WorldWideScience

Sample records for vocational progression pathways

  1. Crossing Campuses: Level 3 Tutor Visits and Vocational Progression

    Science.gov (United States)

    Thomas, Kate; Waring, Ruth

    2012-01-01

    This article focuses on a Western Vocational Lifelong Learning Network (WVLLN) initiative aimed at supporting Level 3 vocational tutors in further education (FE) who have moved into a teaching career via professional experience rather than through higher education (HE), but who play a significant role in advising young people about progression to…

  2. Finnish WorldSkills Achievers’ Vocational Talent Development and School-to-Work Pathways

    Directory of Open Access Journals (Sweden)

    Laura Pylväs

    2017-08-01

    Full Text Available This paper examines the perceptions of vocational expertise and school-to-work pathways among WorldSkills Competition (WSC achievers and their co-workers and employers within the Finnish context. At the biennial international WSC, young people (aged 18-to-23 years from over 60 countries demonstrate their skills in more than 40 trades. Individualized training for this competition is provided through the cooperation of vocational institutions (e.g., expert coaches, team leaders and competition panellists and industry (e.g., mentors, sponsors, materials, equipment. Semi-structured thematic interviews (N=51 were conducted in 2013 and 2014 with former Finnish WSC medal or diploma winners (n=18 who had since begun their working lives (1-to-15 years of work experience. Their employers (n=16 and colleagues (n=17 were also interviewed. Results showed that in addition to vocation-specific knowledge and skills, problem-solving skills, creativity, social skills and self-regulatory skills were acknowledged as the most significant elements of vocational expertise. The findings also indicated that formal vocational education combined with deliberate practice and training based on expert mentoring improved the long-term career progress and vocational expertise of the WSC achievers.

  3. Modeling cancer progression via pathway dependencies.

    Directory of Open Access Journals (Sweden)

    Elena J Edelman

    2008-02-01

    Full Text Available Cancer is a heterogeneous disease often requiring a complexity of alterations to drive a normal cell to a malignancy and ultimately to a metastatic state. Certain genetic perturbations have been implicated for initiation and progression. However, to a great extent, underlying mechanisms often remain elusive. These genetic perturbations are most likely reflected by the altered expression of sets of genes or pathways, rather than individual genes, thus creating a need for models of deregulation of pathways to help provide an understanding of the mechanisms of tumorigenesis. We introduce an integrative hierarchical analysis of tumor progression that discovers which a priori defined pathways are relevant either throughout or in particular steps of progression. Pathway interaction networks are inferred for these relevant pathways over the steps in progression. This is followed by the refinement of the relevant pathways to those genes most differentially expressed in particular disease stages. The final analysis infers a gene interaction network for these refined pathways. We apply this approach to model progression in prostate cancer and melanoma, resulting in a deeper understanding of the mechanisms of tumorigenesis. Our analysis supports previous findings for the deregulation of several pathways involved in cell cycle control and proliferation in both cancer types. A novel finding of our analysis is a connection between ErbB4 and primary prostate cancer.

  4. Support from Teachers and Trainers in Vocational Education and Training: The Pathways to Career Aspirations and Further Career Development

    Science.gov (United States)

    Hofmann, Claudia; Stalder, Barbara E.; Tschan, Franziska; Häfeli, Kurt

    2014-01-01

    Transition from school to work is a challenging period for young people with learning difficulties. In the dual vocational system of Switzerland, teachers at vocational educational and training (VET)-schools, as well as trainers at VET-companies, provide important support. We were interested in the different pathways from this support to…

  5. NOTCH pathway inactivation promotes bladder cancer progression.

    Science.gov (United States)

    Maraver, Antonio; Fernandez-Marcos, Pablo J; Cash, Timothy P; Mendez-Pertuz, Marinela; Dueñas, Marta; Maietta, Paolo; Martinelli, Paola; Muñoz-Martin, Maribel; Martínez-Fernández, Mónica; Cañamero, Marta; Roncador, Giovanna; Martinez-Torrecuadrada, Jorge L; Grivas, Dimitrios; de la Pompa, Jose Luis; Valencia, Alfonso; Paramio, Jesús M; Real, Francisco X; Serrano, Manuel

    2015-02-01

    NOTCH signaling suppresses tumor growth and proliferation in several types of stratified epithelia. Here, we show that missense mutations in NOTCH1 and NOTCH2 found in human bladder cancers result in loss of function. In murine models, genetic ablation of the NOTCH pathway accelerated bladder tumorigenesis and promoted the formation of squamous cell carcinomas, with areas of mesenchymal features. Using bladder cancer cells, we determined that the NOTCH pathway stabilizes the epithelial phenotype through its effector HES1 and, consequently, loss of NOTCH activity favors the process of epithelial-mesenchymal transition. Evaluation of human bladder cancer samples revealed that tumors with low levels of HES1 present mesenchymal features and are more aggressive. Together, our results indicate that NOTCH serves as a tumor suppressor in the bladder and that loss of this pathway promotes mesenchymal and invasive features.

  6. Vocational Qualifications and Progression to Higher Education: The Case of the 14-19 Diplomas in the English System

    Science.gov (United States)

    Hodgson, Ann; Spours, Ken

    2010-01-01

    Ensuring effective progression from vocational qualifications to higher education has become an important issue internationally as a part of government strategies to raise skill levels and to provide more equitable access to tertiary level study. From September 2008, the Government in England has begun to introduce a new set of qualifications for…

  7. Advising and Progress in the Community College STEM Transfer Pathway

    Science.gov (United States)

    Packard, Becky Wai-Ling; Jeffers, Kimberly C.

    2013-01-01

    Community college students enrolled in science and technology fields face many challenges as they pursue transfer pathways to earn a 4-year degree. Despite clear links to student persistence, advising interactions that facilitate or inhibit transfer progress are not clearly understood. In this study, 82 community college students pursuing science…

  8. Metabolic pathways as possible therapeutic targets for progressive multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Rebecca M Heidker

    2017-01-01

    Full Text Available Unlike relapsing remitting multiple sclerosis, there are very few therapeutic options for patients with progressive forms of multiple sclerosis. While immune mechanisms are key participants in the pathogenesis of relapsing remitting multiple sclerosis, the mechanisms underlying the development of progressive multiple sclerosis are less well understood. Putative mechanisms behind progressive multiple sclerosis have been put forth: insufficient energy production via mitochondrial dysfunction, activated microglia, iron accumulation, oxidative stress, activated astrocytes, Wallerian degeneration, apoptosis, etc. Furthermore, repair processes such as remyelination are incomplete. Experimental therapies that strive to improve metabolism within neurons and glia, e.g., oligodendrocytes, could act to counter inadequate energy supplies and/or support remyelination. Most experimental approaches have been examined as standalone interventions; however, it is apparent that the biochemical steps being targeted are part of larger pathways, which are further intertwined with other metabolic pathways. Thus, the potential benefits of a tested intervention, or of an established therapy, e.g., ocrelizumab, could be undermined by constraints on upstream and/or downstream steps. If correct, then this argues for a more comprehensive, multifaceted approach to therapy. Here we review experimental approaches to support neuronal and glial metabolism, and/or promote remyelination, which may have potential to lessen or delay progressive multiple sclerosis.

  9. Post-Secondary Vocational Education and Training: Pathways and Partnerships. Institutional Management in Higher Education

    Science.gov (United States)

    OECD Publishing (NJ3), 2012

    2012-01-01

    Rapid growth of tertiary education is partly due to the expansion of post-secondary vocational education and training (PSV). A well developed post-secondary PSV system and links between universities and VET institutions improve skills and employment opportunities. What is post-secondary PSV and how does it relate to other components of the…

  10. Developing a Progressive Control Pathway for African Animal Trypanosomosis.

    Science.gov (United States)

    Diall, Oumar; Cecchi, Giuliano; Wanda, Gift; Argilés-Herrero, Rafael; Vreysen, Marc J B; Cattoli, Giovanni; Viljoen, Gerrit J; Mattioli, Raffaele; Bouyer, Jérémy

    2017-07-01

    Progressive control pathways (PCPs) are stepwise approaches for the reduction, elimination, and eradication of human and animal diseases. They provide systematic frameworks for planning and evaluating interventions. Here we outline a PCP for tsetse-transmitted animal trypanosomosis, the scourge of poor livestock keepers in tropical Africa. Initial PCP stages focus on the establishment of national coordination structures, engagement of stakeholders, development of technical capacities, data collection and management, and pilot field interventions. The intermediate stage aims at a sustainable and economically profitable reduction of disease burden, while higher stages target elimination. The mixed-record of success and failure in past efforts against African animal trypanosomosis (AAT) makes the development of this PCP a high priority. Copyright © 2017 Food and Agriculture Organization of the United Nations. Published by Elsevier Ltd.. All rights reserved.

  11. Genetic Variation in Dopamine Pathways Differentially Associated with Smoking Progression in Adolescence

    Science.gov (United States)

    Laucht, Manfred; Becker, Katja; Frank, Josef; Schmidt, Martin H.; Esser, Gunter; Treutlein, Jens; Skowronek, Markus H.; Schumann, Gunter

    2008-01-01

    A study examines whether genetic variation in dopamine pathways differentially associate with smoking progression in adolescence. Results indicate the influence of specific dopamine genes in different stages of smoking progression in adolescents.

  12. Genetic Variation in Dopamine Pathways Differentially Associated with Smoking Progression in Adolescence

    Science.gov (United States)

    Laucht, Manfred; Becker, Katja; Frank, Josef; Schmidt, Martin H.; Esser, Gunter; Treutlein, Jens; Skowronek, Markus H.; Schumann, Gunter

    2008-01-01

    A study examines whether genetic variation in dopamine pathways differentially associate with smoking progression in adolescence. Results indicate the influence of specific dopamine genes in different stages of smoking progression in adolescents.

  13. Learning Pathways between and within Vocational and Higher Education: Towards a Typology?

    Science.gov (United States)

    Harris, Roger; Rainey, Linda

    2012-01-01

    Promotion by governments of the provision of pathways for learners and the principle of seamlessness in post-compulsory education over the past decade may be perceived as both positive and problematic. Seamlessness can provide considerable choice and yet can readily lead to uncertainty and indecision. A number of studies have drawn attention to…

  14. Reconstructing the temporal progression of HIV-1 immune response pathways

    Science.gov (United States)

    Jain, Siddhartha; Arrais, Joel; Venkatachari, Narasimhan J.; Ayyavoo, Velpandi; Bar-Joseph, Ziv

    2016-01-01

    Motivation: Most methods for reconstructing response networks from high throughput data generate static models which cannot distinguish between early and late response stages. Results: We present TimePath, a new method that integrates time series and static datasets to reconstruct dynamic models of host response to stimulus. TimePath uses an Integer Programming formulation to select a subset of pathways that, together, explain the observed dynamic responses. Applying TimePath to study human response to HIV-1 led to accurate reconstruction of several known regulatory and signaling pathways and to novel mechanistic insights. We experimentally validated several of TimePaths’ predictions highlighting the usefulness of temporal models. Availability and Implementation: Data, Supplementary text and the TimePath software are available from http://sb.cs.cmu.edu/timepath Contact: zivbj@cs.cmu.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:27307624

  15. Effects of testosterone on pelvic autonomic pathways: progress and pitfalls.

    Science.gov (United States)

    Keast, J R

    2000-03-15

    Testosterone has potent effects on reproductive behavior, many of which are due to actions on brain nuclei and spinal motoneurons controlling perineal muscles. The autonomic circuits involved in penile erection, ejaculation and emission, have been less commonly considered as targets for circulating androgens. This review demonstrates that many components of pelvic autonomic reflex pathways, including preganglionic neurons, autonomic ganglion cells and primary afferent neurons, are likely to be influenced by testosterone. The steroid appears to play an important role in maintaining neuronal morphology, transmitter synthesis and receptor expression throughout adulthood. Surprisingly, the effects of testosterone are not limited to neurons involved in reproductive reflexes. The challenge is now to determine the range of neuronal features influenced by androgens, and the mechanisms by which these occur. Studies of androgen receptor location indicate that in many autonomic neurons gene expression may be directly influenced by androgens, but a mismatch between receptor distribution and androgen action shows that in some cells other mechanisms must exist. It is also possible that androgens are metabolised to estrogens by some peripheral neurons. Irrespective of the mechanism, it is time to acknowledge that testosterone is an important "maintenance factor" for autonomic neurons.

  16. CD39/adenosine pathway is involved in AIDS progression.

    Directory of Open Access Journals (Sweden)

    Maria Nikolova

    2011-07-01

    Full Text Available HIV-1 infection is characterized by a chronic activation of the immune system and suppressed function of T lymphocytes. Regulatory CD4+ CD25(high FoxP3+CD127(low T cells (Treg play a key role in both conditions. Here, we show that HIV-1 positive patients have a significant increase of Treg-associated expression of CD39/ENTPD1, an ectoenzyme which in concert with CD73 generates adenosine. We show in vitro that the CD39/adenosine axis is involved in Treg suppression in HIV infection. Treg inhibitory effects are relieved by CD39 down modulation and are reproduced by an adenosine-agonist in accordance with a higher expression of the adenosine A2A receptor on patients' T cells. Notably, the expansion of the Treg CD39+ correlates with the level of immune activation and lower CD4+ counts in HIV-1 infected patients. Finally, in a genetic association study performed in three different cohorts, we identified a CD39 gene polymorphism that was associated with down-modulated CD39 expression and a slower progression to AIDS.

  17. Effect of PKC pathway on G1/S progression control in HeLa cells

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The effect of PKC activity on G1/S progression in HeLa cells has been studied.The result shows that (ⅰ) PKC activity alteration in G1 phase affects G1/S progression in HeLa cells.It has been observed that G1/S progression is stimulated by PKC agonist TPA and inhibited by PKC inhibitor GF-109203X.(ⅱ) The expression of c-myc and c-jun is stimulated by TPA and inhibited by GF-109203X treatment in early G1 phase.(ⅲ) During G1/S progression,the expression of CyclinD1 is stimulated by TPA treatment and inhibited by GF-109203X treatment.There is no effect on the expression of CDK4.It is likely that PKC pathway regulates G1/S progression through regulating the expression of some early response genes and engine molecules in HeLa cells.

  18. ILO's Work in Vocational Training

    Science.gov (United States)

    Educational Documentation and Information, 1971

    1971-01-01

    The work of the Vocational Training Branch of the Human Relations Department, International Labour Office (Unesco), is described. The essential purpose is to develop improved practices in vocational training, with a view to progressive establishment of standards at the international level. (JB)

  19. Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer

    OpenAIRE

    2013-01-01

    Pancreatic ductal adenocarcinoma (PDA) remains a lethal human malignancy with historically limited success in treatment. The role of aberrant Notch signaling, which requires the constitutive activation of γ-secretase, in the initiation and progression of PDA is well defined and inhibitors of this pathway are currently in clinical trials. Here we investigated the in vivo therapeutic effect of PF-03084014, a selective γ-secretase inhibitor, alone and in combination with gemcitabine in pancreati...

  20. The role of the collicular pathway in the salience-based progression of visual attention.

    Science.gov (United States)

    Mizzi, Raphaël; Michael, George A

    2014-08-15

    Visual attention has been shown to progress from the most to the least salient item in a given scene. Cognitive and physiological models assume that this orienting of covert attention relies on the collicular pathway, involving the superior colliculus and the pulvinar. Recent studies questioned this statement as they described attentional capture by visual items invisible to the superior colliculus. Electrophysiological studies shown that there is no direct projections from short-wave receptors to the superior colliculus. S-cone stimuli can thus be employed to assess visual processing without the involvement of the collicular pathway. We have attempted to investigate whether this pathway is involved in the salience-based orientation of attention by presenting S-cone stimuli. Volunteers were asked to make a judgment regarding a target among two distractors (all items of unequal sizes). Items' location and size varied randomly, as well as color, randomly black or calibrated for each subject to activate exclusively S-cones. The hierarchical pattern testifying of the salience-based orientation of attention was only found with black stimuli, arguing in favor of an implication of the collicular pathway in salience. In a second experiment, one item was presented at a time in order to test the item-multiplicity effect by comparing experiments. Performance was the most penalized when presenting multiple stimuli in the black condition. Results were interpreted in terms of distinct modes of processing by the collicular and geniculate pathways. The establishment of salience that determines attentional progression appeared to be only possible when the collicular pathway was solicited.

  1. Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progression

    Directory of Open Access Journals (Sweden)

    Mansukhani Mahesh

    2006-05-01

    Full Text Available Abstract Background Cervical Cancer (CC exhibits highly complex genomic alterations. These include hemizygous deletions at 4p15.3, 10q24, 5q35, 3p12.3, and 11q24, the chromosomal sites of Slit-Robo pathway genes. However, no candidate tumor suppressor genes at these regions have been identified so far. Slit family of secreted proteins modulates chemokine-induced cell migration of distinct somatic cell types. Slit genes mediate their effect by binding to its receptor Roundabout (Robo. These genes have shown to be inactivated by promoter hypermethylation in a number of human cancers. Results To test whether Slit-Robo pathway genes are targets of inactivation at these sites of deletion, we examined promoter hypermethylation of SLIT1, SLIT2, SLIT3, ROBO1, and ROBO3 genes in invasive CC and its precursor lesions. We identified a high frequency of promoter hypermethylation in all the Slit-Robo genes resulting in down regulated gene expression in invasive CC, but the inhibitors of DNA methylation and histone deacetylases (HDACs in CC cell lines failed to effectively reactivate the down-regulated expression. These results suggest a complex mechanism of inactivation in the Slit-Robo pathway in CC. By analysis of cervical precancerous lesions, we further show that promoter hypermethylation of Slit-Robo pathway occurs early in tumor progression. Conclusion Taken together, these findings suggest that epigenetic alterations of Slit-Robo pathway genes (i play a role in CC development, (ii further delineation of molecular basis of promoter methylation-mediated gene regulation provides a potential basis for epigenetic-based therapy in advanced stage CC, and (iii form epigenetic signatures to identify precancerous lesions at risk to progression.

  2. The Dutch vocational education and training system

    NARCIS (Netherlands)

    Verhagen, A.M.C.

    2014-01-01

    The Dutch educational system is highly stratified from secondary education onwards3, and this also applies to MBO. Each MBO course can be followed in two different learning pathways, called the vocationally educating learning pathway (beroepsopleidende leerweg: BOL) and the vocationally guiding lear

  3. Understanding the Roles of the Kynurenine Pathway in Multiple Sclerosis Progression

    Directory of Open Access Journals (Sweden)

    Chai K. Lim

    2010-08-01

    Full Text Available The kynurenine pathway (KP is a major degradative pathway of tryptophan ultimately leading to the production of nicotinamide adenine dinucleotide (NAD+ and is also one of the major regulatory mechanisms of the immune response. The KP is known to be involved in several neuroinflammatory disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, AIDS dementia complex, Parkinson’s disease, schizophrenia, Huntington’s disease and brain tumours. However, the KP remains a relatively new topic for the field of multiple sclerosis (MS. Over the last 2–3 years, some evidence has progressively emerged suggesting that the KP is likely to be involved in the pathogenesis of autoimmune diseases especially MS. Some KP modulators are already in clinical trials for other inflammatory diseases and would potentially provide a new and important therapeutic strategy for MS patients. This review summarizes the known relationships between the KP and MS.

  4. Overexpression of protein O-fucosyltransferase 1 accelerates hepatocellular carcinoma progression via the Notch signaling pathway

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Lijie [Liver Surgery Department, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai (China); Dong, Pingping [Department of Gastroenterology and Hepatology, Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai (China); Liu, Longzi; Gao, Qiang; Duan, Meng [Liver Surgery Department, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai (China); Zhang, Si; Chen, She [Key Laboratory of Glycoconjugate Research Ministry of Public Health, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai (China); Xue, Ruyi, E-mail: xue.ruyi@zs-hospital.sh.cn [Department of Gastroenterology and Hepatology, Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai (China); Wang, Xiaoying, E-mail: xiaoyingwang@fudan.edu.cn [Liver Surgery Department, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai (China)

    2016-04-29

    Aberrant activation of Notch signaling frequently occurs in liver cancer, and is associated with liver malignancies. However, the mechanisms regulating pathologic Notch activation in hepatocellular carcinoma (HCC) remain unclear. Protein O-fucosyltransferase 1 (Pofut1) catalyzes the addition of O-linked fucose to the epidermal growth factor-like repeats of Notch. In the present study, we detected the expression of Pofut1 in 8 HCC cell lines and 253 human HCC tissues. We reported that Pofut1 was overexpressed in HCC cell lines and clinical HCC tissues, and Pofut1 overexpression clinically correlated with the unfavorable survival and high disease recurrence in HCC. The in vitro assay demonstrated that Pofut1 overexpression accelerated the cell proliferation and migration in HCC cells. Furthermore, Pofut1 overexpression promoted the binding of Notch ligand Dll1 to Notch receptor, and hence activated Notch signaling pathway in HCC cells, indicating that Pofut1 overexpression could be a reason for the aberrant activation of Notch signaling in HCC. Taken together, our findings indicated that an aberrant activated Pofut1-Notch pathway was involved in HCC progression, and blockage of this pathway could be a promising strategy for the therapy of HCC. - Highlights: • Pofut1 overexpression in HCC was correlated with aggressive tumor behaviors. • Pofut1 overexpression in HCC was associated with poor prognosis. • Pofut1 promoted cell proliferation, migration and invasion in hepatoma cells. • Pofut1 activated Notch signaling pathway in hepatoma cells.

  5. NDRG1 overexpression promotes the progression of esophageal squamous cell carcinoma through modulating Wnt signaling pathway

    Science.gov (United States)

    Ai, Runna; Sun, Yulin; Guo, Zhimin; Wei, Wei; Zhou, Lanping; Liu, Fang; Hendricks, Denver T.; Xu, Yang; Zhao, Xiaohang

    2016-01-01

    ABSTRACT N-myc down-regulated gene 1 (NDRG1) has been shown to regulate tumor growth and metastasis in various malignant tumors and also to be dysregulated in esophageal squamous cell carcinoma (ESCC). Here, we show that NDRG1 overexpression (91.9%, 79/86) in ESCC tumor tissues is associated with poor overall survival of esophageal cancer patients. When placed in stable transfectants of the KYSE 30 ESCC cell line generated by lentiviral transduction with the ectopic overexpression of NDRG1, the expression of transducin-like enhancer of Split 2 (TLE2) was decreased sharply, however β−catenin was increased. Mechanistically, NDRG1 physically associates with TLE2 and β−catenin to affect the Wnt pathway. RNA interference and TLE2 overexpression studies demonstrate that NDRG1 fails to active Wnt pathway compared with isogenic wild-type controls. Strikingly, NDRG1 overexpression induces the epithelial mesenchymal transition (EMT) through activating the Wnt signaling pathway in ESCC cells, decreased the expression of E-cadherin and enhanced the expression of Snail. Our study elucidates a mechanism of NDRG1-regulated Wnt pathway activation and EMT via affecting TLE2 and  β-catenin expression in esophageal cancer cells. This indicates a pro-oncogenic role for NDRG1 in esophageal cancer cells whereby it modulates tumor progression. PMID:27414086

  6. Histologically benign, clinically aggressive: Progressive non-optic pathway pilocytic astrocytomas in adults with NF1.

    Science.gov (United States)

    Strowd, Roy E; Rodriguez, Fausto J; McLendon, Roger E; Vredenburgh, James J; Chance, Aaron B; Jallo, George; Olivi, Alessandro; Ahn, Edward S; Blakeley, Jaishri O

    2016-06-01

    Although optic pathway gliomas are the most common brain tumors associated with neurofibromatosis type 1 (NF1), extra-optic gliomas occur and may behave more aggressively with outcomes that differ by age. A retrospective case-control study was designed to describe the clinical course of adult NF1 patients with progressive extra-optic pilocytic astrocytomas (PAs) and compare to a pediatric cohort. Data for patients treated at the Johns Hopkins Comprehensive Neurofibromatosis Center from 2003 to 2013 were reviewed to identify cases (adults, age >18) and controls (pediatric, age NF1 cases and four pediatric NF1 controls were identified. Mean age was 32.3 ± 9.5 years, 66% male (cases); 12.8 ± 4.2 years, 100% male (controls). Symptomatic progression occurred in two-of-three adults (67%) while the majority of pediatric patients presented with isolated radiographic progression (n = 3, 75%). Onset tended to be more rapid in adults (4 ± 1 vs. 14 ± 8.3 months, P = 0.10). Subtotal resection was the treatment for all pediatric patients. Radiotherapy (n = 2), chemotherapy (n = 2), and targeted, biologic agents (n = 2) were administered in adults. Although all pediatric patients are living, outcomes were universally poor in adults with progression to death in all (median survival 17.1 months, range 6.6-30.3). In conclusion, despite grade I histology, all three adult NF1 patients with progressive extra-optic PAs suffered an aggressive clinical course which was not seen in pediatric patients. Clinicians should be aware of this clinico-histologic discrepancy when counseling and managing adult NF1 patients with progressive extra-optic PAs. © 2016 Wiley Periodicals, Inc.

  7. The role of APE/Ref-1 signaling pathway in hepatocellular carcinoma progression.

    Science.gov (United States)

    Yang, Zhen; Yang, Sun; Misner, Bobbye J; Liu-Smith, Feng; Meyskens, Frank L

    2014-11-01

    Hepatocellular carcinoma (HCC) is responsible for a third of the estimated cancer-caused deaths worldwide. To deeply understand the mechanisms controlling HCC progression is of primary importance to develop new approaches for treatment. Apurinic/apyrimidinic endonuclease-1/redox effector factor 1 (APE/Ref-1) has been uncovered elevated in various types of cancer, including HCC. Additionally, HCC progression is always correlated with elevated copper (Cu). Our previous data demonstrated that Cu treatment initiated APE/Ref-1 expression and its downstream targets. Therefore, we hypothesized that APE/Ref-1 may be involved in HCC progression through mediating the effect of Cu to its signaling cascades. Following different treatments, human HCC cell line (Hep3B) and immortalized non-malignant hepatocyte cell line (THLE3) were analyzed to explore the role of APE/Ref-1 signaling pathway. Unstained human tissue microarrays (TMA) were subjected to IHC analysis to study the relationship between APE/Ref-1 expression and clinic features. APE/Ref-1 was upregulated in HCC cells consistent with the strong expression of APE/Ref-1 in HCC tissue microarray. Greater cytoplasmic accumulation of APE/Ref-1 was found in poorly differentiated and more aggressive tumors. Also we provide evidence to show that APE/Ref-1 signaling pathway stimulates cellular proliferation, enhances anti-apoptosis, and facilitates metastasis through experimental knockdown of APE/Ref-1 using siRNA in Hep3B cells or overexpressing APE/Ref-1 in THLE3 cells. These results define a novel role of APE/Ref-1 in HCC progression as being an important mediating and potentiating molecule, and also provide a basis for further investigations utilizing appropriate APE/Ref-1 inhibitors in combination with chemo-drugs for HCC treatment.

  8. Genomically amplified Akt3 activates DNA repair pathway and promotes glioma progression.

    Science.gov (United States)

    Turner, Kristen M; Sun, Youting; Ji, Ping; Granberg, Kirsi J; Bernard, Brady; Hu, Limei; Cogdell, David E; Zhou, Xinhui; Yli-Harja, Olli; Nykter, Matti; Shmulevich, Ilya; Yung, W K Alfred; Fuller, Gregory N; Zhang, Wei

    2015-03-17

    Akt is a robust oncogene that plays key roles in the development and progression of many cancers, including glioma. We evaluated the differential propensities of the Akt isoforms toward progression in the well-characterized RCAS/Ntv-a mouse model of PDGFB-driven low grade glioma. A constitutively active myristoylated form of Akt1 did not induce high-grade glioma (HGG). In stark contrast, Akt2 and Akt3 showed strong progression potential with 78% and 97% of tumors diagnosed as HGG, respectively. We further revealed that significant variations in polarity and hydropathy values among the Akt isoforms in both the pleckstrin homology domain (P domain) and regulatory domain (R domain) were critical in mediating glioma progression. Gene expression profiles from representative Akt-derived tumors indicated dominant and distinct roles for Akt3, consisting primarily of DNA repair pathways. TCGA data from human GBM closely reflected the DNA repair function, as Akt3 was significantly correlated with a 76-gene signature DNA repair panel. Consistently, compared with Akt1 and Akt2 overexpression models, Akt3-expressing human GBM cells had enhanced activation of DNA repair proteins, leading to increased DNA repair and subsequent resistance to radiation and temozolomide. Given the wide range of Akt3-amplified cancers, Akt3 may represent a key resistance factor.

  9. Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression

    Directory of Open Access Journals (Sweden)

    Stephen A. Rosenberg

    2015-02-01

    Full Text Available Our group has previously reported that the majority of human melanomas (>60% express the metabotropic glutamate receptor 1 (GRM1 and that the glutamate release inhibitor riluzole, a drug currently used to treat amyotrophic lateral sclerosis, can induce apoptosis in GRM1-expressing melanoma cells. Our group previously reported that in vitro riluzole treatment reduces cell growth in three-dimensional (3D soft agar colony assays by 80% in cells with wildtype phosphoinositide 3-kinase (PI3K pathway activation. However, melanoma cell lines harboring constitutive activating mutations of the PI3K pathway (PTEN and NRAS mutations showed only a 35% to 40% decrease in colony formation in soft agar in the presence of riluzole. In this study, we have continued our preclinical studies of riluzole and its effect on melanoma cells alone and in combination with inhibitors of the PI3 kinase pathway: the AKT inhibitor, API-2, and the mammalian target of rapamycin (mTOR inhibitor, rapamycin. We modeled these combinatorial therapies on various melanoma cell lines in 3D and 2D systems and in vivo. Riluzole combined with mTOR inhibition is more effective at halting melanoma anchorage-independent growth and xenograft tumor progression than either agent alone. PI3K signaling changes associated with this combinatorial treatment shows that 3D (nanoculture modeling of cell signaling more closely resembles in vivo signaling than monolayer models. Riluzole combined with mTOR inhibition is effective at halting tumor cell progression independent of BRAF mutational status. This makes this combinatorial therapy a potentially viable alternative for metastatic melanoma patients who are BRAF WT and are therefore ineligible for vemurafenib therapy.

  10. Cholesterol Enhances Colorectal Cancer Progression via ROS Elevation and MAPK Signaling Pathway Activation

    Directory of Open Access Journals (Sweden)

    Caihua Wang

    2017-06-01

    Full Text Available Background/Aims: Elevated serum cholesterol levels were linked to a higher risk of colorectal adenoma and colorectal cancer (CRC, while the effect of cholesterol on CRC metastasis has not been widely studied. Methods: CRC patients were enrolled to evaluate the association between low-density lipoprotein cholesterol (LDL and CRC metastases, and LDL receptor (LDLR level of the CRC tissue was assessed by immunohistochemistry. The effects of LDL on cell proliferation, migration and stemness were assessed in CRC cells in vitro, and the effects of high fat diet (HFD on tumor growth and intestinal tumorigenicity were investigated in vivo. ROS assays, gene expression array analysis and western blot were used to explore the mechanisms of LDL in CRC progression. Results: The level of LDL was positively correlated with liver metastases, and a higher level of LDL receptor (LDLR expression was associated with advanced N and M stages of CRC. In vitro, LDL promoted the migration and sphere formation of CRC cells and induced upregulated expression of “stemness” genes including Sox2, Oct4, Nanog and Bmi 1. High-fat diet (HFD significantly enhanced tumor growth in vivo, and was associated with a shorter intestinal length in azoxymethane/dextran sodium sulfate (AOM/DSS-treated mice. Furthermore, LDL significantly elevated reactive oxygen species (ROS levels and Whole Human Genome Microarray found 87 differentially expressed genes between LDL-treated CRC cells and controls, which were largely clustered in the MAP kinase (MAPK signaling pathway. Conclusions: LDL enhances intestinal inflammation and CRC progression via activation of ROS and signaling pathways including the MAPK pathway. Inflammation is strongly associated with cancer initiation, and the role of LDL in intestinal tumorigenicity should be further explored.

  11. Cholesterol Enhances Colorectal Cancer Progression via ROS Elevation and MAPK Signaling Pathway Activation.

    Science.gov (United States)

    Wang, Caihua; Li, Peiwei; Xuan, Junmei; Zhu, Chunpeng; Liu, Jingjing; Shan, Lizhen; Du, Qin; Ren, Yuezhong; Ye, Jun

    2017-01-01

    Elevated serum cholesterol levels were linked to a higher risk of colorectal adenoma and colorectal cancer (CRC), while the effect of cholesterol on CRC metastasis has not been widely studied. CRC patients were enrolled to evaluate the association between low-density lipoprotein cholesterol (LDL) and CRC metastases, and LDL receptor (LDLR) level of the CRC tissue was assessed by immunohistochemistry. The effects of LDL on cell proliferation, migration and stemness were assessed in CRC cells in vitro, and the effects of high fat diet (HFD) on tumor growth and intestinal tumorigenicity were investigated in vivo. ROS assays, gene expression array analysis and western blot were used to explore the mechanisms of LDL in CRC progression. The level of LDL was positively correlated with liver metastases, and a higher level of LDL receptor (LDLR) expression was associated with advanced N and M stages of CRC. In vitro, LDL promoted the migration and sphere formation of CRC cells and induced upregulated expression of "stemness" genes including Sox2, Oct4, Nanog and Bmi 1. High-fat diet (HFD) significantly enhanced tumor growth in vivo, and was associated with a shorter intestinal length in azoxymethane/dextran sodium sulfate (AOM/DSS)-treated mice. Furthermore, LDL significantly elevated reactive oxygen species (ROS) levels and Whole Human Genome Microarray found 87 differentially expressed genes between LDL-treated CRC cells and controls, which were largely clustered in the MAP kinase (MAPK) signaling pathway. LDL enhances intestinal inflammation and CRC progression via activation of ROS and signaling pathways including the MAPK pathway. Inflammation is strongly associated with cancer initiation, and the role of LDL in intestinal tumorigenicity should be further explored. © 2017 The Author(s). Published by S. Karger AG, Basel.

  12. Overexpression of protein O-fucosyltransferase 1 accelerates hepatocellular carcinoma progression via the Notch signaling pathway.

    Science.gov (United States)

    Ma, Lijie; Dong, Pingping; Liu, Longzi; Gao, Qiang; Duan, Meng; Zhang, Si; Chen, She; Xue, Ruyi; Wang, Xiaoying

    2016-04-29

    Aberrant activation of Notch signaling frequently occurs in liver cancer, and is associated with liver malignancies. However, the mechanisms regulating pathologic Notch activation in hepatocellular carcinoma (HCC) remain unclear. Protein O-fucosyltransferase 1 (Pofut1) catalyzes the addition of O-linked fucose to the epidermal growth factor-like repeats of Notch. In the present study, we detected the expression of Pofut1 in 8 HCC cell lines and 253 human HCC tissues. We reported that Pofut1 was overexpressed in HCC cell lines and clinical HCC tissues, and Pofut1 overexpression clinically correlated with the unfavorable survival and high disease recurrence in HCC. The in vitro assay demonstrated that Pofut1 overexpression accelerated the cell proliferation and migration in HCC cells. Furthermore, Pofut1 overexpression promoted the binding of Notch ligand Dll1 to Notch receptor, and hence activated Notch signaling pathway in HCC cells, indicating that Pofut1 overexpression could be a reason for the aberrant activation of Notch signaling in HCC. Taken together, our findings indicated that an aberrant activated Pofut1-Notch pathway was involved in HCC progression, and blockage of this pathway could be a promising strategy for the therapy of HCC.

  13. Gesture discrimination in primary progressive aphasia: the intersection between gesture and language processing pathways.

    Science.gov (United States)

    Nelissen, Natalie; Pazzaglia, Mariella; Vandenbulcke, Mathieu; Sunaert, Stefan; Fannes, Katrien; Dupont, Patrick; Aglioti, Salvatore M; Vandenberghe, Rik

    2010-05-05

    The issue of the relationship between language and gesture processing and the partial overlap of their neural representations is of fundamental importance to neurology, psychology, and social sciences. Patients suffering from primary progressive aphasia, a clinical syndrome characterized by comparatively isolated language deficits, may provide direct evidence for anatomical and functional association between specific language deficits and gesture discrimination deficits. A consecutive series of 16 patients with primary progressive aphasia and 16 matched control subjects participated. Our nonverbal gesture discrimination task consisted of 19 trials. In each trial, participants observed three video clips showing the same gesture performed correctly in one clip and incorrectly in the other two. Subjects had to indicate which of the three versions was correct. Language and gesture production were evaluated by means of conventional tasks. All participants underwent high-resolution structural and diffusion tensor magnetic resonance imaging. Ten of the primary progressive aphasia patients showed a significant deficit on the nonverbal gesture discrimination task. A factor analysis revealed that this deficit clustered with gesture imitation, word and pseudoword repetition, and writing-to-dictation. Individual scores on this cluster correlated with volume in the left anterior inferior parietal cortex extending into the posterior superior temporal gyrus. Probabilistic tractography indicated this region comprised the cortical relay station of the indirect pathway connecting the inferior frontal gyrus and the superior temporal cortex. Thus, the left perisylvian temporoparietal area may underpin verbal imitative behavior, gesture imitation, and gesture discrimination indicative of a partly shared neural substrate for language and gesture resonance.

  14. Vocational Education and Vocational Skills

    DEFF Research Database (Denmark)

    Madsen, Erik Skov

    Abstract: This paper and presentation is based on case studies in China, Mexico and Denmark. The paper identifies challenges posed to production companies by a lack of vocational skills and vocational education. The study is focusing on different types of production systems i.e. on manual, complex......, a framework of skills related to process tasks is developed. The paper and the presentation conclude that much more focus is needed on the development of vocational education and vocational skills in Denmark, the U.K, and in the U.S. and in China for employees to be able to handle future automated...

  15. How Workplace Experiences While at School Affect Career Pathways. A National Vocational Education and Training Research and Evaluation Program Report

    Science.gov (United States)

    Smith, Erica; Green, Annette

    2005-01-01

    This report describes and analyses how the work activities undertaken by students while at school affect their post-school pathways into and between work and study. Increasingly, students are involved with workplaces while still at school. The three major ways in which this is happening (in order of extent of engagement) are through work…

  16. NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway.

    Science.gov (United States)

    Lei, Jin-Ju; Peng, Rou-Jun; Kuang, Bo-Hua; Yuan, Zhong-Yu; Qin, Tao; Liu, Wen-Sheng; Guo, Yun-Miao; Han, Hui-Qiong; Lian, Yi-Fan; Deng, Cheng-Cheng; Zhang, Hao-Jiong; Chen, Li-Zhen; Feng, Qi-Sheng; Xu, Miao; Feng, Lin; Bei, Jin-Xin; Zeng, Yi-Xin

    2015-09-22

    NOP14, which is functionally conserved among eukaryotes, has been implicated in cancer development. Here, we show that NOP14 is poorly expressed in breast cancer cells and invasive breast cancer tissues. In vivo and in vitro studies indicated that NOP14 suppressed the tumorigenesis and metastasis of breast cancer cells. Further investigations revealed that NOP14 enhanced ERα expression and inhibited the Wnt/β-catenin pathway by up-regulating NRIP1 expression. Survival analysis indicated that low NOP14 expression was significantly associated with poor overall survival (P = 0.0006) and disease-free survival (P = 0.0007), suggesting that NOP14 is a potential prognostic factor in breast cancer. Taken together, our findings reveal that NOP14 may suppress breast cancer progression and provide new insights into the development of targeted therapeutic agents for breast cancer.

  17. A Single Dopamine Pathway Underlies Progressive Locomotor Deficits in a Drosophila Model of Parkinson Disease

    Directory of Open Access Journals (Sweden)

    Thomas Riemensperger

    2013-11-01

    Full Text Available Expression of the human Parkinson-disease-associated protein α-synuclein in all Drosophila neurons induces progressive locomotor deficits. Here, we identify a group of 15 dopaminergic neurons per hemisphere in the anterior medial region of the brain whose disruption correlates with climbing impairments in this model. These neurons selectively innervate the horizontal β and β′ lobes of the mushroom bodies, and their connections to the Kenyon cells are markedly reduced when they express α-synuclein. Using selective mushroom body drivers, we show that blocking or overstimulating neuronal activity in the β′ lobe, but not the β or γ lobes, significantly inhibits negative geotaxis behavior. This suggests that modulation of the mushroom body β′ lobes by this dopaminergic pathway is specifically required for an efficient control of startle-induced locomotion in flies.

  18. Tissue microarray methodology identifies complement pathway activation and dysregulation in progressive multiple sclerosis.

    Science.gov (United States)

    Loveless, Sam; Neal, James W; Howell, Owain W; Harding, Katharine E; Sarkies, Patrick; Evans, Rhian; Bevan, Ryan J; Hakobyan, Svetlana; Harris, Claire L; Robertson, Neil P; Morgan, Bryan Paul

    2017-07-14

    The complement pathway has potential contributions to both white (WM) and grey matter (GM) pathology in Multiple Sclerosis (MS). A quantitative assessment of complement involvement is lacking. Here we describe the use of Tissue MicroArray (TMA) methodology in conjunction with immunohistochemistry to investigate the localization of complement pathway proteins in progressive MS cortical GM and subcortical WM. Antibodies targeting complement proteins C1q, C3b, regulatory proteins C1 inhibitor (C1INH, complement receptor 1 (CR1), clusterin, factor H (FH) and the C5a anaphylatoxin receptor (C5aR) were utilised alongside standard markers of tissue pathology. All stained slides were digitised for quantitative analysis. We found that numbers of cells immunolabelled for HLA-DR, GFAP, C5aR, C1q and C3b were increased in WM lesions (WML) and GM lesions (GML) compared to normal appearing WM (NAWM) and GM (NAGM), respectively. The complement regulators C1INH, CR1, FH and clusterin were more abundant in WM lesions, while the number of C1q+ neurons were increased and the number of C1INH+, clusterin+, FH+ and CR1+ neurons decreased in GM lesions. The number of complement component positive cells (C1q, C3b) correlated with complement regulator expression in WM, but there was no statistical association between complement activation and regulator expression in the GM. We conclude that TMA methodology and quantitative analysis provides evidence of complement dysregulation in MS GML, including an association of the numerical density of C1q+ cells with tissue lesions. Our work confirms that complement activation and dysregulation occur in all cases of progressive MS and suggest that complement may provide potential biomarkers of the disease. © 2017 International Society of Neuropathology.

  19. Notch pathway regulates female germ cell meiosis progression and early oogenesis events in fetal mouse.

    Science.gov (United States)

    Feng, Yan-Min; Liang, Gui-Jin; Pan, Bo; Qin, Xun-Si; Zhang, Xi-Feng; Chen, Chun-Lei; Li, Lan; Cheng, Shun-Feng; De Felici, Massimo; Shen, Wei

    2014-01-01

    A critical process of early oogenesis is the entry of mitotic oogonia into meiosis, a cell cycle switch regulated by a complex gene regulatory network. Although Notch pathway is involved in numerous important aspects of oogenesis in invertebrate species, whether it plays roles in early oogenesis events in mammals is unknown. Therefore, the rationale of the present study was to investigate the roles of Notch signaling in crucial processes of early oogenesis, such as meiosis entry and early oocyte growth. Notch receptors and ligands were localized in mouse embryonic female gonads and 2 Notch inhibitors, namely DAPT and L-685,458, were used to attenuate its signaling in an in vitro culture system of ovarian tissues from 12.5 days post coitum (dpc) fetus. The results demonstrated that the expression of Stra8, a master gene for germ cell meiosis, and its stimulation by retinoic acid (RA) were reduced after suppression of Notch signaling, and the other meiotic genes, Dazl, Dmc1, and Rec8, were abolished or markedly decreased. Furthermore, RNAi of Notch1 also markedly inhibited the expression of Stra8 and SCP3 in cultured female germ cells. The increased methylation status of CpG islands within the Stra8 promoter of the oocytes was observed in the presence of DAPT, indicating that Notch signaling is probably necessary for maintaining the epigenetic state of this gene in a way suitable for RA stimulation. Furthermore, in the presence of Notch inhibitors, progression of oocytes through meiosis I was markedly delayed. At later culture periods, the rate of oocyte growth was decreased, which impaired subsequent primordial follicle assembly in cultured ovarian tissues. Taken together, these results suggested new roles of the Notch signaling pathway in female germ cell meiosis progression and early oogenesis events in mammals.

  20. The Vocational Baccalaureate: A Gateway to Higher Education?

    Science.gov (United States)

    Gendron, Benedicte

    2009-01-01

    Access to the baccalaureate and higher education in France has become more democratic. The introduction of the vocational baccalaureate has been part of this process, but remains a modest step forward given the very low take-up of vocational baccalaureate courses. If vocational education pathways in France are to become true gateways to higher…

  1. Vocational Education and Vocational Skills

    DEFF Research Database (Denmark)

    Madsen, Erik Skov

    Abstract: This paper and presentation is based on case studies in China, Mexico and Denmark. The paper identifies challenges posed to production companies by a lack of vocational skills and vocational education. The study is focusing on different types of production systems i.e. on manual, complex...... and automated production. The paper highlights how both China and Denmark have focused on theoretical rather than vocational education for more than a decade. Based on a combination of a literature review and field studies of cases, including studies of mass production and unmanned and automated production......, a framework of skills related to process tasks is developed. The paper and the presentation conclude that much more focus is needed on the development of vocational education and vocational skills in Denmark, the U.K, and in the U.S. and in China for employees to be able to handle future automated...

  2. Role of the cystathionine γ lyase/hydrogen sulfide pathway in human melanoma progression.

    Science.gov (United States)

    Panza, Elisabetta; De Cicco, Paola; Armogida, Chiara; Scognamiglio, Giosuè; Gigantino, Vincenzo; Botti, Gerardo; Germano, Domenico; Napolitano, Maria; Papapetropoulos, Andreas; Bucci, Mariarosaria; Cirino, Giuseppe; Ianaro, Angela

    2015-01-01

    In humans, two main metabolic enzymes synthesize hydrogen sulfide (H2 S): cystathionine γ lyase (CSE) and cystathionine β synthase (CBS). A third enzyme, 3-mercaptopyruvate sulfurtransferase (3-MST), synthesizes H2 S in the presence of the substrate 3-mercaptopyruvate (3-MP). The immunohistochemistry analysis performed on human melanoma samples demonstrated that CSE expression was highest in primary tumors, decreased in the metastatic lesions and was almost silent in non-lymph node metastases. The primary role played by CSE was confirmed by the finding that the overexpression of CSE induced spontaneous apoptosis of human melanoma cells. The same effect was achieved using different H2 S donors, the most active of which was diallyl trisulfide (DATS). The main pro-apoptotic mechanisms involved were suppression of nuclear factor-κB activity and inhibition of AKT and extracellular signal-regulated kinase pathways. A proof of concept was obtained in vivo using a murine melanoma model. In fact, either l-cysteine, the CSE substrate, or DATS inhibited tumor growth in mice. In conclusion, we have determined that the l-cysteine/CSE/H2 S pathway is involved in melanoma progression.

  3. Contribution of membrane mucins to tumor progression through modulation of cellular growth signaling pathways.

    Science.gov (United States)

    Carraway, Kermit L; Funes, Melanie; Workman, Heather C; Sweeney, Colleen

    2007-01-01

    Mucins are large, heavily O-glycosylated proteins expressed by epithelial tissues. The canonical function of membrane mucins is to provide protection to vulnerable epithelia by forming a steric barrier against assault, and by contributing to the formation of protective extracellular mucin gels. The aberrant overexpression of mucins is thought to contribute to tumor progression by allowing tumor cells to evade immune recognition, and by aiding in the breakdown of cell-cell and cell-matrix contacts to facilitate migration and metastasis. Recent evidence suggests that we should now modify our thinking about mucin function by considering their roles in signaling pathways leading to cellular growth control. Here we review the markedly divergent mechanisms by which membrane mucins, specifically MUC1 and MUC4, influence pathways contributing to cellular proliferation and survival. The cytoplasmic domain of MUC1 serves as a scaffold for the assembly of a variety of signaling proteins, while MUC4 influences the trafficking and localization of growth factor receptors, and hence their responses to external stimuli. We also discuss how tumor cells exploit these mechanisms to promote their own growth and metastasis.

  4. Thiocoraline activates the Notch pathway in carcinoids and reduces tumor progression in vivo.

    Science.gov (United States)

    Wyche, T P; Dammalapati, A; Cho, H; Harrison, A D; Kwon, G S; Chen, H; Bugni, T S; Jaskula-Sztul, R

    2014-12-01

    Carcinoids are slow-growing neuroendocrine tumors (NETs) that are characterized by hormone overproduction; surgery is currently the only option for treatment. Activation of the Notch pathway has previously been shown to have a role in tumor suppression in NETs. The marine-derived thiodepsipeptide thiocoraline was investigated in vitro in two carcinoid cell lines (BON and H727). Carcinoid cells treated with nanomolar concentrations of thiocoraline resulted in a decrease in cell proliferation and an alteration of malignant phenotype evidenced by decrease of NET markers, achaete-scute complex like-1, chromogranin A and neurospecific enolase. Western blotting analysis demonstrated the activation of Notch1 on the protein level in BON cells. Additionally, thiocoraline activated downstream Notch targets HES1, HES5 and HEY2. Thiocoraline effectively suppressed carcinoid cell growth by promoting cell cycle arrest in BON and H727 cells. An in vivo study demonstrated that thiocoraline, formulated with polymeric micelles, slowed carcinoid tumor progression. Thus the therapeutic potential of thiocoraline, which induced activation of the Notch pathway, in carcinoid tumors was demonstrated.

  5. Low Concentration of Caffeine Inhibits the Progression of the Hepatocellular Carcinoma via Akt Signaling Pathway.

    Science.gov (United States)

    Dong, Shuying; Kong, Jian; Kong, Jinge; Shen, Qiang; Kong, Fandong; Sun, Wenbing; Zheng, Lemin

    2015-01-01

    Accumulating evidences have reported that caffeine has anticancer effects at high blood concentrations. However, whether caffeine has anticancer effects on human hepatocellular carcinoma (HCC) cells at low concentration, especially at physiologically applicable concentration (concentrations of caffeine (0, 50, 100, 200, 400 or 600 μM). MTT assay was used to investigate the proliferation ability in vitro. Migration and invasion abilities were determined by wound healing assay and transwell assay. The molecular changes were detected by western blot. An ectopic nude mice model which the mice were gavaged with caffeine was used to reveal the anticancer effects of caffeine on HepG2 cells in vivo. Results showed that caffeine could inhibit the proliferation, migration and invasion significantly at physiologically applicable concentration in vitro. Also the associated molecular changes of cancer progression were observed. In animal experiment, the mice gavaged with caffeine also performanced reduced tumor burden in vivo. Moreover, the interrelated protein expression was also observed in vivo which was coincident with the results in vitro. All in all, this observation indicated that caffeine may suppress the progression of HCC through Akt signaling pathway. This makes caffeine a potential candidate for treating HCC which will be a safer and more effective treatment by giving for a long time at physiologically applicable concentration.

  6. Assessment of Food Chain Pathway Parameters in Biosphere Models: Annual Progress Report for Fiscal Year 2004

    Energy Technology Data Exchange (ETDEWEB)

    Napier, Bruce A.; Krupka, Kenneth M.; Fellows, Robert J.; Cataldo, Dominic A.; Valenta, Michelle M.; Gilmore, Tyler J.

    2004-12-02

    This Annual Progress Report describes the work performed and summarizes some of the key observations to date on the U.S. Nuclear Regulatory Commission’s project Assessment of Food Chain Pathway Parameters in Biosphere Models, which was established to assess and evaluate a number of key parameters used in the food-chain models used in performance assessments of radioactive waste disposal facilities. Section 2 of this report describes activities undertaken to collect samples of soils from three regions of the United States, the Southeast, Northwest, and Southwest, and perform analyses to characterize their physical and chemical properties. Section 3 summarizes information gathered regarding agricultural practices and common and unusual crops grown in each of these three areas. Section 4 describes progress in studying radionuclide uptake in several representative crops from the three soil types in controlled laboratory conditions. Section 5 describes a range of international coordination activities undertaken by Project staff in order to support the underlying data needs of the Project. Section 6 provides a very brief summary of the status of the GENII Version 2 computer program, which is a “client” of the types of data being generated by the Project, and for which the Project will be providing training to the US NRC staff in the coming Fiscal Year. Several appendices provide additional supporting information.

  7. CAV1 promotes HCC cell progression and metastasis through Wnt/β-catenin pathway.

    Directory of Open Access Journals (Sweden)

    Hongxiu Yu

    Full Text Available Caveolin-1 (CAV1 has significant roles in many primary tumors and metastasis, despite the fact that malignant cells from different cancer types have different profiles of CAV1 expression. There is little information concerning CAV1 expression and role in hepatocellular carcinoma (HCC progresion and metastasis. The role of CAV1 in HCC progression was explored in this study. We reported that CAV1 was overexpressed in highly invasive HCC cell lines compared with poorly invasive ones. The immunohistochemical staining was obviously stronger in metastatic HCC samples than in the non-metastatic specimens via tissue microarrays. Furthermore, CAV1 overexpression enhanced HCC cell invasiveness in vitro, and promoted tumorigenicity and lung metastasis in vivo. By contrast, CAV1 stable knockdown markedly reduced these malignant behaviors. Importantly, we found that CAV1 could induce EMT process through Wnt/β-catenin pathway to promote HCC metastasis. We also identify MMP-7 as a novel downstream target of CAV1. We have determined that CAV1 acts as a mediator between hyperactive ERK1/2 signaling and regulation of MMP-7 transcription. Together, these studies mechanistically show a previously unrecognized interplay between CAV1, EMT, ERK1/2 and MMP-7 that is likely significant in the progression of HCC toward metastasis.

  8. AS101 prevents diabetic nephropathy progression and mesangial cell dysfunction: regulation of the AKT downstream pathway.

    Directory of Open Access Journals (Sweden)

    Itay Israel Shemesh

    Full Text Available Diabetic nephropathy (DN is characterized by proliferation of mesangial cells, mesangial expansion, hypertrophy and extracellular matrix accumulation. Previous data have cross-linked PKB (AKT to TGFβ induced matrix modulation. The non-toxic compound AS101 has been previously shown to favorably affect renal pathology in various animal models and inhibits AKT activity in leukemic cells. Here, we studied the pharmacological properties of AS101 against the progression of rat DN and high glucose-induced mesangial dysfunction. In-vivo administration of AS101 to Streptozotocin injected rats didn't decreased blood glucose levels but ameliorated kidney hypotrophy, proteinuria and albuminuria and downregulated cortical kidney phosphorylation of AKT, GSK3β and SMAD3. AS101 treatment of primary rat glomerular mesangial cells treated with high glucose significantly reduced their elevated proliferative ability, as assessed by XTT assay and cell cycle analysis. This reduction was associated with decreased levels of p-AKT, increased levels of PTEN and decreased p-GSK3β and p-FoxO3a expression. Pharmacological inhibition of PI3K, mTORC1 and SMAD3 decreased HG-induced collagen accumulation, while inhibition of GSK3β did not affect its elevated levels. AS101 also prevented HG-induced cell growth correlated to mTOR and (rpS6 de-phosphorylation. Thus, pharmacological inhibition of the AKT downstream pathway by AS101 has clinical potential in alleviating the progression of diabetic nephropathy.

  9. Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression

    Science.gov (United States)

    Lim, Chai K.; Bilgin, Ayse; Lovejoy, David B.; Tan, Vanessa; Bustamante, Sonia; Taylor, Bruce V.; Bessede, Alban; Brew, Bruce J.; Guillemin, Gilles J.

    2017-01-01

    Activation of the kynurenine pathway (KP) of tryptophan metabolism results from chronic inflammation and is known to exacerbate progression of neurodegenerative disease. To gain insights into the links between inflammation, the KP and multiple sclerosis (MS) pathogenesis, we investigated the KP metabolomics profile of MS patients. Most significantly, we found aberrant levels of two key KP metabolites, kynurenic acid (KA) and quinolinic acid (QA). The balance between these metabolites is important as it determines overall excitotoxic activity at the N-methyl-D-Aspartate (NMDA) receptor. We also identified that serum KP metabolic signatures in patients can discriminate clinical MS subtypes with high sensitivity and specificity. A C5.0 Decision Tree classification model discriminated the clinical subtypes of MS with a sensitivity of 91%. After validation in another independent cohort, sensitivity was maintained at 85%. Collectively, our studies suggest that abnormalities in the KP may be associated with the switch from early-mild stage MS to debilitating progressive forms of MS and that analysis of KP metabolites in MS patient serum may have application as MS disease biomarkers. PMID:28155867

  10. New progress in the Reform of the British Vocational Education from the Perspective of the Wolf Report%从 Wolf 报告看英国职业教育改革新进展∗

    Institute of Scientific and Technical Information of China (English)

    李耀辉

    2014-01-01

    2011年3月,英国著名的经济学家、伦敦大学国王学院 Alison Wolf 教授在经过大量调查和访谈的基础上发表了《英国职业教育回顾---Wolf 报告》,在这份近200页的报告中,Wolf 教授对英国现行的职业教育体制进行了深刻的反思,提出了“对英国职业教育彻底的变革”。本文通过对 Wolf报告的文本分析,结合英国新一轮职业教育改革的背景,分析了英国职业教育改革的最新进展,期以对我国职业教育改革有所助益。%In 201 1 March,the famous British economist,Professor Alison Wolf of Kings College, London University published A Review of the British Vocational Education--Wolf Report based on a lot of investigation and interviews.In this nearly 200 - page report,Professor Wolf carries out a profound reflection on the current system of British vocational education,advocates "revolutionary change in Britain vocational education."This paper makes a textual analysis of the Wolf Report,ana-lyses the background and the latest progress in the new round of reform of vocational education in the UK in order to provide inspirations for the vocational education reform in China.

  11. The senescence hypothesis of disease progression in Alzheimer disease: an integrated matrix of disease pathways for FAD and SAD.

    Science.gov (United States)

    Hunter, Sally; Arendt, Thomas; Brayne, Carol

    2013-12-01

    Alzheimer disease (AD) is a progressive, neurodegenerative disease characterised in life by cognitive decline and behavioural symptoms and post-mortem by the neuropathological hallmarks including the microtubule-associated protein tau-reactive tangles and neuritic plaques and amyloid-beta-protein-reactive senile plaques. Greater than 95 % of AD cases are sporadic (SAD) with a late onset and FAD) with an early onset. FAD is associated with various genetic mutations in the amyloid precursor protein (APP) and the presenilins (PS)1 and PS2. As yet, no disease pathway has been fully accepted and there are no treatments that prevent, stop or reverse the cognitive decline associated with AD. Here, we review and integrate available environmental and genetic evidence associated with all forms of AD. We present the senescence hypothesis of AD progression, suggesting that factors associated with AD can be seen as partial stressors within the matrix of signalling pathways that underlie cell survival and function. Senescence pathways are triggered when stressors exceed the cells ability to compensate for them. The APP proteolytic system has many interactions with pathways involved in programmed senescence and APP proteolysis can both respond to and be driven by senescence-associated signalling. Disease pathways associated with sporadic disease may be different to those involving familial genetic mutations. The interpretation we provide strongly points to senescence as an additional underlying causal process in dementia progression in both SAD and FAD via multiple disease pathways.

  12. Mono-2-ethyhexyl phthalate advancing the progression of prostate cancer through activating the hedgehog pathway in LNCaP cells.

    Science.gov (United States)

    Yong, Wang; Jiao, Chen; Jianhui, Wu; Yan, Zhao; Qi, Pan; Xiu, Wang; Zuyue, Sun; Yunhui, Zhang

    2016-04-01

    Hedgehog (Hh) pathway plays a critical role in the progression of prostate cancer (PCa), the most commonly diagnosed non-cutaneous cancer in male adults. Studies showed that di-n-butyl phthalate (DBP) could interference with the Hh pathway. Di-2-ethylhexyl phthalate (DEHP), the congener of DBP, is the major plasticizer used in plastic materials that are inevitably exposed by patients with PCa. The aim of this in vitro study was to investigate whether mono-2-ethyhexyl phthalate (MEHP, the active metabolite of DEHP) could activate the Hh pathway of LNCaP cells. Results showed that the expression of the critical gene of Hh pathway PTCH and androgen-regulated gene KLK3 was significantly decreased on 3, 6 and 9 days with Hh pathway inhibitor cyclopamine's treatment. MEHP notably up-regulated the expression of PTCH with a dose-response relationship in the presence of cyclopamine, which indicate that MEHP might target on the downstream components of Hh pathway and advance the progression of PCa through activating the Hh pathway.

  13. Eicosanoid signalling pathways in the development and progression of colorectal cancer: novel approaches for prevention/intervention.

    Science.gov (United States)

    Cathcart, Mary-Clare; Lysaght, Joanne; Pidgeon, Graham P

    2011-12-01

    Arachidonic acid metabolism through cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P-450 epoxygenase (EPOX) pathways leads to the generation of biologically active eicosanoids, including prostanoids, leukotrienes, hydroxyeicosatetraenoic acid, epoxyeicosatrienoic acid and hydroperoxyeicosatetraenoic acids. Eicosanoid expression levels vary during tumor development and progression of a range of malignancies, including colorectal cancer. The actions of these autocoids are also directly influenced by diet, as demonstrated by recent evidence for omega-3 fatty acids in colorectal cancer (CRC) prevention and/or treatment. Eicosanoids regulate CRC development and progression, while inhibition of these pathways has generally been shown to inhibit tumor growth/progression. A progressive sequence of colorectal cancer development has been identified, ranging from normal colon, to colitis, dysplasia, and carcinoma. While both COX and LOX inhibition are both promising candidates for colorectal cancer prevention and/or treatment, there is an urgent need to understand the mechanisms through which these signalling pathways mediate their effects on tumorigenesis. This will allow identification of safer, more effective strategies for colorectal cancer prevention and/or treatment. In particular, binding to/signalling through prostanoid receptors have recently been the subject of considerable interest in this area. In this review, we discuss the role of the eicosanoid signalling pathways in the development and progression of colorectal cancer. We discuss the effects of the eicosanoids on tumor cell proliferation, their roles in cell death induction, effects on angiogenesis, migration, invasion and their regulation of the immune response. Signal transduction pathways involved in these processes are also discussed. Finally, novel approaches targeting these arachidonic acid-derived eicosanoids (using pharmacological or natural agents) for chemoprevention and/or treatment of

  14. Vocational rehabilitation

    DEFF Research Database (Denmark)

    Labriola, Merete; Thielen, Karsten; Eplov, Lene Falgaard

    2014-01-01

    Work is known to be one of the main sources of human identity. It might be threatened when ill-health impairs individual labour market participation. Vocational rehabilitation, which is based on the bio-psycho-social model of health and function, is the systematic approach to improve employability...... for those who suffer from health-related disabilities. This article gives a short historical overview about vocational rehabilitation in Denmark, describes the current structural and political framework and gives practice examples of local multidisciplinary and intersectoral rehabilitation efforts....

  15. Vocational rehabilitation

    DEFF Research Database (Denmark)

    Labriola, Merete; Thielen, Karsten; Eplov, Lene Falgaard

    2014-01-01

    Work is known to be one of the main sources of human identity. It might be threatened when ill-health impairs individual labour market participation. Vocational rehabilitation, which is based on the bio-psycho-social model of health and function, is the systematic approach to improve employability...... for those who suffer from health-related disabilities. This article gives a short historical overview about vocational rehabilitation in Denmark, describes the current structural and political framework and gives practice examples of local multidisciplinary and intersectoral rehabilitation efforts....

  16. Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis.

    Directory of Open Access Journals (Sweden)

    Jeffrey M Skerker

    2005-10-01

    Full Text Available Two-component signal transduction systems, comprised of histidine kinases and their response regulator substrates, are the predominant means by which bacteria sense and respond to extracellular signals. These systems allow cells to adapt to prevailing conditions by modifying cellular physiology, including initiating programs of gene expression, catalyzing reactions, or modifying protein-protein interactions. These signaling pathways have also been demonstrated to play a role in coordinating bacterial cell cycle progression and development. Here we report a system-level investigation of two-component pathways in the model organism Caulobacter crescentus. First, by a comprehensive deletion analysis we show that at least 39 of the 106 two-component genes are required for cell cycle progression, growth, or morphogenesis. These include nine genes essential for growth or viability of the organism. We then use a systematic biochemical approach, called phosphotransfer profiling, to map the connectivity of histidine kinases and response regulators. Combining these genetic and biochemical approaches, we identify a new, highly conserved essential signaling pathway from the histidine kinase CenK to the response regulator CenR, which plays a critical role in controlling cell envelope biogenesis and structure. Depletion of either cenK or cenR leads to an unusual, severe blebbing of cell envelope material, whereas constitutive activation of the pathway compromises cell envelope integrity, resulting in cell lysis and death. We propose that the CenK-CenR pathway may be a suitable target for new antibiotic development, given previous successes in targeting the bacterial cell wall. Finally, the ability of our in vitro phosphotransfer profiling method to identify signaling pathways that operate in vivo takes advantage of an observation that histidine kinases are endowed with a global kinetic preference for their cognate response regulators. We propose that this

  17. Two-Component Signal Transduction Pathways Regulating Growth and Cell Cycle Progression in a Bacterium: A System-Level Analysis

    Science.gov (United States)

    Skerker, Jeffrey M; Prasol, Melanie S; Perchuk, Barrett S; Biondi, Emanuele G

    2005-01-01

    Two-component signal transduction systems, comprised of histidine kinases and their response regulator substrates, are the predominant means by which bacteria sense and respond to extracellular signals. These systems allow cells to adapt to prevailing conditions by modifying cellular physiology, including initiating programs of gene expression, catalyzing reactions, or modifying protein–protein interactions. These signaling pathways have also been demonstrated to play a role in coordinating bacterial cell cycle progression and development. Here we report a system-level investigation of two-component pathways in the model organism Caulobacter crescentus. First, by a comprehensive deletion analysis we show that at least 39 of the 106 two-component genes are required for cell cycle progression, growth, or morphogenesis. These include nine genes essential for growth or viability of the organism. We then use a systematic biochemical approach, called phosphotransfer profiling, to map the connectivity of histidine kinases and response regulators. Combining these genetic and biochemical approaches, we identify a new, highly conserved essential signaling pathway from the histidine kinase CenK to the response regulator CenR, which plays a critical role in controlling cell envelope biogenesis and structure. Depletion of either cenK or cenR leads to an unusual, severe blebbing of cell envelope material, whereas constitutive activation of the pathway compromises cell envelope integrity, resulting in cell lysis and death. We propose that the CenK–CenR pathway may be a suitable target for new antibiotic development, given previous successes in targeting the bacterial cell wall. Finally, the ability of our in vitro phosphotransfer profiling method to identify signaling pathways that operate in vivo takes advantage of an observation that histidine kinases are endowed with a global kinetic preference for their cognate response regulators. We propose that this system

  18. Weight loss reversed obesity-induced HGF/c-Met pathway and basal-like breast cancer progression

    Directory of Open Access Journals (Sweden)

    Sneha eSundaram

    2014-07-01

    Full Text Available Epidemiologic studies demonstrate that obesity is associated with an aggressive subtype of breast cancer called basal-like breast cancer (BBC. Using the C3(1-TAg murine model of BBC, we previously demonstrated that mice displayed an early onset of tumors when fed obesogenic diets in the adult window of susceptibility. Obesity was also shown to elevate mammary gland expression and activation of hepatocyte growth factor (HGF/c-Met compared to lean controls, a pro-tumorigenic pathway associated with BBC in patients. Epidemiologic studies estimate that weight loss could prevent a large proportion of BBC. We sought to investigate whether weight loss in adulthood prior to tumor onset would protect mice from accelerated tumorigenesis observed in obese mice. Using a life-long model of obesity, C3(1-TAg mice were weaned onto and maintained on an obesogenic high fat diet. Obese mice displayed significant elevations in tumor progression, but not latency or burden. Tumor progression was significantly reversed when obese mice were induced to lose weight by switching to a control low fat diet prior to tumor onset compared to mice maintained on obesogenic diet. It is likely that other factors regulated tumor progression, hence we investigated the HGF/c-Met pathway known to regulate tumorigenesis. Importantly, HGF/c-Met expression in normal mammary glands and c-Met in tumors was elevated with obesity and was significantly reversed with weight loss. Changes in tumor growth could not be explained by measures of HGF action including phospho-AKT or phospho-S6. Other mediators associated with oncogenesis such as hyperinsulinemia and a high leptin/adiponectin ratio were elevated by obesity and reduced with weight loss. In sum, weight loss significantly blunted the obesity-responsive pro-tumorigenic HGF/c-Met pathway and improved several metabolic risk factors associated with BBC, which together may have contributed to the dramatic reversal of obesity-driven tumor

  19. Research progress of SDF-1/CXCR-4 pathway in mesenchymal stem cell homing after myocardial infarction

    Directory of Open Access Journals (Sweden)

    Qiang MA

    2016-06-01

    Full Text Available Mesenchymal stem cells (MSCs, for their potential of differentiation into cardiomyocytes and easy acquisition, have been used in repair of myocardium tissue and improvement of heart functions after myocardial infarction. However, a vexed problem is the low homing rate of MSCs no matter what delivery methods (including intravenous, intracoronary or endocardial delivery are used. SDF-1/CXCR-4 signal pathway plays an important role in variety of stem cell homing, and has been employed to enhance the function of SDF-1/CXCR-4 signal pathway for improving the efficiency of stem cell homing. The present paper has reviewed the methods used recent years to enhance the function of SDF-1/CXCR-4 signal pathway and the mechanism of the signal pathway in MSCs homing. DOI: 10.11855/j.issn.0577-7402.2016.05.14

  20. Functional protein pathway activation mapping of the progression of normal skin to squamous cell carcinoma.

    Science.gov (United States)

    Einspahr, Janine G; Calvert, Valerie; Alberts, David S; Curiel-Lewandrowski, Clara; Warneke, James; Krouse, Robert; Stratton, Steven P; Liotta, Lance; Longo, Caterina; Pellacani, Giovanni; Pellicani, Giovanni; Prasad, Anil; Sagerman, Paul; Bermudez, Yira; Deng, Jianghong; Bowden, G Timothy; Petricoin, Emanuel F

    2012-03-01

    Reverse phase protein microarray analysis was used to identify cell signaling derangements in squamous cell carcinoma (SCC) compared with actinic keratosis (AK) and upper inner arm (UIA). We analyzed two independent tissue sets with isolation and enrichment of epithelial cells by laser capture microdissection. Set 1 served as a pilot and a means to identify protein pathway activation alterations that could be further validated in a second independent set. Set 1 was comprised of 4 AK, 13 SCC, and 20 UIA. Set 2 included 15 AK, 9 SCCs, and 20 UIAs. Activation of 51 signaling proteins, known to be involved in tumorigenesis, were assessed for set 1 and showed that the MEK-ERK [mitogen-activated protein (MAP)/extracellular signal-regulated (ERK; MEK)] pathway was activated in SCC compared with AK and UIA, and that epidermal growth factor receptor (EGFR) and mTOR pathways were aberrantly activated in SCC. Unsupervised two-way hierarchical clustering revealed that AK and UIA shared a common signaling network activation architecture while SCC was dramatically different. Statistical analysis found that prosurvival signaling through phosphorylation of ASK and 4EBP1 as well as increased Bax and Bak expression was higher in AK compared with UIA. We expanded pathway network activation mapping in set 2 to 101 key signaling proteins, which corroborated activation of MEK-ERK, EGFR, and mTOR pathways through discovery of a number of upstream and downstream signaling molecules within these pathways to conclude that SCC is indeed a pathway activation-driven disease. Pathway activation mapping of SCC compared with AK revealed several interconnected networks that could be targeted with drug therapy for potential chemoprevention and therapeutic applications.

  1. More work to do: a pathway for future progress on strengthening nuclear security

    NARCIS (Netherlands)

    Herbach, J.; Pitts-Kiefer, S.

    2015-01-01

    With the nuclear security summit process winding down but much work remaining, it is vital to initiate a process by which states can continue and expand on the substantial progress that already has been made.

  2. Futurism in Vocational Education.

    Science.gov (United States)

    Ediger, Marlow

    Vocational education is likely to change dramatically as society as a whole continues to change in the future. Research conducted by vocational education specialists will likely result in a new scope and sequence of vocational instruction. New theories of vocational education will be developed, as will new instructional methods based on these…

  3. Aberrant DNA methylation of WNT pathway genes in the development and progression of CIMP-negative colorectal cancer.

    Science.gov (United States)

    Galamb, Orsolya; Kalmár, Alexandra; Péterfia, Bálint; Csabai, István; Bodor, András; Ribli, Dezső; Krenács, Tibor; Patai, Árpád V; Wichmann, Barnabás; Barták, Barbara Kinga; Tóth, Kinga; Valcz, Gábor; Spisák, Sándor; Tulassay, Zsolt; Molnár, Béla

    2016-08-02

    The WNT signaling pathway has an essential role in colorectal carcinogenesis and progression, which involves a cascade of genetic and epigenetic changes. We aimed to analyze DNA methylation affecting the WNT pathway genes in colorectal carcinogenesis in promoter and gene body regions using whole methylome analysis in 9 colorectal cancer, 15 adenoma, and 6 normal tumor adjacent tissue (NAT) samples by methyl capture sequencing. Functional methylation was confirmed on 5-aza-2'-deoxycytidine-treated colorectal cancer cell line datasets. In parallel with the DNA methylation analysis, mutations of WNT pathway genes (APC, β-catenin/CTNNB1) were analyzed by 454 sequencing on GS Junior platform. Most differentially methylated CpG sites were localized in gene body regions (95% of WNT pathway genes). In the promoter regions, 33 of the 160 analyzed WNT pathway genes were differentially methylated in colorectal cancer vs. normal, including hypermethylated AXIN2, CHP1, PRICKLE1, SFRP1, SFRP2, SOX17, and hypomethylated CACYBP, CTNNB1, MYC; 44 genes in adenoma vs. NAT; and 41 genes in colorectal cancer vs. adenoma comparisons. Hypermethylation of AXIN2, DKK1, VANGL1, and WNT5A gene promoters was higher, while those of SOX17, PRICKLE1, DAAM2, and MYC was lower in colon carcinoma compared to adenoma. Inverse correlation between expression and methylation was confirmed in 23 genes, including APC, CHP1, PRICKLE1, PSEN1, and SFRP1. Differential methylation affected both canonical and noncanonical WNT pathway genes in colorectal normal-adenoma-carcinoma sequence. Aberrant DNA methylation appears already in adenomas as an early event of colorectal carcinogenesis.

  4. Research on effective teaching methods of higher vocational English

    Institute of Scientific and Technical Information of China (English)

    贺小飞

    2016-01-01

    With the rapid development of our country's education, the progress of English teaching in higher vocational colleges is gradually developed. Effective teaching become an important teaching concept and goal of all school courses. This article, analyzes the present situation of English teaching in higher vocational colleges, and points out that the shortcomings in the process of higher vocational English(HVE) teaching. Finally, attempt to explore some effective strategies to improve the quality of HVE teaching.

  5. The participation of fibroblast growth factor 23 (FGF23)in the progression of osteoporosis via JAK/STAT pathway.

    Science.gov (United States)

    Xu, Lijun; Zhang, Lixia; Zhang, Huijuan; Yang, Zaigang; Qi, Lei; Wang, Yurong; Ren, Shuxin

    2017-08-07

    Osteoporosis (OP) is a major skeletal disorder for the old man. The fibroblast growth factor 23 (FGF23) is a phosphaturic hormone produced by osteoblasts and osteocytes. However, the regulatory mechanisms of FGF23 in the progression of osteoporosis remain poorly understood. This study aims to explore the downstream regulating pathway of FGF23 in postmenopausal osteoporosis. The rat model of osteoporosis was established through ovariectomy (OVX). The investigation demonstrated that the serum levels of FGF23 and the phosphorylation levels of JAK2, STAT1 and STAT3 were up-regulated in the OVX + NVP-BGJ398 group while were down-regulated in the OVX + Anti-FGF23 group than that in the OVX group. Moreover, the JAK2/ STAT1/3 inhibitor, AG490 promoted the OVX-induced increase in the osteocalcin, ALP, BALP, TRAP and CTX-I levels. Besides, AG490 enhanced cartilage lesions and increased TUNEL-positive chondrocytes in the OVX group. In addition, higher protein expression of MMP-1 and MMP-13 and lower expression of COX-II were observed in the OVX + AG490 group than that in the OVX group. Our findings suggested that FGF23 was involved in the progression of osteoporosis via the JAK/STAT signaling pathway. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  6. [Research Progress on Notch Signal Pathway in Acute Graft-Versus-Host Disease -Review].

    Science.gov (United States)

    Guo, Dong-Mei; Li, Ban-Ban; Li, Chun-Pu; Teng, Qing-Liang

    2017-02-01

    The Notch signaling pathway is a highly conserved cell signaling system that plays an essential role in many biological processes. Notch signaling regulates multiple aspects of hematopoiesis, especially during T cell develop-ment. Recent data suggest that Notch also regulates mature T cell differentiation and function. The latest data show that Notch also plays an essential role in alloreactive T cells mediating acute graft-versus-host disease (aGVHD), the most severe complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Notch inhibition in donor-derived T cells or blockade of individual Notch ligands and receptors after transplantation can reduce GVHD severity and mortality in mouse models of allo-HSCT, without causing global immunosuppression. These findings indicate Notch in T cells as an attractive therapeutic target to control aGVHD. In this article, the pathophysiology of aGVHD, the Notch signal pathway and aGVHD are reviewed.

  7. 浅谈高职生人际沟通能力的培养途径%The Pathway to Vocational Students' Interpersonal Communication Skills

    Institute of Scientific and Technical Information of China (English)

    彭华华; 刘喻

    2012-01-01

    Vocational college students form a large group of higher education in China. It's important and urgent to pay enough attention to them and their skills in interpersonal communication. The paper analyzes the current problems of vocational students in interpersonal communication and proposes an appropriate solution to prodive some references on this issue.%高职院校学生是我国高等教育中的一个庞大群体,需要关注他们的成长、成才,尤其是如何处理人际关系问题是摆在当前高职院校教育工作者面前的一个重要而紧迫的任务。文中分析了当前高职生在人际沟通中出现的问题及影响因素,提卅了相应的解决途径,期望对当前高职学生人际沟通能力的培养有所启示。

  8. JAK-STAT pathway in carcinogenesis: Is it relevant to cholangiocarcinoma progression?

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The features of JAK-STAT signaling in liver cells are discussed in the current review. The role of this signaling cascade in carcinogenesis is accentuated. The possible involvement of this pathway and alteration of its elements are compared for normal cholangiocytes,cholangiocarcinoma predisposition and development.Prolactin and interleukin-6 are described in detail as the best studied examples. In addition, the non-classical nuclear translocation of cytokine receptors is discussed in terms of its possible implication to cholangiocarcinoma development.

  9. Does the Vocational Focus of Community Colleges Hinder Students' Educational Attainment?

    Science.gov (United States)

    Roksa, Josipa

    2006-01-01

    This study examines the effects of vocational focus of community colleges on students' educational attainment. By examining different aspects of vocational education and three distinct student outcomes, the results demonstrate variation in the extent to which institutional focus on vocational training influences students' progress through higher…

  10. Epithelial-mesenchymal transition: molecular pathways of hepatitis viruses-induced hepatocellular carcinoma progression.

    Science.gov (United States)

    Panebianco, Concetta; Saracino, Chiara; Pazienza, Valerio

    2014-08-01

    Hepatocellular carcinoma is the fifth most common tumor and the third cause of death for cancer in the world. Among the main causative agents of this tumor is the chronic infection by hepatitis viruses B and C, which establish a context of chronic inflammation degenerating in fibrosis, cirrhosis, and, finally, cancer. Recent findings, however, indicate that hepatitis viruses are not only responsible for cancer onset but also for its progression towards metastasis. Indeed, they are able to promote epithelial-mesenchymal transition, a process of cellular reprogramming underlying tumor spread. In this manuscript, we review the currently known molecular mechanisms by which hepatitis viruses induce epithelial-mesenchymal transition and, thus, hepatocellular carcinoma progression.

  11. Synergistic Action of FOXP3 and TSC1 Pathways During Tumor Progression

    Science.gov (United States)

    2015-10-01

    accumulated mutations may cause the transformation of benign prostatic epithelium to prostatic intraepithelial neoplasia (PIN), with progression to...to invasive carcinoma [1, 2]. However, overexpression of c-Myc or conditional deletion of Pten in mouse prostate epithelium most accurately...the development and function of regulatory T cells [6]. However, FOXP3 is also expressed in epithelial tissues of the breast, lung , and prostate [7

  12. The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression

    Science.gov (United States)

    He, Chunbo; Mao, Dagan; Hua, Guohua; Lv, Xiangmin; Chen, Xingcheng; Angeletti, Peter C; Dong, Jixin; Remmenga, Steven W; Rodabaugh, Kerry J; Zhou, Jin; Lambert, Paul F; Yang, Peixin; Davis, John S; Wang, Cheng

    2015-01-01

    The Hippo signaling pathway controls organ size and tumorigenesis through a kinase cascade that inactivates Yes-associated protein (YAP). Here, we show that YAP plays a central role in controlling the progression of cervical cancer. Our results suggest that YAP expression is associated with a poor prognosis for cervical cancer. TGF-α and amphiregulin (AREG), via EGFR, inhibit the Hippo signaling pathway and activate YAP to induce cervical cancer cell proliferation and migration. Activated YAP allows for up-regulation of TGF-α, AREG, and EGFR, forming a positive signaling loop to drive cervical cancer cell proliferation. HPV E6 protein, a major etiological molecule of cervical cancer, maintains high YAP protein levels in cervical cancer cells by preventing proteasome-dependent YAP degradation to drive cervical cancer cell proliferation. Results from human cervical cancer genomic databases and an accepted transgenic mouse model strongly support the clinical relevance of the discovered feed-forward signaling loop. Our study indicates that combined targeting of the Hippo and the ERBB signaling pathways represents a novel therapeutic strategy for prevention and treatment of cervical cancer. PMID:26417066

  13. Signaling through the PI 3-K, Akt and SGK Pathway in Breast Cancer Progression

    Science.gov (United States)

    2013-12-01

    EGF (R&D Systems; Minneapolis, MN), and 100 ng/ml cholera 120 toxin (List Biological Labs; Campbell, CA); T47D and ZR-75-30 in RPMI 1640 121...Tween 20) containing 5% (w/ v ) non-fat dry milk for 30 min and then incubated with the 216 specific primary antibody diluted in blocking buffer at 4...Kinase AKT pathway in human 519 cancer. Nat. Rev. Cancer. 2002;2:489–501. 520 5. Rodon J, Dienstmann R, Serra V , Tabernero J. Development of PI3K

  14. The Wnt11 Signaling Pathway in Potential Cellular EMT and Osteochondral Differentiation Progression in Nephrolithiasis Formation.

    Science.gov (United States)

    He, Deng; Lu, Yuchao; Hu, Henglong; Zhang, Jiaqiao; Qin, Baolong; Wang, Yufeng; Xing, Shuai; Xi, Qilin; Wang, Shaogang

    2015-07-17

    The molecular events leading to nephrolithiasis are extremely complex. Previous studies demonstrated that calcium and transforming growth factor-β1 (TGF-β1) may participate in the pathogenesis of stone formation, but the explicit mechanism has not been defined. Using a self-created genetic hypercalciuric stone-forming (GHS) rat model, we observed that the increased level of serous/uric TGF-β1 and elevated intracellular calcium in primary renal tubular epithelial cells (PRECs) was associated with nephrolithiasis progression in vivo. In the setting of high calcium plus high TGF-β1 in vitro, PRECs showed great potential epithelial to mesenchymal transition (EMT) progression and osteochondral differentiation properties, representing the multifarious increased mesenchymal and osteochondral phenotypes (Zeb1, Snail1, Col2A1, OPN, Sox9, Runx2) and decreased epithelial phenotypes (E-cadherin, CK19) bythe detection of mRNAs and corresponding proteins. Moreover, TGF-β-dependent Wnt11 knockdown and L-type Ca2+ channel blocker could greatly reverse EMT progression and osteochondral differentiation in PRECs. TGF-β1 alone could effectively promote EMT, but it had no effect on osteochondral differentiation in NRK cells (Rat kidney epithelial cell line). Stimulation with Ca2+ alone did not accelerate differentiation of NRK. Co-incubation of extracellular Ca2+ and TGF-β1 synergistically promotes EMT and osteochondral differentiation in NRK control cells. Our data supplied a novel view that the pathogenesis of calcium stone development may be associated with synergic effects of TGF-β1 and Ca2+, which promote EMT and osteochondral differentiation via Wnt11 and the L-type calcium channel.

  15. The Wnt11 Signaling Pathway in Potential Cellular EMT and Osteochondral Differentiation Progression in Nephrolithiasis Formation

    Directory of Open Access Journals (Sweden)

    Deng He

    2015-07-01

    Full Text Available The molecular events leading to nephrolithiasis are extremely complex. Previous studies demonstrated that calcium and transforming growth factor-β1 (TGF-β1 may participate in the pathogenesis of stone formation, but the explicit mechanism has not been defined. Using a self-created genetic hypercalciuric stone-forming (GHS rat model, we observed that the increased level of serous/uric TGF-β1 and elevated intracellular calcium in primary renal tubular epithelial cells (PRECs was associated with nephrolithiasis progression in vivo. In the setting of high calcium plus high TGF-β1 in vitro, PRECs showed great potential epithelial to mesenchymal transition (EMT progression and osteochondral differentiation properties, representing the multifarious increased mesenchymal and osteochondral phenotypes (Zeb1, Snail1, Col2A1, OPN, Sox9, Runx2 and decreased epithelial phenotypes (E-cadherin, CK19 bythe detection of mRNAs and corresponding proteins. Moreover, TGF-β-dependent Wnt11 knockdown and L-type Ca2+ channel blocker could greatly reverse EMT progression and osteochondral differentiation in PRECs. TGF-β1 alone could effectively promote EMT, but it had no effect on osteochondral differentiation in NRK cells (Rat kidney epithelial cell line. Stimulation with Ca2+ alone did not accelerate differentiation of NRK. Co-incubation of extracellular Ca2+ and TGF-β1 synergistically promotes EMT and osteochondral differentiation in NRK control cells. Our data supplied a novel view that the pathogenesis of calcium stone development may be associated with synergic effects of TGF-β1 and Ca2+, which promote EMT and osteochondral differentiation via Wnt11 and the L-type calcium channel.

  16. Involvement of Autophagic Pathway in the Progression of Retinal Degeneration in a Mouse Model of Diabetes.

    Science.gov (United States)

    Piano, Ilaria; Novelli, Elena; Della Santina, Luca; Strettoi, Enrica; Cervetto, Luigi; Gargini, Claudia

    2016-01-01

    The notion that diabetic retinopathy (DR) is essentially a micro-vascular disease has been recently challenged by studies reporting that vascular changes are preceded by signs of damage and loss of retinal neurons. As to the mode by which neuronal death occurs, the evidence that apoptosis is the main cause of neuronal loss is far from compelling. The objective of this study was to investigate these controversies in a mouse model of streptozotocin (STZ) induced diabetes. Starting from 8 weeks after diabetes induction there was loss of rod but not of cone photoreceptors, together with reduced thickness of the outer and inner synaptic layers. Correspondingly, rhodopsin expression was downregulated and the scotopic electroretinogram (ERG) is suppressed. In contrast, cone opsin expression and photopic ERG response were not affected. Suppression of the scotopic ERG preceded morphological changes as well as any detectable sign of vascular alteration. Only sparse apoptotic figures were detected by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and glia was not activated. The physiological autophagy flow was altered instead, as seen by increased LC3 immunostaining at the level of outer plexiform layer (OPL) and upregulation of the autophagic proteins Beclin-1 and Atg5. Collectively, our results show that the streptozotocin induced DR in mouse initiates with a functional loss of the rod visual pathway. The pathogenic pathways leading to cell death develop with the initial dysregulation of autophagy well before the appearance of signs of vascular damage and without strong involvement of apoptosis.

  17. Genetic analysis of photoreceptor action pathways in Arabidopsis thaliana. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    1991-12-31

    The specific strategies and long-term goals of this proposal remain intact relative to the original proposal. We continue to isolate and characterize photomorphogenic mutants of Arabidopsis thaliana. The molecular and biochemical characterization of one of these mutants, det1, has led to one publication of original data and to one Society for Experimental Biology Symposium paper (see below). The phenotype of a second mutant, det2, has also been studied during this funding period. In addition, we have continued work on a general strategy to isolate mutations in trans-acting regulatory factors that mediate light-regulated gene expression, and have identified several potentially interesting regulatory mutants. In the third funding period, we will concentrate on the genetical, biochemical, and molecular characterization of these new mutants. Construction of double mutants between the new mutants and the previously characterized morphological mutants should allow us to construct a pathway for light-regulated seedling development in Arabidopsis.

  18. [Cinema and professional vocation].

    Science.gov (United States)

    García Sánchez, José Elías

    2011-01-01

    Commercial cinema is both narrative art and a widely-used mass medium that is built upon human stories. Among the contents of these stories there are many vocational aspects. Taking advantage of these circumstances we will proceed to analyze health vocations through eight films. Patch Adams allows us to approach the fulfillment of vocation, which has not been an easy task for women, as we can see in Allá en el setenta y tantos. Vocational fulfillment is at the core of the plot in The Citadel. Something the Lord Made is a good example to illustrate an unfulfilled vocation, in the same way as Awakenings and Arrowsmith represent the fulfillment of an unexpected vocation and a long pursued one. Finally, vocation can demand great sacrifices, which is made crystal clear in Korczak, and when vocation is not strictly followed it might lead to the greatest abominations, which is the case in "The Fugitive. "

  19. Laboratory capacity for diagnosis of foot-and-mouth disease in Eastern Africa: implications for the progressive control pathway

    DEFF Research Database (Denmark)

    Namatovu, Alice; Wekesa, Sabenzia Nabalayo; Tjørnehøj, Kirsten

    2013-01-01

    Background: Accurate diagnosis is pertinent to any disease control programme. If Eastern Africa is to work towards control of foot-and-mouth disease (FMD) using the Progressive Control Pathway for FMD (PCP-FMD) as a tool, then the capacity of national reference laboratories (NRLs) mandated...... to diagnose FMD should match this task. This study assessed the laboratory capacity of 14 NRLs of the Eastern Africa Region Laboratory Network member countries using a semi-structured questionnaire and retrospective data from the World Reference Laboratory for FMD annual reports and Genbank (R) through...... National Centre for Biotechnology Information for the period 2006-2010. Results: The questionnaire response rate was 13/14 (93%). Twelve out of the 13 countries/regions had experienced at least one outbreak in the relevant five year period. Only two countries (Ethiopia and Kenya) had laboratories...

  20. Targeting midkine and pleiotrophin signalling pathways in addiction and neurodegenerative disorders: recent progress and perspectives.

    Science.gov (United States)

    Herradón, G; Pérez-García, C

    2014-02-01

    Midkine (MK) and pleiotrophin (PTN) are two neurotrophic factors that are highly up-regulated in different brain regions after the administration of various drugs of abuse and in degenerative areas of the brain. A deficiency in both MK and PTN has been suggested to be an important genetic factor, which confers vulnerability to the development of the neurodegenerative disorders associated with drugs of abuse in humans. In this review, evidence demonstrating that MK and PTN limit the rewarding effects of drugs of abuse and, potentially, prevent drug relapse is compiled. There is also convincing evidence that MK and PTN have neuroprotective effects against the neurotoxicity and development of neurodegenerative disorders induced by drugs of abuse. Exogenous administration of MK and/or PTN into the CNS by means of non-invasive methods is proposed as a novel therapeutic strategy for addictive and neurodegenerative diseases. Identification of new molecular targets downstream of the MK and PTN signalling pathways or pharmacological modulation of those already known may also provide a more traditional, but probably effective, therapeutic strategy for treating addictive and neurodegenerative disorders. This article is part of a themed section on Midkine. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue-4. © 2013 The British Pharmacological Society.

  1. HnRNP-L mediates bladder cancer progression by inhibiting apoptotic signaling and enhancing MAPK signaling pathways.

    Science.gov (United States)

    Lv, Daojun; Wu, Huayan; Xing, Rongwei; Shu, Fangpeng; Lei, Bin; Lei, Chengyong; Zhou, Xumin; Wan, Bo; Yang, Yu; Zhong, Liren; Mao, Xiangming; Zou, Yaguang

    2017-01-11

    Heterogeneous nuclear ribonucleoprotein L (hnRNP-L) is a promoter of various kinds of cancers, but its actions in bladder cancer (BC) are unclear. In this study, we investigated the function and the underlying mechanism of hnRNP-L in bladder carcinogenesis. Our results demonstrated that enhanced hnRNP-L expression in BC tissues was associated with poor overall survival of BC patients. Depletion of hnRNP-L significantly suppressed cell proliferation in vitro and inhibited xenograft tumor growth in vivo. Furthermore, downregulation of hnRNP-L resulted in G1-phase cell cycle arrest and enhanced apoptosis accompanied by inhibition of EMT and cell migration. All these cellular changes were reversed by ectopic expression of hnRNP-L. Deletion of hnRNP-L resulted in decreased expression of Bcl-2, enhanced expression of caspases-3, -6 and -9 and inhibition of the MAPK signaling pathway. These findings demonstrate that hnRNP-L contributes to poor prognosis and tumor progression of BC by inhibiting the intrinsic apoptotic signaling and enhancing MAPK signaling pathways.

  2. The Analysis on Emotional Education in Vocational School English Teaching

    Institute of Scientific and Technical Information of China (English)

    兰州职业技术学院 730070

    2015-01-01

    In the time of advancing quality education, emotion education has been paid more and more attention. English teaching is both language teaching progress and emotional communication progress. Therefore, emotional education is extremely important and indispensable in vocational school classroom teaching. However, the current application of vocational school emotional education in English classroom teaching is still relatively weak. Based on the theory of emotional education, this paper attempts to explore the methods and strategies of applying emotional education in vocational school English classroom teaching. It has important theoretical significance on promoting the comprehensive development of the vocational school students, improving English teaching effect, promoting the healthy and sustainable development of the vocational school education, and enriching and developing the emotional teaching psychology and cognitive psychology theory.

  3. Comparative analysis of meiotic progression in female mice bearing mutations in genes of the DNA mismatch repair pathway.

    Science.gov (United States)

    Kan, Rui; Sun, Xianfei; Kolas, Nadine K; Avdievich, Elena; Kneitz, Burkhard; Edelmann, Winfried; Cohen, Paula E

    2008-03-01

    The DNA mismatch repair (MMR) family functions in a variety of contexts to preserve genome integrity in most eukaryotes. In particular, members of the MMR family are involved in the process of meiotic recombination in germ cells. MMR gene mutations in mice result in meiotic disruption during prophase I, but the extent of this disruption often differs between male and female meiocytes. To address the role of MMR proteins specifically in female meiosis, we explored the progression of oocytes through prophase I and the meiotic divisions in mice harboring deletions in members of the MMR pathway (Mlh1, Mlh3, Exo1, and an ATPase-deficient variant of Mlh1, Mlh1(G67R)). The colocalization of MLH1 and MLH3, key proteins involved in stabilization of nascent crossovers, was dependent on intact heterodimer formation and was highly correlated with the ability of oocytes to progress through to metaphase II. The exception was Exo1(-/-) oocytes, in which normal MLH1/MLH3 localization was observed followed by failure to proceed to metaphase II. All mutant oocytes were able to resume meiosis after dictyate arrest, but they showed a dramatic decline in chiasmata (to less than 25% of normal), accompanied by varied progression through metaphase I. Taken together, these results demonstrate that MMR function is required for the formation and stabilization of crossovers in mammalian oocytes and that, in the absence of a functional MMR system, the failure to maintain chiasmata results in a reduced ability to proceed normally through the first and second meiotic divisions, despite near-normal levels of meiotic resumption after dictyate arrest.

  4. Vocational Education and Vocational Skills in Production

    DEFF Research Database (Denmark)

    Madsen, Erik Skov

    2015-01-01

    Through case studies in China, Mexico and Denmark, this paper identifies challenges posed to production companies by a lack of vocational skills and vocational education. The study includes manual, complex and automated production procedures. The paper highlights how both China and Denmark have...... focused on theoretical rather than vocational education for more than a decade. Based on a combination of a literature review and field studies of cases, including studies of mass production and unmanned and automated production, a framework of skills related to process tasks is developed. The paper...... concludes that much more focus on the development of vocational education and vocational skills is needed in Denmark, the U.K, the U.S. and in China for employees to be equipped to handle future automated and advanced production systems....

  5. Novel levamisole derivative induces extrinsic pathway of apoptosis in cancer cells and inhibits tumor progression in mice.

    Directory of Open Access Journals (Sweden)

    Mahesh Hegde

    Full Text Available BACKGROUND: Levamisole, an imidazo(2,1-bthiazole derivative, has been reported to be a potential antitumor agent. In the present study, we have investigated the mechanism of action of one of the recently identified analogues, 4a (2-benzyl-6-(4'-fluorophenyl-5-thiocyanato-imidazo[2,1-b][1], [3], [4]thiadiazole. MATERIALS AND METHODS: ROS production and expression of various apoptotic proteins were measured following 4a treatment in leukemia cell lines. Tumor animal models were used to evaluate the effect of 4a in comparison with Levamisole on progression of breast adenocarcinoma and survival. Immunohistochemistry and western blotting studies were performed to understand the mechanism of 4a action both ex vivo and in vivo. RESULTS: We have determined the IC(50 value of 4a in many leukemic and breast cancer cell lines and found CEM cells most sensitive (IC(50 5 µM. Results showed that 4a treatment leads to the accumulation of ROS. Western blot analysis showed upregulation of pro-apoptotic proteins t-BID and BAX, upon treatment with 4a. Besides, dose-dependent activation of p53 along with FAS, FAS-L, and cleavage of CASPASE-8 suggest that it induces death receptor mediated apoptotic pathway in CEM cells. More importantly, we observed a reduction in tumor growth and significant increase in survival upon oral administration of 4a (20 mg/kg, six doses in mice. In comparison, 4a was found to be more potent than its parental analogue Levamisole based on both ex vivo and in vivo studies. Further, immunohistochemistry and western blotting studies indicate that 4a treatment led to abrogation of tumor cell proliferation and activation of apoptosis by the extrinsic pathway even in animal models. CONCLUSION: Thus, our results suggest that 4a could be used as a potent chemotherapeutic agent.

  6. Novel Levamisole Derivative Induces Extrinsic Pathway of Apoptosis in Cancer Cells and Inhibits Tumor Progression in Mice

    Science.gov (United States)

    Hegde, Mahesh; Karki, Subhas S.; Thomas, Elizabeth; Kumar, Sujeet; Panjamurthy, Kuppusamy; Ranganatha, Somasagara R.; Rangappa, Kanchugarakoppal S.; Choudhary, Bibha; Raghavan, Sathees C.

    2012-01-01

    Background Levamisole, an imidazo(2,1-b)thiazole derivative, has been reported to be a potential antitumor agent. In the present study, we have investigated the mechanism of action of one of the recently identified analogues, 4a (2-benzyl-6-(4′-fluorophenyl)-5-thiocyanato-imidazo[2,1-b][1], [3], [4]thiadiazole). Materials and Methods ROS production and expression of various apoptotic proteins were measured following 4a treatment in leukemia cell lines. Tumor animal models were used to evaluate the effect of 4a in comparison with Levamisole on progression of breast adenocarcinoma and survival. Immunohistochemistry and western blotting studies were performed to understand the mechanism of 4a action both ex vivo and in vivo. Results We have determined the IC50 value of 4a in many leukemic and breast cancer cell lines and found CEM cells most sensitive (IC50 5 µM). Results showed that 4a treatment leads to the accumulation of ROS. Western blot analysis showed upregulation of pro-apoptotic proteins t-BID and BAX, upon treatment with 4a. Besides, dose-dependent activation of p53 along with FAS, FAS-L, and cleavage of CASPASE-8 suggest that it induces death receptor mediated apoptotic pathway in CEM cells. More importantly, we observed a reduction in tumor growth and significant increase in survival upon oral administration of 4a (20 mg/kg, six doses) in mice. In comparison, 4a was found to be more potent than its parental analogue Levamisole based on both ex vivo and in vivo studies. Further, immunohistochemistry and western blotting studies indicate that 4a treatment led to abrogation of tumor cell proliferation and activation of apoptosis by the extrinsic pathway even in animal models. Conclusion Thus, our results suggest that 4a could be used as a potent chemotherapeutic agent. PMID:22970136

  7. P-REX1 amplification promotes progression of cutaneous melanoma via the PAK1/P38/MMP-2 pathway.

    Science.gov (United States)

    Wang, Jinhua; Hirose, Hajime; Du, Guanhua; Chong, Kelly; Kiyohara, Eiji; Witz, Isaac P; Hoon, Dave S B

    2017-10-28

    P-REX1 (PIP3-dependent Rac exchange factor-1) is a guanine nucleotide exchange factor that activates Rac by catalyzing exchange of GDP for GTP bound to Rac. Aberrant up-regulation of P-REX1 expression has a role in metastasis however, copy number (CN) and function of P-REX1 in cutaneous melanoma are unclear. To explore the role of P-REX1 in melanoma, SNP 6.0 and Exon 1.0 ST microarrays were assessed. There was a higher CN (2.82-fold change) of P-REX1 in melanoma cells than in melanocytes, and P-REX1 expression was significantly correlated with P-REX1 CN. When P-REX1 was knocked down in cells by P-REX1 shRNA, proliferation, colony formation, 3D matrigel growth, and migration/invasiveness were inhibited. Loss of P-REX1 inhibited cell proliferation by inhibiting cyclin D1, blocking cell cycle, and increased cell apoptosis by reducing expression of the protein survivin. Knockdown of P-REX1 expression inhibited cell migration/invasiveness by disrupting P-REX1/RAC1/PAK1/p38/MMP-2 pathway. Assessment of patient tumors and disease outcome demonstrated lower distant metastasis-free survival among AJCC stage I/II/III patients with high P-REX1 expression compared to patients with low P-REX1 expression. These results suggest P-REX1 plays an important role in tumor progression and a potential theranostic target. Copyright © 2017. Published by Elsevier B.V.

  8. Vocational Guidance for Everyone

    Science.gov (United States)

    Holland, John L.

    1974-01-01

    Describes some of the current problems of vocational guidance, summarizes relevant knowledge and theory in the field, and offers some practical plans for a coordinated, theoretically compatible group of vocational programs, services, and experiences for a high school. (Author/JM)

  9. Vocational Counseling Revisited

    Science.gov (United States)

    O'Brien, Charles R.

    1976-01-01

    The author stresses the importance for counselors to articulate a viable and comprehensive approach to vocational counseling to both clients and the larger society. A re-thinking and re-stating of career education concepts can be a first step in applying vocational theory more constructively. (EA)

  10. Vocational Training in Ireland.

    Science.gov (United States)

    Dooney, Roy; Dunne, Paul

    This monograph, one of a series of studies of vocational education in the countries of the European Communities, describes the vocational training system in Ireland. The study was compiled from existing statistics and descriptions, and most figures cited refer to 1984. The report is organized in eight chapters. Chapter 1 covers population,…

  11. Mapping Nursing Pathways

    Directory of Open Access Journals (Sweden)

    Melanie Birks

    2015-09-01

    Full Text Available Articulated education pathways between the vocational education training sector and universities provide opportunities for students wishing to progress to higher qualifications. Enrolled nurses seeking to advance their career in nursing can choose to enter baccalaureate degree programs through such alternative entry routes. Awarding of credit for prior studies is dependent on accurate assessment of the existing qualification against that which is sought. This study employed a modified Delphi method to inform the development of an evidence-based, structured approach to mapping the pathway from the nationally consistent training package of the Diploma of Nursing to the diversity of baccalaureate nursing programs across Australia. The findings of this study reflect the practical nature of the role of the enrolled nurse, particularly the greater emphasis placed on direct care activities as opposed to those related to professional development and the generation and use of evidence. These findings provide a valuable summative overview of the relationship between the Diploma of Nursing and the expectations of the registered nurse role.

  12. Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/β-catenin and Wnt/PCP signaling pathways.

    Science.gov (United States)

    Wang, Chengze; Xu, Xin; Jin, Hairu; Liu, Gangli

    2017-05-01

    To investigate the effects and the possible underlying mechanisms of nicotine stimulation on tongue squamous cell carcinoma (TSCC) progression, a TSCC cell line Cal27 and 34 samples of paraffin-embedded TSCC were examined. Immunofluorescence, western blot analysis, and TOP/FOP flash, CCK-8, wound healing and Transwell invasion assays were used to evaluate Cal27 in response to nicotine stimulation. We also investigated expression levels of related proteins of Wnt/β-catenin and Wnt/PCP pathways in paraffin-embedded TSCC samples with or without a history of smoking by immunohistochemistry. Nicotine stimulation can promote proliferation, migration, and invasion of TSCC cells in vitro, downregulate E-cadherin, and activate the Wnt/β-catenin and Wnt/PCP pathways, which could be antagonized by the α7 nicotine acetylcholine receptor (α7 nAChR) inhibitor α-BTX. Moreover, the expression levels of β-catenin, Wnt5a and Ror2 were higher in TSCC patients with a history of smoking than those without a history of smoking. Our results suggest nicotine may promote tongue squamous carcinoma cells progression by activating the Wnt/β-catenin and Wnt/PCP signaling pathways and may play a significant role in the progression and metastasis of smoking-related TSCC.

  13. Vocations: The Link between Post-Compulsory Education and the Labour Market. What the Research Says For... Industry

    Science.gov (United States)

    Wheelahan, Leesa; Buchanan, John; Yu, Serena

    2015-01-01

    This summary brings together the relevant key findings for industry from the research program "Vocations: The Link between Post-Compulsory Education and the Labour Market." The program was comprised of three different strands: (1) pathways from VET in Schools, (2) pathways within and between vocational education and training (VET) and…

  14. Vocations: The Link between Post-Compulsory Education and the Labour Market. What the Research Says For... Qualification & Approval Bodies

    Science.gov (United States)

    Wheelahan, Leesa; Buchanan, John; Yu, Serena

    2015-01-01

    This summary pulls together the relevant key findings for qualification and approval bodies from the research program "Vocations: The Link between Post-Compulsory Education and the Labour Market." The program was comprised of three different strands: (1) pathways from VET in Schools, (2) pathways within and between vocational education…

  15. Stem cell signaling as a target for novel drug discovery: recent progress in the WNT and Hedgehog pathways

    Institute of Scientific and Technical Information of China (English)

    Songzhu Michael AN; Qiang Peter DING; Ling-song LI

    2013-01-01

    One of the most exciting fields in biomedical research over the past few years is stem cell biology,and therapeutic application of stem cells to replace the diseased or damaged tissues is also an active area in development.Although stem cell therapy has a number of technical challenges and regulatory hurdles to overcome,the use of stem cells as tools in drug discovery supported by mature technologies and established regulatory paths is expected to generate more immediate returns.In particular,the targeting of stem cell signaling pathways is opening up a new avenue for drug discovery.Aberrations in these pathways result in various diseases,including cancer,fibrosis and degenerative diseases.A number of drug targets in stem cell signaling pathways have been identified.Among them,WNT and Hedgehog are two most important signaling pathways,which are the focus of this review.A hedgehog pathway inhibitor,vismodegib (Erivedge),has recently been approved by the US FDA for the treatment of skin cancer,while several drug candidates for the WNT pathway are entering clinical trials.We have discovered that the stem cell signaling pathways respond to traditional Chinese medicines.Substances isolated from herbal medicine may act specifically on components of stem cell signaling pathways with high affinities.As many of these events can be explained through molecular interactions,these phenomena suggest that discovery of stem cell-targeting drugs from natural products may prove to be highly successful.

  16. Developments in Vocational Education since 1976.

    Science.gov (United States)

    Henze, Jurgen

    1984-01-01

    Assesses developments in Chinese vocational education since 1976 and between 1949 and 1976; defines terminology; profiles secondary vocational education alternatives, including secondary specialized schools, workers' training schools, agricultural/vocational high schools, vocational (technical) schools, apprenticeship training, and continuation…

  17. Systematic CpG islands methylation profiling of genes in the wnt pathway in epithelial ovarian cancer identifies biomarkers of progression-free survival.

    Science.gov (United States)

    Dai, Wei; Teodoridis, Jens M; Zeller, Constanze; Graham, Janet; Hersey, Jenny; Flanagan, James M; Stronach, Euan; Millan, David W; Siddiqui, Nadeem; Paul, Jim; Brown, Robert

    2011-06-15

    Wnt pathways control key biological processes that potentially impact on tumor progression and patient survival. We aimed to evaluate DNA methylation at promoter CpG islands (CGI) of Wnt pathway genes in ovarian tumors at presentation and identify biomarkers of patient progression-free survival (PFS). Epithelial ovarian tumors (screening study n = 120, validation study n = 61), prospectively collected through a cohort study, were analyzed by differential methylation hybridization at 302 loci spanning 189 promoter CGIs at 137 genes in Wnt pathways. The association of methylation and PFS was examined by Cox proportional hazards model. DNA methylation is associated with PFS at 20 of 302 loci (P < 0.05, n = 111), with 5 loci significant at false discovery rate (FDR) less than 10%. A total of 11 of 20 loci retain significance in an independent validation cohort (n = 48, P ≤ 0.05, FDR ≤ 10%), and 7 of these loci, at FZD4, DVL1, NFATC3, ROCK1, LRP5, AXIN1, and NKD1 genes, are independent from clinical parameters (adjusted P < 0.05). Increased methylation at these loci associates with increased hazard of disease progression. A multivariate Cox model incorporates only NKD1 and DVL1, identifying two groups differing in PFS [HR = 2.09; 95% CI (1.39-3.15); permutation test P < 0.005]. Methylation at DVL1 and NFATC3 show significant association with response. Consistent with their epigenetic regulation, reduced expression of FZD4, DVL1, and ROCK1 is an indicator of early-disease relapse in an independent ovarian tumor cohort (n = 311, adjusted P < 0.05). The data highlight the importance of epigenetic regulation of multiple promoter CGIs of Wnt pathway genes in ovarian cancer and identify methylation at NKD1 and DVL1 as independent predictors of PFS. ©2011 AACR.

  18. Progress in the unraveling of the endoplasmic reticulum stress/autophagy pathway and cancer: implications for future therapeutic approaches.

    Science.gov (United States)

    Schleicher, Stephen M; Moretti, Luigi; Varki, Vinod; Lu, Bo

    2010-06-01

    Given the inherent resistance to apoptosis that characterizes cancer, the targeting of alternative pathways is an attractive strategy to improve anti-tumor therapy. Endoplasmic reticulum (ER) stress, which is basally activated in many cancers, and the subsequent activation of autophagy represent novel cancer treatment targets. While these associated pathways are often protective and promote cell survival, when excessive, ER stress results in autophagic cell death. Therefore, depending on the circumstances, either inhibition or activation of ER stress and autophagy can improve cancer therapy. This review provides an update on how ER stress relates to autophagy, and how these associated pathways can serve dual functions to promote survival or cell death in cancer. Furthermore, it lays out a spectrum of potential pharmacological agents and combinatorial approaches that target these pathways to enhance tumor cell kill.

  19. The role of EXT and growth signalling pathways in osteochondroma and its progression towards secondary peripheral chondrosarcoma

    NARCIS (Netherlands)

    Hameetman, Liesbeth

    2007-01-01

    Osteochondroma is a cartilage capped benign bone tumour, arising at the external surface of bones preformed by endochondral ossification. A small percentage of osteochondromas can progress towards its malignant counterpart, secondary peripheral chondrosarcoma. About 15% of osteochondromas occur in

  20. Dual model of vocational education: Austrian example

    Directory of Open Access Journals (Sweden)

    Tomić Milica

    2015-01-01

    Full Text Available Dual education, as a form of secondary vocational education means that education and practical training are held on two locations - in school and in a company (organization, factory and that these two institutions jointly participate in the realization of vocational education. The paper presents an account of the functioning of dual education in Austria. In that framework special attention was paid to law regulations in this field, the modes of dual education, progression through the system and the perspectives of the young in the labour market. Among the key features of dual education which are, at the same time, considered the factors of its successfulness, the following stand out: active role of social partners in the conceptualization and realization of vocational education; intensive practical training of high quality; systemic interrelatedness of vocational schools and firms where practical training is provided, the compliance of the offer of educational profiles and the needs of labour market; the system of stimulation for the firms that provide professional training for students, clear legislation and the system of professional qualifications. Yet, the challenges of dual educations are not neglected in the paper.

  1. The dual role of complement in the progression of renal disease in NZB/W F(1) mice and alternative pathway inhibition.

    Science.gov (United States)

    Sekine, Hideharu; Ruiz, Phillip; Gilkeson, Gary S; Tomlinson, Stephen

    2011-10-01

    Complement plays a dual role in the progression of systemic lupus erythematosus since it has important protective functions, such as the clearance of immune complexes and apoptotic cells, but is also a mediator of renal inflammation. To investigate this balance in a clinically relevant setting, we investigated how targeted inhibition of all complement pathways vs. targeted inhibition of only the alternative pathway impacts immune and therapeutic outcomes in NZB/W F(1) mice. Following onset of proteinuria, mice were injected twice weekly with CR2-fH (inhibits alternative pathway), CR2-Crry (inhibits all pathways at C3 activation step), sCR2 (C3d targeting vehicle) or saline. Sera were analyzed every 2 weeks for anti-dsDNA antibody levels, and urinary albumin excretion was determined. Kidneys were collected for histological evaluation at 32 weeks. Compared to the control group, all CR2-fH, CR2-Crry and sCR2 treated groups showed significantly reduced serum anti-dsDNA antibody levels and strong trends towards reduced glomerular IgG deposition levels. Glomerular C3 deposition levels were also significantly reduced in all three-treated groups. However, significant reductions of disease activity (albuminuria and glomerulonephritis) were only seen in the CR2-fH treated group. These data highlight the dual role played by complement in the pathogenesis of lupus, and demonstrate a benefit of selectively inhibiting the alternative complement pathway, presumably because of protective contributions from the classical and/or lectin pathways. The sCR2 targeting moiety appears to be contributing to therapeutic outcome via modulation of autoimmunity. Furthermore, these results are largely consistent with our previous data using the MRL/lpr lupus model, thus broadening the significance of these findings.

  2. Progress in Understanding the Genetic Information and Biosynthetic Pathways behind Amycolatopsis Antibiotics, with Implications for the Continued Discovery of Novel Drugs.

    Science.gov (United States)

    Chen, Su; Wu, Qihao; Shen, Qingqing; Wang, Hong

    2016-01-01

    Species of Amycolatopsis, well recognized as producers of both vancomycin and rifamycin, are also known for producing other secondary metabolites, with wide usage in medicine and agriculture. The molecular genetics of natural antibiotics produced by this genus have been well studied. Since the rise of antibiotic resistance, finding new drugs to fight infection has become an urgent priority. Progress in understanding the biosynthesis of metabolites greatly helps the rational manipulation of biosynthetic pathways, and thus to achieve the goal of generating novel natural antibiotics. The efforts made in exploiting Amycolatopsis genome sequences for the discovery of novel natural products and biosynthetic pathways are summarized. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Research Progress on Milk Protein Synthesis Signal Pathway%乳蛋白合成信号通路的研究进展

    Institute of Scientific and Technical Information of China (English)

    史琳琳; 赵锋; 高学军; 李庆章

    2013-01-01

    This review makes an introduction on the composition of milk protein synthesis about JAK-STAT and PI3K/ AKT-mTOR signal pathways, the roles and the control mechanisms of the milk protein synthesis, also the regulation of hormones on these signal pathways. The research progress related to JAK-STAT and mTOR signal pathways is summarized. The review lays the foundation for grasp integrally and researching deeply of milk protein synthesis signal pathways.%作者综述了乳蛋白合成信号通路JAK-STAT和mTOR的组成、在合成乳蛋白中的作用和机理,以及激素等对乳蛋白合成信号通路的刺激调控,对近年来JAK-STAT和mTOR通路的相关研究进展进行了综述,为乳蛋白合成信号通路的整体性把握和深入研究奠定了基础.

  4. PARENTAL ATTITUDES TOWARDS VOCATIONAL EDUCATION ...

    African Journals Online (AJOL)

    Elizabeth

    This paper looked at one aspect of societal attitudes towards vocational education by conducting a survey ... services in Nigeria. Key Words: Parental Attitude, Vocational Education, Counselling, skill .... Some were 4 scale attitude questions ...

  5. Exogenous hydrogen sulfide exerts proliferation, anti-apoptosis, migration effects and accelerates cell cycle progression in multiple myeloma cells via activating the Akt pathway.

    Science.gov (United States)

    Zheng, Dong; Chen, Ziang; Chen, Jingfu; Zhuang, Xiaomin; Feng, Jianqiang; Li, Juan

    2016-10-01

    Hydrogen sulfide (H2S), regarded as the third gaseous transmitter, mediates and induces various biological effects. The present study investigated the effects of H2S on multiple myeloma cell progression via amplifying the activation of Akt pathway in multiple myeloma cells. The level of H2S produced in multiple myeloma (MM) patients and healthy subjects was measured using enzyme-linked immunosorbent assay (ELISA). MM cells were treated with 500 µmol/l NaHS (a donor of H2S) for 24 h. The expression levels of phosphorylated-Akt (p-Akt), Bcl-2 and caspase-3 were measured by western blot assay. Cell viability was detected by Cell Counting Kit 8 (CCK-8). The cell cycle was analyzed by flow cytometry. Our results show that the concentration of H2S was higher in MM patients and that it increased in parallel with disease progression. Treating MM cells with 500 µmol/l NaHS for 24 h markedly increased the expression level of Bcl-2 and the activation of p-Akt, however, the expression level of caspase-3 was decreased, cell viability was increased, and cell cycle progression was accelerated in MM cells. NaHS also induced migration in MM cells in transwell migration assay. Furthermore, co-treatment of MM cells with 500 µmol/l NaHS and 50 µmol/l LY294002 for 24 h significantly overset these effects. In conclusion, our findings demonstrate that the Akt pathway contributes to NaHS-induced cell proliferation, migration and acceleration of cell cycle progression in MM cells.

  6. Modulation of pentose phosphate pathway during cell cycle progression in human colon adenocarcinoma cell line HT29

    NARCIS (Netherlands)

    P. Vizan; G. Alcarraz-Vizan; S. Diaz-Moralli; O.N. Solovjeva; W.M. Frederiks; M. Cascante

    2009-01-01

    Cell cycle regulation is dependent on multiple cellular and molecular events. Cell proliferation requires metabolic sources for the duplication of DNA and cell size. However, nucleotide reservoirs are not sufficient to support cell duplication and, therefore, bio-synthetic pathways should be upregul

  7. Handbook on Marketing Vocational Education.

    Science.gov (United States)

    Martin, William R.

    Compiled after interviews with vocational educators at urban and rural joint vocational schools, comprehensive high schools, and career centers considered to be successful at marketing vocational education locally in Ohio, this handbook contains information on successful marketing activities that other local educators can undertake. Section I…

  8. Access to Elementary Education in India: Politics, Policies and Progress. CREATE Pathways to Access. Research Monograph No. 44

    Science.gov (United States)

    Little, Angela W.

    2010-01-01

    This monograph examines progress in, and policies for, access to elementary education over the past 60 years, the role played by political factors in the process of policy formulation and implementation and the drivers and inhibitors of the implementation of reforms in elementary education in recent years in India. Drawing on interviews and…

  9. Involvement of hydrogen sulfide and homocysteine transsulfuration pathway in the progression of kidney fibrosis after ureteral obstruction.

    Science.gov (United States)

    Jung, Kyong-Jin; Jang, Hee-Seong; Kim, Jee In; Han, Sang Jun; Park, Jeen-Woo; Park, Kwon Moo

    2013-12-01

    Hydrogen sulfide (H2S) produced by cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) in the transsulfuration pathway of homocysteine plays a number of pathophysiological roles. Hyperhomocysteinemia is involved in kidney fibrosis. However, the role of H2S in kidney fibrosis remains to be defined. Here, we investigated the role of H2S and its acting mechanism in unilateral ureteral obstruction (UO)-induced kidney fibrosis in mice. UO decreased expressions of CBS and CSE in the kidney with decrease of H2S concentration. Treatment with sodium hydrogen sulfide (NaHS, a H2S producer) during UO reduced UO-induced oxidative stress with preservations of catalase, copper-zinc superoxide dismutase (CuZnSOD), and manganese superoxide dismutase (MnSOD) expression, and glutathione level. In addition, NaHS mitigated decreases of CBS and CSE expressions, and H2S concentration in the kidney. NaHS treatment attenuated UO-induced increases in levels of TGF-β1, activated Smad3, and activated NF-κB. This study provided the first evidence of involvement of the transsulfuration pathway and H2S in UO-induced kidney fibrosis, suggesting that H2S and its transsulfuration pathway may be a potential target for development of therapeutics for fibrosis-related diseases.

  10. Proteins in the nutrient-sensing and DNA damage checkpoint pathways cooperate to restrain mitotic progression following DNA damage.

    Directory of Open Access Journals (Sweden)

    Jennifer S Searle

    2011-07-01

    Full Text Available Checkpoint pathways regulate genomic integrity in part by blocking anaphase until all chromosomes have been completely replicated, repaired, and correctly aligned on the spindle. In Saccharomyces cerevisiae, DNA damage and mono-oriented or unattached kinetochores trigger checkpoint pathways that bifurcate to regulate both the metaphase to anaphase transition and mitotic exit. The sensor-associated kinase, Mec1, phosphorylates two downstream kinases, Chk1 and Rad53. Activation of Chk1 and Rad53 prevents anaphase and causes inhibition of the mitotic exit network. We have previously shown that the PKA pathway plays a role in blocking securin and Clb2 destruction following DNA damage. Here we show that the Mec1 DNA damage checkpoint regulates phosphorylation of the regulatory (R subunit of PKA following DNA damage and that the phosphorylated R subunit has a role in restraining mitosis following DNA damage. In addition we found that proteins known to regulate PKA in response to nutrients and stress either by phosphorylation of the R subunit or regulating levels of cAMP are required for the role of PKA in the DNA damage checkpoint. Our data indicate that there is cross-talk between the DNA damage checkpoint and the proteins that integrate nutrient and stress signals to regulate PKA.

  11. Proteins in the Nutrient-Sensing and DNA Damage Checkpoint Pathways Cooperate to Restrain Mitotic Progression following DNA Damage

    Science.gov (United States)

    Searle, Jennifer S.; Wood, Matthew D.; Kaur, Mandeep; Tobin, David V.; Sanchez, Yolanda

    2011-01-01

    Checkpoint pathways regulate genomic integrity in part by blocking anaphase until all chromosomes have been completely replicated, repaired, and correctly aligned on the spindle. In Saccharomyces cerevisiae, DNA damage and mono-oriented or unattached kinetochores trigger checkpoint pathways that bifurcate to regulate both the metaphase to anaphase transition and mitotic exit. The sensor-associated kinase, Mec1, phosphorylates two downstream kinases, Chk1 and Rad53. Activation of Chk1 and Rad53 prevents anaphase and causes inhibition of the mitotic exit network. We have previously shown that the PKA pathway plays a role in blocking securin and Clb2 destruction following DNA damage. Here we show that the Mec1 DNA damage checkpoint regulates phosphorylation of the regulatory (R) subunit of PKA following DNA damage and that the phosphorylated R subunit has a role in restraining mitosis following DNA damage. In addition we found that proteins known to regulate PKA in response to nutrients and stress either by phosphorylation of the R subunit or regulating levels of cAMP are required for the role of PKA in the DNA damage checkpoint. Our data indicate that there is cross-talk between the DNA damage checkpoint and the proteins that integrate nutrient and stress signals to regulate PKA. PMID:21779180

  12. Expression microarray meta-analysis identifies genes associated with Ras/MAPK and related pathways in progression of muscle-invasive bladder transition cell carcinoma.

    Directory of Open Access Journals (Sweden)

    Jonathan A Ewald

    Full Text Available The effective detection and management of muscle-invasive bladder Transition Cell Carcinoma (TCC continues to be an urgent clinical challenge. While some differences of gene expression and function in papillary (Ta, superficial (T1 and muscle-invasive (≥T2 bladder cancers have been investigated, the understanding of mechanisms involved in the progression of bladder tumors remains incomplete. Statistical methods of pathway-enrichment, cluster analysis and text-mining can extract and help interpret functional information about gene expression patterns in large sets of genomic data. The public availability of patient-derived expression microarray data allows open access and analysis of large amounts of clinical data. Using these resources, we investigated gene expression differences associated with tumor progression and muscle-invasive TCC. Gene expression was calculated relative to Ta tumors to assess progression-associated differences, revealing a network of genes related to Ras/MAPK and PI3K signaling pathways with increased expression. Further, we identified genes within this network that are similarly expressed in superficial Ta and T1 stages but altered in muscle-invasive T2 tumors, finding 7 genes (COL3A1, COL5A1, COL11A1, FN1, ErbB3, MAPK10 and CDC25C whose expression patterns in muscle-invasive tumors are consistent in 5 to 7 independent outside microarray studies. Further, we found increased expression of the fibrillar collagen proteins COL3A1 and COL5A1 in muscle-invasive tumor samples and metastatic T24 cells. Our results suggest that increased expression of genes involved in mitogenic signaling may support the progression of muscle-invasive bladder tumors that generally lack activating mutations in these pathways, while expression changes of fibrillar collagens, fibronectin and specific signaling proteins are associated with muscle-invasive disease. These results identify potential biomarkers and targets for TCC treatments, and

  13. Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression

    DEFF Research Database (Denmark)

    Wang, Zhipeng; Jin, Haifeng; Xu, Ruodan

    2009-01-01

    Triptolide, a diterpenoid triepoxide from the traditional Chinese medicinal herb Tripterygium wilfordii Hook. f., is a potential treatment for autoimmune diseases as well a possible anti-tumor agent. It inhibits proliferation of colorectal cancer cells in vitro and in vivo. In this study, its...... ability to block progress of colitis to colon cancer, and its molecular mechanism of action are investigated. A mouse model for colitis-induced colorectal cancer was used to test the effect of triptolide on cancer progression. Treatment of mice with triptolide decreased the incidence of colon cancer...... formation, and increased survival rate. Moreover, triptolide decreased the incidence of tumors in nude mice inoculated with cultured colon cancer cells dose-dependently. In vitro, triptolide inhibited the proliferation, migration and colony formation of colon cancer cells. Secretion of IL6 and levels of JAK...

  14. Ingredients of Huangqi decoction slow biliary fibrosis progression by inhibiting the activation of the transforming growth factor-beta signaling pathway

    Directory of Open Access Journals (Sweden)

    Du Jin-Xing

    2012-04-01

    Full Text Available Abstract Background Huangqi decoction was first described in Prescriptions of the Bureau of Taiping People's Welfare Pharmacy in Song Dynasty (AD 1078, and it is an effective recipe that is usually used to treat consumptive disease, anorexia, and chronic liver diseases. Transforming growth factor beta 1 (TGFβ1 plays a key role in the progression of liver fibrosis, and Huangqi decoction and its ingredients (IHQD markedly ameliorated hepatic fibrotic lesions induced by ligation of the common bile duct (BDL. However, the mechanism of IHQD on hepatic fibrotic lesions is not yet clear. The purpose of the present study is to elucidate the roles of TGFβ1 activation, Smad-signaling pathway, and extracellular signal-regulated kinase (ERK in the pathogenesis of biliary fibrosis progression and the antifibrotic mechanism of IHQD. Methods A liver fibrosis model was induced by ligation of the common bile duct (BDL in rats. Sham-operation was performed in control rats. The BDL rats were randomly divided into two groups: the BDL group and the IHQD group. IHQD was administrated intragastrically for 4 weeks. At the end of the fifth week after BDL, animals were sacrificed for sampling of blood serum and liver tissue. The effect of IHQD on the TGFβ1 signaling pathway was evaluated by western blotting and laser confocal microscopy. Results Decreased content of hepatic hydroxyproline and improved liver function and histopathology were observed in IHQD rats. Hepatocytes, cholangiocytes, and myofibroblasts in the cholestatic liver injury released TGFβ1, and activated TGFβ1 receptors can accelerate liver fibrosis. IHQD markedly inhibited the protein expression of TGFβ1, TGFβ1 receptors, Smad3, and p-ERK1/2 expression with no change of Smad7 expression. Conclusion IHQD exert significant therapeutic effects on BDL-induced fibrosis in rats through inhibition of the activation of TGFβ1-Smad3 and TGFβ1-ERK1/2 signaling pathways.

  15. An Investigation into the Practice in Project-based Teaching through Multiple Pathways for Vocational Marketing Major%高职营销类专业多途径项目化教学的实践探索

    Institute of Scientific and Technical Information of China (English)

    刘卫国

    2016-01-01

    高职院校营销类专业学生培养,应将多途径项目化教学与社会服务实践相融合,综合考虑目标、过程、应用、评估等方面,并与社会服务实践进行融合,最终达成社会服务能力建设、高职院校人才培养目标。%The cultivation of students majored in Marketing in higher vocational colleges shall integrate multi-approach project based teaching with practice in social service,and take the target,process,application,assessment,etc.,into account comprehensively and adapt to social service practice,so as to achieve the goal of the construction of social service ability and the goal of higher vocational education.

  16. N-glycosylation at Asn residues 554 and 566 of E-cadherin affects cell cycle progression through extracellular signal-regulated protein kinase signaling pathway

    Institute of Scientific and Technical Information of China (English)

    Hongbo Zhao; Xiliang Zha; Lidong Sun; Liying Wang; Zhibin Xu; Feng Zhou; Jianmin Su; Jiawei Jin; Yong Yang; Yali Hu

    2008-01-01

    E-cadherin, which has a widely acknowledged role in mediating calcium-dependent cell-cell adhesion between epithelial cells, also functions as a tumor suppressor. The ectodomain of human E-cadherin contains four potential N-glycosylation sites at Asn residues 554, 566, 618, and 633.We investigated the role of E-cadherin N-glycosylation in cell cycle progression by site-directed mutagenesis. We showed previously that all four potential N-glycosylation sites of E-cadherin were N-glycosylated in human breast carcinoma MDA-MB-435 cells. Removal of N-glycan at Asn633 dramatically affected E-cadherin stability. In this study we showed that E-cadherin mutant missing N-glycans at Asn554, Asn566 and Asn618 failed to induce cell cycle arrest in G1 phase and to suppress cell proliferation in comparison with wild-type E-cadherin. Moreover, N-glycans at Asn554 and Asn566, but not at Asn618, seemed to be indispensable for E-cadherin-mediated suppression of cell cycle progression.Removal of N-glycans at either Asn554 or Asn566 of E-cadherin was accompanied with the activation of the extracellular signal-regulated protein kinase signaling pathway. After treatment with PD98059, an inhibitor of the extraceilular signal-regulated protein kinase signaling pathway, wild-type E-cadherin transfected MDA-MB-435 and E-cadherin N-glycosylation-deficient mutant transfected MDA-MB-435 cells had equivalent numbers of cells in G1 phase. These findings implied that N-glycosylation might be crucial for E-cadherin-mediated suppression of cell cycle progression.

  17. Vocational Trajectories within the Australian Labour Market. Research Report

    Science.gov (United States)

    Yu, Serena; Bretherton, Tanya; Schutz, Hanna

    2012-01-01

    This is a report of the first year of a three-year project entitled "Vocations: the link between post-compulsory education and the labour market." The project's aim is to research how pathways can be improved within education, within work, and between education and work. There are three strands in the project; the first strand is…

  18. Dropout in vocational education

    DEFF Research Database (Denmark)

    Jørgensen, Christian Helms

    For the last ten years drop out of vocational education has increased strongly in Denmark. Only half of the students, who take up a vocational programme on upper secondary level, complete it. Like in other European countries the low completion rates has caused considerable alarm on the political...... level (Lamb and Markussen 2011). Continuing high dropout rates will make it very hard for the government to reach its target for educational completion, and the government has launched a series of measures to increase retention including the obligation for all colleges to make plans for retention...

  19. MRI of optic nerve and postchiasmal visual pathways and visual evoked potentials in secondary progressive multiple sclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Davies, M.B.; Hawkins, C.P. [School of Postgraduate Medicine, Keele Univ. (United Kingdom)]|[Department of Neurology and Neurophysiology, Royal Infirmary, Stoke-on-Trent (United Kingdom); Williams, R. [MRI Unit Cornwall House, Stoke-on-Trent (United Kingdom); Haq, N. [Department of Neurology, North Staffordshire Hospital, Stoke-on-Trent (United Kingdom); Pelosi, L. [Department of Neurology and Neurophysiology, Royal Infirmary, Stoke-on-Trent (United Kingdom)

    1998-12-01

    We studied the relationship between abnormalities shown by MRI and functional disturbances in the visual pathway as assessed by the visual evoked potential (VEP) in 25 patients with established multiple sclerosis (MS); only 4 of whom had a history of acute optic neuritis. Optic nerve MRI was abnormal in 19 (76 %) and is thus useful in detecting subclinical disease. Optic nerve total lesion length and area on the STIR sequence was found to correlate significantly with prolongation of the VEP latency. This may reflect a predominantly demyelinating rather than inflammatory origin for the signal change in the optic nerve. (orig.) With 5 figs., 1 tab., 25 refs.

  20. Vocations: The Link between Post-Compulsory Education and the Labour Market. What the Research Says For... Government & Policy-Makers

    Science.gov (United States)

    Wheelahan, Leesa; Buchanan, John; Yu, Serena

    2015-01-01

    This summary brings together the relevant key findings for government and policy-makers from the research program "Vocations: The Link between Post-Compulsory Education and the Labour Market." The program was comprised of three different strands: (1) pathways from VET in Schools, (2) pathways within and between vocational education and…

  1. The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress

    Science.gov (United States)

    Rozpędek, W.; Pytel, D.; Mucha, B.; Leszczyńska, H.; Diehl, J. Alan; Majsterek, I.

    2016-01-01

    Hypoxia is a major hallmark of the tumor microenvironment that is strictly associated with rapid cancer progression and induction of metastasis. Hypoxia inhibits disulfide bond formation and impairs protein folding in the Endoplasmic Reticulum (ER). The stress in the ER induces the activation of Unfolded Protein Response (UPR) pathways via the induction of protein kinase RNA-like endoplasmic reticulum kinase (PERK). As a result, the level of phosphorylated Eukaryotic Initiation Factor 2 alpha (eIF2α) is markedly elevated, resulting in the promotion of a pro-adaptive signaling pathway by the inhibition of global protein synthesis and selective translation of Activating Transcription Factor 4 (ATF4). On the contrary, during conditions of prolonged ER stress, pro-adaptive responses fail and apoptotic cell death ensues. Interestingly, similar to the activity of the mitochondria, the ER may also directly activate the apoptotic pathway through ER stress-mediated leakage of calcium into the cytoplasm that leads to the activation of death effectors. Apoptotic cell death also ensues by ATF4-CHOP- mediated induction of several pro-apoptotic genes and suppression of the synthesis of anti-apoptotic Bcl-2 proteins. Advancing molecular insight into the transition of tumor cells from adaptation to apoptosis under hypoxia-induced ER stress may provide answers on how to overcome the limitations of current anti-tumor therapies. Targeting components of the UPR pathways may provide more effective elimination of tumor cells and as a result, contribute to the development of more promising anti-tumor therapeutic agents. PMID:27211800

  2. The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress.

    Science.gov (United States)

    Rozpedek, W; Pytel, D; Mucha, B; Leszczynska, H; Diehl, J A; Majsterek, I

    2016-01-01

    Hypoxia is a major hallmark of the tumor microenvironment that is strictly associated with rapid cancer progression and induction of metastasis. Hypoxia inhibits disulfide bond formation and impairs protein folding in the Endoplasmic Reticulum (ER). The stress in the ER induces the activation of Unfolded Protein Response (UPR) pathways via the induction of protein kinase RNA-like endoplasmic reticulum kinase (PERK). As a result, the level of phosphorylated Eukaryotic Initiation Factor 2 alpha (eIF2α) is markedly elevated, resulting in the promotion of a pro-adaptive signaling pathway by the inhibition of global protein synthesis and selective translation of Activating Transcription Factor 4 (ATF4). On the contrary, during conditions of prolonged ER stress, pro-adaptive responses fail and apoptotic cell death ensues. Interestingly, similar to the activity of the mitochondria, the ER may also directly activate the apoptotic pathway through ER stress-mediated leakage of calcium into the cytoplasm that leads to the activation of death effectors. Apoptotic cell death also ensues by ATF4-CHOP- mediated induction of several pro-apoptotic genes and suppression of the synthesis of anti-apoptotic Bcl-2 proteins. Advancing molecular insight into the transition of tumor cells from adaptation to apoptosis under hypoxia-induced ER stress may provide answers on how to overcome the limitations of current anti-tumor therapies. Targeting components of the UPR pathways may provide more effective elimination of tumor cells and as a result, contribute to the development of more promising anti-tumor therapeutic agents.

  3. IVA: Improving Vocational Administration.

    Science.gov (United States)

    EPD Consortium D, Richardson, TX.

    These six instructional units are intended to provide instructors of vocational education administration with a systematic package of materials for their programs of preservice and/or inservice instruction and to provide materials which could be reproduced for learner use. These units cover the following subject matter: (1) federal legislation…

  4. Vocational Education and Training.

    Science.gov (United States)

    van Leeuwen, Fred, Ed.

    2000-01-01

    This issue of the quarterly Education International focuses on vocational education and training (VET). The editorial, "Education and the Wealth of Nations" (Fred van Leeuwen), focuses on provision of quality education for all. "Education International's (EI's) First Joint Worldwide Action on Education Issues" (Elie Jouen) describes the Global…

  5. IVA: Improving Vocational Administration.

    Science.gov (United States)

    EPD Consortium D, Richardson, TX.

    These six instructional units are intended to provide instructors of vocational education administration with a systematic package of materials for their programs of preservice and/or inservice instruction and to provide materials which could be reproduced for learner use. These units cover the following subject matter: (1) federal legislation…

  6. Piperine blocks interleukin-2-driven cell cycle progression in CTLL-2 T lymphocytes by inhibiting multiple signal transduction pathways.

    Science.gov (United States)

    Doucette, Carolyn D; Greenshields, Anna L; Liwski, Robert S; Hoskin, David W

    2015-04-02

    Piperine, a pungent alkaloid found in the fruits of black pepper plants, has diverse physiological effects, including the ability to inhibit immune cell-mediated inflammation. Since the cytokine interleukin-2 (IL-2) is essential for the clonal expansion and differentiation of T lymphocytes, we investigated the effect of piperine on IL-2 signaling in IL-2-dependent mouse CTLL-2 T lymphocytes. Tritiated-thymidine incorporation assays and flow cytometric analysis of Oregon Green 488-stained cells showed that piperine inhibited IL-2-driven T lymphocyte proliferation; however, piperine did not cause T lymphocytes to die or decrease their expression of the high affinity IL-2 receptor, as determined by flow cytometry. Western blot analysis showed that piperine blocked the IL-2-induced phosphorylation of signal transducer and activator of transcription (STAT) 3 and STAT5 without affecting the upstream phosphorylation of Janus kinase (JAK) 1 and JAK3. In addition, piperine inhibited the IL-2-induced phosphorylation of extracellular signal-regulated kinase 1/2 and Akt, which are signaling molecules that regulate cell cycle progression. Piperine also suppressed the expression of cyclin-dependent kinase (Cdk) 1, Cdk4, Cdk6, cyclin B, cyclin D2, and Cdc25c protein phosphatase by IL-2-stimulated T lymphocytes, indicating G0/G1 and G2/M cell cycle arrest. Piperine-mediated inhibition of IL-2 signaling and cell cycle progression in CTLL-2 T lymphocytes suggests that piperine should be further investigated in animal models as a possible natural source treatment for T lymphocyte-mediated transplant rejection and autoimmune disease.

  7. Blockage of PI3K/PKB/P27kip1 signaling pathway can antagonize 17β-estradiol-induced Ishikawa proliferation and cell cycle progression

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ It is well-known that risk for endometrial adenocar- cinoma increases in patients with high level of estrogen that is unopposed by progestin. And activation of extracellular signal-regulated kinase (ERK)1 and phosphatidylinositol 3 kinase/protein kinase B (PI3K/PKB) pathway are responsible for hormone-dependent cell growth in endometrial carcinoma.2-4 PI3K produces phosphatidylinositol- 3-phosphates by phosphory- lating the D3 hydroxyl of phosphoinositides, leading to membrane translocation of PKB, on which PKB is phosphorylated and activated. Then the activated PKB can stimulate antiapoptotic cellular responses and block apoptotic functions of the cells, thus regulate the apoptosis and proliferation of cell, cell cycle progression, glucose usage, and angiogenesis.

  8. Canolol inhibits gastric tumors initiation and progression through COX-2/PGE2 pathway in K19-C2mE transgenic mice.

    Directory of Open Access Journals (Sweden)

    Donghui Cao

    Full Text Available 4-Vinyl-2, 6-dimethoxyphenol (canolol is an antioxidant phenolic compound extracted from crude canola oil. In current research, K19-C2mE transgenic mice, developing hyperplastic tumors spontaneously in the glandular stomach, were used to study the mechanisms involved in the anti-inflammation and anti-tumor effects of canolol. Tg mice receiving canolol diet had a reduced tumor incidence, to 41.2%, compared with Non-treatment Tg mice, 77.8% of which had gastric tumor (P=0.002. Besides that, the mean tumor diameter was decreased from 6.5 mm to 4.5 mm (P<0.001 after canolol administration. COX-2/PGE2 pathway is known to play pivotal role in inflammation-induced gastric tumorigenesis. The neutrophils and lymphocytes infiltration was suppressed significantly, and the mRNA levels of the proinflammatory cytokines COX-2, IL-1β and IL-12b were also downregulated in gastric mucosa. Additionally, immunohistochemical analysis showed that COX-2, EP2, Gαs and β-catenin, key factors involving in PGE2 signal transduction, were positive staining with higher H scores in Non-treatment Tg mice, while the expressions were suppressed significantly by 0.1% canolol (P<0.001. In addition, tumor-suppressor miR-7 was reactivated after canolol administration, and COX-2 was showed to be a functional target of miR-7 to suppress the tumor progression. In conclusion, canolol could inhibit the gastritis-related tumor initiation and progression, and the suppression effect was correlated with the blocking up of canonical COX-2/PGE2 signaling pathway and might be regulated by miR-7.

  9. Downregulation of miR-382 by propranolol inhibits the progression of infantile hemangioma via the PTEN-mediated AKT/mTOR pathway.

    Science.gov (United States)

    Li, Dongfan; Li, Peng; Guo, Zhengtuan; Wang, Huaijie; Pan, Weikang

    2017-03-01

    Approximately 10% of infantile hemangiomas (IHs) are the most common vascular tumors affecting children and are characterized by rapid growth, and can have destructive, disfiguring and even life-threatening consequences. Currently, propranolol is considered to be a safe and effective treatment option for problematic proliferating IHs. Recent studies have also revealed that microRNAs (miRNAs or miRs) play important roles in the regulation of angiogenesis. In this study, XPTS‑1 cells were used as a hemangioma-derived endothelial cell line constructed in our laboratory. Through a series of experiments, we discovered that miR‑382 is a novel miRNA associated with IHs, which was overexpressed in XPTS‑1 cells and was conversely downregulated by treatment with propranolol. In addition, we found that miR‑382 contributes to the progression of IHs. Our results revealed that propranolol inhibited XPTS‑1 cell migration and proliferation, and promoted apoptosis, and these effects were reversed by the restoration of miR‑382 expression by transfection of the cells with an miR‑382 overexpression vector. Further experiments revealed that the above-mentioned effects were associated with the phosphatase and tensin homolog (PTEN)-mediated AKT/mammalian target of rapamycin (mTOR) signaling pathway. The expression of PTEN was upregulated, while that of p-AKT, p-mTOR and p-p70S6K was downregulated by propranolol; these effects were partly reversed by the overexpression of miR‑382. On the whole, our study identified that the downregulation of miR‑382 by propranolol inhibits the progression of IHs via the PTEN-mediated AKT/mTOR pathway.

  10. Obesity enhances nongenomic estrogen receptor crosstalk with the PI3K/Akt and MAPK pathways to promote in vitro measures of breast cancer progression.

    Science.gov (United States)

    Bowers, Laura W; Cavazos, David A; Maximo, Ilane X F; Brenner, Andrew J; Hursting, Stephen D; deGraffenried, Linda A

    2013-01-01

    crosstalk between nongenomic ERα signaling and the PI3K/Akt and MAPK pathways. Circulating factors in the serum of obese postmenopausal women stimulate ERα positive breast cancer cell viability and growth by facilitating non-genomic ERα crosstalk with the PI3K/Akt and MAPK signaling pathways. These findings provide valuable insight into one mechanism by which obesity may promote ERα positive postmenopausal breast cancer progression and endocrine therapy resistance.

  11. The Inspiration Given by the Successful Practice of Development of Higher Vocational Education in the Developed Countries

    Science.gov (United States)

    Wu, Gaoling

    2010-01-01

    Higher vocational education is the product of economic development, scientific and technological progress. If the country does not have a well-developed vocational education, it is impossible to make a good advanced science and technology into productive forces, it is also impossible to achieve economy development in a high speed. In turn, powers…

  12. Notch信号通路在神经精神领域的研究进展%Research progress on Notch signaling pathway in neuropsychiatry

    Institute of Scientific and Technical Information of China (English)

    雷蕾; 孙宁; 杜巧荣; 刘志芬; 杨春霞; 张克让

    2015-01-01

    Notch signal pathway is an evolutionarily conservative signal transduction system, which can regularly regulate cell proliferation, apoptosis, differentiation, apoptosis, adhesion, stem cell self-renewal, and organogenesis. In the central nervous system, Notch proteins express not only in embryonic stage, but also persist in the nervous system of adult animals, which can adjust and control the regulation of neural stem cell self-renewal and differentiation. Studies show that Notch signal pathway is closely related to neurological diseases and mental disorders, such as neurodevelopmental defects, cerebral ischemia injury, Alzheimer's disease, depression, schizophrenia, etc. This review introduceed the research progress on Notch signaling pathway in neuropsychiatry.%Notch 信号通路是一条进化上十分保守的信号转导系统,是少数能够反复调节细胞增殖和凋亡的信号转导系统,与细胞的增殖、分化、凋亡、黏附以及干细胞的自我更新有密切的联系。在中枢神经系统,Notch 蛋白不仅在胚胎阶段表达,并且持续存在于成年动物的神经系统中,调控了神经干细胞的自我更新和分化过程。研究显示 Notch 与神经发育缺陷、脑缺血损伤、阿尔茨海默病等神经系统疾病及抑郁症、精神分裂症等精神疾病密切相关。本文拟对 Notch 信号通路在神经精神领域的研究进展作一介绍。

  13. p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways.

    Directory of Open Access Journals (Sweden)

    Karen S Kelly-Spratt

    2004-08-01

    Full Text Available Ectopic expression of oncogenes such as Ras induces expression of p19(Arf, which, in turn, activates p53 and growth arrest. Here, we used a multistage model of squamous cell carcinoma development to investigate the functional interactions between Ras, p19(Arf, and p53 during tumor progression in the mouse. Skin tumors were induced in wild-type, p19(Arf-deficient, and p53-deficient mice using the DMBA/TPA two-step protocol. Activating mutations in Hras were detected in all papillomas and carcinomas examined, regardless of genotype. Relative to wild-type mice, the growth rate of papillomas was greater in p19(Arf-deficient mice, and reduced in p53-deficient mice. Malignant conversion of papillomas to squamous cell carcinomas, as well as metastasis to lymph nodes and lungs, was markedly accelerated in both p19 (Arf- and p53-deficient mice. Thus, p19(Arf inhibits the growth rate of tumors in a p53-independent manner. Through its regulation of p53, p19(Arf also suppresses malignant conversion and metastasis. p53 expression was upregulated in papillomas from wild-type but not p19( Arf-null mice, and p53 mutations were more frequently seen in wild-type than in p19( Arf-null carcinomas. This indicates that selection for p53 mutations is a direct result of signaling from the initiating oncogenic lesion, Hras, acting through p19(Arf.

  14. Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression

    Directory of Open Access Journals (Sweden)

    Muhammad Tariq Saeed

    2016-09-01

    Full Text Available The alteration of glucose metabolism, through increased uptake of glucose and glutamine addiction, is essential to cancer cell growth and invasion. Increased flux of glucose through the Hexosamine Biosynthetic Pathway (HBP drives increased cellular O-GlcNAcylation (hyper-O-GlcNAcylation and contributes to cancer progression by regulating key oncogenes. However, the association between hyper-O-GlcNAcylation and activation of these oncogenes remains poorly characterized. Here, we implement a qualitative modeling framework to analyze the role of the Biological Regulatory Network in HBP activation and its potential effects on key oncogenes. Experimental observations are encoded in a temporal language format and model checking is applied to infer the model parameters and qualitative model construction. Using this model, we discover step-wise genetic alterations that promote cancer development and invasion due to an increase in glycolytic flux, and reveal critical trajectories involved in cancer progression. We compute delay constraints to reveal important associations between the production and degradation rates of proteins. O-linked N-acetylglucosamine transferase (OGT, an enzyme used for addition of O-GlcNAc during O-GlcNAcylation, is identified as a key regulator to promote oncogenesis in a feedback mechanism through the stabilization of c-Myc. Silencing of the OGT and c-Myc loop decreases glycolytic flux and leads to programmed cell death. Results of network analyses also identify a significant cycle that highlights the role of p53-Mdm2 circuit oscillations in cancer recovery and homeostasis. Together, our findings suggest that the OGT and c-Myc feedback loop is critical in tumor progression, and targeting these mediators may provide a mechanism-based therapeutic approach to regulate hyper-O-GlcNAcylation in human cancer.

  15. INTEGRATING VOCATIONAL STREAM IN SECONDARY SCHOOL: A QUALITATIVE CASE STUDY

    Directory of Open Access Journals (Sweden)

    Mohamad Hisyam Mohd. Hashim

    2010-11-01

    Full Text Available Vocational stream is a new set-up in the education system of developing countries especially for countries with low population and limited area of land. Nevertheless, this countries are working on providing vocational education to their citizen particularly for their youngsters in secondary school. There are few important elements or items that can be used as guidence in a certain implementation that might be the basics of the implementation. The qualitative methodology (Inteviews, Documents analysis and observation are used. Research findings show that there are some items that can be adopted as the Guidelines On International Best Practices In Integrating Vocational Education In Secondary School especially for the vocational streamed school. It is also found that, it is still too soon for the implementation of vocational stream in the existing secondary schools if the basic requirements for it are not being formed or improved. It is suggested that, the implementation of International Best Practices in Integrating TVET in the Secondary School which was also being suggested previously for other developing countries by model pathway of voational stream student.

  16. Promoting Vocational Education. A Public Relations Handbook for Vocational Educators.

    Science.gov (United States)

    American Vocational Association, Arlington, VA.

    This handbook for vocational educators was developed as a tool to help them in their public relations efforts. Following a brief introduction, the content is presented in twelve sections. The first discusses the roles of various professionals and groups in vocational education. Section 2 covers planning a total public relations program and…

  17. Distance Education of Vocational High Schools in Turkey

    Directory of Open Access Journals (Sweden)

    Tuğçe GÜNTER

    2012-01-01

    Full Text Available The aim of vocational high schools is to teach qualified, high self-sufficient, self-confident, technical staff who have critical and mathematical thinking competence and who can utilize science and technology efficiently. However, because of the limitations of traditional education, students can not take enough education attendance. In this context; along with the advances in science and technology area, “Web- Based Distance Education Programme”, which provides equal education conditions to students, is developed. This programme has got great progresses in abroad, and has also started to practice in Turkish Vocational High Schools. It is determined that some Vocational High Schools have applied Web-Based Distance Education in Medical Documentation and Secretarial (MDS and Medical Laboratory Techniques (MLT Associate Degree Programmes which are also existed in Bülent Ecevit University (BEU Ahmet Erdoğan Health Services Vocational High School. It is observed that the universities, that implemented distance education in these associate degree programmes, have higher technical infrastructure and they design a constructivism-based modules. It is considered that this distance education programme for MDS and MLT Associate Degree Programmes in certain Vocational Schools, can also be implemented for students in Medical Documentation and Secretarial (MDS and Medical Laboratory Techniques (MLT which continues education by computers and overhead projector that is slightly different from traditional education.

  18. Current Situation in Vocational Schools: Issues and Some Suggested Solutions

    Directory of Open Access Journals (Sweden)

    Reha Metin ALKAN

    2014-12-01

    Full Text Available Vocational Schools which have undertaken various missions throughout history were established in order to train intermediate staff s with suff icient knowledge and skills in their fields, in accordance with the requirements of trade, industry and services sectors and they are the most important components of ‘vocational and technical education system' today. Analyzing the education given in the vocational schools in accordance with the national and international requirements, developing technologies and the needs of business world and making the necessary arrangements in line with these will contribute to the employability and preferability of graduates of these schools in an eff icient way. Many industrialists/businessmen in our country stated that they experienced serious problems in the supply of qualified staff with suff icient knowledge and skills needed in sectors. Although much progress has been achieved in this subject, it is a fact that there are still a lot of work to be done. In this study, current situation and main troubles in vocational schools are discussed in the light of the experiences gained at Hitit University Vocational School which was established about 40 years ago in Çorum and which is one of the first high schools in Turkey and some solutions are suggested in accordance with the problems mentioned.

  19. Glutathione transferases P1/P2 regulate the timing of signaling pathway activations and cell cycle progression during mouse liver regeneration.

    Science.gov (United States)

    Pajaud, J; Ribault, C; Ben Mosbah, I; Rauch, C; Henderson, C; Bellaud, P; Aninat, C; Loyer, P; Morel, F; Corlu, A

    2015-01-15

    Glutathione transferases (GST) are phase II enzymes catalyzing the detoxification of endogenous noxious compounds and xenobiotics. They also regulate phosphorylation activities of MAPKinases in a catalytic-independent manner. Previous studies have demonstrated the regulation of JNK-dependent pathway by GSTP1/2. Considering the crucial role of JNK in the early steps of the hepatocyte cell cycle, we sought to determine whether GSTP1/2 were essential for hepatocyte proliferation following partial hepatectomy (PH). Using a conventional double knockout mouse model for the Gstp1 and Gstp2 genes, we found that the lack of GSTP1/P2 reduced the rate of DNA replication and mitotic index during the first wave of hepatocyte proliferation. The lowered proliferation was associated with the decrease in TNFalpha and IL-6 plasma concentrations, reduced hepatic HGF expression and delayed and/or altered activation of STAT3, JNK and ERK1/2 signaling pathways. In addition, the expression and/or activation of cell cycle regulators such as Cyclin D1, CDK4, E2F1 and MCM7 was postponed demonstrating that the absence of GSTP1/2 delayed the entry into and progression through the G1 phase of the cell cycle and impaired the synchrony of proliferation in hepatocytes following PH. Furthermore, while JNK and its downstream targets c-Jun and ATF2 were activated during the early steps of the liver regeneration in wild-type animals, the constitutively active JNK found in the quiescent liver of Gstp1/2 knockout mice underwent a decrease in its activity after PH. Transient induction of antioxidant enzymes and nitric oxide synthase were also delayed or repressed during the regenerative response. Altogether our results demonstrate that GSTP1/2 are a critical regulators of hepatocyte proliferation in the initial phases of liver regeneration.

  20. Research Progress of Signal Transduction Pathway in Golgi Stress%高尔基体应激信号传导通路研究进展

    Institute of Scientific and Technical Information of China (English)

    杨剑文; 胡治平

    2016-01-01

    高尔基体应激是因脑缺血再灌注等应激反应中,导致高尔基体蛋白质加工运输、分泌等功能改变,与多种细胞内的信号通路是密切相关的。我们综观近年相关文献,并综述其研究进展,结果认为高尔基体应激通过磷酸肌醇、蛋白激酶C/蛋白激酶D、RAS/MAPK激酶、cAMP/PKA等信号通路发挥作用,参与缺血性脑卒中、脊髓损伤及神经变性疾病等发病机制。%Golgi stress is caused by the stress reaction of cerebral ischemia and reperfusion,which lead to the change of the function of the protein processing and transportation and secretion of Golgi protein.Golgi stress is closely related to variety signal transduction pathway in cells.We review the related literature in recent years,and summarize the research progress,The results indicated that Golgi stress plays a role by the signal pathway of phosphoinositide,protein kinase C/protein kinase D,RAS/MAPK kinase,cAMP/PKA kinase,and so on.It is involved in the pathogenesis of ischemic stroke,spinal cord injury,and neurodegenerative diseases.

  1. Legal Scholarship as a Vocation.

    Science.gov (United States)

    Luban, David

    2001-01-01

    Explores the more purely theoretical side of the legal scholar's vocation, using Max Weber's text on the scholar's role titled "Science as a Vocation." Discusses the consequences of the tension between law schools' generalist "pretensions" and increasingly specialist character, and Weber's fact/value distinction. (EV)

  2. A Spotlight on Vocational Learning

    Science.gov (United States)

    Williams, Jenny

    2012-01-01

    Announced by government in "New Challenges, New Chances" in December 2011, the sector-led Commission on Adult Vocational Teaching and Learning has been tasked with raising the quality, and improving the outcomes and impact, of adult vocational teaching and learning for learners and employers. It is a commission focused on the future--of…

  3. A Spotlight on Vocational Learning

    Science.gov (United States)

    Williams, Jenny

    2012-01-01

    Announced by government in "New Challenges, New Chances" in December 2011, the sector-led Commission on Adult Vocational Teaching and Learning has been tasked with raising the quality, and improving the outcomes and impact, of adult vocational teaching and learning for learners and employers. It is a commission focused on the future--of people,…

  4. Vocational Indecision and Rehabilitation Clients.

    Science.gov (United States)

    Strohmer, Douglas C.; And Others

    1984-01-01

    Assessed the vocational decision-making problems of rehabilitation clients (N=60). Revealed that decision-making problems of clients can be grouped into three areas: employment readiness, self-appraisal, and decision-making readiness. Suggested that vocationally decided and undecided subjects differ significantly in the extent to which they have…

  5. Androgen receptor regulated microRNA miR-182-5p promotes prostate cancer progression by targeting the ARRDC3/ITGB4 pathway

    Energy Technology Data Exchange (ETDEWEB)

    Yao, Jingjing [Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, 200433 (China); Xu, Chen [Research Center of Developmental Biology, Second Military Medical University, 800th Xiangyin Road, Shanghai, 200433 (China); Department of Orthopedics, Changzheng Hospital Affiliated to Second Military Medical University, 415th Feng Yang Road, Shanghai, 200003 (China); Fang, Ziyu; Li, Yaoming [Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, 200433 (China); Liu, Houqi; Wang, Yue [Research Center of Developmental Biology, Second Military Medical University, 800th Xiangyin Road, Shanghai, 200433 (China); Translational Medicine Center, Second Military Medical University, 800th Xiangyin Road, Shanghai, 200433 (China); Xu, Chuanliang [Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, 200433 (China); Sun, Yinghao, E-mail: sunyh@medmail.com.cn [Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, 200433 (China)

    2016-05-20

    Abstracts: MicroRNAs (miRNAs) are important endogenous gene regulators that play key roles in prostate cancer development and metastasis. However, specific miRNA expression patterns in prostate cancer tissues from Chinese patients remain largely unknown. In this study, we compared miRNA expression patterns in 65 pairs of prostate cancer and para-cancer tissues by RNA sequencing and found that miR-182-5p was the most up-regulated miRNA in prostate cancer tissues. The result was validated using realtime PCR in 18 pairs of prostate cancer and para-cancer tissues. In in vitro analysis, it was confirmed that miR-182-5p promotes prostate cancer cell proliferation, invasion and migration and inhibit apoptosis. In addition, the androgen receptor directly regulated the transcription of miR-182-5p, which could target to the 3′UTR of ARRDC3 mRNA and affect the expression of ARRDC3 and its downstream gene ITGB4. For the in vivo experiment, miR-182-5p overexpression also promoted the growth and progression of prostate cancer tumors. In this regard, we suggest that miR-182-5p may be a key androgen receptor-regulated factor that contributes to the development and metastasis of Chinese prostate cancers and may be a potential target for the early diagnosis and therapeutic studies of prostate cancer. -- Highlights: •miR-182-5p is the mostly up-regulated miRNA in Chinese prostate cancer. •miR-182-5p is regulated by androgen receptor. •miR-182-5p promotes prostate cancer progression. •miR-182-5p regulates ARRDC3/ITGB4 pathway.

  6. 38 CFR 21.70 - Vocational rehabilitation.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Vocational rehabilitation...) VOCATIONAL REHABILITATION AND EDUCATION Vocational Rehabilitation and Employment Under 38 U.S.C. Chapter 31 Duration of Rehabilitation Programs § 21.70 Vocational rehabilitation. (a) General. The goal of...

  7. Ensuring Quality Assurance in Vocational Education

    Science.gov (United States)

    Idialu, Ethel E.

    2013-01-01

    Vocational education emphasises skill acquisition. Quality assurance in vocational education is a concept that is concerned with high performance involving activities with vocational education such as teaching, learning, infrastructures, students' behaviour and the entire academic process. Quality vocational education refers to input and output of…

  8. Vocational rehabilitation: a multidisciplinary intervention.

    Science.gov (United States)

    Gobelet, C; Luthi, F; Al-Khodairy, A T; Chamberlain, M A

    2007-09-15

    Vocational rehabilitation is by definition a multidisciplinary intervention in a process linked to the facilitation of return to work or to the prevention of loss of the work. Clinical staff in contact with a person who has lost his job (general practitioner, specialized physician) must promote vocational rehabilitation. Medical rehabilitation for those with disabilities, whether new or old, has to be followed without delay by vocational rehabilitation. It is even better if these two intertwined processes are overlapping. They involve many professionals including physiotherapists, occupational therapists, psychologists, vocational trainers, job counsellors, teachers, case-managers, job placement agencies. Vocational rehabilitation has a financial cost, borne by many state organizations (security, social system, social affairs) as well as by employers and private insurances, which are in case of accident, concerned by this process. However, the evidence suggests that this is recouped 2- to 10-fold as suggested by the British Society of Rehabilitation Medicine.

  9. Progress in biodesulfurization microbes with the specific "4S" pathway%“4S”途径生物脱硫菌的研究进展

    Institute of Scientific and Technical Information of China (English)

    万涛; 辛星; 闻建平

    2012-01-01

    与传统的加氢脱硫方法相比,采用“4S”专一途径微生物脱除油品中的硫具有成本和操作费用低、反应条件温和、效率高、无需加氢、低碳排放等优势.文章综述了常见生物脱硫菌、近年来生物脱硫微生物的代谢工程研究情况,并对“4S”专一途径脱硫菌的研究方向,即系统生物学和合成生物学,进行了展望.%Compared with the traditional HDS (hydrodesulfurization) method,the specific "4S" sulfur-degradation pathway has great advantages, such as low operating cost, low carbon dioxide emission, mild reaction conditions, high efficiency and no hydrogenation. In this review, the biodesulfurization bacterium and the research progress in metabolic engineering of those microbes in recent years are summarized. The prospect related to systems biology and synthetic biology is put forward as well.

  10. Vocational Education and Zakat: The Case Study of Punjab Vocational Training Council

    Directory of Open Access Journals (Sweden)

    Iqbal M. KHAN

    2014-08-01

    Full Text Available The aim of this research is to explore the prospect of teaching Entrepreneurship Education to those who acquire vocational skills at Punjab Vocational Training Council (PVTC. It is also to explore whether PVTC has promoted entrepreneurship through its vocational training institutes located all over Punjab. This study also deals with the concept of utilization of ‘Zakat' for the purpose of vocational education as a mode for possible replication. The research objective has been to follow the progress of this institution. It has also been to record the successes of this model of a public-private ownership, a model of utilizing the ‘Zakat' to fund education projects, a value based organization, a learning organization and a highly innovative institution. The other objective is to explore the evidence of entrepreneurship education and its effectiveness in PVTC. Literature has been reviewed on vocational training and entrepreneurship education. It also reviews experience and evidence of such practice prevailing in other environment. Combined with this is the review and conceptualization of a model based on ‘zakat'. Research Methodology used is basically qualitative; data has been collected through semi structured intensive interviews and from focus groups of stakeholders. The strategies adopted to collect data in this study are “survey”, “case study” and “grounded theory.” The data collected from semi structured interviews were concluded by thematic analysis, analyzing technique of writing reports from data. NVivo software was utilized for triangulation to reduce the data bias and increase validity by comparing primary and secondary data. The findings of this research have been that the pedagogical skills offered by PVTC's are not effective for entrepreneurial potential development. Work is required for entrepreneurial curriculum development and training of PVTCs' instructors, students and practitioners. The research also reveals

  11. Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions Vitamin D pathways unbalanced in breast lesions

    Directory of Open Access Journals (Sweden)

    Lopes Nair

    2010-09-01

    Full Text Available Abstract Background Breast cancer is a heterogeneous disease associated with different patient prognosis and responses to therapy. Vitamin D has been emerging as a potential treatment for cancer, as it has been demonstrated that it modulates proliferation, apoptosis, invasion and metastasis, among others. It acts mostly through the Vitamin D receptor (VDR and the synthesis and degradation of this hormone are regulated by the enzymes CYP27B1 and CYP24A1, respectively. We aimed to study the expression of these three proteins by immunohistochemistry in a series of breast lesions. Methods We have used a cohort comprising normal breast, benign mammary lesions, carcinomas in situ and invasive carcinomas and assessed the expression of the VDR, CYP27B1 and CYP24A1 by immunohistochemistry. Results The results that we have obtained show that all proteins are expressed in the various breast tissues, although at different amounts. The VDR was frequently expressed in benign lesions (93.5% and its levels of expression were diminished in invasive tumours (56.2%. Additionally, the VDR was strongly associated with the oestrogen receptor positivity in breast carcinomas. CYP27B1 expression is slightly lower in invasive carcinomas (44.6% than in benign lesions (55.8%. In contrast, CYP24A1 expression was augmented in carcinomas (56.0% in in situ and 53.7% in invasive carcinomas when compared with that in benign lesions (19.0%. Conclusions From this study, we conclude that there is a deregulation of the Vitamin D signalling and metabolic pathways in breast cancer, favouring tumour progression. Thus, during mammary malignant transformation, tumour cells lose their ability to synthesize the active form of Vitamin D and respond to VDR-mediated Vitamin D effects, while increasing their ability to degrade this hormone.

  12. A virtual reality-based vocational training system (VRVTS) for people with schizophrenia in vocational rehabilitation.

    Science.gov (United States)

    Tsang, Mayie M Y; Man, David W K

    2013-03-01

    Employment provides schizophrenic patients with a positive identity and hope. Cognitive impairments have been suggested to slow down the progress in work rehabilitation. The purpose of this study was to investigate the efficacy and effectiveness of VR as a cognitive intervention for enhancing vocational outcomes. 95 inpatients with schizophrenia were randomly assigned to a virtual reality-based vocational training group (VRG), a therapist-administered group (TAG) and a conventional group (CG). Twenty-five of them in each group had completed the study. Their performances were evaluated, before and after interventions, by Brief Neuropsychological Cognitive Examination, Digit Vigilance Test, Rivermead Behavioural Memory Test, Wisconsin Card Sorting Test (WCST) and Vocational Cognitive Rating Scale. Patients in the VRG were found to perform better than patients in the TAG and CG in cognitive functioning, as shown by the WCST-percentage of error (F (2, 72)=7.146, p<0.001) and the WCST-percentage of conceptual level response (F (2, 72)=8.722, p<0.001). The post-hoc test revealed that the VRG showed a better performance than both the TAG (p=0.03) and the CG (p<0.001) in the WCST-percentage of error. The VRG also showed a better performance than patients in both the TAG (p=0.01) and the CG (p<0.001) in the WCST-percentage of conceptual level response. The VRG also showed a better self-efficacy score than CG. Both VRG and TAG showed a better work performance as reflected by the on-site tests. Further studies on the use of VR in schizophrenia rehabilitation and for vocational success are discussed.

  13. Carrying-over effects of GVBD blocking on post-blocking meiotic progression of oocytes: species difference and the signaling pathway leading to MPF activation.

    Directory of Open Access Journals (Sweden)

    Guang-Zhong Jiao

    Full Text Available Efforts to improve the quality of in vitro matured oocytes by blocking germinal vesicle breakdown (GVBD and allowing more time for ooplasmic maturation have achieved little due to a lack of knowledge on the molecular events during GVBD blocking. Such knowledge is also important for studies aimed at regulating gene expression in maturing oocytes prior to GVBD. We studied species difference and signaling pathways leading to the carrying-over effect of GVBD blocking on post-blocking meiotic progression (PBMP. Overall, GVBD-blocking with roscovitine decelerated PBMP of mouse oocytes but accelerated that of pig oocytes. During blocking culture, whereas cyclin B of pig oocytes increased continuously, that of mouse oocytes declined first and then increased slowly. In both species, (a whereas active CDC2A showed a dynamics similar to cyclin B, inactive CDC2A decreased continuously; (b when oocytes were blocked in blocking medium containing cycloheximide, PBMP was decelerated significantly while cyclin B and active CDC2A decreasing to the lowest level; (c whereas sodium vanadate in blocking medium reduced PBMP, epidermal growth factor (EGF in blocking medium accelerated PBMP significantly with no effect on cyclin B levels. In conclusion, the EGF signaling cascade accelerated PBMP by promoting the pre-MPF (M-phase-promoting factor to MPF conversion during GVBD blocking with roscovitine. The significant difference in PBMP observed between mouse and pig oocytes was caused by species difference in cyclin B dynamics during blocking culture as no species difference was observed in either pre-MPF to MPF conversion or the EGF signaling activity.

  14. Carrying-Over Effects of GVBD Blocking on Post-Blocking Meiotic Progression of Oocytes: Species Difference and the Signaling Pathway Leading to MPF Activation

    Science.gov (United States)

    Jiao, Guang-Zhong; Lian, Hua-Yu; Gao, Yan; Sun, Ming-Ju; Gong, Shuai; Zheng, Liang-Liang; Zhang, Chuan-Xin; Tan, Jing-He

    2014-01-01

    Efforts to improve the quality of in vitro matured oocytes by blocking germinal vesicle breakdown (GVBD) and allowing more time for ooplasmic maturation have achieved little due to a lack of knowledge on the molecular events during GVBD blocking. Such knowledge is also important for studies aimed at regulating gene expression in maturing oocytes prior to GVBD. We studied species difference and signaling pathways leading to the carrying-over effect of GVBD blocking on post-blocking meiotic progression (PBMP). Overall, GVBD-blocking with roscovitine decelerated PBMP of mouse oocytes but accelerated that of pig oocytes. During blocking culture, whereas cyclin B of pig oocytes increased continuously, that of mouse oocytes declined first and then increased slowly. In both species, (a) whereas active CDC2A showed a dynamics similar to cyclin B, inactive CDC2A decreased continuously; (b) when oocytes were blocked in blocking medium containing cycloheximide, PBMP was decelerated significantly while cyclin B and active CDC2A decreasing to the lowest level; (c) whereas sodium vanadate in blocking medium reduced PBMP, epidermal growth factor (EGF) in blocking medium accelerated PBMP significantly with no effect on cyclin B levels. In conclusion, the EGF signaling cascade accelerated PBMP by promoting the pre-MPF (M-phase-promoting factor) to MPF conversion during GVBD blocking with roscovitine. The significant difference in PBMP observed between mouse and pig oocytes was caused by species difference in cyclin B dynamics during blocking culture as no species difference was observed in either pre-MPF to MPF conversion or the EGF signaling activity. PMID:25078078

  15. The Involvement of Corin in the Progression of Diabetic Erectile Dysfunction in a Rat Model by Down-Regulating ANP /NO/cGMP Signal Pathway.

    Science.gov (United States)

    Wang, Jian; Mi, Yuanyuan; Yuan, Fenglai; Wu, Sheng; You, Xiaoming; Dai, Feng; Huang, Yi; Cao, Jia; Zhu, Jin; Xue, Boxin; Zhu, Lijie

    2017-01-20

    This study was aimed to analyze the potential role of Corin in the procession of diabetic ED and to explore the underlying mechanism. Diabetic ED rat model was constructed and the characteristics of diabetic ED and control rats were recorded at 4, 8, 12 and 16 weeks. qRT-PCR and Western bloting were used to detected the mRNA and protein levels. Intracellular cGMP detection was accomplished using a commercial radioimmunoassay method. Vascular endothelial cell from rat corpus cavernosum spiral artery was isolated and transfected with si- Corin to analyzed the potential role of Corin. Cell viability was assessed using crystal violet. The results showed that diabetic ED rats showed significantly higher glucose level, and lower body weight, ICP level and ICP/MAP ratio at 12 and 16 weeks in diabetic ED rats compared with control rats. The protein levels of Corin, atrial natriuretic peptide (ANP)and eNOS, and the level of cGMP were significantly down-regulated in corpus cavernosum in diabetic ED rats, revealing the potential role of Corin in NO-associated diabetic ED. Further studies proved that defect of Corin not only inhibited the vascular endothelial cell viability in high-glucose condition, but also suppressed ANP, eNOS and cGMP expression in vascular endothelial cells. To sum up, Corin contributes to the progression of diabetic ED and the underlying mechanism is associated with the down-regulation of ANP /NO/cGMP signal pathway. This article is protected by copyright. All rights reserved.

  16. PDGF-D/PDGFRβ promotes tongue squamous carcinoma cell (TSCC) progression via activating p38/AKT/ERK/EMT signal pathway.

    Science.gov (United States)

    Zhang, Hong; Sun, Jia-Dong; Yan, Ling-Jian; Zhao, Xiao-Peng

    2016-09-16

    Platelet-derived growth factor D (PDGF-D) signaling plays significant roles during the development and progression of human malignancies via interacting with the receptor of PDGF-D (PDGFR). Meanwhile, the majority of human tumor metastasis is closely associated with epithelial-mesenchymal transition (EMT). However, the underlying mechanism between PDGF-D/PDGFR signaling and EMT which involved in tumor metastasis remain dismal. This study aimed to investigate the role of PDGF-D signaling during EMT process of tongue squamous cell carcinoma (TSCC). In our study, the expression of PDGF-D and PDGFR were examined in primary TSCC samples and the expression of PDGF-D was also determined in TSCC cell lines. In addition, the correlation between PDGF-D expression and TSCC aggressive histopathological features was analyzed. Our results implied that upregulation of PDGFRβ in UM1 cells induced with exogenous PDGF-D can remarkably promote tumor cells invasiveness; conversely, when using small interfering RNA (siRNA), the invasiveness can be severely prohibited. Furthermore, PDGF-D downstream signal molecules p38, AKT, ERK and EMT biomarkers (E-cadherin, N-cadherin, Vimentin and snail) were measured using Western blot. Our results showed that PDGF-D can induce p38, AKT and ERK phosphorylation; downregulate epithelial markers and upregulate mesenchymal markers. On the contrary, PDGFRβ siRNA significantly prohibited p38, AKT and ERK phosphorylation; inhibited EMT process. Function analysis revealed that PDGFRβ siRNA obviously interfered with UM1 cell migration and invasion, according to transwell and wound healing assay. In conclusion, this study suggested that EMT process can be triggered by the PDGF-D/PDGFRβ axis in TSCC, and then involved in the tumor cell invasion via activation of p38/AKT/ERK/EMT pathway. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. Namibia - Vocational Training Grant Fund

    Data.gov (United States)

    Millennium Challenge Corporation — The impact evaluation of the Vocational Training Grant Fund (VTGF) subactivity in Namibia uses a random assignment design to determine the effects of VTGF-funded...

  18. Vocatives and discourse markers in textualinteractive grammar

    Directory of Open Access Journals (Sweden)

    Eduardo Penhavel

    2012-12-01

    Full Text Available In this paper, we discuss the class of Vocatives and the class of Discourse Markers as proposed within Textualinteractive Grammar, and we try to demonstrate that Vocatives can work as Discourse Markers.

  19. Imperatives of Vocational Education and Sustainable Development ...

    African Journals Online (AJOL)

    Toshiba

    vocational education play in contributing to sustainable development is the focal point ... and vocational education as a comprehensive term referring to those aspects of the ... technical institutions are highly skilled entrepreneurs. They rely on.

  20. Vocational Education and Equality of Opportunity.

    Science.gov (United States)

    Horowitz, Benjamin; Feinberg, Walter

    1990-01-01

    Examines the concepts of equality of opportunity and equality of educational opportunity and their relationship to vocational education. Traces the history of vocational education. Delineates the distinction between training and education as enumerated in Aristotelian philosophy. Discusses the role vocational education can play in the educative…

  1. Connecting Mathematics Teaching with Vocational Learning

    Science.gov (United States)

    Dalby, Diane; Noyes, Andrew

    2015-01-01

    For many vocational students in England, mathematics is now a compulsory part of their programme, yet the inclusion of an academic subject within a vocational course presents challenges. In this paper, an analysis of a series of case studies of vocational student groups in Further Education colleges in England shows how contrasting practices in…

  2. Vocation as the Quest for Authentic Existence.

    Science.gov (United States)

    Homan, Kenneth B.

    1986-01-01

    Examines the concept of vocation and demonstrates that vocation is the organizing, existential principle of the concept of work. Presents a critical examination of Green's (1968) delineation of job and work and asserts that vocation as the quest for authentic existence is the unifying concept that gives grounding to Green's notion of work. (NB)

  3. Strategies for Translating Vocative Texts

    Directory of Open Access Journals (Sweden)

    Olga COJOCARU

    2014-12-01

    Full Text Available The paper deals with the linguistic and cultural elements of vocative texts and the techniques used in translating them by giving some examples of texts that are typically vocative (i.e. advertisements and instructions for use. Semantic and communicative strategies are popular in translation studies and each of them has its own advantages and disadvantages in translating vocative texts. The advantage of semantic translation is that it takes more account of the aesthetic value of the SL text, while communicative translation attempts to render the exact contextual meaning of the original text in such a way that both content and language are readily acceptable and comprehensible to the readership. Focus is laid on the strategies used in translating vocative texts, strategies that highlight and introduce a cultural context to the target audience, in order to achieve their overall purpose, that is to sell or persuade the reader to behave in a certain way. Thus, in order to do that, a number of advertisements from the field of cosmetics industry and electronic gadgets were selected for analysis. The aim is to gather insights into vocative text translation and to create new perspectives on this field of research, now considered a process of innovation and diversion, especially in areas as important as economy and marketing.

  4. The Advantage of Going For Vocational Education

    Institute of Scientific and Technical Information of China (English)

    王文辉

    2008-01-01

    With the entering of the 21st century,information technology has become the world's economic and social development trend,China is beginning to see vocational education as important to maintaining fast economic growth and social stability.Every one wants to have a lucrative career and bright future.That is the reason why most people these days take up vocational education.Vocational education is a type of educational attainment that teaches the student trade skills and aptitudes.Vocational school is a school that provides vocational education to individuals who desire to be trained in job-specific skills.

  5. From apprenticeship to higher vocational education in Denmark

    DEFF Research Database (Denmark)

    Jørgensen, Christian Helms

    2017-01-01

    policy problem in Denmark. Secondly, it explores political initiatives taken to ‘build bridges’ to higher education. Thirdly, it examines the development of technical higher vocational education, which has been a main destination for the former apprentices. Lastly, it examines changes in the transition......Upper secondary vocational education in Denmark is based on the apprenticeship model, which is recognised as a valuable route to employment for young people, who are not aiming for higher education. However, the apprenticeship model has a major weakness: it does not provide eligibility for higher...... education. The purpose of this article is to examine this problem in a historical perspective. The article builds on a combination of policy studies, statistical cohort studies and interview studies. First, the article explores why progression from apprenticeship to higher education has become a major...

  6. Hedgehog信号通路在白血病中的研究进展%Research progress of Hedgehog signaling pathway in leukemia

    Institute of Scientific and Technical Information of China (English)

    王焱

    2015-01-01

    Hedgehog signaling pathway is an important signaling pathway in human body.Human Hedgehog signaling pathway plays a crucial role in embryogenesis,organ development and maintain homeostasis.Studies have shown aberrant activation of the Hedgehog signaling pathway is closely related to various types of malignancies including hematological malignancies.This article will review the constitute of Hedgehog signaling pathway,Hedgehog pathway research status in leukemia and its prospect in leukemia therapy.%Hedgehog信号通路是人体内的重要信号通路之一.人类Hedgehog信号通路在胚胎发育、组织器官形成及维持机体内环境稳定等生理过程中发挥重要作用,同时与肿瘤的发生和发展也有着密切的关系.新近研究发现Hedgehog信号通路异常活化与血液肿瘤的发生、发展密切相关.现从Hedgehog信号通路的组成,其与造血调控及白血病的关系,以及针对Hedgehog信号通路的靶向治疗等方面,就近年来,Hedgehog信号通路及Hedgehog信号通路抑制剂在白血病的研究进展综述如下.

  7. The effectiveness of vocational education in promoting equity and occupational mobility amongst young people

    Directory of Open Access Journals (Sweden)

    Bartlett Will

    2009-01-01

    Full Text Available This paper reviews current knowledge about the impact of vocational education and training on the labor market outcomes for young people in advanced market economies, and asks whether the results can be extrapolated to countries in the Western Balkans and the EU neighborhood. It draws four main policy conclusions. First, in transition countries, specialized vocational education should not be replaced by streaming or tracking within comprehensive school systems or integrated into general education programmes. Abandoning effective vocational schooling may worsen the labor market outcomes for the less able and disadvantaged young people. Inadequate vocational school systems should be strengthened, while ensuring effective pathways to higher levels of education. Second, while apprenticeship systems enable lower ability students and minorities to access the labor market, they may lock women into traditional female occupations. Well-organized and resourced school-based vocational education may be preferred by women who feel they could benefit from them, and may furthermore reduce school drop-out rates. Third, occupational mobility can be improved by effective school-based vocational education. If returns to such education are sufficiently high, they can incentives mobility. While for developed economies there is little difference in rates of return between general and vocational education, in transition economies, returns to vocational education are higher than returns to general education. Fourth, while occupational mobility is needed for countries undergoing structural change, it should be noted that too much mobility can also be harmful to the skill retention, especially for women. Special attention should therefore be given to providing complementary opportunities for retraining and for lifelong learning to all workers, but especially to women, to encourage and support the desired degree of mobility in the labor market.

  8. Attractiveness of Initial Vocational Education and Training: Identifying What Matters. Research Paper No 39

    Science.gov (United States)

    Cedefop - European Centre for the Development of Vocational Training, 2014

    2014-01-01

    Stereotypes prevail: many Europeans still opt for a vocational educational pathway as second choice when deciding about a future career. Despite being high on European and national policy agendas for more than a decade, and despite all efforts made, VET is no more attractive in most countries today than it was some years ago. Building on a system…

  9. Gender Differences in Holland Vocational Personality Types: Implications for School Counselors

    Science.gov (United States)

    Turner, Sherri L.; Conkel, Julia L.; Starkey, Michael; Landgraf, Rachel; Lapan, Richard T.; Siewert, Jason J.; Reich, Allison; Trotter, Michelle J.; Neumaier, Eric R.; Huang, Ju-Ping

    2008-01-01

    The study in this article examined gender and ethnic differences in the development of Holland (1997) personality types among inner-city adolescents. Results showed gender but not ethnic differences in vocational personality types and their predictors, and suggest different pathways to the development of these types for boys and girls. Suggestions…

  10. A Brief Discussion on Streaming Teaching for Non-English Majors in Vocational & Technological Colleges

    Institute of Scientific and Technical Information of China (English)

    武德力

    2008-01-01

    Streaming teaching is adopted gradually for non-English majors in some vocational & technological colleges,and in this thesis the advantages and problems of the method are discussed according to the teaching practice.Furthermore,as a consideration of the streaming teaching,much more progress is expected to be made in the future English teaching with the help of the thesis.

  11. Trends in Outcomes of the Vocational Rehabilitation Program for Adults with Developmental Disabilities: 1995-2005

    Science.gov (United States)

    Migliore, Alberto; Butterworth, John

    2008-01-01

    This article describes national trends in outcomes of the vocational rehabilitation (VR) program, with a focus on adults with developmental disabilities during the period of 1995 to 2005. Findings show that the VR program has made substantial progress in excluding extended employment from the array of possible employment closures. Efforts are…

  12. Technical and Vocational Education in Cameroon and Critical Avenues for Development

    Science.gov (United States)

    Che, S. Megan

    2007-01-01

    Technical and vocational education (TVE) can influence development and economic progress for post-colonial societies. Some newly independent sub-Saharan African countries attempted curricular transformation that might produce a skilled workforce through widespread access to versions of TVE. In Cameroon, no such post-colonial curricular revolution…

  13. Research progress of targeting protein kinase B pathway in gastric cancer%胃癌中靶向蛋白激酶B通路的研究进展

    Institute of Scientific and Technical Information of China (English)

    徐扬; 施维

    2012-01-01

    The activation of protein kinase B (PKB/AKT) pathway is the main reason of development,metastasis and chemotherapy resistance of gastric cancer.In this paper,the relationship between AKT pathway and gastric cancer and AKT pathway-targeting therapy are reviewed.%蛋白激酶B(protein kinase B,PKB,又称AKT)通路的过度活化是胃癌发病、转移以及化疗耐药的主要原因.此文对胃癌与AKT通路的关系以及靶向抑制AKT通路的研究现状和前景做一综述.

  14. Vocational perspectives and neuromuscular disorders

    NARCIS (Netherlands)

    Andries, F; Wevers, CWJ; Wintzen, AR; Busch, HFM; Howeler, CJ; deJager, AEJ; Padberg, GW; deVisser, M; Wokke, JHJ

    1997-01-01

    The present study analyses the actual occupational situation, vocational handicaps and past labour career of a group of about 1000 Dutch patients suffering from a neuromuscular disorder (NMD). On the basis of the likelihood of a substantial employment history and sufficient numbers of patients, four

  15. Vocationally Oriented Language Learning Revisited

    Science.gov (United States)

    Vogt, Karin; Kantelinen, Ritva

    2013-01-01

    Vocationally oriented language learning (VOLL) is often seen as a part of English for Specific Purposes/Language for Specific Purposes (ESP/LSP), which it is not in every case. The diverging characteristics and lines of development that these two branches of ELT have undergone are outlined and contrasted. Then, a discussion of the added value of a…

  16. Progress in stress-induced heat shock signaling pathways%应激相关的热休克信号转导通路的研究进展

    Institute of Scientific and Technical Information of China (English)

    李煜生; 姜勇

    2005-01-01

    A lot of diseases (e.g., acute infarction and infections ) and the diversity of hamtful environmental changes ,including elevating temperature, heavy metals and oxidants damage many kinds of proteins in organism. The denatured proteins usually evoke endogenous adaptive cellular mechanisms called heat shock response. After the activation, heat shock factors (HSFs) bind with heat shock dement (HSE). This progress induces heat shock protein (HSP) expression, then facilitates repair of misfolded proteins, and finally inhibits the cell death (both necrosis and apoptosis) pathways. This review will introduce the structures and functions of HSF, HSP and HSE and details on the signaling process of HSP regulation by HSF.

  17. Vocational teachers and the notion of ’good teaching’

    DEFF Research Database (Denmark)

    Duch, Henriette; Jensen, Lars Bang

    2016-01-01

    lines of education. Vocational teachers thus hail from a diverse range of vocational- and educational backgrounds and experience. The pedagogical course envisioned as a universal pedagogical training thus has an intrinsic problematic when facing the differentiated background and vocational training...

  18. Problems in Employment Trend of Higher Vocational Graduates and Countermeasures

    Science.gov (United States)

    Tan, Jianhua; Sheng, Zhichong

    2011-01-01

    Based on analyzing the regional character of higher vocational graduates employment, this paper analyzes the reasons for this employment trend, advances relevant countermeasures for employment of higher vocational graduates, and explores the direction for higher vocational graduates employment.

  19. Osthole mitigates progressive IgA nephropathy by inhibiting reactive oxygen species generation and NF-κB/NLRP3 pathway.

    Directory of Open Access Journals (Sweden)

    Kuo-Feng Hua

    Full Text Available Renal reactive oxygen species (ROS and mononuclear leukocyte infiltration are involved in the progressive stage (exacerbation of IgA nephropathy (IgAN, which is characterized by glomerular proliferation and renal inflammation. The identification of the mechanism responsible for this critical stage of IgAN and the development of a therapeutic strategy remain a challenge. Osthole is a pure compound isolated from Cnidiummonnieri (L. Cusson seeds, which are used as a traditional Chinese medicine, and is anti-inflammatory, anti-apoptotic, and anti-fibrotic both in vitro and in vivo. Recently, we showed that osthole acts as an anti-inflammatory agent by reducing nuclear factor-kappa B (NF-κB activation in and ROS release by activated macrophages. In this study, we examined whether osthole could prevent the progression of IgAN using a progressive IgAN (Prg-IgAN model in mice. Our results showed that osthole administration resulted in prevention of albuminuria, improved renal function, and blocking of renal progressive lesions, including glomerular proliferation, glomerular sclerosis, and periglomerular mononuclear leukocyte infiltration. These findings were associated with (1 reduced renal superoxide anion levels and increased Nrf2 nuclear translocation, (2 inhibited renal activation of NF-κB and the NLRP3 inflammasome, (3 decreased renal MCP-1 expression and mononuclear leukocyte infiltration, (4 inhibited ROS production and NLRP3 inflammasome activation in cultured, activated macrophages, and (5 inhibited ROS production and MCP-1 protein levels in cultured, activated mesangial cells. The results suggest that osthole exerts its reno-protective effects on the progression of IgAN by inhibiting ROS production and activation of NF-κB and the NLRP3 inflammasome in the kidney. Our data also confirm that ROS generation and activation of NF-κB and the NLRP3 inflammasome are crucial mechanistic events involved in the progression of the renal disorder.

  20. Progress of signaling pathways abnormal in multiple sclerosis%多发性硬化症信号传导通路异常研究进展

    Institute of Scientific and Technical Information of China (English)

    郑娜; 王奇; 尹琳琳

    2015-01-01

    The pathogenesis of multiple sclerosis ( MS) involves alterations to multiple pathways and processes, which represent a significant challenge for developing more-effective therapies.In MS, abnormalities have been identified in several cytokine-signaling pathways, as well as those of other immune receptors.Among the downstream molecules implicated are Jak/Stat, NF-κb, ERK1/2, p38 or Jun/Fos, current MS drugs target some of these pathways.This article will with the aid of the latest research results of systems biology approaches that study pathway dysregulation in the process of MS development, targeting these relevant MS-signaling pathways, offers the opportunity to accelerate the development of novel individual or combination therapies for the future of new drug research.%多发性硬化症的病因涉及多种信号传导途径改变,这就为我们研发更加有效的治疗药物提出了更大挑战。已知在多发性硬化症中多种细胞因子及其受体信号传导异常,根据其下游效应分子不同分为:Jak/Stat, NF-κB, ERK1/2, p38 or Jun/Fos通路等。目前仅有部分多发性硬化症治疗药物靶向上述信号通路,本文将综述系统生物学最新研究成果分别阐述多发性硬化症发生发展过程中信号通路的异常,为今后靶向上述通路的新药研发提供个体化或复合型治疗策略。

  1. Vocational and Technical Education for the Future Act. Report Together with Additional Views. House of Representatives, One Hundred Ninth Congress, First Session (March 17, 2005). Report 109-25

    Science.gov (United States)

    US House of Representatives, 2005

    2005-01-01

    H.R. 366, the Vocational and Technical Education for the Future Act, strengthens and improves the Carl D. Perkins Vocational and Technical Education Act by enhancing local accountability, introducing model sequences of courses that incorporate both secondary and postsecondary elements in a non-duplicative progression of courses, and merging the…

  2. A REVIEW OF THE TRANSVERSE MODULES OF THE FORMATIVE CYCLES OF VOCATIONAL STUDIES

    Directory of Open Access Journals (Sweden)

    Joan Solsona Solé

    2015-12-01

    On observing the educational centres which provide higher vocational training courses it is noted that there is a high number of students who do not participate in lifelong learning in a very important aspect of their lives as employability and entrepeneurship as they have the transversal modules of Training and Employment Guidance and Bussiness and Entrepreneurship validated. Therefore, it is proposed to implement a progressive curricular model of the before mentioned modules in the middle and higher vocational training courses, detailing and differentiating the respective professional profiles.

  3. Research progress of Sonic Hedgehog signaling pathway and its targeted inhibitors in ;medulloblastoma%髓母细胞瘤SHH信号通路及靶向抑制剂研究进展

    Institute of Scientific and Technical Information of China (English)

    林中啸; 蔡铭; 盛汉松; 张弩

    2014-01-01

    SHH信号通路在小脑的发育形成过程中发挥着重要作用,能够调控小脑细胞正常发育周期及细胞增殖,维持小脑正常的功能和结构。SHH信号通路异常激活会出现小脑细胞异常增殖而导致髓母细胞瘤(MB)发生,是MB形成过程中最具有特异性的通路之一。针对SHH信号通路靶向抑制剂治疗将成为治疗MB的新方法,能特异性地阻断特定信号转导途径,靶向于肿瘤细胞的微环境及分子表达从而抑制肿瘤生长和转移。本文就MB发病机制中的SHH信号通路和基于该信号通路靶向抑制剂的研究进展作一综述。%Sonic Hedgehog (SHH) signaling pathway plays an important role in the formation process in the development of the cerebellum. It can regulate the normal development of the cerebellum cell cycle and cell proliferation to maintain normal function and structure of the cerebellum. Aberrant SHH signaling pathway causes severe cerebellar development and medulloblastoma (MB). Targeted for SHH signaling pathway inhibitor treatment will become a new treatment for MB, specificity to block certain signal transduction pathways, targeted to the microenvironment of tumor cells and molecules expression to inhibit tumor growth and metastasis. This review summarized the research progress of SHH signaling pathway and its targeted inhibitors in MB.

  4. The Stages of Vocational/Academic Integration for Vocational Educators. Tip Sheet #5.

    Science.gov (United States)

    Kisner, Mary J.

    This brief suggests that vocational educators may be unclear as to whether they have accomplished integration of vocational and academic education because of the multistage nature of the process. The three stages suggest a continuum of professional growth, as vocational and academic educators first become aware of limitations of the status quo,…

  5. Identity Change during Vocational Teacher Education

    DEFF Research Database (Denmark)

    Duch, Henriette

    New vocational teachers cross a boundary when they move from one occupation to a job as teacher. A vocational teacher already has an education when he becomes a teacher. He also has several years of work experience. In Denmark, the educational background is related to the type of vocational schoo...... educations, reduce dropout rates and increase the supply of labor. The theoretical framework is identity theories....

  6. Scientific research projects in vocational training schools

    OpenAIRE

    2010-01-01

    Vocational schools are a resource for many students, with usually low motivation and high learning difficulties. The fact that this type of teaching is of a more practical, experimental, and job oriented type, points to teaching strategies less theoretical and focus on a more practical student involvement. Profiting from those characteristics, the study of the use of scientific projects on vocational teaching was initiated. It was proposed to vocational school st...

  7. Vocational teachers' identity formation through boundary crossing

    OpenAIRE

    Fejes, Andreas; Köpsén, Susanne

    2014-01-01

    Vocational teachers’ prior occupational experiences are construed as those that will guarantee high-quality teaching in vocational education, although individuals are no longer required to have formal teaching qualifications to be employed as teachers in Sweden. This lack of strict requirements raises the issue of the preparedness of vocational teachers to teach their subject matter. Drawing on a socio-cultural understanding of identity, and based on twenty semi-structured interviews with voc...

  8. Progress of sonic hedgehog signaling pathway regulating pain sensitization%Sonic hedgehog信号通路调节痛觉敏化的研究进展

    Institute of Scientific and Technical Information of China (English)

    冯晓雪(综述); 刘丹彦(审校)

    2015-01-01

    神经病理性痛是一种由于躯体感觉神经系统的损伤或疾病而直接造成的疼痛。Sonic hedgehog(Shh)信号转导通路是经典的控制胚胎发育的信号转导途径。近年来发现,该信号途径不仅参与胚胎神经系统模式发育,在成熟机体的稳态调节中也发挥重要作用,因此正逐渐成为信号转导领域新的研究热点。最新文献表明,Shh通路调节神经病理性疼痛的痛觉敏化,且其可能机制与星形胶质细胞激活,炎症因子以及突触可塑性的改变相关。%Neuropathy pain is a kind of pain due to injury or disease to the body of sensory nerve system. Sonic hedgehog (Shh) signal transduction pathway is a classic control signal transduction pathways in embryonic development. And it be found that the signaling pathways involved in the development of the nervous system model in mature steady state, so is becoming a hot spot in the ifeld of new signal transduction. Novel studies have demonstrated that the Shh pathway is associated with pain sensitization in neuropathy pain. And its mechanism maybe about astrocyte activation, inlfammation factors and the change of the synaptic plasticity.

  9. Mechanism of right thoracic adolescent idiopathic scoliosis at risk for progression; a unifying pathway of development by normal growth and imbalance

    DEFF Research Database (Denmark)

    Wong, Christian

    2015-01-01

    Adolescent idiopathic scoliosis is regarded as a multifactorial disease and none of the many suggested causal etiologies have yet prevailed. I will suggest that adolescent idiopathic scoliosis has one common denominator, namely that initial curve development is mediated through one common normal...... of adolescent idiopathic scoliosis should address this physiological pathway and the overall treatment strategy is early intervention with strengthening of thoracic rotational stability for small curve adolescent idiopathic scoliosis....

  10. VOCATIONAL PEDAGOGY A DIMENSION OF VOCATIONAL LEARNING WITH WORKPLACE REQUIREMENT

    OpenAIRE

    Mimi Mohaffyza Mohamad; Yee Mei Heong; Tee Tze Kiong; Muhammad Rashid Rajuddin

    2012-01-01

    Rapid changes are taking place in industry, the labor market, work to work organization. The changes of taking places in industry have an important implication for Vocational Education and Training (VET). These widespread changes have significant implications for the learning requirement of workers and for the pedagogical methods to facilitate that learning. This paper focuses in the learning of instructor, learners in the perspective of their readiness with teaching and learning challenge in...

  11. VOCATIONAL PEDAGOGY A DIMENSION OF VOCATIONAL LEARNING WITH WORKPLACE REQUIREMENT

    OpenAIRE

    Mimi Mohaffyza Mohamad; Yee Mei Heong; Tee Tze Kiong; Muhammad Rashid Rajuddin

    2012-01-01

    Rapid changes are taking place in industry, the labor market, work to work organization. The changes of taking places in industry have an important implication for Vocational Education and Training (VET). These widespread changes have significant implications for the learning requirement of workers and for the pedagogical methods to facilitate that learning. This paper focuses in the learning of instructor, learners in the perspective of their readiness with teaching and learning challenge in...

  12. Hedgehog信号通路在前列腺癌中的研究进展%Progression of Hedgehog signal pathway in prostate cancer

    Institute of Scientific and Technical Information of China (English)

    孙全武; 迟强; 周逢海

    2009-01-01

    Hedgehog信号通路与哺乳动物的胚胎发育、组织发生以及肿瘤形成等有着密切的关系,在机体发育过程中调节细胞的增殖与分化.研究证实其在晚期前列腺癌中起着重要作用.在前列腺肿瘤异种移植动物模型中,将Hedgehog信号通路阻断后可以使瘤体变小.因此,靶向抑制Hedgehog信号通路可能对前列腺癌的治疗非常有效.%Hedgehog signal pathway has close relationship with fetal development, histogenesis and carcinogenesis in mammalian. Recent studies have uncovered the role of Hedgehog signal pathway in advanced prostate cancer. Blockade of Hedgehog signal pathway leads to tumor shrinkage and remission in tumor xenograft models. Thus, targeted inhibition of Hedgehog signaling may have significant implications of prostate cancer therapeutics.

  13. Recent progress of Notch-1 signaling pathway in tumor research%Notch-1信号通路在肿瘤中的研究进展

    Institute of Scientific and Technical Information of China (English)

    张庆庆(综述); 陈伟; 张森林(审校)

    2014-01-01

    As one of members of the Notch gene family , Notch-1 signaling pathway plays an important role in the processing of cell proliferation , differentiation , survival and apoptosis .The abnormal expression of Notch-1 is closely related to tumorigenesis and de-velopment .In recent years , many studies have focused on the relationship between the Notch-1 signaling pathway and tumor .This arti-cle reviews the achievement of Notch-1 signaling pathway in recent tumor researches .%Notch-1是Notch基因家族的成员之一,Notch-1信号通路在细胞的增殖、分化、生存和凋亡中起着重要作用,其异常表达与肿瘤的发生、发展密切相关。近年来, Notch-1信号通路和肿瘤的关系研究颇多。文中就该信号通路在肿瘤中的研究进展作一综述。

  14. VOCATIONAL PEDAGOGY A DIMENSION OF VOCATIONAL LEARNING WITH WORKPLACE REQUIREMENT

    Directory of Open Access Journals (Sweden)

    Mimi Mohaffyza Mohamad

    2012-07-01

    Full Text Available Rapid changes are taking place in industry, the labor market, work to work organization. The changes of taking places in industry have an important implication for Vocational Education and Training (VET. These widespread changes have significant implications for the learning requirement of workers and for the pedagogical methods to facilitate that learning. This paper focuses in the learning of instructor, learners in the perspective of their readiness with teaching and learning challenge in VET. Some theoretical consideration in behavioral and cognitive psychology will be discussed derived from the concept of learning content vocational institutions; pedagogical strategies such as demonstration, practice and feedback implemented by the instructors for learning occur. The learners’ preferences based on their characteristics to cater their ability to learn in VET. Learners’ learning styles were investigated to identify their preferences in learning and match with the curriculum and practices in teaching VET. The shift in pedagogical orientation will focus in potential of individual, engage learners in development of their own vocational knowledge and skills. VET instructors and trainers must be able to recognize and adapt their teaching and learning practice in order to response to these needs.

  15. Nursing: Licensed Practical and Licensed Vocational Nurses

    Science.gov (United States)

    ... Projected Employment, 2024 Change, 2014-24 Employment by Industry Percent Numeric SOURCE: U.S. Bureau of Labor Statistics, Employment Projections program Licensed practical and licensed vocational ...

  16. Pathways through Secondary School in a Comprehensive System: Does Parental Education and School Attended Affect Students' Choice?

    Science.gov (United States)

    Chesters, Jenny

    2015-01-01

    As the Australian labour market restructured during the 1980s and 1990s, Year 12 retention rates more than doubled between 1983 and 1993 secondary schools diversified to include vocational education and training programs as alternative pathways through school. From a human capital perspective, the completion of vocational qualifications in school…

  17. Research Progress on Capsaicinoids Biosynthetic Pathway and Its Related Genes%辣椒素类物质生物合成途径及其相关基因研究进展

    Institute of Scientific and Technical Information of China (English)

    吴智明; 程蛟文; 唐鑫; 胡开林

    2012-01-01

    辣椒素类物质是辣椒果实胎座中产生的特异辣味代谢产物的总称.辣椒素类物质在辣椒果实中的生物合成主要有两条途径:以苯丙氨酸为前体的苯丙烷途径和以缬氨酸或亮氨酸为前体的支链脂肪酸途径.本文综述了近年来国内外学者在辣椒素类物质生物合成过程中的主要酶类基因的克隆、基因表达调控机制研究方面取得的最新进展.%Capsaicinoids are the substances responsible for the pungent sensation that synthesize and accumulate unique in fruits placental tissues of Capsicum species. Capsaicinoids are biosynthesized through 2 pathways: phenylpropanoid and branched-chain fatty acid pathways, which provide the precursors phenylalanine and valine or leucine, respectively. This paper reviewed the new research progress on studying the enzymes and genes participating in the biosynthetic pathway and the regulatory process that accounts for different accumulation levels of capsaicinoids in chili pepper fruits.

  18. Reforming Vocational Education and Training

    DEFF Research Database (Denmark)

    Friche, Nanna; Kondrup, Sissel

    The systems of vocational education and training are facing a number of challenges in many European countries. The share of young people who are neither employed, nor in education or training (NEET) is still higher for graduates from upper secondary VET than from upper secondary general programmes....... Students who enter vocational programmes are less likely to graduate than those who are enrolled in general programmes. Moreover, they are nearly five times less likely to enrol in further education than graduates from general secondary schools with similar proficiency in literacy (OECD 2015). These trends...... means that the challenges are twofold. First, the VET systems are required to offer double qualifications, which give access not only to skilled employment, but also to higher education (Deissinger et.al 2013). Secondly, the VET systems are met by diverse demands to be social inclusive and exclusive...

  19. An overview of the social image of Vocational Education: a path towards its appreciation

    Directory of Open Access Journals (Sweden)

    Enrique García Jiménez

    2015-12-01

    Full Text Available Historically, Vocational Education in Spain has suffered a situation of political oversight that, unlike other industrialized countries, it has been conferred a social discredit that is reflected in the lower levels of enrollment in these teachings, traditionally considered "second class" in comparison to university studies. While it is true, it has been developed in recent decades political initiatives to prestige Vocational Education. We point out, hence, what these initiatives are and characteristics of these teachings which, together with the current economic and social situation have helped to positively transform their social image and, therefore, have contributed to a significant increase in enrollment. Also, in this paper the results of an investigation is presented that allow to think that this evolution of the social image of Vocational Educationis perceived by teachers that, as we shall see, consider that it has made good progress in the dignity of these teachings.

  20. Returns on vocational education over the life cycle: Between immediate labour market preparation and lifelong employability

    Science.gov (United States)

    Lavrijsen, Jeroen; Nicaise, Ides

    2017-03-01

    An important issue in the design of secondary-level education is the balance between conveying general and occupation-specific (vocational) skills. On the one hand, vocationally oriented programmes, providing occupation-specific skills with immediate labour market relevance, have repeatedly been shown to secure safe pathways into employment. On the other hand, these programmes tend to put less emphasis on developing general knowledge, skills and competencies, including numeracy and literacy, which are foundational to lifelong learning. Hence, when the needs of the labour market change, employees who opted for a vocational track when they were at secondary school risk being less flexible in adapting to such changes later in their career. The authors of this article examine whether this results in a trade-off between short-term gains and long-term losses by considering differences in the labour market careers of vocationally and generally educated respondents in the 2012 Programme for the International Assessment of Adult Competencies (PIAAC). Their results suggest that early labour market benefits of vocational specialisation decrease over time; the authors relate this to its lower ability to equip secondary school students - future employees - with skills for lifelong learning.

  1. Returns on vocational education over the life cycle: Between immediate labour market preparation and lifelong employability

    Science.gov (United States)

    Lavrijsen, Jeroen; Nicaise, Ides

    2017-04-01

    An important issue in the design of secondary-level education is the balance between conveying general and occupation-specific (vocational) skills. On the one hand, vocationally oriented programmes, providing occupation-specific skills with immediate labour market relevance, have repeatedly been shown to secure safe pathways into employment. On the other hand, these programmes tend to put less emphasis on developing general knowledge, skills and competencies, including numeracy and literacy, which are foundational to lifelong learning. Hence, when the needs of the labour market change, employees who opted for a vocational track when they were at secondary school risk being less flexible in adapting to such changes later in their career. The authors of this article examine whether this results in a trade-off between short-term gains and long-term losses by considering differences in the labour market careers of vocationally and generally educated respondents in the 2012 Programme for the International Assessment of Adult Competencies (PIAAC). Their results suggest that early labour market benefits of vocational specialisation decrease over time; the authors relate this to its lower ability to equip secondary school students - future employees - with skills for lifelong learning.

  2. Progress in visual processing pathways in compound eyes of bees%蜜蜂复眼的视觉通路研究进展

    Institute of Scientific and Technical Information of China (English)

    赵慧霞; 郑火青; 胡福良

    2012-01-01

    视觉通路的研究在神经科学、仿生应用和医学治疗上都具有十分重要的意义.西方蜜蜂Apis mellifera作为神经生物学研究的重要模式生物已被广泛地应用于视觉通路的研究.蜜蜂的视觉器官包括1对复眼和3只单眼,复眼是形成视觉的主要感觉器官.视叶是蜜蜂传递和处理视觉信息的主要神经构造,它包括视神经节层、视髓质层、视小叶和前视结节4个等级的神经纤维网.复杂的视觉信息在经过大脑的各级神经时被分离,以许多空间隔离的并行连续的视觉通路传递和加工,然后汇集到高级脑中枢,部分甚至与其他感觉模态的信息相整合,最终输出有效信息来调控蜜蜂的各种行为.本文按照信息在视叶中逐级传递的顺序对蜜蜂复眼的视觉通路研究进展进行综述.%Research on the visual processing pathways is of great significance in neuroscience, bionic applications and medical treatments. The western honeybee, Apis mellifera, as an important model organism for neurobiology research, has been extensively applied to the research on visual processing pathways. The visual organs of bees include a pair of compound eyes and three ocelli, in which the compound eyes are most important for vision formation. In bees, processing of visual information is achieved within the optic lobes which are divided into four levels of neuropils, i. e., lamina, medulla, lobula and anterior optic tubercle. Complex visual information is segregated at successive stages within the brain, and processed in many parallel and sequential visual pathways. Then they are converged in higher-order brain centers, with some integrated with information of other modalities, which finally generate effective outputs to regulate and control bee behaviours. In this article, the research on visual processing pathways in bee compound eyes is reviewed according to the sequence of information processing in the optic lobes.

  3. Use of international data sets to evaluate and validate pathway assessment models applicable to exposure and dose reconstruction at DOE facilities. Progress report, August 1993--January 1994

    Energy Technology Data Exchange (ETDEWEB)

    Hendrickson, S.M. [ed.] [Lawrence Livermore National Lab., CA (United States); Hoffman, F.O. [Senes Oak Ridge, Inc., TN (United States). Center for Risk Analysis

    1994-03-01

    This project, ``Use of International Data Sets to Evaluate and Validate Pathway Assessment Models Applicable to Exposure and Dose Reconstruction at DOE Facilities,`` grew out of several activities being conducted by the Principal Investigator Dr. F Owen Hoffman. One activity was originally part of the Chernobyl Studies Project and began as Task 7.1D, ``Internal Dose From Direct Contamination of Terrestrial Food Sources.`` The objective of Task 7.1D was to (1) establish a collaborative US USSR effort to improve and validate our methods of forecasting doses and dose commitments from the direct contamination of food sources, and (2) perform experiments and validation studies to improve our ability to predict rapidly and accurately the long-term internal dose from the contamination of agricultural soil. The latter was to include the consideration of remedial measures to block contamination of food grown on contaminated soil. The current objective of this project is to evaluate and validate pathway-assessment models applicable to exposure and dose reconstruction at DOE facilities through use of international data sets. This project incorporates the activity of Task 7.1D into a multinational effort to evaluate data used for the prediction of radionuclide transfer through agricultural and aquatic systems to humans. It also includes participation in two multinational studies, BIOMOVS (BIOspheric MOdel Validation Study) with the Swedish National Institute for Radiation Protection and VAMP (VAlidation of Model Predictions) with the International Atomic Energy Agency, that address testing the performance of models of radionuclide transport through foodchains.

  4. Research Progress of RANK/RANKL/OPG Signaling Pathway%RANK/RANKL/OPG信号通路的研究进展

    Institute of Scientific and Technical Information of China (English)

    王琰; 刘超; 宋仁纲

    2013-01-01

    核因子κB受体活化因子/核因子κB受体活化因子配体/骨保护素(RANK/RANKL/OPG)信号通路是近些年来骨代谢领域的重大发现.许多激素、细胞因子、生长因子通过作用于核因子κB受体活化因子配体,骨保护素影响骨代谢,而导致骨代谢疾病如骨质疏松,溶骨性骨肿瘤及恶性肿瘤骨转移等.该文就主要RANK/RANKL/OPG信号通路的成员、信号转导及表达调控进行综述.%The RANK/RANKL/OPG signaling pathway is an important discovery of bone metabolism in recent years. A lot of hormones, cytokines, growth factors influence bone metabolism by acting on receptor activator of NF-k B ligand( RANKL )and osteoprotegerin( OPG ),which lead to metabolic bone diseases such as osteoporosis,osteolytic bone tumors and malignant tumor bone metastasis. Here is to make a review on the member,signal transduction and regulation of expression of RANK/RANKL/OPG signaling pathway.

  5. Putting a Vocational Focus Back into Rehabilitation

    Science.gov (United States)

    Murphy, Gregory C.

    2009-01-01

    Traditionally, rehabilitation has been closely associated with vocational potential and return to work post-injury, or the maintenance of work attendance following the onset of chronic disease. Indeed, so close was the association that the terms "rehabilitation" and "vocational rehabilitation" were virtually synonymous. Over…

  6. Applying a Typology to Vocational Aspirations.

    Science.gov (United States)

    Holland, John L.; Gottfredson, Gary D.

    The psychological meaning and predictive value of a person's vocational aspirations were examined by applying Holland's typology to the vocational aspirations of high school juniors (N=1,005), college juniors (N=692), employed adults (N=140), and a second sample of college students studied over a 1 year interval (N=624). The aspirational data were…

  7. Vocational Indecision: More Evidence and Speculation

    Science.gov (United States)

    Holland, John L.; Holland, Joan E.

    1977-01-01

    Samples of 1,005 high school juniors and 692 college juniors were assessed with measures of personality, decision-making ability, interests, and vocational attitude. Comparisons of undecided and decided students indicate they are alike on most measures, but substantial and significant differences were found for the Identity and Vocational Attitude…

  8. Data Available for Studying Vocational Education.

    Science.gov (United States)

    Orr, David B.

    The Vocational Education Data System (VEDS) data base was created as a result of the Vocational Education Amendments of 1976. VEDS statistics were to be collected in the form of state-aggregate data (that is, state-level data is submitted by each state, based upon records and data collected by the state for this and other purposes); and VEDS data,…

  9. Vocational Teaching Cube System of Engineering Graphics

    Institute of Scientific and Technical Information of China (English)

    YangDaofu; LiuShenli

    2003-01-01

    Based on long-time research on vocational teaching cube theory in graphics education and analyzing on the intellectual structure in the process of reading engineering drawing, the graphics intellectual three-dimensional model, which is made up of 100 cubes, is founded and tested in higher vocational graphics education. This system serves as a good guidance to the graphics teaching.

  10. Hispanic Vocational Exploration Project. Final Report.

    Science.gov (United States)

    Centro De La Comunidad, Inc., New London, CT.

    During its second year, the Hispanic Vocational Exploration Project recruited eighth and ninth grade Hispanic youth for a four-week cycle, after-school, career exploratory program at Southeastern Regional Vocational Technical School, Groton, Connecticut. A series of career education workshops was the other major project activity. Supportive…

  11. The Structure of Vocational Interests in Romania

    Science.gov (United States)

    Iliescu, Dragos; Ispas, Dan; Ilie, Alexandra; Ion, Andrei

    2013-01-01

    Using data provided by the Self-Directed Search (SDS) on a sample of 1,519 participants comprising 3 subsamples containing high school students, university students, and working adults, the authors examine the structure of vocational interests in Romania. Three competing structural models of vocational interests (Holland's circumplex model and…

  12. Vocational Preparation Teacher Manual. Missouri LINC.

    Science.gov (United States)

    Wallace, Steve; And Others

    This document defines the role and responsibilities of Missouri's vocational preparation teachers as they work with disadvantaged and handicapped students in vocational education programs and offers advice on how they can fulfill their role and responsibilities. Following the introduction is the questionnaire used in a survey of vocational…

  13. Bringing Realism Into the Vocational Typing Course

    Science.gov (United States)

    Lloyd, Alan C.

    1978-01-01

    Based on "Typing 2," Gregg's new second-year vocational typing book for high schools, this article discusses ways to use the textbook and what the teacher can do to support the spirit of realism, purpose, and efficiency that the author feels should dominate the vocational typing course. (TA)

  14. Gasoline Engine Mechanics. Florida Vocational Program Guide.

    Science.gov (United States)

    University of South Florida, Tampa. Dept. of Adult and Vocational Education.

    This vocational program guide is intended to assist in the organization, operation, and evaluation of a program in gasoline engine mechanics in school districts, area vocational centers, and community colleges. The following topics are covered: job duties of small-engine mechanics; program content (curriculum framework and student performance…

  15. Fashion Marketing. Florida Vocational Program Guide.

    Science.gov (United States)

    Florida State Univ., Tallahassee. Center for Instructional Development and Services.

    This vocational program guide is intended to assist in the organization, operation, and evaluation of a program in fashion marketing in school districts, area vocational centers, and community colleges. The following topics are covered: program content (job duties of wholesale and retail clothing salespersons and curriculum framework and student…

  16. Leadership Skills among Technical and Vocational Educators

    Science.gov (United States)

    Zakaria, Nurazyan Zahidah; Jizat, Nor Atikah Md.; Zakaria, Normah

    2015-01-01

    The purpose of leadership skills among technical and vocational educator are to prepare them towards effective organization. Effective leadership is widely accepted as being a key constituent in achieving organization improvement and to examine. This study aimed to gauge the leadership skills among technical and vocational educators effectiveness…

  17. Anomie and Vocational-Technical Education

    Science.gov (United States)

    Anthony, William P.; Miljus, Robert C.

    1973-01-01

    Graduates from a public, postsecondary vocational-technical school are compared with a control group to assess differences in level of anomie. While differences in some cases were minimal, vocational-technical graduates generally revealed more positive attitudes. It is suggested that since their education is more job-centered and they have…

  18. IVA. Improving Vocational Administration. Final Report.

    Science.gov (United States)

    EPD Consortium D, Richardson, TX.

    The Texas Improving Vocational Administration (IVA) project was conceived to improve preservice and inservice programs for vocational education administrators. Primary objectives were to (1) develop a method, including a survey, to determine existing inservice and preservice administrative training program competencies; (2) determine, using the…

  19. Vocational Teachers' Identity Formation through Boundary Crossing

    Science.gov (United States)

    Fejes, Andreas; Köpsén, Susanne

    2014-01-01

    Vocational teachers' prior occupational experiences are construed as those that will guarantee high-quality teaching in vocational education, although individuals are no longer required to have formal teaching qualifications to be employed as teachers in Sweden. This lack of strict requirements raises the issue of the preparedness of vocational…

  20. Vocational Teachers between Educational Institutions and Workplaces

    Science.gov (United States)

    Isopahkala-Bouret, Ulpukka

    2010-01-01

    The aim of this study is to analyze discursively how the relationship between educational institutions and workplaces materializes in the position of a vocational teacher. Several studies have pointed out that the role of vocational teachers is changing as a result of current educational reforms, which can be understood in terms of bringing…

  1. Chinese Vocational Education: Borrowing and Reforming

    Science.gov (United States)

    Wang, Lei; Jiang, Dayuan

    2013-01-01

    In July 2010 in Beijing, Lei Wang interviewed Professor Dayuan Jiang, Research Fellow at the Ministry of Education's Central Institute for Vocational and Technical Education about how China has drawn from foreign vocational education models and China's own innovation process. Jiang pointed out that Germany's educational philosophy and talent…

  2. Anomie and Vocational-Technical Education

    Science.gov (United States)

    Anthony, William P.; Miljus, Robert C.

    1973-01-01

    Graduates from a public, postsecondary vocational-technical school are compared with a control group to assess differences in level of anomie. While differences in some cases were minimal, vocational-technical graduates generally revealed more positive attitudes. It is suggested that since their education is more job-centered and they have…

  3. Vocation in Theology and Psychology: Conflicting Approaches?

    Science.gov (United States)

    Rotman, Marco

    2017-01-01

    Recent contributions in the fields of psychology, sociology, and theology reveal opposing attitudes about the subject of calling or vocation with regard to one's work. Whereas psychologists have rediscovered the concept, theologians increasingly show reluctance to accept a vocational view of work. In offering an alternative perspective, this…

  4. IVA. Improving Vocational Administration. Final Report.

    Science.gov (United States)

    EPD Consortium D, Richardson, TX.

    The Texas Improving Vocational Administration (IVA) project was conceived to improve preservice and inservice programs for vocational education administrators. Primary objectives were to (1) develop a method, including a survey, to determine existing inservice and preservice administrative training program competencies; (2) determine, using the…

  5. A Social Neuroscientific Model of Vocational Behavior

    Science.gov (United States)

    Hansen, Jo-Ida C.; Sullivan, Brandon A.; Luciana, Monica

    2011-01-01

    In this article, the separate literatures of a neurobiologically based approach system and vocational interests are reviewed and integrated into a social neuroscientific model of the processes underlying interests, based upon the idea of selective approach motivation. The authors propose that vocational interests describe the types of stimuli that…

  6. 20 CFR 638.503 - Vocational training.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Vocational training. 638.503 Section 638.503 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR JOB CORPS PROGRAM UNDER TITLE IV-B OF THE JOB TRAINING PARTNERSHIP ACT Center Operations § 638.503 Vocational training. (a)...

  7. Vocations: The Link between Post-Compulsory Education and the Labour Market. What the Research Says For... Tertiary Education Providers & School Educators

    Science.gov (United States)

    Wheelahan, Leesa; Buchanan, John; Yu, Serena

    2015-01-01

    This summary brings together the relevant key findings for tertiary education providers and school educators from the research program "Vocations: The Link between Post-Compulsory Education and the Labour Market." The program was comprised of three different strands: (1) pathways from VET in Schools, (2) pathways within and between…

  8. 20 CFR 725.710 - Objective of vocational rehabilitation.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Objective of vocational rehabilitation. 725... OF THE FEDERAL MINE SAFETY AND HEALTH ACT, AS AMENDED Medical Benefits and Vocational Rehabilitation § 725.710 Objective of vocational rehabilitation. The objective of vocational rehabilitation is...

  9. Some Practical Remedies for Providing Vocational Guidance for Everyone.

    Science.gov (United States)

    Holland, John L.

    After describing some current problems in vocational guidance and summarizing relevant knowledge and theory in the field, this paper presents some practical plans, materials, and ideas for providing more useful vocational assistance to people of all ages. The paper reviews such prominent vocational guidance approaches as vocational information and…

  10. Progress in studying on pyroptosis-related signaling pathway in heart diseases%焦亡在心脏疾病中的研究进展

    Institute of Scientific and Technical Information of China (English)

    郑嘉; 秦颖; 高硕阳; 蒋雅楠; 陈阳; 王燕

    2016-01-01

    焦亡是一种新发现并证实与炎症相关的细胞死亡方式,其特征为依赖于半胱天冬氨酸蛋白酶-1(cysteinyl aspartate specific proteinase-1,Caspase-1)的细胞程序性死亡,并伴有促炎症因子的释放,主要为白介素-1β(interleukin-1β,IL-1β)和白介素-18(interleukin-18,IL-18).越来越多的研究发现,焦亡相关信号通路在心脏疾病中起重要作用,包括心肌梗死、缺血再灌注损伤、心肌肥厚、心肌纤维化和心力衰竭等.本文就焦亡相关信号通路与心脏疾病关系研究进展作一综述.%Pyroptosis is a newly discovered and defined inflammation-related cell death,it is characterized by cysteinyl aspartate specific proteinase-1 (caspase-1)-depended programmed cell death which is a accompanied with the release of pro-inflammatory cytokines,mainly interleukin-1β (IL-1β) and IL-18.Increasing evidences suggest that pyroptosis-related signaling pathway plays important roles in myocardial infarction,ischemia/reperfusion,myocardial hypertrophy,myocardial fibrosis and heart failure,etc.This paper reviews the current understandings of pyroptosis-related signaling pathway in heart diseases.

  11. Hands-on creativity in Vocational Education

    DEFF Research Database (Denmark)

    Tanggaard, Lene

    This presentation poses the question: what conception of the phenomenon of creativity is best suited to the field of vocational education? VET (Vocational Education and Training) aims to prepare people for employment in craft and industry. In this field, there is an ever-growing requirement...... for creativity and innovation. In response, it is my concern that an understanding of creativity be developed with vocational education and training in mind. It is not enough to import models from other areas, where the distinction between ideas and production or creativity and execution is often relatively hazy...... and therefore not well suited for VET comprising production, handcraft and industry. In Europe, vocational education schemes are considered the solid base on which almost all kinds of industry and craft depend. If Europe is to retain its innovative capacity, then vocational education, especially the capacity...

  12. The Effects of Vocational Training on Labor Force Experience. An Analysis of the Tennessee Area Vocational Technical School System.

    Science.gov (United States)

    Schriver, William R.; Bowlby, Roger L.

    To analyze the differential benefits from vocational training, a study was made involving 1,701 former students selected at random from 19 area vocational-technical schools in Tennessee. Major objectives of the study were to determine: (1) economic justification of vocational training, (2) wage differences among the vocationally trained and…

  13. Students' Meaning-Making and Sense-Making of Vocational Knowledge in Dutch Senior Secondary Vocational Education

    Science.gov (United States)

    Bijlsma, Nienke; Schaap, Harmen; de Bruijn, Elly

    2016-01-01

    Meaning-making and sense-making are generally assumed to be part of students' personal vocational knowledge development, since they contribute to both students' socialisation in a vocation and students' personalisation of concepts, values and beliefs regarding that vocation. However, how students in vocational education acquire meaning and make…

  14. The research progress of the ATM-dependent signaling pathways%ATM蛋白激酶依赖性信号转导通路研究进展

    Institute of Scientific and Technical Information of China (English)

    刘小群; 陈伟; 袁素娟

    2012-01-01

    Mutations in the ataxia-telangiectasia mutated gene (ATM gene) lead to the genetic disorder ataxia-telangiectasia (A-T). The ATM protein kinase, which is the product of the ATM gene, is mainly distributed in the nucleus of proliferating cells. Here we clarify the ATM-dependent signaling pathways according to phosphorylating various targets that include checkpoint kinase 2 (Chk2) , Nijmegen breakage syndrome protein 1 (Nbs1) and p38 mitogen activated protein kinase (p38MAPK) at different stages of the cell cycle. Recent studies reveal that the ATM-dependent signaling pathways involve in regulating multiple cell cycle checkpoints and play vital roles in repairing DNA double-strand breaks (DSBs) in the cell cycle, suggesting that the ATM kinase perhaps is a new target for radiosensitization in the radiotherapy of malignant neoplasms.%毛细血管扩张共济失调突变基因(ataxia-telangiectasia mutated gene,ATM基因)变异导致遗传性毛细血管扩张共济失调症(ataxia-telangiectasia,A-T).ATM基因编码产物——ATM蛋白激酶主要分布于增殖细胞核中.根据ATM蛋白激酶在细胞周期中作用底物如检测点激酶2(checkpoint kinase 2,Chk2)、奈梅亨断裂综合症蛋白1 (Nijmegen breakage syndrome protein 1,Nbs1)和p38丝裂原活化蛋白激酶(p38 mitogen activated protein kinase,p38MAPK)等不同,形成了不同的ATM蛋白激酶依赖性信号转导通路.最近研究发现,ATM蛋白激酶依赖性信号转导通路参与细胞周期多个检测点的调控,在DNA双链断裂(DNA double-strand break,DSB)损伤修复过程中发挥着至关重要的作用,暗示了ATM蛋白激酶或将成为恶性肿瘤放射治疗增敏新靶点.

  15. Research progress of Notch signaling pathway in hepatocellular carcinoma%Notch信号通路在肝癌中的研究进展

    Institute of Scientific and Technical Information of China (English)

    祝普利; 王德盛; 周亮; 苟泽鹏; 窦科峰

    2012-01-01

    Notch信号通路存在于多种动物体内,其家族成员的结构具有高度保守性,在细胞分化和发育中发挥着关键作用,保持着细胞增殖、分化和凋亡三者之间的动态平衡.异常活化的Notch信号可促使正常细胞向恶性转化,失控的Notch信号与肿瘤细胞的生长相关,Notch信号在大多数情况下作为癌基因促进肿瘤生长,但也发挥着诱导细胞分化、抑制肿瘤细胞增殖的作用.%The Notch signaling pathways exist in many animals, the members of the family structure is highly conservative. It plays a key role in cell differentiation and development and maintains the balance between cell proliferation, differentiation and apoptosis. The abnormal activation of Notch signal can contribute to normal to malignant transformation, and uncontrolled Notch signaling which is related to the growth of tumor cells regulation. Notch signal often acts as cancer gene to promote tumor growth in most of cases, but can also lead to cell differentiation and inhibit tumor proliferation role.

  16. Disruption of structural connectivity along the dorsal and ventral language pathways in patients with nonfluent and semantic variant primary progressive aphasia: a DT MRI study and a literature review.

    Science.gov (United States)

    Agosta, Federica; Galantucci, Sebastiano; Canu, Elisa; Cappa, Stefano F; Magnani, Giuseppe; Franceschi, Massimo; Falini, Andrea; Comi, Giancarlo; Filippi, Massimo

    2013-11-01

    Nonfluent (NFV) and semantic (SV) variants of primary progressive aphasia (PPA) are associated with distinct patterns of focal cortical atrophy and underlying pathology. Previous diffusion tensor (DT) MRI studies showed a more ventral white matter (WM) involvement in SV patients and a more widespread frontal involvement in NFV. Aim of this manuscript is twofold. First, we wished to provide a brief state-of-the-art review on WM damage in PPA. Second, we used DT MRI to assess the topography of WM microstructural damage along dorsal and ventral language pathways and corpus callosum in patients with NFV and SV. Our findings show that the two PPA variants share an overlapping pattern of dorsal and ventral pathway abnormalities. In addition to these common abnormalities, variant-specific WM changes were also found, with NFV patients having a more severe damage to the dorsal (fronto-parietal) WM connections within the left superior longitudinal fasciculus/arcuate and SV patients showing a greater left ventral tract involvement (inferior longitudinal and uncinate fasciculi). These findings offer evidence that both dorsal and ventral language networks may contribute to the relatively selective deficits in NFV and SV patients.

  17. Wogonoside prevents colitis-associated colorectal carcinogenesis and colon cancer progression in inflammation-related microenvironment via inhibiting NF-κB activation through PI3K/Akt pathway

    Science.gov (United States)

    Wang, Xiaoping; Zhao, Li; Li, Wenjun; Ding, Youxiang; Kong, Lingyi; Guo, Qinglong; Lu, Na

    2016-01-01

    The inflammatory microenvironment has been reported to be correlated with tumor initiation and malignant development. In the previous studies we have found that wogonoside exerts anti-neoplastic and anti-inflammatory activities. In this study, we aimed to further investigate the chemopreventive effects of wogonoside on colitis-associated cancer and delineated the potential mechanisms. In the azoxymethane initiated and dextran sulfate sodium (AOM/DSS) promoted colorectal carcinogenesis mouse model, wogonoside significantly reduced the disease severity, lowered tumor incidence and inhibited the development of colorectal adenomas. Moreover, wogonoside inhibited inflammatory cells infiltration and cancer cell proliferation at tumor site. Furthermore, wogonoside dramatically decreased the secretion and expression of IL-1β, IL-6 and TNF-α as well as the nuclear expression of NF-κB in adenomas and surrounding tissues. In vitro results showed that wogonoside suppressed the proliferation of human colon cancer cells in the inflammatory microenvironment. Mechanistically, we found that wogonoside inhibited NF-κB activation via PI3K/Akt pathway. In conclusion, our results demonstrated that wogonoside attenuated colitis-associated tumorigenesis in mice and inhibited the progression of human colon cancer in inflammation-related microenvironment via suppressing NF-κB activation by PI3K/Akt pathway, indicating that wogonoside could be a promising therapeutic agent for colorectal cancer. PMID:27102438

  18. Progress in the Study of Cell Signaling Pathway Associated with Paraquat Poisoning%细胞信号通路与百草枯中毒的研究进展

    Institute of Scientific and Technical Information of China (English)

    张志坚; 田黎

    2012-01-01

    Paraquat is a kind of herbicides widely used in agricultural production, which possesses strong toxicity and injures the body through producing multiple free radicals by oxidation-reduction reaction, especially the lung. Recently, researches concerning effects of paraquat on cell signal pathway and body have made great progress. Here is to make a review' on the latest researches concerning effects of paraquat on mito-gen activating protein kinase, nuclear factor-KB , TGF-β/Smad pathway activation, and relationship of paraquat with cell cycle and apoptosis.%百草枯是农业生产中广泛使用的一种除草剂,有较强的毒性,主要通过一系列的氧化还原反应产生多种自由基造成对机体严重的损害,尤其是对肺脏的损害最为严重.近年来,百草枯对细胞信号通路的影响及其对机体影响的研究已取得了较大进展.现就百草枯对丝裂素活化蛋白激酶信号通路、核因子κB信号通路、转化生长因子β/Smad通路等的影响及其与细胞周期和细胞凋亡的关系进行综述.

  19. Research Progress of mTOR Signaling Pathway in Spinal Cord Injury%mTOR信号通路在脊髓损伤中的研究进展

    Institute of Scientific and Technical Information of China (English)

    孔祥龙

    2012-01-01

    哺乳动物雷帕霉素靶蛋白(Mammalian target of rapamycin,mTOR)信号通路在细胞代谢,增殖与存活,血管生成,延缓细胞衰老中发挥着关键作用.另外,mTOR信号通路在各种中枢神经系统疾病和中枢神经系统创伤及修复中起着非常关键的作用.近年来,mTOR信号通路相关抑制药物相继问世,并在免疫抑制和抗肿瘤方面取得了一定的临床疗效.mTOR信号通路的细胞分子机制已成为研究热点.本文就调节mTOR信号通路在脊髓损伤中产生神经保护、神经再生效应的研究进展进行综述.%The mammalian target or rapamycin (mTOR) signaling pathway plays an important role in multiple cellular functions, such as cell metabolism, proliferation and survival. Many previous studies have shown that mTOR regulates both neuron-protective and neuron-regenerative functions in trauma and various diseases in the central nervous system. In recent years, the inhibitors of mTOR signaling pathway have been developed in succession, which have exhibited definite clinical effects on both immunosuppressive and tumor suppressive. As a result, further research on this pathway and its mechanisms in various diseases have become one of the hot research areas. This paper reviews the research progress of mTOR in spinal cord injury.

  20. Nrf2/ARE转导通路在中枢神经系统疾病中作用的研究进展%Progress in Research on Role of Nrf2/ARE Transduction Pathway in Central Nervous System Diseases

    Institute of Scientific and Technical Information of China (English)

    朱凤臣

    2011-01-01

    转录因子红细胞系-2p45相关因子2(Nuclear factor erythroid-2p45-related factor 2,Nrf2)是细胞调节抗氧化应激反应的重要转录因子,其与抗氧化反应元件(Antioxidant response element,ARE)结合,调控第Ⅱ相解毒酶及抗氧化酶基因的表达,是机体抵抗内外氧化应激的关键保护性通路.中枢神经系统氧耗高,多不饱和脂肪酸含量丰富,对氧化应激极为敏感,Nrf2/ARE转导通路在中枢神经系统中作用的研究越来越受到重视.本文对Nrfd2/ARE转导通路的调控机制及其在中枢神经系统疾病中作用的最新研究进展作一综述.%Nuclear factor erythroid-2p45-related factor 2 (Nrf2)is an important transcription factor for cells to mediate the resistance to oxidative stress. As a pivotal protective pathway to resist internal and external oxidative stress, it binds to antioxidant response element (ARE) and regulates the expressions of phase Ⅱ detoxification enzyme genes and antioxidant enzyme genes. With high oxygen consumption and abundant polyunsaturated fatty acids, central nervous system is sensitive to oxidative stress. The role of Nrf2/ARE transduction pathway in the central nervous system is paid more and more attentions. This article summarizes the latest progress in research on regulatory mechanisms of Nrf2/ARE transduction pathway as well as its role in central nervous system diseases.

  1. Wnt和Notch信号通路在肺癌干细胞调控中的研究进展%The Research Progress of Wnt and Notch Pathways in the Regulation of Lung Cancer Stem Cells

    Institute of Scientific and Technical Information of China (English)

    况里杉; 罗虎

    2013-01-01

    Cancer stem cells which have self-renewal and multi-directional differentiation potential are a small number of undifferentiated cell group and they play an important role in the development and progression of human tumors. The lung cancer stem cells were thought to be the root of lung cancer with renewal, differentiation, metastasis and tumorigenesis capacity. Recent researches indicate that lung cancer stem cells are under the co-regulation of the inside genes themselves and the microenvironmental signals around them. Wnt and Notch signal pathways which are two classic development regulation pathways play important roles in them. The profound research on Wnt and Notch signal pathways in the regulation of lung cancer stem cells is beneficial to the discovery of potential targets for the treatment and diagnosis of lung cancer.%肿瘤干细胞是具有自我更新和多向分化潜能的少部分未分化细胞,在多种肿瘤的发生、发展中发挥重要作用.肺癌干细胞被认为是肺癌发生的根源,具有自我更新、分化、转移、致瘤性等特征.已有研究表明,肺癌干细胞受自身内在基因和其所处微环境信号的共同调控,两条经典的发育调控通路Wnt、Notch在其中发挥重要作用.深入研究Wnt和Notch信号通路在肺癌干细胞调控中的作用,有望在肺癌的诊断及治疗中找到新靶点.

  2. Moderate Autophagy Inhibits Vascular Smooth Muscle Cell Senescence to Stabilize Progressed Atherosclerotic Plaque via the mTORC1/ULK1/ATG13 Signal Pathway

    Directory of Open Access Journals (Sweden)

    Zhenli Luo

    2017-01-01

    Full Text Available In order to investigate the effects of autophagy induced by rapamycin in the development of atherosclerosis plaque we established murine atherosclerosis model which was induced in ApoE−/− mice by high fat and cholesterol diet (HFD for 16 weeks. Rapamycin and 3-Methyladenine (MA were used as autophagy inducer and inhibitor respectively. The plaque areas in aortic artery were detected with HE and Oil Red O staining. Immunohistochemical staining were applied to investigate content of plaque respectively. In contrast to control and 3-MA groups, rapamycin could inhibit atherosclerosis progression. Rapamycin was able to increase collagen content and a-SMA distribution relatively, as well as decrease necrotic core area. Then we used MOVAS and culture with ox-LDL for 72 h to induce smooth muscle-derived foam cell model in vitro. Rapamycin and 3-MA were cultured together respectively. Flow cytometry assay and SA-β-Gal staining experiments were performed to detect survival and senescence of VSMCs. Western blot analysis were utilized to analyze the levels of protein expression. We found that rapamycin could promote ox-LDL-induced VSMCs autophagy survival and alleviate cellular senescence, in comparison to control and 3-MA groups. Western blot analysis showed that rapamycin could upregulate ULK1, ATG13 and downregulate mTORC1 and p53 protein expression.

  3. MiR-21 inhibitor suppressed the progression of retinoblastoma via the modulation of PTEN/PI3K/AKT pathway.

    Science.gov (United States)

    Gui, Fu; Hong, Zhengdong; You, Zhipeng; Wu, Hongxi; Zhang, Yulan

    2016-12-01

    MicroRNA-21 (miR-21) was reported to act as an oncogene during the development of many human tumors. However, little was revealed about the function of miR-21 in retinoblastoma (RB). In this study, we examined the expression of miR-21 in RB tissues and explored the relationship between miR-21 and phosphatase and tensin homolog (PTEN)/phosphatidylinositol-3-OH kinase (PI3K)/AKT signal. Quantitative real-time PCR (qRT-PCR) results showed that the level of miR-21 in RB tissues was higher than that in retinal normal tissues. In Weri-Rb-1 cells, miR-21 inhibitor suppressed the expression of miR-21 and cell viability, but improved cell apoptotic rates by modulating the levels of PDCD4, Bax, and Bcl-2. Meanwhile, miR-21 inhibitor suppressed cell migration and invasion via inhibiting the protein levels of MMP2 and MMP9 and significantly affected the expression of PTEN, PI3K, and p-AKT. Taken together, miR-21 inhibitor suppressed cell proliferation, migration, and invasion via the PTEN/PI3K/AKT signal. These findings revealed the molecular basis of miR-21 functioning in the progression of RB and provided a new means for cell therapy in RB.

  4. Notch信号通路与乳腺癌的研究进展%Progress of Notch Signaling Pathway in Breast Cancer

    Institute of Scientific and Technical Information of China (English)

    刘宇; 徐海帆

    2014-01-01

    Notch信号通路是一条进化过程中高度保守的信号通路,广泛存在于生物进化过程中,是决定细胞命运的重要通路之一,相邻细胞通过Notch受体与配体相互作用转导细胞信号,在细胞的增值、分化及凋亡过程中发挥重要的调控作用。Notch信号通路的异常激活与乳腺癌的发生、发展有着密切关系,本文对Notch信号通路及其异常表达与乳腺癌的关系进行综述,重点讲述Notch信号通路与乳腺癌的发病机制,希望能给靶向治疗乳腺癌带来一条新的思路。%During evolution signal patchway, Notch signal patchway is a highiy conserved which is widely exist in organism evolution and is one of the important determine cells fate pathway. Between Notch receptor and ligand interaction transmit adjacent cell signal, which plays an important role in regulating value, differentiation and apoptosis of cells. Notch signal pathway abnormal activation, relationship with of breast cancer. This review Notch signal pathway and abnormal express with breast cancer. This important report Notch signaling pathway in the pathogenesis of breast cancer. I wish bring a new strategy to provide breast cancer targeted  treatment.

  5. The single N-glycan deletion mutant of soluble ErbB3 protein attenuates heregulin β1-induced tumor progression by blocking of the HIF-1 and Nrf2 pathway

    Energy Technology Data Exchange (ETDEWEB)

    Takamiya, Rina, E-mail: rinataka0429@gmail.com; Takahashi, Motoko; Uehara, Yasuaki; Ariki, Shigeru; Hashimoto, Jiro; Hasegawa, Yoshihiro; Kuroki, Yoshio

    2014-11-21

    Highlights: • The sErbB3 N418Q mutant blocks heregulin β1 induced nuclear accumulation of HIF-1α. • The sErbB3 N418Q mutant attenuates cancer cell migration induced by heregulin β1. • The sErbB3 N418Q mutant blocks heregulin β1 induced nuclear accumulation of Nrf2. • The sErbB3 N418Q mutant may be a potential therapeutic application for tumor. - Abstract: It has been well documented that activation of the ErbB3–PI3K–Akt pathway is implicated in tumor survival and progression. We previously demonstrated that the single N-glycan deletion mutant of soluble ErbB3 protein (sErbB3 N418Q) attenuates heregulin β1-induced ErbB3 signaling. The active PI3K–Akt pathway augments the nuclear accumulation of hypoxia inducible factor (HIF)-1α, which activates the transcription of many target genes and drives cancer progression. In this study, we focused on the effects of sErbB3 N418Q mutant on nuclear accumulation of HIF-1α. Pretreatment with the sErbB3 N418Q mutant suppressed heregulin β1-induced HIF-1α activation in MCF7 cells. Similar results were also obtained in other breast cancer cell lines, T47D and BT474. Interestingly, these suppressive effects were not observed with the sErbB3 wild type. In addition, pretreatment with the sErbB3 N418Q mutant suppressed the cell migration of MCF7 cells induced by heregulin β1. Furthermore, incubation with heregulin β1 also induced the nuclear accumulation of Nrf2, and this effect was also reduced by the sErbB3 N418Q mutant, but not the sErbB3 wild type. These findings indicated that the sErbB3 N418Q mutant suppressed malignant formation of cancer cells by blocking of the HIF-1α and Nrf2 pathways.

  6. Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways.

    Directory of Open Access Journals (Sweden)

    Muthu K Shanmugam

    Full Text Available Prostate cancer is one of the leading causes of cancer death among men worldwide. In this study, using transgenic adenocarcinoma of mouse prostate (TRAMP mice, the effect of diet enriched with 1% w/w ursolic acid (UA was investigated to evaluate the stage specific chemopreventive activity against prostate cancer. We found that TRAMP mice fed with UA diet for 8 weeks (weeks 4 to 12 delayed formation of prostate intraepithelial neoplasia (PIN. Similarly, mice fed with UA diet for 6 weeks (weeks 12 to 18 inhibited progression of PIN to adenocarcinoma as determined by hematoxylin and eosin staining. Finally, TRAMP mice fed with UA diet for 12 weeks (weeks 24 to 36 demonstrated markedly reduced tumor growth without any significant effects on total body weight and prolonged overall survival. With respect to the molecular mechanism, we found that UA down-regulated activation of various pro-inflammatory mediators including, NF-κB, STAT3, AKT and IKKα/β phosphorylation in the dorsolateral prostate (DLP tissues that correlated with the reduction in serum levels of TNF-α and IL-6. In addition, UA significantly down-regulated the expression levels of cyclin D1 and COX-2 but up-regulated the levels of caspase-3 as revealed by immunohistochemical analysis of tumor tissue sections. Finally, UA was detected in serum samples obtained from various mice groups fed with enriched diet in nanogram quantity indicating that it is well absorbed in the GI tract. Overall, our findings provide strong evidence that UA can be an excellent agent for both the prevention and treatment of prostate cancer.

  7. Vocational Training in the European Union

    Directory of Open Access Journals (Sweden)

    Mehmet BALCI

    2013-01-01

    Full Text Available European Union requires some standards in all areas. Today, the importance of training qualified individuals which holds an important place in the development of countries increases and certain standards are adopted creating common European Union tools in the field of vocational and technical education. In this study, vocational education and training policies system and the standards adopted by the European Union are discussed. Furthermore, this study was accepted as a European Union project in 2010 and the results obtained from the Leonardo Da Vinci Life Learning European Union project called “Web Based Basic Vocational Training” between the years 2010-2012 were presented. Since the partners of these projects are Turkey, Spain and Germany, the structure of vocational education, institutions of public and private vocational education and the diplomas and certificates entitled after these educations are included. As Turkey is on its way to become a European Union member, a number of advices are presented for Turkey to reach its destination about vocational education standards that European Union has aimed. The purpose of the study is not only to be a guide for the young who want to get professional training in the countries that are European Union members or candidates about how and where to have education opportunities but also to give a chance for trainers and training managers, participating in vocational training, so as to glimpse different practices from different countries and compare these practices between the countries of European Union and their countries. The study is also very important as it has the opportunities for training managers to see if their countries' vocational education is close enough to vocational education in European Union.

  8. The Research on the Status, Rehabilitation, Education, Vocational Development, Social Integration and Support Services Related to Intellectual Disability in China

    Science.gov (United States)

    Wu, Lihui; Qiu, Zhuoying; Wong, Daniel; Hernandez, Lucy Wong; Zhao, Qianlei

    2010-01-01

    Intellectual disability (ID) is a prevalent form of non-progressive cognitive impairment. The objectives of this articles are: to analyze the changes of ID in China, including its definition, prevalence, rehabilitation, education, vocational development, social life and support services; to review and to compare the issues of intellectual…

  9. CCL21/CCR7 promotes G2/M phase progression via the ERK pathway in human non-small cell lung cancer cells.

    Directory of Open Access Journals (Sweden)

    Ying Xu

    Full Text Available C-C chemokine receptor 7 (CCR7 contributes to the survival of certain cancer cell lines, but its role in the proliferation of human non-small cell lung cancer (NSCLC cells remains vague. Proliferation assays performed on A549 and H460 NSCLC cells using Cell Counting Kit-8 indicated that activation of CCR7 by its specific ligand, exogenous chemokine ligand 21 (CCL21, was associated with a significant linear increase in cell proliferation with duration of exposure to CCL21. The CCL21/CCR7 interaction significantly increased the fraction of cells in the G(2/M phase of the cell cycle as measured by flow cytometry. In contrast, CCL21/CCR7 had no significant influence on the G(0/G(1 and S phases. Western blot and real-time PCR indicated that CCL21/CCR7 significantly upregulated expression of cyclin A, cyclin B1, and cyclin-dependent kinase 1 (CDK1, which are related to the G(2/M phase transition. The expression of cyclin D1 and cyclin E, which are related to the G(0/G(1 and G(1/S transitions, was not altered. The CCL21/CCR7 interaction significantly enhanced phosphorylation of extracellular signal-regulated kinase (P-ERK but not Akt, as measured by Western blot. LY294002, a selective inhibitor of PI3K that prevents activation of the downstream Akt, did not weaken the effect of CCL21/CCR7 on P-ERK. Coimmunoprecipitation further confirmed that there was an interaction between P-ERK and cyclin A, cyclin B1, or CDK1, particularly in the presence of CCL21. CCR7 small interfering RNA or PD98059, a selective inhibitor of MEK that disrupts the activation of downstream ERK, significantly abolished the effects of exogenous CCL21. These results suggest that CCL21/CCR7 contributes to the time-dependent proliferation of human NSCLC cells by upregulating cyclin A, cyclin B1, and CDK1 potentially via the ERK pathway.

  10. 蛇毒合成的信号通路%Research progress of cell signaling pathway during the onset of the snake venom production cycle

    Institute of Scientific and Technical Information of China (English)

    张宏丽; 何艳琴; 杨章民

    2012-01-01

    蛇毒液产生的周期分为活跃期和静息期两个阶段,在这两个阶段中毒腺分泌细胞的形态学和生物化学方面存在着许多不同.蛇咬物排毒或人工取毒后其释放的去甲肾上腺素(noradrenaline,NE)是分泌细胞中合成毒液所必需的,其中分泌细胞的α肾上腺素能受体(α-adrenoceptor,α-AR)和β肾上腺素能受体(β-adrenoceptor,β-AR)参与了这个过程.本文简要介绍在毒液产生周期的不同阶段中分泌细胞的变化,重点阐述了刺激α-AR和β-AR在引起毒液合成开始时所介导的相关细胞信号通路.最后简单探讨了其它刺激蛇毒腺引起毒液产生的可能因素及其调控机制.%The snake venom production cycle includes an active stage and a quiescent stage. There are many morphological and biochemical differences of the secretory epithelium in these two stages. The release of noradrenaline after a bite or manual extraction plays an essential role in triggering the venom production cycle, and both α- and β-adrenoceptors of the venom secreting cells are involved in the venom production cycle. In this paper, the morphological and biochemical changes of the secreting cells in the different stages of venom production cycle were described, and the cell signaling pathway involved in the adrenoceptor-mediated activation of the venom production cycle were introduced. Finally, other factors which probably stimulate the snake venom gland to produce venom and the related mechanisms were discussed briefly.

  11. Pathways of tumor development and progression in drug-induced nonmelanoma skin cancer: a new hope or the next great confusion?

    Science.gov (United States)

    Tchernev, Georgi; Wollina, Uwe

    2014-07-01

    The factors that lead to the clinical manifestation of the nonmelanocytic skin tumors are different. Ultraviolet radiation, infections with human papillomaviruses, and inherited or iatrogenic-induced immunosuppression (in cases of autoimmune diseases and organ transplant recipients) are considered to be some of the most important generators and/or costimulating factors supporting the appearance of "de-novo" mutations and obstruct, in one or another way, the cell cycle arrest, the programmed cell death (apoptosis), and the immunosurveillance. Preconditions are thus created for the initial persistence and subsequent proliferation of the malignant cell branch in the genome, with the simultaneous increase of the risk of nonmelanocytic skin tumor manifestation.A number of medical drugs that possess a currently well-known selective, targeting, and immunomodulating effect, like the TNF-alpha inhibitors for example, most probably possess an additional blocking action on the death receptors within the framework of the extrinsic apoptotic pathway. In this way, they seem to be one of the major factors for the clinical manifestation not only of nonmelanocytic skin but also of a number of other type of tumors with a dependency on the genetic predisposition of each separate patient.This article focuses the attention on the basic exogenic and endogenic factors that affect the regulatory processes of the cellular cycle, apoptosis, immunosurveillance, and the human inflammasome in patients with nonmelanocytic skin tumors. These processes are interwoven in a complex network and are controlled by (1) the genome regulator p53, (2) its interaction with the proapoptotic acting proteins Bak and Bax, (3) as well as the interaction with the key regulatory protein of the inflammasome-ASC/TMS1.As a process, the malignant transformation is exceptionally dynamic, plastic, and adaptive. The exterior "interferences", on the part of the clinician, in the form of a planned therapy should be

  12. 原发性开角型青光眼房水外流通路改变的研究进展%The progress of aqueous humor outflow pathway in open-angle glaucoma

    Institute of Scientific and Technical Information of China (English)

    安琳; 季健

    2011-01-01

    原发性开角型青光眼(POAG)是一种以视神经轴索及相关视网膜神经节细胞丢失为特征的视神经病变.眼压升高是POAG最重要的危险因素.大多数POAG患者眼压升高主要是房水外流阻力异常增高所致.小梁网是产生房水排出阻力的主要部位.目前多数研究者认为POAG患者小梁网功能不良与致炎因子表达、细胞老化、氧化应激损伤及细胞质成分减少等因素有关.小梁网细胞本身及细胞外基质的变化均可以引起房水外流阻力的改变,进而导致眼内压的升高.为了进一步开展对POAG发病机制的研究,有必要就目前有关POAG患者房水外流通路改变的研究进展予以综述,旨在为POAG的深入研究提供参考依据.%Primary open angle glaucoma (POAG) is defined as an optic neuropathy characterized by loss of optic nerve axons and retinal ganglion cells.Increase of intraocular pressure (IOP) is a major risk factor for POAG,which is partially due to an abnormally high aqueous humor outflow resistance in trabecular meshwork ( TM ).Trabecular outflow pathway is a key element in drainage of aqueous humor.Malfunction of TM in POAG is associated with over expression of inflammatory markers,cellular senescence,oxidative stress,and decrease of cellularity.The biological changes of TM cell and extracellular matrix compromise trabecular pathway drainage resulting in an increased IOP.This article reviewed the progression in research on aqueous humor outflow pathway emphasizing the alteration of trabecular pathway.

  13. Pathway Analysis of Vocational Training of New-generation Migrant Workers under Background of Industrial Upgrading in Guangdong Province%广东省产业升级背景下新生代农民工职业培训路径分析

    Institute of Scientific and Technical Information of China (English)

    何建华

    2015-01-01

    The paper analyzed the essential features of human resource demand under the condition of industrial upgrading in Guangdong province , as well as the current situation of human capitals of new-generation migrant workers , and pointed out that:in order to promote the transformation of the new-generation migrant workers to the middle and high skilled talents adapting the indus-trial structure of Guangdong province , we should strengthen the government ’ s responsibility for the vocational training of new-gener-ation migrant workers , establish and improve the vocational training system for new-generation migrant workers , implement the em-ployment-oriented vocational training mode , strengthen the professional training projects related to the industrial upgrading , and construct a scientific assessment mechanism of new-generation migrant workers ’ vocational training .%分析了广东省产业升级条件下人力资源需求的基本特征,以及新生代农民工的人力资本现状,指出为促进新生代农民工转变为适应广东省产业结构的中、高端技能型人才,需要加强政府在新生代农民工职业培训中的责任,建立并完善新生代农民工职业培训体系,实施以职业开发为导向的职业培训模式,强化与产业升级相关的职业培训项目,建立科学的新生代农民工职业培训评估机制。

  14. Performance in Post-compulsory Education: Evidence from Vocational and Academic Tracks

    OpenAIRE

    Cristina Lopez-Mayan

    2013-01-01

    This paper investigates the factors in_uencing grade performance in two different high school tracks (academic and vocational), including the effect of the amount of work achieved while studying. The empirical strategy analyzes grade progression through the outcomes, passing, repeating and dropping out, conditioning on previous outcomes, and dealing with the endogeneity introduced by the working variable. The analysis is based on a unique Spanish data with information on schooling and labor h...

  15. Current Progress on the Signal Transduction Pathway of Innate Immunity in Caenorhabditis Elegans%秀丽隐杆线虫先天免疫信号转导途径

    Institute of Scientific and Technical Information of China (English)

    王涛; 杜丽; 马琼; 崔玉芳

    2011-01-01

    秀丽隐杆线虫因其结构简单、易于培养、生命周期短等特点作为一种模式生物已广泛应用于神经系统、衰老机制及细胞程序性死亡的研究.与高等生物不同,秀丽隐杆线虫缺少适应性免疫途径,只有先天免疫途径在抗病原菌、抗氧化应激等方面发挥重要的作用.其体内的胰岛素/胰岛素样生长因子(insulin/IGF-1)、转化生长因子β(transforming growth factor β,TGF-β)、丝裂原激活的蛋白激酶(mitogen activated protein kinases,MAPK)和细胞程序性死亡(programmed cell death,PCD)4条免疫相关信号转导途径在不同的环境发挥着主要作用.同时,秀丽隐杆线虫的先天免疫系统在进化中有许多保守之处,这为高等生物的免疫机制研究提供了新思路.据此,就有关秀丽隐杆线虫先天免疫信号转导途径的研究进展进行了简述,期望能为人类等高等生物相关联的免疫作用研究提供借鉴和参考.%Caenorhabditis elegans (C. elegans) has been widely used as a model organism in the research of nervous system, aging mechanisms and programmed cell death, owing to its advantages of simple tissue structure,easily culture, short lifecycle. Different from higher organisms, C. elegans is lack of adaptive immune, only the innate immune plays an important role in anti-bacteria, anti-oxidative stress and so on. Four immune-related signal transduction pathway in C. elegans, including insulin-receptor-like pathway, transforming growth factor β (TGF-β) pathway, mitogen activated protein kinases (MAPK) pathway and programmed cell death (PCD) pathway play major roles in various conditions of environment. Meanwhile, the innate immune system of C.elegans is conservative in many respects, which provides new idea for research of immune mechanism in higher organisms. Accordingly. The progress on innate immune signal transduction pathway in C. elegans is reviewed,expecting to provide some reference for investigating

  16. Revitalizing Technical and Vocational Education Training for ...

    African Journals Online (AJOL)

    Revitalizing Technical and Vocational Education Training for Poverty ... with a population of 140 million people is battling with food insecurity, poverty and youth ... in education curricula, agricultural education and the rural poor was discussed.

  17. The "Rubella Bulge" and Vocational Planning.

    Science.gov (United States)

    Wyks, Hollis W.

    1980-01-01

    The increased numbers and additional handicaps of deaf students born in the 1963-65 rubella epidemic require not more postsecondary programs, but rather strengthened programs and rehabilitation approaches to vocational and independent living skill training. (Author/CL)

  18. The EC discourse on vocational training

    DEFF Research Database (Denmark)

    Cort, Pia

    2009-01-01

    This article traces the EC vocational training policy historically and describes the discursive alignments which brought the policy from a ‘common vocational training policy' as laid down in Article 128, in the Treaty of Rome to the Lisbon Lifelong Learning strategy. The argument is that vocational...... training has served as a lever for the gradual expansion of the policy field into both general and higher education and for the establishment of a European discourse on Lifelong Learning. In the article, Ball's concept of "policy as discourse" is used to identify the changing spaces of possibility within...... EC vocational training policy (Ball, What is policy? Texts, trajectories and toolboxes. Discourse, 13(2), 1993)....

  19. Vocational Information-Seeking Behavior: Another View.

    Science.gov (United States)

    Sharf, Richard S.

    1984-01-01

    Used an unobtrusive measure to examine vocational information-seeking behavior (VISB) patterns in three groups of noncollege-bound youths (N=95). Results showed no meaningful relationship between VISB and certainty of choice or Holland type. (JAC)

  20. Vocational Education in Tourism: Conceptual Framework Problems

    Directory of Open Access Journals (Sweden)

    Galina Shchuka

    2012-12-01

    Full Text Available This article analyzes the basic concepts that define the essence of the system of vocational education and helps to analyze the problem of tourism staffing support. According to authors’ hypothesis, the personnel problem is related to the imperfection of the tourism conceptual framework. As of all enterprises of travel industry only travel agencies and accommodation facilities work with tourists, the author proves that personnel training for these businesses is the major objective of vocational training in tourism.

  1. The computer paradigm in vocational guidance

    OpenAIRE

    Fogliatto, Hermelinda

    1999-01-01

    The technological advances in last decades have transformed the external resources of Vocational Counseling, Occupational Information and assessment of clients. Most computer systems follow a behaviorist-cognitive approach. However, the use of vocational counseling software is not exclusive to one conceptual approach. Computers are introduced in education from primary school; counselors and other educators are expected to use those systems. The attitude of counselors ranges from enthusiastic ...

  2. Benchmarking Danish Vocational Education and Training Programmes

    DEFF Research Database (Denmark)

    Bogetoft, Peter; Wittrup, Jesper

    This study paper discusses methods whereby Danish vocational education and training colleges can be benchmarked, and presents results from a number of models. It is conceptually complicated to benchmark vocational colleges, as the various colleges in Denmark offer a wide range of course programmes...... attempt to summarise the various effects that the colleges have in two relevant figures, namely retention rates of students and employment rates among students who have completed training programmes....

  3. Design of Trigonometry Apps for Vocational Education

    DEFF Research Database (Denmark)

    Pedersen, Jens Bjarke; Andersen, Steffen; Majgaard, Gunver

    2012-01-01

    How can smartphones apps enrich the learning of mathematicsin vocational education? This article examines how mathematics teaching can be enriched by apps using smartphone sensors such as gyroscope, compass, camera, and touch screen in a aming context. An iterative and participatory design proces...... talk about our experience in implementing our design process and subsequently summarize the pros and cons of the application and the smartphone platform and how the app developed contributes to vocational mathematics teaching....

  4. Design of Trigonometry Apps for Vocational Education

    DEFF Research Database (Denmark)

    Pedersen, Jens Bjarke; Andersen, Steffen; Majgaard, Gunver

    2012-01-01

    How can smartphones apps enrich the learning of mathematicsin vocational education? This article examines how mathematics teaching can be enriched by apps using smartphone sensors such as gyroscope, compass, camera, and touch screen in a aming context. An iterative and participatory design process...... talk about our experience in implementing our design process and subsequently summarize the pros and cons of the application and the smartphone platform and how the app developed contributes to vocational mathematics teaching....

  5. Research progress on the role of Dkk-Wnt signaling pathway on tooth development%Dkk-Wnt信号通路在牙齿发育中作用的研究进展

    Institute of Scientific and Technical Information of China (English)

    吴也可

    2012-01-01

    Mammalian tooth development is largely dependent on the sequential and reciprocal epithelial-mesenchymal interaction. Dkk-Wnt signaling pathway has become a hot point in the research field of tooth development. Dkk-Wnt signaling is proved to be critical in the process of tooth-forming cells functioning, tooth patterning, tooth morphogenesis and crown calcification. Elucidation of molecular mechanisms involved in tooth development will surely provide theoretical basis for translational clinical application of tissue engineering strategies such as tooth regeneration. This article is committed to review on the research progress regarding the role of Wnt signaling pathway on tooth development in recent years.%哺乳动物的牙齿发育是外胚层上皮与间充质间相互调控和信号交流的结果,其中Dkk-Wnt信号通路是近年来牙胚发育研究领域的热点.Dkk-Wnt信号通路已被证实在牙体形成细胞功能的发挥、牙齿模式化、形态发生、牙冠钙化过程中扮演重要作用.牙齿发生发育分子机制的深入研究,将为牙再生组织工程技术以及相关技术的临床转化提供理论基础.本文就近十年对Wnt信号通路在牙齿发育中所起作用的研究作一综述.

  6. Coagulation factor VIIa-mediated protease-activated receptor 2 activation leads to β-catenin accumulation via the AKT/GSK3β pathway and contributes to breast cancer progression.

    Science.gov (United States)

    Roy, Abhishek; Ansari, Shabbir A; Das, Kaushik; Prasad, Ramesh; Bhattacharya, Anindita; Mallik, Suman; Mukherjee, Ashis; Sen, Prosenjit

    2017-08-18

    Cell migration and invasion are very characteristic features of cancer cells that promote metastasis, which is one of the most common causes of mortality among cancer patients. Emerging evidence has shown that coagulation factors can directly mediate cancer-associated complications either by enhancing thrombus formation or by initiating various signaling events leading to metastatic cancer progression. It is well established that, apart from its distinct role in blood coagulation, coagulation factor FVIIa enhances aggressive behaviors of breast cancer cells, but the underlying signaling mechanisms still remain elusive. To this end, we investigated FVIIa's role in the migration and invasiveness of the breast cancer cell line MDA-MB-231. Consistent with previous observations, we observed that FVIIa increased the migratory and invasive potential of these cells. We also provide molecular evidence that protease-activated receptor 2 activation followed by PI3K-AKT activation and GSK3β inactivation is involved in these processes and that β-catenin, a well known tumor-regulatory protein, contributes to this signaling pathway. The pivotal role of β-catenin was further indicated by the up-regulation of its downstream targets cyclin D1, c-Myc, COX-2, MMP-7, MMP-14, and Claudin-1. β-Catenin knockdown almost completely attenuated the FVIIa-induced enhancement of breast cancer migration and invasion. These findings provide a new perspective to counteract the invasive behavior of breast cancer, indicating that blocking PI3K-AKT pathway-dependent β-catenin accumulation may represent a potential therapeutic approach to control breast cancer. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  7. Regional gray matter correlates of vocational interests

    Directory of Open Access Journals (Sweden)

    Schroeder David H

    2012-05-01

    Full Text Available Abstract Background Previous studies have identified brain areas related to cognitive abilities and personality, respectively. In this exploratory study, we extend the application of modern neuroimaging techniques to another area of individual differences, vocational interests, and relate the results to an earlier study of cognitive abilities salient for vocations. Findings First, we examined the psychometric relationships between vocational interests and abilities in a large sample. The primary relationships between those domains were between Investigative (scientific interests and general intelligence and between Realistic (“blue-collar” interests and spatial ability. Then, using MRI and voxel-based morphometry, we investigated the relationships between regional gray matter volume and vocational interests. Specific clusters of gray matter were found to be correlated with Investigative and Realistic interests. Overlap analyses indicated some common brain areas between the correlates of Investigative interests and general intelligence and between the correlates of Realistic interests and spatial ability. Conclusions Two of six vocational-interest scales show substantial relationships with regional gray matter volume. The overlap between the brain correlates of these scales and cognitive-ability factors suggest there are relationships between individual differences in brain structure and vocations.

  8. Involvement of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways in the regulation of cell cycle progression by PTHrP in colon adenocarcinoma cells.

    Science.gov (United States)

    Calvo, Natalia; Martín, María Julia; de Boland, Ana Russo; Gentili, Claudia

    2014-08-01

    Parathyroid hormone-related peptide (PTHrP) is distributed in most fetal and adult tissues, and its expression correlates with the severity of colon carcinoma. Recently we obtained evidence that in Caco-2 cells, a cell line from human colorectal adenocarcinoma, exogenous PTHrP increases the number of live cells, via ERK1/2, p38 MAPK, and PI3-kinase and induces the expression of cyclin D1, a cell cycle regulatory protein. In this study, we further investigated the role of PTHrP in the regulation of the cell cycle progression in these intestinal cells. Flow cytometry analysis revealed that PTHrP treatment diminishes the number of cells in the G0/G1 phase and increases the number in both S and G2/M phases. The hormone increases the expression of CDK6 and diminishes the amount of negative cell cycle regulators p27Kip1, p15INK4B, and p53. However, PTHrP does not modify the expression of cyclin D3, CDK4, and p16INK4A. In addition, inhibitors of ERK1/2 (PD98059), p38 MAPK (SB203580), and PI3Kinase (LY294002) reversed PTHrP response in Caco-2 cells. Taken together, our results suggest that PTHrP positively modulates cell cycle progression and changes the expression of proteins involved in cell cycle regulation via ERK1/2, p38 MAPK, and PI3K signaling pathways in Caco-2 cells.

  9. Medical sociology as a vocation.

    Science.gov (United States)

    Bosk, Charles L

    2014-12-01

    This article extends Weber's discussion of science as a vocation by applying it to medical sociology. Having used qualitative methods for nearly 40 years to interpret problems of meaning as they arise in the context of health care, I describe how ethnography, in particular, and qualitative inquiry, more generally, may be used as a tool for understanding fundamental questions close to the heart but far from the mind of medical sociology. Such questions overlap with major policy questions such as how do we achieve a higher standard for quality of care and assure the safety of patients. Using my own research, I show how this engagement takes the form of showing how simple narratives of policy change fail to address the complexities of the problems that they are designed to remedy. I also attempt to explain how I balance objectivity with a commitment to creating a more equitable framework for health care. © American Sociological Association 2014.

  10. Human Resources Development: Vocational Guidance and Vocational Training. Report VIII (2).

    Science.gov (United States)

    International Labour Office, Geneva (Switzerland).

    The report presents responses from 57 member States of the International Labor Organization (ILO) to 16 questions as part of the preparation for placing an item entitled "Human resources development: vocational guidance and vocational training" on the agenda of the 59th (1974) Session of the ILO Conference. For each of the questions, the question…

  11. Relationship of Vocational Satisfaction to the Correspondence of Job Reinforcement and Vocational Needs.

    Science.gov (United States)

    Golden, Robert R.; Weiss, David J.

    The Theory of Work Adjustment proposes that vocational satisfaction is a function of the correspondence between the reinforcers in the work environment and the individual's vocational needs. This hypothesis is tested by comparing the means and variances of measures of satisfaction for groups differing in degree of need-reinforcer correspondence.…

  12. Comparison of the Vocational Card Sort, the SDS, and the Vocational Exploration and Insight Kit.

    Science.gov (United States)

    Takai, Ricky; Holland, John L.

    1979-01-01

    The Vocational Exploration and Insight Kit (VEIK), a combination of a Vocational Card Sort, the Self-Directed Search, and an action plan, was evaluated. High school girls took each of the tests. The VEIK failed to surpass the influence of its components. (Author/BEF)

  13. From Vocational Training to Open Learning Environments: Vocational Special Needs Education during Change

    Science.gov (United States)

    Hirvonen, Maija

    2011-01-01

    This paper describes the development of education of students with special needs in vocational education. The paper is based on a case study research conducted in 2001-2005 in Jyvaskyla Municipal Federation of Vocational Education in Central Finland. The study consisted of two parts: firstly of the historical analysis of special educational…

  14. Occupational Home Economics. Access Skills. Vocational Readiness Skills. Missouri LINC. Accessing Vocational Education.

    Science.gov (United States)

    Missouri Univ., Columbia. Dept. of Practical Arts and Vocational-Technical Education.

    This document contains home economics occupations-related materials to help teachers and parents teach access skills to Missouri junior high and high school special needs students who want to pursue a vocational program in child care, custom sewing, or food service. Access skills are defined as those skills needed to access vocational education…

  15. Student and Parent Images of Vocational Education Offerings: Declining Enrollment in Vocational Education.

    Science.gov (United States)

    Rossetti, Rosemarie

    To investigate factors that influence a student not to enroll in a high school vocational curriculum, a study sought to determine the following: (1) what relationships exist between the high school students' sex, race, socioeconomic status, and curriculum choice and the students' image of vocational education; and (2) what image of vocational…

  16. Vocational Education and Training in Kuwait: Vocational Education versus Values and Viewpoints

    Science.gov (United States)

    Bilboe, Wendy

    2011-01-01

    Since the opening up of private universities and colleges in the Kuwait education system in the late 1990s, there has been an explosion of tertiary institutions (both domestic and international) established in the country, with many of them offering vocational education and training. The move towards vocational and educational training forms part…

  17. ENHANCING MASTERY OF PRACTICAL SKILLS IN STUDENTS OF VOCATIONAL AND TECHNICAL EDUCATION THROUGH ACTIVITY BASED

    Directory of Open Access Journals (Sweden)

    M.I. Odo

    2013-02-01

    Full Text Available The study seeks to understand the issues and challenges related to the implementations of activity-based instructions on vocational and technical education student in Nigeria. A survey was carried out involving vocational and technical education teachers in all six government owned technical colleges in Lagos State of Nigeria. A total of 150 teachers were selected randomly as respondents for the study. A four point scale items were designed to elicit information from the respondents. The findings of the study indicated that the techniques and the strategies adopted by the teachers of vocational education include: demonstration, field trips, projects, experiments and assignments. Various methods to evaluate students outcome include: process-product through systematic observation. It was evident from the study that constantly focusing on activity to make learning fun can actually hamper those students who make good progress without it. Based on the findings the researcher therefore concluded that good vocational and technical education teachers require the right attitude, have years of professional and practical skills and entrepreneurial experience at the workshop floor of industry and good background knowledge of engineering design.

  18. The New Reference Points for Modernizing Vocational Education Given the Informational Boom

    Directory of Open Access Journals (Sweden)

    G. F. Shafranov-Kutsev

    2012-01-01

    Full Text Available The article analyzes the peculiarities and scales of the modern informational outburst, its implications in industrial and vocational training spheres. Simultaneously, along with the growing accumulation of the information data, a considerable part of the recently stored knowledge becomes obsolete. It results in shortening a half-decay period of specialist’s competence and, therefore, requires the cardinal updating of the vocational training system. The logic of information society development brings forth the need for the compulsory higher education and various new forms of further training. Fast growing number of telecommunication facilities and information technologies make it possible to establish the unified chain of vocational training institutions over the Internet and transform the methodology approaches to organization and content of the vocational education. Their libraries tend to turn into powerful informational library centers with fundamentally new functions. The author makes the conclusion that the growing level of people’s education is the fast way to social progress and the life standards rising. 

  19. New Strategy That Delays Progression of Amyotrophic Lateral Sclerosis in G1H-G93A Transgenic Mice: Oral Administration of Xanthine Oxidoreductase Inhibitors That Are Not Substrates for the Purine Salvage Pathway.

    Science.gov (United States)

    Kato, Shinsuke; Kato, Masako; Kusano, Teruo; Nishino, Takeshi

    2016-12-01

    Amyotrophic lateral sclerosis (ALS), Lou Gehrig's disease, is a progressive fatal neurodegenerative disease that involves both upper and lower motor neurons. We orally administered 4 xanthine oxidoreductase (XOR) inhibitors to G1H-G93A mice carrying 25 transgene copy numbers of human mutant G93A superoxide dismutase 1, from 80 days of age. Three nonpurine-analogue inhibitors (TEI-6720: Febuxostat, Y-700 and FYX-051), but not allopurinol with a purine analogue ring (pyrazolo pyrimidine ring), significantly delayed disease onset, prolonged survival and the duration of disease stages, improved clinical signs, and alleviated weight loss. Exercise testing (extension reflex, inclined plane, footprint, rotarod, and beam balance tests) showed significantly improved motor function in the G1H-G93A mice treated with these 3 inhibitors. Significant amelioration of disease was seen even when TEI-6720 or Y-700 was administered after the appearance of early signs. Histopathological evaluation in the late stage revealed that G1H-G93A mice treated with TEI-6720 had well-preserved motor neurons and fewer inclusion bodies, compared with mice treated with placebo or with allopurinol. Our results indicate that these 3 nonpurine-analogue XOR inhibitors might increase the supply of high-energy compounds via the purine salvage pathway, thereby protecting motor neurons against death. This strategy may be applicable for oral therapy of ALS patients. © 2016 American Association of Neuropathologists, Inc. All rights reserved.

  20. Insulin-like growth factor-I extends in vitro replicative life span of skeletal muscle satellite cells by enhancing G1/S cell cycle progression via the activation of phosphatidylinositol 3'-kinase/Akt signaling pathway

    Science.gov (United States)

    Chakravarthy, M. V.; Abraha, T. W.; Schwartz, R. J.; Fiorotto, M. L.; Booth, F. W.

    2000-01-01

    Interest is growing in methods to extend replicative life span of non-immortalized stem cells. Using the insulin-like growth factor I (IGF-I) transgenic mouse in which the IGF-I transgene is expressed during skeletal muscle development and maturation prior to isolation and during culture of satellite cells (the myogenic stem cells of mature skeletal muscle fibers) as a model system, we elucidated the underlying molecular mechanisms of IGF-I-mediated enhancement of proliferative potential of these cells. Satellite cells from IGF-I transgenic muscles achieved at least five additional population doublings above the maximum that was attained by wild type satellite cells. This IGF-I-induced increase in proliferative potential was mediated via activation of the phosphatidylinositol 3'-kinase/Akt pathway, independent of mitogen-activated protein kinase activity, facilitating G(1)/S cell cycle progression via a down-regulation of p27(Kip1). Adenovirally mediated ectopic overexpression of p27(Kip1) in exponentially growing IGF-I transgenic satellite cells reversed the increase in cyclin E-cdk2 kinase activity, pRb phosphorylation, and cyclin A protein abundance, thereby implicating an important role for p27(Kip1) in promoting satellite cell senescence. These observations provide a more complete dissection of molecular events by which increased local expression of a growth factor in mature skeletal muscle fibers extends replicative life span of primary stem cells than previously known.

  1. Berberine attenuates high glucose-induced proliferation and extracellular matrix accumulation in mesangial cells: involvement of suppression of cell cycle progression and NF-κB/AP-1 pathways.

    Science.gov (United States)

    Lan, Tian; Wu, Teng; Chen, Cheng; Chen, Xiaolan; Hao, Jie; Huang, Junying; Wang, Lijing; Huang, Heqing

    2014-03-25

    Berberine has been shown to have renoprotective effects on diabetes through attenuating TGF-β1 and fibronectin (FN) expression. However, how berberine regulates TGF-β1 and FN is not fully clear. Here we investigated whether berberine inhibited TGF-β1 and FN expression in high glucose-cultured mesangial cells. Berberine significantly inhibited mesangial cell proliferation and hypertrophy by increasing the cell population in G1-phase and reducing that in S-phase. In addition, berberine reversed high glucose-induced down-regulation of cyclin-dependent kinase inhibitor p21(Waf1)/(Cip1) and p27(Kip1). Berberine inhibited p65 translocation to the nucleus and c-jun phosphorylation induced by high glucose. Furthermore, berberine attenuated high glucose-induced expression of TGF-β1 and FN. Using a luciferase reporter assay, we found that high glucose-induced transcription activity of NF-κB and AP-1 was blocked by berberine. Electrophoretic mobility shift assay showed that high glucose increased that NF-κB and AP-1 DNA binding activity. These data indicate that berberine inhibited mesangial cell proliferation and hypertrophy by modulating cell cycle progress. In addition, berberine suppressed high glucose-induced TGF-β1 and FN expression by blocking NF-κB/AP-1 pathways.

  2. 核糖体蛋白家族成员与 MDM 2-p53通路调控的研究进展%Research progress of the relationship between ribosomal protein and MDM 2-p 5 3 pathway

    Institute of Scientific and Technical Information of China (English)

    刘弘扬; 孙冬琳; 孙海明; 金焰

    2016-01-01

    肿瘤是危害人类生命健康的最主要的疾病之一。 p53是目前为止研究最多的抑癌基因,p53的功能紊乱是肿瘤发生最主要的原因。核糖体蛋白发挥核糖体外功能抑制鼠双微体基因2( murine double minute 2, MDM 2)并激活 P 53是近十年的研究热点。本文就核糖体蛋白与 MDM 2-p 53通路调控关系及其与肿瘤治疗的研究进展进行综述。%Cancer is one of the most life threatening diseases .The dysfunction of the p 5 3 , as one of the most studied tumor-suppressor genes so far , is the main reason for tumorigenesis .Many studies over the past decades reveal that the ribosome-free ribosomal protein inhibits the MDM 2 and actives the P 5 3 .This review focuseon the progress in studying on the relationship between the ribosomal protein on the MDM 2-p 5 3 regulatory pathway and its roles incancer therapy .

  3. Insulin-like growth factor-I extends in vitro replicative life span of skeletal muscle satellite cells by enhancing G1/S cell cycle progression via the activation of phosphatidylinositol 3'-kinase/Akt signaling pathway

    Science.gov (United States)

    Chakravarthy, M. V.; Abraha, T. W.; Schwartz, R. J.; Fiorotto, M. L.; Booth, F. W.

    2000-01-01

    Interest is growing in methods to extend replicative life span of non-immortalized stem cells. Using the insulin-like growth factor I (IGF-I) transgenic mouse in which the IGF-I transgene is expressed during skeletal muscle development and maturation prior to isolation and during culture of satellite cells (the myogenic stem cells of mature skeletal muscle fibers) as a model system, we elucidated the underlying molecular mechanisms of IGF-I-mediated enhancement of proliferative potential of these cells. Satellite cells from IGF-I transgenic muscles achieved at least five additional population doublings above the maximum that was attained by wild type satellite cells. This IGF-I-induced increase in proliferative potential was mediated via activation of the phosphatidylinositol 3'-kinase/Akt pathway, independent of mitogen-activated protein kinase activity, facilitating G(1)/S cell cycle progression via a down-regulation of p27(Kip1). Adenovirally mediated ectopic overexpression of p27(Kip1) in exponentially growing IGF-I transgenic satellite cells reversed the increase in cyclin E-cdk2 kinase activity, pRb phosphorylation, and cyclin A protein abundance, thereby implicating an important role for p27(Kip1) in promoting satellite cell senescence. These observations provide a more complete dissection of molecular events by which increased local expression of a growth factor in mature skeletal muscle fibers extends replicative life span of primary stem cells than previously known.

  4. The Business English Teaching in Vocational Technology College

    Institute of Scientific and Technical Information of China (English)

    张洁

    2013-01-01

    The vocational business English teaching should adapt to the requirments of enterprise, focus on the practical applica⁃tion of business English, and empolder a teaching mode with vocational characteristics.

  5. Vocational Rehabilitation of Persons with Spinal Cord Injuries

    Science.gov (United States)

    Poor, Charles R.

    1975-01-01

    Reviews historical development of organized vocational rehabilitation programming for the spinal cord injured in the United States. Significant factors that affect vocational rehabilitation outcomes with spinal cord injured persons are listed and discussed. (Author)

  6. Factors Concerning Students' Perceptions of Teaching Vocational Agriculture.

    Science.gov (United States)

    Miller, W. Wade; And Others

    1984-01-01

    The purpose of the study was to determine the degree to which high school senior vocational agriculture students perceived vocational agriculture teachers' roles and responsibilities as encouraging or discouraging them to pursue a career in agricultural education. (JOW)

  7. Bilingual Vocational Education for Youths with Limited English Proficiency.

    Science.gov (United States)

    Bateman, Mary Jo

    1993-01-01

    Describes the Bilingual Vocational Education Program for Refugee Youth in Richmond, Virginia. Presents data that support the concept of mainstreaming refugee youth with limited English proficiency into public vocational education programs using the assistance of bilingual aides. (Author)

  8. Effective Management of Wastages in Vocational Education for ...

    African Journals Online (AJOL)

    gold

    2012-07-26

    Jul 26, 2012 ... Abstract. This paper focused on the management of wastages in vocational Education for sustainable ... A number of strategies were proffered to curb wastages in vocational ..... CHEEBAL Global Prints, Ltd. Offiong A.A., Okon ...

  9. Holland's Theory of Vocational Choice and Postulated Value Dimensions.

    Science.gov (United States)

    Laudeman, Kent A.; Griffeth, Paul

    1978-01-01

    The validity of Holland's vocational personality types and their relationship to value dimensions were examined in light of Holland's theory of vocational choice. The results generally supported Holland's postulated personality typologies and value dimensions. (Author/JKS)

  10. Holland's Theory of Vocational Choice and Postulated Value Dimensions.

    Science.gov (United States)

    Laudeman, Kent A.; Griffeth, Paul

    1978-01-01

    The validity of Holland's vocational personality types and their relationship to value dimensions were examined in light of Holland's theory of vocational choice. The results generally supported Holland's postulated personality typologies and value dimensions. (Author/JKS)

  11. Teachers’ perceptions of the coaching role in secondary vocational education

    NARCIS (Netherlands)

    Ketelaar, Evelien; Den Brok, Perry; Beijaard, Douwe; Boshuizen, Els

    2012-01-01

    Ketelaar, E., Den Brok, P., Beijaard, D., & Boshuizen, H. P. A. (2012). Teachers’ perceptions of the coaching role in secondary vocational education. Journal of Vocational Education & Training, 64(3), 295-315. doi:10.1080/13636820.2012.691534

  12. The European Dimensions of Vocational Training

    Directory of Open Access Journals (Sweden)

    Sós Tamás

    2015-12-01

    Full Text Available The research examined the connection between vocational education, training and the world of work, and the social situation in Hungary in a European outlook. The accentual issues of the analysis disclosing the problem are: youth unemployment, the tendencies of secondary vocational education, proportions of enrollment and the features of training tendencies, the growing number of early dropouts, the effect of family background on student performance. This work tried to find the answer to the question: What variations have the changes in the regulations of vocational training, encouraging dual education brought on in the connection between trainers and work places? The research did not prove that the central vocational training system would be more effective than a varied, flexible, permeable, transparent decentralized operation with parts built on each other. The introduction of the complex exam overshadowed the evaluation of the competency areas, and fits less to the modularity of the framework curricula. With the legal regulation of vocational training in force the modular system has become a formality. Taking prior knowledge into account has become more difficult. The efficiency of professional structural decisions is questionable, it has not triggered the extension of employment among career starters, and does not mean a guarantee of finding a job either. Creating the motivation of economic role players may bring on steps forward to take up bigger tasks in vocational training. The research has confirmed the importance of improving the basic competency areas when planning vocational training, of life-long learning, of practice orientation, and also of the continuous connection with the labor market.

  13. Evolution of vocational rehabilitation competencies in Australia.

    Science.gov (United States)

    Matthews, Lynda R; Buys, Nicholas; Randall, Christine; Biggs, Herbert; Hazelwood, Zoe

    2010-06-01

    Over the past decade, there has been growth in the delivery of vocational rehabilitation services globally, as countries seek to control disability-related expenditure, yet there has been minimal research outside the United States on competencies required to work in this area. This study reports on research conducted in Australia to determine current job function and knowledge areas in terms of their importance and frequency of use in the provision of vocational rehabilitation. A survey comprising items from the Rehabilitation Skills Inventory-Amended and International Survey of Disability Management was completed by 149 rehabilitation counselors and items submitted to factor analysis. T-tests and analyses of variance were used to determine differences between scores of importance and frequency and differences in scores based on work setting and professional training. Six factors were identified as important and frequently used: (i) vocational counseling, (ii) professional practice, (iii) personal counseling, (iv) rehabilitation case management, (v) workplace disability case management, and (vi) workplace intervention and program management. Vocational counseling, professional practice and personal counseling were significantly more important and performed more frequently by respondents in vocational rehabilitation settings than those in compensation settings. These same three factors were rated significantly higher in importance and frequency by those with rehabilitation counselor training when compared with those with other training. In conclusion, although 'traditional' knowledge and skill areas such as vocational counseling, professional practice, and personal counseling were identified as central to vocational rehabilitation practice in Australian rehabilitation agencies, mean ratings suggest a growing emphasis on knowledge and skills associated with disability management practice.

  14. The Analysis of Vocational Aptitude Changing with Age

    OpenAIRE

    Wada, Masayuki; OGAWA, Kazuo; Akagi, Fumio; Osaki, Hirokazu; Kikuchi, Susumu

    1980-01-01

    The assumption that vocational aptitude changed with age and with the kind of occupation was examined from the tendency of the fitted curve for the score of the aptitude test. 9 vocational aptitudes were measured by the general vocational aptitude test by Japan Labor Ministry. Subjects were 382 male workers (design engineers, turners, welders, can manufacturing workers, and crane operators) of from 20 to 59 years old, and 348 male and female students (junior high school, vocational school, an...

  15. Schools and Work: Developments in Vocational Education. Cassell Education Series.

    Science.gov (United States)

    Coffey, David

    This book assesses the developing vocational functions of schools in Britain, identifies vocational values and policies, and discovers gaps in provision. Chapter 1 gives a summary analysis of school structural and curricular developments between medieval times and the reign of Victoria that were inspired by vocational or economic influences or had…

  16. 20 CFR 229.81 - Refusal to accept vocational rehabilitation.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Refusal to accept vocational rehabilitation... Refusal to accept vocational rehabilitation. The DIB O/M is not payable for any month in which the disabled employee refuses, without good reason, to accept vocational rehabilitation services...

  17. A Theory-Ridden, Computerless, Impersonal Vocational Guidance System.

    Science.gov (United States)

    Holland, John L.

    Beginning with a brief summary of the need for practical vocational guidance systems, the author explains his Self Directed Search for Educational and Vocational Planning (SDS), which was developed to provide a cheap, practical, vocational guidance system having a high degree of scientific validty and client effectiveness. The SDS is a…

  18. Institutionalization of Higher Vocational Education in China: A Neoinstitutionalist Perspective

    Science.gov (United States)

    Xiong, Jie

    2013-01-01

    From the perspective of neoinstitutionalism, higher vocational education has become an emerging institution in Chinese society. Its development over three decades entails a trend of institutionalization of higher vocational education. In such a process, higher vocational education is gaining legitimacy and experiencing isomorphic changes. Various…

  19. History of Adult Vocational Education in New Brunswick.

    Science.gov (United States)

    New Brunswick Dept. of Education, Fredericton (Canada).

    This paper traces the development of adult vocational education in New Brunswick from its beginning in 1918 to the present. Highlights summarize the adult vocational history before confederation and to World War I, when the first Vocational Education Act was passed in 1918. The paper then summarizes the events of World War I and the Depression…

  20. Vocational Profiles and Internship Quality among Portuguese VET Students

    Science.gov (United States)

    Gamboa, Vitor; Paixão, Maria Paula; de Jesus, Saúl Neves

    2014-01-01

    The provision of workplace-based experiences (internships) is an important component of the training program for students attending vocational education courses. The purpose of this study was to clarify the relationship between internship quality and students vocational development, considering students' vocational profiles, in a sample of 346…

  1. Working Partnerships: A Joint Venture in Vocational Education.

    Science.gov (United States)

    Campbell, Clifton P.

    Joint Ventures in Vocational Education projects link participating businesses with secondary vocational programs in a cooperative relationship. These are voluntary arrangements between vocational programs and a public or private sector agency that combine the energies and resources of the partners to enrich various aspects of the vocational…

  2. Recent Research on Labor Market Outcomes of Secondary Vocational Education.

    Science.gov (United States)

    Lewis, Morgan V.

    This paper synthesizes the results of recent research on the labor market outcomes associated with participation in secondary vocational education. It is based on 10 studies conducted with national data and reported since passage of the 1976 amendments to the Vocational Education Act of 1963. Despite the problems of analyzing vocational outcomes…

  3. Critical Perspectives on Adolescent Vocational Guidance in Chile

    Science.gov (United States)

    McWhirter, Ellen Hawley; McWhirter, Benedict T.

    2012-01-01

    In this article, the lens of critical psychology is applied to adolescent career development and vocational guidance in Chile. The authors describe and critique the status of adolescent vocational guidance in Chile, the reproduction of extant social inequities in Chilean education, and offer recommendations for enhancing vocational guidance…

  4. Vocational Training in the Development Process. The Singapore Experience.

    Science.gov (United States)

    Pillay, G. F.

    The planning and implementation of vocational training in Singapore (training primarily intended for school-leavers) is highly directed toward serving labor force development objectives. This paper explains the vocational training infrastructure (a national system, the conduct of which is vested in the Vocational and Industrial Training Board),…

  5. The Relative Good of Work: Reconsidering Vocation Eschatologically

    Science.gov (United States)

    Vos, Pieter

    2017-01-01

    Vocation, interpreted as the calling of every individual believer to serve God in ordinary life, has been an important feature of Protestantism. However, not only has the notion of vocation gradually disappeared from the late modern understanding of work and profession, the identification of vocation and work has also been criticized by…

  6. Erik Erikson's Theory of Psychosocial Development and Vocational Behavior

    Science.gov (United States)

    Munley, Patrick H.

    1975-01-01

    Stage resolution attitudes, derived from the first six stage crises outlined by Erikson, were explored as variables influencing problems in vocational choice and vocational maturity. Findings indicated students who made adjusted vocational choices and developed mature career attitudes had also been more successful resolving the first six…

  7. Working Partnerships: A Joint Venture in Vocational Education.

    Science.gov (United States)

    Campbell, Clifton P.

    Joint Ventures in Vocational Education projects link participating businesses with secondary vocational programs in a cooperative relationship. These are voluntary arrangements between vocational programs and a public or private sector agency that combine the energies and resources of the partners to enrich various aspects of the vocational…

  8. Critical Perspectives on Adolescent Vocational Guidance in Chile

    Science.gov (United States)

    McWhirter, Ellen Hawley; McWhirter, Benedict T.

    2012-01-01

    In this article, the lens of critical psychology is applied to adolescent career development and vocational guidance in Chile. The authors describe and critique the status of adolescent vocational guidance in Chile, the reproduction of extant social inequities in Chilean education, and offer recommendations for enhancing vocational guidance…

  9. Professional Identities of Vocational High School Students and Extracurricular Activities

    Science.gov (United States)

    Altan, Bilge Aslan; Altintas, Havva Ozge

    2017-01-01

    Vocational high schools are one of the controversial topics, and also the hardly touched fields in educational field. Students' profiles of vocational schools, their visions, and professional identity developments are not frequently reflected in the literature. Therefore, the main aim of the study is to research whether vocational high school…

  10. Financing Technical and Vocational Education: Modalities and Experiences.

    Science.gov (United States)

    German Foundation for International Development (DSE), Bonn (Germany).

    The two papers in this document explain various options and modalities for UNEVOC (International Project on Technical and Vocational Education) Member States' financing of their individual systems of technical and vocational education and disseminating experiences in this area. "Financing Vocational Education and Training in Developing…

  11. The Effects of Vocational Leadership Development for Individuals Who Participated in the Ohio Vocational Education Leadership Institute.

    Science.gov (United States)

    Leimbach, Gale John

    The effects of vocational leadership development were studied for 23 Fellows enrolled in the 1992 Ohio Vocational Education Leadership Institute (OVELI). A literature review focused on four components: leadership styles, educational leadership development, vocational leadership development, and visionary leadership development. The Leadership…

  12. MDM2/p53通路与心血管疾病的研究进展%The Research Progress of Mdm2/p53 Pathway and Cardiovascular Disease

    Institute of Scientific and Technical Information of China (English)

    羊暑艳

    2011-01-01

    鼠双微基因2(MDM2)是一原癌基因,因mRNA的不同剪切可形成多种不同相对分子质量的变异体,如p57、p64、p85、p90等.在正常细胞中,MDM2和野生型p53有着精细的平衡,其相互调节形成负反馈回路:p53诱导MDM2表达,MDM2与p53结合形成p53-MDM2复合物,使p53泛素化而被蛋白酶降解.MDM2-p53反馈体系与其他信号转导途径一起形成调控网络,参与细胞生长抑制、凋亡、细胞周期调控等各种生物进程.现对MDM2/p53途径在心血管疾病中的研究进展进行综述.%Murine double minute 2( Mdm2 )gene is an oncogene,due to the different cuttings of mRNA, a variety of variants with different molecular weight can be formed, such as p57, p64, p85, p90 and so on. In normal cells, Mdm2 and wild - type p53 has a delicate balance. The Interaction between them form a negative feedback loop:p53 induces the expression of Mdm2,the combination of Mdm2 and p53 forms a compound named p53-Mdm2. It makes p53 to be ubiquitinationed and then degraded by protease. Regulatory networks formed by Mdm2-p53 feedback system and other signaling pathways involved in cell growth inhibition,apop-tosis, cell cycle regulation and other biological processes. Here is to review the progress of the Mdm2/p53 pathways in cardiovascular disease research.

  13. Keap1-Nrf2-ARE通路在肺部疾病中的研究进展%Progress of Keapl-Nrf2-ARE signaling pathway in lung diseases

    Institute of Scientific and Technical Information of China (English)

    林晓萍; 曾奕明

    2016-01-01

    核因子E2相关因子2(Nrf2)是细胞调节抗氧化应激反应的重要转录因子,通过与其胞浆伴侣蛋白Keap1和抗氧化反应元件(ARE)相互作用,启动编码抗氧化蛋白和Ⅱ相解毒酶的基因表达,在细胞防御保护中发挥作用.Nrf2缺失或激活障碍,将加重氧化应激源的细胞毒性,导致细胞功能障碍、凋亡甚至死亡.Keap1-Nrf2-ARE通路在炎症、肿瘤、衰老、凋亡、神经损伤、呼吸系统疾病、心血管疾病和自身免疫病等疾病中发挥广泛的细胞保护功能.本文对Keap1-Nrf2-ARE通路在肺部疾病中的最新研究进展进行了综述.%Nuclear factor-erythroid 2 related factor 2 (Nrf2) is a nuclear transcription factor involved in a variety of protein expression and is a center of oxidative stress regulation.Under normal homeostatic conditions,Nrf2 transcription is repressed by its negative regulator Kelch-like ECH-associated protein-1 (Keap1).However,upon exposure to oxidative stress,Nrf2 dissociates from cytosolic Keap1 and translocates to the nucleus,where it combines with antioxidant response element (ARE) in the promoter region of genes encoding antioxidant enzymes and phase Ⅱ detoxifying enzymes,and activates downstream multiple anti-inflammatory,antioxidant,and antitumor biochemical treatment.In addition,disruption of Nrf2 will aggravate the cytotoxicity of oxidative stress,leading to the cellular dysfunction,apoptosis or death.This signaling pathway involves in inflammation,tumor,aging,apoptosis,nervous injury,respiratory diseases,cardiovascular diseases,autoimmune diseases and so on.This review describes the basic structure and biological effects of Keap1-Nrf2-ARE signaling pathway,and summarizes the latest progress in lung diseases.

  14. 抑郁症相关受体、细胞因子及信号通路的研究进展%Progress of Receptors, Cytokine and Signal Pathways about Depression

    Institute of Scientific and Technical Information of China (English)

    董栋; 王蕊

    2012-01-01

    抑郁症是指某种不愉快的心境和一定身体器官的功能紊乱,是一种精神病理状态,迄今为止对抑郁症的治疗及病因研究已有一定的进展,目前的研究认为五羟色胺、多巴胺等单胺类神经递质与抑郁症的发生和治疗有密切的关系,同时,有研究也发现谷氨酸、糖皮质激素等非单胺类系统也与抑郁症密切相关。大量研究显示,在抑郁症患者脑中细胞外调节蛋白激酶的活性降低,而且抑制该酶的活性在动物模型上可表现出类似抑郁的行为。脑源性神经营养因子在抑郁症患者及抑郁症动物模型血液中的水平与正常对照相比均有明显的下调,而且脑源性神经营养因子在抑郁动物模型上有抗抑郁的作用。该文主要对近期与抑郁症相关的受体、细胞因子及细胞通路研究进行综述。%Depression is a mental disease with negative mood and dysfunction of organs. The study of the pathogenesis of depression has made great progress. The current research demonstrates that the disorder of serotonin system and dopamine system are related to depression; a close relationship between depression and the disorder of monoaminergic systems has been repeatedly reported. Researchers also find that the glutamatergic system and glucocorticoid system affect the development and progress of depression. The level of brain-derived neurotrophic factor is significantly decreased in the blood of depressed patients and animal models, and brain-derived neruotrophic factor has a therapeutic effect in animal models of depression. Extracellular signal-regulated kinase is also decreased in depressed patients. This review summarizes the recent understanding about the receptors, cytokine and signal pathway that are thought to be involved in the pathophysiology of depression.

  15. S100A8 and S100A9 are associated with colorectal carcinoma progression and contribute to colorectal carcinoma cell survival and migration via Wnt/β-catenin pathway.

    Directory of Open Access Journals (Sweden)

    Liang Duan

    Full Text Available BACKGROUND AND OBJECTIVE: S100A8 and S100A9, two members of the S100 protein family, have been reported in association with the tumor cell differentiation and tumor progression. Previous study has showed that their expression in stromal cells of colorectal carcinoma (CRC is associated with tumor size. Here, we investigated the clinical significances of S100A8 and S100A9 in tumor cells of CRC and their underlying molecular mechanisms. METHODS: Expression of S100A8 and S100A9 in colorectal carcinoma and matching distal normal tissues were measured by reverse transcriptase polymerase chain reaction (RT-PCR, immunohistochemistry and western blot. CRC cell lines treated with the recombinant S100A8 and S100A9 proteins were used to analyze the roles and molecular mechanisms of the two proteins in CRC in vitro. RESULTS: S100A8 and S100A9 were elevated in more than 50% of CRC tissues and their expression in tumor cells was associated with differentiation, Dukes stage and lymph node metastasis. The CRC cell lines treatment with recombinant S100A8 and S100A9 proteins promoted the viability and migration of CRC cells. Furthermore, the two recombinant proteins also resulted in the increased levels of β-catenin and its target genes c-myc and MMP7. β-catenin over-expression in CRC cells by Adβ-catenin increased cell viability and migration. β-catenin knock-down by Adsiβ-catenin reduced cell viability and migration. Furthermore, β-catenin knockdown also partially abolished the promotive effects of recombinant S100A8 and S100A9 proteins on the viability and migration of CRC cells. CONCLUSIONS: Our work demonstrated that S100A8 and S100A9 are linked to the CRC progression, and one of the underlying molecular mechanisms is that extracellular S100A8 and S100A9 proteins contribute to colorectal carcinoma cell survival and migration via Wnt/β-catenin pathway.

  16. Vocational and Technical Education Master's Employment-oriented Study

    Institute of Scientific and Technical Information of China (English)

    王晋琳

    2011-01-01

    In recent years,as China's rapid economic development,vocational and technical education has been gradually recognized by the society.As highly educated people,vocational and technical education graduate is an important force in the development of vocational education.But in reality,their employment orientation deviate from the trend of the profession and only a small part of them do related work after graducation.Combined with the current development status of vocational education,the article analysis the reasons of this problem and give policy recommendations,so as to create a good environment for vocational and technical education talented people.

  17. Reforming vocational didactics by implementing a new VET teacher education

    DEFF Research Database (Denmark)

    Duch, Henriette; Andreasen, Karen Egedal

    2015-01-01

    A new education program, Diploma of Vocational Pedagogy, has recently been implemented in Denmark to upskill vocational college teachers and improve didactics at VET colleges in general. Among many challenges, vocational college teachers have to adapt their pedagogy to a large number of students...... interviews with students from the Diploma of Vocational Pedagogy program and concepts developed by Bernstein and Bourdieu, the article analyzes how these aspects might affect the development of new vocational didactics. We know that it is not easy to change the culture of educational institutions...

  18. Reforming vocational didactics by implementing a new VET teacher education

    DEFF Research Database (Denmark)

    Duch, Henriette; Andreasen, Karen Egedal

    2015-01-01

    from backgrounds with no tradition for education. Despite historical changes, the education as vocational college teacher also struggles with the interplay between theory and practice in the program and great diversity among vocational college teachers. Based on empirical data from focus group......A new education program, Diploma of Vocational Pedagogy, has recently been implemented in Denmark to upskill vocational college teachers and improve didactics at VET colleges in general. Among many challenges, vocational college teachers have to adapt their pedagogy to a large number of students......, and the analysis uncovers several factors that are expected to hamper the development processes....

  19. Vocation in theology-based nursing theories.

    Science.gov (United States)

    Lundmark, Mikael

    2007-11-01

    By using the concepts of intrinsicality/extrinsicality as analytic tools, the theology-based nursing theories of Ann Bradshaw and Katie Eriksson are analyzed regarding their explicit and/or implicit understanding of vocation as a motivational factor for nursing. The results show that both theories view intrinsic values as guarantees against reducing nursing practice to mechanistic applications of techniques and as being a way of reinforcing a high ethical standard. The theories explicitly (Bradshaw) or implicitly (Eriksson) advocate a vocational understanding of nursing as being essential for nursing theories. Eriksson's theory has a potential for conceptualizing an understanding of extrinsic and intrinsic motivational factors for nursing but one weakness in the theory could be the risk of slipping over to moral judgments where intrinsic factors are valued as being superior to extrinsic. Bradshaw's theory is more complex and explicit in understanding the concept of vocation and is theologically more plausible, although also more confessional.

  20. Vocational Counseling and Training for Medical Degrees

    Directory of Open Access Journals (Sweden)

    Belkis Mercedes Vicente Sánchez

    2014-04-01

    Full Text Available Deciding on a university degree is undoubtedly a difficult choice. This situation brings about fear of failing and disappointing yourself and others, which is a common feeling among high school students, becoming a source of anxiety and stress. This demonstrates the need for an appropriate vocational and professional guidance. In Cuba, this subject is gaining importance, since a greater number of youngsters have the opportunity to choose from more professions; thus, deciding on one or the other is a problem of great practical and social impact. Vocational guidance and training in the Cuban educational context aims to reaffirm the inclination of youth towards medical studies, where they fully develop their potential, on the basis of consolidating values and feelings, and a high social, moral and unconditional commitment to the practice of the profession. This paper presents various issues that currently affect vocational guidance and the role of each of the major participants in the process itself.

  1. Wellbeing and smoking at Danish vocational schools

    DEFF Research Database (Denmark)

    Andersen, Susan; Rod, Morten Hulvej; Ersbøll, Annette Kjær

    Background School dropout and health risk behavior represent major problems among students attending vocational education in Denmark and many other countries. Modifications to the social environment may promote educational attainment as well as the health and wellbeing of young people. However......, there is a need for more evidence-based intervention programs. The aim of this study was to assess the effectiveness of a settings-based intervention (Shaping the Social) at vocational schools on student wellbeing and smoking. Methods We employed a non-randomized controlled trial of 5794 students (mean age 21...... years; 81% male) in 10 (four intervention and six comparison) large vocational schools in Denmark. The intervention integrated social activities with professional learning and focused on four themes: introduction activities; daily class meetings; scheduled breaks; creating a pleasant non-smoking...

  2. Are Graduates Preferred to Those Completing Initial Vocational Education and Training? Case Studies on Company Recruitment Strategies in Germany, England and Switzerland

    Science.gov (United States)

    Hippach-Schneider, Ute; Weigel, Tanja; Brown, Alan; Gonon, Philipp

    2013-01-01

    The German and Swiss economies value skilled work highly and initial vocational education and training (IVET) has been the predominant traditional pathway into such work. However, concerns about a more "knowledge-based society" and the "academic shift in the labour market" are starting to undermine the status associated with…

  3. Benchmarking Danish Vocational Education and Training Programmes

    DEFF Research Database (Denmark)

    Bogetoft, Peter; Wittrup, Jesper

    This study paper discusses methods whereby Danish vocational education and training colleges can be benchmarked, and presents results from a number of models. It is conceptually complicated to benchmark vocational colleges, as the various colleges in Denmark offer a wide range of course programmes....... This makes it difficult to compare the resources used, since some programmes by their nature require more classroom time and equipment than others. It is also far from straightforward to compare college effects with respect to grades, since the various programmes apply very different forms of assessment...

  4. Questioning Styles in Vocational College English Classrooms

    Institute of Scientific and Technical Information of China (English)

    舒立志

    2011-01-01

    This study investigates the effects of TBLT reform in Higher Vocational Colleges from the perspective of questioning styles.It employs three methods to collect data:classroom observation,semi-structured interviews and focus group discussion with eight English teachers and their 384 non-English major students from three Higher Vocational Colleges in Guangdong.The results indicated that the teachers assigned students different tasks to perform in class.They seemed to be adopting the TBLT approach,but their English classes were not totally different from the teacher-centered grammar-focused lessons,the student-centered or communicative lessons.

  5. The effects of school systems, teacher internal characteristics, and students on vocational teacher stress

    OpenAIRE

    Adams, Elaine

    1996-01-01

    Job stress is a multidimensional phenomenon. The researcher sought to examine variables that cause vocational teachers to experience stress in their teaching occupations and to evaluate the effects of these related stressors. This research evaluated the relationships between school systems and vocational teacher stress, teacher internal characteristics and vocational teacher stress, and students and vocational teacher stress. It also analyzed vocational teacher stre...

  6. An Educational–Vocational Intervention

    Directory of Open Access Journals (Sweden)

    Kalervo Friberg

    2013-07-01

    Full Text Available Changes in student-affective entry characteristics were examined in an educational−vocational intervention at Finnish comprehensive school. The conceptual framework constructed from attitudes as learned dispositions (Fishbein & Ajzen, 1975 and self-determination (Deci & Ryan, 1985 was tested in a longitudinal study. A person-based survey questionnaire was designed, piloted, and validated. Spearman−Brown reliability was calculated. In the first observation, 669 (Time One Cohort, and in the second, 649 (Time Two Cohort subjects (girls and boys of mean ages of 14.5 and 16.0 years took the Web-based survey. The tested hypotheses were (a variables of self-determination, self-regulation, and intrinsic and extrinsic motivation would emerge as attitudinal domains in work−life orientation; (b the experiences during the implementation of a work−life orientation program would decrease the effects of seventh-grade student background factors at the end of the program in the ninth grade, and (c work−life orientation would be effective and have efficacy in changing student attitudes in relation to further education and occupations. Three factors emerged in the Maximum Likelihood Factor Analysis. The factors Independence, Self-Direction, and Flexibility were used as the dependents in repeated measures in a general linear model. The factor means were subjected to a paired samples t test. There was development toward stronger Independence and Flexibility in the case of both genders. The boys had gained the girls’ seventh-grade lead at the end of the program. Self-Direction did not show any changes. Empirical findings tentatively supported the program’s efficacy in changing entry characteristics.

  7. Perspectives on Vocational Behavior, 1986: A Review.

    Science.gov (United States)

    Slaney, Robert B.; Russell, Joyce E. A.

    1987-01-01

    Based on perspectives of counseling psychology and industrial/organizational psychology, this article reviews publications relevant to vocational behavior that appeared during 1986. Of the over 700 articles and 70 books or book chapters located, slightly less than one-half are reviewed. (Author/NB)

  8. Global Reconstructions of Vocational Education and Training

    Science.gov (United States)

    Avis, James

    2012-01-01

    In this introduction to the special issue, the author examines the wider context within which vocational education and training (VET) is set and the surrounding debates. He considers the prominence of neoliberalism and notions of competitiveness, crisis, skill and knowledge. Despite differences between systems of VET with respect to their reach…

  9. John Holland's Vocational Typology and Personality Theory.

    Science.gov (United States)

    Hogan, Robert; Blake, Rex

    1999-01-01

    The literature provides evidence of links between measures of personality and vocational interests as theorized by Holland. Personality and interest assessments offer critical information for predicting career success. Personality assessment reflects the individual viewed by an observer and interest measurement reflects the individual's…

  10. Diagnostic Scheme for Specifying Vocational Assistance.

    Science.gov (United States)

    Holland, John L.; And Others

    The validity of some theoretically-derived vocational diagnostic signs was examined to learn if a person's self-knowledge, occupational knowledge, and decision-making ability were predictable. Diverse samples of high school juniors (N = 1005), college juniors (N = 692), and employed adults (N = 140) were administered the Self-Directed Search (the…

  11. Vocational Rehabilitation for Women with Disabilities.

    Science.gov (United States)

    Stace, Sheila

    1987-01-01

    Women with disabilities have limited access to the labor market owing to the double disadvantage of being both disabled and female. The current rehabilitation system is inadequate to meet this population's needs. Further research, broader action programs, changes in vocational rehabilitation, and active measures against discrimination are needed.…

  12. Achieving Sex Equity via Vocational Education.

    Science.gov (United States)

    Goetsch, David L.; Gulledge, Earl N.

    1981-01-01

    Reviews the women's rights movement and discusses the evolution of society's attitudes toward women. Discusses the goals and methods of Okaloosa-Walton Junior College Sex Equity Plan, a vocational education program for achieving sex equity. Highlights five major components: education, student recruitment, self-paced, self-directed instruction, job…

  13. Ordinal Position Research Related to Vocational Interest

    Science.gov (United States)

    Gandy, Gerald L.

    1974-01-01

    Birth order studies directly related to vocational interest were reviewed to discern support for certain theoretical susumptions: firstborns are more directing, controlling, and organizing than later borns and later borns are more sociable, empathic, and sympathetic than firstborns. The research was inconsistent, contradictory, and speculative.…

  14. Evaluating Vocational Programs: A Three Dimensional Model.

    Science.gov (United States)

    Rehman, Sharaf N.; Nejad, Mahmoud

    The traditional methods of assessing the academic programs in the liberal arts are inappropriate for evaluating vocational and technical programs. In traditional academic disciplines, assessment of instruction is conducted in two fashions: student evaluation at the end of a course and institutional assessment of its goals and mission. Because of…

  15. Vocational Teacher Stress and Internal Characteristics.

    Science.gov (United States)

    Adams, Elaine

    1999-01-01

    A survey of 235 Virginia vocational teachers examined 6 internal characteristics that would affect stress: role preparedness, job satisfaction, life satisfaction, illness symptoms, locus of control, and self-esteem. Role preparedness, illness symptoms, and self-esteem were significant contributors in explaining teacher stress. (SK)

  16. Vocational perspectives after spinal cord injury

    NARCIS (Netherlands)

    Schonherr, MC; Groothoff, JW; Mulder, GA; Eisma, WH; Schönherr, M.C.

    2005-01-01

    Objective: To give insight into the vocational situation several years after a traumatic spinal cord injury (SCI) and describe the personal experiences and unmet needs; to give an overview of health and functional status per type of SCI and their relationship with employment status. Design: Descript

  17. Agribusiness Management. The Connecticut Vocational Agriculture Curriculum.

    Science.gov (United States)

    EASTCONN Regional Educational Services Center, North Windham, CT.

    These materials in agribusiness management for the Connecticut Vocational Agriculture Curriculum were designed for use in the following areas: Animal Science; Plant Science; Agricultural Mechanics; and Natural Resources and Aquaculture. Each unit of this competency-based guide contains title of unit, unit length, grade level, objectives, teacher…

  18. Dental Assisting Course. Bilingual Vocational Instructional Materials.

    Science.gov (United States)

    Lopez-Cox, Guadalupe

    This course in dental assisting, one of a series of bilingual English-Spanish vocational education courses, is designed to prepare the student to assist the dentist at the chairside in the dental operatory, to perform reception and clerical functions, and to carry out selected dental laboratory work. The course covers an introduction to the…

  19. Special Education and Vocational Education Compatibility.

    Science.gov (United States)

    Yoshinaga, Myrtle E.; Kallman, James R.

    1977-01-01

    The differences in the developmental philosophies of vocational education personnel and special education personnel, and the effects of these differences on students, are discussed. The need to examine specific job skills, to work with groups and modify group-developed materials, and to look at individual students prescriptively are discussed.…

  20. Children's Vocational Development: A Research Rationale

    Science.gov (United States)

    Porfeli, Erik J.; Hartung, Paul J.; Vondracek, Fred W.

    2008-01-01

    Vocational development research and interventions have focused primarily on adolescents and young adults. The lack of attention to career development antecedents in children has led to a serious neglect of this period of life when the foundation is laid for career choices and outcomes in later life. A harmful by-product is the frequent preclusion…

  1. Integrating Computer Literacy into the Vocational Curriculum.

    Science.gov (United States)

    Whatley, Myra N.

    In the summer of 1983, a centralized microcomputer laboratory was established on the Sarasota County Vocational Technical Center campus. Computers (IBM PCs, APPLE IIes, and TRS-80s) were installed and the teacher who had written the program proposal was chosen to teach the course of instruction to be offered by the laboratory. When classes began…

  2. Research and Development Needs of Vocational Education.

    Science.gov (United States)

    Lewis, Morgan V., Ed.

    Intended to provide information on applied research and development (R&D) priorities in vocational education and on the type of R&D required for each need, this report is divided into (1) an introduction to the problem and procedures, (2) a content analysis of selected documents, and (3) background papers for selected need areas. Chapter 1…

  3. Anticipating Future Influences on Vocational Education.

    Science.gov (United States)

    Lewis, Morgan V.; And Others

    In a study conducted to identify the major forces that appear likely to influence vocational education in the next three to five years, a general model or conceptual framework was developed and modified by suggestions from a panel of experts. The following were identified as major influences: (1) a gradual decrease in the number of secondary…

  4. Cosmetology Reading Strategies. 1980 Vocational Reading Series.

    Science.gov (United States)

    Thornton, L. Jay; And Others

    Cosmetology Reading Strategies is one of five instructional guides in the Reading Strategies in Vocational Education Series. Developed to assist teachers working with students considered disadvantaged because of reading deficiency, the guide contains several strategies, suitable for adaptation, specifically related to cosmetology instruction. Each…

  5. Integrating Science with Technical and Vocational Areas.

    Science.gov (United States)

    Snyder, Larry; Shreckengast, Craig

    This guide presents learning activities and lesson plans that integrate science with technical and vocational areas. Activities and plans are organized under broad headings such as Environmental Science and Acid Rain Research; Criminal Justice, Chemistry, and Narcotics; Children's Education and Services; Cosmetology; and Health Professions.…

  6. Revised Recommendation Concerning Technical and Vocational Education.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Paris (France).

    The UNESCO (United Nations Education, Scientific, and Cultural Organization) revised recommendation setting forth general principles, goals, and guidelines concerning technical and vocational education (adopted by the General Conference at its 18th session in Paris, 19 November 1974) is presented under the following headings: (1) Technical and…

  7. Vocational Education and Learning in Higher Education

    Science.gov (United States)

    de Carvalho, Cynthia Paes

    2012-01-01

    This article discusses the relationship of students with learning and the university in the context of current challenges to vocational education and economic development. Inspired by the research of Pierre Bourdieu, this case study focuses on the relationship of students to learning and the university in Brazil. The survey gathered elements that…

  8. English Higher Education and Its Vocational Zones

    Science.gov (United States)

    Parry, Gareth

    2015-01-01

    Distinctions between academic, vocational and professional education inform but do not define the divisions of English higher education. Nevertheless, there are zones where courses, qualifications and institutions are specifically oriented to the world of work. These include most short-cycle higher education, large parts of undergraduate and…

  9. High Technology in the Vocational Agriculture Classroom.

    Science.gov (United States)

    Camp, William G.

    While many aspects of high technology may be directly applicable in the vocational agricultural classroom, the primary thrust of high technology into such programs, at least in the short range, will be centered around the microcomputer. Because of its cost and availability, the microcomputer will continue to play an ever increasing role in…

  10. VR closure rates for two vocational models.

    Science.gov (United States)

    Fraser, Virginia V; Jones, Amanda M; Frounfelker, Rochelle; Harding, Brian; Hardin, Teresa; Bond, Gary R

    2008-01-01

    The Individual Placement and Support (IPS) model of supported employment is an evidence-based practice for individuals with psychiatric disabilities. To be financially viable, IPS programs require funding from the state-federal vocational rehabilitation (VR) system. However, some observers have questioned the compatibility of IPS and the VR system. Using a randomized controlled trial comparing IPS to a well-established vocational program called the Diversified Placement Approach (DPA), we examined rates of VR sponsorship and successful VR closures. We also describe the establishment of an active collaboration between a psychiatric rehabilitation agency and the state VR system to facilitate rapid VR sponsorship for IPS clients. Both IPS and DPA achieved a 44% rate of VR Status 26 closure when considering all clients entering the study. IPS and DPA averaged similar amount of time to achieve VR sponsorship. Time from vocational program entry to Status 26 was 51 days longer on average for IPS. Even though several IPS principles seem to run counter to VR practices, such as zero exclusion and rapid job search, we found IPS closure rates comparable to those for DPA, a vocational model that screens for readiness, provides prevocational preparation, and extensively uses agency-run businesses.

  11. Secondary Vocational Horticulture Programs--An Assessment.

    Science.gov (United States)

    Burnett, Michael F.; Smith, Charles W.

    1983-01-01

    The objectives of the study were to determine characteristics of secondary horticulture teachers, the structure of horticulture departments, funding sources, nature and scope of facilities, types of supervised occupational experience programs in which horticulture students participated, and curriculum characteristics of vocational horticulture…

  12. Commercial Refrigeration Technology. Florida Vocational Program Guide.

    Science.gov (United States)

    University of South Florida, Tampa. Dept. of Adult and Vocational Education.

    The program guide for commercial refrigeration technology courses in Florida identifies primary considerations for the organization, operation, and evaluation of a vocational education program. Following an occupational description for the job title for refrigeration mechanic, and its Dictionary of Occupational Titles code, are six sections…

  13. Vocational Choice: A Decision Making Perspective

    Science.gov (United States)

    Sauermann, Henry

    2005-01-01

    We propose a model of vocational choice that can be used for analyzing and guiding the decision processes underlying career and job choices. Our model is based on research in behavioral decision making (BDM), in particular the choice goals framework developed by Bettman, Luce, and Payne (1998). The basic model involves two major processes. First,…

  14. FORCE Containing Vocational Training in Europe. Vademecum.

    Science.gov (United States)

    FORCE Technical Assistance Office, Brussels (Belgium).

    The aim of the FORCE program is to promote the continuing vocational training of workers in Member States of the European Community (EC). FORCE offers assistance at national and EC levels in implementing measures to enhance both the development and quality of continuing training. Measures at the national level comprise the preparation of regular…

  15. Decision-Making Style and Vocational Maturity.

    Science.gov (United States)

    Phillips, Susan D.; Strohmer, Douglas C.

    1982-01-01

    Examined the relationship between decision-making style, scholastic achievement, and vocational maturity for college students (N=64). Results did not support the hypothesized relationship between rationality and attitudinal and cognitive maturity. Scholastic achievement and lack of dependent decision style were found to be moderately predictive of…

  16. Parental Influence on College and Vocational Decisions

    Science.gov (United States)

    Venerable, Wilbur R.

    1974-01-01

    Reports on a survey made of 300 freshmen college students on the amount of perceived parental influence on college and vocational choice. Although students surveyed indicated that they made their own decisions, most said that they sought parental advice on important issues. (Author/PC)

  17. Nepal: Vocational Educator's Role in Elementary Education

    Science.gov (United States)

    Stitt, Thomas R.

    1974-01-01

    The innovative vocational education program of the elementary grades in the developing country of Nepal focuses on "self-help" within the "practical arts" (agriculture, trade and industrial, and home science fields) and emphasizes application of subject matter to students' daily lives, integration of skills into the curriculum, and occupational…

  18. Desiderata: Towards Indigenous Models of Vocational Psychology

    Science.gov (United States)

    Leong, Frederick T. L.; Pearce, Marina

    2011-01-01

    As a result of a relative lack of cross-cultural validity in most current (Western) psychological models, indigenous models of psychology have recently become a popular approach for understanding behaviour in specific cultures. Such models would be valuable to vocational psychology research with culturally diverse populations. Problems facing…

  19. Desiderata: Towards Indigenous Models of Vocational Psychology

    Science.gov (United States)

    Leong, Frederick T. L.; Pearce, Marina

    2011-01-01

    As a result of a relative lack of cross-cultural validity in most current (Western) psychological models, indigenous models of psychology have recently become a popular approach for understanding behaviour in specific cultures. Such models would be valuable to vocational psychology research with culturally diverse populations. Problems facing…

  20. Vocational Education Curriculum Development. Final Report.

    Science.gov (United States)

    Schlichting, Harley

    A project was conducted at the University of Missouri-Columbia to develop, revise, and complete curriculum materials for nine secondary vocational education programs and specialized areas: forestry, advanced crops, clerical/secretarial, junior high home economics, textile fibers, drafting and design, metals, licensed practical nursing/advanced…

  1. Vocational and Technical Education Reform in Turkey

    Science.gov (United States)

    Kilic, Abdurrahman

    2006-01-01

    Turkey is a country where individual rights and freedom of people are improving. It is known that a free market economy is in its infancy. There is a strong relationship between developed human resources and the production sector. In this sense, vocational and technical education is very important. It cannot be said that the efforts for…

  2. Developing Vocational Competences during Secondary School?

    Science.gov (United States)

    Behle, Heike

    2017-01-01

    Purpose: Using the example of an amalgamated secondary school qualification (International Baccalaureate Career-related Programme--IBCP), in which both vocational education and training (VET) and academic subjects are taught, the paper aims to discuss the use of skills and knowledge gained during the IBCP for post-secondary school activities.…

  3. Brain Damage in Deaf Vocational Rehabilitation Clients.

    Science.gov (United States)

    Getz, Marc; Vernon, McCay

    1986-01-01

    Screening of 54 deaf vocational clients by the Bender-Gestalt and other tests indicated the likely presence of significantly more brain damage than among the hearing population with a particularly high correlation between low IQ and brain damage in the deaf population. (DB)

  4. Vocational Education and Learning in Higher Education

    Science.gov (United States)

    de Carvalho, Cynthia Paes

    2012-01-01

    This article discusses the relationship of students with learning and the university in the context of current challenges to vocational education and economic development. Inspired by the research of Pierre Bourdieu, this case study focuses on the relationship of students to learning and the university in Brazil. The survey gathered elements that…

  5. 77 FR 43560 - American Indian Vocational Rehabilitation Services Program; Proposed Waivers and Extensions of...

    Science.gov (United States)

    2012-07-25

    ... CFR Chapter III American Indian Vocational Rehabilitation Services Program; Proposed Waivers and...) published on March 14, 2007 (72 FR 11851), provide vocational rehabilitation services to American Indians... projects initially funded in fiscal year (FY) 2007 under the American Indian Vocational...

  6. Clean Energy Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    For the past several years, the IEA and others have been calling for a clean energy revolution to achieve global energy security, economic growth and climate change goals. This report analyses for the first time progress in global clean energy technology deployment against the pathways that are needed to achieve these goals. It provides an overview of technology deployment status, key policy developments and public spending on RDD&D of clean energy technologies.

  7. 植物脂肪酸及其衍生物防御信号研究进展%Progress on Fatty Acids and Their Derivatives-mediated Signaling Pathways in Plant Disease Resistance

    Institute of Scientific and Technical Information of China (English)

    汤丽川; 赵永亮; 毛龙; 李爱丽

    2012-01-01

    植物由于不能移动而发展了复杂而精密的抗病系统.近年来,人们发现作为细胞膜组分的脂肪酸在植物的各种抗病机制中发挥着举足轻重的作用.脂肪酸及其衍生物不仅参与植物基础免疫和系统免疫,还参与经典抗病基因(R基因)介导的抗病过程.目前,已发现许多与脂肪酸(尤其是16碳和18碳脂肪酸及其衍生物)代谢相关的突变体,对这些突变体抗病性政变的分子机制研究成为植物抗病领域研究热点之一.本文综述了脂肪酸及其衍生物在植物防御信号转导中的最新研究进展,旨在为植物抗病遗传育种研究提供新的参考.%The sessile plants have developed complicated but sophisticated disease resistance systems. In recent years,fatty acids (FAs),the common cell membrane components,have been found to play important signaling roles in various disease resistance mechanisms. Fatty acids,especially 16- and 18-carbon derivatives,not only participate in both plant basal and systemic immunity,but also are required for the classical R gene mediated resistance mechanism. To date,many mutants have been found to be involved in the metabolism of fatty acid (especially the fatty acids having 16 or 18 carbons,or their derivatives). And the mechanisms about how these mutants changing their resistance to diseases have become a hotspot in the field of plant pathogen defense. This article has reviewed the recent progresses on how the fatty acid and its derivatives acting in the signaling pathways of plant defense,and aimed to contribute to the breeding of disease-resistant plants.

  8. Research progress in multiple regulation pathways of STAT3 in cancer%STAT3的多重调控方式在肿瘤中的研究进展

    Institute of Scientific and Technical Information of China (English)

    杨毅; 袁杰; 牛瑞芳

    2016-01-01

    The activation of the proto-oncogene STAT3 is strongly controlled under physiological conditions. However, obtained evi-dence revealed that STAT3 is persistently activated in cancer cells and contributes to cancer initiation and progression. Studies demon-strated the various functions of activated STAT3 in promoting cancer development and aggravation, including cancer cell proliferation, invasion and metastasis, drug resistance, epithelial-mesenchymal transition, regulation of the tumor microenvironment, and promo-tion of the self-renewal and differentiation of cancer stem cells. Canonically, STAT3 is regulated by signaling pathways mediated by cy-tokines and growth factors. Many studies determined that STAT3 was also regulated by G protein-coupled receptors, cadherin engage-ment, Toll-like receptors, microRNA, and acetylation. We summarized the recent developments in the research on the regulation of STAT3 activation.%生理情况下原癌基因信号传导及转录激活子3(signal transducer and activator of transcription-3,STAT3)的激活受到严格的调控。然而,大量证据表明,STAT3在许多肿瘤细胞中存在持续激活,并在肿瘤的起始与进展中发挥重要作用。目前的研究发现,活化的STAT3能够通过多种方式促进肿瘤的进展,如促进肿瘤细胞的增殖、侵袭转移、耐药、上皮-间质转化、调节肿瘤微环境、促进肿瘤干细胞的更新与分化等。STAT3的激活除了受传统的细胞因子和生长因子信号通路的调控以外,大量的证据显示G-蛋白偶联受体、钙黏素、Toll样受体、miRNA以及乙酰化修饰等也在STAT3活化过程中发挥了重要作用。本文主要针对肿瘤细胞中调控STAT3活化的途径进行综述。

  9. he (UnAttractiveness of Vocational and Technical Education: Theoretical Background

    Directory of Open Access Journals (Sweden)

    Miha Lovšin

    2014-03-01

    Full Text Available This paper considers the problem of the lack of attractiveness of vocational and technical education via a review of legislation on counselling practices, implementing documents, and the social factors by means of which the education system can influence the individual’s decision. It is apparent that legislation regulating the organisation and content of career counselling services in educational sector is inadequate. The organisation of career counselling at the level of implementation is also inadequate. Counsellors advise individuals on the basis of their academic results and the results of aptitude tests. Counselling practices deriving from theories that place career planning and management skills in the foreground are more rarely represented. Theories that treat career decisions as a social process show that at the level of the student population the choice of the type of school is a rational decision based primarily on the economic position and level of education to which a specific educational pathway is generally supposed to lead. The lower attractiveness of vocational and technical education coincides with the fact that representatives of lower social classes have a weaker economic position and more frequently have vocational and technical education qualifications than representatives of higher social classes. Nevertheless, the trend of high unemployment among young people with academic qualifications, which opposite of the traditional situation, indicates that it will be necessary to include career planning and management skills in the educational contents of institutionalised and formal education as a whole.

  10. Vocational education and training (VET) as a career path for young people

    DEFF Research Database (Denmark)

    Kersh, Natasha; Juul, Ida

    This paper aims to contribute to a better understanding of the issues of perceptions and motivations of young people towards Vocational Education and Training (VET) in England and Denmark. It specifically focuses on factors that facilitate their either positive or negative attitudes. Complex...... interdependencies between the labour market, young people’s occupational choices, and career routes have been a focus of policy concern, discussions and research across European countries. VET, as a pathway for young people to a career, has been and continues to be open to wide interpretation and debate...

  11. Research and Practice of“Vocational Class”Teaching Mode

    Institute of Scientific and Technical Information of China (English)

    Xing Linlin; Jia Zhuli

    2015-01-01

    Vocational class” teaching mode is based on vocational ability training of students as the goal to develop target-oriented approach of the teaching reform method; it is a new teaching method.This mode is the integration of teaching,learning and doing in class; it is the typical vocational tasks mode of teaching methods.Teaching process imitates the office scene and the actual workingprocess.

  12. Research and Practice of “Vocational Class” Teaching Mode

    Institute of Scientific and Technical Information of China (English)

    邢琳琳; 贾柱立

    2015-01-01

    "Vocational class" teaching mode is based on vocational ability training of students as the goal to develop target-oriented approach of the teaching reform method; it is a new teaching method.This mode is the integration of teaching,learning and doing in class; it is the typical vocational tasks mode of teaching methods.Teaching process imitates the office scene and the actual working process.

  13. Research progress of the molecular signal pathway in the prevention and treatment of osteoporosis%分子信号通路在骨质疏松防治中的研究进展

    Institute of Scientific and Technical Information of China (English)

    曾羿(综述); 沈彬(审校)

    2014-01-01

    大量骨质疏松的分子水平研究发现,骨代谢过程中存在受多种调节因子调控的信号通路,如OPG/RANKL/RANKL通路、Wnt/β-catenin通路、组织蛋白酶K通路和骨形成蛋白通路。通过研究上述分子信号通路,明确各信号通路中的重要靶点,通过抑制或促进各靶点蛋白的合成和分泌,达到抑制骨吸收和促进骨形成的目的,从而对骨质疏松症的防治开辟新的方向。%Abundant researches of osteoporosis at molecular level reveal that the bone metabolism is regulated by various molecular signal pathways, including OPG/RANKL/RANKL pathway, Wnt/β-catenin pathway, Cathepsin K pathway, and BMP pathway. Through the researches of these signal pathways, we can identify the important target in each signal pathway.By inhibiting or promoting the synthesis and secretion of each target protein, we can inhibit bone resorption and promot bone formation, finally developing a new strategy in the prevention and treatment of osteoporosis.

  14. Investigation of English Learning Motivation in Higher Vocational Institutes

    Institute of Scientific and Technical Information of China (English)

    张明香

    2013-01-01

      Since China joined WTO in 2001, there has been an increasing demand for professional technicians for the development and construction of economy. English being a tool for inter-countries communication has drawn great attention in higher vocational education. As for higher vocational institute students to learn English well, learning motivation plays a vital part. Therefore, this es⁃say is written to analyze the features of the main types of motivation held by the higher vocational institute students and accordingly offer some suggestions for teachers to improve their teaching quality and efficiency in higher vocational institute.

  15. Theory of secondary vocational English project teaching method

    Institute of Scientific and Technical Information of China (English)

    张梅

    2016-01-01

    Under the impetus of the rapid development of science and technology and economy,Social productivity level and greatly enhance people's quality of life,education level also got further development.Under the influence of the globalization development trend,English gradually become the most widely used foreign language of people daily life. Secondary vocational English is a public basic course of secondary vocational school students, as an important part of secondary vocational students training plan, has received the widespread attention.In this study, secondary vocational English project teaching method is briefly discussed.

  16. Reforming vocational didactics by implementing a new VET teacher education

    DEFF Research Database (Denmark)

    Duch, Henriette; Andreasen, Karen Egedal

    2015-01-01

    from backgrounds with no tradition for education. Despite historical changes, the education as vocational college teacher also struggles with the interplay between theory and practice in the program and great diversity among vocational college teachers. Based on empirical data from focus group...... interviews with students from the Diploma of Vocational Pedagogy program and concepts developed by Bernstein and Bourdieu, the article analyzes how these aspects might affect the development of new vocational didactics. We know that it is not easy to change the culture of educational institutions......, and the analysis uncovers several factors that are expected to hamper the development processes....

  17. Progress Report

    DEFF Research Database (Denmark)

    Duer, Karsten

    1999-01-01

    Progress report describing the work carried out by the Danish participant in the ALTSET project in the period January 1999 to July 1999.......Progress report describing the work carried out by the Danish participant in the ALTSET project in the period January 1999 to July 1999....

  18. Pathways to Employment and Quality of Life for Apprenticeship and Traineeship Graduates with Disabilities

    Science.gov (United States)

    Cocks, Errol; Thoresen, Stian H.; Lee, Elinda Ai Lim

    2015-01-01

    People with disabilities have low participation rates in employment and vocational education and training. Thirty adults with disabilities were sampled from an Australian longitudinal study of economic and social outcomes achieved by graduate apprentices and trainees. Participants were surveyed and interviewed to identify pathways from high school…

  19. The importance of vocational ethics in paramedic education, vocational ethics course for paramedics

    Directory of Open Access Journals (Sweden)

    Pakdemirli Ahu

    2016-01-01

    Full Text Available Ethics are rules of behaviors which morally good or bad. Bioethics is the study of ethics about by advances in biology and medicine. Health care providers should have knowledge about health professional ethics principles, public officials’ ethical behavior principles and ethical principles concerned about other legislation. They should find the required information to make logical, objective and accurate decisions where they may face with ethical problems in their professional life. Unfortunately in our country there isn’t any special vocational ethics course designed for paramedics. Our aim is to design a Vocational Ethics Course for Paramedics which includes all issues of bioethics.

  20. The Research of Mathematical Modeling Thought in Higher Vocational Mathematics%数学建模思想在高职数学中的渗透研究

    Institute of Scientific and Technical Information of China (English)

    许蕊

    2016-01-01

    随着社会的发展和科学的进步,高职教育受到更多人的关注,在高职教学中数学更是教学任务中的重要一项。在高职数学教学中将数学建模思想渗透其中,能够更好地帮助提升高职数学教学质量,同时也符合现在国家对高职教育的培养要求和目标要求。%With the development of society and the progress of science, higher vocational education has been concerned by more people. In the teaching of higher vocational education, mathematics is an important task. In the higher vocational mathematics teaching, mathematical modeling thought infiltration among them, can better help to improve the quality of higher vocational mathematics teaching, but also in line with the current state of higher vocational education training requirements and objectives.

  1. Molecular pathways

    DEFF Research Database (Denmark)

    Cox, Thomas R; Erler, Janine Terra

    2014-01-01

    that 45% of deaths in the developed world are linked to fibrotic disease. Fibrosis and cancer are known to be inextricably linked; however, we are only just beginning to understand the common and overlapping molecular pathways between the two. Here, we discuss what is known about the intersection...... of fibrosis and cancer, with a focus on cancer metastasis, and highlight some of the exciting new potential clinical targets that are emerging from analysis of the molecular pathways associated with these two devastating diseases. Clin Cancer Res; 20(14); 3637-43. ©2014 AACR....

  2. Research progress of the roles of Notch signaling pathway in craniomaxillofacial intramembranous ossification%Notch信号通路调控颅颌面膜内成骨研究进展

    Institute of Scientific and Technical Information of China (English)

    谭宇; 杨秩; 房兵

    2013-01-01

    Intramembranous ossification is regulated and affected by many signal pathways. Notch signaling pathway plays important roles in bone formation. Abnormal Notch signaling pathway leads to the bone deformities. Understanding the function of Notch signaling pathway in osteogenesis reveals mechanisms of various bone deformities,especially crani-omaxillofacial bone deformities. This article focuses on functions of Notch signaling pathway and its regulation on osteo-genesis.%膜内成骨是骨骼形成的重要方式,其受多条信号通路的调控,Notch信号通路是其中重要的一条。异常的Notch信号通路影响骨骼的形成。深入探讨Notch信号通路在膜内成骨中的作用机制,有利于揭示临床多种骨骼畸形,尤其是颅颌面骨发育异常的发生机制,提供新的治疗靶标。本文概述Notch信号通路对膜内成骨过程的调控。

  3. The Vocational-Liberal Arts Controversy: Looking Backwards.

    Science.gov (United States)

    Miles, Sue L.

    The liberal arts-vocational education controversy is examined in this article through a series of fictitious letters based on historical facts that present the thoughts of key educational personalities regarding the community college's role in providing vocational education and liberal arts education. Part I, which takes the form of a letter and…

  4. Happy Objects, Happy Men? Affect and Materiality in Vocational Training

    Science.gov (United States)

    Åberg, Magnus; Hedlin, Maria

    2015-01-01

    This article investigates the prevailing social inertia of vocational training. Previous research indicates that gendered social norms contribute to sustaining gender segregation. Few studies, however, have paid attention to how the interplay of emotional and material factors impact on gender norms in vocational training. The article builds on an…

  5. Vocational Behavior and Career Development, 1983: A Review.

    Science.gov (United States)

    Tinsley, Howard E. A.; Heesacker, Martin

    1984-01-01

    Reviews the literature related to vocational behavior and career development published during 1983, including 445 articles in 42 journals. The review is organized around issues pertinent to the counseling psychology perspective (career development, vocational choice, assessment, intervention) and the industrial/organizational psychology…

  6. Discovery learning and learner autonomy development in secondary vocational school

    Institute of Scientific and Technical Information of China (English)

    刘芩利

    2015-01-01

    It is imperative to cultivate learner autonomy in secondary vocational school and discovery learning is a good choice.The author reviews the definition and principle of discovery learning and learning autonomy,concludes the adaptation of discovery learning from characteristics of vocational students,andfinally illustrates an example in teaching.

  7. Vocational Training Course to TC Secretary-generals

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Up to September 2003, three vocational training courses to the secretary-generals of standardization technical committees had already been conducted by Standardization Administration of China (SAC) to meet the reforming and developing requirements in standardization work, and enhance the vocational levels as well as the managing skills of the TC secretary-generals.

  8. Operational Model for Career Development and Vocational Preparation. Final Report.

    Science.gov (United States)

    Upton, Anne L.; Barrett, Samuel L.

    Three California State Department units (vocational education, pupil personnel services, and career education) and two school districts (Fremont Unified and Huntington Beach Union High) established a consortium to develop demonstration sites for model career development and vocational preparation systems and staff development programs. The…

  9. Industrial Machinery Maintenance and Repair. Florida Vocational Program Guide.

    Science.gov (United States)

    University of South Florida, Tampa. Dept. of Adult and Vocational Education.

    This vocational program guide is intended to assist in the organization, operation, and evaluation of a program in industrial machinery maintenance and repair in school districts, area vocational centers, and community colleges. The following topics are covered: job duties of millwrights, maintenance mechanics, and machinery erectors; program…

  10. The Quality Assistance Plan for Vocational Education in Illinois.

    Science.gov (United States)

    McCormick, Fred C.; McCormick, Eileen R.

    The Quality Assistance Plan (QAP) for Vocational Education in Illinois is a state-funded program for locally initiated, developed, implemented, and evaluated projects that was begun in Fiscal Year 1982. Its purpose is to build the capacity, in each educational setting, for the improvement of vocational education programs. That improvement should…

  11. Predictive Value and Psychological Meaning of Vocational Aspirations

    Science.gov (United States)

    Holland, John L.; Gottfredson, Gary D.

    1975-01-01

    The psychological meaning and predictive value of a person's vocational aspirations were examined by applying Holland's typology to the vocational aspirations of high school juniors (N=140), and a second sample of college students studied over a one-year interval (N-624). (Author)

  12. A Theory Ridden, Computerless, Impersonal Vocational Guidance System

    Science.gov (United States)

    Holland, John L.

    1971-01-01

    The Self-Directed Search for educational and Vocational Planning is a self-administered, self-scored, and self-interpreted vocational counseling tool. It is inexpensive, practical, and has a high degree of scientific validity and client effectiveness. The SDS is based on Holland's theory of personality types. (Author)

  13. Vocational Training Today: The Changing Relationship between Training and Employment.

    Science.gov (United States)

    Ducray, Gabriel

    1979-01-01

    Focusing on the changing relationship between training and employment, this article discusses (1) limitations of traditional vocational training policies, (2) the relationship between training and employment today, (3) changes in skills and the effects of structural factors on the employment situation, and (4) a modern vocational training policy.…

  14. Should I Take French, Physics, or Vocational Agriculture?

    Science.gov (United States)

    Hamilton, William; Goecker, Allan

    1974-01-01

    Studies at the Purdue School of Agriculture indicated students who had completed high school vocational agriculture were more likely to complete requirements for a baccalaureate degree in agriculture than those not having vocational agriculture. Agriculture college-bound students should emphasize agriculture, biology, chemistry, mathematics, and…

  15. Happy Objects, Happy Men? Affect and Materiality in Vocational Training

    Science.gov (United States)

    Åberg, Magnus; Hedlin, Maria

    2015-01-01

    This article investigates the prevailing social inertia of vocational training. Previous research indicates that gendered social norms contribute to sustaining gender segregation. Few studies, however, have paid attention to how the interplay of emotional and material factors impact on gender norms in vocational training. The article builds on an…

  16. Nursing/LVN Course. Bilingual Vocational Instructional Materials.

    Science.gov (United States)

    Lopez-Cox, Guadalupe

    This course in licensed vocational nursing, one of a series of bilingual English-Spanish vocational education courses, is designed to teach basic nursing principles needed by nurses' aides to do nursing procedures and skills in the different health care institutions. It covers many areas, including the following: the health care system, personal…

  17. Multiple Learning Strategies Project. Dietetic Assistant. [Regular Vocational. Vol. 1.

    Science.gov (United States)

    Noffze, Elaine; And Others

    This instructional package is one of two designed for regular vocational students on the vocational area of dietetic assistant. The eighty-nine learning modules are organized into three units: nutrition; menu planning and food ordering; and housekeeping and safety. Each module includes these elements: a performance objective page telling what will…

  18. Incentive Styles, Asynchronous Online Discussion, and Vocational Training

    Science.gov (United States)

    Lin, Shinyi; Chiu, Chou-Kang

    2008-01-01

    Vocational education and training (VET) is intended to prepare adult learners for careers that are based on practical activities. With the underlying constructivist andragogy, this study intended to examine the effects of computer-mediated group collaboration in vocational education, and how that affects the associated learning outcomes. For…

  19. Learning in School and Out--General vs. Vocational Education.

    Science.gov (United States)

    Achtenhagen, Frank

    The adequate way to discuss problems of vocational education more generally is that taken by Resnick (1987). She feels that the relationship between general and vocational education, and their respective and common aims, problems, and restrictions, must be outlined primarily substantially and not only organizationally. Resnick tries to combine the…

  20. 20 CFR 405.10 - Medical and Vocational Expert System.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Medical and Vocational Expert System. 405.10 Section 405.10 Employees' Benefits SOCIAL SECURITY ADMINISTRATION ADMINISTRATIVE REVIEW PROCESS FOR ADJUDICATING INITIAL DISABILITY CLAIMS Introduction, General Description, and Definitions § 405.10 Medical and Vocational Expert System. (a) General....

  1. Multiple Learning Strategies Project. Medical Assistant. [Regular Vocational. Vol. 1.

    Science.gov (United States)

    Varney, Beverly; And Others

    This instructional package, one of four designed for regular vocational students, focuses on the vocational area of medical assistant. Contained in this document are twenty-six learning modules organized into three units: language; receptioning; and asepsis. Each module includes these elements: a performance objective page telling what will be…

  2. Collaborative learning in a culturally diverse secondary vocational education

    NARCIS (Netherlands)

    Drs. Kennedy Aquilino Tielman; Prof. dr. Perry den Brok; Dr. Rutger van de Sande; Dr. S. Bolhuis

    2010-01-01

    Collaborative learning in a culturally diverse secondary vocational education. By K. Tielman (Fontys), P. den Brok (ESoE), S. Bolhuis (Fontys) and R. van de Sande (Fontys) This contribution discusses a descriptive study on the experiences of students and teachers in secondary vocational education

  3. Non-Wage Benefits of Vocational Training: Employability and Mobility.

    Science.gov (United States)

    Bowlby, Roger L.; Schriver, William R.

    In order to investigate the effects of vocational training on labor force participation and unemployment, the researchers compared an experimental group of Tennessee Area Vocational-Technical School (AVTS) graduates with an individually matched control group. On the basis of data collected by questionnaire, the report concluded that vocationally…

  4. An Analysis of Differential Benefits from Vocational Training. Final Report.

    Science.gov (United States)

    Schriver, William R.; Bowlby, Roger L.

    The objectives of this study were to find out how the characteristics of students and their training affect the rate of return to investment in vocational training, how they affect the earnings of trainees, and how vocational training influences the distribution of income among educational groups. The data were collected in a previous study and…

  5. The vocational education and training system in Denmark

    DEFF Research Database (Denmark)

    Cort, Pia; Wiborg, Susanne

    2009-01-01

    Analysis of developments in vocational education and training systems in Australia, Canada, Denmark, France, Germany, Korea, Mexico, Morocco, the UK and the US.......Analysis of developments in vocational education and training systems in Australia, Canada, Denmark, France, Germany, Korea, Mexico, Morocco, the UK and the US....

  6. Interdisciplinarity in Vocational Guidance: An Action Theory Perspective

    Science.gov (United States)

    Valach, Ladislav; Young, Richard A.

    2009-01-01

    In addressing the issue of interdisciplinary research in vocational guidance, twelve propositions important for understanding the vocational guidance process as joint, goal-directed action are presented. They address the encounter between client and counsellor leading to relational ethics, the relevance of everyday action theory and methods for…

  7. The vocational education and training system in Denmark

    DEFF Research Database (Denmark)

    Cort, Pia; Wiborg, Susanne

    2009-01-01

    Analysis of developments in vocational education and training systems in Australia, Canada, Denmark, France, Germany, Korea, Mexico, Morocco, the UK and the US.......Analysis of developments in vocational education and training systems in Australia, Canada, Denmark, France, Germany, Korea, Mexico, Morocco, the UK and the US....

  8. Discovery learning and learner autonomy development in secondary vocational school

    Institute of Scientific and Technical Information of China (English)

    刘芩利

    2015-01-01

    It is imperative to cultivate learner autonomy in secondary vocational school and discovery learning is a good choice.The author reviews the definition and principle of discovery learning and learning autonomy,concludes the adaptation of discovery learning from characteristics of vocational students,and finally illustrates an example in teaching.

  9. Public Relations Handbook for Vocational Education in Large Cities.

    Science.gov (United States)

    Koble, Daniel E., Jr.; And Others

    Intended for use by urban vocational staff members who face public relations problems and need to facilitate the outreach process in their cities, this handbook contains guidelines for organizing the public. First, Sanford's definition of public relations is outlined, followed by an explanation of why vocational education needs public relations.…

  10. Vocational Assessment and Work Preparation Centres for the Disabled.

    Science.gov (United States)

    International Labour Office, Geneva (Switzerland).

    The purpose of this manual is to provide a basic guide for governments and other organizations in developing countries who want to either establish vocational assessment and preparation centers or develop training facilities for disabled persons. Contents include: (1) Establishing a Vocational Assessment and Work Preparation Center, (2) Staffing…

  11. Vocational Hypothesis Testing in Career Decision-Making.

    Science.gov (United States)

    Blustein, David L.; Strohmer, Douglas C.

    1987-01-01

    Examined vocational hypothesis testing by applying Snyder's hypothesis-testing research paradigm to a vocational task in two experiments. Subjects (N=106) were asked to evaluate the appropriateness of a specific occupation for themselves. Subjects tended to exhibit confirmatory hypothesis-testing strategies when relevant occupations were…

  12. Developing Strategic Leadership for Administrators: Private Vocational College Study

    Science.gov (United States)

    Jumnongya, Areeya; Sirisuthi, Chaiyuth; Chansirisira, Pacharawit

    2015-01-01

    The purpose of this study is to study and define a number of factors measuring quality and efficiency in administrators of private vocational college, and to test and evaluate the efficiency of the strategic leadership program. Twelve factors and 83 indicators were identified as vital for strategic leadership for private vocational college…

  13. Vocational Education in Singapore: Meritocracy and Hidden Narratives

    Science.gov (United States)

    Chong, Terence

    2014-01-01

    This paper offers a broad overview of vocational education in Singapore. Looking at vocational education from Independence, it argues that the development of a skilled labour force was not only crucial in the age of globalisation and the dominance of multinational companies, but also an empirical litmus test of the newly elected post-colonial…

  14. Factors Influencing Assessment Quality in Higher Vocational Education

    Science.gov (United States)

    Baartman, Liesbeth; Gulikers, Judith; Dijkstra, Asha

    2013-01-01

    The development of assessments that are fit to assess professional competence in higher vocational education requires a reconsideration of assessment methods, quality criteria and (self)evaluation. This article examines the self-evaluations of nine courses of a large higher vocational education institute. Per course, 4-11 teachers and 3-10…

  15. Factors influencing assessment quality in higher vocational education

    NARCIS (Netherlands)

    Baartman, L.; Gulikers, J.T.M.; Dijkstra, A.

    2013-01-01

    The development of assessments that are fit to assess professional competence in higher vocational education requires a reconsideration of assessment methods, quality criteria and (self)evaluation. This article examines the self-evaluations of nine courses of a large higher vocational education inst

  16. Big Questions Facing Vocational Psychology: A Cognitive Information Processing Perspective

    Science.gov (United States)

    Reardon, Robert C.; Lenz, Janet G.; Sampson, James P., Jr.; Peterson, Gary W.

    2011-01-01

    This article draws upon the authors' experience in developing cognitive information processing theory in order to examine three important questions facing vocational psychology and assessment: (a) Where should new knowledge for vocational psychology come from? (b) How do career theories and research find their way into practice? and (c) What is…

  17. Learning in School and Out--General vs. Vocational Education.

    Science.gov (United States)

    Achtenhagen, Frank

    The adequate way to discuss problems of vocational education more generally is that taken by Resnick (1987). She feels that the relationship between general and vocational education, and their respective and common aims, problems, and restrictions, must be outlined primarily substantially and not only organizationally. Resnick tries to combine the…

  18. The Vocational Personality of School Psychologists in the United States

    Science.gov (United States)

    Toomey, Kristine D.; Levinson, Edward M.; Morrison, Takea J.

    2008-01-01

    This study represents the first empirical test of the vocational personality of US school psychologists. Specifically, we investigated the personality of school psychologists using Holland's (1997) well-researched theory of vocational personalities and work environments. The sample consisted of 241 randomly selected members of the National…

  19. Philosophical and Sociological Overview of Vocational Technical Education in Nigeria

    Science.gov (United States)

    Kennedy, Odu Oji

    2012-01-01

    Vocational Technical Education is any kind of education which has the main purpose of preparing one for employment in recognized occupation. The foundation of vocational technical education is based on philosophy which was mainly established for self-employment and self-reliance of the individual(s) who partake in it. Viewing the philosophy and…

  20. Affective Factors in Vocational College Students’English Learning

    Institute of Scientific and Technical Information of China (English)

    王琼

    2011-01-01

    This paper focuses on the vocational college students’ experiences in English learning, classroom activities, attitudes to their English learning and achievements. It aims to find out how to make use of their positive personal factors to improve their English achievement so that both vocational college teachers and students may gain some enlightenment from the study.

  1. The Vocational Personality of School Psychologists in the United States

    Science.gov (United States)

    Toomey, Kristine D.; Levinson, Edward M.; Morrison, Takea J.

    2008-01-01

    This study represents the first empirical test of the vocational personality of US school psychologists. Specifically, we investigated the personality of school psychologists using Holland's (1997) well-researched theory of vocational personalities and work environments. The sample consisted of 241 randomly selected members of the National…

  2. Vocational Education in Singapore: Meritocracy and Hidden Narratives

    Science.gov (United States)

    Chong, Terence

    2014-01-01

    This paper offers a broad overview of vocational education in Singapore. Looking at vocational education from Independence, it argues that the development of a skilled labour force was not only crucial in the age of globalisation and the dominance of multinational companies, but also an empirical litmus test of the newly elected post-colonial…

  3. Big Questions Facing Vocational Psychology: A Cognitive Information Processing Perspective

    Science.gov (United States)

    Reardon, Robert C.; Lenz, Janet G.; Sampson, James P., Jr.; Peterson, Gary W.

    2011-01-01

    This article draws upon the authors' experience in developing cognitive information processing theory in order to examine three important questions facing vocational psychology and assessment: (a) Where should new knowledge for vocational psychology come from? (b) How do career theories and research find their way into practice? and (c) What is…

  4. Linear Programming for Vocational Education Planning. Interim Report.

    Science.gov (United States)

    Young, Robert C.; And Others

    The purpose of the paper is to define for potential users of vocational education management information systems a quantitative analysis technique and its utilization to facilitate more effective planning of vocational education programs. Defining linear programming (LP) as a management technique used to solve complex resource allocation problems…

  5. Vocational Training in the Textiles and Clothing Industries in Greece.

    Science.gov (United States)

    Drimousis, I.; Zisimopoulos, A.

    This document examines the circumstances under which vocational training in Greece is provided for jobs in the textile and clothing industries. Its objective is to identify guidelines for vocational training for a skilled work force at regional and national levels and to contribute to job mobility between industries. Statistical data,…

  6. Progressive Business

    DEFF Research Database (Denmark)

    Christiansen, Christian O.

    2016-01-01

    Guest Post to the Society for U.S. Intellectual History Blog. Brief introduction to the book Progressive Business: An Intellectual History of the Role of Business in American Society, Oxford U.P., 2015.......Guest Post to the Society for U.S. Intellectual History Blog. Brief introduction to the book Progressive Business: An Intellectual History of the Role of Business in American Society, Oxford U.P., 2015....

  7. Validity of Vocational Aspirations and Interest Inventories: Extended, Replicated, and Reinterpreted.

    Science.gov (United States)

    Holland, John L.; And Others

    1990-01-01

    Found classified vocational aspirations of 467 male and 250 female Navy recruits superior to Vocational Preference Inventory (VPI). Predictions for subjects with coherent vocational aspirations were very predictive over short time interval. Hypothesized links between coherence of vocational aspirations and Identity Scale, NEO Personality Inventory…

  8. Vocational Education. Report by the Secretary of Education to the Congress, 1981.

    Science.gov (United States)

    Office of Vocational and Adult Education (ED), Washington, DC.

    This annual report provides an overview of the status of vocational education during school year 1980-81. It includes final data for school year 1979-80 obtained through the Vocational Education Data System (VEDS), the national vocational education reporting and accounting system. Part 1 of the report describes the status of vocational education…

  9. 34 CFR 427.1 - What is the Bilingual Vocational Training Program?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What is the Bilingual Vocational Training Program? 427...) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION BILINGUAL VOCATIONAL TRAINING PROGRAM... Program provides financial assistance for bilingual vocational education and training for limited...

  10. Energy and Power--Math. Haywood County's Vocational-Math-Science Curriculum Alignment Project.

    Science.gov (United States)

    Haywood County Consolidated Schools, Waynesville, NC.

    A curriculum alignment chart is presented that translates mathematics goals/indicators into related vocational skills for the energy and power course in the secondary vocational education curriculum. The chart contains three columns that correlate (1) vocational education performance indicators, (2) vocational education competency and mathematics…

  11. Activation of the miR-34a/SIRT1/p53 Signaling Pathway Contributes to the Progress of Liver Fibrosis via Inducing Apoptosis in Hepatocytes but Not in HSCs.

    Directory of Open Access Journals (Sweden)

    Xiao-Feng Tian

    Full Text Available Liver fibrosis results from a sustained wound healing response to chronic liver injury, and the activation of nonparenchymal hepatic stellate cells (HSCs is the pivotal process. MicroRNA-34a (miR-34a is the direct target gene of p53 and activates p53 through sirtuin 1 (SIRT1 simultaneously. The miR-34a/SIRT1/p53 signaling pathway thus forms a positive feedback loop wherein p53 induces miR-34a and miR-34a activates p53 by inhibiting SIRT1, playing an important role in cell proliferation and apoptosis. miR-34a expression has been found to be increased in animal models or in human patients with different liver diseases, including liver fibrosis. However, the exact role of this classical miR-34a/SIRT1/p53 signaling pathway in liver fibrosis remains unclear. In the present study, using a CCl4-induced rat liver fibrosis model, we found that the miR-34a/SIRT1/p53 signaling pathway was activated and could be inhibited by SIRT1 activator SRT1720. Further studies showed that the miR-34a/SIRT1/p53 signaling pathway was activated in hepatocytes but not in HSCs. The activation of this pathway in hepatocytes resulted in the apoptosis of hepatocytes and thus activated HSCs. Our data indicate that the miR-34a/SIRT1/p53 signaling pathway might be a promising therapeutic target for liver fibrosis.

  12. Research progress of Nrf2-ARE signaling pathway in mechanism of paraquat poisoning%Nrf2-ARE信号通路在百草枯中毒中的研究进展

    Institute of Scientific and Technical Information of China (English)

    曹俊; 文航华; 黄涵柽

    2016-01-01

    Paraquat is widely used as a herbicide in agriculture,especially in Asian countries.The prevalence of paraquat poisonings has increased strikingly in China.The high fatality of paraquat poisoning is due to inherent toxicity and the lack of effective treatments.However,the pathogenesis is still unclear.Nrf2/antioxidant-responseelement (ARE) signal pathway is vital in the regulation of cellular oxidative stress response,and play the important roles in the cellular protection.Here,we reviewed and summarized the recent publications related to the molecular mechanisms of paraquat poisoning,introduced the relationship between Nrf2-ARE signaling pathway and paraquat poisoning.

  13. On Improving Higher Vocational College Education Quality Assessment

    Science.gov (United States)

    Wu, Xiang; Chen, Yan; Zhang, Jie; Wang, Yi

    Teaching quality assessment is a judgment process by using the theory and technology of education evaluation system to test whether the process and result of teaching have got to a certain quality level. Many vocational schools have established teaching quality assessment systems of their own characteristics as the basic means to do self-examination and teaching behavior adjustment. Combined with the characteristics and requirements of the vocational education and by analyzing the problems exist in contemporary vocational school, form the perspective of the content, assessment criteria and feedback system of the teaching quality assessment to optimize the system, to complete the teaching quality information net and offer suggestions for feedback channels, to make the institutionalization, standardization of the vocational schools and indeed to make contribution for the overall improvement of the quality of vocational schools.

  14. A Portrait of Rural America: Conditions Affecting Vocational Education Policy. Vocational Education Study Publication No. 6.

    Science.gov (United States)

    Rosenfeld, Stuart

    The monograph is an attempt to describe conditions existing today in rural America that can affect the operation and impact of vocational education in rural areas and, thus, should exercise an influence on policy making. It identifies statistical patterns and characteristics common to rural areas, both within regions and those that cut across…

  15. The Reasons for the Interruption of Vocational Training in Estonian Vocational Schools

    Science.gov (United States)

    Beilmann, Mai; Espenberg, Kerly

    2016-01-01

    Dropping out of school before achieving any qualification is a serious problem both at an individual and societal level. This study provides an insight into the lives of young people who have dropped out or are at a risk of dropping out of vocational schools in Estonia and gives an overview of the reasons behind the interruption of their studies.…

  16. The Phoenix: Vocational Education and Training in Singapore. International Comparative Study of Leading Vocational Education Systems

    Science.gov (United States)

    Tucker, Marc S.

    2012-01-01

    This is the first in a series of reports from the Center on International Education Benchmarking (CIEB) exploring the leading vocational and technical education systems from around the world to draw out what makes these systems great and what other countries can learn from them. This first report was based on a visit of several days to Singapore…

  17. Trade and Technical. Volume II. Access Skills. Vocational Readiness Skills. Missouri LINC. Assessing Vocational Education.

    Science.gov (United States)

    Missouri Univ., Columbia. Dept. of Practical Arts and Vocational-Technical Education.

    This document contains trade and industrial occupations-related materials to help teachers and parents teach access skills to Missouri junior high and high school special needs students who want to pursue a vocational program in auto body repair, auto mechanics, building maintenance and custodial work, diesel mechanics, machinist, small engine…

  18. Re-Contextualizing Vocational Didactics in Norwegian Vocational Education and Training

    Science.gov (United States)

    Nore, Haege

    2015-01-01

    This article explores teachers and trainers didactical practices in different contexts in Norwegian VET: schools and workplaces. With the introduction of e-resources and e-portfolios in VET, learners as well as teachers and trainers experience a more hybrid learning-arena, which claims for a re-contextualization of vocational didactics as well as…

  19. Vocational Pedagogical Competencies of a Professor in the Secondary Vocational Education System: Approbation of Monitoring Model

    Science.gov (United States)

    Andryukhina, Lyudmila M.; Dneprov, Sergey ?.; Sumina, Tatyana G.; Zimina, Elena Yu.; Utkina, Svetlana N.; Mantulenko, Valentina V.

    2016-01-01

    The relevance of the researched issue is preconditioned by the strategic changes in the secondary vocational education system taking place not only in Russia, but also in the majority of industrially developed countries. Provision of the system with qualified pedagogical staff is the leading strategic objective of development of the secondary…

  20. The Model of Monitoring of Vocational Pedagogical Competences of Professors in Secondary Vocational Education

    Science.gov (United States)

    Andryukhina, Lyudmila M.; Dneprov, Sergey ?.; Sumina, Tatyana G.; Zimina, Elena Yu.; Utkina, Svetlana N.; Mantulenko, Valentina V.

    2016-01-01

    The relevance of the researched issue is preconditioned by the strategic changes in the secondary vocational education system taking place not only in Russia, but also in majority of industrially developed countries. Provision of the system with qualified pedagogical staff is the leading strategic objective of development of the secondary…

  1. Mindfulness, Therapy and Vocational Values: Exploring the Moral and Aesthetic Dimensions of Vocational Education and Training

    Science.gov (United States)

    Hyland, Terry

    2011-01-01

    The devaluation and debilitation of education in general and vocational education and training (VET) in particular has been explored and described in recent years by a wide range of critical commentators. Education stands in dire need of therapy, and this paper suggests a therapeutic process for rejuvenating and enhancing VET through attention to…

  2. World Wide Comparism of Technical and Vocational Education: Lessons for Nigerian Technical and Vocational Education Sector (I)

    Science.gov (United States)

    Ayeni, Abiodun Olumide

    2015-01-01

    This paper compared technical/vocational education in: Germany, Australia, Finland, Hong Kong, Hungary, India, Japan, South Korea, Mexico, and Nigeria, and found that technical/vocational education was given proper attention in countries considered except Nigeria, where it was handled with laissez faire attitude. Set-Up of Technical/Vocational…

  3. Challenges and Reforms in Vocational Education: Aspects of Inclusion and Exclusion. Studies in Vocational and Continuing Education, Volume 11

    Science.gov (United States)

    Stolz, Stefanie, Ed.; Gonon, Philipp, Ed.

    2012-01-01

    In this collected edition, globalization and its consequences on vocational education systems are described and, at the same time, combined with the question of whether new phenomena of inclusion but also of exclusion are produced. Inclusion and exclusion are differentiations that predominate in all kinds of (vocational education) systems,…

  4. Common Core Curriculum for Vocational Education. Category D: Administration and Supervision. D-1: Fiscal Management of a Vocational Education Program.

    Science.gov (United States)

    Bain, William

    This module on fiscal management of a vocational education program is one of a set of eight on administration and supervision and is part of a larger series of thirty-four modules constituting a core curriculum for use in the professional preparation of vocational educators in the areas of agricultural, business, home economics, and industrial…

  5. Training of Teachers/Trainers in Technical and Vocational Education. UNEVOC Studies in Technical and Vocational Education, Number 11.

    Science.gov (United States)

    United Nations Economic, Scientific, and Cultural Organization, Paris (France). Section for Technical and Vocational Education.

    This document contains nine papers about and from an international roundtable on the training of teachers in technical and vocational education. The first paper, a Final Report of the "International Round Table on Training of Teachers in Technical and Vocational Education (Curitiba, Brazil, 7-10 April 1997)," examines the following:…

  6. Study On Establishing National Standard Of Vocational Teachers’ Training In China

    Directory of Open Access Journals (Sweden)

    Qiding Yu

    2009-08-01

    Full Text Available Developing vocational education is an important strategy in current Chinese education. However, vocational teachers are in a shortage and there isn’t a sound system of training and cultivating these teachers. Especially, there hasn’t formed any effective standard of vocational teachers. These three factors are the main reasons to hinder the development and increase of its quality and level. Therefore, establishing national standard of vocational teacher training is becoming very necessary. In this paper the author explores the standard and system of vocational teacher training from two aspects, namely, grasping professional skills and professional teaching competence. National standard of vocational teacher training will become a basis for vocational teacher qualification. According to this standard, vocational teacher qualification curriculum will be built and implemented by vocational educational institutions. We will share our experiences and measures in building vocational teacher qualification system in China and explore some key issues.

  7. Vocational choices made by alumni of the Leadership Program for Veterinary Students at Cornell University

    Science.gov (United States)

    Fraser, David R.; Parker, John S. L.; McGregor, Douglas D.

    2017-01-01

    OBJECTIVE To compare vocational aspirations and outcomes of participants in the 10-week Leadership Program for Veterinary Students at Cornell University. DESIGN Survey. SAMPLE Veterinary students who participated in the program between 1990 and 2013. PROCEDURES Questionnaires that sought information about the career aspirations of participants at the beginning and end of the program were reviewed, along with records documenting the career progression of participants, audio recordings of interviews conducted with students, and notes of vocation-oriented counseling sessions held during each year’s program. RESULTS At the conclusion of the program, 143 of 174 (82%) participants indicated they were more likely than not to undertake research training after completing their veterinary degree, compared with 106 of 174 (61%) at the beginning. Participation also stimulated interest in residency training and industry, but did little to promote interest in careers in government or the military. The percentage of participants who indicated they were more likely than not to pursue additional training in private practice decreased from 97 of 174 (56%) at the beginning of the program to 75 of 174 (43%) at the end. Information on career progression was available for 391 individuals, of whom 177 (45%) were pursuing careers of the kind envisioned by the program. However, 189 (48%) participants had a career in general or specialty clinical practice. CONCLUSIONS AND CLINICAL RELEVANCE The Leadership Program appeared to have a short-term influence on careers anticipated by program participants. However, a substantial proportion pursued careers in clinical practice after graduation. PMID:27654162

  8. Vocational choices made by alumni of the Leadership Program for Veterinary Students at Cornell University.

    Science.gov (United States)

    Fraser, David R; Parker, John S L; McGregor, Douglas D

    2016-10-01

    OBJECTIVE To compare vocational aspirations and outcomes of participants in the 10-week Leadership Program for Veterinary Students at Cornell University. DESIGN Survey. SAMPLE Veterinary students who participated in the program between 1990 and 2013. PROCEDURES Questionnaires that sought information about the career aspirations of participants at the beginning and end of the program were reviewed, along with records documenting the career progression of participants, audio recordings of interviews conducted with students, and notes of vocation-oriented counseling sessions held during each year's program. RESULTS At the conclusion of the program, 143 of 174 (82%) participants indicated they were more likely than not to undertake research training after completing their veterinary degree, compared with 106 of 174 (61%) at the beginning. Participation also stimulated interest in residency training and industry, but did little to promote interest in careers in government or the military. The percentage of participants who indicated they were more likely than not to pursue additional training in private practice decreased from 97 of 174 (56%) at the beginning of the program to 75 of 174 (43%) at the end. Information on career progression was available for 391 individuals, of whom 177 (45%) were pursuing careers of the kind envisioned by the program. However, 189 (48%) participants had a career in general or specialty clinical practice. CONCLUSIONS AND CLINICAL RELEVANCE The Leadership Program appeared to have a short-term influence on careers anticipated by program participants. However, a substantial proportion pursued careers in clinical practice after graduation.

  9. Reconstructing fungal natural product biosynthetic pathways.

    Science.gov (United States)

    Lazarus, C M; Williams, K; Bailey, A M

    2014-10-01

    Large scale fungal genome sequencing has revealed a multitude of potential natural product biosynthetic pathways that remain uncharted. Here we describe some of the methods that have been used to explore them via heterologous gene expression. We focus on filamentous fungal hosts and discuss the technological challenges and successes behind the reconstruction of fungal natural product pathways. Optimised, efficient heterologous expression of reconstructed biosynthetic pathways promises progress in the discovery of novel compounds that could be utilised by the pharmaceutical and agrochemical industries.

  10. Hedgehog -Gli 信号通路在肺癌中的研究进展%Research progress of Hedgehog-Gli signaling pathway in lung cancer

    Institute of Scientific and Technical Information of China (English)

    王磊(综述); 陈公琰(审校)

    2015-01-01

    Hedgehog-Gli signaling pathway involves in vertebrate embryonic development ,tissue differ-entiation,organogenesis,and plays an important role in homeostasis ,the maintenance of stem cell function ,regula-tion of epithelial mesenchymal transition .Hedgehog-Gli signaling pathway activation correlates with a variety of tumor development ,invasion,apoptosis and drug resistance .This review seeks to clarify the composition of Hedge-hog-Gli signaling pathway ,mechanism of action ,the role of Hedgehog-Gli signaling pathway in lung cancer de-velopment and function of lung cell of the EGFR -TKI resistance .%Hedgehog-Gli信号通路参与脊椎动物的胚胎发育、组织分化、器官形成,并且在稳定机体内环境、维持干细胞功能、调节上皮-间质转化中起重要作用。 Hedgehog-Gli信号通路的激活与多种肿瘤的发生发展、侵袭、凋亡及耐药密切相关。本文旨在阐明Hedgehog-Gli信号通路的组成,作用机制,在肺癌发生发展过程中的作用以及在EGFR-TKI治疗EGFR突变NSCLC耐药后的作用。

  11. Progress on Notch signaling pathway in the B-cell malignancies%Notch信号通路在B细胞恶性肿瘤中的研究进展

    Institute of Scientific and Technical Information of China (English)

    李艳莹

    2012-01-01

    Notch信号通路是一个进化高度保守的经典信号通路,通过调节细胞的增殖、分化和凋亡而影响细胞的命运.研究表明Notch信号的异常与多种肿瘤的发生、发展有关,其在B细胞恶性肿瘤中起双向调节作用,既表现出致瘤的作用,又能抑制肿瘤的发生,同时提示Notch信号可能成为B细胞恶性肿瘤治疗的新靶点.%The Notch signaling pathway is a highly conserved classical developmental pathway,which plays a critical role in cell-fate decision by modulating proliferation, differentiation and apoptosis. There is increasing evidence that abnormal Notch pathway is correlated with occurrence and development of many tumors. Notch signaling plays dual roles in a wide range of B-cell malignancies. It serves as either an oncogene or a tumor suppressor. Notch signaling pathway may be a novel target for B-cell malignancies therapy.

  12. Progressive posterior cortical dysfunction

    Directory of Open Access Journals (Sweden)

    Fábio Henrique de Gobbi Porto

    Full Text Available Abstract Progressive posterior cortical dysfunction (PPCD is an insidious syndrome characterized by prominent disorders of higher visual processing. It affects both dorsal (occipito-parietal and ventral (occipito-temporal pathways, disturbing visuospatial processing and visual recognition, respectively. We report a case of a 67-year-old woman presenting with progressive impairment of visual functions. Neurologic examination showed agraphia, alexia, hemispatial neglect (left side visual extinction, complete Balint's syndrome and visual agnosia. Magnetic resonance imaging showed circumscribed atrophy involving the bilateral parieto-occipital regions, slightly more predominant to the right . Our aim was to describe a case of this syndrome, to present a video showing the main abnormalities, and to discuss this unusual presentation of dementia. We believe this article can contribute by improving the recognition of PPCD.

  13. Vocational behavior analysis in psychology students

    Directory of Open Access Journals (Sweden)

    María Estrella LÓPEZ PÉREZ

    2014-06-01

    Full Text Available Introduction. The European Higher Education Area (EHEA is supporting gain relevance of vocational guidance into the frame of University Education. In order to a better planning of this guidance we need to know his contents evaluating student vocational interests of each center. The aim of the study is to analyze the indicators of Psychology students vocational behavior and his evolution and comparing those results with data of another students population. Methodology. The 329 psychology students participants from the University of Salamanca (248 in the second year and 81 in the fifth answered the questionnaire of university biodata (Rocabert, 2005. In all cases we took a significance level of ? = 0.05 carrying out samples comparison tests using U de Mann-Whitney techniques and contingency analysis. Results: The present study found significant differences between second and fifth psychology grade students and with general university population data collected by Rocabert, Descals and Gomez (2007. In general, psychology students begin their degrees with a high level interest and motivated; they are making decisions based on the academic specialty they want to work in. However, for last year students group (fith year students we detected a lower satisfaction in their studies, more difficulties in deciding what they want to do and a greater demand of information in order to choose the advisablest option for them. Conclusions. Despite the high motivation of psychology students, the nearer is his integration into the job market the higher is the need of guidance to help them to take decisions concerning specialization or the professional world.

  14. Paradoxes in Danish Vocational Education and Training

    DEFF Research Database (Denmark)

    Louw, Arnt Vestergaard; Katznelson, Noemi

    2015-01-01

    teaching practices in VET that create unmotivated, weak students and unintentional push-out effects. Further, it is suggested that the marketization of education has a profound effect on the practice in VET such that good education has come to be more associated with retaining all students in the VET......All vocational education and training schools in Denmark are required to launch retention initiatives and report yearly on their efforts to increase retention and the completion rate of their students. This article argues that the structural conditions and incentive structure around VET produces...

  15. Cursos in Educacion Vocacional (Courses in Vocational Education): A Spanish Language Introduction to the Various Areas of Vocational and Technical Education Commonly Available in the Vocational Secondary Schools of Pennsylvania.

    Science.gov (United States)

    Smith, Philip D., Jr.

    This manual presents an introduction in Spanish to the various areas of vocational and technical education commonly available in the vocational secondary schools of Pennsylvania. It discusses course requirements, future possibilities in the particular vocation, and related jobs. Included among the fields discussed are auto mechanics, electrical…

  16. Notch信号通路参与免疫炎症反应的研究进展%Research progress of notch signal pathway in immuno-inflammatory response

    Institute of Scientific and Technical Information of China (English)

    韩晗; 侯立朝

    2012-01-01

    背景 Notch信号通路是影响细胞命运的重要通路之一,在细胞分化、增殖、存活和发育中起关键作用.近年来研究表明,Notch信号还参与许多病理生理过程和多种疾病的发生、发展.目的 研究Notch信号通路在免疫炎症反应之间的作用,寻求新的免疫炎症调控靶点.内容 主要综述了Notch信号通路与免疫炎症反应的密切关系,以及对炎症性疾病的调控.趋向 Notch信号在各种炎症性疾病包括全身炎症反应综合征(systemic inflammatory response syndrome,SIRS)及脓毒症中的具体机制仍不清楚,还需更深入的研究.%Background Notch signal pathway is one of most important pathways,which plays a key role in cell fate,differentiation, proliferation, survival and development.Recent researches show that notch signal contributes to many pathophysiological process and diseases. Objective To investigate the roles of notch signal pathway in immuno -inflammatory response,and to seek new target regulating immuno-inflammation. Content This article reviews the intimate relationship between notch signal pathway and immuno-inflammatory response,as well as the regulating roles of notch signal in inflammatory diseases.Trend The concrete mechanism of notch signal in various inflammatory diseases including systemic inflammatory response syndrome (SIRS) and sepsis is still unclear,which needs further research.

  17. 转化生长因子β及其信号通路的研究进展%The Progress of Transforming Growth Factor-β and Its Signaling Pathway

    Institute of Scientific and Technical Information of China (English)

    王艳梅

    2011-01-01

    转化生长因子β(TGF-β)是具有生物活性的多肽,是TGF-β超基因家族的一员,TGF-β的功能复杂并日益受到人们的关注.TGF-β可激活Smad通路,亦可激活丝裂原活化蛋白激酶(MAPK)通路,激活的MAPK通路有细胞外信号调节蛋白激酶、p38和c-Jun N-末端激酶三条通路.现就TGF-β家族结构特征、生物学作用、TGF-β的信号转导通路作一综述.%Transforming growth factor-β( TGF-β )is a bioactive peptide, which is a member of TGF-β su-per-gene family,with complex functions,drawing more attention nowadays. It can activate the Smad pathway, and the mitogen-activated protein kinase( MAPK)pathway, including extracellular signal-regulated kinase, p38 and c-Jun N-terminal kinase. Here is to review the family structure characteristics,biological functions, and signal transduction pathways of the TGF-β.

  18. The Challenges And Risk Of Development Vocational Education In Indonesia

    Directory of Open Access Journals (Sweden)

    Yadi Mulyadi

    2009-08-01

    Full Text Available The quality of human resources (human resources really depended on good and bad points of the educational agency that prepared him. By paying attention to this link, then the urgency of the quality educational agency had finally become the key strategy in order to gains the height of the quality of human resources. Vocational education that was quality became one of the most important answers for the Indonesian nation towards the demand of the globalisation. The quality of the graduate of Vocational Education that was high, required the adoption action and the adaptation of all the requirements for the work institution/the industry, furthermore reconciled the international standard of manpower, as well as filled the current legislation regulation. Vocational education aimed at increasing intelligence, knowledge, the identity, the noble moral, as well as participants’s skills educated to live independent and followed education further in accordance with the program Vocational education (Permendiknas No. 22 Th. 2006. There were two spectra of the territory that became the aim of Vocational Education, that is preparing participants educated to the world of the work and at the same time the academic world. Therefore, then the Vocational educational curriculum became more complex both planning and his implementation. In the Vocational educational curriculum the achievement was in two spectra of the territory, that his achievement through the application of the curriculum comprehensively. This curriculum it was hoped guaranteed fully the achievement from the aim of Vocational Education. Therefore, in his fact of Vocational Education needed the operational fund that was far more bigger than that was needed by middle education the public.

  19. 泛素蛋白酶体途径在运动骨骼肌领域的研究进展%The Progress of the Research on Ubiquitin-Proteasome Pathway of Skeletal Muscle in Movement

    Institute of Scientific and Technical Information of China (English)

    朱荣

    2012-01-01

    泛素蛋白酶体途径由泛素、蛋白泛素化相关酶、26S蛋白酶体等成分组成,通过高度有序的降解过程,将细胞内错误折叠、衰老、损伤、突变的蛋白和修饰酶等分解成小分子肽,维持胞内蛋白质水平。目前发现,一次运动可引起骨骼肌途径活性升高,而重复运动可以降低途径活性,其机制尚不明确,大致可通过不依赖途径的信号通路(FOXO,p38)和依赖途径的信号通路(MyoD,NF-κB)上调可诱导的途径成分(泛素、E2/E3、蛋白酶体亚基),激活途径,引起蛋白质降解,但还需要更进一步去证实。%Components of ubiquitin-proteasome pathway(UPP) include ubiquitin,protein ubiquitination enzymes and 26S proteasome.The misfolding,aging,damage,mutation protein,and modification enzymes broke into small peptides through its highly ordered process,which maintain the intracellular protein level.The Activity of UPP could be increased in skeletal muscle after once exercise,but could be decreased after repetitive exercises.The mechanism is not clear.It could act via pathway independent signals(FOXO,p38) and pathway dependent signals(MyoD,NF-κB) to upregulate inducible pathway elements(ubiquitin,E2/E3 proteins and proteasome subunits),to active pathway,which cause protein degradation.But the detailed regulatory mechanism requires further study.

  20. Designing pathways

    DEFF Research Database (Denmark)

    Scheuer, John Damm

    2010-01-01

    The theoretical background in this chapter is organizational studies and especially theories about design and design processes in organizations. The concept of design is defined as a particular kind of work aimed at making arrangements in order to change existing situations into desired ones....... The illustrative case example is the introduction of clinical pathways in a psychiatric department. The contribution to a general core of design research is the development of the concept of design work and a critical discussion of the role of technological rules in design work....

  1. Designing pathways

    DEFF Research Database (Denmark)

    2010-01-01

    The theoretical background in this chapter is organizational studies and especially theories about design and design processes in organizations. The concept of design is defined as a particular kind of work aimed at making arrangements in order to change existing situations into desired ones....... The illustrative case example is the introduction of clinical pathways in a psychiatric department. The contribution to a general core of design research is the development of the concept of design work and a critical discussion of the role of technological rules in design work....

  2. The Advantages and Disadvantages of Assessment in Higher Vocational Education

    Institute of Scientific and Technical Information of China (English)

    LIU Ya-tao

    2013-01-01

    Assessment is always considered to be an important component in the field of higher vocational education. It serves the purpose of evaluating students’achievement and supporting learning and teaching. Assessment plays a key role by relating the in-structional activities to increase students’capabilities. The purpose aims to consider the notion of assessment as a prerequisite and will attempt to explore certain strengths and weaknesses of assessment associated with higher vocational education. Some different types and techniques of assessment in higher vocational education alongside their advantages and disadvantages will also be ex-plored.

  3. Methodology for vocational psychodiagnostics of senior schoolchildren using information technologies

    Science.gov (United States)

    Bogdanovskaya, I. M.; Kosheleva, A. N.; Kiselev, P. B.; Davydova, Yu. A.

    2017-01-01

    The article identifies the role and main problems of vocational psychodiagnostics in modern socio-cultural conditions. It analyzes the potentials of information technologies in vocational psychodiagnostics of senior schoolchildren. The article describes the theoretical and methodological grounds, content and diagnostic potentials of the computerized method in vocational psychodiagnostics. The computerized method includes three blocks of sub-tests to identify intellectual potential, personal qualities, professional interests and values, career orientations, as well as subtests to analyze the specific life experience of senior schoolchildren. The results of diagnostics allow developing an integrated psychodiagnostic conclusion with recommendations. The article contains options of software architecture for the given method.

  4. Teaching vocation versus teaching profession in educational organisations

    Directory of Open Access Journals (Sweden)

    Faustino Larrosa Martínez

    2010-12-01

    Full Text Available This paper on training prospective teachers investigates the meaning of teaching vocation and teaching profession within educational organisations, in the context of the knowledge society and in the midst of European convergence. The elements that have influenced and still influence teachers’ professional situations are analysed: tradition, social transformation, advances in research and teachers’ current needs. Then how teaching has evolved as a vocation is studied and the nature and characteristics of teaching as a profession are examined. We conclude that teaching is a vocational profession in an environment of ethical and moral pluralism.

  5. The Relative Influence of the Vocational Card Sort, the Self-Directed Search, and the Vocational Exploration and Insight Kit on High School Girls.

    Science.gov (United States)

    Takai, Ricky; Holland, John L.

    A new treatment, the Vocational Exploration and Insight Kit (VEIK), was developed to increase the number and variety of vocational options a person considers, to increase the variety of information-seeking activity, and to increase the satisfaction a person has with his or her current vocational aspiration. The VEIK is a 15-step self-administered…

  6. Pathway collages: personalized multi-pathway diagrams.

    Science.gov (United States)

    Paley, Suzanne; O'Maille, Paul E; Weaver, Daniel; Karp, Peter D

    2016-12-13

    Metabolic pathway diagrams are a classical way of visualizing a linked cascade of biochemical reactions. However, to understand some biochemical situations, viewing a single pathway is insufficient, whereas viewing the entire metabolic network results in information overload. How do we enable scientists to rapidly construct personalized multi-pathway diagrams that depict a desired collection of interacting pathways that emphasize particular pathway interactions? We define software for constructing personalized multi-pathway diagrams called pathway-collages using a combination of manual and automatic layouts. The user specifies a set of pathways of interest for the collage from a Pathway/Genome Database. Layouts for the individual pathways are generated by the Pathway Tools software, and are sent to a Javascript Pathway Collage application implemented using Cytoscape.js. That application allows the user to re-position pathways; define connections between pathways; change visual style parameters; and paint metabolomics, gene expression, and reaction flux data onto the collage to obtain a desired multi-pathway diagram. We demonstrate the use of pathway collages in two application areas: a metabolomics study of pathogen drug response, and an Escherichia coli metabolic model. Pathway collages enable facile construction of personalized multi-pathway diagrams.

  7. Vocational Dual Education System: comparison between the German model and the new Spanish vocational training

    Directory of Open Access Journals (Sweden)

    Laura Rego Agraso

    2015-06-01

    Full Text Available The German dual system of vocational training has been object of transfer in some countries all over the world, among them Spain. Indeed, in this article we try to clarify the key elements in the adapting process of this Dual System to our country, analyzing its chances of success. To do this, we contribute a descriptive study of the main elements of the German Dual System. Then, the focus will be in the changes in our country, from the LOMCE project to the legislation governing apprenticeship and training. As a kind of discussion, we pretend to clarify how cultural and organizational elements of the production system have a strongly influence in the chances of success on the Vocational Training reform policy initiatives. Finally, we completed a series of proposals for action that would contribute to the employment and an increase in the qualification among Spanish young people.

  8. Research progress of choline and dopamine signaling pathways related to myopia%近视相关胆碱与多巴胺信号通路研究进展

    Institute of Scientific and Technical Information of China (English)

    沙芳; 吴建峰

    2014-01-01

    It was confirmed that acetylcholine signaling pathway and dopamine signaling pathway play critical roles in refractive development.Many evidences have supported that acetylcholine and its receptor antagonists were closely related to the formation of experimental myopia.Retinal dopamine signaling could exert a significant influence on refractive development,and its upregulation induced by light comprises an important component of the retinal clock network;meanwhile,the retinal dopamine signaling could also participate in the regulation of retinal circadian rhythms.The role of intrinsic retinal circadian rhythms in the developing process of myopia is gaining increasing attention.Moreover,it was also found that both acetylcholine and dopamine signaling pathways influence the development of myopia.Therefore,the present paper summarizes the two signaling pathways in the mechanisms of regulating myopia process,which provides an insight into the pathogenesis of myopia and clinical ideas for the effective prevention and treatment of myopia.%大量研究证实,乙酰胆碱受体信号通路以及多巴胺信号通路在人眼屈光系统的发育中发挥关键作用.乙酰胆碱及其受体拮抗剂与实验性近视的形成密切相关.多巴胺不仅在近视发生和发展过程中起重要作用,其受光刺激上调的特性也是视网膜时钟网络的重要组成部分,参与了视网膜昼夜生理节律的调控,视网膜内在生理节律在近视发展过程中的作用已逐渐引起研究者的重视.另有研究发现,乙酰胆碱与多巴胺信号通路还可以共同影响近视的发展.就乙酰胆碱受体信号通路以及多巴胺信号通路在近视形成过程中的作用进行综述,以更深入地了解近视的发病机制,并为将来有效预防和治疗近视提供思路.

  9. Research progress in notch signaling pathway in breast cancer stem cells%Notch信号通路在乳腺癌干细胞中的研究进展

    Institute of Scientific and Technical Information of China (English)

    郭瑢; 张瑾

    2014-01-01

    Breast cancer stem cells (BCSC) are group of cells exhibiting self-renewal and multi-directional differentiation potentials. These cells have an important role in the occurrence, development, metastasis, and recurrence of breast cancer. In normal circumstances, the ability of mammary stem cells to differentiate and undergo self-renewal is governed by related signaling pathways. After this mechanism is destroyed, breast stem cells undergo abnormal differentiation, forming breast cancer stem cells that unlimitedly proliferate to develop into breast cancer. As research on BCSC increasingly deepens, regulation of BCSC by notch signaling and its crosstalk with several signaling pathways have drawn a great deal of attention in this field. This paper reports the signaling pathways of breast cancer stem cells and latest studies on this field to better understand the essential role of notch signaling pathway in the occurrence and development of breast cancer and corresponding clinical targeted therapy.%乳腺癌干细胞是一群具有自我更新及多向分化潜能的细胞,在乳腺癌的发生、发展以及转移、复发中起着极其重要的作用。正常情况下,乳腺干细胞的分化、更新能力受相关信号转导通路的严格调控,当这些信号通路发生异常干细胞将会异常分化,形成乳腺癌干细胞,并无限增殖形成肿瘤。随着人们对乳腺癌干细胞的深入研究,Notch信号通路与其他信号通路的相互作用对乳腺癌干细胞的调控逐渐被人们所重视。本文为进一步了解Notch信号通路在乳腺癌的发生、发展以及靶向治疗中的重要意义,结合乳腺癌干细胞信号通路的最新研究进展进行综述。

  10. Factors of progress in reading literacy test

    Directory of Open Access Journals (Sweden)

    Jovanović Vitomir

    2011-01-01

    Full Text Available The main goal of this study was to identify the factors which are most associated with the progress in reading literacy assessed in the PISA survey. In the preliminary sample, students from ten schools (N=235 were retested two years after the 2009 PISA original study. There were measured intrinsic and extrinsic motivation, school self-efficacy, epistemological beliefs, metacognitive strategies, socio-economic status, enjoyment and preference for reading and motivation and self-regulation. The examined factors explain 27% of the variance in reading literacy progress. Factors that contribute most to this progress are school self-efficacy, proper use of metacognitive strategies and low extrinsic motivation. Socio-economic status explained a negligible amount of variance, while some effect of type of school on progress in reading literacy (η2=7% was observed. Achievement in reading literacy is correlated with school marks. Students who attend secondary schools are more likely to make progress in reading literacy than those who attend vocational schools. An attempt was made to formulate the implications for education policy based on this research.

  11. Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Accelerates the Progression of Renal Fibrosis in Lupus Nephritis by Activating SMAD and p38 MAPK in TGF-β1 Signaling Pathway

    Directory of Open Access Journals (Sweden)

    Zhiqin Liu

    2016-01-01

    Full Text Available This study aim was to explore the effects of tumor necrosis factor-like weak inducer of apoptosis (TWEAK in lupus nephritis and its potential underlying mechanisms. MRL/lpr mice were used for in vivo experiments and human proximal tubular cells (HK2 cells were used for in vitro experiments. Results showed that MRL/lpr mice treated with vehicle solution or LV-Control shRNA displayed significant proteinuria and severe renal histopathological changes. LV-TWEAK-shRNA treatment reversed these changes and decreased renal expressions of TWEAK, TGF-β1, p-p38 MAPK, p-Smad2, COL-1, and α-SMA proteins. In vitro, hTWEAK treatment upregulated the expressions of TGF-β1, p-p38 MAPK, p-SMAD2, α-SMA, and COL-1 proteins in HK2 cells and downregulated the expressions of E-cadherin protein, which were reversed by cotreatment with anti-TWEAK mAb or SB431542 treatment. These findings suggest that TWEAK may contribute to chronic renal changes and renal fibrosis by activating TGF-β1 signaling pathway, and phosphorylation of Smad2 and p38 MAPK proteins was also involved in this signaling pathway.

  12. The Peripheralisation of the Danish Vocational Education System

    DEFF Research Database (Denmark)

    Larsen, Karin Topsø

    2013-01-01

    In the past decade, the Vocational Education Training System (VET) in Denmark has undergone a downturn in which fewer and fewer students apply for and complete a vocational education. Choosing a vocational education has become synonymous with choosing the losing team. The result is a drastic drop...... in metropolitan areas and support a migration flow of young educated people from rural municipalities toward metropolitan areas....... in the supply of vocationally trained labour. This is especially problematic for labour markets in non-metropolitan areas, where a number of production- and service- firms are still located. At the same time more and more youth are choosing and completing academic education programs, which target work places...

  13. Barriers to participation in vocational orientation programmes among prisoners

    Directory of Open Access Journals (Sweden)

    Dorien Brosens

    2015-11-01

    Full Text Available This study investigates the barriers to prisoners’ participation in vocational education, as well as the predictors of different types of barriers. Survey data derived from a project in a remand prison in Belgium (N=468 provided the empirical evidence for the analyses. The results indicate that facing situational and informational barriers are most common. Based on the different kinds of barriers, various types of non-participants can be distinguished and multinomial logistic regression analyses are conducted to identify in what way participants of vocational education differ from various types of non-participants. For instance, prisoners with a poor understanding of the Dutch language and those who never/rarely receive visitors participate less in vocational education as they are more likely to be confronted with informational barriers. We conclude this article by discussing paths for future research and implications for policy and practice to anticipate the barriers for those who want to participate in vocational education.

  14. Vocational Training of Disadvantaged Youth in the Developing Countries.

    Science.gov (United States)

    Corvalan-Vasquez, Oscar

    1983-01-01

    Defines "disadvantaged youth" and reviews vocational training and employment programs designed for them. Finds that these activities tend to favor the relatively privileged rather than those with the greatest need. (SK)

  15. A cultural turn? Vocational teacher education in Denmark

    DEFF Research Database (Denmark)

    Duch, Henriette

    teachers was a specialized and non-classified course, now it is classifies as a higher education at level six in the Danish Qualification Framework. The analysis is based on qualitative interviews with representatives of for example vocational teachers and of leaders at vocational colleges – different......As part of my Ph.D.-project the field of educational policy is analysed with a focus on the decision process on a change of vocational teacher education (Bourdieu, 1996; Duch and Rasmussen, XX). The process is seen in the light of the Bologna process. Originally, the education of Danish vocational....... The third is how to guarantee the possibility to attend a course on a lower level than six in EQF. However, the consequences of skilled workers jumping over several levels in the educational hierarchy was not discussed. The analysis is based on theories of professions using Evetts terms `from with in...

  16. The Implications of Theory Z for Departments of Vocational Education.

    Science.gov (United States)

    Dillon, Linda S.

    1983-01-01

    Describes the Theory Z management approach as postulated by William G. Ouchi and presents steps to be considered by postsecondary departments of vocational education attempting to implement this approach. (NRJ)

  17. Implementation of Industrial Work Practice management at vocational high school

    Science.gov (United States)

    Widodo, Joko; Samsudi, Sunyoto

    2017-03-01

    The purpose of this study was to develop a management model of entrepreneurship-based Industrial Work Practice (Prakerin) at Vocational High School. This research was planned for three years under Research and Development design. The respondents were public and private Vocational High Schools in Semarang, Salatiga and District of Demak, Central Java, Indonesia. Data were collected through interviews, questionnaires, observation, and documentation. The data were analyzed qualitatively and quantitatively. Preliminary study shows that the implementation of Industrial Work Practice at Vocational High School, which has been carried out, was only to prepare the graduates to become an employee of the industry instead of entrepreneur. Further study is needed to develop a management model of entrepreneurship-based Industrial Work Practice at Vocational High School.

  18. Evaluation of transition in Dutch senior secondary vocational education

    NARCIS (Netherlands)

    Lazonder, A.W.; Jong, F.P.C.M. de

    1999-01-01

    Survey responses from 55 Dutch agricultural vocational schools show that administrators believe that transition, the ability of students to change between training modes or qualification levels easily, has enhanced the flexibility of the qualification system developed under recent national reforms.

  19. Context-Driven Entrepreneurial Education in Vocational Schools

    Directory of Open Access Journals (Sweden)

    Sharmila Sandirasegarane

    2016-08-01

    Full Text Available Vocational Education and Training (VET is offered throughout the world to students of various educational backgrounds and career aspirations in an effort to create a skilled workforce. The structure of VET varies greatly across different fields and countries with high-growth, low-growth, and transitional economies. However, a common critique of many vocational institutions is that they focus on skills training without addressing related business systems. Thus, students may not understand the business strategies related to their field, which stifles job readiness and entrepreneurial potential. To counter this, a more context-driven and integrated entrepreneurial approach is proposed for VET. Benefits, disadvantages, and exemplars of various types of vocational and entrepreneurial programs are evaluated to determine how their strengths might be leveraged. Such integrated entrepreneurial and vocational training would more suitably address context-specific market needs via both practical and transferrable skills, thus helping to reduce unemployment, particularly among youth in sub-Saharan Africa.

  20. Vocational Identity and Ego Identity Status in Korean Nursing Students

    Directory of Open Access Journals (Sweden)

    Hyun-Young Koo, PhD, RN

    2016-03-01

    Conclusions: These findings show that nursing students in identity achievement status have secure and clear vocational identities. Further longitudinal and qualitative studies are needed to find out if identity formation among nursing students changes with age.

  1. School-Based Vocational Programs and Labor Laws.

    Science.gov (United States)

    Martin, James E.; Husch, James V.

    1987-01-01

    The article reviews the rules and regulations of the United States Fair Labor Standards Act in relation to school-based vocational programs and emphasizes the payment of wages across different training and placement options. (Author/CB)

  2. Development and Implementation of Continuing Vocational Pedagogic Education

    Directory of Open Access Journals (Sweden)

    G. N. Zhukov

    2013-01-01

    Full Text Available The paper is devoted to organizing and ensuring the effectiveness of continuing vocational education. The author describes the general theoretical idea of a lifelong education that no longer raises any doubts and objections. The continuing education is regarded as a versatile process affecting psychological, social and professional spheres, and requiring therefore the integrative – i. e. personal, social and competence approach.Referring to the expertise of Kemerovo region, the author considers the functional aspects of continuing vocational teacher training. The main emphasis is on the advantages of the network cooperation of institutions representing different educational levels and structures. Such cooperation involves the qualitative changes of content, as well as economics and management of vocational education. The experimental project of the network lead-up for vocational training masters is described. 

  3. Students’ Preferred Characteristics of Learning Environments in Vocational Secondary Education

    Directory of Open Access Journals (Sweden)

    Ingeborg Placklé

    2014-12-01

    Full Text Available If teachers and teacher educators are willing to support the learning of students, it is important for them to learn what motivates students to engage in learning. Students have their own preferences on design characteristics of powerful learning environments in vocational education. We developed an instrument - the Inventory Powerful Learning Environments in Vocational Education - to measure students’ preferences on characteristics of powerful learning environments in vocational education. We investigated whether student preferences on the design of their learning environments are in line with what is described in the literature as beneficial for learning. Data of 544 students show that the preferences of students support most characteristics of PLEs in vocational education. Looking through the eyes of students, teachers have to challenge their students and encourage them to take their learning in their own hands. Adaptive learning support is needed. Remarkable, students do not prefer having reflective dialogues with teachers or peers.

  4. Vocational Education and the Training of Industrial Labour in Brazil.

    Science.gov (United States)

    Moura Castro, Claudio de

    1979-01-01

    Focusing on issues related to the training of industrial workers in Brazil, this article reports the findings of a study which evaluated the effectiveness of vocational training offered by the National Industrial Apprenticeship Service. (LRA)

  5. Study on the cohesion and coherence in English teaching between junior middle school and vocational school

    Institute of Scientific and Technical Information of China (English)

    范佳

    2012-01-01

      English in junior middle school is the basis of English in vocational school. As the current situation of vocational school students' English is unsatisfactory after they graduate from junior middle school and the study on the cohesion and coherence in English teaching between junior middle school and vocational school is a little. According to the current situation,this paper aims to search the ways of connecting junior middle school English teaching and vocational school English teaching. We can find the relationship between junior middle school English teaching and vocational school English teaching and the ways to help the vocational school students learn English wel .

  6. Emotional Education in English Teaching in Vocational Colleges

    Institute of Scientific and Technical Information of China (English)

    金秀金

    2008-01-01

    English teaching in vocational colleges must manifest its essence and help students feel the spirit of the language.Looking from the humanism of language,we cannot abandon the humanity attribute of the language,study environment and the humanities concern.Therefore,we must pay more attention to students'emotion,conduct a series of humanities concern throughout the whole teaching process in vocational colleges.

  7. Research progress on Slit2-Robo1 signaling pathway in lung cancer%肺癌相关的 Slit2-Robo1信号通路的研究进展

    Institute of Scientific and Technical Information of China (English)

    孙瑜(综述); 陈公琰(审校)

    2014-01-01

    Tumor growth and migration are correlated with continuous neovascularization .Slit2-Robo1 signal pathway initially positioned in the nervous system plays an important role in the growth and neuronal axon guidance during migration.However,vascular system resembles the structural features and growth mechanism of neural system .Recent researches have shown that Slit 2-Robo1 signaling pathway plays an important role in vas-cular system,especially in tumor vessel .And Slit2-Robo1 has been shown to play a role in brain metastasis in breast cancer and supporting tumor growth in melanoma .Therefore,the role of Slit2-Robo1 in tumor growth and migration depends on the cancer type .Currently ,researches in this field show controversial results .And the status of Slit2-Robo1 signaling pathway in lung cancer is reviewed in this essay .%恶性肿瘤的生长和转移离不开新生血管的形成。 Slit2-Robo1信号通路最初是在神经系统中被发现,且在轴突导向生长和神经细胞迁移过程中发挥重要作用,血管系统和神经系统的结构和功能具有相似之处,近年来研究发现Slit2-Robo1信号通路在血管系统,特别是肿瘤血管中具有重要的作用,并在不同肿瘤中发挥的作用不同,已发现Slit2-Robo1可以抑制乳腺癌脑转移的扩散,同时,Slit2-Robo1也可以促进黑素瘤中的肿瘤生长。本文对与肺癌相关的Slit2-Robo1信号通路现状做一综述。

  8. The Place of Vocational Pedagogy in Pedagogical Science System

    Directory of Open Access Journals (Sweden)

    N. V. Ronzhina

    2015-02-01

    Full Text Available  The paper is devoted to defining the place of professional pedagogy in the system of pedagogic sciences. It is justified by the goal-setting idea that implies the competent personality development in the process of vocational training and life long self-development. The need for vocational pedagogy was caused by the social demand for the unified successive system of vocational training. The pedagogic problems can be divided according to the goal setting into the two main categories: integration into the social and natural environment (socialization, and integration in professional environment (professionalism. Therefore, pedagogy incorporates two main spheres: the general and vocational pedagogy, in which the other types of pedagogic knowledge are specified. In compliance with the goal setting, the pedagogic issues of teacher training are also divided into two groups: 1 training teachers for socialization system– the goal of pedagogic training; 2 training teachers for professional system – the goal of vocational teacher training. Such division is rather formal as every educational establishment within the framework of the federal educational standards provides up-bringing, general education, personal and civil growth, etc. However, the author demonstrates the specificity of general and vocational education in accordance with the set goals. 

  9. The Place of Vocational Pedagogy in Pedagogical Science System

    Directory of Open Access Journals (Sweden)

    N. V. Ronzhina

    2012-01-01

    Full Text Available  The paper is devoted to defining the place of professional pedagogy in the system of pedagogic sciences. It is justified by the goal-setting idea that implies the competent personality development in the process of vocational training and life long self-development. The need for vocational pedagogy was caused by the social demand for the unified successive system of vocational training. The pedagogic problems can be divided according to the goal setting into the two main categories: integration into the social and natural environment (socialization, and integration in professional environment (professionalism. Therefore, pedagogy incorporates two main spheres: the general and vocational pedagogy, in which the other types of pedagogic knowledge are specified. In compliance with the goal setting, the pedagogic issues of teacher training are also divided into two groups: 1 training teachers for socialization system– the goal of pedagogic training; 2 training teachers for professional system – the goal of vocational teacher training. Such division is rather formal as every educational establishment within the framework of the federal educational standards provides up-bringing, general education, personal and civil growth, etc. However, the author demonstrates the specificity of general and vocational education in accordance with the set goals. 

  10. Vocational Literacy in Mozambique: Historical Development, Current Challenges and Contradictions

    Directory of Open Access Journals (Sweden)

    Oleg Popov

    2016-03-01

    Full Text Available The study analyses the historical development of vocational literacy in basic education and Non-Formal Vocational Education (NFVE in Mozambique, as well as current challenges and contradictions. The theoretical lens of Cultural-Historical Activity Theory (CHAT is employed in the study. Methodologically the study was executed through an analysis of oral, printed and e-resources produced by the main stakeholders and also the reflective experiences of the authors in their extensive educational work in the country. The findings reveal poorly developed vocational literacy education in schools and non-formal settings in spite of recurrent political declarations about its importance. There is a strong dependence by formal and particularly NFVE sectors on the technical and financial support provided by international organisations. Vocational literacy courses are characterized by a lack of adequate equipment and poor practice. As a consequence, theoretical or elementary forms of vocational knowledge are dominant in the courses, resulting in the dissatisfaction of both learners and educators. Vocational literacy development proved to be a complex field that faces many challenges and ischaracterised by diverse internal contradictions.

  11. MAPK/ERK和PI3K/Akt信号通道的基因变异与甲状腺癌的发生发展及诊治%Genetic Alterations in MAPK and PI3K/Akt Signaling Pathways and the Generation, Progression, Diagnosis and Therapy of Thyroid Cancer

    Institute of Scientific and Technical Information of China (English)

    刘斌

    2012-01-01

    通过将细胞外信号转导至细胞核内,丝裂原活化蛋白激酶(MAPK)和磷脂酰肌醇-3羟基激酶/蛋白激酶B(PI3K/Akt)信号通道在细胞的生长、增殖及凋亡等活动中发挥着重要的调节作用.甲状腺癌细胞MAPK/ERK和PI3K/Akt信号通道蛋白的编码基因多异常表达.基因变异致MAPK/ERK和PI3K/Akt信号通道的过度活化及相互作用,与甲状腺癌的发生及进展密切相关.本文主要就MAPK和PI3K/Akt信号通道的基因变异在甲状腺癌发生、进展及诊断中的作用作一综述.此外,本文还将探讨同步抑制MAPK和PI3K/Akt信号通道,恢复细胞的摄碘能力,介导放射性核素靶向治疗甲状腺癌的治疗潜力.%The mitogen-activated protein kinase/extracellular signal-regulated kinase ( MAPK/ERK ) and phoshoinositide-3-kinase/protein kinase B (PI3K/Akt) signaling pathways play a major role in regulating cell growth, proliferation and apoptosis, via transmission of cell signals to cell nucleus. The genes, coding the MAPK/ ERK and PI3K/Akt signaling cascade proteins, are significantly mutated in thyroid cancer. Genetic alternations contribute to aberrant activations and interaction of MAPK/ERK and PI3K/Akt signaling pathways in consequence of malignant follicular cell transformation and progression. This review focuses mainly on the role of genetic alterations in coding MAPK/ERK and PI3K/Akt signaling pathway proteins in generation, progression and diagnosis of thyroid cancer. Moreover, it additionally points out a therapeutic potential in restoring iodine avidity of thyroid cancer cells for radionuclide targeted treatment, by synergistically inhibiting activity of signaling pathways.

  12. Career Management Skills Among Vocational Students

    Science.gov (United States)

    Zakaria, Normah; Yamin, Azlin; Maarof, Rosmawati

    2017-08-01

    Career management skills are important elements that should be present in each individual, because career selection process is crucial for school leavers. The phenomenon of students who are less knowledgeable about career at the end of school is among the main reasons they choose a career that does not fit. The situation is very worrying and poses various negative implications such as work stress and frequent swapping of jobs. In fact, research has found that most vocational students have a low level of career management. Therefore, this study is aimed to identify career management skills that students possess. The research design was a survey using a quantitative approach with a number of samples, n = 480. Data was analysed using statistical software, Statistical Package for the Social Sciences (SPSS). The results show that students’ overall career management skills are moderate. To develop human capital with the right competence, career management skills are critical requirements that can fill the gaps in industry.

  13. Secondary Vocational Education in Working Environment

    Directory of Open Access Journals (Sweden)

    Gvido Melink

    2001-12-01

    Full Text Available The authors present a successful project of secondary vocational education carried out by our school for the occupation of a toolmaker and a machinist for the companies Domel, Indramat and Niko in Železniki, considering the modern methods of teaching adults and having consistently adjusted timetable of the lectures in accordance with the working hours of the candidates and the production process respectively. Lectures, training and practical work in the workshop were performed in the company and school's workshops and laboratories. In the additional chapter the authors draw attention to the problems of payment for the teachers of technical s ubjects, who enter the education process with great working experience from companies but start here as beginners since the school regulations do not define such cases.

  14. OPG/RANKL/RANK 信号通路在运动与骨免疫学中的研究进展%Research progress of OPG/RANKL/RANK signal pathway in exercise and osteoimmunology

    Institute of Scientific and Technical Information of China (English)

    元宇; 郭健民; 邹军

    2015-01-01

    自Arron在Nature上首次提出"骨免疫学"的概念以来,关于免疫系统与骨骼系统的研究逐渐成为国内外学者研究的热点. 在骨免疫学研究中,OPG/RANKL/RANK信号通路作为免疫系统参与骨代谢调节的主要通路一直备受关注. 当机体运动时,运动所产生的机械应力以及运动诱导的免疫功能变化均能通过OPG/RANKL/RANK信号通路影响骨代谢. 适宜的运动能上调OPG基因表达,抑制RANKL分泌及其基因表达,促进IL-2、IL-18、IFN等保护性免疫细胞因子的分泌,有助于骨形成,使骨代谢趋向正平衡. 而长时间大强度运动以及过度训练则上调RANKL基因表达,下调OPG基因表达,促使破骨细胞活性增强,同时又诱导IL-6、TNF、IL-17等炎症性细胞因子分泌增多,间接促进骨吸收,使骨代谢趋向负平衡. 为了更深入地了解运动、免疫以及骨代谢之间的关系,本文综述了国内外关于运动、免疫与骨代谢的报道,旨在探讨运动对骨代谢及OPG/RANKL/RANK信号通路的调节机制以及运动应激下免疫细胞因子对OPG/RANKL/RANK信号通路的影响,为运动与骨免疫学的研究及骨代谢疾病的预防提供理论基础.%Since Arron first introduced the concept of osteoimmunology in Nature, the study of the immune system and skeletal system gradually has become a hot point nationally and internationally.In osteoimmunology, OPG/RANKL/RANK as a main signaling pathway involved in immune regulation of bone metabolism has drawn much attention.During body exercise, mechanical stress and changes of immune function can affect bone metabolism through OPG/RANKL/RANK signaling pathway.Moderate exercise can increase gene expression of OPG, inhibit secretion and gene expression of RANKL, and promote secretion of protective cytokines such as IL-2, IL-18, IFN, etc., which benefits bone formation and positive balance of bone metabolism.Strenuous longtime exercise and excessive training increase gene

  15. Wnt/β-catenin信号通路主要因子与成骨细胞研究进展%The research progress of key factors in Wnt/β-catenin signaling pathway in osteoblasts

    Institute of Scientific and Technical Information of China (English)

    贾忠宝; 张柳; 田发明

    2012-01-01

    经典Wnt/β-catenin信号通路在成骨细胞的增殖、分化及骨形成过程中起关键作用.Wnt信号通路中主要因子Wnt配体、β-catenin及转录因子Runx2表达与功能的改变,将会影响成骨细胞的增殖、分化、骨基质的形成和矿化,进而导致骨量的变化.通路中不同因子在成骨细胞分化与成熟的过程中所起作用又有所不同,而且在此过程中又会受到其它因素的影响,进而增强或减弱成骨细胞分化与成熟的进程.%The classical Wnt/β-catenin signaling pathway plays an important role in the proliferation, differentiation, and bone formation in osteoblasts. The expressive and functional alteration of main factors in Wnt/β-catenin signaling pathway, Wnt ligand, β-catenin, and transcriptional factors Runx2, can influence the proliferation, differentiation, and bone matrix formation and mineralization, eventually leading to the changes of bone mass. Different factors play different roles in the process of osteoblast differentiation and maturation. This process can be influenced by other factors to increase or decrease the differentiation and maturation of the osteoblast.

  16. 乳腺癌干细胞信号转导通路的研究进展%The Research Progress of Signal Transduction Pathway in Breast Cancer Stem Cells

    Institute of Scientific and Technical Information of China (English)

    马文浩

    2011-01-01

    随着乳腺癌干细胞的发现,人们对于乳腺癌的发生、发展、转移等机制有了进一步的了解.Wnt/β-catenin、Notch、Hedgehog 3条信号通路对乳腺干细胞的自我更新与分化起着重要的作用,一旦信号通路发生异常,乳腺干细胞就会异常分化,无限增殖形成乳腺癌干细胞,进而形成乳腺癌.为了更好地了解Wnt/β-catenin、Notch、Hedgehog 3条信号通路在乳腺癌干细胞中的调控机制,以及信号通路关键分子的表达情况,现结合信号通路的研究进展予以简要综述.%With the discovery of breast cancer stem cells,we have further understood complicated mechanisms of the occurrence, development and metastasis of breast cancer. Wnt/β-catenin, Notch, and Hedgehog, the 3 signaling pathways play an important role in self-renewal and differentiation of breast stem cells. Once this mechanism is destroyed, breast stem cells can present abnormal differentiation, proliferate unlimitedly forming breast cancer stem cells,then develop into breast cancer. Here is to make a brief summary on relevant signal transduction pathway in the occurrence and development of breast cancer and key molecules of self-renewal of breast cancer stem cells.

  17. Restrictions and Countermeasures of Rural Vocational Education in Urban-rural Integration

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Developing rural vocational education is of great significance to urban-rural integration: developing rural vocational education is helpful to cultivating new farmers for construction of new socialist countryside,favorable to improving farmers’ ability of finding jobs and starting undertaking, and beneficial to transfer of rural surplus labor and acceleration of urbanization. Restrictions on development rural vocational education mainly include: low value cognition of society and social assessment of rural vocational education; out of balance of cost and expected return of rural vocational education; the quality of supply of rural vocational education failure to satisfy demand of socio-economic development; imperfect rural vocational education system. In view of these,following countermeasures and suggestions are put forward: strengthen propaganda and guidance to build environment of public opinion for rural vocational education; push forward rural vocational compulsory education system to lay social foundation for rural vocational education; reinforce policy support to assist in building rural vocational education system; improve education system to build overall framework of rural vocational education; perfect laws and regulations to establish system and norm for development of rural vocational education.

  18. Auditory pathways: anatomy and physiology.

    Science.gov (United States)

    Pickles, James O

    2015-01-01

    This chapter outlines the anatomy and physiology of the auditory pathways. After a brief analysis of the external, middle ears, and cochlea, the responses of auditory nerve fibers are described. The central nervous system is analyzed in more detail. A scheme is provided to help understand the complex and multiple auditory pathways running through the brainstem. The multiple pathways are based on the need to preserve accurate timing while extracting complex spectral patterns in the auditory input. The auditory nerve fibers branch to give two pathways, a ventral sound-localizing stream, and a dorsal mainly pattern recognition stream, which innervate the different divisions of the cochlear nucleus. The outputs of the two streams, with their two types of analysis, are progressively combined in the inferior colliculus and onwards, to produce the representation of what can be called the "auditory objects" in the external world. The progressive extraction of critical features in the auditory stimulus in the different levels of the central auditory system, from cochlear nucleus to auditory cortex, is described. In addition, the auditory centrifugal system, running from cortex in multiple stages to the organ of Corti of the cochlea, is described.

  19. 哺乳动物的味觉受体及其介导的信号途径研究进展%The Research Progress of Taste Receptors and Signaling Transduction Pathways in Mammals

    Institute of Scientific and Technical Information of China (English)

    张敏; 魏书磊; 刘振辉

    2012-01-01

    Taste is one of the important physical sense of animals.Recent compelling evidence from rodent and human studies showed that in mammals there are 6 basic taste qualities:sweet,sour,bitter,salty,umami and fat.The progress of receptors and molecular mechanism for chemosensory transduction in taste buds has been made and reviewed within the last decade.%味觉是动物重要的生理感觉之一,众多研究结果表明,哺乳动物具有酸、甜、苦、咸、鲜(umami)、脂等六种基本味觉.近年来对于这六种味觉受体及其介导的信号途径的研究取得了很大进展,本文对此进行了综述.

  20. Novel biomarkers for progression of chronic kidney disease

    Institute of Scientific and Technical Information of China (English)

    LIU Bi-cheng; L(U) Lin-li

    2010-01-01

    @@ CHARACTERISTICS OF THE PROGRESSION OF CHRONIC KIDNEY DISEASE (CKD) Although there are different initiators of CKD, it is generally recognized that the secondary pathological pathway is quite common to all CKD. CKD may inevitably progress to end stage renal disease (ESRD) due to a vicious cycle of nephron destruction by progressive glomerulosclerosis and tubulointerstitial fibrosis.