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Sample records for vls missile capsules

  1. Variable VlsE is critical for host reinfection by the Lyme disease spirochete.

    Science.gov (United States)

    Rogovskyy, Artem S; Bankhead, Troy

    2013-01-01

    Many pathogens make use of antigenic variation as a way to evade the host immune response. A key mechanism for immune evasion and persistent infection by the Lyme disease spirochete, Borrelia burgdorferi, is antigenic variation of the VlsE surface protein. Recombination results in changes in the VlsE surface protein that prevent recognition by VlsE-specific antibodies in the infected host. Despite the presence of a substantial number of additional proteins residing on the bacterial surface, VlsE is the only known antigen that exhibits ongoing variation of its surface epitopes. This suggests that B. burgdorferi may utilize a VlsE-mediated system for immune avoidance of its surface antigens. To address this, the requirement of VlsE for host reinfection by the Lyme disease pathogen was investigated. Host-adapted wild type and VlsE mutant spirochetes were used to reinfect immunocompetent mice that had naturally cleared an infection with a VlsE-deficient clone. Our results demonstrate that variable VlsE is necessary for reinfection by B. burgdorferi, and this ability is directly related to evasion of the host antibody response. Moreover, the data presented here raise the possibility that VlsE prevents recognition of B. burgdorferi surface antigens from host antibodies. Overall, our findings represent a significant advance in our knowledge of immune evasion by B. burgdorferi, and provide insight to the possible mechanisms involved in VlsE-mediated immune avoidance.

  2. Variable VlsE is critical for host reinfection by the Lyme disease spirochete.

    Directory of Open Access Journals (Sweden)

    Artem S Rogovskyy

    Full Text Available Many pathogens make use of antigenic variation as a way to evade the host immune response. A key mechanism for immune evasion and persistent infection by the Lyme disease spirochete, Borrelia burgdorferi, is antigenic variation of the VlsE surface protein. Recombination results in changes in the VlsE surface protein that prevent recognition by VlsE-specific antibodies in the infected host. Despite the presence of a substantial number of additional proteins residing on the bacterial surface, VlsE is the only known antigen that exhibits ongoing variation of its surface epitopes. This suggests that B. burgdorferi may utilize a VlsE-mediated system for immune avoidance of its surface antigens. To address this, the requirement of VlsE for host reinfection by the Lyme disease pathogen was investigated. Host-adapted wild type and VlsE mutant spirochetes were used to reinfect immunocompetent mice that had naturally cleared an infection with a VlsE-deficient clone. Our results demonstrate that variable VlsE is necessary for reinfection by B. burgdorferi, and this ability is directly related to evasion of the host antibody response. Moreover, the data presented here raise the possibility that VlsE prevents recognition of B. burgdorferi surface antigens from host antibodies. Overall, our findings represent a significant advance in our knowledge of immune evasion by B. burgdorferi, and provide insight to the possible mechanisms involved in VlsE-mediated immune avoidance.

  3. Variable VlsE Is Critical for Host Reinfection by the Lyme Disease Spirochete

    OpenAIRE

    Artem S Rogovskyy; Troy Bankhead

    2013-01-01

    Many pathogens make use of antigenic variation as a way to evade the host immune response. A key mechanism for immune evasion and persistent infection by the Lyme disease spirochete, Borrelia burgdorferi, is antigenic variation of the VlsE surface protein. Recombination results in changes in the VlsE surface protein that prevent recognition by VlsE-specific antibodies in the infected host. Despite the presence of a substantial number of additional proteins residing on the bacterial surface, V...

  4. Human antibody responses to VlsE antigenic variation protein of Borrelia burgdorferi.

    Science.gov (United States)

    Lawrenz, M B; Hardham, J M; Owens, R T; Nowakowski, J; Steere, A C; Wormser, G P; Norris, S J

    1999-12-01

    VlsE is a 35-kDa surface-exposed lipoprotein of Borrelia burgdorferi that was shown previously to undergo antigenic variation through segmental recombination of silent vls cassettes with vlsE during experimental mouse infections. Previous data had indicated that sera from North American Lyme disease patients and experimentally infected animals contained antibodies reactive with VlsE. In this study, sera from patients with Lyme disease, syphilis, and autoimmune conditions as well as from healthy controls were examined for reactivity with VlsE by Western blotting and enzyme-linked immunosorbent assay (ELISA). Strong Western blot reactivity to a recombinant VlsE cassette region protein was obtained consistently with Lyme disease sera. Although sera from Lyme disease patients also reacted with a band corresponding to VlsE in B. burgdorferi B31-5A3, interpretation was complicated by low levels of VlsE expression in in vitro-cultured B. burgdorferi and by the presence of comigrating bands. An ELISA using recombinant VlsE was compared with an ELISA using sonically disrupted B. burgdorferi as the antigen. For a total of 93 Lyme disease patient sera examined, the VlsE ELISA yielded sensitivities of 63% for culture-confirmed erythema migrans cases and 92% for later stages, as compared to 61 and 98%, respectively, for the "whole-cell" ELISA. The specificities of the two assays with healthy blood donor sera were comparable, but the VlsE ELISA was 90% specific with sera from syphilis patients, compared to 20% specificity for the whole-cell ELISA with this group. Neither assay showed reactivity with a panel of sera from 20 non-Lyme disease arthritis patients or 20 systemic lupus erythematosus patients. Our results indicate that VlsE may be useful in the immunodiagnosis of Lyme disease and may offer greater specificity than ELISAs using whole B. burgdorferi as the antigen.

  5. Missile Aerodynamics (Aerodynamique des Missiles)

    Science.gov (United States)

    1998-11-01

    guerre froide la production des missiles a baisse’, avec pour consequence une diminution des budgets de d6veloppement. Les nouveaux types de conflits ...Roma) Directeur - Gestion de l’information LUXEMBOURG (Recherche et developpement) - DRDGI 3 Voir Belgique Ministbre de la Difense nationale NORVEGE

  6. Advanced Missile Signature Center

    Data.gov (United States)

    Federal Laboratory Consortium — The Advanced Missile Signature Center (AMSC) is a national facility supporting the Missile Defense Agency (MDA) and other DoD programs and customers with analysis,...

  7. Central role of the Holliday junction helicase RuvAB in vlsE recombination and infectivity of Borrelia burgdorferi.

    Directory of Open Access Journals (Sweden)

    Tao Lin

    2009-12-01

    Full Text Available Antigenic variation plays a vital role in the pathogenesis of many infectious bacteria and protozoa including Borrelia burgdorferi, the causative agent of Lyme disease. VlsE, a 35 kDa surface-exposed lipoprotein, undergoes antigenic variation during B. burgdorferi infection of mammalian hosts, and is believed to be a critical mechanism by which the spirochetes evade immune clearance. Random, segmental recombination between the expressed vlsE gene and adjacent vls silent cassettes generates a large number of different VlsE variants within the infected host. Although the occurrence and importance of vlsE sequence variation is well established, little is known about the biological mechanism of vlsE recombination. To identify factors important in antigenic variation and vlsE recombination, we screened transposon mutants of genes known to be involved in DNA recombination and repair for their effects on infectivity and vlsE recombination. Several mutants, including those in BB0023 (ruvA, BB0022 (ruvB, BB0797 (mutS, and BB0098 (mutS-II, showed reduced infectivity in immunocompetent C3H/HeN mice. Mutants in ruvA and ruvB exhibited greatly reduced rates of vlsE recombination in C3H/HeN mice, as determined by restriction fragment polymorphism (RFLP screening and DNA sequence analysis. In severe combined immunodeficiency (C3H/scid mice, the ruvA mutant retained full infectivity; however, all recovered clones retained the 'parental' vlsE sequence, consistent with low rates of vlsE recombination. These results suggest that the reduced infectivity of ruvA and ruvB mutants is the result of ineffective vlsE recombination and underscores the important role that vlsE recombination plays in immune evasion. Based on functional studies in other organisms, the RuvAB complex of B. burgdorferi may promote branch migration of Holliday junctions during vlsE recombination. Our findings are consistent with those in the accompanying article by Dresser et al., and together

  8. Detailed analysis of sequence changes occurring during vlsE antigenic variation in the mouse model of Borrelia burgdorferi infection.

    Directory of Open Access Journals (Sweden)

    Loïc Coutte

    2009-02-01

    Full Text Available Lyme disease Borrelia can infect humans and animals for months to years, despite the presence of an active host immune response. The vls antigenic variation system, which expresses the surface-exposed lipoprotein VlsE, plays a major role in B. burgdorferi immune evasion. Gene conversion between vls silent cassettes and the vlsE expression site occurs at high frequency during mammalian infection, resulting in sequence variation in the VlsE product. In this study, we examined vlsE sequence variation in B. burgdorferi B31 during mouse infection by analyzing 1,399 clones isolated from bladder, heart, joint, ear, and skin tissues of mice infected for 4 to 365 days. The median number of codon changes increased progressively in C3H/HeN mice from 4 to 28 days post infection, and no clones retained the parental vlsE sequence at 28 days. In contrast, the decrease in the number of clones with the parental vlsE sequence and the increase in the number of sequence changes occurred more gradually in severe combined immunodeficiency (SCID mice. Clones containing a stop codon were isolated, indicating that continuous expression of full-length VlsE is not required for survival in vivo; also, these clones continued to undergo vlsE recombination. Analysis of clones with apparent single recombination events indicated that recombinations into vlsE are nonselective with regard to the silent cassette utilized, as well as the length and location of the recombination event. Sequence changes as small as one base pair were common. Fifteen percent of recovered vlsE variants contained "template-independent" sequence changes, which clustered in the variable regions of vlsE. We hypothesize that the increased frequency and complexity of vlsE sequence changes observed in clones recovered from immunocompetent mice (as compared with SCID mice is due to rapid clearance of relatively invariant clones by variable region-specific anti-VlsE antibody responses.

  9. Evaluation of the Importance of VlsE Antigenic Variation for the Enzootic Cycle of Borrelia burgdorferi.

    Directory of Open Access Journals (Sweden)

    Artem S Rogovskyy

    Full Text Available Efficient acquisition and transmission of Borrelia burgdorferi by the tick vector, and the ability to persistently infect both vector and host, are important elements for the life cycle of the Lyme disease pathogen. Previous work has provided strong evidence implicating the significance of the vls locus for B. burgdorferi persistence. However, studies involving vls mutant clones have thus far only utilized in vitro-grown or host-adapted spirochetes and laboratory strains of mice. Additionally, the effects of vls mutation on tick acquisition and transmission has not yet been tested. Thus, the importance of VlsE antigenic variation for persistent infection of the natural reservoir host, and for the B. burgdorferi enzootic life cycle in general, has not been examined to date. In the current work, Ixodes scapularis and Peromyscus maniculatus were infected with different vls mutant clones to study the importance of the vls locus for the enzootic cycle of the Lyme disease pathogen. The findings highlight the significance of the vls system for long-term infection of the natural reservoir host, and show that VlsE antigenic variability is advantageous for efficient tick acquisition of B. burgdorferi from the mammalian reservoir. The data also indicate that the adaptation state of infecting spirochetes influences B. burgdorferi avoidance from host antibodies, which may be in part due to its respective VlsE expression levels. Overall, the current findings provide the most direct evidence on the importance of VlsE for the enzootic cycle of Lyme disease spirochetes, and underscore the significance of VlsE antigenic variation for maintaining B. burgdorferi in nature.

  10. Evaluation of the Importance of VlsE Antigenic Variation for the Enzootic Cycle of Borrelia burgdorferi.

    Science.gov (United States)

    Rogovskyy, Artem S; Casselli, Timothy; Tourand, Yvonne; Jones, Cami R; Owen, Jeb P; Mason, Kathleen L; Scoles, Glen A; Bankhead, Troy

    2015-01-01

    Efficient acquisition and transmission of Borrelia burgdorferi by the tick vector, and the ability to persistently infect both vector and host, are important elements for the life cycle of the Lyme disease pathogen. Previous work has provided strong evidence implicating the significance of the vls locus for B. burgdorferi persistence. However, studies involving vls mutant clones have thus far only utilized in vitro-grown or host-adapted spirochetes and laboratory strains of mice. Additionally, the effects of vls mutation on tick acquisition and transmission has not yet been tested. Thus, the importance of VlsE antigenic variation for persistent infection of the natural reservoir host, and for the B. burgdorferi enzootic life cycle in general, has not been examined to date. In the current work, Ixodes scapularis and Peromyscus maniculatus were infected with different vls mutant clones to study the importance of the vls locus for the enzootic cycle of the Lyme disease pathogen. The findings highlight the significance of the vls system for long-term infection of the natural reservoir host, and show that VlsE antigenic variability is advantageous for efficient tick acquisition of B. burgdorferi from the mammalian reservoir. The data also indicate that the adaptation state of infecting spirochetes influences B. burgdorferi avoidance from host antibodies, which may be in part due to its respective VlsE expression levels. Overall, the current findings provide the most direct evidence on the importance of VlsE for the enzootic cycle of Lyme disease spirochetes, and underscore the significance of VlsE antigenic variation for maintaining B. burgdorferi in nature.

  11. Growth parameters and shape specific synthesis of silicon nanowires by the VLS method

    Energy Technology Data Exchange (ETDEWEB)

    Latu-Romain, Laurence; Mouchet, Celine [CEA-Grenoble, LITEN/DTNM/LCH (France); Cayron, Cyril [CEA-Grenoble, LITEN/DTH/Grenoble Electron Microscopy-Minatec (France); Rouviere, Emmanuelle; Simonato, Jean-Pierre, E-mail: jean-pierre.simonato@cea.f [CEA-Grenoble, LITEN/DTNM/LCH (France)

    2008-12-15

    In this paper the effect of varying temperature, pressure and chemical precursors on the vapour-liquid-solid (VLS) growth of silicon nanowires (Si NWs) have been investigated. Some aspects of nucleation and growth mechanisms are discussed. Control on Si NW morphology by varying the choice of gaseous precursor (silane or dichlorosilane) at elevated temperatures is reported.

  12. Capsule endoscopy

    Science.gov (United States)

    ... It is about the size of a large vitamin pill. The person swallows the capsule, and it takes pictures all the way through ... can be started in the doctor's office. The capsule is the size of a large vitamin pill, about an inch (2.5 centimeters) long ...

  13. Capsule endoscopy

    DEFF Research Database (Denmark)

    Skovsen, Anders Peter; Burcharth, Jakob; Burgdorf, Stefan Kobbelgaard

    2013-01-01

    with ultrasound, MRI, and subsequently a capsule endoscopy. Six months later, the patient presented, and an abdominal CT-scan showed mechanical small bowel obstruction with suspicion of metallic foreign body and perforation. Laparotomy showed perforation, stenosis, and foreign body, approximately 5 cm from...... the ileocecal valve. A right hemicolectomy and distal ileectomy (60 cm) with an ileostomy were performed. On further inspection of resection, a capsule endoscope was found impacted in a stenosis. The ileostomy was later reversed without complications. Conclusion. It is important to be aware of the possibility...... of capsule retention, especially in patients with known or suspected Crohn's disease, due to the propensity of Crohn's disease to form stenosis of the bowel. In cases where a stenosis is suspected, it is warranted to perform a patency capsule swallow before subjecting the patient to a capsule endoscopy....

  14. Capsule Endoscopy

    Science.gov (United States)

    ... because experience with it is limited and traditional upper endoscopy is widely available. Your doctor might recommend a capsule endoscopy procedure to: Find the cause of gastrointestinal bleeding. If you have unexplained bleeding in your digestive ...

  15. Letters: Subs, Not Missiles

    National Research Council Canada - National Science Library

    Tsipis, Kosta

    1989-01-01

      In a letter, MIT physicist Kosta Tsipis responds to a column in the August 1988 "Bulletin of the Atomic Scientists" and clarifies his position in regard to the MX and Trident II missile programs...

  16. Voc Degradation in TF-VLS Grown InP Solar Cells

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Yubo; Sun, Xingshu; Johnston, Steve; Sutter-Fella, Carolin M.; Hettick, Mark; Javey, Ali; Bermel, Peter

    2016-11-21

    Here we consider two hypotheses to explain the open-circuit voltage (VOC) degradation observed in thin-film vapor-liquid-solid (TF-VLS) grown p-type InP photovoltaic cells: bandgap narrowing and local shunting. First, a bandgap (Eg) narrowing effect is hypothesized, based on the surface inhomogeneity of VLS InP captured by the photoluminescence (PL) image. The PL data was used to estimate a spatially-resolved active VOC across surface of the InP sample. Combining this data with the effective Jsc allowed an assessment of the I-V characteristics of individual unit cells. Next, an H-SPICE diode compact model was utilized to reproduce the I-V characteristics of the whole sample. We find a good fit to the I-V performance of TF-VLS grown InP solar cell. Second, a local shunting effect was also considered as an alternative explanation of the VOC degradation effect. Again, PL image data was used, and small local shunt resistance was added in arbitrary elementary unit cells to represent certain dark spots seen in the PL image and dictate the VOC degradation occurred in the sample.

  17. The Effectiveness of the U.S. Missile Defense Capabilities as a Deterrent to the North Korean Missile Threat

    Science.gov (United States)

    2007-12-01

    THE U.S. MISSILE DEFENSE CAPABILITIES AS A DETERRENT TO THE NORTH KOREAN MISSILE THREAT by Issac G. Gipson December 2007 Thesis Advisor...SUBJECT TERMS Missile Deterrence, Missile Defense , North Korean Missile Threat, North Korean Missile Systems, U.S. Missile Defense Capabilities, 16...19 III. CURRENT MISSILE DEFENSE ANALYSIS AGAINST NORTH KOREAN MISSILE THREAT

  18. Modeling Of Ballistic Missile Dynamics

    Directory of Open Access Journals (Sweden)

    Salih Mahmoud Attiya

    2013-05-01

    Full Text Available Aerodynamic modeling of ballistic missile in pitch plane is performed and the open-loop transfer function related to the jet deflector angle as input and pitch rate, normal acceleration as output has been derived with certain acceptable assumptions. For typical values of ballistic missile parameters such as mass, velocity, altitude, moment of inertia, thrust, moment and lift coefficient show that, the step time response and frequency response of the missile is unstable. The steady state gain, damping ratio and undraped natural frequency depend on the missile parameters. To stabilize the missile a lead compensator must be added to the forward loop.

  19. The North Korean Missile Program

    Science.gov (United States)

    Wright, David

    2001-04-01

    In recent years, the development of ballistic missiles by North Korea has been a key motivation for US efforts to stem missile proliferation and to develop defenses against intermediate and long-range missiles. In the 1980s, North Korea reverse-engineered short-range Soviet Scud missiles and began to produce and sell them. In 1993, it flight-tested a missile reported to have a range of up to 1,300 kilometers, which would allow it to target most of Japan. In 1998, it launched a multi-stage missile over Japan; it later announced that the launch had been an attempt to place a satellite in orbit. An important question is what these tests imply for its current capability and its possible future missile development. Since North Korea has sold missiles to countries in the Middle East and South Asia and is reported to be assisting Iran's missile development program, understanding its capabilities is relevant to security concerns in several parts of the world. In this talk I will discuss my analysis of the publicly available information about North Korea's missile tests, and my conclusions about possible future developments. This includes estimates of ranges and payloads of its next potential generation of missiles, and comments about their potential military utility.

  20. Investigating the potential role of non-vls genes on linear plasmid 28–1 in virulence and persistence by Borrelia burgdorferi

    OpenAIRE

    Magunda, Petronella R. Hove; Bankhead, Troy

    2016-01-01

    Background The lp28-1 plasmid is required for persistent infection by the Lyme disease spirochete, Borrelia burgdorferi. Mutational studies on this plasmid have shown that the vls locus is important for antigenic variation of the VlsE lipoprotein that leads to immune evasion and persistence. However, it is still unknown whether the vls system is the only genetic locus on this plasmid necessary for long-term infection, and thus the potential role of non-vls genes on lp28-1 in virulence and per...

  1. Missile defence : An overview

    NARCIS (Netherlands)

    Weimar, P.W.L.

    2012-01-01

    At the present day, an unparalleled number of international actors, be it national governments or non-state groups, have acquired or are seeking to acquire both weapons of mass destruction and the means to deliver them. Those means of delivery can be Ballistic Missiles that can bridge vast – even

  2. Missile defence : An overview

    NARCIS (Netherlands)

    Weimar, P.W.L.

    2012-01-01

    At the present day, an unparalleled number of international actors, be it national governments or non-state groups, have acquired or are seeking to acquire both weapons of mass destruction and the means to deliver them. Those means of delivery can be Ballistic Missiles that can bridge vast – even in

  3. Assessing individual radial junction solar cells over millions on VLS-grown silicon nanowires.

    Science.gov (United States)

    Yu, Linwei; Rigutti, Lorenzo; Tchernycheva, Maria; Misra, Soumyadeep; Foldyna, Martin; Picardi, Gennaro; Roca i Cabarrocas, Pere

    2013-07-12

    Silicon nanowires (SiNWs) grown on low-cost substrates provide an ideal framework for the monolithic fabrication of radial junction photovoltaics. However, the quality of junction formation over a random matrix of SiNWs, fabricated via a vapor-liquid-solid (VLS) mechanism, has never been assessed in a realistic context. To address this, we probe the current response of individual radial junction solar cells under electron-beam and optical-beam excitations. Excellent current generation from the radial junction units, compared to their planar counterparts, has been recorded, indicating a high junction quality and effective doping in the ultra-thin SiNWs with diameters thinner than 20 nm. Interestingly, we found that the formation of radial junctions by plasma deposition can be quite robust against geometrical disorder and even the crossings of neighboring cell units. These results provide a strong support to the feasibility of building high-quality radial junction solar cells over high-throughput VLS-grown SiNWs on low-cost substrates.

  4. Capsule endoscopy

    Institute of Scientific and Technical Information of China (English)

    Miguel Mu(n)oz-Navas

    2009-01-01

    Capsule endoscopy (CE) is a simple, safe, non-invasive, reliable technique, well accepted and tolerated by the patients, which allows complete exploration of the small intestine. The advent of CE in 2000 has dramatically changed the diagnosis and management of many diseases of the small intestine, such as obscure gastrointestinal bleeding, Crohn's disease, small bowel tumors, polyposis syndromes, etc. CE has become the gold standard for the diagnosis of most diseases of the small bowel. Lately this technique has also been used for esophageal and colonic diseases.

  5. Attacking the Cruise Missile Threat

    Science.gov (United States)

    2010-07-26

    little warning before a strike. Cruise missiles such as Silkworm and Exocet are designed to fly at “sea-skimming” levels only a few feet above the surface...the SS-N-2 Styx missile, a surface-to-surface antiship cruise missile. Most variants of modern cruise missiles are conversions of the Styx—the Silkworm ...number of Soviet built SS-N-2 Styxes that had been dismounted from boats.23 The Silkworm , the predominant of these variants, is the “Scud” of cruise

  6. Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity

    Directory of Open Access Journals (Sweden)

    Wilske Bettina

    2006-08-01

    Full Text Available Abstract Background At least three species of Borrelia burgdorferi sensu lato (Bbsl cause tick-borne Lyme disease. Previous work including the genome analysis of B. burgdorferi B31 and B. garinii PBi suggested a highly variable plasmid part. The frequent occurrence of duplicated sequence stretches, the observed plasmid redundancy, as well as the mainly unknown function and variability of plasmid encoded genes rendered the relationships between plasmids within and between species largely unresolvable. Results To gain further insight into Borreliae genome properties we completed the plasmid sequences of B. garinii PBi, added the genome of a further species, B. afzelii PKo, to our analysis, and compared for both species the genomes of pathogenic and apathogenic strains. The core of all Bbsl genomes consists of the chromosome and two plasmids collinear between all species. We also found additional groups of plasmids, which share large parts of their sequences. This makes it very likely that these plasmids are relatively stable and share common ancestors before the diversification of Borrelia species. The analysis of the differences between B. garinii PBi and B. afzelii PKo genomes of low and high passages revealed that the loss of infectivity is accompanied in both species by a loss of similar genetic material. Whereas B. garinii PBi suffered only from the break-off of a plasmid end, B. afzelii PKo lost more material, probably an entire plasmid. In both cases the vls gene locus encoding for variable surface proteins is affected. Conclusion The complete genome sequences of a B. garinii and a B. afzelii strain facilitate further comparative studies within the genus Borrellia. Our study shows that loss of infectivity can be traced back to only one single event in B. garinii PBi: the loss of the vls cassettes possibly due to error prone gene conversion. Similar albeit extended losses in B. afzelii PKo support the hypothesis that infectivity of Borrelia

  7. European Missile Defense and Russia

    Science.gov (United States)

    2014-07-01

    most senior level—the only one that matters in Russian decisionmaking cul - ture—is also of significance today and will also be re- ferred to later in... org /missile-defense/us-ballistic-missile-defense/p30607. 9. Email exchange with author, July 2013. 10. “Safeguard,” Washington, DC: Federation of Ameri

  8. BASICS OF COMPOUNDING: Capsules.

    Science.gov (United States)

    Allen, Loyd V

    2016-01-01

    Capsules have been used for administering medications to patients more than a century and have an important role in drug delivery. When a primary care provider prescribes a tablet, the choice is usually, but not always, limited to commercially available products. A capsule, however, can be prepared extemporaneously, which provides dosing flexibility for the primary care provider and the pharmacist. This article discusses the definitions/types of capsules, their applications, composition, preparation, capsule sizes, the encapsulation process, capsule cleaning, physiochemical considerations, quality control in the preparation of capsules, packaging/storage, stability, and patient counseling to determine the proper capsule size. Also, provided are sample formulations.

  9. Investigation of the genes involved in antigenic switching at the vlsE locus in Borrelia burgdorferi: an essential role for the RuvAB branch migrase.

    Directory of Open Access Journals (Sweden)

    Ashley R Dresser

    2009-12-01

    Full Text Available Persistent infection by pathogenic organisms requires effective strategies for the defense of these organisms against the host immune response. A common strategy employed by many pathogens to escape immune recognition and clearance is to continually vary surface epitopes through recombinational shuffling of genetic information. Borrelia burgdorferi, a causative agent of Lyme borreliosis, encodes a surface-bound lipoprotein, VlsE. This protein is encoded by the vlsE locus carried at the right end of the linear plasmid lp28-1. Adjacent to the expression locus are 15 silent cassettes carrying information that is moved into the vlsE locus through segmental gene conversion events. The protein players and molecular mechanism of recombinational switching at vlsE have not been characterized. In this study, we analyzed the effect of the independent disruption of 17 genes that encode factors involved in DNA recombination, repair or replication on recombinational switching at the vlsE locus during murine infection. In Neisseria gonorrhoeae, 10 such genes have been implicated in recombinational switching at the pilE locus. Eight of these genes, including recA, are either absent from B. burgdorferi, or do not show an obvious requirement for switching at vlsE. The only genes that are required in both organisms are ruvA and ruvB, which encode subunits of a Holliday junction branch migrase. Disruption of these genes results in a dramatic decrease in vlsE recombination with a phenotype similar to that observed for lp28-1 or vls-minus spirochetes: productive infection at week 1 with clearance by day 21. In SCID mice, the persistence defect observed with ruvA and ruvB mutants was fully rescued as previously observed for vlsE-deficient B. burgdorferi. We report the requirement of the RuvAB branch migrase in recombinational switching at vlsE, the first essential factor to be identified in this process. These findings are supported by the independent work of Lin et

  10. Adaptive Missile Guidance Using GPS

    Directory of Open Access Journals (Sweden)

    Pallavi Sharad Rupnar

    2013-05-01

    Full Text Available The name adaptive means we can guide any missile using GPS in any critical conditions. GPS guided missiles, using the exceptional navigational and surveying abilities of GPS, after being launched, could deliver a warhead to any part of the globe via the interface of the onboard computer in the missile with the GPS satellite system.GPS allows accurate targeting of various military weapons including ICBMs, cruise missiles and precision-guided munitions. Artillery projectiles with embedded GPS receivers able to withstand accelerations of 12,000 G have been developed for use in 155mm.GPS guided weapons, with their technological advances over previous, are the superior weapon of choice in modern days

  11. Ballistic Missile Defense System (BMDS)

    Science.gov (United States)

    2015-12-01

    Estimate RDT&E - Research , Development, Test, and Evaluation SAR - Selected Acquisition Report SCP - Service Cost Position TBD - To Be Determined TY - Then...all ranges and in all phases of flight. Following guidance from the President, the Secretary of Defense approved the Ballistic Missile Defense (BMD...based Midcourse Defense (GMD) system to enhance our capability against Intercontinental Ballistic Missiles. We are currently sustaining 30

  12. The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogens.

    Science.gov (United States)

    Bankhead, Troy; Chaconas, George

    2007-09-01

    The linear plasmid, lp28-1, is required for persistent infection by the Lyme disease spirochete, Borrelia burgdorferi. This plasmid contains the vls antigenic variation locus, which has long been thought to be important for immune evasion. However, the role of the vls locus as a virulence factor during mammalian infection has not been clearly defined. We report the successful removal of the vls locus through telomere resolvase-mediated targeted deletion, and demonstrate the absolute requirement of this lp28-1 component for persistence in the mouse host. Moreover, successful infection of C3H/HeN mice with an lp28-1 plasmid in which the left portion was deleted excludes participation of other lp28-1 non-vls genes in spirochete virulence, persistence and the process of recombinational switching at vlsE. Data are also presented that cast doubt on an immune evasion mechanism whereby VlsE directly masks other surface antigens similar to what has been observed for several other pathogens that undergo recombinational antigenic variation.

  13. RECONSTRUCTION OF 3D VECTOR MODELS OF BUILDINGS BY COMBINATION OF ALS, TLS AND VLS DATA

    Directory of Open Access Journals (Sweden)

    H. Boulaassal

    2012-09-01

    Full Text Available Airborne Laser Scanning (ALS, Terrestrial Laser Scanning (TLS and Vehicle based Laser Scanning (VLS are widely used as data acquisition methods for 3D building modelling. ALS data is often used to generate, among others, roof models. TLS data has proven its effectiveness in the geometric reconstruction of building façades. Although the operating algorithms used in the processing chain of these two kinds of data are quite similar, their combination should be more investigated. This study explores the possibility of combining ALS and TLS data for simultaneously producing 3D building models from bird point of view and pedestrian point of view. The geometric accuracy of roofs and façades models is different due to the acquisition techniques. In order to take these differences into account, the surfaces composing roofs and façades are extracted with the same algorithm of segmentation. Nevertheless the segmentation algorithm must be adapted to the properties of the different point clouds. It is based on the RANSAC algorithm, but has been applied in a sequential way in order to extract all potential planar clusters from airborne and terrestrial datasets. Surfaces are fitted to planar clusters, allowing edge detection and reconstruction of vector polygons. Models resulting from TLS data are obviously more accurate than those generated from ALS data. Therefore, the geometry of the roofs is corrected and adapted according to the geometry of the corresponding façades. Finally, the effects of the differences between raw ALS and TLS data on the results of the modeling process are analyzed. It is shown that such combination could be used to produce reliable 3D building models.

  14. Elaboration and characterization of boron doping during SiC growth by VLS mechanism

    Science.gov (United States)

    Soueidan, Maher; Ferro, Gabriel; Nsouli, Bilal; Roumié, Mohamad; Habka, Nada; Souliere, Véronique; Bluet, Jean-Marie; Kazan, Michel

    2011-07-01

    VLS mechanism was used for growing boron doped homoepitaxial SiC layers on 4H-SiC(0 0 0 1) 8° off substrate. Si-based melts were fed by propane in the temperature range 1450-1500 °C. Two main approaches were studied to incorporate boron during growth: (1) adding elemental B in the initial melt, with two different compositions: Si 90B 10 and Si 27Ge 68B 5; the growth was performed at 1500 °C; (2) adding B 2H 6 to the gas phase during growth with a melt composition of Si 25Ge 75; the growth was performed at 1450 °C. In most cases, the growth time was limited by liquid loss. The longest growth duration (1 h) was obtained when adding B 2H 6 to the gas phase. In the case of Si 90B 10 melt, the surface morphology exhibits large and parallel terraces whereas the step front is more undulated when adding Ge. Raman and photoluminescence characterizations performed on these layers confirmed the 4H polytype of the layers in addition to the presence of B, which results in a strong B-N donor-acceptor band. The thickness and the growth rate were determined by micro-Infrared spectroscopy. Particle Induced γ-ray Emission (PIGE) was tentatively used to detect B incorporation inside the grown layers. These results were compared to SIMS measurements from which B concentration was found to vary from 10 18 to 10 19 at cm -3.

  15. Esophageal capsule endoscopy

    Institute of Scientific and Technical Information of China (English)

    Ignacio Fernandez-Urien; Cristina Carretero; Raul Armendariz; Miguel Mu(n)oz-Navas

    2008-01-01

    Capsule endoscopy is now considered as the first imaging tool for small bowel examination.Recently,new capsule endoscopy applications have been developed,such as esophageal capsule endoscopy and colon capsule endoscopy.Esophageal capsule endoscopy in patients with suspected esophageal disorders is feasible and safe,and could be also an alternative procedure in those patients refusing upper endoscopy.Although large-scale studies are needed to confirm its utility in GERD and cirrhotic patients,current results are encouraging and open a new era in esophageal examination.

  16. Colon capsule endoscopy

    Institute of Scientific and Technical Information of China (English)

    Ignacio Fernandez-Urien; Cristina Carretero; Ana Borda; Miguel Mu(n)oz-Navas

    2008-01-01

    Wireless capsule endoscopy has become the first imaging tool for small bowel examination.Recently,new capsule endoscopy applications have been developed,such as esophageal capsule endoscopy and colon capsule endoscopy.Clinical trials results have shown that colon capsule endoscopy is feasible,accurate and safe in patients suffering from colonic diseases.It could be a good alternative in patients refusing conventional colonoscopy or when it is contraindicated.Upcoming studies are needed to demonstrate its utilty for colon cancer screening and other indications such us ulcerative colitis.Comparative studies including both conventional and virtual colonoscopy are also required.

  17. Hyper Velocity Missiles For Defence

    Directory of Open Access Journals (Sweden)

    Faqir Minhas

    2005-10-01

    Full Text Available The paper reviews the history of technical development in the field of hypervelocity missiles. It highlights the fact that the development of anti-ballistic systems in USA, Russia, France, UK, Sweden, and Israel is moving toward the final deployment stage; that USA and Israel are trying to sell PAC 2 and Arrow 2 to India; and that India’s Agni and Prithvi missiles have improved their accuracy, with assistance from Russia. Consequently, the paper proposes enhanced effort for development in Pakistan of a basic hypersonic tactical missile, with 300 KM range, 500 KG payload, and multi-rolecapability. The author argues that a system, developed within the country, at the existing or upgraded facilities, will not violate MTCR restrictions, and would greatly enhance the country’s defense capability. Furthermore, it would provide high technology jobs toPakistani citizens. The paper reinforces the idea by suggesting that evolution in the field of aviation and electronics favors the development of ballistic, cruise and guided missile technologies; and that flight time of short and intermediate range missiles is so short that its interception is virtually impossible.

  18. Joint Air-to-Ground Missile (JAGM)

    Science.gov (United States)

    2015-12-01

    Navy. The JAGM mission is to develop the next generation of aviation launched fire and forget missiles to replace the HELLFIRE laser and Longbow...EMD contract to develop the next generation of aviation launched missiles to replace the HELLFIRE laser and Longbow radar missiles . JAGM December 2015...Selected Acquisition Report (SAR) RCS: DD-A&T(Q&A)823-355 Joint Air-to-Ground Missile (JAGM) As of FY 2017 President’s Budget Defense Acquisition

  19. Bayesian Missile System Reliability from Point Estimates

    Science.gov (United States)

    2014-10-28

    OCT 2014 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Bayesian Missile System Reliability from Point Estimates 5a. CONTRACT...Principle (MEP) to convert point estimates to probability distributions to be used as priors for Bayesian reliability analysis of missile data, and...illustrate this approach by applying the priors to a Bayesian reliability model of a missile system. 15. SUBJECT TERMS priors, Bayesian , missile

  20. 15 CFR 742.5 - Missile technology.

    Science.gov (United States)

    2010-01-01

    ... to the design, development, production, or use of missiles. These items are identified in ECCNs on... air vehicle systems (including cruise missile systems, target drones, and reconnaissance drones... the design, development, production, or use of missiles; (iii) The capabilities and objectives of...

  1. Impulsive control for hypervelocity missiles

    Science.gov (United States)

    Magness, R. W.

    1981-05-01

    A hypervelocity agile interceptor/quickshot is being developed for defense of ballistic missile launch sites. A guidance and control system is required to achieve the missile guidance accuracy necessary for direct target impact. Attitude control systems evaluated for the agile interceptor included aerodynamic controls, thrust vector controls and impulsive motor controls. The solid squib impulsive control motion was selected because of high response rate, low weight and low volume. A baseline motor configuration was designed and a solid propellant squib was developed for use in the control system. Ballistic pendulum and bench tests were conducted with a test impulsive control motor to measure nominal performance, establish the standard deviation of performance, and define requirements to prevent sympathetic ignition. A dynamic control wind tunnel test was also conducted to determine the impulse augmentation due to the impulsive motor jet interaction with the missile boundary layer. The degree and direction of augmentation was measured for variations in Mach number and angle of attack.

  2. Remote control missile model test

    Science.gov (United States)

    Allen, Jerry M.; Shaw, David S.; Sawyer, Wallace C.

    1989-01-01

    An extremely large, systematic, axisymmetric body/tail fin data base was gathered through tests of an innovative missile model design which is described herein. These data were originally obtained for incorporation into a missile aerodynamics code based on engineering methods (Program MISSILE3), but can also be used as diagnostic test cases for developing computational methods because of the individual-fin data included in the data base. Detailed analysis of four sample cases from these data are presented to illustrate interesting individual-fin force and moment trends. These samples quantitatively show how bow shock, fin orientation, fin deflection, and body vortices can produce strong, unusual, and computationally challenging effects on individual fin loads. Comparisons between these data and calculations from the SWINT Euler code are also presented.

  3. Embedded Systems - Missile Detection/Interception

    Directory of Open Access Journals (Sweden)

    Luis Cintron

    2010-01-01

    Full Text Available Missile defense systems are often related to major military resources aimed at shielding a specific region from incoming attacks. They are intended to detect, track, intercept, and destruct incoming enemy missiles. These systems vary in cost, efficiency, dependability, and technology. In present times, the possession of these types of systems is associated with large capacity military countries. Demonstrated here are the mathematical techniques behind missile systems which calculate trajectories of incoming missiles and potential intercept positions after initial missile detection. This procedure involved the use of vector-valued functions, systems of equations, and knowledge of projectile motion concepts.

  4. New porcine test-model reveals remarkable differences between algorithms for spectrophotometrical haemoglobin saturation measurements with VLS

    DEFF Research Database (Denmark)

    Gade, John; Greisen, Gorm

    2016-01-01

    The study created an 'ex vivo' model to test different algorithms for measurements of mucosal haemoglobin saturation with visible light spectrophotometry (VLS). The model allowed comparison between algorithms, but it also allowed comparison with co-oximetry using a 'gold standard' method. This has......  -32.8 to  +29.9 percentage points and from  -5.0 to  +9.2 percentage points, respectively. CONCLUSION: the algorithms showed remarkable in-between differences when tested on raw-spectra from an 'ex vivo' model. All algorithms had bias, more marked at high oxygenation than low oxygenation. Three...

  5. Engineering scale development of the Vapor-Liquid-Solid (VLS) process for the production of silicon carbide fibrils

    Energy Technology Data Exchange (ETDEWEB)

    Hollar, W.E. Jr. [Carborundum Co., Niagara Falls, NY (United States). Technology Div.; Mills, W.H. [BP America, Inc., Cleveland, OH (United States)

    1993-09-01

    Vapor-liquid-solid (VLS)SiC fibrils are used as reinforcement in ceramic matrix composites (CMC). A program has been completed for determining process scaleup parameters and to produce material for evaluation in a CMC. The scaleup is necessary to lower production cost and increase material availability. Scaleup parameters were evaluated in a reactor with a vertical dimension twice that of the LANL reactor. Results indicate that the scaleup will be possible. Feasibility of recycling process gas was demonstrated and the impact of postprocessing on yields determined.

  6. Trajectory Optimization Design for Morphing Wing Missile

    Institute of Scientific and Technical Information of China (English)

    Ruisheng Sun; Chao Ming; Chuanjie Sun

    2015-01-01

    This paper presents a new particle swarm optimization ( PSO) algorithm to optimize the trajectory of morphing⁃wing missile so as to achieve the enlargement of the maximum range. Equations of motion for the two⁃dimensional dynamics are derived by treating the missile as an ideal controllable mass point. An investigation of aerodynamic characteristics of morphing⁃wing missile with varying geometries is performed. After deducing the optimizing trajectory model for maximizing range, a type of discrete method is put forward for taking optimization control problem into nonlinear dynamic programming problem. The optimal trajectory is solved by using PSO algorithm and penalty function method. The simulation results suggest that morphing⁃wing missile has the larger range than the fixed⁃shape missile when launched at supersonic speed, while morphing⁃wing missile has no obvious range increment than the fixed⁃shape missile at subsonic speed.

  7. NIF capsule performance modeling

    OpenAIRE

    Weber S.; Callahan D.; Cerjan C.; Edwards M.; Haan S.; Hicks D.; Jones O.; Kyrala G.; Meezan N.; Olson R; Robey H.; Spears B.; Springer P.; Town R.

    2013-01-01

    Post-shot modeling of NIF capsule implosions was performed in order to validate our physical and numerical models. Cryogenic layered target implosions and experiments with surrogate targets produce an abundance of capsule performance data including implosion velocity, remaining ablator mass, times of peak x-ray and neutron emission, core image size, core symmetry, neutron yield, and x-ray spectra. We have attempted to match the integrated data set with capsule-only simulations by adjusting th...

  8. Robust missile feedback control strategies

    NARCIS (Netherlands)

    Trottemant, E.J.; Scherer, C.W.; Weiss, M.; Vermeulen, A.

    2010-01-01

    The nature of the missile interception problem with two noncooperative players leads to the field of differential games. Introducing nonlinear uncertain models can potentially lead to nonexistence of game theoretic equilibrium strategies, computationally intractable problems, and/or highly reduced p

  9. Acceleration effects on missile aerodynamics

    CSIR Research Space (South Africa)

    Gledhill, Irvy MA

    2010-09-01

    Full Text Available Practical requirements are now arising in which significant acceleration takes place during flight; 5th generation missiles, such as A-Darter, execute turns at 100 g, where g is the acceleration due to gravity, and thrust from propulsion systems may...

  10. Missile vascular injuries: 19-year experience.

    Science.gov (United States)

    Ahanger, Abdul Gani; Wani, Mohd Lateef; Lone, Reyaz Ahmad; Singh, Shyam; Hussain, Zahur; Mir, Ishtiyak A; Irshad, Ifat; Ashraf, Hakeem Zubair; Dar, Abdul Majeed; Lone, Ghulam Nabi; Bhat, Mohammad Akbar; Sharma, Mukand Lal

    2010-03-01

    Missile vascular injuries have reached an epidemic proportion in Kashmir valley since the eruption of militancy. The present study was undertaken to analyze the mode, pattern, presentation, and management of missile vascular injuries. A retrospective study of patients with missile vascular injury from January 1990 to October 2008 was undertaken. Five hundred eighty patients with missile vascular injury were studied. All patients with vascular injury due to causes other than missiles were excluded from the study. Most of the patients were treated by interpositional saphenous vein graft or end-to-end anastomosis. The most common complication was wound infection (22.7%) followed by graft occlusion (3.8%). The amputation rate was 3.3% and was higher in patients with a delay of >6 hours to revascularization and associated fractures. Missile vascular injury requires prompt resuscitation and revascularization. Preoperative angiography is seldom necessary. Doppler study may sometimes be needed to aid in the diagnosis.

  11. Electro-chemical batteries for guided missiles

    Directory of Open Access Journals (Sweden)

    H. S. Jaggi

    1966-05-01

    Full Text Available Electro-chemical batteries owing to their simplicity and ease of stowage form one of the sources of electrical power inside a missile. However, all batteries are not suited for this application. This article describes the special features required of a missile borne battery pack and discusses the characteristics of various types of batteries available today in the world. Conclusions have been drawn as to the most suitable types of batteries for missile applications.

  12. Countering Air and Missile Threats

    Science.gov (United States)

    2012-03-23

    carrying the CMs. (2) SLCMs and ground-launched cruise missiles ( GLCMs ) present opportunities for detection as well as challenges for surveillance...if possible, and engage them before they can navigate to their targets. (6) Training patterns or identifiable launch sequence events for GLCMs are...rarely observed or practiced in an overt environment. Consequently, the probability is small for conclusively identifying a GLCM TEL using current

  13. Soviet debate on missile defense

    Energy Technology Data Exchange (ETDEWEB)

    Parrott, B.

    1987-04-01

    Although the Strategic Defense Initiative (SDI) is meant to cope with the danger of a Soviet nuclear attack, the recent US debate over SDI has paid surprisingly little attention to Soviet views of ballistic missile defense. Despite the existence of a substantial body of pertinent scholarship, the debate has failed to take adequate account of major changes in Soviet ballistic missile defense policy since the mid-1960s. It has also neglected the links between current Soviet military policy and broader Soviet political and economic choices. The Soviets regard SDI not as a novel undertaking to reduce the risks of nuclear war but as an extension of the geopolitical competition between the superpowers. This competition has been dominated in the 1980s, in the Soviet view, by sharply increased US assertiveness and the decline of detente. Viewing SDI as a manifestation of these general trends, Soviet decision makers find the prospect of an unregulated race in ballistic missile defenses and military space technologies deeply unsettling. The deterioration of superpower relations has raised serious doubts in Moscow about the wisdom of Soviet external policy during the 1970s and has provoked sharp internal differences over policy toward the US. Already highly suspicious of the Reagan administration, the elite is united by a general conviction that SDI is an American gambit that may ultimately undercut past Soviet strategic gains and pose a grave new threat to Soviet security. 14 references.

  14. Missile Electro-Optical Countermeasures Simulation Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — This laboratory comprises several hardware-in-the-loop missile flight simulations designed specifically to evaluate the effectiveness of electro-optical air defense...

  15. Infrared Background and Missiles Signature Survey

    Directory of Open Access Journals (Sweden)

    D.V. Renuka

    2013-11-01

    Full Text Available The proliferation of the missile threats in the existing threat scenario for airborne platform is a serious point of consideration for any mission planning. Missile warning system is an electronic warfare support system which gives warning to the pilot when a missile is detected in the scenario. The airborne platform has to be installed with missile warning sensors to give a spherical coverage, so that the sensors can detect the IR intensity variation in the ground scenario. This IR intensity variation has to be further analysed to differentiate the raising missile intensity from the varying background clutter. In order to differentiate the threat from the background clutter, the system should have sufficient background data set for online comparison thereby having less false alarm rate. The efficiency and performance of any missile warning system is validated with respect to its probability of declaration against the false alarm rate. Hence, to realize an efficient functioning of missile warning system, building IR background data base and missile signature database are the primary task. This paper details the methodology to be adapted for the building of tactical missile IR signatures and background data.

  16. Infrared Background and Missiles Signature Survey

    Directory of Open Access Journals (Sweden)

    D.V. Renuka

    2013-12-01

    Full Text Available The proliferation of the missile threats in the existing threat scenario for airborne platform is a serious point of consideration for any mission planning. Missile warning system is an electronic warfare support system which gives warning to the pilot when a missile is detected in the scenario. The airborne platform has to be installed with missile warning sensors to give a spherical coverage, so that the sensors can detect the IR intensity variation in the ground scenario. This IR intensity variation has to be further analysed to differentiate the raising missile intensity from the varying background clutter. In order to differentiate the threat from the background clutter, the system should have sufficient background data set for online comparison thereby having less false alarm rate. The efficiency and performance of any missile warning system is validated with respect to its probability of declaration against the false alarm rate. Hence, to realize an efficient functioning of missile warning system, building IR background data base and missile signature database are the primary task. This paper details the methodology to be adapted for the building of tactical missile IR signatures and background data.Defence Science Journal, 2013, 63(6, pp.611-615, DOI:http://dx.doi.org/10.14429/dsj.63.5762

  17. ENVIRONMENTAL TECHNOLOGY VERIFICATION: JOINT (NSF-EPA) VERIFICATION STATEMENT AND REPORT: UV DISINFECTION FOR REUSE APPLICATIONS, ONDEO DEGREMONT, INC., AQUARAY® 40 HO VLS DISINFECTION SYSTEM

    Science.gov (United States)

    Verification testing of the Ondeo Degremont, Inc. Aquaray® 40 HO VLS Disinfection System to develop the UV delivered dose flow relationship was conducted at the Parsippany-Troy Hills wastewater treatment plant test site in Parsippany, New Jersey. Three reactor modules were m...

  18. Hollow microporous organic capsules

    National Research Council Canada - National Science Library

    Li, Buyi; Yang, Xinjia; Xia, Lingling; Majeed, Muhammad Irfan; Tan, Bien

    2013-01-01

    Fabrication of hollow microporous organic capsules (HMOCs) could be very useful because of their hollow and porous morphology, which combines the advantages of both microporous organic polymers and non-porous nanocapsules...

  19. Engineering Stable Hollow Capsules

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    @@ Scientists at the CAS Institute of Chemistry have been succeeded in fabricating stable hollow capsules by extending covalent layer-by-layer self-assembly(CSA)technique from 2-dimensional to 3-dimensional systems.

  20. Capsule contraction syndrome

    Directory of Open Access Journals (Sweden)

    Mesut COŞKUN

    2009-06-01

    Full Text Available Capsule contraction syndrome occurs after fibrous metaplasia of lens proteins that leads to capsular bag contraction. Excessive front capsular wrinkling is seen in capsule contraction syndrome and there is an imbalance between powers supplying capsular integrity. This situation leads to zonular weakness. Capsule contraction syndrome is associated with pseudoexfoliation, older age, uveitis, pars planitis and myotonic muscular dystrophy. In order to decrease the risk of capsule contraction syndrome, front capsulerhexis area should be open as 5.5-6 mm diameter and a curysoft intraocular lens should be used. In order to prevent lens epithelial proliferation and metaplasia, lens epithelial cells at inferior surface of front capsule should be aspirated carefully. If postoperative capsular contraction detected, front capsulotomy should be performed by Nd-YAG laser at postoperative 2 to 3 weeks. In patients that Nd-YAG laser is unsuccessful, capsular tension should be decreased by surgical microincisions. In present study, we evaluated etiology, prevention and management of capsule contraction syndrome in the light of actual literature knowledge.

  1. Infrared ship/decoy/missile encounter model

    Science.gov (United States)

    Morin, Josee; Reid, Francoise; Morin, Andre

    1993-08-01

    Simulations of missile-ship-countermeasures engagements are used to determine the effective ways of defending a ship against infrared-guided missile threats. This paper describes one type of simulation that models the engagement of a ship deploying IR decoys by an infrared-guided seeker-head missile. This model was developed to assess the efficiency of IR decoys in protecting ships against these missiles. The simulation, Missile Infrared Decoy And Ship (MIDAS), is composed of three major blocks, the infrared scene generation, the seeker simulation and the missile dynamics simulation. The infrared scene generation block produces a three-dimensional IR scene from the target ship and flare models and transforms it into the two-dimensional IR image viewed by the seeker. The seeker simulation block is based on a generic conical scan seeker which uses a crossed-detector array for target detection. It processes the IR image to select a target and generates a steering command. The missile dynamics block computes the changes in missile trajectory according to the seeker steering command. The computations performed by each of the three blocks are explained in detail.

  2. The Cooperative Ballistic Missile Defence Game

    NARCIS (Netherlands)

    Evers, L.; Barros, A.I.; Monsuur, H.

    2013-01-01

    The increasing proliferation of ballistic missiles and weapons of mass destruction poses new risks worldwide. For a threatened nation and given the characteristics of this threat a layered ballistic missile defence system strategy appears to be the preferred solution. However, such a strategy involv

  3. Principles of Guided Missiles and Nuclear Weapons.

    Science.gov (United States)

    Naval Personnel Program Support Activity, Washington, DC.

    Fundamentals of missile and nuclear weapons systems are presented in this book which is primarily prepared as the second text of a three-volume series for students of the Navy Reserve Officers' Training Corps and the Officer Candidate School. Following an introduction to guided missiles and nuclear physics, basic principles and theories are…

  4. The Cooperative Ballistic Missile Defence Game

    NARCIS (Netherlands)

    Evers, L.; Barros, A.I.; Monsuur, H.

    2013-01-01

    The increasing proliferation of ballistic missiles and weapons of mass destruction poses new risks worldwide. For a threatened nation and given the characteristics of this threat a layered ballistic missile defence system strategy appears to be the preferred solution. However, such a strategy

  5. Discrete Deterministic Modelling of Autonomous Missiles Salvos

    Directory of Open Access Journals (Sweden)

    Momcilo Milinovic

    2014-09-01

    Full Text Available The paper deals with mathematical models of sequent salvos battle, of autonomous flight missiles (AFM organized in the groups of combatants. Tactical integration of AFM system distance-controlled weapon is considered by performances of simultaneous approaches on targets, and continual battle models of guerilla and direct fire, are redesigned to the discrete-continual mixed model, for checking missiles sudden, and further salvos, attack effects. Superiority parameters, as well as losses and strengths of full, or the part of salvo battle, for the missiles groups as technology sub-systems combatants’, is expressed by mathematical and simulation examples. Targets engagements capacities of the missiles battle unit, is conducted through designed scenarios and mathematically derived in the research. Model orientated on answers about employment of rapid reaction defending tactics, by distance missiles attacks.Defence Science Journal, Vol. 64, No. 5, September 2014, pp.471-476, DOI:http://dx.doi.org/10.14429/dsj.64.5791

  6. NIF capsule performance modeling

    Directory of Open Access Journals (Sweden)

    Weber S.

    2013-11-01

    Full Text Available Post-shot modeling of NIF capsule implosions was performed in order to validate our physical and numerical models. Cryogenic layered target implosions and experiments with surrogate targets produce an abundance of capsule performance data including implosion velocity, remaining ablator mass, times of peak x-ray and neutron emission, core image size, core symmetry, neutron yield, and x-ray spectra. We have attempted to match the integrated data set with capsule-only simulations by adjusting the drive and other physics parameters within expected uncertainties. The simulations include interface roughness, time-dependent symmetry, and a model of mix. We were able to match many of the measured performance parameters for a selection of shots.

  7. One-step growth of Si 3 N 4 stem-branch featured nanostructures: Morphology control by VS and VLS mode

    Science.gov (United States)

    Wang, Qiushi; Gao, Wei; Shan, Lianchen; Zhang, Jian; Jin, Yunxia; Cong, Ridong; Cui, Qiliang

    2011-09-01

    We report here one-step synthesis of Si 3N 4 nanodendrites by selectively applying a vapor-solid (VS) and vapor-liquid-solid (VLS) strategy via direct current arc discharge method. The resultant nanodendrites were characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, transmission electron microscopy and X-ray powder diffraction. The spine-shaped nanodendrites were generated by a noncatalytic growth following a VS mode. The uniform secondary nanowire branches were epitaxial grown from two side surfaces of the nanowire stems. The pine-shaped nanodendrites were obtained through a catalytic growth in a VLS process. These branch nanowires were unsystematically grown from the nanocone-like stems. The photoluminescence spectra of the nanodendrites show a strong white light emission around 400-750 nm, suggesting their potential applications in light and electron emission devices.

  8. Engineering scale development of the vapor-liquid-solid (VLS) process for the production of silicon carbide fibrils. Phase 2

    Energy Technology Data Exchange (ETDEWEB)

    Ohnsorg, R.W.; Hollar, W.E. Jr.; Lau, S.K. [Carborundum Co., Niagara Falls, NY (United States). Technology Div.; Ko, F.K.; Schatz, K. [Advanced Product Development, Bristol, PA (United States)

    1995-04-01

    As reinforcements for composites, VLS SiC fibrils have attractive mechanical properties including high-strength, high modulus, and excellent creep resistance. To make use of their excellent mechanical properties in a composite, a significant volume fraction (>10%) of aligned, long fibrils (>2 mm) needs to be consolidated in the ceramic matrix. The fibrils must be processed into an assembly that will allow for composite fabrication while maintaining fibril alignment and length. With Advanced Product Development (APD) as the yam fabrication subcontractor, Carborundum investigated several approaches to achieve this goaL including traditional yam-forming processes such as carding and air-vortex spinning and nontraditional processes such as tape forming and wet casting. Carborundum additionally performed an economic analysis for producing 500 and 10,000 pounds of SiC fibrils annually using both conservative and more aggressive processing parameters. With the aggressive approach, the projected costs for SiC fibril production for 500 and 10,000 pounds per year are $1,340/pound and $340/pound, respectively.

  9. Wireless capsule endoscopy

    Institute of Scientific and Technical Information of China (English)

    A Mata; J Llach; JM Bordas

    2008-01-01

    Wireless capsule endoscopy is a new technique that allows complete exploration of the small bowel without external wires. Its role has been analyzed in many small bowel diseases such as obscure gastrointestinal bleeding, Crohn's disease and gastrointestinal polyposis syndromes with promising results. Studies on other pathologies (I.e. Small bowel tumour, celiac disease) are under evaluation to define the role of this technique.

  10. DDG-1000 Missile Integration: A Case Study

    Science.gov (United States)

    2014-03-01

    Effectiveness (Pk) ‐ Platform  Environment ‐ Interface Definition Requirements Flow Interface  Definition Legend Figure 28. DDG-1000 Requirements Flow (from...development specifications and gaps that still exist in requirements. 71 Legacy Missile Requirements Legend DDG1000 Missile...Office Consolidates Programs, Cuts Costs.” Sea Power, Navy League of the United States, Arlington VA. February 2004. Accessed July 2013. http

  11. Attacking the Theater Mobile Ballistic Missile Threat

    Science.gov (United States)

    1993-06-01

    and Record, �Theater Ballistic Missile Defense and US Contingency Operations,� 13. 43Greg Myre, Associated Press, �De Klerk Reveals South African...possession). ____. Briefing, subject: �WarBreaker.� 17 December 1992. Myre, Greg. Associated Press. �De Klerk Reveals South African Nuclear...April�3 May 1992, 1,44. Ordway, Frederick I. III and Ronald C. Wakeford. International Missile and Spacecraft Guide. New York: McGraw

  12. Ballistic Missile Defense. Past and Future

    Science.gov (United States)

    2010-04-01

    and deployed. These are the two big questions of the anti-ballistic missile ( ABM ) debate. It must be emphasized that the...is the extreme polarization of the opposing positions that have been taken. Consider this statement: “The whole ABM question touched off so intense...earlier that same year by the Washington Post and ABC News11 reported that 80 percent of the American population was in favor of building a missile

  13. Quality and Reliability of Missile System

    Directory of Open Access Journals (Sweden)

    Mr. Prahlada

    2002-01-01

    Full Text Available Missile system is a single-shot weapon system which requires very high quality and reliability. Therefore, quality and reliability have to be built into the system from designing to testing and evaluation. In this paper, the technological challenges encountered during development of operational missile system and the factors considered to build quality and reliability through the design, manufacture, assembly, testing and by sharing the knowledge with other aerospace agencies, industries and institutions, etc. have been presented.

  14. Acquisition of the Army Tactical Missile System Anti-Personnel/Anti-Materiel Block IA Program

    National Research Council Canada - National Science Library

    1998-01-01

    The Army Tactical Missile System Anti-PersonnellAnti-Materiel Block IA missile (Block IA) is a ground-launched missile system consisting of a surface-to-surface guided missile with an anti-personnel/anti-materiel warhead...

  15. Ballistic Missile Proliferation: An Emerging Threat 1992

    Science.gov (United States)

    1992-10-01

    Avibras has also been working sile is the Condor 2. since 1960 on the solid-propellant motors for the The Alacran is believed to be about 6.9 m long Sonda ...development to SLV Brazil Sonda II, Ill, IV; VLS SS-1000* - Future developments uncertain Indonesia RX-250 - Sounding rockets launched since 1976 Iraq...in the mid 1970s, resulting in the launch potential conflict. [Refs. 54, 58, 59, 60] of the Sonda IV sounding rocket in 1984. A few years later

  16. Variable centroid control scheme over hypersonic tactical missile

    Institute of Scientific and Technical Information of China (English)

    Yl; Yan(易彦); ZHOU; Fengqi(周凤岐)

    2003-01-01

    This paper presents a brand-new tactical missile control scheme--variable centroid vector control according to the international highlight in the field of missile control and the research status of hypersonic missile control in China. Four critical problems related with the new control method are included: improving phase control in the spinning missile single-channel control; establishing variable centroid controlled spinning missile attitude dynamics equations; analyzing variable centroid control strategies and analyzing the stability of the controlled missile and implementing robust control. The achievements and results obtained are valuable and helpful to the theoretical explorations and engineering applications.

  17. Variable centroid control scheme over hypersonic tactical missile

    Science.gov (United States)

    Yi, Yan; Zhou, Fengqi

    2003-12-01

    This paper presents a brand-new tactical missile control scheme—variable centroid vector control according to the international highlight in the field of missile control and the research status of hypersonic missile control in China. Four critical problems related with the new control method are included: improving phase control in the spinning missile single-channel control; establishing variable centroid controlled spinning missile attitude dynamics equations; analyzing variable centroid control strategies and analyzing the stability of the controlled missile and implementing robust control. The achievements and results obtained are valuable and helpful to the theoretical explorations and engineering applications.

  18. Influence of Missile Fusillade Engagement Mode on Operation Efficiency

    Institute of Scientific and Technical Information of China (English)

    BU Xian-jin; REN Yi-guang; SHA Ji-chang

    2008-01-01

    Shoot efficiency is one of the most important evaluation indexes of the operation efficiency of weapon system. In this paper, based on definitions of the probability and the expected number of missed attacking missiles, the expected numbers of anti-missiles and attacking missiles hit by single anti-missile, fusillade mechanism of multi-missile is analyzed systematically. The weapon operation efficiency in various engagement patterns is also studied. The results show that double missiles fusillade is the most feasible manner for increasing the weapon operation efficiency.

  19. Management of adhesive capsulitis

    Directory of Open Access Journals (Sweden)

    Stupay KL

    2015-08-01

    Full Text Available Kristen L Stupay,1 Andrew S Neviaser2 1Tulane University School of Medicine, New Orleans, LA, USA; 2George Washington University Medical Faculty Associates, Washington, DC, USA Abstract: Adhesive capsulitis of the shoulder is a condition of capsular contracture that reduces both active and passive glenohumeral motion. The cause of adhesive capsulitis is not known but it is strongly associated with endocrine abnormalities such as diabetes. Diverse terminology and the absence of definitive criteria for diagnosis make evaluating treatment modalities difficult. Many treatment methods have been reported, most with some success, but few have been proved to alter the natural course of this disease. Most afflicted patients will achieve acceptable shoulder function without surgery. Those who remain debilitated after 8–12 months are reasonable candidates for invasive treatments. Here, the various treatment methods and the data to support their use are reviewed. Keywords: frozen shoulder, stiff shoulder, periarthritis, painful shoulder 

  20. Missile captive carry monitoring using a capacitive MEMS accelerometer

    Science.gov (United States)

    Hatchell, Brian; Mauss, Fred; Santiago-Rojas, Emiliano; Amaya, Ivan; Skorpik, Jim; Silvers, Kurt; Marotta, Steve

    2010-03-01

    Military missiles are exposed to many sources of mechanical vibration that can affect system reliability, safety, and mission effectiveness. One of the most significant exposures to vibration occurs when the missile is being carried by an aviation platform, which is a condition known as captive carry. If the duration of captive carry exposure could be recorded during the missile's service life, several advantages could be realized. Missiles that have been exposed to durations outside the design envelop could be flagged or screened for maintenance or inspection; lightly exposed missiles could be selected for critical mission applications; and missile allocation to missions could be based on prior use to avoid overuse. The U. S. Army Aviation and Missile Research Development and Engineering Center (AMRDEC) has been developing health monitoring systems to assess and improve reliability of missiles during storage and field exposures. Under the direction of AMRDEC staff, engineers at the Pacific Northwest National Laboratory have developed a Captive Carry Health Monitor (CCHM) for the HELLFIRE II missile. The CCHM is an embedded usage monitoring device installed on the outer skin of the HELLFIRE II missile to record the cumulative hours the host missile has been in captive carry mode and thereby assess the overall health of the missile. This paper provides an overview of the CCHM electrical and package design, describes field testing and data analysis techniques used to identify captive carry, and discusses the potential application of missile health and usage data for real-time reliability analysis and fleet management.

  1. Capsule-train stability

    Science.gov (United States)

    Bryngelson, Spencer H.; Freund, Jonathan B.

    2016-07-01

    Elastic capsules flowing in small enough tubes, such as red blood cells in capillaries, are well known to line up into regular single-file trains. The stability of such trains in somewhat wider channels, where this organization is not observed, is studied in a two-dimensional model system that includes full coupling between the viscous flow and suspended capsules. A diverse set of linearly amplifying disturbances, both long-time asymptotic (modal) and transient (nonmodal) perturbations, is identified and analyzed. These have a range of amplification rates and their corresponding forms are wavelike, typically dominated by one of five principal perturbation classes: longitudinal and transverse translations, tilts, and symmetric and asymmetric shape distortions. Finite-amplitude transiently amplifying perturbations are shown to provide a mechanism that can bypass slower asymptotic modal linear growth and precipitate the onset of nonlinear effects. Direct numerical simulations are used to verify the linear analysis and track the subsequent transition of the regular capsule trains into an apparently chaotic flow.

  2. Missile Captive Carry Monitoring using a Capacitive MEMS Accelerometer

    Energy Technology Data Exchange (ETDEWEB)

    Hatchell, Brian K.; Mauss, Fredrick J.; Santiago-Rojas, Emiliano; Amaya, Ivan A.; Skorpik, James R.; Silvers, Kurt L.; Marotta, Steve

    2010-04-08

    Military missiles are exposed to many sources of mechanical vibration that can affect system reliability, safety, and mission effectiveness. One of the most significant exposures to vibration occurs when the missile is being carried by an aviation platform, which is a condition known as captive carry. If the duration of captive carry exposure could be recorded during the missile’s service life, several advantages could be realized. Missiles that have been exposed to durations outside the design envelop could be flagged or screened for maintenance or inspection; lightly exposed missiles could be selected for critical mission applications; and missile allocation to missions could be based on prior use to avoid overuse. The U. S. Army Aviation and Missile Research Development and Engineering Center (AMRDEC) has been developing health monitoring systems to assess and improve reliability of missiles during storage and field exposures. Under the direction of AMRDEC staff, engineers at the Pacific Northwest National Laboratory have developed a Captive Carry Health Monitor (CCHM) for the HELLFIRE II missile. The CCHM is an embedded usage monitoring device installed on the outer skin of the HELLFIRE II missile to record the cumulative hours the host missile has been in captive carry mode and thereby assess the overall health of the missile. This paper provides an overview of the CCHM electrical and package design, describes field testing and data analysis techniques used to identify captive carry, and discusses the potential application of missile health and usage data for real-time reliability analysis and fleet management.

  3. Theater Ballistic Missile Defense Policy, Missions and Programs: Current Status

    Science.gov (United States)

    2007-11-02

    destroy its target. A French-Italian program called SAMP/T (Sol-Air Moyenne Portee/ Terrestre ) is being considered for a point defense system; further...Patriot PAC-3 missile. The Multimode Missile includes semi-active track- via -missile guidance, improved propulsion and uses an aimed blast

  4. Capsule endoscopy in celiac disease

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Video capsule endoscopy is an attractive and patient- friendly tool that provides high quality images of the small bowel. Obscure gastrointestinal bleeding is the primary and most evaluated indication to capsule endoscopy; however, indications are expanding and a small number of preliminary reports have been presented concerning the role of video capsule endoscopy in the diagnosis of celiac disease. The purpose of this review is to update the current knowledge and to hypothesize on future perspectives of the use of video capsule endoscopy in patients with celiac disease.

  5. The effectiveness of the U.S. missile defense capabilities as a deterrent to the North Korean missile threat

    OpenAIRE

    Gipson, Issac G.

    2007-01-01

    Over the last five years, America has placed an ever-increasing emphasis on missile defense and currently spends nearly $10 billion annually on its development. The United States' current missile Defense system is integrated; it depends on the cooperation of defensive elements aboard ships, on land, in the air and space. The objective is to provide a layered defense with multiple opportunities to destroy an incoming missile. By investing heavily in missile defense technology, the United ...

  6. The new politics of missile proliferation

    Energy Technology Data Exchange (ETDEWEB)

    Karp, A. [Old Dominion Univ., Norfolk, VA (United States)

    1996-10-01

    The author addresses the most consequential proliferation battle of the 1990s which occurred in Washington over the interpretation of the long-term threat to the United States from ballistic missiles. In the early 1970s, the stabilization of the US-Soviet strategic relationship led to new disputes over the other side`s future intentions, seen most graphically in Western debates over the implications of the Soviet SS-18 and SS-20 missile programs. Today, in much the same way, proliferation politics has matured to the point that surprises are few and the most challenging problem is anticipating the more distant future. Washington`s ballistic missile proliferation battle was sparked by National Intelligence Estimate (NIE) 95-19, entitled {open_quotes}Emerging Threats to North America During the Next 15 Years,{close_quotes} released by the National Intelligence Council in November 1995. This document updated the evidence of regional missile programs reviewed in a similar report issued in 1993, and recapitulated the previous finding that {open_quotes}No country, other than the major declared nuclear powers, will develop or otherwise acquire a ballistic missile in the next 15 years that could threatened the contiguous 48 states or Canada.{close_quotes} The new report confirmed what several other studies of missile proliferation had already established: that besides the five nuclear-weapon states (the United States, Russia, China, France and Britain), only India, Israel and Japan are in a position to develop an ICBM during the foreseeable future, and while all have relevant capabilities, none are undertaking the steps necessary to develop an actual ICBM.

  7. Optimal Design of Capsule Transporting Pipeline carrying Spherical Capsules

    Science.gov (United States)

    Asim, Taimoor; Mishra, Rakesh; Ubbi, Kuldip

    2012-05-01

    A capsule pipeline transports material or cargo in capsules propelled by fluid flowing through a pipeline. The cargo may either be contained in capsules (such as wheat enclosed inside sealed cylindrical containers), or may itself be the capsules (such as coal compressed into the shape of a cylinder or sphere). As the concept of capsule transportation is relatively new, the capsule pipelines need to be designed optimally for commercial viability. An optimal design of such a pipeline would have minimum pressure drop due to the presence of the solid medium in the pipeline, which corresponds to minimum head loss and hence minimum pumping power required to drive the capsules and the transporting fluid. The total cost for the manufacturing and maintenance of such pipelines is yet another important variable that needs to be considered for the widespread commercial acceptance of capsule transporting pipelines. To address this, the optimisation technique presented here is based on the least-cost principle. Pressure drop relationships have been incorporated to calculate the pumping requirements for the system. The maintenance and manufacturing costs have been computed separately to analyse their effects on the optimisation process. A design example has been included to show the usage of the model presented. The results indicate that for a specific throughput, there exists an optimum diameter of the pipeline for which the total cost for the piping system is at its minimum.

  8. Current Trends in Tactical Missile Guidance

    Directory of Open Access Journals (Sweden)

    S. Vathsal

    2005-07-01

    Full Text Available The problem of tactical missile guidance is very challenging and has been treated using several basic metlfodologies in the past four decades. Major techniques can be grouped underclassical guidance laws, modern guidance laws, l'aws for manoeuvring targets, predictive guidance for endgame scenario, and guidance laws based on intelligent control methods. Each technique has some advantages and disadvantages while implementing in a practical system. Guidance law selection is dictated by nature of flight profile like boost, midcourse, terminal homing, etc, and also miss-distance and a single-shot kill probability. This paper presents a brief survey of the existing techniques and current trends in tactical missile guidance.

  9. Air and Missile Defense Radar (AMDR)

    Science.gov (United States)

    2015-12-01

    March 8, 2016 11:04:34 UNCLASSIFIED 4 CAPT Seiko Okano 1333 Isaac Hull Ave , SE Washington, DC 20376-7101 seiko.okano@navy.mil Phone: 202-781-0461 Fax: DSN...to the combat system. AMDR will be deployed on the Guided Missile Destroyer (DDG) 51 Flight III. AMDR December 2015 SAR March 8, 2016 11:04:34...Abbreviations Ao - Operational Availability CMS - Combat Management System DDG - Guided Missile Destroyer kW - Kilowatt TTL - Training Task List AMDR December

  10. EFP Warhead Missile Fuze Analysis and Simulation

    Institute of Scientific and Technical Information of China (English)

    LI Wei; FAN Ning-jun; WANG Zheng-jie

    2008-01-01

    The explosive formed penetrator(EFP)warhead missile projects the blast fragments in one direction normal to the missile longitudinal axis.Through analyzing on the two restrictions of EFP warhead explosion:trajectory restriction and attitude requirement,the concept of fuse time-delay tolerance is presented to be the measurement of the time of the EFP warhead explosion.The calculation models of fuze time-delaY tolerance under two restrictions are provided.Some crucial parameters playing important roles in calculation under attitude requirements are simulated.The simulation results show that the engagement plane angle,roll rate and warhead attack standoff influence the tolerance dramatically.

  11. Engineering scale development of the vapor-liquid-solid (VLS) process for the production of silicon carbide fibrils and linear fibril assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Tenhover, M.; Biernacki, J. [Carborundum Co., Niagara Falls, NY (United States); Schatz, K.; Ko, F. [Advanced Product Development, Inc., Bristol, PA (United States)

    1995-08-01

    In order to exploit the superior thermomechanical properties of the VLS fibril, the feasibility of scaled-up production of the SiC fibril is demonstrated in this study. Through time series study and computer simulation, the parameters affecting the growth process and properties of the fibrils were examined. To facilitate translation of the superior mechanical properties into higher level preform structures, conventional and unconventional processing methods were evaluated. As revealed by scanning electron microscopic examination and X-ray diffractometry, high level alignment of the fibrils was achieved by the wet-laid process.

  12. Serodiagnosis of Lyme disease by kinetic enzyme-linked immunosorbent assay using recombinant VlsE1 or peptide antigens of Borrelia burgdorferi compared with 2-tiered testing using whole-cell lysates.

    Science.gov (United States)

    Bacon, Rendi Murphree; Biggerstaff, Brad J; Schriefer, Martin E; Gilmore, Robert D; Philipp, Mario T; Steere, Allen C; Wormser, Gary P; Marques, Adriana R; Johnson, Barbara J B

    2003-04-15

    In a study of US patients with Lyme disease, immunoglobulin (Ig) G and IgM antibody responses to recombinant Borrelia burgdorferi antigen VlsE1 (rVlsE1), IgG responses to a synthetic peptide homologous to a conserved internal sequence of VlsE (C6), and IgM responses to a synthetic peptide comprising the C-terminal 10 amino acid residues of a B. burgdorferi outer-surface protein C (pepC10) were evaluated by kinetic enzyme-linked immunoassay. At 99% specificity, the overall sensitivities for detecting IgG antibody to rVlsE1 or C6 in samples from patients with diverse manifestations of Lyme disease were equivalent to that of 2-tiered testing. When data were considered in parallel, 2 combinations (IgG responses to either rVlsE1 or C6 in parallel with IgM responses to pepC10) maintained high specificity (98%) and were significantly more sensitive than 2-tiered analysis in detecting antibodies to B. burgdorferi in patients with acute erythema migrans. In later stages of Lyme disease, the sensitivities of the in parallel tests and 2-tiered testing were high and statistically equivalent.

  13. Magnetism in metal-organic capsules

    Energy Technology Data Exchange (ETDEWEB)

    Atwood, Jerry L.; Brechin, Euan K; Dalgarno, Scott J.; Inglis, Ross; Jones, Leigh F.; Mossine, Andrew; Paterson, Martin J.; Power, Nicholas P.; Teat, Simon J.

    2010-01-07

    Nickel and cobalt seamed metal-organic capsules have been isolated and studied using structural, magnetic and computational approaches. Antiferromagnetic exchange in the Ni capsule results from coordination environments enforced by the capsule framework.

  14. Magnetism in metal-organic capsules

    Energy Technology Data Exchange (ETDEWEB)

    Atwood, Jerry L.; Brechin, Euan K; Dalgarno, Scott J.; Inglis, Ross; Jones, Leigh F.; Mossine, Andrew; Paterson, Martin J.; Power, Nicholas P.; Teat, Simon J.

    2010-01-07

    Nickel and cobalt seamed metal-organic capsules have been isolated and studied using structural, magnetic and computational approaches. Antiferromagnetic exchange in the Ni capsule results from coordination environments enforced by the capsule framework.

  15. An analysis of Common Missile and TOW 2B using the Janus combat simulation

    OpenAIRE

    2002-01-01

    Approved for public release; distribution is unlimited. The US Army is currently developing a new close combat missile system, Common Missile, to replace the aging Tubelaunched, Optically-tracked, Wire-guided (TOW 2B) and HELLFIRE missile systems. The Common Missile will have a greater range and improved target acquisition capability over the current missile systems. The purpose of this thesis is to compare the performance of the Common Missile and the TOW 2B missile in a simulated ground ...

  16. Rationale for wind-borne missile criteria for DOE facilities

    Energy Technology Data Exchange (ETDEWEB)

    McDonald, J R; Murray, R

    1999-09-01

    High winds tend to pick up and transport various objects and debris, which are referred to as wind-borne missiles or tornado missiles, depending on the type of storm. Missiles cause damage by perforating the building envelope or by collapsing structural elements such as walls, columns or frames. The primary objectives of this study are as follows: (1) to provide a basis for wind-borne or tornado missile criteria for the design and evaluation of DOE facilities, and (2) to provide guidelines for the design and evaluation of impact-resistant missile barriers for DOE facilities The first objective is accomplished through a synthesis of information from windstorm damage documentation experience and computer simulation of missile trajectories. The second objective is accomplished by reviewing the literature, which describes various missile impact tests, and by conducting a series of impact tests at a Texas Tech University facility to fill in missing information.

  17. CRANIOCEREBRAL MISSILE INJURY A STATISTICAL REVIEW

    Directory of Open Access Journals (Sweden)

    ALI ALIMOHAMMADI

    1986-05-01

    Full Text Available A Statistical report of 912 battle casualtiesadmitted in a special unit of the neurological surgery department during 49 months of the recent war was given. Methods of their evaluation, operative categories, management poli¬cies including techniques of Missile and bullet removal, and their complications were discussed.

  18. Cruise missiles should not stop START

    Energy Technology Data Exchange (ETDEWEB)

    Tsipis, K.

    1988-11-01

    A method for verifying a cruise-missile agreement that would be acceptable to the military, industrial, and intelligence communities in both nations must be as unintrusive as possible, while remaining immune to cheating of any significance. This is the goal of the technical solutions outlined here. The elements of a verification regime described do not require routine, intrusive, on-site visits to naval vessels, aircraft, air bases, or weapons magazines where missiles may be stored. They do not interfere with the operational readiness of the missiles, and they protect legitimate military secrets of the inspected nation. If supported by competent national technical means of verification such as those both sides already employ, with a small number of on-site challenge inspections, a combination of technical solutions and procedures such as these could be effective. They would adequately safeguard the national security and sovereignty of the participating nations while providing policymakers with the option of a treaty that limits the number of long-range nuclear cruise missiles or eliminates them completely. As discussed, there are problems that remain to be addressed, but they should not be allowed to block a U.S.-Soviet agreement significantly reducing strategic nuclear arsenals.

  19. Integrated Air and Missile Defense (IAMD)

    Science.gov (United States)

    2015-12-01

    IBCS. The cruise missile surrogate, an MQM-107 Drone Target, flew a low altitude trajectory against an asset defended by an Army IAMD task force...FY 2048 The difference in the acquisition quantity of 443 and the sustainment quantity of 427 is due to 16 RDT&E prototypes that are not to be

  20. Minimum variation guidance laws for interceptor missiles

    NARCIS (Netherlands)

    Weiss, M.; Shima, T.

    2014-01-01

    This paper introduces a new approach to guidance law design using linear quadratic optimal control theory, minimizing throughout the engagement the variation of the control input as well as the integral control effort. The guidance law is derived for arbitrary order missile dynamics and target maneu

  1. Influence of capsule shell composition on the performance indicators of hypromellose capsule in comparison to hard gelatin capsules.

    Science.gov (United States)

    Al-Tabakha, Moawia M; Arida, Adi Issam; Fahelelbom, Khairi M S; Sadek, Bassem; Saeed, Dima Ahmed; Abu Jarad, Rami A; Jawadi, Jeevani

    2015-01-01

    The purpose of this study was to assess the in vitro performances of "vegetable" capsules in comparison to hard gelatin capsules in terms of shell weight variation, reaction to different humidity conditions, resistance to stress in the absence of moisture, powder leakage, disintegration and dissolution. Two types of capsules made of HPMC produced with (Capsule 2) or without (Capsule 3) a gelling agent and hard gelatin capsules (Capsule 1) were assessed. Shell weight variability was relatively low for all tested capsules shells. Although Capsule 1 had the highest moisture content under different humidity conditions, all capsule types were unable to protect the encapsulated hygroscopic polyvinylpyrrolidone (PVP) powder from surrounding humidity. The initial disintegration for all Capsule 1 occurred within 3 min, but for other types of capsules within 6 min (n = 18). Dissolution of acetaminophen was better when the deionized water (DIW) temperature increased from 32 to 42 °C in case of Capsule 1, but the effect of temperature was not significant for the other types of capsules. Acetaminphen dissolution from Capsule 1 was the fastest (i.e. >90% in 10 min) and independent of the media pH or contents unlike Capsule 2 which was influenced by the pH and dissolution medium contents. It is feasible to use hypromellose capsules shells with or without gelling agent for new lines of pharmaceutical products, however, there is a window for capsule shells manufacturing companies to improve the dissolution of their hypromellose capsules to match the conventional gelatin capsule shells and eventually replace them.

  2. Squeezing through: capsule or bubble?

    CERN Document Server

    Dawson, Geoffrey

    2013-01-01

    In this fluid dynamics video, we compare the deformation of two flexible particles as they propagate through a sudden constriction of a liquid filled channel under constant-flux flow: a gas bubble, and a capsule formed by encapsulating a liquid droplet in a cross-linked polymeric membrane. Both bubble and capsule adopt highly contorted configurations as they squeeze through the constriction, exhibit broadly similar features over a wide range of flow rates, and rupture for sufficiently high flow rates. However, at flow rates prior to rupture, certain features of the deformation allow bubble and capsule to be distinguished: bubbles exhibit a tip-streaming singularity associated with critical thinning of the rear of the bubble, while the capsule membrane wrinkles under large compressive stresses induced by the constriction.

  3. Modeling and Simulating Dynamics of Missiles with Deflectable Nose Control

    Institute of Scientific and Technical Information of China (English)

    Gao Yuan; Gu Liangxian; Pan Lei

    2009-01-01

    This article investigates the dynamic characteristics of deflectable nose missiles with rotary single-channel control. After introduction of effective attack and sideslip angles as well as quasi-body coordinates based on the spin characteristics of the missile's body, an integrated rigid kinetic model of missile with deflectable nose control is set up in the quasi-body coordinates considering the interaction between the missile's nose and body by using rootless multi-rigid-body system dynamics and is linearized. Then an analysis with simulation is conducted to investigate the coupling characteristics between the channels, the influences of nose deflection on the body and the dynamic characteristics of missile's body. The results indicate that various channels of missiles with deflectable nose control are coupled cross-linked; the nose deflection tends to make the body move in the opposite direction and, finally, evidences the correctness and reasonability of the kinetic model proposed by this article.

  4. Ballistic Missile Silo Door Monitoring Analysis

    Energy Technology Data Exchange (ETDEWEB)

    EDENBURN,MICHAEL W.; TROST,LAWRENCE C.

    2000-01-01

    This paper compares the cost and effectiveness of several potential options that may be used to monitor silo-based ballistic missiles. Silo door monitoring can be used to verify that warheads removed to deactivate or download silo-based ballistic missiles have not been replaced. A precedent for monitoring warhead replacement using reentry vehicle on site inspections (RV-OSIs) and using satellites has been established by START-I and START-II. However, other monitoring options have the potential to be less expensive and more effective. Three options are the most promising if high verification confidence is desired: random monitoring using door sensors; random monitoring using manned or unmanned aircraft; and continuous remote monitoring using unattended door sensors.

  5. Using NASTRAN to model missile inertia loads

    Science.gov (United States)

    Marvin, R.; Porter, C.

    1985-01-01

    An important use of NASTRAN is in the area of structural loads analysis on weapon systems carried aboard aircraft. The program is used to predict bending moments and shears in missile bodies, when subjected to aircraft induced accelerations. The missile, launcher and aircraft wing are idealized, using rod and beam type elements for solution economy. Using the inertia relief capability of NASTRAN, the model is subjected to various acceleration combinations. It is found to be difficult to model the launcher sway braces and hooks which transmit compression only or tension only type forces respectively. A simple, iterative process was developed to overcome this modeling difficulty. A proposed code modification would help model compression or tension only contact type problems.

  6. Ballistic Missile Defense: New Plans, Old Challenges

    Directory of Open Access Journals (Sweden)

    Elizabeth Zolotukhina

    2010-01-01

    Full Text Available On September 17, 2009—the 70th anniversary of the Soviet invasion of Poland in 1939 that marked the beginning of World War II—the Obama Administration announced its intention to shelve plans for the U.S. Ballistic Missile Defense (BMD that had been developed under former President George W. Bush. Pointing to a new intelligence assessment, President Obama argued that his predecessor's plan to deploy an X-band radar station outside of Prague, Czech Republic, and 10 two-stage interceptor missiles in Poland would not adequately protect America and its European allies from the Iranian threat and reiterated his opposition to utilizing unproven technology in any European BMD architecture.

  7. Reliability Simulation for a Missile Tank Under Random Loading

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    This paper presents a Monte-Carlo simulation method to calculate intensity relia- bility for a missile tank under random loading. The cumulative damage mathematical mod- el is established, and it adopts a direct simulation method to present random loading and o-riginal intensity for a missile tank. It can effectively predict intensity reliability for a missile tank in the environment of transport and flight.

  8. The Joint Cruise Missiles Project: An Acquisition History

    Science.gov (United States)

    1982-08-01

    his staff at the Air Force ALCM System Project Office. The authors are, of course , solely responsible for the accuracy and interpretation of the...meaning) Sea launched cruise missile (current meaning) SPOC System Project Officers Council SRAM Short range attack missile STCM Supersonic tactical...Council ( SPOC ), com- posed of the directors of the four major missile systems (consisting at that time of the GLCM, ship- and sub-launched SLCM, and the

  9. Theater Missile Defenses and U.S. Foreign Policy

    Science.gov (United States)

    1992-01-01

    and Joseph Rotblat (London: Macmillan Press, 1987), p. 171. 11 dowry " to alleviate European fears of being left defenseless as the U.S. retreated behind...surface missile, the design of which came from reverse-engineering of U.S. Nike-Hercules surface-to-air missiles. 59 India could be on the verge of...indigenous production with the testing of its Privthi missile. India has also demonstrated successful development of an indigenous space launch capacity

  10. On the Dynamic Stability of a Missile

    Directory of Open Access Journals (Sweden)

    K.C. Sharma

    1977-01-01

    Full Text Available The P-method given by Parks and Pritchard has been used to discuss the stability behaviour of a missile in free flight. General stability criteria for aerodynamic stabilisation have been obtained for slowly varying coefficients. The effect of pressure gradient on the stability of a coasting rocket has been explicitly examined. It is observed that the positive Magnus moment parameter ensures stability whereas a negative moment parameter would enhance the requirements of a larger stability margin.

  11. Cruise Missile Attack Are We Prepared

    Science.gov (United States)

    2007-03-09

    to be met to make its air and missile defense systems interoperable with others throughout the military because the requirements for SIAP [Single...Single Integrated Air Picture ( SIAP ) and Integrated Fire Control (IFC). SIAP “is the product of fused, near real-time and real-time data from...guidance of the Assistant Secretary of the Army for Acquisition, Logistics, and Technology (ASAALT), the Joint SIAP System Engineering Organization (JSSEO

  12. Sustainability Of The 21M Missile Maintainer

    Science.gov (United States)

    2016-02-16

    considering alternative career field models for missile maintenance officers. Benefits can include discovering lessons learned and best practices to improve...entire ICBM community in mitigating today’s problems and securing the confidence of the service and public. Introduction Mission failure has...which are applied to an alternative ICBM career field model . The paper closes in offering conclusions and recommendations about improving the health

  13. The Future of Theater Missile Defense

    Science.gov (United States)

    1994-06-01

    withERINT) 1,500 IVf 74C 1998 3.0 Navy Lower-Tier Defense 1,820 SO4 50* 1999° 3* THAAD(withTMD-GBR) 1,313 80 14 2001e 9.1 AdvaaoedCapabflitylMD Systems...Administration cannot, by itself, provide a sufficient buffer between theater and strategic missile defenses. Other limits must be included. Finally, the

  14. The Evolution of the Cruise Missile

    Science.gov (United States)

    1985-09-01

    device as a target in operations with the cartier Ranger in August, 1938. These and subqueat practice sessions revealed shockingly poor US Navy... market within a very short time." TIhe author speculated that the device could destroy an entire town as far as 100 miks away with no loss te the...downed 72.8 percent of the 125 missiles observed. Nevertheless, one flying bomb hit Smithfield Market on 8 March, causing 233 casualties.61 In all, the

  15. Intelligent Design and Implementation of Missile Fire Control System

    Institute of Scientific and Technical Information of China (English)

    XIE Chun-si; WANG Min-qing; LI Wei-hai; LIU Xi-zuo; JIN Liang-an

    2006-01-01

    Missile fire control system is the core of ship-based missile weapon system, whose safeguard levelhas direct relation with the attack ability of naval vessels. After a long period of deep investigation and research, it was found that, in one missile fire control system, there are such problems as single safeguard system, low ratio of cost to efficiency, etc. By adopting intelligent control techniques and many measures to multiple securities, the new type of assistant system is designed, some difficult problems are solved, such as fixed project channel and unitary means of missiles, which can make the equipment carry out combat mission reliably and continuously.

  16. Absolute and contrast infrared signatures from missile noses

    Science.gov (United States)

    Tofani, Alessandro

    1990-10-01

    The infrared radiant intensity and radiative contrast produced by the aerodynamic and solar heating of missile noses have been obtained by computer simulating the corresponding temperature distributions and by taking into account the effects of both atmosphere (absorption and self-emission) and target geometry (distance, aspect and elevation angles). Six target classes have been considered, including cruise missiles, air-to-air and surface-to-surface missiles, and ballistic missiles. The comparison between radiative quantities in the 3 to 5 μm and S to 12 μm atmospheric transmittance windows gives the optimum spectral band for target detection in each point of its trajectory.

  17. Multiplex immunoassay for Lyme disease using VlsE1-IgG and pepC10-IgM antibodies: improving test performance through bioinformatics.

    Science.gov (United States)

    Porwancher, Richard B; Hagerty, C Greg; Fan, Jianqing; Landsberg, Lisa; Johnson, Barbara J B; Kopnitsky, Mark; Steere, Allen C; Kulas, Karen; Wong, Susan J

    2011-05-01

    The Centers for Disease Control and Prevention currently recommends a 2-tier serologic approach to Lyme disease laboratory diagnosis, comprised of an initial serum enzyme immunoassay (EIA) for antibody to Borrelia burgdorferi followed by supplementary IgG and IgM Western blotting of EIA-positive or -equivocal samples. Western blot accuracy is limited by subjective interpretation of weakly positive bands, false-positive IgM immunoblots, and low sensitivity for detection of early disease. We developed an objective alternative second-tier immunoassay using a multiplex microsphere system that measures VlsE1-IgG and pepC10-IgM antibodies simultaneously in the same sample. Our study population comprised 79 patients with early acute Lyme disease, 82 patients with early-convalescent-phase disease, 47 patients with stage II and III disease, 34 patients post-antibiotic treatment, and 794 controls. A bioinformatic technique called partial receiver-operator characteristic (ROC) regression was used to combine individual antibody levels into a single diagnostic score with a single cutoff; this technique enhances test performance when a high specificity is required (e.g., ≥ 95%). Compared to Western blotting, the multiplex assay was equally specific (95.6%) but 20.7% more sensitive for early-convalescent-phase disease (89.0% versus 68.3%, respectively; 95% confidence interval [95% CI] for difference, 12.1% to 30.9%) and 12.5% more sensitive overall (75.0% versus 62.5%, respectively; 95% CI for difference, 8.1% to 17.1%). As a second-tier test, a multiplex assay for VlsE1-IgG and pepC10-IgM antibodies performed as well as or better than Western blotting for Lyme disease diagnosis. Prospective validation studies appear to be warranted.

  18. Multiplex Immunoassay for Lyme Disease Using VlsE1-IgG and pepC10-IgM Antibodies: Improving Test Performance through Bioinformatics ▿

    Science.gov (United States)

    Porwancher, Richard B.; Hagerty, C. Greg; Fan, Jianqing; Landsberg, Lisa; Johnson, Barbara J. B.; Kopnitsky, Mark; Steere, Allen C.; Kulas, Karen; Wong, Susan J.

    2011-01-01

    The Centers for Disease Control and Prevention currently recommends a 2-tier serologic approach to Lyme disease laboratory diagnosis, comprised of an initial serum enzyme immunoassay (EIA) for antibody to Borrelia burgdorferi followed by supplementary IgG and IgM Western blotting of EIA-positive or -equivocal samples. Western blot accuracy is limited by subjective interpretation of weakly positive bands, false-positive IgM immunoblots, and low sensitivity for detection of early disease. We developed an objective alternative second-tier immunoassay using a multiplex microsphere system that measures VlsE1-IgG and pepC10-IgM antibodies simultaneously in the same sample. Our study population comprised 79 patients with early acute Lyme disease, 82 patients with early-convalescent-phase disease, 47 patients with stage II and III disease, 34 patients post-antibiotic treatment, and 794 controls. A bioinformatic technique called partial receiver-operator characteristic (ROC) regression was used to combine individual antibody levels into a single diagnostic score with a single cutoff; this technique enhances test performance when a high specificity is required (e.g., ≥95%). Compared to Western blotting, the multiplex assay was equally specific (95.6%) but 20.7% more sensitive for early-convalescent-phase disease (89.0% versus 68.3%, respectively; 95% confidence interval [95% CI] for difference, 12.1% to 30.9%) and 12.5% more sensitive overall (75.0% versus 62.5%, respectively; 95% CI for difference, 8.1% to 17.1%). As a second-tier test, a multiplex assay for VlsE1-IgG and pepC10-IgM antibodies performed as well as or better than Western blotting for Lyme disease diagnosis. Prospective validation studies appear to be warranted. PMID:21367982

  19. Summary Report for Capsule Dry Storage Project

    Energy Technology Data Exchange (ETDEWEB)

    JOSEPHSON, W S

    2003-09-04

    There are 1.936 cesium (Cs) and strontium (Sr) capsules stored in pools at the Waste Encapsulation and Storage Facility (WESF). These capsules will be moved to dry storage on the Hanford Site as an interim measure to reduce risk. The Cs/Sr Capsule Dry Storage Project (CDSP) is conducted under the assumption the capsules will eventually be moved to the repository at Yucca Mountain, and the design criteria include requirements that will facilitate acceptance at the repository. The storage system must also permit retrieval of capsules in the event vitrification of the capsule contents is pursued. A cut away drawing of a typical cesium chloride (CsCI) capsule and the capsule property and geometry information are provided in Figure 1.1. Strontium fluoride (SrF{sub 2}) capsules are similar in design to CsCl capsules. Further details of capsule design, current state, and reference information are given later in this report and its references. Capsule production and life history is covered in WMP-16938, Capsule Characterization Report for Capsule Dry Storage Project, and is briefly summarized in Section 5.2 of this report.

  20. Trident II (D-5) Sea Launched Ballistic Missile UGM 133A (Trident II Missile)

    Science.gov (United States)

    2015-12-01

    on quality training and unscheduled down time on the rocket motor precision drilling machine . Trident II Missile December 2015 SAR March 17, 2016...chocks, Third Stage (TS) dollies and TS Motor Supports and completion of machining and welding for Aerospike Protective Caps; 2) Early delivery of

  1. Common Ada Missile Packages. Phase 2. (CAMP-2). Volume 2. 11th Missile Demonstration

    Science.gov (United States)

    1988-11-01

    bii t Ui< «i > i martial Sanaor Aaaaaibly 11th Miaaila Syatam Figure 1. 11th Missile Hardware Design TABLE 2. PROCESSORS AND THEIR FUNCTIONS...ualng Two Value Aretangant Coaputa Wander Ailauth Angle ualng Two Value Aretangant SUBTOTALS 132 14» 20 »003 North »olntlng HaTlgatlon » arta Coaputa

  2. Introduction of Women into Titan II Missile Operations.

    Science.gov (United States)

    1981-03-01

    areas (weapons system orientation: mnaintenance management. electronics principles , and technical publications. facility systems and missile Sfstents...Management. Electronics Principles . Technical Publications 97.00 2.63 94.04 5.27 2.31 Facility Systems 92.25 4.61 93.2) 5.80 -.62 Missile Systems 96.67 2.90

  3. Aerodynamic performances of cruise missile flying above local terrain

    Science.gov (United States)

    Ahmad, A.; Saad, M. R.; Che Idris, A.; Rahman, M. R. A.; Sujipto, S.

    2016-10-01

    Cruise missile can be classified as a smart bomb and also Unmanned Aerial Vehicle (UAV) due to its ability to move and manoeuvre by itself without a pilot. Cruise missile flies in constant velocity in cruising stage. Malaysia is one of the consumers of cruise missiles that are imported from other nations, which can have distinct geographic factors including their local terrains compared to Malaysia. Some of the aerodynamic performances of missile such as drag and lift coefficients can be affected by the local geographic conditions in Malaysia, which is different from the origin nation. Therefore, a detailed study must be done to get aerodynamic performance of cruise missiles that operate in Malaysia. The effect of aerodynamic angles such as angle of attack and side slip can be used to investigate the aerodynamic performances of cruise missile. Hence, subsonic wind tunnel testings were conducted to obtain the aerodynamic performances of the missile at various angle of attack and sideslip angles. Smoke visualization was also performed to visualize the behaviour of flow separation. The optimum angle of attack found was at α=21° and side slip, β=10° for optimum pitching and yawing motion of cruise missile.

  4. A History of Polish Anti-Missile Defenses

    Science.gov (United States)

    1994-01-01

    tanks, 1,750 armored personnel carriers, transport 11 aircraft, helicopters, and several naval craft.ŕ The WOPK provided air space management and...targets which included missile-related threats.90 Comunnication was an integral part of missile warning. Since Poland’s WOPK was part of the PVOS, Warsaw

  5. Capsule endoscopy of the esophagus.

    Science.gov (United States)

    Waterman, Matti; Gralnek, Ian M

    2009-08-01

    Video capsule endoscopy has acquired wide clinical acceptance since its the US Food and Drug Administration approval in 2001. Recently, the technology of video capsule endoscopy has been adapted to other organs in the gastrointestinal tract, including the esophagus and colon. In this review, we discuss esophageal capsule endoscopy (ECE)-the procedure, its indications, contraindications, safety, and future applications. ECE is a minimally invasive procedure that uses special video capsules with ability to acquire images from 2 cameras with high image storing speed of 14 to 18 frames per second. A special ingestion procedure allows for prolonged esophageal transit time and an optimized view of the gastroesophageal junction. ECE has been shown to have moderately high sensitivity and accuracy in the diagnosis and surveillance of Barrett esophagus in patients with gastroesophageal reflux disease but has not demonstrated superiority to esogastroduodenoscopy in cost-effectiveness models. In patients with portal hypertension, ECE has a sensitivity of 63% to 100% for screening of esophageal varices, but does not seem to be superior to esogastroduodenoscopy in its cost-effectiveness. No serious complications have been reported after ECE although a low rate of esophageal capsule retention (0.7% to 2.2%) has been reported, usually because of unsuspected esophageal strictures. Contraindications to capsule endoscopy include known or suspected gastrointestinal and esophageal obstruction, strictures, or fistulas, intestinal pseudoobstruction, and children under 10 years of age. It is expected that improvements in imaging technology will improve the accuracy of ECE with the development of immunological-based and chemical-based diagnostic capabilities.

  6. Triggered Release from Polymer Capsules

    Energy Technology Data Exchange (ETDEWEB)

    Esser-Kahn, Aaron P. [Univ. of Illinois, Urbana, IL (United States). Beckman Inst. for Advanced Science and Technology and Dept. of Chemistry; Odom, Susan A. [Univ. of Illinois, Urbana, IL (United States). Beckman Inst. for Advanced Science and Technology and Dept. of Chemistry; Sottos, Nancy R. [Univ. of Illinois, Urbana, IL (United States). Beckman Inst. for Advanced Science and Technology and Dept. of Materials Science and Engineering; White, Scott R. [Univ. of Illinois, Urbana, IL (United States). Beckman Inst. for Advanced Science and Technology and Dept. of Aerospace Engineering; Moore, Jeffrey S. [Univ. of Illinois, Urbana, IL (United States). Beckman Inst. for Advanced Science and Technology and Dept. of Chemistry

    2011-07-06

    Stimuli-responsive capsules are of interest in drug delivery, fragrance release, food preservation, and self-healing materials. Many methods are used to trigger the release of encapsulated contents. Here we highlight mechanisms for the controlled release of encapsulated cargo that utilize chemical reactions occurring in solid polymeric shell walls. Triggering mechanisms responsible for covalent bond cleavage that result in the release of capsule contents include chemical, biological, light, thermal, magnetic, and electrical stimuli. We present methods for encapsulation and release, triggering methods, and mechanisms and conclude with our opinions on interesting obstacles for chemically induced activation with relevance for controlled release.

  7. The science, technology, and politics of ballistic missile defense

    Science.gov (United States)

    Coyle, Philip E.

    2014-05-01

    America's missile defense systems are deployed at home and abroad. This includes the Groundbased Missile Defense (GMD) system in Alaska and California, the Phased Adaptive Approach in Europe (EPAA), and regional systems in the Middle East and Asia. Unfortunately these systems lack workable architectures, and many of the required elements either don't work or are missing. Major review and reconsideration is needed of all elements of these systems. GMD performance in tests has gotten worse with time, when it ought to be getting better. A lack of political support is not to blame as the DoD spends about 10 billion per year, and proposes to add about 5 billion over the next five years. Russia objects to the EPAA as a threat to its ICBM forces, and to the extensive deployment of U.S. military forces in countries such as Poland, the Czech Republic and Romania, once part of the Soviet Union. Going forward the U.S. should keep working with Russia whose cooperation will be key to diplomatic gains in the Middle East and elsewhere. Meanwhile, America's missile defenses face an enduring set of issues, especially target discrimination in the face of attacks designed to overwhelm the defenses, stage separation debris, chaff, decoys, and stealth. Dealing with target discrimination while also replacing, upgrading, or adding to the many elements of U.S. missiles defenses presents daunting budget priorities. A new look at the threat is warranted, and whether the U.S. needs to consider every nation that possesses even short-range missiles a threat to America. The proliferation of missiles of all sizes around the world is a growing problem, but expecting U.S. missile defenses to deal with all those missiles everywhere is unrealistic, and U.S. missile defenses, effective or not, are justifying more and more offensive missiles.

  8. The science, technology, and politics of ballistic missile defense

    Energy Technology Data Exchange (ETDEWEB)

    Coyle, Philip E. [Center for Arms Control and Non-Proliferation, Washington, DC (United States)

    2014-05-09

    America's missile defense systems are deployed at home and abroad. This includes the Groundbased Missile Defense (GMD) system in Alaska and California, the Phased Adaptive Approach in Europe (EPAA), and regional systems in the Middle East and Asia. Unfortunately these systems lack workable architectures, and many of the required elements either don't work or are missing. Major review and reconsideration is needed of all elements of these systems. GMD performance in tests has gotten worse with time, when it ought to be getting better. A lack of political support is not to blame as the DoD spends about $10 billion per year, and proposes to add about $5 billion over the next five years. Russia objects to the EPAA as a threat to its ICBM forces, and to the extensive deployment of U.S. military forces in countries such as Poland, the Czech Republic and Romania, once part of the Soviet Union. Going forward the U.S. should keep working with Russia whose cooperation will be key to diplomatic gains in the Middle East and elsewhere. Meanwhile, America's missile defenses face an enduring set of issues, especially target discrimination in the face of attacks designed to overwhelm the defenses, stage separation debris, chaff, decoys, and stealth. Dealing with target discrimination while also replacing, upgrading, or adding to the many elements of U.S. missiles defenses presents daunting budget priorities. A new look at the threat is warranted, and whether the U.S. needs to consider every nation that possesses even short-range missiles a threat to America. The proliferation of missiles of all sizes around the world is a growing problem, but expecting U.S. missile defenses to deal with all those missiles everywhere is unrealistic, and U.S. missile defenses, effective or not, are justifying more and more offensive missiles.

  9. Photon Production Within Storage Capsules

    CERN Document Server

    Rittmann, P D

    2003-01-01

    This report provides tables and electronic worksheets that list the photon production rate within SrF2 and CsC1 storage capsules, particularly the continuous spectrum of bremsstrahlung photons from the slowing down of the emitted electrons (BREMCALC).

  10. Capsule endoscopy in pediatric patients

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Wireless capsule endoscope (WCE) for the investigation of the small bowel is an approved technique both in adults and children (more than 10 years old). The present review provides data on the indications, diagnostic yield, adverse events and limitations of the WCE technique in children and tries to predict the future of WCE usage in this population of patients.

  11. Recent Advances in Antitank Guided Missile Systems

    Directory of Open Access Journals (Sweden)

    N. R. Iyer

    1995-07-01

    Full Text Available The recent advances in tactical antitank guided missile (ATGM systems are discussed. The main driving factors for the technological advances towards realisation of third generation ATGM systems have been the more demanding operational needs of the user services and limitations of earlier generation ATGM systems. The tasks of system design, hardware realisation, integration, testing and qualification have become extremely challenging to meet these stringent operational requirements. The technologies required to be mobilised for meeting these operational requirements and performance envelope and satisfying the operational and logistics constraints are again very demanding. The high technology content and the high level of performance required out of the subsystems have led to the present generation missile systems. The evolution from the earlier generations to current systems has been briefly discussed. Imaging infrared (IIR and Millimetre wave (MMW guidance systems employed for achieving the fire and forget capability of the third generation ATGM are described with specific reference to progress achieved so far. Translating the mission requirements to preliminary system specifications is another area wherein an innovative approach only can lead to meet the multiple performance criteria. Performance growth profile and emerging trends in ATGM systems are also analysed.

  12. CT analysis of missile head injury

    Energy Technology Data Exchange (ETDEWEB)

    Besenski, N. [Dept. of Radiology, Zagreb Univ. Hospital Rebro (Croatia); Jadro-Santel, D. [Dept. of Neuropathology, Zagreb Univ. Hospital Rebro (Croatia); Jelavic-Koic, F. [Dept. of Radiology, General Hospital Sveti Duh, Zagreb (Croatia); Pavic, D. [Dept. of Neuropathology, Zagreb Univ. Hospital Rebro (Croatia); Mikulic, D. [Zagreb School of Medicine (Croatia); Glavina, K. [Dept. of Radiology, Clinical Hospital, Osijek (Croatia); Maskovic, J. [Dept. of Radiology, Clinical Hospital, Split (Croatia)

    1995-04-01

    Between August 1991 and December 1992, CT was performed in 154 patients who had suffered missile head injury during the war in the Republic of Croatia. In 54% CT was performed 1-24 h after injury, and in 27% follow-up CT was also obtained. The wounds were penetrating, tangential or perforating (45%, 34% and 21%, respectively). Haemorrhage was the most frequent lesion in the brain (84%). Follow-up CT evolution of haemorrhage, oedema, cerebritis, abscess, secondary vascular lesions, necrosis, encephalomalacia and hydrocephalus. The most dynamic changes occurred 7-14 days after injury. In 14% of cases, deep cerebral lesions were found in the corpus callosum, septum pellucidum periventricular region and pons, although bone and shell fragments were in a different part of the brain parenchyma. Such lesions were found in penetrating injuries only. CT proved very useful for assessing the extent and type of lesions. Although different mechanisms of brain damage in missile head injury are known, here they are, to the best of our knowledge, shown for the first time by CT. (orig.)

  13. Modelling cavitating flow around underwater missiles

    Directory of Open Access Journals (Sweden)

    Fabien Petitpas

    2011-12-01

    Full Text Available The diffuse interface model of Saurel et al. (2008 is used for the computation of compressible cavitating flows around underwater missiles. Such systems use gas injection and natural cavitation to reduce drag effects. Consequently material interfaces appear separating liquid and gas. These interfaces may have a really complex dynamics such that only a few formulations are able to predict their evolution. Contrarily to front tracking or interface reconstruction method the interfaces are computed as diffused numerical zones, that are captured in a routinely manner, as is done usually with gas dynamics solvers for shocks and contact discontinuity. With the present approach, a single set of partial differential equations is solved everywhere, with a single numerical scheme. This leads to very efficient solvers. The algorithm derived in Saurel et al. (2009 is used to compute cavitation pockets around solid bodies. It is first validated against experiments done in cavitation tunnel at CNU. Then it is used to compute flows around high speed underwater systems (Shkval-like missile. Performance data are then computed showing method ability to predict forces acting on the system.

  14. Gauging the Influence of Technology on Tactical Missiles of the Future(Short Communication

    Directory of Open Access Journals (Sweden)

    Mark L. Bundy

    2002-01-01

    Full Text Available Tactical missiles, carrying kinetic energy, high explosives, or multiple submunitions are an integral part of the current and future US Army weapons inventory. Naturally, the number of missiles that can be stowed on any mobile launch platform depends on the size of the missile. Advances in rocket propulsion efficiency and improvements in guidance systems may make it possible to reduce missile size without a proportionate decrease in effectiveness. A primitive I-DOF computer model is used here to show how advances in missile technology might allow smaller missiles in the future to carry out the mission of today's larger missiles. A scaled-down version of a typical current generation missile is taken as the next generation missile. Hypothetical improvements in this smaller missile are then chosen in four basic areas-propellant impulse, burn time, weight fraction, and aerodynamic drag.-with the effects on lethality reported in a nondimensional format.

  15. Innovation in Aerodynamic Design Features of Soviet Missiles

    Science.gov (United States)

    Spearman, M. Leroy

    2006-01-01

    Wind tunnel investigations of some tactical and strategic missile systems developed by the former Soviet Union have been included in the basic missile research programs of the NACA/NASA. Studies of the Soviet missiles sometimes revealed innovative design features that resulted in unusual or unexpected aerodynamic characteristics. In some cases these characteristics have been such that the measured performance of the missile exceeds what might have been predicted. In other cases some unusual design features have been found that would alleviate what might otherwise have been a serious aerodynamic problem. In some designs, what has appeared to be a lack of refinement has proven to be a matter of expediency. It is a purpose of this paper to describe some examples of unusual design features of some Soviet missiles and to illustrate the effectiveness of the design features on the aerodynamic behavior of the missile. The paper draws on the experience of the author who for over 60 years was involved in the aerodynamic wind tunnel testing of aircraft and missiles with the NACA/NASA.

  16. A Low-Visibility Force Multiplier: Assessing China’s Cruise Missile Ambitions

    Science.gov (United States)

    2014-04-01

    and ballistic missile force will be far less effective than its numbers would indicate. 18 Forensic data may not have been collected and analyzed for...and ballistic missiles; some has focused on Chinese efforts to develop an antiship ballistic missile that might tar- get U.S. aircraft carriers. One...electronically scanned array AIP air-independent propulsion ARM antiradiation missile ASAT antisatellite ASBM antiship ballistic missile ASCM antiship

  17. Strapdown inertial systems applications for tactical missiles (stand-off missiles)

    Science.gov (United States)

    Puech

    1986-06-01

    Strapdown Inertial Systems (SDIS) are particularly well suited for tactical standoff missile applications. This certainty was made clear by several years of theoretical design work and trials. Initial theoretical work made wide use of parameters giving detailed definition of missile trajectories and motions as obtained from measurements made on weapon systems then in development or production. Sensors (principally gyroscopes) were laboratory tested. These preliminary design efforts led to selection of various technologies such as the laser gyro and the mechanical gyro, each being adapted to the weapon system in question. Share-out of functions between various equipment items was defined. Comparison of the advantages and disadvantages of these technologies shows that today the laser gyro is principally retained for high and medium range levels of precision, with the mechanical (spin-stabilized) gyro serving in the medium and low precision range. Since requirements are ever increasing in the fields of dynamic performance and robustness, it is here that most progress is expected.

  18. TOW Missile Pallet MIL-STD-1660 Tests

    Science.gov (United States)

    1993-08-01

    0 DTICS ELECTE FEB 2 19941 FINAL REPORT C U ow AUGUST 1993 (V V Lfl3 NNE REPORT NO. 93-23 TOW MISSILE PALLET MIL- STD -1660 TESTS Prepared for...TITLE gOnakde Secwir Casaftedon) TOW Missile Pallet MIL- STD -1660 Tests 12. PERSONAL AUTHOR(S) Jason B. Solberg 13s. TYPE OF REPORT 13b. TIME COVERED...and Engineering Center (ARDEC) to test the TOW missile pallet. This report contains the procedures, results, and recommendations from the MIL- STD

  19. Research on ballistic missile laser SIMU error propagation mechanism

    Institute of Scientific and Technical Information of China (English)

    Wei Shihui; Xiao Longxu

    2008-01-01

    It is necessary that the laser inertial system is used to further improve the fire accuracy and quick reaction capability in the ballistic missile strapdown inertial navigation system. According to the guidance con-trolling method and the output and error model of ballistic missile laser SIMU, the mathematical model of error propagation mechanism is set up and any transfer environmental function of error coefficient that affects the fire accuracy is deduced. Also, the missile longitudinal/lateral impact point is calculated using MATLAB. These estab-lish the technical foundation for further researching the dispersion characteristics of impact point and reducing the laser guidance error.

  20. Missile antenna pattern coordinate system and data formats

    Science.gov (United States)

    1993-08-01

    Antenna performance data pertains to missile, space, and aerodynamic vehicles' transmitting or receiving antennas used with range data collection, missile trajectory measurements, impact predictions, communications, or flight termination systems. As used in this document, the terms missile space vehicle, airborne, and aerodynamic vehicle are synonymous. This standard is intended to cover antennas for telemetry, pulsed radar beacons, continuous wave (CW) transponders, communication transmitters and receivers, command control/flight termination, receivers/decoders, pseudo random noise (PRN) ranging systems, and the Global Positioning System.

  1. Aerodynamic heating of ballistic missile including the effects of gravity

    Indian Academy of Sciences (India)

    S N Maitra

    2000-10-01

    The aerodynamic heating of a ballistic missile due to only convection is analysed taking into consideration the effects of gravity. The amount of heat transferred to the wetted area and to the nose region has been separately determined, unlike A Miele's treatise without consideration of gravity. The peak heating ratesto the wetted area and to the nose of the missile are also investigated. Finally four numerical examples are cited to estimate the errors, in heat transfers and heating ratesto both wetted area and nose region of the missile, arising out of neglecting the gravitational forces.

  2. Regional Joint-Integrated Air and Missile Defense (RF-IAMD): An Operational Level Integrated Air and Missile Defense (IAMD) Command and Control (C2) Organization

    Science.gov (United States)

    2015-05-15

    the Naval Air and Missile Defense Command (NAMDC). NAMDC then began training field grade officers through a Weapons and Tactics Instructor ( WTI ...49 Integrated Air and Missile Defense (IAMD) Weapons and Tactics Instructor ( WTI ), Naval Air and Missile...and Missile Defense (IAMD) Weapons and Tactics Instructor ( WTI ). Accessed April 28, 2015. http://namdc.ahf.nmci.navy.mil/site%20pages/wti.htm

  3. Dynamic Simulation for Missile Erection System

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In order to study the dynamic characteristics of the missile erection system, it can be considered as a rigid-flexible coupling multi-body system. Firstly, the actual system is abstracted as an equal and simplified one and then the forces applied to it are analyzed. Secondly, the rigid-flexible coupling dynamic simulation for erection system is accomplished by use of the system simulation software, for example Pro/E, ADAMS, ANSYS, MATLAB/Simulink, etc. Finally, having the aid of simulation results, the kinetic and dynamic characteristics of the flexible bodies in erection system are analyzed.The simulation considering the erection system as a rigid-flexible coupling system can provide valuable results to the research of its kinetic, dynamic and vibrational characteristics.

  4. The Study of Tactical Missile's Airframe Digital Optimization Design

    Institute of Scientific and Technical Information of China (English)

    LUO Zhiqing; QIAN Airong; LI Xuefeng; GAO Lin; LEI Jian

    2006-01-01

    Digital design and optimal are very important in modern design. The traditional design methods and procedure are not fit for the modern missile weapons research and development. Digital design methods and optimal ideas were employed to deal with this problem. The disadvantages of the traditional missile's airframe design procedure and the advantages of the digital design methods were discussed. A new concept of design process reengineering (DPR) was put forward. An integrated missile airframe digital design platform and the digital design procedure, which integrated the optimization ideas and methods, were developed. Case study showed that the design platform and the design procedure could improve the efficiency and quality of missile's airframe design, and get the more reasonable and optimal results.

  5. Passive Acoustic Radar for Detecting Supersonic Cruise Missile

    Institute of Scientific and Technical Information of China (English)

    XIAO Feng; XIAO Hui

    2005-01-01

    A Passive Acoustic Radar is presented as a necessary complement to electromagnetic wave radar, which will be expected to be an effective means for detecting cruise missiles. Acoustic characteristics of supersonic flying projectiles with diverse shapes are expounded via experiment. It is pointed out that simulation experiment could be implemented using bullet or shell instead of cruise missile. Based on theoretical analysis and experiment, the "acoustic fingerprint" character of cruise missile is illustrated to identify it in a strong noise environment. After establishing a locating mathematical model,the technique of acoustic embattling is utilized to resolve a problem of confirming the time of early-warning, considering the fact that velocity of sound is much slower than that of light. Thereby, a whole system of passive acoustic radar for detecting supersonic cruise missile is formed.

  6. Vortex development on slender missiles at supersonic speeds

    Science.gov (United States)

    Allen, J. M.; Dillenius, M. F. E.

    1979-01-01

    A theoretical and experimental effort has been made to develop a vortex-prediction capability on circular and noncircular missiles at supersonic speeds. Predicted vortex patterns are computed by two linear-theory computer codes. One calculates the strengths and initial locations of the vortices, and the other calculates their trajectories. A short color motion picture has been produced from the calculations to illustrate the predicted vortex patterns on a typical missile. Experimental vapor-screen photographs are presented to show the longitudinal development of the vortices on a fin-control missile. Comparisons are made between these data and the predicted vortices to assess the accuracy of the theory. The theory appears to be fairly accurate in predicting the number, locations, and relative strengths of individual vortices which develop over the missile, but cannot predict vortex sheets or diffuse vorticity whenever they occur.

  7. Revolution in military affairs, missile defence and weapons in space ...

    African Journals Online (AJOL)

    Revolution in military affairs, missile defence and weapons in space: the US ... 1991 Gulf War that captured the imagination of military planners and policy makers, ... Firstly, very few countries have the financial and technological capability to ...

  8. Analysis of Nonlinear Missile Guidance Systems Through Linear Adjoint Method

    Directory of Open Access Journals (Sweden)

    Khaled Gamal Eltohamy

    2015-12-01

    Full Text Available In this paper, a linear simulation algorithm, the adjoint method, is modified and employed as an efficient tool for analyzing the contributions of system parameters to the miss - distance of a nonlinear time-varying missile guidance system model. As an example for the application of the linear adjoint method, the effect of missile flight time on the miss - distance is studied. Since the missile model is highly nonlinear and a time-varying linearized model is required to apply the adjoint method, a new technique that utilizes the time-reversed linearized coefficients of the missile as a replacement for the time-varying describing functions is applied and proven to be successful. It is found that, when compared with Monte Carlo generated results, simulation results of this linear adjoint technique provide acceptable accuracy and can be produced with much less effort.

  9. 77 FR 51970 - Renewal of Missile Defense Advisory Committee

    Science.gov (United States)

    2012-08-28

    ... configurations for the Ballistic Missile Defense System. The Committee shall be composed of not more than eleven... shall be comprised of no more than seven members. The primary focus of the Subcommittee is to conduct...

  10. Analysis and improvement of missile three-loop autopilots

    Institute of Scientific and Technical Information of China (English)

    Lin Defu; Fan Junfang; Qi Zaikang; Mou Yu

    2009-01-01

    characteristics from a two-loop autopilot with PI compensator.Both the two-loop and three-loop topologies can stabilize a static unstable missile.However,the finite actuator resource is the crucial factor dominating autopilot function.

  11. Design and Manufacturing Process for a Ballistic Missile

    Directory of Open Access Journals (Sweden)

    Zaharia Sebastian Marian

    2016-12-01

    Full Text Available Designing a ballistic missile flight depends on the mission and the stress to which the missile is subject. Missile’s requests are determined by: the organization of components; flight regime type, engine configuration and aerodynamic performance of the rocket flight. In this paper has been developed a ballistic missile with a smooth fuselage type, 10 control surfaces, 8 directional surfaces for cornering execution, 2 for maneuvers of execution to change the angle of incidence and 4 stabilizers direction. Through the technology of gluing and clamping of the shell and the use of titanium components, mass of ballistic missile presented a significant decrease in weight and a structure with high strength.

  12. Density Models for Velocity Analysis of Jet Impinged CEDM Missile

    Energy Technology Data Exchange (ETDEWEB)

    Jo, Won Ho; Kang, Tae Kyo; Cho, Yeon Ho; Chang, Sang Gyoon; Lee, Dae Hee [KEPCO EnC, Daejeon (Korea, Republic of)

    2015-05-15

    A control element drive mechanism (CEDM) can be a potential missile in the reactor head area during one of the postulated accidents. The CEDM is propelled by the high speed water jet discharged from a broken upper head nozzle. The jet expansion models to predict the missile velocity have been investigated by Kang et al. The previous work of Kang et al. showed a continuous increase in missile velocity as the CEDM missile travels. But it is not natural in that two phase flow from the nozzle break exit tends to disperse and the thrust force on the missile decreases along the distance of the travel. The jet flow also interacts with the air surrounding itself. Therefore, the density change has to be included in the estimation of the missile velocity. In this paper, two density change models of the water jet are introduced for the jet expansion models along with the distance from the nozzle break location. The first one is the direct approximation model. Two density approximation models are introduced to predict the CEDM missile velocity. For each model, the effects of the expanded jet area were included as the area ratio to the exit nozzle area. In direct approximation model, the results have showed rapid decrease in both density and missile velocity. In pressure approach model, the density change is assumed perfectly proportional to the pressure change, and the results showed relatively smooth change in both density and missile velocity comparing to the direct approximation model. Using the model developed by Kang et al.., the maximum missile velocity is about 4 times greater comparing to the pressure approach model since the density is constant as the jet density at the nozzle exit in their model. Pressure approach model has benefits in that this model adopted neither curve fitting nor extrapolation unlike the direct approximation model, and included the effects of density change which are not considered in the model developed by Kang et al. So, this model is

  13. Application of Computer Graphics to Performance Studies of Missile Warheads

    Directory of Open Access Journals (Sweden)

    K. Rama Rao

    1991-01-01

    Full Text Available Intercept geometry of target aircraft and missiles play an important role in determining the effectiveness of the warhead. Factors such as fragment spatial distribution profile, damage capabilities, target and missile characteristics have been considered and visualised through computer graphics and optimum intercept intercept angles have been arrived. Computer graphics has proved to be an important tool to enhance perception and conceptual design capabilities in the design environment.

  14. Patriot Advanced Capability-3 Missile Segment Enhancement (PAC-3 MSE)

    Science.gov (United States)

    2015-12-01

    sustainment reliability will exceed 20 hours MTBCMF. Will be demonstrated during Post Deployment Build -8 and Radar Digital Processor- Configuration...Technology and Logistics) PAC-3 MSE December 2015 SAR March 21, 2016 09:42:58 UNCLASSIFIED 4 COL John M. Eggert Lower Tier Project Office Building 5250...PAC-3 MSE) is a high velocity, hit-to-kill, surface -to-air missile capable of intercepting and destroying Tactical Ballistic Missiles (TBM) and air

  15. Information Management Principles Applied to the Ballistic Missile Defense System

    Science.gov (United States)

    2007-03-01

    of a BMDS. From this, the Army produced the Nike- Zeus system comprised of four radars, the Zeus missile, and a computer fire control system (General...made the Nike- Zeus our first National Missile Defense (NMD) system named Sentinel. The architecture was to cover 14 locations, 10 of which were...fostered the database system and representation of data in a hierarchy (Galliers & Leidner, 2003). Soon the limits of hierarchies were identified and

  16. 2014 Assessment of the Ballistic Missile Defense System (BMDS)

    Science.gov (United States)

    2015-03-23

    and necessary training aids and devices are not currently available and are not scheduled to become available for several years. Analyses of data...and Evaluation ( IOT &E) flight tests for the Aegis BMD 4.0 system and SM-3 Block IB missile. Outcome. INTERCEPT. The ship detected, tracked...missiles in a raid scenario. FTX-18 was the last of the three IOT &E test missions. Outcome. THREE SIMULATED INTERCEPTS. The ship detected, tracked

  17. Missile Defense Acquisition: Failure Is Not An Option

    Science.gov (United States)

    2016-01-26

    missile over Japan into the sea.1With the nation already possessing weapons of mass destruction (WMD), the test launch signaled their intention to...Korea stunned the world in 1998 with the launch of a Taepo Dong-1 ballistic missile over Japan into the sea.4With the nation already possessing nuclear...acquisition agility. MDA’s BMDS acquisition strategy must be timely, flexible, and agile or risk irrelevance. BMDS Layered Architecture Since the NMD

  18. Poly(N-isopropylacrylamide)/poly(dopamine) capsules.

    Science.gov (United States)

    Zhang, Yan; Teo, Boon M; Goldie, Kenneth N; Städler, Brigitte

    2014-05-20

    Polymer capsules are an interesting concept considered in nanobiotechnology. Approaches that facilitate their assembly remain sought after. Poly(dopamine) (PDA) has been considered and successfully applied in this context. We recently demonstrated that PDA could be copolymerized with different types of poly(N-isopropylacrylamide) (pNiPAAm) to assemble mixed films on planar substrates. Herein, we transferred this approach onto colloidal substrates and characterized the film thickness depending on the film composition and template particles size. While the membrane of capsules assembled using 5 μm template particles exhibited strong dependency on the film composition, smaller templates led to capsules with similar membrane thickness. We then compared the permeability of different capsules using fluorescently labeled dextran and fluorescein. We found that the permeability of capsules was heavily dependent on the polymer composition and the template particle size. These fundamental findings contribute to the potential of these capsules, assembled in one-step, for biomedical applications.

  19. The expectation of applying IR guidance in medium range air-to-air missiles

    Science.gov (United States)

    Li, Lijuan; Liu, Ke

    2016-10-01

    IR guidance has been widely used in near range dogfight air-to-air missiles while radar guidance is dominant in medium and long range air-to-air missiles. With the development of stealth airplanes and advanced electronic countermeasures, radar missiles have met with great challenges. In this article, the advantages and potential problems of applying IR guidance in medium range air-to-air missiles are analyzed. Approaches are put forward to solve the key technologies including depressing aerodynamic heating, increasing missiles' sensitivity and acquiring target after launch. IR medium range air-to-air missiles are predicted to play important role in modern battle field.

  20. Perform Ultrasonic Testing on Cs Capsule Overpacks

    Energy Technology Data Exchange (ETDEWEB)

    DAVIS, S.J.

    2000-04-06

    This procedure provides a safe, uniform method for the performance of the ultrasonic weld inspection of the Cesium capsule overpacks. The inspection system will detect cracks, lack of fusion, and lack of penetration. This computer controlled automated system will perform the examination once the capsule overpack has been placed in the pool cell. Examination of the capsule overpacks will be in accordance with drawing H-283014, REV. 0 ,and a certified NDE examiner will perform the test procedure, provide analysis, and test documentation.

  1. Colon Capsule Endoscopy: Review and Perspectives

    Directory of Open Access Journals (Sweden)

    David Friedel

    2016-01-01

    Full Text Available Colon capsule endoscopy utilizing PillCam COLON 2 capsule allows for visualization potentially of the entire colon and is currently approved for patients who cannot withstand the rigors of traditional optical colonoscopy (OC and associated sedation as well as those that had an OC that was incomplete for technical reasons other than a poor preparation. We will then describe the prior experience and current status of colon capsule endoscopy.

  2. Sensitive and specific serodiagnosis of Lyme disease by enzyme-linked immunosorbent assay with a peptide based on an immunodominant conserved region of Borrelia burgdorferi vlsE.

    Science.gov (United States)

    Liang, F T; Steere, A C; Marques, A R; Johnson, B J; Miller, J N; Philipp, M T

    1999-12-01

    VlsE, the variable surface antigen of Borrelia burgdorferi, contains an immunodominant conserved region named IR(6). In the present study, the diagnostic performance of a peptide enzyme-linked immunosorbent assay (ELISA) based on a 26-mer synthetic peptide (C(6)) with the IR(6) sequence was explored. Sensitivity was assessed with serum samples (n = 210) collected from patients with clinically defined Lyme disease at the acute (early localized or early disseminated disease), convalescent, or late disease phase. The sensitivities for acute-, convalescent-, and late-phase specimens were 74% (29 of 39), 85 to 90% (34 of 40 to 35 of 39), and 100% (59 of 59), respectively. Serum specimens from early neuroborreliosis patients were 95% positive (19 of 20), and those from an additional group of patients with posttreatment Lyme disease syndrome yielded a sensitivity of 62% (8 of 13). To assess the specificity of the peptide ELISA, 77 serum samples from patients with other spirochetal or chronic infections, autoimmune diseases, or neurologic diseases and 99 serum specimens from hospitalized patients in an area where Lyme disease is not endemic were examined. Only two potential false positives from the hospitalized patients were found, and the overall specificity was 99% (174 of 176). Precision, which was assessed with a panel of positive and negative serum specimens arranged in blinded duplicates, was 100%. Four serum samples with very high anti-OspA antibody titers obtained from four monkeys given the OspA vaccine did not react with the C(6) peptide. This simple, sensitive, specific, and precise ELISA may contribute to alleviate some of the remaining problems in Lyme disease serodiagnosis. Because of its synthetic peptide base, it will be inexpensive to manufacture. It also will be applicable to serum specimens from OspA-vaccinated subjects.

  3. Critical swelling of fluctuating capsules

    Science.gov (United States)

    Diamant, Haim; Haleva, Emir

    2009-03-01

    In many natural transport processes the solute molecules to be transported are encapsulated in semipermeable, flexible membrane vesicles of micron size. We study the swelling of such fluctuating capsules, as the number of encapsulated particles is increased, or the concentration of the outer solution is decreased. The approach to the maximum volume-to-area ratio and the associated buildup of membrane tension involve a continuous phase transition and follow universal scaling laws. The criticality and its features are model-independent, arising solely from the interplay between volume and surface degrees of freedom.ootnotetextE. Haleva and H. Diamant, Phys. Rev. Lett. 101, 078104 (2008).

  4. How helpful is capsule endoscopy to surgeons?

    Institute of Scientific and Technical Information of China (English)

    Osman Ersoy; Bulent Sivri; Yusuf Bayraktar

    2007-01-01

    Capsule endoscopy is a new technology that, for the first time, allows complete, non-invasive endoscopic imaging of the small bowel. The efficacy of capsule endoscopy in the diagnosis of suspected small bowel diseases has been established. Important applications for surgeons include observations of obscure gastrointestinal bleeding and small bowel neoplasms.

  5. The future of wireless capsule endoscopy

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    We outline probable and possible developments with wireless capsule endoscopy. It seems likely that capsule endoscopy will become increasingly effective in diagnostic gastrointestinal endoscopy. This will be attractive to patients especially for cancer or varices detection because capsule endoscopy is painless and is likely to have a higher take up rate compared to conventional colonoscopy and gastroscopy. Double imager capsules with increased frame rates have been used to image the esophagus for Barrett's and esophageal varices. The image quality is not bad but needs to be improved if it is to become a realistic substitute for flexible upper and lower gastrointestinal endoscopy. An increase in the frame rate, angle of view, depth of field, image numbers, duration of the procedure and improvements in illumination seem likely. Colonic, esophageal and gastric capsules will improve in quality, eroding the supremacy of flexible endoscopy, and become embedded into screening programs. Therapeutic capsules will emerge with brushing, cytology, fluid aspiration, biopsy and drug delivery capabilities. Electrocautery may also become possible. Diagnostic capsules will integrate physiological measurements with imaging and optical biopsy, and immunologic cancer recognition. Remote control movement will improve with the use of magnets and/or electrostimulation and perhaps electromechanical methods. External wireless commands will influence capsule diagnosis and therapy and will increasingly entail the use of real-time imaging. However, it should be noted that speculations about the future of technology in any detail are almost always wrong.

  6. Intrauterine fertilization capsules--a clinical trial

    DEFF Research Database (Denmark)

    Lenz, S; Lindenberg, S; Sundberg, K

    1991-01-01

    chorionic gonadotropin. Oocytes were collected by ultrasonically guided transvaginal aspiration, and spermatozoa were prepared by swim-up technique. The gametes were placed in agar capsules 4 hr after oocyte collection, and the capsules were introduced to the uterine fundus using an insertion tube...

  7. Cooled and uncooled infrared detectors for missile seekers

    Science.gov (United States)

    Fraenkel, Rami; Haski, Jacob; Mizrahi, Udi; Shkedy, Lior; Shtrichman, Itay; Pinsky, Ephi

    2014-06-01

    Electro-optical missile seekers pose exceptional requirements for infrared (IR) detectors. These requirements include: very short mission readiness (time-to-image), one-time and relatively short mission duration, extreme ambient conditions, high sensitivity, fast frame rate, and in some cases small size and cost. SCD is engaged in the development and production of IR detectors for missile seeker applications for many years. 0D, 1D and 2D InSb focal plane arrays (FPAs) are packaged in specially designed fast cool-down Dewars and integrated with Joule-Thomson (JT) coolers. These cooled MWIR detectors were integrated in numerous seekers of various missile types, for short and long range applications, and are combat proven. New technologies for the MWIR, such as epi-InSb and XBn-InAsSb, enable faster cool-down time and higher sensitivity for the next generation seekers. The uncooled micro-bolometer technology for IR detectors has advanced significantly over the last decade, and high resolution - high sensitivity FPAs are now available for different applications. Their much smaller size and cost with regard to the cooled detectors makes these uncooled LWIR detectors natural candidates for short and mid-range missile seekers. In this work we will present SCD's cooled and uncooled solutions for advanced electro-optical missile seekers.

  8. Missile launch detection electric field perturbation experiment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Kane, R.J.; Rynne, T.M.

    1993-04-28

    The Lawrence Livermore National Laboratory and SARA Inc. participated in the ATMD missile launch activities that occurred at WSMR during January 1993. LLNL and SARA deployed sensors for monitoring of basic phenomena. An attempt was made to measure perturbations of the earth geo-potential during the launch of a Lance missile. The occurrence of the perturbation is expected from the conducting body of the missile and the exhaust plume. A set of voltage-probe antennas were used to monitor the local electric field perturbation from the launch at ranges of approximately 1 km. Examination of the data acquired during the launch period failed to show identifiable correlation of the field variations with the launch event. Three reasons are ascribed to this lack of event data: (1) The electric field potential variations have a limited spatial correlation length - the fields measured in one region have little correlation to measurements made at distances of a kilometer away. The potential variations are related to localized atmospheric disturbances and are generally unpredictable. A value for the spatial correlation length is also not known. (2) The conductivity of the plume and missile body are not adequate to produce a field perturbation of adequate magnitude. Phenomena related to the exhaust plume and missile may exist and be outside of the collection range of the equipment employed for these measurements. (3) The presence of 60 Hz power line noise was of sufficient magnitude to irreversibly contaminate measurements.

  9. Asia-Pacific Missile Defense Cooperation and the United States 2004-2005: A Mixed Bag

    Science.gov (United States)

    2005-02-01

    in cooperating with the United States on various missile defense -related programs. Such close friends and allies as South Korea and Taiwan have made...many local opponents of missile defense argue that the missile threat to Australia is quite low, particularly as North Korea does not yet possess any...2004 in cooperating with the United States. Overall, South Korea does not appear to regard the North Korean missile threat as very likely. Based on

  10. A Study of Age Demographics across the Aviation and Missile Materiel Enterprise

    Science.gov (United States)

    2016-03-31

    future Aviation and Missile ME may look like. The Defense Civilian Personnel Data System (DCPDS) Human Resource managers across the Aviation and...Missile ME use the Defense Civilian Personnel Data System (DCPDS) as the warehouse for storing employee information. Each of the five organizations...Aviation and Missile Life Cycle Management Command Public Affairs, 25 April 2016 AVIATION AND MISSILE MATERIEL ENTERPRISE DEMOGRAPHICS 2

  11. Thermoregulation of Capsule Production by Streptococcus pyogenes

    Science.gov (United States)

    Kang, Song Ok; Wright, Jordan O.; Tesorero, Rafael A.; Lee, Hyunwoo; Beall, Bernard; Cho, Kyu Hong

    2012-01-01

    The capsule of Streptococcus pyogenes serves as an adhesin as well as an anti-phagocytic factor by binding to CD44 on keratinocytes of the pharyngeal mucosa and the skin, the main entry sites of the pathogen. We discovered that S. pyogenes HSC5 and MGAS315 strains are further thermoregulated for capsule production at a post-transcriptional level in addition to the transcriptional regulation by the CovRS two-component regulatory system. When the transcription of the hasABC capsular biosynthetic locus was de-repressed through mutation of the covRS system, the two strains, which have been used for pathogenesis studies in the laboratory, exhibited markedly increased capsule production at sub-body temperature. Employing transposon mutagenesis, we found that CvfA, a previously identified membrane-associated endoribonuclease, is required for the thermoregulation of capsule synthesis. The mutation of the cvfA gene conferred increased capsule production regardless of temperature. However, the amount of the capsule transcript was not changed by the mutation, indicating that a post-transcriptional regulator mediates between CvfA and thermoregulated capsule production. When we tested naturally occurring invasive mucoid strains, a high percentage (11/53, 21%) of the strains exhibited thermoregulated capsule production. As expected, the mucoid phenotype of these strains at sub-body temperature was due to mutations within the chromosomal covRS genes. Capsule thermoregulation that exhibits high capsule production at lower temperatures that occur on the skin or mucosal surface potentially confers better capability of adhesion and invasion when S. pyogenes penetrates the epithelial surface. PMID:22615992

  12. 76 FR 63541 - Design-Basis Hurricane and Hurricane Missiles for Nuclear Power Plants

    Science.gov (United States)

    2011-10-13

    ...-2010-0288] Design-Basis Hurricane and Hurricane Missiles for Nuclear Power Plants AGENCY: Nuclear... Hurricane Missiles for Nuclear Power Plants.'' This regulatory guide provides licensees and applicants with... hurricane and design-basis hurricane-generated missiles that a nuclear power plant should be designed...

  13. The analysis of a generic air-to-air missile simulation model

    Science.gov (United States)

    Kaplan, Joseph A.; Chappell, Alan R.; Mcmanus, John W.

    1994-01-01

    A generic missile model was developed to evaluate the benefits of using a dynamic missile fly-out simulation system versus a static missile launch envelope system for air-to-air combat simulation. This paper examines the performance of a launch envelope model and a missile fly-out model. The launch envelope model bases its probability of killing the target aircraft on the target aircraft's position at the launch time of the weapon. The benefits gained from a launch envelope model are the simplicity of implementation and the minimal computational overhead required. A missile fly-out model takes into account the physical characteristics of the missile as it simulates the guidance, propulsion, and movement of the missile. The missile's probability of kill is based on the missile miss distance (or the minimum distance between the missile and the target aircraft). The problems associated with this method of modeling are a larger computational overhead, the additional complexity required to determine the missile miss distance, and the additional complexity of determining the reason(s) the missile missed the target. This paper evaluates the two methods and compares the results of running each method on a comprehensive set of test conditions.

  14. High performance infrared fast cooled detectors for missile applications

    Science.gov (United States)

    Reibel, Yann; Espuno, Laurent; Taalat, Rachid; Sultan, Ahmad; Cassaigne, Pierre; Matallah, Noura

    2016-05-01

    SOFRADIR was selected in the late 90's for the production of 320×256 MW detectors for major European missile programs. This experience has established our company as a key player in the field of missile programs. SOFRADIR has since developed a vast portfolio of lightweight, compact and high performance JT-based solutions for missiles. ALTAN is a 384x288 Mid Wave infrared detector with 15μm pixel pitch, and is offered in a miniature ultra-fast Joule- Thomson cooled Dewar. Since Sofradir offers both Indium Antimonide (InSb) and Mercury Cadmium Telluride technologies (MCT), we are able to deliver the detectors best suited to customers' needs. In this paper we are discussing different figures of merit for very compact and innovative JT-cooled detectors and are highlighting the challenges for infrared detection technologies.

  15. Flexible missile autopilot design studies with PC-MATLAB/386

    Science.gov (United States)

    Ruth, Michael J.

    1989-01-01

    Development of a responsive, high-bandwidth missile autopilot for airframes which have structural modes of unusually low frequency presents a challenging design task. Such systems are viable candidates for modern, state-space control design methods. The PC-MATLAB interactive software package provides an environment well-suited to the development of candidate linear control laws for flexible missile autopilots. The strengths of MATLAB include: (1) exceptionally high speed (MATLAB's version for 80386-based PC's offers benchmarks approaching minicomputer and mainframe performance); (2) ability to handle large design models of several hundred degrees of freedom, if necessary; and (3) broad extensibility through user-defined functions. To characterize MATLAB capabilities, a simplified design example is presented. This involves interactive definition of an observer-based state-space compensator for a flexible missile autopilot design task. MATLAB capabilities and limitations, in the context of this design task, are then summarized.

  16. Elastic constants of the human lens capsule.

    Science.gov (United States)

    Fisher, R F

    1969-03-01

    1. A technique is described whereby the elasticity of the human lens capsule has been determined at birth and throughout life. This technique requires three separate determinations: (a) thickness; (b) stress and strain; (c) Poisson's ratio; (a) the capsule was clamped between accurately perforated ground glass plates and its thickness determined by noting the change in depth of focus between Latex spherules adhering to its upper and lower surfaces; (b) the undisturbed capsule was then placed in a specially designed glass distension apparatus and the relationship between volume and pressure recorded when it was distended with isotonic saline. The permeability of the capsule was also measured; (c) in some cases Poisson's ratio was determined by measuring the change of thickness of the capsule and the height to which it rose when distended with isotonic saline at different pressures. An apparatus was designed for this purpose.2. The average thickness of the anterior capsule increases from birth until about the 60th year but thereafter it decreases slightly.3. Poisson's ratio was about 0.47 for both cat and human capsule, and no significant variations with age in human capsule could be detected.4. Corrected volume pressure curves obeyed Hook's law almost to the point of capsule rupture.5. In childhood Young's Modulus of elasticity is about 6 x 10(7) dyn/cm(2) and decreases to 3 x 10(7) dyn/cm(2) at 60 and 1.5 x 10(7) dyn/cm(2) in extreme old age.6. The ultimate tensile stress was 2.3 x 10(7) dyn/cm(2) in young capsules and 0.7 x 10(7) dyn/cm(2) in old ones. The maximum percentage elongation was 29 per cent and independent of age.7. The implications of these findings are discussed in relation to(a) the mechanical properties of the lens capsule;(b) the ageing of the lens capsule and basement membranes; and(c) the decrease in elasticity of the lens capsule as a cause of presbyopia.

  17. Evaluation of Impact Force of Missile Filled with Fluid

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyuk-Kee [Hyundai, Yongin (Korea, Republic of); Kim, Seung-Eock [Sejong University, Seoul (Korea, Republic of)

    2016-10-15

    In this paper, the effect of the fluid on the impact force was evaluated using the commercial software LS-DYNA. In order to verify the proposed finite element (FE) models, the impact force and impulse of the missiles filled with the fluid (wet missile) were investigated, and the analysis results were compared with the force plate tests conducted by VTT laboratory in Finland. A parametric study was performed to evaluate the impulse as per the position filled with the fluid and the impact velocity. The impulses of the wet missiles obtained from the parametric study were compared with those calculated by the modified Riera function. The effect of the fluid on the impact force was evaluated in this study. Based on this study, the following conclusions have been obtained: (1) The impulse/momentum ratios of the wet missiles filled with fluid in the front part were larger than those filled with fluid in the middle part. The difference was 5.5%, 5.3%, 6.2%, 3.8%, 2.9% and 1.0% for the impact velocities of 100 m/s, 110 m/s, 120 m/s, 130 m/s, 140 m/s, and 150 m/s, respectively. (2) The impulse/momentum ratios of the wet missiles by the FE analysis was larger than those by the modified Riera function up to 23.1% and 20.8%, respectively, when the fluid was filled in the front and middle parts. The modified Riera function underestimated the impulses of the wet missiles.

  18. Electric Loading Simulation System for Missile Wings and Rudders

    Institute of Scientific and Technical Information of China (English)

    QI Rong; LIN Hui; CHEN Ming

    2006-01-01

    The design and the realization of missile wings and rudders loading simulation system based on digital signal processor (DSP) TMS320LF2407 and direct torque control (DTC) servo driver ACS600 are discussed. The structure and opration principle for the system are presented. Speediness and elimination of superabundant torque are two key difficulties for electric loading simulation system. The method which can eliminate the superabundant torque is researched. Test results show the airflow resistance when missile wings and rudders are spreading can be rapidly simulated with high accuracy.

  19. Terrain Contour Matching (TERCOM): A Cruise Missile Guidance Aid

    Science.gov (United States)

    Golden, Joe P.

    1980-12-01

    The Cruise Missile is guided by an inertial guidance system aided by an updating technique called Terrain Contour Matching (TERCOM). Chance-Vought first proposed the terrain correlation technique in the late 1950's. Since that time TERCOM has evolved into a reliable, accurate, all weather, day and night method of position fixing and updating for cruise missiles. A brief history of TERCOM development will be presented giving results where possible. A description of TERCOM and how is works will be discussed. A snapshot of the present TERCOM status and future planned developments will be addressed.

  20. A METHOD IN SYSTEM DESIGN OF EJECTING DEVICES OF MISSILES

    Institute of Scientific and Technical Information of China (English)

    DaiLongcheng; XuanYimin

    2002-01-01

    Anew method in system design of ejecting devices of missiles is first presented.Some important points are dis-cussed,which guid the research and development of new ejecting devices of missileg,amd provid the foundation flr thw design of mew ejecting device is provided.The system design includes the distribution of techmology specifica-tion,3-D solid modeling of ejecting devices of missiles im-ported from abroad,the design of pmeumatic device sys-tem,the design of ejecting mechanism system,the predic-tion of reliability and the experimental analysis,etc.

  1. Heat Transfer Between a Missile's Combustion Chamber and the Warhead

    Institute of Scientific and Technical Information of China (English)

    赵永涛; 张奇; 白春华; 闫华

    2003-01-01

    Under higher temperatures the charge within a warhead will be subjected to physical and chemical changes, which will influence the security of the warhead launching process. In this paper the problem is studied adopting finite difference method for the case of a rocket-powered missile. Temperature distribution tables are given through quadrature experiments, and the results fit the actual measured values very well. The results also show that to ensure the launching security of rocket-powered missiles having warhead charge critical temperature close to about 60 ℃, the designer can select appropriate heat insulation structural parameters.

  2. Robust control for snake maneuver design of missile

    Science.gov (United States)

    Kun, Ya; Chen, Xin; Li, Chuntao

    2017-01-01

    For the performance of missile with high Mach number and strongly nonlinear dynamics, this paper uses robust control to design maneuver controller. Robust servomechanism linear quadratic regulator (RSLQR) control is used to form the inner loop and proportional-plus-integral (PI) control is used to provide yawing tracking with no error. Contrast simulations under three types of deviation have been done to confirm robustness of the RSLQR-plus-PI control. Simulation results shows that RSLQR-plus-PI control would resist the disturbance and maintain the properties of the controller, guarantee the robustness and stability of missile more effectively than pure PI control.

  3. Consolidation of data base for Army generalized missile model

    Science.gov (United States)

    Klenke, D. J.; Hemsch, M. J.

    1980-01-01

    Data from plume interaction tests, nose mounted canard configuration tests, and high angle of attack tests on the Army Generalized Missile model are consolidated in a computer program which makes them readily accessible for plotting, listing, and evaluation. The program is written in FORTRAN and will run on an ordinary minicomputer. It has the capability of retrieving any coefficient from the existing DATAMAN tapes and displaying it in tabular or plotted form. Comparisons of data taken in several wind tunnels and of data with the predictions of Program MISSILE2 are also presented.

  4. Lightweight, highly compressible, noncrystalline cellulose capsules.

    Science.gov (United States)

    Carrick, Christopher; Lindström, Stefan B; Larsson, Per Tomas; Wågberg, Lars

    2014-07-08

    We demonstrate how to prepare extraordinarily deformable, gas-filled, spherical capsules from nonmodified cellulose. These capsules have a low nominal density, ranging from 7.6 to 14.2 kg/m(3), and can be deformed elastically to 70% deformation at 50% relative humidity. No compressive strain-at-break could be detected for these dry cellulose capsules, since they did not rupture even when compressed into a disk with pockets of highly compressed air. A quantitative constitutive model for the large deformation compression of these capsules is derived, including their high-frequency mechanical response and their low-frequency force relaxation, where the latter is governed by the gas barrier properties of the dry capsule. Mechanical testing corroborated these models with good accuracy. Force relaxation measurements at a constant compression rendered an estimate for the gas permeability of air through the capsule wall, calculated to 0.4 mL μm/m(2) days kPa at 50% relative humidity. These properties taken together open up a large application area for the capsules, and they could most likely be used for applications in compressible, lightweight materials and also constitute excellent model materials for adsorption and adhesion studies.

  5. [Evaluation of nopal capsules in diabetes mellitus].

    Science.gov (United States)

    Frati Munari, A C; Vera Lastra, O; Ariza Andraca, C R

    1992-01-01

    To find out if commercial capsules with dried nopal (prickle-pear cactus, Opuntia ficus indica may have a role in the management of diabetes mellitus, three experiments were performed: 30 capsules where given in fasting condition to 10 diabetic subjects and serum glucose was measured through out 3 hours; a control test was performed with 30 placebo capsules. OGTT with previous intake of 30 nopal or placebo capsules was performed in ten healthy individuals. In a crossover and single blinded study 14 diabetic patients withdrew the oral hypoglycemic treatment and received 10 nopal or placebo capsules t.i.d. during one week; serum glucose, cholesterol and tryglycerides levels were measured before and after each one-week period. Five healthy subjects were also studied in the same fashion. Opuntia capsules did not show acute hypoglycemic effect and did not influence OGTT. In diabetic patients serum glucose, cholesterol and tryglycerides levels did not change with Opuntia, but they increased with placebo (P nopal, while cholesterol and triglycerides decreased (P < 0.01 vs. placebo). The intake of 30 Opuntia capsules daily in patients with diabetes mellitus had a discrete beneficial effect on glucose and cholesterol. However this dose is unpractical and at present it is not recommended in the management of diabetes mellitus.

  6. [Karyosphere capsule in Tribolium castaneum oocytes].

    Science.gov (United States)

    Batalova, F M; Bogoliubov, D S

    2013-01-01

    Structure and composition of the karyosphere (karyosome) capsule were studied in the oocytes of a laboratory insect, Tribolium castaneum, with the use of electron microscopy and immunoelectron cytochemistry. Basing on the study of nuclear structure dynamics, we distinguished 8 stages that characterize the period of oocyte growth. At the diplotene stage, T. castaneum oocyte chromosomes conjoin early into a compact karyosphere, but a significant chromatin condensation does not occur. The process of karyosphere formation is accompanied by the development of an extensive extrachromosome capsule surrounding chromatin. The capsule consists of a material of different morphological types. Significant molecular components of the T. castaneum karyosphere capsule are represented by the proteins of nuclear matrix including F-actin and lamin B. Besides the structural proteins, the Sm proteins of small nuclear (sn) RNPs and mature 2,2,7-trimethyl guanosine (TMG) 5'-capped snRNAs are revealed immunocytochemically in the karyosphere capsule. The obtained data can form a basis for further expansion of ideas on the functions of the karyosphere capsule as a specialized extrachromosomal nuclear domain of the oocytes. We believe that the T. castaneum karyosphere capsule plays not only a structural role, but may be involved directly in the processes related to gene expression.

  7. Design and Implementation of One Missile Visual Simulation System Based on OpenGL

    Institute of Scientific and Technical Information of China (English)

    GAO Ying; ZHANG Pu-zhao; PENG Yu-xin; HUANG Jian-guo

    2007-01-01

    The implementation of a missile's visual simulation system is explained that is developed with OpenGL(open graphic library) and the flight path and flight carriage in different stages of the missile are displayed. The establishment problems of the 3D scene are circumstantiated including the construction and redeployment of the model, creation of the virtual scene, setting of the multi-viewports and multi-windows etc. The missile's data driver, system flow, the modules and their mutual relations of the missile visual simulation system are discussed. The missile flight simulation results and effect of the scenes are given.

  8. Research on image fusion of missile team based on multi-agent cooperative blackboard model

    Science.gov (United States)

    Sen, Guo; Munan, Li

    The target of cooperative engagement of missile teams is to furthest improve hit rate of target according to communication and cooperation among missiles. In this paper the problems of image fusion between missile teams in complex combat environment was analyzed, after which an muti-agent blackboard cooperative model was presented and a public information platform of missile team is built according to this model. Through these, the fusion of images taken from muti-sensor of missiles can be realized and the hit rate of attacking target will be improved. At last, an simulation experiment were performed, and the feasibility of the method is proved by simulation experiment.

  9. Tag gas capsule with magnetic piercing device

    Science.gov (United States)

    Nelson, Ira V.

    1976-06-22

    An apparatus for introducing a tag (i.e., identifying) gas into a tubular nuclear fuel element. A sealed capsule containing the tag gas is placed in the plenum in the fuel tube between the fuel and the end cap. A ferromagnetic punch having a penetrating point is slidably mounted in the plenum. By external electro-magnets, the punch may be caused to penetrate a thin rupturable end wall of the capsule and release the tag gas into the fuel element. Preferably the punch is slidably mounted within the capsule, which is in turn loaded as a sealed unit into the fuel element.

  10. An analysis of the common missile and TOW 2B on the Stryker anti-tank guided missile platform, using the Janus simulation

    OpenAIRE

    2002-01-01

    Approved for public release; distribution in unlimited. The U.S. Army is beginning to field the first of six Stryker Brigade Combat Teams (SBCTs) and equip the organic Anti-Tank (AT) Company of the Brigade with the LAV III Anti-Tank Guided Missile (ATGM) Platform and the Tube-Launched, Optically-Tracked, Wire-Guided 2B (TOW 2B) missile system. A developmental effort is currently underway to replace the aging TOW 2B and Hellfire missile systems with a common missile that meets both ground...

  11. 21 CFR 520.1660b - Oxytetracycline hydrochloride capsules.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Oxytetracycline hydrochloride capsules. 520.1660b Section 520.1660b Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Oxytetracycline hydrochloride capsules. (a) Specifications. The drug is in capsule form with each capsule...

  12. 21 CFR 520.1803 - Piperazine citrate capsules.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Piperazine citrate capsules. 520.1803 Section 520... capsules. (a) Specifications. Piperazine citrate capsules contain piperazine citrate equivalent to 140 milligrams of piperazine base in each capsule. (b) Sponsor. See No. 021091 in § 510.600(c) of this chapter...

  13. 21 CFR 520.446 - Clindamycin capsules and tablets.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Clindamycin capsules and tablets. 520.446 Section... capsules and tablets. (a) Specifications—(1) Each capsule contains the equivalent of 25, 75, 150, or 300... 150 mg clindamycin as the hydrochloride salt. (3) Each capsule contains the equivalent of 25, 75, or...

  14. 21 CFR 520.390b - Chloramphenicol capsules.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Chloramphenicol capsules. 520.390b Section 520... capsules. (a) Specifications. Each capsule contains 50, 100, 250, or 500 milligrams (mg) chloramphenicol... section. (1) Nos. 000069 and 050057 for capsules containing 50, 100, 250, or 500 mg chloramphenicol. (2...

  15. 21 CFR 520.2605 - Trimeprazine tartrate and prednisolone capsules.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Trimeprazine tartrate and prednisolone capsules... Trimeprazine tartrate and prednisolone capsules. (a) Specifications. Each capsule contains 3.75 milligrams of trimeprazine in sustained released form (as the tartrate) and 1 milligram of prednisolone (capsule no. 1) or 7...

  16. 21 CFR 520.2345a - Tetracycline hydrochloride capsules.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Tetracycline hydrochloride capsules. 520.2345a... Tetracycline hydrochloride capsules. (a) Specifications. Each capsule contains 50, 100, 125, 250, or 500... as in paragraph (c) of this section: (1) No. 000009: 250 mg per capsule. (2) No. 000069: 125, 250, or...

  17. Required Be Capsule Strength For Room Temperature Transport

    Energy Technology Data Exchange (ETDEWEB)

    Cook, B

    2005-03-21

    The purpose of this memo is to lay out the criteria for the Be capsule strength necessary for room temperature transport. Ultimately we will test full thickness capsules by sealing high pressures inside, but currently we are limited to both thinner capsules and alternative measures of capsule material strength.

  18. The Joint Cruise Missiles Project: An Acquisition History--Appendixes

    Science.gov (United States)

    1982-08-01

    21 TERCOM and Terrain Following Operation.......................22 DMA/JCMPO Organizational Interactions...50 MRASM (AGM-1091) Test Program................................52 Cruise Missile TERCOM and Survivability Flight Tests...data package TEL Transporter erector launcher T&E Test and evaluation TEMP Test and evaluation master plan TERCOM Terrain contour matching UFC Unit

  19. CMC occasional papers : a missile stability regime for South Asia.

    Energy Technology Data Exchange (ETDEWEB)

    Khan, Feroz Hassan (Pakistan Army, Islamabad, Pakistan); Vannoni, Michael Geoffrey; Rajen, Gaurav (Gaia Research Consulting, Albuquerque, NM)

    2004-06-01

    India and Pakistan have created sizeable ballistic missile forces and are continuing to develop and enlarge them. These forces can be both stabilizing (e.g., providing a survivable force for deterrence) and destabilizing (e.g., creating strategic asymmetries). Missile forces will be a factor in bilateral relations for the foreseeable future, so restraint is necessary to curtail their destabilizing effects. Such restraint, however, must develop within an atmosphere of low trust. This report presents a set of political and operational options, both unilateral and bilateral, that decreases tensions, helps rebuild the bilateral relationship, and prepares the ground for future steps in structural arms control. Significant steps, which build on precedents and do not require extensive cooperation, are possible despite strained relations. The approach is made up of three distinct phases: (1) tension reduction measures, (2) confidence building measures, and (3) arms control agreements. The goal of the first phase is to initiate unilateral steps that are substantive and decrease tensions, establish missiles as a security topic for bilateral discussion, and set precedents for limited bilateral cooperation. The second phase would build confidence by expanding current bilateral security agreements, formalizing bilateral understandings, and beginning discussion of monitoring procedures. The third phase could include bilateral agreements limiting some characteristics of national missile forces including the cooperative incorporation of monitoring and verification.

  20. Joint Air-to-Surface Standoff Missile (JASSM)

    Science.gov (United States)

    2015-12-01

    Defense Program ICE - Independent Cost Estimate IOC - Initial Operational Capability Inc - Increment JROC - Joint Requirements Oversight Council $K...penetrating warhead with a robust blast fragmentation capability. The missiles employ an IIR seeker system to attack fixed, point targets requiring precision

  1. 22 CFR 121.16 - Missile Technology Control Regime Annex.

    Science.gov (United States)

    2010-04-01

    ... missile systems, see § 121.1, Cat. VIII (a), target drones and reconnaissance drones (see § 121.1, Cat... (see § 121.1, Cat. IV(h)); (b) Reentry vehicles (see § 121.1, Cat. IV(g)), and equipment designed or modified therefor, as follows, except as provided in Note (1) below for those designed for...

  2. Health Management and Service Life for Air Force Missiles

    Science.gov (United States)

    2011-09-26

    prediction of performance will be conducted DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. PA# TBD 24 • Empiricism ...Strategic Missile A&S Approach Overview Empiricism DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. PA# TBD...Extrapolation Simulated Data 25 • Empiricism cannot always predict future state • Mechanistic method enables enhanced predictions • Mechanistic will not be

  3. Controlling The Spread of Land-Attack Cruise Missiles.

    Science.gov (United States)

    2007-11-02

    Debate in the ’New’ European Community," Arms Control Today 23, no. 2 (March 1993): 12. 38 Controlling the Spread of Land-Attack Cruise Missiles...of temperature, pressures or atmosphere in autoclaves or hydro- claves when used for the production of composites or partially processed composites

  4. A robust approach to the missile defence location problem

    NARCIS (Netherlands)

    Bloemen, A.A.F.; Evers, L.; Barros, A.I.; Monsuur, H.; Wagelmans, A.P.M.

    2011-01-01

    This paper proposes a model for determining a robust defence strategy against ballistic missile threat. Our approach takes into account a variety of possible future scenarios and different forms of robustness criteria, including the well-known absolute robustness criterion. We consider two problem

  5. White Sands Missile Range 2011 Drinking Water Quality Report

    Science.gov (United States)

    2012-01-01

    acerca de su agua potable . Haga que alguien lo traduzca para usted, o hable con alguien que lo entienda. Main Post White Sands Missile Range 2011...standards. What is This Water Quality Report? Este informe contiene informacion importante acerca de su agua potable . Haga que alguien lo traduzca

  6. Shipborne Laser Beam Weapon System for Defence against Cruise Missiles

    Directory of Open Access Journals (Sweden)

    J.P. Dudeja

    2000-04-01

    Full Text Available Sea-skim~ing cruise missiles pose the greatest threat to a surface ship in the present-day war scenario. The convenitional close-in-weapon-systems (CIWSs are becoming less reliable against these new challenges requiring extremely fast reaction time. Naval Forces see a high energy laser as a feasible andjeffective directed energy weapon against sea-skimming antiship cruise missiles becauseof its .ability to deliver destructive energy at the speed of light on to a distant target. The paper comparesthe technology and capability of deuterium fluoride (DF and chemical-oxygen-iodine laser (COIL in effectively performing the role of a shipborne CIWS altainst sea-skimming missiles. Out of these twolasers, it is argued that DF laser wo.uld be more effective a,s a shipborne weapon for defence against sea-skimmin,g cruise missiles. Besides the high energy laser as the primary (killing laser, othersub-systems required in the complete weapon system would be: A beacon laser to sense phase distor'ions in the primary laser, adaptive optics to compensate the atmospheric distortions, beam-directing optics, illuminating lasers, IRST sensors, surveillance and tracking radars, interfacing system, etc.

  7. A Prototype Fibre Optic Gyroscope for Missile Guidance Applications,

    Science.gov (United States)

    This paper describes the design of a prototype fibre optic gyro, which is intended for missile guidance applications. Important design constraints...beam-splitter. Serrodyne phase ramps are impressed on the light propagating round the fibre optic sensor coil connected to the integrated optics chip

  8. Capsule Endoscopy: New Technology, Old Complication ...

    African Journals Online (AJOL)

    Capsule Endoscopy: New Technology, Old Complication. ... A 65-year-old female with a long standing history of anemia and obscure gastrointestinal ... The patient was resuscitated and taken up for an explorative laparotomy where a short ...

  9. Therapeutic Capsule Endoscopy: Opportunities and Challenges

    Directory of Open Access Journals (Sweden)

    Mahdi Rasouli

    2011-01-01

    Full Text Available The increasing demand for non-invasive (or less-invasive monitoring and treatment of medical conditions has attracted both physicians and engineers to work together and investigate new methodologies. Wireless capsule endoscopy is a successful example of such techniques which has become an accepted routine for diagnostic inspection of the gastrointestinal tract. This method offers a non-invasive alternative to traditional endoscopy and provides the opportunity for exploring distal areas of the small intestine which are otherwise not accessible. Despite these advantages, wireless capsule endoscopy is still limited in functionality compared to traditional endoscopy. Wireless capsule endoscopes with advanced functionalities, such as biopsy or drug delivery, are highly desirable. In this article, the current status of wireless capsule endoscopy is reviewed together with some of its possible therapeutic applications as well as the existing challenges.

  10. Hardware in Loop Simulation for Missile Guidance and Control Systems

    Directory of Open Access Journals (Sweden)

    S. K. Chaudhuri

    1997-07-01

    Full Text Available The purpose of the guidance law is to determine appropriate missile flight path dynamics to achieve mission objective in an efficient manner based on navigation information. Today, guided missiles which are aerodynamically unstable or non-linear in all or part of the flight envelopes need control systems for stability as well as for steering. Many classical guidance and control laws have been used for tactical missiles with varying degrees of performance, complexity and seeker/sensor requirements. Increased accuracy requirements and more dynamic tactics of modern warfare demand improvement of performance which is a trade-off between sophisticated hardware and more sophisticated software. To avoid increase in cost by hardware sophistication, today's trend is to exploit new theoretical methods and low cost high speed microprocessor techniques. Missile test flights are very expensive. The missile system with its sophisticated software and hardware is not reusable after a test launch. Hardware-in-loop Simulation (HILS facilities and methodology form a well integrated system aimed at transforming a preliminary guidance and control system design to flight software and hardware with trajectory right from lift-off till its impact. Various guidance and control law studies pertaining to gathering basket and stability margins, pre-flight, post-flight analyses and validation of support systems have been carried out using this methodology. Nearly full spectrum of dynamically accurate six-degrees-of-freedom (6-DOF model of missile systems has been realised in the HILS scenario. The HILS facility allows interconnection of missile hardware in flight configuration. Pre-flight HILS results have matched fairly well with actual flight trial results. It was possible to detect many hidden defects in the onboard guidance and control software as well as in hardware during HILS. Deficiencies in model, like tail-wag-dog (TWD, flexibility, seeker dynamics and defects in

  11. Systematic Design of edical Capsule Robots

    OpenAIRE

    Beccani, M; Tunc, H; Taddese, AZ; Susilo, E; Volgiesi, P; Ledeczi, A; Valdastri, P

    2015-01-01

    Medical capsule robots that navigate inside the body as diagnostic and interventional tools are an emerging and challenging research area within medical CPSs. These robots must provide locomotion, sensing, actuation, and communication within severe size, power, and computational constraints. This paper presents the first effort for an open architecture, platform design, software infrastructure, and a supporting modular design environment for medical capsule robots to further this research area.

  12. Dynamics of nonspherical compound capsules in simple shear flow

    Science.gov (United States)

    Luo, Zheng Yuan; Bai, Bo Feng

    2016-10-01

    The dynamics of an initially ellipsoidal compound capsule in a simple shear flow is investigated numerically using a three-dimensional front-tracking finite-difference model. Membrane bending resistance is included based on Helfrich's energy function besides the resistances against shear deformation and area dilatation governed by the constitutive law of Skalak et al. In this paper, we focus specifically on how the presence of a spherical inner capsule and its size affects the characteristics and transition of various dynamical states of nonspherical compound capsules (i.e., the outer capsule). Significant differences in the dynamical characteristics are observed between compound capsules and homogeneous capsules in both qualitative and quantitative terms. We find the transition from swinging to tumbling can occur at vanishing viscosity mismatch through increasing the inner capsule size alone to a critical value regardless of the initial shape of the nonspherical compound capsule (i.e., prolate or oblate). Besides, for compound capsules with viscosity mismatch, the critical viscosity ratio for the swinging-to-tumbling transition remarkably decreases by increasing the inner capsule size. It is thus concluded that the inner capsule size is a key governing parameter of compound capsule dynamics apart from the capillary number, aspect ratio, and viscosity ratio that have been long identified for homogeneous capsules. Further, we discuss the mechanisms underlying the effects of the inner capsule on the compound capsule dynamics from the viewpoint of the effective viscosity of internal fluid and find that the effects of the inner capsule on compound capsule dynamics are qualitatively similar to that of increasing the internal viscosity on homogeneous capsule dynamics. However, in quantitative terms, the compound capsule cannot be viewed as a homogeneous capsule with higher viscosity as obvious inhomogeneity in fluid stress distribution is induced by the inner membrane.

  13. Joint Counterair and Theater Missile Defense Doctrine to Defend against Unmanned Aerial Vehicles and Cruise Missiles in Asymmetric Warfare

    Science.gov (United States)

    2009-02-12

    state lasers, and a megawatt-class Chemical Oxygen Iodine Laser (COIL) to detect, track, target, and destroy ballistic missiles shortly after launch... disproportionate cost tradeoff between threat weapon systems and the proposed interceptors. With a price tag of over $1M per interceptor such as Patriot

  14. Capsule endoscopy in neoplastic diseases

    Institute of Scientific and Technical Information of China (English)

    Marco Pennazio; Emanuele Rondonotti; Roberto de Franchis

    2008-01-01

    Until recently,diagnosis and management of small-bowel tumors were delayed by the difficulty of access to the small bowel and the poor diagnostic capabilities of the available diagnostic techniques.An array of new methods has recently been developed,increasing the possibility of detecting these tumors at an earlier stage.Capsule endoscopy (CE) appears to be an ideal tool to recognize the presence of neoplastic lesions along this organ,since it is non-invasive and enables the entire small bowel to be visualized.Highquality images of the small-bowel mucosa may be captured and small and fiat lesions recognized,without exposure to radiation.Recent studies on a large population of patients undergoing CE have reported small-bowel tumor frequency only slightly above that reported in previous surgical series (range,1.6%-2.4%)and have also confirmed that the main clinical indication to CE in patients with small-bowel tumors is obscure gastrointestinal (GI) bleeding.The majority of tumors identified by CE are malignant;many were unsuspected and not found by other methods.However,it remains difficult to identify pathology and tumor type based on the lesion's endoscopic appearance.Despite its limitations,CE provides crucial information leading in most cases to changes in subsequent patient management.Whether the use of CE in combination with other new diagnostic (MRI or multidetector CT enterography) and therapeutic (Push-and-pull enteroscopy) techniques will lead to earlier diagnosis and treatment of these neoplasms,ultimately resulting in a survival advantage and in cost savings,remains to be determined through carefully-designed studies.

  15. 3D Printed Programmable Release Capsules.

    Science.gov (United States)

    Gupta, Maneesh K; Meng, Fanben; Johnson, Blake N; Kong, Yong Lin; Tian, Limei; Yeh, Yao-Wen; Masters, Nina; Singamaneni, Srikanth; McAlpine, Michael C

    2015-08-12

    The development of methods for achieving precise spatiotemporal control over chemical and biomolecular gradients could enable significant advances in areas such as synthetic tissue engineering, biotic-abiotic interfaces, and bionanotechnology. Living organisms guide tissue development through highly orchestrated gradients of biomolecules that direct cell growth, migration, and differentiation. While numerous methods have been developed to manipulate and implement biomolecular gradients, integrating gradients into multiplexed, three-dimensional (3D) matrices remains a critical challenge. Here we present a method to 3D print stimuli-responsive core/shell capsules for programmable release of multiplexed gradients within hydrogel matrices. These capsules are composed of an aqueous core, which can be formulated to maintain the activity of payload biomolecules, and a poly(lactic-co-glycolic) acid (PLGA, an FDA approved polymer) shell. Importantly, the shell can be loaded with plasmonic gold nanorods (AuNRs), which permits selective rupturing of the capsule when irradiated with a laser wavelength specifically determined by the lengths of the nanorods. This precise control over space, time, and selectivity allows for the ability to pattern 2D and 3D multiplexed arrays of enzyme-loaded capsules along with tunable laser-triggered rupture and release of active enzymes into a hydrogel ambient. The advantages of this 3D printing-based method include (1) highly monodisperse capsules, (2) efficient encapsulation of biomolecular payloads, (3) precise spatial patterning of capsule arrays, (4) "on the fly" programmable reconfiguration of gradients, and (5) versatility for incorporation in hierarchical architectures. Indeed, 3D printing of programmable release capsules may represent a powerful new tool to enable spatiotemporal control over biomolecular gradients.

  16. Scaling effects in spiral capsule robots.

    Science.gov (United States)

    Liang, Liang; Hu, Rong; Chen, Bai; Tang, Yong; Xu, Yan

    2017-04-01

    Spiral capsule robots can be applied to human gastrointestinal tracts and blood vessels. Because of significant variations in the sizes of the inner diameters of the intestines as well as blood vessels, this research has been unable to meet the requirements for medical applications. By applying the fluid dynamic equations, using the computational fluid dynamics method, to a robot axial length ranging from 10(-5) to 10(-2) m, the operational performance indicators (axial driving force, load torque, and maximum fluid pressure on the pipe wall) of the spiral capsule robot and the fluid turbulent intensity around the robot spiral surfaces was numerically calculated in a straight rigid pipe filled with fluid. The reasonableness and validity of the calculation method adopted in this study were verified by the consistency of the calculated values by the computational fluid dynamics method and the experimental values from a relevant literature. The results show that the greater the fluid turbulent intensity, the greater the impact of the fluid turbulence on the driving performance of the spiral capsule robot and the higher the energy consumption of the robot. For the same level of size of the robot, the axial driving force, the load torque, and the maximum fluid pressure on the pipe wall of the outer spiral robot were larger than those of the inner spiral robot. For different requirements of the operating environment, we can choose a certain kind of spiral capsule robot. This study provides a theoretical foundation for spiral capsule robots.

  17. Lubricin in human breast tissue expander capsules.

    Science.gov (United States)

    Cheriyan, Thomas; Guo, Lifei; Orgill, Dennis P; Padera, Robert F; Schmid, Thomas M; Spector, Myron

    2012-10-01

    Capsular contraction is the most common complication of breast reconstruction surgery. While presence of the contractile protein alpha smooth muscle actin (α-SMA) is considered among the causes of capsular contraction, the exact etiology and pathophysiology is not fully understood. The objective of this study was to investigate the possible role of lubricin in capsular formation and contraction by determining the presence and distribution of the lubricating protein lubricin in human breast tissue expander capsules. Related aims were to evaluate select histopathologic features of the capsules, and the percentage of cells expressing α-SMA, which reflects the myofibroblast phenotype. Capsules from tissue expanders were obtained from eight patients. Lubricin, at the tissue-implant interface, in the extracellular matrix, and in cells, and α-SMA-containing cells were evaluated immunohistochemically. The notable finding was that lubricin was identified in all tissue expander capsules: as a discrete layer at the tissue-implant interface, extracellular, and intracellular. There was a greater amount of lubricin in the extracellular matrix in the intimal-subintimal zone when compared with the tissue away from the implant. Varying degrees of synovial metaplasia were seen at the tissue-implant interface. α-SMA-containing cells were also seen in all but one patient. The findings might help us better understand factors involved in capsule formation.

  18. Flight testing of the AIM/RIM-7M missile, preflight analysis

    Science.gov (United States)

    Hicks, W.; Greenberg, E.

    1981-11-01

    The AIM/RIM-7M missile is the most recent version of the AIM-7 missile series. It is in the preproduction phase and has completed most of the preproduction flight test evaluation. A description is presented of the preflight simulation techniques used, taking into account the value of the techniques in predicting the results of actual flights. The AIM/RIM-7M is a semiactive, radar-guided homing missile with sophisticated onboard digital processing. It may be launched from either an aircraft or a surface system. To a large degree, the AIM/RIM-7M represents problems typical of all guided missiles. The described techniques are directly applicable to radar-guided missiles and generically to all types of guided missiles. Attention is given to simulation bay activities, the anechoic chamber, aspects of RF control, the target array, computer models, aspects of preflight simulations, and the test setup.

  19. The proliferation of aerospace weapons technology: Ballistic missiles and the case of Brazil

    Science.gov (United States)

    Vossen, Terrence John

    1993-04-01

    The rationale behind the development of ballistic missile production in Brazil is examined by exploring the political, military, and economic determinants of ballistic missile demand in that country. To ascertain how Brazil developed missile production capabilities, the contributions of aerospace industries in industrialized states, the Brazilian space program, trade between less-developed countries, and illicit trade in missile technology are assessed. It is argued that missile development increasingly became a function of economic as opposed to security considerations, and that technologies transferred from developed country aerospace firms and Brazil's space program were primarily responsible for the creation of production capabilities. It is also contended that the proliferation of missile technology to Brazil was consistent with the workings of a system evident in the aerospace weapons technology market that sustains the horizontal spread of weapons production capabilities.

  20. Computer simulation of absolute and contrast infrared signatures from missile noses

    Science.gov (United States)

    Tofani, Alessandro

    1992-03-01

    A computer simulation was performed to obtain an estimate of the infrared radiant intensity and radiative contrast produced by missile noses. The temperature distribution on the nose was computed by taking into account the effects of aerodynamic and solar heating, sky irradiance, and radiative cooling. The corresponding absolute and contrast signatures were obtained by considering the influence of both atmosphere and target geometry, for six target classes, including cruise missiles, tactical ballistic missiles, and air-to-air and surface-to-surface missiles. Both radiant intensity and radiative contrast were computed as a function of missile altitude or missile distance for all targets. A comparison of radiative quantities in the 3- to 5-micron and 8- to 12-micron bands shows that usually the spectral region that gives the strongest signal is not the one that gives the highest contrast.

  1. Application of Pontryagin’s Minimum Principle in Optimum Time of Missile Manoeuvring

    Directory of Open Access Journals (Sweden)

    Sari Cahyaningtias

    2016-11-01

    Full Text Available Missile is a guided weapon and designed to protect outermost island from a thread of other country. It, commonly, is used as self defense. This research presented surface-to-surface missile in final dive manoeuvre for fixed target. Furthermore, it was proposed manoeuvring based on unmanned aerial vehicle (UAV, autopilot system, which needs accuration and minimum both time and thrust of missile while attacking object. This paper introduced pontryagin’s Minimum Principle, which is useable to solve the problem. The numerical solution showed that trajectory of the missile is split it up in three sub-intervals; flight, climbing, and diving. The numerical simulation showed that the missile must climb in order to satisfy the final dive condition and the optimum time of a missile depend on initial condition of the altitude and the terminal velocity

  2. Assessment of Containment Structures Against Missile Impact Threats

    Institute of Scientific and Technical Information of China (English)

    LI Q M

    2006-01-01

    In order to ensure the highest safety requirements,nuclear power plant structures (the containment structures,the fuel storages and transportation systems) should be assessed against all possible internal and external impact threats.The internal impact threats include kinetic missiles generated by the failure of high pressure vessels and pipes,the failure of high speed rotating machineries and accidental drops.The external impact threats may come from airborne missiles,aircraft impact,explosion blast and fragments.The impact effects of these threats on concrete and steel structures in a nuclear power plant are discussed.Methods and procedures for the impact assessment of nuclear power plants are introduced.Recent studies on penetration and perforation mechanics as well as progresses on dynamic properties of concrete-like materials are presented to increase the understanding of the impact effects on concrete containment structures.

  3. BTT autopilot design for agile missiles with aerodynamic uncer tainty

    Institute of Scientific and Technical Information of China (English)

    Yueyue Ma; Jie Guo; Shengjing Tang

    2015-01-01

    The approach to the synthesis of autopilot with aerody-namic uncertainty is investigated in order to achieve large maneu-verability of agile missiles. The dynamics of the agile missile with reaction-jet control system (RCS) are presented. Subsequently, the cascade control scheme based on the bank-to-turn (BTT) steering technique is described. To address the aerodynamic un-certainties encountered by the control system, the active distur-bance rejection control (ADRC) method is introduced in the autopi-lot design. Furthermore, a compound control er, using extended state observer (ESO) to online estimate system uncertainties and calculate derivative of command signals, is designed based on dynamic surface control (DSC). Nonlinear simulation results show the feasibility of the proposed approach and validate the robust-ness of the control er with severe unmodeled dynamics.

  4. Potential applications of video disc technology to missile guidance

    Science.gov (United States)

    Ormsby, C. C.; Long, H. S.

    1980-01-01

    An assessment of video disk data storage technology suggests the possibility of a missile-borne data storage system providing real-time access to a data base consisting of approximately 10 to the 11th bits, with readout rates of up to 200 Mbits/sec and average frame access time of 2-3 sec. The Direct Read After Write (DRAW) technology currently under development will also provide a data recording capability of 10 to the 7th - 10 to the 8th bits/sec. Five cruise missile applications of this technology are discussed: (1) Terrain Contour Matching (TERCOM) data base guidance; (2) target signature data base guidance; (3) terrain/obstacle files navigation; (4) preprogrammed route storage navigation; and (5) reconnaissance data recording.

  5. Design and development of Propulsion System for Antitank Guided Missile

    Directory of Open Access Journals (Sweden)

    T. Mohan Reddy

    1995-07-01

    Full Text Available A Propulsion system is designed and developed for the third generation antitank guided missile (ATGM. It consists of a separate booster and sustainer. Booster is ahead of sustainer, having four nozzles canted to the missile axis. Sustainer discharges through a supersonic blast tube. Low smoke, high energy nitramine propellant for this propulsion system developed by the High Energy Materials Research Laboratory (HEMRL, Pune, has been successfully flight-tested. The booster grain is tube-in-tube configuration with end inhibition and the sustainer grain is of end burning configuration. High strength aluminium alloy, HE-15, is used for rocket motor components. Glass-phenolic composite ablative material is used for thermal protection of motors and high density graphite is used for nozzle throats. The design considerations and approach, including grain configuration, nozzle, and ignitersare briefly discussed. The propulsion system has been extensively tested in static tests and in flights, establishing the satisfactory performance of the system.

  6. A Predictive Explicit Guidance Scheme for Ballistic Missiles

    Directory of Open Access Journals (Sweden)

    N. Prabhakar

    2013-09-01

    Full Text Available A new approach to the design of ballistic missile guidance is presented in this paper. The proposed method uses the missile model to predict the likely impact point at every guidance cycle and apply course corrections based on the predicted impact point (PIP deviations. The algorithm also estimates the in-flight thrust variation from nominal and accordingly updates the model to reduce the uncertainty in the prediction of the impact point. The performance of the algorithm is tested through 6-DOF simulation. The simulation results show excellent performance of the proposed guidance scheme in nominal & off nominal cases.Defence Science Journal, 2013, 63(5, pp.456-461, DOI:http://dx.doi.org/10.14429/dsj.63.2575

  7. Discrete Sliding Mode Control for Hypersonic Cruise Missile

    Directory of Open Access Journals (Sweden)

    Yong Hua Fan

    2016-01-01

    Full Text Available A discrete variable structure control (DVSC with sliding vector is presented to track the velocity and acceleration command for a hypersonic cruise missile. In the design an integrator is augmented to ensure the tracking with zero steady-state errors. Furthermore the sliding surface of acceleration is designed using the error of acceleration and acceleration rate to avoid the singularity of control matrix. A proper power rate reaching law is utilized in this proposal; therefore the state trajectory from any initial point can be driven into the sliding surface. Besides, in order to validate the robustness of controller, the unmolded dynamic and parameter disturbance of the missile are considered. Through simulation the proposed controller demonstrates good performance in tracking velocity and acceleration command.

  8. External Peer Review Report on the Missile Defense Agency Office of Internal Review

    Science.gov (United States)

    2015-05-14

    No. DODIG-2015-123 M A Y 1 4 , 2 0 1 5 External Peer Review Report on the Missile Defense Agency Office of Internal Review Report Documentation...3. DATES COVERED 00-00-2015 to 00-00-2015 4. TITLE AND SUBTITLE External Peer Review Report on the Missile Defense Agency Office of Internal... REVIEW SUBJECT: External Peer Review Report on the Missile Defense Agency Office of Internal Review (Report No. DODIG-2015-123) Attached is the

  9. Sea-Based Ballistic Missile Defense - Background and Issues for Congress

    Science.gov (United States)

    2009-12-22

    Aegis ships. The program involved modifying the SM-2 Block IV air-defense missile. The missile, as modified, was called the Block IVA version. The...system was designed to intercept descending missiles endo-atmospherically (i.e., within the atmosphere) and destroy them with the Block IVA missile’s...the SBX radar in Texas.52 SBX underwent sea trials and high- power radiation testing in the Gulf of Mexico in 2005. It was then moved by a heavy

  10. ARMS CONTROL: U.S. Efforts to Control the Transfer of Nuclear-Capable Missile Technology

    Science.gov (United States)

    2015-12-11

    risk of diversion is an important part of its analysis, Commerce focuses its reviews on certain countries that are developing nuclear-capable missiles...ogy to countries developing nuclear-capable missile systems. Our work was conducted in the United States at the Departments of State, Commerce , and...the MTCR in halting the transfer of MTCR-related systems and technology to countries developing nuclear-capable missile systems. The objectives, scope

  11. HOMA: Israel’s National Missile Defense Strategy (Abridged Version)

    Science.gov (United States)

    2007-11-02

    developed by Tadiran Electronics Systems), and the Hazelnut Tree launcher control center.28 Each battery is designed to track and counter —14 enemy...Communications center, (4) HAZELNUT TREE fire control center, (5) GREEN PINE radar antenna, (6) Radar control center, (7) Radar power unit, (8) Radar...cooling unit. A battery has four launch vehicles with six ready missiles each, a Tadiran Citron Tree launch control centre, a Hazelnut Tree fire

  12. Long-Range Ballistic Missile Defense in Europe

    Science.gov (United States)

    2010-04-26

    and another transportable radar to be deployed in a country closer to Iran (which was never publicly identified). Deployment of the GMD European...former Polish President Lech Walesa and former Czech Prime Minister Mirek Topolanek criticized the Obama administration’s policy toward the region.4...the Pacific missile test range, would have been refurbished and transported to a fixed site at a military training base in the Czech Republic. The

  13. System Architecture for Anti-Ship Ballistic Missile Defense (ASBMD)

    OpenAIRE

    Hobgood, Jean; Madison, Kimberly; Pawlowski, Geoffrey; Nedd, Steven.; Roberts, Michael; Rumberg, Paige

    2009-01-01

    Approved for public release; distribution is unlimited. Recent studies suggest that China is developing a new class of ballistic missiles that can be used against moving targets, such as ships. One such technology is anticipated to cover a range of 2,000 kilometers and operate at a speed of Mach 10. The threat is also capable of maneuvering both during the midcourse and terminal flight phases for the purposes of guidance, target acquisition, and countermeasures. This threat could greatl...

  14. Missile trajectory shaping using sampling-based path planning

    OpenAIRE

    Pharpatara, Pawit; Pepy, Romain; Hérissé, Bruno; Bestaoui, Yasmina

    2013-01-01

    International audience; This paper presents missile guidance as a complex robotic problem: a hybrid non-linear system moving in a heterogeneous environment. The proposed solution to this problem combines a sampling-based path planner, Dubins' curves and a locally-optimal guidance law. This algorithm aims to find feasible trajectories that anticipate future flight conditions, especially the loss of manoeuverability at high altitude. Simulated results demonstrate the substantial performance imp...

  15. 1997 Report to the Congress on Ballistic Missile Defense.

    Science.gov (United States)

    2007-11-02

    be modified to the Block IVA TBMD configuration. This area defense program will provide a lower-tier or endoatmospheric intercept capability. The...and ADCP completed operational testing and evaluation at White Sands Missile Range, New Mexico . A successful TMD demonstration was conducted as part of...UOES FY 99) Sea Lower PAC-3 Configuration Three (FUE FY 99) Navy Theater Wide TBMD AEGIS With SM-2 Block IVA (FUE FY 02; UOES Software

  16. The U.S. Navy and the Cuban Missile Crisis

    Science.gov (United States)

    1990-05-22

    floor of 1,200 feet, the Guidelines were photographed at Bahia Honda, Havana, La Coloma, Mariel, Matanzas , San Julian, and Cienfuegos. Photography of the...a sharp warning might deter the Soviets from deploying ballistic missiles to Cuba, but unwilling to go public with the evidence 68 available to date...p. 4; "United States Air Force Security Service: Performance During the Cuban Crisis, April- December 1962," n.d., NSACF, pp. 12, 68 ; "Air Force

  17. Space and Missile Systems Center Standard: Space Flight Pressurized Systems

    Science.gov (United States)

    2015-02-28

    pressure and vehicle structural loads. The main propellant tank of a launch vehicle is a typical example. Pressurized System: A system that...SPACE AND MISSILE SYSTEMS CENTER STANDARD SPACE FLIGHT PRESSURIZED SYSTEMS APPROVED FOR PUBLIC RELEASE...Space Flight Pressurized Systems 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER

  18. Open Architecture as an Enabler for FORCEnet Cruise Missile Defense

    Science.gov (United States)

    2007-09-01

    battlespace via the FORCEnet information network. Current capability gaps include a lack of common configuration and Fire Control Quality ( FCQ ...connectivity among platforms that is needed to achieve and maintain a robust cruise missile defense. FCQ is defined as data obtained with the sufficient...platform, or a combination of the two. With Fire Control Quality ( FCQ ) threat data from a remote sensor, the remote unit can initiate a launch

  19. Analyzing and designing object-oriented missile simulations with concurrency

    Science.gov (United States)

    Randorf, Jeffrey Allen

    2000-11-01

    A software object model for the six degree-of-freedom missile modeling domain is presented. As a precursor, a domain analysis of the missile modeling domain was started, based on the Feature-Oriented Domain Analysis (FODA) technique described by the Software Engineering Institute (SEI). It was subsequently determined the FODA methodology is functionally equivalent to the Object Modeling Technique. The analysis used legacy software documentation and code from the ENDOSIM, KDEC, and TFrames 6-DOF modeling tools, including other technical literature. The SEI Object Connection Architecture (OCA) was the template for designing the object model. Three variants of the OCA were considered---a reference structure, a recursive structure, and a reference structure with augmentation for flight vehicle modeling. The reference OCA design option was chosen for maintaining simplicity while not compromising the expressive power of the OMT model. The missile architecture was then analyzed for potential areas of concurrent computing. It was shown how protected objects could be used for data passing between OCA object managers, allowing concurrent access without changing the OCA reference design intent or structure. The implementation language was the 1995 release of Ada. OCA software components were shown how to be expressed as Ada child packages. While acceleration of several low level and other high operations level are possible on proper hardware, there was a 33% degradation of 4th order Runge-Kutta integrator performance of two simultaneous ordinary differential equations using Ada tasking on a single processor machine. The Defense Department's High Level Architecture was introduced and explained in context with the OCA. It was shown the HLA and OCA were not mutually exclusive architectures, but complimentary. HLA was shown as an interoperability solution, with the OCA as an architectural vehicle for software reuse. Further directions for implementing a 6-DOF missile modeling

  20. Joint Air-to-Surface Standoff Missile (JASSM)

    Science.gov (United States)

    2013-12-01

    Retrieval Dev Est - Development Estimate DoD - Department of Defense DSN - Defense Switched Network Econ - Economic Eng - Engineering Est...Missile Reliability (KSA) (CPD para 6.2.8) 4th Lot .91 4th Lot. 91 IOT &E .80 4th Lot .85 IOT &E .95 4th Lot .91 JASSM December 2013 SAR April 16, 2014 17...Acronyms and Abbreviations CPD - Capability Production Document IOT &E - Initial Operational Test and Evaluation KPP - Key Performance Parameter KSA - Key

  1. Quadrennial Defense Review and Ballistic Missile Defense Review

    Science.gov (United States)

    2010-03-11

    global defense posture 3 BMDR Highlights • Outlines a strategy and policy framework to – Defend the homeland against limited ballistic missile attack...abroad – Collaborate closely with allies and partners – Pursue a cooperative and tailored global defense posture – Strengthen US civilian capacity...reviews in 2010 – QDR and BMDR released February 1, 2010 – Nuclear Posture Review to be released this spring – Space Posture Review, with Director of

  2. Decoupling Control Method Based on Neural Network for Missiles

    Institute of Scientific and Technical Information of China (English)

    ZHAN Li; LUO Xi-shuang; ZHANG Tian-qiao

    2005-01-01

    In order to make the static state feedback nonlinear decoupling control law for a kind of missile to be easy for implementation in practice, an improvement is discussed. The improvement method is to introduce a BP neural network to approximate the decoupling control laws which are designed for different aerodynamic characteristic points, so a new decoupling control law based on BP neural network is produced after the network training. The simulation results on an example illustrate the approach obtained feasible and effective.

  3. Intestinal preparation prior to capsule endoscopy administration

    Institute of Scientific and Technical Information of China (English)

    Vicente Pons Beltrán; Cristina Carretero; Bego(n)a Gonzalez-Suárez; I(n)aqui Fernández-Urien; Miguel Mu(n)oz Navas

    2008-01-01

    In order to have an adequate view of the whole small intestine during capsule endoscopy,the preparation recommended consists of a clear liquid diet and an overnight fast.However,visualization of the small bowel during video capsule endoscopy can be impaired by intestinal contents.To improve mucosal visualization,some authors have evaluated different regimens of preparation.There is no consensus about the necessity of intestinal preparation for capsule endoscopy and it should be interesting to develop adequate guidelines to improve its efficacy and tolerability.Moreover,the effect of preparation type (purgative) on intestinal transit time is not clear.Since a bowel preparation cannot definitively improve its visibility (and theoretically the yield of the test),it is not routinely recommended.

  4. Spectral measurements of asymmetrically irradiated capsule backlighters

    Science.gov (United States)

    Keiter, P. A.; Drake, R. P.

    2016-11-01

    Capsule backlighters provide a quasi-continuum x-ray spectrum over a wide range of photon energies [J. F. Hansen et al., Rev. Sci. Instrum. 79, 013504 (2008)]. Ideally one irradiates the capsule backlighter symmetrically, however, in complex experimental geometries, this is not always possible. In recent experiments we irradiated capsule backlighters asymmetrically and measured the x-ray spectrum from multiple directions. We will present time-integrated spectra over the photon energy range of 2-13 keV and time-resolved spectra over the photon energy range of 2-3 keV. We will compare the spectra from different lines of sight to determine if the laser asymmetry results in an angular dependence in the x-ray emission.

  5. Unsteady Pressures on a Generic Capsule Shape

    Science.gov (United States)

    Burnside, Nathan; Ross, James C.

    2015-01-01

    While developing the aerodynamic database for the Orion spacecraft, the low-speed flight regime (transonic and below) proved to be the most difficult to predict and measure accurately. The flow over the capsule heat shield in descent flight was particularly troublesome for both computational and experimental efforts due to its unsteady nature and uncertainty about the boundary layer state. The data described here were acquired as part of a study to improve the understanding of the overall flow around a generic capsule. The unsteady pressure measurements acquired on a generic capsule shape are presented along with a discussion about the effects of various flight conditions and heat-shield surface roughness on the resulting pressure fluctuations.

  6. Capsule endoscopy—A mechatronics perspective

    Science.gov (United States)

    Lin, Lin; Rasouli, Mahdi; Kencana, Andy Prima; Tan, Su Lim; Wong, Kai Juan; Ho, Khek Yu; Phee, Soo Jay

    2011-03-01

    The recent advances in integrated circuit technology, wireless communication, and sensor technology have opened the door for development of miniature medical devices that can be used for enhanced monitoring and treatment of medical conditions. Wireless capsule endoscopy is one of such medical devices that has gained significant attention during the past few years. It is envisaged that future wireless capsule endoscopies replace traditional endoscopy procedures by providing advanced functionalities such as active locomotion, body fluid/tissue sampling, and drug delivery. Development of energy-efficient miniaturized actuation mechanisms is a key step toward achieving this goal. Here, we review some of the actuators that could be integrated into future wireless capsules and discuss the existing challenges.

  7. Robust Hybrid Control for Ballistic Missile Longitudinal Autopilot

    Institute of Scientific and Technical Information of China (English)

    WAEL Mohsen Ahmed; QUAN Quana

    2011-01-01

    This paper investigates the boost phase's longitudinal autopilot of a ballistic missile equipped with thrust vector control.The existing longitudinal autopilot employs time-invariant passive resistor-inductor-capacitor (RLC) network compensator as a control strategy,which does not take into account the time-varying missile dynamics.This may cause the closed-loop system instability in the presence of large disturbance and dynamics uncertainty.Therefore,the existing controller should be redesigned to achieve more stable vehicle response.In this paper,based on gain-scheduling adaptive control strategy,two different types of optimal controllers are proposed.The first controller is gain-scheduled optimal tuning-proportional-integral-derivative (PID) with actuator constraints,which supplies better response but requires a priori knowledge of the system dynamics.Moreover,the controller has oscillatory response in the presence of dynamic uncertainty.Taking this into account,gain-scheduled optimal linear quadratic (LQ) in conjunction with optimal tuning-compensator offers the greatest scope for controller improvement in the presence of dynamic uncertainty and large disturbance.The latter controller is tested through various scenarios for the validated nonlinear dynamic flight model of the real ballistic missile system with autopilot exposed to external disturbances.

  8. Changing law of launching pitching angular velocity of rotating missile

    Institute of Scientific and Technical Information of China (English)

    Liu Guang; Xu Bin; Jiao Xiaojuan; Zhen Tiesheng

    2014-01-01

    In order to provide accurate launching pitching angular velocity (LPAV) for the exterior trajectory optimization design, multi-flexible body dynamics (MFBD) technology is presented to study the changing law of LPAV of the rotating missile based on spiral guideway. An MFBD virtual prototype model of the rotating missile launching system is built using multi-body dynamics modeling technology based on the built flexible body models of key components and the special force model. The built model is verified with the frequency spectrum analysis. With the flexible body contact theory and nonlinear theory of MFBD technology, the research is conducted on the influence of a series of factors on LPAV, such as launching angle change, clearance between launching canister and missile, thrust change, thrust eccentricity and mass eccentricity, etc. Through this research, some useful values of the key design parameters which are difficult to be measured in physical tests are obtained. Finally, a simplified mathematical model of the changing law of LPAV is presented through fitting virtual test results using the linear regression method and verified by physical flight tests. The research results have important significance for the exterior trajectory optimization design.

  9. Design and Simulation of TF and TA Controller for Missile

    Institute of Scientific and Technical Information of China (English)

    ZHA Xu; GUANG Cheng-qi; CUI Ping-yuan; LIU Yong-cai

    2005-01-01

    A nonlinear terrain following(TF) and terrain avoidance(TA) controller is proposed for missile control systems.Based on classical TF algorithm (adaptive angle method), a new method for TF controller is proposed by using angle of attack. A method of obtaining terrain outline data from digital elevation map (DEM) for TF control is discussed in order to save store space. A TA algorithm is proposed by using bank-to-turn technique. The block control model, which is suitable for backstepping design, is given for nonlinear model of missile. Making full use of the characteristics of the system and combining block control principle and backstepping technique, a robust controller design method is proposed. Uncertainties in every sub-block are allowed, and can be canceled by using the idea of nonlinear damping. It is proved that the state tracking errors are converged to a neighborhood of the origin exponentially. Finally, nonlinear six-degree-of-freedom simulation results for the missile model are presented to demonstrate the effectiveness of the proposed control law.

  10. Video capsule endoscopy in inflammatory bowel disease

    Science.gov (United States)

    Collins, Paul D

    2016-01-01

    Video capsule endoscopy (VCE) has evolved to become an important tool for the non-invasive examination of the small bowel, which hitherto had been relatively inaccessible to direct visualisation. VCE has been shown to play a role in monitoring the activity of small bowel Crohn’s disease and can be used to assess the response to anti-inflammatory treatment in Crohn’s disease. For those patients with Crohn’s disease who have undergone an intestinal resection, VCE has been assessed as a tool to detect post-operative recurrence. VCE may also aid in the reclassification of patients with a diagnosis of Inflammatory Bowel Disease Unclassified to Crohn’s disease. The evolution of colon capsule endoscopy (CCE) has expanded the application of this technology further. The use of CCE to assess the activity of ulcerative colitis has been described. This advance in capsule technology has also fuelled interest in its potential role as a minimally invasive tool to assess the whole of GI tract opening the possibility of its use for the panenteric assessment of Crohn’s disease. VCE is a safe procedure. However, the risk of a retained capsule is higher in patients with suspected or confirmed Crohn’s disease compared with patients having VCE examination for other indications. A retained video capsule is rare after successful passage of a patency capsule which may be utilised to pre-screen patients undergoing VCE. This paper describes the use of VCE in the assessment of inflammatory bowel disease. PMID:27499830

  11. Study on combat effectiveness of air defense missile weapon system based on queuing theory

    Science.gov (United States)

    Zhao, Z. Q.; Hao, J. X.; Li, L. J.

    2017-01-01

    Queuing Theory is a method to analyze the combat effectiveness of air defense missile weapon system. The model of service probability based on the queuing theory was constructed, and applied to analyzing the combat effectiveness of "Sidewinder" and "Tor-M1" air defense missile weapon system. Finally aimed at different targets densities, the combat effectiveness of different combat units of two types' defense missile weapon system is calculated. This method can be used to analyze the usefulness of air defense missile weapon system.

  12. Capsules with external navigation and triggered release.

    Science.gov (United States)

    Shchukin, Dmitry G; Shchukina, Elena

    2014-10-01

    Encapsulation is an important technology for pharmaceutical industry, food production, et cetera. Its current level of development requires capsule functionalization. One of the interesting ideas to provide new functionality to the microcapsule and nanocapsule is layer-by-layer deposition of functional species. This technique provides step-by-step adsorption of various species (polyelectrolytes, nanoparticles, proteins) when the layer growth is controlled by electrostatic, hydrogen bonding, hydrophobic forces and forming multilayer shells with nanometer precision. This review article introduces recent achievements of layer-by-layer technique attaining external navigation ability and release properties the capsule shell.

  13. Iranian Ballistic Missile Threat and a Phased, Adaptive Approach for Missile Defense in Europe: Perceptions, Policies and Scenarios

    Science.gov (United States)

    2010-09-15

    critical challenges that endanger peace. The institute has offices in New York, Brussels and Moscow. In May 2009, EWI published a report titled...Program: Treading Water in Shark -Infested Seas,” The Heritage Foundation, April 8, 2010, http://www.heritage.org/Research/Reports/2010/04/The-Obama...Administrations-Ballistic-Missile- Defense-Program-Treading-Water-in- Shark -Infested-Seas. 129 Ibid. 57 an ICBM until 2020 (using the SM-3 Block

  14. Ballistic Missile Defense System Transition and Transfer Process from Missile Defense Agency to the Army - Innovative or Dysfunctional?

    Science.gov (United States)

    2010-04-14

    initiating development of the nuclear-capable Nike Zeus ABM interceptor, intended to destroy an incoming enemy warhead with an airborne nuclear explosion. The...intercept an incoming warhead using the nuclear-tipped Nike Zeus missile. Although DoD cancelled the Nike Zeus system due to technical and operational...budgeting, and initiate issue resolution through the Army/MDA Board of Directors to ensure adequate representation of the Service’s interests

  15. Missiles for Asia The Need for Operational Analysis of U.S. Theater Ballistic Missiles in the Pacific

    Science.gov (United States)

    2016-01-01

    attack a skilled TEL force. During the Gulf War, Iraqi TELs were able to continue firing TBMs at Israel , Saudi Arabia, and Bahrain despite a concerted...1, 2015: http://www.defenseindustrydaily.com/agm-158-jassm-lockheeds- family-of-stealthy-cruise-missiles-014343/ Binnie, Jeremy, “ Israel , Syria...Secretary of the Army and was conducted within the RAND Arroyo Center’s Strategy, Doctrine, and Resources Program. RAND Arroyo Center, part of the RAND

  16. The Apache Longbow-Hellfire Missile Test at Yuma Proving Ground: Ecological Risk Assessment for Missile Firing

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Daniel Steven [ORNL; Efroymson, Rebecca Ann [ORNL; Hargrove, William Walter [ORNL; Suter, Glenn [U.S. Environmental Protection Agency; Pater, Larry [ERDC-CERL

    2008-01-01

    A multiple stressor risk assessment was conducted at Yuma Proving Ground, Arizona, as a demonstration of the Military Ecological Risk Assessment Framework. The focus was a testing program at Cibola Range, which involved an Apache Longbow helicopter firing Hellfire missiles at moving targets, M60- A1 tanks. This paper describes the ecological risk assessment for the missile launch and detonation. The primary stressor associated with this activity was sound. Other minor stressors included the detonation impact, shrapnel, and fire. Exposure to desert mule deer (Odocoileus hemionus crooki) was quantified using the Army sound contour program BNOISE2, as well as distances from the explosion to deer. Few effects data were available from related studies. Exposure-response models for the characterization of effects consisted of human "disturbance" and hearing damage thresholds in units of C-weighted decibels (sound exposure level) and a distance-based No Observed Adverse Effects Level for moose and cannonfire. The risk characterization used a weight-of-evidence approach and concluded that risk to mule deer behavior from the missile firing was likely for a negligible number of deer, but that no risk to mule deer abundance and reproduction is expected.

  17. Biodistribution of polymer hydrogel capsules for the delivery of therapeutics.

    Science.gov (United States)

    Hinton, Tracey M; Monaghan, Paul; Green, Diane; Kooijmans, Sander A A; Shi, Shuning; Breheney, Kerry; Tizard, Mark; Nicolazzo, Joseph A; Zelikin, Alexander N; Wark, Kim

    2012-09-01

    A key phase in the development of intelligently designed nanoparticle delivery vehicles for new therapeutic agents is to gain an understanding of their interaction with tissues and cells. We report a series of in vitro and in vivo experiments aimed at tracking a potential delivery vehicle for therapeutic agents, including vaccine peptides and drugs derived from poly(methacrylic acid) hydrogel capsules in certain organs and cell types. For the in vitro studies, two immortal liver-derived cell lines (Huh7 and Hepa1-6) and primary cultures of mouse hepatocytes were incubated with Alexa 647 labelled fluorescent capsules to track their internalization and intracellular distribution by confocal microscopy. Capsules, 500nm in diameter, were taken up into the cells in a time-dependent manner in all three cell lines. Capsules were observed in plasma membrane-derived vesicles within the cells. After 24h a significant proportion of the capsules was observed in lysosomes. To understand the behaviour of the capsules in vivo, Alexa 488 labelled fluorescent capsules were intravenously injected into Sprague-Dawley rats and after 24h the fate of the capsules in a number of organs was determined by flow cytometry and confocal microscopy. By flow cytometry, the majority of the capsules were detected in the spleen whilst similar numbers were found in the lung and liver. By confocal microscopy, the majority of the capsules were found in the liver and spleen with significantly less capsules in the lung, heart and kidney. Colocalization of capsules with cell-type specific markers indicated that in lung, heart and kidney, the majority of the capsules were located in endothelial cells. In the spleen ~50% of the capsules were found in CD163-positive cells, whereas in the liver, almost all capsules were located in CD163-positive cells, indicating uptake by Kupffer cells. Electron microscopy confirmed the presence of capsules within Kupffer cells. Crown Copyright © 2012. Published by

  18. Capsule endoscopy: Current status in obscure gastrointestinal bleeding

    Institute of Scientific and Technical Information of China (English)

    R Gupta; Nageshwar Duvvuru Reddy

    2007-01-01

    Capsule endoscopy (CE) is a safe, non invasive diagnostic modality for the evaluation of small bowel lesions. Obscure gastrointestinal bleeding (OGIB) is one of the most important indications of capsule endoscopy.Capsule endoscopy has a very high diagnostic yield especially if the bleeding is ongoing. This technique appears to be superior to other techniques for the detection of suspected lesions and the source of bleeding. Capsule endoscopy has been shown to change the outcome in patients with obscure gastrointestinal (GI)bleed.

  19. 21 CFR 520.90a - Ampicillin capsules.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Ampicillin capsules. 520.90a Section 520.90a Food... DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.90a Ampicillin capsules. (a) Specifications. Each capsule contains 125 milligrams or 250 milligrams of ampicillin. (b) Sponsor. See No. 000008...

  20. 21 CFR 520.580 - Dichlorophene and toluene capsules.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Dichlorophene and toluene capsules. 520.580 Section 520.580 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Dichlorophene and toluene capsules. (a) Specifications. Each soft gelatin capsule contains 50 milligrams of...

  1. 21 CFR 520.1920 - Prochlorperazine, isopropamide sustained release capsules.

    Science.gov (United States)

    2010-04-01

    ... capsules. 520.1920 Section 520.1920 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... § 520.1920 Prochlorperazine, isopropamide sustained release capsules. (a) Specifications. Prochlorperazine, isopropamide sustained release capsules contain either: (1) 3.33 milligrams of prochlorperazine...

  2. 21 CFR 520.260 - n-Butyl chloride capsules.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false n-Butyl chloride capsules. 520.260 Section 520.260... DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.260 n-Butyl chloride capsules. (a)(1) Specifications. n-Butyl chloride capsules, veterinary contain 272 milligrams or 816 milligrams...

  3. 21 CFR 520.1804 - Piperazine phosphate capsules.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Piperazine phosphate capsules. 520.1804 Section 520.1804 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... phosphate capsules. (a) Specifications. Each capsule contains 120, 300, or 600 milligrams of piperazine...

  4. 21 CFR 520.90c - Ampicillin trihydrate capsules.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Ampicillin trihydrate capsules. 520.90c Section 520.90c Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... trihydrate capsules. (a) Specifications. Each capsule contains ampicillin trihydrate equivalent to 125, 250...

  5. 21 CFR 520.608 - Dicloxacillin sodium monohydrate capsules.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Dicloxacillin sodium monohydrate capsules. 520.608 Section 520.608 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Dicloxacillin sodium monohydrate capsules. (a) Specifications. Each capsule contains dicloxacillin sodium...

  6. 21 CFR 520.622d - Diethylcarbamazine citrate capsules.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Diethylcarbamazine citrate capsules. 520.622d Section 520.622d Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Diethylcarbamazine citrate capsules. (a) Specifications. Each capsule contains 12.5, 50, 200, or 400 milligrams (mg...

  7. 21 CFR 872.3110 - Dental amalgam capsule.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Dental amalgam capsule. 872.3110 Section 872.3110...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3110 Dental amalgam capsule. (a) Identification. A dental amalgam capsule is a container device in which silver alloy is intended to be mixed with...

  8. Ingestible capsule for remote controlled release of a substance

    DEFF Research Database (Denmark)

    2014-01-01

    The application relates to an ingestible capsule (102) for delivery of a substance e.g. a pharmaceutical drug, to a human or animal. The ingestible capsule comprises a capsule wall structure (202) forming a substantially sealed reservoir or lumen holding the substance (204). An electrical resonan...

  9. Electrohydrodynamic deformation of capsules in electric field

    Science.gov (United States)

    Das, Sudip; Thaokar, Rochish

    2016-11-01

    Micron size capsules are abundant in natural, technological and biological processes but they still require extensive investigation for better understanding of their mechanical behavior. A spherical capusle containing a Newtonian fluid bounded by a viscoelastic membrane and immersed in another Newtonian fluid, and subject to electric field is considered. Discontinuity of electrical properties such as conductivity and permittivity leads to a net Maxwell stress at the capsule interface. In response the capsule undergoes elastic deformation, leading to strain fields and elastic stresses that can balance the applied forces. We investigate this problem with fully resolved hydrodynamics in the Stokes flow limit and electrostatics using the capacitance model. Effect of AC, DC and pulsed DC fields is investigated. Our results show that membrane electrical properties have a huge impact on the equilibrium deformation as well as on the break up of capsules. Our results match with the literature results in the limit of high conductance of the membrane. Analytical theory is employed using spherical harmonics and numerical investigations are conducted using the Boundary integral method.

  10. Student Mobility. Information Capsule. Volume 0608

    Science.gov (United States)

    Blazer, Christie

    2007-01-01

    Mobility, rather than stability, has become the norm for students in schools across the United States. The student mobility rate is now higher in the United States than in any other industrialized country. This Information Capsule discusses the reasons for student mobility and the characteristics of highly mobile students and families. Research…

  11. Design of Endoscopic Capsule With Multiple Cameras.

    Science.gov (United States)

    Gu, Yingke; Xie, Xiang; Li, Guolin; Sun, Tianjia; Wang, Dan; Yin, Zheng; Zhang, Pengfei; Wang, Zhihua

    2015-08-01

    In order to reduce the miss rate of the wireless capsule endoscopy, in this paper, we propose a new system of the endoscopic capsule with multiple cameras. A master-slave architecture, including an efficient bus architecture and a four level clock management architecture, is applied for the Multiple Cameras Endoscopic Capsule (MCEC). For covering more area of the gastrointestinal tract wall with low power, multiple cameras with a smart image capture strategy, including movement sensitive control and camera selection, are used in the MCEC. To reduce the data transfer bandwidth and power consumption to prolong the MCEC's working life, a low complexity image compressor with PSNR 40.7 dB and compression rate 86% is implemented. A chipset is designed and implemented for the MCEC and a six cameras endoscopic capsule prototype is implemented by using the chipset. With the smart image capture strategy, the coverage rate of the MCEC prototype can achieve 98% and its power consumption is only about 7.1 mW.

  12. Kinetic simulation of hydrodynamic equivalent capsule implosions

    Science.gov (United States)

    Kwan, Thomas; Le, Ari; Schmitt, Mark; Herrmann, Hans

    2016-10-01

    We have carried out simulations of direct-drive hydrodynamic equivalent capsule implosion experiments conducted on Omega laser facility at the Laboratory of Laser Energetics of the University of Rochester. The capsules had a glass shell (SiO2) 4.87 μm with an inner diameter of 1086 μm. One was filled with deuterium (D) and tritium (T) at 6.635 and 2.475 atmospheric pressure respectively. The other capsule with D, T, and He-3 at 2.475, 2.475, and 5.55 atmospheric pressure respectively. The capsules were imploded with 60 laser beams with a square pulse length of 0.6ns of total energy of 15.6 kJ. One-dimensional radiation hydrodynamic calculations with HYDRA and kinetic particle/hybrid simulations with LSP are carried out for the post-shot analysis. HYDRA outputs at 0.6ns are linked to LSP, in which the electrons are treated as a fluid while all the ion dynamics is simulated by the standard particle-in-cell technique. Additionally, simulations with the new photon package in LSP are initiated at the beginning of the implosion to include the implosion phase of the capsule. The simulation results of density, temperature, and velocity profiles of the electrons, D, T, He-3, and SiO2species are compared with HYDRA. Detail comparisons among the kinetic simulations, rad-hydro simulations, and experimental results of neutron yield, yield ratio, fusion burn histories, and shell convergence will be presented to assess plasma kinetic effects. Work performed under the auspices of the US DOE by the Los Alamos National Laboratory under Contract No. W7405-ENG-36.

  13. Utility of MR arthrography in the diagnosis of adhesive capsulitis

    Energy Technology Data Exchange (ETDEWEB)

    Manton, G.L.; Schweitzer, M.E.; Weishaupt, D.; Karasick, D. [Dept. of Radiology, Thomas Jefferson Univ. Hospital, Philadelphia, PA (United States)

    2001-06-01

    Objective. Arthrographically, adhesive capsulitis is characterized by decreased joint volume; histologically, the capsule and synovium are thickened. We therefore compared using MR arthrography the joint volumes and capsule/synovial thickness of patients with and without adhesive capsulitis in order to assess the utility of MR arthrography in diagnosing adhesive capsulitis.Design and patients. The 1.5 T MR arthrography images of 28 subjects with (n=9) and without (n=19) adhesive capsulitis were compared. Adhe- sive capsulitis was diagnosed when there was an injected glenohumeral joint volume of less than 10 ml. Two masked observers working in consensus assessed the images for the relative amount of fluid in the biceps tendon sheath and axillary recess, corrugation at the margin of the capsule, capsule/synovial thickness, abnormalities of the rotator interval capsule, and for the presence of a cuff tear.Results. There was a trend towards differences in capsular and synovial thickness (P>0.07) between the subjects with and without adhesive capsulitis; however, the controls had thicker synovium/capsules. Surprisingly, the amount of fluid in the axillary recess and biceps tendon sheath was not significantly different between the groups (P>0.25). There were more tears of the rotator cuff in controls than in patients with adhesive capsulitis (6, 3 vs 1, 1: complete, partial). Also, both corrugation (7 vs 0) and interval abnormalities (7 vs 0) were more common in the controls.Conclusion. There appear to be no useful MR arthrographic signs of adhesive capsulitis. Capsular/synovial thickness, static fluid volume, and the presence of corrugation are inconclusive as MR arthrographic signs for distinguishing shoulders with adhesive capsulitis from those without. (orig.)

  14. Zero-sum versus nonzero-sum differential game approach to missile guidance

    NARCIS (Netherlands)

    Trottemant, E.J.; Vermeulen, A.; Weiss, M.

    2007-01-01

    New developments and improvements on evasive missiles have led to a situation in which the current missile guidance laws have difficulties to intercept maneuvering targets. The nature of the interception problem with 2 non-cooperative players leads to the field of differential games. Recent studies

  15. Discussion of the target-missile control scheme with supersonic speed at minimum altitude

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    An antiship missile with supersonic speed at minimum altitude is an effective weapon to break through a defense line. The former Soviet Union was a leader in this field since it had developed several kinds of antiship missiles which obtained supersonic speed at minimum altitudes. To counter this kind of missile,many countries have been developing corresponding antimissiles. For the purpose of verifing the antimissile missile's effectiveness in intercepting antiship missiles, a target-missile is needed. A target-missle is cheaper and can imitate the main characteristics of antiship missiles with supersonic speed at minimum altitude. In this paper, the control scheme of a target missile flying with supersonic speed at minimum altitude is studied. To counter the problem of hedgehopping over the sea, a control scheme utilizing a SINS + altimeter was proposed.In this scheme, both the quick response ability of altitude control and the anti-jamming problem were considered. A simulation experiment shows that when an integrated altitude control system is used, the anti-disturbance ability of the integrated altitude is good and the response speed of altitude control system can be dramatically improved.

  16. 48 CFR 225.7016 - Restriction on Ballistic Missile Defense research, development, test, and evaluation.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restriction on Ballistic Missile Defense research, development, test, and evaluation. 225.7016 Section 225.7016 Federal Acquisition... Acquisition 225.7016 Restriction on Ballistic Missile Defense research, development, test, and evaluation. ...

  17. A modular ducted rocket missile model for threat and performance assessment

    NARCIS (Netherlands)

    Mayer, A.E.H.J.; Halswijk, W.H.C.; Komduur, H.J.; Lauzon, M.; Stowe, R.A.

    2005-01-01

    A model was developed to predict the thrust of throttled ramjet propelled missiles. The model is called DRCORE and fulfils the growing need to predict the performance of air breathing missiles. Each subsystem of the propulsion unit of this model is coded by using engineering formulae and enables the

  18. Symptomatic Patency Capsule Retention in Suspected Crohn's Disease

    DEFF Research Database (Denmark)

    Rasmussen, Bjørn; Nathan, Torben; Jensen, Michael Dam

    2016-01-01

    The main limitation of capsule endoscopy is the risk of capsule retention. In patients with suspected Crohn's disease, however, this complication is rare, and if a small bowel stenosis is not reliably excluded, small bowel patency can be confirmed with the Pillcam patency capsule. We present two...... patients examined for suspected Crohn's disease who experienced significant symptoms from a retained patency capsule. Both patients had Crohn's disease located in the terminal ileum. In one patient, the patency capsule caused abdominal pain and vomiting and was visualized at magnetic resonance enterography...

  19. Making sense of ballistic missile defense: an assessment of concepts and systems for U.S. boost-phase missile defense in comparison to other alternatives

    National Research Council Canada - National Science Library

    Division on Engineering and Physical Sciences; National Research Council; Naval Studies Board

    2012-01-01

    "The Committee on an Assessment of Concepts and Systems for U.S. Boost-Phase Missile Defense in Comparison to Other Alternatives set forth to provide an assessment of the feasibility, practicality, and affordability of U.S...

  20. Missile Sites, Former missile field for Whiteman., Published in 2005, 1:12000 (1in=1000ft) scale, Whiteman Air Force Base.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Missile Sites dataset, published at 1:12000 (1in=1000ft) scale, was produced all or in part from Field Survey/GPS information as of 2005. It is described as...

  1. Simulation Analysis of Wave Effect on Exceeding Water Gesture and Load of Submarine Launched Missile

    Directory of Open Access Journals (Sweden)

    Ke Zhao

    2014-02-01

    Full Text Available In this study, we have a research on wave action on the submarine launched missile water trajectory and gesture angles during the process between launch and exit from water. Infinite water depth plane wave was used as the wave model, mathematics models of missile exceeding water under different wave conditions were established based on ideal potential flow theory. The flow field velocity potential was obtained by solving the Laplace equation, thus can obtain missile surface pressure. Considering free surface effects, simple Green’s function was introduced to solve boundary value problems. Three-dimensional Fortran program and finite software ABAQUS were combined to complete the fluid-structure interaction simulation. The rules that wave level and phases effects on submarine-launched missile were finally obtained, which shows wave affect cannot be neglected. Simulation methods and results of this study have a certain reference value for the submarine-launched missile launching.

  2. RUPTURE OF THIN METAL TUBES BY NORMAL AND OBLIQUE IMPACT OF BLUNT CONICALNOSED MISSILES: EXPERIMENTS

    Institute of Scientific and Technical Information of China (English)

    Mu Jianchun; Zhang Tieguang

    2000-01-01

    Impact tests at both normal and oblique angles of incidence were .conducted on thin mild tubes using a moderate size of 90° conical-nosed missiles. Tne minimum impact speed that generated cracks through the thickness of the wall, termed the speed for rupture, was measured, and various modes of rupture were identified. For a thin tube hit by a missile at a normal angle of obliquity at the speed for rupture, the contact region spreads across the nose of the missile, and the transverse shear deformation is predominant in the final failure process. If the angle of obliquity is 30°, the missile pierces a hole through the wall of the tube. At the speed for rupture, the kinetic energy of the missile for oblique angle 30° is only about 45 % that required for plugging at a normal angle of obliquity.

  3. Ballistic Missile Defense System (BMDS) Programmatic Environmental Impact Statement

    Science.gov (United States)

    2007-01-01

    for decommissioning the BMDS to prot(lct the Uruted ~tatoo lU.~.J . ns depbyed forces . friends. and aUlas hom b~Uistic missile throats. The...intcr~contincmal balh:. tic 7) The President would, m reaffirm the entire L’l’- de\\’cl<I•Pmcn:, human rigl:ts ~;caic. leader the ratitlcatlon...aspi."Ct’< oft he Balli~ tic Miss1k DetCnsc (BMD) pwgrarn. Acid rain; The MDA ihcl:·noti..’S i:1 the ?EIS the pn:.sibility cfa..:id rain cuuseC

  4. Reserve lithium-thionyl chloride battery for missile applications

    Science.gov (United States)

    Planchat, J. P.; Descroix, J. P.; Sarre, G.

    A comparative performance study has been conducted for silver-zinc, thionyl chloride, and thermal batteries designed for such missile applications as ICBM guidance system power supplies. Attention is given to each of the three candidates' conformity to requirements concerning mechanical configuration, electrochemical design, electrolyte reservoir, external case, and gas generator. The silver-zinc and Li-SOCl2 candidates employ similar cell configurations and yield comparable performance. The thermal battery is found to be incapable of meeting battery case temperature-related requirements.

  5. Launch Stabilisation System for Vertical Launch of a Missile

    Directory of Open Access Journals (Sweden)

    K. Sreekumar

    2005-07-01

    Full Text Available The launch platform stabilisation control system is a roll-pitch stabilised platform for the vertical launch of a missile from a naval ship. Stabilisation of the launch platform is achievedwith the help of embedded controllers and electro-hydraulic servo control system. The launch platform is stabilised wrt true horizontal with a 2-axis (roll and pitch stabilisation systemconsisting of a gimbal and a set of three high-pressure servo hydraulic actuators. The control system uses rate gyro and tilt sensor feedbacks for stabilising the platform. This paper outlines the details of the launch platform stabilisation control system, results of digital simulation, and the performance during sea trials.

  6. Ballistic missile precession frequency extraction by spectrogram's texture

    Science.gov (United States)

    Wu, Longlong; Xu, Shiyou; Li, Gang; Chen, Zengping

    2013-10-01

    In order to extract precession frequency, an crucial parameter in ballistic target recognition, which reflected the kinematical characteristics as well as structural and mass distribution features, we developed a dynamic RCS signal model for a conical ballistic missile warhead, with a log-norm multiplicative noise, substituting the familiar additive noise, derived formulas of micro-Doppler induced by precession motion, and analyzed time-varying micro-Doppler features utilizing time-frequency transforms, extracted precession frequency by measuring the spectrogram's texture, verified them by computer simulation studies. Simulation demonstrates the excellent performance of the method proposed in extracting the precession frequency, especially in the case of low SNR.

  7. Thermal Battery As A Power Sources In Guided Missiles

    Directory of Open Access Journals (Sweden)

    S. S. Singh

    1973-10-01

    Full Text Available The battery based on low melting eutectic salt mixture electrolyte is thermally activated by raising the temperature of the electrolyte to its melting point. The battery is capable of discharging at very high rates for short duration. The battery employs a combination of elements with low electronegativity and capable of giving higher electrode potentials such as Ca or Mg as anode, a wide variety of eutectic salt electrolytes and various oxides, sulphates, silicates, phosphates, chromates as cathode depolarizers. Only those thermally activated systems which find application as potential power sources in guided missiles are reviewed.

  8. Year 2000 small engine technology payoffs in cruise missiles

    Science.gov (United States)

    Singh, B.; Benstein, E. H.

    1986-01-01

    A study has been conducted for advanced small (450-850 pounds thrust) gas turbine engines for a subsonic strategic cruise missile application, using projected year-2000 technology. Engine performance and configuration analyses were performed for two and three spool turbofan and propfan engine concepts. Mission and Life Cycle Cost (LCC) analyses were performed in which the candidate engines were compared to the baseline engine over a prescribed mission. The advanced technology engines reduced system LCC up to 41 percent relative to the baseline engine. The critical aerodynamic materials and mechanical systems necessary for turbine engine technology were identified.

  9. Renewable Energy Opportunities at White Sands Missile Range, New Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Chvala, William D.; Solana, Amy E.; States, Jennifer C.; Warwick, William M.; Weimar, Mark R.; Dixon, Douglas R.

    2008-09-01

    The document provides an overview of renewable resource potential at White Sands Missile Range (WSMR) based primarily upon analysis of secondary data sources supplemented with limited on-site evaluations. The effort was funded by the U.S. Army Installation Management Command (IMCOM) as follow-on to the 2005 DoD Renewable Energy Assessment. This effort focuses on grid-connected generation of electricity from renewable energy sources and also ground source heat pumps (GSHPs) for heating and cooling buildings, as directed by IMCOM.

  10. Minimum Ballistic Factor Problem of Slender Axial Symmetric Missiles

    Directory of Open Access Journals (Sweden)

    V. B. Tawakley

    1979-01-01

    Full Text Available The problem of determining the geometry of slender, axisymmetric missiles of minimum ballistic factor in hypersonic flow has been solved via the calculus of variations under the assumptions that the flow is Newtonian and the surface averaged skin-friction coefficient is constant. The study has been made for conditions of given length and diameter, given diameter and surfacearea, and given surface area and length. The earlier investigations/sup 8/ where only regular shapes were determined has been extended to cover those class of bodies which consist of regular shapes followed or preceded by zero slope shapes.

  11. Active infrared systems: possible roles in ballistic missile defense?

    Science.gov (United States)

    Paleologue, A.

    2006-05-01

    Active Infra-Red (IR) systems developed in the past ten years are now available for missile defense applications. The main purpose of this paper is to describe the advantages an active IR system could offer to a ballistic missile defense (BMD). The active IR system considered in this paper is a LIDAR (LIght Detection And Ranging) system. Historically, the Lincoln Laboratory in the USA began using lasers in the early 1960's. The initial applications included the development of a LIDAR system enabling the measurement of the distance between the earth and the moon in 1962. Satellite tracking using LIDAR began early in 1973. Today, technological developments, with the miniaturization of systems and increased performance levels, have enabled new ambitious projects such as the Discrimination Interceptor Technology Program (DITP) program started in 1998 and the use of LIDAR to help in the discrimination of future exo-atmospheric interceptors within the framework of BMD. The first part of this paper presents the possible contribution of LIDAR to BMD: the main roles, objectives, and strategic advantages. The second part gives a brief overview of the technological features of a generic LIDAR instrument, rapidly addressing laser sources, detectors, optics and electronics. Finally, a modeling of an IR LIDAR system, limited solely to direct detection, and an estimation of performance levels will be presented. A list of possible IR active discriminators will be then presented on the basis of the previous analysis and proposed as new constraints in the design of discrete objects.

  12. Missile-Borne SAR Raw Signal Simulation for Maneuvering Target

    Directory of Open Access Journals (Sweden)

    Weijie Xia

    2016-01-01

    Full Text Available SAR raw signal simulation under the case of maneuver and high-speed has been a challenging and urgent work recently. In this paper, a new method based on one-dimensional fast Fourier transform (1DFFT algorithm is presented for raw signal simulation of maneuvering target for missile-borne SAR. Firstly, SAR time-domain raw signal model is given and an effective Range Frequency Azimuth Time (RFAT algorithm based on 1DFFT is derived. In this algorithm, the “Stop and Go” (SaG model is adopted and the wide radar scattering characteristic of target is taken into account. Furthermore, the “Inner Pulse Motion” (IPM model is employed to deal with high-speed case. This new RFAT method can handle the maneuvering cases, high-speed cases, and bistatic radar cases, which are all possible in the missile-borne SAR. Besides, this raw signal simulation adopts the electromagnetic scattering calculation so that we do not need a scattering rate distribution map as the simulation input. Thus, the multiple electromagnetic reflections can be considered. Simulation examples prove the effectiveness of our method.

  13. Estimation filters for missile tracking with airborne laser

    Science.gov (United States)

    Clemons, T. M., III; Chang, K. C.

    2006-05-01

    This paper examines the use of various estimation filters on the highly non-linear problem of tracking a ballistic missile during boost phase from a moving airborne platform. The aircraft receives passive bearing data from an IR sensor and range data from a laser rangefinder. The aircraft is assumed to have a laser weapon system that requires highly accurate bearing information in order to keep the laser on target from a distance of 100-200 km. The tracking problem is made more difficult due to the changing acceleration of the missile, especially during stage drop-off and ignition. The Extended Kalman Filter (EKF), Unscented Kalman Filter (UKF), 'bootstrap' Particle Filter (PF), and the Gaussian Sum Particle Filter (GSPF) are explored using different values for sensor accuracy in bearing and range, and various degrees of uncertainty of the target and platform dynamic. Scenarios were created using Satellite Toolkit © for trajectories from a Southeast Asia launch with associated sensor observations. MATLAB © code modified from the ReBEL Toolkit © was used to run the EKF, UKF, PF, and GSPF sensor track filters. Mean Square Error results are given for tracking during the period when the target is in view of the radar and IR sensors. This paper provides insight into the accuracy requirements of the sensors and the suitability of the given estimators.

  14. Characterization of novel lactoferrin loaded capsules prepared with polyelectrolyte complexes.

    Science.gov (United States)

    Wu, Qing-Xi; Zhang, Qi-Lei; Lin, Dong-Qiang; Yao, Shan-Jing

    2013-10-15

    Novel capsules loaded with lactoferrin (LF) were prepared using polyelectrolyte complexes that were formed by water soluble chitosan (WSC), sodium cellulose sulfate (NaCS) and sodium polyphosphate (PPS). Normal chitosan (soluble in acidic conditions) was chosen as a control to prepare similar capsules with NaCS and PPS. (1)H NMR and FTIR spectra analysis showed that WSC was in a form of chitosan hydrochloride which can be directly dissolved and protonated in acid-free water. SEM results showed that the capsules had a typical wall-capsule structure with a regular spherical shape and an average diameter of 1.97 mm. TGA studies revealed that the thermal stability of the capsules were enhanced and the moisture content of the drug-free/loaded capsules were 6.3% and 3.2%. SDS-PAGE results showed that the primary structures of the processed LF in the capsules were unchanged. Drug loading (LE%) and encapsulation efficiency (EE%) analysis showed that the capsules had a higher LE% (45.6%) and EE% (70.7%) than that of the control. In vitro release studies showed that the capsules had a regular and sustainable release profiles in simulated colonic fluid. All of these results indicated that the capsules prepared could be used as a candidate protein drug carrier for colon. Copyright © 2013 Elsevier B.V. All rights reserved.

  15. Basic ammonothermal GaN growth in molybdenum capsules

    Science.gov (United States)

    Pimputkar, S.; Speck, J. S.; Nakamura, S.

    2016-12-01

    Single crystal, bulk gallium nitride (GaN) crystals were grown using the basic ammonothermal method in a high purity growth environment created using a non-hermetically sealed molybdenum (Mo) capsule and compared to growths performed in a similarly designed silver (Ag) capsule and capsule-free René 41 autoclave. Secondary ion mass spectrometry (SIMS) analysis revealed transition metal free (<1×1017 cm-3) GaN crystals. Anomalously low oxygen concentrations ((2-6)×1018 cm-3) were measured in a {0001} seeded crystal boule grown using a Mo capsule, despite higher source material oxygen concentrations ((1-5)×1019 cm-3) suggesting that molybdenum (or molybdenum nitrides) may act to getter oxygen under certain conditions. Total system pressure profiles from growth runs in a Mo capsule system were comparable to those without a capsule, with pressures peaking within 2 days and slowly decaying due to hydrogen diffusional losses. Measured Mo capsule GaN growth rates were comparable to un-optimized growth rates in capsule-free systems and appreciably slower than in Ag-capsule systems. Crystal quality replicated that of the GaN seed crystals for all capsule conditions, with high quality growth occurring on the (0001) Ga-face. Optical absorption and impurity concentration characterization suggests reduced concentrations of hydrogenated gallium vacancies (VGa-Hx).

  16. Motion of an elastic capsule in a square microfluidic channel.

    Science.gov (United States)

    Kuriakose, S; Dimitrakopoulos, P

    2011-07-01

    In the present study we investigate computationally the steady-state motion of an elastic capsule along the centerline of a square microfluidic channel and compare it with that in a cylindrical tube. In particular, we consider a slightly over-inflated elastic capsule made of a strain-hardening membrane with comparable shearing and area-dilatation resistance. Under the conditions studied in this paper (i.e., small, moderate, and large capsules at low and moderate flow rates), the capsule motion in a square channel is similar to and thus governed by the same scaling laws with the capsule motion in a cylindrical tube, even though in the channel the cross section in the upstream portion of large capsules is nonaxisymmetric (i.e., square-like with rounded corners). When the hydrodynamic forces on the membrane increase, the capsule develops a pointed downstream edge and a flattened rear (possibly with a negative curvature) so that the restoring tension forces are increased as also happens with droplets. Membrane tensions increase significantly with the capsule size while the area near the downstream tip is the most probable to rupture when a capsule flows in a microchannel. Because the membrane tensions increase with the interfacial deformation, a suitable Landau-Levich-Derjaguin-Bretherton analysis reveals that the lubrication film thickness h for large capsules depends on both the capillary number Ca and the capsule size a; our computations determine the latter dependence to be (in dimensionless form) h ~ a(-2) for the large capsules studied in this work. For small and moderate capsule sizes a, the capsule velocity Ux and additional pressure drop ΔP+ are governed by the same scaling laws as for high-viscosity droplets. The velocity and additional pressure drop of large thick capsules also follow the dynamics of high-viscosity droplets, and are affected by the lubrication film thickness. The motion of our large thick capsules is characterized by a Ux-U ~ h ~ a(-2

  17. Capsule formation and asymbiotic seed germination in some hybrids of Phalaenopsis, influenced by pollination season and capsule maturity.

    Science.gov (United States)

    Balilashaki, Khosro; Gantait, Saikat; Naderi, Roohangiz; Vahedi, Maryam

    2015-07-01

    We explored the influence of pollination season and maturity of capsule on post-pollination capsule formation and in vitro asymbiotic seed germination, respectively. Three Phalaenopsis orchid hybrids, namely, 'Athens', 'Moscow' and 'Lusaka' flowers were artificially self-pollinated during winter, spring, summer and fall seasons and the impact of the pollination seasons was evident during capsule formation. It was observed that winter was the most suitable season for pollination of all the three Phalanaeopsis hybrids resulting in 80-88 % capsule formation. During summer, the pollination success rate was 24-28 %, but resulted in successful capsule formation. Season of pollination further delimited the germination efficiency of seeds harvested from capsules of variable maturity levels. Invariably, seeds collected from winter-pollinated capsules performed best in germination compared to other seasons, for instance, 'Moscow' seeds took less than 14 days to germinate from capsules developed following winter-pollination. Regarding the influence of capsule maturity on seed germination, we observed that seeds derived from 5-month mature capsules, invariably took least time to germinate than that of the 3-month or 7-month in all three hybrids, e.g., for 'Moscow' it was 13.9 days with a maximum of 90.3 % germination.

  18. Comprehensive and Systematic Analysis of the Immunocompatibility of Polyelectrolyte Capsules.

    Science.gov (United States)

    Zyuzin, Mikhail V; Díez, Paula; Goldsmith, Meir; Carregal-Romero, Susana; Teodosio, Cristina; Rejman, Joanna; Feliu, Neus; Escudero, Alberto; Almendral, María Jesús; Linne, Uwe; Peer, Dan; Fuentes, Manuel; Parak, Wolfgang J

    2017-02-15

    The immunocompability of polyelectrolyte capsules synthesized by layer-by-layer deposition has been investigated. Capsules of different architecture and composed of either non-degradable or biodegradable polymers, with either positively or negatively charged outer surface, and with micrometer size, have been used, and the capsule uptake by different cell lines has been studied and quantified. Immunocompatibility studies were performed with peripheral blood mononuclear cells (PBMCs). Data demonstrate that incubation with capsules, at concentrations relevant for practical applications, did not result in a reduced viability of cells, as it did not show an increased apoptosis. Presence of capsules also did not result in an increased expression of TNF-α, as detected with antibody staining, as well as at mRNA level. It also did not result in increased expression of IL-6, as detected at mRNA level. These results indicate that the polyelectrolyte capsules used in this study are immunocompatible.

  19. The motion of a deforming capsule through a corner

    CERN Document Server

    Zhu, Lailai

    2014-01-01

    A three-dimensional deformable capsule convected through a channel/duct with a corner is studied via numerical simulations using an accelerated boundary integral method adapted to general geometries. A global spectral method is adopted to resolve the dynamics of the capsule's membrane developing elastic tensions according to the Neo-Hookean constitutive law and bending moments in an inertialess flow. The simulations show that the trajectory of the capsule closely follows the underlying streamlines and the deformation of the capsule induces an anti-clockwise rotation of its material points with respect to the travelling direction. The surface area, principle tension and elastic energy of the capsule increase around the corner. Their temporal evolutions are characterised by a clear phase delay and the loss of time-reversal symmetry of Stokes flow due to the elasticity of membrane. The capsule centroid velocity decreases approaching the corner as the mean flow does while a velocity overshoot is observed past the...

  20. Expanding role of capsule endoscopy in inflammatory bowel disease

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Capsule endoscopy has been shown to detect small bowel inflammatory changes better than any other imaging modality. Selection criteria have been optimized to increase the yield of capsule endoscopy in patients suspected to have Crohn's disease. Capsule endoscopy allows for earlier diagnosis of Crohn's disease of the small bowel and improved diagnosis of colitis in patients where it is unclear if they suffer from Crohn's or ulcerative colitis. A test capsule is available to assess for small bowel strictures and thus avoid capsule retention. A common language has been developed and a new scoring index will be added to capsule software. It is envisioned that the manner in which we treat Crohn's disease in the future will change, based on earlier diagnosis and treatment aimed at mucosal healing rather than symptom improvement.

  1. Polar tent for reduced perturbation of NIF ignition capsules

    Science.gov (United States)

    Hammel, B. A.; Pickworth, L.; Stadermann, M.; Field, J.; Robey, H.; Scott, H. A.; Smalyuk, V.

    2016-10-01

    In simulations, a tent that contacts the capsule near the poles and departs tangential to the capsule surface greatly reduces the capsule perturbation, and the resulting mass injected into the hot-spot, compared to current capsule support methods. Target fabrication appears feasible with a layered tent (43-nm polyimide + 8-nm C) for increased stiffness. We are planning quantitative measurements of the resulting shell- ρR perturbation near peak implosion velocity (PV) using enhanced self-emission backlighting, achieved by adding 1% Ar to the capsule fill in Symcaps (4He + H). Layered DT implosions are also planned for an integrated test of capsule performance. We will describe the design and simulation predictions. Prepared by LLNL under Contract DE-AC52-07NA27344.

  2. Analysis Of Wetted-Foam ICF Capsule Perormance

    Science.gov (United States)

    Peterson, R.; Olson, R.; Zylstra, A.; Haines, B.; Yi, A.; Bradley, P.; Yin, L.; Leeper, R.; Kline, J.

    2016-10-01

    The performance of wetted-foam ICF capsules is investigated with the RAGE Eulerian radiation-hydrodynamics computer code. We are developing an experimental platform on NIF that employs a wetted foam liquid DT fuel layer ICF capsules. By varying the capsule temperature, the vapor density in the capsule can be prescribed, and the hot spot convergence ratio (CR) of the capsule implosion can be controlled. This allows us to investigate the fidelity of RAGE in modeling of capsule implosions as the value of CR is varied. In the NIF experiments, CR can be varied from 12 to 25. This presentation will cover simulations with RAGE of three NIF shots performed in 2016; a DD and a DT liquid fuel shot with CR =14 and a DT shot with CR =16. It will also discuss analysis of future experiments. This work was performed under auspices of the U. S. DOE by LANL.

  3. Regional multiaxial mechanical properties of the porcine anterior lens capsule.

    Science.gov (United States)

    David, G; Pedrigi, R M; Heistand, M R; Humphrey, J D

    2007-02-01

    The lens capsule of the eye plays fundamental biomechanical roles in both normal physiological processes and clinical interventions. There has been modest attention given to the mechanical properties of this important membrane, however, and prior studies have focused on 1-D analyses of the data. We present results that suggest that the porcine anterior lens capsule has a complex, regionally dependent, nonlinear, anisotropic behavior. Specifically, using a subdomain inverse finite element method to analyze data collected via a new biplane video-based test system, we found that the lens capsule is nearly isotropic (in-plane) near the pole but progressively stiffer in the circumferential compared to the meridional direction as one approaches the equator. Because the porcine capsule is a good model of the young human capsule, there is strong motivation to determine if similar regional variations exist in the human lens capsule for knowledge of such complexities may allow us to improve the design of surgical procedures and implants.

  4. Role of shocks and mix caused by capsule defects

    Science.gov (United States)

    Bradley, P. A.; Cobble, J. A.; Tregillis, I. L.; Schmitt, M. J.; Obrey, K. D.; Glebov, V.; Batha, S. H.; Magelssen, G. R.; Fincke, J. R.; Hsu, S. C.; Krasheninnikova, N. S.; Murphy, T. J.; Wysocki, F. J.

    2012-09-01

    An Eulerian code with a turbulent mix model is used to model a set of plastic (CH) ablator capsules with and without equatorial grooves. The "perfect" capsule results were used to calibrate simulations of capsules with equatorial grooves of different depths that provided information on increasingly perturbed implosions. Simulations with a turbulence model were able to calculate the same yield over mix (YOM) ratio (experiment/mix simulation) of 0.2 to 0.3 for thin (8-μm thick) and thick shell (15-μm thick) capsules with no grooves and thin capsules with shallow grooves. When the capsules have deep grooves, the YOM ratio increases to greater than unity, probably because the deformed shocks focus too strongly on the symmetry axis in our two-dimensional simulations. This is supported by a comparison of simulated and experimental x-ray images.

  5. Gelatin and Non-Gelatin Capsule Dosage Forms.

    Science.gov (United States)

    Gullapalli, Rampurna P; Mazzitelli, Carolyn L

    2017-06-01

    Capsules offer an alternate to tablets for oral delivery of therapeutic compounds. One advantage of capsules over tablets is their amenability to deliver not only solids but also nonaqueous liquids and semisolids as a unit dose solid dosage form. Shell component is an essential part of capsule dosage forms. Capsule shells, available as hard or soft shells, are formulated from gelatin or a non-gelatin polymeric material such as hypromellose and starch, water, and with or without a nonvolatile plasticizer. The capsule shells may also be formulated to modify the release of their fill contents in a site-specific manner in the gastrointestinal tract. The goal of the current review is to provide an in-depth discussion on polymeric film-forming materials and manufacturing technologies used in the production of capsule shells. Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

  6. Capsule development and utilization for material irradiation tests

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Young Hwan; Kim, B. G.; Joo, K. N. [and others

    2000-05-01

    The development program of advanced nuclear structural and fuel materials includes the in-pile tests using the instrumented capsule at HANARO. The tests were performed in the in-core test holes of CT, IR 1 and 2 and OR 4 and 5 of HANARO. Extensive efforts have also been made to establish design and manufacturing technology for the instrumented capsule and its related system, which should be compatible with the HANARO's characteristics. Since the first instrumented capsule(97M-01K) had been designed and successfully fabricated, five tests were done to support the users and provided the economic benefits to user by generating the essential in-pile information on the performance and structural integrity of materials. This paper describes the present status and future plans of these R and D activities for the development of the instrumented capsule including in-situ material property measurement capsules and nuclear fuel test capsules.

  7. Design of a slow-release capsule using laser drilling.

    Science.gov (United States)

    Jain, N K; Naik, S U

    1984-12-01

    Conventional hard gelatin capsules were made GI-tract resistant by formalin vapor treatment. The residual formalin content was 80 micrograms/capsule 24 h after treatment, which decreased with increased storage time. An in vitro GI-tract resistance test was performed by exposing the capsules to simulated gastric fluid for 4 h and then to simulated intestinal fluid for 4 h at 37 degrees C. The resistance was further confirmed by in vivo X-ray studies in human volunteers. Minute pores were drilled on the hardened shells of the capsules with a carbon dioxide gas laser. This permitted the slow passage of the encapsulated tetracycline hydrochloride when subjected to 0.1 M HCl in in vitro dissolution studies. In vitro drug release from these capsules followed zero-order kinetics after an initial lag period of 30 min. The factors influencing the in vitro release rate of tetracycline hydrochloride from these capsules are discussed.

  8. AIM-120 Advanced Medium Range Air-to-Air Missile (AMRAAM)

    Science.gov (United States)

    2015-12-01

    Selected Acquisition Report (SAR) RCS: DD-A&T(Q&A)823-185 AIM-120 Advanced Medium Range Air-to-Air Missile (AMRAAM) As of FY 2017 President’s...17, 2013 Program Information Program Name AIM-120 Advanced Medium Range Air-to-Air Missile (AMRAAM) DoD Component Air Force Joint Participants...December 2015 SAR March 23, 2016 16:04:24 UNCLASSIFIED 5 Mission and Description The Advanced Medium Range Air-to-Air Missile (AMRAAM) AIM-120

  9. Study on Missile Intelligent Fault Diagnosis System Based on Fuzzy NN Expert System

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    In order to study intelligent fault diagnosis methods based on fuzzy neural network (NN) expert systemand build up intelligent fault diagnosis for a type of mis-sile weapon system, the concrete implementation of a fuzzyNN fault diagnosis expert system is given in this paper. Based on thorough research of knowledge presentation, theintelligent fault diagnosis system is implemented with artificial intelligence for a large-scale missile weapon equipment.The method is an effective way to perform fuzzy fault diagnosis. Moreover, it provides a new way of the fault diagnosisfor large-scale missile weapon equipment.

  10. Analysis Of The Infrared Emission Due To Aerodynamic Heating Of Missile Domes

    Science.gov (United States)

    Tofani, Alessandro

    1989-09-01

    A computer simulation of head-on infrared emission from missile noses has been performed. Both cruise missiles and tactical ballistic missiles were considered; results indicate a strong dependence of the emitted radiation on physical and geometrical properties of aerodynamic surfaces, flow character in the boundary layer and atmospheric characteristics. The model allows to give an order-of-magnitude estimate of radiant intensity in the 8-12 μm and 3-5 μm spectral bands and to determine their relative merits as far as the target detection is concerned.

  11. Multiple internalization pathways of polyelectrolyte multilayer capsules into mammalian cells.

    Science.gov (United States)

    Kastl, Lena; Sasse, Daniel; Wulf, Verena; Hartmann, Raimo; Mircheski, Josif; Ranke, Christiane; Carregal-Romero, Susana; Martínez-López, José Antonio; Fernández-Chacón, Rafael; Parak, Wolfgang J; Elsasser, Hans-Peter; Rivera Gil, Pilar

    2013-08-27

    Polyelectrolyte multilayer (PEM) capsules are carrier vehicles with great potential for biomedical applications. With the future aim of designing biocompatible, effective therapeutic delivery systems (e.g., for cancer), the pathway of internalization (uptake and fate) of PEM capsules was investigated. In particular the following experiments were performed: (i) the study of capsule co-localization with established endocytic markers, (ii) switching-off endocytotic pathways with pharmaceutical/chemical inhibitors, and (iii) characterization and quantification of capsule uptake with confocal and electron microscopy. As result, capsules co-localized with lipid rafts and with phagolysosomes, but not with other endocytic vesicles. Chemical interference of endocytosis with chemical blockers indicated that PEM capsules enter the investigated cell lines through a mechanism slightly sensitive to electrostatic interactions, independent of clathrin and caveolae, and strongly dependent on cholesterol-rich domains and organelle acidification. Microscopic characterization of cells during capsule uptake showed the formation of phagocytic cups (vesicles) to engulf the capsules, an increased number of mitochondria, and a final localization in the perinuclear cytoplasma. Combining all these indicators we conclude that PEM capsule internalization in general occurs as a combination of different sequential mechanisms. Initially, an adsorptive mechanism due to strong electrostatic interactions governs the stabilization of the capsules at the cell surface. Membrane ruffling and filopodia extensions are responsible for capsule engulfing through the formation of a phagocytic cup. Co-localization with lipid raft domains activates the cell to initiate a lipid-raft-mediated macropinocytosis. Internalization vesicles are very acidic and co-localize only with phagolysosome markers, excluding caveolin-mediated pathways and indicating that upon phagocytosis the capsules are sorted to

  12. Multicomposite ultrathin capsules for sustained ocular delivery of ciprofloxacin hydrochloride.

    Science.gov (United States)

    Bhadra, Dipankar; Gupta, Girish; Bhadra, Sulekha; Umamaheshwari, R B; Jain, Narendra

    2004-07-16

    The present work is intended to develop a sustained bioadhesive drug delivery system for delivery of Ciprofloxacin Hydrochloride in Cul-de-Sac for sustained and effective antimicrobial chemotherapy. For this, ultrathin multicomposite capsular systems were selected. Multicomposite ultrathin capsules are molecular assemblies of tailored architecture having layer-by-layer adsorption of oppositely charged macromolecules onto colloidal particles. In the present study colloidal calcium phosphate core and gluateraldehyde fixed RBCs were used as core on which alginate (-vely charged) and polyallylamine hydrochloride (+vely charged) polyelectrolyte coating was deposited alternatively upto 10th layer. The coating in each subsequent layer was determined by changes in zeta potential. Ciprofloxacin hydrochloride was loaded in the capsules by incubation with the capsules suspended in phosphate buffer saline pH 7.4. The cores of the capsules were then removed by treatment with 0.1N HCl for calcium phosphate core and by sodium hypochlorite for RBC cored capsules. The hollow ciprofloxacin HCl loaded capsules were the evaluated in-vitro for pattern of layer-by-layer drug loading, drug release, stability at various temperatures and ionic concentrations and corneal retention. The core removal process was found to have minimal effects on drug loading in capsules. The drug loading was found to be higher for RBC cored hollow capsules and hence release rate was lower as compared to calcium cored hollow capsules. Draize test for corneal irritancy proved that the capsules were not irritating. The capsules were found to deliver the ciprofloxacin in cul-de-sac of rabbit's eyes for prolonged period. Based on corneal retention studies and tear drug concentration, the capsules can be considered for suitable and safe use for sustained ocular delivery of drugs.

  13. 21 CFR 520.1921 - Prochlorperazine, isopropamide, with neomycin sustained-release capsules.

    Science.gov (United States)

    2010-04-01

    ... sustained-release capsules. 520.1921 Section 520.1921 Food and Drugs FOOD AND DRUG ADMINISTRATION... capsules. (a) Specifications. Each capsule contains either: (1) Capsule No. 1: 3.33 milligrams of... base (as the sulfate); or (2) Capsule No. 3: 10 milligrams of prochlorperazine (as the dimaleate), 5...

  14. Capsule shields the function of short bacterial adhesins

    DEFF Research Database (Denmark)

    Schembri, Mark; Dalsgaard, D.; Klemm, Per

    2004-01-01

    Bacterial surface structures such as capsules and adhesins are generally regarded as important virulence factors. Here we demonstrate that capsules block the function of the self-recognizing protein antigen 43 through physical shielding. The phenomenon is not restricted to Escherichia coli but can...... occur in other gram-negative bacteria. Likewise, we show that other short adhesins exemplified by the AIDA-I protein are blocked by the presence of a capsule. The results support the notion that capsule polysaccharides sterically prevent receptor-target recognition of short bacterial adhesins...

  15. The Thermal Hydraulic Test of SFR Irradiation Test Capsule

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Chul Yong; Park, Sung Jae; Choo, Kee Nam [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2010-10-15

    Irradiation test using a capsule has been performed for fuel or material performance test in the test reactor. Irradiation capsule for the HANARO reactor must satisfy the hydraulic conditions and structural integrity from a out-pile test. Items of a out-pile test are pressure drop, flow-induced vibration test and endurance test. The results of test must show that a test capsule satisfy the HANARO operational requirement with sufficient margin. This paper describes the devices of thermal hydraulic test and the results of SFR test capsule

  16. Small intestinal model for electrically propelled capsule endoscopy

    Directory of Open Access Journals (Sweden)

    Woo Sang Hyo

    2011-12-01

    Full Text Available Abstract The aim of this research is to propose a small intestine model for electrically propelled capsule endoscopy. The electrical stimulus can cause contraction of the small intestine and propel the capsule along the lumen. The proposed model considered the drag and friction from the small intestine using a thin walled model and Stokes' drag equation. Further, contraction force from the small intestine was modeled by using regression analysis. From the proposed model, the acceleration and velocity of various exterior shapes of capsule were calculated, and two exterior shapes of capsules were proposed based on the internal volume of the capsules. The proposed capsules were fabricated and animal experiments were conducted. One of the proposed capsules showed an average (SD velocity in forward direction of 2.91 ± 0.99 mm/s and 2.23 ± 0.78 mm/s in the backward direction, which was 5.2 times faster than that obtained in previous research. The proposed model can predict locomotion of the capsule based on various exterior shapes of the capsule.

  17. Campylobacter polysaccharide capsules: virulence and vaccines

    Directory of Open Access Journals (Sweden)

    Patricia eGuerry

    2012-02-01

    Full Text Available Campylobacter jejuni remains a major cause of bacterial diarrhea worldwide and is associated with numerous sequelae, including Guillain Barre Syndrome, inflammatory bowel disease, reactive arthritis, and irritable bowel syndrome. C. jejuni is unusual for an intestinal pathogen in its ability to coat its surface with a polysaccharide capsule (CPS. These capsular polysaccharides vary in sugar composition and linkage, especially those involving heptoses of unusual configuration and O-methyl phosphoramidate linkages. This structural diversity is consistent with CPS being the major serodeterminant of the Penner scheme, of which there are 47 C. jejuni serotypes. Both CPS expression and expression of modifications are subject to phase variation by slip strand mismatch repair. Although capsules are virulence factors for other pathogens, the role of CPS in C. jejuni disease has not been well defined beyond descriptive studies demonstrating a role in serum resistance and for diarrhea in a ferret model of disease. However, perhaps the most compelling evidence for a role in pathogenesis are data that CPS conjugate vaccines protect against diarrheal disease in non-human primates. A CPS conjugate vaccine approach against this pathogen is intriguing, but several questions need to be addressed, including the valency of CPS types required for an effective vaccine. There have been numerous studies of prevalence of CPS serotypes in the developed world, but few studies from developing countries where the disease incidence is higher. The complexity and cost of Penner serotyping has limited its usefulness, and a recently developed multiplex PCR method for determination of capsule type offers the potential of a more rapid and affordable method. Comparative studies have shown a strong correlation of the two methods and studies are beginning to ascertain CPS-type distribution worldwide, as well as examination of correlation of severity of illness with specific CPS types.

  18. A Game-Theoretic History of the Cuban Missile Crisis

    Directory of Open Access Journals (Sweden)

    Frank C. Zagare

    2014-01-01

    Full Text Available This study surveys and evaluates previous attempts to use game theory to explain the strategic dynamic of the Cuban missile crisis, including, but not limited to, explanations developed in the style of Thomas Schelling, Nigel Howard and Steven Brams. All of the explanations were judged to be either incomplete or deficient in some way. Schelling’s explanation is both empirically and theoretically inconsistent with the consensus interpretation of the crisis; Howard’s with the contemporary understanding of rational strategic behavior; and Brams’ with the full sweep of the events that define the crisis. The broad outlines of a more general explanation that addresses all of the foundational questions associated with the crisis within the confines of a single, integrated, game-theoretic model with incomplete information are laid out.

  19. Parametric control systems design with applications in missile control

    Institute of Scientific and Technical Information of China (English)

    DUAN GuangRen; YU HaiHua; TAN Feng

    2009-01-01

    This paper considers parametric control of high-order descriptor linear systems via proportional plus derivative feedback.By employing general parametric solutions to a type of so-called high-order Sylvester matrix equations,complete parametric control approaches for high-order linear systems are presented.The proposed approaches give simple complete parametric expressions for the feedback gains and the closed-loop eigenvector matrices,and produce all the design degrees of freedom.Furthermore,Important special cases are particularly treated.Based on the proposed parametric design approaches,a parametric method for the gain-scheduling controller design of a linear time-varying system is proposed and the design of a BTT missile autopilot is carried out.The simulation results show that the method is superior to the traditional one in sense of either global stability or system performance.

  20. Ballistic Missile Warhead Recognition based on Micro-Doppler Frequency

    Directory of Open Access Journals (Sweden)

    Sun Hui-Xia

    2008-11-01

    Full Text Available To elucidate the spinning-precession signatures of ballistic warhead, the model of spinning precessionfor ballistic missile warhead is established and the mathematics of micro-Doppler signatures caused by spinning-precession is derived. Then the micro-Doppler features are analysed using high-resolution time-frequencytransform, and the model predictions match the experimental data well. Based on  different mass of warheadsand decoys, the feature, which can reflect the mass of the targets, is extracted from the time-frequency plane,proving a new method for recognising warheads and discriminating these from decoys. Finally the validityof the feature extracted in this study is verified by computer simulations even with low signal-to-noise ratio.Defence Science Journal, 2008, 58(6, pp.705-709, DOI:http://dx.doi.org/10.14429/dsj.58.1697

  1. New digital-input transmitter for missile telemetry

    Science.gov (United States)

    Rieger, J. L.; Woodworth, P. H.

    It is pointed out that telemetry for aircraft and missiles has been in use by the military and its suppliers since the 1950's, using a variety of frequencies and formats. However, the techniques used in airborne telemetry have changed as a consequence of advances in electronic technology. Use of digital pulse-code modulation instead of the analog time-sampled pulse-amptitude modulation (PAM) produced by an analog commutator has advantages in noise performance in instances where the telemetry link is performing near the threshold of noise. The present investigation is concerned with a digital-input transmitter which accepts binary format directly from a TTL source and has applicability in both standard telemetry and encrypted systems. Attention is given to telemetry modulation systems, data encryption requirements, the modulation interface, and transmitter characteristics.

  2. Ogive Nose Hard Missile Penetrating Concrete Slab Numerical Simulation Approach

    Directory of Open Access Journals (Sweden)

    Qadir Bux

    2011-01-01

    Full Text Available Great demand exists for more efficient design to protect delicate and serious structures such as nuclear plants, Power plants, Weapon Industries, weapons storage places, water retaining structures, & etc, against impact of kinetic missiles generated both accidentally and deliberately such as dynamic loading, incident occurs in nuclear plants, terrorist attack, Natural disasters like tsunami and etc., in various impact and blast scenarios for both civilian and military activities. In many cases, projectiles can be treated as rigid bodies when their damage and erosion are not severe. Due to the intricacy of the local impact damages, investigations are generally based on experimental data. Conclusions of the experimental observations are then used to guide engineering models. Local damages studies normally fall into three categories, i.e. empirical formulae based on data fitting, idealised analytical models based on physic laws and numerical simulations based on computational mechanics and material models. In the present study, 2D asymmetrical numerical simulation have done on concrete slab against the impact of  ogive nose hard missile of 26.90mm and 76.20mm diameter with CRH ratio 2.0 and 6.0 respectively, for penetration by using Concrete Damaged Plasticity Model, and ABAQUS/Explicit dynamic analysis in ABAQUS. It is found that the strains/stresses are induced in the concrete slab and a very nicely propagation of the stresses inside the  concrete slab in the form of waves, which is a clear indication for vibrations of the concrete. The lack of failure criterion in concrete damaged plasticity model does not allow the removal of elements during the analyses. This means that spalling, scabbing, and perforation cannot be modelled with the Concrete Damage Plasticity Model. The penetration depth results shows that the deeper penetration requires higher critical impact kinetic energies, and comparison shows the simulation results are more accurate

  3. Robust Graded Sliding Mode Tracking Control for Low Speed Spinning Ballistic Missiles

    Institute of Scientific and Technical Information of China (English)

    ZHOU Jun; WANG Zhi; ZHOU Feng-qi

    2007-01-01

    The nonlinear dynamic model of spinning ballistic missiles is established during the first boosting phase of the missile. Based on the conventional backstepping sliding mode control and the assumption of a two time-scale separation of missile dynamics, a graded sliding mode controller is designed with two sub-sliding surfaces which have invariability to external disturbances and parameter perturbations, and a matrix which comprises three first order low pass filters is introduced to prevent "explosion of terms". Owing to the upper bounds of the uncertainties are difficult to obtain in advance,adaptive laws are introduced to estimate the values of the uncertainties in real-time. Eventually, the numerical simulation results given to show the proposed controller can ensure the steady flight of missiles.

  4. Radar signal analysis of ballistic missile with micro-motion based on time-frequency distribution

    Science.gov (United States)

    Wang, Jianming; Liu, Lihua; Yu, Hua

    2015-12-01

    The micro-motion of ballistic missile targets induces micro-Doppler modulation on the radar return signal, which is a unique feature for the warhead discrimination during flight. In order to extract the micro-Doppler feature of ballistic missile targets, time-frequency analysis is employed to process the micro-Doppler modulated time-varying radar signal. The images of time-frequency distribution (TFD) reveal the micro-Doppler modulation characteristic very well. However, there are many existing time-frequency analysis methods to generate the time-frequency distribution images, including the short-time Fourier transform (STFT), Wigner distribution (WD) and Cohen class distribution, etc. Under the background of ballistic missile defence, the paper aims at working out an effective time-frequency analysis method for ballistic missile warhead discrimination from the decoys.

  5. A Terminal Guidance Law Based on Motion Camouflage Strategy of Air-to-Ground Missiles

    Directory of Open Access Journals (Sweden)

    Chang-sheng Gao

    2016-01-01

    Full Text Available A guidance law for attacking ground target based on motion camouflage strategy is proposed in this paper. According to the relative position between missile and target, the dual second-order dynamics model is derived. The missile guidance condition is given by analyzing the characteristic of motion camouflage strategy. Then, the terminal guidance law is derived by using the relative motion of missile and target and the guidance condition. In the process of derivation, the three-dimensional guidance law could be designed in a two-dimensional plane and the difficulty of guidance law design is reduced. A two-dimensional guidance law for three-dimensional space is derived by bringing the estimation for target maneuver. Finally, simulation for the proposed guidance law is taken and compared with pure proportional navigation. The simulation results demonstrate that the proposed guidance law can be applied to air-to-ground missiles.

  6. Missile injuries to the external genitalia: a five year experience in Maiduguri, North Eastern Nigeria

    Directory of Open Access Journals (Sweden)

    Hassan Mohammed Dogo

    2016-07-01

    Conclusions: Genital missile injuries are on the increase with militarization of civilian population. Goals of treatment still remain cosmesis, preservation of erectile and voiding function. [Int J Res Med Sci 2016; 4(7.000: 2964-2966

  7. New reduced volume preparation regimen in colon capsule endoscopy

    Institute of Scientific and Technical Information of China (English)

    Yasuo Kakugawa; Kazuhide Higuchi; Shinji Tanaka; Hideki Ishikawa; Hisao Tajiri; Yutaka Saito; Shoichi Saito; Kenji Watanabe; Naoki Ohmiya; Mitsuyuki Murano; Shiro Oka; Tetsuo Arakawa; Hidemi Goto

    2012-01-01

    AIM:To evaluate the effectiveness of our proposed bowel preparation method for colon capsule endoscopy.METHODS:A pilot,multicenter,randomized controlled trial compared our proposed "reduced volume method" (group A) with the "conventional volume method" (group B) preparation regimens.Group A did not drink polyethylene glycol electrolyte lavage solution (PEGELS) the day before the capsule procedure,while group B drank 2 L.During the procedure day,groups A and B drank 2 L and 1 L of PEG-ELS,respectively,and swallowed the colon capsule (PillCam COLON(R) capsule).Two hours later the first booster of 100 g magnesium citrate mixed with 900 mL water was administered to both groups,and the second booster was administered six hours post capsule ingestion as long as the capsule had not been excreted by that time.Capsule videos were reviewed for grading of cleansing level.RESULTS:Sixty-four subjects were enrolled,with results from 60 analyzed.Groups A and B included 31 and 29 subjects,respectively.Twenty-nine (94%) subjects in group A and 25 (86%) subjects in group B had adequate bowel preparation (ns).Twenty-two (71%) of the 31 subjects in group A excreted the capsule within its battery life compared to 16 (55%) of the 29 subjects in group B (ns).Of the remaining 22 subjects whose capsules were not excreted within the battery life,all of the capsules reached the left side colon before they stopped functioning.A single adverse event was reported in one subject who had mild symptoms of nausea and vomiting one hour after starting to drink PEG-ELS,due to ingesting the PEG-ELS faster than recommended.CONCLUSION:Our proposed reduced volume bowel preparation method for colon capsule without PEG-ELS during the days before the procedure was as effective as the conventional volume method.

  8. Seeing 2020: America’s New Vision for Integrated Air and Missile Defense

    Science.gov (United States)

    2015-01-01

    the U.S. Army Air Corps began Operation Crossbow, the Anglo-American bombing campaign against Adolf Hitler’s V-1 and V-2 missile forces and a...science of war and its weapons matured, the development of improved propulsion, guidance, and payloads in guns, artillery, rockets, mortars , aircraft...range of threats to include short- and intermediate-range ballistic missiles, bombers, and tactical weapons such as artillery, rockets, and mortars

  9. Missile Captive Carry Monitoring and Helicopter Identification Using a Capacitive Microelectromechanical Systems Accelerometer

    Energy Technology Data Exchange (ETDEWEB)

    Hatchell, Brian K.; Mauss, Fredrick J.; Amaya, Ivan A.; Skorpik, James R.; Silvers, Kurt L.; Marotta, Steve

    2012-03-27

    Military missiles are exposed to many sources of mechanical vibration that can affect system reliability, safety, and mission effectiveness. The U. S. Army Aviation and Missile Research Development and Engineering Center (AMRDEC) has been developing missile health monitoring systems to assess and improve reliability, reduce life cycle costs, and increase system readiness. One of the most significant exposures to vibration occurs when the missile is being carried by a helicopter or other aviation platform, which is a condition known as captive carry. Recording the duration of captive carry exposure during the missile’s service life can enable the implementation of predictive maintenance and resource management programs. Since the vibration imparted by each class of helicopter varies in frequency and amplitude, tracking the vibration exposure from each helicopter separately can help quantify the severity and harmonic content of the exposure. Under the direction of AMRDEC staff, engineers at the Pacific Northwest National Laboratory have developed a Captive Carry Health Monitor (CCHM) for the Hellfire II missile. The CCHM is an embedded usage monitoring device installed on the outer skin of the Hellfire II missile to record the cumulative hours the host missile has been in captive carry mode. To classify the vibration by class of helicopter, the CCHM analyzes the amplitude and frequency content of the vibration with the Goertzel algorithm to detect the presence of distinctive rotor harmonics. Cumulative usage data are accessible in theater from an external display; monthly usage histograms are accessible through an internal download connector. This paper provides an overview of the CCHM electrical and package design, describes field testing and data analysis techniques used to monitor captive carry identify and the class of helicopter, and discusses the potential application of missile health and usage data for real-time reliability analysis and fleet management.

  10. Steady Fault Characteristic Analysis of a Missile Power System Based on a Differential Evolution Algorithm

    Institute of Scientific and Technical Information of China (English)

    XU Zhi-gao; GUAN Zheng-xi; MA Jing

    2005-01-01

    The differential evolution (DE) algorithm is applied to solving the models' equations of a whole missile power system, and the steady fault characteristics of the whole system are analyzed. The DE algorithm is robust, requires few control variables, is easy to use and lends itself very well to parallel computation. Calculation results indicate that the DE algorithm simulates faults of a missile power system very well.

  11. Six-Degree-of-Freedom Digital Simulations for Missile Guidance and Control

    Directory of Open Access Journals (Sweden)

    Yongjie Xu

    2015-01-01

    Full Text Available Six-degree-of-freedom ballistic trajectory model can be used to verify design indicators, performance parameters, and correctness so they have been put forward in the missile argumentation and design process. Mathematical simulation is the basis of late semiphysical simulation and field firing testing, and it can greatly reduce the field shooting test time, which shortens the missile test cycle and so reduces costs.

  12. Defense Science Board Task Force on Defense Strategies for Advanced Ballistic and Cruise Missile Threats

    Science.gov (United States)

    2017-01-01

    REPORT OF THE DEFENSE SCIENCE BOARD TASK FORCE ON Defense Strategies for Advanced Ballistic and Cruise Missile Threats January 2017 Office of... Science Board (DSB). The DSB is a Federal Advisory Committee established to provide independent advice to the Secretary of Defense. Statements, opinions... Science Board Task Force on Defense Strategies for Advanced Ballistic and Cruise Missile Threats completed its information-gathering in February 2016

  13. The Impact on Strategic Stability of Ballistic Missile Defense in Eastern Europe

    Science.gov (United States)

    2009-06-12

    the final chapter of the Eastern European missile defense saga has yet to be written, this study can contribute to the field of knowledge even at...Canada at the USSR Academy of Sciences. This publication is invaluable in examining how strategic stability was viewed at the twilight of the Cold...the Czech Republic are carrying out deliberations and how Russia is reacting to each particular new wrinkle in the missile defense saga ; and

  14. A Strategic Conversation about National Missile Defense (Strategic Studies Quarterly, Winter 2008)

    Science.gov (United States)

    2008-01-01

    they were “producing missiles like sausages .” These quotes, and the overall tone of Reagan’s speech, indicate the specific historical context in which...in this article . LeFevre.indd 108 10/30/08 1:18:22 PM A Strategic Conversation about National Missile Defense Strategic  Studies  Quarterly...time.com/time/magazine/ article /0,9171,923443,00.html. 3. National Intelligence Council, “Iran: Nuclear Intentions and Capabilities,” National Intel- ligence

  15. 21 CFR 876.1300 - Ingestible telemetric gastrointestinal capsule imaging system.

    Science.gov (United States)

    2010-04-01

    ... § 876.1300 Ingestible telemetric gastrointestinal capsule imaging system. (a) Identification. An ingestible telemetric gastrointestinal capsule imaging system is used for visualization of the small bowel... Special Controls Guidance Document: Ingestible Telemetric Gastrointestinal Capsule Imaging Systems;...

  16. Potassium iodide capsule treatment of feline sporotrichosis.

    Science.gov (United States)

    Reis, Erica G; Gremião, Isabella D F; Kitada, Amanda A B; Rocha, Raphael F D B; Castro, Verônica S P; Barros, Mônica B L; Menezes, Rodrigo C; Pereira, Sandro A; Schubach, Tânia M P

    2012-06-01

    Sporotrichosis is a mycosis caused by Sporothrix schenckii. The most affected animal is the cat; it has played an important role in the zoonotic transmission of this disease, especially in Rio de Janeiro, Brazil, since 1998. In order to evaluate the treatment of feline sporotrichosis with potassium iodide, an observational cohort was conducted in 48 cats with sporotrichosis at Instituto de Pesquisa Clínica Evandro Chagas, Fiocruz. All cats received potassium iodide capsules, 2.5 mg/kg to 20 mg/kg q24h. The cure rate was 47.9%, treatment failure was 37.5%, treatment abandonment was 10.4% and death was 4.2%. Clinical adverse effects were observed in 52.1% of the cases. Thirteen cats had a mild increase in hepatic transaminase levels during the treatment, six of them presented clinical signs suggestive of hepatotoxicity. Compared to previous studies with itraconazole and iodide in saturated solution, potassium iodide capsules are an alternative for feline sporotrichosis treatment.

  17. Orbital Thermal Control of the Mercury Capsule

    Science.gov (United States)

    Weston, Kenneth C.

    1960-01-01

    The approach to orbital thermal control of the Project Mercury capsule environment is relatively unsophisticated compared with that for many unmanned satellites. This is made possible by the relatively short orbital flight of about 4 1/2 hours and by the presence of the astronaut who is able to monitor the capsule systems and compensate for undesirable thermal conditions. The general external features of the Mercury configuration as it appears in the orbital phase of flight are shown. The conical afterbody is a double-wall structure. The inner wall serves as a pressure vessel for the manned compartment, and the outer wall, of shingle type construction, acts as a radiating shield during reentry. Surface treatment of the shingles calls for a stably oxidized surface to minimize reentry temperatures. The shingles are supported by insulated stringers attached to the inner skin. Areas between stringers are insulated by blankets of Thermoflex insulation. This insulation is especially effective at high altitude due to the reduction of its thermal conductivity with decreasing pressure. As a result of the design of the afterbody for the severe reentry conditions, the heat balance on the manned compartment indicates the necessity for moderate internal cooling to compensate for the heat generation due to human and electrical sources. This cooling is achieved by the controlled vaporization of water in the cabin and astronaut-suit heat exchangers.

  18. Posterior capsule opacification. Part 1: Experimental investigations.

    Science.gov (United States)

    Nishi, O

    1999-01-01

    Posterior capsule opacification (PCO) is the most frequent complication associated with decreased vision after cataract surgery. Previous methods of preventing PCO have not proven to be practical, effective, and safe for routine clinical procedure, but some novel concepts and methods have recently been developed. This 2-part review looks at clinical and experimental investigations of PCO, focusing on developments since 1992. Clinical aspects will be presented in a later issue. This paper addresses (1) in vitro models for PCO research; (2) pathophysiology and molecular biology of lens epithelial cells (LECs); (3) prevention of PCO. Of special interest are methods of culturing human LECs obtained by capsulotomy during cataract surgery, including those obtained with an intact capsular bag, to provide an in vitro model for investigating the pathophysiology of LECs; the effect of a sharp bend in the lens capsule that induces contact inhibition of migrating LECs; more specific inhibition of migrating LECs using an immunotoxin, b-FGF-saporin, or EDTA and RGD-peptides.

  19. Potential value of Cs-137 capsules

    Energy Technology Data Exchange (ETDEWEB)

    Bloomster, C.H.; Brown, D.R.; Bruno, G.A.; Hazelton, R.F.; Hendrickson, P.L.; Lezberg, A.J.; Tingey, G.L.; Wilfert, G.L.

    1985-04-01

    We determined the value of Cs-137 compared to Co-60 as a source for the irradiation of fruit (apples and cherries), pork and medical supplies. Cs-137, in the WESF capsule form, had a value of approximately $0.40/Ci as a substitute for Co-60 priced at approximately $1.00/Ci. The comparison was based on the available curies emitted from the surface of each capsule. We developed preliminary designs for fourteen irradiation facilities; seven were based on Co-60 and seven were based on Cs-137. These designs provided the basis for estimating capital and operating costs which, in turn, provided the basis for determining the value of Cs-137 relative to Co-60 in these applications. We evaluated the effect of the size of the irradiation facility on the value of Cs-137. The cost of irradiation is low compared to the value of the product. Irradiation of apples for disinfestation costs $.01 to .02 per pound. Irradiation for trichina-safe pork costs $.02 per pound. Irradiation of medical supplies for sterilization costs $.07 to .12 per pound. The cost of the irradiation source, either Co-60 or Cs-137, contributed only a minor amount to the total cost of irradiation, about 5% for the fruit and hog cases and about 20% for the medical supply cases. We analyzed the sensitivity of the irradiation costs and Cs-137 value to several key assumptions.

  20. Isotretinoin Oil-Based Capsule Formulation Optimization

    Directory of Open Access Journals (Sweden)

    Pi-Ju Tsai

    2013-01-01

    Full Text Available The purpose of this study was to develop and optimize an isotretinoin oil-based capsule with specific dissolution pattern. A three-factor-constrained mixture design was used to prepare the systemic model formulations. The independent factors were the components of oil-based capsule including beeswax (X1, hydrogenated coconut oil (X2, and soybean oil (X3. The drug release percentages at 10, 30, 60, and 90 min were selected as responses. The effect of formulation factors including that on responses was inspected by using response surface methodology (RSM. Multiple-response optimization was performed to search for the appropriate formulation with specific release pattern. It was found that the interaction effect of these formulation factors (X1X2, X1X3, and X2X3 showed more potential influence than that of the main factors (X1, X2, and X3. An optimal predicted formulation with Y10 min, Y30 min, Y60 min, and Y90 min release values of 12.3%, 36.7%, 73.6%, and 92.7% at X1, X2, and X3 of 5.75, 15.37, and 78.88, respectively, was developed. The new formulation was prepared and performed by the dissolution test. The similarity factor f2 was 54.8, indicating that the dissolution pattern of the new optimized formulation showed equivalence to the predicted profile.

  1. Quality evaluation of simvastatin compounded capsules

    Directory of Open Access Journals (Sweden)

    Flávia Dias Marques-Marinho

    2011-09-01

    Full Text Available Simvastatin is commercially available as tablets and compounded capsules in Brazil. Very few reports regarding these capsules' quality, and consequently their efficacy, are available. The pharmaceutical quality of 30 batches of 20 mg simvastatin capsules from the market was evaluated by weight determination, content uniformity, disintegration (Brazilian Pharmacopeia, assay and dissolution test (USP32 tablet monograph. A HPLC method was developed for assay, content uniformity and dissolution test, and specifications were also established. Out of the 30 batches evaluated, 29 showed capsule disintegration within 45 min and individual weight variation was within ±10% or ±7.5% relative to average weight, for 300 mg, respectively. Only 27 batches met dissolution test criteria with values >80% of the labeled amount in 45 min; 21 batches showed simvastatin content between 90.0-110.0% of the labeled amount and 19 batches had at least 9 out of 10 capsules with content uniformity values between 85.0-115.0% of the labeled amount with RSDNo Brasil, a sinvastatina está comercialmente disponível na forma de comprimidos e cápsulas manipuladas. Poucos relatos estão disponíveis sobre a qualidade e, consequentemente, a eficácia dessas cápsulas. A qualidade de 30 lotes de sinvastatina 20 mg cápsulas do mercado foi avaliada através da determinação de peso, uniformidade de conteúdo, desintegração (Farmacopéia Brasileira, doseamento e teste de dissolução (monografia comprimidos USP32. Método por CLAE foi desenvolvido para o doseamento, uniformidade de conteúdo e teste de dissolução; além disso, especificações foram estabelecidas. Dos 30 lotes avaliados, 29 apresentaram desintegração da cápsula até 45 min e a variação do peso individual foi ± 10% ou ± 7,5% em relação ao peso médio, se 300 mg, respectivamente. Apenas 27 lotes preencheram os critérios do teste de dissolução com valores > 80% da quantidade rotulada, em 45 min, 21

  2. Cooperative Monitoring Center Occasional Paper/9: De-Alerting Strategic Ballistic Missiles

    Energy Technology Data Exchange (ETDEWEB)

    Connell, Leonard W.; Edenburn, Michael W.; Fraley, Stanley K.; Trost, Lawrence C.

    1999-03-01

    This paper presents a framework for evaluating the technical merits of strategic ballistic missile de-alerting measures, and it uses the framework to evaluate a variety of possible measures for silo-based, land-mobile, and submarine-based missiles. De-alerting measures are defined for the purpose of this paper as reversible actions taken to increase the time or effort required to launch a strategic ballistic missile. The paper does not assess the desirability of pursuing a de-alerting program. Such an assessment is highly context dependent. The paper postulates that if de-alerting is desirable and is used as an arms control mechanism, de-alerting measures should satisfy specific cirteria relating to force security, practicality, effectiveness, significant delay, and verifiability. Silo-launched missiles lend themselves most readily to de-alerting verification, because communications necessary for monitoring do not increase the vulnerabilty of the weapons by a significant amount. Land-mobile missile de-alerting measures would be more challenging to verify, because monitoring measures that disclose the launcher's location would potentially increase their vulnerability. Submarine-launched missile de-alerting measures would be extremely challlenging if not impossible to monitor without increasing the submarine's vulnerability.

  3. Countermeasure effectiveness against an intelligent imaging infrared anti-ship missile

    Science.gov (United States)

    Gray, Greer J.; Aouf, Nabil; Richardson, Mark; Butters, Brian; Walmsley, Roy

    2013-02-01

    Ship self defense against heat-seeking anti-ship missiles is of great concern to modern naval forces. One way of protecting ships against these threats is to use infrared (IR) offboard countermeasures. These decoys need precise placement to maximize their effectiveness, and simulation is an invaluable tool used in determining optimum deployment strategies. To perform useful simulations, high-fidelity models of missiles are required. We describe the development of an imaging IR anti-ship missile model for use in countermeasure effectiveness simulations. The missile model's tracking algorithm is based on a target recognition system that uses a neural network to discriminate between ships and decoys. The neural network is trained on shape- and intensity-based features extracted from simulated imagery. The missile model is then used within ship-decoy-missile engagement simulations, to determine how susceptible it is to the well-known walk-off seduction countermeasure technique. Finally, ship survivability is improved by adjusting the decoy model to increase its effectiveness against the tracker.

  4. Triple-ion interactions for the construction of supramolecular capsules

    NARCIS (Netherlands)

    Oshovsky, G.; Reinhoudt, David; Verboom, Willem

    2006-01-01

    A novel type of [2+4] capsules based on triple-ion interactions was obtained. Four monovalent anions (bromide, nitrate, acetate, and tosylate) bring together two tetrakis(pyridiniummethyl)tetramethyl cavitands by pyridinium−anion−pyridinium interactions. ESI-MS experiments have confirmed the capsule

  5. Experimental measurement on movement of spiral-type capsule endoscope

    Directory of Open Access Journals (Sweden)

    Yang W

    2016-01-01

    Full Text Available Wanan Yang,1 Houde Dai,2 Yong He,1 Fengqing Qin1 1School of Computer and Information Engineering, Yibin University, Yibin, Sichuan, People's Republic of China; 2Quanzhou Institute of Equipment Manufacturing, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Quanzhou, People's Republic of China Abstract: Wireless capsule endoscope achieved great success, however, the maneuvering of wireless capsule endoscope is challenging at present. A magnetic driving instrument, including two bar magnets, a stepper motor, a motor driver, a motor controller, and a power supplier, was developed to generate rotational magnetic fields. Permanent magnet ring, magnetized as S and N poles radially and mounted spiral structure on the surface, acted as a capsule. The maximum torque passing to the capsule, rotational synchronization of capsule and motor, and the translational speed of capsule, were measured in ex vivo porcine large intestine. The experimental results illustrate that the rotational movement of the spiral-type capsule in the intestine is feasible and the cost of the magnetic driving equipment is low. As a result, the solution is promising in the future controllability. Keywords: wireless capsule endoscope, magnet ring, magnetic driving, spiral structure, torque  

  6. Improving ICF implosion performance with alternative capsule supports

    Science.gov (United States)

    Weber, C. R.; Casey, D. T.; Clark, D. S.; Hammel, B. A.; MacPhee, A.; Milovich, J.; Martinez, D.; Robey, H. F.; Smalyuk, V. A.; Stadermann, M.; Amendt, P.; Bhandarkar, S.; Chang, B.; Choate, C.; Crippen, J.; Felker, S. J.; Field, J. E.; Haan, S. W.; Johnson, S.; Kroll, J. J.; Landen, O. L.; Marinak, M.; Mcinnis, M.; Nikroo, A.; Rice, N.; Sepke, S. M.

    2017-05-01

    The thin membrane that holds the capsule in-place in the hohlraum is recognized as one of the most significant contributors to reduced performance in indirect drive inertial confinement fusion (ICF) experiments on the National Ignition Facility. This membrane, known as the "tent," seeds a perturbation that is amplified by Rayleigh-Taylor and can rupture the capsule. A less damaging capsule support mechanism is under development. Possible alternatives include the micron-scale rods spanning the hohlraum width and supporting either the capsule or stiffening the fill-tube, a larger fill-tube to both fill and support the capsule, or a low-density foam layer that protects the capsule from the tent impact. Experiments are testing these support features to measure their imprint on the capsule. These experiments are revealing unexpected aspects about perturbation development in indirect drive ICF, such as the importance of shadows coming from bright spots in the hohlraum. Two dimensional and 3D models are used to explain these features and assess the impact on implosion performance. Experiments and modeling suggest that the fill-tube supported by a perpendicular rod can mount the capsule without any additional perturbation beyond that of the fill tube.

  7. Risk factors for incomplete small-bowel capsule endoscopy

    NARCIS (Netherlands)

    Westerhof, Jessie; Weersma, Rinse K.; Koornstra, Jan J.

    2009-01-01

    Background: In 20% to 30% of capsule endoscopy (CE) procedures, the capsule does not reach the cecum within recording time, with incomplete imaging of the small bowel, which limits the value of CE. Objective: To identify possible risk factors for incomplete small-bowel CE examinations. Design: Data

  8. Material properties of the human posterior knee capsule

    NARCIS (Netherlands)

    Rachmat, H.H.; Janssen, D.W.; van Tienen, T.; Diercks, R.L.; Verkerke, Gijsbertus Jacob; Verdonschot, Nicolaas Jacobus Joseph; Fernandes, Paulo; Folgado, Joao; Silva, Miguel

    2012-01-01

    BACKGROUND: There is considerable interest to develop accurate subject-specific biomechanical models of the knee. Most of the existing models currently do not include a representation of the posterior knee capsule. In order to incorporate the posterior capsule in knee models, data is needed on its

  9. Experimental modulation of capsule size in Cryptococcus neoformans

    Directory of Open Access Journals (Sweden)

    Zaragoza Oscar

    2004-01-01

    Full Text Available Experimental modulation of capsule size is an important technique for the study of the virulence of the encapsulated pathogen Cryptococcus neoformans. In this paper, we summarize the techniques available for experimental modulation of capsule size in this yeast and describe improved methods to induce capsule size changes. The response of the yeast to the various stimuli is highly dependent on the cryptococcal strain. A high CO2 atmosphere and a low iron concentration have been used classically to increase capsule size. Unfortunately, these stimuli are not reliable for inducing capsular enlargement in all strains. Recently we have identified new and simpler conditions for inducing capsule enlargement that consistently elicited this effect. Specifically, we noted that mammalian serum or diluted Sabouraud broth in MOPS buffer pH 7.3 efficiently induced capsule growth. Media that slowed the growth rate of the yeast correlated with an increase in capsule size. Finally, we summarize the most commonly used media that induce capsule growth in C. neoformans.

  10. Analysis of Fission Products on the AGR-1 Capsule Components

    Energy Technology Data Exchange (ETDEWEB)

    Paul A. Demkowicz; Jason M. Harp; Philip L. Winston; Scott A. Ploger

    2013-03-01

    The components of the AGR-1 irradiation capsules were analyzed to determine the retained inventory of fission products in order to determine the extent of in-pile fission product release from the fuel compacts. This includes analysis of (i) the metal capsule components, (ii) the graphite fuel holders, (iii) the graphite spacers, and (iv) the gas exit lines. The fission products most prevalent in the components were Ag-110m, Cs 134, Cs 137, Eu-154, and Sr 90, and the most common location was the metal capsule components and the graphite fuel holders. Gamma scanning of the graphite fuel holders was also performed to determine spatial distribution of Ag-110m and radiocesium. Silver was released from the fuel components in significant fractions. The total Ag-110m inventory found in the capsules ranged from 1.2×10 2 (Capsule 3) to 3.8×10 1 (Capsule 6). Ag-110m was not distributed evenly in the graphite fuel holders, but tended to concentrate at the axial ends of the graphite holders in Capsules 1 and 6 (located at the top and bottom of the test train) and near the axial center in Capsules 2, 3, and 5 (in the center of the test train). The Ag-110m further tended to be concentrated around fuel stacks 1 and 3, the two stacks facing the ATR reactor core and location of higher burnup, neutron fluence, and temperatures compared with Stack 2. Detailed correlation of silver release with fuel type and irradiation temperatures is problematic at the capsule level due to the large range of temperatures experienced by individual fuel compacts in each capsule. A comprehensive Ag 110m mass balance for the capsules was performed using measured inventories of individual compacts and the inventory on the capsule components. For most capsules, the mass balance was within 11% of the predicted inventory. The Ag-110m release from individual compacts often exhibited a very large range within a particular capsule.

  11. Analysis of Fission Products on the AGR-1 Capsule Components

    Energy Technology Data Exchange (ETDEWEB)

    Paul A. Demkowicz; Jason M. Harp; Philip L. Winston; Scott A. Ploger

    2013-03-01

    The components of the AGR-1 irradiation capsules were analyzed to determine the retained inventory of fission products in order to determine the extent of in-pile fission product release from the fuel compacts. This includes analysis of (i) the metal capsule components, (ii) the graphite fuel holders, (iii) the graphite spacers, and (iv) the gas exit lines. The fission products most prevalent in the components were Ag-110m, Cs 134, Cs 137, Eu-154, and Sr 90, and the most common location was the metal capsule components and the graphite fuel holders. Gamma scanning of the graphite fuel holders was also performed to determine spatial distribution of Ag-110m and radiocesium. Silver was released from the fuel components in significant fractions. The total Ag-110m inventory found in the capsules ranged from 1.2×10 2 (Capsule 3) to 3.8×10 1 (Capsule 6). Ag-110m was not distributed evenly in the graphite fuel holders, but tended to concentrate at the axial ends of the graphite holders in Capsules 1 and 6 (located at the top and bottom of the test train) and near the axial center in Capsules 2, 3, and 5 (in the center of the test train). The Ag-110m further tended to be concentrated around fuel stacks 1 and 3, the two stacks facing the ATR reactor core and location of higher burnup, neutron fluence, and temperatures compared with Stack 2. Detailed correlation of silver release with fuel type and irradiation temperatures is problematic at the capsule level due to the large range of temperatures experienced by individual fuel compacts in each capsule. A comprehensive Ag 110m mass balance for the capsules was performed using measured inventories of individual compacts and the inventory on the capsule components. For most capsules, the mass balance was within 11% of the predicted inventory. The Ag-110m release from individual compacts often exhibited a very large range within a particular capsule.

  12. Analysing intracellular deformation of polymer capsules using structured illumination microscopy

    Science.gov (United States)

    Chen, Xi; Cui, Jiwei; Sun, Huanli; Müllner, Markus; Yan, Yan; Noi, Ka Fung; Ping, Yuan; Caruso, Frank

    2016-06-01

    Understanding the behaviour of therapeutic carriers is important in elucidating their mechanism of action and how they are processed inside cells. Herein we examine the intracellular deformation of layer-by-layer assembled polymer capsules using super-resolution structured illumination microscopy (SIM). Spherical- and cylindrical-shaped capsules were studied in three different cell lines, namely HeLa (human epithelial cell line), RAW264.7 (mouse macrophage cell line) and differentiated THP-1 (human monocyte-derived macrophage cell line). We observed that the deformation of capsules was dependent on cell line, but independent of capsule shape. This suggests that the mechanical forces, which induce capsule deformation during cell uptake, vary between cell lines, indicating that the capsules are exposed to higher mechanical forces in HeLa cells, followed by RAW264.7 and then differentiated THP-1 cells. Our study demonstrates the use of super-resolution SIM in analysing intracellular capsule deformation, offering important insights into the cellular processing of drug carriers in cells and providing fundamental knowledge of intracellular mechanobiology. Furthermore, this study may aid in the design of novel drug carriers that are sensitive to deformation for enhanced drug release properties.Understanding the behaviour of therapeutic carriers is important in elucidating their mechanism of action and how they are processed inside cells. Herein we examine the intracellular deformation of layer-by-layer assembled polymer capsules using super-resolution structured illumination microscopy (SIM). Spherical- and cylindrical-shaped capsules were studied in three different cell lines, namely HeLa (human epithelial cell line), RAW264.7 (mouse macrophage cell line) and differentiated THP-1 (human monocyte-derived macrophage cell line). We observed that the deformation of capsules was dependent on cell line, but independent of capsule shape. This suggests that the mechanical forces

  13. Surgical treatment of tibial nonunion after wounding by high velocity missile and external fixators: A case report

    OpenAIRE

    2012-01-01

    Introduction. The missiles of modern firearms can cause severe fractures of the extremity. High velocity missile fractures of the tibia are characterized by massive tissue destruction and primary contamination with polymorphic bacteria. Treatment of these fractures is often complicated by delayed healing, poor position healing, nonhealing and bone tissue infection. Case Outline. We present the management of tibial nonunion after wounding by high velocity missile and primary treatment by...

  14. RAMA Surveillance Capsule and Component Activation Analyses

    Energy Technology Data Exchange (ETDEWEB)

    Watkins, Kenneth E.; Jones, Eric N. [TransWare Enterprises Inc., 1565 Mediterranean Dr., Sycamore, IL 60178 (United States); Carter, Robert G. [Electric Power Research Institute, 1300 West W. T. Harris Blvd., Charlotte, NC 28262 (United States)

    2011-07-01

    This paper presents the calculated-to-measured ratios associated with the application of the RAMA Fluence Methodology software to light water reactor surveillance capsule and reactor component activation evaluations. Comparisons to measurements are performed for pressurized water reactor and boiling water reactor surveillance capsule activity specimens from seventeen operating light water reactors. Comparisons to measurements are also performed for samples removed from the core shroud, top guide, and jet pump brace pads from two reactors. In conclusion: The flexible geometry modeling capabilities provided by RAMA, combined with the detailed representation of operating reactor history and anisotropic scattering detail, produces accurate predictions of the fast neutron fluence and neutron activation for BWR and PWR surveillance capsule geometries. This allows best estimate RPV fluence to be determined without the need for multiplicative bias corrections. The three-dimensional modeling capability in RAMA provides an accurate estimate of the fast neutron fluence for regions far removed from the core mid-plane elevation. The comparisons to activation measurements for various core components indicate that the RAMA predictions are reasonable, and notably conservative (i.e., C/M ratios are consistently greater than unity). It should be noted that in the current evaluations, the top and bottom fuel regions are represented by six inch height nodes. As a result, the leakage-induced decrease in power near the upper and lower edges of the core are not well represented in the current models. More precise predictions of fluence for components that lie above and below the core boundaries could be obtained if the upper and lower fuel nodes were subdivided into multiple axial regions with assigned powers that reflect the neutron leakage at the top and bottom of the core. This use of additional axial sub-meshing at the top and bottom of the core is analogous to the use of pin

  15. Optimal Bowel Preparation for Video Capsule Endoscopy

    Directory of Open Access Journals (Sweden)

    Hyun Joo Song

    2016-01-01

    Full Text Available During video capsule endoscopy (VCE, several factors, such as air bubbles, food material in the small bowel, and delayed gastric and small bowel transit time, influence diagnostic yield, small bowel visualization quality, and cecal completion rate. Therefore, bowel preparation before VCE is as essential as bowel preparation before colonoscopy. To date, there have been many comparative studies, consensus, and guidelines regarding different kinds of bowel cleansing agents in bowel preparation for small bowel VCE. Presently, polyethylene glycol- (PEG- based regimens are given primary recommendation. Sodium picosulphate-based regimens are secondarily recommended, as their cleansing efficacy is less than that of PEG-based regimens. Sodium phosphate as well as complementary simethicone and prokinetics use are considered. In this paper, we reviewed previous studies regarding bowel preparation for small bowel VCE and suggested optimal bowel preparation of VCE.

  16. Vortex Rings from Sphagnum Moss Capsules

    CERN Document Server

    Chang, Emily S; Cha, Jung Ha; Strassman, Sam; Hard, Clara; Whitaker, Dwight L

    2010-01-01

    Long distance wind dispersal requires small spores with low terminal velocities, which can be held aloft by turbulent air currents until they are deposited in suitable habitats for colonization. The inherent difficulty in dispersing spores by wind is that spores easily carried by wind are also rapidly decelerated when moving through still air. Thus the height of spore release is critical in determining their range of dispersal. Vascular plants with wind dispersed spores use the height of the plant to lift spores into sufficient wind currents for dispersal, however non-vascular plants such as Sphagnum cannot grow sufficiently tall. These fluid dynamics videos show how exploding capsules of {\\em Sphagnum} moss generate vortex rings to carry spores to heights above 10 cm with an initial velocity of 16 m s$^{-1}$. In contrast spores launched ballistically at these speeds through still air would travel only 2-7 mm.

  17. A comparative study on liquid core formulation on the diameter on the alginate capsules

    Science.gov (United States)

    Ong, Hui-Yen; Lee, Boon-Beng; Radzi, AkmalHadi Ma'; Zakaria, Zarina; Chan, Eng-Seng

    2015-08-01

    Liquid core capsule has vast application in biotechnology related industries such as pharmaceutical, medical, agriculture and food. Formulation of different types of capsule was important to determine the performance of the capsule. Generally, the liquid core capsule with different formulations generated different size of capsule.Therefore, the aim of this project is to investigate the effect of different liquid core solution formulations on the diameter of capsule. The capsule produced by extruding liquid core solutions into sodium alginate solution. Three types of liquid core solutions (chitosan, xanthan gum, polyethylene glycol (PEG)) were investigated. The results showed that there is significant change in capsule diameter despite in different types of liquid core solution were used and a series of capsule range in diameter of 3.1 mm to 4.5 mm were produced. Alginate capsule with chitosan formulation appeared to be the largest capsule among all.

  18. In vitro study on sustained release capsule formulation of acetazolamide.

    Science.gov (United States)

    Pandey, V P; Kannan, K; Manavalan, R; Desai, N

    2003-10-01

    In the present study formulation of sustained release capsule of acetazolamide 250 mg was tried using nonpareil seeds. Nonpareil seeds were coated with drug, polyvinylpyrrolidone, glyceryl monostearate, microcrystalline wax, and glyceryl distearate either individually or in combination to achieve sustained release capsule 250 mg. In successful formulation 20% drug coated pellets and 80% wax coated pellets were taken. Wax coated pellets for successful formulation contained coating of microcrystalline wax and glyceryl distearate on drug coated pellets of the same concentration of 1.6% w/w. Successful formulated sustained release capsule 250 mg of acetazolamide was compared in in vitro study with theoretical sustained release formulation suggested by wagner and one marketed sustained release capsule 250 mg. Formulated capsule showed result superior to or on par with marketed capsule. For successful formulation pellets were filled in '1' size hard gelatin capsule and stability study was carried out in hot air over at room temperature and 45 degrees C for 5 weeks. The formulation was found stable in respect of drug content and release rate.

  19. Tuning the Properties of Polymer Capsules for Cellular Interactions.

    Science.gov (United States)

    Sun, Huanli; Cui, Jiwei; Ju, Yi; Chen, Xi; Wong, Edgar H H; Tran, Jenny; Qiao, Greg G; Caruso, Frank

    2017-07-19

    Particle-cell interactions are governed by, among other factors, the composition and surface properties of the particles. Herein, we report the preparation of various polymer capsules with different compositions and properties via atom transfer radical polymerization mediated continuous assembly of polymers (CAPATRP), where the cellular interactions of these capsules, particularly fouling and specific targeting, are examined by flow cytometry and deconvolution microscopy. Acrylated eight-arm poly(ethylene glycol) (8-PEG) and poly(N-(2-hydroxypropyl)-methacrylamide) (PHPMA) as well as methacrylated hyaluronic acid (HA), poly(glutamic acid) (PGA), and poly(methacrylic acid) (PMA) are used as macro-cross-linkers to obtain a range of polymer capsules with different compositions (PEG, PHPMA, HA, PGA, and PMA). Capsules composed of low-fouling polymers, PEG and PHPMA, show negligible association with macrophage Raw 264.7, monocyte THP-1, and HeLa cells. HA capsules, although moderately low-fouling (capsules show high cellular association toward phagocytic Raw 264.7 and THP-1 cells. These findings demonstrate the capability of the CAPATRP technique in preparing polymer capsules with specific cellular interactions.

  20. Albumin/asparaginase capsules prepared by ultrasound to retain ammonia.

    Science.gov (United States)

    Tinoco, Ana; Ribeiro, Artur; Oliveira, César; Parpot, Pier; Gomes, Andreia; Cavaco-Paulo, Artur

    2016-11-01

    Asparaginase reduces the levels of asparagine in blood, which is an essential amino acid for the proliferation of lymphoblastic malign cells. Asparaginase converts asparagine into aspartic acid and ammonia. The accumulation of ammonia in the bloodstream leads to hyperammonemia, described as one of the most significant side effects of asparaginase therapy. Therefore, there is a need for asparaginase formulations with the potential to reduce hyperammonemia. We incorporated 2 % of therapeutic enzyme in albumin-based capsules. The presence of asparaginase in the interface of bovine serum albumin (BSA) capsules showed the ability to hydrolyze the asparagine and retain the forming ammonia at the surface of the capsules. The incorporation of Poloxamer 407 in the capsule formulation further increased the ratio aspartic acid/ammonia from 1.92 to 2.46 (and 1.10 from the free enzyme), decreasing the levels of free ammonia. This capacity to retain ammonia can be due to electrostatic interactions and retention of ammonia at the surface of the capsules. The developed BSA/asparaginase capsules did not cause significant cytotoxic effect on mouse leukemic macrophage cell line RAW 264.7. The new BSA/asparaginase capsules could potentially be used in the treatment of acute lymphoblastic leukemia preventing hyperammonemia associated with acute lymphoblastic leukemia (ALL) treatment with asparaginase.

  1. Patency(C) and agile(C) capsules

    Institute of Scientific and Technical Information of China (English)

    àngel Caunedo-àlvarez; Javier Romero-Vazquez; Juan M Herrerias-Gutierrez

    2008-01-01

    Small bowel strictures can be missed by current diagnostic methods.The Patency capsule is a new non-endoscopic dissolvable capsule which has as an objective of checking the patency of digestive tract,in a non-invasive manner.The available clinical trials have demonstrated that the Patency(C) capsule is a good tool for assessment of the functional patency of the small bowel,and it allows identification of those patients who can safely undergo a capsule endoscopy,despite clinical and radiographic evidence of small-bowel obstruction.Some cases of intestinal occlusion have been reported with the Patency(C) capsule,four of them needed surgery.So,a new capsule with two timer plugs (Agile(C) capsule) has been recently developed in order to minimize the risk of occlusion.This new device stars its dissolution process earlier (30 h after ingestion) and its two timer plugs have been designed to begin the disintegration even when the device is blocked in a tight stricture.

  2. Emerging Issues and Future Developments in Capsule Endoscopy.

    Science.gov (United States)

    Slawinski, Piotr R; Obstein, Keith L; Valdastri, Pietro

    2015-01-01

    Capsule endoscopy (CE) has transformed from a research venture into a widely used clinical tool and the primary means for diagnosing small bowel pathology. These orally administered capsules traverse passively through the gastrointestinal tract via peristalsis and are used in the esophagus, stomach, small bowel, and colon. The primary focus of CE research in recent years has been enabling active CE manipulation and extension of the technology to therapeutic functionality; thus, widening the scope of the procedure. This review outlines clinical standards of the technology as well as recent advances in CE research. Clinical capsule applications are discussed with respect to each portion of the gastrointestinal tract. Promising research efforts are presented with an emphasis on enabling active capsule locomotion. The presented studies suggest, in particular, that the most viable solution for active capsule manipulation is actuation of a capsule via exterior permanent magnet held by a robot. Developing capsule procedures adhering to current healthcare standards, such as enabling a tool channel or irrigation in a therapeutic device, is a vital phase in the adaptation of CE in the clinical setting.

  3. Current Clinical Indications for Small Bowel Capsule Endoscopy.

    Science.gov (United States)

    Rosa, Bruno; Cotter, José

    2015-01-01

    Small bowel capsule endoscopy is currently the first line diagnostic examination for many diseases affecting the small bowel. This article aims to review and critically address the current indications of small bowel capsule endoscopy in clinical practice. Bibliographic review of relevant and recent papers indexed in PubMed. Small bowel capsule endoscopy enables a non-invasive full-assessment of the small bowel mucosa, with high diagnostic yield even for subtle lesions. In patients with obscure gastrointestinal bleeding, diagnostic yield is higher when performed early after the onset of bleeding. Endoscopic treatment of angioectasias using balloon-assisted enteroscopy may contribute to reduce rebleeding, while the risk of rebleeding in patients with 'negative' small bowel capsule endoscopy is debatable. Cross-sectional imaging may be more accurate than small bowel capsule endoscopy for the diagnosis of large small bowel tumors. The Smooth Protruding Index on Capsule Endoscopy (SPICE score) may help to differentiate submucosal tumors from innocent bulges. Small bowel capsule endoscopy is also a key diagnostic instrument in patients with suspected Crohn's disease and non-diagnostic ileocolonoscopy; it may also influence prognosis and therapeutic management, by determining disease extent and activity in patients with known Crohn's disease. The role of small bowel capsule endoscopy to investigate possible complications in patients with non-responsive coeliac disease is evolving. Small bowel capsule endoscopy is a valuable diagnostic instrument for patients with obscure gastrointestinal bleeding and/or suspected small bowel tumors; it may also be a key examination in patients with suspected Crohn's disease, or patients with known Crohn's disease to fully assess disease extension and activity; finally, it may contribute for the diagnosis of complications of non-responsive coeliac disease.

  4. Solid State Stability of Extemporaneously Prepared Levothyroxine Aliquots and Capsules.

    Science.gov (United States)

    Fortner, Jeff; Salton, Jason; Carlson, Christie; Wheeler, Rich; Cote, Brianna; Rao, Deepa

    2015-01-01

    The purpose of this research was to collect, analyze, and compare stability data for levothyroxine (T4) powder in the anhydrous and pentahydrate form when prepared as an aliquot and in capsules. Two different compounding pharmacies, Central Iowa Compounding and Gateway Medical Pharmacy, used different forms of T4 and aliquot formulations, which were studied to determine the beyond-use date at ±5% or ±10% of labeled strength. T4 was extracted from aliquot and capsule formulations and assessed using reverse-phase high- performance liquid chromatography validated to differentiate between the degraded and original forms of T4. The results indicate that T4 1:100 aliquot formulation prepared with silica gel or Avicel as filler are stable for 120 days at ±10% labeled potency, but at ±5% labeled potency, the silica gel and Avicel aliquot formulations are stable for 45 and 30 days, respectively. The silica gel capsules prepared from fresh aliquot were stable for 120 days at ±10% labeled potency and 90 days at ±5% labeled potency, while the Avicel capsules prepared from fresh aliquot were stable for 180 days at both ±10% and ±5% labeled potency. Avicel capsules prepared from old aliquot (120 days) and fresh aliquot (1 day) were also compared for stability. The old aliquot Avicel capsules were stable for 14 days at ±5% labeled potency and 150 days at ±10% labeled potency, while new aliquot Avicel capsules were stable for 180 days at both ±10% and ±5% labeled potency. Based on our data, there can be significant variation in the beyond-use dates assigned to T4 capsules based on the diluents used for aliquots, the final capsule formulations, and the potency standards applied. These results also indicate that pharmacists must exercise caution when using older aliquots and may have to assign shorter beyond-use dates.

  5. Solar-blind ultraviolet optical system design for missile warning

    Science.gov (United States)

    Chen, Yu; Huo, Furong; Zheng, Liqin

    2015-03-01

    Solar-blind region of Ultraviolet (UV) spectrum has very important application in military field. The spectrum range is from 240nm to 280nm, which can be applied to detect the tail flame from approaching missile. A solar-blind UV optical system is designed to detect the UV radiation, which is an energy system. iKon-L 936 from ANDOR company is selected as the UV detector, which has pixel size 13.5μm x 13.5 μm and active image area 27.6mm x 27.6 mm. CaF2 and F_silica are the chosen materials. The original structure is composed of 6 elements. To reduce the system structure and improve image quality, two aspheric surfaces and one diffractive optical element are adopted in this paper. After optimization and normalization, the designed system is composed of five elements with the maximum spot size 11.988μ m, which is less than the pixel size of the selected CCD detector. Application of aspheric surface and diffractive optical element makes each FOV have similar spot size, which shows the system almost meets the requirements of isoplanatic condition. If the focal length can be decreased, the FOV of the system can be enlarged further.

  6. China and ballistic missile defense: 1955 to 2002 and beyond

    Energy Technology Data Exchange (ETDEWEB)

    Brad, Roberts

    2004-07-01

    China's opposition to U.S. ballistic missile defense was forcefully articulated officially and unofficially between 1991 and 2001. Vociferous opposition gave way to near silence following U.S. ABM Treaty withdrawal, raising a question about precisely whether and how China will respond to future U.S. deployments in both the political and military-operational realms. To gauge likely future responses, it is useful to put the experience of the 1991-2001 period into historical context. China's attitudes toward BMD have passed through a series of distinct phases since the beginning of the nuclear era, as China has been concerned alternately with the problems of strategic defense by both the Soviet Union and United States (and others) around its periphery. Throughout this era it has also pursued its own strategic defense capabilities. There are important elements of continuity in China's attitudes concerns about the viability of its own force and about strategic stability. These suggest the likelihood of significant responses to U.S. BMD even in the absence of sharp rhetoric. (author)

  7. An affinity-directed protein missile system for targeted proteolysis

    Science.gov (United States)

    Fulcher, Luke J.; Macartney, Thomas; Bozatzi, Polyxeni; Hornberger, Annika; Rojas-Fernandez, Alejandro

    2016-01-01

    The von Hippel–Lindau (VHL) protein serves to recruit the hypoxia-inducible factor alpha (HIF1α) protein under normoxia to the CUL2 E3 ubiquitin ligase for its ubiquitylation and degradation through the proteasome. In this report, we modify VHL to engineer an affinity-directed protein missile (AdPROM) system to direct specific endogenous target proteins for proteolysis in mammalian cells. The proteolytic AdPROM construct harbours a cameloid anti-green fluorescence protein (aGFP) nanobody that is fused to VHL for either constitutive or tetracycline-inducible expression. For target proteins, we exploit CRISPR/Cas9 to rapidly generate human kidney HEK293 and U2OS osteosarcoma homozygous knock-in cells harbouring GFP tags at the VPS34 (vacuolar protein sorting 34) and protein associated with SMAD1 (PAWS1, aka FAM83G) loci, respectively. Using these cells, we demonstrate that the expression of the VHL-aGFP AdPROM system results in near-complete degradation of the endogenous GFP-VPS34 and PAWS1-GFP proteins through the proteasome. Additionally, we show that Tet-inducible destruction of GFP-VPS34 results in the degradation of its associated partner, UVRAG, and reduction in levels of cellular phosphatidylinositol 3-phosphate. PMID:27784791

  8. Researches on Magnetic Localization for Detecting Capsule in Gastrointestinal Tract

    Institute of Scientific and Technical Information of China (English)

    HE Wen-hui; YAN Guo-zheng; GUO Xu-dong; WANG Kun-dong

    2007-01-01

    Recently, the capsule detection for examination of gastrointestinal (GI) tract became a novel noninvasive system, but it was still a problem for capsule's location.This paper examined various technologies used for measuring position based on magnetic method of the capsule in GI tract, while some new methods were investigated and their efficiency and complexity were analyzed.The results show that the radio frequency location is only practicable, but the tri-coil stimulating magnetic method and magnetic marker method can help to acquire a high precise, simplified, efficient and localized device.

  9. Characterisation of two AGATA asymmetric high purity germanium capsules

    Energy Technology Data Exchange (ETDEWEB)

    Colosimo, S.J., E-mail: sjc@ns.ph.liv.ac.uk [Department of Physics, Oliver Lodge Laboratory, University of Liverpool, Liverpool L69 7ZE (United Kingdom); Moon, S.; Boston, A.J.; Boston, H.C.; Cresswell, J.R.; Harkness-Brennan, L.; Judson, D.S. [Department of Physics, Oliver Lodge Laboratory, University of Liverpool, Liverpool L69 7ZE (United Kingdom); Lazarus, I.H. [STFC Daresbury, Daresbury, Warrington WA4 4AD (United Kingdom); Nolan, P.J. [Department of Physics, Oliver Lodge Laboratory, University of Liverpool, Liverpool L69 7ZE (United Kingdom); Simpson, J. [STFC Daresbury, Daresbury, Warrington WA4 4AD (United Kingdom); Unsworth, C. [Department of Physics, Oliver Lodge Laboratory, University of Liverpool, Liverpool L69 7ZE (United Kingdom)

    2015-02-11

    The AGATA spectrometer is an array of highly segmented high purity germanium detectors. The spectrometer uses pulse shape analysis in order to track Compton scattered γ-rays to increase the efficiency of nuclear spectroscopy studies. The characterisation of two high purity germanium detector capsules for AGATA of the same A-type has been performed at the University of Liverpool. This work will examine the uniformity of performance of the two capsules, including a comparison of the resolution and efficiency as well as a study of charge collection. The performance of the capsules shows good agreement, which is essential for the efficient operation of the γ-ray tracking array.

  10. Simulation Study on the Feasibility of Gun-Launched Missile Against Attack Helicopters

    Institute of Scientific and Technical Information of China (English)

    王狂飙; 张天桥

    2001-01-01

    The feasibility of providing the tank a limited anti-helicopterability with gun-launched missile is studied. A type of simulation model of gun-launched missile against attack helicopters is established. The simulation and the parameter optimization of missile control system under various circumstances are done. The gun-launched missile can directly hit the helicopters in the typical tracks, all the missdistances are less than 1 m and the maximum overload is less than available overload. Gun-launched missile is a feasible choice for tanks against attack helicopters.%研究通过炮射反坦克导弹赋予坦克有限反武装直升机能力的可行性.建立了一种炮射导弹与武装直升机对抗的仿真模型,并在各种情况下进行了系统仿真与导弹控制系统参数优化.经参数优化的炮射导弹在给定的武装直升机各种航迹下,均可直接命中,脱靶量均小于1m,最大过载不超过可用过载.仿真结果表明炮射导弹是坦克对抗武装直升机的一种可行的选择.

  11. Use of noise attenuation modeling in managing missile motor detonation activities.

    Science.gov (United States)

    McFarland, Michael J; Watkins, Jeffrey W; Kordich, Micheal M; Pollet, Dean A; Palmer, Glenn R

    2004-03-01

    The Sound Intensity Prediction System (SIPS) and Blast Operation Overpressure Model (BOOM) are semiempirical sound models that are employed by the Utah Test and Training Range (UTTR) to predict whether noise levels from the detonation of large missile motors will exceed regulatory thresholds. Field validation of SIPS confirmed that the model was effective in limiting the number of detonations of large missile motors that could potentially result in a regulatory noise exceedance. Although the SIPS accurately predicted the impact of weather on detonation noise propagation, regulators have required that the more conservative BOOM model be employed in conjunction with SIPS in evaluating peak noise levels in populated areas. By simultaneously considering the output of both models, in 2001, UTTR detonated 104 missile motors having net explosive weights (NEW) that ranged between 14,960 and 38,938 lb without a recorded public noise complaint. Based on the encouraging results, the U.S. Department of Defense is considering expanding the application of these noise models to support the detonation of missile motors having a NEW of 81,000 lb. Recent modeling results suggest that, under appropriate weather conditions, missile motors containing up to 96,000 lb NEW can be detonated at the UTTR without exceeding the regulatory noise limit of 134 decibels (dB).

  12. Signature analysis of ballistic missile warhead with micro-nutation in terahertz band

    Science.gov (United States)

    Li, Ming; Jiang, Yue-song

    2013-08-01

    In recent years, the micro-Doppler effect has been proposed as a new technique for signature analysis and extraction of radar targets. The ballistic missile is known as a typical radar target and has been paid many attentions for the complexities of its motions in current researches. The trajectory of a ballistic missile can be generally divided into three stages: boost phase, midcourse phase and terminal phase. The midcourse phase is the most important phase for radar target recognition and interception. In this stage, the warhead forms a typical micro-motion called micro-nutation which consists of three basic micro-motions: spinning, coning and wiggle. This paper addresses the issue of signature analysis of ballistic missile warhead in terahertz band via discussing the micro-Doppler effect. We establish a simplified model (cone-shaped) for the missile warhead followed by the micro-motion models including of spinning, coning and wiggle. Based on the basic formulas of these typical micro-motions, we first derive the theoretical formula of micro-nutation which is the main micro-motion of the missile warhead. Then, we calculate the micro-Doppler frequency in both X band and terahertz band via these micro-Doppler formulas. The simulations are given to show the superiority of our proposed method for the recognition and detection of radar micro targets in terahertz band.

  13. Wind Tunnel Experimental Investigation on the Aerodynamic Characteristics of the Multifin Rockets and Missiles

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The transonic-supersonic wind tunnel experiment on the aerodynamics of the rockets and missiles that have four, six, eight flat or wrap-around fins is introduced. The experimental results show, while M∞<2.0, with the increase of the fins' number, the derivative of lift coefficient is increasing, the pressure center is shifting backwards, and the longitudinal static stability is augmenting. On the contrary, while the Mach number exceeds a certain supersonic value, the aerodynamic effectiveness of the eight-fin missiles would be lower than that of the six-fin missiles. For the low speed short-range missiles, by adopting six, eight or ten flat fins configuration, the lift effectiveness can be greatly increased, the pressure center can be shifted backwards, the static and dynamic stability can be obviously enhanced. For the high speed long-range large rockets and missiles launched from multi-tube launcher, the configuration adopting more than six fins can not be useful for increasing the stability but would make the rolling rate instable during the flight.

  14. An evaluation method for tornado missile strike probability with stochastic correction

    Energy Technology Data Exchange (ETDEWEB)

    Eguchi, Yuzuru; Murakami, Takahiro; Hirakuchi, Hiromaru; Sugimoto, Soichiro; Hattori, Yasuo [Nuclear Risk Research Center (External Natural Event Research Team), Central Research Institute of Electric Power Industry, Abiko (Japan)

    2017-03-15

    An efficient evaluation method for the probability of a tornado missile strike without using the Monte Carlo method is proposed in this paper. A major part of the proposed probability evaluation is based on numerical results computed using an in-house code, Tornado-borne missile analysis code, which enables us to evaluate the liftoff and flight behaviors of unconstrained objects on the ground driven by a tornado. Using the Tornado-borne missile analysis code, we can obtain a stochastic correlation between local wind speed and flight distance of each object, and this stochastic correlation is used to evaluate the conditional strike probability, QV(r), of a missile located at position r, where the local wind speed is V. In contrast, the annual exceedance probability of local wind speed, which can be computed using a tornado hazard analysis code, is used to derive the probability density function, p(V). Then, we finally obtain the annual probability of tornado missile strike on a structure with the convolutional integration of product of QV(r) and p(V) over V. The evaluation method is applied to a simple problem to qualitatively confirm the validity, and to quantitatively verify the results for two extreme cases in which an object is located just in the vicinity of or far away from the structure.

  15. Comparison of different lateral acceleration autopilots for a surface-to-surface missile

    Directory of Open Access Journals (Sweden)

    Danilo V. Ćuk

    2011-07-01

    Full Text Available This paper presents a comparison of three lateral acceleration autopilots for a surface-to-surface missile: three-loop conventional acceleration autopilot, and gamma-dot and three-loop acceleration autopilot based upon the inverse-dynamic control. The surface-to-surface missile motion is described by nonlinear differential equations whose parameters change rapidly over a very wide range due to variable velocity and altitude. The requirement for the accurate controlling of the missile in such an environment represents a challenge for the autopilot designer. The brief review of the calculation of the autopilot gains is given using the concept of the 'point' stability for the linear time-varying system with 'frozen' dynamic coefficients. The method of the inverse-dynamic control is presented in the next section for two types of the autopilots: gamma-dot and acceleration autopilot. Both of them require the design of the estimators for the variables used as inputs to the control law. Finally, six-degree-of-freedom simulation results of the missile response to the demanded command on the typical ballistic trajectory are presented. The comparison of three autopilots considers the steady state errors and the sensitivity of the response to the highly variable environment. It was shown that the inverse-dynamic control can be very effective in the controlling of the surface-to-surface missile.

  16. 77 FR 66621 - Draft Guidance for Industry on Bioequivalence Recommendation for Lenalidomide Capsules; Availability

    Science.gov (United States)

    2012-11-06

    ... for Lenalidomide Capsules; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice... lenalidomide capsules. The draft guidance is a revised version of a previously published draft guidance on the... availability of revised draft BE recommendations for lenalidomide capsules. Revlimid (lenalidomide capsules...

  17. Design and synthesis of organic-inorganic hybrid capsules for biotechnological applications.

    Science.gov (United States)

    Shi, Jiafu; Jiang, Yanjun; Wang, Xiaoli; Wu, Hong; Yang, Dong; Pan, Fusheng; Su, Yanlei; Jiang, Zhongyi

    2014-08-07

    Organic-inorganic hybrid capsules, which typically possess a hollow lumen and a hybrid wall, have emerged as a novel and promising class of hybrid materials and have attracted enormous attention. In comparison to polymeric capsules or inorganic capsules, the hybrid capsules combine the intrinsic physical/chemical properties of the organic and inorganic moieties, acquire more degrees of freedom to manipulate multiple interactions, create hierarchical structures and integrate multiple functionalities. Thus, the hybrid capsules exhibit superior mechanical strength (vs. polymeric capsules) and diverse functionalities (vs. inorganic capsules), which may give new opportunities to produce high-performance materials. Much effort has been devoted to exploring innovative and effective methods for the synthesis of hybrid capsules that exhibit desirable performance in target applications. This tutorial review firstly presents a brief description of the capsular structure and hybrid materials in nature, then classifies the hybrid capsules into molecule-hybrid capsules and nano-hybrid capsules based upon the size of the organic and inorganic moieties in the capsule wall, followed by a detailed discussion of the design and synthesis of the hybrid capsules. For each kind of hybrid capsule, the state-of-the-art synthesis methods are described in detail and a critical comment is embedded. The applications of these hybrid capsules in biotechnological areas (biocatalysis, drug delivery, etc.) have also been summarized. Hopefully, this review will offer a perspective and guidelines for the future research and development of hybrid capsules.

  18. A Study of the Effects of Sensor Noise and Guidance Laws on SAM Effectiveness Against Cruise Missiles

    Science.gov (United States)

    2015-06-01

    k guidance acceleration command vector xviii THIS PAGE INTENTIONALLY LEFT BLANK xix EXECUTIVE SUMMARY Cruise missile (CM) technology is...Germany, Netherlands, UK, Denmark Turkey, Romania, Poland, and Spain ) contributed to the Maritime Theatre Missile Defence Forum to obtain an impressive

  19. 15 CFR 744.3 - Restrictions on Certain Rocket Systems (including ballistic missile systems and space launch...

    Science.gov (United States)

    2010-01-01

    ... Vehicles (including cruise missile systems, target drones and reconnaissance drones) End-Uses. 744.3... missile systems, target drones and reconnaissance drones) End-Uses. (a) General prohibition. In addition... transfer (in-country) you know that the item: (1) Will be used in the design, development, production...

  20. Digital Array Radar for Ballistic Missile Defense and Counter-Stealth Systems Analysis and Parameter Tradeoff Study

    Science.gov (United States)

    2006-09-14

    Missile BMD Ballistic Missile Defense CAS Computer Algebra System CDD Capability Development Document CONOPS Concept of Operations CONUS Continental...this section. Analysis and calculations described in this section were conducted using Waterloo Maple® 7 Computer Algebra System (CAS). Initially...When two or more electromagnetic waves combine, their electric fields are integrated vectorially at each point in space for any

  1. 77 FR 64564 - Implementation of Regulatory Guide 1.221 on Design-Basis Hurricane and Hurricane Missiles

    Science.gov (United States)

    2012-10-22

    ... COMMISSION Implementation of Regulatory Guide 1.221 on Design-Basis Hurricane and Hurricane Missiles AGENCY....221 on Design-Basis Hurricane and Hurricane Missiles.'' The purpose of this ISG is to supplement the guidance regarding the application of Regulatory Guide 1.221, ``Design-Basis Hurricane and...

  2. Emerging methods for the fabrication of polymer capsules.

    Science.gov (United States)

    Cui, Jiwei; van Koeverden, Martin P; Müllner, Markus; Kempe, Kristian; Caruso, Frank

    2014-05-01

    Hollow polymer capsules are attracting increasing research interest due to their potential application as drug delivery vectors, sensors, biomimetic nano- or multi-compartment reactors and catalysts. Thus, significant effort has been directed toward tuning their size, composition, morphology, and functionality to further their application. In this review, we provide an overview of emerging techniques for the fabrication of polymer capsules, encompassing: self-assembly, layer-by-layer assembly, single-step polymer adsorption, bio-inspired assembly, surface polymerization, and ultrasound assembly. These techniques can be applied to prepare polymer capsules with diverse functionality and physicochemical properties, which may fulfill specific requirements in various areas. In addition, we critically evaluate the challenges associated with the application of polymer capsules in drug delivery systems. © 2013.

  3. [Acute caffeine intoxication after intake of 'herbal energy capsules'

    NARCIS (Netherlands)

    Kromhout, H.E.; Landstra, A.M.; Luin, M. van; Setten, P.A. van

    2008-01-01

    Two males, 15 and 17 years old respectively, presented at the Emergency Department complaining of cramping abdominal pain, nausea and vomiting after ingestion of energy capsules. Physical examination revealed sinus tachycardia and slight abdominal pain. Laboratory examination showed substantial

  4. The mechanical properties of the human hip capsule ligaments.

    Science.gov (United States)

    Hewitt, John D; Glisson, Richard R; Guilak, Farshid; Vail, T Parker

    2002-01-01

    The human hip capsule is adapted to facilitate upright posture, joint stability, and ambulation, yet it routinely is excised in hip surgery without a full understanding of its mechanical contributions. The objective of this study was to provide information about the mechanical properties of the ligaments that form the hip capsule. Cadaver bone-ligament-bone specimens of the iliofemoral, ischiofemoral, and femoral arcuate ligaments were tested to failure in tension. The hip capsule was found to be an inhomogeneous structure and should be recognized as being composed of discrete constituent ligaments. The anterior ligaments, consisting of the 2 arms of the iliofemoral ligament, were much stronger than the posterior ischiofemoral ligament, withstanding greater force at failure and exhibiting greater stiffness. Knowledge of the anatomy and mechanical properties of the capsule may help the hip surgeon choose an appropriate surgical approach or repair strategy.

  5. [Acute caffeine intoxication after intake of 'herbal energy capsules'

    NARCIS (Netherlands)

    Kromhout, H.E.; Landstra, A.M.; Luin, M. van; Setten, P.A. van

    2008-01-01

    Two males, 15 and 17 years old respectively, presented at the Emergency Department complaining of cramping abdominal pain, nausea and vomiting after ingestion of energy capsules. Physical examination revealed sinus tachycardia and slight abdominal pain. Laboratory examination showed substantial hypo

  6. Wireless capsule video endoscopy:Three years of experience

    Institute of Scientific and Technical Information of China (English)

    Rami Eliakim

    2004-01-01

    AIM: To review and summerize the current literatue regarding M2A wireless capsule endoscopy.METHODS: Peer reviewed publications regarding the use of capsule endoscopy as well as our personal experience were reviewed.RESULTS: Review of the literature dearly showed that capsule endoscopy was superior to enteroscopy, small bowel follow through and computerized tomography in patients with obscure gastrointestinal bleeding, iron deficiency anemia,or suspected Crohn′s disease. It was very sensitive for the diagnosis of small bowel tumors and for survailance of small bowel pathology in patients with Gardner syndrome or familial adenomatous polyposis syndrome. Its role in celiac disease and in patients with known Crohn′s disease was currently being investigated.CONCLUSION: Capsule video endoscopy is a superior and more sensitive diagnostic tool than barium follow through,enteroscopy and entero- CT in establishing the diagnosis of many small bowel pathologies.

  7. Capsule endoscopy of the future: What's on the horizon?

    Science.gov (United States)

    Slawinski, Piotr R; Obstein, Keith L; Valdastri, Pietro

    2015-10-01

    Capsule endoscopes have evolved from passively moving diagnostic devices to actively moving systems with potential therapeutic capability. In this review, we will discuss the state of the art, define the current shortcomings of capsule endoscopy, and address research areas that aim to overcome said shortcomings. Developments in capsule mobility schemes are emphasized in this text, with magnetic actuation being the most promising endeavor. Research groups are working to integrate sensor data and fuse it with robotic control to outperform today's standard invasive procedures, but in a less intrusive manner. With recent advances in areas such as mobility, drug delivery, and therapeutics, we foresee a translation of interventional capsule technology from the bench-top to the clinical setting within the next 10 years.

  8. Multiaxial mechanical behavior of the porcine anterior lens capsule.

    Science.gov (United States)

    Heistand, M R; Pedrigi, R M; Delange, S L; Dziezyc, J; Humphrey, J D

    2005-11-01

    The biomechanics of the lens capsule of the eye is important both in physiologic processes such as accommodation and clinical treatments such as cataract surgery. Although the lens capsule experiences multiaxial stresses in vivo, there have been no measurements of its multiaxial properties or possible regional heterogeneities. Rather all prior mechanical data have come from 1-D pressure-volume or uniaxial force-length tests. Here, we report a new experimental approach to study in situ the regional, multiaxial mechanical behavior of the lens capsule. Moreover, we report multiaxial data suggesting that the porcine anterior lens capsule exhibits a typical nonlinear pseudo-elastic behavior over finite strains, that the in situ state is pre-stressed multi-axially, and that the meridional and circumferential directions are principal directions of strain, which is nearly equi-biaxial at the pole but less so towards the equator. Such data are fundamental to much needed constitutive formulations.

  9. Inhibition of phage infection in capsule-producing Streptococcus ...

    African Journals Online (AJOL)

    SERVER

    2007-10-04

    Oct 4, 2007 ... Acid production by capsule-producing Streptococcus thermophilus was inhibited less ... lactic acid bacteria (LAB) are of similar size to fat globules ..... Characterization of new virulent phage (MLC-A) of Lactobacillus paracasei.

  10. Perforation forces of the intact porcine anterior lens capsule.

    Science.gov (United States)

    Ullrich, Franziska; Lussi, Jonas; Felekis, Dimitrios; Michels, Stephan; Petruska, Andrew J; Nelson, Bradley J

    2016-09-01

    During the first step of cataract surgery, the lens capsule is perforated and a circular hole is created with a sharp instrument, a procedure called capsulorhexis. To develop automated systems that can assist ophthalmologists during capsulorhexis, the forces required must be quantified. This study investigates perforation forces of the central anterior lens capsule in porcine eyes, which are used as a conservative model for the human eye. A micro-mechanical characterisation method is presented that measures capsular bag perforation forces with a high precision positioning and high-resolution force sensing system. The force during perforation of the anterior lens capsule was measured with various sized needles and indentation speeds and is found to be 15-35mN. A bio-mechanical model is identified that describes an exponential correlation between indentation force and depth, indicating strain hardening behaviour of the porcine anterior lens capsule.

  11. Determining the Optimum Font Size for Braille on Capsule Paper

    OpenAIRE

    Watanabe, Tetsuya

    2014-01-01

    Braille fonts allow us to easily make braille labels on capsule paper. For legibility, fonts should be printed at optimum sizes. To find the optimum sizes for Japanese braille fonts, we conducted an experiment in which a Japanese braille font was printed at various sizes on capsule paper and read and rated by young braille users. The results show that braille printed at 17 and 18 point sizes were read faster and evaluated higher than those printed at smaller or bigger sizes.

  12. Granular computing in mosaicing of images from capsule endoscopy

    OpenAIRE

    Maciura, Lukasz; Bazan, Jan G.

    2015-01-01

    This article introduces methods for modeling compound granules used in algorithms which could successfully construct a mosaic from the images coming from an endoscope capsule. In order to apply the algorithm, combined images must have a common area where the correspondence of points is determined. That allows to determine the transformation parameters to compensate movement of the capsule that occurs between moments when the mosaic images were acquired. The developed algorithm for images from...

  13. Research on Technology of Filling Sodium into Fuel Test Capsules

    Institute of Scientific and Technical Information of China (English)

    XU; Chi; XIE; Chun; WANG; Shu-xing; MI; Zheng-feng; YU; Tuan-jie; CUI; Chao; WANG; Ming-zheng

    2015-01-01

    In order to provide a high pure sodium environment for properties testing in the fuel research for fast reactor,it is essential to fill sodium into fuel testing capsules.By the method of vacuum,temperature-controlling and inert gas protection,quantificational sodium had been filled into the fuel testing capsules.Fig.1shows the schematic diagram of sodium filling device.Table 1shows

  14. Study of Contact Melting Inside Isothermally Heated Vertical Cylindrical Capsules

    Institute of Scientific and Technical Information of China (English)

    ChenWenzhen; ChengShangmo; 等

    1993-01-01

    Close-contact melting processes of phase change material(PCM) inside vertical cylindrical capsule are studied.PCM are heated bhy the capsule isothermalyy at the bottom and side.The theoretical formulas of the melting rate and thickness of liquid layer during the heat transfer process are obtained by analysis,which are convenient for engineering predictions.Finally,the factors that affect melting are discussed.and conclusions are drawn.

  15. Guidance Law and Neural Control for Hypersonic Missile to Track Targets

    Directory of Open Access Journals (Sweden)

    Wenxing Fu

    2016-01-01

    Full Text Available Hypersonic technology plays an important role in prompt global strike. Because the flight dynamics of a hypersonic vehicle is nonlinear, uncertain, and highly coupled, the controller design is challenging, especially to design its guidance and control law during the attack of a maneuvering target. In this paper, the sliding mode control (SMC method is used to develop the guidance law from which the desired flight path angle is derived. With the desired information as control command, the adaptive neural control in discrete time is investigated ingeniously for the longitudinal dynamics of the hypersonic missile. The proposed guidance and control laws are validated by simulation of a hypersonic missile against a maneuvering target. It is demonstrated that the scheme has good robustness and high accuracy to attack a maneuvering target in the presence of external disturbance and missile model uncertainty.

  16. A Direct Multiple Shooting Method for Missile Trajectory Optimization with The Terminal Bunt Manoeuvre

    Directory of Open Access Journals (Sweden)

    S. Subchan Subchan

    2011-08-01

    Full Text Available Numerical solution of constrained nonlinear optimal control problem is an important field in a wide range of applications in science and engineering. The real time solution for an optimal control problem is a challenge issue especially the state constrained handling. Missile trajectory shaping with terminal bunt manoeuvre with state constaints is addressed. The problem can be stated as an optimal control problem in which an objective function is minimised satisfying a series of constraints on the trajectory which includes state and control constraints. Numerical solution based on a direct multiple shooting is proposed. As an example the method has been implemented to a design of optimal trajectory for a missile where the missile must struck the target by vertical dive. The qualitative analysis and physical interpretation of the numerical solutions are given.

  17. Improved manufacturing techniques for rf and laser hardening of missile domes, phase 1

    Science.gov (United States)

    Pawlewicz, W. T.; Mann, I. B.; Martin, P. M.; Hays, D. D.; Graybeal, A. G.

    1982-07-01

    The adaptation of an existing Pacific Northwest Laboratory (PNL) optical coating capability developed for high power fusion laser applications to the case of RF and laser hardening of plastic missile domes used by US Army (MICOM) is reported. RF hardening of Hellfire and Copperhead 1.06 micron missile domes by use of transparent conductive Indium Tin Oxide (ITO) coatings is demonstrated. The project involved adaptation of a coating material and process developed for flat glass components used in fusion lasers to the case of hemispherical or conical heat sensitive plastic domes used on laser guided missiles. Specific ITO coating property goals are an electrical sheet resistance of 10 ohms/square, a coated dome transmission of 80% or more at 1.06 micron wavelength (compared to 90% for a bare dome), and good adhesion. The sheet resistance goal of 10 ohms/square was expected to result in an RF attenuation of 30 dB at the frequencies of importance.

  18. A method for simulating the atmospheric entry of long-range ballistic missiles

    Science.gov (United States)

    Eggers, A J , Jr

    1958-01-01

    It is demonstrated with the aid of similitude arguments that a model launched from a hypervelocity gun upstream through a special supersonic nozzle should experience aerodynamic heating and resulting thermal stresses like those encountered by a long-range ballistic missile entering the earth's atmosphere. This demonstration hinges on the requirements that model and missile be geometrically similar and made of the same material, and that they have the same flight speed and Reynolds number (based on conditions just outside the boundary layer) at corresponding points in their trajectories. The hypervelocity gun provides the model with the required initial speed, while the nozzle scales the atmosphere, in terms of density variation, to provide the model with speeds and Reynolds numbers over its entire trajectory. Since both the motion and aerodynamic heating of a missile tend to be simulated in the model tests, this combination of hypervelocity gun and supersonic nozzle is termed an atmosphere entry simulator.

  19. Autopilot Design Method for the Blended Missile Based on Model Predictive Control

    Directory of Open Access Journals (Sweden)

    Baoqing Yang

    2015-01-01

    Full Text Available This paper develops a novel autopilot design method for blended missiles with aerodynamic control surfaces and lateral jets. Firstly, the nonlinear model of blended missiles is reduced into a piecewise affine (PWA model according to the aerodynamics properties. Secondly, based on the equivalence between the PWA model and mixed logical dynamical (MLD model, the MLD model of blended missiles is proposed taking into account the on-off constraints of lateral pulse jets. Thirdly, a hybrid model predictive control (MPC method is employed to design autopilot. Finally, simulation results under different conditions are presented to show the effectiveness of the proposed method, which demonstrate that control allocation between aerodynamic control surfaces and lateral jets is realized by adjusting the weighting matrix in an index function.

  20. Modeling gated neutron images of THD capsules

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Douglas Carl [Los Alamos National Laboratory; Grim, Gary P [Los Alamos National Laboratory; Tregillis, Ian L [Los Alamos National Laboratory; Wilke, Mark D [Los Alamos National Laboratory; Morgan, George L [Los Alamos National Laboratory; Loomis, Eric N [Los Alamos National Laboratory; Wilde, Carl H [Los Alamos National Laboratory; Oertel, John A [Los Alamos National Laboratory; Fatherley, Valerie E [Los Alamos National Laboratory; Clark, David D [Los Alamos National Laboratory; Schmitt, Mark J [Los Alamos National Laboratory; Merrill, Frank E [Los Alamos National Laboratory; Wang, Tai - Sen F [Los Alamos National Laboratory; Danly, Christopher R [Los Alamos National Laboratory; Batha, Steven H [Los Alamos National Laboratory; Patel, M [LLNL; Sepke, S [LLNL; Hatarik, R [LLNL; Fittinghoff, D [LLNL; Bower, D [LLNL; Marinak, M [LLNL; Munro, D [LLNL; Moran, M [LLNL; Hilko, R [NSTEC; Frank, M [LLNL; Buckles, R [NSTEC

    2010-01-01

    Time gating a neutron detector 28m from a NIF implosion can produce images at different energies. The brighter image near 14 MeV reflects the size and symmetry of the capsule 'hot spot'. Scattered neutrons, {approx}9.5-13 MeV, reflect the size and symmetry of colder, denser fuel, but with only {approx}1-7% of the neutrons. The gated detector records both the scattered neutron image, and, to a good approximation, an attenuated copy of the primary image left by scintillator decay. By modeling the imaging system the energy band for the scattered neutron image (10-12 MeV) can be chosen, trading off the decayed primary image and the decrease of scattered image brightness with energy. Modeling light decay from EJ399, BC422, BCF99-55, Xylene, DPAC-30, and Liquid A leads to a preference from BCF99-55 for the first NIF detector, but DPAC 30 and Liquid A would be preferred if incorporated into a system. Measurement of the delayed light from the NIF scintillator using implosions at the Omega laser shows BCF99-55 to be a good choice for down-scattered imaging at 28m.

  1. Internal capsule stroke in the common marmoset.

    Science.gov (United States)

    Puentes, S; Kaido, T; Hanakawa, T; Ichinohe, N; Otsuki, T; Seki, K

    2015-01-22

    White matter (WM) impairment and motor deficit after stroke are directly related. However, WM injury mechanisms and their relation to motor disturbances are still poorly understood. In humans, the anterior choroidal artery (AChA) irrigates the internal capsule (IC), and stroke to this region can induce isolated motor impairment. The goal of this study was to analyze whether AChA occlusion can injure the IC in the marmoset monkey. The vascular distribution of the marmoset brain was examined by colored latex perfusion and revealed high resemblance to the human brain anatomy. Next, a new approach to electrocoagulate the AChA was developed and chronic experiments showed infarction compromising the IC on magnetic resonance imaging (MRI) scanning (day 4) and histology (day 11). Behavioral analysis was performed using a neurologic score previously developed and our own scoring method. Marmosets showed a decreased score that was still evident at day 10 after AChA electrocoagulation. We developed a new approach able to induce damage to the marmoset IC that may be useful for the detailed study of WM impairment and behavioral changes after stroke in the nonhuman primate.

  2. Capsule Endoscopy for Portal Hypertensive Enteropathy

    Directory of Open Access Journals (Sweden)

    Seong Ran Jeon

    2016-01-01

    Full Text Available Portal hypertensive enteropathy (PHE is a mucosal abnormality of the small bowel that is observed in patients with portal hypertension (PH and can lead to gastrointestinal bleeding and anemia. The pathogenesis is still not completely understood. The introduction of new endoscopic methods, including capsule endoscopy (CE or balloon-assisted enteroscopy, has increased the detection of these abnormalities. CE can also serve as a road map for deciding subsequent interventions and evaluating the treatment effect. The prevalence of PHE is reportedly 40–70% in patients with PH. Endoscopic findings can be roughly divided into vascular and nonvascular lesions such as inflammatory-like lesions. Traditionally, PHE-associated factors include large esophageal varices, portal hypertensive gastropathy or colopathy, Child-Turcotte-Pugh class B or C, a history of variceal treatment, and acute gastrointestinal bleeding. More recently, on using scoring systems, a high computed tomography or transient elastography score was reportedly PHE-related factors. However, the prevalence of PHE and its related associated factors remain controversial. The management of PHE has not yet been standardized. It should be individualized according to each patient’s situation, the availability of therapy, and each institutional expertise.

  3. Electromagnetic wave propagation of wireless capsule endoscopy in human body

    Institute of Scientific and Technical Information of China (English)

    LIM; Eng-Gee; 王炤; 陈瑾慧; TILLO; Tammam; MAN; Ka-lok

    2013-01-01

    Wireless capsule endoscopy(WCE) is a promising technique which has overcome some limitations of traditional diagnosing tools, such as the comfortlessness of the cables and the inability of examining small intestine section. However, this technique is still far from mature and asks for the feasible improvements. For example, the relatively low transmission data rate and the absence of the real-time localization information of the capsule are all important issues. The studies of them rely on the understanding of the electromagnetic wave propagation in human body. Investigation of performance of WCE communication system was carried out by studying electromagnetic(EM) wave propagation of the wireless capsule endoscopy transmission channel. Starting with a pair of antennas working in a human body mimic environment, the signal transmissions and attenuations were examined. The relationship between the signal attenuation and the capsule(transmitter) position, and direction was also evaluated. These results provide important information for real-time localization of the capsule. Moreover, the pair of antennas and the human body were treated as a transmission channel, on which the binary amplitude shift keying(BASK) modulation scheme was used. The relationship between the modulation scheme, data rate and bit error rate was also determined in the case of BASK. With the obtained studies, it make possible to provide valuable information for further studies on the selection of the modulation scheme and the real-time localization of the capsules.

  4. Pickering Emulsion-Based Marbles for Cellular Capsules

    Directory of Open Access Journals (Sweden)

    Guangzhao Zhang

    2016-07-01

    Full Text Available The biodegradable cellular capsule, being prepared from simple vaporization of liquid marbles, is an ideal vehicle for the potential application of drug encapsulation and release. This paper reports the fabrication of cellular capsules via facile vaporization of Pickering emulsion marbles in an ambient atmosphere. Stable Pickering emulsion (water in oil was prepared while utilizing dichloromethane (containing poly(l-lactic acid and partially hydrophobic silica particles as oil phase and stabilizing agents respectively. Then, the Pickering emulsion marbles were formed by dropping emulsion into a petri dish containing silica particles with a syringe followed by rolling. The cellular capsules were finally obtained after the complete vaporization of both oil and water phases. The technique of scanning electron microscope (SEM was employed to research the microstructure and surface morphology of the prepared capsules and the results showed the cellular structure as expected. An in vitro drug release test was implemented which showed a sustained release property of the prepared cellular capsules. In addition, the use of biodegradable poly(l-lactic acid and the biocompatible silica particles also made the fabricated cellular capsules of great potential in the application of sustained drug release.

  5. Bushen Yisui Capsule ameliorates axonal injury in experimental autoimmune encephalomyelitis

    Institute of Scientific and Technical Information of China (English)

    Ling Fang; Lei Wang; Qi Zheng; Tao Yang; Hui Zhao; Qiuxia Zhang; Kangning Li; Li Zhou; Haiyang Gong; Yongping Fan

    2013-01-01

    A preliminary clinical study by our group demonstrated Bushen Yisui Capsule (formerly cal ed Er-huang Formula) in combination with conventional therapy is an effective prescription for the treat-ment of multiple sclerosis. However, its effect on axonal injury during early multiple sclerosis re-mains unclear. In this study, a MOG 35-55-immunized C57BL/6 mouse model of experimental au-toimmune encephalomyelitis was intragastrical y administered Bushen Yisui Capsule. The results showed that Bushen Yisui Capsule effectively improved clinical symptoms and neurological function of experimental autoimmune encephalomyelitis. In addition, amyloid precursor protein expression was down-regulated and microtubule-associated protein 2 was up-regulated. Experimental findings indicate that the disease-preventive mechanism of Bushen Yisui Capsule in experimental autoim-mune encephalomyelitis was mediated by amelioration of axonal damage and promotion of rege-neration. But the effects of the high-dose Bushen Yisui Capsule group was not better than that of the medium-dose and low-dose Bushen Yisui Capsule group in preventing neurological dysfunction.

  6. Pentagonal shaped microstrip patch antenna in wireless capsule endoscopy system

    Directory of Open Access Journals (Sweden)

    Bondili Kohitha Bai

    2012-01-01

    Full Text Available Wireless capsule endoscopy is a best option for exploring inaccessible areas of small intestine for inspection of gastrointestinal tract. This technique brings less pain compare to conventional endoscopy technique. The wireless endoscopy system comprises of three main modules: an ingestible capsule that is swallowed by the patient, an external control unit and display device for image display. In this paper we proposed pentagonal shape microstrip patch antenna for wireless capsule endoscopy system. Inhibiting characteristics of a single microstrip patch like low gain, light weight, thin thickness and smaller bandwidth, make it more popular. This kind of antenna is aggressive miniaturized to meet the requirements of the wireless capsule endoscope. The simulation results show that the designed Circular Polarization (CP pentagonal shaped microstrip patch antenna gives axial ratio of 0.6023 at 2.38 GHz and CP axial ratio bandwidth of 36MHz with 1.5%. The antenna designed for wireless capsule endoscopy is a proposed one, which may work effectively when compared to other antennas in the capsule.

  7. MALDI-MS-imaging of whole human lens capsule.

    Science.gov (United States)

    Ronci, Maurizio; Sharma, Shiwani; Chataway, Tim; Burdon, Kathryn P; Martin, Sarah; Craig, Jamie E; Voelcker, Nicolas H

    2011-08-05

    The ocular lens capsule is a smooth, transparent basement membrane that encapsulates the lens and is composed of a rigid network of interacting structural proteins and glycosaminoglycans. During cataract surgery, the anterior lens capsule is routinely removed in the form of a circular disk. We considered that the excised capsule could be easily prepared for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry imaging (MALDI-MSI) analysis. MALDI-MSI is a powerful tool to elucidate the spatial distribution of small molecules, peptides, and proteins within tissues. Here, we apply this molecular imaging technique to analyze the freshly excised human lens capsule en face. We demonstrate that novel information about the distribution of proteins by MALDI-MSI can be obtained from this highly compact connective tissue, having no evident histo-morphological characteristics. Trypsin digestion carried out on-tissue is shown to improve MALDI-MSI analysis of human lens capsules and affords high repeatability. Most importantly, MALDI-MSI analysis reveals a concentric distribution pattern of proteins such as apolipoprotein E (ApoE) and collagen IV alpha-1 on the anterior surface of surgically removed lens capsule, which may indicate direct or indirect effects of environmental and mechanical stresses on the human ocular lens.

  8. Successful hardware-in-the-loop support of the Longbow/HELLFIRE modular missile system

    Science.gov (United States)

    Ray, Jerry A.; Larson, Gerald A.; Terry, John E.

    2000-07-01

    The Air-to-Ground Missiles Systems (AGMS) Project Management Office (PMO) chose to invest in hardware-in-the-loop (HWIL) simulation as an integral part of their Longbow/HELLFIRE (Helicopter Launched, Fire-and-Forget) Modular Missile System program throughout the development and production phases. This investment has resulted in two HWIL simulations, developed by the U.S. Army Aviation and Missile Command (AMCOM) Missile Research Development and Engineering Center, that have had unprecedented success in program support from the early development through production phases. The Millimeter Simulation System 1 (MSS-1) facility is capable of edge-of- the-envelope performance analysis and verification using high- fidelity target, background, and countermeasures signature modeling. The System Test/Acceptance Facility (STAF), developed in partnership with Redstone Technical Test Center, tests full-up missiles for production lot acceptance. Between these two facilities, HWIL simulation is responsible for pre- flight confidence testing of missile hardware and software, software independent verification and validation (IV&V) testing, comprehensive performance evaluation, component verification, production lot acceptance, and data gathering for the shelf life extension program. One payoff of the MSS-1 HWIL investment has been an extremely effective flight test program with MSS-1 receiving credit for saving three flight tests and documenting over 40 failure modes. With the advent of the Performance Based Specification, the MSS-1 has become involved in continuous verification of high level specifications since contractor controlled, low-level specifications are subject to change. The STAF has saved 8 million annually through providing a non-destructive lot acceptance-testing paradigm, and further benefited the production phase by discovering three production problems. This paper will highlight the innovative uses of HWIL simulation as utilized in the Longbow/HELLFIRE program and

  9. Integrated Guidance and Control of Homing Missiles Against Ground Fixed Targets

    Institute of Scientific and Technical Information of China (English)

    Hou Mingzhe; Duan Guangren

    2008-01-01

    This paper presents a scheme of integrated guidance and autopilot design for homing missiles against ground fixed targets. An in- tegrated guidance and control model in the pitch plane is formulated and further changed into a normal form by nonlinear coordinate transformation. By adopting the sliding mode control approach, an adaptive nonlinear control law of the system is designed so that the missile can hit the target accurately with a desired impact attitude angle. The stability analysis of the closed-loop system is also con- ducted. The numerical simulation has confirmed the usefulness of the proposed design scheme.

  10. NATO and U.S. Ballistic Missile Defense Programs: Divergent or Convergent Paths?

    Science.gov (United States)

    2008-12-01

    making framework. It is common for TMD systems to be developed and deployed via bilateral negotiations. The only TMD project that has been subject to...sol-air moyenne portée- terrestre , that is, a ground based surface- to-air medium-range missile. 52 “Aster 30 SAMP/T – Surface-to-Air Missile Platform...alone rather than via a joint development with Alliance members that have expressed interest. Additionally, some European members of the Alliance

  11. Key considerations in infrared simulations of the missile-aircraft engagement

    CSIR Research Space (South Africa)

    Willers, MS

    2012-09-01

    Full Text Available of these details are investigated in Section 6. The tactical missile system used against aircraft includes several subsystems: airframe, flight control, fuze, propulsion, telemetry, data link, warhead and seeker.4 The seeker of an imaging IR missile provides...://proceedings.spiedigitallibrary.org/ on 12/19/2012 Terms of Use: http://spiedl.org/terms /7 dual mode detectors view a scene in two separate bands of the spectrum. The seeker compares the spectral distribution ratio of the various targets in the field of view to a predefined threshold. If a...

  12. [Bioequivalence research of cyclosporin soft capsules].

    Science.gov (United States)

    Wu, Yue; Mao, Mian; Wang, Ling; Jiang, Xuehua

    2012-04-01

    This paper is aimed to study the bioavailability and bioequivalence of Cyclosporin Soft Capsules (test preparation and reference preparation) in Chinese healthy volunteers. A high performance liquid chromatography-ultraviolet (HPLC-UV) method for determining the concentration of Cyclosporin A in human whole blood was developed and methodological validated. In accordance with the randomized two-period self crossover study, 24 volunteers received a single oral dose of 400 mg of test preparation or reference preparation. Multiple blood samples were collected post dose and then the concentration of Cyclosporin A in human whole blood samples was determined using the validated assay. The pharmacokinetic parameters including AUC0-t, Cmax, Tmax, and T1/2 were calculated using the non-compartmental method. The bioequivalence of the two preparations was evaluated. After receiving single dose of 400 mg of Cyclosporine A, the pharmacokinetic parameters of T1/2, Cmax, Tmax, and AUC0-t, of Cyclosporin A were (10.114 +/- 6.329) h and (9.717 +/- 4.076) h, (2021.235 +/- 298.581) ng x ml(-1) and (1992.192 +/- 1286.923) ng x ml(-1) (1.729 +/- 0.361) h and (1.813 +/- 0.323) h, (9824.811 +/- 1633.026) ng x h x ml(-1) and (10316.514 +/- 1395.955) ng x h x ml(-1) for test preparation and reference preparation, respectively. The statistical results suggested that these parameters were comparable between the two preparations. The results showed that the test preparation was bioequivalent with the reference preparation in healthy volunteers.

  13. Electrotherapy modalities for adhesive capsulitis (frozen shoulder).

    Science.gov (United States)

    Page, Matthew J; Green, Sally; Kramer, Sharon; Johnston, Renea V; McBain, Brodwen; Buchbinder, Rachelle

    2014-10-01

    Adhesive capsulitis (also termed frozen shoulder) is a common condition characterised by spontaneous onset of pain, progressive restriction of movement of the shoulder and disability that restricts activities of daily living, work and leisure. Electrotherapy modalities, which aim to reduce pain and improve function via an increase in energy (electrical, sound, light, thermal) into the body, are often delivered as components of a physical therapy intervention. This review is one in a series of reviews which form an update of the Cochrane review 'Physiotherapy interventions for shoulder pain'. To synthesise the available evidence regarding the benefits and harms of electrotherapy modalities, delivered alone or in combination with other interventions, for the treatment of adhesive capsulitis. We searched CENTRAL, MEDLINE, EMBASE, CINAHL Plus and the ClinicalTrials.gov and World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) clinical trials registries up to May 2014, unrestricted by language, and reviewed the reference lists of review articles and retrieved trials to identify any other potentially relevant trials. We included randomised controlled trials (RCTs) and controlled clinical trials using a quasi-randomised method of allocation that included adults with adhesive capsulitis and compared any electrotherapy modality to placebo, no treatment, a different electrotherapy modality, or any other intervention. The two main questions of the review focused on whether electrotherapy modalities are effective compared to placebo or no treatment, or if they are an effective adjunct to manual therapy or exercise (or both). The main outcomes of interest were participant-reported pain relief of 30% or greater, overall pain, function, global assessment of treatment success, active shoulder abduction, quality of life, and the number of participants experiencing any adverse event. Two review authors independently selected trials for inclusion

  14. Analytical Quality check of oil based blend in Flaxilip capsule

    Directory of Open Access Journals (Sweden)

    Rajashree Rane

    2014-12-01

    Full Text Available Analysis of capsules containing blend in the powder form is easy, but it is bit difficult to analyse the soft gelatin capsule containing oil based blend. The purpose of this study was to develop test parameters to determine and supervise the quality of such herbal capsule formulation. Five different lots of soft gelatin Flaxilip capsule containing Linseed oil, Guggulu processed with linseed oil, Garlic oil, Fenugreek oil along with Soyabean oil as an excipient , were selected for the study. All the five lots were subjected to general capsule tests such as determination of average weight and disintegration time. Results obtained were around 1.3500g and 10minutes respectively. Specific test parameters applicable for oils like specific gravity, refractive index, acid value, peroxide value, saponification value, iodine value were applied quantitatively for quality evaluation. Standardised suitable classical methods were applied. Results in all the five lots were found to be well within inhouse limit. All the samples were subjected to heavy metals and microbiological testing. Compliance of corresponding findings with the standard pharmacopoeial guidelines assure the safe intake of the drug. For getting the better effect, the Guggulu that is Commiphora mukul used in the formulation was processed with linseed oil. Its presence was confirmed by carrying out HPTLC for E and Z guggulu sterone. Resemblance of spots at Rf ranging from 0.36 to 0.38 and 0.43 to 0.45 in Toluene : Acetone (9:1 system showed the presence of gugulu in blends of all the lots. Hence by applying all these test parameters one can ensure the quality of the soft gelatin ayurvedic capsule formulation containing oily base like in Flaxilip capsule.

  15. Capsule endoscopy in the diagnosis of Crohn’s disease

    Directory of Open Access Journals (Sweden)

    Niv Y

    2013-05-01

    Full Text Available Yaron NivDepartment of Gastroenterology, Rabin Medical Center, Tel Aviv University, Petah Tikva, IsraelAbstract: Crohn’s disease is a chronic inflammatory disorder affecting any part of the gastrointestinal tract, but frequently involves the small and large bowel. Typical presenting symptoms include abdominal pain and diarrhea. Patients with this disorder may also have extraintestinal manifestations, including arthritis, uveitis, and skin lesions. The PillCam™SB capsule is an ingestible disposable video camera that transmits high quality images of the small intestinal mucosa. This enables the small intestine to be readily accessible to physicians investigating for the presence of small bowel disorders, such as Crohn’s disease. Four meta-analyses have demonstrated that capsule endoscopy identifies Crohn’s disease when other methods are not helpful. It should be noted that it is the best noninvasive procedure for assessing mucosal status, but is not superior to ileocolonoscopy, which remains the gold standard for assessment of ileocolonic disease. Mucosal healing along the small bowel can only be demonstrated by an endoscopic procedure such as capsule endoscopy. Achievement of long-term mucosal healing has been associated with a trend towards a decreased need for hospitalization and a decreased requirement for corticosteroid treatment in patients with Crohn’s disease. Recently, we have developed and validated the Capsule Endoscopy Crohn’s Disease Activity Index (also known as the Niv score for Crohn’s disease of the small bowel. The next step is to expand our score to the colon, and to determine the role and benefit of a capsule endoscopy activity score in patients suffering from Crohn’s ileocolitis and/or colitis. This scoring system will also serve to improve our understanding of the impact of capsule endoscopy, and therefore treatment, on the immediate outcome of this disorder. As the best procedure available for assessing

  16. Finding the solution for incomplete small bowel capsule endoscopy

    Institute of Scientific and Technical Information of China (English)

    José; Cotter; Francisca; Dias; de; Castro; Joana; Magalhes; Maria; Joo; Moreira; Bruno; Rosa

    2013-01-01

    AIM:To evaluate whether the use of real time viewer(RTV)and administration of domperidone to patients with delayed gastric passage of the capsule could reduce the rate of incomplete examinations(IE)and improve the diagnostic yield of small bowel capsule endoscopy(SBCE).METHODS:Prospective single center interventional study,from June 2012 to February 2013.Capsule location was systematically checked one hour after ingestion using RTV.If it remained in the stomach,the patient received 10 mg domperidone per os and the location of the capsule was rechecked after 30 min.If the capsule remained in the stomach a second dose of10 mg of domperidone was administered orally.After another 30 min the position was rechecked and if the capsule remained in the stomach,it was passed into the duodenum by upper gastrointestinal(GI)endoscopy.The rate of IE and diagnostic yield of SBCE were compared with those of examinations performed before the use of RTV or domperidone in our Department(control group,January 2009-May 2012).RESULTS:Both groups were similar regarding age,sex,indication,inpatient status and surgical history.The control group included 307 patients,with 48(15.6%)IE.The RTV group included 82 patients,with3(3.7%)IE,P=0.003.In the control group,average gastric time was significantly longer in patients with IE than in patients with complete examination of the small bowel(77 min vs 26 min,P=0.003).In the RTV group,the capsule remained in the stomach one hour after ingestion in 14/82 patients(17.0%)vs 48/307(15.6%)in the control group,P=0.736.Domperidone did not significantly affect small bowel transit time(260min vs 297 min,P=0.229).The capsule detected positive findings in 39%of patients in the control group and 49%in the RTV group(P=0.081).CONCLUSION:The use of RTV and selective administration of domperidone to patients with delayed gastric passage of the capsule significantly reduces incomplete examinations,with no effect on small bowel transit time or diagnostic yield.

  17. Pacific Missile Range Facility Intercept Test Support. Environmental Assessment/Overseas Environmental Assessment

    Science.gov (United States)

    2010-04-01

    Portable hair dryer 86 to 77 At 1 foot Vacuum cleaner 85 to 78 At 5 feet Long range airplane 80 to 70 Inside Conversation 60 Typical suburban...missile unstable, causing it to tumble and fall to the earth prior to reaching populated areas. Other strategies to cause a vehicle to tumble may also

  18. A Three-Pronged Strategy to Solve the Problem of Long-Range Missile Proliferation

    Science.gov (United States)

    1994-06-01

    One example is Brazil and its Sonda space launch vehicle (SLV) program. This SLV program, and others like it, are potentially dangerous to the U.S...because as a non-adherent to the MTCR, Brazil may transfer Sonda technology to rogue states or build offensive missiles capable of striking the U.S

  19. Treatment of open tibial fracture with bone defect caused by high velocity missiles: a case report.

    Science.gov (United States)

    Golubović, Zoran; Vukajinović, Zoran; Stojiljković, Predrag; Golubović, Ivan; Visnjić, Aleksandar; Radovanović, Zoran; Najman, Stevo

    2013-01-01

    Tibia fracture caused by high velocity missiles is mostly comminuted and followed by bone defect which makes their healing process extremely difficult and prone to numerous complications. A 34-year-old male was wounded at close range by a semi-automatic gun missile. He was wounded in the distal area of the left tibia and suffered a massive defect of the bone and soft tissue. After the primary treatment of the wound, the fracture was stabilized with an external fixator type Mitkovic, with convergent orientation of the pins. The wound in the medial region of the tibia was closed with the secondary stitch, whereas the wound in the lateral area was closed with the skin transplant after Thiersch. Due to massive bone defect in the area of the rifle-missile wound six months after injury, a medical team placed a reconstructive external skeletal fixator type Mitkovic and performed corticotomy in the proximal metaphyseal area of the tibia. By the method of bone transport (distractive osteogenesis), the bone defect of the tibia was replaced. After the fracture healing seven months from the secondary surgery, the fixator was removed and the patient was referred to physical therapy. Surgical treatment of wounds, external fixation, performing necessary debridement, adequate antibiotic treatment and soft and bone tissue reconstruction are essential in achieving good results in patients with the open tibial fracture with bone defect caused by high velocity missiles. Reconstruction of bone defect can be successfully treated by reconstructive external fixator Mitkovic.

  20. 78 FR 9768 - Bureau of International Security and Nonproliferation Imposition of Missile Sanctions on Two...

    Science.gov (United States)

    2013-02-11

    ... of International Security and Nonproliferation Imposition of Missile Sanctions on Two Chinese Foreign.... SUMMARY: A determination has been made that two foreign persons in China have engaged in activities that...) . Accordingly, the following sanctions are being imposed on these foreign persons for two years: (A) Denial of...

  1. Military aircraft and missile technology at the Langley Research Center: A selected bibliography

    Science.gov (United States)

    Maddalon, D. V.

    1980-01-01

    A compilation of reference material is presented on the Langley Research Center's efforts in developing advanced military aircraft and missile technology over the past twenty years. Reference material includes research made in aerodynamics, performance, stability, control, stall-spin, propulsion integration, flutter, materials, and structures.

  2. 76 FR 4322 - Availability of the Fiscal Year 2009 Missile Defense Agency Services Contracts Inventory Pursuant...

    Science.gov (United States)

    2011-01-25

    ... of the Secretary Availability of the Fiscal Year 2009 Missile Defense Agency Services Contracts... United States Code as amended by the National Defense Authorization Act for Fiscal Year 2008 (NDAA 08... Procurement and Acquisition Policy, Office of Strategic Sourcing (DPAP/SS) will make available to the public...

  3. Software Acquisition: Evolution, Total Quality Management, and Applications to the Army Tactical Missile System.

    Science.gov (United States)

    presents the concept of software Total Quality Management (TQM) which focuses on the entire process of software acquisition, as a partial solution to...software TQM can be applied to software acquisition. Software Development, Software Acquisition, Total Quality management (TQM), Army Tactical Missile

  4. 78 FR 42430 - Revisions to the Export Administration Regulations Based on the 2012 Missile Technology Control...

    Science.gov (United States)

    2013-07-16

    ... (Definitions of Terms as Used in the Export Administration Regulations) by amending the definition of the term... Definitions of terms as used in the Export Administration Regulations (EAR). * * * * * Payload... Administration Regulations Based on the 2012 Missile Technology Control Regime Plenary Agreements AGENCY:...

  5. ORAL HEALTH OF OPERATING FLEET BALLISTIC MISSILE SUBMARINE CREWS: A CROSS-SECTIONAL SURVEY.

    Science.gov (United States)

    A cross-sectional survey of two fleet ballistic missile submarine crews revealed no remarkable oral health factors. A close relationship was found...effects of FBM submarine service on oral health could be demonstrated; however, in view of the isolated nature of the FBM patrols great stress needs to

  6. The Effects of Fleet Ballistic Missile Submarine Patrols on Oral Health

    Science.gov (United States)

    Maintenance of optimum oral health for Fleet Ballistic Missile submarine personnel is a continuing effort. Information is required concerning oral ... health status and patrol effects on this status. Ninety-one crew members of the USS JOHN MARSHALL (SSBN 611 (Gold)) were evaluated predeployment, during

  7. Joint Theater Missile Defense in Taiwan: Protecting United States Interests and Friends

    Science.gov (United States)

    2007-11-02

    people in a disproportionately short period and where the consequences of its release overwhelms local responders. 67 APPENDIX A CHINESE BALLISTIC...2004, Ballistic Missile Defense. Airborne Laser The Airborne Laser (ABL) consists of a high-energy, chemical oxygen iodine laser (COIL) mounted

  8. Theoretical and Experimental Methods in the Solution of Missile Nonlinear Roll Problems

    Science.gov (United States)

    1978-03-01

    directed towvard improving the science of free flight missile dynamics by investigating the nonlinear rolling motion phenomena *exhibitcd by firned ...3 3 Schematic of Basic Finner Model ......................... 7 4 Induced Rolling Moment vs Roll Orientation Angle for Basic Finner Model Measured in...28 27 Rotational Characteristics of Cruciform Rectangular Fins ....... ............................. 29 28 Wind Tunnel Model (Naval Academy

  9. Dynamic attack zone of air-to-air missile after being launched in random wind field

    Institute of Scientific and Technical Information of China (English)

    Hui Yaoluo; Nan Ying; Chen Shaodong; Ding Quanxin; Wu Shengliang

    2015-01-01

    A new concept is presented for air-to-air missile which is dynamic attack zone after being launched in random wind field. This new concept can be used to obtain the 4-dimensional (4-D) information regarding the dynamic envelope of an air-to-air missile at any flight time aimed at different flight targets considering influences of random wind, in the situation of flight fighters coop-erated with missiles fighting against each other. Based on an air-to-air missile model, some typical cases of dynamic attack zone after being launched in random wind field were numerically simulated. Compared with the simulation results of traditional dynamic envelope, the properties of dynamic attack zone after being launched are as follows. The 4-D dynamic attack zone after being launched is inside traditional maximum dynamic envelope, but its forane boundary is usually not inside tra-ditional no-escape dynamic envelope;Traditional dynamic attack zone can just be reliably used at launch time, while dynamic envelope after being launched can be reliably and accurately used dur-ing any flight antagonism time. Traditional envelope is a special case of dynamic envelope after being launched when the dynamic envelope is calculated at the launch time;the dynamic envelope after being launched can be influenced by the random wind field.

  10. Passive FOG IMU for short-range missile application: from qualification toward series production

    Science.gov (United States)

    Trommer, Gert F.; Mueller, R.; Opitz, S.

    1996-11-01

    An inertial measurement unit (IMU) with angular rate, angular increment and linear acceleration measurement systems for short range missile application is described. It consists of a three axis fiber optic gyroscope (FOG) cluster, three linear vibrating beam accelerometers and an electronics device for signal evaluation and data transmission via a serial transputer link. The FOG cluster is realized by means of a passive all-fiber open loop configuration. Due to the inherent optical phase shift of 3 by 3 couplers, completely passive operation near the quadrature point is achieved without the need for a non- reciprocal optical phase modulation in the fiber loop. Basing on that concept more than 50 rugged IMUs have been built for implementation into a short range air to air missile. Verification tests for flight clearance with stresses simulating air carriage and missile free flight environments have been computed. The operation under extreme vibration and shock environments without the use of vibration isolator fixings due to very tight requirements on data time delay has been demonstrated. The first telemetered missile firings have been performed successfully. The line- setup for large quantity series production is progressing. The implementation of the workstations for the integration of the IMU is finished. The production equipment for calibration and acceptance testing of IMUs in parallel allowing for a rate of more than 150 unit per month has been installed and will be operational in autumn this year.

  11. Optical flow based guidance system design for semi-strapdown image homing guided missiles

    Directory of Open Access Journals (Sweden)

    Huang Lan

    2016-10-01

    Full Text Available This paper focuses mainly on semi-strapdown image homing guided (SSIHG system design based on optical flow for a six-degree-of-freedom (6-DOF axial-symmetric skid-to-turn missile. Three optical flow algorithms suitable for large displacements are introduced and compared. The influence of different displacements on computational accuracy of the three algorithms is analyzed statistically. The total optical flow of the SSIHG missile is obtained using the Scale Invariant Feature Transform (SIFT algorithm, which is the best among the three for large displacements. After removing the rotational optical flow caused by rotation of the gimbal and missile body from the total optical flow, the remaining translational optical flow is smoothed via Kalman filtering. The circular navigation guidance (CNG law with impact angle constraint is then obtained utilizing the smoothed translational optical flow and position of the target image. Simulations are carried out under both disturbed and undisturbed conditions, and results indicate the proposed guidance strategy for SSIHG missiles can result in a precise target hit with a desired impact angle without the need for the time-to-go parameter.

  12. Space radiation studies at the White Sands Missile Range Fast Burst Reactor

    Science.gov (United States)

    Delapaz, A.

    1972-01-01

    The operation of the White Sands Missile Range Fast Burst Reactor is discussed. Space radiation studies in radiobiology, dosimetry, and transient radiation effects on electronic systems and components are described. Proposed modifications to increase the capability of the facility are discussed.

  13. Synthesis of robust feedback missile control strategies by using LMI techniques

    NARCIS (Netherlands)

    Trottemant, E.J.; Weiss, M.; Vermeulen, A.

    2009-01-01

    Robust programming, and more specific LMI techniques, have proven to be an extremely effective tool for the synthesis of missile guidance laws. The advantage of this model-based approach is that a large class of uncertainties can be taken into account and a robust guidance law is obtained. In this p

  14. Optimal linear-quadratic missile guidance laws with penalty on command variability

    NARCIS (Netherlands)

    Weiss, M.; Shima, T.

    2015-01-01

    This paper proposes a new approach to the derivation of homing guidance laws for interceptor missiles that makes use of linear-quadratic optimal control in a different manner than the traditional approaches. Instead of looking only for the minimization of the miss distance and the integral square of

  15. 75 FR 20520 - Revisions to the Export Administration Regulations Based on the 2009 Missile Technology Control...

    Science.gov (United States)

    2010-04-20

    ... turbo-compound engines. Accordingly, turbo-compound engines are not meant to be included within the... describe these engines. Additionally, turbo- compound engines are not a missile proliferation concern. This... December 10, 2009 (74 FR 65662). DATES: Effective Date: This rule is effective: April 20, 2010....

  16. 75 FR 28587 - Taking and Importing Marine Mammals; Taking Marine Mammals Incidental to Missile Launch...

    Science.gov (United States)

    2010-05-21

    ... incidents (e.g., search-and-rescue, fire-fighting, adverse weather conditions), which may require... mission objectives; (2) the Navy must limit launch activities during other pinniped pupping seasons... launch trajectory necessary to meet mission objectives; (3) the Navy must not launch missiles from...

  17. Determination of an Achievable Materiel Availability for the Joint Air-to-Ground Missile

    Science.gov (United States)

    2009-07-01

    to meet applied TAT metrics (use of FedEx, DHL , etc.). Sup- ply chain variances emerge under organic support, which are out of the control of the...can be a low priority, will vary depending on the mode and frequency of trips. Missiles in particular cannot be shipped commercially (FedEx, DHL etc

  18. 75 FR 58365 - Taking and Importing Marine Mammals; Taking Marine Mammals Incidental to Missile Launch...

    Science.gov (United States)

    2010-09-24

    .... Placement of the cameras would cause minimal disturbance to pinnipeds and would focus on a subgroup of... forward looking infrared (FLIR) HS-324 Command thermal imaging cameras for nighttime monitoring of pinnipeds before, during, and after each missile launch. Previously, no cameras were available for...

  19. Near Term Command and Control of Homeland Air and Missile Defense

    Science.gov (United States)

    2003-01-01

    grounded the aircraft prior to take off. Special Operations forces might be best suited to eliminate a terrorist cell with minimal collateral 32 damage. We...Review. 27 March 2002. HAER No. ND-9 (Excerpt from Historic American Engineering Record,) Safeguard Ballistic Missile Defense Center ( BMDC ). Heller

  20. Navy Aegis Ballistic Missile Defense (BMD) Program: Background and Issues for Congress

    Science.gov (United States)

    2016-10-25

    developments in Australia, Japan , and South Korea. 93 Justin Doubleday, “MDA Looking to Integrate European Allies into Missile Defense Architecture ...12 Japan ................................................................................................................................. 12 Other...building, or are planning to build Aegis-equipped ships include Japan , South Korea, Australia, Spain, and Norway.2 Aegis BMD System3 Aegis ships

  1. Adaptive block dynamic surface control for integrated missile guidance and autopilot

    Institute of Scientific and Technical Information of China (English)

    Hou Mingzhe; Liang Xiaoling; Duan Guangren

    2013-01-01

    A novel integrated guidance and autopilot design method is proposed for homing missiles based on the adaptive block dynamic surface control approach.The fully integrated guidance and autopilot model is established by combining the nonlinear missile dynamics with the nonlinear dynamics describing the pursuit situation of a missile and a target in the three-dimensional space.The integrated guidance and autopilot design problem is further converted to a state regulation problem of a time-varying nonlinear system with matched and unmatched uncertainties.A new and simple adaptive block dynamic surface control algorithm is proposed to address such a state regulation problem.The stability of the closed-loop system is proven based on the Lyapunov theory.The six degrees of freedom (6DOF) nonlinear numerical simulation results show that the proposed integrated guidance and autopilot algorithm can ensure the accuracy of target interception and the robust stability of the closed-loop system with respect to the uncertainties in the missile dynamics

  2. Conventional Prompt Global Strike and Long Range Ballistic Missiles: Background and Issues

    Science.gov (United States)

    2017-02-03

    Christopher P. Caves, “Subs May Serve Attack, Guided Missile Functions,” Navy Times, October 15, 2011, http://www.navytimes.com/news/2011/10/navy- dual -use...preliminary results show that the HTV-2 achieved controlled flight in the atmosphere before telemetry was lost nine minutes after liftoff. 72 Media

  3. Conventional Prompt Global Strike and Long-Range Ballistic Missiles: Background and Issues

    Science.gov (United States)

    2016-02-24

    2011/10/navy- dual -use-submarines-attack-guided-missile-101511w/ 46 U.S. Department of Defense, Major Budget Decisions Briefing From the Pentagon...According to DARPA, its preliminary results show that the HTV-2 achieved controlled flight in the atmosphere before telemetry was lost nine minutes after

  4. Novel capsules for potential theranostics of obscure gastrointestinal bleedings.

    Science.gov (United States)

    Çolak, Bayram; Şakalak, Hüseyin; Çavuşoğlu, Halit; Yavuz, Mustafa Selman

    2016-09-01

    Obscure gastrointestinal (GI) bleeding is identified as persistent or repeated bleeding from the gastrointestinal tract which could not be defined by conventional gastrointestinal endoscopy and radiological examinations. These GI bleedings are assessed through invasive diagnostic and treatment methods including enteroscopy, angiography and endoscopy. In addition, video capsule endoscopy (VCE) is a non-invasive method used to determine the location of the bleeding, however, this does not provide any treatment. Despite of these successful but invasive methods, an effective non-invasive treatment is desperately needed. Herein, we prepare non-invasive theranostic capsules to cure obscure GI bleeding. An effective theranostic capsule containing endothelin as the targeting agent, thrombin-fibrinogen or fibrin as the treating agent, and fluorescein dye as the diagnostic tool is suggested. These theranostic capsules can be administered orally in a simple and non-invasive manner without a risk of complication. By using these novel capsules, one can diagnose obscure GI bleeding with having a possibility of curing. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Regional material properties of the human hip joint capsule ligaments.

    Science.gov (United States)

    Hewitt, J; Guilak, F; Glisson, R; Vail, T P

    2001-05-01

    The hip joint capsule functions to constrain translation between the femur and acetabulum while allowing rotational and planar movements. Despite the crucial role it plays in the pathogenesis of hip instability, little is known about its biomechanical properties. The goal of this study was to determine the regional material properties of the iliofemoral and ischiofemoral ligaments of the capsule. Ten human cadaveric specimens of each ligament were tested to failure in tension. The stress at failure, strain at failure, strain energy density at failure, toe- and linear-region elastic moduli, and the Poisson's ratio were measured for each ligament. The strain to failure was greatest in the ischiofemoral ligament, while no significant difference was noted in failure stress by region or ligament. The Young's moduli of elasticity ranged from 76.1 to 285.8 MPa among the different ligaments, and were generally consistent with properties previously reported for the shoulder capsule. The elastic moduli and strain energy density at failure differed by region. No significant differences in Poisson's ratio were found by region or ligament. The average Poisson's ratio was approximately 1.4, consistent with anisotropic behavior of ligamentous tissues. Understanding the material properties of the hip capsule may help the orthopaedic surgeon better understand normal ligament function, and thereby choose a surgical approach or strategy of repair. Furthermore, knowledge of the normal mechanical function of the hip capsule ligaments could assist in the evaluation of the success of a repair.

  6. Indications of capsule endoscopy in Crohn´s disease.

    Science.gov (United States)

    Luján-Sanchis, Marisol; Sanchis-Artero, Laura; Suárez-Callol, Patricia; Medina-Chuliá, Enrique

    2014-01-01

    Capsule endoscopy currently plays a relevant role for Crohn´s disease. This manuscript will discuss the current indications and practical uses of capsule endoscopy in this disease. It is a non-invasive technique that represents a significant advance in the endoscopic diagnosis of small bowel conditions. These circumstances, together with its diagnostic yield and excellent tolerability, make it considerably acceptable by both patients and physicians. This paper discusses the current evidence on the specific circumstances where capsule endoscopy may be indicated for three specific scenarios: Suspected Crohn´s disease, indeterminate colitis, and established Crohn´s disease, where it plays an extensive role. Furthermore, the impact and implications of capsule endoscopy results for follow-up are reviewed. These recommendations must be interpreted and applied in the setting of the integral, individual management of these patients. Understanding its appropriate use in daily clinical practice and an analysis of results may define endoscopic scoring systems to assess activity and mucosal healing in this condition. The present role of capsule endoscopy for Crohn´s disease is subject to ongoing review, and appropriate usage uncovers novel applications likely to result in relevant changes for the future management of these patients.

  7. Thermohydraulic design of saturated temperature capsule for IASCC irradiation test

    Energy Technology Data Exchange (ETDEWEB)

    Ide, Hiroshi; Matsui, Yoshinori; Itabashi, Yukio [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment] [and others

    2002-10-01

    An advanced water chemistry controlled irradiation research device is being developed in JAERI, to perform irradiation tests for irradiation assisted stress corrosion cracking (IASCC) research concerned with aging of LWR. This device enables the irradiation tests under the water chemistry condition and the temperature, which simulate the conditions for BWR core internals. The advanced water chemistry controlled irradiation research device is composed of saturated temperature capsule inserted into the JMTR core and the water chemistry control unit installed in the reactor building. Regarding the saturated temperature capsule, the Thermohydraulic design of capsule structure was done, aimed at controlling the specimen's temperature, feeding water velocity on specimen's surface to the environment of BWR nearer. As the result of adopting the new capsule structure based on the design study, it was found out that feeding water velocity at the surface of specimen's is increased to about 10 times as much as before, and nuclear heat generated in the capsule components can be removed safely even in the abnormal event such as the case of loss of feeding water. (author)

  8. Implantable telemetry capsule for monitoring arterial oxygen saturation and heartbeat.

    Science.gov (United States)

    Kuwana, K; Dohi, T; Hashimoto, Y; Matsumoto, K; Shimoyama, I

    2008-01-01

    In this study, we have developed an implantable telemetry capsule for monitoring heartbeat. The capsule has three main functions, monitoring vital signs, transmitting the vital signs, and receiving energy for driving the capsule without wires. We used two wavelengths of LEDs and a photodiode sensitive to the two wavelengths for heartbeat sensor. The arterial oxygen saturation is calculated from the amplitude of the heartbeat signal. We fabricated an FM transmitter whose carrier frequency was 80 MHz. Though the GHz range frequency is generally used in transmission, the attenuation in the human body is large. The size of a common linear antenna is about a quarter of its operating wavelength. We employed a coil-based antenna which can reduce size below the quarter of the wavelength. We fabricated a miniaturized transmitter with the coil-based antenna at lower frequency. Our capsule was driven intermittently. We used a rechargeable battery. When the battery ran down, the battery was charged by wireless using the induced electromotive force. This means that the capsule is capable of monitoring vital signs over the long term. We measured the heartbeat from the middle finger of hand in a water tank as a model of a human body.

  9. Cuttlefish capsule: An effective shield against contaminants in the wild.

    Science.gov (United States)

    Rosa, Inês C; Raimundo, Joana; Lopes, Vanessa M; Brandão, Cláudio; Couto, Ana; Santos, Catarina; Cabecinhas, Adriana S; Cereja, Rui; Calado, Ricardo; Caetano, Miguel; Rosa, Rui

    2015-09-01

    Increasing anthropogenic pressures in estuaries are responsible for the rise of contaminants in several compartments of these ecosystems. Species that benefit from the nursery services provided by estuaries are exposed to such contaminants (e.g. metals and metalloids). It is therefore relevant to understand if marine invertebrates that use these areas as spawning grounds accumulate contaminants in their tissues throughout embryogenesis. This study aimed to quantify As, Co, Cr, Cu, Mn, Ni, Se, Pb, V and Zn concentrations in both capsule and embryos of the common cuttlefish (Sepia officinalis) in Sado Estuary (Portugal). Moreover, embryos at their initial, intermediate and final stage of development were collected in sites subjected to different anthropogenic pressures. In general, the capsule accumulated higher element concentration throughout embryogenesis which indicates that the capsule acts as an effective barrier against contaminants uptake by the embryo. Although the capsule becomes thinner throughout embryogenesis, embryo's protection does not seem to be compromised at later development stages. Additionally, the higher concentrations of As, Cu, Se and Zn in the embryo in comparison to the capsule suggests important biological roles during the embryogenesis of this cephalopod mollusc. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. The effect of glicerol and sorbitol plasticizers toward disintegration time of phyto-capsules

    Science.gov (United States)

    Pudjiastuti, Pratiwi; Hendradi, Esti; Wafiroh, Siti; Harsini, Muji; Darmokoesoemo, Handoko

    2016-03-01

    The aim of research is determining the effect of glycerol and sorbitol toward the disintegration time of phyto-capsules, originated capsules from plant polysaccharides. Phyto-capsules were made from polysaccharides and 0.5% (v/v) of glycerol and sorbitol of each. The seven capsules of each were determined the disintegration time using Erweka disintegrator. The mean of disintegration time of phyto-capsules without plasticizers, with glycerol and sorbitol were 25'30"; 45'15" and 35'30" respectively. The color and colorless gelatin capsules showed the mean of disintegration time 7'30" and 2'35" respectively.

  11. A safety review for irradiation test of the creep capsule(02S-08K)

    Energy Technology Data Exchange (ETDEWEB)

    Cho, M. S.; Seo, C. G.; Choi, M. H.; Choo, K. N.; Sohn, J. M.; Kang, Y. H.; Kim, B. G. [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    2004-07-01

    The creep capsule(02S-08K), which is aimed to confirm the design characteristics and the structural integrity, will be irradiated at the IR2 test hole in October, 2004. To review a safety in the irradiation test of the capsule, the reactivity effect in HANARO was analyzed and stress and temperatures on the capsule were estimated. In the abnormal operating condition during the test of the capsule, the effect exerted on the capsule outer body by leakage or breakage of the stress loading unit equipped in the capsule was analyzed.

  12. 基于HLA的导弹仿真系统%Missile simulation system based on HLA

    Institute of Scientific and Technical Information of China (English)

    王利; 赵振南; 张亮

    2013-01-01

    计算机仿真是解决导弹装备研发过程中遇到难题的有效方法.设计了基于高层体系结构(HLA)分布式协议的仿真框架,给出了搭建系统的实施方案,具体介绍了系统联邦成员的构成及功能,分析设计了主要联邦成员的对象类和交互类,最后给出了整个系统的仿真流程及主要代码实现.该系统是一个模块化、通用化、易扩展、形象直观的导弹仿真系统,可以进行多种想定条件下导弹飞行仿真和性能评估,为导弹装备的论证、定型、验证提供了支撑平台.%The computer simulation is an effective way to solve the missile R&D process problems encountered.The article designs the simulation framework based on High Level Architecture (HLA),gives out the build system solutions,introduces the structure and function of the system of the federal member,analyzes and designs the main federal members of the object class and interaction class,finally present the simulation process and code implementation of the entire system.The system is a modular,extensible,general-purpose,image intuitive missile simulation system,can do many kinds of scenario conditions missile flight simulation and performance evaluation for missile equipment,provides support platform for missile equipment demonstration,qualitative and verify.

  13. Effects of trichostatin A on human Tenon capsule fibroblast

    Directory of Open Access Journals (Sweden)

    Xiao-Yan Li

    2014-11-01

    Full Text Available AIM:To investigate the effect of trichostatin A(TSAon cell proliferation and the expressions of histone deacetylase 1(HDAC1and HDAC2 in cultured human Tenon capsule fibroblast(HTF.METHODS: Human Tenon capsule fibroblasts were cultured in vitro after glaucoma filtration surgery. The third to sixth passage of cell were treated by 600nmol/L TSA or none. Cell viability measured by MTT assay after 1, 2 and 3d respectively. The expressions of HDAC1 and HDAC2 were analyzed by Western blot 2d after TSA treatment.RESULTS: Compared to the control, cell viability decreased significantly after treatment with TSA at 1d(PCONCLUSION: TSA inhibits the proliferation of Tenon capsule fibroblast by inhibiting the expression of HDAC1 and HDAC2, and reduces subconjunctival scar formation.

  14. Noncovalent encapsulation of cobaltocenium inside resorcinarene molecular capsules.

    Science.gov (United States)

    Philip, Ivy; Kaifer, Angel E

    2005-03-04

    The encapsulation of cobaltocenium (Cob+) inside hexameric molecular capsules of two different resorcinarenes was investigated in dichloromethane solution. Both 1H NMR spectroscopic and voltammetric experiments clearly reveal that Cob+ experiences encapsulation. Diffusion coefficient measurements obtained from PGSE NMR experiments indicate that the molecular capsules exist in dichloromethane solution in the absence of any cations. Bound and free Cob+ ions undergo slow exchange on the NMR time scale, but the bound Cob+ ions rotate and/or tumble freely inside the molecular capsules. Under experimental conditions suitable for voltammetry the encapsulation of Cob+ depends on the nature of the supporting electrolyte. Tetraalkylammonium hexafluorophosphate, tetrafluoroborate, and perchlorate supporting electrolytes prevent the encapsulation of Cob+, while tetraalkylammonium chloride and bromide salts allow it. The nature of the tetraalkylammonium cation plays a smaller role in the encapsulation. Finally, the structure of the resorcinarene also factors into the overall stability of the molecular assembly.

  15. Swallowable Wireless Capsule Endoscopy: Progress and Technical Challenges

    Directory of Open Access Journals (Sweden)

    Guobing Pan

    2012-01-01

    Full Text Available Wireless capsule endoscopy (WCE offers a feasible noninvasive way to detect the whole gastrointestinal (GI tract and revolutionizes the diagnosis technology. However, compared with wired endoscopies, the limited working time, the low frame rate, and the low image resolution limit the wider application. The progress of this new technology is reviewed in this paper, and the evolution tendencies are analyzed to be high image resolution, high frame rate, and long working time. Unfortunately, the power supply of capsule endoscope (CE is the bottleneck. Wireless power transmission (WPT is the promising solution to this problem, but is also the technical challenge. Active CE is another tendency and will be the next geneion of the WCE. Nevertheless, it will not come true shortly, unless the practical locomotion mechanism of the active CE in GI tract is achieved. The locomotion mechanism is the other technical challenge, besides the challenge of WPT. The progress about the WPT and the active capsule technology is reviewed.

  16. Wzy-dependent bacterial capsules as potential drug targets.

    Science.gov (United States)

    Ericsson, Daniel J; Standish, Alistair; Kobe, Bostjan; Morona, Renato

    2012-10-01

    The bacterial capsule is a recognized virulence factor in pathogenic bacteria. It likely works as an antiphagocytic barrier by minimizing complement deposition on the bacterial surface. With the continual rise of bacterial pathogens resistant to multiple antibiotics, there is an increasing need for novel drugs. In the Wzy-dependent pathway, the biosynthesis of capsular polysaccharide (CPS) is regulated by a phosphoregulatory system, whose main components consist of bacterial-tyrosine kinases (BY-kinases) and their cognate phosphatases. The ability to regulate capsule biosynthesis has been shown to be vital for pathogenicity, because different stages of infection require a shift in capsule thickness, making the phosphoregulatory proteins suitable as drug targets. Here, we review the role of regulatory proteins focusing on Streptococcus pneumoniae, Staphylococcus aureus, and Escherichia coli and discuss their suitability as targets in structure-based drug design.

  17. Demonstration of bacteroides capsules by light microscopy and ultrastructural cytochemistry.

    Science.gov (United States)

    Strohm, H; Payne, C M; Ryan, K J

    1983-05-01

    Forty-six anaerobic gram-negative bacilli, including 26 members of the Bacteroides fragilis group (BFG), were examined for capsules by the India ink technic. Thirty-five were encapsulated, including all the BFG strains. As a follow-up, seven of these isolates and two previously studied reference strains (B. fragilis ATCC 23745 and Bacteroides vulgatus ATCC 8482) were examined for capsules by ultrastructural cytochemistry. Using the periodic acid thiocarbohydrazide silver proteinate (PATCSP) method of Thiéry, all the BFG examined were encapsulated. In addition to the reference strains, this included one strain of B. fragilis and four of Bacteroides thetaiotaomicron. One non-BFG strain showed no capsular material. Differences between these results and those reported previously with the ruthenium red technic may reflect species differences in the chemical composition of Bacteroides capsules.

  18. Controllable light capsules employing modified Bessel-Gauss beams

    CERN Document Server

    Gong, Lei; Zhao, Qian; Ren, Yuxuan; Qiu, Xingze; Zhong, Mincheng; Li, Yinmei

    2016-01-01

    We report, in theory and experiment, on a novel class of controlled light capsules with nearly perfect darkness, directly employing intrinsic properties of modified Bessel-Gauss beams. These beams are able to naturally create three-dimensional bottle-shaped region during propagation as long as the parameters are properly chosen. Remarkably, the optical bottle can be controlled to demonstrate various geometries through tuning the beam parameters, thereby leading to an adjustable light capsule. We provide a detailed insight into the theoretical origin and characteristics of the light capsule derived from modified Bessel-Gauss beams. Moreover, a binary digital micromirror device (DMD) based scheme is first employed to shape the bottle beams by precise amplitude and phase manipulation. Further, we demonstrate their ability for optical trapping of core-shell magnetic microparticles, which play a particular role in biomedical research, with holographic optical tweezers. Therefore, our observations provide a new rou...

  19. Inhibitive Effects of Quercetin on Rabbit Tenon Capsule Fibroblasts Proliferation

    Institute of Scientific and Technical Information of China (English)

    Su Liu; Lin Chen

    2005-01-01

    Purpose:To study the inhibitive effects of quercetin (QU) on the fibroblasts proliferation of rabbit Tenon's capsule and its mechanism.Methods: Cultured fibroblasts were exposed to different concentrations of QU solution and investigated by microculture tetrazolium (MTT) assay. The effect of QU was obser ved on cells cycle using the flow cytometer. Besults: QU can suppress the proliferation of rabbit Tenon's capsule fibroblasts in vitro and show a dose-time dependent tendency.Flow cytometer results showed 26.92% cell increase in G1 phase, 23.50% decrease in S phase and 3.42% decrease in G2 phase.Conclusions: QU can suppress the proliferation of rabbit Tenon's capsule fibroblasts in vitro and show a dose-time dependent tendency. QU may effect all phase of cell cycle and inhibit cell proliferation by inhibiting G1 phase transitting to S phase and G2 phase.

  20. Rayleigh Taylor Instability Growth in NIC Capsules with Engineered Defects

    Science.gov (United States)

    Peterson, K. J.; Hammel, B. A.; Suter, L. J.; Clark, D. S.; Farley, D. R.; Landen, O. L.; Scott, H.; Moreno, K.; Vesey, R. A.; Herrmann, M. C.; Nakhleh, C. W.; Golovkin, I.; Regan, S. P.; Epstein, R.

    2011-10-01

    In order to achieve thermonuclear burn and energy gain in ICF capsules, the growth of hydrodynamic instabilities must be understood and controlled. Experiments are planned to measure time dependent hydrodynamic instability growth of engineered defects on the surface of NIC capsules using x-ray radiography. We will present an analysis of synthetic radiography from 2D and 3D HYDRA simulations with various x-ray drive fluxes and show how these results will be used to assess code predictions of instability growth and mix. We will also discuss how these results correlate with capsule performance and observables from hot spot self emission imaging and Ge spectroscopy. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  1. Development of Beryllium-Copper Alloy Ignition Capsules

    Science.gov (United States)

    Cooley, Jason; Alexander, David; Thoma, Daniel; Field, Robert; Day, Robert; Cameron, Bernard; Nobile, Arthur; Rivera, Gerald; Kelly, Ann; Papin, Pallas; Schulze, Roland; Dauelsberg, Lawrence; Alexander, Neil; Galix, Remy

    2004-11-01

    Cu-doped Be capsules are being developed for ignition on the National Ignition Facility (NIF). Our fabrication approach is based on bonding of cylindrical parts containing precision machined hemispherical cavities, followed by machining an external spherical contour to produce a spherical shell. While we have demonstrated this approach, there are several key issues that need to be resolved before a shell meeting NIF specifications can be produced. These issues are synthesis of high purity small grain size Be0.9at%Cu alloy, formation of a strong hemishell bond that will allow the capsule to contain its 400 atm fill gas at room temperature, precision machining and polishing of the capsule to meet stringent specifications for surface finish and spherical quality, and filling with DT. In this paper we report on the progress that has been made in resolving these key issues.

  2. Trade study for the disposition of cesium and strontium capsules

    Energy Technology Data Exchange (ETDEWEB)

    Claghorn, R.D.

    1996-03-01

    This trade study analyzes alternatives for the eventual disposal of cesium and strontium capsules currently stored at the Waste Encapsulation and Storage Facility as by-product. However, for purposes of this study, it is assumed that at some time in the future, the capsules will be declared high-level waste and therefore will require disposal at an offsite geologic repository. The study considered numerous alternatives and selected three for detailed analysis: (1) overpack and storage at high-level waste canister storage building, (2) overpack at the high-level waste vitrification facility followed by storage at a high-level waste canister storage building, and (3) blend capsule contents with other high-level waste feed streams and vitrify at the high-level waste vitrification facility.

  3. Characterization of the Kingella kingae polysaccharide capsule and exopolysaccharide.

    Directory of Open Access Journals (Sweden)

    Kimberly F Starr

    Full Text Available Recent evidence indicates that Kingella kingae produces a polysaccharide capsule. In an effort to determine the composition and structure of this polysaccharide capsule, in the current study we purified capsular material from the surface of K. kingae strain 269-492 variant KK01 using acidic conditions to release the capsule and a series of steps to remove DNA, RNA, and protein. Analysis of the resulting material by gas chromatography and mass spectrometry revealed N-acetyl galactosamine (GalNAc, 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo, and galactose (Gal. Further analysis by NMR demonstrated two distinct polysaccharides, one consisting of GalNAc and Kdo with the structure →3-β-GalpNAc-(1→5-β-Kdop-(2→ and the other containing galactose alone with the structure →5-β-Galf-(1→. Disruption of the ctrA gene required for surface localization of the K. kingae polysaccharide capsule resulted in elimination of GalNAc and Kdo but had no effect on the presence of Gal in bacterial surface extracts. In contrast, deletion of the pamABCDE locus involved in production of a reported galactan exopolysaccharide eliminated Gal but had no effect on the presence of GalNAc and Kdo in surface extracts. Disruption of ctrA and deletion of pamABCDE resulted in a loss of all carbohydrates in surface extracts. These results establish that K. kingae strain KK01 produces a polysaccharide capsule with the structure →3-β-GalpNAc-(1→5-β-Kdop-(2→ and a separate exopolysaccharide with the structure →5-β-Galf-(1→. The polysaccharide capsule and the exopolysaccharide require distinct genetic loci for surface localization.

  4. Effect of small bowel preparation with simethicone on capsule endoscopy

    Institute of Scientific and Technical Information of China (English)

    You-hong FANG; Chun-xiao CHEN; Bing-ling ZHANG

    2009-01-01

    Background: Capsule endoscopy is a novel non-invasive method for visualization of the entire small bowel. The diagnostic yield of capsule endoscopy depends on the quality of visualization of the small bowel mucosa and its complete passage through the small bowel. To date, there is no standardized protocol for bowel preparation before capsule endoscopy. The addition ofsimethicone in the bowel preparation for the purpose of reducing air bubbles in the intestinal lumen had only been studied by a few investigators. Methods: Sixty-four participants were randomly divided into two groups to receive a bowel preparation of polyethylene glycol (PEG) solution (Group 1) and both PEG solution and simethicone (Group 2). The PEG solution and sime-thicone were taken the night before and 20 min prior to capsule endoscopy, respectively. Frames taken in the small intestine were examined and scored for luminal bubbles by two professional capsule endoscopists. Gastric emptying time and small bowel transit time were also recorded. Results: Simethicone significantly reduced luminal bubbles both in the proximal and distal small intes-tines. The mean time proportions with slight bubbles in the proximal and distal intestines in Group 2 were 97.1% and 99.0%, respectively, compared with 67.2% (P<0.001) and 68.8% (P<0.001) in Group 1. Simethicone had no effect on mean gastric emptying time, 32.08 min in Group 2 compared with 30.88 min in Group 1 (P=0.868), but it did increase mean small intestinal transit time from 227.28 to 281.84 min (P=0.003). Conclusion: Bowel preparation with both PEG and simethicone significantly reduced bubbles in the intestinal lumen and improved the visualization of the small bowel by capsule endoscopy without any side effects observed.

  5. First beryllium capsule implosions on the National Ignition Facility

    Science.gov (United States)

    Kline, J. L.; Yi, S. A.; Simakov, A. N.; Olson, R. E.; Wilson, D. C.; Kyrala, G. A.; Perry, T. S.; Batha, S. H.; Zylstra, A. B.; Dewald, E. L.; Tommasini, R.; Ralph, J. E.; Strozzi, D. J.; MacPhee, A. G.; Callahan, D. A.; Hinkel, D. E.; Hurricane, O. A.; Milovich, J. L.; Rygg, J. R.; Khan, S. F.; Haan, S. W.; Celliers, P. M.; Clark, D. S.; Hammel, B. A.; Kozioziemski, B.; Schneider, M. B.; Marinak, M. M.; Rinderknecht, H. G.; Robey, H. F.; Salmonson, J. D.; Patel, P. K.; Ma, T.; Edwards, M. J.; Stadermann, M.; Baxamusa, S.; Alford, C.; Wang, M.; Nikroo, A.; Rice, N.; Hoover, D.; Youngblood, K. P.; Xu, H.; Huang, H.; Sio, H.

    2016-05-01

    The first indirect drive implosion experiments using Beryllium (Be) capsules at the National Ignition Facility confirm the superior ablation properties and elucidate possible Be-ablator issues such as hohlraum filling by ablator material. Since the 1990s, Be has been the preferred Inertial Confinement Fusion (ICF) ablator because of its higher mass ablation rate compared to that of carbon-based ablators. This enables ICF target designs with higher implosion velocities at lower radiation temperatures and improved hydrodynamic stability through greater ablative stabilization. Recent experiments to demonstrate the viability of Be ablator target designs measured the backscattered laser energy, capsule implosion velocity, core implosion shape from self-emission, and in-flight capsule shape from backlit imaging. The laser backscatter is similar to that from comparable plastic (CH) targets under the same hohlraum conditions. Implosion velocity measurements from backlit streaked radiography show that laser energy coupling to the hohlraum wall is comparable to plastic ablators. The measured implosion shape indicates no significant reduction of laser energy from the inner laser cone beams reaching the hohlraum wall as compared with plastic and high-density carbon ablators. These results indicate that the high mass ablation rate for beryllium capsules does not significantly alter hohlraum energetics. In addition, these data, together with data for low fill-density hohlraum performance, indicate that laser power multipliers, required to reconcile simulations with experimental observations, are likely due to our limited understanding of the hohlraum rather than the capsule physics since similar multipliers are needed for both Be and CH capsules as seen in experiments.

  6. Silicone Oil Tamponade Combined with Lensectomy Preserving Anterior Lens Capsule

    Institute of Scientific and Technical Information of China (English)

    LuL; YangJ

    1999-01-01

    Purpose:To investigate the therapeutic effect and indicatio n of silicone oil tamponade combined with lensectomy preserving anterior lens capsule.Methods:Silicone oil tamponade combined with lensectomy preserving anterior lens capsule was performed in 33 cases (33 eyes)of high myopia ,proliferative vitroretinopathy(PVR)D grade and giant retinal tear(GRT).10 cases were onlyeye and 11 cases had harder nucleus of lens.The surgical methods included:1.smashing lens nucleus and lensectomy preserving complete anterior capsule;2,vitrectomy and membrane peeling;3,usage of liquid perfluorocarbin or retinotomy or drainage;4.silicone oil tamponade;5.postoperative Nd;YAG laser for anterior capsulectomy. Results:Follow-up time was 6 months or more in 29 cases.Total retinal reattachment was achieved in 22 cases,macular retinal reattachment in 5 cases.The visual acuity was 20/800 to 20/200 in 13 cases,20/100 to 20/50 in 12 cases.Visual acuity was significantly improved in GRT group(P<0.05).Complications included unexpected anterior capsule break intraoperatively,anterior capsule opacity,silicone oil emulsification and liquid perfluorocarbin remainig postoperatively.Conclusions:Silicone oil tamponade combined with lensectomy preserving anterior capsule was safe and can reduce the operative complications.The indications included:1.GRT complicated with high myopia;2,advanced PVR cases complicated with high myopia in which silicone oil must be used;3.severe lens opacity cases in which silicone oil must be used;4.complex retinal detachment of only ye.

  7. Chemical inhibition of bacterial protein tyrosine phosphatase suppresses capsule production.

    Science.gov (United States)

    Standish, Alistair J; Salim, Angela A; Zhang, Hua; Capon, Robert J; Morona, Renato

    2012-01-01

    Capsule polysaccharide is a major virulence factor for a wide range of bacterial pathogens, including Streptococcus pneumoniae. The biosynthesis of Wzy-dependent capsules in both gram-negative and -positive bacteria is regulated by a system involving a protein tyrosine phosphatase (PTP) and a protein tyrosine kinase. However, how the system functions is still controversial. In Streptococcus pneumoniae, a major human pathogen, the system is present in all but 2 of the 93 serotypes found to date. In order to study this regulation further, we performed a screen to find inhibitors of the phosphatase, CpsB. This led to the observation that a recently discovered marine sponge metabolite, fascioquinol E, inhibited CpsB phosphatase activity both in vitro and in vivo at concentrations that did not affect the growth of the bacteria. This inhibition resulted in decreased capsule synthesis in D39 and Type 1 S. pneumoniae. Furthermore, concentrations of Fascioquinol E that inhibited capsule also lead to increased attachment of pneumococci to a macrophage cell line, suggesting that this compound would inhibit the virulence of the pathogen. Interestingly, this compound also inhibited the phosphatase activity of the structurally unrelated gram-negative PTP, Wzb, which belongs to separate family of protein tyrosine phosphatases. Furthermore, incubation with Klebsiella pneumoniae, which contains a homologous phosphatase, resulted in decreased capsule synthesis. Taken together, these data provide evidence that PTPs are critical for Wzy-dependent capsule production across a spectrum of bacteria, and as such represents a valuable new molecular target for the development of anti-virulence antibacterials.

  8. Chemical inhibition of bacterial protein tyrosine phosphatase suppresses capsule production.

    Directory of Open Access Journals (Sweden)

    Alistair J Standish

    Full Text Available Capsule polysaccharide is a major virulence factor for a wide range of bacterial pathogens, including Streptococcus pneumoniae. The biosynthesis of Wzy-dependent capsules in both gram-negative and -positive bacteria is regulated by a system involving a protein tyrosine phosphatase (PTP and a protein tyrosine kinase. However, how the system functions is still controversial. In Streptococcus pneumoniae, a major human pathogen, the system is present in all but 2 of the 93 serotypes found to date. In order to study this regulation further, we performed a screen to find inhibitors of the phosphatase, CpsB. This led to the observation that a recently discovered marine sponge metabolite, fascioquinol E, inhibited CpsB phosphatase activity both in vitro and in vivo at concentrations that did not affect the growth of the bacteria. This inhibition resulted in decreased capsule synthesis in D39 and Type 1 S. pneumoniae. Furthermore, concentrations of Fascioquinol E that inhibited capsule also lead to increased attachment of pneumococci to a macrophage cell line, suggesting that this compound would inhibit the virulence of the pathogen. Interestingly, this compound also inhibited the phosphatase activity of the structurally unrelated gram-negative PTP, Wzb, which belongs to separate family of protein tyrosine phosphatases. Furthermore, incubation with Klebsiella pneumoniae, which contains a homologous phosphatase, resulted in decreased capsule synthesis. Taken together, these data provide evidence that PTPs are critical for Wzy-dependent capsule production across a spectrum of bacteria, and as such represents a valuable new molecular target for the development of anti-virulence antibacterials.

  9. First beryllium capsule implosions on the National Ignition Facility

    Energy Technology Data Exchange (ETDEWEB)

    Kline, J. L.; Yi, S. A.; Simakov, A. N.; Olson, R. E.; Wilson, D. C.; Kyrala, G. A.; Perry, T. S.; Batha, S. H.; Zylstra, A. B.; Dewald, E. L.; Tommasini, R.; Ralph, J. E.; Strozzi, D. J.; MacPhee, A. G.; Callahan, D. A.; Hinkel, D. E.; Hurricane, O. A.; Milovich, J. L.; Rygg, J. R.; Khan, S. F.; Haan, S. W.; Celliers, P. M.; Clark, D. S.; Hammel, B. A.; Kozioziemski, B.; Schneider, M. B.; Marinak, M. M.; Rinderknecht, H. G.; Robey, H. F.; Salmonson, J. D.; Patel, P. K.; Ma, T.; Edwards, M. J.; Stadermann, M.; Baxamusa, S.; Alford, C.; Wang, M.; Nikroo, A.; Rice, N.; Hoover, D.; Youngblood, K. P.; Xu, H.; Huang, H.; Sio, H.

    2016-05-01

    The first indirect drive implosion experiments using Beryllium (Be) capsules at the National Ignition Facility confirm the superior ablation properties and elucidate possible Be-ablator issues such as hohlraum filling by ablator material. Since the 1990s, Be has been the preferred Inertial Confinement Fusion (ICF) ablator because of its higher mass ablation rate compared to that of carbon-based ablators. This enables ICF target designs with higher implosion velocities at lower radiation temperatures and improved hydrodynamic stability through greater ablative stabilization. Recent experiments to demonstrate the viability of Be ablator target designs measured the backscattered laser energy, capsule implosion velocity, core implosion shape from self-emission, and in-flight capsule shape from backlit imaging. The laser backscatter is similar to that from comparable plastic (CH) targets under the same hohlraum conditions. Implosion velocity measurements from backlit streaked radiography show that laser energy coupling to the hohlraum wall is comparable to plastic ablators. The measured implosion shape indicates no significant reduction of laser energy from the inner laser cone beams reaching the hohlraum wall as compared with plastic and high-density carbon ablators. These results indicate that the high mass ablation rate for beryllium capsules does not significantly alter hohlraum energetics. In addition, these data, together with data for low fill-density hohlraum performance, indicate that laser power multipliers, required to reconcile simulations with experimental observations, are likely due to our limited understanding of the hohlraum rather than the capsule physics since similar multipliers are needed for both Be and CH capsules as seen in experiments.

  10. Small-bowel neoplasms in patients undergoing video capsule endoscopy

    DEFF Research Database (Denmark)

    Rondonotti, E; Pennazio, M; Toth, E

    2008-01-01

    BACKGROUND AND STUDY AIM: Small-bowel tumors account for 1% - 3% of all gastrointestinal neoplasms. Recent studies with video capsule endoscopy (VCE) suggest that the frequency of these tumors may be substantially higher than previously reported. The aim of the study was to evaluate the frequency...... findings. 55 patients underwent VCE as the third procedure after negative bidirectional endoscopy. The lesions were single in 89.5% of cases, and multiple in 10.5%. Retention of the capsule occurred in 9.8% of patients with small-bowel tumors. After VCE, 54/124 patients underwent 57 other examinations...

  11. Steady state heat transfer in ORR irradiation capsules. Part 2

    Energy Technology Data Exchange (ETDEWEB)

    Michel, R.C.; Michaels, S.L.; Wilkes, G.R.

    1976-04-26

    The mathematical model developed by Stiros for prediction of temperature profiles in ORR irradiation capsules was modified and a numerical solution obtained. A Fortran computer program was written to solve the generalized finite difference equations applied to a fixed lattice system superimposed on the capsule cross section. The Liebmann iterative method was employed. The solution accounts for changes in internal heat generation, thermal expansion, and thermal conductivity induced by both temperature and fluence. The computed temperatures deviated from actual experimental measurements in the fuel rods by less than 2.0 percent.

  12. Colon capsule endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.

    Science.gov (United States)

    Spada, C; Hassan, C; Galmiche, J P; Neuhaus, H; Dumonceau, J M; Adler, S; Epstein, O; Gay, G; Pennazio, M; Rex, D K; Benamouzig, R; de Franchis, R; Delvaux, M; Devière, J; Eliakim, R; Fraser, C; Hagenmuller, F; Herrerias, J M; Keuchel, M; Macrae, F; Munoz-Navas, M; Ponchon, T; Quintero, E; Riccioni, M E; Rondonotti, E; Marmo, R; Sung, J J; Tajiri, H; Toth, E; Triantafyllou, K; Van Gossum, A; Costamagna, G

    2012-05-01

    PillCam colon capsule endoscopy (CCE) is an innovative noninvasive, and painless ingestible capsule technique that allows exploration of the colon without the need for sedation and gas insufflation. Although it is already available in European and other countries, the clinical indications for CCE as well as the reporting and work-up of detected findings have not yet been standardized. The aim of this evidence-based and consensus-based guideline, commissioned by the European Society of Gastrointestinal Endoscopy (ESGE) is to furnish healthcare providers with a comprehensive framework for potential implementation of this technique in a clinical setting.

  13. A parametric study on ice formation inside a spherical capsule

    Energy Technology Data Exchange (ETDEWEB)

    Ismail, K.A.R.; Silva, T.M. da [Depto. de Engenharia Termica e de Fluidos - FEM-UNICAMP CP: 6122, CEP 13083-970, SP, Campinas (Brazil); Henriquez, J.R. [Depto. de Engenharia Mecanica - DEMEC, UFPE, CEP 50740-530, PE, Recife (Brazil)

    2003-09-01

    This paper reports the results of a numerical study on the heat transfer during the process of solidification of water inside a spherical capsule. The governing equations of the problem and associated boundary conditions were formulated and solved using a finite difference approach and a moving grid scheme. The model was optimized and the numerical predictions were validated by comparison with experimental results realized by the authors. The model was also used to investigate the effects of the size and material of the shell, initial temperature of the phase change material and the external temperature of the spherical capsule on the solidified mass fraction and the time for the complete solidification. (authors)

  14. Capsule implosions driven by dynamic hohlraum x-rays

    Science.gov (United States)

    Bailey, James

    2005-10-01

    Dynamic hohlraum experiments at the Z facility already implode capsules with up to 80 kJ absorbed x-ray energy. However, many challenging issues remain for ICF. The present experiments use diagnostic capsules to address two of these issues: symmetry measurement and control and building understanding of the capsule/hohlraum implosion system. A suite of x-ray spectrometers record time and space resolved spectra emitted by Ar tracer atoms in the implosion core, simultaneously from up to three different quasi-orthogonal directions. Comparing the results with simulation predictions provide severe tests of understanding. These data also can used to produce a tomographic reconstruction of the time resolved core temperature and density profiles. X-ray and neutron diagnostics are used to examine how the implosion conditions change as the capsule design changes. The capsule design changes include variations in CH wall thickness and diameter, Ge-doped CH shells, and SiO2 shells. In addition, a new campaign investigating Be capsule implosions is beginning. Be capsules may offer superior performance for dynamic hohlraum research and it may be possible to investigate NIF-relevant Be implosion issues such as the fill tube effects, sensitivity to columnar growth associated with sputtered Be capsule fabrication, and the effect of Cu dopants on implosion conditions. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the U.S. Dept. of Energy under contract No. DE-AC04-94AL85000. * In collaboration with G.A. Rochau, G.A. Chandler, S.A. Slutz, P.W. Lake, G. Cooper, G.S. Dunham, R.J. Leeper, R. Lemke, T.A. Mehlhorn, T.J. Nash, D.S. Nielsen, K. Peterson, C.L. Ruiz, D.B. Sinars, J. Torres, W. Varnum, Sandia; R.C. Mancini, T.J. Buris-Mog, UNR; I. Golovkin, J.J. MacFarlane, PRISM; A. Nikro, D. Steinman, J.D. Kilkenny, H. Xu, General Atomics; M. Bump, T.C. Moore, K-tech; D.G. Schroen, Schafer

  15. Mechanism of Erhuang capsule for treatment of multiple sclerosis.

    Science.gov (United States)

    Li, Kangning; Fan, Yongping; Yang, Tao; Wang, Lei

    2013-02-25

    Erhuang capsule, a typical formula based on traditional Chinese medicine theory, is widely used to ameliorate multiple sclerosis, inflammation and side effects of glucocorticoid treatment. Oligodendrocyte precursor cells are neural stem cells that are important for myelin repair and regeneration. In the present study, Erhuang capsule effectively improved clinical symptoms and neurological function scores, reduced mortality and promoted recovery of neurological functions of mice with experimental autoimmune encephalomyelitis. The mechanism of action involved significant increases in oligodendrocyte precursor cell proliferation in specific regions of the brain and spinal cord, increased oligodendrocyte lineage gene 2 expression and enhanced oligodendrocyte precursor cell differentiation.

  16. Mechanism of Erhuang capsule for treatment of multiple sclerosis☆

    Science.gov (United States)

    Li, Kangning; Fan, Yongping; Yang, Tao; Wang, Lei

    2013-01-01

    Erhuang capsule, a typical formula based on traditional Chinese medicine theory, is widely used to ameliorate multiple sclerosis, inflammation and side effects of glucocorticoid treatment. Oligodendrocyte precursor cells are neural stem cells that are important for myelin repair and regeneration. In the present study, Erhuang capsule effectively improved clinical symptoms and neurological function scores, reduced mortality and promoted recovery of neurological functions of mice with experimental autoimmune encephalomyelitis. The mechanism of action involved significant increases in oligodendrocyte precursor cell proliferation in specific regions of the brain and spinal cord, increased oligodendrocyte lineage gene 2 expression and enhanced oligodendrocyte precursor cell differentiation. PMID:25206695

  17. DC polarographic and spectrophotometric determination of ampicillin capsules.

    Science.gov (United States)

    Squella, J A; Nunez-Vergara, L J; Aros, M

    1980-09-01

    Polarographic and spectrophotometric methods are proposed for the determination of ampicillin in capsules. Acidic hydrolysis of ampicillin with 1% HCHO in 0.3N HCl yields a degradation product identified as 2-hydroxy-3-phenyl-6-methylpyrazine. This compound has a well defined UV absorption band at 380 nm and a polarographic wave at -0.55 V vs SCE, which can be used for analytical purposes. Individual capsule assays, composite assays, and recovery studies are described. The average recovery values and standard deviations (SD) for UV and polarographic determinations were 99.20% (SD 0.95) and 100.85% (SD 1.09), respectively.

  18. Preshot Predictions for Defect Induced Mix (DIME) Capsules

    Energy Technology Data Exchange (ETDEWEB)

    Bradley, Paul A. [Los Alamos National Laboratory; Krasheninnikova, Natalia S. [Los Alamos National Laboratory; Tregillis, Ian L. [Los Alamos National Laboratory; Schmitt, Mark J. [Los Alamos National Laboratory

    2012-07-31

    In this memo, we evaluate the most probable yield and other results for the Defect Induced Mix (DIME-12A) Polar Direct Drive (PDD) capsule-only shots. We evaluate the expected yield, bang time, burn averaged ion temperature, and the average electron temperature of the Ge line-emitting region. We also include synthetic images of the capsule backlit by Cu K-{alpha} emission (8.39 keV) and core self-emission synthetic images. This memo is a companion to the maximum credible yield memo (LA-UR-12-00287) published earlier.

  19. A novel localization method for noninvasive monitoring capsule

    Institute of Scientific and Technical Information of China (English)

    He Wenhui; Yan Guozheng; Jiang Pingping; Guo Xudong

    2006-01-01

    Noninvasive monitoring capsule for gastrointestinal tract can be swallowed by patient. It is of great importance for the physician to monitor the precise position of capsule in gastrointestinal tract. The authors investigated a novel method for it. Using three coils with DC current to excite magnetic field and one triaxial magnetoresistive sensor to measure the excited magnetic vectors, they tried to solve the problem.The authors provided the localization principle of the method and analyzed it by an experiment, too. The method may be applied in practice in the future though it is still immature now.

  20. Mechanism of Erhuang capsule for treatment of multiple sclerosis

    Institute of Scientific and Technical Information of China (English)

    Kangning Li; Yongping Fan; Tao Yang; Lei Wang

    2013-01-01

    Erhuang capsule, a typical formula based on traditional Chinese medicine theory, is widely used to ameliorate multiple sclerosis, inflammation and side effects of glucocorticoid treatment. Oligodendrocyte precursor cells are neural stem cells that are important for myelin repair and regeneration. In the present study, Erhuang capsule effectively improved clinical symptoms and neurological function scores, reduced mortality and promoted recovery of neurological functions of mice with experimental autoimmune encephalomyelitis. The mechanism of action involved significant increases in oligodendrocyte precursor cell proliferation in specific regions of the brain and spinal cord, increased oligodendrocyte lineage gene 2 expression and enhanced oligodendrocyte precursor cell differentiation.

  1. 77 FR 35985 - Determination That PARAPLATIN (Carboplatin) Injection and SUSTIVA (Efavirenz) Capsules Were Not...

    Science.gov (United States)

    2012-06-15

    ... SUSTIVA (Efavirenz) Capsules Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness AGENCY... (efavirenz) Capsule, 100 Bristol Myers Squibb. milligrams (mg). NDA 20-452 PARAPLATIN (carboplatin) Do...

  2. Influence of transverse reinforcement on perforation resistance of reinforced concrete slabs under hard missile impact

    Energy Technology Data Exchange (ETDEWEB)

    Orbovic, Nebojsa, E-mail: nebojsa.orbovic@cnsc-ccsn.gc.ca; Sagals, Genadijs; Blahoianu, Andrei

    2015-12-15

    This paper describes the work conducted by the Canadian Nuclear Safety Commission (CNSC) related to the influence of transverse reinforcement on perforation capacity of reinforced concrete (RC) slabs under “hard” missile impact (impact with negligible missile deformations). The paper presents the results of three tests on reinforced concrete slabs conducted at VTT Technical Research Centre (Finland), along with the numerical simulations as well as a discussion of the current code provisions related to impactive loading. Transverse reinforcement is widely used for improving the shear and punching strength of concrete structures. However, the effect of this reinforcement on the perforation resistance under localized missile impact is still unclear. The goal of this paper is to fill the gap in the current literature related to this topic. Based on similar tests designed by the authors with missile velocity below perforation velocity, it was expected that transverse reinforcement would improve the perforation resistance. Three slabs were tested under almost identical conditions with the only difference being the transverse reinforcement. One slab was designed without transverse reinforcement, the second one with the transverse reinforcement in form of conventional stirrups with hooks and the third one with the transverse reinforcement in form of T-headed bars. Although the transverse reinforcement reduced the overall damage of the slabs (the rear face scabbing), the conclusion from the tests is that the transverse reinforcement does not have important influence on perforation capacity of concrete slabs under rigid missile impact. The slab with T-headed bars presented a slight improvement compared to the baseline specimen without transverse reinforcement. The slab with conventional stirrups presented slightly lower perforation capacity (higher residual missile velocity) than the slab without transverse reinforcement. In conclusion, the performed tests show slightly

  3. Cooperative Monitoring Center Occasional Paper/4: Missile Control in South Asia and the Role of Cooperative Monitoring Technology

    Energy Technology Data Exchange (ETDEWEB)

    Kamal, N.; Sawhney, P.

    1998-10-01

    The succession of nuclear tests by India and Pakistan in May 1998 has changed the nature of their missile rivalry, which is only one of numerous manifestations of their relationship as hardened adversaries, deeply sensitive to each other's existing and evolving defense capabilities. The political context surrounding this costly rivalry remains unmediated by arms control measures or by any nascent prospect of detente. As a parallel development, sensible voices in both countries will continue to talk of building mutual confidence through openness to avert accidents, misjudgments, and misinterpretations. To facilitate a future peace process, this paper offers possible suggestions for stabilization that could be applied to India's and Pakistan's missile situation. Appendices include descriptions of existing missile agreements that have contributed to better relations for other countries as well as a list of the cooperative monitoring technologies available to provide information useful in implementing subcontinent missile regimes.

  4. Integrated guidance and control design for missile with terminal impact angle constraint based on sliding mode control

    Institute of Scientific and Technical Information of China (English)

    Peng Wu; Ming Yang

    2010-01-01

    Aimed at the guidance requirements of some missiles which attack targets with terminal impact angle at the terminal point,a new integrated guidance and control design scheme based on variable structure control approach for missile with terminal impact angle constraint is proposed.First,a mathematical model of an integrated guidance and control model in pitch plane is established,and then nonlinear transformation is employed to transform the mathematical model into a standard form suitable for sliding mode control method design.A sufficient condition for the existence of linear sliding surface is given in terms of linear matrix inequalities(LMIs),based on which the corresponding reaching motion controller is also developed.To verify the effectiveness of the proposed integrated design scheme,the numerical simulation of missile is made.The simulation results demonstrate that the proposed guidance and control law can guide missile to hit the target with desired impact angle and desired flight attitude angle simultaneously.

  5. Cellulose nanofiber/nanocrystal reinforced capsules: a fast and facile approach toward assembly of liquid-core capsules with high mechanical stability.

    Science.gov (United States)

    Svagan, Anna J; Musyanovych, Anna; Kappl, Michael; Bernhardt, Max; Glasser, Gunnar; Wohnhaas, Christian; Berglund, Lars A; Risbo, Jens; Landfester, Katharina

    2014-05-12

    Liquid-core capsules of high mechanical stability open up for many solid state-like applications where functionality depending on liquid mobility is vital. Herein, a novel concept for fast and facile improvement of the mechanical properties of walls of liquid-core capsules is reported. By imitating nature's own way of enhancing the mechanical properties in liquid-core capsules, the parenchyma plant cells found in fruits and vegetables, a blend of short cellulose nanofibers (capsule walls. The NFC/CNC blend was prepared from a new version of the classical wood pulp hydrolysis. The capsule shell consisted of a covalently (by aromatic diisocyanate) cross-linked NFC/CNC structure at the outer capsule wall and an inner layer dominated by aromatic polyurea. The mechanical properties revealed an effective capsule elastic modulus of 4.8 GPa at 17 wt % NFC/CNC loading, about six times higher compared to a neat aromatic polyurea capsule (0.79 GPa) and 3 orders of magnitude higher than previously reported capsules from regenerated cellulose (0.0074 GPa). The outstanding mechanical properties are ascribed to the dense nanofiber structure, present in the outer part of the capsule wall, that is formed by oriented NFC/CNC of high average aspect ratio (L/d ∼ 70) and held together by both covalent (urethane bonds) and physical bonds (hydrogen bonds).

  6. Gravimetric Analysis of Particulate Matter using Air Samplers Housing Internal Filtration Capsules

    OpenAIRE

    O'Connor, Sean; O'Connor, Paula Fey; Feng, H. Amy; Ashley, Kevin

    2014-01-01

    An evaluation was carried out to investigate the suitability of polyvinyl chloride (PVC) internal capsules, housed within air sampling devices, for gravimetric analysis of airborne particles collected in workplaces. Experiments were carried out using blank PVC capsules and PVC capsules spiked with 0,1 – 4 mg of National Institute of Standards and Technology Standard Reference Material® (NIST SRM) 1648 (Urban Particulate Matter) and Arizona Road Dust (Air Cleaner Test Dust). The capsules were ...

  7. Ballistic Missile Defense: Actions Needed to Address Implementation Issues and Estimate Long-Term Costs for European Capabilities

    Science.gov (United States)

    2014-04-01

    forces, and allies against inbound threat missiles. In December 2011, DOD deployed the initial phase of a revised approach for Europe, with...the United States, U.S. forces, and allies around the world against inbound threat missiles. In 2009, the President announced a revised approach for...allocating resources. In addition, we reviewed the Army’s regulation on Integrated Logistic Support, which includes guidance on business-case analysis

  8. A study of the motion and aerodynamic heating of ballistic missiles entering the earth's atmosphere at high supersonic speeds

    Science.gov (United States)

    Allen, H Julian; Eggers, A J , Jr

    1958-01-01

    A simplified analysis of the velocity and deceleration history of ballistic missiles entering the earth's atmosphere at high supersonic speeds is presented. The results of this motion analysis are employed to indicate means available to the designer for minimizing aerodynamic heating. The heating problem considered involves not only the total heat transferred to a missile by convection, but also the maximum average and local time rates of convective heat transfer.

  9. Research of Short-range Missile Motion in Terms of Different Wind Loads

    Directory of Open Access Journals (Sweden)

    A. N. Klishin

    2015-01-01

    Full Text Available When modeling the aircraft motion it is advisable to choose a particular model of the Earth, depending both on the task and on the required accuracy of calculation. The article describes various models of the Earth, such as the flat Earth with a plane-parallel field of gravity, spherical and non-rotating Earth with a plane-parallel field of gravity, spherical and non-rotating Earth with a central gravitational field, spherical and non-rotating Earth, taking into account the polar flattening of the Earth, spherical Earth based compression and polar daily rotation. The article also considers the influence of these models on the motion of the selected aircraft.To date, there is technical equipment to provide highly accurate description of the Earthshape, gravitational field, etc. The improved accuracy of the Earth model description results in more correct description of the trajectory and motion parameters of a ballistic missile. However, for short ranges (10-20 km this accuracy is not essential, and, furthermore, it increases time of calculation. Therefore, there is a problem of choosing the optimal description of the Earth parameters.The motion in the model of the Earth, which takes into account a daily rotation of the planet and polar flattening, is discussed in more detail, and the geographical latitude impact on coordinates of the points of fall of a ballistic missile is analyzed on the basis of obtained graphs.The article individually considers a problem of the wind effect on the aircraft motion and defines dependences of the missile motion on the parameters of different wind loads, such as wind speed and height of its action.A mathematical model of the missile motion was built and numerically integrated, using the Runge-Kutta 4th order method, for implementation and subsequent analysis.Based on the analysis of the calculation results in the abovementioned models of the Earth, differences in impact of these models on the parameters of the

  10. 75 FR 39024 - Determination That ACCUTANE (Isotretinoin) Capsules, 10 Milligrams, 20 Milligrams, and 40...

    Science.gov (United States)

    2010-07-07

    ... HUMAN SERVICES> Food and Drug Administration Determination That ACCUTANE (Isotretinoin) Capsules, 10... Administration (FDA) is announcing its determination that ACCUTANE (isotretinoin) Capsules, 10 milligrams (mg...) Capsules, 10 mg, 20 mg, and 40 mg, are the subject of NDA 18-662, held by Hoffman-La Roche, Inc. (Roche...

  11. No stabilizing effect of the elbow joint capsule. A kinematic study

    DEFF Research Database (Denmark)

    Nielsen, K K; Olsen, Bo Sanderhoff

    1999-01-01

    We dissected 7 cadaveric elbow specimens, leaving the collateral ligaments and the joint capsule intact. The anterior and the posterior capsule were sequentially transected, followed by kinematic testings. We found no change in joint laxity after total transection of the capsule....

  12. 10 CFR 32.21 - Radioactive drug: Manufacture, preparation, or transfer for commercial distribution of capsules...

    Science.gov (United States)

    2010-01-01

    ... for commercial distribution of capsules containing carbon-14 urea each for âin vivoâ diagnostic use..., preparation, or transfer for commercial distribution of capsules containing carbon-14 urea each for “in vivo... commercial distribution capsules containing 37 kBq (1 µCi) carbon-14 urea (allowing for nominal variation...

  13. 75 FR 76017 - Determination That GLEEVEC (Imatinib Mesylate) Capsules, 50 Milligrams and 100 Milligrams, Were...

    Science.gov (United States)

    2010-12-07

    ... HUMAN SERVICES Food and Drug Administration Determination That GLEEVEC (Imatinib Mesylate) Capsules, 50... determined that GLEEVEC (imatinib mesylate) Capsules, 50 milligrams (mg) and 100 mg, were not withdrawn from... new drug applications (ANDAs) for imatinib mesylate capsules, 50 mg and 100 mg, if all other legal and...

  14. 75 FR 52768 - Withdrawal of Approval of New Animal Drug Applications; Dichlorophene and Toluene Capsules

    Science.gov (United States)

    2010-08-27

    ...; Dichlorophene and Toluene Capsules AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food... use of dichlorophene and toluene deworming capsules for cats and dogs. In a final rule published... withdraw approval of NADA 101-497 for TINY TIGER (dichlorophene/toluene) Worming Capsules, NADA 101-498 for...

  15. Investigation on the aerosol performance of dry powder inhalation hypromellose capsules with different lubricant levels.

    Science.gov (United States)

    Saleem, I Y; Diez, F; Jones, B E; Kayali, N; Polo, L

    2015-08-15

    HPMC capsules are made by a dipping process and a surface lubricant for the mould pins is an essential processing aid for removing dried capsules shells. For the purpose of this study, the level was determined by quantifying methyloleate (MO) a component found in the lubricant but not in the hypromellose capsules. Here we investigated the influence of the lubricant, low (10.81 μg/capsule=60 mg/kg MO), medium (15.97 μg/capsule=90 mg/kg MO) and high (23.23 μg/capsule=127 mg/kg MO) content on powder (binary mixture of salbutamol: lactose, 1:50 w/w) aerosolization properties was investigated. Results indicated significantly lower emitted dose from capsules with 60 mg/kg MO. Furthermore, the 90 and 127 mg/kg MO level of lubricant capsules produced almost double the Fine Particle Dose & Fine Particle Fraction compared with the low level of lubricant. The data indicates that lubricant level within capsules has an influence on deposition profiles and amount of drug remaining in capsule and inhaler device after actuation. It is suggested lubricant levels greater than 60 mg/kg MO per capsule are required to minimise powder retention within capsules and maximise deposition profiles. AFM (atomic force microscopy) data suggest that internal surface roughness may be related with this phenomena. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

  16. 77 FR 53892 - Determination That ALOXI (Palonosetron Hydrochloride) Capsules, 0.5 Milligram (Base), Were Not...

    Science.gov (United States)

    2012-09-04

    ...) Capsules, 0.5 Milligram (Base), Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness AGENCY... determined that ALOXI (palonosetron hydrochloride (HCl)) Capsules, 0.5 milligram (mg) (base), were not... abbreviated new drug applications (ANDAs) for palonosetron HCl capsules, 0.5 mg (base), if all other legal and...

  17. 21 CFR 520.2345f - Tetracycline phosphate complex and sodium novobiocin capsules.

    Science.gov (United States)

    2010-04-01

    ... novobiocin capsules. 520.2345f Section 520.2345f Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... ANIMAL DRUGS § 520.2345f Tetracycline phosphate complex and sodium novobiocin capsules. (a) Specifications. Each capsule contains the equivalent of 60 milligrams of tetracycline hydrochloride and 60...

  18. 78 FR 1221 - Notice of Issuance of Final Determination Concerning Ponstel® (Mefenamic Acid) Capsules

    Science.gov (United States)

    2013-01-08

    ... (Mefenamic Acid) Capsules AGENCY: U.S. Customs and Border Protection, Department of Homeland Security. ACTION... acid) capsules. Based upon the facts presented, CBP has concluded in the final determination that India is the country of origin of the Ponstel (mefenamic acid) capsules for purposes of U.S. Government...

  19. 76 FR 59141 - Determination That LOXITANE (Loxapine Succinate) Capsules and Three Other Drug Products Were Not...

    Science.gov (United States)

    2011-09-23

    ... HUMAN SERVICES Food and Drug Administration Determination That LOXITANE (Loxapine Succinate) Capsules...., 417 Wakara Capsules, Way, Suite 100, Equivalent to (EQ) Salt Lake City, UT 5 milligram (mg) 84108...) Inc., 340 Kingsland Capsule, 200 mg. St., Nutley, NJ 07110. FDA has reviewed its records and, under...

  20. 77 FR 41412 - Determination That CHLOROMYCETIN (Chloramphenicol) Capsules, 250 Milligrams, Were Withdrawn From...

    Science.gov (United States)

    2012-07-13

    ... HUMAN SERVICES Food and Drug Administration Determination That CHLOROMYCETIN (Chloramphenicol) Capsules... CHLOROMYCETIN (chloramphenicol) Capsules, 250 milligrams (mg), were withdrawn from sale for reasons of safety or... chloramphenicol capsules, 250 mg. FOR FURTHER INFORMATION CONTACT: Nikki Mueller, Center for Drug Evaluation and...