remaining children. RESULTS: Nocturia (60.4%, urinary urgency (49.7% and holding maneuvers (42.1% were the most frequently reported symptoms. The prevalence of enuresis was 20.1% in boys and 15.1% in girls. The prevalence of urinary dysfunction was 22.8%. Most symptoms were more frequently reported by girls and younger children. Among girls, low socioeconomic level was related to an increased prevalence of enuresis and straining to urinate, while among boys urgency was more common among the poor. Only 10.5% of the parents of the children with voiding dysfunction consulted a doctor because of their problems. CONCLUSIONS: The voiding symptoms studied presented high prevalence rates, and therefore should be investigated in clinical practice, with direct questions about each symptom, aiming to diagnose voiding dysfunction.

  11. An Investigation into the Nature of Non-Voiding Contractions Resulting from Detrusor Hyperreflexia in Neurogenic Bladders Following Spinal Cord Injury

    Science.gov (United States)

    2015-06-01

    Award Number: W81XWH-12-1-0445 TITLE: An Investigation into the Nature of Non-Voiding Contractions Resulting from Detrusor Hyperreflexia in...Neurogenic Bladders Following Spinal Cord Injury PRINCIPAL INVESTIGATOR: Matthew O. Fraser, Ph.D. CONTRACTING ORGANIZATION: Institute for Medical... Contractions Resulting from Detrusor Hyperreflexia in Neurogenic Bladders Following Spinal Cord Injury 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-12-1-0445

  12. CT measurements of SAP voids in concrete

    DEFF Research Database (Denmark)

    Laustsen, Sara; Bentz, Dale P.; Hasholt, Marianne Tange

    2010-01-01

    X-ray computed tomography (CT) scanning is used to determine the SAP void distribution in hardened concrete. Three different approaches are used to analyse a binary data set created from CT measurement. One approach classifies a cluster of connected, empty voxels (volumetric pixel of a 3D image......) as one void, whereas the other two approaches are able to classify a cluster of connected, empty voxels as a number of individual voids. Superabsorbent polymers (SAP) have been used to incorporate air into concrete. An advantage of using SAP is that it enables control of the amount and size...... of the created air voids. The results indicate the presence of void clusters. To identify the individual voids, special computational approaches are needed. The addition of SAP results in a dominant peak in two of the three air void distributions. Based on the position (void diameter) of the peak, it is possible...

  13. CT measurements of SAP voids in concrete

    DEFF Research Database (Denmark)

    Laustsen, Sara; Bentz, Dale P.; Hasholt, Marianne Tange;

    2010-01-01

    X-ray computed tomography (CT) scanning is used to determine the SAP void distribution in hardened concrete. Three different approaches are used to analyse a binary data set created from CT measurement. One approach classifies a cluster of connected, empty voxels (volumetric pixel of a 3D image......) as one void, whereas the other two approaches are able to classify a cluster of connected, empty voxels as a number of individual voids. Superabsorbent polymers (SAP) have been used to incorporate air into concrete. An advantage of using SAP is that it enables control of the amount and size...... of the created air voids. The results indicate the presence of void clusters. To identify the individual voids, special computational approaches are needed. The addition of SAP results in a dominant peak in two of the three air void distributions. Based on the position (void diameter) of the peak, it is possible...

  14. Nursing of Metallic Mesh Stent Implantation in Treating Postoperative Voiding Dysfunction after Transurethral Resection of Prostate%网状支架植入术治疗前列腺电切术后排尿障碍患者的护理

    Institute of Scientific and Technical Information of China (English)

    倪娟; 岑爱萍; 邱镇; 严静萍

    2013-01-01

    目的 介绍网状支架植入术治疗前列腺电切(transurethral resection of the prostate,TURP)术后排尿障碍患者的护理方法.方法 回顾性分析2004-2011年在解放军第81医院治疗的36例良性前列腺增生患者的临床资料.所有患者均为行经尿道前列腺等离子电切术后并发排尿障碍患者,且均在局部麻醉下经超声引导置入镍钛记忆合金支架.结果 36例患者中有35例患者手术成功,支架置入5d后拔除导尿管,其中33例患者可自主排尿,尿流率恢复正常或接近正常,有效率为91.6%.1例患者因尿道狭窄未能植入支架而行膀胱造瘘,2例患者因不能耐受并发生血尿于术后第2天取出支架.结论 网状支架治疗前列腺电切术后并发排尿障碍患者的效果确切,术前宣教、术中很好配合、术后进行针对性的护理,可提高术后患者的疗效.%Objective To introduce the clinical nursing methods of metallic mesh stent implantation in treating postoperative voiding dysfunction after transurethral resection of prostate (TURP). Methods From 2004 to 2011, the clinical data of 36 patients with benign prostatic hyperplasia in the hospital were analyzed retrospectively. Nickel-titanium alloy stents were inserted under ultrasound-guidance and local anesthesia for patients with postoperative voiding dysfunction after TURP. Results In'the 36 patients,surgeries were succeeded in 35 and the stents were removed 5 d after surgery. After surgery,33 patients were able to void spontaneously with few post-void residual volume of urine and the flow rates were normal or near normal. The total effective rate was 91. 6%. Only one patient failed to implant the stents and conducted line cystostomy due to urethral stricture,and two patients removed the stents 2 d after stent implantation due to severe urinary tract symptoms and hematuria. Conclusion Metallic mesh alloy stent implantation for the treatment of voiding dysfunction after TURP has a sound

  15. PRECISION COSMOGRAPHY WITH STACKED VOIDS

    Energy Technology Data Exchange (ETDEWEB)

    Lavaux, Guilhem [Department of Physics, University of Illinois at Urbana-Champaign, 1002 West Green Street, Urbana, IL 61801 (United States); Wandelt, Benjamin D. [UPMC Univ Paris 06, UMR 7095, Institut d' Astrophysique de Paris, 98 bis, boulevard Arago, 75014 Paris (France)

    2012-08-01

    We present a purely geometrical method for probing the expansion history of the universe from the observation of the shape of stacked voids in spectroscopic redshift surveys. Our method is an Alcock-Paczynski (AP) test based on the average sphericity of voids posited on the local isotropy of the universe. It works by comparing the temporal extent of cosmic voids along the line of sight with their angular, spatial extent. We describe the algorithm that we use to detect and stack voids in redshift shells on the light cone and test it on mock light cones produced from N-body simulations. We establish a robust statistical model for estimating the average stretching of voids in redshift space and quantify the contamination by peculiar velocities. Finally, assuming that the void statistics that we derive from N-body simulations is preserved when considering galaxy surveys, we assess the capability of this approach to constrain dark energy parameters. We report this assessment in terms of the figure of merit (FoM) of the dark energy task force and in particular of the proposed Euclid mission which is particularly suited for this technique since it is a spectroscopic survey. The FoM due to stacked voids from the Euclid wide survey may double that of all other dark energy probes derived from Euclid data alone (combined with Planck priors). In particular, voids seem to outperform baryon acoustic oscillations by an order of magnitude. This result is consistent with simple estimates based on mode counting. The AP test based on stacked voids may be a significant addition to the portfolio of major dark energy probes and its potentialities must be studied in detail.

  16. A computerized voiding diary.

    Science.gov (United States)

    Rabin, J M; McNett, J; Badlani, G H

    1996-11-01

    To examine a group of subject and control patient's preferences and compliance with regard to the Compu-Void (CV) electronic voiding diary as compared to the written diary (WD) and to compare the two methods with respect to the type of information obtained and whether the order of use of each method influenced results in the subject group. Thirty-six women between the ages of 20 and 84 with bladder symptoms were compared to a group of 36 age-matched women. In 100% of subjects and 95% of control patients, CV entries exceeded the number made with the WD in voiding events and, in subjects, in incontinence episodes recorded (P < .005 and P < .005, respectively). Over 98% of subjects and over 80% of controls preferred the CV (P < .0005). The order of use of each method in subjects made no significant difference with regard to the volume of information obtained (P < .407), number of leakage events recorded (P < .494) or fluid intake patterns (P < .410). Patients' compliance with each method was not affected by the order of use. Our results suggest an increased volume of data and greater patient compliance in reporting bladder symptoms and events using the CV and that the order of use is not important.

  17. The Development of Voiding

    DEFF Research Database (Denmark)

    Olsen, Lars Henning

    2011-01-01

    The thesis addresses some new aspeccts in the development of voiding function from midgestation into early childhood.......The thesis addresses some new aspeccts in the development of voiding function from midgestation into early childhood....

  18. Supplemental topics on voids

    Energy Technology Data Exchange (ETDEWEB)

    Rood, H.J.

    1988-09-01

    Several topics concerning voids are presented, supplementing the report of Rood (1988). The discovery of the Coma supercluster and void and the recognition of the cosmological significance of superclusters and voids are reviewed. Galaxy redshift surveys and redshift surveys for the Abell clusters and very distant objects are discussed. Solar system and extragalactic dynamics are examined. Also, topics for future observational research on voids are recommended. 50 references.

  19. Size-Effects in Void Growth

    DEFF Research Database (Denmark)

    Niordson, Christian Frithiof

    2005-01-01

    The size-effect on ductile void growth in metals is investigated. The analysis is based on unit cell models both of arrays of cylindrical voids under plane strain deformation, as well as arrays of spherical voids using an axisymmetric model. A recent finite strain generalization of two higher order...... strain gradient plasticity models is implemented in a finite element program, which is used to study void growth numerically. The results based on the two models are compared. It is shown how gradient effects suppress void growth on the micron scale when compared to predictions based on conventional...... models. This increased resistance to void growth, due to gradient hardening, is accompanied by an increase in the overall strength for the material. Furthermore, for increasing initial void volume fraction, it is shown that the effect of gradients becomes more important to the overall response but less...

  20. The star formation activity in cosmic voids

    CERN Document Server

    Ricciardelli, Elena; Varela, Jesus; Quilis, Vicent

    2014-01-01

    Using a sample of cosmic voids identified in the Sloan Digital Sky Survey Data Release 7, we study the star formation activity of void galaxies. The properties of galaxies living in voids are compared with those of galaxies living in the void shells and with a control sample, representing the general galaxy population. Void galaxies appear to form stars more efficiently than shell galaxies and the control sample. This result can not be interpreted as a consequence of the bias towards low masses in underdense regions, as void galaxy subsamples with the same mass distribution as the control sample also show statistically different specific star formation rates. This highlights the fact that galaxy evolution in voids is slower with respect to the evolution of the general population. Nevertheless, when only the star forming galaxies are considered, we find that the star formation rate is insensitive to the environment, as the main sequence is remarkably constant in the three samples under consideration. This fact...

  1. Large-scale clustering of cosmic voids

    Science.gov (United States)

    Chan, Kwan Chuen; Hamaus, Nico; Desjacques, Vincent

    2014-11-01

    We study the clustering of voids using N -body simulations and simple theoretical models. The excursion-set formalism describes fairly well the abundance of voids identified with the watershed algorithm, although the void formation threshold required is quite different from the spherical collapse value. The void cross bias bc is measured and its large-scale value is found to be consistent with the peak background split results. A simple fitting formula for bc is found. We model the void auto-power spectrum taking into account the void biasing and exclusion effect. A good fit to the simulation data is obtained for voids with radii ≳30 Mpc h-1 , especially when the void biasing model is extended to 1-loop order. However, the best-fit bias parameters do not agree well with the peak-background results. Being able to fit the void auto-power spectrum is particularly important not only because it is the direct observable in galaxy surveys, but also our method enables us to treat the bias parameters as nuisance parameters, which are sensitive to the techniques used to identify voids.

  2. Nocturia: The circadian voiding disorder

    Directory of Open Access Journals (Sweden)

    Jin Wook Kim

    2016-05-01

    Full Text Available Nocturia is a prevalent condition of waking to void during the night. The concept of nocturia has evolved from being a symptomatic aspect of disease associated with the prostate or bladder to a form of lower urinary tract disorder. However, recent advances in circadian biology and sleep science suggest that it might be important to consider nocturia as a form of circadian dysfunction. In the current review, nocturia is reexamined with an introduction to sleep disorders and recent findings in circadian biology in an attempt to highlight the importance of rediscovering nocturia as a problem of chronobiology.

  3. Multiple void interaction of pipeline steel in triaxial stress fields

    Institute of Scientific and Technical Information of China (English)

    Bao-wen QIU; Ze-xi YUAN; Gui-feng ZHOU

    2008-01-01

    Three-dimensional unit cell models were developed to study the damage induced by void growth in ductile materials. Special emphasis is given to the influence of the void shape and random spatial void arrangements. The periodical void arrays of body cen-tered cubic are investigated by analyzing representative unit cells. The isotropic behavior of the matrix material is modeled using v. Mises plasticity. The cell models are analyzed by the large strain finite element method under monotonic loading while keeping the constant stress triaxiality. Results showed that when void density increased, effects of void aspects on void growth gradu-ally diminished.

  4. Effect of void cluster on ductile failure evolution

    DEFF Research Database (Denmark)

    Tvergaard, Viggo

    2016-01-01

    The behavior of a non-uniform void distribution in a ductile material is investigated by using a cell model analysis to study a material with a periodic pattern of void clusters. The special clusters considered consist of a number of uniformly spaced voids located along a plane perpendicular...... to the maximum principal tensile stress. A plane strain approximation is used, where the voids are parallel cylindrical holes. Clusters with different numbers of voids are compared with the growth of a single void, such that the total initial volume of the voids, and thus also the void volume fractions...... understanding, different transverse stresses on the unit cell are considered to see the influence of different levels of stress triaxiality. Also considered are different initial ratios of the void spacing to the void radius inside the clusters. And results are shown for different levels of strain hardening...

  5. Air void structure and frost resistance

    DEFF Research Database (Denmark)

    Hasholt, Marianne Tange

    2014-01-01

    is proportional to the product of total air content and specific surface. In all 4 cases, the conclusion is concurrent that the parameter of total surface area of air voids performs equally well or better than the spacing factor when linking air void characteristics to frost resistance (salt frost scaling...... will take place in the air void, being feed from the capillary, but without pressure build-up in the capillary. If the capillary is not connected to an air void, ice formation will take place in the capillary pore, where it can generate substantial pressure. Like this, frost resistance depends......This article compiles results from 4 independent laboratory studies. In each study, the same type of concrete is tested at least 10 times, the air void structure being the only variable. For each concrete mix both air void analysis of the hardened concrete and a salt frost scaling test...

  6. Waist circumference is superior to weight and BMI in predicting sexual symptoms, voiding symptoms and psychosomatic symptoms in men with hypogonadism and erectile dysfunction.

    Science.gov (United States)

    Yassin, A A; Nettleship, J E; Salman, M; Almehmadi, Y

    2017-05-01

    Waist circumference is considered a useful predictor of obesity-associated cardiovascular risk, but its use as an indicator of sexual health status and quality of life (QoL) in hypogonadal men is unknown. We investigated whether three measurements of obesity, weight, body mass index and waist circumference, correlate with the International Index of Erectile Function-5 (IIEF-5), the Aging Males' Symptoms (AMS) and the International Prostate Symptom Score (IPSS) questionnaires. A total of 261 patients were enrolled in a prospective study on hypogonadism treatment with intramuscular long-acting testosterone undecanoate. Patients with total testosterone ≤3.5 ng ml(-1) were enrolled, and baseline demographic data were recorded. Patient's response to IIEF, IPSS and AMS standardised questionnaires was recorded to evaluate health-related QoL. The mean length of treatment and follow-up was 4.7 years (max 6 years). ANOVA regression analysis showed that waist circumference was significantly inversely proportional to IIEF-5 and directly proportional to AMS and IPSS. Weight was inversely proportional to IIEF and directly proportional to IPSS but not associated with AMS. BMI had no proportionality to measurements of sexual function and quality of life. These results suggest that among weight, BMI and waist circumference, the latter is the best predictor of health-related QoL in men with hypogonadism.

  7. Modeling cosmic void statistics

    Science.gov (United States)

    Hamaus, Nico; Sutter, P. M.; Wandelt, Benjamin D.

    2016-10-01

    Understanding the internal structure and spatial distribution of cosmic voids is crucial when considering them as probes of cosmology. We present recent advances in modeling void density- and velocity-profiles in real space, as well as void two-point statistics in redshift space, by examining voids identified via the watershed transform in state-of-the-art ΛCDM n-body simulations and mock galaxy catalogs. The simple and universal characteristics that emerge from these statistics indicate the self-similarity of large-scale structure and suggest cosmic voids to be among the most pristine objects to consider for future studies on the nature of dark energy, dark matter and modified gravity.

  8. The sparkling Universe: a scenario for cosmic void motions

    Science.gov (United States)

    Ceccarelli, Laura; Ruiz, Andrés N.; Lares, Marcelo; Paz, Dante J.; Maldonado, Victoria E.; Luparello, Heliana E.; Garcia Lambas, Diego

    2016-10-01

    Cosmic voids are prominent features of the Universe, encoding relevant information of the growth and evolution of structure through their dynamics. Here, we perform a statistical study of the global motion of cosmic voids using both a numerical simulation and observational data. Their relation to large-scale mass flows and the physical effects that drive those motions. We analyse the bulk motions of voids, finding void mean bulk velocities in the range 300-400 km s-1, depending on void size and the large-scale environment. Statistically, small voids move faster, and voids in relatively higher density environments have higher bulk velocities. Also, we find large-scale overdensities (underdensities) along (opposite to) the void motion direction, suggesting that void motions respond to a pull-push mechanism. Our analysis suggests that their relative motions are generated by large-scale density fluctuations. In agreement with linear theory, voids embedded in low (high) density regions mutually recede (attract) each other, providing the general mechanism to understand the bimodal behaviour of void motions. We have also inferred void motions in the Sloan Digital Sky Survey using linear theory, finding that their estimated motions are in qualitatively agreement with the results of the simulation. Our results suggest a scenario of galaxies and galaxy systems flowing away from void centres with the additional, and more relevant, contribution of the void bulk motion to the total velocity.

  9. Draining the Local Void

    CERN Document Server

    Rizzi, Luca; Shaya, Edward J; Kourkchi, Ehsan; Karachentsev, Igor D

    2016-01-01

    Two galaxies that lie deep within the Local Void provide a test of the expectation that voids expand. The modest (M_B~-14) HI bearing dwarf galaxies ALFAZOAJ1952+1428 and KK246 have been imaged with Hubble Space Telescope in order to study the stellar populations and determine distances from the luminosities of stars at the tip of the red giant branch. The mixed age systems have respective distances of 8.39 Mpc and 6.95 Mpc and inferred line-of-sight peculiar velocities of -114 km/s and -66 km/s toward us and away from the void center. These motions compound on the Milky Way motion of ~230 km/s away from the void. The orbits of the two galaxies are reasonably constrained by a numerical action model encompassing an extensive region that embraces the Local Void. It is unambiguously confirmed that these two void galaxies are moving away from the void center at several hundred km/s.

  10. Dark matter in voids

    Science.gov (United States)

    Fong, Richard; Doroshkevich, Andrei G.; Turchaninov, Victor I.

    1995-07-01

    The theory of the formation of large-scale structure in the universe through the action of gravitational instability imply the existence of substantial amounts of baryonic dark matter, of the order of 50% of the total baryon content in the universe, in the ``voids'' or under-dense regions seen in the large-scale distribution of galaxies. We discuss also the large-scale structure of dark matter expected in voids and the present and future possibilities for the observation of this baryonic dark matter in ``voids.''

  11. Dark matter in voids

    Energy Technology Data Exchange (ETDEWEB)

    Fong, R. [Department of Physics, University of Durham, Durham, DH1 3LE (United Kingdom); Doroshkevich, A.G. [Keldysh Institute of Applied Mathematics, 125047 Moscow (Russian Federation)]|[Teoretical Astrophysics Centrum, Blegsdamsvej 17, Copenhagen DK 2100 (Denmark); Turchaninov, V.I. [Keldysh Institute of Applied Mathematics, 125047 Moscow (Russian Federation)

    1995-07-01

    The theory of the formation of large-scale structure in the universe through the action of gravitational instability imply the existence of substantial amounts of baryonic dark matter, of the order of 50% of the total baryon content in the universe, in the ``voids`` or under-dense regions seen in the large-scale distribution of galaxies. We discuss also the large-scale structure of dark matter expected in voids and the present and future possibilities for the observation of this baryonic dark matter in ``voids.`` {copyright} {ital 1995} {ital American} {ital Institute} {ital of} {ital Physics}.

  12. "Compu-Void II": the computerized voiding diary.

    Science.gov (United States)

    Rabin, J M; McNett, J; Badlani, G H

    1996-02-01

    We have previously described an electronic voiding diary, "Compu-Void" (Copyright, 1990) developed to automate recording of bladder symptoms (Rabin et al., 1993). Our objectives in this, the second phase of this study, were to examine a group of subject and control patients' preference and compliance with regard to the "Compu-Void" (CV) compared to the standard written voiding diary (WD), to compare the two methods with respect to the amount and type of information obtained and to determine whether or not the order of use of each recording method influenced results in the subject group. Thirty-six women between the ages of 20 and 84 with bladder symptomatology were compared to a group 36 age-matched women. In 100% of subjects and 95% of control patients, CV entries exceeded the number made with the WD in voiding events and in subjects, in incontinent episodes recorded (P < 0.0005 and P < 0.005, respectively). Over 98% of subjects and over 80% of control patients preferred CV over the WD (p < 0.0005). The order of use of each recording method in subjects made no significant difference with regard to the volume of information obtained (p < 0.407), number of urinary leakage events recorded (p < 0.494), and fluid intake patterns (p < 0.410). Patient impressions of, and compliance with each method were not affected by order of use. The only difference regarding order of use was that most subjects who used the CV first also found the WD to be tedious (61% vs 14%). Our results suggest increased volume of data and of patient compliance in reporting bladder symptoms and events using CV, and that order of use is not an important factor in determining patient impressions of the two methods. The majority of subject and control patients preferred CV over traditional methods. An updated version of the software and hardware is also included.

  13. The darkness that shaped the void: dark energy and cosmic voids

    CERN Document Server

    Bos, E G Patrick; Dolag, Klaus; Pettorino, Valeria

    2012-01-01

    Aims: We assess the sensitivity of void shapes to the nature of dark energy that was pointed out in recent studies. We investigate whether or not void shapes are useable as an observational probe in galaxy redshift surveys. We focus on the evolution of the mean void ellipticity and its underlying physical cause. Methods: We analyse the morphological properties of voids in five sets of cosmological N-body simulations, each with a different nature of dark energy. Comparing voids in the dark matter distribution to those in the halo population, we address the question of whether galaxy redshift surveys yield sufficiently accurate void morphologies. Voids are identified using the parameter free Watershed Void Finder. The effect of redshift distortions is investigated as well. Results: We confirm the statistically significant sensitivity of voids in the dark matter distribution. We identify the level of clustering as measured by \\sigma_8(z) as the main cause of differences in mean void shape . We find that in the h...

  14. Exercise-induced splanchnic hypoperfusion results in gut dysfunction in healthy men

    NARCIS (Netherlands)

    Wijck, K. van; Lenaerts, K.; Loon, L.J. van; Peters, W.H.M.; Buurman, W.A.; Dejong, C.H.

    2011-01-01

    BACKGROUND: Splanchnic hypoperfusion is common in various pathophysiological conditions and often considered to lead to gut dysfunction. While it is known that physiological situations such as physical exercise also result in splanchnic hypoperfusion, the consequences of flow redistribution at the e

  15. Extrapyramidal Motor Dysfunction and Resultant Orofacial Dystonia Post-Cocaine Abuse: A Clinical Case Study

    Science.gov (United States)

    McMicken, Betty L.; Ostergren, Jennifer A.; Vento-Wilson, Margaret

    2010-01-01

    This case study investigated the consequences of cocaine use and resultant extrapyramidal motor dysfunction. The study focused on a female client, post-long-term drug abuse with concomitant untreated head trauma, experiencing extraneous motor movements of the lips, tongue, jaw, and upper and lower extremities. The goals of this study were to (a)…

  16. Extrapyramidal Motor Dysfunction and Resultant Orofacial Dystonia Post-Cocaine Abuse: A Clinical Case Study

    Science.gov (United States)

    McMicken, Betty L.; Ostergren, Jennifer A.; Vento-Wilson, Margaret

    2010-01-01

    This case study investigated the consequences of cocaine use and resultant extrapyramidal motor dysfunction. The study focused on a female client, post-long-term drug abuse with concomitant untreated head trauma, experiencing extraneous motor movements of the lips, tongue, jaw, and upper and lower extremities. The goals of this study were to (a)…

  17. Evaluation of the effectiveness of cough test during tension-free vaginal tape procedure in preventing post-operative voiding dysfunction%咳嗽试验在经阴道无张力尿道吊带术中的应用价值

    Institute of Scientific and Technical Information of China (English)

    朱鑫; 苟欣; 何卫阳; 肖明朝; 王明; 邓远忠; 康简

    2012-01-01

    目的 探讨咳嗽试验在经阴道无张力尿道吊带术(TVT)中的应用价值. 方法 2004年1月至2010年1月确诊为女性压力性尿失禁( SsUI)的患者85例行前瞻性研究,随机分为试验组(41例)与对照组(44例).两组均行TVT手术,试验组根据咳嗽试验调整吊带张力,对照组将吊带无张力地置于尿道中段下方.比较两组患者术后48 h拔除尿管后排尿情况及术后12个月的疗效. 结果 咳嗽试验组出现排尿困难9例,其中尿潴留4例;对照组术后无排尿困难者.术后12个月随访,咳嗽试验组治愈率为92.6%( 38/41),对照组为93.1% (41/44),组间比较差异无统计学意义(P>0.05). 结论 TVT是治疗女性SUI安全有效的微创术式,但尚无证据支持咳嗽试验有助于降低TVT术后排尿困难发生风险及改善长期疗效.%Objective To evaluate the value of cough test in the tension-free vaginal tape (TVT)procedure.Methods A cohort of 85 women with stress urinary incontinence underwent the TVT procedure with cough test (n =41) or without cough test (n =44).Patients in cough test group were performed according to the Ulmsten’s method strictly,with the stress of tape adjusted in light of cough test; whereas in other 44 operations,the tape was placed on the urethral tract without stress,and no cough test was performed.The urine catheter was removed after 48 hours postoperatively and follow-up evaluation was carried out at 12 month postoperatively.Results TVT procedure was carried out successfully in all patients by a single experienced surgeon.Four cases of urinary retention and 5 cases of voiding difficulty were observed in the cough test group.However,urinary retention or voiding difficulty was not detected in the nun-cough test group.Based on the twelve-month follow-up results,the cure rate was 92.6% (38/41) in the cough test group and 93.1% (41/44) in the non-cough test group.Flow-pressure study indicated that 11 cases in cough test group were in

  18. The Hierarchical Structure and Dynamics of Voids

    CERN Document Server

    Aragon-Calvo, M A

    2012-01-01

    Contrary to the common view voids have very complex internal structure and dynamics. Here we show how the hierarchy of structures in the density field inside voids is reflected by a similar hierarchy of structures in the velocity field. Voids defined by dense filaments and clusters can de described as simple expanding domains with coherent flows everywhere except at their boundaries. At scales smaller that the void radius the velocity field breaks into expanding sub-domains corresponding to sub- voids. These sub-domains break into even smaller sub-sub domains at smaller scales resulting in a nesting hierarchy of locally expanding domains. The ratio between the magnitude of the velocity field responsible for the expansion of the void and the velocity field defining the sub voids is approximately one order of magnitude. The small-scale components of the velocity field play a minor role in the shaping of the voids but they define the local dynamics directly affecting the processes of galaxy formation and evoluti...

  19. Cluster-Void Degeneracy Breaking: Dark Energy, Planck and the Largest Cluster & Void

    CERN Document Server

    Sahlén, Martin; Silk, Joseph

    2015-01-01

    Combining galaxy cluster and void abundances breaks the degeneracy between mean matter density $\\Omega_{\\rm m}$ and power spectrum normalization $\\sigma_8$. In a first for voids, we constrain $\\Omega_{\\rm m} = 0.21 \\pm 0.10$ and $\\sigma_8 = 0.95 \\pm 0.21$ for a flat $\\Lambda$CDM universe, using extreme-value statistics on the claimed largest cluster and void. The Planck-consistent results detect dark energy with two objects, independently of other dark energy probes. Cluster-void studies also offer complementarity in scale, density, and non-linearity - of particular interest for testing modified-gravity models.

  20. A Cosmic Watershed: the WVF Void Detection Technique

    CERN Document Server

    Platen, Erwin; Jones, Bernard J T

    2007-01-01

    On megaparsec scales the Universe is permeated by an intricate filigree of clusters, filaments, sheets and voids, the Cosmic Web. For the understanding of its dynamical and hierarchical history it is crucial to identify objectively its complex morphological components. One of the most characteristic aspects is that of the dominant underdense Voids, the product of a hierarchical process driven by the collapse of minor voids in addition to the merging of large ones. In this study we present an objective void finder technique which involves a minimum of assumptions about the scale, structure and shape of voids. Our void finding method, the Watershed Void Finder (WVF), is based upon the Watershed Transform, a well-known technique for the segmentation of images. Importantly, the technique has the potential to trace the existing manifestations of a void hierarchy. The basic watershed transform is augmented by a variety of correction procedures to remove spurious structure resulting from sampling noise. This study c...

  1. Void Statistics and Void Galaxies in the 2dFGRS

    CERN Document Server

    von Benda-Beckmann, Alexander M

    2007-01-01

    For the 2dFGRS we study the properties of voids and of fainter galaxies within voids that are defined by brighter galaxies. Our results are compared with simulated galaxy catalogues from the Millenium simulation coupled with a semianalytical galaxy formation recipe. We derive the void size distribution and discuss its dependence on the faint magnitude limit of the galaxies defining the voids. While voids among faint galaxies are typically smaller than those among bright galaxies, the ratio of the void sizes to the mean galaxy separation reaches larger values. This is well reproduced in the mock galaxy samples studied. We provide analytic fitting functions for the void size distribution. Furthermore, we study the galaxy population inside voids defined by objects with $B_J -5\\log{h}< -20$ and diameter larger than 10 \\hMpc. We find a clear bimodality of the void galaxies similar to the average comparison sample. We confirm the enhanced abundance of galaxies in the blue cloud and a depression of the number of ...

  2. Modelling Void Abundance in Modified Gravity

    CERN Document Server

    Voivodic, Rodrigo; Llinares, Claudio; Mota, David F

    2016-01-01

    We use a spherical model and an extended excursion set formalism with drifting diffusive barriers to predict the abundance of cosmic voids in the context of general relativity as well as f(R) and symmetron models of modified gravity. We detect spherical voids from a suite of N-body simulations of these gravity theories and compare the measured void abundance to theory predictions. We find that our model correctly describes the abundance of both dark matter and galaxy voids, providing a better fit than previous proposals in the literature based on static barriers. We use the simulation abundance results to fit for the abundance model free parameters as a function of modified gravity parameters, and show that counts of dark matter voids can provide interesting constraints on modified gravity. For galaxy voids, more closely related to optical observations, we find that constraining modified gravity from void abundance alone may be significantly more challenging. In the context of current and upcoming galaxy surv...

  3. Sodium voiding analysis in Kalimer

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Won-Pyo; Jeong, Kwan-Seong; Hahn, Dohee [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    2001-07-01

    A sodium boiling model has been developed for calculations of the void reactivity feedback as well as the fuel and cladding temperatures in the KALIMER core after onset of sodium boiling. The sodium boiling in liquid metal reactors using sodium as coolant should be modeled because of phenomenon difference observed from that in light water reactor systems. The developed model is a multiple -bubble slug ejection model. It allows a finite number of bubbles in a channel at any time. Voiding is assumed to result from formation of bubbles that fill the whole cross section of the coolant channel except for liquid film left on the cladding surface. The vapor pressure, currently, is assumed to be uniform within a bubble. The present study is focused on not only demonstration of the sodium voiding behavior predicted by the developed model, but also confirmation on qualitative acceptance for the model. In results, the model catches important phenomena for sodium boiling, while further effort should be made for the complete analysis. (author)

  4. Underground void filling by cemented mill tailings

    Institute of Scientific and Technical Information of China (English)

    Choudhary Bhanwar Singh; Kumar Santosh

    2013-01-01

    Underground mining always create voids. These voids can cause subsidence of surface. So it is always a demand to fill the void in such a manner that the effect of underground mining can be minimized. Void filling using mill tailings especially in metal mining is one of the best techniques. The tailings produced in milling process have traditionally been disposed in tailing ponds creating a waste disposal and environ-mental problems in terms of land degradation, air and water pollution, etc. This disposal practice is more acute in the metal milling industry where the fine grinding, required for value liberation, results in the production of very fine tailings in large percentage. This paper includes discussions on the effectiveness of different paste mixes with varying cement contents in paste backfilling operations. The results revealed that material composition and use of super plasticizer strongly influenced the strength of cemented backfill.

  5. The Mechanism of Hydrogen-facilitating Initiation of Voids

    Institute of Scientific and Technical Information of China (English)

    褚武扬; 蒋兴钢; 肖纪美

    1994-01-01

    By combining the hydrogen-induced local plastic deformation theory with the decohesive theory and the hydrogen pressure theory, a new mechanism of hydrogen-facilitating initiation of voids has been proposed. Through facilitating the local plastic deformation and reducing the cohesive strength, hydrogen promotes both initiating a nanocrack and blunting the nanocrack into a void, resulting in hydrogen-promoting initiation of the void. On the other hand, hydrogen can enhance the stability of the void through reducing the cohesive strength and forming a hydrogen pressure in the void.

  6. Void shape effects and voids starting from cracked inclusion

    DEFF Research Database (Denmark)

    Tvergaard, Viggo

    2011-01-01

    Numerical, axisymmetric cell model analyses are used to study the growth of voids in ductile metals, until the mechanism of coalescence with neighbouring voids sets in. A special feature of the present analyses is that extremely small values of the initial void volume fraction are considered, dow...

  7. Bladder nerve-muscle electrical stimulation of the efficacy of observation and care of acute myelitis of voiding dysfunction%膀胱神经-肌肉电刺激对急性脊髓炎排尿障碍的疗效观察和护理

    Institute of Scientific and Technical Information of China (English)

    韦凤如

    2012-01-01

    Objective To observe the acute myelitis voiding dysfunction in patients with early use of the bladder nerves -the clinical efficacy of electrical stimulation. Methods 60 cases of acute transverse myelitis patienis were randomly divided into treatment group and control group, strengthen the care of bladder training on the basis of the early treatment group received intravesical nerve-muscle electrical stimulation in treatment of urinary function to compare two groups of patients within one month recover}' situation. Results Urinary function recover}' time of treatment group was shorter than the control group (P < 0.01). Conclusion Early bladder nerve-muscle electrical stimulation therapy can effectively promote acute transverse myelitis in patients with urinary function recovery, improve the quality of life of patients.%目的 观察急性脊髓炎排尿障碍患者早期运用膀胱神经-肌肉电刺激的临床疗效.方法 将60例急性脊髓炎患者随机分成治疗组和对照组,每组各30例.在加强排尿训练护理的基础上,治疗组患者早期给予膀胱神经-肌肉电刺激治疗,比较两组患者1个月内排尿功能恢复情况.结果 治疗组患者排尿功能恢复时间较对照组显著缩短(P<0.01).结论 早期应用膀胱神经-肌肉电刺激疗法可有效促进急性脊髓炎患者排尿功能恢复,提高患者的生活质量.

  8. Properties of Galaxies in and around Voids

    CERN Document Server

    Hopp, U

    1997-01-01

    Two surveys for intrinsically faint galaxies towards nearby voids have been conducted at the MPI für Astronomie, Heidelberg. One selected targets from a new diameter limited ($\\Phi \\ge 5''$) catalog with morphological criteria while the other used digitized objective prism Schmidt plates to select mainly HII dwarf galaxies. For some 450 galaxies, redshifts and other optical data were obtained. We studied the spatial distribution of the sample objects, their luminosity function, and their intrinsic properties. Most of the galaxies belong to already well known sheets and filaments. But we found about a dozen highly isolated galaxies in each sample (nearest neighborhood distance $\\ge 3 h_{75}^{-1} Mpc$). These tend to populate additional structures and are not distributed homogeneously throughout the voids. As our results on 'void galaxies' still suffer from small sample statistics, I also tried to combine similar existing surveys of nearby voids to get further hints on the larger structure and on the luminosit...

  9. Void growth in metals: Atomistic calculations

    Energy Technology Data Exchange (ETDEWEB)

    Traiviratana, Sirirat [Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92093 (United States); Bringa, Eduardo M. [Materials Science Department, Lawrence Livermore National Laboratory, Livermore, CA 94550 (United States); Benson, David J. [Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92093 (United States); Meyers, Marc A. [Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92093 (United States); NanoEngineering, University of California, San Diego, La Jolla, CA 92093 (United States)], E-mail: mameyers@ucsd.edu

    2008-09-15

    Molecular dynamics simulations in monocrystalline and bicrystalline copper were carried out with LAMMPS (Large-scale Atomic/Molecular Massively Parallel Simulator) to reveal void growth mechanisms. The specimens were subjected to tensile uniaxial strains; the results confirm that the emission of (shear) loops is the primary mechanism of void growth. It is observed that many of these shear loops develop along two slip planes (and not one, as previously thought), in a heretofore unidentified mechanism of cooperative growth. The emission of dislocations from voids is the first stage, and their reaction and interaction is the second stage. These loops, forming initially on different {l_brace}1 1 1{r_brace} planes, join at the intersection, if the Burgers vector of the dislocations is parallel to the intersection of two {l_brace}1 1 1{r_brace} planes: a <1 1 0> direction. Thus, the two dislocations cancel at the intersection and a biplanar shear loop is formed. The expansion of the loops and their cross slip leads to the severely work-hardened region surrounding a growing void. Calculations were carried out on voids with different sizes, and a size dependence of the stress threshold to emit dislocations was obtained by MD, in disagreement with the Gurson model which is scale independent. This disagreement is most marked for the nanometer sized voids. The scale dependence of the stress required to grow voids is interpreted in terms of the decreasing availability of optimally oriented shear planes and increased stress required to nucleate shear loops as the void size is reduced. The growth of voids simulated by MD is compared with the Cocks-Ashby constitutive model and significant agreement is found. The density of geometrically necessary dislocations as a function of void size is calculated based on the emission of shear loops and their outward propagation. Calculations are also carried out for a void at the interface between two grains to simulate polycrystalline

  10. Cardiac mechanics and dysfunction with anthracyclines in the community: results from the PREDICT study

    Science.gov (United States)

    Narayan, Hari K; Wei, Wei; Feng, Ziding; Lenihan, Daniel; Plappert, Ted; Englefield, Virginia; Fisch, Michael; Ky, Bonnie

    2017-01-01

    Background Our objective was to determine the relevance of changes in myocardial mechanics in diagnosing and predicting cancer therapeutics-related cardiac dysfunction (CTRCD) in a community-based population treated with anthracyclines. Methods Quantitative measures of cardiac mechanics were derived from 493 echocardiograms in 165 participants enrolled in the PREDICT study (A Multicenter Study in Patients Undergoing AnthRacycline-Based Chemotherapy to Assess the Effectiveness of Using Biomarkers to Detect and Identify Cardiotoxicity and Describe Treatment). Echocardiograms were obtained primarily at baseline (prior to anthracyclines), 6 and 12 months. Predictors included changes in strain; strain rate; indices of contractile function derived from the end-systolic pressure–volume relationship (end-systolic elastance (Eessb) and the left ventricular (LV) volume at an end-systolic pressure of 100 mm Hg (V100)); total arterial load (effective arterial elastance (Ea)) and ventricular–arterial coupling (Ea/Eessb). Logistic regression models determined the diagnostic and prognostic associations of changes in these measures and CTRCD, defined as a LV ejection fraction decline ≥10 to mechanics are diagnostic and predictive of cardiac dysfunction with anthracycline chemotherapy in community populations. Our findings support the non-invasive assessment of measures of myocardial mechanics more broadly in clinical practice and emphasise the role of serial assessments of these measures during and after cardiotoxic cancer therapy. Trial registration number NCT01032278; Pre-results. PMID:28123764

  11. Diffusion tensor imaging and tractography for assessment of renal allograft dysfunction - initial results

    Energy Technology Data Exchange (ETDEWEB)

    Hueper, Katja; Gutberlet, M.; Rodt, T.; Wacker, F.; Galanski, M.; Hartung, D. [Institute for Diagnostic and Interventional Radiology, Hannover Medical School - Germany, Hannover (Germany); Gwinner, W. [Clinic for Nephrology, Hannover Medical School - Germany, Hannover (Germany); Lehner, F. [Clinic for General, Abdominal and Transplant Surgery, Hannover Medical School - Germany, Hannover (Germany)

    2011-11-15

    To evaluate MR diffusion tensor imaging (DTI) as non-invasive diagnostic tool for detection of acute and chronic allograft dysfunction and changes of organ microstructure. 15 kidney transplanted patients with allograft dysfunction and 14 healthy volunteers were examined using a fat-saturated echo-planar DTI-sequence at 1.5 T (6 diffusion directions, b = 0, 600 s/mm{sup 2}). Mean apparent diffusion coefficient (ADC) and mean fractional anisotropy (FA) were calculated separately for the cortex and for the medulla and compared between healthy and transplanted kidneys. Furthermore, the correlation between diffusion parameters and estimated GFR was determined. The ADC in the cortex and in the medulla were lower in transplanted than in healthy kidneys (p < 0.01). Differences were more distinct for FA, especially in the renal medulla, with a significant reduction in allografts (p < 0.001). Furthermore, in transplanted patients a correlation between mean FA in the medulla and estimated GFR was observed (r = 0.72, p < 0.01). Tractography visualized changes in renal microstructure in patients with impaired allograft function. Changes in allograft function and microstructure can be detected and quantified using DTI. However, to prove the value of DTI for standard clinical application especially correlation of imaging findings and biopsy results is necessary. (orig.)

  12. The view from the boundary: a new void stacking method

    CERN Document Server

    Cautun, Marius; Frenk, Carlos S

    2015-01-01

    We introduce a new method for stacking voids and deriving their profile that greatly increases the potential of voids as a tool for precision cosmology. Given that voids are highly non-spherical and have most of their mass at their edge, voids are better described relative to their boundary rather than relative to their centre, as in the conventional spherical stacking approach. The boundary profile is obtained by computing the distance of each volume element from the void boundary. Voids can then be stacked and their profiles computed as a function of this boundary distance. This approach enhances the weak lensing signal of voids, both shear and convergence, by a factor of two when compared to the spherical stacking method. It also results in steeper void density profiles that are characterised by a very slow rise inside the void and a pronounced density ridge at the void boundary, in qualitative agreement with theoretical models of expanding spherical underdensities. The resulting boundary density profile i...

  13. Void Reactivity Coefficient Analysis during Void Fraction Changes in Innovative BWR Assemblies

    Directory of Open Access Journals (Sweden)

    Andrius Slavickas

    2015-01-01

    Full Text Available The study of the void reactivity variation in innovative BWR fuel assemblies is presented in this paper. The innovative assemblies are loaded with high enrichment fresh UO2 and MOX fuels. UO2 fuel enrichment is increased above existing design limitations for LWR fuels (>5%. MOX fuel enrichment with fissile Pu content is established to achieve the same burnup level as that of high enrichment UO2 fuel. For the numerical analysis, the TRITON functional module of SCALE 6.1 code with the 238-group ENDF/B-VI cross section data library was applied. The investigation of the void reactivity feedback is performed in the entire 0–100% void fraction range. Higher values of void reactivity coefficient for assembly loaded with MOX fuel are found in comparison with values for assembly loaded with UO2 fuel. Moreover, coefficient values for MOX fuel are positive over 75% void fraction. The variation of the void reactivity coefficient is explained by the results of the decomposition analysis based on four-factor formula and neutron absorption reactions for main isotopes. Additionally, the impact of the moderation enhancement on the void reactivity coefficient was investigated for the innovative assembly with MOX fuel.

  14. Targeting Palmitoyl acyltransferase ZDHHC21 Improves Gut Epithelial Barrier Dysfunction Resulting from Burn Induced Systemic Inflammation.

    Science.gov (United States)

    Haines, Ricci J; Wang, Chunyan; Yang, Clement Gy; Eitnier, Rebecca A; Wang, Fang; Wu, Mack H

    2017-08-24

    Clinical studies in burn patients demonstrate a close association between leaky guts and increased incidence or severity of sepsis and other complications. Severe thermal injury triggers intestinal inflammation that contributes to intestinal epithelial hyperpermeability, which exacerbates systemic response leading to multiple organ failure and sepsis. In this study, we identified a significant function of a particular palmitoyl acyltransferase (PAT), ZDHHC21, in mediating signaling events required for gut hyperpermeability induced by inflammation. Using qPCR, we show that ZDHHC21 mRNA, production was enhanced by two-fold when intestinal epithelial cells were treated with TNFα/IFNγ in vitro. In addition, pharmacological targeting of PATs with 2-bromopalmitate (2-BP) showed significant improvement in TNFα/IFNγ mediated epithelial barrier dysfunction by using electric cell-substrate impedance sensing (ECIS) assays, as well as FITC-dextran permeability assays. Using the ABE assay and click chemistry, we show that TNFα/IFNγ treatment of intestinal epithelial cells results in enhanced detection of total palmitoylated proteins, and this response is inhibited by 2-BP. Using ZDHHC21 deficient mice or wild-type mice treated with 2-BP, we showed that mice with impaired ZDHHC21 expression or pharmacological inhibition resulted in attenuated intestinal barrier dysfunction caused by thermal injury. Moreover, H&E staining of small intestine, as well as transmission electron microscopy (TEM), showed mice with genetic interruption of ZDHHC21 had attenuated villus structure disorganization associated with thermal injury induced intestinal barrier damage. Taken together, these results suggest an important role of ZDHHC21 in mediating gut hyperpermeability resulting from thermal injury. Copyright © 2017, American Journal of Physiology-Gastrointestinal and Liver Physiology.

  15. Into the Void

    Science.gov (United States)

    2006-01-01

    17 May 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a portion of a chain of pits on a lava- and dust-covered plain northwest of Tharsis Tholus -- one of the many volcanic constructs in the Tharsis region of Mars. Pit chains, such as this one, are associated with the collapse of surface materials into subsurface voids formed by faulting and expansion -- or extension -- of the bedrock. Location near: 16.4oN, 92.6oW Image width: 3 km (1.9 mi) Illumination from: lower left Season: Northern Winter

  16. Cause Analysis on the Void under Slabs of Cement Concrete Pavement

    Science.gov (United States)

    Wen, Li; Zhu, Guo Xin; Baozhu

    2017-06-01

    This paper made a systematic analysis on the influence of the construction, environment, water and loads on the void beneath road slabs, and also introduced the formation process of structural void and pumping void, and summarizes the deep reasons for the bottom of the cement concrete pavement. Based on the analysis above, this paper has found out the evolution law of the void under slabs which claimed that the void usually appeared in the slab corners and then the cross joint, resulting void in the four sides with the void area under the front slab larger than the rear one.

  17. Baryon effects on void statistics in the EAGLE simulation

    Science.gov (United States)

    Paillas, Enrique; Lagos, Claudia D. P.; Padilla, Nelson; Tissera, Patricia; Helly, John; Schaller, Matthieu

    2017-10-01

    Cosmic voids are promising tools for cosmological tests due to their sensitivity to dark energy, modified gravity and alternative cosmological scenarios. Most previous studies in the literature of void properties use cosmological N-body simulations of dark matter (DM) particles that ignore the potential effect of baryonic physics. Using a spherical underdensity finder, we analyse voids using the mass field and subhalo tracers in the Evolution and Assembly of Galaxies and their Environment (EAGLE) simulations, which follow the evolution of galaxies in a Λ cold dark matter universe with state-of-the-art subgrid models for baryonic processes in a (100 cMpc)3 volume. We study the effect of baryons on void statistics by comparing results with DM-only simulations that use the same initial conditions as EAGLE. When identifying voids in the mass field, we find that a DM-only simulation produces 24 per cent more voids than a hydrodynamical one due to the action of galaxy feedback polluting void regions with hot gas, specially for small voids with rvoid ≤ 10 Mpc. We find that the way in which galaxy tracers are selected has a strong impact on the inferred void properties. Voids identified using galaxies selected by their stellar mass are larger and have cuspier density profiles than those identified by galaxies selected by their total mass. Overall, baryons have minimal effects on void statistics, as void properties are well captured by DM-only simulations, but it is important to account for how galaxies populate DM haloes to estimate the observational effect of different cosmological models on the statistics of voids.

  18. CTF Void Drift Validation Study

    Energy Technology Data Exchange (ETDEWEB)

    Salko, Robert K. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gosdin, Chris [Pennsylvania State Univ., University Park, PA (United States); Avramova, Maria N. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gergar, Marcus [Pennsylvania State Univ., University Park, PA (United States)

    2015-10-26

    This milestone report is a summary of work performed in support of expansion of the validation and verification (V&V) matrix for the thermal-hydraulic subchannel code, CTF. The focus of this study is on validating the void drift modeling capabilities of CTF and verifying the supporting models that impact the void drift phenomenon. CTF uses a simple turbulent-diffusion approximation to model lateral cross-flow due to turbulent mixing and void drift. The void drift component of the model is based on the Lahey and Moody model. The models are a function of two-phase mass, momentum, and energy distribution in the system; therefore, it is necessary to correctly model the ow distribution in rod bundle geometry as a first step to correctly calculating the void distribution due to void drift.

  19. Prenatal lipopolysaccharide exposure results in dysfunction of the renal dopamine D1 receptor in offspring.

    Science.gov (United States)

    Wang, Xinquan; Luo, Hao; Chen, Caiyu; Chen, Ken; Wang, Jialiang; Cai, Yue; Zheng, Shuo; Yang, Xiaoli; Zhou, Lin; Jose, Pedro A; Zeng, Chunyu

    2014-11-01

    Adverse environment in early life can modulate the adult phenotype, including blood pressure. Lipopolysaccharide (LPS) exposure in utero results in increased blood pressure in the offspring, but the exact mechanisms are not clear. Studies have shown that the renal dopamine D1 receptor (D1R) plays an important role in maintaining sodium homeostasis and normal blood pressure; dysfunction of D1R is associated with oxidative stress and hypertension. In this study, we determined if dysfunction of the renal D1R is involved in fetal-programmed hypertension, and if oxidative stress contributes to this process. Pregnant Sprague-Dawley (SD) rats were intraperitoneally injected with LPS (0.79 mg/kg) or saline at gestation days 8, 10, and 12. As compared with saline-injected (control) dams, offspring of LPS-treated dams had increased blood pressure, decreased renal sodium excretion, and increased markers of oxidative stress. In addition, offspring of LPS-treated dams had decreased renal D1R expression, increased D1R phosphorylation, and G protein-coupled receptor kinase type 2 (GRK2) and type 4 (GRK4) protein expression, and impaired D1R-mediated natriuresis and diuresis. All of the findings in the offspring of LPS-treated dams were normalized after treatment with TEMPOL, an oxygen free radical scavenger. In conclusion, prenatal LPS exposure, via an increase in oxidative stress, impairs renal D1R function and leads to hypertension in the offspring. Normalization of renal D1R function by amelioration of oxidative stress may be a therapeutic target of fetal programming of hypertension.

  20. On de-Sitter Geometry in Cosmic Void Statistics

    CERN Document Server

    Gibbons, Gary W; Yoshida, Naoki; Chon, Sunmyon

    2013-01-01

    Starting from the geometrical concept of a 4-dimensional de-Sitter configuration of spheres in Euclidean 3-space and modelling voids in the Universe as spheres, we show that a uniform distribution over this configuration space implies a power-law for the void number density which is consistent with results from the excursion set formalism and from data, for an intermediate range of void volumes. We also discuss the effect of restricting the survey geometry on the void statistics. This work is a new application of de-Sitter geometry to cosmology and also provides a new geometrical perspective on self-similarity in cosmology.

  1. Dynamic imaging of posterior compartment pelvic floor dysfunction by evacuation proctography: Techniques, indications, results and limitations

    Energy Technology Data Exchange (ETDEWEB)

    Maglinte, Dean D.T. [Department of Radiology, Indiana University Medical Center, University Hospital and Outpatient Center, 550 N. University Blvd. UH 0279, Indianapolis, IN 46202 (United States)]. E-mail: dmaglint@iupui.edu; Bartram, Clive [Imperial College Faculty of Medicine, Consulting Radiology, St. Mark' s Hospital, Northwick Park, Harrow HA1 3UJ (United Kingdom)

    2007-03-15

    The clinical management of patients with anorectal and pelvic floor dysfunction is often difficult. Evacuation proctography has evolved from a method to evaluate the anorectum for functional disorders to its current status as a practical method for evaluating anorectal dysfunction and pelvic floor prolapse. It has a high observer accuracy and yield of positive diagnosis. Clinicians find it of major benefit and has altered management from surgical to medical and vice versa in a significant number of cases.

  2. Dynamic imaging of posterior compartment pelvic floor dysfunction by evacuation proctography: techniques, indications, results and limitations.

    Science.gov (United States)

    Maglinte, Dean D T; Bartram, Clive

    2007-03-01

    The clinical management of patients with anorectal and pelvic floor dysfunction is often difficult. Evacuation proctography has evolved from a method to evaluate the anorectum for functional disorders to its current status as a practical method for evaluating anorectal dysfunction and pelvic floor prolapse. It has a high observer accuracy and yield of positive diagnosis. Clinicians find it of major benefit and has altered management from surgical to medical and vice versa in a significant number of cases.

  3. Exercise-induced splanchnic hypoperfusion results in gut dysfunction in healthy men.

    Directory of Open Access Journals (Sweden)

    Kim van Wijck

    Full Text Available BACKGROUND: Splanchnic hypoperfusion is common in various pathophysiological conditions and often considered to lead to gut dysfunction. While it is known that physiological situations such as physical exercise also result in splanchnic hypoperfusion, the consequences of flow redistribution at the expense of abdominal organs remained to be determined. This study focuses on the effects of splanchnic hypoperfusion on the gut, and the relationship between hypoperfusion, intestinal injury and permeability during physical exercise in healthy men. METHODS AND FINDINGS: Healthy men cycled for 60 minutes at 70% of maximum workload capacity. Splanchnic hypoperfusion was assessed using gastric tonometry. Blood, sampled every 10 minutes, was analyzed for enterocyte damage parameters (intestinal fatty acid binding protein (I-FABP and ileal bile acid binding protein (I-BABP. Changes in intestinal permeability were assessed using sugar probes. Furthermore, liver and renal parameters were assessed. Splanchnic perfusion rapidly decreased during exercise, reflected by increased gap(g-apCO(2 from -0.85±0.15 to 0.85±0.42 kPa (p<0.001. Hypoperfusion increased plasma I-FABP (615±118 vs. 309±46 pg/ml, p<0.001 and I-BABP (14.30±2.20 vs. 5.06±1.27 ng/ml, p<0.001, and hypoperfusion correlated significantly with this small intestinal damage (r(S = 0.59; p<0.001. Last of all, plasma analysis revealed an increase in small intestinal permeability after exercise (p<0.001, which correlated with intestinal injury (r(S = 0.50; p<0.001. Liver parameters, but not renal parameters were elevated. CONCLUSIONS: Exercise-induced splanchnic hypoperfusion results in quantifiable small intestinal injury. Importantly, the extent of intestinal injury correlates with transiently increased small intestinal permeability, indicating gut barrier dysfunction in healthy individuals. These physiological observations increase our knowledge of splanchnic hypoperfusion sequelae, and may

  4. Postnatal endocrine dysfunction resulting from prenatal exposure to carbofuran, diazinon or chlordane.

    Science.gov (United States)

    Cranmer, J S; Avery, D L; Grady, R R; Kitay, J I

    1978-01-01

    Prenatal exposure to pesticides of three different classes initiated persistent postnatal endocrine dysfunction. Adrenal function and hepatic metabolism of corticosterone were studied in adult hybrid mice exposed during development to either an organophosphate (Diazinon), a carbamate (Carbofuran), or an organochlorine (Chlordane). Animals were exposed to relatively low levels of the toxins in utero and neonatally via the mothers' milk. Exposure to lower doses of the anticholinesterase compounds, Diazinon or Carbofuran, resulted in impairment of hepatic metabolism of corticosterone in vitro due to a loss in reductive capacity per unit liver weight. Plasma levels of corticosterone were also elevated in these animals, but without a concomitant increase in adrenal steroidogenesis in vitro. The effects of exposure to Chlordane were more complex. In male animals, exposure to lower doses of chlordane resulted in an increase in plasma corticosterone levels without an apparent increase in hepatic metabolism of corticosterone or adrenal steroidogenesis. In contrast, side-chain metabolism of corticosterone was decreased in female mice exposed to Chlordane. Similar effects on pituitary-adrenal function were not evident for the offspring of mice exposed to higher doses of the toxins. Possible mechanisms for this non-linear dose-response are discussed.

  5. Quantifying Effects of Voids in Woven Ceramic Matrix Composites

    Science.gov (United States)

    Goldsmith, Marlana B.; Sankar, Bhavani V.; Haftka, Raphael T.; Goldberg, Robert K.

    2013-01-01

    Randomness in woven ceramic matrix composite architecture has been found to cause large variability in stiffness and strength. The inherent voids are an aspect of the architecture that may cause a significant portion of the variability. A study is undertaken to investigate the effects of many voids of random sizes and distributions. Response surface approximations were formulated based on void parameters such as area and length fractions to provide an estimate of the effective stiffness. Obtaining quantitative relationships between the properties of the voids and their effects on stiffness of ceramic matrix composites are of ultimate interest, but the exploratory study presented here starts by first modeling the effects of voids on an isotropic material. Several cases with varying void parameters were modeled which resulted in a large amount of variability of the transverse stiffness and out-of-plane shear stiffness. An investigation into a physical explanation for the stiffness degradation led to the observation that the voids need to be treated as an entity that reduces load bearing capabilities in a space larger than what the void directly occupies through a corrected length fraction or area fraction. This provides explanation as to why void volume fraction is not the only important factor to consider when computing loss of stiffness.

  6. New Statistical Perspective to The Cosmic Void Distribution

    CERN Document Server

    Pycke, Jean-Renaud

    2016-01-01

    In this study, we obtain the size distribution of voids as a 3-parameter redshift independent log-normal void probability function (VPF) directly from the Cosmic Void Catalog (CVC). Although many statistical models of void distributions are based on the counts in randomly placed cells, the log-normal VPF that we here obtain is independent of the shape of the voids due to the parameter-free void finder of the CVC. We use three void populations drawn from the CVC generated by the Halo Occupation Distribution (HOD) Mocks which are tuned to three mock SDSS samples to investigate the void distribution statistically and the effects of the environments on the size distribution. As a result, it is shown that void size distributions obtained from the HOD Mock samples are satisfied by the 3-parameter log-normal distribution. In addition, we find that there may be a relation between hierarchical formation, skewness and kurtosis of the log-normal distribution for each catalog. We also show that the shape of the 3-paramet...

  7. Experimental and numerical investigation of voids distribution in VPI for ITER correction coil

    Energy Technology Data Exchange (ETDEWEB)

    Li, Juping, E-mail: ljping@ipp.ac.cn; Wu, Jiefeng; Yu, Xiaowu

    2015-06-15

    Highlights: • A sample of correction coil was treated by vacuum pressure impregnation. • The voids in sample were observed by computed tomography. • The voids distributions were simulated in 2-D and 3-D model. • The calculated voids locations had a good agreement with experiment. • The simulation was not accurate in calculating the voids content. - Abstract: The experimental and numerical investigations were conducted to study the voids distribution in VPI (Vacuum Pressure Impregnation) process for correction coil. A sample of correction coil was manufactured by VPI. The voids in sample were observed with computed tomography and the average voids content was tested. The voids content is closely related to infiltration velocity and fluid properties. In former researches, the parameters affecting voids content were combined into a single parameter, namely capillary number. By calculating the capillary numbers in different areas of the sample, the voids distribution could be acquired. The corresponding numerical analyses based on Darcy law were conducted in 2-D and 3-D models. The 2-D case was used to simulate the voids distribution on the section as a simplified model, while the 3-D case demonstrated the spatial distribution of voids. The voids locations were similar in 2-D and 3-D cases, but the voids contents were different. The numerical results were compared with the actual voids distribution in sample. It was found the voids locations were close in numerical and experimental results, but the voids content did not match. The numerical simulations are available for predicting the voids locations in VPI, but not accurate in calculating the voids content.

  8. Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.

    Science.gov (United States)

    Yuen, Michaela; Sandaradura, Sarah A; Dowling, James J; Kostyukova, Alla S; Moroz, Natalia; Quinlan, Kate G; Lehtokari, Vilma-Lotta; Ravenscroft, Gianina; Todd, Emily J; Ceyhan-Birsoy, Ozge; Gokhin, David S; Maluenda, Jérome; Lek, Monkol; Nolent, Flora; Pappas, Christopher T; Novak, Stefanie M; D'Amico, Adele; Malfatti, Edoardo; Thomas, Brett P; Gabriel, Stacey B; Gupta, Namrata; Daly, Mark J; Ilkovski, Biljana; Houweling, Peter J; Davidson, Ann E; Swanson, Lindsay C; Brownstein, Catherine A; Gupta, Vandana A; Medne, Livija; Shannon, Patrick; Martin, Nicole; Bick, David P; Flisberg, Anders; Holmberg, Eva; Van den Bergh, Peter; Lapunzina, Pablo; Waddell, Leigh B; Sloboda, Darcée D; Bertini, Enrico; Chitayat, David; Telfer, William R; Laquerrière, Annie; Gregorio, Carol C; Ottenheijm, Coen A C; Bönnemann, Carsten G; Pelin, Katarina; Beggs, Alan H; Hayashi, Yukiko K; Romero, Norma B; Laing, Nigel G; Nishino, Ichizo; Wallgren-Pettersson, Carina; Melki, Judith; Fowler, Velia M; MacArthur, Daniel G; North, Kathryn N; Clarke, Nigel F

    2014-11-01

    Nemaline myopathy (NM) is a genetic muscle disorder characterized by muscle dysfunction and electron-dense protein accumulations (nemaline bodies) in myofibers. Pathogenic mutations have been described in 9 genes to date, but the genetic basis remains unknown in many cases. Here, using an approach that combined whole-exome sequencing (WES) and Sanger sequencing, we identified homozygous or compound heterozygous variants in LMOD3 in 21 patients from 14 families with severe, usually lethal, NM. LMOD3 encodes leiomodin-3 (LMOD3), a 65-kDa protein expressed in skeletal and cardiac muscle. LMOD3 was expressed from early stages of muscle differentiation; localized to actin thin filaments, with enrichment near the pointed ends; and had strong actin filament-nucleating activity. Loss of LMOD3 in patient muscle resulted in shortening and disorganization of thin filaments. Knockdown of lmod3 in zebrafish replicated NM-associated functional and pathological phenotypes. Together, these findings indicate that mutations in the gene encoding LMOD3 underlie congenital myopathy and demonstrate that LMOD3 is essential for the organization of sarcomeric thin filaments in skeletal muscle.

  9. Prevalence of elimination dysfunction, among primary school age children in Sari

    Directory of Open Access Journals (Sweden)

    M. Basiri,

    2008-01-01

    Full Text Available AbstractBackground and Purpose: Elimination dysfunction is referred to have various difficulties in urination and defecation, such as urinary frequency, delayed with difficulty in voiding or defecation. The prevalence of elimination dysfunction has been varied in different studies, as 21% of children experience elimination dysfunction during their childhood period. Presently, there are no studies pertaining to this difficulty in our country. Therefore, we carried out a descriptive study in primary schools from the Sari Township, regarding voiding and defecation dysfunction among children, and also we identified the epidemiology of the disease, in order to solve problems by implementing teaching programs and screening methods.Materials and Methods: This cross-sectional study was done on Primary school age students in the Sari Township, during 2007 through 2008. Considering the prevalence of elimination dysfunction (15-25%, confidence coefficient 95%, SE 10%, and the sample size of 2,200 were randomly and equally selected from different parts of the township among the two-sex groups. A standard questionnaire including demographic characteristics and 10 questions on voiding status, in addition to 19 questions regarding defecation status was prepared. Questionnaires were distributed to the students by responsible school personnel and then referred to parents for completion. Data was analyzed by SPSS software and descriptive statistics (Frequency, Mean, and Standard Deviation. Chi Square test (χ² and Student T-test were used to compare the Means. P<0.05 was considered significant.Results: Of 2201 primary school age students, 48.7% were girls. The mean age was 8.96±1.43 year. Voiding and defecation dysfunction was reported in 38.4% and 29% of the cases respectively. There was no significant relationship between prevalence of voiding dysfunction and other factors such as mean age, sex and level of education; however, there was a significant

  10. Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death, and early mortality in zebrafish

    Science.gov (United States)

    Mishra, Shikha; Guan, Jian; Plovie, Eva; Seldin, David C.; Connors, Lawreen H.; Merlini, Giampaolo; Falk, Rodney H.; MacRae, Calum A.

    2013-01-01

    Systemic amyloid light-chain (AL) amyloidosis is associated with rapidly progressive and fatal cardiomyopathy resulting from the direct cardiotoxic effects of circulating AL light chain (AL-LC) proteins and the indirect effects of AL fibril tissue infiltration. Cardiac amyloidosis is resistant to standard heart failure therapies, and, to date, there are limited treatment options for these patients. The mechanisms underlying the development of cardiac amyloidosis and AL-LC cardiotoxicity are largely unknown, and their study has been limited by the lack of a suitable in vivo model system. Here, we establish an in vivo zebrafish model of human AL-LC-induced cardiotoxicity. AL-LC isolated from AL cardiomyopathy patients or control nonamyloidogenic LC protein isolated from multiple myeloma patients (Con-LC) was directly injected into the circulation of zebrafish at 48 h postfertilization. AL-LC injection resulted in impaired cardiac function, pericardial edema, and increased cell death relative to Con-LC, culminating in compromised survival with 100% mortality within 2 wk, independent of AL fibril deposition. Prior work has implicated noncanonical p38 MAPK activation in the pathogenesis of AL-LC-induced cardiotoxicity, and p38 MAPK inhibition via SB-203580 rescued AL-LC-induced cardiac dysfunction and cell death and attenuated mortality in zebrafish. This in vivo zebrafish model of AL-LC cardiotoxicity demonstrates that antagonism of p38 MAPK within the AL-LC cardiotoxic signaling response may serve to improve cardiac function and mortality in AL cardiomyopathy. Furthermore, this in vivo model system will allow for further study of the molecular underpinnings of AL cardiotoxicity and identification of novel therapeutic strategies. PMID:23624626

  11. The relationship between void waves and flow regime transition

    Energy Technology Data Exchange (ETDEWEB)

    Lahey, R.T. Jr.; Drew, D.A.; Kalkach-Navarro, S.; Park, J.W.

    1992-12-31

    The results of an extensive experimental and analytical study on the relationship between void waves and flow regime transition are presented, in particular, the bubbly/slug flow regime transition. It is shown that void wave instability signals a flow regime transition.

  12. Testing Gravity using Void Profiles

    Science.gov (United States)

    Cai, Yan-Chuan; Padilla, Nelson; Li, Baojiu

    2016-10-01

    We investigate void properties in f(R) models using N-body simulations, focusing on their differences from General Relativity (GR) and their detectability. In the Hu-Sawicki f(R) modified gravity (MG) models, the halo number density profiles of voids are not distinguishable from GR. In contrast, the same f(R) voids are more empty of dark matter, and their profiles are steeper. This can in principle be observed by weak gravitational lensing of voids, for which the combination of a spectroscopic redshift and a lensing photometric redshift survey over the same sky is required. Neglecting the lensing shape noise, the f(R) model parameter amplitudes fR0=10-5 and 10-4 may be distinguished from GR using the lensing tangential shear signal around voids by 4 and 8 σ for a volume of 1 (Gpc/h)3. The line-of-sight projection of large-scale structure is the main systematics that limits the significance of this signal for the near future wide angle and deep lensing surveys. For this reason, it is challenging to distinguish fR0=10-6 from GR. We expect that this can be overcome with larger volume. The halo void abundance being smaller and the steepening of dark matter void profiles in f(R) models are unique features that can be combined to break the degeneracy between fR0 and σ8.

  13. Indication, methods and results of selective arteriography of the A. iliaca interna in case of erectile dysfunction

    Energy Technology Data Exchange (ETDEWEB)

    Baehren, W.; Gall, H.; Scherb, W.; Thon, W.

    1988-01-01

    Erectile dysfunction very frequently can be traced back to the real cause by means of angiography. Selective angiography is the method of choice in cases where other causes of circulatory disturbance have already been excluded, and non-invasive tests are expected to yield information of relevance to therapy. The qualitatively best angiographic results are obtained by examination under peridural anesthesia and by intracavitary injection of vaso-active substances. Selective arteriography is indicated in cases of primary or post-traumatic erectile dysfunction. It is a prerequisite of surgery for revascularisation of the pudendal-penile vascular bed.

  14. Predictive modelling for swallowing dysfunction after primary (chemo)radiation : Results of a prospective observational study

    NARCIS (Netherlands)

    Christianen, Miranda E M C; Schilstra, Cornelis; Beetz, Ivo; Muijs, C.T.; Chouvalova, Olga; Burlage, Fred R.; Doornaert, P.; Koken, P.W.; Leemans, C.R.; Rinkel, R.N.; de Bruijn, M.J.; de Bock, G.H.; Roodenburg, J.L.; van der Laan, B.F.; Slotman, B.J.; Verdonck-de Leeuw, I.M.; Bijl, Hendrik P.; Langendijk, J.A.

    2012-01-01

    Background and purpose: The purpose of this large multicentre prospective cohort study was to identify which dose volume histogram parameters and pre-treatment factors are most important to predict physician-rated and patient-rated radiation-induced swallowing dysfunction (RISD) in order to develop

  15. The place of female sexual dysfunction in the urological practice : Results of a Dutch Survey

    NARCIS (Netherlands)

    Bekker, Milou; Beck, Jacky; Putter, Hein; van Driel, Mels; Pelger, Rob; Nijeholt, August Lycklama A.; Elzevier, Henk

    2009-01-01

    Introduction. Female sexual dysfunction (FSD) is a highly prevalent and often underestimated problem. There is a strong association between urological complaints and FSD. Aims. The purpose of this survey was to evaluate how Dutch urologists address FSD in their daily practice. Methods. We performed

  16. Promising results after balloon dilatation of the Eustachian tube for obstructive dysfunction

    DEFF Research Database (Denmark)

    Wanscher, Jens H; Svane-Knudsen, Viggo

    2014-01-01

    INTRODUCTION: As the first ear, nose and throat department in Denmark, we introduced balloon dilatation of the Eustachian tube as a treatment of obstructive dysfunction in the summer of 2012. We present our preliminary experiences with this new treatment in adults. MATERIAL AND METHODS: Preoperat...

  17. The Instability of Void Fraction Waves in Vertical Gas—Liquid Two—Phase Flow

    Institute of Scientific and Technical Information of China (English)

    BaojiangSUN; DachunYAN; 等

    1999-01-01

    The measuring and analyzing results of void fraction waves in different flow regimes show that the propagating velocity of void fraction waves depends on flow regimes and mean void fraction.The disturbance at some frequencies can enhance the void fraction wave velocity.Non-linear analysis show that the instability process of bubble flow is a chaotic process.Before the bubbly flow transits to cap-bubbly flow the growth rate of void fraction waves becomes the maximum value when the disturbance frequency is around the main frequency of void fraction waves.

  18. Effects of Cure Pressure Induced Voids on the Mechanical Strength of Carbon/Epoxy Laminates

    Institute of Scientific and Technical Information of China (English)

    Ling LIU; Boming ZHANG; Zhanjun WU; Dianfu WANG

    2005-01-01

    This work aims at designing a set of curing pressure routes to produce laminates with various void contents. The effects of various consolidation pressures resulting in different void contents on mechanical strength of carbon/epoxy laminates have been examined. Characterization of the voids, in terms of void volume fraction, void distribution,size, and shape, was performed by standard test, ultrasonic inspection and metallographic analysis. The interlaminar shear strength was measured by the short-beam method. An empirical model was used to predict the strength vs porosity. The predicted strengths conform well with the experimental data and voids were found to be uniformly distributed throughout the laminate.

  19. Locating voids beneath pavement using pulsed electromagnetic waves

    Science.gov (United States)

    Steinway, W. J.; Echard, J. D.; Luke, C. M.

    1981-11-01

    The feasibility of using pulsed electromagnetic wave technology for locating and sizing voids beneath reinforced and nonreinforced portland cement concrete pavements is determined. The data processing techniques developed can be implemented to provide information for void depth and sizing to + or - 1/2 in. and spatial location within + or - 6 in. A very short pulse radar directly connected to a microcomputer was chosen as the equipment necessary to obtain measurements. This equipment has the required accuracy and reliability, and is a cost effective solution for the void locating problem. The radar provides a signal return from voids that has unique characteristics that can be examined to provide information regarding the location, depth, and shape of the void. The microcomputer provides a means of real time processing to extract the information from the radar signal return and record the results. Theoretical modeling of signal returns from voids led to suitable techniques for locating and sizing voids beneath the pavement. Analysis and application of these techniques to radar measurements verified the theoretical predictions that radar can be used to determine the location, size, and shape of actual voids.

  20. Geometry and scaling of cosmic voids

    CERN Document Server

    Gaite, Jose

    2008-01-01

    CONTEXT: Cosmic voids are observed in the distribution of galaxies and, to some extent, in the dark matter distribution. If these distributions have fractal geometry, it must be reflected in the geometry of voids; in particular, we expect scaling sizes of voids. However, this scaling is not well demonstrated in galaxy surveys yet. AIMS: Our objective is to understand the geometry of cosmic voids in relation to a fractal structure of matter. We intend to distinguish monofractal voids from multifractal voids, regarding their scaling properties. We plan to analyse voids in the distributions of mass concentrations (halos) in a multifractal and their relation to galaxy voids. METHODS: We make a statistical analysis of point distributions based on the void probability function and correlation functions. We assume that voids are spherical and devise a simple spherical void finder. For continuous mass distributions, we employ the methods of fractal geometry. We confirm the analytical predictions with numerical simula...

  1. Three-Dimensional Molecular Dynamics Simulations of Void Coalescence during Dynamic Fracture of Ductile Metals

    Energy Technology Data Exchange (ETDEWEB)

    Seppala, E T; Belak, J; Rudd, R E

    2004-09-02

    Void coalescence and interaction in dynamic fracture of ductile metals have been investigated using three-dimensional strain-controlled multi-million atom molecular dynamics simulations of copper. The correlated growth of two voids during the coalescence process leading to fracture is investigated, both in terms of its onset and the ensuing dynamical interactions. Void interactions are quantified through the rate of reduction of the distance between the voids, through the correlated directional growth of the voids, and through correlated shape evolution of the voids. The critical inter-void ligament distance marking the onset of coalescence is shown to be approximately one void radius based on the quantification measurements used, independent of the initial separation distance between the voids and the strain-rate of the expansion of the system. The interaction of the voids is not reflected in the volumetric asymptotic growth rate of the voids, as demonstrated here. Finally, the practice of using a single void and periodic boundary conditions to study coalescence is examined critically and shown to produce results markedly different than the coalescence of a pair of isolated voids.

  2. Voids and superstructures: correlations and induced large-scale velocity flows

    Science.gov (United States)

    Lares, Marcelo; Luparello, Heliana E.; Maldonado, Victoria; Ruiz, Andrés N.; Paz, Dante J.; Ceccarelli, Laura; Garcia Lambas, Diego

    2017-09-01

    The expanding complex pattern of filaments, walls and voids build the evolving cosmic web with material flowing from underdense on to high density regions. Here, we explore the dynamical behaviour of voids and galaxies in void shells relative to neighbouring overdense superstructures, using the Millenium simulation and the main galaxy catalogue in Sloan Digital Sky Survey data. We define a correlation measure to estimate the tendency of voids to be located at a given distance from a superstructure. We find voids-in-clouds (S-types) preferentially located closer to superstructures than voids-in-voids (R-types) although we obtain that voids within ∼40 h-1 Mpc of superstructures are infalling in a similar fashion independently of void type. Galaxies residing in void shells show infall towards the closest superstructure, along with the void global motion, with a differential velocity component depending on their relative position in the shell with respect to the direction to the superstructure. This effect is produced by void expansion and therefore is stronger for R-types. We also find that galaxies in void shells facing the superstructure flow towards the overdensities faster than galaxies elsewhere at the same relative distance to the superstructure. The results obtained for the simulation are also reproduced for the Sky Survey Data Release data with a linearized velocity field implementation.

  3. Comparison of voiding cystourethrography and urosonography with second-generation contrast agents in simultaneous prospective study

    Science.gov (United States)

    Świętoń, Dominik; Rybczyńska, Dorota; Czarniak, Piotr; Szarmach, Arkadiusz; Kaszubowski, Mariusz; Szurowska, Edyta

    2016-01-01

    Background The invasiveness and exposure to radiation in voiding cystourethrography led to the introduction of alternative methods of diagnosis of vesicoureteral reflux, including contrast enhanced voiding urosonography. While there is a limited number of studies comparing these methods using new generation ultrasound contrast agents, none of them compared both methods simultaneously. This study is aimed at assessing agreement between contrast enhanced voiding urosonography with second-generation ultrasound contrast agents and voiding cystourethrography. Methods From April 2013 to May 2014, 83 children (37 female and 46 male), mean age 3.5 years, age range from 1 month to 17.5 years, underwent prospective simultaneous assessment by contrast enhanced voiding urosonography and voiding cystourethrography, with a total of 166 uretero-renal units evaluated. Results The sensitivity of voiding cystourethrography and contrast enhanced voiding urosonography were comparable, amounting to 88%, however, neither reached 100% for the entire studied population. The negative predictive value of voiding urosonography and voiding cystourethrography was 97%, and there was no difference between both methods. Conclusion Voiding cystourethrography and contrast enhanced voiding urosonography are comparable methods in diagnosis of vesicoureteral reflux, and can be performed alternatively. However, some limitations of contrast enhanced voiding urosonography must be remembered.

  4. On cavitation instabilities with interacting voids

    DEFF Research Database (Denmark)

    Tvergaard, Viggo

    2012-01-01

    voids so far apart that the radius of the plastic zone around each void is less than 1% of the current spacing between the voids, can still affect each others at the occurrence of a cavitation instability such that one void stops growing while the other grows in an unstable manner. On the other hand...

  5. Alignment of voids in the cosmic web

    NARCIS (Netherlands)

    Platen, Erwin; van de Weygaert, Rien; Jones, Bernard J. T.

    2008-01-01

    We investigate the shapes and mutual alignment of voids in the large-scale matter distribution of a Lambda cold dark matter (Lambda CDM) cosmology simulation. The voids are identified using the novel watershed void finder (WVF) technique. The identified voids are quite non-spherical and slightly pro

  6. Alignment of voids in the cosmic web

    NARCIS (Netherlands)

    Platen, Erwin; van de Weygaert, Rien; Jones, Bernard J. T.

    2008-01-01

    We investigate the shapes and mutual alignment of voids in the large-scale matter distribution of a Lambda cold dark matter (Lambda CDM) cosmology simulation. The voids are identified using the novel watershed void finder (WVF) technique. The identified voids are quite non-spherical and slightly

  7. Treatment of accommodative dysfunction in children: results from a randomized clinical trial.

    Science.gov (United States)

    Scheiman, Mitchell; Cotter, Susan; Kulp, Marjean Taylor; Mitchell, G Lynn; Cooper, Jeffrey; Gallaway, Michael; Hopkins, Kristine B; Bartuccio, Mary; Chung, Ida

    2011-11-01

    To report the effectiveness of various forms of vision therapy/orthoptics in improving accommodative amplitude and facility in children with symptomatic convergence insufficiency (CI) and co-existing accommodative dysfunction. In a randomized clinical trial, 221 children aged 9 to 17 years with symptomatic CI were assigned to one of four treatments. Of the enrolled children, 164 (74%) had accommodative dysfunction; 63 (29%) had a decreased amplitude of accommodation with respect to age, 43 (19%) had decreased accommodative facility, and 58 (26%) had both. Analysis of variance models were used to compare mean accommodative amplitude and accommodative facility for each treatment group after 4, 8, and 12 weeks of treatment. After 12 weeks of treatment, the increases in amplitude of accommodation [office-based vergence/accommodative therapy with home reinforcement group (OBVAT) 9.9 D, home-based computer vergence/accommodative therapy group (HBCVAT+) 6.7 D, and home-based pencil push-up therapy group (HBPP) 5.8 D] were significantly greater than in the office-based placebo therapy (OBPT) group (2.2 D) (p-values ≤0.010). Significant increases in accommodative facility were found in all groups (OBVAT: 9 cpm, HBCVAT+: 7 cpm, HBPP: 5 cpm, OBPT: 5.5 cpm); only the improvement in the OBVAT group was significantly greater than that found in the OBPT group (p = 0.016). One year after completion of therapy, reoccurrence of decreased accommodative amplitude was present in only 12.5% and accommodative facility in only 11%. Vision therapy/orthoptics is effective in improving accommodative amplitude and accommodative facility in school-aged children with symptomatic CI and accommodative dysfunction.

  8. The Void Galaxy Survey: Galaxy Evolution and Gas Accretion in Voids

    Science.gov (United States)

    Kreckel, Kathryn; van Gorkom, Jacqueline H.; Beygu, Burcu; van de Weygaert, Rien; van der Hulst, J. M.; Aragon-Calvo, Miguel A.; Peletier, Reynier F.

    2016-10-01

    Voids represent a unique environment for the study of galaxy evolution, as the lower density environment is expected to result in shorter merger histories and slower evolution of galaxies. This provides an ideal opportunity to test theories of galaxy formation and evolution. Imaging of the neutral hydrogen, central in both driving and regulating star formation, directly traces the gas reservoir and can reveal interactions and signs of cold gas accretion. For a new Void Galaxy Survey (VGS), we have carefully selected a sample of 59 galaxies that reside in the deepest underdensities of geometrically identified voids within the SDSS at distances of ~100 Mpc, and pursued deep UV, optical, Hα, IR, and HI imaging to study in detail the morphology and kinematics of both the stellar and gaseous components. This sample allows us to not only examine the global statistical properties of void galaxies, but also to explore the details of the dynamical properties. We present an overview of the VGS, and highlight key results on the HI content and individually interesting systems. In general, we find that the void galaxies are gas rich, low luminosity, blue disk galaxies, with optical and HI properties that are not unusual for their luminosity and morphology. We see evidence of both ongoing assembly, through the gas dynamics between interacting systems, and significant gas accretion, seen in extended gas disks and kinematic misalignments. The VGS establishes a local reference sample to be used in future HI surveys (CHILES, DINGO, LADUMA) that will directly observe the HI evolution of void galaxies over cosmic time.

  9. Void structure of concrete with superabsorbent polymers and its relation to frost resistance of concrete

    DEFF Research Database (Denmark)

    Hasholt, Marianne Tange; Jensen, Ole Mejlhede; Laustsen, Sara

    2013-01-01

    the difference between poor and satisfactory frost-resistance. Furthermore, the results indicate that voids created directly by SAP protect concrete against frost deterioration just like other air voids; if the concrete contains enough SAP voids, these alone can provide sufficient frost resistance. © 2013 RILEM....

  10. The Influence of the Presence of Multiple Voids on the Discharge Patterns in Solid Epoxy Insulation

    DEFF Research Database (Denmark)

    Holbøll, Joachim T.; Henriksen, Mogens; Larsen, Esben

    1996-01-01

    In this paper, partial discharge test results from initial long term testing on samples which contain more voids, when exposed to a high electric stress will be presented. The influence on the discharge patterns, phase- and height-analyses, of such parameter as the number of voids and the void di...

  11. Precision cosmography with stacked voids

    CERN Document Server

    Lavaux, Guilhem

    2011-01-01

    We present a purely geometrical method for probing the expansion history of the Universe from the observation of the shape of stacked voids in spectroscopic re dshift surveys. Our method is an Alcock-Pasczinsky test based on the average sphericity of voids posited on the local isotropy of the Universe. It works by comparing the temporal extent of cosmic voids along the line of sight with their angular, spatial extent. We describe the algorithm that we use to detect and stack voids in redshift shells on the light cone and test it on mock light cones produced from N-body simulations. We establish a robust statistical model for estimating the average stretching of voids in redshift space and quantify the contamination by peculiar velocities. Finally, we assess the capability of this approach to constrain dark energy parameters in terms of the figure of merit (FoM) of the dark energy task force and in particular of the proposed Euclid mission which is particularly suited for this technique since it is a spectrosc...

  12. DISRUPTION OF ARABIDOPSIS RETICULON GENE RTNLB16 RESULTS IN CHLOROPLAST DYSFUNCTION AND OXIDATIVE STRESS

    Directory of Open Access Journals (Sweden)

    Tarasenko V.I.

    2012-08-01

    dysfunction and resembles the phenotype of plants with inactivated genes encoding chloroplast proteins. The study of reactive oxygen species (ROS level revealed the significantly elevated superoxide content in the mutant plant leaves. Moreover, the measurement of enzymatic activity of different superoxide dismutase isoforms showed an increased level of CuZnSOD which is localized predominantly in chloroplasts. At the same time, the level of mitochondria-localized MnSOD remained unchanged. This fact also points to chloroplasts as a potential source of increased ROS content in mutant plants. To test this hypothesis, we studied the ROS level in the guard cells of mutant and wild-type plants. As a result, the significant increase of chloroplast-derived ROS content in guard cells of mutant plants was showed. Therefore, we conclude that an inactivation of the RTNLB16 gene leads to severe defects in chloroplast functioning and assotiated oxidative stress. We suppose that RTNLB16 protein participates in interactions between chloroplasts and other intracellular structures.

  13. Repeated exposure to heat stress results in a diaphragm phenotype that resists ventilator-induced diaphragm dysfunction.

    Science.gov (United States)

    Yoshihara, Toshinori; Ichinoseki-Sekine, Noriko; Kakigi, Ryo; Tsuzuki, Takamasa; Sugiura, Takao; Powers, Scott K; Naito, Hisashi

    2015-11-01

    Controlled mechanical ventilation (CMV) is a life-saving intervention for patients in respiratory failure. Unfortunately, prolonged mechanical ventilation (MV) results in diaphragmatic atrophy and contractile dysfunction, both of which are predicted to contribute to problems in weaning patients from the ventilator. Therefore, developing a strategy to protect the diaphragm against ventilator-induced weakness is important. We tested the hypothesis that repeated bouts of heat stress result in diaphragm resistance against CMV-induced atrophy and contractile dysfunction. Male Wistar rats were randomly divided into six experimental groups: 1) control; 2) single bout of whole body heat stress; 3) repeated bouts of whole body heat stress; 4) 12 h CMV; 5) single bout of whole body heat stress 24 h before CMV; and 6) repeated bouts of whole body heat stress 1, 3, and 5 days before 12 h of CMV. Our results revealed that repeated bouts of heat stress resulted in increased levels of heat shock protein 72 in the diaphragm and protection against both CMV-induced diaphragmatic atrophy and contractile dysfunction at submaximal stimulation frequencies. The specific mechanisms responsible for this protection remain unclear: this heat stress-induced protection against CMV-induced diaphragmatic atrophy and weakness may be partially due to reduced diaphragmatic oxidative stress, diminished activation of signal transducer/transcriptional activator-3, lower caspase-3 activation, and decreased autophagy in the diaphragm.

  14. Diabetic bladder dysfunction

    Institute of Scientific and Technical Information of China (English)

    Guiming Liu; Firouz Daneshgari

    2014-01-01

    Objective To review studies on diabetic bladder dysfunction (DBD),a common and bothersome complication of diabetes mellitus.Data sources We performed a search of the English literature through PubMed.The key words used were "diabetes" and "bladder dysfunction" or "cystopathy".Our own data and perspective are included in the discussion.Study selection Studies containing data relevant to DBD were selected.Because of the limited length of this article,we also referenced reviews that contain comprehensive amalgamations of relevant literature.Results The classic symptoms of DBD are decreased bladder sensation,increased bladder capacity,and impaired bladder emptying with resultant elevated post-void residual urine.However,recent clinical and experimental evidence indicate a strong presence of storage problems such as urge incontinence in diabetes.Recent studies of DBD in animal models of type 1 diabetes have revealed temporal effects of diabetes,causing an early phase of compensatory bladder function and a later phase of decompensated bladder function.The pathophysiology of DBD is multifactorial,including disturbances of the detrusor,urothelium,autonomic nerves,and urethra.Polyuria and hyperglycemia play important but distinctive roles in induction of bladder dysfunction in type 1 diabetes.Polyuria causes significant bladder hypertrophy in the early stage of diabetes,whereas oxidative stress in the bladder caused by chronic hyperglycemia may play an important role in the late stage failure of bladder function.Conclusions DBD includes time-dependent and mixed manifestations.The pathological alterations include muscle,nerve,and urothelium.Polyuria and hyperglycemia independently contribute to the pathogenesis of DBD.Treatments for DBD are limited.Future clinical studies on DBD in type 1 and type 2 diabetes should be investigated separately.Animal studies of DBD in type 2 diabetes are needed,from the natural history to mechanisms.Further understanding of the molecular

  15. Scaling of voids and fractality in the galaxy distribution

    CERN Document Server

    Gaite, J; Gaite, Jose; Manrubia, Susanna C.

    2002-01-01

    We study here, from first principles, what properties of voids are to be expected in a fractal point distribution and how the void distribution is related to its morphology. We show this relation in various examples and apply our results to the distribution of galaxies. If the distribution of galaxies forms a fractal set, then this property results in a number of scaling laws to be fulfilled by voids. Consider a fractal set of dimension $D$ and its set of voids. If voids are ordered according to decreasing sizes (largest void has rank R=1, second largest R=2 and so on), then a relation between size $\\Lambda$ and rank of the form $\\Lambda (R) \\propto R^{-z}$ must hold, with $z = d/D$, and where $d$ is the euclidean dimension of the space where the fractal is embedded. The physical restriction $D 1$ in a fractal set. The average size $\\bar \\Lambda$ of voids depends on the upper ($\\Lambda_u$) and the lower ($\\Lambda_l$) cut-off as ${\\bar \\Lambda} \\propto \\Lambda_u^{1-D/d} \\Lambda_l^{D/d}$. Current analysis of v...

  16. Partial discharges within two spherical voids in an epoxy resin

    Science.gov (United States)

    Illias, H. A.; Chen, G.; Bakar, A. H. A.; Mokhlis, H.; Tunio, M. A.

    2013-08-01

    A void in a dielectric insulation material may exist due to imperfection in the insulation manufacturing or long term stressing. Voids have been identified as one of the common sources of partial discharge (PD) activity within an insulation system, such as in cable insulation and power transformers. Therefore, it is important to study PD phenomenon within void cavities in insulation. In this work, a model of PD activity within two spherical voids in a homogeneous dielectric material has been developed using finite element analysis software to study the parameters affecting PD behaviour. The parameters that have been taken into account are the void surface conductivity, electron generation rate and the inception and extinction fields. Measurements of PD activity within two spherical voids in an epoxy resin under ac sinusoidal applied voltage have also been performed. The simulation results have been compared with the measurement data to validate the model and to identify the parameters affecting PD behaviour. Comparison between measurements of PD activity within single and two voids in a dielectric material have also been made to observe the difference of the results under both conditions.

  17. Voiding Chain Cystourethography: Assessing A Historical Test's Role in Selection for Urethrolysis

    Directory of Open Access Journals (Sweden)

    Steven P Petrou

    2013-07-01

    Full Text Available Objective To analyze the benefit of voiding chain cystourethrography (VCC [placing a radiographic opaque chain into the urethra and bladder and asking the patient to void under fluoroscopy] in the urodynamic evaluation of female bladder outlet obstruction (BOO. Materials and Methods Females with post anti-incontinence operation voiding dysfunction who underwent urodynamic evaluation augmented with VCC and later had urethrolysis were identified. Six diagnostic criteria for obstruction were applied to each patient: (1 VCC ( obstructed: chain was angulated and could not be voiding out (2 Video urodynamic study (VUDS (detrusor contraction combined with radiographic obstruction (3 maximum flow (Qmax ≤ 15 cc/sec, detrusor pressure (pDet@ Qmax ≥ 20 cm H20 (4 Qmax ≤ 11 cc/sec, pDet@ Qmax ≥ 25 cm H20 (5 Qmax ≤ 12 cc/sec, pDet@ Qmax ≥ 25 cm H20 (6 Blaivas-Groutz (B-G nomogram. Urethrolysis results were reviewed. Agreement in assessment of BOO criteria was assessed by estimating the proportion of pair-wise agreements along with an exact binomial 95% confidence interval (CI and by estimating kappa along with a 95% CI. Results Twenty-one patients were identified. Twenty of the 22 urethrolyses (91% were clinically successful. Diagnosis of BOO was most common for VCC (86% and then B-G Nomogram (67%. Agreement with the VCC was relatively poor for each of the five other methods (14%-62% with the video urodynamic study (VUDS being the best. Three patients with successful urethrolysis were diagnosed only by the VCC. All of kappa values regarding agreement with the VCC were low; the highest value of 0.15 was observed for VUDS. Conclusion VCC may augment selection criteria for urethrolysis.

  18. Image analysis of aggregate,mastic and air void phases for asphalt mixture%Image analysis of aggregate, mastic and air void phases for asphalt mixture

    Institute of Scientific and Technical Information of China (English)

    ADHIKARI Sanjeev; YOU Zhan-ping; HAO Pei-wen; WANG Hai-nian

    2013-01-01

    The shape characterization and spatial distribution of aggregate,mastic and air void phases for asphalt mixture were analyzed.Three air void percentage asphalt mixtures,4%,7% and 8%,respectively,were cut into cross sections and polished.X-ray scanning microscope was used to capture aggregate,mastic,air void phase by the image.The average of polygon diameter was chosen as a threshold to determine which aggregates would be retained on a given sieve.The aggregate morphological image from scanned image was utilized by digital image processing method to calculate the gradation of aggregate and simulate the real gradation.Analysis result shows that the air void of asphalt mixture has influence on the correlation between calculation gradation and actual gradation.When comparing 4.75 mm sieve size of 4%,7% and 8% air void asphalt mixtures,7% air void asphalt mixture has 55% higher than actual size gradation,8% air void asphalt mixture has 8% higher than actual size gradation,and 4% air void asphalt mixture has 3.71% lower than actual size gradation.4% air void asphalt mixture has the best correlation between calculation gradation and actual gradation comparing to other specimens.The air void percentage of asphalt mixture has no obvious influence on the air void orientation,and three asphalt mixtures show the similar air orientation along the same direction.4 tabs,7 figs,17 refs.

  19. Baryon effects on void statistics in the EAGLE simulation

    CERN Document Server

    Paillas, Enrique; Padilla, Nelson; Tissera, Patricia; Helly, John; Schaller, Matthieu

    2016-01-01

    Cosmic voids are promising tools for cosmological tests due to their sensitivity to dark energy, modified gravity and alternative cosmological scenarios. Most previous studies in the literature of void properties use cosmological N-body simulations of dark matter (DM) particles that ignore the potential effect of baryonic physics. We analyse voids in the mass and subhalo density field in the EAGLE simulations, which follow the evolution of galaxies in a Lambda cold dark matter Universe with state-of-the-art subgrid models for baryonic processes. We study the effect of baryons on void statistics by comparing results with simulations that only follow the evolution of DM, but use the same initial conditions as EAGLE. When using the mass in the simulation, we find that a DM-only simulation produces 24 per cent more voids than a hydrodynamical one, but this difference comes mainly from voids with radii smaller than 5 Mpc. We do not find significant differences in the density profiles between voids in EAGLE and its...

  20. Decay of charge deposited on the wall of gaseous void

    DEFF Research Database (Denmark)

    McAllister, Iain Wilson

    1992-01-01

    After partial discharge activity within a gaseous void, charges accumulate on the wall of the void. The decay of such charges due to surface currents at the void wall is studied analytically, and the factors affecting this decay are indicated. The results show that in terms of the basic time...... constant, the decay can take a considerable amount of time. The decay rate is significantly reduced by an increase in the permittivity of the bulk medium. The dominating influence of this permittivity is likewise reflected in the increased duration and thereby prolonged inhomogeneity of the electric field...

  1. The Void Galaxy Survey: Galaxy Evolution and Gas Accretion in Voids

    NARCIS (Netherlands)

    Kreckel, Kathryn; van Gorkom, Jacqueline H.; Beygu, Burcu; van de Weijgaert, Marinus; van der Hulst, J. M.; Aragon-Calvo, Miguel A.; Peletier, Reynier F.

    2014-01-01

    Voids represent a unique environment for the study of galaxy evolution, as the lower density environment is expected to result in shorter merger histories and slower evolution of galaxies. This provides an ideal opportunity to test theories of galaxy formation and evolution. Imaging of the neutral h

  2. EFFECT OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION ON CEREBRAL HEMODYNAMICS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION (THE RESULTS OF OBSERVATIONAL STUDIES

    Directory of Open Access Journals (Sweden)

    V. E. Kulikov

    2015-12-01

    Full Text Available Aim. To study the effect of left ventricular (LV systolic dysfunction on cerebral hemodynamic in patients with ST segment elevation myocardial infarction (STEMI during acute period. Material and methods. Cerebral hemodynamics ultrasound assessment was performed in the extra-and intracranial vessels in 118 patients with STEMI. Results. Significant changes in cerebral hemodynamics were found in LV systolic dysfunction with ejection fraction (LVEF ≤40% due to hemispheric blood flow asymmetry in the middle cerebral artery (MCA as large as 45.1±6.7% with correlation coefficient r=-0.87. Compensation of cerebral blood flow was manifested in vasoconstriction or vasodilation (resistive index 0.63-0.76 and 0.49-0.43 c.u., respectively. Conclusion. A strong relationship between LV systolic dysfunction and cerebral hemodynamic was found in patients with STEMI. It was manifested in significant contralateral hemispheric blood flow asymmetry in MCA in patients with LVEF ≤40%. Reduction in cerebral blood flow velocity activated autoregulation mechanism in the form of vasoconstriction or vasodilation.

  3. Examining Sexual Dysfunction in Non‐Muscle‐Invasive Bladder Cancer: Results of Cross‐Sectional Mixed‐Methods Research

    Directory of Open Access Journals (Sweden)

    Marc A. Kowalkowski, PhD

    2014-08-01

    Conclusions: Survivors' sexual symptoms may result from NMIBC, comorbidities, or both. These results inform literature and practice by raising awareness about the frequency of symptoms and the impact on NMIBC survivors' intimate relationships. Further work is needed to design symptom management education programs to dispel misinformation about contamination post‐treatment and improve quality of life. Kowalkowski MA, Chandrashekar A, Amiel GE, Lerner SP, Wittmann DA, Latini DM, and Goltz HH. Examining sexual dysfunction in non‐muscle‐invasive bladder cancer: Results of cross‐sectional mixed‐methods research. Sex Med 2014;2:141–151.

  4. CT perfusion technique for assessment of early kidney allograft dysfunction: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Helck, A.; Notohamiprodjo, M.; Schoen, F.; Nikolaou, K.; Clevert, D.A.; Reiser, M.; Becker, C. [Ludwig-Maximilians-University of Munich, Department of Clinical Radiology, University Hospitals Grosshadern, Munich (Germany); Wessely, M.; Schoenermarck, U.; Fischereder, M. [Ludwig-Maximilians-University of Munich, Department of Internal Medicine IV, Nephrology, University Hospitals Grosshadern, Munich (Germany); Klotz, E. [Siemens Healthcare, Computed Tomography, Forchheim (Germany)

    2013-09-15

    To assess the benefit of quantitative computed tomography (CT) perfusion for differentiating acute tubular necrosis (ATN) and acute rejection (AR) in kidney allografts. Twenty-two patients with acute kidney allograft dysfunction caused by either AR (n = 6) or ATN (n = 16) were retrospectively included in the study. All patients initially underwent a multiphase CT angiography (CTA) protocol (12 phases, one phase every 3.5 s) covering the whole graft to exclude acute postoperative complications. Multiphase CT dataset and dedicated software were used to calculate renal blood flow. Renal biopsy or clinical course of disease served as the standard of reference. Mean effective radiation dose and mean amount of contrast media were calculated. Renal blood flow values were significantly lower (P = 0.001) in allografts undergoing AR (48.3 {+-} 21 ml/100 ml/min) compared with those with ATN (77.5 {+-} 21 ml/100 ml/min). No significant difference (P = 0.71) was observed regarding creatinine level with 5.65 {+-} 3.1 mg/dl in AR and 5.3 {+-} 1.9 mg/dl in ATN. The mean effective radiation dose of the CT perfusion protocol was 13.6 {+-} 5.2 mSv; the mean amount of contrast media applied was 34.5 {+-} 5.1 ml. All examinations were performed without complications. CT perfusion of kidney allografts may help to differentiate between ATN and rejection. (orig.)

  5. The Void Galaxy Survey: Galaxy Evolution and Gas Accretion in Voids

    CERN Document Server

    Kreckel, Kathryn; Beygu, Burcu; van de Weygaert, Rien; van der Hulst, J M; Aragon-Calvo, Miguel A; Peletier, Reynier F

    2014-01-01

    Voids represent a unique environment for the study of galaxy evolution, as the lower density environment is expected to result in shorter merger histories and slower evolution of galaxies. This provides an ideal opportunity to test theories of galaxy formation and evolution. Imaging of the neutral hydrogen, central in both driving and regulating star formation, directly traces the gas reservoir and can reveal interactions and signs of cold gas accretion. For a new Void Galaxy Survey (VGS), we have carefully selected a sample of 59 galaxies that reside in the deepest underdensities of geometrically identified voids within the SDSS at distances of ~100 Mpc, and pursued deep UV, optical, Halpha, IR, and HI imaging to study in detail the morphology and kinematics of both the stellar and gaseous components. This sample allows us to not only examine the global statistical properties of void galaxies, but also to explore the details of the dynamical properties. We present an overview of the VGS, and highlight key re...

  6. The Void Galaxy Survey: Morphology and Star Formation Properties of Void Galaxies

    CERN Document Server

    Beygu, B; van der Hulst, J M; Peletier, R; Jarrett, T; van de Weygaert, R; van Gorkom, J H; Aragón-Calvo, M

    2015-01-01

    We present the structural and star formation properties of 59 void galaxies as part of the Void Galaxy Survey (VGS). Our aim is to study in detail the physical properties of these void galaxies and study the effect of the void environment on galaxy properties. We use Spitzer 3.6 $\\rm{\\mu m}$ and B-band imaging to study the morphology and color of the VGS galaxies. For their star formation properties, we use Halpha and GALEX near-UV imaging. We compare our results to a range of galaxies of different morphologies in higher density environments. We find that the VGS galaxies are in general disk dominated and star forming galaxies. Their star formation rates are, however, often less than 1 $\\rm{M_{\\odot}}$ $\\rm{yr^{-1}}$. There are two early-type galaxies in our sample as well. In $\\rm{r_{e}}$ versus $\\rm{M_{B}}$ parameter space, VGS galaxies occupy the same space as dwarf irregulars and spirals.

  7. Role of Caffeine Intake on Erectile Dysfunction in US Men: Results from NHANES 2001-2004.

    Directory of Open Access Journals (Sweden)

    David S Lopez

    Full Text Available Caffeine is consumed by more than 85% of adults and little is known about its role on erectile dysfunction (ED in population-based studies. We investigated the association of caffeine intake and caffeinated beverages with ED, and whether these associations vary among comorbidities for ED.Data were analyzed for 3724 men (≥20 years old who participated in the National Health and Nutrition Examination Survey (NHANES. ED was assessed by a single question during a self-paced, computer-assisted self-interview. We analyzed 24-h dietary recall data to estimate caffeine intake (mg/day. Multivariable logistic regression analyses using appropriate sampling weights were conducted.We found that men in the 3rd (85-170 mg/day and 4th (171-303 mg/day quintiles of caffeine intake were less likely to report ED compared to men in the lowest 1st quintile (0-7 mg/day [OR: 0.58; 95% CI, 0.37-0.89; and OR: 0.61; 95% CI, 0.38-0.97, respectively], but no evidence for a trend. Similarly, among overweight/obese and hypertensive men, there was an inverse association between higher quintiles of caffeine intake and ED compared to men in the lowest 1st quintile, P≤0.05 for each quintile. However, only among men without diabetes we found a similar inverse association (Ptrend = 0.01.Caffeine intake reduced the odds of prevalent ED, especially an intake equivalent to approximately 2-3 daily cups of coffee (170-375 mg/day. This reduction was also observed among overweight/obese and hypertensive, but not among diabetic men. Yet, these associations are warranted to be investigated in prospective studies.

  8. Coupling effects of void size and void shape on the growth of prolate ellipsoidal microvoid

    Institute of Scientific and Technical Information of China (English)

    Minsheng Huang; Zhenhuan Li; Cheng Wang

    2005-01-01

    The combined effects of void size and void shape on the void growth are studied by using the classical spectrum method. An infinite solid containing an isolated prolate spheroidal void is considered to depict the void shape effect and the Fleck-Hutchinson phenomenological strain gradient plasticity theory is employed to capture the size effects. It is found that the combined effects of void size and void shape are mainly controlled by the remote stress triaxiality. Based on this, a new size-dependent void growth model similar to the Rice-Tracey model is proposed and an important conclusion about the size-dependent void growth is drawn: the growth rate of the void with radius smaller than a critical radius rc may be ignored. It is interesting that rc is a material constant independent of the initial void shape and the remote stress triaxiality.

  9. Void formation in ODS EUROFER produced by hot isostatic pressing

    Energy Technology Data Exchange (ETDEWEB)

    Ortega, Y. [Departamento de Fisica, Universidad Carlos III de Madrid, 28911 Leganes (Spain)], E-mail: yanicet@fis.ucm.es; Monge, M.A. [Departamento de Fisica, Universidad Carlos III de Madrid, 28911 Leganes (Spain); Castro, V. de [Department of Materials, University of Oxford, Oxford OX1 3PH (United Kingdom); Munoz, A.; Leguey, T.; Pareja, R. [Departamento de Fisica, Universidad Carlos III de Madrid, 28911 Leganes (Spain)

    2009-04-30

    Positron annihilation experiments were performed on oxide dispersion strengthened (ODS) and non-ODS EUROFER prepared by mechanical alloying and hot isostatic pressing. The results revealed the presence of small voids in these materials in the as-HIPed conditions. Their evolution under isochronal annealing experiments was investigated. The coincidence Doppler broadening spectra of ODS EUROFER exhibited a characteristic signature attributed to positron annihilation in Ar-decorated voids at the oxide particle/matrix interfaces. The variation of the positron annihilation parameters with the annealing temperature showed three stages: up to 623 K, between 823 and 1323 K, and above 1323 K. In the temperature range 823-1323 K void coarsening had effect. Above 1323 K some voids annealed out, but others, associated to oxide particles and small precipitates, survived to annealing at 1523 K. Transmission electron microscopy observations were also performed to verify the characteristics of the surviving defects after annealing at 1523 K.

  10. Effect of Temperature on the Void Growth in Pure Aluminium at High Strain-Rate Loading

    Institute of Scientific and Technical Information of China (English)

    QI Mei-Lan; HE Hong-Liang; YAN Shi-Lin

    2007-01-01

    @@ With the environment temperature varying from 273K to 773K, the dynamic process of void growth in pure aluminium at high strain-rate loading is calculated based on the dynamic growth equation of a void with internal pressure. The result shows that the effect of temperature on the growth of void should be emphasized. Because the initial pressure of void with gas will increase and the viscosity of materials will decrease with the rising of temperature, the growth of void is accelerated. Furthermore, material inertia restrains the growth of void evidently when the diameter exceeds 10μm. The effect of surface tension is very weak in the whole process of void growth.

  11. Size-Effects in Void Growth

    DEFF Research Database (Denmark)

    Niordson, Christian Frithiof

    2005-01-01

    The size-effect on ductile void growth in metals is investigated. The analysis is based on unit cell models both of arrays of cylindrical voids under plane strain deformation, as well as arrays of spherical voids using an axisymmetric model. A recent finite strain generalization of two higher order...

  12. Void Growth in Single and Bicrystalline Metals: Atomistic Calculations

    Science.gov (United States)

    Traiviratana, Sirirat; Bringa, Eduardo M.; Benson, David J.; Meyers, Marc A.

    2007-12-01

    MD simulations in monocrystalline and bicrystalline copper were carried out with LAMMPS to reveal void growth mechanisms. The specimens were subjected to both tensile uniaxial and hydrostatic strains; the results confirm that the emission of (shear) loops is the primary mechanism of void growth. However, these shear loops develop along two slip planes (and not one, as previously thought), in a heretofore unidentified mechanism of cooperative growth. The emission of dislocations from voids is the first stage, and their reaction and interaction is the second stage. These loops, forming initially on different {111} planes, join at the intersection, the Burgers vector of the dislocations being parallel to the intersection of two {111} planes: a direction. Thus, the two dislocations cancel at the intersection and a biplanar shear loop is formed. The expansion of the loops and their cross slip leads to the severely work hardened layer surrounding a growing void. Calculations were carried out on voids with different sizes, and a size dependence of the stress response to emitted dislocations was observed, in disagreement with the Gurson model[1] which is scale independent. Calculations were also carried out for a void at the interface between two grains.

  13. Low and High Surface Brightness Galaxies at Void Walls

    CERN Document Server

    Ceccarelli, L; Lambas, D G; Galaz, G; Padilla, N D

    2012-01-01

    We study the relative fraction of low and high surface brightness galaxies (LSBGs and HSBGs) at void walls in the SDSS DR7. We focus on galaxies in equal local density environments. We assume that the host dark-matter halo mass (for which we use SDSS group masses) is a good indicator of local density. This analysis allows to examine the behavior of the abundance of LSBG and HSBG galaxies at a fixed local density and distinguish the large-scale environment defined by the void geometry. We compare galaxies in the field, and in the void walls; the latter are defined as the volume of void shells of radius equal to that of the void. We find a significant decrement, a factor $\\sim 4$, of the relative fraction of blue, active star-forming LSBGs in equal mass groups at the void walls and the field. This decrement is consistent with an increase of the fraction of blue, active star-forming HSBGs. By contrast, red LSBGs and HSBGs show negligible changes. We argue that these results are consistent with a scenario where L...

  14. ACK filling void first algorithm and performance for asynchronous OPS

    Science.gov (United States)

    Liu, Huanlin; Shi, Yonghe; Chen, Qianbin; Pan, Yingjun

    2007-11-01

    OPS with feedback shared FDL buffer produce large voids due to FDL buffers only supplying discrete step delay and causing FDL queue virtually occupation. By analyzing the TCP traffic and ACK packets feature, the ACK packet void filling first scheduling is presented to decrease packet loss rate and to reduce the FDL voids. When the FDL buffer void size is fit for the ACK packet, the ACK packet is scheduled to FDL immediately. An ACK and non-ACK packets difference and process flow is designed according the TCP packet frame structure. Compared with the conventional FIFO scheduling and smallest FDL void first scheduling, the algorithm reduces greatly the number of ACK occupying the FDL buffer and eliminates large numbers of ACK's bad influence on efficiency of IP data transmission under different FDL buffer depth and traffic load. The results of simulation show that the proposed scheduling makes use of ACK packets first void filling scheduling mechanism to reduce FDL excess load, increases output utilization and reduce packet loss ratio for asynchronous optical network. This approach is shown to minimize the FDL numbers with the feature of high stabilization and photonic integration and to improve real time TCP traffic performance for Internet network.

  15. Redshift-space distortions around voids

    Science.gov (United States)

    Cai, Yan-Chuan; Taylor, Andy; Peacock, John A.; Padilla, Nelson

    2016-11-01

    We have derived estimators for the linear growth rate of density fluctuations using the cross-correlation function (CCF) of voids and haloes in redshift space. In linear theory, this CCF contains only monopole and quadrupole terms. At scales greater than the void radius, linear theory is a good match to voids traced out by haloes; small-scale random velocities are unimportant at these radii, only tending to cause small and often negligible elongation of the CCF near its origin. By extracting the monopole and quadrupole from the CCF, we measure the linear growth rate without prior knowledge of the void profile or velocity dispersion. We recover the linear growth parameter β to 9 per cent precision from an effective volume of 3( h-1Gpc)3 using voids with radius >25 h-1Mpc. Smaller voids are predominantly sub-voids, which may be more sensitive to the random velocity dispersion; they introduce noise and do not help to improve measurements. Adding velocity dispersion as a free parameter allows us to use information at radii as small as half of the void radius. The precision on β is reduced to 5 per cent. Voids show diverse shapes in redshift space, and can appear either elongated or flattened along the line of sight. This can be explained by the competing amplitudes of the local density contrast, plus the radial velocity profile and its gradient. The distortion pattern is therefore determined solely by the void profile and is different for void-in-cloud and void-in-void. This diversity of redshift-space void morphology complicates measurements of the Alcock-Paczynski effect using voids.

  16. The life and death of cosmic voids

    CERN Document Server

    Sutter, P M; Falck, Bridget; Onions, Julian; Hamaus, Nico; Knebe, Alexander; Srisawat, Chaichalit; Schneider, Aurel

    2014-01-01

    We investigate the formation, growth, merger history, movement, and destruction of cosmic voids detected via the watershed transform in a cosmological N-body dark matter {\\Lambda}CDM simulation. By adapting a method used to construct halo merger trees, we are able to trace individual voids back to their initial appearance and record the merging and evolution of their progenitors at high redshift. For the scales of void sizes captured in our simulation, we find that the void formation rate peaks at scale factor 0.3, which coincides with a growth in the void hierarchy and the emergence of dark energy. Voids of all sizes appear at all scale factors, though the median initial void size decreases with time. When voids become detectable they have nearly their present-day volumes. Almost all voids have relatively stable growth rates and suffer only infrequent minor mergers. Dissolution of a void via merging is very rare. Instead, most voids maintain their distinct identity as annexed subvoids of a larger parent. The...

  17. Irradiation creep relaxation of void swelling-driven stresses

    Energy Technology Data Exchange (ETDEWEB)

    Hall, M.M., E-mail: hallmm63@comcast.net [MacRay Consulting, 1366 Hillsdale Drive, Monroeville, PA (United States)

    2013-01-15

    Highlights: Black-Right-Pointing-Pointer Irradiation void swelling can cause distortion of reactor core components. Black-Right-Pointing-Pointer Constrained swelling can drive stresses beyond acceptable levels. Black-Right-Pointing-Pointer Compressive stresses decrease irradiation swelling rates. Black-Right-Pointing-Pointer Irradiation creep relaxes swelling-driven stresses and core restraint forces. Black-Right-Pointing-Pointer Swelling-driven creep stresses are consistent with predictions of a proposed model. - Abstract: Swelling-driven-creep test specimens are used to measure the compressive stresses that develop due to constraint of irradiation void swelling. These specimens use a previously non-irradiated 20% CW Type 316 stainless steel holder to axially restrain two Type 304 stainless steel tubular specimens that were previously irradiated in the US Experimental Breeder Reactor (EBR-II) at 490 Degree-Sign C. One specimen was previously irradiated to fluence levels in the void nucleation regime (9 dpa) and the other in the quasi-steady void growth regime (28 dpa). A lift-off compliance measurement technique was used post-irradiation to determine compressive stresses developed during reirradiation of the two specimen assemblies in Row 7 of EBR-II at temperatures of 547 Degree-Sign C and 504 Degree-Sign C, respectively, to additional damage levels each of about 5 dpa. Results obtained on the higher fluence swelling-driven-creep specimen show that compressive stress due to constraint of swelling retards void swelling to a degree that is consistent with active load uniaxial compression specimens that were irradiated as part of a previously reported multiaxial in-reactor creep experiment. Swelling results obtained on the lower fluence swelling-driven creep specimen show a much larger effect of compressive stress in reducing swelling, demonstrating that the larger effect of stress on swelling is on void nucleation as compared to void growth. Test results are

  18. Systemic atherosclerosis and voiding symptom.

    Science.gov (United States)

    Yeniel, A Ozgur; Ergenoglu, A Mete; Meseri, Reci; Ari, Anıl; Sancar, Ceren; Itil, Ismail Mete

    2017-03-01

    To evaluate the effect of atherosclerosis on the storage and voiding symptoms of the bladder in women with overactive bladder (OAB). We retrospectively reviewed the charts of women with OAB who were evaluated between 2013 and 2015 in our urogynecology unit. Charts were assessed for history, examination findings, urinary diary, quality of life (QOL) questionnaires, urodynamic studies (UDSs), and four main risk factors for atherosclerosis: hypertension, diabetes mellitus, smoking, and hyperlipidemia. In a previous study, these were defined as vascular risk factors. Cases were excluded for insufficient data, diabetes mellitus with dysregulated blood glucose, or prolapse greater than 1cm to avoid confusing bladder outlet obstruction. We included 167 eligible cases in this study. We evaluated storage and voiding symptoms such as frequency, nocturia, residual urine volume, and voiding difficulties and UDS findings such as maximum bladder capacity, first desire, strong desire, detrusor overactivity, and bladder contractility index. The vascular risk score was categorized as "no risk" if the woman did not have any of the four risk factors and "at risk" if she had any of the factors. Independent sample t-test and chi-square tests were performed for analyses. Among the participants (n=167), 71.9% had at least one vascular risk factor. Those who were at risk were facing significantly more wet-type OAB (p=0.003) and nocturia (p=0.023). Moreover, mean age (p=0.008) and mean gravidity (p=0.020) were significantly higher in the at-risk group, whereas mean total nocturia QOL questionnaire scores (p=0.029) were significantly lower. Our findings suggest that aging and atherosclerosis may be associated with severe OAB and poorer QOL. Nocturia and related parameters of poor quality can be explained by impaired bladder neck perfusion. Future trials need to assess vascular and molecular changes in women with OAB. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. Void fraction prediction in saturated flow boiling

    Energy Technology Data Exchange (ETDEWEB)

    Francisco J Collado [Dpto de Ingenieria Mecanica-Motores Termicos, CPS-B, Universidad de Zaragoza, Maria de Luna 50018-Zaragoza (Spain)

    2005-07-01

    vertical and horizontal saturated flow boiling at several pressures of industrial interest. The first result is that the measured specific linear heat is not at all equal to the mixture enthalpy gradient based on the true quality, the difference being a factor quite close to the classic value of the slip ratio, suggesting that this parameter should be included in the thermodynamic heat balance. Furthermore it has been possible to predict this slip factor from the process parameters namely, inlet pressure and velocity, and heat flux. Hence allowing the accurate prediction of the true mass quality from the modified heat balance and so, from classic thermodynamic relationships, to derive accurate values of the void fraction that compares quite well with the measured ones in the Cambridge project. (author)

  20. Statistical geometry of lattice chain polymers with voids of defined shapes: Sampling with strong constraints

    Science.gov (United States)

    Lin, Ming; Chen, Rong; Liang, Jie

    2008-02-01

    Proteins contain many voids, which are unfilled spaces enclosed in the interior. A few of them have shapes compatible to ligands and substrates and are important for protein functions. An important general question is how the need for maintaining functional voids is influenced by, and affects other aspects of proteins structures and properties (e.g., protein folding stability, kinetic accessibility, and evolution selection pressure). In this paper, we examine in detail the effects of maintaining voids of different shapes and sizes using two-dimensional lattice models. We study the propensity for conformations to form a void of specific shape, which is related to the entropic cost of void maintenance. We also study the location that voids of a specific shape and size tend to form, and the influence of compactness on the formation of such voids. As enumeration is infeasible for long chain polymer, a key development in this work is the design of a novel sequential Monte Carlo strategy for generating large number of sample conformations under very constraining restrictions. Our method is validated by comparing results obtained from sampling and from enumeration for short polymer chains. We succeeded in accurate estimation of entropic cost of void maintenance, with and without an increasing number of restrictive conditions, such as loops forming the wall of void with fixed length, with additionally fixed starting position in the sequence. Additionally, we have identified the key structural properties of voids that are important in determining the entropic cost of void formation. We have further developed a parametric model to predict quantitatively void entropy. Our model is highly effective, and these results indicate that voids representing functional sites can be used as an improved model for studying the evolution of protein functions and how protein function relates to protein stability.

  1. The dark matter of galaxy voids

    CERN Document Server

    Sutter, P M; Wandelt, Benjamin D; Weinberg, David H; Warren, Michael S

    2013-01-01

    How do observed voids relate to the underlying dark matter distribution? To examine the spatial distribution of dark matter contained within voids identified in galaxy surveys, we apply Halo Occupation Distribution models representing sparsely and densely sampled galaxy surveys to a high-resolution N-body simulation. We compare these galaxy voids to voids found in the halo distribution, low-resolution dark matter, and high-resolution dark matter. We find that voids at all scales in densely sampled surveys - and medium- to large-scale voids in sparse surveys - trace the same underdensities as dark matter, but they are larger in radius by ~20%, they have somewhat shallower density profiles, and they have centers offset by ~0.4Rv rms. However, in void-to-void comparison we find that shape estimators are less robust to sampling, and the largest voids in sparsely sampled surveys suffer fragmentation at their edges. We find that voids in galaxy surveys always correspond to underdensities in the dark matter, though ...

  2. The dark matter of galaxy voids

    Science.gov (United States)

    Sutter, P. M.; Lavaux, Guilhem; Wandelt, Benjamin D.; Weinberg, David H.; Warren, Michael S.

    2014-03-01

    How do observed voids relate to the underlying dark matter distribution? To examine the spatial distribution of dark matter contained within voids identified in galaxy surveys, we apply Halo Occupation Distribution models representing sparsely and densely sampled galaxy surveys to a high-resolution N-body simulation. We compare these galaxy voids to voids found in the halo distribution, low-resolution dark matter and high-resolution dark matter. We find that voids at all scales in densely sampled surveys - and medium- to large-scale voids in sparse surveys - trace the same underdensities as dark matter, but they are larger in radius by ˜20 per cent, they have somewhat shallower density profiles and they have centres offset by ˜ 0.4Rv rms. However, in void-to-void comparison we find that shape estimators are less robust to sampling, and the largest voids in sparsely sampled surveys suffer fragmentation at their edges. We find that voids in galaxy surveys always correspond to underdensities in the dark matter, though the centres may be offset. When this offset is taken into account, we recover almost identical radial density profiles between galaxies and dark matter. All mock catalogues used in this work are available at http://www.cosmicvoids.net.

  3. Neurexin Dysfunction in Adult Neurons Results in Autistic-like Behavior in Mice

    Directory of Open Access Journals (Sweden)

    Luis G. Rabaneda

    2014-07-01

    Full Text Available Autism spectrum disorders (ASDs comprise a group of clinical phenotypes characterized by repetitive behavior and social and communication deficits. Autism is generally viewed as a neurodevelopmental disorder where insults during embryonic or early postnatal periods result in aberrant wiring and function of neuronal circuits. Neurexins are synaptic proteins associated with autism. Here, we generated transgenic βNrx1ΔC mice in which neurexin function is selectively impaired during late postnatal stages. Whole-cell recordings in cortical neurons show an impairment of glutamatergic synaptic transmission in the βNrx1ΔC mice. Importantly, mutant mice exhibit autism-related symptoms, such as increased self-grooming, deficits in social interactions, and altered interaction for nonsocial olfactory cues. The autistic-like phenotype of βNrx1ΔC mice can be reversed after removing the mutant protein in aged animals. The defects resulting from disruption of neurexin function after the completion of embryonic and early postnatal development suggest that functional impairment of mature circuits can trigger autism-related phenotypes.

  4. Testing the imprint of nonstandard cosmologies on void profiles using Monte Carlo random walks

    Science.gov (United States)

    Achitouv, Ixandra

    2016-11-01

    Using Monte Carlo random walks of a log-normal distribution, we show how to qualitatively study void properties for nonstandard cosmologies. We apply this method to an f (R ) modified gravity model and recover the N -body simulation results of [1 I. Achitouv, M. Baldi, E. Puchwein, and J. Weller, Phys. Rev. D 93, 103522 (2016).] for the void profiles and their deviation from GR. This method can potentially be extended to study other properties of the large scale structures such as the abundance of voids or overdense environments. We also introduce a new way to identify voids in the cosmic web, using only a few measurements of the density fluctuations around random positions. This algorithm allows us to select voids with specific profiles and radii. As a consequence, we can target classes of voids with higher differences between f (R ) and standard gravity void profiles. Finally, we apply our void criteria to galaxy mock catalogues and discuss how the flexibility of our void finder can be used to reduce systematic errors when probing the growth rate in the galaxy-void correlation function.

  5. Testing the imprint of non-standard cosmologies on void profiles using Monte Carlo random walks

    CERN Document Server

    Achitouv, Ixandra

    2016-01-01

    Using a Monte Carlo random walks of a log-normal distribution, we show how to qualitatively study void properties for non-standard cosmologies. We apply this method to an f(R) modified gravity model and recover the N-body simulation results of (Achitouv et al. 2016) for the void profiles and their deviation from GR. This method can potentially be extended to study other properties of the large scale structures such as the abundance of voids or overdense environments. We also introduce a new way to identify voids in the cosmic web, using only a few measurements of the density fluctuations around random positions. This algorithm allows to select voids with specific profiles and radii. As a consequence, we can target classes of voids with higher differences between f(R) and standard gravity void profiles. Finally we apply our void criteria to galaxy mock catalogues and discuss how the flexibility of our void finder can be used to reduce systematics errors when probing the growth rate in the galaxy-void correlati...

  6. Nanovoid growth in BCC α-Fe: influences of initial void geometry

    Science.gov (United States)

    Xu, Shuozhi; Su, Yanqing

    2016-12-01

    The growth of voids has a great impact on the mechanical properties of ductile materials by altering their microstructures. Exploring the process of void growth at the nanoscale helps in understanding the dynamic fracture of metals. While some very recent studies looked into the effects of the initial geometry of an elliptic void on the plastic deformation of face-centered cubic metals, a systematic study of the initial void ellipticity and orientation angle in body-centered cubic (BCC) metals is still lacking. In this paper, large scale molecular dynamics simulations with millions of atoms are conducted, investigating the void growth process during tensile loading of metallic thin films in BCC α-Fe. Our simulations elucidate the intertwined influences on void growth of the initial ellipticity and initial orientation angle of the void. It is shown that these two geometric parameters play an important role in the stress-strain response, the nucleation and evolution of defects, as well as the void size/outline evolution in α-Fe thin films. Results suggest that, together with void size, different initial void geometries should be taken into account if a continuum model is to be applied to nanoscale damage progression.

  7. The Aspen--Amsterdam Void Finder Comparison Project

    CERN Document Server

    Colberg, Joerg M; Foster, Caroline; Platen, Erwin; Brunino, Riccardo; Neyrinck, Mark; Basilakos, Spyros; Fairall, Anthony; Feldman, Hume; Gottloeber, Stefan; Hahn, Oliver; Hoyle, Fiona; Mueller, Volker; Nelson, Lorne; Plionis, Manolis; Porciaini, Cristiano; Shandarin, Sergei; Vogeley, Michael S; van de Weygaert, Rien

    2008-01-01

    Despite a history that dates back at least a quarter of a century studies of voids in the large--scale structure of the Universe are bedevilled by a major problem: there exist a large number of quite different void--finding algorithms, a fact that has so far got in the way of groups comparing their results without worrying about whether such a comparison in fact makes sense. Because of the recent increased interest in voids, both in very large galaxy surveys and in detailed simulations of cosmic structure formation, this situation is very unfortunate. We here present the first systematic comparison study of thirteen different void finders constructed using particles, haloes, and semi--analytical model galaxies extracted from a subvolume of the Millennium simulation. The study includes many groups that have studied voids over the past decade. We show their results and discuss their differences and agreements. As it turns out, the basic results of the various methods agree very well with each other in that they...

  8. The Beckoning Void in Moravagine

    Directory of Open Access Journals (Sweden)

    Stephen K. Bellstrom

    1979-01-01

    Full Text Available The Chapter «Mascha,» lying at the heart of Cendrars's Moravagine , contains within it a variety of images and themes suggestive of emptiness. The philosophy of nihilism is exemplified in the motivations and actions of the group of terrorists seeking to plunge Russia into revolutionary chaos. Mascha's anatomical orifice, symbolizing both a biological and a psychological fault, and the abortion of her child, paralleled by the abortion of the revolutionary ideal among her comrades, are also emblematic of the chapter's central void. Moreover, Cendrars builds the theme of hollowness by describing Moravagine with images of omission, such as «empan» (space or span, «absent,» and «étranger.» Moravagine's presence, in fact, characteristically causes an undercurrent of doubt and uncertainty about the nature of reality to become overt. It is this parodoxical presence which seems to cause the narrator (and consequently the narrative to «lose» a day at the most critical moment of the story. By plunging the reader into the narrator's lapsus memoriae , Cendrars aims at creating a feeling of the kind of mental and cosmic disorder for which Moravagine is the strategist and apologist. This technique of insufficiency is an active technique, even though it relies on the passive idea of removing explanation and connecting details. The reader is invited, or lured, into the central void of the novel and, faced with unresolvable dilemmas, becomes involved in the same disorder that was initially produced.

  9. Molecular dynamics study of void effect on nanoimprint of single crystal aluminum

    Energy Technology Data Exchange (ETDEWEB)

    Yuan Ying [Center for Precision Engineering, Harbin Institute of Technology, Harbin (China); Sun Tao, E-mail: spm@hit.edu.cn [Center for Precision Engineering, Harbin Institute of Technology, Harbin (China); Zhang Junjie; Yan Yongda [Center for Precision Engineering, Harbin Institute of Technology, Harbin (China)

    2011-06-01

    Pre-existing defects can alter mechanical behavior of materials significantly under applied load. In current study molecular dynamics (MD) simulations are performed to reveal pre-existing void effect on nanoimprint of single crystal Al thin films, such as deformation mechanism and spring back phenomenon. Current simulation results show void acts as strong barrier to dislocation motion, although plastic deformation is dominantly controlled by dislocation activities. It indicates the void volume fraction has strong influence on nanoimprint: the larger the void volume fraction, the smaller the maximum force required for initial dislocation nucleation, and the stronger the interaction between extended dislocation and void. It also demonstrates that there is a critical void volume fraction for minimum spring back, which is resulted from competition between two roles affecting dislocation annihilation.

  10. Influence of void ratio on phase change of thermal energy storage for heat pipe receiver

    Directory of Open Access Journals (Sweden)

    Xiaohong Gui

    2015-01-01

    Full Text Available In this paper, influence of void ratio on phase change of thermal storage unit for heat pipe receiver under microgravity is numerically simulated. Accordingly, mathematical model is set up. A solidification-melting model upon the enthalpy-porosity method is specially provided to deal with phase changes. The liquid fraction distribution of thermal storage unit of heat pipe receiver is shown. The fluctuation of melting ratio in PCM canister is indicated. Numerical results are compared with experimental ones in Japan. The results show that void cavity prevents the process of phase change greatly. PCM melts slowly during sunlight periods and freezes slowly during eclipse periods as void ratio increases. The utility ratio of PCM during both sunlight periods and eclipse periods decreases obviously with the improvement of void ratio. The thermal resistance of void cavity is much higher than that of PCM canister wall. Void cavity prevents the heat transfer between PCM zone and canister wall.

  11. Voiding generation in copper interconnect under room temperature storage in 12 years

    Science.gov (United States)

    Matsuyama, Hideya; Suzuki, Takashi; Nakamura, Tomoji; Shiozu, Motoki; Ehara, Hideo; Oshima, Masao; Soeda, Takeshi; Hosoi, Hirokazu; Yamabe, Kikuo

    2017-07-01

    We measured the internal residual stress change of ULSI copper interconnects at room temperature for 12 years to confirm the stress migration phenomenon. The residual stress decreased and voids were generated. Furthermore, we investigated the stress change results and void features obtained through physical analyses. The voids had the same features as those in the high-temperature storage. The estimated volume shrinkage agreed with the total volume of the observed voids, suggesting that void generation causes the decrease in stress. From the obtained result, we conclude that the stress migration degradation phenomenon occurs even at room temperature in the long-term storage, and that the void feature is almost identical to that in the high-temperature acceleration test.

  12. The Influence of the Presence of Multiple Voids on the Discharge Patterns in Solid Epoxy Insulation

    DEFF Research Database (Denmark)

    Holbøll, Joachim T.; Henriksen, Mogens; Larsen, Esben

    1996-01-01

    In this paper, partial discharge test results from initial long term testing on samples which contain more voids, when exposed to a high electric stress will be presented. The influence on the discharge patterns, phase- and height-analyses, of such parameter as the number of voids and the void di...... diameters will be given. A first evaluation/opinion of the impact this could have on the estimation of the insulation condition of electrical equipment, based on the identification of PD-patterns, will also be given.......In this paper, partial discharge test results from initial long term testing on samples which contain more voids, when exposed to a high electric stress will be presented. The influence on the discharge patterns, phase- and height-analyses, of such parameter as the number of voids and the void...

  13. Universal density profile for cosmic voids.

    Science.gov (United States)

    Hamaus, Nico; Sutter, P M; Wandelt, Benjamin D

    2014-06-27

    We present a simple empirical function for the average density profile of cosmic voids, identified via the watershed technique in ΛCDM N-body simulations. This function is universal across void size and redshift, accurately describing a large radial range of scales around void centers with only two free parameters. In analogy to halo density profiles, these parameters describe the scale radius and the central density of voids. While we initially start with a more general four-parameter model, we find two of its parameters to be redundant, as they follow linear trends with the scale radius in two distinct regimes of the void sample, separated by its compensation scale. Assuming linear theory, we derive an analytic formula for the velocity profile of voids and find an excellent agreement with the numerical data as well. In our companion paper [Sutter et al., arXiv:1309.5087 [Mon. Not. R. Astron. Soc. (to be published)

  14. Void Profile from Planck Lensing Potential Map

    Science.gov (United States)

    Chantavat, Teeraparb; Sawangwit, Utane; Wandelt, Benjamin D.

    2017-02-01

    We use the lensing potential map from Planck CMB lensing reconstruction analysis and the “Public Cosmic Void Catalog” to measure the stacked void lensing potential. We have made an attempt to fit the HSW void profile parameters from the stacked lensing potential. In this profile, four parameters are needed to describe the shape of voids with different characteristic radii R V . However, we have found that after reducing the background noise by subtracting the average background, there is a residue lensing power left in the data. The inclusion of the environment shifting parameter, {γ }V, is necessary to get a better fit to the data with the residue lensing power. We divide the voids into two redshift bins: cmass1 (0.45Digital Sky Survey voids reside in an underdense region.

  15. Cosmology with void-galaxy correlations.

    Science.gov (United States)

    Hamaus, Nico; Wandelt, Benjamin D; Sutter, P M; Lavaux, Guilhem; Warren, Michael S

    2014-01-31

    Galaxy bias, the unknown relationship between the clustering of galaxies and the underlying dark matter density field is a major hurdle for cosmological inference from large-scale structure. While traditional analyses focus on the absolute clustering amplitude of high-density regions mapped out by galaxy surveys, we propose a relative measurement that compares those to the underdense regions, cosmic voids. On the basis of realistic mock catalogs we demonstrate that cross correlating galaxies and voids opens up the possibility to calibrate galaxy bias and to define a static ruler thanks to the observable geometric nature of voids. We illustrate how the clustering of voids is related to mass compensation and show that volume-exclusion significantly reduces the degree of stochasticity in their spatial distribution. Extracting the spherically averaged distribution of galaxies inside voids from their cross correlations reveals a remarkable concordance with the mass-density profile of voids.

  16. Experimental study of 5-hydroxytryptamine 1A receptor agonist to improve the voiding dysfunction in diabetic rats%5-羟色胺1A受体激动剂改善糖尿病大鼠排尿功能障碍的实验研究

    Institute of Scientific and Technical Information of China (English)

    陈加生; 吴刚; 谷宝军

    2014-01-01

    drug administration.A PE-90 catheter was inserted into the bladder,with the other end connected to a syringe pump for continuous infusion of saline and a pressure transducer for intravesical pressure monitor.Dose-response curves for 8-OH-DPAT were followed by WAY-100635 test.The capacity,residual volume,micturition volume,and EUS-EMG were measured.Results Compared to normal control,DM rats had a higher bladder capacity,residual volume,and a lower voiding efficiency.With increasing dose of 8-OH-DPAT (0.003-1.000 mg/kg,i.v.),the micturition volume increased from (2.15±0.49) ml to (2.85±0.21) ml,the residual volume decreased from (3.40±0.74)ml to (1.82±0.48) ml and voiding efficiency changed from (39.0±9.3)% to (61.6±6.9)%.Control rats showed little change in cystometic variable.During the micturition,there was a dose-dependent increased phasic EUS activity correlated with the improved voiding efficiency.WAY-100635 (0.300 mg/kg,i.v.) reversed the 8-OH-DPAT-induced changes.Conclusions Both the bladder voiding efficiency and the periodic EUS activity decrease in DM rats.5-HT1A receptor agonist could promote periodic EUS activity and improve voiding efficiency.

  17. An analytical model for porous single crystals with ellipsoidal voids

    Science.gov (United States)

    Mbiakop, A.; Constantinescu, A.; Danas, K.

    2015-11-01

    A rate-(in)dependent constitutive model for porous single crystals with arbitrary crystal anisotropy (e.g., FCC, BCC, HCP, etc.) containing general ellipsoidal voids is developed. The proposed model, denoted as modified variational model (MVAR), is based on the nonlinear variational homogenization method, which makes use of a linear comparison porous material to estimate the response of the nonlinear porous single crystal. Periodic multi-void finite element simulations are used in order to validate the MVAR for a large number of parameters including cubic (FCC, BCC) and hexagonal (HCP) crystal anisotropy, various creep exponents (i.e., nonlinearity), several stress triaxiality ratios, general void shapes and orientations and various porosity levels. The MVAR model, which involves a priori no calibration parameters, is found to be in good agreement with the finite element results for all cases considered in the rate-dependent context. The model is then used in a predictive manner to investigate the complex response of porous single crystals in several cases with strong coupling between the anisotropy of the crystal and the (morphological) anisotropy induced by the shape and orientation of the voids. Finally, a simple way of calibrating the MVAR with just two adjustable parameters is depicted in the rate-independent context so that an excellent agreement with the FE simulation results is obtained. In this last case, this proposed model can be thought as a generalization of the Gurson model in the context of porous single crystals and general ellipsoidal void shapes and orientations.

  18. Voids in cosmological simulations over cosmic time

    Science.gov (United States)

    Wojtak, Radosław; Powell, Devon; Abel, Tom

    2016-06-01

    We study evolution of voids in cosmological simulations using a new method for tracing voids over cosmic time. The method is based on tracking watershed basins (contiguous regions around density minima) of well-developed voids at low redshift, on a regular grid of density field. It enables us to construct a robust and continuous mapping between voids at different redshifts, from initial conditions to the present time. We discuss how the new approach eliminates strong spurious effects of numerical origin when voids' evolution is traced by matching voids between successive snapshots (by analogy to halo merger trees). We apply the new method to a cosmological simulation of a standard Λ-cold-dark-matter cosmological model and study evolution of basic properties of typical voids (with effective radii 6 h-1 Mpc < Rv < 20 h-1 Mpc at redshift z = 0) such as volumes, shapes, matter density distributions and relative alignments. The final voids at low redshifts appear to retain a significant part of the configuration acquired in initial conditions. Shapes of voids evolve in a collective way which barely modifies the overall distribution of the axial ratios. The evolution appears to have a weak impact on mutual alignments of voids implying that the present state is in large part set up by the primordial density field. We present evolution of dark matter density profiles computed on isodensity surfaces which comply with the actual shapes of voids. Unlike spherical density profiles, this approach enables us to demonstrate development of theoretically predicted bucket-like shape of the final density profiles indicating a wide flat core and a sharp transition to high-density void walls.

  19. Prevalence and independent risk factors for erectile dysfunction in Spain: results of the Epidemiologia de la Disfuncion Erectil Masculina Study.

    Science.gov (United States)

    Martin-Morales, A; Sanchez-Cruz, J J; Saenz de Tejada, I; Rodriguez-Vela, L; Jimenez-Cruz, J F; Burgos-Rodriguez, R

    2001-08-01

    We determined the prevalence of and risks factors for erectile dysfunction in Spain in a cross-sectional study. A total of 2,476 noninstitutionalized Spanish men 25 to 70 years old were interviewed at home and answered a self-administered questionnaire of 71 items, including 2 instruments to define erectile dysfunction, a simple self-assessment question to estimate erectile function and the International Index of Erectile Function. Data on disease, medication and toxic habits were also obtained. With an overall participation rate of 75% the prevalence of erectile dysfunction according to the simple question was 12.1%. According to the erectile function domain of the International Index of Erectile Function the overall prevalence was 18.9%. Several independent risk factors were significantly associated with the probability of erectile dysfunction. Some differences arose according to the tool used to define the condition. However, there was a strong relationship of patient age with frequency or severity no matter which instrument was used to define erectile dysfunction. Diabetes (age adjusted odds ratio 4), high blood pressure (odds ratio 1.58), high cholesterol (1.63), peripheral vascular disorder (2.63), lung disease (3.11), prostate disease (2.93), cardiac problems (1.79), rheumatism (2.37) and allergy (3.08) were significantly associated with erectile dysfunction. Drug intake, which respondents called medication for nerves and sleeping pills, correlated strongly (odds ratio 2.78 and 4.27, respectively), as did tobacco use (2.5) and alcohol consumption (1.53). This study provides data on the prevalence of and risks factors for erectile dysfunction in Spain. The relationship of erectile dysfunction with certain risk factors, such as cardiovascular risk factors and drugs intake, are well known and our study corroborates these associations. Other associations with erectile dysfunction, such as prostate disease, allergy and rheumatism, support findings in previous

  20. Conversion of stacking fault tetrahedra to voids in electron irradiated Fe-Cr-Ni

    Science.gov (United States)

    Kojima, S.; Sano, Y.; Yoshiie, T.; Yoshida, N.; Kiritani, M.

    1986-11-01

    Electron irradiations of the austenitic Fe-13Cr-14Ni alloy were performed with a high voltage electron microscope at temperatures between room temperature and 650 K. Formation of stacking fault tetrahedra, voids and dislocation loops was observed as vacancy clusters. At the lower temperatures, the dominant vacancy clusters were tetrahedra and at the higher temperatures, voids were dominant. In the temperature range at which both tetrahedra and voids were coexistent, conversion of tetrahedra to voids were observed. These results are interpreted as the preferable nucleation of voids at the site of tetrahedra. Local effects of dilatation field at the corner of tetrahedra and the segregation of solute atoms are considered to enhance the nucleation. Clustered defects which are considered to be stacking fault tetrahedra that are formed with D-T fusion neutrons in SUS 316 stainless steel are suggested as the preferable site for void nucleation.

  1. Structure-dependent behavior of stress-induced voiding in Cu interconnects

    Energy Technology Data Exchange (ETDEWEB)

    Wu Zhenyu, E-mail: wuzhenyu@xidian.edu.c [Key Laboratory of Ministry of Education for Band-Gap Semiconductor Materials and Devices, School of Microelectronics, Xidian University, Xi' an 710071 (China); Yang Yintang; Chai Changchun; Li Yuejin; Wang Jiayou; Li Bin; Liu Jing [Key Laboratory of Ministry of Education for Band-Gap Semiconductor Materials and Devices, School of Microelectronics, Xidian University, Xi' an 710071 (China)

    2010-05-03

    Stress modeling and cross-section failure analysis by focused-ion-beam have been used to investigate stress-induced voiding phenomena in Cu interconnects. The voiding mechanism and the effect of the interconnect structure on the stress migration have been studied. The results show that the most concentrated tensile stress appears and voids form at corners of vias on top surfaces of Cu M1 lines. A simple model of stress induced voiding in which vacancies arise due to the increase of the chemical potential under tensile stress and diffuse under the force of stress gradient along the main diffusing path indicates that stress gradient rather than stress itself determines the voiding rate. Cu interconnects with larger vias show less resistance to stress-induced voiding due to larger stress gradient at corners of vias.

  2. Shock-induced hotspot formation and chemical reaction initiation in PETN containing a spherical void

    Science.gov (United States)

    Shan, Tzu-Ray; Thompson, Aidan P.

    2014-05-01

    We present results of reactive molecular dynamics simulations of hotspot formation and chemical reaction initiation in shock-induced compression of pentaerythritol tetranitrate (PETN) with the ReaxFF reactive force field. A supported shockwave is driven through a PETN crystal containing a 20 nm spherical void at a sub-threshold impact velocity of 2 km/s. Formation of a hotspot due to shock-induced void collapse is observed. During void collapse, NO2 is the dominant species ejected from the upstream void surface. Once the ejecta collide with the downstream void surface and the hotspot develops, formation of final products such as N2 and H2O is observed. The simulation provides a detailed picture of how void collapse and hotspot formation leads to initiation at sub-threshold impact velocities.

  3. Electromigration of intergranular voids in metal films for microelectronic interconnects

    CERN Document Server

    Averbuch, A; Ravve, I

    2003-01-01

    Voids and cracks often occur in the interconnect lines of microelectronic devices. They increase the resistance of the circuits and may even lead to a fatal failure. Voids may occur inside a single grain, but often they appear on the boundary between two grains. In this work, we model and analyze numerically the migration and evolution of an intergranular void subjected to surface diffusion forces and external voltage applied to the interconnect. The grain-void interface is considered one-dimensional, and the physical formulation of the electromigration and diffusion model results in two coupled fourth-order one-dimensional time-dependent PDEs. The boundary conditions are specified at the triple points, which are common to both neighboring grains and the void. The solution of these equations uses a finite difference scheme in space and a Runge-Kutta integration scheme in time, and is also coupled to the solution of a static Laplace equation describing the voltage distribution throughout the grain. Since the v...

  4. Posterior Tibial Tendon Dysfunction

    Science.gov (United States)

    .org Posterior Tibial Tendon Dysfunction Page ( 1 ) Posterior tibial tendon dysfunction is one of the most common problems of the foot and ankle. It occurs when the posterior tibial tendon becomes inflamed or torn. As a result, the ...

  5. Numerical Simulation of Dust Void Evolution in Complex Plasmas with Ionization Effect

    Institute of Scientific and Technical Information of China (English)

    LIU Yue; WANG Zheng-Xiong; WANG Xiao-Gang

    2006-01-01

    We develop the nonlinear theory of dust voids [Phys. Rev. Lett. 90 (2003) 075001], focusing particularly on effects of the ionization, to investigate numerically the void evolution under cylindrical coordinates [Phys. Plasmas 13(2006) 064502]. The ion velocity profile is solved by a more accurate ion motion equation with the ion convection and ionization terms. It is shown that the differences between the previous result and the one obtained with ionizations are significant for the distributions of the ion and dust velocities, the dust density, and etc., in the void formation process. Furthermore, the ionization can slow down the void formation process effectively.

  6. Influence of ageing, inclusions and voids on ductile fracture mechanism in commercial Al-alloys

    Indian Academy of Sciences (India)

    A Chennakesava Reddy; S Sundar Rajan

    2005-02-01

    The objective of the paper is to study the effect of ageing, inclusions and voids on the mechanism of fracture and resultant toughness. It has been found that the voids are initiated at only a fraction of the larger inclusions present. The initiation of voids at small particles in the ductile fracture process appears to have little effect on fracture toughness. The strain hardening capacity has a marked effect on void size, and is an indicator of fracture toughness in the commercial Al alloy.

  7. Constitutive description of casting aluminum alloy based on cylindrical void-cell model

    Institute of Scientific and Technical Information of China (English)

    CHEN Bin; PENG Xiang-he; ZENG Xiang-guo; WU Xin-yan; SUN Shi-tao

    2006-01-01

    Casting aluminum alloys are highly heterogeneous materials with different types of voids that affect the mechanical properties of the material. Through the analysis ora cylindrical void-cell model the evolution equation of the voids was obtained. The evolution equation was embedded into a nonclassical elastoplastic constitutive relation, and an elastoplastic constitutive relation involving void evolution was obtained. A corresponding finite element procedure was developed and applied to the analyses of the distributions of the axial stress and porosity of notched cylindrical specimens of casting aluminum alloy A101. The computed results show good agreement with experimental data.

  8. Size effects on void growth in single crystals with distributed voids

    DEFF Research Database (Denmark)

    Borg, Ulrik; Niordson, Christian Frithiof; Kysar, J.W.

    2008-01-01

    The effect of void size on void growth in single crystals with uniformly distributed cylindrical voids is studied numerically using a finite deformation strain gradient crystal plasticity theory with an intrinsic length parameter. A plane strain cell model is analyzed for a single crystal...

  9. The darkness that shaped the void: dark energy and cosmic voids

    NARCIS (Netherlands)

    Bos, E. G. Patrick; van de Weygaert, Rien; Dolag, Klaus; Pettorino, Valeria

    2012-01-01

    We assess the sensitivity of void shapes to the nature of dark energy that was pointed out in recent studies and also investigate whether or not void shapes are useable as an observational probe in galaxy redshift surveys. Our focus is on the evolution of the mean void ellipticity and its underlying

  10. The darkness that shaped the void : Dark energy and cosmic voids

    NARCIS (Netherlands)

    Bos, E. G. Patrick; van de Weygaert, Rien; Dolag, Klaus; Pettorino, Valeria

    2012-01-01

    We assess the sensitivity of void shapes to the nature of dark energy that was pointed out in recent studies and also investigate whether or not void shapes are useable as an observational probe in galaxy redshift surveys. Our focus is on the evolution of the mean void ellipticity and its underlying

  11. Myo1e impairment results in actin reorganization, podocyte dysfunction, and proteinuria in zebrafish and cultured podocytes.

    Directory of Open Access Journals (Sweden)

    Jianhua Mao

    Full Text Available BACKGROUND: Podocytes serve as an important constituent of the glomerular filtration barrier. Recently, we and others identified Myo1e as a key molecular component of the podocyte cytoskeleton. RESULTS: Myo1e mRNA and protein was expressed in human and mouse kidney sections as determined by Northern blot and reverse transcriptase PCR, and its expression was more evident in podocytes by immunofluorescence. By specific knock-down of MYO1E in zebrafish, the injected larvae exhibited pericardial edema and pronephric cysts, consistent with the appearance of protein in condensed incubation supernate. Furthermore, specific inhibition of Myo1e expression in a conditionally immortalized podocyte cell line induced morphological changes, actin cytoskeleton rearrangement, and dysfunction in cell proliferation, migration, endocytosis, and adhesion with the glomerular basement membrane. CONCLUSIONS: Our results revealed that Myo1e is a key component contributing to the functional integrity of podocytes. Its impairment may cause actin cytoskeleton re-organization, alteration of cell shape, and membrane transport, and podocyte drop-out from the glomerular basement membrane, which might eventually lead to an impaired glomerular filtration barrier and proteinuria.

  12. Cosmological Black Holes as Seeds of Voids in Galaxy Distribution

    CERN Document Server

    Capozziello, S; Stornaiolo, C; Capozziello, Salvatore; Funaro, Maria; Stornaiolo, Cosimo

    2004-01-01

    Deep surveys indicate a bubbly structure of cosmological large scale which should be the result of evolution of primordial density perturbations. Several models have been proposed to explain origin and dynamics of such features but, till now, no exhaustive and fully consistent theory has been found. We discuss a model where cosmological black holes, deriving from primordial perturbations, are the seeds for large-scale-structure voids. We give details of dynamics and accretion of the system voids-cosmological black holes from the epochs $(z\\simeq10^{3})$ till now finding that void of $40h^{-1}Mpc$ of diameter and under-density of -0.9 will fits the observations without conflicting with the homogeneity and isotropy of cosmic microwave background radiation.

  13. Dwarf Galaxies in Voids: Dark Matter Halos and Gas Cooling

    CERN Document Server

    Hoeft, Matthias

    2010-01-01

    Galaxy surveys have shown that luminous galaxies are mainly distributed in large filaments and galaxy clusters. The remaining large volumes are virtually devoid of luminous galaxies. This is in concordance with the formation of the large-scale structure in Universe as derived from cosmological simulations. However, the numerical results indicate that cosmological voids are abundantly populated with dark matter haloes which may in principle host dwarf galaxies. Observational efforts have in contrast revealed, that voids are apparently devoid of dwarf galaxies. We investigate the formation of dwarf galaxies in voids by hydrodynamical cosmological simulations. Due to the cosmic ultra-violet background radiation low-mass haloes show generally are reduced baryon fraction. We determine the characteristic mass below which dwarf galaxies are baryon deficient. We show that the circular velocity below which the accretion of baryons is suppressed is approximately 40 km/s. The suppressed baryon accretion is caused by the...

  14. Voids in cosmological simulations over cosmic time

    CERN Document Server

    Wojtak, Radosław; Abel, Tom

    2016-01-01

    We study evolution of voids in cosmological simulations using a new method for tracing voids over cosmic time. The method is based on tracking watershed basins (contiguous regions around density minima) of well developed voids at low redshift, on a regular grid of density field. It enables us to construct a robust and continuous mapping between voids at different redshifts, from initial conditions to the present time. We discuss how the new approach eliminates strong spurious effects of numerical origin when voids evolution is traced by matching voids between successive snapshots (by analogy to halo merger trees). We apply the new method to a cosmological simulation of a standard LambdaCDM cosmological model and study evolution of basic properties of typical voids (with effective radii between 6Mpc/h and 20Mpc/h at redshift z=0) such as volumes, shapes, matter density distributions and relative alignments. The final voids at low redshifts appear to retain a significant part of the configuration acquired in in...

  15. A new geometrical approach to void statistics

    CERN Document Server

    Werner, M C

    2014-01-01

    Modelling cosmic voids as spheres in Euclidean space, the notion of a de-Sitter configuration space is introduced. It is shown that a uniform distribution over this configuration space yields a power-law approximating the void size distribution in an intermediate range of volumes, as well as an estimate for the fractal dimension of the large scale structure.

  16. Tracing the gravitational potential using cosmic voids

    CERN Document Server

    Nadathur, Seshadri; Crittenden, Robert

    2016-01-01

    The properties of large underdensities in the distribution of galaxies in the Universe, known as cosmic voids, are potentially sensitive probes of fundamental physics. We use data from the MultiDark suite of N-body simulations and multiple halo occupation distribution mocks to study the relationship between galaxy voids and the gravitational potential $\\Phi$. We find that the majority of galaxy voids correspond to local density minima in larger-scale overdensities, and thus lie in potential wells. However, a subset of voids can be identified that closely trace maxima of the gravitational potential and thus stationary points of the velocity field. We identify a new void observable, $\\lambda_v$, which depends on a combination of the void size and the average galaxy density contrast within the void, and show that it provides a good proxy indicator of the potential at the void location. A simple linear scaling of $\\Phi$ as a function of $\\lambda_v$ is found to hold, independent of the redshift and properties of t...

  17. Simulation of dust voids in complex plasmas

    NARCIS (Netherlands)

    W. J. Goedheer,; Land, V.

    2008-01-01

    In dusty radio-frequency (RF) discharges under micro-gravity conditions often a void is observed, a dust free region in the discharge center. This void is generated by the drag of the positive ions pulled out of the discharge by the electric field. We have developed a hydrodynamic model for dusty RF

  18. Assembly of filamentary void galaxy configurations

    NARCIS (Netherlands)

    Rieder, Steven; van de Weijgaert, Rien; Cautun, Marius; Beygu, Burcu; Zwart, Simon Portegies

    2013-01-01

    We study the formation and evolution of filamentary configurations of dark matter haloes in voids. Our investigation uses the high-resolution Lambda cold dark matter simulation CosmoGrid to look for void systems resembling the VGS_31 elongated system of three interacting galaxies that was recently

  19. An embryonic atrazine exposure results in reproductive dysfunction in adult zebrafish and morphological alterations in their offspring.

    Science.gov (United States)

    Wirbisky, Sara E; Weber, Gregory J; Sepúlveda, Maria S; Lin, Tsang-Long; Jannasch, Amber S; Freeman, Jennifer L

    2016-02-19

    The herbicide atrazine, a suspected endocrine disrupting chemical (EDC), frequently contaminates potable water supplies. Studies suggest alterations in the neuroendocrine system along the hypothalamus-pituitary-gonadal axis; however, most studies address either developmental, pubertal, or adulthood exposures, with few investigations regarding a developmental origins hypothesis. In this study, zebrafish were exposed to 0, 0.3, 3, or 30 parts per billion (ppb) atrazine through embryogenesis and then allowed to mature with no additional chemical exposure. Reproductive function, histopathology, hormone levels, offspring morphology, and the ovarian transcriptome were assessed. Embryonic atrazine exposure resulted in a significant increase in progesterone levels in the 3 and 30 ppb groups. A significant decrease in spawning and a significant increase in follicular atresia in the 30 ppb group were observed. In offspring, a decrease in the head length to body ratio in the 30 ppb group, along with a significant increase in head width to body ratio in the 0.3 and 3 ppb groups occurred. Transcriptomic alterations involved genes associated with endocrine system development and function, tissue development, and behavior. This study provides evidence to support atrazine as an EDC causing reproductive dysfunction and molecular alterations in adults exposed only during embryogenesis and morphological alterations in their offspring.

  20. An embryonic atrazine exposure results in reproductive dysfunction in adult zebrafish and morphological alterations in their offspring

    Science.gov (United States)

    Wirbisky, Sara E.; Weber, Gregory J.; Sepúlveda, Maria S.; Lin, Tsang-Long; Jannasch, Amber S.; Freeman, Jennifer L.

    2016-01-01

    The herbicide atrazine, a suspected endocrine disrupting chemical (EDC), frequently contaminates potable water supplies. Studies suggest alterations in the neuroendocrine system along the hypothalamus-pituitary-gonadal axis; however, most studies address either developmental, pubertal, or adulthood exposures, with few investigations regarding a developmental origins hypothesis. In this study, zebrafish were exposed to 0, 0.3, 3, or 30 parts per billion (ppb) atrazine through embryogenesis and then allowed to mature with no additional chemical exposure. Reproductive function, histopathology, hormone levels, offspring morphology, and the ovarian transcriptome were assessed. Embryonic atrazine exposure resulted in a significant increase in progesterone levels in the 3 and 30 ppb groups. A significant decrease in spawning and a significant increase in follicular atresia in the 30 ppb group were observed. In offspring, a decrease in the head length to body ratio in the 30 ppb group, along with a significant increase in head width to body ratio in the 0.3 and 3 ppb groups occurred. Transcriptomic alterations involved genes associated with endocrine system development and function, tissue development, and behavior. This study provides evidence to support atrazine as an EDC causing reproductive dysfunction and molecular alterations in adults exposed only during embryogenesis and morphological alterations in their offspring. PMID:26891955

  1. VIDE: The Void IDentification and Examination toolkit

    CERN Document Server

    Sutter, P M; Hamaus, Nico; Pisani, Alice; Wandelt, Benjamin D; Warren, Michael S; Villaescusa-Navarro, Francisco; Zivick, Paul; Mao, Qingqing; Thompson, Benjamin B

    2014-01-01

    We present VIDE, the Void IDentification and Examination toolkit, an open-source Python/C++ code for finding cosmic voids in galaxy redshift surveys and N-body simulations, characterizing their properties, and providing a platform for more detailed analysis. At its core, VIDE uses a greatly enhanced version of ZOBOV (Neyinck 2008) to calculate a Voronoi tessellation for estimating the density field and a watershed transform to construct voids. The watershed levels are used to place voids in a hierarchical tree. VIDE provides significant additional functionality for both pre- and post-processing: for example, VIDE can work with volume- or magnitude-limited galaxy samples with arbitrary survey geometries, or dark matter particles or halo catalogs in a variety of common formats. It can also randomly subsample inputs and includes a Halo Occupation Distribution model for constructing mock galaxy populations. VIDE outputs a summary of void properties in plain ASCII, and provides a Python API to perform many analysi...

  2. Determination of gas pressure in voids in epoxy casting using an ultrasonic measuring technique

    DEFF Research Database (Denmark)

    Larsen, Esben; Petersen, C. Bak; Henriksen, Mogens

    1990-01-01

    Results of measurements performed on a large open void, where pressure can be controlled from the outside, are compared to the theory of ultrasound transmission. The results verify the theory that the attenuation of transmitted ultrasonic signals through a void depends on the gas pressure inside ...

  3. Voiding trial outcome following pelvic floor repair without incontinence procedures

    Science.gov (United States)

    Wang, Rui; Won, Sara; Haviland, Miriam J.; Bargen, Emily Von; Hacker, Michele R.; Li, Janet

    2016-01-01

    Introduction and hypothesis Our aim was to identify predictors of postoperative voiding trial failure among patients who had a pelvic floor repair without a concurrent incontinence procedure in order to identify low-risk patients in whom postoperative voiding trials may be modified. Methods We conducted a retrospective cohort study of women who underwent pelvic floor repair without concurrent incontinence procedures at two institutions from 1 November 2011 through 13 October 2013 after abstracting demographic and clinical data from medical records. The primary outcome was postoperative retrograde voiding trial failure. We used modified Poisson regression to calculate the risk ratio (RR) and 95 % confidence interval (CI). Results Of the 371 women who met eligibility criteria, 294 (79.2 %) had complete data on the variables of interest. Forty nine (16.7%) failed the trial, and those women were less likely to be white (p = 0.04), more likely to have had an anterior colporrhaphy (p = 0.001), and more likely to have had a preoperative postvoid residual (PVR) ≥150 ml (p = 0.001). After adjusting for race, women were more likely to fail their voiding trial if they had a preoperative PVR of ≥150 ml (RR: 1.9; 95 % CI: 1.1–3.2); institution also was associated with voiding trial failure (RR: 3.0; 95 % CI: 1.6–5.4). Conclusions Among our cohort, postoperative voiding trial failure was associated with a PVR of ≥150 ml and institution at which the surgery was performed. PMID:26886553

  4. Formation of Voids from Negative Density Perturbations

    Science.gov (United States)

    de Araujo, J. C. N.; Opher, R.

    1990-11-01

    RESUMEN. Se estudia la formaci6n de huecos a partir de un espectro negativo de perturbaciones, tomando en cuenta la expansi6n del Universo, arrastre por fotones, enfriamiento por fotones, fotoionizaci6n, ioniza- ci6n colisional, enfriamiento Lyman a y la formaci6n y enfriamiento de moleculas H2. Nuestros resultados predicen la existencia de regiones 1/10 de Ia densidad promedio para regiones de masa lO - 1O10M . ABSTRACT. In the present paer we study the formation of voids from a negative spectrum of perturbations taking into account the expansion of the Universe, photon-drag, photon-cooling, photoionization, collisional ionization, Lyman a cooling and the formation and cooling of 112 molecules. Our results predict the existence of regions 1/10 the average density for regions of mass 1O - 1O10M@ : CLUSTERS-GALAXIES - COSMOLOGY

  5. Impaired wound healing results from the dysfunction of the Akt/mTOR pathway in diabetic rats.

    Science.gov (United States)

    Huang, Hong; Cui, Wenhui; Qiu, Wei; Zhu, Ming; Zhao, Rongshen; Zeng, Dengfen; Dong, Chenhui; Wang, Xiaohui; Guo, Wei; Xing, Wei; Li, Xiangyun; Li, Lei; Tan, Yan; Wu, Xiaofeng; Chen, Lizhao; Fu, Xiaobing; Luo, Donglin; Xu, Xiang

    2015-09-01

    Wound healing is impaired in diabetes mellitus. The underlying mechanism involved in this process is still unknown. The Akt/mTOR signaling pathway plays a crucial role in the pathogenesis of diabetes. we investigated the role of the Akt/mTOR pathway in diabetic wounds and the mechanisms that growth factors activate this pathway to promote diabetic wound healing. Full-thickness skin excisional wounds were created on the backs of normal and streptozotocin-induced diabetic rats. The expression of key proteins in the Akt/mTOR pathway was assayed using western blotting; topical effects of granulocyte-macrophage colony stimulating factor (GM-CSF) on diabetic wounds and activation of the Akt/mTOR pathway were subsequently investigated. Activation of the Akt/mTOR pathway by GM-SCF in vitro was examined in rat primary fibroblasts. The results indicate that the Akt/mTOR pathway was activated in the wound tissue of both non-diabetic and diabetic rats, as indicated by a remarkable increase in expression of total and phosphorylated key proteins in this pathway. However, the expression level of these proteins was dramatically attenuated in diabetic wounds compared with non-diabetic wounds. Upon topical application of GM-CSF, the diabetic wound healing was remarkably improved concomitantly with increased expression and phosphorylation of key proteins in the Akt/mTOR pathway. In addition, rat fibroblast proliferation induced by GM-CSF depended on the Akt/mTOR pathway activation. Impaired wound healing results from the dysfunction of the Akt/mTOR pathway in diabetic rats. The pharmacologic elevation of this pathway may represent an attractive intervention strategy to improve prognosis of diabetic wounds. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  6. Cosmic voids and void lensing in the Dark Energy Survey Science Verification data

    Energy Technology Data Exchange (ETDEWEB)

    Sánchez, C.; Clampitt, J.; Kovacs, A.; Jain, B.; García-Bellido, J.; Nadathur, S.; Gruen, D.; Hamaus, N.; Huterer, D.; Vielzeuf, P.; Amara, A.; Bonnett, C.; DeRose, J.; Hartley, W. G.; Jarvis, M.; Lahav, O.; Miquel, R.; Rozo, E.; Rykoff, E. S.; Sheldon, E.; Wechsler, R. H.; Zuntz, J.; Abbott, T. M. C.; Abdalla, F. B.; Annis, J.; Benoit-Lévy, A.; Bernstein, G. M.; Bernstein, R. A.; Bertin, E.; Brooks, D.; Buckley-Geer, E.; Rosell, A. Carnero; Kind, M. Carrasco; Carretero, J.; Crocce, M.; Cunha, C. E.; D' Andrea, C. B.; da Costa, L. N.; Desai, S.; Diehl, H. T.; Dietrich, J. P.; Doel, P.; Evrard, A. E.; Neto, A. Fausti; Flaugher, B.; Fosalba, P.; Frieman, J.; Gaztanaga, E.; Gruendl, R. A.; Gutierrez, G.; Honscheid, K.; James, D. J.; Krause, E.; Kuehn, K.; Lima, M.; Maia, M. A. G.; Marshall, J. L.; Melchior, P.; Plazas, A. A.; Reil, K.; Romer, A. K.; Sanchez, E.; Schubnell, M.; Sevilla-Noarbe, I.; Smith, R. C.; Soares-Santos, M.; Sobreira, F.; Suchyta, E.; Tarle, G.; Thomas, D.; Walker, A. R.; Weller, J.

    2016-10-26

    Galaxies and their dark matter halos populate a complicated filamentary network around large, nearly empty regions known as cosmic voids. Cosmic voids are usually identified in spectroscopic galaxy surveys, where 3D information about the large-scale structure of the Universe is available. Although an increasing amount of photometric data is being produced, its potential for void studies is limited since photometric redshifts induce line-of-sight position errors of $\\sim50$ Mpc/$h$ or more that can render many voids undetectable. In this paper we present a new void finder designed for photometric surveys, validate it using simulations, and apply it to the high-quality photo-$z$ redMaGiC galaxy sample of the Dark Energy Survey Science Verification (DES-SV) data. The algorithm works by projecting galaxies into 2D slices and finding voids in the smoothed 2D galaxy density field of the slice. Fixing the line-of-sight size of the slices to be at least twice the photo-$z$ scatter, the number of voids found in these projected slices of simulated spectroscopic and photometric galaxy catalogs is within 20% for all transverse void sizes, and indistinguishable for the largest voids of radius $\\sim 70$ Mpc/$h$ and larger. The positions, radii, and projected galaxy profiles of photometric voids also accurately match the spectroscopic void sample. Applying the algorithm to the DES-SV data in the redshift range $0.2voids with comoving radii spanning the range 18-120 Mpc/$h$, and carry out a stacked weak lensing measurement. With a significance of $4.4\\sigma$, the lensing measurement confirms the voids are truly underdense in the matter field and hence not a product of Poisson noise, tracer density effects or systematics in the data. It also demonstrates, for the first time in real data, the viability of void lensing studies in photometric surveys.

  7. Void growth to coalescence in a non-local material

    DEFF Research Database (Denmark)

    Niordson, Christian Frithiof

    The size-effect in metals containing distributed spherical voids is analyzed numerically using a finite strain generalization of a length scale dependent plasticity theory. Results are obtained for stress-triaxialities relevant in front of a crack tip in an elastic-plastic metal. The influence...

  8. Void growth to coalescence in a non-local material

    DEFF Research Database (Denmark)

    Niordson, Christian Frithiof

    2008-01-01

    The size-effect in metals containing distributed spherical voids is analyzed numerically using a finite strain generalization of a length scale dependent plasticity theory. Results are obtained for stress-triaxialities relevant in front of a crack tip in an elastic-plastic metal. The influence...

  9. An H I survey of the Bootes void .2. The analysis

    NARCIS (Netherlands)

    Szomoru, A; vanGorkom, JH; Gregg, MD; Strauss, MA

    1996-01-01

    We discuss the results of a VLA(2) [Napier et al., Proc. IEEE 71, 1295 (1983)] H I survey of the Bootes void and compare the distribution and H I properties of the void galaxies to those of galaxies found in a survey of regions of mean cosmic density. The Bootes survey covers 1100 Mpc(3), or similar

  10. Redshift-space distortions around voids

    CERN Document Server

    Cai, Yan-Chuan; Peacock, John A; Padilla, Nelson

    2016-01-01

    We have derived estimators for the linear growth rate of density fluctuations using the cross-correlation function of voids and haloes in redshift space, both directly and in Fourier form. In linear theory, this cross-correlation contains only monopole and quadrupole terms. At scales greater than the void radius, linear theory is a good match to voids traced out by haloes in N-body simulations; small-scale random velocities are unimportant at these radii, only tending to cause small and often negligible elongation of the redshift-space cross-correlation function near its origin. By extracting the monopole and quadrupole from the cross-correlation function, we measure the linear growth rate without prior knowledge of the void profile or velocity dispersion. We recover the linear growth parameter $\\beta$ to 9% precision from an effective volume of 3(Gpc/h)^3 using voids with radius greater than 25Mpc/h. Smaller voids are predominantly sub-voids, which may be more sensitive to the random velocity dispersion; the...

  11. Oral Dysfunction

    OpenAIRE

    鈴木, 規子; スズキ, ノリコ; Noriko, SUZUKI

    2004-01-01

    The major oral functions can be categorized as mastication, swallowing, speech and respiratory functions. Dysfunction of these results in dysphagia, speech disorders and abnormal respiration (such as Sleep Apnea). These functions relate to dentistry in the occurrence of : (1) oral preparatory and oral phases, (2) articulation disorders and velopharyngeal incompetence (VPI), and (3) mouth breathing, respiratory and blowing disorders. These disorders are related to oral and maxillofacial diseas...

  12. Voids' System in the Woven Composite Structure

    Institute of Scientific and Technical Information of China (English)

    Pavla VOZKOVA

    2006-01-01

    Composites are common material constructions for high-tech use now. Mechanical properties of woven reinforced composites are influenced by voids inside the structure.Voids could be classified to the two sections. Long and thin cracks are more dangerous than pores. It is important to find relations between preparation and place of occurrence of voids. This paper classifies defects according to rise mechanism, point of occurrence, orientation, size and affect to the properties. Image analysis was used for observing samples. Future work would be oriented not only to observing real samples, but also to calculate mechanical properties from real and ideal structures in 3D woven reinforced composites.

  13. Practical Statistics for the Voids Between Galaxies

    Directory of Open Access Journals (Sweden)

    Zaninetti, L.

    2010-12-01

    Full Text Available The voids between galaxies are identified withthe volumes of the Poisson Voronoi tessellation.Two new survival functions for the apparent radii of voids are derived. The sectional normalized area ofthe Poisson Voronoi tessellation is modelledby the Kiang function and by the exponential function. Two new survival functions with equivalent sectional radius are therefore derived; they represent an alternative to the survival function of voids between galaxies as given by the self-similar distribution. The spatial appearance of slices of the 2dF Galaxy Redshift Survey is simulated.

  14. 34例慢性盆底功能障碍骶神经调节治疗的测试结果观察%Test results of sacral neuromodulation in 34 patients with chronic pelvic floor dysfunction

    Institute of Scientific and Technical Information of China (English)

    卫中庆; 沈百欣; 丁留成; 易超然; 丁曙晴; 于洪波; 文伟; 孙则禹; PhilipVanKerrebroeck

    2012-01-01

    Objective To investigate the therapeutic effect and safety of temporary electrode and Tined Lead electrode in Bacral neuromodulation evaluation. Methods Thirty-four patients with chronic pelvic floor dysfunction were divided into temporary electrode group (n = 16) and Tined Lead electrode group (n = 18), and temporary stimulation tests were performed after electrode placement. The conditions of voiding and defecation were recorded every day, and related urodynamic parameters were measured. Results The symptoms improved in 43% patients with urgent incontinence and 35% patients with urinary frequency and urgency, and 10% patients with urgent incontinence or urinary frequency and urgency were cured. There were significant differences in the rates of self-perceived improvement of voiding and defecation between temporary electrode group and Tined Lead electrode group (32.2% vs 38. 2% , P 0.0S) . Electrode shift took place in 4 patients in temporary electrode group and in 1 patient in Tined Lead electrode group. Conclusion Sacral neuromodulation is a safe, minimally invasive and effective method for treatment of chronic pelvic floor dysfunction, and Tined Lead electrode may prevent the electrode shift, increase the rate of success, and improve the therapeutic effect.%目的 探讨骶神经调节测试评估阶段临时电极及自固定例齿状( Tined Lead)电极的疗效及安全性.方法 将34例慢性盆底功能障碍患者按电极置入方法不同分为临时电极组(n=16)和自固定Tined Lead电极组(n=18),并进行术后两种电极临时刺激测试.在测试期记录排尿排便日记,进行相关尿动力学参数测定.结果 急迫性尿失禁患者中,有43%症状改善;尿频尿急患者中有35%症状改善;10%的急迫性尿失禁/尿频尿急患者治愈.临时电极组患者排尿排便自我感觉的改善率为32.2%,自固定Tined Lead电极组为38.2%,两组差异有统计学意义(P<0.05).盆底疼痛综合征/间质性膀胱

  15. Cosmic voids and void lensing in the Dark Energy Survey Science Verification data

    Science.gov (United States)

    Sánchez, C.; Clampitt, J.; Kovacs, A.; Jain, B.; García-Bellido, J.; Nadathur, S.; Gruen, D.; Hamaus, N.; Huterer, D.; Vielzeuf, P.; Amara, A.; Bonnett, C.; DeRose, J.; Hartley, W. G.; Jarvis, M.; Lahav, O.; Miquel, R.; Rozo, E.; Rykoff, E. S.; Sheldon, E.; Wechsler, R. H.; Zuntz, J.; Abbott, T. M. C.; Abdalla, F. B.; Annis, J.; Benoit-Lévy, A.; Bernstein, G. M.; Bernstein, R. A.; Bertin, E.; Brooks, D.; Buckley-Geer, E.; Rosell, A. Carnero; Kind, M. Carrasco; Carretero, J.; Crocce, M.; Cunha, C. E.; D'Andrea, C. B.; da Costa, L. N.; Desai, S.; Diehl, H. T.; Dietrich, J. P.; Doel, P.; Evrard, A. E.; Neto, A. Fausti; Flaugher, B.; Fosalba, P.; Frieman, J.; Gaztanaga, E.; Gruendl, R. A.; Gutierrez, G.; Honscheid, K.; James, D. J.; Krause, E.; Kuehn, K.; Lima, M.; Maia, M. A. G.; Marshall, J. L.; Melchior, P.; Plazas, A. A.; Reil, K.; Romer, A. K.; Sanchez, E.; Schubnell, M.; Sevilla-Noarbe, I.; Smith, R. C.; Soares-Santos, M.; Sobreira, F.; Suchyta, E.; Tarle, G.; Thomas, D.; Walker, A. R.; Weller, J.; DES Collaboration

    2017-02-01

    Cosmic voids are usually identified in spectroscopic galaxy surveys, where 3D information about the large-scale structure of the Universe is available. Although an increasing amount of photometric data is being produced, its potential for void studies is limited since photometric redshifts induce line-of-sight position errors of ≥50 Mpc h-1which can render many voids undetectable. We present a new void finder designed for photometric surveys, validate it using simulations, and apply it to the high-quality photo-z redMaGiC galaxy sample of the DES Science Verification data. The algorithm works by projecting galaxies into 2D slices and finding voids in the smoothed 2D galaxy density field of the slice. Fixing the line-of-sight size of the slices to be at least twice the photo-z scatter, the number of voids found in simulated spectroscopic and photometric galaxy catalogues is within 20 per cent for all transverse void sizes, and indistinguishable for the largest voids (Rv ≥ 70 Mpc h-1). The positions, radii, and projected galaxy profiles of photometric voids also accurately match the spectroscopic void sample. Applying the algorithm to the DES-SV data in the redshift range 0.2 < z < 0.8, we identify 87 voids with comoving radii spanning the range 18-120 Mpc h-1, and carry out a stacked weak lensing measurement. With a significance of 4.4σ, the lensing measurement confirms that the voids are truly underdense in the matter field and hence not a product of Poisson noise, tracer density effects or systematics in the data. It also demonstrates, for the first time in real data, the viability of void lensing studies in photometric surveys.

  16. Study of the effect of void surface coatings on radiation-induced swelling

    Energy Technology Data Exchange (ETDEWEB)

    Mansur, L.K.; Wolfer, W.G.

    1977-09-01

    A theoretical investigation has been conducted into the effects on point defect diffusion of the presence of a shell of segregated material about a spherical void. The elastic image interaction of the point defect with the void surrounded by a shell of material of elastic constants which differ from those on the matrix is first computed. The interaction, which depends on the properties of the shell and the dilatation of the defect, results in an energy barrier which must be overcome when the defect diffuses to the void surface. The capture efficiency of the void for the defect is computed for a range of parameters employing this interaction. This capture efficiency is then used directly to obtain predicted effects of segregation on void nucleation and growth under irradiation. It is found that the absorption of the interstitial is reaction controlled at the void. The principal implications are that void nucleation is strongly enhanced and that the kinetics of void growth are altered significantly. Detailed derivations supporting these results are given.

  17. A molecular dynamics study of void initiation and growth in monocrystalline and nanocrystalline copper

    Science.gov (United States)

    Traiviratana, Sirirat

    MD simulations in monocrystalline and nanocrystalline copper were carried out with LAMMPS to reveal void growth mechanisms. The specimens were subjected to both tensile uniaxial and hydrostatic strains; the results confirm that the emission of (shear) loops is the primary mechanism of void growth. The expansion of the loops and their cross slip leads to the severely work hardened layer surrounding a growing void. Calculations were carried out on voids with different sizes, and a size dependence of the stress response to emitted dislocations was observed, in disagreement with the Gurson model [1] which is scale independent. The growth of voids simulated by MD is compared with the Cocks-Ashby constitutive model and significant agreement is found. The density of geometrically-necessary dislocations as a function of void size is calculated based on the emission of shear loops and their outward propagation. Calculations were also carried out for a void at the interface between two grains sharing a tilt boundary. The results show similar dislocation behaviors. A code that uses Voronoi tessellation for constructing nanocrystalline structures was developed and used to prepare the structures for simulations. Nanocrystal simulations reveal grain sliding and grain rotation as the nanocrystal deformed. Voids were nucleated at grain junctions and grew to coalescence as dislocations accommodated the material transfer. A code that can be used during post-processing to extract useful dislocation information from MD simulation data was partially developed and proved the feasibility of automatically analyzing dislocations.

  18. The results of correction of endothelial dysfunction in type 2 diabetes mellitus in patients with diabetic retinopathy and associated hypertension

    Directory of Open Access Journals (Sweden)

    L. K. Moshetova

    2013-01-01

    ischemic (Semaks therapy on clinical and functional and morphological parameters of the retina in patients with retinopathy in type 2 diabetes in combination with GB. NOx reduction in the tear fluid and serum was associated with decreased severity of clinical symptoms DR I and II, the resulting vascular endothelial dysfunction. This allows us to consider this as an effective therapeutic intervention aimed at preventing the onset and progression of retinopathy in the combined course of type 2 diabetes and hypertension.

  19. Topology optimization with flexible void area

    DEFF Research Database (Denmark)

    Clausen, Anders; Aage, Niels; Sigmund, Ole

    2014-01-01

    This paper presents a methodology for including fixed-area flexible void domains into the minimum compliance topology optimization problem. As opposed to the standard passive elements approach of rigidly specifying void areas within the design domain, the suggested approach allows these areas...... to be flexibly reshaped and repositioned subject to penalization on their moments of inertia, the positions of their centers of mass, and their shapes. The flexible void areas are introduced through a second, discrete design variable field, using the same discretization as the standard field of continuous...... density variables. The formulation is based on a combined approach: The primary sub-problem is to minimize compliance, subject to a volume constraint, with a secondary sub-problem of minimizing the disturbance from the flexible void areas. The design update is performed iteratively between the two...

  20. Neutron Imaging Calibration to Measure Void Fraction

    Energy Technology Data Exchange (ETDEWEB)

    Geoghegan, Patrick J [ORNL; Bilheux, Hassina Z [ORNL; Sharma, Vishaldeep [ORNL; Fricke, Brian A [ORNL

    2015-01-01

    Void fraction is an intuitive parameter that describes the fraction of vapor in a two-phase flow. It appears as a key variable in most heat transfer and pressure drop correlations used to design evaporating and condensing heat exchangers, as well as determining charge inventory in refrigeration systems. Void fraction measurement is not straightforward, however, and assumptions on the invasiveness of the measuring technique must be made. Neutron radiography or neutron imaging has the potential to be a truly non-invasive void fraction measuring technique but has until recently only offered qualitative descriptions of two-phase flow, in terms of flow maldistributions, for example. This paper describes the calibration approach necessary to employ neutron imaging to measure steady-state void fraction. Experiments were conducted at the High Flux Isotope Reactor (HFIR) Cold Guide 1D neutron imaging facility at Oak Ridge National Laboratory (ORNL), Oak Ridge, TN, USA.

  1. Experimental facility and void fraction calibration methods for impedance probes

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Fernando L. de; Rocha, Marcelo S., E-mail: floliveira@ipen.br, E-mail: msrocha@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    An experimental facility was designed and constructed with aims of to calibrate a capacitance probe for gas-liquid flow void fraction measurements. The facility is composed of a metallic hack with a vertical 2,300 mm high glass tube with 38 mm ID with stagnant water and compressed air bubbling system simulating the gas phase (vapor). At the lower part, a mixing section with a porous media element releases the air bubbles into the water, and the compressed air flow is measured by two calibrated rotameters. At the upper part a stagnant water tank separates the liquid and gas. Two pressure taps are located near the lower and upper sides of the glass tube for pressure difference measurement. The pressure difference is used for low void fraction values (0-15%) calibration methods, as described in the work. Two electrically controlled quick closing valves are installed between the porous media element and the upward separation tank for high void fraction values measurement (15-50%) used to calibrate the capacitance probe. The experimental facility design, construction, capacitance probe calibration methods and results, as well as flow pattern visualization, are presented. Finally, the capacitance probe will be installed on a natural circulation circuit mounted at the Nuclear Engineering Center (CEN/IPEN/CNEN-SP) for measurement of the instantaneous bulk void. Instantaneous signals generated by the capacitance probe will allow the determination of natural circulation loop global energy balance. (author)

  2. Compensation for air voids in photoacoustic computed tomography image reconstruction

    Science.gov (United States)

    Matthews, Thomas P.; Li, Lei; Wang, Lihong V.; Anastasio, Mark A.

    2016-03-01

    Most image reconstruction methods in photoacoustic computed tomography (PACT) assume that the acoustic properties of the object and the surrounding medium are homogeneous. This can lead to strong artifacts in the reconstructed images when there are significant variations in sound speed or density. Air voids represent a particular challenge due to the severity of the differences between the acoustic properties of air and water. In whole-body small animal imaging, the presence of air voids in the lungs, stomach, and gastrointestinal system can limit image quality over large regions of the object. Iterative reconstruction methods based on the photoacoustic wave equation can account for these acoustic variations, leading to improved resolution, improved contrast, and a reduction in the number of imaging artifacts. However, the strong acoustic heterogeneities can lead to instability or errors in the numerical wave solver. Here, the impact of air voids on PACT image reconstruction is investigated, and procedures for their compensation are proposed. The contributions of sound speed and density variations to the numerical stability of the wave solver are considered, and a novel approach for mitigating the impact of air voids while reducing the computational burden of image reconstruction is identified. These results are verified by application to an experimental phantom.

  3. Effect of void structure of photocatalyst paper on VOC decomposition.

    Science.gov (United States)

    Fukahori, Shuji; Iguchi, Yumi; Ichiura, Hideaki; Kitaoka, Takuya; Tanaka, Hiroo; Wariishi, Hiroyuki

    2007-02-01

    TiO2 powder-containing paper composites, called TiO2 paper, were prepared by a papermaking technique, and their photocatalytic efficiency was investigated. The TiO2 paper has a porous structure originating from the layered pulp fiber network, with TiO2 powders scattered on the fiber matrix. Under UV irradiation, the TiO2 paper decomposed gaseous acetaldehyde more effectively than powdery TiO2 and a pulp/TiO2 mixture not in paper form. Scanning electron microscopy and mercury intrusion analysis revealed that the TiO2 paper had characteristic unique voids ca. 10 microm in diameter, which might have contributed to the improved photocatalytic performance. TiO2 paper composites having different void structures were prepared by using beaten pulp fibers with different degrees of freeness and/or ceramic fibers. The photodecomposition efficiency was affected by the void structure of the photocatalyst paper, and the initial degradation rate of acetaldehyde increased with an increase in the total pore volume of TiO2 paper. The paper voids presumably provided suitable conditions for TiO2 catalysis, resulting in higher photocatalytic performance by TiO2 paper than by TiO2 powder and a pulp/TiO2 mixture not in paper form.

  4. An HI survey of the bootes void; 2, the analysis

    CERN Document Server

    Szomoru, A; Gregg, M D; Strauss, M A

    1995-01-01

    We discuss the results of a VLA HI survey of the Bootes void and compare the distribution and HI properties of the void galaxies to those of galaxies found in a survey of regions of mean cosmic density. The Bootes survey covers 1100 Mpc^{3}, or \\sim 1\\% of the volume of the void and consists of 24 cubes of typically 2 Mpc * 2 Mpc * 1280 km/s, centered on optically known galaxies. Sixteen targets were detected in HI; 18 previously uncataloged objects were discovered directly in HI. The control sample consists of 12 cubes centered on IRAS selected galaxies with FIR luminosities similar to those of the Bootes targets and located in regions of 1 to 2 times the cosmic mean density. In addition to the 12 targets 29 companions were detected in HI. We find that the number of galaxies within 1 Mpc of the targets is the same to within a factor of two for void and control samples, and thus that the small scale clustering of galaxies is the same in regions that differ by a factor of \\sim 6 in density on larger scales. A ...

  5. Zipf's law for fractal voids and a new void-finder

    CERN Document Server

    Gaite, J

    2005-01-01

    Voids are a prominent feature of fractal point distributions but there is no precise definition of what is a void (except in one dimension). Here we propose a definition of voids that uses methods of discrete stochastic geometry, in particular, Delaunay and Voronoi tessellations, and we construct a new algorithm to search for voids in a point set. We find and rank-order the voids of suitable examples of fractal point sets in one and two dimensions to test whether Zipf's power-law holds. We conclude affirmatively and, furthermore, that the rank-ordering of voids conveys similar information to the number-radius function, as regards the scaling regime and the transition to homogeneity. So it is an alternative tool in the analysis of fractal point distributions with crossover to homogeneity and, in particular, of the distribution of galaxies.

  6. Sexual dysfunction during treatment of major depressive disorder with vilazodone, citalopram, or placebo: results from a phase IV clinical trial

    OpenAIRE

    Clayton, Anita H.; Gommoll, Carl; Chen, Dalei; Nunez, Rene; Mathews, Maju

    2015-01-01

    Sexual dysfunction commonly occurs with major depressive disorder (MDD). Vilazodone, a selective serotonin reuptake inhibitor and 5-HT1A receptor partial agonist antidepressant approved for the treatment of MDD in adults, was evaluated to determine its effects on sexual function. The primary study was a double-blind, randomized, controlled trial comparing vilazodone 20 and 40 mg/day with placebo; citalopram 40 mg/day was an active control (NCT01473381; http://www.clinicaltrials.gov). Post-hoc...

  7. Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL, and results in arteriovenous malformations

    OpenAIRE

    Kofler, Natalie M.; Henar Cuervo; Uh, Minji K.; Aino Murtomäki; Jan Kitajewski

    2015-01-01

    Pericytes regulate vessel stability and pericyte dysfunction contributes to retinopathies, stroke, and cancer. Here we define Notch as a key regulator of pericyte function during angiogenesis. In Notch1 +/−; Notch3 −/− mice, combined deficiency of Notch1 and Notch3 altered pericyte interaction with the endothelium and reduced pericyte coverage of the retinal vasculature. Notch1 and Notch3 were shown to cooperate to promote proper vascular basement membrane formation and contribute to endothel...

  8. In search of empty places: Voids in the distribution of galaxies

    Science.gov (United States)

    Bucklein, Brian K.

    2010-12-01

    We investigate several techniques to identify voids in the galaxy distribution of matter in the universe. We utilize galaxy number counts as a function of apparent magnitude and Wolf plots to search a two- or three-dimensional data set in a pencil-beam fashion to locate voids within the field of view. The technique is able to distinguish between voids that represent simply a decrease in density as well as those that show a build up of galaxies on the front or back side of the void. This method turns out to be primarily useable only at relatively short range (out to about 200 Mpc). Beyond this distance, the characteristics indicating a void become increasingly difficult to separate from the statistical background noise. We apply the technique to a very simplified model as well as to the Millennium Run dark matter simulation. We then compare results with those obtained on the Sloan Digital Sky Survey. We also created the Watershed Void Examiner (WaVE) which treats densities in a fashion similar to elevation on a topographical map, and then we allow the "terrain" to flood. The flooded low-lying regions are identified as voids, which are allowed to grow and merge as the level of flooding becomes higher (the overdensity threshold increases). Void statistics can be calculated for each void. We also determine that within the Millennium Run semi-analytic galaxy catalog, the walls that separate the voids are permeable at a scale of 4 Mpc. For each resolution that we tested, there existed a characteristic density at which the walls could be penetrated, allowing a single void to grow to dominate the volume. With WaVE, we are able to get comparable results to those previously published, but often with fewer choices of parameters that could bias the results. We are also able to determine the the density at which the number of voids peaks for different resolutions as well as the expected number of void galaxies. The number of void galaxies is amazingly consistent at an

  9. Parallel Void Thread in Long-Reach Ethernet Passive Optical Networks

    KAUST Repository

    Elrasad, Amr

    2015-06-25

    This work investigates void filling (idle periods) in long-reach Ethernet passive optical networks. We focus on reducing grant delays and hence reducing the average packet delay. We introduce a novel approach called parallel void thread (PVT), which allocates bandwidth grants during voids baseless of bandwidth requests. We introduce three different grant sizing schemes for PVT, namely void extension, count controlled batch void filling, and size controlled batch void filling. The proposed approaches canbe integrated with almost all of the previously reported dynamic bandwidth allocation schemes. Unlike other void filling schemes, PVT is less sensitive to the differential distance between optical network units and can work very well in the case of limited differential distances. We have analytically investigated the packet delay and derived a bound condition for PVT to outperform the other competitors. We support our work with extensive simulation study considering bursty traffic with long range dependence for both the single-class and differentiated services (DiffServ) scenarios. Numerical results show delay reduction up to 35% compared with the non-void filling scheme for the single-class scenario. For DiffServ traffic, PVT achieves delay reduction up to 80% for expedited forward traffic, 52% for assured forward traffic, and 56% for best effort traffic. © 2015 OSA.

  10. Sexual dysfunction during treatment of major depressive disorder with vilazodone, citalopram, or placebo: results from a phase IV clinical trial.

    Science.gov (United States)

    Clayton, Anita H; Gommoll, Carl; Chen, Dalei; Nunez, Rene; Mathews, Maju

    2015-07-01

    Sexual dysfunction commonly occurs with major depressive disorder (MDD). Vilazodone, a selective serotonin reuptake inhibitor and 5-HT1A receptor partial agonist antidepressant approved for the treatment of MDD in adults, was evaluated to determine its effects on sexual function. The primary study was a double-blind, randomized, controlled trial comparing vilazodone 20 and 40 mg/day with placebo; citalopram 40 mg/day was an active control (NCT01473381; http://www.clinicaltrials.gov). Post-hoc analyses evaluated change from baseline to week 10 on the Changes in Sexual Functioning Questionnaire (CSFQ); no inferential statistics were performed. CSFQ scores increased for women [1.2 (citalopram) to 3.0 (vilazodone 40 mg)] and men [1.2 (vilazodone 40 mg) to 3.5 (placebo)] in all treatment groups. Greater changes in CSFQ scores were seen in responders [women: 2.33 (citalopram) to 5.06 (vilazodone 40 mg); men: 2.26 (vilazodone 40 mg) to 4.35 (placebo)] versus nonresponders. CSFQ change from baseline was small for patients with normal baseline sexual function; in patients with baseline sexual dysfunction, CSFQ scores improved across groups [women: 2.35 (citalopram) to 4.52 (vilazodone 40 mg); men 2.83 (vilazodone 40 mg) to 6.43 (placebo)]. Across treatment groups, baseline sexual function improved in women and men, MDD responders, and patients with baseline sexual dysfunction.

  11. Active Adoption of Void Formation in Metal-Oxide for All Transparent Super-Performing Photodetectors

    Science.gov (United States)

    Patel, Malkeshkumar; Kim, Hong-Sik; Park, Hyeong-Ho; Kim, Joondong

    2016-05-01

    Could ‘defect-considered’ void formation in metal-oxide be actively used? Is it possible to realize stable void formation in a metal-oxide layer, beyond unexpected observations, for functional utilization? Herein we demonstrate the effective tailoring of void formation of NiO for ultra-sensitive UV photodetection. NiO was formed onto pre-sputtered ZnO for a large size and spontaneously formed abrupt p-NiO/n-ZnO heterojunction device. To form voids at an interface, rapid thermal process was performed, resulting in highly visible light transparency (85–95%). This heterojunction provides extremely low saturation current (effect) for effective photoelectric device applications. We propose that the active adoption of ‘defect-considered’ Kirkendall-voids will open up a new era for metal-oxide based photoelectric devices.

  12. Active infrared thermography for visualizing subsurface micro voids in an epoxy molding compound

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Ji Yeol [Test and Package Center, Samsung Electronics, Asan(Korea, Republic of); Hwang, Soon Kyu; Choi, Jae Mook; Sohn, Hoon [Dept. of Civil and Environmental Engineering, Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

    2017-04-15

    This paper presents an automated subsurface micro void detection technique based on pulsed infrared thermography for inspecting epoxy molding compounds (EMC) used in electronic device packaging. Subsurface micro voids are first detected and visualized by extracting a lock-in amplitude image from raw thermal images. Binary imaging follows to achieve better visualization of subsurface micro voids. A median filter is then applied for removing sparse noise components. The performance of the proposed technique is tested using 36 EMC samples, which have subsurface (below 150 μm ~ 300 μm from the inspection surface) micro voids (150 μm ~ 300 μm in diameter). The experimental results show that the subsurface micro voids can be successfully detected without causing any damage to the EMC samples, making it suitable for automated online inspection.

  13. Influence investigation of a void region on modeling light propagation in a heterogeneous medium.

    Science.gov (United States)

    Yang, Defu; Chen, Xueli; Ren, Shenghan; Qu, Xiaochao; Tian, Jie; Liang, Jimin

    2013-01-20

    A void region exists in some biological tissues, and previous studies have shown that inaccurate images would be obtained if it were not processed. A hybrid radiosity-diffusion method (HRDM) that couples the radiosity theory and the diffusion equation has been proposed to deal with the void problem and has been well demonstrated in two-dimensional and three-dimensional (3D) simple models. However, the extent of the impact of the void region on the accuracy of modeling light propagation has not been investigated. In this paper, we first implemented and verified the HRDM in 3D models, including both the regular geometries and a digital mouse model, and then investigated the influences of the void region on modeling light propagation in a heterogeneous medium. Our investigation results show that the influence of the region can be neglected when the size of the void is less than a certain range, and other cases must be taken into account.

  14. A statistical mechanics model to predict electromigration induced damage and void growth in solder interconnects

    Science.gov (United States)

    Wang, Yuexing; Yao, Yao; Keer, Leon M.

    2017-02-01

    Electromigration is an irreversible mass diffusion process with damage accumulation in microelectronic materials and components under high current density. Based on experimental observations, cotton type voids dominate the electromigration damage accumulation prior to cracking in the solder interconnect. To clarify the damage evolution process corresponding to cotton type void growth, a statistical model is proposed to predict the stochastic characteristic of void growth under high current density. An analytical solution of the cotton type void volume growth over time is obtained. The synchronous electromigration induced damage accumulation is predicted by combining the statistical void growth and the entropy increment. The electromigration induced damage evolution in solder joints is developed and applied to verify the tensile strength deterioration of solder joints due to electromigration. The predictions agree well with the experimental results.

  15. Numerical Study of Void Fraction Distribution Propagation in Gas-Liquid Two-Phase Flow

    Institute of Scientific and Technical Information of China (English)

    YANG Jianhui; LI Qing; LU Wenqiang

    2005-01-01

    A dynamic propagation model was developed for waves in two-phase flows by assuming that continuity waves and dynamic waves interact nonlinearly for certain flow conditions. The drift-flux model is solved with the one-dimensional continuity equation for gas-liquid two-phase flows as an initial-boundary value problem solved using the characteristic-curve method. The numerical results give the void fraction distribution propagation in a gas-liquid two-phase flow which shows how the flow pattern transition occurs. The numerical simulations of different flow patterns show that the void fraction distribution propagation is determined by the characteristics of the drift-flux between the liquid and gas flows and the void fraction range. Flow pattern transitions begin around a void fraction of 0.27 and end around 0.58. Flow pattern transitions do not occur for very high void concentrations.

  16. Spin alignment of dark matter haloes in the shells of the largest voids

    CERN Document Server

    Cuesta, A J; Gottlöber, S; Patiri, S G; Yepes, G; Prada, F

    2007-01-01

    Using the high resolution cosmological N-body simulation MareNostrum Universe we study the orientation of shape and angular momentum of galaxy-size dark matter haloes around large voids. We find that haloes located on the shells of the largest cosmic voids have angular momenta that tend to be preferentially perpendicular to the direction that joins the centre of the halo and the centre of the void. This alignment has been found in spiral galaxies around voids using galaxy redshift surveys. We measure for the first time the strength of this alignment, showing how it falls off with increasing distance to the centre of the void. We also confirm the correlation between the intensity of this alignment and the halo mass. The analysis of the orientation of the halo main axes confirms the results of previous works. Moreover, we find a similar alignment for the baryonic matter inside dark matter haloes, which is much stronger in their inner parts.

  17. Blind void filling in LR-EPONs: How efficient it can be?

    KAUST Repository

    Elrasad, Amr

    2015-07-01

    This work proposes a novel blind void (idle periods) filling in Long-Reach Ethernet Passive Optical Networks (LR-EPONs) namely Size Controlled Batch Void Filling (SCBVF). We emphasize on reducing grant delays and hence reducing the average packet delay. SCBVF delay reduction is achieved by early flushing data during the idle time periods (voids) between allocated grants. The proposed approach can be integrated with almost all of the previously reported dynamic bandwidth allocation schemes. SCBVF is less sensitive to differential distance between ONUs and can work well in case of small differential distances compared to previously reported void filling schemes. We support our work by extensive simulation study considering bursty traffic with long range dependency. Numerical results show a delay reduction up to 35% compared to non-void filling scheme outperforming its main competitors that can achieve up to 7% delay reduction.

  18. Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial

    Science.gov (United States)

    Hoy, Anna M.; Semple, Scott I.; Mungall, Will; Lennen, Ross J.; Moran, Carmel M.; Pellicoro, Antonella; Aucott, Rebecca L.; Severin, Thomas; Saini, Rajnish; Yates, Denise; Dongre, Neelesh; Duffield, Jeremy S.; Webb, David J.; Iredale, John P.; Hayes, Peter C.

    2017-01-01

    Background Chronic liver scarring from any cause leads to cirrhosis, portal hypertension, and a progressive decline in renal blood flow and renal function. Extreme renal vasoconstriction characterizes hepatorenal syndrome, a functional and potentially reversible form of acute kidney injury in patients with advanced cirrhosis, but current therapy with systemic vasoconstrictors is ineffective in a substantial proportion of patients and is limited by ischemic adverse events. Serelaxin (recombinant human relaxin-2) is a peptide molecule with anti-fibrotic and vasoprotective properties that binds to relaxin family peptide receptor-1 (RXFP1) and has been shown to increase renal perfusion in healthy human volunteers. We hypothesized that serelaxin could ameliorate renal vasoconstriction and renal dysfunction in patients with cirrhosis and portal hypertension. Methods and findings To establish preclinical proof of concept, we developed two independent rat models of cirrhosis that were characterized by progressive reduction in renal blood flow and glomerular filtration rate and showed evidence of renal endothelial dysfunction. We then set out to further explore and validate our hypothesis in a phase 2 randomized open-label parallel-group study in male and female patients with alcohol-related cirrhosis and portal hypertension. Forty patients were randomized 1:1 to treatment with serelaxin intravenous (i.v.) infusion (for 60 min at 80 μg/kg/d and then 60 min at 30 μg/kg/d) or terlipressin (single 2-mg i.v. bolus), and the regional hemodynamic effects were quantified by phase contrast magnetic resonance angiography at baseline and after 120 min. The primary endpoint was the change from baseline in total renal artery blood flow. Therapeutic targeting of renal vasoconstriction with serelaxin in the rat models increased kidney perfusion, oxygenation, and function through reduction in renal vascular resistance, reversal of endothelial dysfunction, and increased activation of the

  19. In Situ Void Fraction and Gas Volume in Hanford Tank 241-SY-101 as Measured with the Void Fraction Instrument

    Energy Technology Data Exchange (ETDEWEB)

    CW Stewart; G Chen; JM Alzheimer; PA Meyer

    1998-11-10

    The void fraction instrument (WI) was deployed in Tank 241-SY-101 three times in 1998 to confm and locate the retained gas (void) postulated to be causing the accelerating waste level rise observed since 1995. The design, operation, and data reduction model of the WI are described along with validation testing and potential sources of uncertainty. The test plans, field observations and void measurements are described in detail, including the total gas volume calculations and the gas volume model. Based on 1998 data, the void fraction averaged 0.013 i 0.001 in the mixed slurry and 0.30 ~ 0.04 in the crust. This gives gas volumes (at standard pressure and temperature) of 87 t 9 scm in the slurry and 138 ~ 22 scm in the crust for a total retained gas volume of221 *25 scm. This represents an increase of about 74 scm in the crust and a decrease of about 34 scm in the slurry from 1994/95 results. The overall conclusion is that the gas retention is occurring mainly in the crust layer and there is very little gas in the mixed slurry and loosely settled layers below. New insights on crust behavior are also revealed.

  20. On the linearity of tracer bias around voids

    Science.gov (United States)

    Pollina, Giorgia; Hamaus, Nico; Dolag, Klaus; Weller, Jochen; Baldi, Marco; Moscardini, Lauro

    2017-07-01

    The large-scale structure of the Universe can be observed only via luminous tracers of the dark matter. However, the clustering statistics of tracers are biased and depend on various properties, such as their host-halo mass and assembly history. On very large scales, this tracer bias results in a constant offset in the clustering amplitude, known as linear bias. Towards smaller non-linear scales, this is no longer the case and tracer bias becomes a complicated function of scale and time. We focus on tracer bias centred on cosmic voids, i.e. depressions of the density field that spatially dominate the Universe. We consider three types of tracers: galaxies, galaxy clusters and active galactic nuclei, extracted from the hydrodynamical simulation Magneticum Pathfinder. In contrast to common clustering statistics that focus on auto-correlations of tracers, we find that void-tracer cross-correlations are successfully described by a linear bias relation. The tracer-density profile of voids can thus be related to their matter-density profile by a single number. We show that it coincides with the linear tracer bias extracted from the large-scale auto-correlation function and expectations from theory, if sufficiently large voids are considered. For smaller voids we observe a shift towards higher values. This has important consequences on cosmological parameter inference, as the problem of unknown tracer bias is alleviated up to a constant number. The smallest scales in existing data sets become accessible to simpler models, providing numerous modes of the density field that have been disregarded so far, but may help to further reduce statistical errors in constraining cosmology.

  1. Exploring Cosmic Voids with GALEX: Stellar Populations and Primordial Jeans Mass Objects

    Science.gov (United States)

    Gregg, Michael

    . Such primordial Jeans mass objects are predicted by theory to exist in voids. Finding them would shed light on the earliest epoch of structure formation in the Universe, while a null result would test theories of cold dark matter and structure formation in critical ways. Most of this research relies on archival data and is enabled particularly by GALEX near and far ultraviolet photometry. Sloan Digital Sky Survey data also play a key role. We will employ stellar population modeling to derive ages and star formation rates for void galaxies, gaining insight into their evolutionary history, past, present, and future. We will obtain follow-up ground-based longslit and multifiber spectroscopy to support the results of the GALEX-SDSS studies, particularly the searches for additional early type galaxies and primordial Jeans mass objects. By sheer weight of numbers, this program will dwarf previous photometric studies of void galaxies, and applying GALEX in a systematic way opens new windows on void galaxy evolution and stellar populations. The search for Jeans mass objects in voids, whether positive or null, will have profound implications for galaxy and large scale structure formation and evolution, testing critical tenets of cold dark matter hierarchical galaxy formation, directly probing the origin of structure in the Universe on galactic and super-galactic scales.

  2. The lensing and temperature imprints of voids on the cosmic microwave background

    Science.gov (United States)

    Cai, Yan-Chuan; Neyrinck, Mark; Mao, Qingqing; Peacock, John A.; Szapudi, Istvan; Berlind, Andreas A.

    2017-04-01

    We have searched for the signature of cosmic voids in the cosmic microwave background (CMB), in both the Planck temperature and lensing-convergence maps; voids should give decrements in both. We use ZOBOV voids from the Data Release 12 Sloan Digital Sky Survey CMASS galaxy sample. We base our analysis on N-body simulations, to avoid a posteriori bias. For the first time, we detect the signature of voids in CMB lensing: the significance is 3.2σ, close to Λ cold dark matter (ΛCDM) in both amplitude and projected density-profile shape. A temperature dip is also seen, at modest significance (2.3σ), with an amplitude about six times the prediction. This temperature signal is induced mostly by voids with radii between 100 and 150 h-1 Mpc, while the lensing signal is mostly contributed by smaller voids - as expected; lensing relates directly to density, while integrated Sachs-Wolfe effect (ISW) depends on gravitational potential. The void abundance in observations and simulations agree as well. We also repeated the analysis excluding lower significance voids: no lensing signal is detected with an upper limit of about twice the ΛCDM prediction. But the mean temperature decrement now becomes non-zero at the 3.7σ level (similar to that found by Granett et al.), with an amplitude about 20 times the prediction. However, the observed dependence of temperature on void size is in poor agreement with simulations, whereas the lensing results are consistent with ΛCDM theory. Thus, the overall tension between theory and observations does not favour non-standard theories of gravity, despite the hints of an enhanced amplitude for the ISW effect from voids.

  3. The growth and coalescence of ellipsoidal voids in plane strain under combined shear and tension

    Science.gov (United States)

    Scheyvaerts, F.; Onck, P. R.; Tekogˇlu, C.; Pardoen, T.

    2011-02-01

    New extensions of a model for the growth and coalescence of ellipsoidal voids based on the Gurson formalism are proposed in order to treat problems involving shear and/or voids axis not necessarily aligned with the main loading direction, under plane strain loading conditions. These extensions are motivated and validated using 3D finite element void cell calculations with overall plane strain enforced in one direction. The starting point is the Gologanu model dealing with spheroidal void shape. A void rotation law based on homogenization theory is coupled to this damage model. The predictions of the model closely agree with the 3D cell calculations, capturing the effect of the initial void shape and orientation on the void rotation rate. An empirical correction is also introduced for the change of the void aspect ratio in the plane transverse to the main axis of the void departing from its initially circular shape. This correction is needed for an accurate prediction of the onset of coalescence. Next, a new approach is proposed to take strain hardening into account within the Thomason criterion for internal necking, avoiding the use of strain hardening-dependent fitting parameters. The coalescence criterion is generalized to any possible direction of the coalescence plane and void orientation. Finally, the model is supplemented by a mathematical description of the final drop of the stress carrying capacity during coalescence. The entire model is developed for plane strain conditions, setting the path to a 3D extension. After validation of the model, a parametric study addresses the effect of shear on the ductility of metallic alloys for a range of microstructural and flow parameters, under different stress states. In general, the presence of shear, for identical stress triaxiality, decreases the ductility, partly explaining recent experimental results obtained in the low stress triaxiality regime.

  4. Effect of Rare Earth on Void Band of Diffusion Layer and Properties of Aluminized Steel

    Institute of Scientific and Technical Information of China (English)

    ZHANG Wei; FAN Zhi-kang; HU Peng-fei; LONG Yong-qiang; LIU Hua; WEN Jiu-ba

    2006-01-01

    The effects of the addition of rare earth (RE) elements on the void band in the diffusion layer, and the resistances to both oxidation and spalling of aluminized steel were investigated through high temperature oxidation and spalling tests. The results showed that RE had significant effects on the void band in the diffusion layer and the properties of aluminized steel. After diffusion treatment, a considerable number of the voids between the middle layer and transitional layer of pure aluminized coating, aggregated into wavy-line-shaped void bands parallel to the outer surface. For the RE-added aluminized coating, only a few voids aggregated into intermittent block shapes. During high temperature oxidation at 800 ℃ for 200 h, the wavy void band of pure aluminized coating aggregated further into a linear crack parallel to the outer surface, and the internal oxidation occurred within them; the open cracks perpendicular to the surface penetrated through the diffusion layer. For the RE-added aluminized coating, only a few voids aggregated into intermittent meniscus shapes. During cyclic spalling tests, the peeling, spallation, and pulverulent cracking occurred along the void band in the diffusion layer of pure aluminized coating, but only a little spallation occurred in the diffusion layer of the RE-added aluminized coating, in which cracks perpendicular to the surface were much smaller than those of pure aluminized coating and did not penetrate through the diffusion layer. It is evident that RE addition can restrain the formation and aggregation of voids and subsequently improve the resistances to oxidation and spalling. The mechanism of the RE effect on the void band in the diffusion layer is also discussed.

  5. 38 CFR 3.207 - Void or annulled marriage.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Void or annulled marriage... Void or annulled marriage. Proof that a marriage was void or has been annulled should consist of: (a... marriage void, together with such other evidence as may be required for a determination. (b) Annulled....

  6. Universal void density profiles from simulation and SDSS

    CERN Document Server

    Nadathur, S; Diego, J M; Iliev, I T; Gottlöber, S; Watson, W A; Yepes, G

    2014-01-01

    We discuss the universality and self-similarity of void density profiles, for voids in realistic mock luminous red galaxy (LRG) catalogues from the Jubilee simulation, as well as in void catalogues constructed from the SDSS LRG and Main Galaxy samples. Voids are identified using a modified version of the ZOBOV watershed transform algorithm, with additional selection cuts. We find that voids in simulation are self-similar, meaning that their average rescaled profile does not depend on the void size, or -- within the range of the simulated catalogue -- on the redshift. Comparison of the profiles obtained from simulated and real voids shows an excellent match. The profiles of real voids also show a universal behaviour over a wide range of galaxy luminosities, number densities and redshifts. This points to a fundamental property of the voids found by the watershed algorithm, which can be exploited in future studies of voids.

  7. Universal void density profiles from simulation and SDSS

    Science.gov (United States)

    Nadathur, S.; Hotchkiss, S.; Diego, J. M.; Iliev, I. T.; Gottlöber, S.; Watson, W. A.; Yepes, G.

    2016-10-01

    We discuss the universality and self-similarity of void density profiles, for voids in realistic mock luminous red galaxy (LRG) catalogues from the Jubilee simulation, as well as in void catalogues constructed from the SDSS LRG and Main Galaxy samples. Voids are identified using a modified version of the ZOBOV watershed transform algorithm, with additional selection cuts. We find that voids in simulation are self-similar, meaning that their average rescaled profile does not depend on the void size, or - within the range of the simulated catalogue - on the redshift. Comparison of the profiles obtained from simulated and real voids shows an excellent match. The profiles of real voids also show a universal behaviour over a wide range of galaxy luminosities, number densities and redshifts. This points to a fundamental property of the voids found by the watershed algorithm, which can be exploited in future studies of voids.

  8. Subclinical thyroid dysfunction and psychiatric disorders: cross-sectional results from the Brazilian Study of Adult Health (ELSA-Brasil).

    Science.gov (United States)

    Benseñor, Isabela M; Nunes, Maria Angélica; Sander Diniz, Maria de Fátima; Santos, Itamar S; Brunoni, André R; Lotufo, Paulo A

    2015-01-12

    To evaluate the association between subclinical thyroid dysfunction and psychiatric disorders using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Cross-sectional study. The study included 12 437 participants from the ELSA-Brasil with normal thyroid function (92·8%), 193 (1·4%) with subclinical hyperthyroidism and 784 (5·8%) with subclinical hypothyroidism, totalling 13 414 participants (50·6% of women). The mental health diagnoses of participants were assessed by trained raters using the Clinical Interview Schedule - Revised (CIS-R) and grouped according to the International Classification of Diseases 10 (ICD-10). Thyroid dysfunction was assessed using TSH and FT4 as well as routine use of thyroid hormones or antithyroid medications. Logistic models were presented using psychiatric disorders as the dependent variable and subclinical thyroid disorders as the independent variable. All logistic models were corrected for multiple comparisons using Bonferroni correction. After multivariate adjustment for possible confounders, we found a direct association between subclinical hyperthyroidism and panic disorder odds ratio [OR], 2·55; 95% confidence Interval (95% CI), 1·09-5·94; and an inverse association between subclinical hypothyroidism and generalized anxiety disorder (OR, 0·75; 95% CI, 0·59-0·96). However, both lost significance after correction for multiple comparisons. Subclinical hyperthyroidism was positively associated with panic disorder and negatively associated with anxiety disorder, although not significant after adjustment for multiple comparisons. © 2015 John Wiley & Sons Ltd.

  9. Microstructural characterization of XLPE electrical insulation in power cables: determination of void size distributions using TEM

    Science.gov (United States)

    Markey, L.; Stevens, G. C.

    2003-10-01

    In an effort to progress in our understanding of the ageing mechanisms of high voltage cables submitted to electrical and thermal stresses, we present a quantitative study of voids, the defects which are considered to be partly responsible for cable failure. We propose a method based on large data sets of transmission electron microscopy (TEM) observations of replicated samples allowing for the determination of void concentration distribution as a function of void size in the mesoscopic to microscopic range at any point in the cable insulation. A theory is also developed to calculate the effect of etching on the apparent size of the voids observed. We present the first results of this sort ever obtained on two industrial cables, one of which was aged in an AC field. Results clearly indicate that a much larger concentration of voids occur near the inner semiconductor compared to the bulk of the insulation, independently of ageing. An effect of ageing can also be seen near the inner semiconductor, resulting in an increase in the total void internal surface area and a slight shift of the concentration curve towards larger voids, with the peak moving from about 40 nm to about 50 nm.

  10. Effect of Void Size on the Detonation Pressure of Emulsion Explosives

    Science.gov (United States)

    Hirosaki, Yoshikazu; Murata, Kenji; Kato, Yukio; Itoh, Shigeru

    2002-07-01

    To study the effect of void size, detonation pressure as well as detonation velocity was measured using PVDF pressure gauge for the emulsion explosives sensitized with plastic balloons of five different size ranging from 0.05mm to 2.42mm. The experimental results were compared with the detonation pressure and velocity calculated using KHT code. The experimental results showed that the detonation pressure and velocity were strongly affected by void size, and that the fraction of ammonium nitrate reacted in the reaction zone was strongly dependent on void size.

  11. a New Algorithm for Void Filling in a Dsm from Stereo Satellite Images in Urban Areas

    Science.gov (United States)

    Gharib Bafghi, Z.; Tian, J.; d'Angelo, P.; Reinartz, P.

    2016-06-01

    Digital Surface Models (DSM) derived from stereo-pair satellite images are the main sources for many Geo-Informatics applications like 3D change detection, object classification and recognition. However since occlusion especially in urban scenes result in some deficiencies in the stereo matching phase, these DSMs contain some voids. In order to fill the voids a range of algorithms have been proposed, mainly including interpolation alone or along with auxiliary DSM. In this paper an algorithm for void filling in DSM from stereo satellite images has been developed. Unlike common previous approaches we didn't use any external DSM to fill the voids. Our proposed algorithm uses only the original images and the unfilled DSM itself. First a neighborhood around every void in the unfilled DSM and its corresponding area in multispectral image is defined. Then it is analysed to extract both spectral and geometric texture and accordingly to assign labels to each cell in the voids. This step contains three phases comprising shadow detection, height thresholding and image segmentation. Thus every cell in void has a label and is filled by the median value of its co-labelled neighbors. The results for datasets from WorldView-2 and IKONOS are shown and discussed.

  12. A NEW ALGORITHM FOR VOID FILLING IN A DSM FROM STEREO SATELLITE IMAGES IN URBAN AREAS

    Directory of Open Access Journals (Sweden)

    Z. Gharib Bafghi

    2016-06-01

    Full Text Available Digital Surface Models (DSM derived from stereo-pair satellite images are the main sources for many Geo-Informatics applications like 3D change detection, object classification and recognition. However since occlusion especially in urban scenes result in some deficiencies in the stereo matching phase, these DSMs contain some voids. In order to fill the voids a range of algorithms have been proposed, mainly including interpolation alone or along with auxiliary DSM. In this paper an algorithm for void filling in DSM from stereo satellite images has been developed. Unlike common previous approaches we didn’t use any external DSM to fill the voids. Our proposed algorithm uses only the original images and the unfilled DSM itself. First a neighborhood around every void in the unfilled DSM and its corresponding area in multispectral image is defined. Then it is analysed to extract both spectral and geometric texture and accordingly to assign labels to each cell in the voids. This step contains three phases comprising shadow detection, height thresholding and image segmentation. Thus every cell in void has a label and is filled by the median value of its co-labelled neighbors. The results for datasets from WorldView-2 and IKONOS are shown and discussed.

  13. Frequency of sexual dysfunction and other reproductive side-effects in patients with schizophrenia treated with risperidone, olanzapine, quetiapine, or haloperidol: the results of the EIRE study.

    Science.gov (United States)

    Bobes, J; Garc A-Portilla, M P; Rejas, J; Hern Ndez, G; Garcia-Garcia, M; Rico-Villademoros, F; Porras, A

    2003-01-01

    Atypical antipsychotics seem to differ mainly in their tolerability profile. The aim of this cross-sectional study, the Estudio de Investigaci n de Resultados en Esquizofrenia (Outcomes Research Study in Schizophrenia; EIRE study), was to assess in a clinical setting the frequency of several side-effects related to haloperidol, risperidone, olanzapine, and quetiapine. This article addresses sexual dysfunction and other reproductive side-effects (gynecomastia, menorrhage, amenorrhea, and galactorrhea). We recruited outpatients diagnosed with schizophrenia according to Diagnostic and Statistical Manual of Mental Disorders (DSM-IV; American Psychiatric Association, 1994) criteria and who had received a single antipsychotic (risperidone, olanzapine, quetiapine, or haloperidol) for at least 4 weeks. During a single visit, we collected data, including demographic and clinical characteristics, current antipsychotic and concomitant treatment, and adverse effects listed in a modified version of the UKU Scale. We used a Chi-squared test to determine pairs comparisons of the frequency of adverse reactions between treatments. To estimate risk of a given adverse reaction with a given treatment, we used a logistic regression method. We assessed 636 evaluable patients out of 669 recruited. Frequency of sexual dysfunction was high with haloperidol (38.1%) and also with olanzapine (35.3%), quetiapine (18.2%), and risperidone (43.2%). We found the frequency of other reproductive side-effects to be relatively low with all four drugs: haloperidol (6.9%), olanzapine (6.4%), quetiapine (2.7%), and risperidone (11.7%). Sexual dysfunction appeared to be dose-related with haloperidol, risperidone, and olanzapine. Risperidone and olanzapine showed a higher risk of sexual dysfunction and other reproductive sideeffects than haloperidol. Quetiapine showed a lower risk of sexual dysfunction during short-term treatment ( 12 weeks) are lacking. Our results suggest that none of the atypical

  14. Radionuclide voiding cystography in intrarenal reflux detection

    Energy Technology Data Exchange (ETDEWEB)

    Rizzoni, G.; Perale, R.; Bui, F.; Pitter, M.; Pavanello, L.; Boscolo, R.; Passerini Glazel, G.; Macri, C.

    1986-01-01

    In order to evaluate the possibility of detecting intra-renal reflux (IRR) with a more sensitive procedure, 48 children with recurrent urinary tract infections underwent intravenous urography (IVU) and voiding cystourethrogram (VCU) using a solution containing contrast medium and sup(99m)Tc-sulfur colloid particles which are known to persist in the renal parenchyma for a long time. Scintigraphic images were taken at 5 and 20 hours after VCU. 18 children had no vesico-ureteral reflux, 11 showed unilateral and 19 bilateral VUR, which was therefore present in 49 renal units. Among the 49 renal refluxing units (RRUs) IRR was detected radiologically in 8; of these isotopic activity in the renal area was present in all 6 RRUs who were examined at 20 hours. Of the remaining 41 RRUs with no radiologically detectable IRR 24 were evaluated at 20 hours and 5 (21%) showed renal radioactivity. Renal scars were significantly more frequent in kidneys with radioisotopic activity at 20 hours. The results of this study indicate that radionuclide cystography using sup(99m)Tc-sulfur colloid is a reliable procedure for demonstrating IRR, and to this end is more sensitive than X-ray VCU. Radionuclide cystography with sulfur colloid particles should therefore be considered a simple and useful complementary procedure, which is more sensitive than X-ray VCU in the diagnosis and follow-up of IRR.

  15. A New Void Fraction Measurement Method for Gas-Liquid Two-Phase Flow in Small Channels

    OpenAIRE

    Huajun Li; Haifeng Ji; Zhiyao Huang; Baoliang Wang; Haiqing Li; Guohua Wu

    2016-01-01

    Based on a laser diode, a 12 × 6 photodiode array sensor, and machine learning techniques, a new void fraction measurement method for gas-liquid two-phase flow in small channels is proposed. To overcome the influence of flow pattern on the void fraction measurement, the flow pattern of the two-phase flow is firstly identified by Fisher Discriminant Analysis (FDA). Then, according to the identification result, a relevant void fraction measurement model which is developed by Support Vector Mach...

  16. Cosmic Voids: structure, dynamics and galaxies

    CERN Document Server

    van de Weygaert, Rien

    2009-01-01

    In this review we discuss several aspects of Cosmic Voids. Voids are a major component of the large scale distribution of matter and galaxies in the Universe. They are of instrumental importance for understanding the emergence of the Cosmic Web. Their relatively simple shape and structure makes them into useful tools for extracting the value of a variety cosmic parameters, possibly including even that of the influence of dark energy. Perhaps most promising and challenging is the issue of the galaxies found within their realm. Not only does the pristine environment of voids provide a promising testing ground for assessing the role of environment on the formation and evolution of galaxies, the dearth of dwarf galaxies may even represent a serious challenge to the standard view of cosmic structure formation.

  17. Void coalescence within periodic clusters of particles

    Science.gov (United States)

    Thomson, C. I. A.; Worswick, M. J.; Pilkey, A. K.; Lloyd, D. J.

    2003-01-01

    The effect of particle clustering on void damage rates in a ductile material under triaxial loading conditions is examined using three-dimensional finite element analysis. An infinite material containing a regular distribution of clustered particles is modelled using a unit cell approach. Three discrete particles are introduced into each unit cell while a secondary population of small particles within the surrounding matrix is represented using the Gurson-Tvergaard-Needleman (GTN) constitutive equations. Deformation strain states characteristic of sheet metal forming are considered; that is, deep drawing, plane strain and biaxial stretching. Uniaxial tensile stress states with varying levels of superimposed hydrostatic tension are also examined. The orientation of a particle cluster with respect to the direction of major principal loading is shown to significantly influence failure strains. Coalescence of voids within a first-order particle cluster (consisting of three particles) is a stable event while collapse of inter-cluster ligaments leads to imminent material collapse through void-sheeting.

  18. Integrative deficits in depression and in negative mood states as a result of fronto-parietal network dysfunctions.

    Science.gov (United States)

    Brzezicka, Aneta

    2013-01-01

    Depression is a disorder characterized not only by persistent negative mood, lack of motivation and a "ruminative" style of thinking, but also by specific deficits in cognitive functioning. These deficits are especially pronounced when integration of information is required. Previous research on linear syllogisms points to a clear pattern of cognitive disturbances present in people suffering from depressive disorders, as well as in people with elevated negative mood. Such disturbances are characterized by deficits in the integration of piecemeal information into coherent mental representations. In this review, I present evidence which suggests that the dysfunction of specific brain areas plays a crucial role in creating reasoning and information integration problems among people with depression and with heightened negative mood. As the increasingly prevalent systems neuroscience approach is spreading into the study of mental disorders, it is important to understand how and which brain networks are involved in creating certain symptoms of depression. Two large brain networks are of particular interest when considering depression: the default mode network (DMN) and the fronto-parietal (executive) network (FNP). The DMN network shows abnormally high activity in the depressed population, whereas FNP circuit activity is diminished. Disturbances within the FNP network seem to be strongly associated with cognitive problems in depression, especially those concerning executive functions. The dysfunctions within the fronto-parietal network are most probably connected to ineffective transmission of information between prefrontal and parietal regions, and also to an imbalance between FNP and DMN circuits. Inefficiency of this crucial circuits functioning may be a more general mechanism leading to problems with flexible cognition and executive functions, and could be the cause of more typical symptoms of depression like persistent rumination.

  19. Malposition of catheters during voiding cystourethrography

    Energy Technology Data Exchange (ETDEWEB)

    Rathaus, V.; Konen, O.; Shapiro, M. [Dept. of Diagnostic Imaging Sapir Medical Center, Kfar-Saba and Sackler Medical School, Tel Aviv University (Israel); Grunebaum, M. [Veteran Pediatric Radiologist, Kfar Saba (Israel)

    2001-04-01

    The aim of this study was to report catheter malposition during voiding cystourethrography. Eight hundred forty-three voiding cystourethrography (265 males and 578 females, aged 1 week to 12 years, mean age 2 years) were performed during a period of 4 years. The conventional standard procedure was applied. In 3 cases with passed history of urinary tract infection the catheter entered directly into the ureter. In all these cases the uretero-vesical reflux was present on the same side where the catheter entered. It appears that insertion of a catheter into the ureter is possible only in the presence of an anomaly or pathology at the vesicoureteric junction. (orig.)

  20. Plasticity size effects in voided crystals

    DEFF Research Database (Denmark)

    Hussein, M. I.; Borg, Ulrik; Niordson, Christian Frithiof;

    The shear and equi-biaxial straining responses of periodic voided single crystals are analysed using discrete dislocation plasticity and a continuum strain gradient crystal plasticity theory. In the discrete dislocation formulation the dislocations are all of edge character and are modelled as line...... predictions of the two formulations for all crystal types and void volume fractions considered when the material length scale in the non-local plasticity model chosen to be $0.325\\mu m$ (around ten times the slip plane spacing in the discrete dislocation models)....

  1. Estimation of the Void Fraction in the moderator cell of the Cold Neutron Source

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Jungwoon; Kim, Young-ki [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    To estimate the average void fraction in the liquid hydrogen, the Kazimi and Chen correlation is used with its modified method suggested by R.E. Williams in NBSR. Since the multiplying number can be changed along the operation condition and working fluid, the different figure is applied to estimate the average void fraction in the different moderator cell shape. This approach is checked with the void fraction measurement results from the HANARO-CNS mock-up test. Owing to national research demands on cold neutron beam utilization, the Cold Neutron Research Facility had been and operated for neuron scientists all over the world. In HANARO, the CNS facility has been operated since 2009. The actual void fraction, which is the one of dominant factors affecting the cold neutron flux, is difficult to know without the real measurement performed at the cryogenic temperature using the same moderator medium. Accordingly, the two-phase mock-up test in the CNS-IPA (In-pool assembly) had been performed using the liquid hydrogen in terms of the fluidity check, void fraction measurement, operation procedure set-up, and so on for the development of the HANARO-CNS. This paper presents the estimated void fraction in the different operating conditions and geometrical shape in the comparison with the measurement data of the void fraction in the full-scale mockup test based on the Kazimi and Chen correlation. This approach is applied to estimate the average void fraction in the newly designed moderator cell using the liquid hydrogen as a working fluid in the two-phase thermosiphon. From this calculation result, the estimated average void fraction will be used to design the optimized cold neutron source to produce the maximum cold neutron flux within the desired wavelength.

  2. DIVE in the cosmic web: voids with Delaunay triangulation from discrete matter tracer distributions

    Science.gov (United States)

    Zhao, Cheng; Tao, Charling; Liang, Yu; Kitaura, Francisco-Shu; Chuang, Chia-Hsun

    2016-07-01

    We present a novel parameter-free cosmological void finder (DIVE, Delaunay TrIangulation Void findEr) based on Delaunay Triangulation (DT), which efficiently computes the empty spheres constrained by a discrete set of tracers. We define the spheres as DT voids, and describe their properties, including a universal density profile together with an intrinsic scatter. We apply this technique on 100 halo catalogues with volumes of 2.5 h-1Gpc side each, with a bias and number density similar to the Baryon Oscillation Spectroscopic Survey CMASS luminous red galaxies, performed with the PATCHY code. Our results show that there are two main species of DT voids, which can be characterized by the radius: they have different responses to halo redshift space distortions, to number density of tracers, and reside in different dark matter environments. Based on dynamical arguments using the tidal field tensor, we demonstrate that large DT voids are hosted in expanding regions, whereas the haloes used to construct them reside in collapsing ones. Our approach is therefore able to efficiently determine the troughs of the density field from galaxy surveys, and can be used to study their clustering. We further study the power spectra of DT voids, and find that the bias of the two populations are different, demonstrating that the small DT voids are essentially tracers of groups of haloes.

  3. Influence of Grain Boundary Character on Creep Void Formation in Alloy 617

    Science.gov (United States)

    Lillo, Thomas; Cole, James; Frary, Megan; Schlegel, Scott

    2009-12-01

    Alloy 617, a high-temperature creep-resistant, nickel-based alloy, is being considered for the primary heat exchanger for the Next Generation Nuclear Plant (NGNP), which will operate at temperatures exceeding 760 °C and a helium pressure of approximately 7 MPa. Observations of the crept microstructure using optical microscopy indicate creep stress does not significantly influence the creep void fraction at a given creep strain over the relatively narrow set of creep conditions studied. Void formation was found to occur only after significant creep in the tertiary regime (>5 pct total creep strain) had occurred. Also, orientation imaging microscopy (OIM) was used to characterize the grain boundaries in the vicinity of creep voids that develop during high-temperature creep tests (900 °C to 1000 °C at creep stresses ranging from 20 to 40 MPa) terminated at creep strains ranging from 5 to 40 pct. Preliminary analysis of the OIM data indicates voids tend to form on grain boundaries parallel, perpendicular, or 45 deg to the tensile axis, while few voids are found at intermediate inclinations to the tensile axis. Random grain boundaries intersect most voids, while coincident site lattice (CSL)-related grain boundaries did not appear to be consistently associated with void development. Similar results were found in oxygen-free, high-conductivity (OFHC) copper, severely deformed using equal channel angular extrusion, and creep tested at 450 °C and 14 MPa.

  4. A New Void Fraction Measurement Method for Gas-Liquid Two-Phase Flow in Small Channels.

    Science.gov (United States)

    Li, Huajun; Ji, Haifeng; Huang, Zhiyao; Wang, Baoliang; Li, Haiqing; Wu, Guohua

    2016-01-27

    Based on a laser diode, a 12 × 6 photodiode array sensor, and machine learning techniques, a new void fraction measurement method for gas-liquid two-phase flow in small channels is proposed. To overcome the influence of flow pattern on the void fraction measurement, the flow pattern of the two-phase flow is firstly identified by Fisher Discriminant Analysis (FDA). Then, according to the identification result, a relevant void fraction measurement model which is developed by Support Vector Machine (SVM) is selected to implement the void fraction measurement. A void fraction measurement system for the two-phase flow is developed and experiments are carried out in four different small channels. Four typical flow patterns (including bubble flow, slug flow, stratified flow and annular flow) are investigated. The experimental results show that the development of the measurement system is successful. The proposed void fraction measurement method is effective and the void fraction measurement accuracy is satisfactory. Compared with the conventional laser measurement systems using standard laser sources, the developed measurement system has the advantages of low cost and simple structure. Compared with the conventional void fraction measurement methods, the proposed method overcomes the influence of flow pattern on the void fraction measurement. This work also provides a good example of using low-cost laser diode as a competent replacement of the expensive standard laser source and hence implementing the parameter measurement of gas-liquid two-phase flow. The research results can be a useful reference for other researchers' works.

  5. Crystal-Orientation Dependent Evolution of Edge Dislocations from a Void in Single Crystal Gu

    Institute of Scientific and Technical Information of China (English)

    SONG Zhen-Fei; ZHU Wen-Jun; DENG Xiao-Liang; HE Hong-Liang

    2006-01-01

    @@ The micro-void growth by dislocation emission under tensile loading is explored with focus on the influence of crystal orientations. Based on the elastic theory, a dislocation emission criterion is formulated. It is predicted that the preferential location of dislocation nucleation and its threshold stress are dependent on the crystal orientation.Large-scale molecular dynamics (MD) simulations are also performed for single crystal copper to illustrate the dislocation evolution pattern associated with a nano-void growth. The results are in line with those given by the theoretical prediction. As revealed by MD simulations, the characteristics of void growth at micro-scale depend greatly on the crystal-orientation.

  6. Partial discharge patterns related to surface deterioration in voids in epoxy

    DEFF Research Database (Denmark)

    Holbøll, Joachim; Henriksen, Mogens

    1990-01-01

    Results are presented from an investigation of the relationship between changes in partial discharge patterns and the surface deterioration process taking place in small naturally formed spherical voids in epoxy plastic. The voids were exposed to a moderate electric stress above inception level......, where partial discharges were present for more than 1500 h. Two types of electrical tree growth were found, the bush like tree and a single channel-like tree, which led to very different partial discharge patterns. It is concluded that the formation of crystals on a void surface leads to an immediate...

  7. Study of localization in a void-sheet under stress states near pure shear

    DEFF Research Database (Denmark)

    Tvergaard, Viggo

    2015-01-01

    to the principal tensile stress. A number of previous investigations have shown that such imperfections can lead to plastic flow localization in a shear band and subsequently lead to void-sheet fracture inside the band. The present analyses confirm that the imperfection results in localization failure, even......-cracks. For the largest imperfection considered, i.e. a relatively large ratio of the void radius to void spacing, there is still a range of stress states in the vicinity of pure shear, where no localization is predicted, and for smaller imperfections this range is larger....

  8. Attention Deficit-Hyperactivity Disorder Symptoms and Daytime Voiding Symptoms in Children with Primary Enuresis: An Observational Study to Evaluate the Effectiveness of Desmopressin Treatment

    Directory of Open Access Journals (Sweden)

    Teng-Kai Yang

    2015-01-01

    Full Text Available Purpose. To evaluate the effectiveness of presence of desmopressin in treating primary enuresis (PE for children with attention deficit-hyperactivity disorder (ADHD symptoms. Materials and Methods. Children aged from 5 to 12 years with the chief complaint of PE treated with desmopressin were enrolled in pediatric urology clinics. The parent-reported SNAP-IV questionnaire was used to evaluate ADHD symptoms (cut-off value: 90th percentile. Voiding symptoms were assessed by the Dysfunctional Voiding Scoring System (DVSS questionnaire. The responses to desmopressin were analyzed in children with and without ADHD symptoms. Results. The study sample comprised 68 children; 27 (39.7% presented with ADHD symptoms and 41 (60.3% with non-ADHD symptoms. The children collected from a tertiary referral center may explain the high prevalence of ADHD symptoms in the present study. The total DVSS score in the ADHD symptoms group was significantly higher than in the non-ADHD symptoms group (7.72 versus 5.65, P=0.05. In the ADHD symptoms group, there were significantly higher score in the “pee 1-2 times/day” and “can’t wait” subscales of DVSS and lower sleep quality based on the Pediatric Sleep Quality questionnaire, as well as significantly lower peak flow rate and voided volume. The responses to desmopressin for enuresis were comparable between children with ADHD and non-ADHD symptoms. Conclusions. Approximately 39.7% of PE children presented with ADHD symptoms at urologic clinics. PE children with ADHD symptoms had higher risk of daytime LUTS and comparable response to desmopressin treatment for PE. To evaluate ADHD symptoms and daytime voiding symptoms is important in children with PE.

  9. The ISW imprints of voids and superclusters on the CMB

    Science.gov (United States)

    Hotchkiss, S.; Nadathur, S.; Gottlöber, S.; Iliev, I. T.; Knebe, A.; Watson, W. A.; Yepes, G.

    2016-10-01

    We examine the stacked integrated Sachs-Wolfe (ISW) imprints on the CMB along the lines of sight of voids and superclusters in galaxy surveys, using the Jubilee ISW simulation and mock luminous red galaxy (LRG) catalogues. We show that the expected signal in the concordance \\Lam CDM model is much smaller than the primary anisotropies arising at the last scattering surface and therefore any currently claimed detections of such an imprint cannot be caused by the ISW effect in \\Lam CDM. We look for the existence of such a signal in the Planck CMB using a catalogue of voids and superclusters from the Sloan Digital Sky Survey (SDSS), but find a result completely consistent with \\Lam CDM - i.e., a null detection.

  10. Study on voids of epoxy matrix composites sandwich structure parts

    Science.gov (United States)

    He, Simin; Wen, Youyi; Yu, Wenjun; Liu, Hong; Yue, Cheng; Bao, Jing

    2017-03-01

    Void is the most common tiny defect of composite materials. Porosity is closely related to composite structure property. The voids forming behaviour in the composites sandwich structural parts with the carbon fiber reinforced epoxy resin skins was researched by adjusting the manufacturing process parameters. The composites laminate with different porosities were prepared with the different process parameter. The ultrasonic non-destructive measurement method for the porosity was developed and verified through microscopic examination. The analysis results show that compaction pressure during the manufacturing process had influence on the porosity in the laminate area. Increasing the compaction pressure and compaction time will reduce the porosity of the laminates. The bond-line between honeycomb core and carbon fiber reinforced epoxy resin skins were also analyzed through microscopic examination. The mechanical properties of sandwich structure composites were studied. The optimization process parameters and porosity ultrasonic measurement method for composites sandwich structure have been applied to the production of the composite parts.

  11. Cosmic Voids and Void Lensing in the Dark Energy Survey Science Verification Data

    CERN Document Server

    Sánchez, C; Kovacs, A; Jain, B; García-Bellido, J; Nadathur, S; Gruen, D; Hamaus, N; Huterer, D; Vielzeuf, P; Amara, A; Bonnett, C; DeRose, J; Hartley, W G; Jarvis, M; Lahav, O; Miquel, R; Rozo, E; Rykoff, E S; Sheldon, E; Wechsler, R H; Zuntz, J; Abbott, T M C; Abdalla, F B; Annis, J; Benoit-Lévy, A; Bernstein, G M; Bernstein, R A; Bertin, E; Brooks, D; Buckley-Geer, E; Rosell, A Carnero; Kind, M Carrasco; Carretero, J; Crocce, M; Cunha, C E; D'Andrea, C B; da Costa, L N; Desai, S; Diehl, H T; Dietrich, J P; Doel, P; Evrard, A E; Neto, A Fausti; Flaugher, B; Fosalba, P; Frieman, J; Gaztanaga, E; Gruendl, R A; Gutierrez, G; Honscheid, K; James, D J; Krause, E; Kuehn, K; Lima, M; Maia, M A G; Marshall, J L; Melchior, P; Plazas, A A; Reil, K; Romer, A K; Sanchez, E; Schubnell, M; Sevilla-Noarbe, I; Smith, R C; Soares-Santos, M; Sobreira, F; Suchyta, E; Tarle, G; Thomas, D; Walker, A R; Weller, J

    2016-01-01

    Galaxies and their dark matter halos populate a complicated filamentary network around large, nearly empty regions known as cosmic voids. Cosmic voids are usually identified in spectroscopic galaxy surveys, where 3D information about the large-scale structure of the Universe is available. Although an increasing amount of photometric data is being produced, its potential for void studies is limited since photometric redshifts induce line-of-sight position errors of $\\sim50$ Mpc/$h$ or more that can render many voids undetectable. In this paper we present a new void finder designed for photometric surveys, validate it using simulations, and apply it to the high-quality photo-$z$ redMaGiC galaxy sample of the Dark Energy Survey Science Verification (DES-SV) data. The algorithm works by projecting galaxies into 2D slices and finding voids in the smoothed 2D galaxy density field of the slice. Fixing the line-of-sight size of the slices to be at least twice the photo-$z$ scatter, the number of voids found in these ...

  12. Thermal stress induced voids in nanoscale copper interconnects by in-situ TEM heating

    Science.gov (United States)

    An, Jin Ho

    Stress induced void formation in Cu interconnects, due to thermal stresses generated during the processing of semiconductors, is an increasing reliability issue in the semiconductor industry as Cu interconnects are being downscaled to follow the demand for faster chip speed. In this work, 1.8 micron and 180 nm wide Cu interconnects, fabricated by Freescale Semiconductors, were subjected to thermal cycles, in-situ in the TEM, to investigate the stress relaxation mechanisms as a function of interconnect linewidth. The experiments show that the 1.8 micron Cu interconnect lines relax the thermal stresses through dislocation nucleation and motion while the Cu interconnect 180 nm lines exhibit void formation. Void formation in 180 nm lines occurs predominantly at triple junctions where the Ta diffusion barrier meets a Cu grain boundary. In order to understand void formation in 180 nm lines, the grain orientation and local stresses are determined. In particular, Nanobeam Diffraction (NBD) in the TEM is used to obtain the diffraction pattern of each grain, from which the crystal orientation is evaluated by the ACT (Automated Crystallography for TEM) software. In addition, 2D Finite Element Method (FEM) simulations are performed using the Object Oriented Finite Modeling (OOF2) software to correlate grain orientation with local stresses, and consequently void formation. According to the experimental and simulation results obtained, void formation in 180nm Cu interconnects does not seem to be solely dependent on local stresses, but a combination of diffusion paths available, stress gradients and possibly the presence of defects. In addition, based on the in-situ TEM observations, void growth seems to occur through grain boundary and/or interfacial diffusion. However, in-situ STEM observations of fully opened voids post-failure show pileup of material at the Cu grain surfaces. This means that surface or interface diffusion is also very active during void growth in the presence

  13. Validation uncertainty of MATRA code for subchannel void distributions

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Dae-Hyun; Kim, S. J.; Kwon, H.; Seo, K. W. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    To extend code capability to the whole core subchannel analysis, pre-conditioned Krylov matrix solvers such as BiCGSTAB and GMRES are implemented in MATRA code as well as parallel computing algorithms using MPI and OPENMP. It is coded by fortran 90, and has some user friendly features such as graphic user interface. MATRA code was approved by Korean regulation body for design calculation of integral-type PWR named SMART. The major role subchannel code is to evaluate core thermal margin through the hot channel analysis and uncertainty evaluation for CHF predictions. In addition, it is potentially used for the best estimation of core thermal hydraulic field by incorporating into multiphysics and/or multi-scale code systems. In this study we examined a validation process for the subchannel code MATRA specifically in the prediction of subchannel void distributions. The primary objective of validation is to estimate a range within which the simulation modeling error lies. The experimental data for subchannel void distributions at steady state and transient conditions was provided on the framework of OECD/NEA UAM benchmark program. The validation uncertainty of MATRA code was evaluated for a specific experimental condition by comparing the simulation result and experimental data. A validation process should be preceded by code and solution verification. However, quantification of verification uncertainty was not addressed in this study. The validation uncertainty of the MATRA code for predicting subchannel void distribution was evaluated for a single data point of void fraction measurement at a 5x5 PWR test bundle on the framework of OECD UAM benchmark program. The validation standard uncertainties were evaluated as 4.2%, 3.9%, and 2.8% with the Monte-Carlo approach at the axial levels of 2216 mm, 2669 mm, and 3177 mm, respectively. The sensitivity coefficient approach revealed similar results of uncertainties but did not account for the nonlinear effects on the

  14. Hypothalamic dysfunction

    Science.gov (United States)

    ... common causes of hypothalamic dysfunction are surgery, traumatic brain injury, tumors, and radiation. Other causes include: Anorexia nervosa or bulimia Bleeding Genetic disorders that cause iron ...

  15. Oxygen glucose deprivation in rat hippocampal slice cultures results in alterations in carnitine homeostasis and mitochondrial dysfunction.

    Directory of Open Access Journals (Sweden)

    Thomas F Rau

    Full Text Available Mitochondrial dysfunction characterized by depolarization of mitochondrial membranes and the initiation of mitochondrial-mediated apoptosis are pathological responses to hypoxia-ischemia (HI in the neonatal brain. Carnitine metabolism directly supports mitochondrial metabolism by shuttling long chain fatty acids across the inner mitochondrial membrane for beta-oxidation. Our previous studies have shown that HI disrupts carnitine homeostasis in neonatal rats and that L-carnitine can be neuroprotective. Thus, this study was undertaken to elucidate the molecular mechanisms by which HI alters carnitine metabolism and to begin to elucidate the mechanism underlying the neuroprotective effect of L-carnitine (LCAR supplementation. Utilizing neonatal rat hippocampal slice cultures we found that oxygen glucose deprivation (OGD decreased the levels of free carnitines (FC and increased the acylcarnitine (AC: FC ratio. These changes in carnitine homeostasis correlated with decreases in the protein levels of carnitine palmitoyl transferase (CPT 1 and 2. LCAR supplementation prevented the decrease in CPT1 and CPT2, enhanced both FC and the AC∶FC ratio and increased slice culture metabolic viability, the mitochondrial membrane potential prior to OGD and prevented the subsequent loss of neurons during later stages of reperfusion through a reduction in apoptotic cell death. Finally, we found that LCAR supplementation preserved the structural integrity and synaptic transmission within the hippocampus after OGD. Thus, we conclude that LCAR supplementation preserves the key enzymes responsible for maintaining carnitine homeostasis and preserves both cell viability and synaptic transmission after OGD.

  16. Measurement of post-void residual urine

    NARCIS (Netherlands)

    Asimakopoulos, Anastasios D.; De Nunzio, Cosimo; Kocjancic, Ervin; Tubaro, Andrea; Rosier, Peter F.; Finazzi-Agrò, Enrico

    2016-01-01

    Aims To present the teaching module "Measurement of Post-void residual urine." Methods This module has been prepared by a Working Group of the ICS Urodynamics Committee. The methodology used included comprehensive literature review, consensus formation by the members of the Working Group, and review

  17. Void fraction instrument acceptance test procedure

    Energy Technology Data Exchange (ETDEWEB)

    Pearce, K.L.

    1994-09-15

    This acceptance test procedure (ATP) was written to test the void fraction instrument (VFI) and verify that the unit is ready for field service. The procedure verifies that the mechanical and electrical features (not specifically addressed in the software ATP) and software alarms are operating as designed.

  18. Halo abundances and shear in void models

    DEFF Research Database (Denmark)

    Alonso, David; García-Bellido, Juan; Haugbølle, Troels

    2012-01-01

    We study the non-linear gravitational collapse of dark matter into halos through numerical N-body simulations of Lemaitre-Tolman-Bondi void models. We extend the halo mass function formalism to these models in a consistent way. This extension not only compares well with the simulated data at all ...

  19. Halo abundances and shear in void models

    DEFF Research Database (Denmark)

    Alonso, David; García-Bellido, Juan; Haugbølle, Troels;

    2012-01-01

    We study the non-linear gravitational collapse of dark matter into halos through numerical N-body simulations of Lemaitre-Tolman-Bondi void models. We extend the halo mass function formalism to these models in a consistent way. This extension not only compares well with the simulated data at all...

  20. Void fraction instrument acceptance test procedure

    Energy Technology Data Exchange (ETDEWEB)

    Pearce, K.L.

    1994-09-15

    This acceptance test procedure (ATP) was written to test the void fraction instrument (VFI) and verify that the unit is ready for field service. The procedure verifies that the mechanical and electrical features (not specifically addressed in the software ATP) and software alarms are operating as designed.

  1. "Dark energy" in the Local Void

    Science.gov (United States)

    Villata, M.

    2012-05-01

    The unexpected discovery of the accelerated cosmic expansion in 1998 has filled the Universe with the embarrassing presence of an unidentified "dark energy", or cosmological constant, devoid of any physical meaning. While this standard cosmology seems to work well at the global level, improved knowledge of the kinematics and other properties of our extragalactic neighborhood indicates the need for a better theory. We investigate whether the recently suggested repulsive-gravity scenario can account for some of the features that are unexplained by the standard model. Through simple dynamical considerations, we find that the Local Void could host an amount of antimatter (˜5×1015 M ⊙) roughly equivalent to the mass of a typical supercluster, thus restoring the matter-antimatter symmetry. The antigravity field produced by this "dark repulsor" can explain the anomalous motion of the Local Sheet away from the Local Void, as well as several other properties of nearby galaxies that seem to require void evacuation and structure formation much faster than expected from the standard model. At the global cosmological level, gravitational repulsion from antimatter hidden in voids can provide more than enough potential energy to drive both the cosmic expansion and its acceleration, with no need for an initial "explosion" and dark energy. Moreover, the discrete distribution of these dark repulsors, in contrast to the uniformly permeating dark energy, can also explain dark flows and other recently observed excessive inhomogeneities and anisotropies of the Universe.

  2. The Metallicity of Void Dwarf Galaxies

    NARCIS (Netherlands)

    Kreckel, K.; Croxall, K.; Groves, B.; van de Weygaert, R.; Pogge, R. W.

    2015-01-01

    The current ΛCDM cosmological model predicts that galaxy evolution proceeds more slowly in lower density environments, suggesting that voids are a prime location to search for relatively pristine galaxies that are representative of the building blocks of early massive galaxies. To test the assumptio

  3. Partial discharges in ellipsoidal and spheroidal voids

    DEFF Research Database (Denmark)

    Crichton, George C; Karlsson, P. W.; Pedersen, Aage

    1989-01-01

    Transients associated with partial discharges in voids can be described in terms of the charges induced on the terminal electrodes of the system. The relationship between the induced charge and the properties which are usually measured is discussed. The method is illustrated by applying it to a s...

  4. Atomistic modeling of shock-induced void collapse in copper

    Energy Technology Data Exchange (ETDEWEB)

    Davila, L P; Erhart, P; Bringa, E M; Meyers, M A; Lubarda, V A; Schneider, M S; Becker, R; Kumar, M

    2005-03-09

    Nonequilibrium molecular dynamics (MD) simulations show that shock-induced void collapse in copper occurs by emission of shear loops. These loops carry away the vacancies which comprise the void. The growth of the loops continues even after they collide and form sessile junctions, creating a hardened region around the collapsing void. The scenario seen in our simulations differs from current models that assume that prismatic loop emission is responsible for void collapse. We propose a new dislocation-based model that gives excellent agreement with the stress threshold found in the MD simulations for void collapse as a function of void radius.

  5. Multipole analysis of redshift-space distortions around cosmic voids

    Science.gov (United States)

    Hamaus, Nico; Cousinou, Marie-Claude; Pisani, Alice; Aubert, Marie; Escoffier, Stéphanie; Weller, Jochen

    2017-07-01

    We perform a comprehensive redshift-space distortion analysis based on cosmic voids in the large-scale distribution of galaxies observed with the Sloan Digital Sky Survey. To this end, we measure multipoles of the void-galaxy cross-correlation function and compare them with standard model predictions in cosmology. Merely considering linear-order theory allows us to accurately describe the data on the entire available range of scales and to probe void-centric distances down to about 2 h-1Mpc. Common systematics, such as the Fingers-of-God effect, scale-dependent galaxy bias, and nonlinear clustering do not seem to play a significant role in our analysis. We constrain the growth rate of structure via the redshift-space distortion parameter β at two median redshifts, β(bar z=0.32)=0.599+0.134-0.124 and β(bar z=0.54)=0.457+0.056-0.054, with a precision that is competitive with state-of-the-art galaxy-clustering results. While the high-redshift constraint perfectly agrees with model expectations, we observe a mild 2σ deviation at bar z=0.32, which increases to 3σ when the data is restricted to the lowest available redshift range of 0.15

  6. Piezoelectric performance of fluor polymer sandwiches with different void structures

    Science.gov (United States)

    Lou, Kexing; Zhang, Xiaoqing; Xia, Zhongfu

    2012-06-01

    Film sandwiches, consisting of two outer layers of fluoroethylenepropylene and one middle layer of patterned porous polytetrafluoroethylene, were prepared by patterning and fusion bonding. Contact charging was conducted to render the films piezoelectric. The critical voltage to trigger air breakdown in the inner voids in the fabricated films was investigated. The piezoelectric d 33 coefficients were measured employing the quasistatic method and dielectric resonance spectrum. The results show that the critical voltage for air breakdown in the inner voids is associated with the void microstructure of the films. For the films with patterning factors of 0%, 25% and 44%, the critical values are 300, 230 and 230 kV/cm, respectively. With an increase in the patterning factor, both the piezoelectric d 33 coefficients determined from the dielectric resonance spectra and those determined from quasistatic measurements increase, which might be due to a decrease in Young's modulus for the films. The nonlinearity of d 33 becomes increasingly obvious as the patterning factor increases.

  7. Pulsed electrical breakdown of a void-filled dielectric

    Science.gov (United States)

    Anderson, R. A.; Lagasse, R. R.; Schroeder, J. L.

    2002-05-01

    We report breakdown strengths in a void-filled dielectric material, epoxy containing 48 vol % hollow glass microballoon filler, which is stressed with unipolar voltage pulses of the order of 10 μs duration. The microballoon voids had mean diameters of approximately 40 μm and contained SO2 gas at roughly 30% atmospheric pressure. This void-filled material displays good dielectric strength (of the order of 100 kV mm-1) under these short-pulse test conditions. Results from a variety of electrode geometries are reported, including arrangements in which the electric stress is highly nonuniform. Conventional breakdown criteria based on mean or peak electric stress do not account for these data. A statistics-based predictive breakdown model is developed, in which the dielectric is divided into independent, microballoon-sized "discharge cells" and the spontaneous discharge of a single cell is presumed to launch full breakdown of the composite. We obtain two empirical parameters, the mean and standard deviation of the spontaneous discharge field, by fitting breakdown data from two electrode geometries having roughly uniform fields but with greatly differing volumes of electrically stressed material. This model accounts for many aspects of our data, including the inherent statistical scatter and the dependence on the stressed volume, and it provides informative predictions with electrode geometries giving highly nonuniform fields. Issues related to computational spatial resolution and cutoff distance are also discussed.

  8. Dwarf Galaxies in Voids: Dark Matter Halos and Gas Cooling

    Directory of Open Access Journals (Sweden)

    Matthias Hoeft

    2010-01-01

    Full Text Available Galaxy surveys have shown that luminous galaxies are mainly distributed in large filaments and galaxy clusters. The remaining large volumes are virtually devoid of luminous galaxies. This is in concordance with the formation of the large-scale structure in the universe as derived from cosmological simulations. However, the numerical results indicate that cosmological voids are abundantly populated with dark matter haloes which may in principle host dwarf galaxies. Observational efforts have in contrast revealed that voids are apparently devoid of dwarf galaxies. We investigate the formation of dwarf galaxies in voids by hydrodynamical cosmological simulations. Due to the cosmic ultraviolet background radiation low-mass haloes show generally a reduced baryon fraction. We determine the characteristic mass below which dwarf galaxies are baryon deficient. We show that the circular velocity below which the accretion of baryons is suppressed is approximately 40 kms−1. The suppressed baryon accretion is caused by the photo-heating due to the UV background. We set up a spherical halo model and show that the effective equation of the state of the gas in the periphery of dwarf galaxies determines the characteristic mass. This implies that any process which heats the gas around dwarf galaxies increases the characteristic mass and thus reduces the number of observable dwarf galaxies.

  9. Evaluation of Voids on Shrink PVC Film by Varying Gravure Process Variables

    Directory of Open Access Journals (Sweden)

    Akshay Vijay Joshi

    2013-01-01

    Full Text Available Gravure is one of the widely used processes for printing on shrink films, the reason being its consistency for longer runs. However, printing these shrink films comes with new challenges. The presence of gels, black specks and other contaminations in these films do not allow the surrounding area to print resulting in print void. The occurrence of this defect in a considerable amount or size on the area of interest leads to the rejection of printed stock that involves wastage of inks, solvents and time. The research involves the investigation of the effect of gravure process variables on minimization of print voids in Shrink PVC film. The gravure process variables viz. viscosity, pressure, speed and hardness were identified for laser engraved cylinder. It was found that Hardness had a significant impact on minimizing the voids while Viscosity-Hardness interaction was important. The results showed reduction in void area with lower viscosity, higher pressure, lower speed and higher hardness.

  10. Mesenchymal Stromal Cell Therapy for Chronic Lung Allograft Dysfunction: Results of a First-in-Man Study.

    Science.gov (United States)

    Chambers, Daniel C; Enever, Debra; Lawrence, Sharon; Sturm, Marian J; Herrmann, Richard; Yerkovich, Stephanie; Musk, Michael; Hopkins, Peter M A

    2017-04-01

    Chronic lung transplant rejection (termed chronic lung allograft dysfunction [CLAD]) is the main impediment to long-term survival after lung transplantation. Bone marrow-derived mesenchymal stromal cells (MSCs) represent an attractive cell therapy in inflammatory diseases, including organ rejection, given their relative immune privilege and immunosuppressive and tolerogenic properties. Preclinical studies in models of obliterative bronchiolitis and human trials in graft versus host disease and renal transplantation suggest potential efficacy in CLAD. The purpose of this phase 1, single-arm study was to explore the feasibility and safety of intravenous delivery of allogeneic MSCs to patients with advanced CLAD. MSCs from unrelated donors were isolated from bone marrow, expanded and cryopreserved in a GMP-compliant facility. Patients had deteriorating CLAD and were bronchiolitis obliterans (BOS) grade ≥ 2 or grade 1 with risk factors for rapid progression. MSCs (2 x 10(6) cells per kilogram patient weight) were infused via a peripheral vein twice weekly for 2 weeks, with 52 weeks follow-up. Ten Patients (5 male, 8 bilateral, median [interquartile range] age 40 [30-59] years, 3 BOS2, 7 BOS3) participated. MSC treatment was well tolerated with all patients receiving the full dosing schedule without any procedure-related serious adverse events. The rate of decline in forced expiratory volume in one second slowed after the MSC infusions (120 ml/month preinfusion vs. 30 ml/month postinfusion, p = .08). Two patients died at 152 and 270 days post-MSC treatment, both from progressive CLAD. In conclusion, infusion of allogeneic bone marrow-derived MSCs is feasible and safe even in patients with advanced CLAD. Stem Cells Translational Medicine 2017;6:1152-1157.

  11. Long-Term Administration of Neuropeptide Y in the Subcutaneous Infusion Results in Cardiac Dysfunction and Hypertrophy in Rats.

    Science.gov (United States)

    Zhang, Rong; Niu, Huifang; Kang, Xiaohui; Ban, Tao; Hong, Hong; Ai, Jing

    2015-01-01

    The purpose of the present study was to clarify whether chronically elevated plasma neuropeptide Y (NPY) might affect heart function and cardiac remodeling in rats. Male Wistar rats were administered NPY (85 μg for 30 days) by mini-osmotic pump subcutaneously implanted between the scapulae. Associated indices for heart function, cardiac remodeling and hypertrophy were evaluated. Compared to the sham group, the baseline systolic blood pressure (SBP) in rats administered NPY was significantly increased; cardiac function was significantly decreased, as indicated by reduced ejection fraction (EF), left ventricular end-systolic pressure (LVESP), maximum change velocity of left ventricular pressure in the isovolumic contraction or relaxation period (± dp/dtmax) and increased left ventricular end-diastolic pressure (LVEDP); hematoxylin-eosin (H&E) staining detection displayed enlarged cell areas and a consistent increase in heart-to-body weight ratios (HW/BW) was observed; quantitative real time PCR (qRT-PCR) and Western blot analysis showed markedly increased expressions of β-myosin heavy chain (β-MHC), calcineurin (CaN) and phosphorylated p38 proteins, while no changes were found in the expressions of p38 total protein and the phosphorylations of JNK and ERK. This study reported for the first time that long-term elevated plasma concentration of NPY could induce cardiac dysfunction and cardiac hypertrophy and this phenomenon could, in part, be mediated by the Ca2+/CaM-dependent CaN pathway and p38 mitogen-activated protein kinase (MAPK) signal pathway in rats. © 2015 S. Karger AG, Basel.

  12. Failure by void coalescence in metallic materials containing primary and secondary voids subject to intense shearing

    DEFF Research Database (Denmark)

    Nielsen, Kim Lau; Tvergaard, Viggo

    2011-01-01

    , subject to shear dominated loading. To account for both length scales involved in this study, a continuum model that includes the softening effect of damage evolution in shear is used to represent the matrix material surrounding the primary voids. Here, a recently extended Gurson-type model is used, which......Failure under intense shearing at close to zero stress triaxiality is widely observed for ductile metallic materials, and is identified in experiments as smeared-out dimples on the fracture surface. Numerical cell-model studies of equal sized voids have revealed that the mechanism governing...... secondary damage that co-exists with or nucleation in the ligaments between larger voids that coalesce during intense shearing. A numerical cell-model study is carried out to gain a parametric understanding of the overall material response for different initial conditions of the two void populations...

  13. Partial discharge patterns related to surface deterioration in voids in epoxy

    OpenAIRE

    Holbøll, Joachim; Henriksen, Mogens

    1990-01-01

    Results are presented from an investigation of the relationship between changes in partial discharge patterns and the surface deterioration process taking place in small naturally formed spherical voids in epoxy plastic. The voids were exposed to a moderate electric stress above inception level, where partial discharges were present for more than 1500 h. Two types of electrical tree growth were found, the bush like tree and a single channel-like tree, which led to very different partial disch...

  14. Complications of untreated and ineffectively treated neurogenic bladder dysfunctions in children: our own practical classification.

    Science.gov (United States)

    Kroll, P; Zachwieja, J

    2016-04-01

    The neurogenic dysfunctions of the detrusor and the sphincter are caused by either a known congenital defect of the nervous system or by acquired damage to the nervous system. In patients with idiopathic bladder dysfunctions neurological examinations fail to reveal any pathology in the nervous system. The treatment strategy for the patient with detrusor-sphincter dysfunction should be based on a comprehensive functional and morphological evaluation. Clean Intermittent Catheterization is mandatory if voiding is ineffective. Reduced bladder capacity related to detrusor overactivity and decreased bladder walls compliance is successfully managed conservatively with oral anticholinergics. Conservative treatment prevents complications in the majority of patients. However, despite proper conservative treatment, some patients still develop complications. We propose our own practical classification of complications characteristic for the bladder and sphincter dysfunctions: 1. Urinary tract infections; 2. Urolithiasis; 3. Anatomic changes in the lower urinary tract; 4. Anatomic changes in the upper urinary tract; 5. Functional disturbances of kidneys parenchyma; 6. Urinary incontinence. Proposed practical classification of complications of bladder and sphincter dysfunctions is clear and simple. This classification can be used both in children with neurogenic and non-neurogenic dysfunctions. It is helpful in planning follow-up procedures and evaluation of treatment results.

  15. Probing cosmology and gravity with redshift-space distortions around voids

    CERN Document Server

    Hamaus, Nico; Lavaux, Guilhem; Wandelt, Benjamin D

    2015-01-01

    Cosmic voids in the large-scale structure of the Universe affect the peculiar motions of objects in their vicinity. Although these motions are difficult to observe directly, the clustering pattern of their surrounding tracers in redshift space is influenced in a unique way. This allows to investigate the interplay between densities and velocities around voids, which is solely dictated by the laws of gravity. With the help of N-body simulations and derived mock-galaxy catalogs we calculate the average density fluctuations inside and outside voids identified with a watershed algorithm in redshift space and compare the results with the expectation from general relativity and the LCDM model of cosmology. We find that simple linear-theory predictions work remarkably well in describing the dynamics of voids even on relatively small scales. Adopting a Bayesian inference framework, we determine the full posterior probability distribution of our model parameters and forecast the achievable accuracy on measurements of ...

  16. A Study of Fluctuations of Voids in Relativistic Ion-Ion Collisions

    CERN Document Server

    Ahmad, Shakeel; Khan, Shaista; Khatun, A; Irfan, M

    2015-01-01

    Event-by-event fluctuations (ebe) of hadronic patterns are investigated in terms of voids by analyzing the experimental data on 4.5, 14.5 and 60A GeV/c 16O-AgBr collisions. The findings are compared with the predictions of a multi-phase transport AMPT model. Dependence of voids on phase space bin width is examined in terms of two lowest moments of event-by-event fluctuations of voids, and Sq. The findings reveal that scaling exponent estimated from the observed power-law behavior of the voids may be used to characterize the various properties of hadronic phase transition. The results also rule out occurrence of 2nd order quark-hadron phase transition at the projectile energies considered.

  17. A proposed measurement method for void fraction in lubricant oil based on the image processing technique.

    Science.gov (United States)

    Wang, Jianwen; An, Qi

    2008-02-01

    A new method for measuring void fraction in lubricating oils is presented based on the image processing technique. The problem here differs from the bubbles detection problem in two-phase fluids in that our interest lies in the gross amount of gas voids in oils. Our method is based on an observation that gas voids in oils change the color of the mixed gas-oil material. Therefore, a measurement technique was established based on the change in color. In particular, the relationship between the change in color and amount of voids was established experimentally. The experiment and testing were performed on a particular setup which consists of a pipe, oil, and air. The test result has shown that this method is effective. The method is the simplest and most accurate one among the existing methods.

  18. Approximate yield criteria for anisotropic metals with prolate or oblate voids

    Science.gov (United States)

    Monchiet, Vincent; Gruescu, Cosmin; Charkaluk, Eric; Kondo, Djimedo

    2006-07-01

    Following the study of Gologanu et al. (1997) which has extended the well-known approach of Gurson (1975), we propose approximate yield criteria for anisotropic plastic voided metals containing non spherical cavities. The plastic anisotropy of the matrix is described by means of Hill's quadratic criterion. The procedure to establish the closed form expression of approximate macroscopic criteria, in which void shape and plastic anisotropic effects are included, is detailed. The new criteria allow us to recover existing results in the cases of spherical and cylindrical voids in an Hill type plastic matrix. Moreover, they agree with previous criteria for non spherical voids in an isotropic plastic matrix. Finally, for validation purposes, we provide, in the general case of non spherical cavities in the anisotropic matrix, a comparison with the numerical exact two field criteria. To cite this article: V. Monchiet et al., C. R. Mecanique 334 (2006).

  19. Three-Dimensional Computed Tomography as a Method for Finding Die Attach Voids in Diodes

    Science.gov (United States)

    Brahm, E. N.; Rolin, T. D.

    2010-01-01

    NASA analyzes electrical, electronic, and electromechanical (EEE) parts used in space vehicles to understand failure modes of these components. The diode is an EEE part critical to NASA missions that can fail due to excessive voiding in the die attach. Metallography, one established method for studying the die attach, is a time-intensive, destructive, and equivocal process whereby mechanical grinding of the diodes is performed to reveal voiding in the die attach. Problems such as die attach pull-out tend to complicate results and can lead to erroneous conclusions. The objective of this study is to determine if three-dimensional computed tomography (3DCT), a nondestructive technique, is a viable alternative to metallography for detecting die attach voiding. The die attach voiding in two- dimensional planes created from 3DCT scans was compared to several physical cross sections of the same diode to determine if the 3DCT scan accurately recreates die attach volumetric variability

  20. Conclusive evidence of abrupt coagulation inside the void during cyclic nanoparticle formation in reactive plasma

    Science.gov (United States)

    van de Wetering, F. M. J. H.; Nijdam, S.; Beckers, J.

    2016-07-01

    In this letter, we present scanning electron microscopy (SEM) results that confirm in a direct way our earlier explanation of an abrupt coagulation event as the cause for the void hiccup. In a recent paper, we reported on the fast and interrupted expansion of voids in a reactive dusty argon-acetylene plasma. The voids appeared one after the other, each showing a peculiar, though reproducible, behavior of successive periods of fast expansion, abrupt contraction, and continued expansion. The abrupt contraction was termed "hiccup" and was related to collective coagulation of a new generation of nanoparticles growing in the void using relatively indirect methods: electron density measurements and optical emission spectroscopy. In this letter, we present conclusive evidence using SEM of particles collected at different moments in time spanning several growth cycles, which enables us to follow the nanoparticle formation process in great detail.

  1. Ultrasonic Techniques for Air Void Size Distribution and Property Evaluation in Both Early-Age and Hardened Concrete Samples

    Directory of Open Access Journals (Sweden)

    Shuaicheng Guo

    2017-03-01

    Full Text Available Entrained air voids can improve the freeze-thaw durability of concrete, and also affect its mechanical and transport properties. Therefore, it is important to measure the air void structure and understand its influence on concrete performance for quality control. This paper aims to measure air void structure evolution at both early-age and hardened stages with the ultrasonic technique, and evaluates its influence on concrete properties. Three samples with different air entrainment agent content were specially prepared. The air void structure was determined with optimized inverse analysis by achieving the minimum error between experimental and theoretical attenuation. The early-age sample measurement showed that the air void content with the whole size range slightly decreases with curing time. The air void size distribution of hardened samples (at Day 28 was compared with American Society for Testing and Materials (ASTM C457 test results. The air void size distribution with different amount of air entrainment agent was also favorably compared. In addition, the transport property, compressive strength, and dynamic modulus of concrete samples were also evaluated. The concrete transport decreased with the curing age, which is in accordance with the air void shrinkage. The correlation between the early-age strength development and hardened dynamic modulus with the ultrasonic parameters was also evaluated. The existence of clustered air voids in the Interfacial Transition Zone (ITZ area was found to cause severe compressive strength loss. The results indicated that this developed ultrasonic technique has potential in air void size distribution measurement, and demonstrated the influence of air void structure evolution on concrete properties during both early-age and hardened stages.

  2. Structural analyses of a rigid pavement overlaying a sub-surface void

    Science.gov (United States)

    Adam, Fatih Alperen

    Pavement failures are very hazardous for public safety and serviceability. These failures in pavements are mainly caused by subsurface voids, cracks, and undulation at the slab-base interface. On the other hand, current structural analysis procedures for rigid pavement assume that the slab-base interface is perfectly planar and no imperfections exist in the sub-surface soil. This assumption would be violated if severe erosion were to occur due to inadequate drainage, thermal movements, and/or mechanical loading. Until now, the effect of erosion was only considered in the faulting performance model, but not with regards to transverse cracking at the mid-slab edge. In this research, the bottom up fatigue cracking potential, caused by the combined effects of wheel loading and a localized imperfection in the form of a void below the mid-slab edge, is studied. A robust stress and surface deflection analysis was also conducted to evaluate the influence of a sub-surface void on layer moduli back-calculation. Rehabilitative measures were considered, which included a study on overlay and fill remediation. A series regression of equations was proposed that provides a relationship between void size, layer moduli stiffness, and the overlay thickness required to reduce the stress to its original pre-void level. The effect of the void on 3D pavement crack propagation was also studied under a single axle load. The amplifications to the stress intensity was shown to be high but could be mitigated substantially if stiff material is used to fill the void and impede crack growth. The pavement system was modeled using the commercial finite element modeling program Abaqus RTM. More than 10,000 runs were executed to do the following analysis: stress analysis of subsurface voids, E-moduli back-calculation of base layer, pavement damage calculations of Beaumont, TX, overlay thickness estimations, and mode I crack analysis. The results indicate that the stress and stress intensity are, on

  3. POLAR DISK GALAXY FOUND IN WALL BETWEEN VOIDS

    NARCIS (Netherlands)

    Stanonik, K.; Platen, E.; Aragon-Calvo, M. A.; van Gorkom, J. H.; van de Weygaert, R.; van der Hulst, J. M.; Peebles, P. J. E.

    2009-01-01

    We have found an isolated polar disk galaxy in what appears to be a cosmological wall situated between two voids. This void galaxy is unique as its polar disk was discovered serendipitously in an Hi survey of SDSS void galaxies, with no optical counterpart to the Hi polar disk. Yet the Hi mass in th

  4. Void Coalescence Processes Quantified Through Atomistic and Multiscale Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Rudd, R E; Seppala, E T; Dupuy, L M; Belak, J

    2007-01-12

    Simulation of ductile fracture at the atomic scale reveals many aspects of the fracture process including specific mechanisms associated with void nucleation and growth as a precursor to fracture and the plastic deformation of the material surrounding the voids and cracks. Recently we have studied void coalescence in ductile metals using large-scale atomistic and continuum simulations. Here we review that work and present some related investigations. The atomistic simulations involve three-dimensional strain-controlled multi-million atom molecular dynamics simulations of copper. The correlated growth of two voids during the coalescence process leading to fracture is investigated, both in terms of its onset and the ensuing dynamical interactions. Void interactions are quantified through the rate of reduction of the distance between the voids, through the correlated directional growth of the voids, and through correlated shape evolution of the voids. The critical inter-void ligament distance marking the onset of coalescence is shown to be approximately one void radius based on the quantification measurements used, independent of the initial separation distance between the voids and the strain-rate of the expansion of the system. No pronounced shear flow is found in the coalescence process. We also discuss a technique for optimizing the calculation of fine-scale information on the fly for use in a coarse-scale simulation, and discuss the specific case of a fine-scale model that calculates void growth explicitly feeding into a coarse-scale mechanics model to study damage localization.

  5. POLAR DISK GALAXY FOUND IN WALL BETWEEN VOIDS

    NARCIS (Netherlands)

    Stanonik, K.; Platen, E.; Aragon-Calvo, M. A.; van Gorkom, J. H.; van de Weygaert, R.; van der Hulst, J. M.; Peebles, P. J. E.

    2009-01-01

    We have found an isolated polar disk galaxy in what appears to be a cosmological wall situated between two voids. This void galaxy is unique as its polar disk was discovered serendipitously in an Hi survey of SDSS void galaxies, with no optical counterpart to the Hi polar disk. Yet the Hi mass in th

  6. Dilational Response of Voided Polycrystals

    Science.gov (United States)

    Savage, Daniel J.; Cazacu, Oana; Knezevic, Marko

    2017-02-01

    Finite-element (FE) cell model computations have been used to gain insights into the ductile response of porous polycrystals. Generally, the behavior of the matrix is described by a J 2-plasticity model. In this article, we present a new computational approach to FE cell models for porous polycrystals deforming by slip based on crystal plasticity. The cell provides the homogenized dilational response, where the constitutive response of every integration point is based on a single-crystal visco-plasticity law. The calculations are performed for a body-centered cubic polycrystal with random texture. Axisymmetric tensile and compressive loadings are imposed corresponding to the fixed values of the stress triaxiality and to two possible values of the Lode parameter. The resulting numerical yield points are compared with those obtained using a J 2-FE cell and an analytical model. The predictions confirm the combined effects of the mean stress and third-invariant on yielding recently revealed by the analytical model.

  7. "Dark energy" in the Local Void

    CERN Document Server

    Villata, M

    2012-01-01

    The unexpected discovery of the accelerated cosmic expansion in 1998 has filled the Universe with the embarrassing presence of an unidentified "dark energy", or cosmological constant, devoid of any physical meaning. While this standard cosmology seems to work well at the global level, improved knowledge of the kinematics and other properties of our extragalactic neighborhood indicates the need for a better theory. We investigate whether the recently suggested repulsive-gravity scenario can account for some of the features that are unexplained by the standard model. Through simple dynamical considerations, we find that the Local Void could host an amount of antimatter ($\\sim5\\times10^{15}\\,M_\\odot$) roughly equivalent to the mass of a typical supercluster, thus restoring the matter-antimatter symmetry. The antigravity field produced by this "dark repulsor" can explain the anomalous motion of the Local Sheet away from the Local Void, as well as several other properties of nearby galaxies that seem to require vo...

  8. Molecular Gas and Star Formation in Voids

    CERN Document Server

    Das, M; Iono, D; Honey, M; Ramya, S

    2014-01-01

    We present the detection of molecular gas using CO(1-0) line emission and follow up Halpha imaging observations of galaxies located in nearby voids. The CO(1-0) observations were done using the 45m telescope of the Nobeyama Radio Observatory (NRO) and the optical observations were done using the Himalayan Chandra Telescope (HCT). Although void galaxies lie in the most under dense parts of our universe, a significant fraction of them are gas rich, spiral galaxies that show signatures of ongoing star formation. Not much is known about their cold gas content or star formation properties. In this study we searched for molecular gas in five void galaxies using the NRO. The galaxies were selected based on their relatively higher IRAS fluxes or Halpha line luminosities. CO(1--0) emission was detected in four galaxies and the derived molecular gas masses lie between (1 - 8)E+9 Msun. The H$\\alpha$ imaging observations of three galaxies detected in CO emission indicates ongoing star formation and the derived star forma...

  9. Decomposition Analysis of Void Reactivity Coefficient for Innovative and Modified BWR Assemblies

    Directory of Open Access Journals (Sweden)

    Andrius Slavickas

    2014-01-01

    Full Text Available The decomposition analysis of void reactivity coefficient for innovative BWR assemblies is presented in this paper. The innovative assemblies were loaded with high enrichment UO2 and MOX fuels. Additionally the impact of the moderation enhancement on the void reactivity coefficient through a full fuel burnup discharge interval was investigated for the innovative assembly with MOX fuel. For the numerical analysis the TRITON functional module of SCALE code with ENDF/B-VI cross section library was applied. The obtained results indicate the influence of the most important isotopes to the void reactivity behaviour over a fuel burnup interval of 70 GWd/t for both UO2 and MOX fuels. From the neutronic safety concern positive void reactivity coefficient values are observed for MOX fuel at the beginning of the fuel irradiation cycle. For extra-moderated assembly designs, implementing 8 and 12 water holes, the neutron spectrum softening is achieved and consequently the lower void reactivity values. Variations in void reactivity coefficient values are explained by fulfilled decomposition analysis based on neutrons absorption reactions for separate isotopes.

  10. Void shape control in GaN re-grown on hexagonally patterned mask-less GaN

    Science.gov (United States)

    Ali, M.; Romanov, A. E.; Suihkonen, S.; Svensk, O.; Törmä, P. T.; Sopanen, M.; Lipsanen, H.; Odnoblyudov, M. A.; Bougrov, V. E.

    2011-01-01

    We present the results of GaN re-growth on hexagonally patterned GaN templates. Sapphire was used as the original substrate and the samples were grown by metalorganic vapor phase epitaxy (MOVPE). The re-growth on the patterned templates results in the formation of voids at the GaN/sapphire interface. Our extensive scanning electron microscopy (SEM)-based experimental investigations show that the void shape can be controlled from nearly vertical to fully inclined configurations. It was found that the initial hexagon hole diameter plays a key role in determining the final profile of the void sidewalls. X-ray diffraction analysis of the GaN layers indicates that the layers with inclined sidewall voids have an improved crystalline quality. Knowledge of the void configurations in the GaN layers and a possibility to control their shape can help in enhancing light extraction from the light emitting structures.

  11. Nonlocal plasticity effects on interaction of different size voids

    DEFF Research Database (Denmark)

    Tvergaard, Viggo; Niordson, Christian Frithiof

    2004-01-01

    A nonlocal elastic-plastic material model is used to show that the rate of void growth is significantly reduced when the voids are small enough to be comparable with a characteristic material length. For a very small void in the material between much larger voids the competition between...... an increased growth rate due to the stress concentrations around the larger voids and a reduced growth rate due to the nonlocal effects is studied. The analyses are based on an axisymmetric unit cell model with special boundary conditions, which allow for a relatively simple investigation of a full three...

  12. The Void Galaxy Survey: Photometry, structure and identity of void galaxies

    CERN Document Server

    Beygu, B; van der Hulst, J M; Jarrett, T H; Kreckel, K; van de Weygaert, R; van Gorkom, J H; Aragon-Calvo, M A

    2016-01-01

    We analyze photometry from deep B-band images of 59 void galaxies in the Void Galaxy Survey (VGS), together with their near-infrared 3.6$\\mu$m and 4.5$\\mu$m Spitzer photometry. The VGS galaxies constitute a sample of void galaxies that were selected by a geometric-topological procedure from the SDSS DR7 data release, and which populate the deep interior of voids. Our void galaxies span a range of absolute B-magnitude from $\\rm{M_B=-15.5}$ to $\\rm{M_B=-20}$, while at the 3.6$\\mu$m band their magnitudes range from $\\rm{M_{3.6}=-18}$ to $\\rm{M_{3.6}=-24}$. Their B-[3.6] colour and structural parameters indicate these are star forming galaxies. A good reflection of the old stellar population, the near-infrared band photometry also provide a robust estimate of the stellar mass, which for the VGS galaxies we confirm to be smaller than $3 \\times 10^{10}$ M$_\\odot$. In terms of the structural parameters and morphology, our findings align with other studies in that our VGS galaxy sample consists mostly of small late-t...

  13. Percutaneous coronary intervention for acute myocardial infarction in elderly patients with renal dysfunction: results from the Korea Acute Myocardial Infarction Registry.

    Science.gov (United States)

    Lim, Sang Yup; Bae, Eun Hui; Choi, Joon Seok; Kim, Chang Seong; Ma, Seong Kwon; Ahn, Youngkeun; Jeong, Myung Ho; Kim, Weon; Woo, Jong Shin; Kim, Young Jo; Cho, Myeong Chan; Kim, Chong Jin; Kim, Soo Wan

    2013-07-01

    This study aimed to evaluate the effects of percutaneous coronary intervention (PCI) on short- and long-term major adverse cardiac events (MACE) in elderly (>75 yr old) acute myocardial infarction (AMI) patients with renal dysfunction. As part of Korea AMI Registry (KAMIR), elderly patients with AMI and renal dysfunction (GFRrenal dysfunction, PCI therapy yields favorable in-hospital and short-term and long-term MACE-free survival.

  14. Void Coalescence Processes Quantified through Atomistic and Multiscale Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Rudd, R E; Seppala, E T; Dupuy, L M; Belak, J

    2005-12-31

    Simulation of ductile fracture at the atomic scale reveals many aspects of the fracture process including specific mechanisms associated with void nucleation and growth as a precursor to fracture and the plastic deformation of the material surrounding the voids and cracks. Recently we have studied void coalescence in ductile metals using large-scale atomistic and continuum simulations. Here we review that work and present some related investigations. The atomistic simulations involve three-dimensional strain-controlled multi-million atom molecular dynamics simulations of copper. The correlated growth of two voids during the coalescence process leading to fracture is investigated, both in terms of its onset and the ensuing dynamical interactions. Void interactions are quantified through the rate of reduction of the distance between the voids, through the correlated directional growth of the voids, and through correlated shape evolution of the voids. The critical inter-void ligament distance marking the onset of coalescence is shown to be approximately one void radius based on the quantification measurements used, independent of the initial separation distance between the voids and the strain-rate of the expansion of the system. No pronounced shear flow is found in the coalescence process.

  15. A Cosmic Void Catalog of SDSS DR12 BOSS Galaxies

    Science.gov (United States)

    Mao, Qingqing; Berlind, Andreas A.; Scherrer, Robert J.; Neyrinck, Mark C.; Scoccimarro, Román; Tinker, Jeremy L.; McBride, Cameron K.; Schneider, Donald P.; Pan, Kaike; Bizyaev, Dmitry; Malanushenko, Elena; Malanushenko, Viktor

    2017-02-01

    We present a cosmic void catalog using the large-scale structure galaxy catalog from the Baryon Oscillation Spectroscopic Survey (BOSS). This galaxy catalog is part of the Sloan Digital Sky Survey (SDSS) Data Release 12 and is the final catalog of SDSS-III. We take into account the survey boundaries, masks, and angular and radial selection functions, and apply the ZOBOV void finding algorithm to the Galaxy catalog. We identify a total of 10,643 voids. After making quality cuts to ensure that the voids represent real underdense regions, we obtain 1,228 voids with effective radii spanning the range 20–100 {h}-1 {Mpc} and with central densities that are, on average, 30% of the mean sample density. We release versions of the catalogs both with and without quality cuts. We discuss the basic statistics of voids, such as their size and redshift distributions, and measure the radial density profile of the voids via a stacking technique. In addition, we construct mock void catalogs from 1000 mock galaxy catalogs, and find that the properties of BOSS voids are in good agreement with those in the mock catalogs. We compare the stellar mass distribution of galaxies living inside and outside of the voids, and find no large difference. These BOSS and mock void catalogs are useful for a number of cosmological and galaxy environment studies.

  16. Clinical Characteristics and Urodynamic Analysis of Urinary Dysfunction in Multiple Sclerosis

    Institute of Scientific and Technical Information of China (English)

    Tao Wang; Wei Huang; Yong Zhang

    2016-01-01

    Background:Both lower urinary tract dysfunction and urinary symptoms are prevalent in patients with multiple sclerosis (MS).Although the significance of identifying and treating urinary symptoms in MS is currently well-known,there is no information about the real prevalence and therapeutic effect of urinary symptoms in patients with MS.The purpose of this study was to analyze the major symptoms and urodynamic abnormalities,and observe the therapeutic effect in different MS characteristics.Methods:We enrolled 126 patients with urological dysfunction who were recruited between July 2008 and January 2015 in Beijing Tian Tan Hospital,Capital Medical University and conducted overactive bladder system score (OABSS),urodynamic investigation,and expanded disability status scale (EDSS).Changes of urinary symptoms and urodynamic parameters were investigated.Results:Urgency was the predominant urinary symptom,and detrusor overactivity was the major bladder dysfunction.There was a positive correlation between EDSS and OABSS.Clinically isolated syndrome (CIS) had lowest EDSS and OABSS.CIS exhibited significant improvements in OABSS,maximum urinary flow rate (Qmax),and bladder volume at the first desire to voiding and maximum bladder volume after the treatment (P < 0.05).Relapsing-remitting MS showed significant improvements in the OABSS,Qmax,and bladder volume at the first desire to voiding,maximum bladder volume and bladder compliance after the treatment (P < 0.05).Progressive MS exhibited significant increase in the bladder volume at the first desire to voiding,the detrusor pressure at maximum flow rate (PdetQmax),and bladder compliance after the treatment (P < 0.05).Conclusions:Urodynamic parameters examined are important in providing an accurate diagnosis,guiding management decisions of MS.Early and effective treatment may improve the bladder function and the quality of life at the early stages of MS.

  17. Experimental data suggesting that inflammation mediated rat liver mitochondrial dysfunction results from secondary hypoxia rather than from direct effects of inflammatory mediators

    Directory of Open Access Journals (Sweden)

    Adelheid eWeidinger

    2013-06-01

    Full Text Available Systemic inflammatory response (SIR comprises direct effects of inflammatory mediators (IM and indirect effects, such as secondary circulatory failure which results in tissue hypoxia (HOX. These two key components, SIR and HOX, cause multiple organ failure (MOF. Since HOX and IM occur and interact simultaneously in vivo, it is difficult to clarify their individual pathological impact. To eliminate this interaction, precision cut liver slices (PCLS were used in this study aiming to dissect the effects of HOX and IM on mitochondrial function, integrity of cellular membrane and the expression of genes associated with inflammation. HOX was induced by incubating PCLS or rat liver mitochondria at pO2<1% followed by reoxygenation (HOX/ROX model. Inflammatory injury was stimulated by incubating PCLS with IM (IM model. We found upregulation of inducible nitric oxide synthase (iNOS expression only in the IM model, while heme oxygenase 1 (HO-1 expression was upregulated only in the HOX/ROX model. Elevated expression of interleukin 6 (IL-6 was found in both models reflecting converging pathways regulating the expression of this gene. Both models caused damage to hepatocytes resulting in the release of alanine aminotransferase (ALT. The leakage of aspartate aminotransferase (AST was observed only during the hypoxic phase in the HOX/ROX model. The reoxygenation phase of HOX, but not IM, drastically impaired mitochondrial electron supply via complex I and II. Additional experiments performed with isolated mitochondria showed that free iron, released during HOX, is likely a key prerequisite of mitochondrial dysfunction induced during the reoxygenation phase. Our data suggests that mitochondrial dysfunction, previously observed in in vivo SIR-models is the result of secondary circulatory failure inducing HOX rather than the result of a direct interaction of IM with liver cells.

  18. Design of capacitance sensor system for void fraction measurement

    Institute of Scientific and Technical Information of China (English)

    LIU Yi-ping; NIU Gang; WANG Jing

    2005-01-01

    Simulation and optimization were applied to a capacitive sensor system based on electrical tomography technology.Sensors, consisting of Morgantown Energy Technology Center (METC) axial synchro driving guard electrodes and two sets of detecting electrodes, make it possible to obtain simultaneously two groups of signals of the void fraction in oil-gas two-phase flow.The computational and experimental results showed that available sensors, charactered by high resolution and fast real-time response can be used for real-time liquid-gas two-phase flow pattern determination.

  19. Dependence on supernovae light-curve processing in void models

    Energy Technology Data Exchange (ETDEWEB)

    Bengochea, Gabriel R., E-mail: gabriel@iafe.uba.ar [Instituto de Astronomía y Física del Espacio (IAFE), UBA-CONICET, CC 67, Suc. 28, 1428 Buenos Aires (Argentina); De Rossi, Maria E., E-mail: derossi@iafe.uba.ar [Instituto de Astronomía y Física del Espacio (IAFE), UBA-CONICET, CC 67, Suc. 28, 1428 Buenos Aires (Argentina); Departamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (Argentina)

    2014-06-02

    In this work, we show that when supernova Ia (SN Ia) data sets are used to put constraints on the free parameters of inhomogeneous models, certain extra information regarding the light-curve fitter used in the supernovae Ia luminosity fluxes processing should be taken into account. We found that the size of the void as well as other parameters of these models might be suffering extra degenerations or additional systematic errors due to the fitter. A recent proposal to relieve the tension between the results from Planck satellite and SNe Ia is re-analyzed in the framework of these subjects.

  20. Molecular fingerprint of high fat diet induced urinary bladder metabolic dysfunction in a rat model.

    Directory of Open Access Journals (Sweden)

    Andreas Oberbach

    Full Text Available AIMS/HYPOTHESIS: Diabetic voiding dysfunction has been reported in epidemiological dimension of individuals with diabetes mellitus. Animal models might provide new insights into the molecular mechanisms of this dysfunction to facilitate early diagnosis and to identify new drug targets for therapeutic interventions. METHODS: Thirty male Sprague-Dawley rats received either chow or high-fat diet for eleven weeks. Proteomic alterations were comparatively monitored in both groups to discover a molecular fingerprinting of the urinary bladder remodelling/dysfunction. Results were validated by ELISA, Western blotting and immunohistology. RESULTS: In the proteome analysis 383 proteins were identified and canonical pathway analysis revealed a significant up-regulation of acute phase reaction, hypoxia, glycolysis, β-oxidation, and proteins related to mitochondrial dysfunction in high-fat diet rats. In contrast, calcium signalling, cytoskeletal proteins, calpain, 14-3-3η and eNOS signalling were down-regulated in this group. Interestingly, we found increased ubiquitin proteasome activity in the high-fat diet group that might explain the significant down-regulation of eNOS, 14-3-3η and calpain. CONCLUSIONS/INTERPRETATION: Thus, high-fat diet is sufficient to induce significant remodelling of the urinary bladder and alterations of the molecular fingerprint. Our findings give new insights into obesity related bladder dysfunction and identified proteins that may indicate novel pathophysiological mechanisms and therefore constitute new drug targets.

  1. The void galaxy survey: photometry, structure and identity of void galaxies

    Science.gov (United States)

    Beygu, B.; Peletier, R. F.; van der Hulst, J. M.; Jarrett, T. H.; Kreckel, K.; van de Weygaert, R.; van Gorkom, J. H.; Aragon-Calvo, M. A.

    2017-01-01

    We analyse photometry from deep B-band images of 59 void galaxies in the Void Galaxy Survey (VGS), together with their near-infrared 3.6 μm and 4.5 μm Spitzer photometry. The VGS galaxies constitute a sample of void galaxies that were selected by a geometric-topological procedure from the Sloan Digital Sky Survey Data Release 7 data release, and which populate the deep interior of voids. Our void galaxies span a range of absolute B-magnitude from MB = -15.5 to -20, while at the 3.6 μm band their magnitudes range from M3.6 = -18 to -24. Their B-[3.6] colour and structural parameters indicate these are star-forming galaxies. A good reflection of the old stellar population, the near-infrared band photometry also provide a robust estimate of the stellar mass, which for the VGS galaxies we confirm to be smaller than 3 × 1010 M⊙. In terms of the structural parameters and morphology, our findings align with other studies in that our VGS galaxy sample consists mostly of small late-type galaxies. Most of them are similar to Sd-Sm galaxies, although a few are irregularly shaped galaxies. The sample even includes two early-type galaxies, one of which is an AGN. Their Sérsic indices are nearly all smaller than n = 2 in both bands and they also have small half-light radii. In all, we conclude that the principal impact of the void environment on the galaxies populating them mostly concerns their low stellar mass and small size.

  2. Collapse of elongated voids in porous energetic materials: Effects of void orientation and aspect ratio on initiation

    Science.gov (United States)

    Rai, Nirmal Kumar; Schmidt, Martin J.; Udaykumar, H. S.

    2017-04-01

    The sensitivity of porous energetic materials depends on mesostructural heterogeneities such as voids, defects, cracks, and grain boundaries. The mesostructure of pressed explosives contains voids of arbitrary shapes including elongated voids of various orientations and aspect ratios. Mesoscale simulations to date have analyzed the effect of void morphology on the sensitivity of energetic materials for idealized shapes such as cylindrical, conical, and elliptical. This work analyzes the sensitivity behavior of elongated voids in an HMX matrix subject to shock loading. Simulations show that sensitivity of elongated voids depends strongly on orientation as well as aspect ratio. Ranges of orientations and aspects ratios are identified that enhance or inhibit initiation. Insights obtained from single elongated void analyses are used to identify sensitive locations in an imaged mesostructure of a pressed explosive sample.

  3. Systemic platelet dysfunction is the result of local dysregulated coagulation and platelet activation in the brain in a rat model of isolated traumatic brain injury.

    Science.gov (United States)

    Ploplis, Victoria A; Donahue, Deborah L; Sandoval-Cooper, Mayra J; MorenoCaffaro, Maria; Sheets, Patrick; Thomas, Scott G; Walsh, Mark; Castellino, Francis J

    2014-10-01

    Coagulopathy after severe traumatic brain injury (TBI) has been extensively reported. Clinical studies have identified a strong relationship between diminished platelet-rich thrombus formation, responsiveness to adenosine diphosphate agonism, and severity of TBI. The mechanisms that lead to platelet dysfunction in the acute response to TBI are poorly understood. The development of a rodent model of TBI that mimics the coagulopathy observed clinically has recently been reported. Using immunohistochemical techniques and thromboelastography platelet mapping, the current study demonstrated that the expression of coagulation (tissue factor and fibrin) and platelet activation (P-selectin) markers in the injured brain paralleled the alteration in systemic platelet responsiveness to the agonists, adenosine diphosphate and arachodonic acid. Results of this study demonstrate that local procoagulant changes in the injured brain have profound effects on systemic platelet function.

  4. Plasticity size effects in voided crystals

    DEFF Research Database (Denmark)

    Hussein, M. I.; Borg, Ulrik; Niordson, Christian Frithiof

    singularities in an elastic material. The lattice resistance to dislocation motion, dislocation nucleation, dislocation interaction with obstacles and annihilation are incorporated through a set of constitutive rules. Over the range of length scales investigated, both the discrete dislocation and strain...... predictions of the two formulations for all crystal types and void volume fractions considered when the material length scale in the non-local plasticity model chosen to be $0.325\\mu m$ (around ten times the slip plane spacing in the discrete dislocation models)....

  5. Plasticity size effects in voided crystals

    DEFF Research Database (Denmark)

    Hussein, M.I.; Borg, Ulrik; Niordson, Christian Frithiof

    2008-01-01

    as line singularities in an elastic material. The lattice resistance to dislocation motion, dislocation nucleation, dislocation interaction with obstacles and annihilation are incorporated through a set of constitutive rules. Over the range of length scales investigated, both the discrete dislocation...... between predictions of the two formulations for all crystal types and void volume fractions considered when the material length scale in the non-local plasticity model is chosen to be 0.325 mu m (about 10 times the slip plane spacing in the discrete dislocation models)....

  6. Erectile dysfunction.

    Science.gov (United States)

    Wylie, Kevan

    2008-01-01

    Erectile dysfunction is a common problem affecting sexual function in men. Approximately one in 10 men over the age of 40 is affected by this condition and the incidence is age related. Erectile dysfunction is a sentinel marker for several reversible conditions including peripheral and coronary vascular disease, hypertension and diabetes mellitus. Endothelial dysfunction is a common factor between the disease states. Concurrent conditions such as depression, late-onset hypogonadism, Peyronie's disease and lower urinary tract symptoms may significantly worsen erectile function, other sexual and relationship issues and penis dysmorphophobia. A focused physical examination and baseline laboratory investigations are mandatory. Management consists of initiating modifiable lifestyle changes, psychological and psychosexual/couples interventions and pharmacological and other interventions. In combination and with treatment of concurrent comorbid states, these interventions will often bring about successful resolution of symptoms and avoid the need for surgical interventions.

  7. Voids in Ly{\\alpha} Forest Tomographic Maps

    CERN Document Server

    Stark, Casey W; White, Martin; Lee, Khee-Gan

    2015-01-01

    We present a new method of finding cosmic voids using tomographic maps of Ly{\\alpha} forest flux. We identify cosmological voids with radii of 2 - 12 $h^{-1}$Mpc in a large N-body simulation at $z = 2.5$, and characterize the signal of the high-redshift voids in density and Ly{\\alpha} forest flux. The void properties are similar to what has been found at lower redshifts, but they are smaller and have steeper radial density profiles. Similarly to what has been found for low-redshift voids, the radial velocity profiles have little scatter and agree very well with the linear theory prediction. We run the same void finder on an ideal Ly{\\alpha} flux field and tomographic reconstructions at various spatial samplings. We compare the tomographic map void catalogs to the density void catalog and find good agreement even with modest-sized voids ($r > 6 \\, h^{-1}$Mpc). Using our simple void-finding method, the configuration of the ongoing CLAMATO survey covering 1 deg$^2$ would provide a sample of about 100 high-redshi...

  8. The sparkling Universe: the coherent motions of cosmic voids

    CERN Document Server

    Lambas, Diego G; Ceccarelli, Laura; Ruiz, Andrés N; Paz, Dante J; Maldonado, Victoria E; Luparello, Heliana E

    2015-01-01

    We compute the bulk motions of cosmic voids, using a $\\Lambda$CDM numerical simulation considering the mean velocities of the dark matter inside the void itself and that of the haloes in the surrounding shell. We find coincident values of these two measures in the range $\\sim$ 300-400 km/s, not far from the expected mean peculiar velocities of groups and galaxy clusters. When analysing the distribution of the pairwise relative velocities of voids, we find a remarkable bimodal behaviour consistent with an excess of both systematically approaching and receding voids. We determine that the origin of this bimodality resides in the void large scale environment, since once voids are classified into void-in-void (R-type) or void-in-cloud (S-type), R-types are found mutually receding away, while S-types approach each other. The magnitude of these systematic relative velocities account for more than 100 km/s, reaching large coherence lengths of up to 200 h$^{-1}$ Mpc . We have used samples of voids from the Sloan Digi...

  9. Effects of Voids on Concrete Tensile Fracturing: A Mesoscale Study

    Directory of Open Access Journals (Sweden)

    Lei Xu

    2017-01-01

    Full Text Available A two-dimensional mesoscale modeling framework, which considers concrete as a four-phase material including voids, is developed for studying the effects of voids on concrete tensile fracturing under the plane stress condition. Aggregate is assumed to behave elastically, while a continuum damaged plasticity model is employed to describe the mechanical behaviors of mortar and ITZ. The effects of voids on the fracture mechanism of concrete under uniaxial tension are first detailed, followed by an extensive investigation of the effects of void volume fraction on concrete tensile fracturing. It is found that both the prepeak and postpeak mesoscale cracking in concrete are highly affected by voids, and there is not a straightforward relation between void volume fraction and the postpeak behavior due to the randomness of void distribution. The fracture pattern of concrete specimen with voids is controlled by both the aggregate arrangement and the distribution of voids, and two types of failure modes are identified for concrete specimens under uniaxial tension. It is suggested that voids should be explicitly modeled for the accurate fracturing simulation of concrete on the mesoscale.

  10. Mutation of zebrafish dihydrolipoamide branched-chain transacylase E2 results in motor dysfunction and models maple syrup urine disease

    Directory of Open Access Journals (Sweden)

    Timo Friedrich

    2012-03-01

    Analysis of zebrafish mutants that demonstrate abnormal locomotive behavior can elucidate the molecular requirements for neural network function and provide new models of human disease. Here, we show that zebrafish quetschkommode (que mutant larvae exhibit a progressive locomotor defect that culminates in unusual nose-to-tail compressions and an inability to swim. Correspondingly, extracellular peripheral nerve recordings show that que mutants demonstrate abnormal locomotor output to the axial muscles used for swimming. Using positional cloning and candidate gene analysis, we reveal that a point mutation disrupts the gene encoding dihydrolipoamide branched-chain transacylase E2 (Dbt, a component of a mitochondrial enzyme complex, to generate the que phenotype. In humans, mutation of the DBT gene causes maple syrup urine disease (MSUD, a disorder of branched-chain amino acid metabolism that can result in mental retardation, severe dystonia, profound neurological damage and death. que mutants harbor abnormal amino acid levels, similar to MSUD patients and consistent with an error in branched-chain amino acid metabolism. que mutants also contain markedly reduced levels of the neurotransmitter glutamate within the brain and spinal cord, which probably contributes to their abnormal spinal cord locomotor output and aberrant motility behavior, a trait that probably represents severe dystonia in larval zebrafish. Taken together, these data illustrate how defects in branched-chain amino acid metabolism can disrupt nervous system development and/or function, and establish zebrafish que mutants as a model to better understand MSUD.

  11. Large Voids in the Universe are Really Empty

    Science.gov (United States)

    1996-07-01

    . The reason is that matter may `hide' from the astronomers' view by not forming any stars. If so, matter could exist in a form that is not visible with a telescope. For the present investigation, the team of astronomers used a completely different method to detect matter in the local universe. They set out by measuring the speed with which over 2000 well known galaxies move through space, by means of radio and optical telescopes around the world. From galaxy velocities to mass density ESO astronomers Luiz da Costa and Wolfram Freudling then developed a computer program which determines, from such measurements, how the matter is distributed in the corresponding region of space. The technique is essentially to check which distribution of matter will best reproduce the observed galaxy velocities. For this, the programme relies only on the universal law of gravitation. As the end product, it delivers a simulated three-dimensional image of the distribution of all matter present, i.e. including otherwise invisible matter, if there is any. Looking at the resulting map of the matter distribution, the ESO astronomers found several voids without any matter at all. This result was so surprising that both of them spent several months carefully checking all parts of their complex computer programme. Only after thorough tests confirmed the initial finding did they decide to present the outcome of this work. This trailblazing result will now be published in an article in the September 1, 1996, issue of the Astrophysical Journal Letters (Vol. 468, p. 5). ESO Press Photo 32/96 that accompanies this Press Release is an example of a `cut' through the local region of space. The Milky Way galaxy in which we live is at the centre. Empty voids, as well as regions with excess mass, for instance the `Great Attractor' that is known from earlier studies, are clearly seen. So where is the matter? How can there be such large empty regions? And how do they arise? These are fundamental questions

  12. Void formation in ODS EUROFER produced by hot isostatic pressing

    Energy Technology Data Exchange (ETDEWEB)

    Ortega, Y.; Monge, M.A.; Munoz, A.; Leguey, T.; Pareja, R. [Madrid Univ. Carlos-3, Dept. de Fisica (Spain); Castro, V. de [Oxford Univ., Dept. of Materials (United Kingdom)

    2007-07-01

    for positrons trapped in voids. Unmilled EUROFER and the EUROFER plate did not show this behavior attributed to the formation of voids induced by annealing. The results indicate that the milling damage retained in the HIPed material has the capability to cluster into voids and growth by heating. These voids appear to be stable upon annealing 1323 K. (authors)

  13. Roles of Polyuria and Hyperglycemia on Bladder Dysfunction in Diabetes

    Science.gov (United States)

    Xiao, Nan; Wang, Zhiping; Huang, Yexiang; Daneshgari, Firouz; Liu, Guiming

    2014-01-01

    Purpose Diabetes mellitus (DM) causes diabetic bladder dysfunction (DBD). We aimed to identify the pathogenic roles of polyuria and hyperglycemia on DBD in rats. Materials and Methods Seventy-two female Sprague-Dawley rats were divided: age-matched controls (control), sham urinary diversion (sham), urinary diversion (UD), streptozotocin-induced diabetes after sham UD (DM), streptozotocin-induced diabetes after UD (UD+DM), and 5% sucrose-induced diuresis after sham UD (DIU). UD was performed by ureterovaginostomy 10d before DM induction. Animals were evaluated 20 wks after DM or diuresis induction. We measured 24-hr drinking and voiding volumes and cystometry (CMG). Bladders were harvested for quantification of smooth muscle, urothelium, and collagen. We measured nitrotyrosine and manganese superoxide dismutase (MnSOD) in bladder. Results Diabetes and diuresis caused increases in drinking volume, voiding volume and bladder weight. Bladder weights decreased in the UD and UD+DM groups. Intercontractile intervals, voided volume, and compliance increased in the DIU and DM groups, decreased in the UD, and further decreased in the UD+DM group. The total cross-sectional tissue, smooth muscle and urothelium areas increased in the DIU and DM groups, and decreased in the UD and UD+DM groups. As percentages of total tissue area, collagen decreased in the DIU and DM groups, and increased in the UD and UD+DM groups, and smooth muscle and urothelium decreased in the UD and UD+DM groups. Nitrotyrosine and MnSOD increased in DM and UD+DM rats. Conclusions Polyuria induced bladder hypertrophy, while hyperglycemia induced substantial oxidative stress in the bladder, which may play a pathogenic role in late stage DBD. PMID:22999997

  14. Percutaneous transluminal angioplasty for Brescia-Cimino hemodialysis fistula dysfunction: technical success rate, patency rate and factors that influence the results

    Energy Technology Data Exchange (ETDEWEB)

    Maeda, Kiyosumi [Department of Radiology, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu-city, Shiga 520-2192 (Japan)]. E-mail: kiyosumi@belle.shiga-med.ac.jp; Furukawa, Akira [Department of Radiology, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu-city, Shiga 520-2192 (Japan); Yamasaki, Michio [Department of Radiology, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu-city, Shiga 520-2192 (Japan); Murata, Kiyoshi [Department of Radiology, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu-city, Shiga 520-2192 (Japan)

    2005-06-01

    Objective: To evaluate the initial clinical success and long-term patency rates of percutaneous transluminal angioplasty (PTA) using a venous approach for dysfunctional Brescia-Cimino fistula and to identify factors that may affect initial success and long-term patency. Materials and methods: A total of 99 PTA procedures were performed in retrograde fassion for 60 mature Brescia-Cimino shunts with dysfunction caused by anastomotic or peripheral outflow vein stenosis or occlusion. The initial clinical success rates were compared between stenosis and occlusion using Fisher's exact test. The Kaplan-Meier method was used to calculate the primary and secondary cumulative patency rates, and the log-rank test was used for comparison. Relative risks of patency loss according to clinical characteristics were determined with multivariate Cox models. Results: The initial clinical success rate of all interventions was 92%, and the rates for stenosis and occlusion were 99 and 65%, respectively (P < 0.0001). The primary and secondary cumulative patency rates for fistulas (excluding initial failure) at 12 months were 53 and 84%, respectively. The relative risks were 5.2 (P 0.004) for longer lesions and 4.5 (P = 0.007) for younger fistulas. The primary cumulative patency rate of four patients with a younger fistula and a longer stenosis at 4 months was 0%. Conclusion: Favorable primary and secondary cumulative patency rates are obtained in most patients. Long lesion length and younger age of fistulas were the two factors that reduced the patency rate after PTA.

  15. The Void Galaxy Survey: Star Formation Properties

    CERN Document Server

    Beygu, B; van der Hulst, J M; Jarrett, T H; Peletier, R; van de Weygaert, R; van Gorkom, J H; Aragon-Calvo, M A

    2016-01-01

    We study the star formation properties of 59 void galaxies as part of the Void Galaxy Survey (VGS). Current star formation rates are derived from $\\rm{H\\alpha}$ and recent star formation rates from near-UV imaging. In addition, infrared 3.4 $\\rm{\\mu m}$, 4.6 $\\rm{\\mu m}$, 12 $\\rm{\\mu m}$ and 22 $\\rm{\\mu m}$ WISE emission is used as star formation and mass indicator. Infrared and optical colours show that the VGS sample displays a wide range of dust and metallicity properties. We combine these measurements with stellar and HI masses to measure the specific SFRs ($\\rm{SFR/M_{*}}$) and star formation efficiencies ($\\rm{SFR/M_{HI}}$). We compare the star formation properties of our sample with galaxies in the more moderate density regions of the cosmic web, 'the field'. We find that specific SFRs of the VGS galaxies as a function of stellar and HI mass are similar to those of the galaxies in these field regions. Their $\\rm{SFR\\alpha}$ is slightly elevated than the galaxies in the field for a given total HI mass. ...

  16. Properties of galaxy halos in Clusters and Voids

    CERN Document Server

    Antonuccio-Delogu, V; Pagliaro, A; Van Kampen, E; Colafrancesco, Sergio; Germaná, A; Gambera, M

    2000-01-01

    We use the results of a high resolution N-body simulation to investigate the role of the environment on the formation and evolution of galaxy-sized halos. Starting from a set of constrained initial conditions, we have produced a final configuration hosting a double cluster in one octant and a large void extending over two octants of the simulation box. In this paper we concentrate on {\\em gravitationally bound} galaxy-sized halos extracted from the two regions. Exploiting the high mass resolution of our simulation ($m_{body} = 2.1\\times 10^{9} h^{-1} M_{\\odot}$), we focus on halos with a relatively small mass: $5\\times 10^{10} \\leq M \\leq 2\\times 10^{12} M_{\\odot}$. We present results for two statistics: the relationship between 1-D velocity dispersion and mass and the probability distribution of the spin parameter $P(\\lambda)$. We do find a clear difference between halos lying in overdense regions and in voids. The \\svm relationship is well described by the Truncated Isothermal Sphere (TIS) model introduced ...

  17. Erectile dysfunction

    African Journals Online (AJOL)

    that increase blood flow to the penis. The blood ... The pressure of the blood in the chambers makes the ... What are the risk factors for erectile dysfunction? The most .... losing excessive weight and increasing physical activity, may improve the ...

  18. ''The Incubation Period for Void Swelling and its Dependence on Temperature, Dose Rate, and Dislocation Structure Evolution''

    Energy Technology Data Exchange (ETDEWEB)

    Surh, M P; Sturgeon, J B; Wolfer, W G

    2002-06-13

    Void swelling in structural materials used for nuclear reactors is characterized by an incubation period whose duration largely determines the usefulness of the material for core components. Significant evolution of the dislocation and void microstructures that control radiation-induced swelling can occur during this period. Thus, a theory of incubation must treat time-dependent void nucleation in combination with dislocation evolution, in which the sink strengths of voids and dislocations change in concert. We present theoretical results for void nucleation and growth including the time-dependent, self-consistent coupling of point defect concentrations to the evolution of both void populations and dislocation density. Simulations show that the incubation radiation dose is a strong function of the starting dislocation density and of the dislocation bias factors for vacancy and interstitial absorption. Irradiation dose rate and temperature also affect the duration of incubation. The results are in general agreement with experiment for high purity metals.

  19. Ductile damage of porous materials with two populations of voids

    Science.gov (United States)

    Vincent, Pierre-Guy; Monerie, Yann; Suquet, Pierre

    2008-01-01

    This study is devoted to the modelling of ductile damage in uranium dioxide. This polycrystalline material contains two populations of voids of well separated size. The problem addressed here is the prediction of the effective flow surface of a Gurson material containing randomly oriented oblate voids. The case of spherical voids is considered first and the variational approach of Gurson is generalized by adding a compressible component to his original velocity field. The case of aligned oblate voids is then considered and a suitable generalization of a velocity field due to Gologanu et al. (ASME J. Engrg. Mater. Technol. 116 (1994) 290-297) is proposed. The extension to randomly oriented voids is achieved by averaging over all orientations. In each case, rigorous upper bounds and approximate estimates are derived and compared (in the case of spherical voids) with Finite Element simulations. To cite this article: P.-G. Vincent et al., C. R. Mecanique 336 (2008).

  20. Voids and the Cosmic Web: cosmic depressions & spatial complexity

    CERN Document Server

    van de Weygaert, Rien

    2016-01-01

    Voids form a prominent aspect of the Megaparsec distribution of galaxies and matter. Not only do they represent a key constituent of the Cosmic Web, they also are one of the cleanest probes and measures of global cosmological parameters. The shape and evolution of voids are highly sensitive to the nature of dark energy, while their substructure and galaxy population provides a direct key to the nature of dark matter. Also, the pristine environment of void interiors is an important testing ground for our understanding of environmental influences on galaxy formation and evolution. In this paper, we review the key aspects of the structure and dynamics of voids, with a particular focus on the hierarchical evolution of the void population. We demonstrate how the rich structural pattern of the Cosmic Web is related to the complex evolution and buildup of voids.

  1. Void alignment and density profile applied to measuring cosmological parameters

    CERN Document Server

    Dai, De-Chang

    2015-01-01

    We study the orientation and density profiles of the cosmological voids with SDSS10 data. Using voids to test Alcock-Paczynski effect has been proposed and tested in both simulations and actual SDSS data. Previous observations imply that there exist an empirical stretching factor which plays an important role in the voids' orientation. Simulations indicate that this empirical stretching factor is caused by the void galaxies' peculiar velocities. Recently Hamaus et al. found that voids' density profiles are universal and their average velocities satisfy linear theory very well. In this article we first confirm that the stretching effect exists using independent analysis. We then apply the universal density profile to measure the cosmological parameters. We find that the void density profile can be a tool to measure the cosmological parameters.

  2. Numerical study of photon migration in the presence of a void region using the radiative transfer and diffusion equations

    Science.gov (United States)

    Miyakawa, Erina; Fujii, Hiroyuki; Hattori, Kiyohito; Tatekura, Yuki; Kobayashi, Kazumichi; Watanabe, Masao

    2016-12-01

    Diffuse optical tomography (DOT), which is still under development, has a potential to enable non-invasive diagnoses of thyroid cancers in the human neck using the near-infrared light. This modality needs a photon migration model because scattered light is used. There are two types of photon migration models: the radiative transport equation (RTE) and diffusion equation (DE). The RTE can describe photon migration in the human neck with accuracy, while the DE enables an efficient calculation. For developing the accurate and efficient model of photon migration, it is crucial to investigate a condition where the DE holds in a scattering medium including a void region under the refractive-index mismatch at the void boundary because the human neck has a trachea (void region) and the refractive indices are different between the human neck and trachea. Hence, in this paper, we compare photon migration using the RTE with that using the DE in the medium. The numerical results show that the DE is valid under the refractive-index match at the void boundary even though the void region is near the source and detector positions. Under the refractive-index mismatch at the boundary, the numerical results using the DE disagree with those using the RTE when the void region is near the source and detector positions. This is probably because the anisotropy of the light scattering remains around the void boundary.

  3. Void lattice formation in electron irradiated CaF{sub 2}: Statistical analysis of experimental data and cellular automata simulations

    Energy Technology Data Exchange (ETDEWEB)

    Zvejnieks, G., E-mail: guntars@latnet.lv; Merzlyakov, P.; Kuzovkov, V.N.; Kotomin, E.A.

    2016-02-01

    Calcium fluoride (CaF{sub 2}) is an important optical material widely used in both microlithography and deep UV windows. It is known that under certain conditions electron beam irradiation can create therein a superlattice consisting of vacancy clusters (called a void lattice). The goal of this paper is twofold. Firstly, to perform a quantitative analysis of experimental TEM images demonstrating void lattice formation, we developed two distinct image filters. As a result, we can easily calculate vacancy concentration, vacancy cluster distribution function as well as average distances between defect clusters. The results for two suggested filters are similar and demonstrate that experimental void cluster growth is accompanied by a slight increase of the void lattice constant. Secondly, we proposed a microscopic model that allows us to reproduce a macroscopic void ordering, in agreement with experimental data, and to resolve existing theoretical and experimental contradictions. Our computer simulations demonstrate that macroscopic void lattice self-organization can occur only in a narrow parameter range. Moreover, we studied the kinetics of a void lattice ordering, starting from an initial disordered stage, in a good agreement with the TEM experimental data.

  4. On the linearity of tracer bias around voids

    CERN Document Server

    Pollina, Giorgia; Dolag, Klaus; Weller, Jochen; Baldi, Marco; Moscardini, Lauro

    2016-01-01

    The large-scale structure of the universe can only be observed directly via luminous tracers of the underlying distribution of dark matter. However, the clustering statistics of tracers are biased and depend on various properties of the tracers themselves, such as their host-halo mass and formation and assembly history. On very large scales, where density fluctuations are within the linear regime, this tracer bias results in a constant offset in the clustering amplitude, which is known as linear bias. Towards smaller non-linear scales, this is no longer the case and tracer bias becomes a complicated function of scale and time. We focus on tracer bias centered on cosmic voids, depressions of the density field that spatially dominate the universe. We consider three different types of tracers: galaxies, galaxy clusters and AGNs, extracted from the hydrodynamical simulation suite Magneticum Pathfinder. In contrast to common clustering statistics that focus on the auto-correlation of tracers, we find that void-tra...

  5. An observational detection of the bridge effect of void filaments

    CERN Document Server

    Shim, Junsup; Hoyle, Fiona

    2015-01-01

    The bridge effect of void filaments is a phrase coined by Park & Lee (2009b) to explain the correlations found in a numerical experiment between the luminosity of the void galaxies and the degree of the straightness of their host filaments. Their numerical finding implies that a straight void filament provides a narrow channel for the efficient transportation of gas and matter particles from the surroundings into the void galaxies. To observationally confirm the presence of the bridge effect of void filaments, we identify the filamentary structures from the Sloan void catalog and determine the specific size of each void filament as a measure of its straightness. Using both classical and Bayesian statistics, we indeed detect a strong tendency that the void galaxies located in the more straight filaments are on average more luminous, which is in agreement with the numerical prediction. It is also shown that the strength of correlation increases with the spatial extent of the void filaments, which can be phy...

  6. The sparkling Universe: a scenario for cosmic void motions

    CERN Document Server

    Ceccarelli, Laura; Lares, Marcelo; Paz, Dante J; Maldonado, Victoria E; Luparello, Heliana E; Lambas, Diego Garcia

    2015-01-01

    We perform a statistical study of the global motion of cosmic voids using both a numerical simulation and observational data. We analyse their relation to large--scale mass flows and the physical effects that drive those motions. We analyse the bulk motions of voids, defined by the mean velocity of haloes in the surrounding shells in the numerical simulation, and by galaxies in the Sloan Digital Sky Survey Data Release 7. We find void mean bulk velocities close to 400 km/s, comparable to those of haloes (~ 500-600 km/s), depending on void size and the large--scale environment. Statistically, small voids move faster than large ones, and voids in relatively higher density environments have higher bulk velocities than those placed in large underdense regions. Also, we analyze the mean mass density around voids finding, as expected, large--scale overdensities (underdensities) along (opposite to) the void motion direction, suggesting that void motions respond to a pull--push mechanism. This contrasts with massive ...

  7. A New Void Fraction Measurement Method for Gas-Liquid Two-Phase Flow in Small Channels

    Directory of Open Access Journals (Sweden)

    Huajun Li

    2016-01-01

    Full Text Available Based on a laser diode, a 12 × 6 photodiode array sensor, and machine learning techniques, a new void fraction measurement method for gas-liquid two-phase flow in small channels is proposed. To overcome the influence of flow pattern on the void fraction measurement, the flow pattern of the two-phase flow is firstly identified by Fisher Discriminant Analysis (FDA. Then, according to the identification result, a relevant void fraction measurement model which is developed by Support Vector Machine (SVM is selected to implement the void fraction measurement. A void fraction measurement system for the two-phase flow is developed and experiments are carried out in four different small channels. Four typical flow patterns (including bubble flow, slug flow, stratified flow and annular flow are investigated. The experimental results show that the development of the measurement system is successful. The proposed void fraction measurement method is effective and the void fraction measurement accuracy is satisfactory. Compared with the conventional laser measurement systems using standard laser sources, the developed measurement system has the advantages of low cost and simple structure. Compared with the conventional void fraction measurement methods, the proposed method overcomes the influence of flow pattern on the void fraction measurement. This work also provides a good example of using low-cost laser diode as a competent replacement of the expensive standard laser source and hence implementing the parameter measurement of gas-liquid two-phase flow. The research results can be a useful reference for other researchers’ works.

  8. Trends in Toilet Training and Voiding Habits among Children with Down Syndrome.

    Science.gov (United States)

    Powers, Mary K; Brown, Elizabeth T; Hogan, Ross M; Martin, Aaron D; Ortenberg, Joseph; Roth, Christopher C

    2015-09-01

    Children with Down syndrome are at risk for lower urinary tract dysfunction and delayed toilet training. Comparative studies regarding voiding function in the Down syndrome population are lacking. We assessed urinary continence and voiding function in patients with Down syndrome and a control group. A questionnaire designed to assess toilet training, continence status, symptoms of lower urinary tract dysfunction and prior evaluation of urological complaints was sent to parents of 326 children with Down syndrome who had been seen at our institution previously. The same survey was administered to parents of patients without Down syndrome. Data were compiled, and descriptive and comparative statistical analyses were performed. A total of 77 patients comprised the Down syndrome group and 78 patients without Down syndrome comprised the control group. Average age of reported toilet training completion was 5.5 years in children with Down syndrome and 2.2 years in controls. Of children 5 years or older 79% with Down syndrome were toilet trained, compared to 100% of those without Down syndrome. Incontinence was reported in 46% of previously toilet trained children with Down syndrome and 24.5% of controls. These findings were statistically significant. No significant difference was observed in the rate of urinary tract infection, symptoms of lower urinary tract dysfunction or evaluation for urological complaints. Children with Down syndrome can experience marked delay in toilet training and are more likely to suffer incontinence afterward. This study was ineffective in determining whether symptoms of lower urinary tract dysfunction could be related to decreased continence rates. Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  9. Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice.

    Science.gov (United States)

    Villar, Van Anthony M; Jones, John Edward; Armando, Ines; Asico, Laureano D; Escano, Crisanto S; Lee, Hewang; Wang, Xiaoyan; Yang, Yu; Pascua-Crusan, Annabelle M; Palmes-Saloma, Cynthia P; Felder, Robin A; Jose, Pedro A

    2013-01-04

    The peripheral dopaminergic system plays a crucial role in blood pressure regulation through its actions on renal hemodynamics and epithelial ion transport. The dopamine D5 receptor (D(5)R) interacts with sorting nexin 1 (SNX1), a protein involved in receptor retrieval from the trans-Golgi network. In this report, we elucidated the spatial, temporal, and functional significance of this interaction in human renal proximal tubule cells and HEK293 cells stably expressing human D(5)R and in mice. Silencing of SNX1 expression via RNAi resulted in the failure of D(5)R to internalize and bind GTP, blunting of the agonist-induced increase in cAMP production and decrease in sodium transport, and up-regulation of angiotensin II receptor expression, of which expression was previously shown to be negatively regulated by D(5)R. Moreover, siRNA-mediated depletion of renal SNX1 in C57BL/6J and BALB/cJ mice resulted in increased blood pressure and blunted natriuretic response to agonist in salt-loaded BALB/cJ mice. These data demonstrate a crucial role for SNX1 in D(5)R trafficking and that SNX1 depletion results in D(5)R dysfunction and thus may represent a novel mechanism for the pathogenesis of essential hypertension.

  10. Contemporary analysis of erectile, voiding, and oncologic outcomes following primary targeted cryoablation of the prostate for clinically localized prostate cancer

    Directory of Open Access Journals (Sweden)

    Christopher J. Diblasio

    2008-08-01

    Full Text Available PURPOSE: To evaluate erectile function (EF and voiding function following primary targeted cryoablation of the prostate (TCAP for clinically localized prostate cancer (CaP in a contemporary cohort. MATERIALS AND METHODS: We retrospectively reviewed all patients treated between 2/2000-5/2006 with primary TCAP. Variables included age, Gleason sum, pre-TCAP prostate specific antigen (PSA, prostate volume, clinical stage, pre-TCAP hormonal ablation, pre-TCAP EF and American Urologic Association Symptom Score (AUASS. EF was recorded as follows: 1 = potent; 2 = sufficient for intercourse; 3 = partial/insufficient; 4 = minimal/insufficient; 5 = none. Voiding function was analyzed by comparing pre/post-TCAP AUASS. Statistical analysis utilized SAS software with p < 0.05 considered significant. RESULTS: After exclusions, 78 consecutive patients were analyzed with a mean age of 69.2 years and follow-up 39.8 months. Thirty-five (44.9% men reported pre-TCAP EF level of 1-2. Post-TCAP, 9 of 35 (25.7% regained EF of level 1-2 while 1 (2.9% achieved level 3 EF. Median pre-TCAP AUASS was 8.75 versus 7.50 postoperatively (p = 0.39. Six patients (7.7% experienced post-TCAP urinary incontinence. Lower pre-TCAP PSA (p = 0.008 and higher Gleason sum (p = 0.002 were associated with higher post-TCAP AUASS while prostate volume demonstrated a trend (p = 0.07. Post-TCAP EF and stable AUASS were not associated with increased disease-recurrence (p = 0.24 and p = 0.67, respectively. CONCLUSIONS: Stable voiding function was observed post-TCAP, with an overall incontinence rate of 7.7%. Further, though erectile dysfunction is common following TCAP, 25.7% of previously potent patients demonstrated erections suitable for intercourse. While long-term data is requisite, consideration should be made for prospective evaluation of penile rehabilitation following primary TCAP.

  11. Influences of physical properties of two-phase mixture on void fraction in an annular vessel

    Institute of Scientific and Technical Information of China (English)

    LI Xiao-Ming; BI Qin-Cheng; FENG Quan-Ke; CHEN Ting-Kuan; DU She-Jiao

    2004-01-01

    To keep the void fraction of two-phase hydrogen in the moderator cell of the cold neutron source (CNS)of China Advanced Research Reactor (CARR) to a specified range, an annular vessel with the same size as the actual moderator cell was used as test section. Deionized water and alcohol, sucrose, and sodium chloride solutions with different concentrations were used as working fluid to find out influences of physical properties, such as density, viscosity and surface tension, of the two-phase mixture on void fraction. The tests proved that the ratio of surface tension to density of liquid phase has great influence on void fraction: the larger the ratio, the smaller the void fraction.Since the ratio of surface tension to density of Freon 113 is lower than that of liquid hydrogen, Freon 113 can be used as a working fluid to study the void fraction in the two-phase hydrogen thermosiphon loop in the CNS of CARR and the results will be conservative.

  12. A possible cold imprint of voids on the microwave background radiation

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Yan-Chuan; Cole, Shaun; Frenk, Carlos S. [Institute for Computational Cosmology, Department of Physics, University of Durham, South Road, Durham DH1 3LE (United Kingdom); Neyrinck, Mark C. [Department of Physics and Astronomy, The Johns Hopkins University, 3701 San Martin Drive, Baltimore, MD 21218 (United States); Szapudi, István, E-mail: y.c.cai@durham.ac.uk [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States)

    2014-05-10

    We measure the average temperature decrement on the cosmic microwave background (CMB) produced by voids selected in the Sloan Digital Sky Survey Data Release 7 spectroscopic redshift galaxy catalog, spanning redshifts 0 < z < 0.44. We find an imprint amplitude between 2.6 and 2.9 μK as viewed through a compensated top-hat filter scaled to the radius of each void, we assess the statistical significance of the imprint at ∼2σ, and we make crucial use of N-body simulations to calibrate our analysis. As expected, we find that large voids produce cold spots on the CMB through the integrated Sachs-Wolfe (ISW) effect. However, we also find that small voids in the halo density field produce hot spots, because they reside in contracting, larger-scale overdense regions. This is an important effect to consider when stacking CMB imprints from voids of different radii. We have found that the same filter radius that gives the largest ISW signal in simulations also yields close to the largest detected signal in the observations. However, although it is low in significance, our measured signal has a much higher amplitude than expected from ISW in the concordance ΛCDM universe. The discrepancy is also at the ∼2σ level. We have demonstrated that our result is robust against the varying of thresholds over a wide range.

  13. DIVE in the cosmic web: voids with Delaunay Triangulation from discrete matter tracer distributions

    CERN Document Server

    Zhao, Cheng; Liang, Yu; Kitaura, Francisco-Shu; Chuang, Chia-Hsun

    2015-01-01

    We present a novel parameter-free cosmological void finder (\\textsc{dive}, Delaunay TrIangulation Void findEr) based on Delaunay Triangulation (DT), which efficiently computes the empty spheres constrained by a discrete set of tracers. We define the spheres as DT voids, and describe their properties, including an universal density profile together with an intrinsic scatter. We apply this technique on 100 halo catalogues with volumes of 2.5\\,$h^{-1}$Gpc side each, with a bias and number density similar to the BOSS CMASS Luminous Red Galaxies, performed with the \\textsc{patchy} code. Our results show that there are two main species of DT voids, which can be characterised by the radius: they have different responses to halo redshift space distortions, to number density of tracers, and reside in different dark matter environments. Based on dynamical arguments using the tidal field tensor, we demonstrate that large DT voids are hosted in expanding regions, whereas the haloes used to construct them reside in collap...

  14. Investigations of void formation in neutron irradiated iron and F82H steel

    DEFF Research Database (Denmark)

    Eldrup, Morten Mostgaard; Singh, Bachu Narain

    2002-01-01

    In the present work pure iron and low activation steel F82H have been neutron irradiated at temperatures in the interval 50 deg.C - 350 deg.C to a dose of 0.23 dpa (displacements per atom). The formation of defects has been investigated by the use ofpositron annihilation spectroscopy (PAS......). In addition iron has been irradiated to different doses in the range 0.01 - 0.4 dpa at 50oC and 100oC and the dose dependence of the electrical conductivity determined. The results demonstrated that theformation of voids takes place during neutron irradiation of pure iron in the whole temperature range....... For irradiation temperatures of 50 deg.C and 100 deg.C also a high density of micro-voids was observed. Voids and micro-voids were also detected in lowactivation F82H steel for a low irradiation temperature (50 deg.C), while for irradiation close to the temperature of annealing stage V (250 deg.C), no voids...

  15. Searching for Dwarf H Alpha Emission-line Galaxies within Voids III: First Spectra

    Science.gov (United States)

    Moody, J. Ward; Draper, Christian; McNeil, Stephen; Joner, Michael D.

    2017-02-01

    The presence or absence of dwarf galaxies with {M}r\\prime > -14 in low-density voids is determined by the nature of dark matter halos. To better understand what this nature is, we are conducting an imaging survey through redshifted Hα filters to look for emission-line dwarf galaxies in the centers of two nearby galaxy voids called FN2 and FN8. Either finding such dwarfs or establishing that they are not present is a significant result. As an important step in establishing the robustness of the search technique, we have observed six candidates from the survey of FN8 with the Gillett Gemini telescope and GMOS spectrometer. All of these candidates had emission, although none was Hα. The emission in two objects was the [O iii]λ4959, 5007 doublet plus Hβ, and the emission in the remaining four was the [O ii]λ3727 doublet, all from objects beyond the void. While no objects were within the void, these spectra show that the survey is capable of finding emission-line dwarfs in the void centers that are as faint as {M}r\\prime ˜ -12.4, should they be present. These spectra also show that redshifts estimated from our filtered images are accurate to several hundred km s-1 if the line is identified correctly, encouraging further work in finding ways to conduct redshift surveys through imaging alone.

  16. A study of process induced voids in resistance welding of thermoplastic composites

    OpenAIRE

    Shi, H.; Fernandez Villegas, I.; Bersee, H.E.N.

    2015-01-01

    Void formation in resistance welding of woven fabric reinforced thermoplastic composites was investigated. Void contents were measured using optical microscopy and digital image process. Un-even void distributions were observed in the joints, and more voids were found in the middle of the joints than the edges. A higher welding pressure was shown to help reduce the void generation. The mechanisms of void formation, in particular fibre de-compaction induced voids and residual moisture induced ...

  17. Effect of stress-triaxiality on void growth in dynamic fracture of metals: a molecular dynamics study

    Energy Technology Data Exchange (ETDEWEB)

    Seppala, E T; Belak, J; Rudd, R E

    2003-10-07

    The effect of stress-triaxiality on growth of a void in a three dimensional single-crystal face-centered-cubic (FCC) lattice has been studied. Molecular dynamics (MD) simulations using an embedded-atom (EAM) potential for copper have been performed at room temperature and using strain controlling with high strain rates ranging from 10{sup 7}/sec to 10{sup 10}/sec. Strain-rates of these magnitudes can be studied experimentally, e.g. using shock waves induced by laser ablation. Void growth has been simulated in three different conditions, namely uniaxial, biaxial, and triaxial expansion. The response of the system in the three cases have been compared in terms of the void growth rate, the detailed void shape evolution, and the stress-strain behavior including the development of plastic strain. Also macroscopic observables as plastic work and porosity have been computed from the atomistic level. The stress thresholds for void growth are found to be comparable with spall strength values determined by dynamic fracture experiments. The conventional macroscopic assumption that the mean plastic strain results from the growth of the void is validated. The evolution of the system in the uniaxial case is found to exhibit four different regimes: elastic expansion; plastic yielding, when the mean stress is nearly constant, but the stress-triaxiality increases rapidly together with exponential growth of the void; saturation of the stress-triaxiality; and finally the failure.

  18. Effect of the Entrained Air Void on Strength and Interfacial Transition Zone of Air-Entrained Mortar

    Institute of Scientific and Technical Information of China (English)

    GAO Hui; ZHANG Xiong; ZHANG Yongjuan

    2015-01-01

    In order to facilitate the development and application of air entraining agents (AEA) in the high performance concrete, entrained air void structure parameters (air void size range from 10 to 1 600 μm) of 28 d sifted mortar were measured by image analysis method. The relationship between the air void size distribution and strength of mortar was studied by methods of grey connection analysis and multiple linear regression analysis. The multiple linear regression equation was established with a correlation coefifcient of 0.966. The weight of the affection of hierarchical porosity on the compressive strength ratio was also obtained. In addition, the effect of air voids on the paste-aggregate interfacial transition zone (ITZ) was analyzed by microhardness. The results show that the correlation between different pore size range and the compressive strength is negative. The effect of air void size distribution on 28 days compressive strength is different: under the condition of similar total porosity, with the increase of the porosity of the air void size, ranging from 10 to 200 μm, and the decrease of the porosity, ranging from 200 to 1 600 μm, the average air void diameter and mean free spacing are decreased; as well as the width of ITZ. On the contrary, the microhardness of the ITZ is increased while the compressive strength loss is decreased.

  19. Behaviour of voids in a shear field

    DEFF Research Database (Denmark)

    Tvergaard, Viggo

    2009-01-01

    to a plane connecting the ends of the micro-crack is used as an approximate representation of contact stresses during frictionless sliding. In a previous study of the same problem the author applied hydrostatic pressure inside the nearly closed micro-crack to approximate contact conditions. The transverse...... surface loads used in the present analyses avoid the tendency to unrealistically elongate the voids. It is found that even though the model applied here gives significantly later occurrence of a maximum overall shear stress than that found by using hydrostatic pressure, the present model does predict...... a maximum in all the cases analyzed and thus illustrates the micro-mechanism leading to failure of the material by localization of plastic flow....

  20. Void-induced dissolution in molecular dynamics simulations of NaCl and water.

    Science.gov (United States)

    Bahadur, Ranjit; Russell, Lynn M; Alavi, Saman; Martin, Scot T; Buseck, Peter R

    2006-04-21

    To gain a better understanding of the interaction of water and NaCl at the surface during dissolution, we have used molecular dynamics to simulate the interface with two equal-sized slabs of solid NaCl and liquid water in contact. The introduction of voids in the bulk of the salt, as well as steps or pits on the surface of the NaCl slab results in a qualitative change of system structure, as defined by radial distribution functions (RDFs). As an example, the characteristic Na-Na RDF for the system changes from regularly spaced narrow peaks (corresponding to an ordered crystalline structure), to a broad primary and smaller secondary peak (corresponding to a disordered structure). The change is observed at computationally short time scales of 100 ps, in contrast with a much longer time scale of 1 mus expected for complete mixing in the absence of defects. The void fraction (which combines both bulk and surface defects) required to trigger dissolution varies between 15%-20% at 300 K and 1 atm, and has distinct characteristics for the physical breakdown of the crystal lattice. The void fraction required decreases with temperature. Sensitivity studies show a strong dependence of the critical void fraction on the quantity and distribution of voids on the surface, with systems containing a balanced number of surface defects and a rough surface showing a maximum tendency to dissolve. There is a moderate dependence on temperature, with a 5% decrease in required void fraction with a 100 K increase in temperature, and a weak dependence on water potential model used, with the SPC, SPC/E, TIP4P, and RPOL models giving qualitatively identical results. The results were insensitive to the total quantity of water available for dissolution and the duration of the simulation.

  1. Void-induced dissolution in molecular dynamics simulations of NaCl and water

    Science.gov (United States)

    Bahadur, Ranjit; Russell, Lynn M.; Alavi, Saman; Martin, Scot T.; Buseck, Peter R.

    2006-04-01

    To gain a better understanding of the interaction of water and NaCl at the surface during dissolution, we have used molecular dynamics to simulate the interface with two equal-sized slabs of solid NaCl and liquid water in contact. The introduction of voids in the bulk of the salt, as well as steps or pits on the surface of the NaCl slab results in a qualitative change of system structure, as defined by radial distribution functions (RDFs). As an example, the characteristic Na-Na RDF for the system changes from regularly spaced narrow peaks (corresponding to an ordered crystalline structure), to a broad primary and smaller secondary peak (corresponding to a disordered structure). The change is observed at computationally short time scales of 100ps, in contrast with a much longer time scale of 1μs expected for complete mixing in the absence of defects. The void fraction (which combines both bulk and surface defects) required to trigger dissolution varies between 15%-20% at 300K and 1atm, and has distinct characteristics for the physical breakdown of the crystal lattice. The void fraction required decreases with temperature. Sensitivity studies show a strong dependence of the critical void fraction on the quantity and distribution of voids on the surface, with systems containing a balanced number of surface defects and a rough surface showing a maximum tendency to dissolve. There is a moderate dependence on temperature, with a 5% decrease in required void fraction with a 100K increase in temperature, and a weak dependance on water potential model used, with the SPC, SPC/E, TIP4P, and RPOL models giving qualitatively identical results. The results were insensitive to the total quantity of water available for dissolution and the duration of the simulation.

  2. Influence of the austenitic stainless steel microstructure on the void swelling under ion irradiation

    Directory of Open Access Journals (Sweden)

    Rouxel Baptiste

    2016-01-01

    Full Text Available To understand the role of different metallurgical parameters on the void formation mechanisms, various austenitic stainless steels were elaborated and irradiated with heavy ions. Two alloys, in several metallurgical conditions (15Cr/15Ni–Ti and 15Cr/25Ni–Ti, were irradiated in the JANNUS-Saclay facility at 600 °C with 2 MeV Fe2+ ions up to 150 dpa. Resulting microstructures were observed by Transmission Electron Microscopy (TEM. Different effects on void swelling are highlighted. Only the pre-aged samples, which were consequently solute and especially titanium depleted, show cavities. The nickel-enriched matrix shows more voids with a smaller size. Finally, the presence of nano-precipitates combined with a dense dislocation network decreases strongly the number of cavities.

  3. Detection of underground voids in Tahura Japan Cave Bandung using ground penetrating radar

    Science.gov (United States)

    Azimmah, Azizatun; Widodo

    2017-07-01

    The detection of underground voids is important due to their effects on subsidence higher risk. Ground Penetrating Radar is one of geophysical electromagnetic methods that has been proven to be able to detect and locate any void beneath the surface effectively at a shallow depth. This method uses the contrasts of dielectric properties, resistivity and magnetic permeability to investigate and map what lies beneath the surface. Hence, this research focused on how GPR could be applied for detecting underground voids at the site of investigation, The Japan Cave in Taman Hutan Raya located in Dago, Bandung, Indonesia. A 100 MHz GPR shielded antenna frequency were used to measure three >80 meters long measurement lines. These three GPR profiles were positioned on the surface above the Japan Cave. The radargram results showed existences of different amplitude regions proven to be the air-filled cavities, at a depth of <10 meters, and interfaces between the underneath layers.

  4. Cell type-dependent induction of DNA damage by 1800 MHz radiofrequency electromagnetic fields does not result in significant cellular dysfunctions.

    Directory of Open Access Journals (Sweden)

    Shanshan Xu

    Full Text Available BACKGROUND: Although IARC clarifies radiofrequency electromagnetic fields (RF-EMF as possible human carcinogen, the debate on its health impact continues due to the inconsistent results. Genotoxic effect has been considered as a golden standard to determine if an environmental factor is a carcinogen, but the currently available data for RF-EMF remain controversial. As an environmental stimulus, the effect of RF-EMF on cellular DNA may be subtle. Therefore, more sensitive method and systematic research strategy are warranted to evaluate its genotoxicity. OBJECTIVES: To determine whether RF-EMF does induce DNA damage and if the effect is cell-type dependent by adopting a more sensitive method γH2AX foci formation; and to investigate the biological consequences if RF-EMF does increase γH2AX foci formation. METHODS: Six different types of cells were intermittently exposed to GSM 1800 MHz RF-EMF at a specific absorption rate of 3.0 W/kg for 1 h or 24 h, then subjected to immunostaining with anti-γH2AX antibody. The biological consequences in γH2AX-elevated cell type were further explored with comet and TUNEL assays, flow cytometry, and cell growth assay. RESULTS: Exposure to RF-EMF for 24 h significantly induced γH2AX foci formation in Chinese hamster lung cells and Human skin fibroblasts (HSFs, but not the other cells. However, RF-EMF-elevated γH2AX foci formation in HSF cells did not result in detectable DNA fragmentation, sustainable cell cycle arrest, cell proliferation or viability change. RF-EMF exposure slightly but not significantly increased the cellular ROS level. CONCLUSIONS: RF-EMF induces DNA damage in a cell type-dependent manner, but the elevated γH2AX foci formation in HSF cells does not result in significant cellular dysfunctions.

  5. Measuring the growth rate of structure around cosmic voids

    Science.gov (United States)

    Hawken, A. J.; Michelett, D.; Granett, B.; Iovino, A.; Guzzo, L.

    2016-10-01

    Using an algorithm based on searching for empty spheres we identified 245 voids in the VIMOS Public Extragalactic Redshift Survey (VIPERS). We show how by modelling the anisotropic void-galaxy cross correlation function we can probe the growth rate of structure.

  6. An Interacting Galaxy System along a Filament in a Void

    NARCIS (Netherlands)

    Beygu, B.; Kreckel, K.; van de Weijgaert, R.; van der Hulst, J. M.; van Gorkom, J. H.

    2013-01-01

    Cosmological voids provide a unique environment for the study of galaxy formation and evolution. The galaxy population in their interiors has properties significantly different from average field galaxies. As part of our Void Galaxy Survey (VGS), we have found a system of three interacting galaxies

  7. A Cosmic Void Catalog of SDSS DR12 BOSS Galaxies

    CERN Document Server

    Mao, Qingqing; Scherrer, Robert J; Scoccimarro, Roman; Tinker, Jeremy L; McBride, Cameron K; Neyrinck, Mark C; Schneider, Donald P; Pan, Kaike; Bizyaev, Dmitry; Malanushenko, Elena; Malanushenko, Viktor

    2016-01-01

    We present a cosmic void catalog using the large-scale structure galaxy catalog from the Baryon Oscillation Spectroscopic Survey (BOSS). This galaxy catalog is part of the Sloan Digital Sky Survey (SDSS) Data Release 12 and is the final catalog of SDSS-III. We take into account the survey boundaries, masks, and angular and radial selection functions, and apply the ZOBOV void finding algorithm to the galaxy catalog. After making quality cuts to ensure that the voids represent real underdense regions, we identify 1228 voids with effective radii spanning the range 20-100Mpc/h and with central densities that are, on average, 30% of the mean sample density. We discuss the basic statistics of voids, such as their size and redshift distributions, and measure the radial density profile of the voids via a stacking technique. In addition, we construct mock void catalogs from 1000 mock galaxy catalogs, and find that the properties of BOSS voids are in good agreement with those in the mock catalogs. We compare the stella...

  8. Tensor anisotropy as a tracer of cosmic voids

    CERN Document Server

    Bustamante, Sebastian

    2015-01-01

    We present a new method to find voids in cosmological simulations based on the tidal and the velocity shear tensors definitions of the cosmic web. We use the fractional anisotropy (FA) computed from the eigenvalues of each web scheme as a void tracer. We identify voids using a watershed transform based on the local minima of the FA field without making any assumption on the shape or structure of the voids. We test the method on the Bolshoi simulation and report on the abundance and radial averaged profiles for the density, velocity and fractional anisotropy. We find that voids in the velocity shear web are smaller than voids in the tidal web, with a particular overabundance of very small voids in the inner region of filaments/sheets. We classify voids as subcompensated/overcompansated depending on the absence/presence of an overdense matter ridge in their density profile, finding that close to $65\\%$ and $35\\%$ of the total population are classified into each category, respectively. Finally, we find evidence ...

  9. Voided stain on paper method for analysis of mouse urination.

    Science.gov (United States)

    Sugino, Y; Kanematsu, A; Hayashi, Y; Haga, H; Yoshimura, N; Yoshimura, K; Ogawa, O

    2008-01-01

    To evaluate the usefulness of a quantification method using filter paper for analyzing minute voided urine of the mouse. Voided stain on paper (VSOP) method; the correlation between area of stained spot on a filter paper and amount of applied liquid was calculated. Voiding behavior of the mice was analyzed by placing the animal above the same filter paper and recording voided time and area over 2 hr. The usefulness of the VSOP method was tested in analysis of the voiding behavior of five female 7-week-old ddY mice treated with cyclophosphamide (CPM, 150 mg/kg, intraperitoneally) and five control ones, in comparison with the histology of CPM-induced cystitis. Further, the voided volume of male and female ddY mouse ranging from 2 to 13 weeks was assessed. There was a linear correlation between liquid volume and stained area on the filter paper (y = 16.472x - 22.411, R(2) = 0.9981). Between control mice and those with histologically proven CPM cystitis, there was a significant difference in voided volume (362.7 +/- 51.9 and 127.8 +/- 100.0 microl, VSOP method is a useful tool for evaluating voiding behavior of the mouse, including those with small bladder capacity.

  10. Voids and the Cosmic Web: cosmic depression & spatial complexity

    NARCIS (Netherlands)

    van de Weygaert, Rien; Shandarin, S.; Saar, E.; Einasto, J.

    2016-01-01

    Voids form a prominent aspect of the Megaparsec distribution of galaxies and matter. Not only do theyrepresent a key constituent of the Cosmic Web, they also are one of the cleanest probesand measures of global cosmological parameters. The shape and evolution of voids are highly sensitive tothe natu

  11. STRESS CONCENTRATION DUE TO A SPHERICAL VOID UNDER HERTZIAN CONTACT

    Directory of Open Access Journals (Sweden)

    Stelian ALACI,

    2010-06-01

    Full Text Available The present paper presents the method of estimating the stress concentrator effect of a spherical void from an elastic half-space. An essential part consists in estimation of FEM error by finding the contact pressure from half-plane using an analytical method. Next, the stress concentrator effect of the same void, except for placed into elastic space, is found.

  12. High gain durable anti-reflective coating with oblate voids

    Energy Technology Data Exchange (ETDEWEB)

    Maghsoodi, Sina; Brophy, Brenor L.; Colson, Thomas E.; Gonsalves, Peter R.; Abrams, Ze' ev

    2016-06-28

    Disclosed herein are single layer transparent coatings with an anti-reflective property, a hydrophobic property, and that are highly abrasion resistant. The single layer transparent coatings contain a plurality of oblate voids. At least 1% of the oblate voids are open to a surface of the single layer transparent coatings.

  13. The Aspen-Amsterdam void finder comparison project

    NARCIS (Netherlands)

    Colberg, Joerg M.; Pearce, Frazer; Foster, Caroline; Platen, Erwin; Brunino, Riccardo; Neyrinck, Mark; Basilakos, Spyros; Fairall, Anthony; Feldman, Hume; Gottloeber, Stefan; Hahn, Oliver; Hoyle, Fiona; Mueller, Volker; Nelson, Lorne; Plionis, Manolis; Porciani, Cristiano; Shandarin, Sergei; Vogeley, Michael S.; van de Weygaert, Rien

    2008-01-01

    Despite a history that dates back at least a quarter of a century, studies of voids in the large-scale structure of the Universe are bedevilled by a major problem: there exist a large number of quite different void-finding algorithms, a fact that has so far got in the way of groups comparing their

  14. Warmth Elevating the Depths: Shallower Voids with Warm Dark Matter

    CERN Document Server

    Yang, Lin F; Aragon-Calvo, Miguel A; Silk, Joseph

    2014-01-01

    Warm dark matter (WDM) has been proposed as an alternative to cold dark matter (CDM), to resolve issues such as the apparent lack of satellites around the Milky Way. Even if WDM is not the answer to observational issues, it is essential to constrain the nature of the dark matter. The effect of WDM on haloes has been extensively studied, but the small-scale initial smoothing in WDM also affects the present-day cosmic web and voids. It suppresses the cosmic "sub-web" inside voids, and the formation of both void haloes and subvoids. In N-body simulations run with different assumed WDM masses, we identify voids with the zobov algorithm, and cosmic-web components with the origami algorithm. As dark-matter warmth increases, the initial-conditions smoothing increases, and the number of voids and subvoids is suppressed. Also, void density profiles change, their shapes become flatter inside the void radius, while edges of the voids remain unchanged. Also, filaments and walls become cleaner, as the sub-structures in be...

  15. A void coalescence model for combined tension and shear

    Science.gov (United States)

    Butcher, C.; Chen, Z. T.

    2009-03-01

    The influence of shear loading on damage development in Gurson-based models has long been neglected resulting in inadequate fracture strain predictions at low triaxiality where shear effects become significant. The plastic limit-load fracture criterion used in advanced Gurson models neglects the influence of shear loading and overestimates the fracture strain and porosity at low triaxiality. In this paper, we extend the recently proposed shear damage model of Xue [1] to provide a stronger physical foundation by removing the simplifying assumptions. Then we directly modify the plastic limit-load fracture criterion by coupling with the extended shear damage model to account for shear weakening and failure of the intervoid ligament in void coalescence. We apply the modified plastic limit-load criterion to predict the necking of sheet tensile specimens and find very good agreement with the available experimental results.

  16. Dislocation and void segregation in copper during neutron irradiation

    DEFF Research Database (Denmark)

    Singh, Bachu Narain; Leffers, Torben; Horsewell, Andy

    1986-01-01

    High-purity (99. 999%) and fully annealed copper specimens have been irradiated in the DR-3 reactor at Riso to doses of 1 multiplied by 10**2**2 and 5 multiplied by 10**2**2 neutrons (fast)m** minus **2(2 multiplied by 10** minus **3 dpa and 1 multiplied by 10** minus **2 dpa, respectively...... were distributed between these walls. The dislocation walls were practically free of voids and generally had a void-denuded zone along them. The density of dislocations (loops and segments) was very low in the region containing voids (i. e. between the dislocation walls). Even with this low dislocation...... density, the void swelling rate was very high (approximately 2. 5% per dpa). The implications of the segregated distribution of sinks for void formation and growth are briefly discussed....

  17. Alignment of galaxy spins in the vicinity of voids

    CERN Document Server

    Slosar, Anze

    2008-01-01

    We provide limits on the alignment of galaxy orientations with the direction to the void center for galaxies lying near the edges of voids. We locate spherical voids in volume limited samples of galaxies from the Sloan Digital Sky Survey using the HB inspired void finder and investigate the orientation of (color selected) spiral galaxies that are nearly edge-on or face-on. In contrast with previous literature, we find no statistical evidence for departure from random orientations. Expressed in terms of the parameter c, introduced by Lee & Pen to describe the strength of such an alignment, we find that c<0.11(0.13) at 95% (99.7%) confidence limit within a context of a toy model that assumes a perfectly spherical voids with sharp boundaries.

  18. Two new methods to detect cosmic voids without density measurements

    CERN Document Server

    Elyiv, Andrii; Pollina, Giorgia; Baldi, Marco; Branchini, Enzo; Cimatti, Andrea; Moscardini, Lauro

    2014-01-01

    Cosmic voids are effective cosmological probes to discriminate among competing world models. Their precise and unbiased identification is a prerequisite to perform accurate observational tests. The identification is generally based on density or geometry criteria that, because of their very nature, are prone to shot noise errors. In this work we propose two new void finders that are based on dynamical and clustering criteria to select voids in the Lagrangian coordinates and minimise the impact of sparse sampling. The first approach exploits the Zeldovich approximation to trace back in time the orbits of galaxies located in the voids and their surroundings, whereas the second uses the observed galaxy-galaxy correlation function to relax the objects' spatial distribution to homogeneity and isotropy. In both cases voids are defined as regions of the negative velocity divergence in Lagrangian coordinates, that can be regarded as sinks of the back-in-time streamlines of the mass tracers. To assess the performance ...

  19. The cosmic web in CosmoGrid void regions

    Science.gov (United States)

    Rieder, Steven; van de Weygaert, Rien; Cautun, Marius; Beygu, Burcu; Portegies Zwart, Simon

    2016-10-01

    We study the formation and evolution of the cosmic web, using the high-resolution CosmoGrid ΛCDM simulation. In particular, we investigate the evolution of the large-scale structure around void halo groups, and compare this to observations of the VGS-31 galaxy group, which consists of three interacting galaxies inside a large void. The structure around such haloes shows a great deal of tenuous structure, with most of such systems being embedded in intra-void filaments and walls. We use the Nexus+} algorithm to detect walls and filaments in CosmoGrid, and find them to be present and detectable at every scale. The void regions embed tenuous walls, which in turn embed tenuous filaments. We hypothesize that the void galaxy group of VGS-31 formed in such an environment.

  20. Voids and the Cosmic Web: cosmic depression & spatial complexity

    Science.gov (United States)

    van de Weygaert, Rien

    2016-10-01

    Voids form a prominent aspect of the Megaparsec distribution of galaxies and matter. Not only do theyrepresent a key constituent of the Cosmic Web, they also are one of the cleanest probesand measures of global cosmological parameters. The shape and evolution of voids are highly sensitive tothe nature of dark energy, while their substructure and galaxy population provides a direct key to thenature of dark matter. Also, the pristine environment of void interiors is an important testing groundfor our understanding of environmental influences on galaxy formation and evolution. In this paper, we reviewthe key aspects of the structure and dynamics ofvoids, with a particular focus on the hierarchical evolution of the void population. We demonstratehow the rich structural pattern of the Cosmic Web is related to the complex evolution and buildupof voids.

  1. Cell type-dependent induction of DNA damage by 1800 MHz radiofrequency electromagnetic fields does not result in significant cellular dysfunctions.

    Science.gov (United States)

    Xu, Shanshan; Chen, Guangdi; Chen, Chunjing; Sun, Chuan; Zhang, Danying; Murbach, Manuel; Kuster, Niels; Zeng, Qunli; Xu, Zhengping

    2013-01-01

    Although IARC clarifies radiofrequency electromagnetic fields (RF-EMF) as possible human carcinogen, the debate on its health impact continues due to the inconsistent results. Genotoxic effect has been considered as a golden standard to determine if an environmental factor is a carcinogen, but the currently available data for RF-EMF remain controversial. As an environmental stimulus, the effect of RF-EMF on cellular DNA may be subtle. Therefore, more sensitive method and systematic research strategy are warranted to evaluate its genotoxicity. To determine whether RF-EMF does induce DNA damage and if the effect is cell-type dependent by adopting a more sensitive method γH2AX foci formation; and to investigate the biological consequences if RF-EMF does increase γH2AX foci formation. Six different types of cells were intermittently exposed to GSM 1800 MHz RF-EMF at a specific absorption rate of 3.0 W/kg for 1 h or 24 h, then subjected to immunostaining with anti-γH2AX antibody. The biological consequences in γH2AX-elevated cell type were further explored with comet and TUNEL assays, flow cytometry, and cell growth assay. Exposure to RF-EMF for 24 h significantly induced γH2AX foci formation in Chinese hamster lung cells and Human skin fibroblasts (HSFs), but not the other cells. However, RF-EMF-elevated γH2AX foci formation in HSF cells did not result in detectable DNA fragmentation, sustainable cell cycle arrest, cell proliferation or viability change. RF-EMF exposure slightly but not significantly increased the cellular ROS level. RF-EMF induces DNA damage in a cell type-dependent manner, but the elevated γH2AX foci formation in HSF cells does not result in significant cellular dysfunctions.

  2. Taylor-plasticity-based analysis of length scale effects in void growth

    KAUST Repository

    Liu, Junxian

    2014-09-25

    We have studied the void growth problem by employing the Taylor-based strain gradient plasticity theories, from which we have chosen the following three, namely, the mechanism-based strain gradient (MSG) plasticity (Gao et al 1999 J. Mech. Phys. Solids 47 1239, Huang et al 2000 J. Mech. Phys. Solids 48 99-128), the Taylor-based nonlocal theory (TNT; 2001 Gao and Huang 2001 Int. J. Solids Struct. 38 2615) and the conventional theory of MSG (CMSG; Huang et al 2004 Int. J. Plast. 20 753). We have addressed the following three issues which occur when plastic deformation at the void surface is unconstrained. (1) Effects of elastic deformation. Elasticity is essential for cavitation instability. It is therefore important to guarantee that the gradient term entering the Taylor model is the effective plastic strain gradient instead of the total strain gradient. We propose a simple elastic-plastic decomposition method. When the void size approaches the minimum allowable initial void size related to the maximum allowable geometrically necessary dislocation density, overestimation of the flow stress due to the negligence of the elastic strain gradient is on the order of lεY/R0 near the void surface, where l, εY and R0 are, respectively, the intrinsic material length scale, the yield strain and the initial void radius. (2) MSG intrinsic inconsistency, which was initially mentioned in Gao et al (1999 J. Mech. Phys. Solids 47 1239) but has not been the topic of follow-up studies. We realize that MSG higher-order stress arises due to the linear-strain-field approximation within the mesoscale cell with a nonzero size, lε. Simple analysis shows that within an MSG mesoscale cell near the void surface, the difference between microscale and mesoscale strains is on the order of (lε/R0)2, indicating that when lε/R0 ∼ 1.0, the higher-order stress effect can make the MSG result considerably different from the TNT or CMSG results. (3) Critical condition for cavitation instability

  3. New insights into systemic sclerosis related microcirculatory dysfunction by assessment of sublingual micr\\ocirculation and vascular glycocalyx layer. Results from a preliminary study.

    Science.gov (United States)

    Miranda, S; Armengol, G; Le Besnerais, M; Lévesque, H; Benhamou, Y

    2015-05-01

    Initial morphological and functional markers of systemic sclerosis (SSc) are evidenced in microvascular structural damage. However, nailfold videocapillaroscopy (NVC) explores only morphological abnormalities. Sidestream Dark Field (SDF) imaging of sublingual microcirculation enables assessment of both morphological and functional capillary impairment and allows measurement of the glycocalyx layer, which is an indicator of endothelial dysfunction. To describe and validate sublingual abnormalities assessed by SDF device in comparison with NVC findings and to measure the thickness of the glycocalyx layer. From February to May 2014, 26 subjects (16 SSc patients and 10 healthy controls) underwent standardised NVC and SDF imaging of sublingual microcirculation. Glycocalyx thickness was also measured. Capillary density and percentage of perfused vessels were significantly reduced in patients with SSc (n = 13) compared to controls. Correlation between nailfold capillary density assessed by NVC and sublingual capillary density assessed by SDF was observed (r(2) = 0.59; P = 0.023). According to the NVC pattern, patients with "active" disease experienced greater reduction in capillary density than patients with "late" disease as suggested by the de Backer score (9.17 ± 0.81 vs 10.86 ± 1.19; P = 0.03). Additionally, the decrease in glycocalyx thickness was measured in SSc patients (n = 13) compared to controls (n = 10) (0.41 ± 0.03 versus 0.76 ± 0.29 P = 0.003). Our results suggest for the first time in SSc, that sublingual microcirculation and glycocalyx are impaired and that SDF imaging findings correlate with those of NVC. Nevertheless, further studies are required for the validation of our preliminary results. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. Treatment of Thyroid Dysfunctions Decreases the Risk of Cerebrovascular Events in Men but Not in Women: Results of the MONICA/KORA Cohort Study.

    Directory of Open Access Journals (Sweden)

    Julia Six-Merker

    Full Text Available Thyroid disorders are well known to be associated with cardiovascular diseases. Some studies have shown that the negative effects of thyroid disorders are partially reversible after adequate treatment. The aim of this analysis was to assess the risk of incident ischemic cerebrovascular diseases in study participants treated for thyroid dysfunctions in a population-based cohort study.For the presented analyses data from 8564 male and 8714 female individuals aged 25 to 74 years of the MONICA/KORA cohort were used (median follow-up 14.0 years. A combined binary variable "thyroid disorder" (TDC was created utilizing data on self-reported physician-treated thyroid disorders and information about medication use. To examine the association between TDC and incident ischemic cerebrovascular events, we performed multiple adjusted Cox proportional hazard regression models and calculated hazard ratios and corresponding 95% confidence intervals (HR, 95%CI.During follow-up between 1984 and 2008/2009, 514 incident fatal and non-fatal ischemic cerebrovascular events occurred in men and 323 in women. At baseline, 3.5% of men and 15.6% of women reported TDC. In the fully adjusted model, males who reported TDC had a significantly reduced risk of ischemic cerebrovascular events (HR = 0.52, 95%CI = 0.29-0.92. A similar result was obtained in men, when we utilized information on thyroid hormones use only. For the total study population and for women with TDC we found no association with ischemic cerebrovascular events.In our longitudinal analyses subjects with treated thyroid diseases had no increased risk of incident ischemic cerebrovascular events. Surprisingly in males, even a significantly reduced risk of incident ischemic cerebrovascular events was found, a result that deserves further clarification.

  5. Study on void fraction distribution in the moderator cell of Cold Neutron Source systems in China Advanced Research Reactor

    Science.gov (United States)

    Li, Liangxing; Li, Huixiong; Hu, Jinfeng; Bi, Qincheng; Chen, Tingkuan

    2007-04-01

    A physical model is developed for analyzing and evaluating the void fraction profiles in the moderator cell of the Cold Neutron Source (CNS) of the China Advanced Research Reactor (CARR), which is now constructing in the China Institute of Atomic Energy (CIAE). The results derived from the model are compared with the related experimental data and its propriety is verified. The model is then used to explore the influence of various factors, including the diameter of boiling vapor bubbles, liquid density, liquid viscosity and the total heating power acted on the moderator cell, on the void fraction profiles in the cell. The results calculated with the present model indicate that the void fraction in the moderator cell increases linearly with heating power, and increases with the liquid viscosity, but decreases as the size of bubbles increases, and increases linearly with heating power. For the case where hydrogen is being used as a moderator, calculation results show that the void fraction in the moderator cell may be less than 30%, which is the maximum void fraction permitted from the nuclear physics point of view. The model and the calculation results will help to obtain insight of the mechanism that controls the void fraction distribution in the moderator cell, and provide theoretical supports for the moderator cell design.

  6. Vacancy Migration and Void Formation in gamma-irradiated Ice

    DEFF Research Database (Denmark)

    Eldrup, Morten Mostgaard

    1976-01-01

    are ascribed to Ps inhibition and conversion by radiation created OH radicals. Heating above −165°C makes both effects disappear in agreement with radiation chemistry results on OH. Heating also increases the longest lifetime up to 11 nsec at −130°C. This is explained as vacancy migration leading to void......Positron annihilation techniques (PAT) have been used to study the effects in ice of γ irradiation at −196°C and of subsequent heating, both in poly‐ and monocrystalline samples. The main effects of irradiation are (1) the appearance in positron lifetime spectra of two long‐lived components (1...... formation. A vacancy migration energy is obtained, Em=0.34±0.07 eV, around three times higher than the previously assumed value. The advantage in this kind of study of using PAT, which are specifically sensitive to vacancy type defects, is pointed out....

  7. Biology of Sexual Dysfunction

    Directory of Open Access Journals (Sweden)

    Anil Kumar Mysore Nagaraj

    2009-05-01

    Full Text Available Sexual activity is a multifaceted activity, involving complex interactions between the nervous system, the endocrine system, the vascular system and a variety of structures that are instrumental in sexual excitement, intercourse and satisfaction. Sexual function has three components i.e., desire, arousal and orgasm. Many sexual dysfunctions can be categorized according to the phase of sexual response that is affected. In actual clinical practice however, sexual desire, arousal and orgasmic difficulties more often than not coexist, suggesting an integration of phases. Sexual dysfunction can result from a wide variety of psychological and physiological causes including derangements in the levels of sex hormones and neurotrensmitters. This review deals with the biology of different phases of sexual function as well as implications of hormones and neurotransmitters in sexual dysfunction

  8. Detection of underground voids in Ohio by use of geophysical methods

    Science.gov (United States)

    Munk, Jens; Sheets, R.A.

    1997-01-01

    Geophysical methods are generally classified as electrical, potential field, and seismic methods. Each method type relies on contrasts of physical properties in the subsurface. Forward models based on the physical properties of air- and water-filled voids within common geologic materials indicate that several geophysical methods are technically feasible for detection of subsurface voids in Ohio, but ease of use and interpretation varies widely between the methods. Ground-penetrating radar is the most rapid and cost-effective method for collection of subsurface data in areas associated with voids under roadways. Electrical resistivity, gravity, or seismic reflection methods have applications for direct delineation of voids, but data-collection and analytical procedures are more time consuming. Electrical resistivity, electromagnetic, or magnetic methods may be useful in locating areas where conductive material, such as rail lines, are present in abandoned underground coal mines. Other electrical methods include spontaneous potential and very low frequency (VLF); these latter two methods are considered unlikely candidates for locating underground voids in Ohio. Results of ground-penetrating radar surveys at three highway sites indicate that subsurface penetration varies widely with geologic material type and amount of cultural interference. Two highway sites were chosen over abandoned underground coal mines in eastern Ohio. A third site in western Ohio was chosen in an area known to be underlain by naturally occurring voids in lime stone. Ground-penetrating radar surveys at Interstate 470, in Belmont County, Ohio, indicate subsurface penetration of less than 15 feet over a mined coal seam that was known to vary in depth from 0 to 40 feet. Although no direct observations of voids were made, anomalous areas that may be related to collapse structures above voids were indicated. Cultural interference dominated the radar records at Interstate 70, Guernsey County, Ohio

  9. Properties of hydrogen induced voids in silicon

    Energy Technology Data Exchange (ETDEWEB)

    Weber, J; Fischer, T; Hieckmann, E; Hiller, M; Lavrov, E V [Institute for Applied Physics/Semiconductor Physics, TU Dresden, 01062 Dresden (Germany)

    2005-06-08

    After heat treatment, silicon samples implanted with high doses of hydrogen exhibit blistering and defoliation of thin silicon layers. The process is used commercially in the fabrication of thin silicon-on-insulator layers (Smart Cut(registered)). In the present study we investigate the behaviour of hydrogen after different processing steps, which lead to thin Si layers bonded to glass substrates. A set of hydrogen implanted samples is studied by means of low temperature photoluminescence, Raman spectroscopy, x-ray diffraction and optical microscopy (visible and infrared). The formation of Si-H bonds is detected after implantation together with a build-up of internal strain. After annealing, the relaxation of the implanted layers is found to be connected with the formation of hydrogen saturated vacancies and the formation of H{sub 2} molecules filling up larger voids. A comparison is made with hydrogen plasma treated samples, where well defined platelets on {l_brace}111{r_brace} planes are found to trap hydrogen molecules. No direct evidence of the role of {l_brace}111{r_brace} and {l_brace}100{r_brace} platelets in the blistering process is found in the implanted layers from our study. We determine considerable compressive stresses in the bonded Si layers on glass substrates. The photoluminescence is strongly enhanced in these bonded layers but red-shifted due to a strain reduced band gap.

  10. Tibolone and transdermal E-2/NETA for the treatment of female sexual dysfunction in naturally menopausal women : Results of a randomized active-controlled trial

    NARCIS (Netherlands)

    Nijland, Esme A.; Schultz, Willibrord C. M. Weijmar; Nathorst-Boos, Jorgen; Helmond, Frans A.; Van Lunsen, Rik H. W.; Palacios, Santiago; Norman, Robert J.; Mulder, Roel J.; Davis, Susan R.

    2008-01-01

    Introduction. There are some data to suggest that tibolone improves sexual function in postmenopausal women. However, evidence about the effects of tibolone on female sexual dysfunction is lacking. Aim. To compare the efficacy on sexual function of tibolone 2.5 mg to continuous combined transdermal

  11. Tibolone and transdermal E-2/NETA for the treatment of female sexual dysfunction in naturally menopausal women : Results of a randomized active-controlled trial

    NARCIS (Netherlands)

    Nijland, Esme A.; Schultz, Willibrord C. M. Weijmar; Nathorst-Boos, Jorgen; Helmond, Frans A.; Van Lunsen, Rik H. W.; Palacios, Santiago; Norman, Robert J.; Mulder, Roel J.; Davis, Susan R.

    Introduction. There are some data to suggest that tibolone improves sexual function in postmenopausal women. However, evidence about the effects of tibolone on female sexual dysfunction is lacking. Aim. To compare the efficacy on sexual function of tibolone 2.5 mg to continuous combined transdermal

  12. Partial discharge patterns and surface deterioration in voids in filled and unfilled epoxy

    DEFF Research Database (Denmark)

    Holbøll, Joachim; Henriksen, Mogens

    1992-01-01

    Results are presented from analyses of pulses from partial discharges (PDs) in single spherical voids in filled and unfilled epoxy plastic and related to the observed surface deterioration. The filler types used were dolomite, alumina, and silica. Long-time aging tests including pulse phase...

  13. JURIDICAL IMPLICATIONS OF THE LEGAL NORM VOID OF INTERFAITH MARRIAGES IN INDONESIA

    Directory of Open Access Journals (Sweden)

    Kadek Wiwik Indrayanti

    2017-03-01

    Consequently, the juridical implications of interfaith marriage legal norm void give rise to the judges’ differing interpretations which are unfavorable to interfaith couples. The validity of these marriages cannot be accomplished, resulting in the marriages to be deemed invalid, implicating the status and position of women and children as well as heritance issues.

  14. Comparative assessment of the area of sealer voids in single cone obturation done with mineral trioxide aggregate, epoxy resin, and zinc-oxide eugenol based sealers

    Directory of Open Access Journals (Sweden)

    Anisha Kumar

    2016-01-01

    Full Text Available Introduction: Voids in the sealer mass have the potential to allow leakage through obturation. They are more critical in single cone (SC obturation as the volume of sealer used in this obturation is larger when compared to other obturations. Aim: To compare the area of voids in mineral trioxide aggregate (MTA-based, resin-based, and zinc oxide-eugenol-based sealers when employed with SC obturation technique. Materials and Methods: Fifteen teeth were cleaned and shaped and divided into three groups for SC obturation using MTA Fillapex, AH26, and Pulpdent sealers, respectively. The obturated teeth were sectioned at apical, middle, and coronal third, and area of voids in the sealer was assessed using a stereomicroscope and digital images and image software. The results were statistically analyzed using SPSS software and Kruskal-Wallis and Mann-Whitney tests. Results: The three tested sealers showed voids in all the sections except MTA Fillapex, which was void free in apical and middle sections. There were significant differences between these sealers regarding their section wise area of voids (P < 0.05. Similarly, there were significant differences in their overall area of voids (P < 0.05 with MTA Fillapex showing significantly least area of voids followed by AH26. Conclusions: SC obturation with MTA Fillapex sealer, which showed void free apical and middle third sections, had significantly least area of voids in the sealer followed by the one with AH26 sealer, whereas SC obturation with Pulpdent sealer had significantly most area of voids.

  15. Measuring Baryon Acoustic Oscillations from the clustering of voids

    CERN Document Server

    Liang, Yu; Chuang, Chia-Hsun; Kitaura, Francisco-Shu; Tao, Charling

    2015-01-01

    We investigate the necessary methodology to optimally measure the baryon acoustic oscillation (BAO) signal, from voids based on galaxy redshift catalogues. To this end, we study the dependency of the BAO signal on the population of voids classified by their sizes. We find for the first time the characteristic features of the correlation function of voids including the first robust detection of BAOs in mock galaxy catalogues. These show an anti-correlation around the scale corresponding to the smallest size of voids in the sample (the void exclusion effect), and dips at both sides of the BAO peak, which can be used to determine the significance of the BAO signal without any priori model. Furthermore, our analysis demonstrates that there is a scale dependent bias for different populations of voids depending on the radius, with the peculiar property that the void population with the largest BAO significance corresponds to tracers with approximately zero bias on the largest scales. We further investigate the meth...

  16. A variational void coalescence model for ductile metals

    KAUST Repository

    Siddiq, Amir

    2011-08-17

    We present a variational void coalescence model that includes all the essential ingredients of failure in ductile porous metals. The model is an extension of the variational void growth model by Weinberg et al. (Comput Mech 37:142-152, 2006). The extended model contains all the deformation phases in ductile porous materials, i.e. elastic deformation, plastic deformation including deviatoric and volumetric (void growth) plasticity followed by damage initiation and evolution due to void coalescence. Parametric studies have been performed to assess the model\\'s dependence on the different input parameters. The model is then validated against uniaxial loading experiments for different materials. We finally show the model\\'s ability to predict the damage mechanisms and fracture surface profile of a notched round bar under tension as observed in experiments. © Springer-Verlag 2011.

  17. Evolution of shock through a void in foam

    Science.gov (United States)

    Kim, Y.; Smidt, J. M.; Murphy, T. J.; Douglass, M. R.; Devolder, B. G.; Fincke, J. R.; Schmidt, D. W.; Cardenas, T.; Newman, S. G.; Hamilton, C. E.; Sedillo, T. J.; Los Alamos, NM 87544 Team

    2016-10-01

    Marble implosion is an experimental campaign intended to study the effects of heterogeneous mix on fusion burn. A spherical capsule is composed of deuterated plastic foam of controlled pore (or void) size with tritium fill in pores. As capsule implosion evolves, the initially separated deuterium and tritium will mix, producing DT yields. Void evolution during implosion is of interest for the Marble campaign. A shock tube, driven by the laser at Omega, was designed to study the evolution of a shock through a foam-filled ``void'' and subsequent void evolution. Targets were comprised of a 100 mg/cc CH foam tube containing a 200-µm diameter, lower density doped foam sphere. High-quality, radiographic images were obtained from both 2% iodine-doped in plastic foam and 15% tin-doped in aerogel foam. These experiments will be used to inform simulations.

  18. Measurement and Analysis of Sodium Void Reactivity Effect in CEFR

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The sodium void reactivity effect (SVRE) is one of the important parameters in the design and safety analysis of sodium-cooled fast reactors. In some serious accident conditions, for example the total instantaneous blockage (TIB) accident,

  19. Diagnostic value of symptoms and clean-voided urine specimen in childhood urinary tract infection.

    Science.gov (United States)

    Pylkkänen, J; Vilska, J; Koskimies, O

    1979-05-01

    In diagnosing urinary tract infection (UTI) the symptoms of 477 infants and children and the findings in their clean-voided urine specimens were evaluated. 322 patients were considered infected, when a bacterial culture of suprapubic aspirate was used as a diagnostic reference. No diagnosis was attempted on the basis of symptoms only. Numerous bacteria or greater than or equal to 200 leuc./mm3 in an uncentrifuged clean-voided urine specimen or greater than or equal to 10(5) bact./ml in quantitative bacterial culture were found in 59%, 42% and 81% of the infected symptomatic patients. The diagnostic accuracies of these indices were 88%, 94% and 95%, respectively. In asymptomatic patients the accuracies were considerably lower. Among these infected patients normal or equivocal isolated findings in the clean-voided urine specimens were frequently seen, and could not markedly be reduced by the various related factors, such as technique of urine collection, urine specific gravity or pH of urine. None of the above mentioned indices of the clean-voided urine specimens seems to be alone accurate and sensitive enough for diagnosing UTI, and therefore these should be used in combination. The advantage of immediately obtaining results supports the use of urine microscopy as a primary diagnostic method in symptomatic UTI of childhood in particular.

  20. Experiments on Void Fraction of CO2 Flow Boiling in a Horizontal Micro-fin Tube

    Science.gov (United States)

    Kondou, Chieko; Higashiiue, Shinya; Kuwahara, Ken; Koyama, Shigeru

    This paper deals with an experimental investigation on the void fraction of CO2 flow boiling in a horizontal micro-fin tube. The mean void fraction in the insulated 400 mm length sampling section, which is located next to the test evaporator, has measured by the quick closing valve method. The experimental data have been obtained in mass flux range of 200 to 455 kg/(m2s) and the refrigerant pressure range of 3.5 to 5.0 MPa. It is confirmed that the relation between void fraction and quality is affected by both mass flux and pressure. The experimental results are also compared with two previous correlations for horizontal smooth tubes, which are proposed by Butterworth and Smith. The present data satisfactorily agreed with Butterworth's correlation in the range of quality from 0.03 to 0.99. However, Smith's correlation is found to predict slightly higher than present data. As a trial, the empirical correlation of void fraction, based on the experimental slip ratios, is proposed.

  1. EDOVE: Energy and Depth Variance-Based Opportunistic Void Avoidance Scheme for Underwater Acoustic Sensor Networks.

    Science.gov (United States)

    Bouk, Safdar Hussain; Ahmed, Syed Hassan; Park, Kyung-Joon; Eun, Yongsoon

    2017-09-26

    Underwater Acoustic Sensor Network (UASN) comes with intrinsic constraints because it is deployed in the aquatic environment and uses the acoustic signals to communicate. The examples of those constraints are long propagation delay, very limited bandwidth, high energy cost for transmission, very high signal attenuation, costly deployment and battery replacement, and so forth. Therefore, the routing schemes for UASN must take into account those characteristics to achieve energy fairness, avoid energy holes, and improve the network lifetime. The depth based forwarding schemes in literature use node's depth information to forward data towards the sink. They minimize the data packet duplication by employing the holding time strategy. However, to avoid void holes in the network, they use two hop node proximity information. In this paper, we propose the Energy and Depth variance-based Opportunistic Void avoidance (EDOVE) scheme to gain energy balancing and void avoidance in the network. EDOVE considers not only the depth parameter, but also the normalized residual energy of the one-hop nodes and the normalized depth variance of the second hop neighbors. Hence, it avoids the void regions as well as balances the network energy and increases the network lifetime. The simulation results show that the EDOVE gains more than 15 % packet delivery ratio, propagates 50 % less copies of data packet, consumes less energy, and has more lifetime than the state of the art forwarding schemes.

  2. Grain boundary void nucleation in astroloy produced by room temperature deformation and anneal

    Science.gov (United States)

    Saegusa, T.; Uemura, M.; Weertman, J. R.

    1980-08-01

    Dyson and co-workers have shown that the creep life of a nickel base superalloy can be greatly shortened if the material is strained at room temperature before the creep test is carried out. They found that a prestrain followed by a short annealing time produces small grain boundary cavities, and it is the presence of these prenucleated voids which so seriously degrades service life at elevated temperatures. The present work explores the relationship between microstructure and prestrain void nucleation. Samples of the nickel base superalloy astroloy were given various heat treatments which led to significantly different microstructures. It was found that voids resulting from a prestrain-anneal treatment form preferentially at the ends of carbides on grain boundaries oriented roughly parallel to the prestrain tensile axis or rolling direction. Void spacing in the various microstructures is proportional to (but larger than) carbide spacing. The growth of these cavities during annealing is attributed to the presence of tensile residual stresses arising from the difference in deformability between grain boundary regions and the relatively soft matrix.

  3. Modeling the soil water retention properties of same-textured soils with different initial void ratios

    Science.gov (United States)

    Tan, Fang; Zhou, Wan-Huan; Yuen, Ka-Veng

    2016-11-01

    This study presents a method of predicting the soil water retention curve (SWRC) of a soil using a set of measured SWRC data from a soil with the same texture but different initial void ratio. The relationships of the volumetric water contents and the matric suctions between two samples with different initial void ratios are established. An adjustment parameter (β) is introduced to express the relationships between the matric suctions of two soil samples. The parameter β is a function of the initial void ratio, matric suction or volumetric water content. The function can take different forms, resulting in different predictive models. The optimal predictive models of β are determined for coarse-grained and fine-grained soils using the Bayesian method. The optimal models of β are validated by comparing the estimated matric suction and measured data. The comparisons show that the proposed method produces more accurate SWRCs than do other models for both coarse-grained and fine-grained soils. Furthermore, the influence of the model parameters of β on the predicted matric suction and SWRC is evaluated using Latin Hypercube sampling. An uncertainty analysis shows that the reliability of the predicted SWRC decreases with decreasing water content in fine-grained soils, and the initial void ratio has no apparent influence on the reliability of the predicted SWRCs in coarse-grained and fine-grained soils.

  4. Micron-scale Reactive Atomistic Simulation of Void Collapse and Hotspot Growth in PETN

    Science.gov (United States)

    Thompson, Aidan; Shan, Tzu-Ray; Wixom, Ryan

    2015-06-01

    Material defects and other heterogeneities such as dislocations, micro-porosity, and grain boundaries play key roles in the shock-induced initiation of detonation in energetic materials. We performed non-equilibrium molecular dynamics simulations to explore the effect of nanoscale voids on hotspot growth and initiation in micron-scale pentaerythritol tetranitrate (PETN) crystals under weak shock loading (Up = 1.25 km/s; Us = 4.5 km/s). We used the ReaxFF potential implemented in LAMMPS. We built a pseudo-2D PETN crystal with dimensions 0.3 μm × 0.22 μm × 1.3 nm containing a 20 nm cylindrical void. Once the initial shockwave traversed the entire sample, the shock-front absorbing boundary condition was applied, allowing the simulation to continue beyond 1 nanosecond. Results show an exponentially increasing hotspot growth rate. The hotspot morphology is initially symmetric about the void axis, but strong asymmetry develops at later times, due to strong coupling between exothermic chemistry, temperature, and divergent secondary shockwaves emanating from the collapsing void. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. DOE National Nuclear Security Administration under Contract DE-AC04-94AL85000.

  5. Large scale structure simulations of inhomogeneous Lemaître-Tolman-Bondi void models

    Science.gov (United States)

    Alonso, David; García-Bellido, Juan; Haugbølle, Troels; Vicente, Julián

    2010-12-01

    We perform numerical simulations of large scale structure evolution in an inhomogeneous Lemaître-Tolman-Bondi (LTB) model of the Universe. We follow the gravitational collapse of a large underdense region (a void) in an otherwise flat matter-dominated Einstein-de Sitter model. We observe how the (background) density contrast at the center of the void grows to be of order one, and show that the density and velocity profiles follow the exact nonlinear LTB solution to the full Einstein equations for all but the most extreme voids. This result seems to contradict previous claims that fully relativistic codes are needed to properly handle the nonlinear evolution of large scale structures, and that local Newtonian dynamics with an explicit expansion term is not adequate. We also find that the (local) matter density contrast grows with the scale factor in a way analogous to that of an open universe with a value of the matter density ΩM(r) corresponding to the appropriate location within the void.

  6. Why a steady state void size distribution in irradiated UO2? A modeling approach

    Science.gov (United States)

    Maillard, S.; Martin, G.; Sabathier, C.

    2016-05-01

    In UO2 pellets irradiated in standard water reactor, Xe nano-bubbles nucleate, grow, coarsen and finally reach a quasi steady state size distribution: transmission electron microscope (TEM) observations typically report a concentration around 10-4 nm-3 and a radius around 0.5 nm. This phenomenon is often considered as a consequence of radiation enhanced diffusion, precipitation of gas atoms and ballistic mixing. However, in UO2 thin foils irradiated with energetic ions at room temperature, a nano-void population whose size distribution reaches a similar steady state can be observed, although quasi no foreign atoms are implanted nor significant cation vacancy diffusion expected in conditions. Atomistic simulations performed at low temperature only address the first stage of the process, supporting the assumption of void heterogeneous nucleation: 25 keV sub-cascades directly produce defect aggregates (loops and voids) even in the absence of gas atoms and thermal diffusion. In this work a semi-empirical stochastic model is proposed to enlarge the time scale covered by simulation up to damage levels where every point in the material undergoes the superposition of a large number of sub-cascade impacts. To account for the accumulation of these impacts, simple rules inferred from the atomistic simulation results are used. The model satisfactorily reproduces the TEM observations of nano-voids size and concentration, which paves the way for the introduction of a more realistic damage term in rate theory models.

  7. Generalized Rate Theory for Void and Bubble Swelling and its Application to Plutonium Metal Alloys

    Energy Technology Data Exchange (ETDEWEB)

    Allen, P. G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Wolfer, W. G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-10-16

    In the classical rate theory for void swelling, vacancies and self-interstitials are produced by radiation in equal numbers, and in addition, thermal vacancies are also generated at the sinks, primarily at edge dislocations, at voids, and at grain boundaries. In contrast, due to the high formation energy of self-interstitials for normal metals and alloys, their thermal generation is negligible, as pointed out by Bullough and Perrin [1]. However, recent DFT calculations of the formation energy of self-interstitial atoms in bcc metals [2,3] have revealed that the sum of formation and migration energies for self-interstitials atoms (SIA) is of the same order of magnitude as for vacancies. This is illustrated in Fig. 1 that shows the ratio of the activation energies for thermal generation of SIA and vacancies. For fcc metals, this ratio is around three, but for bcc metals it is around 1.5. Reviewing theoretical predictions of point defect properties in δ-Pu [4], this ratio could possibly be less than one. As a result, thermal generation of SIA in bcc metals and in plutonium must be taken into considerations when modeling the growth of voids and of helium bubbles, and the classical rate theory (CRT) for void and bubble swelling must be extended to a generalized rate theory (GRT).

  8. Muscle dysfunction in cancer patients

    DEFF Research Database (Denmark)

    Christensen, Jesper Frank; Jones, L W; Andersen, J L

    2014-01-01

    implications of muscle dysfunction in cancer patients. The efficacy of exercise training to prevent and/or mitigate cancer-related muscle dysfunction is also discussed. DESIGN: We identified 194 studies examining muscular outcomes in cancer patients by searching PubMed and EMBASE databases. RESULTS: Muscle...... dysfunction is evident across all stages of the cancer trajectory. The causes of cancer-related muscle dysfunction are complex, but may involve a wide range of tumor-, therapy- and/or lifestyle-related factors, depending on the clinical setting of the individual patient. The main importance of muscle...... dysfunction in cancer patients lies in the correlation to vital clinical end points such as cancer-specific and all-cause mortality, therapy complications and quality of life (QoL). Such associations strongly emphasize the need for effective therapeutic countermeasures to be developed and implemented...

  9. Microscopic air void analysis of hardened Portland cement concrete by the isolated shadow technique

    Science.gov (United States)

    Harris, Basil Mark

    The Isolated Shadow Technique is an image processing and analysis procedure for identifying and characterizing surface voids dispersed on an otherwise flat plane of heterogeneous solids. The objective of the Isolated Shadow Technique is to capture, process, and analyze images of a flat surface in which all of the features, save the boundary outlines of any surface voids, are eliminated. In short, the technique utilizes a series of digital images of the subject planar surface; where each image of the series is subjected to a unique lighting condition. By positioning the lights such that the shadows cast into the craters vary between images, these variations can be sequestered and the edges of the voids can subsequently be reconstructed from the isolated shadows. The primary purpose of this work was the development of the Isolated Shadow Technique for the particular application of quantitatively describing the microscopic voids in hardened Portland cement concrete. The Isolated Shadow System was developed for this application of the technique. The hardware and software of the system are described and the function is demonstrated. The system was found to have an average accuracy of 2.7% with a maximum deviation of 5.0% when compared to physical measurements. The results of polished sections of concrete specimens characterized by the Isolated Shadow System are compared to the results obtained with the commonly used standard methods (ASTM C 457; A and B). The coefficients of variation of parameters calculated to describe the air-void system (according to the ASTM C 457 formulations) are shown to be in the neighborhood of one percent when the observed test area includes at least 7,830 mmsp2 of polished concrete (with paste contents ranging from approximately 28% to 32%). The sensitivity of the air-void system parameters (as computed by the system) to changes in magnification and mosaic size are evaluated. A critical analysis of the underlying assumptions of the ASTM C

  10. Uroflowmetry in neurologically normal children with voiding disorders

    DEFF Research Database (Denmark)

    Jensen, K M; Nielsen, K.K.; Kristensen, E S

    1985-01-01

    of neurological deficits underwent a complete diagnostic program including intravenous urography, voiding cystography and cystoscopy as well as spontaneous uroflowmetry, cystometry-emg and pressure-flow-emg study. The incidence of dyssynergia was 22%. However, neither the flow curve pattern nor single flow...... variables were able to identify children with dyssynergia. Consequently uroflowmetry seems inefficient in the screening for dyssynergia in neurological normal children with voiding disorders in the absence of anatomical bladder outlet obstruction....

  11. The Effect of Nearby Voids on Galaxy Number Counts

    CERN Document Server

    Bucklein, Brian K; Hintz, Eric G

    2016-01-01

    The size, shape and degree of emptiness of void interiors sheds light on the details of galaxy formation. A particularly interesting question is whether void interiors are completely empty or contain a dwarf population. However the nearby voids that are most conducive for dwarf searches have large angular diameters, on the order of a steradian, making it difficult to redshift-map a statistically significant portion of their volume to the magnitude limit of dwarf galaxies. As part of addressing this problem, we investigate here the usefulness of number counts in establishing the best locations to search inside nearby (d < 300 Mpc) galaxy voids, utilizing Wolf plots of log(n < m) vs. m as the basic diagnostic. To illustrate expected signatures, we consider the signature of three void profiles, "cut out", "built up", and "universal profile" carved into Monte-Carlo Schechter function models. We then investigate the signatures of voids in the Millennium Run dark matter simulation and the Sloan Digital Sky Su...

  12. Stokes-Brinkman formulation for prediction of void formation in dual-scale fibrous reinforcements: a BEM/DR-BEM simulation

    Science.gov (United States)

    Patiño, Iván David; Power, Henry; Nieto-Londoño, César; Flórez, Whady Felipe

    2017-02-01

    A numerical study of voids formation in dual-scale fibrous reinforcements is presented. Flow fields in channels (Stokes) and tows (Brinkman) are solved via direct Boundary Element Method and Dual Reciprocity Boundary Element Method, respectively. The present approach uses only boundary discretization and Dual Reciprocity domain interpolation, which is advantageous in this type of moving boundary problems and leads to an accurate representation of the moving interfaces. A problem admitting analytical solution, previously solved by domain-meshing techniques, is used to assess the accuracy of the present approach, obtaining satisfactory results. Fillings of Representative Unitary Cells at constant pressure are considered to analyze the influence of capillary ratio, jump stress coefficient and two formulations (Stokes-Brinkman and Stokes-Darcy) on the filling process, void formation and void characterization. Filling times, fluid front shapes, void size and shape, time and space evolution of the saturation, are influenced by these parameters, but voids location is not.

  13. Effects of voids on delamination behavior under static and fatigue mode I and mode II

    Science.gov (United States)

    Abdelal, Nisrin Rizek

    Composite materials have become materials of choice for wind turbine blade manufacturing due to their high specific stiffness, strength and fatigue life. Glass fiber composites are used extensively in light-weight structural components for wind turbines, aircrafts, marine craft and high performance automobile because glass fiber is inexpensive and usually provides high strength to weight ratio and good in-plane mechanical properties. The high cycle fatigue resistance of composite materials used in wind turbine blades has been recognized as a major uncertainty in predicting the reliability of wind turbines over their design lifetime. Blades are expected to experience 108 to 109 fatigue cycles over a 20 to 30 year lifetime. Delamination or interlaminar failure is a serious failure mode observed in composite structures. Even partial delamination will lead to a loss of local stiffness, which can preclude buckling failure. Manufacturing process defects such as voids and fiber waviness degrade the fatigue life and delamination resistance of the blade's composite. This research describes the effect of voids on static and fatigue interlaminar fracture behavior under mode I and mode II loading of wind turbine glass fiber composites. Samples with different void volume fractions in the 0.5%-7% range were successfully obtained by varying the vacuum in the hand layup vacuum bagging manufacturing process. Void content was characterized using four different methods; ultrasonic scanning, epoxy burn off, serial sectioning and X-Ray computed tomography. The effect of voids on both mode I and mode II interlaminar fracture toughness under static and fatigue loading was investigated. Finally, fractographic analysis (using optical and scanning electron microscopy) was conducted. The results showed that voids leads to slight reduction in static modes I and II interlaminar fracture toughness. In addition, voids lead to a decrease in modes I and II maximum cyclic strain energy release

  14. Obesity-initiated metabolic syndrome promotes urinary voiding dysfunction in a mouse model.

    Science.gov (United States)

    He, Qiqi; Babcook, Melissa A; Shukla, Sanjeev; Shankar, Eswar; Wang, Zhiping; Liu, Guiming; Erokwu, Bernadette O; Flask, Chris A; Lu, Lan; Daneshgari, Firouz; MacLennan, Gregory T; Gupta, Sanjay

    2016-08-01

    Accumulating evidences suggests that obesity and metabolic syndrome (MetS) contribute towards lower urinary tract symptoms (LUTS) through alterations in the phenotype of bladder and prostate gland. Clinical studies indicate a link between MetS and LUTS. Nevertheless, there is lack of suitable animal model(s) which could illustrate an association linking obesity to LUTS. We examined the lower urinary tract function in an obesity-initiated MetS mouse model. Male C57BL/6N wild-type and obese B6.V-Lepob/J maintained on regular diet for 28 weeks were subjected to the assessment of body weight (BW), body length (BL), waist circumference (WC), body mass index (BMI), blood glucose (BG), plasma insulin (INS), plasma leptin (LEP), total cholesterol (CHO), free fatty acid (FFA), and measurement of urinary functions. Whole animal peritoneal and subcutaneous adipose tissue measurements as well as prostate and bladder volumes were analyzed by MRI followed by histological evaluation. These parameters were used to draw correlations between MetS and LUTS. Obesity parameters such as BW, WC, and BMI were significantly higher in B6.V-Lepob/J mice compared to C57BL/6N mice (P obesity and MetS. Validation of an in vivo model may lead to understand the underlying pathophysiological mechanisms of obesity-related LUTS in humans. Prostate 76:964-976, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  15. Squamous Cell Carcinoma of the Bladder Mimicking Interstitial Cystitis and Voiding Dysfunction

    Directory of Open Access Journals (Sweden)

    Colton Prudnick

    2013-01-01

    Full Text Available Squamous cell carcinoma (SCC of the bladder is a relatively uncommon cause of bladder cancer accounting for <5% of bladder tumors in the western countries. SCC has a slight male predominance and tends to occur in the seventh decade of life. The main presenting symptom of SCC is hematuria, and development of this tumor in the western world is associated most closely with chronic indwelling catheters and spinal cord injuries. A 39-year-old Caucasian female presented with bladder and lower abdominal pain, urinary frequency, and nocturia which was originally believed to be interstitial cystitis (IC but was later diagnosed as SCC of the bladder. Presentation of SCC without hematuria is an uncommon presentation, but the absence of this symptom should not lead a practitioner to exclude the diagnosis of SCC. This case is being reported in an attempt to explain the delay and difficulty of diagnosis. Background on the risk factors for SCC of the bladder and the typical presenting symptoms of bladder SCC and IC are also reviewed.

  16. Rosa damascena oil improves SSRI-induced sexual dysfunction in male patients suffering from major depressive disorders: results from a double-blind, randomized, and placebo-controlled clinical trial

    Directory of Open Access Journals (Sweden)

    Farnia V

    2015-03-01

    Full Text Available Vahid Farnia,1 Mehdi Shirzadifar,2 Jalal Shakeri,1 Mansour Rezaei,3 Hafez Bajoghli,4,5 Edith Holsboer-Trachsler,6 Serge Brand6,7 1Substance Abuse Prevention Research Center, Psychiatry Department, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Student Research Center, Psychiatry Department, Kermanshah University of Medical Sciences, Kermanshah, Iran; 3Department of Statistics and Epidemiology, Kermanshah University of Medical Sciences, Kermanshah, Iran; 4Iranian National Center for Addiction Studies, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran; 5ASEAN Institute for Health Development, Mahidol University, Nakhon Pathom, Thailand; 6Psychiatric Clinics of the Center for Affective, Stress and Sleep Disorders, Psychiatric Hospital of the University of Basel, Basel, Switzerland; 7Sport Science Section, Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland Background: A substantial disadvantage of psychopharmacological treatment of major depressive disorder (MDD with selective serotonin-reuptake inhibitors (SSRIs is the impact on sexual dysfunction. The aim of the present study was to investigate whether the oil of Rosa damascena can have a positive influence on SSRI-induced sexual dysfunction (SSRI-I SD of male patients who are suffering from MDD and are being treated with SSRIs.Method: In a double-blind, randomized, and placebo-controlled clinical trial, a total of 60 male patients treated with an SSRI and suffering from MDD (mean age =32 years and SSRI-I SD were randomly assigned to take either verum (R. damascena oil or a placebo. Patients completed self-ratings of depression and sexual function at baseline, at 4 weeks later, and at the end of the study, 8 weeks after it started.Results: Over time, sexual dysfunction improved more in the verum group than in the control group. Improvements were observed in the verum group from week 4 to week

  17. Effects of void size and gas content on electrical breakdown in lightweight, mechanically compliant, void-filled dielectrics

    Science.gov (United States)

    Anderson, R. A.; Lagasse, R. R.; Russick, E. M.; Schroeder, J. L.

    2002-03-01

    Dielectric potting materials (encapsulants) are used to prevent air breakdown in high-voltage electrical devices. We report breakdown strengths in void-filled encapsulants, stressed with unipolar voltage pulses of the order of 10 μs duration. High strengths, on the order of 100 kV mm-1, are measured under these test conditions. The materials studied include low-density open celled gel-derived foams with cell sizes of 4 μm or less, closed celled CO2-blown polystyrene and urethane foams, and epoxies containing 48 vol % of hollow glass microballoon (GMB) fillers. These last specimens varied the void gas (N2 or SO2) and also the void diameters (tens to hundreds of μm). Our measurements are thought to be directly sensitive to the rate of field-induced ionization events in the void gas; however, the breakdown strengths of the materials tested appeared to vary in direct proportion with the conventional Paschen-law gas-discharge inception threshold, the electric stress at which gas-ionization avalanches become possible. The GMB-epoxy specimens displayed this type of dependence of breakdown strength on the void-gas density and void size, but the measurements were an order of magnitude above the conventional predictions. Small-celled foams also showed increased breakdown strengths with decreased cell size, although their irregular void geometry prevented a direct comparison with the more uniformly structured microballoon-filled encapsulants. The experimental observations are consistent with a breakdown mechanism in which the discharge of a few voids can launch a full breakdown in the composite material.

  18. DETECTION OF MOLECULAR GAS IN VOID GALAXIES: IMPLICATIONS FOR STAR FORMATION IN ISOLATED ENVIRONMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Das, M.; Honey, M. [Indian Institute of Astrophysics, Bangalore (India); Saito, T. [Department of Astronomy, Graduate school of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 133-0033 (Japan); Iono, D. [Chile Observatory, NAOJ (Japan); Ramya, S., E-mail: mousumi@iiap.res.in [Shanghai Astronomical Observatory, Shanghai (China)

    2015-12-10

    We present the detection of molecular gas from galaxies located in nearby voids using the CO(1–0) line emission as a tracer. The observations were performed using the 45 m single dish radio telescope of the Nobeyama Radio Observatory. Void galaxies lie in the most underdense parts of our universe and a significant fraction of them are gas rich, late-type spiral galaxies. Although isolated, they have ongoing star formation but appear to be slowly evolving compared to galaxies in denser environments. Not much is known about their star formation properties or cold gas content. In this study, we searched for molecular gas in five void galaxies. The galaxies were selected based on their relatively high IRAS fluxes or Hα line luminosities, both of which signify ongoing star formation. All five galaxies appear to be isolated and two lie within the Bootes void. We detected CO(1–0) emission from four of the five galaxies in our sample and their molecular gas masses lie between 10{sup 8} and 10{sup 9} M{sub ⊙}. We conducted follow-up Hα imaging observations of three detected galaxies using the Himalayan Chandra Telescope and determined their star formation rates (SFRs) from their Hα fluxes. The SFR varies from 0.2 to 1 M{sub ⊙} yr{sup −1}; which is similar to that observed in local galaxies. Our study indicates that although void galaxies reside in underdense regions, their disks contain molecular gas and have SFRs similar to galaxies in denser environments. We discuss the implications of our results.

  19. Void fraction in horizontal bulk flow boiling at high flow qualities

    Energy Technology Data Exchange (ETDEWEB)

    Collado, Fancisco J.; Monne, Carlos [Dpto. de Ingenieria Mecanica, Universidad de Zaragoza-CPS, Maria de Luna 3, 50018-Zaragoza (Spain); Pascau, Antonio [Dpto. de Ciencia de los Materiales y Fluidos, Universidad de Zaragoza-CPS, Maria de Luna 3, 50018-Zaragoza (Spain)

    2008-04-15

    In this work, a new thermodynamic prediction of the vapor void fraction in bulk flow boiling, which is the core process of many energy conversion systems, is analyzed. The current heat balance is based on the flow quality, which is closely related to the measured void fraction, although some correlation for the vapor-liquid velocity ratio is needed. So here, it is suggested to work with the 'static' or thermodynamic quality, which is directly connected to the void fraction through the densities of the phases. Thus, the relation between heat and the mixture enthalpy (here based on the thermodynamic quality instead of the flow one) should be analyzed in depth. The careful void fraction data taken by Thom during the 'Cambridge project' for horizontal saturated flow boiling with high flow qualities ({<=}0.8) have been used for this analysis. As main results, first, we have found that the applied heat and the increment of the proposed thermodynamic enthalpy mixture throughout the heated duct do not agree, and for closure, a parameter is needed. Second, it has been checked that this parameter is practically equal to the classic velocity ratio or 'slip' ratio, suggesting that it should be included in a true thermodynamic heat balance. Furthermore, it has been clearly possible to improve the 'Cambridge project' correlations for the 'slip' ratio, here based on inlet pressure and water velocity, and heat flux. The calculated void fractions compare quite well with the measured ones. Finally, the equivalence of the suggested new heat balance with the current one through the 'slip' ratio is addressed. Highlighted is the same new energetic relation for saturated flow boiling that has been recently confirmed by the authors for Knights data, also taken during the 'Cambridge project', which include not only horizontal but also vertical upwards flows with moderate outlet flow quality ({<=}0.2). (author)

  20. Tadalafil once daily and extracorporeal shock wave therapy in the management of patients with Peyronie's disease and erectile dysfunction: results from a prospective randomized trial.

    Science.gov (United States)

    Palmieri, A; Imbimbo, C; Creta, M; Verze, P; Fusco, F; Mirone, V

    2012-04-01

    Extracorporeal shock wave therapy improves erectile function in patients with Peyronie's disease. However, erectile dysfunction still persists in many cases. We aimed to investigate the effects of extracorporeal shock wave therapy plus tadalafil 5 mg once daily in the management of patients with Peyronie's disease and erectile dysfunction not previously treated. One hundred patients were enrolled in a prospective, randomized, controlled study. Patients were randomly allocated to receive either extracorporeal shock wave therapy alone for 4 weeks (n = 50) or extracorporeal shock wave therapy plus tadalafil 5 mg once daily for 4 weeks (n = 50). Main outcome measures were: erectile function (evaluated through the shortened version of the International Index of Erectile Function), pain during erection (evaluated through a Visual Analog Scale), plaque size, penile curvature and quality of life (evaluated through an internal questionnaire). Follow-up evaluations were performed after 12 and 24 weeks. In both groups, at 12 weeks follow-up, mean Visual Analog Scale score, mean International Index of Erectile Function score and mean quality of life score ameliorated significantly while mean plaque size and mean curvature degree were unchanged. Intergroup analysis revealed a significantly higher mean International Index of Erectile Function score and quality of life score in patients receiving the combination. After 24 weeks, intergroup analysis revealed a significantly higher mean International Index of Erectile Function score and mean quality of life score in patients that received extracorporeal shock wave therapy plus tadalafil. In conclusion extracorporeal shock wave therapy plus tadalafil 5 mg once daily may represent a valid conservative strategy for the management of patients with Peyronie's disease and erectile dysfunction.

  1. Isolation and control of voids and void-hillocks during molecular beam epitaxial growth of HgCdTe

    Science.gov (United States)

    Chandra, D.; Aqariden, F.; Frazier, J.; Gutzler, S.; Orent, T.; Shih, H. D.

    2000-06-01

    Formation of small voids and defect complexes involving small voids during the molecular beam epitaxial growth of mercury cadmium telluride on cadmium zinc telluride was investigated. Some of these defects were demonstrated to form away from the substrate-epi interface. Other defects were demonstrated to close before reaching the top surface without leaving any perturbations on the surface, thus remaining completely hidden. The voids, which formed away from the substrate-epifilm fixed interface, nucleated on defects introduced into the film already grown, leading to the formation of defect complexes, unlike the voids which nucleated at the substrate-epifilm fixed interface. These defect complexes are decorated with high density dislocation nests. The voids which closed before reaching the film surface usually also nucleated slightly away from the film-substrate interface, continued to replicate for a while as the growth progressed, but then relatively rapidly closed off at a significant depth from the film surface. These voids also appeared to form defect complexes with other kinds of defects. Correlations between these materials defects and performance of individual vertically integrated photodiode (VIP) devices were demonstrated, where the relative location of these defects with respect to the junction boundary appears to be particularly important. Elimination or reduction of fluctuations in relative flux magnitudes or substrate temperature, more likely during multi-composition layer growth, yielded films with significantly lower defect concentrations.

  2. Optimal bladder diary duration for patients with suprapontine neurogenic lower urinary tract dysfunction

    Directory of Open Access Journals (Sweden)

    Charalampos Konstantinidis

    Full Text Available ABSTRACT Purpose: To identify the minimum bladder diary's length required to furnish reliable documentation of LUTS in a specific cohort of patients suffering from neurogenic urinary dysfunction secondary to suprapontine pathology. Materials and Methods: From January 2008 to January 2014, patients suffering from suprapontine pathology and LUTS were requested to prospectively complete a bladder diary form for 7 consecutive days. Micturitions per day, excreta per micturition, urgency and incontinence episodes and voided volume per day were evaluated from the completed diaries. We compared the averaged records of consecutive days (2-6 days to the total 7 days records for each patient's diary, seeking the minimum diary's length that could provide records comparable to the 7 days average, the reference point in terms of reliability. Results: From 285 subjects, 94 male and 69 female patients enrolled in the study. The records of day 1 were significantly different from the average of the 7 days records in every parameter, showing relatively small correlation and providing insufficient documentation. Correlations gradually increased along the increase in diary's duration. According to our results a 3-day duration bladder diary is efficient and can provide results comparable to a 7 day length for four of our evaluated parameters. Regarding incontinence episodes, 3 days seems inadequate to furnish comparable results, showing a borderline difference. Conclusions: A 3-day diary can be used, as its reliability is efficient regarding number of micturition per day, excreta per micturition, episodes of urgency and voided volume per day.

  3. Size-effects at a crack-tip interacting with a number of voids

    DEFF Research Database (Denmark)

    Tvergaard, Viggo; Niordson, Christian Frithiof

    2008-01-01

    of the characteristic material length relative to the initial void radius. For a case showing the multiple void mechanism, it is found that the effect of the material length can change the behaviour towards the void by void mechanism. A material model with three characteristic length scales is compared with a one...

  4. A study of process induced voids in resistance welding of thermoplastic composites

    NARCIS (Netherlands)

    Shi, H.; Fernandez Villegas, I.; Bersee, H.E.N.

    2015-01-01

    Void formation in resistance welding of woven fabric reinforced thermoplastic composites was investigated. Void contents were measured using optical microscopy and digital image process. Un-even void distributions were observed in the joints, and more voids were found in the middle of the joints tha

  5. THE INSTABILITY OF THE DIFFUSION-CONTROLLED GRAIN-BOUNDARY VOID IN STRESSED SOLID

    Institute of Scientific and Technical Information of China (English)

    王华; 李中华

    2003-01-01

    As atoms migrate along a void surface and grain-boundary, driven by various thermodynamic forces, the grain-boundary void changes its shape and volume. When the void changes its configuration, the free energy of the system also changes. In this article, the free energy is calculated for an evolving grain-boundary void filled with gas in a stressed solid. Then the instability conditions and the equilibrium shape of the void are determined as a function of the grain-boundary and surface energies, the void volume, the externally applied stresses, as well as the internal pressure built up by the gas filled in the void.

  6. Prevalence of urinary tract infection and vesicoureteral reflux in children with lower urinary tract dysfunction.

    Science.gov (United States)

    Van Batavia, Jason P; Ahn, Jennifer J; Fast, Angela M; Combs, Andrew J; Glassberg, Kenneth I

    2013-10-01

    Lower urinary tract dysfunction is a common pediatric urological problem that is often associated with urinary tract infection. We determined the prevalence of a urinary tract infection history in children with lower urinary tract dysfunction and its association, if any, with gender, bowel dysfunction, vesicoureteral reflux and specific lower urinary tract conditions. We retrospectively reviewed the charts of children diagnosed with and treated for lower urinary tract dysfunction, noting a history of urinary tract infection with or without fever, gender, bowel dysfunction and vesicoureteral reflux in association with specific lower urinary tract conditions. Of the 257 boys and 366 girls with a mean age of 9.1 years 207 (33%) had a urinary tract infection history, including 88 with at least 1 febrile infection. A total of 64 patients underwent voiding cystourethrogram/videourodynamics, which revealed reflux in 44 (69%). In 119 of the 207 patients all infections were afebrile and 18 underwent voiding cystourethrogram/videourodynamics, which revealed reflux in 5 (28%). A urinary tract infection history was noted in 53% of girls but only 5% of boys (p infection history than patients with idiopathic detrusor overactivity disorder or primary bladder neck dysfunction (each p urinary tract dysfunction have a much higher urinary tract infection incidence than males. This association was most often noted for lower urinary tract conditions in which urinary stasis occurs, including detrusor underutilization disorder and dysfunctional voiding. Reflux was found in most girls with a history of febrile infections. Since reflux was identified in more than a quarter of girls with only afebrile infections who were evaluated for reflux, it may be reasonable to perform voiding cystourethrogram or videourodynamics in some of them to identify reflux. Copyright © 2013 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  7. Dysfunctional Uterine Bleeding

    OpenAIRE

    1987-01-01

    Dysfunctional uterine bleeding (DUB) is defined as abnormal uterine bleeding that results from an ovarian endocrinopathy. It may be associated with ovulatory and anovulatory cycles. The diagnosis of DUB depends on a thorough history and physical examination to exclude organic disorders. In older women, endometrial biopsy should be done before starting therapy. The treatment depends on an understanding of the menstrual cycle. In less urgent cases, anovulatory cycles are managed using progester...

  8. Towards a better understanding of dielectric barrier discharges in ferroelectrets: Paschen breakdown fields in micrometer sized voids

    Science.gov (United States)

    Harris, Scott; Mellinger, Axel

    2014-04-01

    Charged cellular polypropylene foams (i.e., ferro- or piezoelectrets) demonstrate high piezoelectric activity upon being electrically charged. When an external electric field is applied, dielectric barrier discharges (DBDs) occur, resulting in a separation of charges which are subsequently deposited on dielectric surfaces of internal micrometer sized voids. This deposited space charge is responsible for the piezoelectric activity of the material. Previous studies have indicated charging fields larger than predicted by Townsend's model of Paschen breakdown applied to a multilayered electromechanical model; a discrepancy which prompted the present study. The actual breakdown fields for micrometer sized voids were determined by constructing single cell voids using polypropylene spacers with heights ranging from 8 to 75 μm, "sandwiched" between two polypropylene dielectric barriers and glass slides with semi-transparent electrodes. Subsequently, a bipolar triangular charging waveform with a peak voltage of 6 kV was applied to the samples. The breakdown fields were determined by monitoring the emission of light due to the onset of DBDs using an electron multiplying CCD camera. The breakdown fields at absolute pressures from 101 to 251 kPa were found to be in good agreement with the standard Paschen curves. Additionally, the magnitude of the light emission was found to scale linearly with the amount of gas, i.e., the height of the voids. Emissions were homogeneous over the observed regions of the voids for voids with heights of 25 μm or less and increasingly inhomogeneous for void heights greater than 40 μm at high electric fields.

  9. Autonomous robot for detecting subsurface voids and tunnels using microgravity

    Science.gov (United States)

    Wilson, Stacy S.; Crawford, Nicholas C.; Croft, Leigh Ann; Howard, Michael; Miller, Stephen; Rippy, Thomas

    2006-05-01

    Tunnels have been used to evade security of defensive positions both during times of war and peace for hundreds of years. Tunnels are presently being built under the Mexican Border by drug smugglers and possibly terrorists. Several have been discovered at the border crossing at Nogales near Tucson, Arizona, along with others at other border towns. During this war on terror, tunnels under the Mexican Border pose a significant threat for the security of the United States. It is also possible that terrorists will attempt to tunnel under strategic buildings and possibly discharge explosives. The Center for Cave and Karst Study (CCKS) at Western Kentucky University has a long and successful history of determining the location of caves and subsurface voids using microgravity technology. Currently, the CCKS is developing a remotely controlled robot which will be used to locate voids underground. The robot will be a remotely controlled vehicle that will use microgravity and GPS to accurately detect and measure voids below the surface. It is hoped that this robot will also be used in military applications to locate other types of voids underground such as tunnels and bunkers. It is anticipated that the robot will be able to function up to a mile from the operator. This paper will describe the construction of the robot and the use of microgravity technology to locate subsurface voids with the robot.

  10. 3D Property Modeling of Void Ratio by Cokriging

    Institute of Scientific and Technical Information of China (English)

    Yao Lingqing; Pan Mao; Cheng Qiuming

    2008-01-01

    Void ratio measures compactness of ground soil in geotechnical engineering. When samples are collected in certain area for mapping void ratios, other relevant types of properties such as water content may be also analyzed. To map the spatial distribution of void ratio in the area based on these types of point, observation data interpolation is often needed. Owing to the variance of sampling density along the horizontal and vertical directions, special consideration is required to handle anisotropy of estimator. 3D property modeling aims at predicting the overall distribution of property values from limited samples, and geostatistical method can he employed naturally here because they help to minimize the mean square error of estimation. To construct 3D property model of void ratio, cokriging was used considering its mutual correlation with water content, which is another important soil parameter. Moreover, K-D tree was adopted to organize the samples to accelerate neighbor query in 3D space during the above modeling process. At last, spatial configuration of void ratio distribution in an engineering body was modeled through 3D visualization, which provides important information for civil engineering purpose.

  11. Only the Lonely: H I Imaging of Void Galaxies

    CERN Document Server

    Kreckel, K; Aragón-Calvo, M A; van Gorkom, J H; van de Weygaert, R; van der Hulst, J M; Kovač, K; Yip, C -W; Peebles, P J E

    2010-01-01

    Void galaxies, residing within the deepest underdensities of the Cosmic Web, present an ideal population for the study of galaxy formation and evolution in an environment undisturbed by the complex processes modifying galaxies in clusters and groups, as well as provide an observational test for theories of cosmological structure formation. We have completed a pilot survey for the HI imaging aspects of a new Void Galaxy Survey (VGS), imaging 15 void galaxies in HI in local (d < 100 Mpc) voids. HI masses range from 3.5 x 10^8 to 3.8 x 10^9 M_sun, with one nondetection with an upper limit of 2.1 x 10^8 M_sun. Our galaxies were selected using a structural and geometric technique to produce a sample that is purely environmentally selected and uniformly represents the void galaxy population. In addition, we use a powerful new backend of the Westerbork Synthesis Radio Telescope that allows us to probe a large volume around each targeted galaxy, simultaneously providing an environmentally constrained sample of for...

  12. Constraints on Cosmology and Gravity from the Dynamics of Voids

    Science.gov (United States)

    Hamaus, Nico; Pisani, Alice; Sutter, P. M.; Lavaux, Guilhem; Escoffier, Stéphanie; Wandelt, Benjamin D.; Weller, Jochen

    2016-08-01

    The Universe is mostly composed of large and relatively empty domains known as cosmic voids, whereas its matter content is predominantly distributed along their boundaries. The remaining material inside them, either dark or luminous matter, is attracted to these boundaries and causes voids to expand faster and to grow emptier over time. Using the distribution of galaxies centered on voids identified in the Sloan Digital Sky Survey and adopting minimal assumptions on the statistical motion of these galaxies, we constrain the average matter content Ωm=0.281 ±0.031 in the Universe today, as well as the linear growth rate of structure f /b =0.417 ±0.089 at median redshift z ¯=0.57 , where b is the galaxy bias (68% C.L.). These values originate from a percent-level measurement of the anisotropic distortion in the void-galaxy cross-correlation function, ɛ =1.003 ±0.012 , and are robust to consistency tests with bootstraps of the data and simulated mock catalogs within an additional systematic uncertainty of half that size. They surpass (and are complementary to) existing constraints by unlocking cosmological information on smaller scales through an accurate model of nonlinear clustering and dynamics in void environments. As such, our analysis furnishes a powerful probe of deviations from Einstein's general relativity in the low-density regime which has largely remained untested so far. We find no evidence for such deviations in the data at hand.

  13. Magnetic pattern at supergranulation scale: the Void Size Distribution

    CERN Document Server

    Berrilli, Francesco; Del Moro, Dario

    2014-01-01

    The large-scale magnetic pattern of the quiet sun is dominated by the magnetic network. This network, created by photospheric magnetic fields swept into convective downflows, delineates the boundaries of large scale cells of overturning plasma and exhibits voids in magnetic organization. Such voids include internetwork fields, a mixed-polarity sparse field that populate the inner part of network cells. To single out voids and to quantify their intrinsic pattern a fast circle packing based algorithm is applied to 511 SOHO/MDI high resolution magnetograms acquired during the outstanding solar activity minimum between 23 and 24 cycles. The computed Void Distribution Function shows a quasi-exponential decay behavior in the range 10-60 Mm. The lack of distinct flow scales in such a range corroborates the hypothesis of multi-scale motion flows at the solar surface. In addition to the quasi-exponential decay we have found that the voids reveal departure from a simple exponential decay around 35 Mm.

  14. Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver Dysfunction

    Science.gov (United States)

    Miura, Yasuo; Matsui, Yusuke; Kaneko, Hitomi; Watanabe, Mitsumasa; Tsudo, Mitsuru

    2010-01-01

    Iron chelation therapy (ICT) has been applied for the patients with iron overload-associated liver dysfunction since it is one of the causes of death in patients with intractable hematological diseases requiring multiple red blood cell transfusions. Recently, deferasirox (DSX), a novel, once-daily oral iron chelator, was demonstrated to have similar efficacy to the conventional continuous infusion of deferoxamine on a decrease in serum ferritin (SF) level in heavily transfused patients. We show three cases of transfusion-mediated iron-overloaded patients with an elevated serum alanine aminotransaminase (ALT). All three patients who received the ICT with DSX showed a decrease in ALT level in association with a decrease in SF level. It is suggested that DSX therapy could be considered to expect the improvement of liver damage for iron-overloaded patients with an abnormal ALT level. PMID:20592762

  15. Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver Dysfunction

    Directory of Open Access Journals (Sweden)

    Yasuo Miura

    2010-01-01

    Full Text Available Iron chelation therapy (ICT has been applied for the patients with iron overload-associated liver dysfunction since it is one of the causes of death in patients with intractable hematological diseases requiring multiple red blood cell transfusions. Recently, deferasirox (DSX, a novel, once-daily oral iron chelator, was demonstrated to have similar efficacy to the conventional continuous infusion of deferoxamine on a decrease in serum ferritin (SF level in heavily transfused patients. We show three cases of transfusion-mediated iron-overloaded patients with an elevated serum alanine aminotransaminase (ALT. All three patients who received the ICT with DSX showed a decrease in ALT level in association with a decrease in SF level. It is suggested that DSX therapy could be considered to expect the improvement of liver damage for iron-overloaded patients with an abnormal ALT level.

  16. Effects of Short-Term Cognitive Remediation on Cognitive Dysfunction in Partially or Fully Remitted Individuals with Bipolar Disorder: Results of a Randomised Controlled Trial.

    Directory of Open Access Journals (Sweden)

    Kirsa M Demant

    Full Text Available Cognitive dysfunction is common in bipolar disorder (BD but is not sufficiently addressed by current treatments. Cognitive remediation (CR may improve cognitive function in schizophrenia but no randomised controlled trial has investigated this intervention in BD. The present study aimed to investigate the effects of CR on persistent cognitive dysfunction in BD.Patients with BD in partial remission with cognitive complaints were randomised to 12 weeks group-based CR (n=23 or standard treatment (ST (n=23. Outcomes were improved verbal memory (primary, sustained attention, executive and psychosocial function (secondary and additional measures of cognitive and psychosocial function (tertiary. Participants were assessed at baseline and weeks 12 and 26.Of the 46 randomised participants five dropped out and one was excluded after baseline. CR (n=18 had no effect on primary or secondary measures of cognitive or psychosocial function compared with ST (n=22. However, CR improved subjective sharpness at week 12, and quality of life and verbal fluency at week 26 follow-up (tertiary outcomes. Although the trial turned out to have suboptimal statistical power for the primary outcome analysis, calculation of the 95% confidence interval showed that it was highly unlikely that an increase in sample size would have rendered any beneficial effects of CR vs. ST on the verbal memory.Short-term group-based CR did not seem to improve overall cognitive or psychosocial function in individuals with BD in full or partial remission. The present findings suggest that that longer-term, more intensive and individualised CR may be necessary to improve cognition in BD.ClinicalTrials.gov NCT01457235.

  17. The catalytic diversity of zeolites: confinement and solvation effects within voids of molecular dimensions.

    Science.gov (United States)

    Gounder, Rajamani; Iglesia, Enrique

    2013-05-01

    chemical composition, thus enabling voids of a given size and shape to provide the "right fit" for a given elementary step, defined as that which minimizes Gibbs free energies of activation. Tighter confinement is preferred at low temperatures because enthalpic gains prevail over concomitant entropic losses, while looser fits are favored at high temperatures because entropy gains offset losses in enthalpic stabilization. Confinement and solvation by van der Waals forces are not directly involved in the making or breaking of strong chemical bonds; yet, they confer remarkable diversity to zeolites, in spite of their structural rigidity and their common aluminosilicate composition. A single zeolite can itself contain a range of local void environments, each with distinct reactivity and selectivity; as a result, varying the distribution of protons among these locations within a given framework or modifying a given location by partial occlusion of the void space can extend the range of catalytic opportunities for zeolites. Taken together with theoretical tools that accurately describe van der Waals interactions between zeolite voids and confined guests and with synthetic protocols that place protons or space-filling moieties at specific locations, these concepts promise to broaden the significant impact and catalytic diversity already shown by microporous solids.

  18. Adhesive analysis of voids in class II composite resin restorations at the axial and gingival cavity walls restored under in vivo versus in vitro conditions

    Science.gov (United States)

    Purk, John H.; Dusevich, Vladimir; Glaros, Alan; Eick, J. David

    2007-01-01

    Objectives Adhesive analysis, under the scanning electron microscope of microtensile specimens that failed through the adhesive interface, was conducted to evaluate the amount of voids present at the axial versus gingival cavity walls of class II composite restorations restored under in vivo and in vitro conditions. Methods Five patients received class II resin composite restorations, under in vivo and in vitro conditions. A total of 14 premolar teeth yielded 59 (n = 59) microtensile adhesive specimens that fractured through the adhesive interface. The fractured surfaces of all specimens were examined and the % area of voids was measured. Results Voids at the adhesive joint were highly predictive of bond strengths. An increase in the number of voids resulted in a decrease in the microtensile bond strength. The area of voids at the adhesive interface was as follows: in vivo axial 13.6 ± 25.6% (n = 12); in vivo gingival 48.8 ± 29.2% (n = 12); in vitro axial 0.0 ± 0.0% (n = 19) and in vitro gingival 11.7 ± 17.6% (n = 16). Significance Composite resin may bond differently to dentin depending upon the amount of voids and the cavity wall involved. The bond to the gingival wall was not as reliable as the bond to the axial wall. An increase in the amount of surface voids was a major factor for reducing microtensile bond strengths of adhesive to dentin. PMID:16950506

  19. Clusters, voids and reconstructions of the cosmic web

    Science.gov (United States)

    Bos, E. G. Patrick

    2016-12-01

    The Universe is filled for 95% with dark matter and energy that we cannot see. Of the remaining 5% normal matter we can only see a small part. However, if we want to study the Universe as a whole, we will have to get to know it for 100%. We have to uncover indirectly where dark matter is hiding and what is the nature of dark energy. In this thesis we explore two such methods. The first part describes how we can use the large empty regions between galaxies, "voids", to learn more about dark energy. We converted our theoretical simulations to a model of real observations of galaxies. In this model, we perform the same measurements as we would in real observations. This way, we show that it is indeed possible to unravel the nature of dark energy. The second part is based on our computer code: BARCODE. It unites two models: a physical model of the formation of the Cosmic Web, and a description of the observational effects of (clusters of) galaxies, in particular the effect of redshift on distance measurements. It allows us to back-trace our observations to the primordial conditions. These enable us to trace all (dark) matter, also that which we did not directly observe. The result is a reconstruction of the complete Cosmic Web. In these, we studied "filaments". These objects have not yet been extensively studied. BARCODE will enable further study, e.g. by using it to find observable filaments.

  20. [Development of remote wireless mobile voiding diary and a report of its objective voiding in 20 young people].

    Science.gov (United States)

    Guan, Zhi-chen; Wei, Ben-lin; Meng, Zuo-wei

    2010-08-18

    To find out the data of the micturitions in healthy young people with the remote & mobile voiding diary monitoring system. Twenty healthy young people were studied and ten of them were female. The ages ranged from 22 to 35 years (the mean age: 27.4 years). The females were 22-33 years old (the mean age: 26.4 years ) and the males 24-35 years old (the mean age: 28.4 years). With the remote & mobile voiding diary monitoring system, their voiding information was collected. Through bluetooth, the voiding information was sent to the patient's intelligent cell phone from the collector, then stored directly by intelligent cell phone and wirelessly transmitted to the workstation in the hospital. All of them completed the voiding diaries for 7 days and the data were analyzed. The average micturition of the young healthy people was 5.6 times (3.4-7.4) per 24 hours,in which 5.3 (3.4-7.3) times were in the daytime and 0.3 (0-1.3)times in the night. The functional voiding volume was 318 mL (66-642 mL). The mean voiding volume in 24 hours was 1 724 mL (1152-2 415 mL), in which 1 289 mL (786-2 039 mL) was in the daytime and 435 mL (292-805 mL) in the night. The mean drinking volume was 1 022 mL (453-1 721 mL) in the daytime and 7 mL (0-43 mL) in the night. The nocturia index (Ni) was 1.03, the nocturnal polyuria index (NPi) 26%, and the nocturnal bladder capacity index (NBCi) 0.27. The remote & mobile voiding diary monitoring system can help us get the objective voiding information from young health people for the first time. It is reliable, maneuverable and can be widely used in clinical diagnosis.

  1. Avoid a Void: The Eradication of Null Dereferencing

    Science.gov (United States)

    Meyer, Bertrand; Kogtenkov, Alexander; Stapf, Emmanuel

    All object-oriented programs, but also those in C or Pascal as soon as they use pointers, are subject to the risk of run-time crash due to "null pointer dereferencing". Until recently this was the case even in statically typed languages. Tony Hoare has called this problem his "billion-dollar mistake". In the type system of ISO-standard Eiffel, the risk no longer exists: void safety (the absence of null pointer dereferencing) has become a property guaranteed by the type system and enforced by the compiler. The mechanism is fully implemented and major libraries and applications have been made void-safe. This presentation describes the principles of Eiffel's void safety, their implementation and the lessons gained.

  2. On the void explanations of the Cold Spot

    CERN Document Server

    Marcos-Caballero, A; Martínez-González, E; Vielva, P

    2015-01-01

    The integrated Sachs-Wolfe (ISW) contribution induced on the cosmic microwave background by the presence of a supervoid as the one detected by Szapudi et al. (2015) is reviewed in this letter in order to check whether it could explain the Cold Spot (CS) anomaly. Two different models, previously used for the same purpose, are considered to describe the matter density profile of the void: a top hat function and a compensated profile produced by a Gaussian potential. The analysis shows that, even enabling ellipticity changes or different values for the dark-energy equation of state parameter $\\omega$, the ISW contribution due to the presence of the void does not reproduce the properties of the CS. Finally, the probability of alignment between the void and the CS is also questioned as an argument in favor of a physical connection between these two phenomena.

  3. Study of void sizes and loading configurations effects on shock initiation due to void collapse in heterogeneous energetic materials

    Science.gov (United States)

    Roy, Sidhartha; Rai, Nirmal; Udaykumar, H. S.

    2015-06-01

    In heterogeneous energetic materials, presence of porosity has been seen to increase its sensitivity towards shock initiation and ignition. Under the application of shock load, the viscoplastic deformation of voids and its collapse leads to the formation of local high temperature regions known as hot spots. The chemical reaction triggers at the hot spot depending on the local temperature and grows eventually leading to ignition and formation of detonation waves in the material. The temperature of the hot spot depends on various factors such as shock strength, void size, void arrangements, loading configuration etc. Hence, to gain deeper understanding on shock initiation and ignition study due to void collapse, a parametric study involving various factors which can affect the hot spot temperature is desired. In the current work, effects of void sizes, shock strength and loading configurations has been studied for shock initiation in HMX using massively parallel Eulerian code, SCIMITAR3D. The chemical reaction and decomposition for HMX has been modeled using Henson-Smilowitz multi step mechanism. The effect of heat conduction has also been taken into consideration. Ignition threshold criterion has been established for various factors as mentioned. The critical hot spot temperature and its size which can lead to ignition has been obtained from numerical experiments.

  4. Influence of Baseline Characteristics, Operative Conduct and Postoperative Course on 30-day Outcomes of Coronary Artery Bypass Grafting among Patients with Left Ventricular Dysfunction: Results from the Surgical Treatment for Ischemic Heart Failure (STICH) Trial

    Science.gov (United States)

    Wrobel, Krzysztof; Stevens, Susanna R.; Jones, Robert H.; Selzman, Craig H.; Lamy, Andre; Beaver, Thomas M.; Djokovic, Ljubomir T.; Wang, Nan; Velazquez, Eric J.; Sopko, George; Kron, Irving L.; DiMaio, J. Michael; Michler, Robert E.; Lee, Kerry L.; Yii, Michael; Leng, Chua Yeow; Zembala, Marian; Rouleau, Jean L.; Daly, Richard C.; Al-Khalidi, Hussein R.

    2015-01-01

    Background Patients with severe left ventricular (LV) dysfunction, ischemic heart failure and coronary artery disease (CAD) suitable for coronary artery bypass grafting (CABG) are at higher risk for surgical morbidity and mortality. Paradoxically, those patients with the most severe coronary artery disease and ventricular dysfunction who derive the greatest clinical benefit from CABG are also at the greatest operative risk, which makes decision-making regarding whether to proceed to surgery difficult in such patients. To better inform such decision-making, we analyzed the STICH CABG population for detailed information on perioperative risk and outcomes. Methods and Results In both STICH trials (hypotheses), 2136 patients with a left ventricular ejection fraction (LVEF) ≤ 35% and coronary artery disease were allocated to medical therapy, CABG plus medical therapy or CABG with surgical ventricular reconstruction (SVR). Relationships of baseline characteristics and operative conduct with morbidity and mortality at 30 days were evaluated. There were a total of 1460 patients who received surgery, and 346 of them (roughly, one-quarter) of these high-risk patients developed a severe complication within 30 days. Worsening renal insufficiency, cardiac arrest with cardiopulmonary resuscitation, and ventricular arrhythmias were the most frequent complications and those most commonly associated with death. Mortality at 30 days was 5.1% and was generally preceded by a serious complication (65 of 74 deaths). LV size, renal dysfunction, advanced age, and atrial fibrillation/flutter were significant preoperative predictors of mortality within 30 days. Cardiopulmonary bypass time was the only independent surgical variable predictive of 30-day mortality. Conclusions CABG can be performed with relatively low 30-day mortality in patients with LV dysfunction. Serious postoperative complications occurred in nearly 1 in 4 patients and were associated with mortality. Clinical Trial

  5. CMB anisotropies generated by cosmic voids and great attractors. [Cosmic microwave background

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Gonzalez, E.; Sanz, J.L. (Cantabria Univ., Santander (Spain). Dept. Fisica Moderna)

    1990-12-01

    A recent result, based on the potential approximation, concerning the effect of a non-static gravitational potential on the propagation of light, is used to study the influence of compensated and uncompensated non-linear structures on the cosmic microwave background radiation. We obtain the temperature profile as well as the deflection of the microwave photons produced by the cosmic voids and great attractors whose existence has recently been claimed in the literature. (author).

  6. Study of galaxies in the Lynx-Cancer void. VI. HI-observations with the Nancay Radio Telescope

    CERN Document Server

    Pustilnik, S A

    2016-01-01

    Context. Void population consists mainly of late-type and low surface brightness (LSB) dwarf galaxies whose atomic hydrogen is the main component of their baryonic matter. Therefore, observations of void galaxy HI are mandatory in order to understand their evolution and dynamics. Aims. Our aim was to obtain integrated HI parameters for a fainter part of the nearby Lynx-Cancer void galaxy sample (total of 45 objects) with the Nancay Radio Telescope (NRT) and to conduct the comparative analysis of all the 103 void galaxies with known HI data with a sample of similar galaxies residing in denser environments of the Local Volume. Methods. For HI observations we used the NRT with its sensitive antenna/receiver system FORT and standard processing. The comparison of the void and control samples on the parameter M(HI)/L_B is conducted with the non-parametric method `The 2x2 Contingency Table test'. Results. We obtained new HI data for about 40% of the Lynx-Cancer galaxy sample. Along with data from the literature, we ...

  7. Influence of root canal sealer on the radiographic appearance of filling voids in maxillary single-rooted teeth

    Directory of Open Access Journals (Sweden)

    Augusto Bodanezi

    2012-08-01

    Full Text Available OBJECTIVE: This study compared the influence of three epoxy resin-based sealers with distinct radiopacities on the observers' ability to detect root canal filling voids during radiographic analysis. MATERIAL AND METHODS: The root canals of 48 extracted maxillary canines were prepared and divided into three groups. Each group was laterally condensed with one sealer (AH Plus®, Acroseal® or a non-radiopaque sealer, and a longitudinal void was simulated in half of the specimens from each group (n=8. Buccolingual radiographs were obtained and randomly interpreted for voids by a radiologist and an endodontist in a blinded fashion. Teeth were cut and inspected under a microscope to confirm the position of void. Differences in sensitivity and specificity between groups and examiners were compared using the Fisher's Exact and McNemar tests, respectively (α=0.05. RESULTS: Significantly lower sensitivity levels (p<0.05 were observed in the coronal portion of fillings performed with both radiopaque sealers. Specificity values for Acroseal® were significantly higher (p<0.05 in the coronal and apical portions of fillings. CONCLUSIONS: The type of root canal sealer can affect the observers' ability to detect root canal filling voids during radiographic analysis of upper single-rooted teeth.

  8. Determination of the equivalent intergranular void ratio - Application to the instability and the critical state of silty sand

    Science.gov (United States)

    Nguyen, Trung-Kien; Benahmed, Nadia; Hicher, Pierre-Yves

    2017-06-01

    This paper presents an experimental study of mechanical response of natural Camargue silty sand. The analysis of test results used the equivalent intergranular void ratio instead of the global void ratio. The calculation of equivalent intergranular void ratio requires the determination of parameter b which represents, physically, the fraction of active fines participating on the chain forces network, hence the strength of the soil. A new formula for determining the parameter b by using an approach based on the coordination number distribution and probability calculation is proposed. The validation of the developed relationship was done through back-analysis of published datasets in literature on the effect of fines content on silty sand behavior. It is shown that the equivalent intergranular void ratio calculated with the b value obtained by the new formula is able to provide strong correlation to not only the critical state of but also the onset of instability of various silty sands, in different terms as peak deviator stress, peak stress ratio or cyclic resistance. Therefore, it is suggested that the use of the equivalent void ratio concept and the new b calculating formula is highly desirable in predicting of the silty sand behavior.

  9. Determination of the equivalent intergranular void ratio - Application to the instability and the critical state of silty sand

    Directory of Open Access Journals (Sweden)

    Nguyen Trung-Kien

    2017-01-01

    Full Text Available This paper presents an experimental study of mechanical response of natural Camargue silty sand. The analysis of test results used the equivalent intergranular void ratio instead of the global void ratio. The calculation of equivalent intergranular void ratio requires the determination of parameter b which represents, physically, the fraction of active fines participating on the chain forces network, hence the strength of the soil. A new formula for determining the parameter b by using an approach based on the coordination number distribution and probability calculation is proposed. The validation of the developed relationship was done through back-analysis of published datasets in literature on the effect of fines content on silty sand behavior. It is shown that the equivalent intergranular void ratio calculated with the b value obtained by the new formula is able to provide strong correlation to not only the critical state of but also the onset of instability of various silty sands, in different terms as peak deviator stress, peak stress ratio or cyclic resistance. Therefore, it is suggested that the use of the equivalent void ratio concept and the new b calculating formula is highly desirable in predicting of the silty sand behavior.

  10. Gamma-ray attenuation technique for measuring void fraction in horizontal gas-liquid two-phase flow

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The measurement of void fraction is of importance to the oil industry and chemical industry. In this article,the principle and mathematical method of determining the void fraction of horizontal gas-liquid flow by using a single-energy γ-ray system is described. The γ-ray source is the radioactive isotope of 241Am with γ-ray energy of 59.5 keV. The time-averaged value of the void fraction in a 50.0-mm i.d. transparent horizontal pipeline is measured under various combinations of the liquid flow and gas flow. It is found that increasing the gas flow rate at a fixed liquid flow rate would increase the void fraction. Test data are compared with the predictions of the correlations and a good agreement is found. The result shows that the designed γ-ray system can be used for measuring the void fraction in a horizontal gas-liquid two-phase flow with high accuracy.

  11. Assessment of void swelling in austenitic stainless steel PWR core internals.

    Energy Technology Data Exchange (ETDEWEB)

    Chung, H. M.; Energy Technology

    2006-01-31

    As many pressurized water reactors (PWRs) age and life extension of the aged plants is considered, void swelling behavior of austenitic stainless steel (SS) core internals has become the subject of increasing attention. In this report, the available database on void swelling and density change of austenitic SSs was critically reviewed. Irradiation conditions, test procedures, and microstructural characteristics were carefully examined, and key factors that are important to determine the relevance of the database to PWR conditions were evaluated. Most swelling data were obtained from steels irradiated in fast breeder reactors at temperatures >385 C and at dose rates that are orders of magnitude higher than PWR dose rates. Even for a given irradiation temperature and given steel, the integral effects of dose and dose rate on void swelling should not be separated. It is incorrect to extrapolate swelling data on the basis of 'progressive compounded multiplication' of separate effects of factors such as dose, dose rate, temperature, steel composition, and fabrication procedure. Therefore, the fast reactor data should not be extrapolated to determine credible void swelling behavior for PWR end-of-life (EOL) or life-extension conditions. Although the void swelling data extracted from fast reactor studies is extensive and conclusive, only limited amounts of swelling data and information have been obtained on microstructural characteristics from discharged PWR internals or steels irradiated at temperatures and at dose rates comparable to those of a PWR. Based on this relatively small amount of information, swelling in thin-walled tubes and baffle bolts in a PWR is not considered a concern. As additional data and relevant research becomes available, the newer results should be integrated with existing data, and the worthiness of this conclusion should continue to be scrutinized. PWR baffle reentrant corners are the most likely location to experience high swelling

  12. Thyroid dysfunction and subfertility.

    Science.gov (United States)

    Cho, Moon Kyoung

    2015-12-01

    The thyroid hormones act on nearly every cell in the body. Moreover, the thyroid gland continuously interacts with the ovaries, and the thyroid hormones are involved in almost all phases of reproduction. Thyroid dysfunctions are relatively common among women of reproductive age, and can affect fertility in various ways, resulting in anovulatory cycles, high prolactin levels, and sex hormone imbalances. Undiagnosed and untreated thyroid disease can be a cause of subfertility. Subclinical hypothyroidism (SCH), also known as mild thyroid failure, is diagnosed when peripheral thyroid hormone levels are within the normal reference laboratory range, but serum thyroid-stimulating hormone levels are mildly elevated. Thyroid autoimmunity (TAI) is characterized by the presence of anti-thyroid antibodies, which include anti-thyroperoxidase and anti-thyroglobulin antibodies. SCH and TAI may remain latent, asymptomatic, or even undiagnosed for an extended period. It has also been demonstrated that controlled ovarian hyperstimulation has a significant impact on thyroid function, particularly in women with TAI. In the current review, we describe the interactions between thyroid dysfunctions and subfertility, as well as the proper work-up and management of thyroid dysfunctions in subfertile women.

  13. Voiding patterns in men evaluated by a questionnaire survey

    DEFF Research Database (Denmark)

    Sommer, P; Nielsen, K K; Bauer, T;

    1990-01-01

    A questionnaire on obstructive and irritative voiding symptoms was sent to 572 men aged between 20 and 79 years, selected at random from the National Register; 337 questionnaires were completed. None of the responders had consulted a doctor because of voiding symptoms. There was a significant...... had symptoms equal in severity to those found in men undergoing prostatectomy; 29% and 11% of men in the eighth decade [corrected] had nocturia twice and 3 times or more respectively; 19% complained of urge incontinence. More information on possible treatment is needed....

  14. Effects of Heterogeneous Sink Distribution on Void Swelling

    DEFF Research Database (Denmark)

    Leffers, Torben; Volobuyev, A. V.; Gann, V. V.

    1986-01-01

    Swelling rates are calculated for two types of material with heterogeneous distributions of dislocations and voids, namely copper irradiated with neutrons to low dose at 250 degree C and heavily cold-worked copper irradiated with 1 MeV electrons in a HVEM at 250 degree C. Both materials...... are considered to consist of non-interacting spherical components with a wall and an inner cell with different dislocation and/or void densities. We subdivide the sphere (wall plus cell) in a number of concentric shells and find a quasi-static solution for the interstitial and vacancy concentrations...

  15. Plane wave propagation in a rotating anisotropic medium with voids under the action of a uniform magnetic field

    Science.gov (United States)

    Maity, Narottam; Barik, S. P.; Chaudhuri, P. K.

    2016-09-01

    In this paper, plane wave propagation in a rotating anisotropic material of general nature under the action of a magnetic field of constant magnitude has been investigated. The material is supposed to be porous in nature and contains voids. Following the concept of [Cowin S. C. and Nunziato, J. W. [1983] “Linear elastic materials with voids,” J. Elasticity 13, 125-147.] the governing equations of motion have been written in tensor notation taking account of rotation, magnetic field effect and presence of voids in the medium and the possibility of plane wave propagation has been examined. A number of particular cases have been derived from our general results to match with previously obtained results in this area. Effects of various parameters on the velocity of wave propagation have been presented graphically.

  16. Cognitive dysfunction in spinocerebellar ataxias

    Directory of Open Access Journals (Sweden)

    Helio Afonso Ghizoni Teive

    Full Text Available Abstract Spinocerebellar ataxias (SCAs comprise a heterogeneous group of complex neurodegenerative diseases, characterized by the presence of progressive cerebellar ataxia, associated or otherwise with ophthalmoplegia, pyramidal signs, extrapyramidal features, pigmentary retinopathy, peripheral neuropathy, cognitive dysfunction and dementia. Objective: To verify the presence of cognitive dysfunction among the main types of SCA described in the literature. Methods: the review was conducted using the search system of the PUBMED and OMIM databases. Results: Cognitive dysfunction occurs in a considerable proportion of SCA, particularly in SCA 3, which is the most frequent form of SCA worldwide. Dementia has been described in several other types of SCA such as SCA 2, SCA 17 and DRPLA. Mental retardation is a specific clinical feature of SCA 13. Conclusions: The role of the cerebellum in cognitive functions has been observed in different types of SCAs which can manifest varying degrees of cognitive dysfunction, dementia and mental retardation.

  17. Numerical simulation of the effect of void fraction and inlet velocity on two-phase turbulence in bubble-liquid flows

    Institute of Scientific and Technical Information of China (English)

    Lixing Zhou; Rongxian Li; Ruxu Du

    2006-01-01

    There are contradicted opinions on whether bubbles enhance or reduce the liquid turbulence. In this paper, the effect of void fraction and inlet velocity on the bubble-liquid two-phase turbulence of the multiple bubble-liquid jets in a two-dimensional channel is studied by using the two-phase second-order moment turbulence model. The results confirm the phenomena observed in experiments and reported in references that at a low void fraction and low inlet velocities the bubbles enhance the liquid turbulence, whereas at a high void fraction and high inlet velocities the bubbles reduce the liquid turbulence.

  18. Symptoms of Nerve Dysfunction After Hip Arthroscopy

    DEFF Research Database (Denmark)

    Dippmann, Christian; Thorborg, Kristian; Kraemer, Otto

    2014-01-01

    PURPOSE: The primary purpose of this study was to analyze the rate, pattern, and severity of symptoms of nerve dysfunction after hip arthroscopy (HA) by reviewing prospectively collected data. The secondary purpose was to study whether symptoms of nerve dysfunction were related to traction time...... year after HA concerning symptoms of nerve dysfunction, possible localization, and erectile dysfunction. Fifty patients participated and returned fully completed questionnaires. Patients reporting symptoms of nerve dysfunction 1 year after HA were re-examined. RESULTS: Twenty-three of 50 patients (46......%) reported symptoms of nerve dysfunction during the first week after HA; this was reduced to 14 patients (28%) after 6 weeks, 11 patients (22%) after 26 weeks, and 9 patients (18%) after 1 year. One patient experienced temporary erectile dysfunction. No difference in traction time between patients...

  19. Bed wetting - silent suffering: an approach to enuresis and voiding disorders in children.

    Science.gov (United States)

    Kanitkar, Madhuri; Ramamurthy, H Ravi

    2013-09-01

    Bed wetting or nocturnal enuresis is a common problem among children. It is either monosymptomatic or may be associated with a voiding disorder. Many factors may contribute towards enuresis such as developmental delay, heredity, inappropriate nocturnal anti diuretic hormone secretion and reduced bladder capacity. Any child presenting with bed-wetting should be evaluated for any underlying bladder dysfunction before labeling as monosymptomatic enuresis. The evaluation consists of structured bowel and bladder history, detailed clinical examination, frequency volume record and appropriate investigations. The frequency volume diary is an indispensible component of evaluation and helps in establishing diagnosis and tailoring therapy. The treatment of monosymptomatic enuresis consists of positive psychological support, alarms and medication (desmopressin/ anticholinergics/ imiprammine). Children with features of underlying bladder dysfunction, anatomical anomalies and neurological disorders should be referred to a pediatrician without delay. The outcome of therapy is usually rewarding but varies, depending on the underlying etiology, motivation, compliance and family support. The cure rates with alarms are better than with desmopressin in monosymptomatic enuresis. Timely and appropriate therapy yields better outcomes. Thus, a thorough, scientific and evidence based approach is essential in children presenting with bed-wetting.

  20. Sedation with midazolam for voiding cystourethrography in children: a randomised double-blind study

    Energy Technology Data Exchange (ETDEWEB)

    Stokland, E.; Jacobsson, B.; Ljung, B. [Dept. of Paediatric Radiology and Clinical Physiology, The Queen Silvia Children' s Hospital, Gothenburg (Sweden); Andreasson, S. [Dept. of Paediatric Anaesthesiology, The Queen Silvia Children' s Hospital, Gothenburg (Sweden); Jodal, U. [Dept. of Paediatrics, The Queen Silvia Children' s Hospital, Gothenburg (Sweden)

    2003-04-01

    Background: Sedation with midazolam facilitates the performance of diagnostic procedures in children, including voiding cystourethrography (VCUG). However, the influence of sedation on voiding and imaging results have not been adequately evaluated. Objective: Midazolam and placebo were compared to assess discomfort during VCUG and to evaluate if sedation influenced the outcome of the examination. Materials and methods: The study was prospective, randomized and double-blind, and included 95 children, 48 in the midazolam group (median age 2.2 years) and 47 in the placebo group (median age 3.2 years). The evaluation included the child's/parent's experience of the VCUG, as well as the examination results. Results: The children/parents in the midazolam group experienced the VCUG as less distressing compared to those in the placebo group (P < 0.001). Forty-six of 48 children sedated with midazolam could void during the imaging procedure compared to 38 of 47 children given placebo (NS). There was no difference in frequency or grade of vesicoureteric reflux or bladder emptying between the groups. Conclusions: When sedation is required to perform VCUG in children, midazolam can be used without negative effect on the outcome of the examination. (orig.)

  1. Passive monitoring for near surface void detection using traffic as a seismic source

    Science.gov (United States)

    Zhao, Y.; Kuzma, H. A.; Rector, J.; Nazari, S.

    2009-12-01

    In this poster we present preliminary results based on our several field experiments in which we study seismic detection of voids using a passive array of surface geophones. The source of seismic excitation is vehicle traffic on nearby roads, which we model as a continuous line source of seismic energy. Our passive seismic technique is based on cross-correlation of surface wave fields and studying the resulting power spectra, looking for "shadows" caused by the scattering effect of a void. High frequency noise masks this effect in the time domain, so it is difficult to see on conventional traces. Our technique does not rely on phase distortions caused by small voids because they are generally too tiny to measure. Unlike traditional impulsive seismic sources which generate highly coherent broadband signals, perfect for resolving phase but too weak for resolving amplitude, vehicle traffic affords a high power signal a frequency range which is optimal for finding shallow structures. Our technique results in clear detections of an abandoned railroad tunnel and a septic tank. The ultimate goal of this project is to develop a technology for the simultaneous imaging of shallow underground structures and traffic monitoring near these structures.

  2. Evolution of density and velocity profiles of matter in large voids

    CERN Document Server

    Tsizh, Maksym

    2016-01-01

    We analyse the evolution of cosmological perturbations which leads to the formation of large voids in the distribution of galaxies. We assume that perturbations are spherical and all components of the Universe - radiation, matter and dark energy - are continuous media with ideal fluid energy-momentum tensors, which interact only gravitationally. Equations of the evolution of perturbations in the comoving to cosmological background reference frame for every component are obtained from equations of conservation and Einstein's ones and are integrated by modified Euler method. Initial conditions are set at the early stage of evolution in the radiation-dominated epoch, when the scale of perturbation is mush larger than the particle horizon. Results show how the profiles of density and velocity of matter in spherical voids with different overdensity shells are formed.

  3. Formation of the spherical voids in the models of the universe with dark energy

    Science.gov (United States)

    Tsizh, M.; Novosyadlyj, B.

    2016-06-01

    We analyze evolution of cosmological perturbations which lead to the formation of large voids in the distribution of galaxies. We suppose that perturbations are spherical and main energetic components – radiation, matter and dark energy – are continuous media with ideal fluid energy-momentum tensors, which interact only gravitationally. Equations of the evolution of perturbations in the comoving to cosmological background reference frame for every component are obtained from equations of conservation and Einstein's ones and are integrated by modified Euler method with setting the initial conditions at the early stage of evolution in radiation-dominated epoch, when the scale of perturbation is mush larger than particle horizon. Obtained results illustrate dynamics of dark energy in the void region and its dependence on parameter of effective speed of sound of dark energy.

  4. Evolution of density and velocity profiles of matter in large voids

    Science.gov (United States)

    Tsizh, M.; Novosyadlyj, B.

    2016-09-01

    We analyse the evolution of cosmological perturbations which leads to the formation of large voids in the distribution of galaxies. We assume that perturbations are spherical and all components of the Universe - radiation, matter and dark energy - are continuous media with ideal fluid energy-momentum tensors, which interact only gravitationally. Equations of the evolution of perturbations in the comoving to cosmological background reference frame for every component are obtained from equations of conservation and Einstein's ones and are integrated by modified Euler method. Initial conditions are set at the early stage of evolution in the radiation-dominated epoch, when the scale of perturbation is mush larger than the particle horizon. Results show how the profiles of density and velocity of matter in spherical voids with different overdensity shells are formed.

  5. Void formation and microstructural development in oxide dispersion strengthened ferritic steels during electron-irradiation

    Science.gov (United States)

    Saito, J.; Suda, T.; Yamashita, S.; Ohnuki, S.; Takahashi, H.; Akasaka, N.; Nishida, M.; Ukai, S.

    1998-10-01

    ODS ferritic steels (13Cr-0.5Ti-0.2Y 2O 3) were prepared by the mechanical alloying method followed by the hot extrusion and several heat treatments including recrystallization. ODS steels with different heat treatment and a ferritic/martensitic (F/M) steel for the reference were irradiated to 12 dpa at 670-770 K in HVEM. After recrystallization, the dislocation density decreased with increasing grain size, however, the oxide particles did not show any obvious change in the size and the number density. During the electron-irradiation the microstructure was relatively stable, i.e. oxide particles showed good stability and the dislocation density remained almost constant. A limited void formation was observed in the specimens, and the suppressive effect due to dislocations with high number density was confirmed. From these results, the behavior of microstructure and the limited void formation in ODS steels have been discussed.

  6. Void and precipitate structure in ion- and electron-irradiated ferritic alloys

    Science.gov (United States)

    Ohnuki, Soumei; Takahashi, Heishichiro; Takeyama, Taro

    1984-05-01

    Void formation and precipitation were investigated in Fe10Cr and Fe13Cr base alloys by 200 keV C + ion and 1 MeV electron irradiation. The ferritic alloys exhibited significant resistance to void swelling. In FeCr and FeCr-Si alloys, ion-irradiation produced the precipitates of M 23C 6 type. In the FeCrTi alloy, Ti-rich precipitates were formed with high number density on {100} plane. During electron-irradiation Fe-10Cr alloy, complex dislocation loops were produced with high number density, of which Burgers vector was mostly . EDX analysis showed slightly enrichment of chromium on dislocation loops. These results suggested that the stability of type dislocation structure at high dose is an important factor on good swelling resistance in the ferritic alloys, moreover, titanium addition will intensify the stability of the doslocations through the fine precipitation on dislocations.

  7. Asymptotic analysis, polarization matrices and topological derivatives for piezoelectric materials with small voids

    CERN Document Server

    Cardone, G; Sokolowski, J

    2009-01-01

    Asymptotic formulae for the mechanical and electric fields in a piezoelectric body with a small void are derived and justified. Such results are new and useful for applications in the field of design of smart materials. In this way the topological derivatives of shape functionals are obtained for piezoelectricity. The asymptotic formulae are given in terms of the so-called polarization tensors (matrices) which are determined by the integral characteristics of voids. The distinguished feature of the piezoelectricity boundary value problems under considerations is the absence of positive definiteness of an differential operator which is non self-adjoint. Two specific Gibbs' functionals of the problem are defined by the energy and the electric enthalpy. The topological derivatives are defined in different manners for each of the governing functionals. Actually, the topological derivative of the enthalpy functional is local i.e., defined by the pointwise values of the governing fields, in contrary to the energy f...

  8. Cooperative Position Aware Mobility Pattern of AUVs for Avoiding Void Zones in Underwater WSNs

    Science.gov (United States)

    Javaid, Nadeem; Ejaz, Mudassir; Abdul, Wadood; Alamri, Atif; Almogren, Ahmad; Niaz, Iftikhar Azim; Guizani, Nadra

    2017-01-01

    In this paper, we propose two schemes; position-aware mobility pattern (PAMP) and cooperative PAMP (Co PAMP). The first one is an optimization scheme that avoids void hole occurrence and minimizes the uncertainty in the position estimation of glider’s. The second one is a cooperative routing scheme that reduces the packet drop ratio by using the relay cooperation. Both techniques use gliders that stay at sojourn positions for a predefined time, at sojourn position self-confidence (s-confidence) and neighbor-confidence (n-confidence) regions that are estimated for balanced energy consumption. The transmission power of a glider is adjusted according to those confidence regions. Simulation results show that our proposed schemes outperform the compared existing one in terms of packet delivery ratio, void zones and energy consumption. PMID:28335377

  9. TRANSVERSELY ISOTROPIC HYPER-ELASTIC MATERIAL RECTANGULAR PLATE WITH VOIDS UNDER A UNIAXIAL EXTENSION

    Institute of Scientific and Technical Information of China (English)

    程昌钧; 任九生

    2003-01-01

    The finite deformation and stress analyses for a transversely isotropic rectangularplate with voids and made of hyper-elastic material with the generalized neo-Hookean strainenergy function under a uniaxial extension are studied. The deformation functions of plateswith voids that are symmetrically distributed in a certain manner are given and the functionsare expressed by two parameters by solving the differential equations. The solution may beapproximately obtained from the minimum potential energy principle. Thus, the analyticsolutions of the deformation and stress of the plate are obtained. The growth of the void.s andthe distribution of stresses along the voids are analyzed and the influences of the degree ofanisotropy, the size of the voids and the distance between the voids are discussed. Thecharacteristics of the growth of the voids and the distribution of stresses of the plates with onevoid, three or five voids are obtained and compared.

  10. Shapes and Sizes of Voids in the LCDM Universe: Excursion Set Approach

    CERN Document Server

    Shandarin, S; Heitmann, K; Habib, S; Shandarin, Sergei; Feldman, Hume A.; Heitmann, Katrin

    2006-01-01

    We study the global distribution and morphology of dark matter voids in a LCDM universe using density fields generated by N-body simulations. Voids are defined as isolated regions of the low-density excursion set specified via density thresholds, the density thresholds being quantified by the corresponding filling factors, i.e., the fraction of the total volume in the excursion set. Our work encompasses a systematic investigation of the void volume function, the volume fraction in voids, and the fitting of voids to corresponding ellipsoids and spheres. We emphasize the relevance of the percolation threshold to the void volume statistics of the density field both in the high redshift, Gaussian random field regime, as well as in the present epoch. By using measures such as the Inverse Porosity, we characterize the quality of ellipsoidal fits to voids, finding that such fits are a poor representation of the larger voids that dominate the volume of the void excursion set.

  11. SURFACE EFFECT ON NANOSIZED VOID GROWTH IN A RIGID-PERFECTLY PLASTIC MATERIAL

    Institute of Scientific and Technical Information of China (English)

    Tong Hui; Yiheng Chen

    2008-01-01

    The influence of the surface effect on the nanosized spherical void growth in a rigid-perfectly plastic material is analyzed and the mechanism of the nanosized void growth with high triaxiality is given. Based on the Rice and Tracey model for a macro void growth, the present model is proposed to account for the nanosized void growth under a uniform remote strain rate field with consideration on the surface effect. It is concluded that the surface effect yields an evident resistant influence on the nanosized void growth. That is, this influence decays as the void radius increases. With high triaxiality, the nanosized void growth is divided into two stages:the initial stage and the mature stage. At the first stage, the void grows slowly and the influence of surface effect is relatively weak, whereas at the second stage, the influene is significant and the void grows drastically.

  12. THE CORRELATION OF RADIOLOGICAL EXAMINATION AND VOLITIONAL VOIDING IN THORACO - LUMBAR FRACTURES AND SPINAL INJURY

    Directory of Open Access Journals (Sweden)

    Mathangi Santhosh

    2015-04-01

    Full Text Available BACKGROUND: Spinal Cord Injury (SCI is a devastating medical condition which results in paraplegia with decreased bladder and bowel control. Investigation used to predict volitional voiding in persons with acute SCI include clinical examination, X - rays of the spine, CT scan, MRI, even though the later ones are not available in every medical center and all cannot afford. AIM: To determine if those with a mild narrowing of the vertebral canal have a better prognosis for volitional voiding. SETTINGS AND DESIGN: Prospective study of 20 consecutive patients with thoracolumbar fractures and spinal injury, admitted in the Department of Physical Medicine Rehabilitation, Christian Medical College, and Vellore within three weeks of injury, were recruited into the study. METHODS AND MATERIALS: Initial neurological examination was performed on admission and final between 16 - 20 weeks after the injury. Lateral and anteroposterior X - rays of the spine were done to measure the antero - posterior and transverse diameters of the spinal canal as well as the canal - body ratio at the level of the lesion. Bladder function was assessed between 16 - 20 weeks following the injury by Urodynamic study. The bladder outcome was divided into first category was assisted bladder emptying, which included intermittent catheterization, indwelling catheterization and second category was with volitional voiding. STATISTICAL ANALYSIS: D ata collection was subjected to statistical analysis using SPSS Version 11.0. Fisher’s exact test, Independent t - test and Mann - Whitney test were used. RESULTS AND CONCLUSIONS: The level of fracture did not correspond to the type of bladder. The use of Canal body ratio at the level of vertebral fracture on plain radiographs was not useful in prediction of volitional voiding. (P> 0.05. Therefore plain radiography was not found to be a good predictor of bladder function in persons with spinal injuries.

  13. Void effect analysis of Pb-208 of fast reactors with modified CANDLE burn-up scheme

    Science.gov (United States)

    Widiawati, Nina; Su'ud, Zaki

    2015-09-01

    Void effect analysis of Pb-208 as coolant of fast reactors with modified candle burn-up scheme has been conducted. Lead cooled fast reactor (LFR) is one of the fourth-generation reactor designs. The reactor is designed with a thermal power output of 500 MWt. Modified CANDLE burn-up scheme allows the reactor to have long life operation by supplying only natural uranium as fuel cycle input. This scheme introducing discrete region, the fuel is initially put in region 1, after one cycle of 10 years of burn up it is shifted to region 2 and region 1 is filled by fresh natural uranium fuel. The reactor is designed for 100 years with 10 regions arranged axially. The results of neutronic calculation showed that the void coefficients ranged from -0.6695443 % at BOC to -0.5273626 % at EOC for 500 MWt reactor. The void coefficients of Pb-208 more negative than Pb-nat. The results showed that the reactors with Pb-208 coolant have better level of safety than Pb-nat.

  14. Urine sensor device for fluoroscopy time reduction in pediatric voiding cystourethrography

    Energy Technology Data Exchange (ETDEWEB)

    Brook, O.R., E-mail: obrook@bidmc.harvard.edu [Department of Diagnostic Imaging, Rambam Health Care Campus, Haifa (Israel); Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215 (United States); Brook, A. [Department of Mathematics, Technion, Haifa (Israel); Soudack, M. [Pediatric Radiology Unit, Department of Diagnostic Imaging, Tel Hashomer Medical Center (Israel)

    2011-06-15

    Purpose: We evaluated the feasibility of a using urine sensor for voiding cystourethrography (VCUG) and its implications for fluoroscopy time reduction. Materials and methods: Institutional Review Board approved the study protocol. Study population included children less than 5 years old referred to our institution for VCUG. Patients with known vesicoureteral reflux or any pacing device were excluded from the study. The urine sensor consists of an electrode that senses the fluid, an electrical circuit and an indicator to provide visual signal. The urine sensor electrode was placed on the medial thigh in the proximity of the catheter close to the urethral opening, but without direct contact to it. A standard VCUG examination was performed with retrograde filling of the urinary bladder. Once the bladder was full, fluoroscopy of the voiding stage was initiated when the indicator blinked. Peak kV and fluoroscopy time were recorded. Results: Seven patients underwent VCUG with urine sensor and 22 patients without urine sensor. The urine sensor provided a reliable indication of voiding onset. The fluoroscopy time was significantly shorter with urine sensor use (1.99 min) than without urine sensor use (4.33 min) (p = 0.001). In patients with normal VCUG, fluoroscopy time was also significantly shorter with urine sensor use (2.13 min) than without urine sensor use (4.39 min) (p < 0.001). Conclusion: VCUG studies with the help of the urine sensor are feasible and its use may result in significant reduction in fluoroscopy time.

  15. The use of waveguide acoustic probes for void fraction measurement in the evaporator of BN-350-Type reactor

    Energy Technology Data Exchange (ETDEWEB)

    Melnikov, V.I.; Nigmatulin, B.I.

    1995-09-01

    The present paper deals with some results of the experimental studies which have been carried out to investigate the steam generation dynamics in the Field tubes of sodium-water evaporators used in the BN-350 reactors. The void fraction measurements have been taken with the aid of waveguide acoustic transducers manufactured in accordance with a specially designed technology (waveguide acoustic transducers-WAT technology). Presented in this paper also the transducer design and calibration methods, as well as the diagram showing transducers arrengment in the evaporator. The transducers under test featured a waveguide of about 4 m in length and a 200-mm long sensitive element (probe). Besides, this paper specifies the void fraction data obtained through measurements in diverse points of the evaporator. The studies revealed that the period of observed fluctuations in the void fraction amounted to few seconds and was largely dependent on the level of water in the evaporator.

  16. STATUS KUALITAS PERAIRAN DAN BIOTA PADA BEKAS GALIAN TAMBANG (VOID TERTUTUP PIT 4 PINANG KECAMATAN SUNGAI PINANG KABUPATEN BANJAR

    Directory of Open Access Journals (Sweden)

    Yunadar Yunandar

    2016-10-01

    Full Text Available This research aimed to analyzed conditions and water quality’s status void pit 4 Pinang with compared vertical level depth. Methods used ANOVA-One Way for compared contributed physical and chemical water between station and combined stándar baku mutu PP 82/2001. The results obtained that self purification process for fixed void and temperature, TSS, DO, COD, N, Hg and Fe on surface water are all station, sig. anova TSS, COD (0.000 ά = 5% compared temperature, TSS, DO, COD, N and Fe on 20 meters depth. Dominance TSS as limiting factor void for photosynthesis. Genera Oscillatoria indicated water polluted more environment index (diversity, dominance, Eveness over polluted status.Temperature, TSS, DO, COD, N and P suitable for biota’s live and baku mutu air class III uses for aquaculture, irigation, and agriculture.

  17. Thyroid dysfunction and pregnancy outcomes

    Science.gov (United States)

    Nazarpour, Sima; Ramezani Tehrani, Fahimeh; Simbar, Masoumeh; Azizi, Fereidoun

    2015-01-01

    Background: Pregnancy has a huge impact on the thyroid function in both healthy women and those that have thyroid dysfunction. The prevalence of thyroid dysfunction in pregnant women is relatively high. Objective: The objective of this review was to increase awareness and to provide a review on adverse effect of thyroid dysfunction including hyperthyroidism, hypothyroidism and thyroid autoimmune positivity on pregnancy outcomes. Materials and Methods: In this review, Medline, Embase and the Cochrane Library were searched with appropriate keywords for relevant English manuscript. We used a variety of studies, including randomized clinical trials, cohort (prospective and retrospective), case-control and case reports. Those studies on thyroid disorders among non-pregnant women and articles without adequate quality were excluded. Results: Overt hyperthyroidism and hypothyroidism has several adverse effects on pregnancy outcomes. Overt hyperthyroidism was associated with miscarriage, stillbirth, preterm delivery, intrauterine growth retardation, low birth weight, preeclampsia and fetal thyroid dysfunction. Overt hypothyroidism was associated with abortion, anemia, pregnancy-induced hypertension, preeclampsia, placental abruption, postpartum hemorrhage, premature birth, low birth weight, intrauterine fetal death, increased neonatal respiratory distress and infant neuro developmental dysfunction. However the adverse effect of subclinical hypothyroidism, and thyroid antibody positivity on pregnancy outcomes was not clear. While some studies demonstrated higher chance of placental abruption, preterm birth, miscarriage, gestational hypertension, fetal distress, severe preeclampsia and neonatal distress and diabetes in pregnant women with subclinical hypothyroidism or thyroid autoimmunity; the other ones have not reported these adverse effects. Conclusion: While the impacts of overt thyroid dysfunction on feto-maternal morbidities have been clearly identified and its long

  18. Thyroid dysfunction and pregnancy outcomes

    Directory of Open Access Journals (Sweden)

    Sima Nazarpour

    2015-07-01

    Full Text Available Background: Pregnancy has a huge impact on the thyroid function in both healthy women and those that have thyroid dysfunction. The prevalence of thyroid dysfunction in pregnant women is relatively high. Objective: The objective of this review was to increase awareness and to provide a review on adverse effect of thyroid dysfunction including hyperthyroidism, hypothyroidism and thyroid autoimmune positivity on pregnancy outcomes. Materials and Methods: In this review, Medline, Embase and the Cochrane Library were searched with appropriate keywords for relevant English manuscript. We used a variety of studies, including randomized clinical trials, cohort (prospective and retrospective, case-control and case reports. Those studies on thyroid disorders among non-pregnant women and articles without adequate quality were excluded. Results: Overt hyperthyroidism and hypothyroidism has several adverse effects on pregnancy outcomes. Overt hyperthyroidism was associated with miscarriage, stillbirth, preterm delivery, intrauterine growth retardation, low birth weight, preeclampsia and fetal thyroid dysfunction. Overt hypothyroidism was associated with abortion, anemia, pregnancy-induced hypertension, preeclampsia, placental abruption, postpartum hemorrhage, premature birth, low birth weight, intrauterine fetal death, increased neonatal respiratory distress and infant neuro developmental dysfunction. However the adverse effect of subclinical hypothyroidism, and thyroid antibody positivity on pregnancy outcomes was not clear. While some studies demonstrated higher chance of placental abruption, preterm birth, miscarriage, gestational hypertension, fetal distress, severe preeclampsia and neonatal distress and diabetes in pregnant women with subclinical hypothyroidism or thyroid autoimmunity; the other ones have not reported these adverse effects. Conclusion: While the impacts of overt thyroid dysfunction on feto-maternal morbidities have been clearly

  19. Impact on liquids : void collapse and jet formation

    NARCIS (Netherlands)

    Gekle, Stephan

    2009-01-01

    A spectacular example of free surface flow is the impact of a solid object on a liquid: At impact a “crown” splash is created and a surface cavity (void) emerges which immediately starts to collapse due to the hydrostatic pressure of the surrounding liquid. Eventually the cavity closes in a single

  20. Kinetic Monte Carlo simulations of void lattice formation during irradiation

    Science.gov (United States)

    Heinisch, H. L.; Singh, B. N.

    2003-11-01

    Over the last decade, molecular dynamics simulations of displacement cascades have revealed that glissile clusters of self-interstitial crowdions are formed directly in cascades and that they migrate one-dimensionally along close-packed directions with extremely low activation energies. Occasionally, under various conditions, a crowdion cluster can change its Burgers vector and glide along a different close-packed direction. The recently developed production bias model (PBM) of microstructure evolution under irradiation has been structured specifically to take into account the unique properties of the vacancy and interstitial clusters produced in the cascades. Atomic-scale kinetic Monte Carlo (KMC) simulations have played a useful role in understanding the defect reaction kinetics of one-dimensionally migrating crowdion clusters as a function of the frequency of direction changes. This has made it possible to incorporate the migration properties of crowdion clusters and changes in reaction kinetics into the PBM. In the present paper we utilize similar KMC simulations to investigate the significant role that crowdion clusters can play in the formation and stability of void lattices. The creation of stable void lattices, starting from a random distribution of voids, is simulated by a KMC model in which vacancies migrate three-dimensionally and self-interstitial atom (SIA) clusters migrate one-dimensionally, interrupted by directional changes. The necessity of both one-dimensional migration and Burgers vectors changes of SIA clusters for the production of stable void lattices is demonstrated, and the effects of the frequency of Burgers vector changes are described.

  1. A cosmic watershed : the WVF void detection technique

    NARCIS (Netherlands)

    Platen, Erwin; van de Weygaert, Rien; Jones, Bernard J. T.

    2007-01-01

    On megaparsec scales the Universe is permeated by an intricate filigree of clusters, filaments, sheets and voids, the cosmic web. For the understanding of its dynamical and hierarchical history it is crucial to identify objectively its complex morphological components. One of the most characteristic

  2. Structural control of void formation in dual phase steels

    DEFF Research Database (Denmark)

    Azuma, Masafumi

    measurements, tensile tests and hole-expansion tests. The initial microstructure and the deformed microstructure were characterized by means of scanning electron microscopy (SEM) and transmission electron microscopy (TEM). In situ tensile tests in a SEM were applied for direct observation of the void formation...

  3. Impact on liquids : void collapse and jet formation

    NARCIS (Netherlands)

    Gekle, Stephan

    2009-01-01

    A spectacular example of free surface flow is the impact of a solid object on a liquid: At impact a “crown” splash is created and a surface cavity (void) emerges which immediately starts to collapse due to the hydrostatic pressure of the surrounding liquid. Eventually the cavity closes in a single p

  4. Predictive efficacy of radioisotope voiding cystography for renal outcome

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seok Ki; Lee, Dong Soo; Kim, Kwang Myeung; Choi, Whang; Chung, June Key; Lee, Myung Chul [Seoul National Univ. College of Medicine, Seoul (Korea, Republic of)

    2000-04-01

    As vesicoureteral reflux (VUR) could lead to renal functional deterioration when combined with urinary tract infection, we need to decide whether operative anti-reflux treatment should be performed at the time of diagnosis of VUR. Predictive value of radioisotope voiding cystography (RIVCG) for renal outcome was tested. In 35 children (18 males, 17 females), radiologic voiding cystoure-thrography (VCU), RIVCG and DMSA scan were performed. Change in renal function was evaluated using the follow-up DMSA scan, ultrasonography, and clinical information. Discriminant analysis was performed using individual or integrated variables such as reflux amount and extent at each phase of voiding on RIVCG, in addition to age, gender and cortical defect on DMSA scan at the time of diagnosis. Discriminant function was composed and its performance was examined. Reflux extent at the filling phase and reflux amount and extent at postvoiding phase had a significant prognostic value. Total reflux amount was a composite variable to predict prognosis. Discriminant function composed of reflux extent at the filling phase and reflux amount and extent at postvoiding phase showed better positive predictive value and specificity than conventional reflux grading. RIVCG could predict renal outcome by disclosing characteristic reflux pattern during various voiding phases.

  5. The Effect of Random Voids in the Modified Gurson Model

    Science.gov (United States)

    Fei, Huiyang; Yazzie, Kyle; Chawla, Nikhilesh; Jiang, Hanqing

    2012-02-01

    The porous plasticity model (usually referred to as the Gurson-Tvergaard-Needleman model or modified Gurson model) has been widely used in the study of microvoid-induced ductile fracture. In this paper, we studied the effects of random voids on the porous plasticity model. Finite-element simulations were conducted to study a copper/tin/copper joint bar under uniaxial tension using the commercial finite-element package ABAQUS. A randomly distributed initial void volume fraction with different types of distribution was introduced, and the effects of this randomness on the crack path and macroscopic stress-strain behavior were studied. It was found that consideration of the random voids is able to capture more detailed and localized deformation features, such as different crack paths and different ultimate tensile strengths, and meanwhile does not change the macroscopic stress-strain behavior. It seems that the random voids are able to qualitatively explain the scattered observations in experiments while keeping the macroscopic measurements consistent.

  6. A halo bias function measured deeply into voids without stochasticity

    CERN Document Server

    Neyrinck, Mark C; Jeong, Donghui; Wang, Xin

    2013-01-01

    We study the relationship between dark-matter haloes and matter in the MIP N-body simulation ensemble, which allows precision measurements of this relationship, even deeply into voids. What enables this is a lack of discreteness, stochasticity, and exclusion, achieved by averaging over hundreds of possible sets of initial small-scale modes, while holding fixed large-scale modes that give the cosmic web. We find (i) that dark-matter-halo formation is greatly suppressed in voids; there is an exponential downturn at low densities in the otherwise power-law matter-to-halo density bias function. Thus, the rarity of haloes in voids is akin to the rarity of the largest clusters, and their abundance is quite sensitive to cosmological parameters. The exponential downturn appears both in an excursion-set model, and in a new model in which fluctuations evolve in voids as in an open universe with an effective Omega_m proportional to a large-scale density. We also find that (ii) haloes typically populate the average halo-...

  7. Electric field theory and the fallacy of void capacitance

    DEFF Research Database (Denmark)

    McAllister, Iain Wilson

    1991-01-01

    The concept of the capacitance of a gaseous void is discussed as applied to electrical insulation science. The most pertinent aspect of the capacitance definition is that of reference to a single-valued potential difference between surfaces. This implies that these surfaces must be surfaces...

  8. Excursion Sets and Non-Gaussian Void Statistics

    CERN Document Server

    D'Amico, Guido; Noreña, Jorge; Paranjape, Aseem

    2010-01-01

    Primordial non-Gaussianity (NG) affects the large scale structure (LSS) of the universe by leaving an imprint on the distribution of matter at late times. Much attention has been focused on using the distribution of collapsed objects (i.e. dark matter halos and the galaxies and galaxy clusters that reside in them) to probe primordial NG. An equally interesting and complementary probe however is the abundance of extended underdense regions or voids in the LSS. The calculation of the abundance of voids using the excursion set formalism in the presence of primordial NG is subject to the same technical issues as the one for halos, which were discussed e.g. in arXiv:1005.1203. However, unlike the excursion set problem for halos which involved random walks in the presence of one barrier $\\delta_c$, the void excursion set problem involves two barriers $\\delta_v$ and $\\delta_c$. This leads to a new complication introduced by what is called the "void-in-cloud" effect discussed in the literature, which is unique to the...

  9. Impact on liquids : void collapse and jet formation

    NARCIS (Netherlands)

    Gekle, Stephan

    2009-01-01

    A spectacular example of free surface flow is the impact of a solid object on a liquid: At impact a “crown” splash is created and a surface cavity (void) emerges which immediately starts to collapse due to the hydrostatic pressure of the surrounding liquid. Eventually the cavity closes in a single p

  10. The cosmic web in CosmoGrid void regions

    NARCIS (Netherlands)

    Rieder, Steven; van de Weygaert, Rien; Cautun, Marius; Beygu, Burcu; Portegies Zwart, Simon

    2016-01-01

    We study the formation and evolution of the cosmic web, using the high-resolution CosmoGrid ΛCDM simulation. In particular, we investigate the evolution of the large-scale structure around void halo groups, and compare this to observations of the VGS-31 galaxy group, which consists of three interact

  11. Calculation of Void in the Fort Saint Vrain Material

    Energy Technology Data Exchange (ETDEWEB)

    Potter, David Charles [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Taylor, Craig Michael [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Coons, James Elmer [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-05-11

    The percent void of the Fort Saint Vrain (FSV) material is estimated to be 21.1% based on the volume of the gap at the top of the drums, the volume of the coolant channels in the FSV fuel element, and the volume of the fuel handling channel in the FSV fuel element.

  12. The Aspen–Amsterdam Void Finder Comparison Project

    NARCIS (Netherlands)

    Colberg, J¨org M.; Pearce, Frazer; Foster, Caroline; Platen, Erwin; Brunino, Riccardo; Neyrinck, Mark; Basilakos, Spyros; Faira, Anthony; Feldman, Hume; Gottlöber, Stefan; Hahn, Oliver; Hoyle, Fiona; M¨uller, V.; Nelson, Lorne; Plionis, Manolis; Porciani, Cristiano; Shandarin, Sergei; Vogeley, Michael S.; Weygaert, Rien van de

    2008-01-01

    Despite a history that dates back at least a quarter of a century studies of voids in the large–scale structure of the Universe are bedevilled by a major problem: there exist a large number of quite different void–finding algorithms, a fact that has so far got in the way of groups comparing their

  13. Low-void polyimide resins for autoclave processing

    Science.gov (United States)

    Jones, R. J.; Vaughan, R. W.

    1972-01-01

    Development of an advanced A-type polyimide, which can be used to produce autoclave molded, low-void content composites suitable for use at temperatures up to 316 C is reported. It consists of a mixture of methyl nadic anhydride, an 80:20 molar ratio of methylene dianaline and thiodianilene, and pyromellitic dianhydride.

  14. Answers from the Void: VIDE and its Applications

    Science.gov (United States)

    Sutter, P. M.; Hamaus, N.; Pisani, A.; Lavaux, G.; Wandelt, B. D.

    2016-10-01

    We discuss various applications ofvide, the Void IDentification and Examination toolkit, anopen-source Python/C++ code for finding cosmic voids in galaxy redshift surveysand $N$-body simulations.Based on a substantially enhanced version of ZOBOV, vide not only finds voids, but alsosummarizes their properties, extracts statisticalinformation, and providesa Python-based platform for more detailed analysis, such asmanipulating void catalogs and particle members, filtering, plotting,computing clustering statistics, stacking, comparing catalogs, andfitting density profiles.vide also provides significant additional functionality forpre-processing inputs: for example, vide can work with volume- ormagnitude-limited galaxy samples with arbitrary survey geometries,or darkmatter particles or halo catalogs in a variety of common formats.It can also randomly subsample inputsand includes a Halo Occupation Distribution model forconstructing mock galaxy populations.vide has been used for a wide variety of applications, fromdiscovering a universal density profile to estimatingprimordial magnetic fields, andis publicly available athttp://bitbucket.org/cosmicvoids/vide\\_publicandhttp://www.cosmicvoids.net.

  15. Female Sexual Dysfunction

    Science.gov (United States)

    ... Endocrinologist Search Featured Resource Menopause Map™ View Female Sexual Dysfunction February 2012 Download PDFs English Espanol Editors ... Resources Mayo Clinic Cleveland Clinic What is female sexual dysfunction (FSD)? Many women have a low sex ...

  16. Void structure and density change of vanadium-base alloys irradiated in the dynamic helium charging experiment

    Energy Technology Data Exchange (ETDEWEB)

    Chung, H.M.; Nowicki, L.; Gazda, J. [Argonne National Lab., Chicago, IL (United States)] [and others

    1995-04-01

    The objective of this work is to determine void structure, distribution, and density changes of several promising vanadium-base alloys irradiated in the Dynamic Helium Charging Experiment (DHCE). Combined effects of dynamically charged helium and neutron damage on density change, void distribution, and microstructural evolution of V-4Cr-4Ti alloy have been determined after irradiation to 18-31 dpa at 425-600{degree}C in the DHCE, and the results compared with those from a non-DHCE in which helium generation was negligible.

  17. STATUS KUALITAS PERAIRAN DAN BIOTA PADA BEKAS GALIAN TAMBANG (VOID) TERTUTUP PIT 4 PINANG KECAMATAN SUNGAI PINANG KABUPATEN BANJAR

    OpenAIRE

    Yunadar Yunandar

    2016-01-01

    This research aimed to analyzed conditions and water quality’s status void pit 4 Pinang with compared vertical level depth. Methods used ANOVA-One Way for compared contributed physical and chemical water between station and combined stándar baku mutu PP 82/2001. The results obtained that self purification process for fixed void and temperature, TSS, DO, COD, N, Hg and Fe on surface water are all station, sig. anova TSS, COD (0.000) ά = 5% compared temperature, TSS, DO, COD, N and Fe on 20 met...

  18. Cyclic voiding cystouretrography without the use of fluoroscopic monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Kadioglu, Alev [ALKA Medical Imaging Center, Buyukdere Cad. Levent Apt. No: 36/16, 80200-Mecidiyekoy, Istanbul (Turkey)]. E-mail: alevkadioglu@yahoo.com; Mihmanli, Ismail [Istanbul University, Cerrahpasa Medical Faculty, Department of Radiology, 34300-Istanbul (Turkey); Kantarci, Fatih [Istanbul University, Cerrahpasa Medical Faculty, Department of Radiology, 34300-Istanbul (Turkey); Tekes, Aylin [ALKA Medical Imaging Center, Buyukdere Cad. Levent Apt. No: 36/16, 80200-Mecidiyekoy, Istanbul (Turkey); Uysal, Omer [Istanbul University, Cerrahpasa Medical Faculty, Department of Biostatistics, 34300-Istanbul (Turkey)

    2006-01-15

    Purpose: To determine whether cyclic voiding cystourethrography (VCUG) examinations can be performed without using real-time fluoroscopic monitoring. Materials and methods: VCUG examinations were performed in 209 children (133 girls and 76 boys). In each child, it was performed in a cyclic manner (three consecutive cycles) without using fluoroscopic monitoring and one radiograph was taken in each cycle of the examination. All patients were sedated by midazolam prior to examination. The degree of vesicoureteric reflux (VUR) was graded for each of the kidney ureter units (KUU) (total 418 KUU) separately. Statistical analysis included the comparison of the presence and absence of VUR and three ordinal-matched comparisons of each cycle. Results: VCUG was detected in 37.3% of the children (78/209) and 28.7% (120/418) of the KUU. The absence of or same degree of VUR in three consecutive cycles were obtained in 345 KUU and the agreement was calculated as 82.5%. The same degree and presence of reflux were found in 85 and 89 refluxing KUU, the same negative findings (absence of VUR) in 306 and 298 KUU, and discordant findings in 27 and 31 KUU (between the first and second and between first and third cycles), respectively. Therefore, the agreement was 93.5 and 92.5% between the first and second cycles (p = 0.70) and between the first and the third cycles (p = 0.15), respectively. Conclusion: Both the cyclic nature of this study and the results indicated that VCUG without real-time fluoroscopic monitoring could be used where adequate fluoroscopic examination is not possible for children in whom VUR detection is necessary and impacts treatment. However, the responsibility of pediatric radiologist always must also include the task to provide proper equipment for imaging children with suspected VUR.

  19. Differences in urodynamic voiding variables recorded by conventional cystometry and ambulatory monitoring in symptomatic women

    Directory of Open Access Journals (Sweden)

    Juan Pablo Valdevenito

    2014-10-01

    Full Text Available Objectives To determine whether there are differences in pressure and flow measurements between conventional cystometry (CONV and ambulatory urodynamic monitoring (AMB in women with overactive bladder syndrome and urinary incontinence. Materials and Methods Retrospective study which included female subjects who underwent both CONV (with saline filling medium and AMB, separated by less than 24 months, not using medication active on the lower urinary tract and without history of prior pelvic surgery. Both tests were carried out in compliance with the International Continence Society standards. The paired Student’s t test was used to compare continuous variables. Bland-Altman statistics were used to assess the agreement of each variable between both studies. Results Thirty women with a median (range age of 50 (14 - 73 years met the inclusion criteria. AMB was carried out at a mean (SD of 11 (6 months after CONV. Measurements of pves and pabd at the end of filling, and Qmax were significantly higher from AMB recordings. There were no differences in pdet at the end of filling, pdetQmax or pdetmax during voiding, nor significant difference in Vvoid. Conclusions We provide previously undocumented comparative voiding data between CONV and AMB for patients who most commonly require both investigations. Our findings show higher values of Qmax but similar values of pdetQmax measured by AMB which may partly reflect an overall lower catheter caliber, physiological filling but perhaps also more ‘normal’ voiding conditions.

  20. An Optimal Cure Process to Minimize Residual Void and Optical Birefringence for a LED Silicone Encapsulant

    Directory of Open Access Journals (Sweden)

    Min-Jae Song

    2014-05-01

    Full Text Available Silicone resin has recently attracted great attention as a high-power Light Emitting Diode (LED encapsulant material due to its good thermal stability and optical properties. In general, the abrupt curing reaction of the silicone resin for the LED encapsulant during the curing process induces reduction in the mechanical and optical properties of the LED product due to the generation of residual void and moisture, birefringence, and residual stress in the final formation. In order to prevent such an abrupt curing reaction, the reduction of residual void and birefringence of the silicone resin was observed through experimentation by introducing the multi-step cure processes, while the residual stress was calculated by conducting finite element analysis that coupled the heat of cure reaction and cure shrinkage. The results of experiment and analysis showed that it was during the three-step curing process that the residual void, birefringence, and residual stress reduced the most in similar tendency. Through such experimentation and finite element analysis, the study was able to confirm that the optimization of the LED encapsulant packaging process was possible.