WorldWideScience

Sample records for vliyanie intensivnoj plasticheskoj

  1. Vliyanie antigipertenzivnoy terapii na aktivnost' adipokinov i endotelina-1 u bol'nykh arterial'noy gipertoniey s ozhireniem

    Directory of Open Access Journals (Sweden)

    S D Oshorova

    2011-06-01

    Full Text Available The aim of the study was to investigate the pharmacodynamic characteristics of the modern antihypertensive therapy in obese hypertensive patients. Materials and methods. The activity of leptin, adiponectin and endothelin-1 and cardiohemodynamics were studied in 61 patients with essential hypertension and obesity (body mass index 34,3±4,8 kg/m2 before and after the 12-weeks treatment with zofenopril (n=31 and nebivolol (n=29. Results. It was revealed that obese hypertensive patients had abnormal circadian profile of blood pressure (63.9%, hyperleptinemia together with the decrease of the adiponectin activity (67%, as well as the increased activity of endothelin-1 (54%. The 12-weeks therapy with zofenopril and nebivolol has resulted in the improvement of the daily profile of the arterial pressure with the achievement of the target level of the arterial pressure in 72% and 79% of patients correspondingly. The following was recorded: the decrease in the activity of leptin and endothelin-1 in both groups; upward trend of the adiponectins activity under the influence of zofenopril. Conclusion. Zofenopril and nebivolol in obese hypertensive patients in addition to the antihypertensive action reduce negative cardiometabolic effects of the activation of adipocytes and endothelin-1.

  2. Metafora i (giperëkstensija

    Directory of Open Access Journals (Sweden)

    Radić Jovanka

    2008-01-01

    Full Text Available (ruski Termin 'ëkstensija' imeet gorazdo bolee opredelennoe značenie po sravneniju s terminom metafora: ëkstensija podrazumevaet sposobnost' vyraženija (obyčno leksičeski zavisimogo slova k rasšireniju i vyraženiju svojstv predmetov, kotorye nastol'ko različny po svoej prirode, čto isključena vsjakaja vozmožnost' podobija ljubogo iz ih svojstv (ide čovek, ~ paun, ~ lav, ~ ekser, ~ voda; meka maca, ~ igračka, ~ bunda, meke papuče meko krzno, meka kruška, ~ voda, i t. p. Ëkstensija, v ukazannom značenii svjazana s giperëkstensiej, a takže s metaforoj ne po analogii, t. e. s pervymi tremja 'vidami' metafory, vydelennymi v 'Poëtike' Aristotelja ('perenesenie naimenovanija s odnogo predmeta na drugoj, pričem ili s roda na vid, ili s vida na rod, ili s vida na vid'. Različie meždu (1 poëtičeskoj metaforoj ('ukrašenie', 'stilističeskaja figura', zamečaemoj potomu, čto ona osnovyvaetsja na sbliženii dvuh ponjatij po analogii i tem samym 'soobščaet novoe znanie' ili 'živo predstavljaet vešč'', i (2 metaforoj ne po analogii t. e. perenosom naimenovanija, kotoryj neograničenno i nezametno rasširjaetsja, t. k. on ne osnovan na ustanovlenii svjazej po analogii meždu predmetami (ponjatijnaja metafora - aspekt, kotoryj do nedavnego vremeni vključalsja v termin polisemija, - možno dostatočno točno oboznačit' pri pomošči terminov intensivnaja i ëkstensivnaja metafora, sostavljajuščih oppoziciju. Takim obrazom, možno govorit' ob ëkstensivnoj metafore, kotoraja razvivaetsja v širinu i nezametna, i ob intensivnoj metafore, kotoraja zamečaetsja, t. k. razvivaetsja ne v širinu, a v glubinu.