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Sample records for vinson phd nci

  1. Craig Reynolds, Ph.D., to Retire as NCI Associate Director for Frederick | Poster

    Science.gov (United States)

    On December 2, Craig Reynolds, Ph.D., director, Office of Scientific Operations, and NCI associate director for Frederick, will put the finishing touches on a 37-year career with the National Cancer Institute.

  2. Plummer-Vinson syndrome

    Directory of Open Access Journals (Sweden)

    Novacek Gottfried

    2006-09-01

    Full Text Available Abstract Plummer-Vinson or Paterson-Kelly syndrome presents as a classical triad of dysphagia, iron-deficiency anemia and esophageal webs. Exact data about epidemiology of the syndrome are not available; the syndrome is extremely rare. Most of the patients are white middle-aged women, in the fourth to seventh decade of life but the syndrome has also been described in children and adolescents. The dysphagia is usually painless and intermittent or progressive over years, limited to solids and sometimes associated with weight loss. Symptoms resulting from anemia (weakness, pallor, fatigue, tachycardia may dominate the clinical picture. Additional features are glossitis, angular cheilitis and koilonychia. Enlargement of the spleen and thyroid may also be observed. One of the most important clinical aspects of Plummer-Vinson syndrome is the association with upper alimentary tract cancers. Etiopathogenesis of Plummer-Vinson syndrome is unknown. The most important possible etiological factor is iron deficiency. Other possible factors include malnutrition, genetic predisposition or autoimmune processes. Plummer-Vinson syndrome can be treated effectively with iron supplementation and mechanical dilation. In case of significant obstruction of the esophageal lumen by esophageal web and persistent dysphagia despite iron supplementation, rupture and dilation of the web are necessary. Since Plummer-Vinson syndrome is associated with an increased risk of squamous cell carcinoma of the pharynx and the esophagus, the patients should be followed closely.

  3. Syndrome of Plummer-Vinson

    International Nuclear Information System (INIS)

    Rincon, Reinaldo A; Hani, Albis; Alvarado, Jaime

    2004-01-01

    A case of Syndrome of Plummer-Vinson is presented in a 38 year-old patient who consults for an eight year-old square, adinamia and paleness progressive; symptoms that are exacerbated in the last months and they are accompanied, of nine months of evolution, of progressive dysphagia for solids and during the last eight days of deposition with sensation of incomplete evacuation, abdominal distension and flatulence

  4. Plummer-Vinson Syndrome with Improvement After Iron Repletion

    African Journals Online (AJOL)

    10.4314/aas.v13i2.11. Introduction. Plummer-Vinson syndrome (synonyms: Paterson-. Kelly Syndrome, Paterson-Brown Kelly syndrome,. Sideropenic dysphagia), is defined by the classic triad of dysphagia, iron deficiency anemia and esophageal.

  5. Plummer-Vinson syndrome combined with arteria lusoria

    International Nuclear Information System (INIS)

    Prokopenko, O.P.

    1988-01-01

    Role of X-ray methods in diagnosis of Plummer-Vinson syndrome combined with arteria lusoria is described. X-ray patterns of esophagus illustrating its pathological changes are presented. Concrete recommendations for diagnosis of the above-mentioned disease in carrying out X-ray investigations are given

  6. Revisiting Plummer Vinson Syndrome | Gude | Annals of Medical ...

    African Journals Online (AJOL)

    Plummer Vinson syndrome is a rare association of postcricoid dysphagia, upper esophageal webs, and iron deficiency anemia. Iron deficiency state has been hypothesized to play an etiological role. While literature review elucidates the resolution of dysphagia in most cases with iron therapy, we discuss our case where the ...

  7. Iron deficiency anemia and Plummer–Vinson syndrome: current insights

    Directory of Open Access Journals (Sweden)

    Goel A

    2017-10-01

    Full Text Available Amit Goel,1 Satvinder Singh Bakshi,2 Neetu Soni,3 Nanda Chhavi4 1Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India; 2Department of Otorhinolaryngology and Head and Neck Surgery, Mahatma Gandhi Medical College and Research Institute, Puducherry, India; 3Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India; 4Department of Pediatrics, Era’s Lucknow Medical College, Lucknow, India Abstract: Plummer–Vinson syndrome (PVS, a rare clinical condition, is characterized by a triad of dysphagia, iron deficiency anemia and esophageal web in the post-cricoid region. It was first described over a century ago. However, literature on this condition remains scanty, and its prevalence appears to be declining worldwide, possibly due to improvements in nutrition over time. The condition has been reported most commonly in thin-built, middle-aged, white women. The esophageal webs in PVS are thin mucosal folds, which are best seen either in lateral views at barium swallow or at esophagoscopy. These are usually semilunar or crescentic, being located most often along the anterior esophageal wall, but can be concentric. The exact cause and pathogenesis of PVS remain unclear, though iron and other nutritional deficiencies, genetic predisposition and autoimmunity have all been implicated in formation of the webs. Treatment includes correction of iron deficiency and endoscopic dilation of the esophageal webs to relieve dysphagia. PVS is associated with an increased risk of hypopharyngeal and esophageal malignancies. Correction of iron deficiency may arrest and reverse the mucosal changes and possibly reduces this risk. Keywords: Plummer–Vinson syndrome, Paterson–Brown–Kelly syndrome, esophageal web, dysphagia, iron deficiency anemia

  8. Plummer Vinson syndrome in a male and his chromosomal study â ...

    African Journals Online (AJOL)

    Santosh K. Swain

    2015-05-08

    May 8, 2015 ... Abstract Plummer Vinson syndrome (PVS) is a triad of iron deficiency anemia, esophageal web and dysphagia. The exact etiology of PVS remains controversial but it has been associated with nutritional deficiency, autoimmune disorders, hereditary factors and remarkable high female pre- dominance.

  9. NCI & Division Obligations

    Science.gov (United States)

    Displays obligations for grants, contracts, training fellowships, intramural research, and management and support, including the number of grant awards, funding amounts, and percent of the total NCI budget.

  10. NCI Scientists Awarded National Medal of Technology and Innovation by President Obama | Poster

    Science.gov (United States)

    Two NCI scientists received the National Medal of Technology and Innovation, the nation’s highest honor for technological achievement. The award was announced by President Obama in October. The honorees, John Schiller, Ph.D., Laboratory of Cellular Oncology (LCO), Center for Cancer Research, NCI, and Douglas Lowy, M.D., also from LCO and NCI deputy director, received their medals at a White House ceremony on Nov. 20.

  11. VINSON/AUTOVON Interface Applique for the Modem, Digital Data, AN/GSC-38

    Science.gov (United States)

    1980-11-01

    assignment system for the RED audio cables. A subscriber handset is used at the VINSON CABINET for crypto key changes through an auxillary cable, but...go" decision regarding each test performed in Section 3 of ATP 13044. The numbering following 4.2 directly corresponds to the step in Section 3 in...which the data is collected. A.1 Test and Auxillary Equipment Required or Tested A.1.1 Test Equipment Manufacturer Model Nomenclature Serial Number

  12. NCI intramural research highlighted at 2014 AACR meeting

    Science.gov (United States)

    This year’s American Association for Cancer Research meeting featured plenary talks by two NCI scientists, Steven Rosenberg, M.D., and Louis Staudt, M.D., Ph.D., that highlighted the challenges in developing varied and potentially synergistic treatments f

  13. Robert Wiltrout Says Goodbye to NCI in 2015 | Poster

    Science.gov (United States)

    After 34 years at NCI, Robert Wiltrout, Ph.D., said he is looking forward to trading his I-270 commute for another type of commute: exploring the waterways of Maryland, Alaska, and Wyoming to fulfill his love of fishing. Wiltrout officially retired as director of the NCI Center for Cancer Research (CCR) on July 2 of last year. Throughout his college academic career, Wiltrout had an interest in science, but it was not until he was working on a research project for his master’s degree that he considered a career in scientific research.

  14. NCI Visuals Online

    Science.gov (United States)

    NCI Visuals Online contains images from the collections of the National Cancer Institute's Office of Communications and Public Liaison, including general biomedical and science-related images, cancer-specific scientific and patient care-related images, and portraits of directors and staff of the National Cancer Institute.

  15. [Plummer-Vinson syndrome or related syndrome in 3 black African women].

    Science.gov (United States)

    Aubry, P; Oddes, B; Chazouillères, O; Lebourgeois, M; Delanoue, G; Seurat, P L

    1985-01-01

    The Plummer-Vinson syndrome or "sideropenic dysphagia" is exceptional among Blacks. One case was recently reported in a female patient from Guadeloupe. This study pertains to three cases observed in Senegalese Black women aged 28, 27, and 41 years. These three women were admitted for a dysphagia, in fact in evidence 10, 4, and 7 years respectively before the diagnosis was made. A clinical anemia was noted twice in addition to mucocutaneous disorders (cases 1 and 2). The laboratory tests showed in all three cases a hypochromic microcytic sideropenic anemia (serum iron levels at 32, 14, and 31 mcg 100 ml respectively). Barium swallow films showed esophageal rings in front of C5-C6 (case 1) of T2-T3 (case 2) and a web of fine mucosal folds in front of C5-C6 (case 3). These films were confirmed cineradiographically by esophagoscopy. The treatment consisted of blood transfusions (cases 1 and 2) and administration of iron by injections and or per os. The endoscopic exams were repeated two or three times. Medical treatment rapidly changed the course of disease for the better. No cause for bleeding was found. A chemical achlorhydria (case 1), a provoked hypoachlorhydria (cases 2 and 3) can be retained as associated factors. In light of the frequency of esophageal membranes in the general population and the incidence of sideropenic anemias among African women, the Plummer-Vinson syndrome should be more often detected in Black Africa.

  16. Data Sets from Major NCI Initiaves

    Science.gov (United States)

    The NCI Data Catalog includes links to data collections produced by major NCI initiatives and other widely used data sets, including animal models, human tumor cell lines, epidemiology data sets, genomics data sets from TCGA, TARGET, COSMIC, GSK, NCI60.

  17. NCI Pediatric Preclinical Testing Consortium

    Science.gov (United States)

    NCI has awarded grants to five research teams to participate in its Pediatric Preclinical Testing Consortium, which is intended to help to prioritize which agents to pursue in pediatric clinical trials.

  18. NCI's Role in Immunotherapy Research

    Science.gov (United States)

    ... Reporting & Auditing Grant Transfer Grant Closeout Contracts & Small Business Training Cancer Training at NCI (Intramural) Resources for ... promising immunotherapies to the clinic more efficiently and cost effectively. For ... of the checkpoint inhibitor pembrolizumab in patients with ...

  19. NCI collaborates with Multiple Myeloma Research Foundation

    Science.gov (United States)

    The National Cancer Institute (NCI) announced a collaboration with the Multiple Myeloma Research Foundation (MMRF) to incorporate MMRF's wealth of genomic and clinical data on the disease into the NCI Genomic Data Commons (GDC), a publicly available datab

  20. NCI Alliance for Nanotechnology in Cancer

    Science.gov (United States)

    The NCI Alliance for Nanotechnology in Cancer funds the Cancer Nanotechnology Training Centers collectively with the NCI Cancer Training Center. Find out about the funded Centers, to date, that train our next generation of scientists in the field of Canc

  1. License Agreements | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    NCI Technology Transfer Center (TTC) licenses the discoveries of NCI and nine other NIH Institutes so new technologies can be developed and commercialized, to convert them into public health benefits.

  2. NCI Holds on to Defelice Cup | Poster

    Science.gov (United States)

    NCI kept the Defelice Cup trophy this year after beating Leidos Biomedical Research, 15 to 9, at the 10th annual Ronald H. Defelice Golf Tournament held on Columbus Day. Sixteen players on each team battled it out at the yearly contractor vs. government tournament held at Rattlewood Golf Course in Mount Airy, Md. NCI leads the series 6–4. “The score was the highest NCI margin

  3. Selected Publications by the NCI Director

    Science.gov (United States)

    Dr. Norman Sharpless's written work on cancer research appears in many leading scientific journals, as well as a variety of other publications. This page lists some of the articles published by Dr. Sharpless since becoming NCI director.

  4. Find an NCI-Designated Cancer Center

    Science.gov (United States)

    Find the locations of NCI-designated cancer centers by area, region, state, or name that includes contact information to help health care providers and cancer patients with referrals to clinical trials.

  5. About TTC | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The TTC facilitates licensing and co-development partnerships between biomedical industry, academia, and government agencies and the research laboratories of the NCI and nine other institutes and centers of NIH.

  6. Life Outside NCI | Cancer Prevention Fellowship Program

    Science.gov (United States)

    The CPFP Office is located at the NCI facilities in Rockville, Maryland, near the Nation’s Capital. With the convenient Metro subway reaching throughout the metropolitan area, transportation is within easy reach.

  7. NCI at Frederick Ebola Response Team | Poster

    Science.gov (United States)

    Editor’s note: This article was adapted from the Employee Diversity Team’s display case exhibit “Recognizing the NCI at Frederick Ebola Response Team,” in the lobby of Building 549. The Poster staff recognizes that this article does not include everyone who was involved in the response to the Ebola crisis, both at NCI at Frederick and in Africa. When the Ebola crisis broke out

  8. International Fellows of NCI at Frederick | Poster

    Science.gov (United States)

    Each year, the Employee Diversity Team (EDT) acknowledges members of the NCI at Frederick Community for their achievements and contributions towards the mission of facility.  Historically, the team has profiled the “Women of NCI at Frederick,” but this year, the team decided to instead shed light on the diverse and successful individuals who make up the international fellows community.

  9. NCI's Distributed Geospatial Data Server

    Science.gov (United States)

    Larraondo, P. R.; Evans, B. J. K.; Antony, J.

    2016-12-01

    Earth systems, environmental and geophysics datasets are an extremely valuable source of information about the state and evolution of the Earth. However, different disciplines and applications require this data to be post-processed in different ways before it can be used. For researchers experimenting with algorithms across large datasets or combining multiple data sets, the traditional approach to batch data processing and storing all the output for later analysis rapidly becomes unfeasible, and often requires additional work to publish for others to use. Recent developments on distributed computing using interactive access to significant cloud infrastructure opens the door for new ways of processing data on demand, hence alleviating the need for storage space for each individual copy of each product. The Australian National Computational Infrastructure (NCI) has developed a highly distributed geospatial data server which supports interactive processing of large geospatial data products, including satellite Earth Observation data and global model data, using flexible user-defined functions. This system dynamically and efficiently distributes the required computations among cloud nodes and thus provides a scalable analysis capability. In many cases this completely alleviates the need to preprocess and store the data as products. This system presents a standards-compliant interface, allowing ready accessibility for users of the data. Typical data wrangling problems such as handling different file formats and data types, or harmonising the coordinate projections or temporal and spatial resolutions, can now be handled automatically by this service. The geospatial data server exposes functionality for specifying how the data should be aggregated and transformed. The resulting products can be served using several standards such as the Open Geospatial Consortium's (OGC) Web Map Service (WMS) or Web Feature Service (WFS), Open Street Map tiles, or raw binary arrays under

  10. CRADA Payment Options | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    NCI TTC CRADA PAYMENT OPTIONS: Electronic Payments by Wire Transfer via Fedwire, Mail a check to the Institute or Center, or Automated Clearing House (ACH)/Electronic Funds Transfer (ETF) payments via Pay.gov (NCI ONLY).

  11. PhD Dissertations

    OpenAIRE

    Redazione Reti Medievali (a cura di)

    2010-01-01

    Report of PhD Dissertations.Anna Airò La scrittura delle regole. Politica e istituzioni a Taranto nel Quattrocento, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 Pasquale Arfé La Clavis Physicae II (316-529) di Honorius Augustodunensis. Studio ed edizione critica, Tesi di dottorato in Storia della filosofia medievale, Università degli Studi di Napoli "L'Orientale", 2005 Alessandro Azzimonti Scrittura agiografica e strutture di potere nell'Italia c...

  12. NCI International EBV-Gastric Cancer Consortium

    Science.gov (United States)

    A collaboration among NCI and extramural investigators, established by DCEG in 2006, that utilizes data and biospecimens from completed and ongoing case series and observational studies of gastric cancer to replicate and extend findings from previous studies hindered by small numbers of EBV-positive cases, and to stimulate multidisciplinary research in this area.

  13. At NCI, Supporting the Best Science

    Science.gov (United States)

    Yesterday, at the AACR annual meeting, Dr. Doug Lowy spoke directly to the research community about his goals as NCI Acting Director. Dr. Lowy said that he plans to continue many of the programs launched by his predecessor, Dr. Harold Varmus, and to sharp

  14. A PhD is a PhD is a PhD

    OpenAIRE

    Ostrow, Deborah Anne

    2017-01-01

    A PhD is a PhD is a PhD is a practice-based project that interrogates the process of an artist undertaking PhD research under established criteria. It consists of an exegesis, an original screenplay, and a digital film made for online viewing, with images drawn from a range of documentaries and films found on YouTube. They have been dissected, re-assembled and then re-embedded to YouTube. The source material covers topics such as medicalization of madness, the conspicuous appropriation of uni...

  15. UNC Cancer Center Director to Lead NCI.

    Science.gov (United States)

    2017-08-01

    President Donald Trump has selected Norman "Ned" Sharpless, MD, director of the University of North Carolina Lineberger Comprehensive Cancer Center, to lead the NCI. The news was met with widespread approval among cancer researchers, who view Sharpless as a strong communicator who can ably represent the needs of the cancer community in the face of proposed funding cuts. ©2017 American Association for Cancer Research.

  16. Revisiting Plummer Vinson Syndrome

    African Journals Online (AJOL)

    Annals of Medical and Health Sciences Research | Jan-Mar 2013 | Vol 3 | Issue 1 |. 119. Address for ... on cervical webs and either overt or latent iron deficiency suggesting no ... whitish narrowing suggestive of a post cricoid web at the C5 vertebra‑level [Figure 1] ... and she was counseled for frequent follow‑ups. Discussion.

  17. NCI's Transdisciplinary High Performance Scientific Data Platform

    Science.gov (United States)

    Evans, Ben; Antony, Joseph; Bastrakova, Irina; Car, Nicholas; Cox, Simon; Druken, Kelsey; Evans, Bradley; Fraser, Ryan; Ip, Alex; Kemp, Carina; King, Edward; Minchin, Stuart; Larraondo, Pablo; Pugh, Tim; Richards, Clare; Santana, Fabiana; Smillie, Jon; Trenham, Claire; Wang, Jingbo; Wyborn, Lesley

    2016-04-01

    The Australian National Computational Infrastructure (NCI) manages Earth Systems data collections sourced from several domains and organisations onto a single High Performance Data (HPD) Node to further Australia's national priority research and innovation agenda. The NCI HPD Node has rapidly established its value, currently managing over 10 PBytes of datasets from collections that span a wide range of disciplines including climate, weather, environment, geoscience, geophysics, water resources and social sciences. Importantly, in order to facilitate broad user uptake, maximise reuse and enable transdisciplinary access through software and standardised interfaces, the datasets, associated information systems and processes have been incorporated into the design and operation of a unified platform that NCI has called, the National Environmental Research Data Interoperability Platform (NERDIP). The key goal of the NERDIP is to regularise data access so that it is easily discoverable, interoperable for different domains and enabled for high performance methods. It adopts and implements international standards and data conventions, and promotes scientific integrity within a high performance computing and data analysis environment. NCI has established a rich and flexible computing environment to access to this data, through the NCI supercomputer; a private cloud that supports both domain focused virtual laboratories and in-common interactive analysis interfaces; as well as remotely through scalable data services. Data collections of this importance must be managed with careful consideration of both their current use and the needs of the end-communities, as well as its future potential use, such as transitioning to more advanced software and improved methods. It is therefore critical that the data platform is both well-managed and trusted for stable production use (including transparency and reproducibility), agile enough to incorporate new technological advances and

  18. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2004-06-01

    Full Text Available Report of PhD Dissertations. Francesco Barone Istituzioni, società ed economia a Catania nel tardo medioevo (XIV-XV secolo, Tesi di dottorato in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004   Laura Berti Ceroni Il territorio e le strutture di Cesarea e Classe tra tarda antichità e alto medioevo in rapporto con Ravenna, Tesi di dottorato di ricerca in Storia e Informatica, Università degli studi di Bologna, 2002-2003.   Marco Bicchierai Poppi dalla signoria dei conti Guidi al vicariato del Casentino (1360-1480, Tesi di dottorato in Storia medievale (XIV ciclo, Università degli Studi di Firenze, 2004   Emanuela Garimberti Spatiosa ad habitandum loca. Luoghi e identità nella Historia Langobardorum di Paolo Diacono, Tesi di dottorato in Storia medievale (XV ciclo, Università degli Studi di Bologna, 2004   Lorenzo Tanzini Sistemi normativi e pratiche istituzionali a Firenze dalla fine del XIII all’inizio del XV secolo, Tesi di dottorato di ricerca in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004   Stefania Tarquini Pellegrinaggio e asseto urbano di Roma, Tesi di dottorato di ricerca in Storia dei centri, delle vie e della cultura dei pellegrinaggi nel Medioevo euro mediterraneo (XV ciclo, Università degli studi di Lecce, 2003

  19. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2010-06-01

    Full Text Available Report of PhD dissertations. Andrea Brugnoli Una storia locale: l’organizzazione del territorio veronese nel medioevo: trasformazioni della realtà e schemi notarili (IX-metà XII secolo, Tesi di dottorato di ricerca in Scienze Storiche e Antropologiche (XXII ciclo, Università degli Studi di Verona, 2010   Luca Filangieri Famiglie e gruppi dirigenti a Genova (secoli XII-metà XIII, Tesi di dottorato di ricerca in Storia medievale (XXII ciclo, Università degli Studi di Firenze, 2010   Jakub Kujawi ski Wernakularna kolekcja historiograficzna z rękopisu francuskiego nr 688 z Biblioteki Narodowej w Paryżu. Studium źródłoznawcze (La raccolta dei volgarizzamenti delle opere storiografiche nel manoscritto francese 688 della Biblioteca Nazionale di Parigi, Tesi di dottorato, Università “Adam Mickiewicz”, Facoltà di Storia, Pozna, a.a. 2009/2010   Marta Longhi I signori “de Radicata”. Strategie di affermazione familiare e patrimoniale nel Piemonte dei secoli XII-XIV, Tesi di dottorato di ricerca in Istituzioni, Società, Religioni dal Tardo Antico alla fine del Medioevo (XX ciclo, Università di Torino, 2008

  20. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2003-06-01

    Full Text Available Reporto of PhD Dissertations.   Mario Dalle Carbonare Società, potere e clientele nell’Irlanda altomedievale (secoli V-IX, Tesi di dottorato di ricerca in Storia sociale europea, Università "Ca' Foscari" di Venezia, 2003 Vieri Mazzoni La legislazione antighibellina e la politica oligarchica della Parte Guelfa di Firenze nel secondo Trecento (1347-1378, Tesi di dottorato di ricerca in Storia Medievale (ciclo XII, Università degli Studi di Firenze   Alma Poloni Pisa dalle origini del movimento popolare alla discesa di Ludovico il Bavaro. I gruppi dirigenti cittadini tra continuità e trasformazione, Tesi di dottorato di ricerca in Storia dell'Europa nel medioevo, Università degli studi di Pisa, 2003   Andrea Puglia Potere marchionale, amministrazione del territorio, società locali dalla morte di Ugo di Tuscia a Guelfo VI di Baviera (1001-1160, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Milano, 2003

  1. Industrial PhD report: Sustainable Innovation

    DEFF Research Database (Denmark)

    Olesen, Gitte Gylling Hammershøj

    2011-01-01

    Erhvervs PhD rapport udarbejdet i tilknytning til Erhvervs PhD kurset der er obligatorisk for Erhvervs PhD studerende. Rapporten omhandler relationer melllem den akademiske verden og industrien i sammenhæng med PhD projektet, betragtet og analyseret gennem teori om bæredygtig innovation....

  2. A Case of Plummer-Vinson Syndrome Showing Rapid Improvement of Dysphagia and Esophageal Web after Two Weeks of Iron Therapy

    Directory of Open Access Journals (Sweden)

    Tomomitsu Tahara

    2014-06-01

    Full Text Available Plummer-Vinson syndrome (PVS is a rare entity characterized by upper esophageal webs and iron deficiency anemia. We report a case of PVS whose esophageal web was rapidly improved by iron therapy. A 77-year-old woman was admitted to our hospital with complaints of dysphagia, vomiting, shortness of breath and weight loss for 1 month. Physical examination revealed conjunctival pallor, koilonychia, angular cheilitis and smooth tongue, and laboratory findings were consistent with microcytic hypochromic anemia with iron deficiency. Gastrointestinal endoscopy and barium-swallow esophagography detected a web that prevented passage of the endoscope into the upper portion of the esophagus. The patient received oral iron therapy daily; the hemoglobin concentration rose to 8.9 g/dl and the complaints of dysphagia were dramatically improved after 2 weeks, with improvement of luminal stenosis confirmed by gastrointestinal endoscopy and barium-swallow esophagography. The PVS described in this report had a distinct clinical course, showing very rapid improvement of dysphagia and esophageal web after 2 weeks of oral iron therapy.

  3. Mission & Role | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The NCI TTC serves as the focal point for implementing the Federal Technology Transfer Act to utilize patents as incentive for commercial development of technologies and to establish research collaborations and licensing among academia, federal laboratories, non-profit organizations, and industry. The TTC supports technology development activities for the National Cancer Institute and nine other NIH Institutes and Centers. TTC staff negotiate co-development agreements and licenses with universities, non-profit organizations, and pharmaceutical and biotechnology companies to ensure compliance with Federal statutes, regulations and the policies of the National Institutes of Health. TTC also reviews employee invention reports and makes recommendations concerning filing of domestic and foreign patent applications. | [google6f4cd5334ac394ab.html

  4. Paulette Gray, Ph.D.

    Science.gov (United States)

    Paulette S. Gray, Ph.D. is the Director for the Division of Extramural Activities (DEA). As the director of the division, she is responsible for the overall scientific, fiscal, and administrative management of the division, including broad strategic planning, development, implementation, and evaluation.

  5. PhD students and integrative research

    NARCIS (Netherlands)

    Fry, G.; Tress, B.; Tress, G.

    2006-01-01

    The training of PhD students is currently very dynamic and varies widely from place to place. We present some examples of this variation and comment on how it may affect the way PhD students cope with integrative studies. Our focus is on the training needs of PhD students studying integrative

  6. Published Research - NCI Alliance for Nanotechnology in Cancer

    Science.gov (United States)

    The NCI Alliance for Nanotechnology in Cancer has published much exciting and impactful research over the years. Find here a list of all of these listed in PubMed and others across the field of Cancer Nanotechnology.

  7. NCI and the Precision Medicine Initiative®

    Science.gov (United States)

    NCI's activities related to precision medicine focuses on new and expanded precision medicine clinical trials; mechanisms to overcome drug resistance to cancer treatments; and developing a shared digital repository of precision medicine trials data.

  8. NCI-MATCH Trial Links Targeted Drugs to Mutations

    Science.gov (United States)

    Investigators for the nationwide trial, NCI-MATCH: Molecular Analysis for Therapy Choice, announced that the trial will seek to determine whether targeted therapies for people whose tumors have specific gene mutations will be effective regardless of their cancer type. NCI-MATCH will incorporate more than 20 different study drugs or drug combinations, each targeting a specific gene mutation, in order to match each patient in the trial with a therapy that targets a molecular abnormality in their tumor.

  9. Invention Development Program Helps Nurture NCI at Frederick Technologies | Poster

    Science.gov (United States)

    The Invention Development Fund (IDF) was piloted by the Technology Transfer Center (TTC) in 2014 to facilitate the commercial development of NCI technologies. The IDF received a second round of funding from the NCI Office of the Director and the Office of Budget and Management to establish the Invention Development Program (IDP) for fiscal year 2016. The IDP is using these funds to help advance a second set of inventions.

  10. Purification and crystallization of Phd, the antitoxin of the phd/doc operon

    International Nuclear Information System (INIS)

    Garcia-Pino, Abel; Sterckx, Yann; Vandenbussche, Guy; Loris, Remy

    2010-01-01

    The antitoxin Phd from the phd/doc operon of bacteriophage P1 was crystallized in two distinct crystal forms. The antitoxin Phd from the phd/doc module of bacteriophage P1 was crystallized in two distinct crystal forms. Crystals of His-tagged Phd contain a C-terminally truncated version of the protein and diffract to 2.20 Å resolution. Crystals of untagged Phd purified from the Phd–Doc complex diffract to 2.25 Å resolution. These crystals are partially merohedrally twinned and contain the full-length version of the protein

  11. DNA fingerprinting of the NCI-60 cell line panel.

    Science.gov (United States)

    Lorenzi, Philip L; Reinhold, William C; Varma, Sudhir; Hutchinson, Amy A; Pommier, Yves; Chanock, Stephen J; Weinstein, John N

    2009-04-01

    The National Cancer Institute's NCI-60 cell line panel, the most extensively characterized set of cells in existence and a public resource, is frequently used as a screening tool for drug discovery. Because many laboratories around the world rely on data from the NCI-60 cells, confirmation of their genetic identities represents an essential step in validating results from them. Given the consequences of cell line contamination or misidentification, quality control measures should routinely include DNA fingerprinting. We have, therefore, used standard DNA microsatellite short tandem repeats to profile the NCI-60, and the resulting DNA fingerprints are provided here as a reference. Consistent with previous reports, the fingerprints suggest that several NCI-60 lines have common origins: the melanoma lines MDA-MB-435, MDA-N, and M14; the central nervous system lines U251 and SNB-19; the ovarian lines OVCAR-8 and OVCAR-8/ADR (also called NCI/ADR); and the prostate lines DU-145, DU-145 (ATCC), and RC0.1. Those lines also show that the ability to connect two fingerprints to the same origin is not affected by stable transfection or by the development of multidrug resistance. As expected, DNA fingerprints were not able to distinguish different tissues-of-origin. The fingerprints serve principally as a barcodes.

  12. An NCI perspective on creating sustainable biospecimen resources.

    Science.gov (United States)

    Vaught, Jimmie; Rogers, Joyce; Myers, Kimberly; Lim, Mark David; Lockhart, Nicole; Moore, Helen; Sawyer, Sherilyn; Furman, Jeffrey L; Compton, Carolyn

    2011-01-01

    High-quality biospecimens with appropriate clinical annotation are critical in the era of personalized medicine. It is now widely recognized that biospecimen resources need to be developed and operated under established scientific, technical, business, and ethical/legal standards. To date, such standards have not been widely practiced, resulting in variable biospecimen quality that may compromise research efforts. The National Cancer Institute (NCI) Office of Biorepositories and Biospecimen Research (OBBR) was established in 2005 to coordinate NCI's biospecimen resource activities and address those issues that affect access to the high-quality specimens and data necessary for its research enterprises as well as the broader translational research field. OBBR and the NCI Biorepository Coordinating Committee developed NCI's "Best Practices for Biospecimen Resources" after consultation with a broad array of experts. A Biospecimen Research Network was established to fund research to develop additional evidence-based practices. Although these initiatives will improve the overall availability of high-quality specimens and data for cancer research, OBBR has been authorized to implement a national biobanking effort, cancer HUman Biobank (caHUB). caHUB will address systematically the gaps in knowledge needed to improve the state-of-the-science and strengthen the standards for human biobanking. This commentary outlines the progressive efforts by NCI in technical, governance, and economic considerations that will be important as the new caHUB enterprise is undertaken.

  13. The NCI Digital Divide Pilot Projects: implications for cancer education.

    Science.gov (United States)

    Kreps, Gary L; Gustafson, David; Salovey, Peter; Perocchia, Rosemarie Slevin; Wilbright, Wayne; Bright, Mary Anne; Muha, Cathy

    2007-01-01

    The National Cancer Institute (NCI) supported four innovative demonstration research projects, "The Digital Divide Pilot Projects," to test new strategies for disseminating health information via computer to vulnerable consumers. These projects involved active research collaborations between the NCI's Cancer Information Service (CIS) and regional cancer control researchers to field test new approaches for enhancing cancer communication in vulnerable communities. The projects were able to use computers to successfully disseminate relevant cancer information to vulnerable populations. These demonstration research projects suggested effective new strategies for using communication technologies to educate underserved populations about cancer prevention, control, and care.

  14. Urbanism PhD Research 2008 - 2010

    NARCIS (Netherlands)

    Smit, M.; Van der Hoeven, F.D.; Brand, N.; Van der Burg, L.; Çal??kan, O.; Tan, E.R.; Wang, C.Y.; Zhou, J.

    2009-01-01

    To ensure the quality of the Ph.D. research the Department introduced a special procedure for periodic evaluation: after a period of nine months the potential Ph.D. candidates are asked to present their research design, theoretical framework and methodological approach to the members of the

  15. New Phone System Coming to NCI Campus at Frederick | Poster

    Science.gov (United States)

    By Travis Fouche and Trent McKee, Guest Writers Beginning in September, phones at the NCI Campus at Frederick will begin to be replaced, as the project to upgrade the current phone system ramps up. Over the next 16 months, the Information Systems Program (ISP) will be working with Facilities Maintenance and Engineering and Computer & Statistical Services to replace the current

  16. NIH Employee Invention Report (EIR) | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    NIH researchers must immediately contact their Laboratory or Branch Chief and inform him or her of a possible invention, and then consult with your NCI TTC Technology Transfer Manager about submitting an Employee Invention Report (EIR) Form. | [google6f4cd5334ac394ab.html

  17. Russian delegation visits NIH and NCI to discuss research collaboration

    Science.gov (United States)

    The NCI Center for Global Health hosted a delegation from the Russian Foundation for Basic Research to discuss ongoing and future collaborations in cancer research. The delegation was accompanied by representatives from the US Embassy in Moscow and the Embassy of the Russian Federation in Washington DC.

  18. Creating Start-up Companies around NCI Inventions | Poster

    Science.gov (United States)

    By Karen Surabian, Thomas Stackhouse, and Rose Freel, Contributing Writers, and Rosemarie Truman, Guest Writer The National Cancer Institute (NCI), led by the Technology Transfer Center (TTC),  the Avon Foundation, and The Center for Advancing Innovation have partnered to create a “first-of-a-kind” Breast Cancer Start-up Challenge.

  19. Help NCI at Frederick “Knock Out Hunger” | Poster

    Science.gov (United States)

    NCI at Frederick is once again participating in the Feds Feed Families initiative, an annual food drive that addresses severe shortages of non-perishable items in food banks across D.C., Maryland, and Virginia during the summer months, when giving is at its lowest.

  20. IJUE. Tema 3. Les competències de la Unió Europea

    OpenAIRE

    Torres Pérez, María

    2018-01-01

    PowerPoint del Tema 3 de la asignatura "Institucions Jurídiques de la Unió Europea". Curso académico 2017-2018. Tema 3. Les competències de la Unió Europea. 1. L’atribució de competències a la Unió Europea. 2. La delimitació de les competències a la Unió Europea. 3. Els principis que regeixen l’exercici de les competències. 4. L’exercici de les competències de la Unió per “alguns Estats membres”.

  1. 76 FR 28439 - Submission for OMB Review; Comment Request; NCI Cancer Genetics Services Directory Web-Based...

    Science.gov (United States)

    2011-05-17

    ...; Comment Request; NCI Cancer Genetics Services Directory Web-Based Application Form and Update Mailer... currently valid OMB control number. Proposed Collection: Title: NCI Cancer Genetics Services Directory Web... included in the NCI Cancer Genetics Services Directory on NCI's Cancer.gov Web site. The information...

  2. Regular paths in SparQL: querying the NCI Thesaurus.

    Science.gov (United States)

    Detwiler, Landon T; Suciu, Dan; Brinkley, James F

    2008-11-06

    OWL, the Web Ontology Language, provides syntax and semantics for representing knowledge for the semantic web. Many of the constructs of OWL have a basis in the field of description logics. While the formal underpinnings of description logics have lead to a highly computable language, it has come at a cognitive cost. OWL ontologies are often unintuitive to readers lacking a strong logic background. In this work we describe GLEEN, a regular path expression library, which extends the RDF query language SparQL to support complex path expressions over OWL and other RDF-based ontologies. We illustrate the utility of GLEEN by showing how it can be used in a query-based approach to defining simpler, more intuitive views of OWL ontologies. In particular we show how relatively simple GLEEN-enhanced SparQL queries can create views of the OWL version of the NCI Thesaurus that match the views generated by the web-based NCI browser.

  3. Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer

    International Nuclear Information System (INIS)

    Rawluszko, Agnieszka A; Bujnicka, Katarzyna E; Horbacka, Karolina; Krokowicz, Piotr; Jagodziński, Paweł P

    2013-01-01

    Colorectal cancer (CRC) is one of the most common and comprehensively studied malignancies. Hypoxic conditions during formation of CRC may support the development of more aggressive cancers. Hypoxia inducible factor (HIF), a major player in cancerous tissue adaptation to hypoxia, is negatively regulated by the family of prolyl hydroxylase enzymes (PHD1, PHD2, PHD3) and asparaginyl hydroxylase, called factor inhibiting HIF (FIH). PHD1, PHD2, PHD3 and FIH gene expression was evaluated using quantitative RT-PCR and western blotting in primary colonic adenocarcinoma and adjacent histopathologically unchanged colonic mucosa from patients who underwent radical surgical resection of the colon (n = 90), and the same methods were used for assessment of PHD3 gene expression in HCT116 and DLD-1 CRC cell lines. DNA methylation levels of the CpG island in the promoter regulatory region of PHD1, PHD2, PHD3 and FIH were assessed using bisulfite DNA sequencing and high resolution melting analysis (HRM) for patients and HRM analysis for CRC cell lines. We found significantly lower levels of PHD1, PHD2 and PHD3 transcripts (p = 0.00026; p < 0.00001; p < 0.00001) and proteins (p = 0.004164; p = 0.0071; p < 0.00001) in primary cancerous than in histopathologically unchanged tissues. Despite this, we did not observe statistically significant differences in FIH transcript levels between cancerous and histopathologically unchanged colorectal tissue, but we found a significantly increased level of FIH protein in CRC (p = 0.0169). The reduced PHD3 expression was correlated with significantly increased DNA methylation in the CpG island of the PHD3 promoter regulatory region (p < 0.0001). We did not observe DNA methylation in the CpG island of the PHD1, PHD2 or FIH promoter in cancerous and histopathologically unchanged colorectal tissue. We also showed that 5-Aza-2’-deoxycytidine induced DNA demethylation leading to increased PHD3 transcript and protein level in HCT116 cells. We

  4. Like a Good Neighbor, NCI-Frederick Is There | Poster

    Science.gov (United States)

    The main campus of the National Cancer Institute at Frederick is an island of sorts: 68 acres of land that was once part of Fort Detrick. Accessing NCI property means passing through the Fort Detrick gates and crossing the post. While the campus is surrounded by the military installation, is protected by NIH police, and doesn’t allow the use of tobacco products, it is not a

  5. Softball Games Bring NCI and Leidos Biomed Employees Together | Poster

    Science.gov (United States)

    NCI and Leidos Biomed employees took to the fields at Nallin Pond for the third annual slow-pitch softball games on August 26. The series attracted 54 employees who were divided into four teams, Red, Blue, Gray, and White, and they were cheered on by about 40 enthusiastic spectators. In the first set of games, the Gray team defeated the Blue team, 15–8, and the White team

  6. NCI investment in nanotechnology: achievements and challenges for the future.

    Science.gov (United States)

    Dickherber, Anthony; Morris, Stephanie A; Grodzinski, Piotr

    2015-01-01

    Nanotechnology offers an exceptional and unique opportunity for developing a new generation of tools addressing persistent challenges to progress in cancer research and clinical care. The National Cancer Institute (NCI) recognizes this potential, which is why it invests roughly $150 M per year in nanobiotechnology training, research and development. By exploiting the various capacities of nanomaterials, the range of nanoscale vectors and probes potentially available suggests much is possible for precisely investigating, manipulating, and targeting the mechanisms of cancer across the full spectrum of research and clinical care. NCI has played a key role among federal R&D agencies in recognizing early the value of nanobiotechnology in medicine and committing to its development as well as providing training support for new investigators in the field. These investments have allowed many in the research community to pursue breakthrough capabilities that have already yielded broad benefits. Presented here is an overview of how NCI has made these investments with some consideration of how it will continue to work with this research community to pursue paradigm-changing innovations that offer relief from the burdens of cancer. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.

  7. Global Proteome Analysis of the NCI-60 Cell Line Panel

    Directory of Open Access Journals (Sweden)

    Amin Moghaddas Gholami

    2013-08-01

    Full Text Available The NCI-60 cell line collection is a very widely used panel for the study of cellular mechanisms of cancer in general and in vitro drug action in particular. It is a model system for the tissue types and genetic diversity of human cancers and has been extensively molecularly characterized. Here, we present a quantitative proteome and kinome profile of the NCI-60 panel covering, in total, 10,350 proteins (including 375 protein kinases and including a core cancer proteome of 5,578 proteins that were consistently quantified across all tissue types. Bioinformatic analysis revealed strong cell line clusters according to tissue type and disclosed hundreds of differentially regulated proteins representing potential biomarkers for numerous tumor properties. Integration with public transcriptome data showed considerable similarity between mRNA and protein expression. Modeling of proteome and drug-response profiles for 108 FDA-approved drugs identified known and potential protein markers for drug sensitivity and resistance. To enable community access to this unique resource, we incorporated it into a public database for comparative and integrative analysis (http://wzw.tum.de/proteomics/nci60.

  8. PhD supervisor-student relationship

    Directory of Open Access Journals (Sweden)

    FILIPE PRAZERES

    2017-10-01

    Full Text Available The relationship between the PhD supervisor and the PhD student is a complex one. When this relationship is neither effective nor efficient, it may yield negative consequences, such as academic failure (1. The intricacy of the supervisor-student relationship may be in part comparable to the one between the physician and his/her patient [see, for example (2]. Both interactions develop over several years and the players involved in each relationship – PhD supervisor-student on the one side and physician-patient on the other side – may at some point of the journey develop different expectations of one another [see, for example (3, 4] and experience emotional distress (5. In both relationships, the perceived satisfaction with the interaction will contribute to the success or failure of the treatment in one case, and in the other, the writing of a thesis. To improve the mentioned satisfaction, not only there is a need to invest time (6, as does the physician to his/ her patients, but also both the supervisor and the PhD student must be willing to negotiate a research path to follow that would be practical and achievable. The communication between the physician and patient is of paramount importance for the provision of health care (7, and so is the communication between the supervisor and PhD student which encourages the progression of both the research and the doctoral study (8. As to a smooth transition to the postgraduate life, supervisors should start thinking about providing the same kind of positive reinforcement that every student is used to experience in the undergraduate course. The recognition for a job well done will mean a lot for a PhD student, as it does for a patient. One good example is the increase in medication compliance by patients with high blood pressure who receive positive reinforcement from their physicians (9. Supervisors can organize regular meetings for (and with PhD students in order to not only discuss their projects

  9. NCI Takes Back the Defelice Cup at Ninth Annual Golf Tournament | Poster

    Science.gov (United States)

    By Ashley DeVine, Staff Writer After being down by a point in the morning, NCI reclaimed the Defelice Cup trophy from Leidos Biomedical Research, with a final score of 12 ½ to 11 ½, at the ninth annual Ronald H. Defelice Golf Tournament, held Oct. 13. “The tightest matches in the nine-year history of this cup competition resulted in a narrow victory for NCI and allowed NCI to

  10. ATLAS PhD Grants 2015

    CERN Multimedia

    Marcelloni De Oliveira, Claudia

    2015-01-01

    ATLAS PHd Grants - We are excited to announce the creation of a dedicated grant scheme (thanks to a donation from Fabiola Gianotti and Peter Jenni following their award from the Fundamental Physics Prize foundation) to encourage young and high-caliber doctoral students in particle physics research (including computing for physics) and permit them to obtain world class exposure, supervision and training within the ATLAS collaboration. This special PhD Grant is aimed at graduate students preparing a doctoral thesis in particle physics (incl. computing for physics) to spend one year at CERN followed by one year support also at the home Institute.

  11. NCI designated cancer center funding not influenced by organizational structure.

    Science.gov (United States)

    Wolfe, Margaret E; Yagoda, Daniel; Thurman, Paul W; Luna, Jorge M; Figg, William Douglas

    2009-05-01

    National Cancer Institutes (NCI) designated cancer centers use one of three organizational structures. The hypothesis of this study is that there are differences in the amount of annual NCI funding per faculty member based on a cancer center's organizational structure. The study also considers the impact of secondary factors (i.e., the existence of a clinical program, the region and the size of the city in which the cancer center is located) on funding and the number of Howard Hughes Medical Institute (HHMI) investigators at each cancer center. Of the 63 cancer centers, 44 use a matrix structure, 16 have a freestanding structure, and three have a Department of Oncology structure. Kruskal-Wallis tests reveal no statistically significant differences in the amount of funding per faculty member or the number of HHMI investigators between centers with a matrix, freestanding or Department of Oncology structure. Online research and telephone interviews with each cancer center were used to gather information, including: organizational structure, the presence of a clinical program, the number of faculty members, and the number of Howard Hughes Medical Institute investigators. Statistical tests were used to assess the impact which organizational structure has on the amount of funding per faculty member and number of HHMI investigators. While the results seem to suggest that the organizational structure of a given cancer center does not impact the amount of NCI funding or number of HHMI investigators which it attracts, the existence of this relationship is likely masked by the small sample size in this study. Further studies may be appropriate to examine the effect organizational structure has on other measurements which are relevant to cancer centers, such as quality and quantity of research produced.

  12. Ressonàncies en plasmons sobre grafè

    OpenAIRE

    Alcaraz Iranzo, David

    2014-01-01

    Treball final de màster oficial fet en col·laboració amb Universitat Autònoma de Barcelona (UAB), Universitat de Barcelona (UB) i Institut de Ciències Fotòniques (ICFO) [ANGLÈS] Graphene is used as a novel, versatile plasmonic material. The most common way to implement resonant light-plasmon coupling is to etch graphene into periodic nanostructures, which is invasive. Here, we study a non-invasive way to engineer graphene plasmon resonances, based on periodic doping profiles. The plasmon r...

  13. Vaccines for HIV | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The development of an effective HIV vaccine has been an ongoing area of research. The high variability in HIV-1 virus strains has represented a major challenge in successful development. Ideally, an effective candidate vaccine would provide protection against the majority of clades of HIV. Two major hurdles to overcome are immunodominance and sequence diversity. This vaccine utilizes a strategy for overcoming these two issues by identifying the conserved regions of the virus and exploiting them for use in a targeted therapy. NCI seeks licensees and/or research collaborators to commercialize this technology, which has been validated in macaque models.

  14. PhD on Track – designing learning for PhD students

    Directory of Open Access Journals (Sweden)

    Gunhild Austrheim

    2013-12-01

    Full Text Available Three years ago we started the project "Information Management for Knowledge Creation". The project was initiated to create online information literacy modules for PhD students. The result of our endeavours, PhD on Track, will be launched in May 2013. The initial stage of the project was mapping out the information behaviour of PhD students, as well as what services they require from the library through a literature review and a focus group study. The findings of these inquiries formed the knowledge base from which we developed our information literacy modules. Our paper will focus on the interaction between content production and user testing when creating PhD on Track. Methods: User testing has been employed throughout the production stage. We have tested navigation and organisation of the web site, content and usability. The project team have conducted expert testing. Analysis: The results from our user testing have played an important part in decisions concerning content production. Our working hypothesis was that the PhD students would want an encyclopaedic website, a place to quickly find answers. However, the user tests revealed that PhD students understood and expected the website to be learning modules. Conclusions: The PhD students in the tests agreed that a site such as this would be useful, especially to new PhD students. They also liked the design, but had some qualms with the level of information. They preferred shorter text, but with more depth. The students would likewise have preferred more practical examples, more illustrations and more discipline specific information. The current content of PhD on Track reflects the feedback from the user testing. We have retained initial ideas such as one section for reviewing and discovering research literature and one section for publishing PhD research work. In addition, we have included more practical examples to indicate efficient workflows or relevant actions in context. Illustrations

  15. The panacea toolbox of a PhD biomedical student.

    Science.gov (United States)

    Skaik, Younis

    2014-01-01

    Doing a PhD (doctor of philosophy) for the sake of contribution to knowledge should give the student an immense enthusiasm through the PhD period. It is the time in one's life that one spends to "hit the nail on the head" in a specific area and topic of interest. A PhD consists mostly of hard work and tenacity; however, luck and genius might also play a little role. You can pass all PhD phases without having both luck and genius. The PhD student should have pre-PhD and PhD toolboxes, which are "sine quibus non" for getting successfully a PhD degree. In this manuscript, the toolboxes of the PhD student are discussed.

  16. Biomedical PhD education - an international perspective

    DEFF Research Database (Denmark)

    Mulvany, Michael J.

    2013-01-01

    The PhD, otherwise known as the doctor of philosophy or Dr. Phil., is an internationally recognized degree, indicating that the PhD graduate has received training in research under supervision. Traditionally, the PhD was the route to an academic career, with most successful PhD graduates receiving...... tenured university positions. However, over the past 20–30 years, and particularly the past 10 years, the situation has changed dramatically. Governments in many countries have invested massively in PhD education, believing that trained researchers will contribute to the ‘knowledge society’, and thus...... increase the competitiveness of their countries in the future economies of the world. Thus, only a small fraction of PhD graduates now end up in academic research. Yet, the PhD remains a research degree, and indeed, institutions have become heavily dependent on PhD students for their research output...

  17. College Graduate with NCI Internship Gains Experience, Carries Chemistry into Medicine | Poster

    Science.gov (United States)

    For Jennifer Marshall, the skills learned through an internship at the National Cancer Institute (NCI) at Frederick have prepared her for the next step of her life—medical school. Marshall, who will be attending the West Virginia University School of Medicine in the fall, spent three summers in NCI at Frederick’s Summer Internship Program expanding her love and passion for

  18. Human Monoclonal Antibodies Targeting Glypican-2 in Neuroblastoma | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    Researchers at the National Cancer Institute’s Laboratory of Molecular Biology (NCI LMB) have developed and isolated several single domain monoclonal human antibodies against GPC2. NCI seeks parties interested in licensing or co-developing GPC2 antibodies and/or conjugates.

  19. NCI Core Open House Shines Spotlight on Supportive Science and Basic Research | Poster

    Science.gov (United States)

    The lobby of Building 549 at NCI at Frederick bustled with activity for two hours on Tuesday, May 1, as several dozen scientists and staff gathered for the NCI Core Open House. The event aimed to encourage discussion and educate visitors about the capabilities of the cores, laboratories, and facilities that offer support to NCI’s Center for Cancer Research.

  20. Vaccine for BK Polyomavirus-associated Infections in Transplant Recipients | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    NCI researches identified a BK polyomavirus (BKV) virulent strain that causes chronic urinary tract infections, and the development of vaccine and therapeutic methods that would block BKV pathogenesis. The NCI Laboratory of Cellular Oncology, seek parties to license or co-develop this technology.

  1. PhD competences of food studies

    Directory of Open Access Journals (Sweden)

    Chelo Gonzalez-Martinez

    2014-10-01

    Full Text Available In European Higher Education, learning outcomes and competences have been used sometimes with different meanings and sometimes with the same meaning. But both terms have been more commonly used to refer to knowledge, understanding and abilities a student must demonstrate at the end of a learning experience.  Their use is a consequence of the paradigm shift of the Bologna Process to a learner centered education environment. The definition of standards of competences (or learning outcomes for the PhD degree is thus a need for the quality assurance of this degree. In this work, subject-specific and generic competences for the PhD in Food Science and Technology and their alignment with the European Qualifications Framework (EQF level descriptors for quality assurance purposes have been identified.

  2. ATLAS PhD Grant Scholarship Programme

    CERN Multimedia

    Abha Eli Phoboo

    2014-01-01

    On 11 February, the first recipients of the ATLAS PhD Grant were presented with a certificate by the programme’s selection committee. The three scholars - Lailin Xu of China, Josefina Alconada of Argentina and Gagik Vardanyan of Armenia - were delighted at being able to continue their PhD programmes at CERN.   With certificates, from left: Lailin Xu, Josefina Alconada, and Gagik Vardanyan. The selection committee members, from left: IFAE Barcelona’s Martine Bosman, Fabiola Gianotti, Peter Jenni and from CERN HR James Purvis. (Image: ATLAS/Claudia Marcelloni). Former ATLAS spokespersons Peter Jenni and Fabiola Gianotti started the fund with the Fundamental Physics Prize award money they received last year. Both have used the entirety of their prizes for educational and humanitarian programmes. "We wanted to do something for students who are working on ATLAS, in particular those who otherwise could not come here and actually see the detector they are working on,&am...

  3. PhD students share their work

    CERN Multimedia

    Joannah Caborn Wengler

    2012-01-01

    Last week, the second Doctoral Student Assembly gave students in the final stages of their PhD at CERN the chance to meet and present their work.   On 9 May, 24 students who are completing their PhD under the CERN Doctoral Student Programme were joined by their CERN supervisors and some of their university supervisors at an event organised by HR and the Technical Students Committee (TSC). After an address by the Director-General Rolf Heuer and short presentations by Ingrid Haug from HR and TSC Chair Stephan Russenschuck, the students presented their work in a poster session. Held in a packed Council Chamber, the event was a great opportunity for the doctoral students to get to know each other and to share their work in fields as diverse as radiation protection, computing, physics and engineering.

  4. Persistent Identifier Practice for Big Data Management at NCI

    Directory of Open Access Journals (Sweden)

    Jingbo Wang

    2017-04-01

    Full Text Available The National Computational Infrastructure (NCI manages over 10 PB research data, which is co-located with the high performance computer (Raijin and an HPC class 3000 core OpenStack cloud system (Tenjin. In support of this integrated High Performance Computing/High Performance Data (HPC/HPD infrastructure, NCI’s data management practices includes building catalogues, DOI minting, data curation, data publishing, and data delivery through a variety of data services. The metadata catalogues, DOIs, THREDDS, and Vocabularies, all use different Uniform Resource Locator (URL styles. A Persistent IDentifier (PID service provides an important utility to manage URLs in a consistent, controlled and monitored manner to support the robustness of our national ‘Big Data’ infrastructure. In this paper we demonstrate NCI’s approach of utilising the NCI’s 'PID Service 'to consistently manage its persistent identifiers with various applications.

  5. The PhD by Publication

    Directory of Open Access Journals (Sweden)

    Susi Peacock

    2017-07-01

    Full Text Available Aim/Purpose: The purpose of this work is to develop more nuanced understandings of the PhD by publication, particularly raising awareness of the retrospective PhD by publication. The article aims to contribute to contemporary debates about the differing pathways to the attainment of doctoral study completion and the artifacts submitted for that purpose. It also seeks to support prospective graduate students and supervisors who are embarking upon alternative routes to doctoral accreditation. Background: The PhD is considered the pinnacle of academic study – highly cherished, and replete with deeply held beliefs. In response to changes in job markets, developments in the disciplines, and more varied student cohorts, diverse pathways to completion of this award have emerged, such as the PhD by publication (PhDP. A PhDP may either be prospective or retrospective. For the former, publications are planned and created with their contributions to the PhDP in mind. The retrospective PhD is assembled after some, or most, of the publications have been completed. The artifact submitted for examination in this case consists of a series of peer-reviewed academic papers, books, chapters, or equivalents that have been published or accepted for publication, accompanied by an over-arching narrative. The retrospective route is particularly attractive for professionals who are research-active but lack formal academic accreditation at the highest level. Methodology: This article calls upon a literature review pertaining to the award of PhDP combined with the work of authors who offer their personal experiences of the award. The author also refers to her candidature as a Scottish doctoral student whilst studying for the award of PhD by publication. Contribution: This work raises awareness of the PhDP as a credible and comparable pathway for graduate students. The article focuses upon the retrospective PhDP which, as with all routes to doctoral accreditation, has

  6. Silica-Coated Nanodiamonds for Imaging and Delivery of Therapeutic Agents | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The NCI Radiation Oncology Branch and the NHLBI Laboratory of Single Molecule Biophysics seek parties to co-develop fluorescent nanodiamonds for use as in vivo and in vitro optical tracking probes toward commercialization.

  7. NCI and the Chinese Academy of Medical Sciences Sign Statement of Intent

    Science.gov (United States)

    Today the National Cancer Institute (NCI) and the Cancer Institute/Hospital of the Chinese Academy of Medical Sciences (CICAMS) signed a statement of intent to share an interest in fostering collaborative biomedical research in oncology and a common goal

  8. History of the Diet History Questionnaire (DHQ) | EGRP/DCCPS/NCI/NIH

    Science.gov (United States)

    Learn about the evolution of the Diet History Questionnaire (DHQ), developed by the National Cancer Institute (NCI) initially in 2001, to the DHQ II in 2010, up to the present version, DHQ III, launched in 2018.

  9. Program Spotlight: Ground Broken for NCI-supported Cancer Treatment Center in Puerto Rico

    Science.gov (United States)

    Dr. Sanya A. Springfield represented NCI at the groundbreaking ceremonies for the University of Puerto Rico (UPR) cancer hospital. In her remarks, she acknowledged the driving force behind this development is the UPR and the MD Anderson Cancer Center partnership.

  10. NCI Requests Cancer Targets for Monoclonal Antibody Production and Characterization | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    In an effort to provide well-characterized monoclonal antibodies to the scientific community, NCI's Antibody Characterization Program requests cancer-related protein targets for affinity production and distribution. Submissions will be accepted through July 11, 2014.

  11. NCI Requests Targets for Monoclonal Antibody Production and Characterization | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    In an effort to provide well-characterized monoclonal antibodies to the scientific community, NCI's Antibody Characterization Program requests cancer-related protein targets for affinity production and distribution. Submissions will be accepted through July 9, 2012.

  12. Gardasil® and Cervarix® | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    Vaccine for human papilloma virus (HPV) to protect from cancers Key elements of the technology for Gardasil® and Cervarix originated from the HPV research of the laboratory of Drs. Douglas Lowy and John Schiller of the NCI.

  13. Ratio Based Biomarkers for the Prediction of Cancer Survival | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The NCI seeks licensees or co-development partners for this technology, which describes compositions, methods and kits for identifying, characterizing biomolecules expressed in a sample that are associated with the presence, the development, or progression of cancer.

  14. How You Can Partner with NIH | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    NCI Technology Transfer Center (TTC) provides an array of agreements to support the National Cancer Institute's partnering. Deciding which type of agreement to use can be a challenge: CRADA, MTA, collaboration, agreement, CTA, Materials-CRADA

  15. Proceedings of the First PhD Symposium on Sustainable Ultrascale Computing Systems (NESUS PhD 2016)

    OpenAIRE

    Carretero Pérez, Jesús; García Blas, Javier; Petcu, Dana

    2016-01-01

    Proceedings of the First PhD Symposium on Sustainable Ultrascale Computing Systems (NESUS PhD 2016) Timisoara, Romania. February 8-11, 2016. The PhD Symposium was a very good opportunity for the young researchers to share information and knowledge, to present their current research, and to discuss topics with other students in order to look for synergies and common research topics. The idea was very successful and the assessment made by the PhD Student was very good. It also helped t...

  16. Young PHD's in Human Space Flight

    Science.gov (United States)

    Wilson, Eleanor

    2002-01-01

    The Cooperating Hampton Roads Organizations for Minorities in Engineering (CHROME) in cooperation with the NASA Office of Space Flight, Human Exploration and Development of Space Enterprise sponsored a summer institute, Young PHD#s (Persons Having Dreams) in Human Space Flight. This 3-day institute used the curriculum of a workshop designed for space professionals, 'Human Space Flight-Analysis and Design: An Integrated, Systematic Approach.' The content was tailored to a high school audience. This institute seeks to stimulate the interest of pre-college students in space flight and motivate them to pursue further experiences in this field. Additionally, this institute will serve as a pilot model for a pre- collegiate training program that can be replicated throughout the country. The institute was complemented with a trip to the Goddard Space Flight Center.

  17. [Stop the compulsive PhD trajectory for junior doctors].

    Science.gov (United States)

    Clevers, J C Hans

    2014-01-01

    It has become the rule rather than the exception that junior doctors in training spend 3-4 years on a research project, culminating in a thesis. Without a PhD, clinical career prospects within and outside academia look rather bleak. Here I argue that PhD degrees should be pursued only by the most talented and motivated young clinicians.

  18. Tracking the PhD Students' Daily Computer Use

    Science.gov (United States)

    Sim, Kwong Nui; van der Meer, Jacques

    2015-01-01

    This study investigated PhD students' computer activities in their daily research practice. Software that tracks computer usage (Manic Time) was installed on the computers of nine PhD students, who were at their early, mid and final stage in doing their doctoral research in four different discipline areas (Commerce, Humanities, Health Sciences and…

  19. Exploring the intricacies of contemporary Phd research process ...

    African Journals Online (AJOL)

    The process leading to a PhD degree award has evolved over a period of many years to become what it is today. There are important considerations and emphasis continually being placed by the degree awarding authorities on the PhD research process leading to this award. The authors of this communication wish to ...

  20. Launching a Geoscience Career: Insights Gained from MS PHD'S Beyond the PhD

    Science.gov (United States)

    Guzman, W. I.; Johnson, A.; Williamson Whitney, V.; Jansma, P. E.; Huggans, M. J.; Ricciardi, L.

    2013-05-01

    The Beyond the PhD (B-PhD) Professional Development Program is the newest addition to the Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S®) Professional Development Program in Earth System Science. This exciting new program is designed to facilitate the development of a new community of underrepresented minority (URM) doctoral candidates and recent doctorate degree recipients in Earth system science (ESS)-related fields. Building upon MS PHD'S extensive professional development activities provided to URM undergraduate and graduate students, B-PhD's vision is to encourage and support URM doctoral students and early career PhD's in becoming part of the global workforce. (Since its inception in 2003, MSPHD'S supports 213 participants of which 42 have achieved the doctoral degree and another 71 are enrolled in doctoral programs.) By providing customized support and advocacy for participants, B-PhD facilitates smoother and informed transitions from graduate school to postdoctoral and tenure-track positions, as well as other "first" jobs in academia, government, industry, and non-profit organizations. In 2011, the first conference for 18 doctoral candidate and recent graduates was hosted at the University of Texas at Arlington's (UTA) College of Science. Using a format of guest speakers, brown bag discussions, and interactive breakout sessions, participants engaged in sessions entitled "Toolkits for Success in Academia, Business and Industry, Federal Government and Non-Profits", "Defining Short, Mid and Long Term Career Goals", "Accessing and Refining Skill Sets and Other Door Openers", "International Preparation and Opportunities", "Paying it Forward/Lifting as You Climb", and "Customized Strategies for Next Steps". This presentation will discuss outcomes from this pilot project, the use of social media to track and support ongoing B-PhD activities, and objectives for future B-PhD workshops.

  1. Germ-line PHD1 and PHD2 mutations detected in patients with pheochromocytoma/paraganglioma-polycythemia.

    Science.gov (United States)

    Yang, Chunzhang; Zhuang, Zhengping; Fliedner, Stephanie M J; Shankavaram, Uma; Sun, Michael G; Bullova, Petra; Zhu, Roland; Elkahloun, Abdel G; Kourlas, Peter J; Merino, Maria; Kebebew, Electron; Pacak, Karel

    2015-01-01

    We have investigated genetic/pathogenetic factors associated with a new clinical entity in patients presenting with pheochromocytoma/paraganglioma (PHEO/PGL) and polycythemia. Two patients without hypoxia-inducible factor 2α (HIF2A) mutations, who presented with similar clinical manifestations, were analyzed for other gene mutations, including prolyl hydroxylase (PHD) mutations. We have found for the first time a germ-line mutation in PHD1 in one patient and a novel germ-line PHD2 mutation in a second patient. Both mutants exhibited reduced protein stability with substantial quantitative protein loss and thus compromised catalytic activities. Due to the unique association of patients' polycythemia with borderline or mildly elevated erythropoietin (EPO) levels, we also performed an in vitro sensitivity assay of erythroid progenitors to EPO and for EPO receptor (EPOR) expression. The results show inappropriate hypersensitivity of erythroid progenitors to EPO in these patients, indicating increased EPOR expression/activity. In addition, the present study indicates that HIF dysregulation due to PHD mutations plays an important role in the pathogenesis of these tumors and associated polycythemia. The PHD1 mutation appears to be a new member contributing to the genetic landscape of this novel clinical entity. Our results support the existence of a specific PHD1- and PHD2-associated PHEO/PGL-polycythemia disorder. • A novel germ-l i n e PHD1 mutation causing heochromocytoma/paraganglioma and polycythemia. • Increased EPOR activity and inappropriate hypersensitivity of erythroid progenitors to EPO.

  2. Pharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative.

    Science.gov (United States)

    Hendriks, Hans R; Govaerts, Anne-Sophie; Fichtner, Iduna; Burtles, Sally; Westwell, Andrew D; Peters, Godefridus J

    2017-07-11

    The European NCI compounds programme, a joint initiative of the EORTC Research Branch, Cancer Research Campaign and the US National Cancer Institute, was initiated in 1993. The objective was to help the NCI in reducing the backlog of in vivo testing of potential anticancer compounds, synthesised in Europe that emerged from the NCI in vitro 60-cell screen. Over a period of more than twenty years the EORTC-Cancer Research Campaign panel reviewed ∼2000 compounds of which 95 were selected for further evaluation. Selected compounds were stepwise developed with clear go/no go decision points using a pharmacologically directed programme. This approach eliminated quickly compounds with unsuitable pharmacological properties. A few compounds went into Phase I clinical evaluation. The lessons learned and many of the principles outlined in the paper can easily be applied to current and future drug discovery and development programmes. Changes in the review panel, restrictions regarding numbers and types of compounds tested in the NCI in vitro screen and the appearance of targeted agents led to the discontinuation of the European NCI programme in 2017 and its transformation into an academic platform of excellence for anticancer drug discovery and development within the EORTC-PAMM group. This group remains open for advice and collaboration with interested parties in the field of cancer pharmacology.

  3. DISSENYAR EXPERIÈNCIES AMB VALOR TURÍSTIC: PAISATGES URBANS

    Directory of Open Access Journals (Sweden)

    Francesc Fusté

    2015-10-01

    Full Text Available Aquest article tracta sobre les possibilitats que la creació d’experiències té en relació al desenvolupament empresarial i regional, gràcies a la tematització del sector turístic i la modificació intencional de l’entorn, tant cultural com natural. El paisatge caracteritza els espais en funció de la seva configuració territorial i també arquitectònica i urbana. Les estructures arquitectòniques, els esdeveniments i les activitats que impliquen la participació activa dels usuaris són la clau de l’èxit del disseny de les experiències amb un valor afegit, on les noves tecnologies ajuden a emfatitzar-ne l’impacte. Sigui com sigui, convertir els llocs en experiències tant pels residents com pels visitants.

  4. Seven steps towards a PhD in psychiatry.

    Science.gov (United States)

    Molina-Ruiz, Rosa María

    2016-12-01

    The present review aims to describe the main steps for completing a psychiatric PhD thesis with success. A selective review of the literature and the author's experience as a psychiatrist completing a PhD. Deciding upon a topic, choosing a mentor, organising your time, persevering and remaining motivated are the key elements. Preparedness and diligence lead the way towards a PhD. This advice is also relevant for those undertaking research at any stage of their career. © The Royal Australian and New Zealand College of Psychiatrists 2016.

  5. NIH and NCI grant-related changes during fiscal years 2014 and 2015

    Science.gov (United States)

    Wong, Rosemary S. L.

    2015-03-01

    The 2014 fiscal year (FY) continued to be a challenging one for all federal agencies despite the many Congressional strategies proposed to address the U.S. budget deficit. The Bipartisan Budget Act of 2013 passed by the House and Senate in December 2013 approved a two-year spending bill which cancelled the FY2014 and FY2015 required sequestration cuts (i.e., 4-5% National Institute of Health (NIH)/National Cancer Institute (NCI) budget reduction initiated on March 1, 2013), but extended the sequestration period through FY2023. This bill passage helped minimize any further budget reductions and resulted in a final FY2014 NIH budget of 29.9 billion and a NCI budget of 4.9 billion. Both NIH and NCI worked hard to maintain awarding the same number of NIH/NCI investigator-initiated R01 and exploratory R21 grants funded in FY2014 and similar to the level seen in FY2013 and previous years (see Tables 1 and 2). Since Congress only recently passed the 2015 spending bill in December 16, 2014, the final NIH and NCI budget appropriations for FY2015 remains unknown at this time and most likely will be similar to the FY2014 budget level. The NCI overall success and funding rates for unsolicited investigator-initiated R01 applications remained at 15%, while the success rate for exploratory R21 applications was 12% in FY2014 with similar rates seen in FY2013 (see Tables 1 and 2). The success rate for biomedical research applications in the Photodynamic Therapy and laser research field will be provided for the past few years. NIH provides numerous resources to help inform the extramural biomedical research community of new and current grant applicants about new grant policy changes and the grant submission and review processes.

  6. 77 FR 2734 - Proposed Collection; Comment Request: Solar Cell: A Mobile UV Manager for Smart Phones (NCI)

    Science.gov (United States)

    2012-01-19

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Proposed Collection; Comment Request: Solar Cell: A Mobile UV Manager for Smart Phones (NCI) SUMMARY: In compliance with the... Manager for Smart Phones (NCI). Type of Information Collection Request: New. Need and Use of Information...

  7. Meet EPA Natural Resource Economist Marisa Mazzotta, Ph.D.

    Science.gov (United States)

    Marisa Mazzotta, Ph.D. currently works as an Economist at EPA's Atlantic Ecology Division. Her research focuses on the public's valuation and prioritization of natural resources, and the relationship between ecological changes and economic benefits.

  8. Meet EPA Scientist Jordan West, Ph.D.

    Science.gov (United States)

    Jordan West, Ph.D. is an aquatic ecologist at EPA. Her areas of expertise include freshwater & marine ecology, climate change impacts and adaptation, resilience and threshold theory, environmental risk assessment, expert elicitation & stakeholder processes

  9. Meet EPA Scientist Susan Yee, Ph.D.

    Science.gov (United States)

    Susan Yee, Ph.D., is an ecologist at EPA's Gulf Ecology Division. She is working on the Puerto Rico Sustainable Communities program, developing decision support tools to evaluate how alternative decisions impact coastal ecosystem goods and services

  10. Meet EPA Engineer Shawn Ryan, Ph.D.

    Science.gov (United States)

    Shawn Ryan, Ph.D. is a chemical engineer at EPA's National Homeland Security Research Center. He has worked at EPA for 12 years, nine of which have been devoted to leading research to support decontamination and consequence management.

  11. Meet EPA Chemist Quincy Teng, Ph.D.

    Science.gov (United States)

    EPA research chemist Quincy Teng, Ph.D., focuses on the application of metabolomics—a relatively new, specialized field of biochemistry focused on studying small molecules known as metabolites—on environmental and life sciences.

  12. Meet EPA Scientist Jody Shoemaker, Ph.D.

    Science.gov (United States)

    EPA research chemist Jody Shoemaker, Ph.D., works to support Agency efforts to protect drinking water. She helps develop methods for analyzing organic chemicals on the Drinking Water Contaminant Candidate List (CCL).

  13. Meet EPA Environmental Engineer Terra Haxton, Ph.D.

    Science.gov (United States)

    EPA Environmental Engineer Terra Haxton, Ph.D., uses computer simulation models to protect drinking water. She investigates approaches to help water utilities be better prepared to respond to contamination incidents in their distribution systems.

  14. Meet EPA Scientist Jeff Szabo, Ph.D.

    Science.gov (United States)

    EPA scientist Jeff Szabo, Ph.D., has worked for the EPA’s National Homeland Security Research Center since 2005. He conducts and manages water security research projects at EPA’s Test and Evaluation facility.

  15. Meet EPA Scientist Tim Shafer, Ph.D.

    Science.gov (United States)

    Tim Shafer earned his bachelor’s degree in biology and chemistry from Hope College in Holland, MI, in 1986 and his Ph.D. in pharmacology and environmental toxicology from Michigan State University in 1991.

  16. Meet EPA Ecologist Paul Mayer, Ph.D.

    Science.gov (United States)

    EPA ecologist Paul Mayer, Ph.D. works in EPA's Groundwater and Ecosystem Restoration division where he studies riparian zones (the area along rivers and streams where the habitats are influenced by both the land and water) and stream restoration

  17. ebibliographical compilation of phd theses produced at the faculty

    African Journals Online (AJOL)

    USER

    2015-06-01

    Jun 1, 2015 ... comprehensive list of Ph.D theses produced by the following ... Science: Applied and Plant Biology, Micro-Biology, ... Communities. ... Water Purification Potentials and in-vivo ... Cultivation at Small-Hoiders Level in Semi.

  18. The PhD Conundrum in South African Academia

    Science.gov (United States)

    Breier, Mignonne; Herman, Chaya

    2017-01-01

    South African universities need more academics with PhDs, from historically disadvantaged population groups in particular, but they face a conundrum. In order to have more staff with PhDs, they need to produce more PhD graduates. But in order to produce more PhD graduates, they need more staff with PhDs to supervise. This article explores this…

  19. Reducing Friction: An Update on the NCIP Open Development Initiative - NCI BioMedical Informatics Blog

    Science.gov (United States)

    NCIP has migrated 132 repositories from the NCI subversion repository to our public NCIP GitHub channel with the goal of facilitating third party contributions to the existing code base. Within the GitHub environment, we are advocating use of the GitHub “fork and pull” model.

  20. NCI and the Chinese National Cancer Center pursue new collaborations in cancer research

    Science.gov (United States)

    CGH Director, Dr. Ted Trimble, and East Asia Program Director, Dr. Ann Chao, traveled to Beijing with Mr. Matthew Brown from the Department of Health and Human Services Office of Global Affairs to attend the Joint Meeting of the NCC and the U.S. NCI.

  1. 78 FR 53763 - Proposed Collection; 60-day Comment Request Cancer Trials Support Unit (CTSU) (NCI)

    Science.gov (United States)

    2013-08-30

    ... proposed data collection projects, the National Cancer Institute (NCI), National Institutes of Health (NIH), will publish periodic summaries of proposed projects to be submitted to the Office of Management and... proposed collection of information, including the validity of the methodology and assumptions used; (3...

  2. NCI at Frederick Employees Receive Awards at the Spring Research Festival | Poster

    Science.gov (United States)

    NCI and Frederick National Laboratory staff members were among those honored at the Spring Research Festival Awards Ceremony on May 28. The ceremony was the culmination of the festival, which was sponsored by the National Interagency Confederation for Biological Research (NICBR), May 4–7. Maj. Gen. Brian Lein, commanding general, U.S. Army Medical Research and Materiel Command

  3. Microsoft Office 365 Deployment Continues through June at NCI at Frederick | Poster

    Science.gov (United States)

    The latest Microsoft suite, Office 365 (O365), is being deployed to all NCI at Frederick computers during the months of May and June to comply with federal mandates. The suite includes the latest versions of Word, Excel, Outlook, PowerPoint, and Skype for Business, along with cloud-based capabilities. These cloud-based capabilities will help meet the federal mandates that

  4. Puerto Rico NCI Community Oncology Research Program Minority/Underserved | Division of Cancer Prevention

    Science.gov (United States)

    The Puerto Rico NCI Community Oncology Research Program (PRNCORP) will be the principal organization in the island that promotes cancer prevention, control and screening/post-treatment surveillance clinical trials. It will conduct cancer care delivery research and will provide access to treatment and imaging clinical trials conducted under the reorganization of the National

  5. 75 FR 61763 - Submission of OMB Review; Comment Request; Drug Accountability Record (Form NIH 2564) (NCI)

    Science.gov (United States)

    2010-10-06

    ...; Comment Request; Drug Accountability Record (Form NIH 2564) (NCI) SUMMARY: In compliance with the..., 2011, unless it displays a valid OMB control number. Proposed Collection: Title: Drug Accountability... accountability. In order to fulfill these requirements, a standard Investigational Drug Accountability Report...

  6. 75 FR 46945 - Proposed Collection; Comment Request; the Drug Accountability Record (Form NIH 2564) (NCI)

    Science.gov (United States)

    2010-08-04

    ... Request; the Drug Accountability Record (Form NIH 2564) (NCI) SUMMARY: In compliance with the requirement... Management and Budget (OMB) for review and approval. Proposed Collection Title: The Drug Accountability... agent accountability. In order to fulfill these requirements, a standard Investigational Drug...

  7. 76 FR 14034 - Proposed Collection; Comment Request; NCI Cancer Genetics Services Directory Web-Based...

    Science.gov (United States)

    2011-03-15

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Proposed Collection; Comment Request; NCI Cancer Genetics Services Directory Web-Based Application Form and Update Mailer Summary: In... Cancer Genetics Services Directory Web-based Application Form and Update Mailer. [[Page 14035

  8. The generalizability of NCI-sponsored clinical trials accrual among women with gynecologic malignancies.

    Science.gov (United States)

    Mishkin, Grace; Minasian, Lori M; Kohn, Elise C; Noone, Anne-Michelle; Temkin, Sarah M

    2016-12-01

    Enrollment of a representative population to cancer clinical trials ensures scientific reliability and generalizability of results. This study evaluated the similarity of patients enrolled in NCI-supported group gynecologic cancer trials to the incident US population. Accrual to NCI-sponsored ovarian, uterine, and cervical cancer treatment trials between 2003 and 2012 were examined. Race, ethnicity, age, and insurance status were compared to the analogous US patient population estimated using adjusted SEER incidence data. There were 18,913 accruals to 156 NCI-sponsored gynecologic cancer treatment trials, ovarian (56%), uterine (32%), and cervical cancers (12%). Ovarian cancer trials included the least racial, ethnic and age diversity. Black women were notably underrepresented in ovarian trials (4% versus 11%). Hispanic patients were underrepresented in ovarian and uterine trials (4% and 5% versus 18% and 19%, respectively), but not in cervical cancer trials (14 versus 11%). Elderly patients were underrepresented in each disease area, with the greatest underrepresentation seen in ovarian cancer patients over the age of 75 (7% versus 29%). Privately insured women were overrepresented among accrued ovarian cancer patients (87% versus 76%), and the uninsured were overrepresented among women with uterine or cervical cancers. These patterns did not change over time. Several notable differences were observed between the patients accrued to NCI funded trials and the incident population. Improving representation of racial and ethnic minorities and elderly patients on cancer clinical trials continues to be a challenge and priority. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. 78 FR 2678 - Proposed Collection; Comment Request (60-Day FRN): The National Cancer Institute (NCI...

    Science.gov (United States)

    2013-01-14

    ... Request (60-Day FRN): The National Cancer Institute (NCI) SmokefreeTXT (Text Message) Program Evaluation..., Behavioral Scientist/ Health Science Administrator, Division of Cancer Control and Population Sciences, 6130... text message smoking cessation intervention designed for young adult smokers ages 18-29. The Smokefree...

  10. Paracytosis of Haemophilus influenzae through cell layers of NCI-H292 lung epithelial cells

    NARCIS (Netherlands)

    van Schilfgaarde, M.; van Alphen, L.; Eijk, P.; Everts, V.; Dankert, J.

    1995-01-01

    Haemophilus influenzae penetrates the respiratory epithelium during carriage and invasive disease, including respiratory tract infections. We developed an in vitro model system consisting of lung epithelial NCI-H292 cells on permeable supports to study the passage of H. influenzae through lung

  11. NCI Statement on the U.S. Surgeon General's "Call to Action to Prevent Skin Cancer"

    Science.gov (United States)

    As the Federal Government's principal agency for cancer research and training, the National Cancer Institute (NCI) endorses the U.S. Surgeon General’s “Call to Action to Prevent Skin Cancer,” which provides a comprehensive evaluation of the current state of skin cancer prevention efforts in the United States and recommends actions for improvement in the future.

  12. PhD students: making research and publishing

    Directory of Open Access Journals (Sweden)

    Ioan Sporea, MD, PhD

    2016-12-01

    Full Text Available PhD student time is very interesting in the life of researchers. Many of them are young graduates, without or with very few experience in the field of scientific research. During four years, they must become experts in a narrow field (virtually, the subject of their PhD thesis, but at the same time they have to be trained for research and for publishing. Is it possible? It is mandatory! PhD students start with a one year training in the basic field of research during which they attend different courses regarding how to search the literature, how to perform research, how to perform statistical analysis, how to prepare a paper, where and how to publish and so on. Following this training year, together with their mentor (the coordinator of the PhD thesis, the PhD student starts working on the thesis. And this means reading as much as possible significant published data regarding his/her subject, proper research (basic, experimental, or clinical, and finally preparing papers for publication (in the beginning as abstracts for different meetings and later as original articles in dedicated journals.Participation of PhD students to different meetings is important to improve the quality of their research as an exercise for oral presentations. On the other hand, oral presentation is useful because the paper is open for discussion and corrections can be made during and after the oral presentation. During last ten years, there were organized conferences for PhD students and young doctors, particularly in Târgu Mureș and Timișoara. It was a good opportunity to show results, to discuss and to cooperate.This is why in December 2016, the Doctoral School of Victor Babes University of Medicine and Pharmacy decided to organize a scientific competition between PhD students, in an interesting scientific session. The top 10 PhD students (according to the cumulative Impact Factor of their first author publications were invited to present their scientific research

  13. The Production Rate and Employment of Ph.D. Astronomers

    Science.gov (United States)

    Metcalfe, Travis S.

    2008-02-01

    In an effort to encourage self-regulation of the astronomy job market, I examine the supply of, and demand for, astronomers over time. On the supply side, I document the production rate of Ph.D. astronomers from 1970 to 2006 using the UMI Dissertation Abstracts database, along with data from other independent sources. I compare the long-term trends in Ph.D. production with federal astronomy research funding over the same time period, and I demonstrate that additional funding is correlated with higher subsequent Ph.D. production. On the demand side, I monitor the changing patterns of employment using statistics about the number and types of jobs advertised in the AAS Job Register from 1984 to 2006. Finally, I assess the sustainability of the job market by normalizing this demand by the annual Ph.D. production. The most recent data suggest that there are now annual advertisements for about one postdoctoral job, half a faculty job, and half a research/support position for every new domestic Ph.D. recipient in astronomy and astrophysics. The average new astronomer might expect to hold up to 3 jobs before finding a steady position.

  14. PhD Dissertations Tesi di dottorato

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2003-12-01

    Full Text Available Report of PhD Dissertations.Guido Antonioli Conservator pacis et iustitie. La signoria di Taddeo Pepoli a Bologna (1337-1347, Tesi di dottorato di ricerca in Filologia romanza e cultura medievale (XIII ciclo, Università degli Studi di Bologna, 2001   Elisabetta Filippini «In vassallatico episcopi permanere debent». Rapporti vassallatici e concessioni beneficiali dei vescovi di Cremona fra X e XIII secolo, Tesi di dottorato di Ricerca in Storia Medievale (XV ciclo, Università Cattolica del Sacro Cuore di Milano, 2003   Marco Meschini, Innocenzo III e il "negotium pacis et fidei" in Linguadoca tra il 1198 e il 1215, Tesi di dottorato di ricerca in Storia medievale, Università Cattolica del Sacro Cuore, 2003   Fabrizio Ricciardelli The Politics of Exclusion in Florence (1215-1434, thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in History, University of Warwick, Department of History, April 2003 Renata Salvarani Baptizare pueros et decimas dare. Cura delle anime, strutturazione ecclesiastica e organizzazione delle campagne in area gardesana fra VIII e XIII secolo (diocesi di Brescia, Verona, Mantova e Trento, Tesi di dottorato in Storia medievale (XV ciclo, Università Cattolica del Sacro Cuore di Milano, 2002-2003   Vito Sibilio Le parole della prima crociata, Tesi di dottorato di ricerca in Storia dei centri delle vie e della cultura dei pellegrinaggi nel medioevo euromediterraneo, Università degli studi di Lecce, 2003Segnalazione di tesi di dottorato. Guido Antonioli Conservator pacis et iustitie. La signoria di Taddeo Pepoli a Bologna (1337-1347, Tesi di dottorato di ricerca in Filologia romanza e cultura medievale (XIII ciclo, Università degli Studi di Bologna, 2001   Elisabetta Filippini «In vassallatico episcopi permanere debent». Rapporti vassallatici e concessioni beneficiali dei vescovi di Cremona fra X e XIII secolo, Tesi di dottorato di Ricerca in Storia Medievale (XV

  15. CellMiner: a relational database and query tool for the NCI-60 cancer cell lines

    Directory of Open Access Journals (Sweden)

    Reinhold William C

    2009-06-01

    Full Text Available Abstract Background Advances in the high-throughput omic technologies have made it possible to profile cells in a large number of ways at the DNA, RNA, protein, chromosomal, functional, and pharmacological levels. A persistent problem is that some classes of molecular data are labeled with gene identifiers, others with transcript or protein identifiers, and still others with chromosomal locations. What has lagged behind is the ability to integrate the resulting data to uncover complex relationships and patterns. Those issues are reflected in full form by molecular profile data on the panel of 60 diverse human cancer cell lines (the NCI-60 used since 1990 by the U.S. National Cancer Institute to screen compounds for anticancer activity. To our knowledge, CellMiner is the first online database resource for integration of the diverse molecular types of NCI-60 and related meta data. Description CellMiner enables scientists to perform advanced querying of molecular information on NCI-60 (and additional types through a single web interface. CellMiner is a freely available tool that organizes and stores raw and normalized data that represent multiple types of molecular characterizations at the DNA, RNA, protein, and pharmacological levels. Annotations for each project, along with associated metadata on the samples and datasets, are stored in a MySQL database and linked to the molecular profile data. Data can be queried and downloaded along with comprehensive information on experimental and analytic methods for each data set. A Data Intersection tool allows selection of a list of genes (proteins in common between two or more data sets and outputs the data for those genes (proteins in the respective sets. In addition to its role as an integrative resource for the NCI-60, the CellMiner package also serves as a shell for incorporation of molecular profile data on other cell or tissue sample types. Conclusion CellMiner is a relational database tool for

  16. The Training and Work of Ph.D. Physical Scientists

    Science.gov (United States)

    Smith, S. J.; Schweitzer, A. E.

    2003-05-01

    Doctoral education has often been viewed as the pinnacle of the formal education system. How useful is doctoral training in one's later career? In an NSF-funded project, we set out to perform a study of the training, careers, and work activities of Ph.D. physical scientists. The study included both in-depth interviews and a survey sent out to a sample of Ph.D. holders 4-8 years after graduation. Come and find out the results of this study: What skills are most Ph.D. physical scientists using? What should graduate programs be teaching? Are Ph.D.'s who are working in their specific field of training happier than their counterparts working different jobs? What skills and preparation lead to future job satisfaction, perhaps the most important indicator of the "success" of graduate education? A preprint and further details can be found at the project web site at: spot.colorado.edu/ phdcarer.

  17. Dido3 PHD Modulates Cell Differentiation and Division

    Directory of Open Access Journals (Sweden)

    Jovylyn Gatchalian

    2013-07-01

    Full Text Available Death Inducer Obliterator 3 (Dido3 is implicated in the maintenance of stem cell genomic stability and tumorigenesis. Here, we show that Dido3 regulates the expression of stemness genes in embryonic stem cells through its plant homeodomain (PHD finger. Binding of Dido3 PHD to histone H3K4me3 is disrupted by threonine phosphorylation that triggers Dido3 translocation from chromatin to the mitotic spindle. The crystal structure of Dido3 PHD in complex with H3K4me3 reveals an atypical aromatic-cage-like binding site that contains a histidine residue. Biochemical, structural, and mutational analyses of the binding mechanism identified the determinants of specificity and affinity and explained the inability of homologous PHF3 to bind H3K4me3. Together, our findings reveal a link between the transcriptional control in embryonic development and regulation of cell division.

  18. Proceedings of the ICTSS 2012 PhD Workshop - Preface

    DEFF Research Database (Denmark)

    Nielsen, Brian; Weise, Carsten

    2012-01-01

    and their thesis work and receive constructive feedback from experts in the field as well as from peers. Also it is an opportunity for researchers to get an insight into new research topics in the field. Ph.D. students at any stage of their doctoral studies may participate. Seven abstracts were submitted......This technical report contains the proceedings of the Ph.D. Workshop held in conjunction with the The 24th IFIP Int. Conference on Testing Software and Systems (ICTSS'12) in Aalborg, Denmark, November 19, 2012. The well‐established ICTSS series of international conferences addresses the conceptual......, theoretic, and practical challenges of testing software systems, including communication protocols, services, distributed platforms, middleware, embedded systems, and security infrastructures. The aims of the ICTSS Doctoral Workshop is to provide a forum for PhD students to present preliminary results...

  19. Genome-Wide Identification and Analysis of Genes Encoding PHD-Finger Protein in Tomato

    International Nuclear Information System (INIS)

    Hayat, S.; Cheng, Z.; Chen, X.

    2016-01-01

    The PHD-finger proteins are conserved in eukaryotic organisms and are involved in a variety of important functions in different biological processes in plants. However, the function of PHD fingers are poorly known in tomato (Solanum lycopersicum L.). In current study, we identified 45 putative genes coding Phd finger protein in tomato distributed on 11 chromosomes except for chromosome 8. Some of the genes encode other conserved key domains besides Phd-finger. Phylogenetic analysis of these 45 proteins resulted in seven clusters. Most Phd finger proteins were predicted to PML body location. These PHD-finger genes displayed differential expression either in various organs, at different development stages and under stresses in tomato. Our study provides the first systematic analysis of PHD-finger genes and proteins in tomato. This preliminary study provides a very useful reference information for Phd-finger proteins in tomato. They will be helpful for cloning and functional study of tomato PHD-finger genes. (author)

  20. Researcher Profile: An Interview with Sarah Asebedo, Ph.D.

    Directory of Open Access Journals (Sweden)

    Martie Gillen

    2016-12-01

    Full Text Available Sarah Asebedo, Ph.D., CFP®, is an Assistant Professor of Personal Financial Planning with Texas Tech University. With extensive financial planning practitioner experience, her goal is to connect research and financial planning practice with a focus on the relationship between psychological attributes, financial conflicts, and financial behavior. Her work has been published in the Journal of Financial Planning, Journal of Financial Therapy, Journal of Financial Counseling and Planning, and Financial Planning Review. Asebedo currently serves as President-Elect for the Financial Therapy Association. She earned her Ph.D. in Personal Financial Planning from Kansas State University.

  1. Survey on the Labour Market Position of PhD Graduates: Competence comparison and relation between PhD and current employment

    Energy Technology Data Exchange (ETDEWEB)

    Heuritsch, J.; Waaijer, C.J.F.; Van der Weijden, I.C.M.

    2016-07-01

    We compared the skills PhD graduates acquired during their PhDs to the ones they need in their current job. We also studied the relation between PhD topic and content of the current job of recent PhD graduates. Data was collected in a survey of 1,133 respondents with a PhD from five Dutch universities between early 2008 and mid-2012. We show that scientific skills and independence are developed sufficiently during the PhD education, whereas PhDs are lacking in management and communication skills. These competence discrepancies were compared to the educational level required for the PhD holder’s current job and the relatedness of the current job to the PhD topic. (Author)

  2. PhD Dissertations Tesi di dottorato

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2004-06-01

    Full Text Available

    Report of PhD Dissertations.

    Francesco Barone

    Istituzioni, società ed economia a Catania nel tardo medioevo (XIV-XV secolo, Tesi di dottorato in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004

     

    Laura Berti Ceroni

    Il territorio e le strutture di Cesarea e Classe tra tarda antichità e alto medioevo in rapporto con Ravenna, Tesi di dottorato di ricerca in Storia e Informatica, Università degli studi di Bologna, 2002-2003.

     

    Marco Bicchierai

    Poppi dalla signoria dei conti Guidi al vicariato del Casentino (1360-1480, Tesi di dottorato in Storia medievale (XIV ciclo, Università degli Studi di Firenze, 2004

     

    Emanuela Garimberti

    Spatiosa ad habitandum loca. Luoghi e identità nella Historia Langobardorum di Paolo Diacono, Tesi di dottorato in Storia medievale (XV ciclo, Università degli Studi di Bologna, 2004

     

    Lorenzo Tanzini

    Sistemi normativi e pratiche istituzionali a Firenze dalla fine del XIII all’inizio del XV secolo, Tesi di dottorato di ricerca in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004

     

    Stefania Tarquini

    Pellegrinaggio e asseto urbano di Roma, Tesi di dottorato di ricerca in Storia dei centri, delle vie e della cultura dei pellegrinaggi nel Medioevo euro mediterraneo (XV ciclo, Università degli studi di Lecce, 2003

    Segnalazione di tesi di dottorato.

    Francesco Barone

    Istituzioni, società ed economia a Catania nel tardo medioevo (XIV-XV secolo, Tesi di dottorato in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004

     

    Laura Berti Ceroni

  3. Analysis of 125I-[Tyr3] octreotide receptors of NCI-H466 cell line

    International Nuclear Information System (INIS)

    Sun Junjie; Fan Wo; Xu Yujie; Zhang Youjiu; Zhu Ran

    2002-01-01

    Objective: To study the affinity of small cell lung carcinoma to [Tyr 3 ] octreotide (TOC). Methods: Taking 125 I-[Tyr 3 ] octreotide (labeled by chloramine-T method), as the ligand, small cell lung carcinoma NCI-H466 cell line was inspected for the receptor-binding points and affinity constant. Results: The radio-chemical purity of 125 I-TOC purified through sephadex G-10 was higher than 95%. Receptor analysis study showed that the expression of somatostatin receptors on NCI-H446 cells was numerous (Bmax = 1.17 x 10 5 /cell) with strong affinity to 125 I-TOC (Kd = 0.56 nM). Conclusion: Labeled TOC could be used for small cell lung carcinoma receptor imaging and radio-pharmaceutical therapy

  4. 77 FR 4334 - Proposed Collection; Comment Request; Solar Cell: A Mobile UV Manager for Smart Phones (NCI)

    Science.gov (United States)

    2012-01-27

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Proposed Collection; Comment Request; Solar Cell: A Mobile UV Manager for Smart Phones (NCI) SUMMARY: In compliance with the... Manager for Smart Phones [[Page 4335

  5. It’s Easy to Recycle at NCI at Frederick | Poster

    Science.gov (United States)

    From 2013 through the first quarter of 2018, NCI at Frederick has recycled over 1,667 tons of material, while incinerating or landfilling over 4,273 tons of trash. This earns us a recycling rate close to 28 percent, which is below the national average of 32 percent, according to the Environmental Protection Agency, and well below our goal of 50 percent. (These numbers only

  6. NCI Think Tank Concerning the Identifiability of Biospecimens and “-Omic” Data

    OpenAIRE

    Weil, Carol J.; Mechanic, Leah E.; Green, Tiffany; Kinsinger, Christopher; Lockhart, Nicole C.; Nelson, Stefanie A.; Rodriguez, Laura L.; Buccini, Laura D.

    2013-01-01

    On June 11 and 12, 2012, the National Cancer Institute (NCI) hosted a think tank concerning the identifiability of biospecimens and “omic” Data in order to explore challenges surrounding this complex and multifaceted topic. The think tank brought together forty-six leaders from several fields, including cancer genomics, bioinformatics, human subject protection, patient advocacy, and commercial genetics. The first day involved presentations regarding the state of the science of re-identificati...

  7. A Gene-Based Prognostic for Hepatocellular Carcinoma Patient Response to Adjuvant Transcatheter Arterial Chemoembolization | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The gold standard of care for hepatocellular carcinoma patients with intermediate- to locally advanced tumors is transcatheter arterial chemoembolization (TACE), a procedure whereby the tumor is targeted both with local chemotherapy and restriction of local blood supply. NCI scientists have identified a 14-gene signature predictive of response to TACE, and NCI seeks licensees or co-development partners to develop the technology toward commercialization.

  8. Best Performers Announced for the NCI-CPTAC DREAM Proteogenomics Computational Challenge | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium (CPTAC) is pleased to announce that teams led by Jaewoo Kang (Korea University), and Yuanfang Guan with Hongyang Li (University of Michigan) as the best performers of the NCI-CPTAC DREAM Proteogenomics Computational Challenge. Over 500 participants from 20 countries registered for the Challenge, which offered $25,000 in cash awards contributed by the NVIDIA Foundation through its Compute the Cure initiative.

  9. Spatial patterns of FUS-immunoreactive neuronal cytoplasmic inclusions (NCI) in neuronal intermediate filament inclusion disease (NIFID).

    Science.gov (United States)

    Armstrong, Richard A; Gearing, Marla; Bigio, Eileen H; Cruz-Sanchez, Felix F; Duyckaerts, Charles; Mackenzie, Ian R A; Perry, Robert H; Skullerud, Kari; Yokoo, Hideaki; Cairns, Nigel J

    2011-11-01

    Neuronal intermediate filament inclusion disease (NIFID), a rare form of frontotemporal lobar degeneration (FTLD), is characterized neuropathologically by focal atrophy of the frontal and temporal lobes, neuronal loss, gliosis, and neuronal cytoplasmic inclusions (NCI) containing epitopes of ubiquitin and neuronal intermediate filament (IF) proteins. Recently, the 'fused in sarcoma' (FUS) protein (encoded by the FUS gene) has been shown to be a component of the inclusions of NIFID. To further characterize FUS proteinopathy in NIFID, we studied the spatial patterns of the FUS-immunoreactive NCI in frontal and temporal cortex of 10 cases. In the cerebral cortex, sectors CA1/2 of the hippocampus, and the dentate gyrus (DG), the FUS-immunoreactive NCI were frequently clustered and the clusters were regularly distributed parallel to the tissue boundary. In a proportion of cortical gyri, cluster size of the NCI approximated to those of the columns of cells was associated with the cortico-cortical projections. There were no significant differences in the frequency of different types of spatial patterns with disease duration or disease stage. Clusters of NCI in the upper and lower cortex were significantly larger using FUS compared with phosphorylated, neurofilament heavy polypeptide (NEFH) or α-internexin (INA) immunohistochemistry (IHC). We concluded: (1) FUS-immunoreactive NCI exhibit similar spatial patterns to analogous inclusions in the tauopathies and synucleinopathies, (2) clusters of FUS-immunoreactive NCI are larger than those revealed by NEFH or ΙΝΑ, and (3) the spatial patterns of the FUS-immunoreactive NCI suggest the degeneration of the cortico-cortical projections in NIFID.

  10. The NCI Alliance for Nanotechnology in Cancer: achievement and path forward.

    Science.gov (United States)

    Ptak, Krzysztof; Farrell, Dorothy; Panaro, Nicholas J; Grodzinski, Piotr; Barker, Anna D

    2010-01-01

    Nanotechnology is a 'disruptive technology', which can lead to a generation of new diagnostic and therapeutic products, resulting in dramatically improved cancer outcomes. The National Cancer Institute (NCI) of National Institutes of Health explores innovative approaches to multidisciplinary research allowing for a convergence of molecular biology, oncology, physics, chemistry, and engineering and leading to the development of clinically worthy technological approaches. These initiatives include programmatic efforts to enable nanotechnology as a driver of advances in clinical oncology and cancer research, known collectively as the NCI Alliance for Nanotechnology in Cancer (ANC). Over the last 5 years, ANC has demonstrated that multidisciplinary approach catalyzes scientific developments and advances clinical translation in cancer nanotechnology. The research conducted by ANC members has improved diagnostic assays and imaging agents, leading to the development of point-of-care diagnostics, identification and validation of numerous biomarkers for novel diagnostic assays, and the development of multifunctional agents for imaging and therapy. Numerous nanotechnology-based technologies developed by ANC researchers are entering clinical trials. NCI has re-issued ANC program for next 5 years signaling that it continues to have high expectations for cancer nanotechnology's impact on clinical practice. The goals of the next phase will be to broaden access to cancer nanotechnology research through greater clinical translation and outreach to the patient and clinical communities and to support development of entirely new models of cancer care.

  11. PhD Dissertations Tesi di dottorato

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2005-12-01

    Full Text Available Report of PhD Dissertations.Anna Airò La scrittura delle regole. Politica e istituzioni a Taranto nel Quattrocento, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 Pasquale Arfé La Clavis Physicae II (316-529 di Honorius Augustodunensis. Studio ed edizione critica, Tesi di dottorato in Storia della filosofia medievale, Università degli Studi di Napoli "L'Orientale", 2005 Alessandro Azzimonti Scrittura agiografica e strutture di potere nell'Italia centro-settentrionale (X-XII secolo, Tesi di dottorato di ricerca in Forme del sapere storico dal medioevo alla contemporaneità, Università degli Studi di Trieste, 2004 Domenico Cerami Il "Confine conteso". Uomini, istituzioni, culture a Monteveglio tra VIII-XII secolo, Tesi di dottorato di ricerca in Storia Medievale, Università degli studi di Bologna, 2005 Federica Chilà Ostaggi. Uno strumento di pacificazione e governo tra i secoli VIII e XII, Tesi di dottorato di ricerca in Istituzioni, società, religioni dal Tardo Antico alla fine del Medioevo, Università degli Studi di Torino, 2004 Enrico Faini Firenze nei secoli X-XIII: economia e società, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005Alessio FioreStrutture e pratiche del potere signorile in area umbro-marchigiana (secoli XI-XIII, Tesi di dottorato ricerca in Storia, Università degli studi di Pisa, 2004Giampaolo FrancesconiTra Riforma, vescovo e clientes. Camaldoli e le società locali (secoli XI-XIII, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 [09/05] Giuseppe Gardoni "Episcopus et potestas". Vescovi e società a Mantova nella prima metà del Duecento, Tesi di dottorato di ricerca in Storia del Cristianesimo e delle Chiese (antichità, medioevo, età moderna, Università degli Studi di Padova, 2005 Nicola Mancassola La gestione delle campagne tra Langobardia e Romània in età carolingia e post

  12. Peer Mentorship and Transformational Learning: PhD Student Experiences

    Science.gov (United States)

    Preston, Jane P.; Ogenchuk, Marcella J.; Nsiah, Joseph K.

    2014-01-01

    The purpose of the paper is to describe our peer mentorship experiences and explain how these experiences fostered transformational learning during our PhD graduate program in educational administration. As a literature backdrop, we discuss characteristics of traditional forms of mentorship and depict how our experiences of peer mentorship was…

  13. Ph.D Afhandling: Restaurering verus instaurering og transstaurering

    DEFF Research Database (Denmark)

    Bech-Nielsen, Grith

    2012-01-01

    Ph.d. afhandlingen udforsker holdningen som arkitektfagligt instrument. Fagudøverens "holdning" til værdisætning af arkitektoniske kulturarvsobjekter og til arkitektonisk intervention heri fungerer aktuelt som et anerkendt og konstituerende beslutningsinstrument i praksisnære processer og sammenh...

  14. Governance mode choice in collaborative Ph.D. projects

    NARCIS (Netherlands)

    Salimi, N.; Bekkers, R.N.A.; Frenken, K.

    2015-01-01

    Joint Ph.D. projects are a prominent form of research collaboration, connecting universities to firms and public research organizations. When entering into such collaborations, partners need to make choices regarding a project’s governance. This paper investigates how a university and its partners

  15. Governance mode choice in collaborative PhD projects

    NARCIS (Netherlands)

    Salimi, N.; Bekkers, R.N.A.; Frenken, K.

    2013-01-01

    Joint PhD projects are a promising form of research collaboration, connecting universities to firms and public research organizations. Entering into such collaborations, however, requires decisions in terms of governance. This paper investigates how a university and its partners govern such

  16. PhD by Publication: A Student's Perspective

    Directory of Open Access Journals (Sweden)

    Peter Kanowski

    2008-01-01

    Full Text Available This article presents the first author's experiences as an Australian doctoral student undertaking a PhD by publication in the arena of the social sciences. She published nine articles in refereed journals and a peer-reviewed book chapter during the course of her PhD. We situate this experience in the context of current discussion about doctoral publication practices, in order to inform both postgraduate students and academics in general. The article discusses recent thinking about PhD by publication and identifies the factors that students should consider prior to adopting this approach, in terms of university requirements, supervisors' attitudes, the research subject matter, intellectual property, capacity and working style, and issues of co-authorship. It then outlines our perceptions of the advantages and disadvantages of undertaking a PhD by publication. We suggest that, in general, the advantages outweigh the disadvantages. We conclude by reflecting on how the first author's experiences relate to current discussions about fostering publications by doctoral students.

  17. Consistency and Inconsistency in PhD Thesis Examination

    Science.gov (United States)

    Holbrook, Allyson; Bourke, Sid; Lovat, Terry; Fairbairn, Hedy

    2008-01-01

    This is a mixed methods investigation of consistency in PhD examination. At its core is the quantification of the content and conceptual analysis of examiner reports for 804 Australian theses. First, the level of consistency between what examiners say in their reports and the recommendation they provide for a thesis is explored, followed by an…

  18. Enhancing the skills of PhD supervisors facing internationalization

    DEFF Research Database (Denmark)

    Bøgelund, Pia

    2013-01-01

    interview study within the faculty, and an inquiry into the field of cross-cultural supervision with the purpose of enhancing the skills of PhD supervisors. As is often the case with cross-cultural exchange and inquiry, the study ended up by being just as informative on the supervision cultures and settings...

  19. Measures for Ph.D. Evaluation: The Recruitment Process

    Science.gov (United States)

    D'Agostino, Antonella; Fruzzetti, Stefania; Ghellini, Giulio; Neri, Laura

    2011-01-01

    In the last years the quality of Higher Education (HE) system and its evaluation have been key issues of the political and scientific debate on education policies all over Europe. In the wide landscape that involves the entire HE system we draw attention on the third level of its organization, i.e. the Ph.D. In particular, this paper discusses the…

  20. Supervising the PhD: A Guide to Success.

    Science.gov (United States)

    Delamont, Sara; Atkinson, Paul; Parry, Odette

    This handbook is a practical guide for the novice and experienced supervisor of Ph.D. students focusing on the British system. The book is organized to follow the progress of a student from starting out to a career after the viva voce examination. The chapters are: (1) "A Most Persuasive Piece of Argument"; (2) "Caught and Held by a…

  1. Ph.d. report nº1

    DEFF Research Database (Denmark)

    Hernandez, Lorenzo Banos

    The following report serves as an introduction to the Ph.d subject "Control system Modeling of the Wave Star Energy's Power Take-O". The device studied belongs to the Wave Energy field, which forms part of the renewable hydro Power generation sector. In Denmark, following the succesful course...

  2. PhD thesis: The relationship between expertise and creativity

    DEFF Research Database (Denmark)

    Boysen, Mikkel Snorre Wilms

    2015-01-01

    I Ph.d. projektet undersøges sammenhænge mellem ekspertise og kreativitet via et eksperiment, hvor eksperter og novicer laver musik ved computer. Musikken vurderes efterfølgende af en række fokusgrupper. Studiet peger overraskende på, at novicer på linje med eksperter er i stand til at skabe musi...

  3. PhD Students, Interculturality, Reflexivity, Community and Internationalisation

    Science.gov (United States)

    Holliday, Adrian

    2017-01-01

    Interviews with a small group of doctoral students at a British university indicate that the students feel that the programme provides an environment within which they develop interculturality through reflexive engagement with the PhD community and in some cases with the participants in their research. Significant here is that they are…

  4. PHD-2 Suppression in Mesenchymal Stromal Cells Enhances Wound Healing.

    Science.gov (United States)

    Ko, Sae Hee; Nauta, Allison C; Morrison, Shane D; Hu, Michael S; Zimmermann, Andrew S; Chung, Michael T; Glotzbach, Jason P; Wong, Victor W; Walmsley, Graham G; Peter Lorenz, H; Chan, Denise A; Gurtner, Geoffrey C; Giaccia, Amato J; Longaker, Michael T

    2018-01-01

    Cell therapy with mesenchymal stromal cells is a promising strategy for tissue repair. Restoration of blood flow to ischemic tissues is a key step in wound repair, and mesenchymal stromal cells have been shown to be proangiogenic. Angiogenesis is critically regulated by the hypoxia-inducible factor (HIF) superfamily, consisting of transcription factors targeted for degradation by prolyl hydroxylase domain (PHD)-2. The aim of this study was to enhance the proangiogenic capability of mesenchymal stromal cells and to use these modified cells to promote wound healing. Mesenchymal stromal cells harvested from mouse bone marrow were transduced with short hairpin RNA (shRNA) against PHD-2; control cells were transduced with scrambled shRNA (shScramble) construct. Gene expression quantification, human umbilical vein endothelial cell tube formation assays, and wound healing assays were used to assess the effect of PHD knockdown mesenchymal stromal cells on wound healing dynamics. PHD-2 knockdown mesenchymal stromal cells overexpressed HIF-1α and multiple angiogenic factors compared to control (p cells treated with conditioned medium from PHD-2 knockdown mesenchymal stromal cells exhibited increased formation of capillary-like structures and enhanced migration compared with human umbilical vein endothelial cells treated with conditioned medium from shScramble-transduced mesenchymal stromal cells (p cells healed at a significantly accelerated rate compared with wounds treated with shScramble mesenchymal stromal cells (p cells (p cells augments their proangiogenic potential in wound healing therapy. This effect appears to be mediated by overexpression of HIF family transcription factors and up-regulation of multiple downstream angiogenic factors.

  5. A model perception on the independence of PhD students in ...

    African Journals Online (AJOL)

    Rwandan Journal of Education ... As results, we suggest that a well-trained independent PhD student from UR should be able to think critically, to initiate, to innovate and to enhance the research capabilities. Therefore ... Keywords: PhD supervision, independent researcher, PhD student, research capability, critical thinking ...

  6. How Prepared Are MSW Graduates for Doctoral Research? Views of PhD Research Faculty

    Science.gov (United States)

    Drisko, James W.; Evans, Kristin

    2018-01-01

    This national survey of PhD faculty assessed the research preparation of entering doctoral social work students on a wide range of research knowledge and related skills. The prior literature shows that PhD programs repeat much BSW and MSW research course content. This study shows that the trend continues and has perhaps widened. PhD research…

  7. Qualitative methods in PhD theses from general practice in Scandinavia

    DEFF Research Database (Denmark)

    Malterud, Kirsti; Hamberg, Katarina; Reventlow, Susanne

    2017-01-01

    . Qualitative studies are often included in Ph.D. theses from general practice in Scandinavia. Still, the Ph.D. programs across nations and institutions offer only limited training in qualitative methods. In this opinion article, we draw upon our observations and experiences, unpacking and reflecting upon...... values and challenges at stake when qualitative studies are included in Ph.D. theses. Hypotheses to explain these observations are presented, followed by suggestions for standards of evaluation and improvement of Ph.D. programs. The authors conclude that multimethod Ph.D. theses should be encouraged...

  8. Postgraduate research training: the PhD and MD thesis.

    Science.gov (United States)

    Higginson, I; Corner, J

    1996-04-01

    Higher research degrees, such as the PhD, MPhil and MD, have existed within universities for 80 years or more, although the differences between the MD and PhD remain confused. A higher research degree training provides individuals with greater research knowledge and skills, and benefits the specialty. Concern exists about the levels of supervision sometimes provided, failure to complete degrees, and the variable levels of research knowledge and skills attained. We propose that higher research degrees in palliative care have four functions: extending personal scholarship, generating knowledge, training for the individual and contributing to the growth of the specialty. Such an approach may include: a formalised first year with taught components such as in research MSc programmes, formal supervision and progress assessment. In palliative care, clinical and academic approaches need greater integration. Multiprofessional learning is essential. To allow individuals to undertake higher research degree programmes, fellowships or specific funding are needed.

  9. Biomedical PhD education - an international perspective

    DEFF Research Database (Denmark)

    Mulvany, Michael J.

    2013-01-01

    tenured university positions. However, over the past 20–30 years, and particularly the past 10 years, the situation has changed dramatically. Governments in many countries have invested massively in PhD education, believing that trained researchers will contribute to the ‘knowledge society’, and thus...... during their PhD studies. The purpose of this article is to explore how this seeming paradox is being addressed in biomedicine and to show that far from being inconsistent that the two aspects are in fact complementary. The article is based on the author’s experience as Head of Aarhus Graduate School...... of Health Sciences 2002–2011 and his work with graduate schools across Europe and internationally through the organization ORPHEUS....

  10. Iterative Mixture Component Pruning Algorithm for Gaussian Mixture PHD Filter

    Directory of Open Access Journals (Sweden)

    Xiaoxi Yan

    2014-01-01

    Full Text Available As far as the increasing number of mixture components in the Gaussian mixture PHD filter is concerned, an iterative mixture component pruning algorithm is proposed. The pruning algorithm is based on maximizing the posterior probability density of the mixture weights. The entropy distribution of the mixture weights is adopted as the prior distribution of mixture component parameters. The iterative update formulations of the mixture weights are derived by Lagrange multiplier and Lambert W function. Mixture components, whose weights become negative during iterative procedure, are pruned by setting corresponding mixture weights to zeros. In addition, multiple mixture components with similar parameters describing the same PHD peak can be merged into one mixture component in the algorithm. Simulation results show that the proposed iterative mixture component pruning algorithm is superior to the typical pruning algorithm based on thresholds.

  11. Academic PHD School at Faculty of Agriculture in Tirana, Albania.

    Science.gov (United States)

    Bijo, B; Hoda, A; Thamaj, F

    2010-01-01

    Agricultural University of Tirana (AUT) is one of 12 public Universities in Albania. There are five Faculties within AUT. The study courses in AUT except of Faculty of Veterinary Medicine, are organized in three levels. Courses of the first level offer the fundamental knowledge. The students at the end of this cycle own 180 credits and obtain a first level diploma. In the second level study courses, the students get deeper theoretical and practical knowledge and modules are spread across 120 credits. At the end of this level the students obtain a second level diploma, according to the study course. In FVM, the study courses are organized as integrated program of second level that is spread across 300 credits. The students, who have finished the first level course, may go further in "Master of First level" for a professional training, where they do obtain 60 credits. The program of third cycle includes the courses of "Master of Second level" and the programs of PhD. The course of "Master of second level" is offered to the students who have achieved a Diploma of Second Level, and the students get deeper knowledge of scientific and professional character and do obtain at least 60 credits. PhD programs have totally an academic character. The principal aspect is the research and independent scientific activity. This program can be followed by the students who have a diploma of second level, or a diploma of "Master of Second level". The PhD program is organized in four years. The first year, consists of theoretical knowledge of the students. The second year is mainly research. The third year is research, data manipulation, publications, oral presentations and the last year is compilation of PhD thesis, its presentation and defense. Here is presented newly established doctoral school at Faculty of Agriculture and Environment.

  12. Lynn Sorbara, PhD | Division of Cancer Prevention

    Science.gov (United States)

    Dr. Lynn Sorbara earned her PhD from Albert Einstein College of Medicine in 1986. Her thesis research was in the areas of the mechanism of action of the drug, Taxol, and of multidrug resistance. After postdoctoral fellowships at the Rockefeller University and the Mount Sinai College of Medicine in Manhattan, she came to the NIH as a Senior Staff Fellow in the Diabetes Branch

  13. The PhD track: who succeeds, who drops out?

    OpenAIRE

    Groenvynck, Hans; Vandevelde, Karen; Van Rossem, Ronan

    2013-01-01

    Doctoral completion rates are an indicator of successful doctoral programmes and of a region's potential of highly skilled workforce. The Human Resources in Research - Flanders (HRRF) database contains data of all academic staff appointments, doctoral student registrations, and doctoral degrees of all Flemish universities from 1990 onwards. Previous research has identified the following factors as affecting successfully completing the PhD: cohort, scientific discipline, type of scholarship or...

  14. Researcher Profile: An Interview with Sarah Asebedo, Ph.D.

    OpenAIRE

    Martie Gillen

    2016-01-01

    Sarah Asebedo, Ph.D., CFP®, is an Assistant Professor of Personal Financial Planning with Texas Tech University. With extensive financial planning practitioner experience, her goal is to connect research and financial planning practice with a focus on the relationship between psychological attributes, financial conflicts, and financial behavior. Her work has been published in the Journal of Financial Planning, Journal of Financial Therapy, Journal of Financial Counselin...

  15. Curcumin Inhibits Growth of Human NCI-H292 Lung Squamous Cell Carcinoma Cells by Increasing FOXA2 Expression

    Directory of Open Access Journals (Sweden)

    Lingling Tang

    2018-02-01

    Full Text Available Lung squamous cell carcinoma (LSCC is a common histological lung cancer subtype, but unlike lung adenocarcinoma, limited therapeutic options are available for treatment. Curcumin, a natural compound, may have anticancer effects in various cancer cells, but how it may be used to treat LSCC has not been well studied. Here, we applied curcumin to a human NCI-H292 LSCC cell line to test anticancer effects and explored underlying potential mechanisms of action. Curcumin treatment inhibited NCI-H292 cell growth and increased FOXA2 expression in a time-dependent manner. FOXA2 expression was decreased in LSCC tissues compared with adjacent normal tissues and knockdown of FOXA2 increased NCI-H292 cells proliferation. Inhibition of cell proliferation by curcumin was attenuated by FOXA2 knockdown. Moreover inhibition of STAT3 pathways by curcumin increased FOXA2 expression in NCI-H292 cells whereas a STAT3 activator (IL-6 significantly inhibited curcumin-induced FOXA2 expression. Also, SOCS1 and SOCS3, negative regulators of STAT3 activity, were upregulated by curcumin treatment. Thus, curcumin inhibited human NCI-H292 cells growth by increasing FOXA2 expression via regulation of STAT3 signaling pathways.

  16. Quantification of Biodegradation: Applied Example on Oil Seeps in Armàncies Fm, Southeastern Pyrenees

    OpenAIRE

    Permanyer, Albert; Caja, Miguel Ángel

    2005-01-01

    La presencia de petróleo expulsado directamente de la roca madre de la Formación Armàncies, constituye un caso único para el estudio de los procesos de biodegradación aeróbica en petróleo. El estado de degradación bacteriana es moderado y está principalmente limitado a la alteración de n-alcanos, isoprenoides y algunos aromáticos. La cuantificación ha sido realizada mediante el contenido en sulfuro y con los marcadores moleculares de la fracción aromática. Los resultados obtenidos...

  17. Test de visualitat: les preferències del bon disseny

    Directory of Open Access Journals (Sweden)

    Quim Merino

    2014-07-01

    Full Text Available Aquest article pretén donar notícia de la investigació dirigida pel Grup de Recerca en Publicitat i Relacions Públiques (en endavant, GRP de la Universitat Autònoma de Barcelona duta a terme pels autors d'aquesta ressenya. El treball s'emmarca en una activitat de l'assignatura de Disseny en Publicitat i Relacions Públiques del Grau en Publicitat i Relacions Públiques de la UAB. L'objectiu del treball és constatar les preferències del consumidor davant diferents estímuls formals del disseny gràfic en publicitat

  18. Malalties de transmissió sexual a urgències pediàtriques

    OpenAIRE

    Díaz Sabogal, Diana; Curcoy Barcenilla, Ana Isabel; Trenchs Sainz de la Maza, Victoria; Giménez Roca, Clara; Luaces Cubells, Carles

    2014-01-01

    Determinar les característiques dels pacients diag- nosticats de malalties de transmissió sexual (MTS) a urgèn- cies i establir la freqüència en què són degudes a abús sexual. Mètode. Estudi retrospectiu fet entre el gener del 2007 i el desembre del 2011. S'inclouen els pacients menors de 18 anys diagnosticats a urgències d'MTS -infecció per Neisse- ria gonorrhoeae, Chlamydia trachomatis, Treponema palli- dum, , virus d'immunodeficiència humana (VIH), virus del pa- pil loma humà (VPH) i virus...

  19. Anàlisi forense d'evidències digitals

    OpenAIRE

    Bonachera López, Esteban

    2014-01-01

    L'objectiu principal d'aquest projecte consisteix en la realització de l'anàlisi forense del disc dur i de la memòria RAM d'un ordinador personal, en concret un Netbook, vinculat a una possible conducta delictiva. També s'inclou en l'anàlisi una base de dades del conegut programari WhatsApp extreta d'un smartphone. Per realitzar aquesta tasca s'utilitzaran eines específiques per localitzar les evidències digitals que puguin demostrar els presumptes delictes. El objetivo principal de este p...

  20. Phenethyl Isothiocyanate Induces Apoptotic Cell Death Through the Mitochondria-dependent Pathway in Gefitinib-resistant NCI-H460 Human Lung Cancer Cells In Vitro.

    Science.gov (United States)

    Hsia, Te-Chun; Huang, Yi-Ping; Jiang, Yi-Wen; Chen, Hsin-Yu; Cheng, Zheng-Yu; Hsiao, Yung-Ting; Chen, Cheng-Yen; Peng, Shu-Fen; Chueh, Fu-Shin; Chou, Yu-Cheng; Chung, Jing-Gung

    2018-04-01

    Some lung cancer patients treated with gefitinib develop resistance to this drug resulting in unsatisfactory treatment outcomes. Phenethyl isothiocyanate (PEITC), present in our common cruciferous vegetables, exhibits anticancer activities in many human cancer cell lines. Currently, there is no available information on the possible modification of gefitinib resistance of lung cancer in vitro by PEITC. Thus, the effects of PEITC on gefitinib resistant lung cancer NCI-H460 cells were investigated in vitro. The total cell viability, apoptotic cell death, production of reactive oxygen species (ROS) and Ca 2+ , levels of mitochondria membrane potential (ΔΨ m ) and caspase-3, -8 and -9 activities were measured by flow cytometry assay. PEITC induced chromatin condensation was examined by DAPI staining. PEITC-induced cell morphological changes, decreased total viable cell number and induced apoptotic cell death in NCI-H460 and NCI-H460/G cells. PEITC decreased ROS production in NCI-H460 cells, but increased production in NCI-H460/G cells. PEITC increased Ca 2+ production, decreased the levels of ΔΨ m and increased caspase-3, -8 and -9 activities in both NCI-H460 and NCI-H460/G cells. Western blotting was used to examine the effect of apoptotic cell death associated protein expression in NCI-H460 NCI-H460/G cells after exposure to PEITC. Results showed that PEITC increased expression of cleaved caspase-3, PARP, GADD153, Endo G and pro-apoptotic protein Bax in NCI-H460/G cells. Based on these results, we suggest that PEITC induces apoptotic cell death via the caspase- and mitochondria-dependent pathway in NCI-H460/G cells. Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  1. The national cancer institute (NCI) and cancer biology in a 'post genome world'

    International Nuclear Information System (INIS)

    Klausner, Richard D.

    1996-01-01

    The National Cancer Institute (NCI) exists to reduce the burden of all cancers through research and discovery. Extensive restructuring of the NCI over the past year has been aimed at assuring that the institution functions in all ways to promote opportunities for discovery in the laboratory, in the clinic, and in the community. To do this well requires the difficult and almost paradoxical problem of planning for scientific discovery which, in turn is based on the freedom to pursue the unanticipated. The intellectual and structural landscape of science is changing and it places new challenges, new demands and new opportunities for facilitating discovery. The nature of cancer as a disease of genomic instability and of accumulated genetic change, coupled with a possibility of the development of new technologies for reading, utilizing, interpreting and manipulating the genome of single cells, provides unprecedented opportunities for a new type of high through-put biology that will change the nature of discovery, cancer detection, diagnosis, prognosis, therapeutic decision-making and therapeutic discovery. To capture these new opportunities will require attention to be paid to integrate the development of technology and new scientific discoveries with the ability to apply advances rapidly and efficiently through clinical trials

  2. Enhanced Missing Proteins Detection in NCI60 Cell Lines Using an Integrative Search Engine Approach.

    Science.gov (United States)

    Guruceaga, Elizabeth; Garin-Muga, Alba; Prieto, Gorka; Bejarano, Bartolomé; Marcilla, Miguel; Marín-Vicente, Consuelo; Perez-Riverol, Yasset; Casal, J Ignacio; Vizcaíno, Juan Antonio; Corrales, Fernando J; Segura, Victor

    2017-12-01

    The Human Proteome Project (HPP) aims deciphering the complete map of the human proteome. In the past few years, significant efforts of the HPP teams have been dedicated to the experimental detection of the missing proteins, which lack reliable mass spectrometry evidence of their existence. In this endeavor, an in depth analysis of shotgun experiments might represent a valuable resource to select a biological matrix in design validation experiments. In this work, we used all the proteomic experiments from the NCI60 cell lines and applied an integrative approach based on the results obtained from Comet, Mascot, OMSSA, and X!Tandem. This workflow benefits from the complementarity of these search engines to increase the proteome coverage. Five missing proteins C-HPP guidelines compliant were identified, although further validation is needed. Moreover, 165 missing proteins were detected with only one unique peptide, and their functional analysis supported their participation in cellular pathways as was also proposed in other studies. Finally, we performed a combined analysis of the gene expression levels and the proteomic identifications from the common cell lines between the NCI60 and the CCLE project to suggest alternatives for further validation of missing protein observations.

  3. NCI Workshop Report: Clinical and Computational Requirements for Correlating Imaging Phenotypes with Genomics Signatures

    Directory of Open Access Journals (Sweden)

    Rivka Colen

    2014-10-01

    Full Text Available The National Cancer Institute (NCI Cancer Imaging Program organized two related workshops on June 26–27, 2013, entitled “Correlating Imaging Phenotypes with Genomics Signatures Research” and “Scalable Computational Resources as Required for Imaging-Genomics Decision Support Systems.” The first workshop focused on clinical and scientific requirements, exploring our knowledge of phenotypic characteristics of cancer biological properties to determine whether the field is sufficiently advanced to correlate with imaging phenotypes that underpin genomics and clinical outcomes, and exploring new scientific methods to extract phenotypic features from medical images and relate them to genomics analyses. The second workshop focused on computational methods that explore informatics and computational requirements to extract phenotypic features from medical images and relate them to genomics analyses and improve the accessibility and speed of dissemination of existing NIH resources. These workshops linked clinical and scientific requirements of currently known phenotypic and genotypic cancer biology characteristics with imaging phenotypes that underpin genomics and clinical outcomes. The group generated a set of recommendations to NCI leadership and the research community that encourage and support development of the emerging radiogenomics research field to address short-and longer-term goals in cancer research.

  4. THE NCI STUDIES ON RADIATION DOSES AND CANCER RISKS IN THE MARSHALL ISLANDS ASSOCIATED WITH EXPOSURE TO RADIOACTIVE FALLOUT

    OpenAIRE

    Simon, Steven L.

    2012-01-01

    The U.S. National Cancer Institute (NCI, National Institutes of Health) was requested by the U.S. Congress in 2004 to assess the number of radiation-related illnesses to be expected among the people of the Marshall Islands from nuclear tests conducted there during 1946-1958. A thorough analysis conducted by the NCI concluded that 20 of the 66 nuclear devices tested in or near the Marshall Islands resulted in measurable fallout deposition on one or more of the inhabited atolls of the Marshall ...

  5. Leonard F. Peltier, MD, PhD, 1920-2003.

    Science.gov (United States)

    Reckling, Frederick W; Lo Vecchio, Janolyn G; Reckling, JoAnn B

    2004-05-01

    Leonard F. Peltier, MD, PhD, was an orthopaedic surgeon, academician, administrator, laboratory investigator, historian, and mentor. His career spanned nearly six decades, beginning with graduate education at the University of Minnesota (UM) under the auspices of Owen H. Wangensteen, MD, PhD. In addition to obtaining a PhD in physiology in the UM Graduate School, he completed general and orthopaedic surgery residencies and attained board certification in each specialty. He served in the US Army Occupation Force Medical Corps in Germany just after World War II. In 1957, at 37 years old, he assumed the chairmanship of the orthopaedic training program at the University of Kansas. In 1971, he couldn't resist the opportunity to become one of the founding members of the "start-up" University of Arizona College of Medicine, accepting an appointment as chair of the new orthopaedic training program, where he remained until his retirement in 1990. He took clinical problems to the laboratory, and made important scientific contributions, particularly in the area of fat embolism and in using calcium sulfate (plaster of Paris) to fill bone defects. He served on governing boards of national professional organizations and presided over the American Association for the Surgery of Trauma from 1980-1981. Throughout his career, he was fascinated by, and published extensively in, the history of medicine arena. Known fondly as "the professor" to many of his residents and colleagues, he had a pragmatic, honest, upbeat, and often humorous approach to life's challenges, valuing personal integrity above other virtues. He explored various eclectic interests far beyond his professional contributions while maintaining his family as a central priority. With his exemplary productivity and interests in the surgical and laboratory sciences, history of medicine, appreciation of fine arts, and perceptive and effective interactions with family, friends, patients, and colleagues, the memory of Leonard

  6. MS PHD'S Professional Development Program: A Scientific Renaissance in Cyberspace

    Science.gov (United States)

    Powell, J. M.; Williamson, V. A.; Griess, C. A.; Pyrtle, A. J.

    2004-12-01

    This study is a component of a four-year investigation of MS PHD'S Professional Development Program's virtual community through the lenses of underrepresented minority students in Earth system science and engineering fields. In this presentation, the development, assessment and projected utilization of the ongoing study will be discussed. The overall goal of this study is to examine the effectiveness of virtual team building methods and understand how the development of a communal cyberinfrastructure acts as an integral part of the emergence of a Scientific Renaissance. The exemplar, Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S), provides professional development experiences to facilitate the advancement of students of color achieving outstanding Earth system careers. Undergraduate and graduate students are supported through access to scientific conferences, mentorship and virtual community building. Framed by critical theory, this ethnographic exploration uses a mixed methods research design to record, observe, and analyze both the processes and products of the website, listserv and synchronous web-based dialogue. First, key findings of the formative evaluation and annual reports of the successfully implemented 2003 MS PHD'S Pilot Project are presented. These findings inform future evaluations of the use of technological resources and illustrate how this public space provides peer support and enriched research opportunities. Quantitative methods such as statistical analysis, academic and professional tracking and evaluative tools for scientific content and competency are complimented by qualitative methods that include observations, heuristic case studies and focus group interviews. The findings of this ongoing investigation will provide insight on how national organizations, higher education practitioners, community-based support systems and underrepresented minorities in the sciences promote diversity by developing

  7. Financial Law (By: Lecturer PhD Cosmin Flavius Costas)

    OpenAIRE

    Bostan, Ionel

    2018-01-01

    Through these lines we will stop on a specialty written by a young university student, an exponent of the Superior Law School in Cluj-Napoca. This is the book entitled Drept Financiar [Financial Law], published by Lecturer PhD Cosmin Flavius Costas. On the volume entitled Financial Law, which was published at the end of the year 2016 (ISBN:978-606-673-816-3, Pages: 396) we mention here a radiography "made from four perspectives - national finances, local finance, social security finances and ...

  8. Mladen Zrinjski, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Tomislav Bašić

    2010-12-01

    Full Text Available Mladen Zrinjski defended his PhD thesis Defining the Calibration Baseline Scale of the Faculty of Geodesy by Applying Precise Electro-Optical Distance Meter and GPS at the Faculty of Geodesy of the University of Zagreb on April 8, 2010. The Defence Committee included Prof. Dr. Vedran Mudronja from the Faculty of Mechanical Engineering and Naval Architecture of the University of Zagreb, Prof. Dr. Tomislav Bašić (mentor 1 and Prof. Emeritus Nikola Solarić (mentor 2.

  9. Hrvoje Tomić, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Siniša Mastelić Ivić

    2010-12-01

    Full Text Available Hrvoje Tomić defended his PhD thesis Geospatial Data Analysis for the Purpose of Real Estate Valuation in Urban Areas at the Faculty of Geodesy, University of Zagreb, on November 15, 2010. His mentor was Prof. Dr. Siniša Mastelić Ivić, and the other two members of the Grading and Defence Committee were Assist. Prof. Dr. Vlado Cetl and Prof. Dr. Goran Poljanec from the Faculty of Civil Engineering, University of Zagreb.

  10. Communication and information-seeking behavior of PhD students in physicists and astronomy

    OpenAIRE

    Jamali, Hamid R.

    2006-01-01

    As a part of a wider doctoral research, this paper deals with the communication and information-seeking behavior of research (PhD) students in physics and astronomy. Based on a qualitative case study of PhD students in the Department of Physics and Astronomy at University College London, this study seeks to derive behavioral patterns in information-seeking activities of PhD students. The study aims to investigate the intradisciplinary differences in information-seeking activities of physicist...

  11. Plant collecting program in Southeast Asia under the sponsorship of the United States National Cancer Institute (NCI) (1986-1991)

    NARCIS (Netherlands)

    Soejarto, D.D.

    1992-01-01

    Under the funding from the United States National Cancer Institute (NCI)¹, a program was undertaken to collect plant samples in Southeast Asia to be tested for their cancer- and AIDS-arresting properties, for the period of September 1, 1986 through August 31, 1991. The program was implemented with

  12. NCI Helps Children’s Hospital of Philadelphia to Identify and Treat New Target in Pediatric Cancer | Poster

    Science.gov (United States)

    There may be a new, more effective method for treating high-risk neuroblastoma, according to scientists at the Children’s Hospital of Philadelphia and collaborators in the Cancer and Inflammation Program at NCI at Frederick. Together, the groups published a study describing a previously unrecognized protein on neuroblastoma cells, called GPC2, as well as the creation of a

  13. Photoactivatable Lipid-based Nanoparticles as a Vehicle for Dual Agent Delivery | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    Researchers at the National Cancer Institute (NCI) RNA Biology Laboratory have developed nanoparticles that can deliver an agent (i.e., therapeutic or imaging) and release the agent upon targeted photoactivation allowing for controlled temporal and localized release of the agent.

  14. Exploring PHD fingers and H3K4me0 interactions with molecular dynamics simulations and binding free energy calculations: AIRE-PHD1, a comparative study.

    Directory of Open Access Journals (Sweden)

    Dimitrios Spiliotopoulos

    Full Text Available PHD fingers represent one of the largest families of epigenetic readers capable of decoding post-translationally modified or unmodified histone H3 tails. Because of their direct involvement in human pathologies they are increasingly considered as a potential therapeutic target. Several PHD/histone-peptide structures have been determined, however relatively little information is available on their dynamics. Studies aiming to characterize the dynamic and energetic determinants driving histone peptide recognition by epigenetic readers would strongly benefit from computational studies. Herein we focus on the dynamic and energetic characterization of the PHD finger subclass specialized in the recognition of histone H3 peptides unmodified in position K4 (H3K4me0. As a case study we focused on the first PHD finger of autoimmune regulator protein (AIRE-PHD1 in complex with H3K4me0. PCA analysis of the covariance matrix of free AIRE-PHD1 highlights the presence of a "flapping" movement, which is blocked in an open conformation upon binding to H3K4me0. Moreover, binding free energy calculations obtained through Molecular Mechanics/Poisson-Boltzmann Surface Area (MM/PBSA methodology are in good qualitative agreement with experiments and allow dissection of the energetic terms associated with native and alanine mutants of AIRE-PHD1/H3K4me0 complexes. MM/PBSA calculations have also been applied to the energetic analysis of other PHD fingers recognizing H3K4me0. In this case we observe excellent correlation between computed and experimental binding free energies. Overall calculations show that H3K4me0 recognition by PHD fingers relies on compensation of the electrostatic and polar solvation energy terms and is stabilized by non-polar interactions.

  15. NCI's High Performance Computing (HPC) and High Performance Data (HPD) Computing Platform for Environmental and Earth System Data Science

    Science.gov (United States)

    Evans, Ben; Allen, Chris; Antony, Joseph; Bastrakova, Irina; Gohar, Kashif; Porter, David; Pugh, Tim; Santana, Fabiana; Smillie, Jon; Trenham, Claire; Wang, Jingbo; Wyborn, Lesley

    2015-04-01

    The National Computational Infrastructure (NCI) has established a powerful and flexible in-situ petascale computational environment to enable both high performance computing and Data-intensive Science across a wide spectrum of national environmental and earth science data collections - in particular climate, observational data and geoscientific assets. This paper examines 1) the computational environments that supports the modelling and data processing pipelines, 2) the analysis environments and methods to support data analysis, and 3) the progress so far to harmonise the underlying data collections for future interdisciplinary research across these large volume data collections. NCI has established 10+ PBytes of major national and international data collections from both the government and research sectors based on six themes: 1) weather, climate, and earth system science model simulations, 2) marine and earth observations, 3) geosciences, 4) terrestrial ecosystems, 5) water and hydrology, and 6) astronomy, social and biosciences. Collectively they span the lithosphere, crust, biosphere, hydrosphere, troposphere, and stratosphere. The data is largely sourced from NCI's partners (which include the custodians of many of the major Australian national-scale scientific collections), leading research communities, and collaborating overseas organisations. New infrastructures created at NCI mean the data collections are now accessible within an integrated High Performance Computing and Data (HPC-HPD) environment - a 1.2 PFlop supercomputer (Raijin), a HPC class 3000 core OpenStack cloud system and several highly connected large-scale high-bandwidth Lustre filesystems. The hardware was designed at inception to ensure that it would allow the layered software environment to flexibly accommodate the advancement of future data science. New approaches to software technology and data models have also had to be developed to enable access to these large and exponentially

  16. ANIONIC POLYMERIZATION OF ALKYL METHACRYLATES INITIATED BY nBuCu(NCy2)Li

    Institute of Scientific and Technical Information of China (English)

    Bing-yong Han; Jian-guo Liang; Jian-min Lu; Feng An; Wan-tai Yang

    2009-01-01

    Anionic polymerization of methyl methacrylate (MMA), n-butyl methacrylate (nBMA) and glycidyl methacrylate (GMA) initiated by nBuCu(NCy2)Li (1) in tetrahydrofuran (THF) at -50℃ to -10℃ was investigated. It was found that the polymerization of MMA and nBMA initiated by 1 proceeded quantitatively in THF to afford PMMA and PBMA with polydispersity index 1.15-1.30 and nearly 100% initiator efficiencies at -10℃. The molecular weights increased linearly with the ratio of [monomer]/[1]. However, a post-polymerization experiment carried out on this system revealed a double polymer peak by GPC when fresh monomer was added after an interval of 10 rain. Polymerization of styrene could be initiated by 1, but the initiator efficiency was low.

  17. Pharmacokinetics and Safety of Bortezomib in Patients with Advanced Malignancies and Varying Degrees of Liver Dysfunction: Phase 1 NCI Organ Dysfunction Working Group Study NCI-6432

    Science.gov (United States)

    LoRusso, Patricia M; Venkatakrishnan, Karthik; Ramanathan, Ramesh K; Sarantopoulos, John; Mulkerin, Daniel; Shibata, Stephen I; Hamilton, Anne; Dowlati, Afshin; Mani, Sridhar; Rudek, Michelle A; Takimoto, Chris H; Neuwirth, Rachel; Esseltine, Dixie-Lee; Ivy, Percy

    2013-01-01

    Purpose The proteasome inhibitor bortezomib undergoes oxidative hepatic metabolism. This study (NCI-6432; NCT00091117) was conducted to evaluate bortezomib pharmacokinetics and safety in patients with varying degrees of hepatic impairment, to inform dosing recommendations in these special populations. Methods Patients received bortezomib on days 1, 4, 8, and 11 of 21-day cycles. Patients were assigned to four hepatic function groups based on the National Cancer Institute Organ Dysfunction Working Group classification. Those with normal function received bortezomib at the 1.3 mg/m2 standard dose. Patients with severe, moderate, and mild impairment received escalating doses from 0.5, 0.7, and 1.0 mg/m2, respectively, up to a 1.3 mg/m2 maximum. Serial blood samples were collected for 24 hours post-dose on days 1 and 8, cycle 1, for bortezomib plasma concentration measurements. Results Sixty-one patients were treated, including 14 with normal hepatic function and 17, 12, and 18 with mild, moderate, and severe impairment, respectively. Mild hepatic impairment did not alter dose-normalized bortezomib exposure (AUC0-tlast) or Cmax compared with patients with normal function. Mean dose-normalized AUC0-tlast was increased by approximately 60% on day 8 in patients with moderate or severe impairment. Conclusions Patients with mild hepatic impairment do not require a starting dose adjustment of bortezomib. Patients with moderate or severe hepatic impairment should be started at a reduced dose of 0.7 mg/m2. PMID:22394984

  18. Direct cortical hemodynamic mapping of somatotopy of pig nostril sensation by functional near-infrared cortical imaging (fNCI).

    Science.gov (United States)

    Uga, Minako; Saito, Toshiyuki; Sano, Toshifumi; Yokota, Hidenori; Oguro, Keiji; Rizki, Edmi Edison; Mizutani, Tsutomu; Katura, Takusige; Dan, Ippeita; Watanabe, Eiju

    2014-05-01

    Functional near-infrared spectroscopy (fNIRS) is a neuroimaging technique for the noninvasive monitoring of human brain activation states utilizing the coupling between neural activity and regional cerebral hemodynamics. Illuminators and detectors, together constituting optodes, are placed on the scalp, but due to the presence of head tissues, an inter-optode distance of more than 2.5cm is necessary to detect cortical signals. Although direct cortical monitoring with fNIRS has been pursued, a high-resolution visualization of hemodynamic changes associated with sensory, motor and cognitive neural responses directly from the cortical surface has yet to be realized. To acquire robust information on the hemodynamics of the cortex, devoid of signal complications in transcranial measurement, we devised a functional near-infrared cortical imaging (fNCI) technique. Here we demonstrate the first direct functional measurement of temporal and spatial patterns of cortical hemodynamics using the fNCI technique. For fNCI, inter-optode distance was set at 5mm, and light leakage from illuminators was prevented by a special optode holder made of a light-shielding rubber sheet. fNCI successfully detected the somatotopy of pig nostril sensation, as assessed in comparison with concurrent and sequential somatosensory-evoked potential (SEP) measurements on the same stimulation sites. Accordingly, the fNCI system realized a direct cortical hemodynamic measurement with a spatial resolution comparable to that of SEP mapping on the rostral region of the pig brain. This study provides an important initial step toward realizing functional cortical hemodynamic monitoring during neurosurgery of human brains. Copyright © 2014. Published by Elsevier Inc.

  19. Investigation of internalization and cytotoxicity of 125I-[Tyr3]-octreotide in NCI-H446 cell line

    International Nuclear Information System (INIS)

    Sun Junjie; Fan Wo; Xu Yujie; Zhang Youjiu; Zhu Ran; Hu Mingjiang

    2004-01-01

    Objective: To investigate the [Tyr 3 ]-octreotide (TOC) internalizing capacity of NCI-H446 cell line, and the cytotoxicity of 125 I-TOC in NCI-H446 cell line. To assess the therapeutic radiopharmaceutical potentiality of 125 I-TOC for the somatostatin receptor (SSTR) positive tumor. Methods: NCI-H446 cells were incubated together with 125 I-TOC for different periods of time, the amount of internalized 125 I-TOC and the 125 I-TOC bound on the cellular nucleus were detected with γ counter, respectively. The viability of the cells was analyzed by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay at different time points with various doses of 125 I-TOC, free 125 I and TOC. Results: 125 I-TOC was internalized into the nucleus and bound on the nucleus in a time-dependent manner. 125 I-TOC bound on the nucleus increased to the highest level at 24 h, the amount of nucleus bound 125 I-TOC at 24 h was 7 times higher than that at 0.5 h. Cytotoxicity of 125 I-TOC in SSTR positive NCI-H446 cells was also dose- and time-dependent. The supreme effect of cytotoxicity was found at 96 h with 74 kBq 125 I-TOC, the survival ratio of cells was reduced to (44.8 ± 7.2)%. Conclusions: 125 I-TOC can be internalized into SSTR positive cells mediated by SSTR. The NCI-H446 cells can be killed by Auger electron emitting from 125 I-TOC. Effect of cytotoxicity showed dose- and time-dependent

  20. NCI's national environmental research data collection: metadata management built on standards and preparing for the semantic web

    Science.gov (United States)

    Wang, Jingbo; Bastrakova, Irina; Evans, Ben; Gohar, Kashif; Santana, Fabiana; Wyborn, Lesley

    2015-04-01

    National Computational Infrastructure (NCI) manages national environmental research data collections (10+ PB) as part of its specialized high performance data node of the Research Data Storage Infrastructure (RDSI) program. We manage 40+ data collections using NCI's Data Management Plan (DMP), which is compatible with the ISO 19100 metadata standards. We utilize ISO standards to make sure our metadata is transferable and interoperable for sharing and harvesting. The DMP is used along with metadata from the data itself, to create a hierarchy of data collection, dataset and time series catalogues that is then exposed through GeoNetwork for standard discoverability. This hierarchy catalogues are linked using a parent-child relationship. The hierarchical infrastructure of our GeoNetwork catalogues system aims to address both discoverability and in-house administrative use-cases. At NCI, we are currently improving the metadata interoperability in our catalogue by linking with standardized community vocabulary services. These emerging vocabulary services are being established to help harmonise data from different national and international scientific communities. One such vocabulary service is currently being established by the Australian National Data Services (ANDS). Data citation is another important aspect of the NCI data infrastructure, which allows tracking of data usage and infrastructure investment, encourage data sharing, and increasing trust in research that is reliant on these data collections. We incorporate the standard vocabularies into the data citation metadata so that the data citation become machine readable and semantically friendly for web-search purpose as well. By standardizing our metadata structure across our entire data corpus, we are laying the foundation to enable the application of appropriate semantic mechanisms to enhance discovery and analysis of NCI's national environmental research data information. We expect that this will further

  1. Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S) Beyond the PhD Professional Development Program: A Pilot Project

    Science.gov (United States)

    Johnson, A.; Jearld, A.; Williamson Whitney, V.; Huggans, M.; Ricciardi, L.; Thomas, S. H.; Jansma, P. E.

    2012-12-01

    In 2011 the Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S)® initiative launched its newest activity entitled the MS PHD'S "Beyond the PhD (B-PhD) Professional Development Program." This exciting new program was designed to facilitate the development of a new community of underrepresented minority (URM) doctoral candidates and recent doctorate degree recipients in Earth system science (ESS)-related fields. The MS PHD'S B-PhD provides customized support and advocacy for MS PHD'S B-PhD participants in order to facilitate smoother and informed transitions from graduate school, to postdoctoral and tenure-track positions, as well as other "first" jobs in government, industry, and non-profit organizations. In November 2011 the first cohort of MS PHD'S B-PhD participants engaged in intensive sessions on the following topics: "Toolkits for Success for Academia, Business/Industry, Federal Government and Non-Profits", "Defining Short, Mid and Long Term Career Goals", "Accessing and Refining Skill Sets and Other Door Openers", "International Preparation and Opportunities", "Paying it Forward/Lifting as You Climb", and "Customized Strategies for Next Steps". This pilot event, which was hosted by the University of Texas at Arlington's (UTA) College of Science, also provided opportunities for participants to serve as guest lecturers in the UTA's Colleges of Science and Engineering and included one-on-one discussions with MS PHD'S B-PhD mentors and guest speakers who are well established within their individual ESS fields. Insights regarding opportunities, challenges and obstacles commonly faced by URMs within the ESS fields, as well as strategies for success were shared by MS PHD'S B-PhD mentors and guest speakers. Survey results indicate that MS PHD'S B-PhD participants appreciated not only the material covered during this pilot activity, but also appreciated the opportunity to become part of a community of young URM ESS

  2. Mentored peer reviewing for PhD faculty and students.

    Science.gov (United States)

    Xu, Jiayun; Kim, Kyounghae; Kurtz, Melissa; Nolan, Marie T

    2016-02-01

    There is a need for scholars to be prepared as peer reviewers in order to ensure the continual publication of quality science. However, developing the skills to craft a constructive critique can be difficult. In this commentary, we discuss the use of a group peer review mentoring model for PhD students to gain experience in peer review from a faculty member who is experienced in peer review. Central to this model, was the opportunity for each student and faculty mentor to openly discuss their critique of the manuscript. Through this enriching experience, novice researchers were able to learn the elements of a good peer review, better determine a manuscript's substantive contribution to science, and advance the quality of their own manuscript writing. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. PhD Thesis: Functional Textiles in Hospital Interiors

    DEFF Research Database (Denmark)

    Mogensen, Jeppe Emil

    The PhD thesis explores the possibilities and design qualities of using functional textiles in the interior of hospital environments, and is the result of a three-year collaboration between Aalborg University, Department of Civil Engineering, and VIA University College, VIA Design. The thesis...... years, knowledge on the use of interior materials and textiles are still rather limited. Contemporary hospital design has been widely criticised of being too institutional and clinical, and one of the main reasons for this experience may be related to the use of ‘cold’, hard-surfaced materials...... of plastic, vinyl and steel. These materials also dominate the new hospitals, designed and constructed these years, and despite the increased focus on the design concept healing architecture, the rational requirements of ef cient cleaning and maintenance still seems to direct the interior design of hospital...

  4. Denis Radoš, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Damir Magaš

    2017-12-01

    Full Text Available Denis Radoš, MSc in Geography, and assistant and junior researcher at the Chair for Cartography and Geographic Information Systems (GIS at the Department of Geography of the University of Zadar, has successfully defended his PhD thesis entitled Topography Analysis in the Wind Estimation Process within the doctoral studies in The Adriatic – A Link Between Continents organized by the Department of History and the Department of Geography of the University of Zadar. The thesis was defended in the Rectorate of the University of Zadar before a commission comprising Assoc. Prof. Dr. Sanja Lozić, chairperson, Full Professor with tenure Dr. Damir Magaš, mentor, and Assist. Prof. Dr. Mladen Pahernik.

  5. Researcher Profile: An Interview with Jodi Letkiewicz, Ph.D.

    Directory of Open Access Journals (Sweden)

    Jodi Letkiewicz

    2014-12-01

    Full Text Available Jodi Letkiewicz, Ph.D., is an assistant professor of finance at York University in Toronto, Ontario. She teaches in the Certified Financial Planner® Core Curriculum program preparing undergraduate students for the Canadian CFP® certification and conducts research in several areas of personal finance and consumer decision-making, including behavioral aspects influencing the decision to seek financial help, how personality traits affect financial decision-making, and the financial state of young adults, including the impact student loans have on overall well-being and financial milestones early in their adult life. Dr. Letkiewicz’s goal is to increase financial well-being in the general public, which she hopes to accomplish through teaching, research, and community outreach.

  6. Attitude of PhD Students Towards Academic Dishonesty

    Directory of Open Access Journals (Sweden)

    Vilija Grincevičienė

    2011-04-01

    Full Text Available The article describes the problem of academic dishonesty. Looking over the results of research done in foreign countries (the USA, Romania, Poland, it is possible to assert that the ethics of a scientist is a topical problem nowadays not only in Lithuania but also all over the world. The results of pilot research show that although in all curricula, textbooks and other sources it is declared that each researcher or a team must keep to certain ethics rules, not everything goes well. Respondents were first year PhD students of Vilnius Gediminas Technical University (N=51. Taking into account the results, more attention should be paid to the analysis and correction of the situation.

  7. Earth and Space Science PhD Employment Trends

    Science.gov (United States)

    Giesler, J. L.

    2001-05-01

    A recent report by the American Geophysical Union and the American Geological Institute, "Earth and Space Science PhDs, Class of 1999" looked at employment trends of recent graduates. Demographically, our graduates are, as a population, older than those who graduated in any other physical science. While almost one-third of graduates are employed in a different subfield than that of their degree, more than 80% of Earth and space science PhDs secure initial employment in the geosciences. Graduates are finding employment in less than 6 months and the unemployment rate has dropped significantly below that of two years ago. The PhD classes of 1996, 1997, and 1998 had ~ 50% of their graduates taking postdoctoral appointments. In 1999, this declined to only 38% postdocs with an increase in permanent employment in both the education and government sectors. Perception of the job market is improving as well. Respondents are considerably happier than they were in 1996.

  8. Analysis list: ph-d [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ph-d Cell line,Embryo + dm3 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/p...h-d.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/ph-d.5.tsv http://dbarchive.biosciencedbc.jp.../kyushu-u/dm3/target/ph-d.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/ph-d.Cell_line.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/ph-d.Embryo.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/Cell_line.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Embryo.gml ...

  9. Learning from a Lived Experience of a PhD: A Reflexive Ethnography of Two Journeys

    Science.gov (United States)

    Aziato, Lydia

    2015-01-01

    Introduction: Nurses globally have strived to obtain a Doctor of Philosophy Degree (PhD) especially those in academia. Few publications have focused on lived experiences of nurses especially those reporting failed attempts. Thus, this paper presents how lessons learnt from a failed attempt of a PhD in Nursing was used to achieve an outstanding…

  10. Pipelines or pipe dreams? PhD production and other matters in a ...

    African Journals Online (AJOL)

    This retrospective study documents the Masters and PhD training of 131 Dental Research Institute (DRI) postgraduates (1954-2006) to establish demographics, throughput and research outcomes for future PhD pipeline strategies using the DRI database. Descriptive statistics show four degree-based groups of ...

  11. A networked pathway to the PhD: The African-Norwegian case of ...

    African Journals Online (AJOL)

    How do PhD students become socialised into the professional world of academic work? This article pays attention to a 'networked' support pathway towards a PhD. The network constitutes an international research collaboration through a programme called Productive Learning Cultures (PLC) (2002-2011) between Norway ...

  12. Searching for "A Third Space": A Creative Pathway towards International PhD Students' Academic Acculturation

    Science.gov (United States)

    Elliot, Dely Lazarte; Baumfield, Vivienne; Reid, Kate

    2016-01-01

    Undertaking a PhD is a challenging endeavour. Pursuing a doctoral education in a "foreign" context tends to increase the demands of this intellectual venture. The nature of research-based PhD programmes, often characterised by a lack of formal curricula where academic supervision lasts several years, may add another layer of complexity.…

  13. A model perception on the independence of PhD students in ...

    African Journals Online (AJOL)

    Amy Stambach

    A model perception on the independence of PhD students in promoting the ... At school of postgraduate studies, all academic documents related to PhD ..... Workshop series sponsored by the counseling center at the University of Illinois in ...

  14. A fast ellipse extended target PHD filter using box-particle implementation

    Science.gov (United States)

    Zhang, Yongquan; Ji, Hongbing; Hu, Qi

    2018-01-01

    This paper presents a box-particle implementation of the ellipse extended target probability hypothesis density (ET-PHD) filter, called the ellipse extended target box particle PHD (EET-BP-PHD) filter, where the extended targets are described as a Poisson model developed by Gilholm et al. and the term "box" is here equivalent to the term "interval" used in interval analysis. The proposed EET-BP-PHD filter is capable of dynamically tracking multiple ellipse extended targets and estimating the target states and the number of targets, in the presence of clutter measurements, false alarms and missed detections. To derive the PHD recursion of the EET-BP-PHD filter, a suitable measurement likelihood is defined for a given partitioning cell, and the main implementation steps are presented along with the necessary box approximations and manipulations. The limitations and capabilities of the proposed EET-BP-PHD filter are illustrated by simulation examples. The simulation results show that a box-particle implementation of the ET-PHD filter can avoid the high number of particles and reduce computational burden, compared to a particle implementation of that for extended target tracking.

  15. NASA Graduate Student Researchers Program Ronald E. McNair PhD Program

    Science.gov (United States)

    Howard, Sunnie

    1998-01-01

    The NASA Ronald E. McNair PHD Program was funded in September 1995. Implementation began during the spring of 1996. The deferment of the actual program initial semester enabled the program to continue support through the fall semester of 1998. This was accomplished by a no-cost extension from August 15, 1998 through December 31, 1998. There were 12 fellows supported by the program in 1996, 15 fellows in 1997, and 15 fellows 1998. Current program capacity is 15 fellows per funding support. Support for the academic outreach component began in spring 1998. The program was named the "Good Enough" Crew Activity (GECA) in honor of Dr. McNair's philosophy of everyone being good enough to achieve anything they want bad enough. The program currently enrolls 65 students from the third through the eight grades. The program is held 12 Saturdays per semester. The time is 9:00 AM to 12:30 PM each Saturday Morning. Program direction and facilitation is jointly administered with the PHD fellows and the Saturday Academy staff. Dr. John Kelly, REM-PHD Principal Investigator serves in a program oversight and leadership capacity. Ms. Sunnie Howard, The NASA REM-PHD Administrative Coordinator serves in an administrative and logistical capacity. Mr. Aaron Hatch, the NASA-AMES Liaison Officer, serve@'in a consultative and curriculum review capacity. The first recognition activity will be held on December 12, 1998, with the students, parents, faculty, PHD fellows, and other local student support services persons. Program outreach efforts are jointly supported by the NASA REM-PHD Program and the National Space Grant College and Fellowship Program. The Ph.D. program reached its first milestone in May 1998. North Carolina A&T State University graduated the first Ph.D. fellows. The first three Ph.D. Alumni were Ronald E. McNair PHD Program Fellows. It is hoped that this is just the beginning of a highly acclaimed doctoral program. The ultimate program success will be recognized when the

  16. Qualitative methods in PhD theses from general practice in Scandinavia.

    Science.gov (United States)

    Malterud, Kirsti; Hamberg, Katarina; Reventlow, Susanne

    2017-12-01

    Qualitative methodology is gaining increasing attention and esteem in medical research, with general practice research taking a lead. With these methods, human and social interaction and meaning can be explored and shared by systematic interpretation of text from talk, observation or video. Qualitative studies are often included in Ph.D. theses from general practice in Scandinavia. Still, the Ph.D. programs across nations and institutions offer only limited training in qualitative methods. In this opinion article, we draw upon our observations and experiences, unpacking and reflecting upon values and challenges at stake when qualitative studies are included in Ph.D. theses. Hypotheses to explain these observations are presented, followed by suggestions for standards of evaluation and improvement of Ph.D. programs. The authors conclude that multimethod Ph.D. theses should be encouraged in general practice research, in order to offer future researchers an appropriate toolbox.

  17. MATLAB simulation software used for the PhD thesis "Acquisition of Multi-Band Signals via Compressed Sensing

    DEFF Research Database (Denmark)

    2014-01-01

    MATLAB simulation software used for the PhD thesis "Acquisition of Multi-Band Signals via Compressed Sensing......MATLAB simulation software used for the PhD thesis "Acquisition of Multi-Band Signals via Compressed Sensing...

  18. Metformin synergistically enhances antiproliferative effects of cisplatin and etoposide in NCI-H460 human lung cancer cells

    Directory of Open Access Journals (Sweden)

    Sarah Fernandes Teixeira

    2013-12-01

    Full Text Available OBJECTIVE: To test the effectiveness of combining conventional antineoplastic drugs (cisplatin and etoposide with metformin in the treatment of non-small cell lung cancer in the NCI-H460 cell line, in order to develop new therapeutic options with high efficacy and low toxicity.METHODS: We used the 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT assay and calculated the combination index for the drugs studied.RESULTS: We found that the use of metformin as monotherapy reduced the metabolic viability of the cell line studied. Combining metformin with cisplatin or etoposide produced a synergistic effect and was more effective than was the use of cisplatin or etoposide as monotherapy.CONCLUSIONS: Metformin, due to its independent effects on liver kinase B1, had antiproliferative effects on the NCI-H460 cell line. When metformin was combined with cisplatin or etoposide, the cell death rate was even higher.

  19. NCI Releases Video: Proteogenomics Research - On the Frontier of Precision Medicine | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The Clinical Proteomic Tumor Analysis Consortium (CPTAC) of the National Cancer Institute (NCI), part of the National Institutes of Health, announces the release of an educational video titled “Proteogenomics Research: On the Frontier of Precision Medicine."  Launched at the HUPO2017 Global Leadership Gala Dinner, catalyzed in part by the Cancer Moonshot initiative and featuring as keynote speaker the 47th Vice President of the United States of America Joseph R.

  20. An ensemble based top performing approach for NCI-DREAM drug sensitivity prediction challenge.

    Directory of Open Access Journals (Sweden)

    Qian Wan

    Full Text Available We consider the problem of predicting sensitivity of cancer cell lines to new drugs based on supervised learning on genomic profiles. The genetic and epigenetic characterization of a cell line provides observations on various aspects of regulation including DNA copy number variations, gene expression, DNA methylation and protein abundance. To extract relevant information from the various data types, we applied a random forest based approach to generate sensitivity predictions from each type of data and combined the predictions in a linear regression model to generate the final drug sensitivity prediction. Our approach when applied to the NCI-DREAM drug sensitivity prediction challenge was a top performer among 47 teams and produced high accuracy predictions. Our results show that the incorporation of multiple genomic characterizations lowered the mean and variance of the estimated bootstrap prediction error. We also applied our approach to the Cancer Cell Line Encyclopedia database for sensitivity prediction and the ability to extract the top targets of an anti-cancer drug. The results illustrate the effectiveness of our approach in predicting drug sensitivity from heterogeneous genomic datasets.

  1. In memoriam: an appreciation for the NCI R25T cancer education and career development program.

    Science.gov (United States)

    Chang, Shine

    2014-06-01

    On September 7, 2013, the NCI R25T award mechanism ended its final "receipt/review/award cycle" after more than two decades shaping the cancer prevention and control workforce. Created in 1991 to respond to a national shortage of cancer prevention and control researchers, the R25T supported innovative institutional programs with specialized curricula preparing individuals for careers as independent scientists for the field. Required elements ensured developing transdisciplinary sensibilities and skills highly suited to team science, including conducting collaborative research with mentors of complementary expertise. R25Ts provided trainee stipends, research, education, and travel funds at levels far higher than T32 National Service Research Awards to attract individuals from diverse disciplines. Graduates are faculty at all academic ranks, and hold leadership positions such as associate directors of cancer prevention and control. Beyond its trainees, R25Ts also recruited into the field other students exposed through courses in specialized prevention curricula, as well as course instructors and trainee mentors, who did not initially consider their work to be relevant to cancer prevention. Although advances are being achieved, prevention efforts are not yet fully realized, and currently unknown is the impact on the workforce of terminating the R25T, including whether it is another barrier to preventing cancer. ©2014 American Association for Cancer Research.

  2. NCI Think Tank Concerning the Identifiability of Biospecimens and “-Omic” Data

    Science.gov (United States)

    Weil, Carol J.; Mechanic, Leah E.; Green, Tiffany; Kinsinger, Christopher; Lockhart, Nicole C.; Nelson, Stefanie A.; Rodriguez, Laura L.; Buccini, Laura D.

    2014-01-01

    On June 11 and 12, 2012, the National Cancer Institute (NCI) hosted a think tank concerning the identifiability of biospecimens and “omic” Data in order to explore challenges surrounding this complex and multifaceted topic. The think tank brought together forty-six leaders from several fields, including cancer genomics, bioinformatics, human subject protection, patient advocacy, and commercial genetics. The first day involved presentations regarding the state of the science of re-identification; current and proposed regulatory frameworks for assessing identifiability; developments in law, industry and biotechnology; and the expectations of patients and research participants. The second day was spent by think tank participants in small break-out groups designed to address specific sub-topics under the umbrella issue of identifiability, including considerations for the development of best practices for data sharing and consent, and targeted opportunities for further empirical research. We describe the outcomes of this two day meeting, including two complimentary themes that emerged from moderated discussions following the presentations on Day 1, and ideas presented for further empirical research to discern the preferences and concerns of research participants about data sharing and individual identifiability. PMID:23579437

  3. Permissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68

    International Nuclear Information System (INIS)

    Ascierto, Maria Libera; Bedognetti, Davide; Uccellini, Lorenzo; Rossano, Fabio; Ascierto, Paolo A; Stroncek, David F; Restifo, Nicholas P; Wang, Ena; Szalay, Aladar A; Marincola, Francesco M; Worschech, Andrea; Yu, Zhiya; Adams, Sharon; Reinboth, Jennifer; Chen, Nanhai G; Pos, Zoltan; Roychoudhuri, Rahul; Di Pasquale, Giovanni

    2011-01-01

    Oncolytic viral therapy represents an alternative therapeutic strategy for the treatment of cancer. We previously described GLV-1h68, a modified Vaccinia Virus with exclusive tropism for tumor cells, and we observed a cell line-specific relationship between the ability of GLV-1h68 to replicate in vitro and its ability to colonize and eliminate tumor in vivo. In the current study we surveyed the in vitro permissivity to GLV-1h68 replication of the NCI-60 panel of cell lines. Selected cell lines were also tested for permissivity to another Vaccinia Virus and a vesicular stomatitis virus (VSV) strain. In order to identify correlates of permissity to viral infection, we measured transcriptional profiles of the cell lines prior infection. We observed highly heterogeneous permissivity to VACV infection amongst the cell lines. The heterogeneity of permissivity was independent of tissue with the exception of B cell derivation. Cell lines were also tested for permissivity to another Vaccinia Virus and a vesicular stomatitis virus (VSV) strain and a significant correlation was found suggesting a common permissive phenotype. While no clear transcriptional pattern could be identified as predictor of permissivity to infection, some associations were observed suggesting multifactorial basis permissivity to viral infection. Our findings have implications for the design of oncolytic therapies for cancer and offer insights into the nature of permissivity of tumor cells to viral infection

  4. Developing Cancer Informatics Applications and Tools Using the NCI Genomic Data Commons API.

    Science.gov (United States)

    Wilson, Shane; Fitzsimons, Michael; Ferguson, Martin; Heath, Allison; Jensen, Mark; Miller, Josh; Murphy, Mark W; Porter, James; Sahni, Himanso; Staudt, Louis; Tang, Yajing; Wang, Zhining; Yu, Christine; Zhang, Junjun; Ferretti, Vincent; Grossman, Robert L

    2017-11-01

    The NCI Genomic Data Commons (GDC) was launched in 2016 and makes available over 4 petabytes (PB) of cancer genomic and associated clinical data to the research community. This dataset continues to grow and currently includes over 14,500 patients. The GDC is an example of a biomedical data commons, which collocates biomedical data with storage and computing infrastructure and commonly used web services, software applications, and tools to create a secure, interoperable, and extensible resource for researchers. The GDC is (i) a data repository for downloading data that have been submitted to it, and also a system that (ii) applies a common set of bioinformatics pipelines to submitted data; (iii) reanalyzes existing data when new pipelines are developed; and (iv) allows users to build their own applications and systems that interoperate with the GDC using the GDC Application Programming Interface (API). We describe the GDC API and how it has been used both by the GDC itself and by third parties. Cancer Res; 77(21); e15-18. ©2017 AACR . ©2017 American Association for Cancer Research.

  5. NCI Funding Trends and Priorities in Physical Activity and Energy Balance Research Among Cancer Survivors.

    Science.gov (United States)

    Alfano, Catherine M; Bluethmann, Shirley M; Tesauro, Gina; Perna, Frank; Agurs-Collins, Tanya; Elena, Joanne W; Ross, Sharon A; O'Connell, Mary; Bowles, Heather R; Greenberg, Deborah; Nebeling, Linda

    2016-01-01

    There is considerable evidence that a healthy lifestyle consisting of physical activity, healthy diet, and weight control is associated with reduced risk of morbidity and mortality after cancer. However, these behavioral interventions are not widely adopted in practice or community settings. Integrating heath behavior change interventions into standard survivorship care for the growing number of cancer survivors requires an understanding of the current state of the science and a coordinated scientific agenda for the future with focused attention in several priority areas. To facilitate this goal, this paper presents trends over the past decade of the National Cancer Institute (NCI) research portfolio, fiscal year 2004 to 2014, by funding mechanism, research focus, research design and methodology, primary study exposures and outcomes, and study team expertise and composition. These data inform a prioritized research agenda for the next decade focused on demonstrating value and feasibility and creating desire for health behavior change interventions at multiple levels including the survivor, clinician, and healthcare payer to facilitate the development and implementation of appropriately targeted, adaptive, effective, and sustainable programs for all survivors. Published by Oxford University Press (2015). This work is written by (a) US Government employee(s) and is in the public domain in the US.

  6. Detecting Role Errors in the Gene Hierarchy of the NCI Thesaurus

    Directory of Open Access Journals (Sweden)

    Yehoshua Perl

    2008-01-01

    Full Text Available Gene terminologies are playing an increasingly important role in the ever-growing field of genomic research. While errors in large, complex terminologies are inevitable, gene terminologies are even more susceptible to them due to the rapid growth of genomic knowledge and the nature of its discovery. It is therefore very important to establish quality- assurance protocols for such genomic-knowledge repositories. Different kinds of terminologies oftentimes require auditing methodologies adapted to their particular structures. In light of this, an auditing methodology tailored to the characteristics of the NCI Thesaurus’s (NCIT’s Gene hierarchy is presented. The Gene hierarchy is of particular interest to the NCIT’s designers due to the primary role of genomics in current cancer research. This multiphase methodology focuses on detecting role-errors, such as missing roles or roles with incorrect or incomplete target structures, occurring within that hierarchy. The methodology is based on two kinds of abstraction networks, called taxonomies, that highlight the role distribution among concepts within the IS-A (subsumption hierarchy. These abstract views tend to highlight portions of the hierarchy having a higher concentration of errors. The errors found during an application of the methodology

  7. Highlights of recent developments and trends in cancer nanotechnology research--view from NCI Alliance for Nanotechnology in Cancer.

    Science.gov (United States)

    Hull, L C; Farrell, D; Grodzinski, P

    2014-01-01

    Although the incidence of cancer and cancer related deaths in the United States has decreased over the past two decades due to improvements in early detection and treatment, cancer still is responsible for a quarter of the deaths in this country. There is much room for improvement on the standard treatments currently available and the National Cancer Institute (NCI) has recognized the potential for nanotechnology and nanomaterials in this area. The NCI Alliance for Nanotechnology in Cancer was formed in 2004 to support multidisciplinary researchers in the application of nanotechnology to cancer diagnosis and treatment. The researchers in the Alliance have been productive in generating innovative solutions to some of the central issues of cancer treatment including how to detect tumors earlier, how to target cancer cells specifically, and how to improve the therapeutic index of existing chemotherapies and radiotherapy treatments. Highly creative ideas are being pursued where novelty in nanomaterial development enables new modalities of detection or therapy. This review highlights some of the innovative materials approaches being pursued by researchers funded by the NCI Alliance. Their discoveries to improve the functionality of nanoparticles for medical applications includes the generation of new platforms, improvements in the manufacturing of nanoparticles and determining the underlying reasons for the movement of nanoparticles in the blood. © 2013.

  8. Integrative research on environmental and landscape change: PhD students' motivations and challenges.

    Science.gov (United States)

    Tress, Bärbel; Tress, Gunther; Fry, Gary

    2009-07-01

    The growing demand for integrative (interdisciplinary or transdisciplinary) approaches in the field of environmental and landscape change has increased the number of PhD students working in this area. Yet, the motivations to join integrative projects and the challenges for PhD students have so far not been investigated. The aims of this paper were to identify the understanding of PhD students with regard to integrative research, their motivations to join integrative projects, their expectations in terms of integration and results, and to reveal the challenges they face in integrative projects. We collected data by a questionnaire survey of 104 PhD students attending five PhD Master Classes held from 2003 to 2006. We used manual content analysis to analyse the free-text answers. The results revealed that students lack a differentiated understanding of integrative approaches. The main motivations to join integrative projects were the dissertation subject, the practical relevance of the project, the intellectual stimulation of working with different disciplines, and the belief that integrative research is more innovative. Expectations in terms of integration were high. Core challenges for integration included intellectual and external challenges such as lack of knowledge of other disciplines, knowledge transfer, reaching depth, supervision, lack of exchange with other students and time demands. To improve the situation for PhD students, we suggest improving knowledge on integrative approaches, balancing practical applicability with theoretical advancement, providing formal introductions to other fields of research, and enhancing institutional support for integrative PhD projects.

  9. Partnership for development: A peer mentorship model for PhD students.

    Science.gov (United States)

    Lewinski, Allison A; Mann, Tara; Flores, Dalmacio; Vance, Ashlee; Bettger, Janet Prvu; Hirschey, Rachel

    Formal mentoring relationships socialize Doctor of Philosophy (PhD) students to their current and future roles as nursing scholars. Despite formal mentoring, some students may desire or benefit from additional mentoring in an informal setting. Informal mentoring complements the one-to-one relationship students develop with a primary faculty mentor or dissertation chair. This manuscript describes the development, implementation, and evaluation of a student-driven, peer mentorship model, titled Partnership for Development. This small group, peer mentorship model was implemented in a PhD program at a School of Nursing during an academic year. Five student peer facilitators organized a total of 32 PhD students, 2 post-doctoral associates, and invited 5 faculty to participate. Data includes pre- and post-implementation surveys completed by the students and peer facilitator field notes. Student reported post-participation benefits included: getting to know faculty in an informal setting (n=6), socializing with students from other cohorts (n=6), and obtaining a sense of camaraderie with other PhD students (n=5). We recommend peer mentorship for other PhD programs as a way to socialize PhD students into the role of nurse scientist and assist students during their tenure as a PhD student. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. Les competències. La doctrina del Tribunal sobre la definició de les competències. Les competències exclusives, les compartides i les executives. - Las competencias. La doctrina del Tribunal sobre la definición de las competencias. Competencias exclusivas, compartidas y ejecutivas.

    Directory of Open Access Journals (Sweden)

    Ramon Riu

    2010-07-01

    Full Text Available La doctrina de la Sentència 31/2010 sobre la definició estatutària de les categories competencials (251-257 Mercè Barceló i SerramaleraLa doctrina del Tribunal Constitucional sobre la definició de competències. Les competències exclusives, les compartides i les executives (258-261Antoni Bayona RocamoraLa doctrina de la Sentència 31/2010 sobre les competències executives (Xavier Bernadí GilLa doctrina del Tribunal sobre la definició de les competències. Les ompetències exclusives, les compartides i les executives (270-276Marc Carrillo LópezEls efectes de la Sentència sobre la definició estatutària de les competències: la «devaluació» jurídica dels estatuts d’autonomia (277-281Mercè Corretja TorrensLes categories funcionals de competències a l’Estatut d’autonomia de Catalunya. Comentaris a la Sentència 31/2010 (282-287Ramon Riu FortunyTipologia de les competències. El seu abast funcional: els articles 110 a 112 (288-294Joaquín Tornos Massostenella e no enmendalla (262-269 La doctrina de la Sentencia 31/2010 sobre la definición estatutaria de las categorías competenciales (251-257Mercè Barceló i SerramaleraLa doctrina del Tribunal Constitucional sobre la definición de competencias. Las competencias exclusivas, las compartidas y las ejecutivas (258-261Antoni Bayona RocamoraLa doctrina de la Sentencia 31/2010 sobre las competencias ejecutivas (sostenella e no enmendalla (262-270 Xavier Bernadí GilLa doctrina del Tribunal sobre la definición de las competencias. Las competencias exclusivas, las compartidas y las ejecutivas (271-277Marc Carrillo LópezLos efectos de la Sentencia sobre la definición estatutaria de las competencias:la «devaluación» jurídica de los estatutos de autonomía (278-283Mercè Corretja TorrensLas categorías funcionales de competencias en el Estatuto de Autonomía de Cataluña. Comentarios a la Sentencia 31/2010 (284-289Ramon Riu FortunyTipología de las competencias. Su alcance

  11. Ann O'Mara, PhD, RN, MPH | Division of Cancer Prevention

    Science.gov (United States)

    Dr. Ann O'Mara is Head of Palliative Research in the NCI Division of Cancer Prevention. She manages a portfolio of symptom management and palliative and end-of-life care research projects. The majority of these projects focus on the more common morbidities associated with cancer and its treatment, e.g., pain, chemotherapy induced neuropathy, fatigue, sleep disturbances, and

  12. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger.

    Science.gov (United States)

    Wang, Gang G; Song, Jikui; Wang, Zhanxin; Dormann, Holger L; Casadio, Fabio; Li, Haitao; Luo, Jun-Li; Patel, Dinshaw J; Allis, C David

    2009-06-11

    Histone H3 lysine 4 methylation (H3K4me) has been proposed as a critical component in regulating gene expression, epigenetic states, and cellular identities1. The biological meaning of H3K4me is interpreted by conserved modules including plant homeodomain (PHD) fingers that recognize varied H3K4me states. The dysregulation of PHD fingers has been implicated in several human diseases, including cancers and immune or neurological disorders. Here we report that fusing an H3K4-trimethylation (H3K4me3)-binding PHD finger, such as the carboxy-terminal PHD finger of PHF23 or JARID1A (also known as KDM5A or RBBP2), to a common fusion partner nucleoporin-98 (NUP98) as identified in human leukaemias, generated potent oncoproteins that arrested haematopoietic differentiation and induced acute myeloid leukaemia in murine models. In these processes, a PHD finger that specifically recognizes H3K4me3/2 marks was essential for leukaemogenesis. Mutations in PHD fingers that abrogated H3K4me3 binding also abolished leukaemic transformation. NUP98-PHD fusion prevented the differentiation-associated removal of H3K4me3 at many loci encoding lineage-specific transcription factors (Hox(s), Gata3, Meis1, Eya1 and Pbx1), and enforced their active gene transcription in murine haematopoietic stem/progenitor cells. Mechanistically, NUP98-PHD fusions act as 'chromatin boundary factors', dominating over polycomb-mediated gene silencing to 'lock' developmentally critical loci into an active chromatin state (H3K4me3 with induced histone acetylation), a state that defined leukaemia stem cells. Collectively, our studies represent, to our knowledge, the first report that deregulation of the PHD finger, an 'effector' of specific histone modification, perturbs the epigenetic dynamics on developmentally critical loci, catastrophizes cellular fate decision-making, and even causes oncogenesis during mammalian development.

  13. Strategy formulation for the Phd Health Market (Pty) Ltd franchise group / Henk Heath

    OpenAIRE

    Heath, Henk

    2007-01-01

    Phd Health Market (Pty) Ltd was born from the vision of Anton Dupper and Advocate Jan Grobler, to turn a health store in Welkom, South Africa, into a national health franchise in the health & fitness industry. Phd Health Market has a vision to radically change society as a whole by changing nutritional eating and instilling a healthy lifestyle as a whole, which could be easily adapted by all. Phd Health Market is a small developing franchise group, requiring a much needed strategic plan in or...

  14. Doc of prophage P1 is inhibited by its antitoxin partner Phd through fold complementation

    DEFF Research Database (Denmark)

    Garcia-Pino, Abel; Christensen-Dalsgaard, Mikkel; Wyns, Lode

    2008-01-01

    Prokaryotic toxin-antitoxin modules are involved in major physiological events set in motion under stress conditions. The toxin Doc (death on curing) from the phd/doc module on phage P1 hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation....... This Phd domain is intrinsically disordered in solution and folds into an alpha-helix upon binding to Doc. The details of the interactions reveal the molecular basis for the inhibitory action of the antitoxin. The complex resembles the Fic (filamentation induced by cAMP) proteins and suggests a possible......-antitoxin locus for its action in vivo....

  15. Personal profile: interview with Bill Andrews, Ph.D.

    Science.gov (United States)

    Andrews, Bill

    2011-08-01

    Dr. William H. Andrews has worked in the biotech industry for 31 years, focusing the last 19 years on finding ways to extend human life span through the intervention of telomere shortening in human cells. Dr. Andrews earned his Ph.D. in Molecular and Population Genetics at the University of Georgia. He was a Senior Scientist at Armos Corporation and Codon Corporation, Director of Molecular Biology at Codon and at Geron Corporation, and Director of Technology Development at EOS Biosciences. He is presently the founder, President, and CEO of Sierra Sciences, a biotechnology company focused exclusively on finding drugs that will transiently induce the expression of endogenous telomerase in human cells. Sierra Sciences has already identified more than 30 such drugs and is presently characterizing their mechanism of action. While Director of Molecular Biology at Geron Corporation, Dr. Andrews was one of the principal discoverers of both the RNA and protein components of human telomerase and was awarded second place as "National Inventor of the Year" in 1997 for this work. He is presently a named inventor on 43 U.S- issued telomerase patents.

  16. The Intrinsically Disordered Domain of the Antitoxin Phd Chaperones the Toxin Doc against Irreversible Inactivation and Misfolding*

    Science.gov (United States)

    De Gieter, Steven; Konijnenberg, Albert; Talavera, Ariel; Butterer, Annika; Haesaerts, Sarah; De Greve, Henri; Sobott, Frank; Loris, Remy; Garcia-Pino, Abel

    2014-01-01

    The toxin Doc from the phd/doc toxin-antitoxin module targets the cellular translation machinery and is inhibited by its antitoxin partner Phd. Here we show that Phd also functions as a chaperone, keeping Doc in an active, correctly folded conformation. In the absence of Phd, Doc exists in a relatively expanded state that is prone to dimerization through domain swapping with its active site loop acting as hinge region. The domain-swapped dimer is not capable of arresting protein synthesis in vitro, whereas the Doc monomer is. Upon binding to Phd, Doc becomes more compact and is secured in its monomeric state with a neutralized active site. PMID:25326388

  17. Improving global data infrastructures for more effective and scalable analysis of Earth and environmental data: the Australian NCI NERDIP Approach

    Science.gov (United States)

    Evans, Ben; Wyborn, Lesley; Druken, Kelsey; Richards, Clare; Trenham, Claire; Wang, Jingbo; Rozas Larraondo, Pablo; Steer, Adam; Smillie, Jon

    2017-04-01

    The National Computational Infrastructure (NCI) facility hosts one of Australia's largest repositories (10+ PBytes) of research data collections spanning datasets from climate, coasts, oceans, and geophysics through to astronomy, bioinformatics, and the social sciences domains. The data are obtained from national and international sources, spanning a wide range of gridded and ungridded (i.e., line surveys, point clouds) data, and raster imagery, as well as diverse coordinate reference projections and resolutions. Rather than managing these data assets as a digital library, whereby users can discover and download files to personal servers (similar to borrowing 'books' from a 'library'), NCI has built an extensive and well-integrated research data platform, the National Environmental Research Data Interoperability Platform (NERDIP, http://nci.org.au/data-collections/nerdip/). The NERDIP architecture enables programmatic access to data via standards-compliant services for high performance data analysis, and provides a flexible cloud-based environment to facilitate the next generation of transdisciplinary scientific research across all data domains. To improve use of modern scalable data infrastructures that are focused on efficient data analysis, the data organisation needs to be carefully managed including performance evaluations of projections and coordinate systems, data encoding standards and formats. A complication is that we have often found multiple domain vocabularies and ontologies are associated with equivalent datasets. It is not practical for individual dataset managers to determine which standards are best to apply to their dataset as this could impact accessibility and interoperability. Instead, they need to work with data custodians across interrelated communities and, in partnership with the data repository, the international scientific community to determine the most useful approach. For the data repository, this approach is essential to enable

  18. UK to train 100 PhD students in data science

    Science.gov (United States)

    Allen, Michael

    2017-12-01

    A new PhD programme to develop techniques to handle the vast amounts of data being generated by experiments and facilities has been launched by the UK's Science and Technology Facilities Council (STFC).

  19. Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach.

    Science.gov (United States)

    Amato, Anastasia; Lucas, Xavier; Bortoluzzi, Alessio; Wright, David; Ciulli, Alessio

    2018-04-20

    Plant homeodomain (PHD) zinc fingers are histone reader domains that are often associated with human diseases. Despite this, they constitute a poorly targeted class of readers, suggesting low ligandability. Here, we describe a successful fragment-based campaign targeting PHD fingers from the proteins BAZ2A and BAZ2B as model systems. We validated a pool of in silico fragments both biophysically and structurally and solved the first crystal structures of PHD zinc fingers in complex with fragments bound to an anchoring pocket at the histone binding site. The best-validated hits were found to displace a histone H3 tail peptide in competition assays. This work identifies new chemical scaffolds that provide suitable starting points for future ligand optimization using structure-guided approaches. The demonstrated ligandability of the PHD reader domains could pave the way for the development of chemical probes to drug this family of epigenetic readers.

  20. Trends in landscape research and landscape planning : implications for PhD students

    NARCIS (Netherlands)

    Tress, G.; Tress, B.; Fry, G.; Antrop, M.

    2005-01-01

    This chapter introduces the contents of the book through an analysis of current trends in landscape research and landscape planning and a discussion of the consequences of these trends for PhD students.

  1. WHAT ARE AGRICULTURAL ECONOMICS PH.D. STUDENTS LEARNING ABOUT AGRIBUSINESS RESEARCH METHODS AND SUBJECT AREAS?

    OpenAIRE

    House, Lisa; Sterns, James A.

    2002-01-01

    This document contains the PowerPoint presentation given by the authors at the 2002 WCC-72 meetings, regarding what agricultural economics Ph.D students are learning about agribusiness research methods and subject areas.

  2. Announcing the 2016 Toxins Travel Awards for Post-Doctoral Fellows and Ph.D. Students

    OpenAIRE

    Tesh, Vernon L.

    2016-01-01

    With the goal of promoting the development of early career investigators in the field of toxinology, Toxins welcomed applications for the 2016 Toxins Travel Awards for post-doctoral fellows and Ph.D. students. [...

  3. Announcing the 2016 Toxins Travel Awards for Post-Doctoral Fellows and Ph.D. Students

    Directory of Open Access Journals (Sweden)

    Vernon L. Tesh

    2016-02-01

    Full Text Available With the goal of promoting the development of early career investigators in the field of toxinology, Toxins welcomed applications for the 2016 Toxins Travel Awards for post-doctoral fellows and Ph.D. students. [...

  4. Actualization of the PhD Students' Intercultural Research Competencies in Global Society

    Directory of Open Access Journals (Sweden)

    Inga Dailidiene

    2013-12-01

    Full Text Available globalization is changing the qualitative characteristics of society, affecting both the life and mentality of people. In relevance to globalization, higher education is gaining new dimensions as well. Bologna and Lisbon documents guide and obligate each country to create integrated and harmonious international space of higher education in Europe. phd studies are considered as integral in the higher education structure; therefore, internationalization is a significant imperative for phd studies development. In the process of internationalization, the need for students’ intercultural competencies is widely recognized. Firstly, we suppose that the impact of globalization on internationalization still remains underestimated. Globalization makes internationalization not only more intense, but also qualitatively different. Secondly, there is a lack of systemic analysis on the development of intercultural research competencies in phd studies. We relate the need for intercultural research competencies to the following critical and rhetorical question: ‘Are today’s phd students ready to solve tomorrow’s global problems?’

  5. Ph.D. Post-Doctoral Training Program in Breast Cancer Research

    National Research Council Canada - National Science Library

    Edwards, Dean

    2002-01-01

    .... The curriculum of the Breast Cancer Training Program extends beyond that of the normal Ph.D. requirements to include didactic classroom teaching, journal clubs, seminars, workshops and mini-symposiums on relevant topics in breast cancer...

  6. Ph.D. Post-Doctoral Training Program in Breast Cancer Research

    National Research Council Canada - National Science Library

    Edwards, Dean

    2001-01-01

    .... The curriculum of the Breast Cancer Training Program extends beyond that of the normal Ph.D. requirements to include didactic classroom teaching, journal clubs, seminars, workshops and mini-symposiums on relevant topics in breast cancer...

  7. Ph.D. Post-Doctoral Training Program in Breast Cancer Research

    National Research Council Canada - National Science Library

    Edwards, Dean

    2004-01-01

    .... The curriculum of the Breast Cancer Training Program extends beyond that of the normal Ph.D. requirements to include didactic classroom teaching, journal clubs, seminars, workshops and mini-symposiums on relevant topics in breast cancer...

  8. CPT Special Report: Survey of Ph.D. Programs in Chemistry.

    Science.gov (United States)

    Journal of Chemical Education, 1997

    1997-01-01

    Presents preliminary results from a survey taken by the American Chemical Society (ACS) Committee on Professional Training (CPT) to determine the current practices among 155 Ph.D. programs in chemistry. (DKM)

  9. Readability of Online Patient Educational Resources Found on NCI-Designated Cancer Center Web Sites.

    Science.gov (United States)

    Rosenberg, Stephen A; Francis, David; Hullett, Craig R; Morris, Zachary S; Fisher, Michael M; Brower, Jeffrey V; Bradley, Kristin A; Anderson, Bethany M; Bassetti, Michael F; Kimple, Randall J

    2016-06-01

    The NIH and Department of Health & Human Services recommend online patient information (OPI) be written at a sixth grade level. We used a panel of readability analyses to assess OPI from NCI-Designated Cancer Center (NCIDCC) Web sites. Cancer.gov was used to identify 68 NCIDCC Web sites from which we collected both general OPI and OPI specific to breast, prostate, lung, and colon cancers. This text was analyzed by 10 commonly used readability tests: the New Dale-Chall Readability Formula, Flesch Reading Ease scale, Flesch-Kinaid Grade Level, FORCAST scale, Fry Readability Graph, Simple Measure of Gobbledygook test, Gunning Frequency of Gobbledygook index, New Fog Count, Raygor Readability Estimate Graph, and Coleman-Liau Index. We tested the hypothesis that the readability of NCIDCC OPI was written at the sixth grade level. Secondary analyses were performed to compare readability of OPI between comprehensive and noncomprehensive centers, by region, and to OPI produced by the American Cancer Society (ACS). A mean of 30,507 words from 40 comprehensive and 18 noncomprehensive NCIDCCs was analyzed (7 nonclinical and 3 without appropriate OPI were excluded). Using a composite grade level score, the mean readability score of 12.46 (ie, college level: 95% CI, 12.13-12.79) was significantly greater than the target grade level of 6 (middle-school: Preadability metrics (P<.05). ACS OPI provides easier language, at the seventh to ninth grade level, across all tests (P<.01). OPI from NCIDCC Web sites is more complex than recommended for the average patient. Copyright © 2016 by the National Comprehensive Cancer Network.

  10. Articulating Expectations for PhD Candidature upon Commencement: Ensuring Supervisor/Student "Best Fit"

    Science.gov (United States)

    Moxham, Lorna; Dwyer, Trudy; Reid-Searl, Kerry

    2013-01-01

    The journey towards completion of a PhD is a bumpy one for many. One of the major factors that influence successful and on-time thesis completion is the relationship that the PhD candidate has with her or his supervisor. This paper presents results from research undertaken using a 12-item survey to collect data from a purposive sample: PhD…

  11. Social Policy in Social Work PhD Programs in the United States

    Science.gov (United States)

    Lightfoot, Elizabeth; Gal, John; Weiss-Gal, Idit

    2018-01-01

    While there has been a long-standing concern about the role of policy within social work education and social work practice, most of the emphasis has been on social work education at the BSW and MSW levels. This article examines policy education at the PhD level. It first explores how policy is taught in social work PhD programs in the United…

  12. MS PHD'S: Effective Strategies for the Retention and Advancement of URM Students in ESS

    Science.gov (United States)

    Escalera, J.; Burgess, A. K.; Pace, L.; Scott, O.; Strickland, J.; Johnson, A.; Williamson Whitney, V.; Ithier-Guzman, W.

    2012-12-01

    The Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S) Professional Development Program in Earth system science (ESS) is a model initiative for improving the retention of underrepresented minority (URM) students in STEM fields. Entering its ninth cohort, MS PHD'S remains committed to helping URM undergraduate and graduate students achieve outstanding careers in ESS. MS PHD'S facilitates URM student achievement through a three-phase program designed to increase student exposure to the ESS community. By engaging in a series of professional development and skill building exercises, peer-to-peer community building activities, participation in scientific society conferences and workshops, mentoring by URM and other scientists, and a virtual community, URM students gain the confidence and support necessary to achieve their academic goals and enter the ESS workforce. Since its inception, MS PHD'S continues to support 189 participants. Of these 189 participants, 35 have advanced from undergraduate and graduate academic pathways to completion of their PhD and another 60 are currently enrolled in doctoral programs. MS PHD'S maintains close ties with program alumni to further support retention, inclusivity, and broadening participation of URM students and graduates in STEM activities. Its model is built on reengaging alumni to become mentors and leaders for each new cohort as well as facilitating valuable opportunities for alumni to advance in their ESS related academic and professional career pathways.

  13. Skill development in collaborative research projects: A comparison between PhD students in multi-actor research programs and in traditional trajectories

    NARCIS (Netherlands)

    Wardenaar, T.; Belder, R.; de Goede, M.E.E; Horlings, E.; van den Besselaar, P.

    2014-01-01

    The growing number of PhD students has spurred debates about the societal relevance of PhD training trajectories. The academic labour market does not provide enough jobs and many PhD graduates will have a career outside academia. It has been questioned whether current PhD training trajectories are

  14. Preparing for Graduate-Level Training in Professional Psychology: Comparisons across Clinical PhD, Counseling PhD, and Clinical PsyD Programs

    Science.gov (United States)

    Karazsia, Bryan T.; Smith, Lena

    2016-01-01

    In the present study, faculty who teach in clinical and counseling doctor of philosophy (PhD) or doctor of psychology (PsyD) programs completed surveys regarding preferences for prospective student preparations to graduate programs. Faculty expectations of minimum and ideal undergraduate training were highest for scientific methods, though…

  15. Computational Environments and Analysis methods available on the NCI High Performance Computing (HPC) and High Performance Data (HPD) Platform

    Science.gov (United States)

    Evans, B. J. K.; Foster, C.; Minchin, S. A.; Pugh, T.; Lewis, A.; Wyborn, L. A.; Evans, B. J.; Uhlherr, A.

    2014-12-01

    The National Computational Infrastructure (NCI) has established a powerful in-situ computational environment to enable both high performance computing and data-intensive science across a wide spectrum of national environmental data collections - in particular climate, observational data and geoscientific assets. This paper examines 1) the computational environments that supports the modelling and data processing pipelines, 2) the analysis environments and methods to support data analysis, and 3) the progress in addressing harmonisation of the underlying data collections for future transdisciplinary research that enable accurate climate projections. NCI makes available 10+ PB major data collections from both the government and research sectors based on six themes: 1) weather, climate, and earth system science model simulations, 2) marine and earth observations, 3) geosciences, 4) terrestrial ecosystems, 5) water and hydrology, and 6) astronomy, social and biosciences. Collectively they span the lithosphere, crust, biosphere, hydrosphere, troposphere, and stratosphere. The data is largely sourced from NCI's partners (which include the custodians of many of the national scientific records), major research communities, and collaborating overseas organisations. The data is accessible within an integrated HPC-HPD environment - a 1.2 PFlop supercomputer (Raijin), a HPC class 3000 core OpenStack cloud system and several highly connected large scale and high-bandwidth Lustre filesystems. This computational environment supports a catalogue of integrated reusable software and workflows from earth system and ecosystem modelling, weather research, satellite and other observed data processing and analysis. To enable transdisciplinary research on this scale, data needs to be harmonised so that researchers can readily apply techniques and software across the corpus of data available and not be constrained to work within artificial disciplinary boundaries. Future challenges will

  16. Vectors to Increase Production Efficiency of Inducible Pluripotent Stem Cell (iPSC) | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    This invention describes the discovery that specific p53 isoform increase the number of inducible pluripotent stem cells (iPS). It is known that the activity of p53 regulates the self-renewal and pluripotency of normal and cancer stem cells, and also affects re-programming efficiency of iPS cells. This p53 isoform-based technology provides a more natural process of increasing iPS cell production than previous methods of decreasing p53. NCI seeks licensees for this technology.

  17. NCI-60 whole exome sequencing and pharmacological CellMiner analyses.

    Directory of Open Access Journals (Sweden)

    William C Reinhold

    Full Text Available Exome sequencing provides unprecedented insights into cancer biology and pharmacological response. Here we assess these two parameters for the NCI-60, which is among the richest genomic and pharmacological publicly available cancer cell line databases. Homozygous genetic variants that putatively affect protein function were identified in 1,199 genes (approximately 6% of all genes. Variants that are either enriched or depleted compared to non-cancerous genomes, and thus may be influential in cancer progression and differential drug response were identified for 2,546 genes. Potential gene knockouts are made available. Assessment of cell line response to 19,940 compounds, including 110 FDA-approved drugs, reveals ≈80-fold range in resistance versus sensitivity response across cell lines. 103,422 gene variants were significantly correlated with at least one compound (at p<0.0002. These include genes of known pharmacological importance such as IGF1R, BRAF, RAD52, MTOR, STAT2 and TSC2 as well as a large number of candidate genes such as NOM1, TLL2, and XDH. We introduce two new web-based CellMiner applications that enable exploration of variant-to-compound relationships for a broad range of researchers, especially those without bioinformatics support. The first tool, "Genetic variant versus drug visualization", provides a visualization of significant correlations between drug activity-gene variant combinations. Examples are given for the known vemurafenib-BRAF, and novel ifosfamide-RAD52 pairings. The second, "Genetic variant summation" allows an assessment of cumulative genetic variations for up to 150 combined genes together; and is designed to identify the variant burden for molecular pathways or functional grouping of genes. An example of its use is provided for the EGFR-ERBB2 pathway gene variant data and the identification of correlated EGFR, ERBB2, MTOR, BRAF, MEK and ERK inhibitors. The new tools are implemented as an updated web-based Cell

  18. Tendències en el disseny metodològic de recerca sobre l’avaluació de competències a l’educació superior

    Directory of Open Access Journals (Sweden)

    Karina Angélica Villegas Sandoval

    2017-01-01

    Full Text Available L’article té com a finalitat descriure i analitzar les metodologies d'investigació utilitzades per estudis recents que aborden el tema de l’avaluació per competències a l’educació superior i la formació docent, per tal de detectar les tendències en el disseny metodològic i orientar futurs projectes d'investigació sobre aquest tema. El mètode de treball que s'ha seguit per dur a terme aquest estudi és l’anàlisi de contingut de 22 documents trobats a Dialnet. Els resultats mostren que les investigacions que tracten el tema assenyalat han anat en augment en els últims tretze anys, i es destaca el canvi de metodologia utilitzada, amb dissenys majoritàriament descriptius i avaluatius. Al seu torn, però, crida l'atenció que un gran nombre d'estudis no expliquen ni el mètode ni el disseny d'investigació que han aplicat. Es conclou que és important que les investigacions presentin un apartat que al·ludeixi al disseny metodològic a fi d’afavorir la comprensió del lector dels processos d'indagació que s'han dut a terme.

  19. DELETION OR INHIBITION OF THE OXYGEN SENSOR PHD1 PROTECTS AGAINST ISCHEMIC STROKE VIA REPROGRAMMING OF NEURONAL METABOLISM

    Science.gov (United States)

    Quaegebeur, Annelies; Segura, Inmaculada; Schmieder, Roberta; Verdegem, Dries; Decimo, Ilaria; Bifari, Francesco; Dresselaers, Tom; Eelen, Guy; Ghosh, Debapriva; Schoors, Sandra; Janaki Raman, Sudha Rani; Cruys, Bert; Govaerts, Kristof; De Legher, Carla; Bouché, Ann; Schoonjans, Luc; Ramer, Matt S.; Hung, Gene; Bossaert, Goele; Cleveland, Don W.; Himmelreich, Uwe; Voets, Thomas; Lemmens, Robin; Bennett, C. Frank; Robberecht, Wim; De Bock, Katrien; Dewerchin, Mieke; Fendt, Sarah-Maria; Ghesquière, Bart; Carmeliet, Peter

    2016-01-01

    Summary The oxygen-sensing prolyl hydroxylase domain proteins (PHDs) regulate cellular metabolism, but their role in neuronal metabolism during stroke is unknown. Here we report that PHD1 deficiency provides neuroprotection in a murine model of permanent brain ischemia. This was not due to an increased collateral vessel network, nor to enhanced neurotrophin expression. Instead, PHD1−/− neurons were protected against oxygen-nutrient deprivation by reprogramming glucose metabolism. Indeed, PHD1−/− neurons enhanced glucose flux through the oxidative pentose phosphate pathway by diverting glucose from glycolysis. As a result, PHD1−/− neurons increased their redox buffering capacity to scavenge oxygen radicals in ischemia. Intracerebroventricular injection of PHD1-antisense oligonucleotides reduced the cerebral infarct size and neurological deficits following stroke. These data identify PHD1 as a novel regulator of neuronal metabolism and a potential therapeutic target in ischemic stroke. PMID:26774962

  20. Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism.

    Science.gov (United States)

    Quaegebeur, Annelies; Segura, Inmaculada; Schmieder, Roberta; Verdegem, Dries; Decimo, Ilaria; Bifari, Francesco; Dresselaers, Tom; Eelen, Guy; Ghosh, Debapriva; Davidson, Shawn M; Schoors, Sandra; Broekaert, Dorien; Cruys, Bert; Govaerts, Kristof; De Legher, Carla; Bouché, Ann; Schoonjans, Luc; Ramer, Matt S; Hung, Gene; Bossaert, Goele; Cleveland, Don W; Himmelreich, Uwe; Voets, Thomas; Lemmens, Robin; Bennett, C Frank; Robberecht, Wim; De Bock, Katrien; Dewerchin, Mieke; Ghesquière, Bart; Fendt, Sarah-Maria; Carmeliet, Peter

    2016-02-09

    The oxygen-sensing prolyl hydroxylase domain proteins (PHDs) regulate cellular metabolism, but their role in neuronal metabolism during stroke is unknown. Here we report that PHD1 deficiency provides neuroprotection in a murine model of permanent brain ischemia. This was not due to an increased collateral vessel network. Instead, PHD1(-/-) neurons were protected against oxygen-nutrient deprivation by reprogramming glucose metabolism. Indeed, PHD1(-/-) neurons enhanced glucose flux through the oxidative pentose phosphate pathway by diverting glucose away from glycolysis. As a result, PHD1(-/-) neurons increased their redox buffering capacity to scavenge oxygen radicals in ischemia. Intracerebroventricular injection of PHD1-antisense oligonucleotides reduced the cerebral infarct size and neurological deficits following stroke. These data identify PHD1 as a regulator of neuronal metabolism and a potential therapeutic target in ischemic stroke. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. Plummer-Vinson Syndrome with Improvement After Iron Repletion ...

    African Journals Online (AJOL)

    The patient presented with long-standing dysphagia and symptomatic anemia. Gastrointestinal endoscopy revealed an upper esophageal web arising from the anterior wall. She was started on iron therapy daily and after 2 months both the dysphagia and anemia had improved significantly. Therefore, though this is a ...

  2. Avaluació de competències professionalitzadores en els estudis de grau de comunicació audiovisual

    Directory of Open Access Journals (Sweden)

    Marina Romeo

    2017-01-01

    Full Text Available Els recents canvis en la formació universitària han comportat un destacable nivell de professionalització dels estudis i una constant adequació a les demandes socials. En aquest sentit, una de les necessitats per a la formació universitària a l'àrea de la comunicació audiovisual és desenvolupar en els estudiants competències professionalitzadores que els permetin trobar nínxols d'ocupació en un mercat altament competitiu i sotmès a canvis continus. Aquesta recerca té per objecte crear una rúbrica que permeti avaluar l'aprenentatge professionalitzador en els estudis de grau en comunicació audiovisual (CAV que es desenvolupen a Espanya. Per desenvolupar-la hem comptat amb ocupadors i acadèmics experts de l'àmbit de la comunicació audiovisual triats de forma intencional. La rúbrica final desenvolupada, a més de permetre avaluar el grau d'adquisició de les competències professionalitzadores en CAV, permet dibuixar un mapa clar de l'organització i adequació dels processos i metodologies docents. En aquest sentit, la rúbrica pot ser un instrument pedagògic clau per a una futura promoció d'estudiants, i es pot convertir en un instrument que afavoreixi l'avaluació formativa dels alumnes.

  3. Improving clinical research and cancer care delivery in community settings: evaluating the NCI community cancer centers program

    Directory of Open Access Journals (Sweden)

    Fennell Mary L

    2009-09-01

    Full Text Available Abstract Background In this article, we describe the National Cancer Institute (NCI Community Cancer Centers Program (NCCCP pilot and the evaluation designed to assess its role, function, and relevance to the NCI's research mission. In doing so, we describe the evolution of and rationale for the NCCCP concept, participating sites' characteristics, its multi-faceted aims to enhance clinical research and quality of care in community settings, and the role of strategic partnerships, both within and outside of the NCCCP network, in achieving program objectives. Discussion The evaluation of the NCCCP is conceptualized as a mixed method multi-layered assessment of organizational innovation and performance which includes mapping the evolution of site development as a means of understanding the inter- and intra-organizational change in the pilot, and the application of specific evaluation metrics for assessing the implementation, operations, and performance of the NCCCP pilot. The assessment of the cost of the pilot as an additional means of informing the longer-term feasibility and sustainability of the program is also discussed. Summary The NCCCP is a major systems-level set of organizational innovations to enhance clinical research and care delivery in diverse communities across the United States. Assessment of the extent to which the program achieves its aims will depend on a full understanding of how individual, organizational, and environmental factors align (or fail to align to achieve these improvements, and at what cost.

  4. Improving clinical research and cancer care delivery in community settings: evaluating the NCI community cancer centers program.

    Science.gov (United States)

    Clauser, Steven B; Johnson, Maureen R; O'Brien, Donna M; Beveridge, Joy M; Fennell, Mary L; Kaluzny, Arnold D

    2009-09-26

    In this article, we describe the National Cancer Institute (NCI) Community Cancer Centers Program (NCCCP) pilot and the evaluation designed to assess its role, function, and relevance to the NCI's research mission. In doing so, we describe the evolution of and rationale for the NCCCP concept, participating sites' characteristics, its multi-faceted aims to enhance clinical research and quality of care in community settings, and the role of strategic partnerships, both within and outside of the NCCCP network, in achieving program objectives. The evaluation of the NCCCP is conceptualized as a mixed method multi-layered assessment of organizational innovation and performance which includes mapping the evolution of site development as a means of understanding the inter- and intra-organizational change in the pilot, and the application of specific evaluation metrics for assessing the implementation, operations, and performance of the NCCCP pilot. The assessment of the cost of the pilot as an additional means of informing the longer-term feasibility and sustainability of the program is also discussed. The NCCCP is a major systems-level set of organizational innovations to enhance clinical research and care delivery in diverse communities across the United States. Assessment of the extent to which the program achieves its aims will depend on a full understanding of how individual, organizational, and environmental factors align (or fail to align) to achieve these improvements, and at what cost.

  5. NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening.

    Science.gov (United States)

    Thornburg, Christopher C; Britt, John R; Evans, Jason R; Akee, Rhone K; Whitt, James A; Trinh, Spencer K; Harris, Matthew J; Thompson, Jerell R; Ewing, Teresa L; Shipley, Suzanne M; Grothaus, Paul G; Newman, David J; Schneider, Joel P; Grkovic, Tanja; O'Keefe, Barry R

    2018-06-13

    The US National Cancer Institute's (NCI) Natural Product Repository is one of the world's largest, most diverse collections of natural products containing over 230,000 unique extracts derived from plant, marine, and microbial organisms that have been collected from biodiverse regions throughout the world. Importantly, this national resource is available to the research community for the screening of extracts and the isolation of bioactive natural products. However, despite the success of natural products in drug discovery, compatibility issues that make extracts challenging for liquid handling systems, extended timelines that complicate natural product-based drug discovery efforts and the presence of pan-assay interfering compounds have reduced enthusiasm for the high-throughput screening (HTS) of crude natural product extract libraries in targeted assay systems. To address these limitations, the NCI Program for Natural Product Discovery (NPNPD), a newly launched, national program to advance natural product discovery technologies and facilitate the discovery of structurally defined, validated lead molecules ready for translation will create a prefractionated library from over 125,000 natural product extracts with the aim of producing a publicly-accessible, HTS-amenable library of >1,000,000 fractions. This library, representing perhaps the largest accumulation of natural-product based fractions in the world, will be made available free of charge in 384-well plates for screening against all disease states in an effort to reinvigorate natural product-based drug discovery.

  6. Employability of genetic counselors with a PhD in genetic counseling.

    Science.gov (United States)

    Wallace, Jody P; Myers, Melanie F; Huether, Carl A; Bedard, Angela C; Warren, Nancy Steinberg

    2008-06-01

    The development of a PhD in genetic counseling has been discussed for more than 20 years, yet the perspectives of employers have not been assessed. The goal of this qualitative study was to gain an understanding of the employability of genetic counselors with a PhD in genetic counseling by conducting interviews with United States employers of genetic counselors. Study participants were categorized according to one of the following practice areas: academic, clinical, government, industry, laboratory, or research. All participants were responsible for hiring genetic counselors in their institutions. Of the 30 employers interviewed, 23 envisioned opportunities for individuals with a PhD degree in genetic counseling, particularly in academic and research settings. Performing research and having the ability to be a principal investigator on a grant was the primary role envisioned for these individuals by 22/30 participants. Employers expect individuals with a PhD in genetic counseling to perform different roles than MS genetic counselors with a master's degree. This study suggests there is an employment niche for individuals who have a PhD in genetic counseling that complements, and does not compete with, master's prepared genetic counselors.

  7. Interoperability in digital electrocardiography: harmonization of ISO/IEEE x73-PHD and SCP-ECG.

    Science.gov (United States)

    Trigo, Jesús D; Chiarugi, Franco; Alesanco, Alvaro; Martínez-Espronceda, Miguel; Serrano, Luis; Chronaki, Catherine E; Escayola, Javier; Martínez, Ignacio; García, José

    2010-11-01

    The ISO/IEEE 11073 (x73) family of standards is a reference frame for medical device interoperability. A draft for an ECG device specialization (ISO/IEEE 11073-10406-d02) has already been presented to the Personal Health Device (PHD) Working Group, and the Standard Communications Protocol for Computer-Assisted ElectroCardioGraphy (SCP-ECG) Standard for short-term diagnostic ECGs (EN1064:2005+A1:2007) has recently been approved as part of the x73 family (ISO 11073-91064:2009). These factors suggest the coordinated use of these two standards in foreseeable telecardiology environments, and hence the need to harmonize them. Such harmonization is the subject of this paper. Thus, a mapping of the mandatory attributes defined in the second draft of the ISO/IEEE 11073-10406-d02 and the minimum SCP-ECG fields is presented, and various other capabilities of the SCP-ECG Standard (such as the messaging part) are also analyzed from an x73-PHD point of view. As a result, this paper addresses and analyzes the implications of some inconsistencies in the coordinated use of these two standards. Finally, a proof-of-concept implementation of the draft x73-PHD ECG device specialization is presented, along with the conversion from x73-PHD to SCP-ECG. This paper, therefore, provides recommendations for future implementations of telecardiology systems that are compliant with both x73-PHD and SCP-ECG.

  8. [MD PhD programs: Providing basic science education for ophthalmologists].

    Science.gov (United States)

    Spaniol, K; Geerling, G

    2015-06-01

    Enrollment in MD PhD programs offers the opportunity of a basic science education for medical students and doctors. These programs originated in the USA where structured programs have been offered for many years, but now German universities also run MD PhD programs. The MD PhD programs provided by German universities were investigated regarding entrance requirements, structure and financing modalities. An internet and telephone-based search was carried out. Out of 34 German universities 22 offered MD PhD programs. At 15 of the 22 universities a successfully completed course of studies in medicine was required for enrollment, 7 programs admitted medical students in training and 7 programs required a medical doctoral thesis, which had to be completed with at least a grade of magna cum laude in 3 cases. Financing required scholarships in many cases. Several German universities currently offer MD PhD programs; however, these differ considerably regarding entrance requirements, structure and financing. A detailed analysis investigating the success rates of these programs (e.g. successful completion and career paths of graduates) would be of benefit.

  9. Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)

    Energy Technology Data Exchange (ETDEWEB)

    McDonough,M.; Li, V.; Flashman, E.; Chowdhury, R.; Mohr, C.; Lienard, B.; Zondlo, J.; Oldham, N.; Clifton, I.; et al.

    2006-01-01

    Cellular and physiological responses to changes in dioxygen levels in metazoans are mediated via the posttranslational oxidation of hypoxia-inducible transcription factor (HIF). Hydroxylation of conserved prolyl residues in the HIF-{alpha} subunit, catalyzed by HIF prolyl-hydroxylases (PHDs), signals for its proteasomal degradation. The requirement of the PHDs for dioxygen links changes in dioxygen levels with the transcriptional regulation of the gene array that enables the cellular response to chronic hypoxia; the PHDs thus act as an oxygen-sensing component of the HIF system, and their inhibition mimics the hypoxic response. We describe crystal structures of the catalytic domain of human PHD2, an important prolyl-4-hydroxylase in the human hypoxic response in normal cells, in complex with Fe(II) and an inhibitor to 1.7 Angstroms resolution. PHD2 crystallizes as a homotrimer and contains a double-stranded {beta}-helix core fold common to the Fe(II) and 2-oxoglutarate-dependant dioxygenase family, the residues of which are well conserved in the three human PHD enzymes (PHD 1-3). The structure provides insights into the hypoxic response, helps to rationalize a clinically observed mutation leading to familial erythrocytosis, and will aid in the design of PHD selective inhibitors for the treatment of anemia and ischemic disease.

  10. PhD students’ expectations from their supervisors: A qualitative content analysis

    Directory of Open Access Journals (Sweden)

    SH Rimaz

    2015-03-01

    Full Text Available Introduction: Quality of research in PhD programs increases if supervisors become aware of students' expectations from them. This qualitative study aimed to explore expectations of PhD students from their supervisors was done.   Methods: This qualitative content analysis study was conducted on 22 graduated PhD students of Iran University of Medical Sciences, in 2014. The samples were purposefully selected and interviewed. All interviews were recorded and transcribed verbatim.   Results: After analyzing and coding data, it was found that PhD students have four main expectations from their supervisors. These expectations consist of scientific support including help with selection of subject, preparation and registration of proposal, data collection and support for writing and examination of the thesis. Developing scientific skills and help with preparing manuscripts were other expectations. Emotional-social support with five categories including relationship between supervisor-student, general expectations of supervisor, supervisor personality characteristics, needed emotional skills and social activities related to thesis and finally providing adequate resources including financial support and access to facilities inside and outside the university were among the other expectations.   Conclusion: PhD students need to scientific, emotional, social and material supports from their supervisors in the process of performing thesis. These expectations should be told to supervisors.

  11. Strategic innovation between PhD and DNP programs: Collaboration, collegiality, and shared resources.

    Science.gov (United States)

    Edwards, Joellen; Rayman, Kathleen; Diffenderfer, Sandra; Stidham, April

    2016-01-01

    At least 111 schools and colleges of nursing across the nation provide both PhD and DNP programs (AACN, 2014a). Collaboration between nurses with doctoral preparation as researchers (PhD) and practitioners (DNP) has been recommended as essential to further the profession; that collaboration can begin during the educational process. The purpose of this paper is to describe the development and implementation of successful DNP and PhD program collaboration, and to share the results of that collaboration in an educational setting. Faculty set strategic goals to maximize the effectiveness and efficiency of both new DNP and existing PhD programs. The goals were to promote collaboration and complementarity between the programs through careful capstone and dissertation differentiation, complementary residency activities, joint courses and inter-professional experiences; promote collegiality in a blended on-line learning environment through shared orientation and intensive on-campus sessions; and maximize resources in program delivery through a supportive organizational structure, equal access to technology support, and shared faculty responsibilities as appropriate to terminal degrees. Successes such as student and faculty accomplishments, and challenges such as managing class size and workload, are described. Collaboration, collegiality and the sharing of resources have strengthened and enriched both programs and contributed to the success of students, faculty. These innovative program strategies can provide a solid foundation for DNP and PhD collaboration. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Predicting the "graduate on time (GOT)" of PhD students using binary logistics regression model

    Science.gov (United States)

    Shariff, S. Sarifah Radiah; Rodzi, Nur Atiqah Mohd; Rahman, Kahartini Abdul; Zahari, Siti Meriam; Deni, Sayang Mohd

    2016-10-01

    Malaysian government has recently set a new goal to produce 60,000 Malaysian PhD holders by the year 2023. As a Malaysia's largest institution of higher learning in terms of size and population which offers more than 500 academic programmes in a conducive and vibrant environment, UiTM has taken several initiatives to fill up the gap. Strategies to increase the numbers of graduates with PhD are a process that is challenging. In many occasions, many have already identified that the struggle to get into the target set is even more daunting, and that implementation is far too ideal. This has further being progressing slowly as the attrition rate increases. This study aims to apply the proposed models that incorporates several factors in predicting the number PhD students that will complete their PhD studies on time. Binary Logistic Regression model is proposed and used on the set of data to determine the number. The results show that only 6.8% of the 2014 PhD students are predicted to graduate on time and the results are compared wih the actual number for validation purpose.

  13. NCI-FDA Interagency Oncology Task Force Workshop Provides Guidance for Analytical Validation of Protein-based Multiplex Assays | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    An NCI-FDA Interagency Oncology Task Force (IOTF) Molecular Diagnostics Workshop was held on October 30, 2008 in Cambridge, MA, to discuss requirements for analytical validation of protein-based multiplex technologies in the context of its intended use. This workshop developed through NCI's Clinical Proteomic Technologies for Cancer initiative and the FDA focused on technology-specific analytical validation processes to be addressed prior to use in clinical settings. In making this workshop unique, a case study approach was used to discuss issues related to

  14. The PH-D proposal - A manned mission to PHOBOS and Deimos

    Science.gov (United States)

    Singer, S. F.

    The rationale for a manned mission to the satellites of Mars is discussed. The view has been expressed that NASA must define a major program to follow the Shuttle and to utilize it. However, such a program could not be initiated and proceed without public support, and to obtain this support, public interest would have to be excited. It is shown that, of a number of possible targets for manned exploration in the solar system, Mars appears to be the only possible candidate. Attention is given to a comparison of three Mars missions, a Mars 1984 mission, a manned landing on Mars surface, a manned landing on Phobos and Deimos (Ph-D project), putting men in Mars orbit, the capabilities of the Ph-D mission, a description of the spacecraft, a Ph-D project operations plan, and aspects of timing, technology, and costs.

  15. GM-PHD Filter Combined with Track-Estimate Association and Numerical Interpolation

    Directory of Open Access Journals (Sweden)

    Jinguang Chen

    2015-01-01

    Full Text Available For the standard Gaussian mixture probability hypothesis density (GM-PHD filter, the number of targets can be overestimated if the clutter rate is too high or underestimated if the detection rate is too low. These problems seriously affect the accuracy of multitarget tracking for the number and the value of measurements and clutters cannot be distinguished and recognized. Therefore, we proposed an improved GM-PHD filter to tackle these problems. Firstly, a track-estimate association was implemented in the filtering process to detect and remove false-alarm targets. Secondly, a numerical interpolation technique was used to compensate the missing targets caused by low detection rate. At the end of this paper, simulation results were presented to demonstrate the proposed GM-PHD algorithm is more effective in estimating the number and state of targets than the previous ones.

  16. Cooperative Localization for Multi-AUVs Based on GM-PHD Filters and Information Entropy Theory

    Directory of Open Access Journals (Sweden)

    Lichuan Zhang

    2017-10-01

    Full Text Available Cooperative localization (CL is considered a promising method for underwater localization with respect to multiple autonomous underwater vehicles (multi-AUVs. In this paper, we proposed a CL algorithm based on information entropy theory and the probability hypothesis density (PHD filter, aiming to enhance the global localization accuracy of the follower. In the proposed framework, the follower carries lower cost navigation systems, whereas the leaders carry better ones. Meanwhile, the leaders acquire the followers’ observations, including both measurements and clutter. Then, the PHD filters are utilized on the leaders and the results are communicated to the followers. The followers then perform weighted summation based on all received messages and obtain a final positioning result. Based on the information entropy theory and the PHD filter, the follower is able to acquire a precise knowledge of its position.

  17. Science PhD career preferences: levels, changes, and advisor encouragement.

    Directory of Open Access Journals (Sweden)

    Henry Sauermann

    Full Text Available Even though academic research is often viewed as the preferred career path for PhD trained scientists, most U.S. graduates enter careers in industry, government, or "alternative careers." There has been a growing concern that these career patterns reflect fundamental imbalances between the supply of scientists seeking academic positions and the availability of such positions. However, while government statistics provide insights into realized career transitions, there is little systematic data on scientists' career preferences and thus on the degree to which there is a mismatch between observed career paths and scientists' preferences. Moreover, we lack systematic evidence whether career preferences adjust over the course of the PhD training and to what extent advisors exacerbate imbalances by encouraging their students to pursue academic positions. Based on a national survey of PhD students at tier-one U.S. institutions, we provide insights into the career preferences of junior scientists across the life sciences, physics, and chemistry. We also show that the attractiveness of academic careers decreases significantly over the course of the PhD program, despite the fact that advisors strongly encourage academic careers over non-academic careers. Our data provide an empirical basis for common concerns regarding labor market imbalances. Our results also suggest the need for mechanisms that provide PhD applicants with information that allows them to carefully weigh the costs and benefits of pursuing a PhD, as well as for mechanisms that complement the job market advice advisors give to their current students.

  18. Science PhD career preferences: levels, changes, and advisor encouragement.

    Science.gov (United States)

    Sauermann, Henry; Roach, Michael

    2012-01-01

    Even though academic research is often viewed as the preferred career path for PhD trained scientists, most U.S. graduates enter careers in industry, government, or "alternative careers." There has been a growing concern that these career patterns reflect fundamental imbalances between the supply of scientists seeking academic positions and the availability of such positions. However, while government statistics provide insights into realized career transitions, there is little systematic data on scientists' career preferences and thus on the degree to which there is a mismatch between observed career paths and scientists' preferences. Moreover, we lack systematic evidence whether career preferences adjust over the course of the PhD training and to what extent advisors exacerbate imbalances by encouraging their students to pursue academic positions. Based on a national survey of PhD students at tier-one U.S. institutions, we provide insights into the career preferences of junior scientists across the life sciences, physics, and chemistry. We also show that the attractiveness of academic careers decreases significantly over the course of the PhD program, despite the fact that advisors strongly encourage academic careers over non-academic careers. Our data provide an empirical basis for common concerns regarding labor market imbalances. Our results also suggest the need for mechanisms that provide PhD applicants with information that allows them to carefully weigh the costs and benefits of pursuing a PhD, as well as for mechanisms that complement the job market advice advisors give to their current students.

  19. Education of MSc and PhD Students in Fluid Power and Mechatronics at DTU

    DEFF Research Database (Denmark)

    Conrad, Finn

    1996-01-01

    The paper deals with education of MSc and PhD students in engineering areas fluid power and mechatronics at the Technical Univ of Denmark, DTU, Lyngby. The new education structure and programs for MSc and PhD students adapted to the change and development of technologies. Focus is on two of twenty...... engineering profilies:(1) Engineeing Design and Product Development and (2)Control Engineering which give possibilitie for specialisation in fluid power and mechatronics design and productdevelopment. Synthesis, design and self-learning competency have a high priority taking the importance of training...

  20. The 7th Workshop for PhD Students in Object-Oriented Systems

    DEFF Research Database (Denmark)

    1997-01-01

    the communication and cooperation between them. In a year of the PhDOOS network the workshop is the main event where we meet face-to-face. Between workshops we stay in touch through our mailing list. More information on the PhDOOS network can be found at http://purl.org/net/PhDOOS.......It is a tradition at ECOOP conferences to have a workshop for PhD students, conducted by the network of PhD Students in Object-Oriented Systems (PhDOOS). The purpose of this network is to help leveraging the collective resources of young researchers in the object community by improving...

  1. An interview with James Wilbur, Ph.D. General Manager, Life Sciences, Meso Scale Discovery.

    Science.gov (United States)

    Wilbur, James

    2004-06-01

    James L. Wilbur, Ph.D. received a Bachelor's degree from the University of California, San Diego and a Ph.D. in Chemistry from Stanford University. After completing an NIH Postdoctoral Fellowship with Professor George M. Whitesides in the Department of Chemistry at Harvard University, he joined IGEN International, Inc., where he held a variety of positions in Research and Development. During that time, he was part of the team that developed the core technology and products for Meso Scale Discovery. He assumed his current position in 2001 when Meso Scale Discovery launched the products discussed here.

  2. A Content Analysis on the Subjects of Hospitality PhD Dissertations in Turkey

    Directory of Open Access Journals (Sweden)

    İbrahim GİRİTLİOĞLU

    2014-12-01

    Full Text Available The aim of this paper is to review the evaluation of hospitality dissertations as their subjects and their completed years. To perform on this aim, completed PhD dissertations were reached on National Dissertation Centre website at Turkish Higher Education Institute (YOK. According to study’s results, hospitality marketing strategies and organizational behavior in hospitality industry were the most popular research subjects on the dissertations in Turkey. However, the most completed PhD dissertations at the hospitality area was the year of 2011

  3. Deconstructing doctoral dissertations: how many papers does it take to make a PhD?

    Science.gov (United States)

    Hagen, Nils T

    2010-11-01

    A collection of coauthored papers is the new norm for doctoral dissertations in the natural and biomedical sciences, yet there is no consensus on how to partition authorship credit between PhD candidates and their coauthors. Guidelines for PhD programs vary but tend to specify only a suggested range for the number of papers to be submitted for evaluation, sometimes supplemented with a requirement for the PhD candidate to be the principal author on the majority of submitted papers. Here I use harmonic counting to quantify the actual amount of authorship credit attributable to individual PhD graduates from two Scandinavian universities in 2008. Harmonic counting corrects for the inherent inflationary and equalizing biases of routine counting methods, thereby allowing the bibliometrically identifiable amount of authorship credit in approved dissertations to be analyzed with unprecedented accuracy. Unbiased partitioning of authorship credit between graduates and their coauthors provides a post hoc bibliometric measure of current PhD requirements, and sets a de facto baseline for the requisite scientific productivity of these contemporary PhD's at a median value of approximately 1.6 undivided papers per dissertation. Comparison with previous census data suggests that the baseline has shifted over the past two decades as a result of a decrease in the number of submitted papers per candidate and an increase in the number of coauthors per paper. A simple solution to this shifting baseline syndrome would be to benchmark the amount of unbiased authorship credit deemed necessary for successful completion of a specific PhD program, and then monitor for departures from this level over time. Harmonic partitioning of authorship credit also facilitates cross-disciplinary and inter-institutional analysis of the scientific output from different PhD programs. Juxtaposing bibliometric benchmarks with current baselines may thus assist the development of harmonized guidelines and

  4. Top tips for PhD thesis examination: nurse clinicians, researchers and novices.

    Science.gov (United States)

    Cleary, Michelle; Horsfall, Jan; Hunt, Glenn E

    2012-01-01

    Interestingly, there are very few guidelines in the literature to assist novice nurse PhD examiners. In this paper, we aim to provide information to nurses, researchers or early career academics who have little experience in assessing a university thesis. The article provides background information about recent changes in the university sector; overviews some research on experienced examiners views; presents factors that differentiate between high and low quality PhD theses; and outlines some pointers that may be useful when marking at the doctoral level. Copyright © 2011 Elsevier Ltd. All rights reserved.

  5. The role of PHD2 mutations in the pathogenesis of erythrocytosis

    Directory of Open Access Journals (Sweden)

    Gardie B

    2014-07-01

    of EPO transcription. The α subunits of the hypoxia-inducible transcription factor are hydroxylated by three prolyl hydroxylase domain (PHD enzymes, which belong to the iron and 2-oxoglutarate-dependent oxygenase superfamily. Sequence analysis of the genes encoding the PHDs in patients with erythrocytosis has revealed heterozygous germline mutations only occurring in Egl nine homolog 1 (EGLN1, also known as PHD2, the gene that encodes PHD2. To date, 24 different EGLN1 mutations comprising missense, frameshift, and nonsense mutations have been described. The phenotypes associated with the patients carrying these mutations are fairly homogeneous and typically limited to erythrocytosis with normal to elevated EPO. However, exceptions exist; for example, there is one case with development of concurrent paraganglioma (PHD2-H374R. Analysis of the erythrocytosis-associated PHD2 missense mutations has shown heterogeneous results. Structural studies reveal that mutations can affect different domains of PHD2. Some are close to the hypoxia-inducible transcription factor α/2-oxoglutarate or the iron binding sites for PHD2. In silico studies demonstrate that the mutations do not always affect fully conserved residues. In vitro and in cellulo studies showed varying effects of the mutations, ranging from mild effects to severe loss of function. The exact mechanism of a potential tumor-suppressor role for PHD2 still needs to be elucidated. A knockin mouse model expressing the first reported PHD2-P317R mutation recapitulates the phenotype observed in humans (erythrocytosis with inappropriately normal serum EPO levels and demonstrates that haploinsufficiency and partial deregulation of PHD2 is sufficient to cause erythrocytosis. Keywords: PHD2, EGLN1, HIF, hypoxia, erythropoietin, erythrocytosis

  6. Time, Concentration, and pH-Dependent Transport and Uptake of Anthocyanins in a Human Gastric Epithelial (NCI-N87 Cell Line

    Directory of Open Access Journals (Sweden)

    Allison A. Atnip

    2017-02-01

    Full Text Available Anthocyanins are the largest class of water soluble plant pigments and a common part of the human diet. They may have many potential health benefits, including antioxidant, anti-inflammatory, anti-cancer, and cardioprotective activities. However, anthocyanin metabolism is not well understood. Studies suggest that anthocyanins absorption may occur in the stomach, in which the acidic pH favors anthocyanin stability. A gastric epithelial cell line (NCI-N87 has been used to study the behavior of anthocyanins at a pH range of 3.0–7.4. This work examines the effects of time (0–3 h, concentration (50–1500 µM, and pH (3.0, 5.0, 7.4 on the transport and uptake of anthocyanins using NCI-N87 cells. Anthocyanins were transported from the apical to basolateral side of NCI-N87 cells in time and dose dependent manners. Over the treatment time of 3 h the rate of transport increased, especially with higher anthocyanin concentrations. The non-linear rate of transport may suggest an active mechanism for the transport of anthocyanins across the NCI-N87 monolayer. At apical pH 3.0, higher anthocyanin transport was observed compared to pH 5.0 and 7.4. Reduced transport of anthocyanins was found to occur at apical pH 5.0.

  7. Association of a single nucleotide polymorphic variation in the human chromosome 19q13.3 with drug responses in the NCI60 cell lines

    DEFF Research Database (Denmark)

    Nissen, K.K.; Vogel, Ulla Birgitte; Nexo, B.A.

    2009-01-01

    the correlations between the responses of the NCI60 cells to different anticancer drugs and their respective alleles of five DNA polymorphisms located in a cancer-related chromosomal area. One polymorphism, located in the 5' noncoding region of the gene ASE-1, alias CD3EAP, proved to be associated with drug...

  8. PhD Crisis Discourse: A Critical Approach to the Framing of the Problem and Some Australian "Solutions"

    Science.gov (United States)

    Cuthbert, Denise; Molla, Tebeje

    2015-01-01

    A feature of HE reform discourse is the tendency to construct the rationale for reform in terms of averting calamity and risk. We refer to this risk talk as "crisis discourse." This study examines the formulation of PhD crisis discourse internationally and in Australia. We find that a key feature of PhD crisis discourse is that…

  9. PhD by Publication as an Argument for Innovation and Technology Transfer: With Emphasis on Africa

    Science.gov (United States)

    Asongu, Simplice A.; Nwachukwu, Jacinta C.

    2018-01-01

    The contribution of African researchers to knowledge by means of scientific publications is low compared to other regions of the world. This paper presents an argument in favour of PhD by publication as a tool for innovation and technology transfer. The conception of PhD by publication used in this study is more suited for doctorates in science…

  10. Challenges of PhD Graduated Nurses for Role Acceptance as a Clinical Educator: A Qualitative Study.

    Science.gov (United States)

    Haghighi Moghadam, Yousef; Atashzadeh-Shoorideh, Foroozan; Abbaszadeh, Abbas; Feizi, Aram

    2017-06-01

    Introduction: Clinical education is the core component of nursing education. PhD graduated nurses who are faculty members can play a main role in clinical instruction. However, there is not clear understanding about the challenges which they may encounter for accepting their role as clinical educator. The aim of this study was to explore the challenges of role acceptance by PhD aduated nurses who are faculty members. Methods: In this qualitative exploratory study a total of 13 participants (8 PhD graduated in nursing, 3 head of departments of nursing, one educational vice chancellor of nursing school, and one nurse) were selected by purposive sampling method. Data were collected by semi-structured, face to face interview and analyzed by conventional content analysis approach developed by Graneheim and Lundman. Results: The main theme emerged from data analysis was "identity threat". This theme had five categories including expectations beyond ability, lack of staff's rely on the performance of PhD graduated nurses, poor clinical competencies, doubtfulness, and obligation. Conclusion: PhD graduated nurses experienced some worries about their role as clinical educators and argued that they have not been prepared for their role. Therefore, policy makers and authorities of nursing schools should support PhD graduated nurses for accepting their new roles as clinical educators. Moreover, some changes in nursing PhD curriculum is needed to improve the clinical competencies of PhD graduated and prepare them for their role as a clinical educator.

  11. Using a nursing theory or a model in nursing PhD dissertations: a qualitative study from Turkey.

    Science.gov (United States)

    Mete, Samiye; Gokçe İsbir, Gozde

    2015-04-01

    The aim of this study was to reveal experiences of nursing students and their advisors using theories and models in their PhD dissertations. The study adopted a descriptive qualitative approach. This study was performed with 10 PhD candidates and their five advisors from nursing faculty. The results of the study were categorized into four. These are reasons for using a theory/model in a PhD dissertation, reasons for preferring a given model, causes of difficulties in using models in PhD dissertations, and facilitating factors of using theories and models in PhD of dissertations. It was also reported to contribute to the methodology of research and professional development of the students and advisors. © 2014 NANDA International, Inc.

  12. The intrinsically disordered domain of the antitoxin Phd chaperones the toxin Doc against irreversible inactivation and misfolding.

    Science.gov (United States)

    De Gieter, Steven; Konijnenberg, Albert; Talavera, Ariel; Butterer, Annika; Haesaerts, Sarah; De Greve, Henri; Sobott, Frank; Loris, Remy; Garcia-Pino, Abel

    2014-12-05

    The toxin Doc from the phd/doc toxin-antitoxin module targets the cellular translation machinery and is inhibited by its antitoxin partner Phd. Here we show that Phd also functions as a chaperone, keeping Doc in an active, correctly folded conformation. In the absence of Phd, Doc exists in a relatively expanded state that is prone to dimerization through domain swapping with its active site loop acting as hinge region. The domain-swapped dimer is not capable of arresting protein synthesis in vitro, whereas the Doc monomer is. Upon binding to Phd, Doc becomes more compact and is secured in its monomeric state with a neutralized active site. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  13. Self-reported needs for improving the supervision competence of PhD supervisors from the medical sciences in Denmark

    DEFF Research Database (Denmark)

    Raffing, Rie; Jensen, Thor Bern; Tønnesen, Hanne

    2017-01-01

    Background: Quality of supervision is a major predictor for successful PhD projects. A survey showed that almost all PhD students in the Health Sciences in Denmark indicated that good supervision was important for the completion of their PhD study. Interestingly, approximately half of the students...... and wishes regarding the content of a new program in supervision, with a special focus on the supervision of PhD students in medical fields. Methods: A semi-structured interview guide was developed, and 20 PhD supervisors from the Graduate School of Health and Medical Sciences at the Faculty of Health...... and Medical Sciences at the University of Copenhagen were interviewed. Empirical data were analysed using qualitative methods of analysis. Results: Overall, the results indicated a general interest in improved competence and development of a new supervision programme. Those who were not interested argued that...

  14. Three new students selected for the ATLAS PhD Grant Scheme

    CERN Multimedia

    Antonella Del Rosso

    2016-01-01

    Initiated in 2013, the ATLAS PhD Grant Scheme aims to enable young, talented and motivated students to work on part of their PhD thesis at CERN. The collaboration has just selected the three students who will start their theses in 2016.   The three students who received the ATLAS grant, which will cover part of their PhD studies. From left to right: Ruth Jacobs (Germany), Artem Basalaev (Russia), Nedaa B I Asbah (Palestine). The ATLAS PhD Grant Scheme was made possible thanks to a large donation by former ATLAS spokespersons Fabiola Gianotti and Peter Jenni, who started the fund with money from the Fundamental Physics Prize they received in 2013. Applications are handled by CERN HR, via this link. The aim of the initiative is to offer a unique educational opportunity to students within the ATLAS collaboration and to give them the possibility to continue their career in particle physics. Selected candidates receive a stipend allowing them to spend one year at CERN, followed by one year at their h...

  15. Regulating Emotions and Aiming for a Ph.D.: Excerpts from "Anthropology Matters"

    Science.gov (United States)

    Hovland, Ingie

    2012-01-01

    In this article I will present a range of experiences of graduate socialisation that have been discussed in past articles in the journal "Anthropology Matters". These are the experiences of social anthropology Ph.D. students in the United Kingdom. The overarching theme for the article is "regulating emotions", and the excerpts…

  16. International Students' Motivation to Pursue and Complete a Ph.D. in the U.S.

    Science.gov (United States)

    Zhou, Ji

    2015-01-01

    This study explores what motivates 19 international students to pursue a Ph.D. at a public research university in the U.S. and, more importantly, what motivates them to persist despite unsatisfying socialization. Based on value-expectancy achievement motivation theory, four motivations emerged: intrinsic interest in research, intrinsic interest in…

  17. Temporary Contracts: Effect on Job Satisfaction and Personal Lives of Recent Phd Graduates

    Science.gov (United States)

    Waaijer, Cathelijn J. F.; Belder, Rosalie; Sonneveld, Hans; van Bochove, Cornelis A.; van der Weijden, Inge C. M.

    2017-01-01

    In this study, we assess the effects of temporary employment on job satisfaction and the personal lives of recent PhD graduates. Temporary employment is becoming increasingly prevalent in many sectors, but has been relatively common in academia, especially for early career scientists. Labor market theory shows temporary employment to have a…

  18. Temporary contracts : Effect on job satisfaction and personal lives of recent PhD graduates

    NARCIS (Netherlands)

    Waaijer, C.J.F.; Belder, R.; Sonneveld, H.; Van, Bochove C.A.; Van, der Weijden I.C.M.

    2017-01-01

    In this study, we assess the effects of temporary employment on job satisfaction and the personal lives of recent PhD graduates. Temporary employment is becoming increasingly prevalent in many sectors, but has been relatively common in academia, especially for early career scientists. Labor market

  19. Women Ph.D. Students in Engineering and a Nuanced Terrain: Avoiding and Revealing Gender

    Science.gov (United States)

    Erickson, Shelley K.

    2012-01-01

    Tensions regarding gender emerged from interviews conducted with 20 women Ph.D. students. This article does not focus explicitly on the reasons for women's continued underrepresentation in engineering. Rather the students' explanations for underrepresentation serve as a case study with which to analyze their gendered experiences. They avoid freely…

  20. The Impact of Institutional Student Support on Graduation Rates in US Ph.D. Programmes

    Science.gov (United States)

    Bolli, Thomas; Agasisti, Tommaso; Johnes, Geraint

    2015-01-01

    Using National Research Council data, we investigate the determinants of graduation rates in US Ph.D. programmes. We emphasise the impact that support and facilities offered to doctoral students have on completion rates. Significant, strong and positive effects are found for the provision of on-site graduate conferences and dedicated workspace,…

  1. The first recipients of the ATLAS PhD Grant Scholarship Programme 2014

    CERN Multimedia

    Marcelloni, Claudia

    2014-01-01

    First recipients of the ATLAS PhD Grant Scholarship 2014 : With certificates, Lailin Xu, Josefina Alconada, and Gagik Vardanyan. The selection committee members, IFAE Barcelona’s Martine Bosman, Fabiola Gianotti, Peter Jenni and from CERN HR James PurvisProgramme: Lailin Xu, Josefina Alconada, and Gagik Vardanyan

  2. Low immediate scientific yield of the PhD among medical doctors

    DEFF Research Database (Denmark)

    Fosbol, Emil L.; Fosbøl, Philip Loldrup; Rerup, Sofie

    2016-01-01

    . Scientific activity over time was assessed independently of author-rank and inactivity was measured relative to the date of graduation. Factors associated with inactivity were identified using multivariable logistic regression. 88.6 % of the PhD theses were conducted in internal medicine vs. 11...

  3. Improving completion rates of students in biomedical PhD programs: an interventional study.

    Science.gov (United States)

    Viđak, Marin; Tokalić, Ružica; Marušić, Matko; Puljak, Livia; Sapunar, Damir

    2017-08-25

    Analysis of graduation success at the University of Split School of Medicine PhD programs conducted in 2011 revealed that only 11% of students who enrolled and completed their graduate coursework between 1999 and 2011 earned a doctoral degree. In this prospective cohort study we evaluated and compared three PhD programs within the same medical school, where the newest program, called Translational Research in Biomedicine (TRIBE), established in the academic year 2010/11, aimed to increase the graduation rate through an innovative approach. The intervention in the new program was related to three domains: redefined recruitment strategy, strict study regulations, and changes to the curriculum. We compared performance of PhD students between the new and existing programs and analyzed their current status, time to obtain a degree (from enrolment to doctorate), age at doctorate, number of publications on which the thesis was based and the impact factor of journals in which these were published. These improvement strategies were associated with higher thesis completion rate and reduced time to degree for students enrolled in the TRIBE program. There was no change in the impact factor or number of publications that were the basis for the doctoral theses. Our study describes good practices which proved useful in the design or reform of the PhD training program.

  4. Gender and Doctoral Studies: The Perceptions of Ph.D. Students in an American University

    Science.gov (United States)

    Kurtz-Costes, Beth; Helmke, Laura Andrews; Ulku-Steiner, Beril

    2006-01-01

    Twenty students enrolled in Ph.D. programmes were interviewed to examine the role of gender in their academic experiences. Gender was examined in three ways: gender of the student, gender of the student's faculty supervisor and gender make-up of the faculty within the student's department or academic unit. All students reported the importance of…

  5. Learning Opportunities in PhD Supervisory Talks: A Social Constructionist Perspective

    Science.gov (United States)

    Tian, Wenwen; Singhasiri, Wareesiri

    2016-01-01

    Although PhD supervision has been recognised as an educative process and a complex pedagogy for decades, there is little research into on-site pedagogic processes. Informed by social constructionism and a Foucauldian approach, this qualitative case study explores how learning opportunities were created by analysing both a supervisor's verbal…

  6. Crystallization of Doc and the Phd-Doc toxin-antitoxin complex.

    Science.gov (United States)

    Garcia-Pino, Abel; Dao-Thi, Minh-Hoa; Gazit, Ehud; Magnuson, Roy David; Wyns, Lode; Loris, Remy

    2008-11-01

    The phd/doc addiction system is responsible for the stable inheritance of lysogenic bacteriophage P1 in its plasmidic form in Escherichia coli and is the archetype of a family of bacterial toxin-antitoxin modules. The His66Tyr mutant of Doc (Doc(H66Y)) was crystallized in space group P2(1), with unit-cell parameters a = 53.1, b = 198.0, c = 54.1 A, beta = 93.0 degrees . These crystals diffracted to 2.5 A resolution and probably contained four dimers of Doc in the asymmetric unit. Doc(H66Y) in complex with a 22-amino-acid C-terminal peptide of Phd (Phd(52-73Se)) was crystallized in space group C2, with unit-cell parameters a = 111.1, b = 38.6, c = 63.3 A, beta = 99.3 degrees , and diffracted to 1.9 A resolution. Crystals of the complete wild-type Phd-Doc complex belonged to space group P3(1)21 or P3(2)21, had an elongated unit cell with dimensions a = b = 48.9, c = 354.9 A and diffracted to 2.4 A resolution using synchrotron radiation.

  7. Originality and the PhD: what is it and how can it be demonstrated?

    Science.gov (United States)

    Gill, Paul; Dolan, Gina

    2015-07-01

    To explore the concept of originality in doctoral research and outline ways in which doctoral candidates can begin to identify, formulate and articulate their individual contributions to knowledge. Originality is a major feature of doctoral research but considerable confusion exists regarding what can and cannot constitute originality in the PhD and how the contribution to knowledge can be demonstrated clearly. This is a discussion paper. A review of relevant, published literature relating to originality in the PhD. Many doctoral candidates merely outline why they believe their work to be original, instead of demonstrating critically how and in what way their research makes a meaningful contribution to the body of knowledge. The concept of originality in the PhD is complex and multi-faceted. Identifying and conveying originality in doctoral research takes considerable time, contemplation and effort. This process is, however, integral to the PhD itself, and the skills acquired are essential for post-doctoral development. A good doctoral thesis should clearly outline the different ways in which the work is original. A succinct, focused, critical appraisal of the specific contribution to knowledge is preferable to an exhaustive list.

  8. An Analysis of Written Feedback on a PhD Thesis

    Science.gov (United States)

    Kumar, Vijay; Stracke, Elke

    2007-01-01

    This paper offers an interim analysis of written feedback on a first draft of a PhD thesis. It first looks at two sources of data: in-text feedback and overall feedback. Looking at how language is used in its situational context, we then coded the feedback and developed a model for analysis based on three fundamental functions of speech:…

  9. Classifying Australian PhD Theses: Linking Research and Library Practices

    Science.gov (United States)

    Macauley, Peter; Evans, Terry; Pearson, Margot

    2010-01-01

    This article draws on the findings from, and the methods and approach used in the provision of a database of Australian PhD thesis records for the period 1987 to 2006, coded by Research Fields, Courses and Disciplines (RFCD) fields of study. Importantly, the project was not merely the creation of yet another database but something that constitutes…

  10. Three graduate students receive Virginia Tech's first AdvanceVT Ph.D. fellowships

    OpenAIRE

    Cox, Clara B.

    2004-01-01

    AdvanceVT, a comprehensive program that promotes and enhances the careers of women in science and engineering, has awarded its first three Ph.D. fellowships as part of an ongoing effort to increase the number of women electing to pursue academic careers.

  11. Identification and characterization of small molecule inhibitors of a PHD finger§

    Science.gov (United States)

    Wagner, Elise K.; Nath, Nidhi; Flemming, Rod; Feltenberger, John B.; Denu, John M.

    2012-01-01

    A number of histone-binding domains are implicated in cancer through improper binding of chromatin. In a clinically reported case of acute myeloid leukemia (AML), a genetic fusion protein between nucleoporin 98 and the third plant homeodomain (PHD) finger of JARID1A drives an oncogenic transcriptional program that is dependent on histone binding by the PHD finger. By exploiting the requirement for chromatin binding in oncogenesis, therapeutics targeting histone readers may represent a new paradigm in drug development. In this study, we developed a novel small molecule screening strategy that utilizes HaloTag technology to identify several small molecules that disrupt binding of the JARID1A PHD finger to histone peptides. Small molecule inhibitors were validated biochemically through affinity pull downs, fluorescence polarization, and histone reader specificity studies. One compound was modified through medicinal chemistry to improve its potency while retaining histone reader selectivity. Molecular modeling and site-directed mutagenesis of JARID1A PHD3 provided insights into the biochemical basis of competitive inhibition. PMID:22994852

  12. Measuring efficiency of university-industry Ph.D. projects using best worst method

    NARCIS (Netherlands)

    Salimi, N.; Rezaei, J.

    2016-01-01

    A collaborative Ph.D. project, carried out by a doctoral candidate, is a type of collaboration between university and industry. Due to the importance of such projects, researchers have considered different ways to evaluate the success, with a focus on the outputs of these projects. However, what

  13. Measuring efficiency of university-industry Ph.D. projects using best worst method.

    Science.gov (United States)

    Salimi, Negin; Rezaei, Jafar

    A collaborative Ph.D. project, carried out by a doctoral candidate, is a type of collaboration between university and industry. Due to the importance of such projects, researchers have considered different ways to evaluate the success, with a focus on the outputs of these projects. However, what has been neglected is the other side of the coin-the inputs. The main aim of this study is to incorporate both the inputs and outputs of these projects into a more meaningful measure called efficiency. A ratio of the weighted sum of outputs over the weighted sum of inputs identifies the efficiency of a Ph.D. The weights of the inputs and outputs can be identified using a multi-criteria decision-making (MCDM) method. Data on inputs and outputs are collected from 51 Ph.D. candidates who graduated from Eindhoven University of Technology. The weights are identified using a new MCDM method called Best Worst Method (BWM). Because there may be differences in the opinion of Ph.D. candidates and supervisors on weighing the inputs and outputs, data for BWM are collected from both groups. It is interesting to see that there are differences in the level of efficiency from the two perspectives, because of the weight differences. Moreover, a comparison between the efficiency scores of these projects and their success scores reveals differences that may have significant implications. A sensitivity analysis divulges the most contributing inputs and outputs.

  14. Rethinking the Ph.D. in English. Carnegie Essays on the Doctorate: English.

    Science.gov (United States)

    Lunsford, Andrea Abernethy

    The Carnegie Foundation commissioned a series of essays as part of the Carnegie Initiative on the Doctorate (CID). The essays and essayists represent six disciplines that are part of the CID: chemistry, education, English, history, mathematics, and neuroscience. The essay explores the Ph.D. in English and suggests changes the author would make in…

  15. Winning the PhD Game: Evocative Playing of Snakes and Ladders

    Science.gov (United States)

    Dickie, Carolyn

    2011-01-01

    The purpose of this paper is to describe a qualitative approach to developing an understanding of the lived experiences of PhD students. Rather than relying on textbook reports and theories about studying a higher degree by research, by allowing the students' voices to be heard, explicit and conscious research can be used to generate appropriate…

  16. Liberal Arts Colleges and the Production of PhD Economists

    Science.gov (United States)

    Jefferson, Philip N.; Magenheim, Ellen

    2015-01-01

    Data from the National Science Foundation (2014) indicate that at least one PhD in economics was awarded to a Swarthmore College graduate in every year since 1966. The authors' purpose in this article is to consider factors that may have contributed to the high number of PhDs in economics awarded to Swarthmore College graduates. While there is…

  17. As others see us: what PhD students say about supervisors.

    Science.gov (United States)

    Yarwood-Ross, Lee; Haigh, Carol

    2014-09-01

    To explore the attitudes that doctoral students share with each other in an online postgraduate discussion forum. The supervisory role is pivotal to the successful completion of a PhD. Student satisfaction surveys are implemented by some universities, but there is currently no research that has investigated PhD students' experiences of supervision in the less formal environment of an online postgraduate discussion forum. Data were collected between September and December 2012 from the Postgraduate Forum, which receives posts from the global student community. The keywords used in the search were 'supervisor(s)' and 'supervision'. The data were analysed using thematic analysis. All relevant titles and posts from between January 2002 and the end of December 2012 were searched. The authors discovered five major themes: communication difficulties, control and engagement, academic bullying, lack of trust, and desertion. The relationship between students and supervisors is vital to successful PhD completion, and this study has provided some of the experiences students share with each other in an online postgraduate discussion forum. The online discussion forum provided an insight into students' perspectives of supervision but as it is asynchronous, there is limited analysis. Further research incorporating synchronous data collection methods would be helpful to examine students' experiences in greater detail. This study shows how an online postgraduate forum can be used as a source of data to gain an insight into PhD students' perspectives of supervision.

  18. Peer and Faculty Mentoring for Students Pursuing a PhD in Gerontology

    Science.gov (United States)

    Webb, Alicia K.; Wangmo, Tenzin; Ewen, Heidi H.; Teaster, Pamela B.; Hatch, Laurie R.

    2009-01-01

    The Graduate Center for Gerontology at the University of Kentucky incorporates three levels of mentoring in its PhD program. This project assessed satisfaction with peer and faculty mentoring and explored their perceived benefits and purposes. Core and affiliate faculty and current and graduated students were surveyed. Participants seemed…

  19. What We Know about the Dramatic Increase in PhD Degrees and ...

    African Journals Online (AJOL)

    Reforms in doctoral education are being shaped by the changing needs of society, of research modes, and of a changed labor markets for PhD holders. ... systems, such as the introduction of postgraduate schools that help implement and initiate innovations in doctoral education on a campus with an eye to high quality.

  20. Analysis of Citations to Books in Chemistry PhD Dissertations in an Era of Transition

    Science.gov (United States)

    Flaxbart, David

    2018-01-01

    A citation analysis of chemistry PhD dissertations at the University of Texas at Austin yielded data on how often graduate students cite books in their bibliographies, and on the characteristics of the books cited, in terms of age and local ownership. The analysis examined samples of dissertations selected from five discrete years--1988, 2006,…

  1. Work organization and mental health problems in PhD students

    NARCIS (Netherlands)

    Levecque, K.; Anseel, F.; Beuckelaer, A. de; Van Der Heyden, J.; Gisle, L.

    2017-01-01

    Research policy observers are increasingly concerned about the potential impact of current academic working conditions on mental health, particularly in PhD students. The aim of the current study is threefold. First, we assess the prevalence of mental health problems in a representative sample of

  2. Is a PhD a necessary requirement for lecturers in a`Medical School ...

    African Journals Online (AJOL)

    user

    2005-04-01

    Apr 1, 2005 ... universities did not require a PhD or equivalent qualifications as a minimum requirement for appointment to the ... report of 2002, Common-wealth year books. 1997/8 and 2002, ..... threatens to erode teaching standards and.

  3. ChemSession'08 - 5. Warsaw Seminar of the PhD Students in Chemistry - Abstracts

    International Nuclear Information System (INIS)

    Madura, I.

    2008-01-01

    Book of Abstracts consists of short descriptions of presentations: 5 lectures and 127 posters presented during ChemSession'08 - 5 th Warsaw Seminar of the PhD Students in Chemistry. Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also found

  4. UK PhD Assessment in Accounting and Finance: Social Capital in Action

    Science.gov (United States)

    Smith, Sarah Jane; Urquhart, Vivien

    2018-01-01

    Assessment lies at the centre of PhD degree quality standards, with quality assurance relying on independent external examiners. This study investigates the role of the viva and the selection of external examiners from within the accounting and finance discipline across UK institutions. A questionnaire survey and follow-up interviews with…

  5. ChemSession'09 - 6. Warsaw Seminar of the PhD Students in Chemistry - Abstracts

    International Nuclear Information System (INIS)

    2009-01-01

    Book of Abstracts contains short descriptions of presentations 3 lectures and 105 posters presented during ChemSession'09 - 6 th Warsaw Seminar of the PhD Students in Chemistry. Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also found

  6. Determinants of PhD Completion Time at the University of Ibadan ...

    African Journals Online (AJOL)

    Apart from conducting an extensive exploratory analysis on PhD production in the university, a binary logistic regression model was also fitted. The dichotomous responses were: completion on time and completion over time. The fitted logistic regression shows that only 10% of PhDs have predicted probability of completion ...

  7. Completing a PhD by Publication: A Review of Australian Policy and Implications for Practice

    Science.gov (United States)

    Jackson, Denise

    2013-01-01

    There is increasing impetus for higher-degree-by-research students to publish during candidature. Research performance, including higher degree completions and publication output, commonly determines university funding, and doctorates with publishing experience are better positioned for a career in softening academic labour markets. The PhD by…

  8. Exploring challenges of the reproductive health PhD curriculum: A qualitative research

    Directory of Open Access Journals (Sweden)

    Sh Kohan

    2016-07-01

    Full Text Available Introduction: Enhancing the quality and dynamicity of higher education programs requires continuous evaluation of curriculums. Reproductive health PhD program was established in 2006 in Iran while recommending that its curriculum be evaluated by assessing graduates’ performance in workplace and surveying students, faculty members and managers. This study aimed to explore challenges of the curriculum of reproductive health PhD program. Methods: Employing a qualitative content analysis approach and using purposive and sometimes opportunistic sampling, experiences and viewpoints of 33 graduates and students of reproductive health PhD program, educational managers and reproductive health board members about the curriculum of reproductive health PhD program were collected through individual interviews and notes in 2014-15. Data were transcribed and important expressions were coded. Classification of similar codes led to preliminary categories. Five main categories were extracted by further classifications. Results: The five main categories included inadequacy of course topics and contents, challenges of student education, failure in realizing curriculum goals, long research period, and ambiguity in graduates’ professional status were appeared; each of these included various subcategories. Conclusion: Results showed that the curriculum of reproductive health PhD program required revisions to meet the program’s mission and designing courses such as sexual health and reinforcing the clinical nature of the program were necessary. Moreover, the results emphasized that the establishment of an independent educational department of reproductive health for managing higher education affairs and greater supervision of the reproductive health board on educational affairs was necessary. Furthermore, reproductive health specialists should be employed in different positions to meet society’s reproductive health needs.

  9. Does working with industry come at a price? A study of doctoral candidates’ performance in collaborative vs. non-collaborative Ph.D. projects

    NARCIS (Netherlands)

    Salimi, Negin; Bekkers, Rudi; Frenken, Koen

    2015-01-01

    Collaborative Ph.D. projects between university and industry constitute an important aspect of university–industry collaboration, yet has remained under-researched thus far. The specific question this paper asks is how collaborative Ph.D. projects perform compared to non-collaborative Ph.D.

  10. The status of PhD education in economic, social, and administrative sciences between 2005 and 2008.

    Science.gov (United States)

    Farley, Joel F; Wang, Chi-Chuan; Blalock, Susan J

    2010-09-10

    To describe the funding, education, enrollment, and graduation patterns from economic, social, and administrative sciences PhD programs in colleges and schools of pharmacy in the United States. Economic, social, and administrative sciences PhD programs were identified from the American Association of Colleges of Pharmacy (AACP) Web site. A 41-item online survey instrument was sent to the director of graduate studies of each identified program. Only programs offering a PhD degree were included in the study. Of the 26 programs surveyed, 20 (77%) provided useable responses to the survey instrument. Approximately 91% of PhD programs guarantee funding to incoming students with an average commitment of 2.9 years. On average, students were paid a stipend of $18,000 per year for commitments to research and teaching assistantships, each averaging approximately 2 years in length. Programs admitted an average of 3.5 students per year and graduated approximately 85% of entering students. The majority of students are non-US citizens and accept positions in either academic or industrial positions after graduation. Most economic, social, and administrative sciences PhD programs guarantee funding to incoming PhD candidates. Programs offering funding packages significantly below the average may be at a competitive disadvantage. It is unclear whether the number of students graduating from PhD programs is adequate to fulfill academic and industrial needs.

  11. Career intentions of PhD students in nursing: A cross-sectional survey.

    Science.gov (United States)

    Bai, XiaoLing; Luo, ZhongChen; Lou, Ting; Pang, Jin; Tang, SiYuan

    2018-05-01

    Despite the rapid growth of Chinese nursing PhD programs, little is known about the career intentions of students in this field. To investigate the career intentions of nursing PhD students. Online cross-sectional survey. Nursing PhD students at Chinese universities. An online questionnaire was designed and the data were analyzed using SPSS. The mean age of the participants was 31.53 ± 4.92 years, and most were female (89.9%), married (74.2%), and had been employed previously (69.7%). Most intended to work in the city where their family lived (34.8%) or near their previous workplace (32.6%). Most (60.7%) desired to work in an educational institution (e.g., a university or college). The most common expected salary was 8000-11,999 RMB/month. The work benefits perceived as indispensable were "Five Insurances and One Fund" (77.5%), good educational resources for children (59.6%), financial allowances for PhD graduates (52.8%), staff dormitories/housing subsidies (50.6%), and tenure (50.6%). Nursing education (75.3%) and research (70.8%) were the most favored fields. The key job characteristics were the opportunity to put strengths to fullest use (79.8%), time to conduct research (60.7%), and work-life balance (51.7%). The key research conditions included a good research incentive mechanism (77.5%), a Basic Scientific Research Foundation (68.5%), opportunity to apply to conduct research projects (66.3%), and the nursing team's atmosphere regarding research (64.0%), and 91.0% were eager to study abroad (e.g., as part of an international exchange). Nursing PhD students would like to work in their hometown or near their previous workplace. Most preferred working in an educational institution, and the most popular fields were nursing education and research (rather than clinical care), despite the high demand of hospital management for nursing PhD graduates. Flexible work, high-quality research conditions, a certain salary, work benefits, and training were key

  12. Grantee Spotlight: Manuel L. Penichet, M.D., Ph.D. - Reprogramming the Immune System to Kill Cancer

    Science.gov (United States)

    Dr. Manuel L. Penichet, former CURE K01 trainee and NCI R01 grantee, aims to genetically engineer antibodies that can be used to directly target and eliminate cancer cells and also stimulate the body’s immune system to fight and destroy cancer.

  13. Self-reported needs for improving the supervision competence of PhD supervisors from the medical sciences in Denmark

    Directory of Open Access Journals (Sweden)

    Rie Raffing

    2017-10-01

    Full Text Available Abstract Background Quality of supervision is a major predictor for successful PhD projects. A survey showed that almost all PhD students in the Health Sciences in Denmark indicated that good supervision was important for the completion of their PhD study. Interestingly, approximately half of the students who withdrew from their program had experienced insufficient supervision. This led the Research Education Committee at the University of Copenhagen to recommend that supervisors further develop their supervision competence. The aim of this study was to explore PhD supervisors’ self-reported needs and wishes regarding the content of a new program in supervision, with a special focus on the supervision of PhD students in medical fields. Methods A semi-structured interview guide was developed, and 20 PhD supervisors from the Graduate School of Health and Medical Sciences at the Faculty of Health and Medical Sciences at the University of Copenhagen were interviewed. Empirical data were analysed using qualitative methods of analysis. Results Overall, the results indicated a general interest in improved competence and development of a new supervision programme. Those who were not interested argued that, due to their extensive experience with supervision, they had no need to participate in such a programme. The analysis revealed seven overall themes to be included in the course. The clinical context offers PhD supervisors additional challenges that include the following sub-themes: patient recruitment, writing the first article, agreements and scheduled appointments and two main groups of students, in addition to the main themes. Conclusions The PhD supervisors reported the clear need and desire for a competence enhancement programme targeting the supervision of PhD students at the Faculty of Health and Medical Sciences. Supervision in the clinical context appeared to require additional competence. Trial registration The Scientific Ethical Committee

  14. Self-reported needs for improving the supervision competence of PhD supervisors from the medical sciences in Denmark.

    Science.gov (United States)

    Raffing, Rie; Jensen, Thor Bern; Tønnesen, Hanne

    2017-10-23

    Quality of supervision is a major predictor for successful PhD projects. A survey showed that almost all PhD students in the Health Sciences in Denmark indicated that good supervision was important for the completion of their PhD study. Interestingly, approximately half of the students who withdrew from their program had experienced insufficient supervision. This led the Research Education Committee at the University of Copenhagen to recommend that supervisors further develop their supervision competence. The aim of this study was to explore PhD supervisors' self-reported needs and wishes regarding the content of a new program in supervision, with a special focus on the supervision of PhD students in medical fields. A semi-structured interview guide was developed, and 20 PhD supervisors from the Graduate School of Health and Medical Sciences at the Faculty of Health and Medical Sciences at the University of Copenhagen were interviewed. Empirical data were analysed using qualitative methods of analysis. Overall, the results indicated a general interest in improved competence and development of a new supervision programme. Those who were not interested argued that, due to their extensive experience with supervision, they had no need to participate in such a programme. The analysis revealed seven overall themes to be included in the course. The clinical context offers PhD supervisors additional challenges that include the following sub-themes: patient recruitment, writing the first article, agreements and scheduled appointments and two main groups of students, in addition to the main themes. The PhD supervisors reported the clear need and desire for a competence enhancement programme targeting the supervision of PhD students at the Faculty of Health and Medical Sciences. Supervision in the clinical context appeared to require additional competence. The Scientific Ethical Committee for the Capital Region of Denmark. Number: H-3-2010-101, date: 2010.09.29.

  15. Experiències de realitat augmentada en biblioteques : estat de la qüestió

    Directory of Open Access Journals (Sweden)

    Arroyo Vázquez, Natalia

    2016-06-01

    Full Text Available Objectiu: donar a conèixer les experiències més significatives d'ús de la realitat augmentada en biblioteques, amb una especial atenció als resultats obtinguts, les aportacions i les limitacions que s'han de tenir en compte. -- Metodologia: revisió bibliogràfica, selecció i anàlisi d'experiències sobre l'ús de realitat augmentada en biblioteques. -- Resultats: tot i ser una tecnologia recent, són diversos els exemples d'ús de la realitat augmentada en biblioteques. No obstant això, es fa necessari donar a conèixer els resultats d'aquestes experiències, de manera que puguin servir no solament com a model, sinó també per conèixer què és el que funciona. Es presenta als professionals un catàleg d'usos de la realitat augmentada en biblioteques, dels quals s'analitzen de forma crítica els possibles beneficis i limitacions, i s'agrupen en set apartats segons la utilitat: geolocalització, contextualització històrica, exposicions i altres activitats, publicacions, enriquiment dels espais físics, alfabetització i ludificació i, finalment, usos professionals.Objetivo: dar a conocer las experiencias más significativas de uso de la realidad aumentada en bibliotecas, con una especial atención a los resultados obtenidos, las aportaciones y las limitaciones que se deben tener en cuenta. -- Metodología: revisión bibliográfica, selección y análisis de experiencias sobre el uso de realidad aumentada en bibliotecas. -- Resultados: a pesar de ser una tecnología reciente, son varios los ejemplos de uso de la realidad aumentada en bibliotecas. Sin embargo, se hace necesario dar a conocer los resultados de dichas experiencias, de forma que puedan servir no solo como modelo, sino también para conocer qué es lo que funciona. Se presenta a los profesionales un catálogo de usos de la realidad aumentada en bibliotecas, analizados de forma crítica sus posibles beneficios y limitaciones, agrupados en siete apartados según la utilidad

  16. Experiències de realitat augmentada en biblioteques : estat de la qüestió

    Directory of Open Access Journals (Sweden)

    Arroyo Vázquez, Natalia

    2016-06-01

    Full Text Available Objectiu: donar a conèixer les experiències més significatives d'ús de la realitat augmentada en biblioteques, fent una especial atenció als resultats obtinguts, les aportacions i les limitacions que s'han de tenir en compte. -- Metodologia: revisió bibliogràfica, selecció i anàlisi d'experiències sobre l'ús de la realitat augmentada en biblioteques. -- Resultats: malgrat ser una tecnologia recent, els exemples d'ús de la realitat augmentada en biblioteques són diversos. No obstant això, es fa necessari donar a conèixer els resultats d'aquestes experiències, de manera que puguin servir no solament com a model, sinó també per conèixer què és el que funciona. Es presenta als professionals un catàleg d'usos de la realitat augmentada en biblioteques, dels quals s'analitzen de forma crítica els possibles beneficis i limitacions, i s'agrupen en set apartats segons la utilitat: geolocalització, contextualització històrica, exposicions i altres activitats, publicacions, enriquiment dels espais físics, alfabetització i ludificació i, finalment, usos professionals.Objetivo: dar a conocer las experiencias más significativas de uso de la realidad aumentada en bibliotecas, con una especial atención a los resultados obtenidos, las aportaciones y las limitaciones que se deben tener en cuenta. -- Metodología: revisión bibliográfica, selección y análisis de experiencias sobre el uso de la realidad aumentada en bibliotecas. -- Resultados: a pesar de ser una tecnología reciente, son varios los ejemplos de uso de la realidad aumentada en bibliotecas. Sin embargo, se hace necesario dar a conocer los resultados de dichas experiencias, de forma que puedan servir no solo como modelo, sino también para conocer qué es lo que funciona. Se presenta a los profesionales un catálogo de usos de la realidad aumentada en bibliotecas, analizados de forma crítica sus posibles beneficios y limitaciones, agrupados en siete apartados según la

  17. MO-E-BRF-01: Research Opportunities in Technology for Innovation in Radiation Oncology (Highlight of ASTRO NCI 2013 Workshop)

    International Nuclear Information System (INIS)

    Hahn, S; Jaffray, D; Chetty, I; Benedict, S

    2014-01-01

    Radiotherapy is one of the most effective treatments for solid tumors, in large part due to significant technological advances associated with, for instance, the ability to target tumors to very high levels of accuracy (within millimeters). Technological advances have played a central role in the success of radiation therapy as an oncologic treatment option for patients. ASTRO, AAPM and NCI sponsored a workshop “Technology for Innovation in Radiation Oncology” at the NCI campus in Bethesda, MD on June 13–14, 2013. The purpose of this workshop was to bring together expert clinicians and scientists to discuss the role of disruptive technologies in radiation oncology, in particular with regard to how they are being developed and translated to clinical practice in the face of current and future challenges and opportunities. The technologies discussed encompassed imaging and delivery aspects, along with methods to enable/facilitate application of them in the clinic. Measures for assessment of the performance of these technologies, such as techniques to validate quantitative imaging, were reviewed. Novel delivery technologies, incorporating efficient and safe delivery mechanisms enabled by development of tools for process automation and the associated field of oncology informatics formed one of the central themes of the workshop. The discussion on disruptive technologies was grounded in the need for evidence of efficacy. Scientists in the areas of technology assessment and bioinformatics provided expert views on different approaches toward evaluation of technology efficacy. Clinicians well versed in clinical trials incorporating disruptive technologies (e.g. SBRT for early stage lung cancer) discussed the important role of these technologies in significantly improving local tumor control and survival for these cohorts of patients. Recommendations summary focused on the opportunities associated with translating the technologies into the clinic and assessing their

  18. MO-E-BRF-01: Research Opportunities in Technology for Innovation in Radiation Oncology (Highlight of ASTRO NCI 2013 Workshop)

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, S [University of Pennsylvania, Philadelphia, PA (United States); Jaffray, D [Princess Margaret Hospital, Toronto, ON (Canada); Chetty, I [Henry Ford Health System, Detroit, MI (United States); Benedict, S [UC Davis Cancer Center, Sacramento, CA (United States)

    2014-06-15

    Radiotherapy is one of the most effective treatments for solid tumors, in large part due to significant technological advances associated with, for instance, the ability to target tumors to very high levels of accuracy (within millimeters). Technological advances have played a central role in the success of radiation therapy as an oncologic treatment option for patients. ASTRO, AAPM and NCI sponsored a workshop “Technology for Innovation in Radiation Oncology” at the NCI campus in Bethesda, MD on June 13–14, 2013. The purpose of this workshop was to bring together expert clinicians and scientists to discuss the role of disruptive technologies in radiation oncology, in particular with regard to how they are being developed and translated to clinical practice in the face of current and future challenges and opportunities. The technologies discussed encompassed imaging and delivery aspects, along with methods to enable/facilitate application of them in the clinic. Measures for assessment of the performance of these technologies, such as techniques to validate quantitative imaging, were reviewed. Novel delivery technologies, incorporating efficient and safe delivery mechanisms enabled by development of tools for process automation and the associated field of oncology informatics formed one of the central themes of the workshop. The discussion on disruptive technologies was grounded in the need for evidence of efficacy. Scientists in the areas of technology assessment and bioinformatics provided expert views on different approaches toward evaluation of technology efficacy. Clinicians well versed in clinical trials incorporating disruptive technologies (e.g. SBRT for early stage lung cancer) discussed the important role of these technologies in significantly improving local tumor control and survival for these cohorts of patients. Recommendations summary focused on the opportunities associated with translating the technologies into the clinic and assessing their

  19. Incorporació de petites seqüències de cinema comercial en l’ensenyament de les drogodependències. Assaig pilot en l'assignatura de Toxicologia

    Directory of Open Access Journals (Sweden)

    Miguel Rodamilans-Pérez

    2013-01-01

    Full Text Available El Grup d'Innovació Docent Orfila, en el seu projecte per millorar la qualitat de la docència, està assajant la utilització del cinema amb finalitat didàctica. El material didàctic que hem desenvolupat en aquest projecte són petites seqüències de pel·lícules comercials de 3 a 5 minuts, per ser utilitzades com a elements il·lustratius del procés addictiu. Se seleccionen escenes de la filmografia i s'adeqüen als nostres programes docents. Es recull l'opinió dels professors participants, així com la dels alumnes, mitjançant una entrevista personal i una enquesta d'opinió, respectivament.De les entrevistes als professors i de les enquestes d'opinió dels alumnes, es dedueix un alt grau de satisfacció.

  20. The training, careers, and work of Ph.D. physical scientists: Not simply academic

    Science.gov (United States)

    Smith, Steven J.; Pedersen-Gallegos, Liane; Riegle-Crumb, Catherine

    2002-11-01

    We present an in-depth portrait of the training, careers, and work of recent Ph.D. physical scientists. Use of specialized training varies widely, with about half often using knowledge of their Ph.D. specialty area in their jobs. The use of specialized training does not, however, correlate with job satisfaction. In this and other important measures, there are relatively few differences between "academics" and "nonacademics." Important job skills for all employment sectors include writing, oral presentation, management, data analysis, designing projects, critical thinking, and working in an interdisciplinary context. Rankings given by respondents of graduate training in some of these skill areas were significantly lower than the importance of these skills in the workplace. We also found that the rated quality of graduate training varies relatively little by department or advisor. Finally, although nonacademic aspirations among graduate students are fairly common, these do not appear to be well supported while in graduate school.

  1. Publication ethics from the perspective of PhD students of health sciences: a limited experience.

    Science.gov (United States)

    Arda, Berna

    2012-06-01

    Publication ethics, an important subtopic of science ethics, deals with determination of the misconducts of science in performing research or in the dissemination of ideas, data and products. Science, the main features of which are secure, reliable and ethically obtained data, plays a major role in shaping the society. As long as science maintains its quality by being based on reliable and ethically obtained data, it will be possible to maintain its role in shaping the society. This article is devoted to the presentation of opinions of PhD candidate students in health sciences in Ankara concerning publication ethics. The data obtained from 143 PhD students from the fields of medicine, dentistry, pharmacy and veterinary reveal limited but unique experiences. It also shows that plagiarism is one of the worst issues in the publication ethics from the perspective of these young academics.

  2. Examining the British PhD viva: opening new doors or scarring for life?

    Science.gov (United States)

    Carter, Bernie; Whittaker, Karen

    2009-01-01

    The PhD viva -- regardless of its format -- has the potential to be a significant rite of passage for the student. It is an experience that can resonate for months or years afterwards. Part of the challenge is that for everyone involved -- student, supervisory team and examiners -- a degree of end-point uncertainty exists. These ambiguities and tensions are perhaps an inherent part of any examination but are particularly characteristic of the examination of the individual and unique body of work that constitutes the doctoral thesis. In recent years, increased attention has been placed on the processes that surround the examination, aiming to increase transparency, consistency and fairness. However, the process of examining a student and their thesis remains challenging and is surrounded by different agendas, ideologies and practices. This paper examines some of the issues surrounding the PhD viva, primarily focusing on the British viva whilst weaving in commentary about the Australian system.

  3. Discovering and Developing Successful Cardiovascular Therapeutics: A Conversation With James N. Topper, MD, PhD.

    Science.gov (United States)

    Topper, James N; Rutherford, John D

    2016-11-15

    Dr James (also known as Jamie) N. Topper, MD, PhD, serves as Managing General Partner at Frazier Healthcare Partners, where he leads the Life Science Venture practice. In 2011, and 2016, he was named to the Midas List of leading venture capitalists, and, in 2013, he was recognized by Forbes as one of the top 10 healthcare investors. He has >25 years of experience working with entrepreneurs to found and build successful therapeutics-focused companies. Dr Topper holds a BS from the University of Michigan. He received an MD and PhD (in biophysics) from Stanford University School of Medicine. He completed postgraduate training in internal medicine and cardiovascular disease at the Brigham and Women's Hospital in Boston and is board certified in both disciplines. © 2016 American Heart Association, Inc.

  4. Interview with Xiaoli Wang PhD winner of CACA 2016 Young Investigator Award

    Directory of Open Access Journals (Sweden)

    Xiaoli Wang

    2016-07-01

    Full Text Available Xiaoli Wang is currently an R&D Senior Scientist in Agilent’s HPLC instrument R&D group at Agilent Technologies, Waldbronn, Germany. Prior to this, he was an R&D manager in Agilent’s CrossLab Group in the US focusing on development of novel chromatographic columns. He has a B.S. degree in Chemistry from Peking University, Beijing China and a PhD. degree in Analytical Chemistry from the University of Minnesota in 2006. He started his industrial career in the pharmaceutical industry at AstraZeneca for four years before joining Agilent Technologies in 2010. Recently, he won the prestigious 2016 Young Investigator Award from Chinese American Chromatography Association (CACA. This interview was conducted by Roland J.W. Meesters PhD, Editor-in-Chief of Journal of Applied Bioanalysis.

  5. Earth and Space Science Ph.D. Class of 2003 Report released

    Science.gov (United States)

    Keelor, Brad

    AGU and the American Geological Institute (AGI) released on 26 July an employment study of 180 Earth and space science Ph.D. recipients who received degrees from U.S. universities in 2003. The AGU/AGI survey asked graduates about their education and employment, efforts to find their first job after graduation, and experiences in graduate school. Key results from the study include: The vast majority (87%) of 2003 graduates found work in the Earth and space sciences, earning salaries commensurate with or slightly higher than 2001 and 2002 salary averages. Most (64%) graduates were employed within academia (including postdoctoral appointments), with the remainder in government (19%), industry (10%), and other (7%) sectors. Most graduates were positive about their employment situation and found that their work was challenging, relevant, and appropriate for someone with a Ph.D. The percentage of Ph.D. recipients accepting postdoctoral positions (58%) increased slightly from 2002. In contrast, the fields of physics and chemistry showed significant increases in postdoctoral appointments for Ph.D.s during the same time period. As in previous years, recipients of Ph.D.s in the Earth, atmospheric, and ocean sciences (median age of 32.7 years) are slightly older than Ph.D. recipients in most other natural sciences (except computer sciences), which is attributed to time taken off between undergraduate and graduate studies. Women in the Earth, atmospheric,and ocean sciences earned 33% of Ph.D.s in the class of 2003, surpassing the percentage of Ph.D.s earned by women in chemistry (32%) and well ahead of the percentage in computer sciences (20%), physics (19%), and engineering (17%). Participation of other underrepresented groups in the Earth, atmospheric, and ocean sciences remained extremely low.

  6. ChemSession'10: 7. Warsaw Seminar of the PhD Students in Chemistry. Abstracts

    International Nuclear Information System (INIS)

    Madura, I.

    2010-01-01

    Book of Abstracts contains short descriptions of presentations 4 lectures and 151 posters presented during ChemSession'10 - 7 th Warsaw Seminar of the PhD Students in Chemistry (Warsaw, 14.05.2010). Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry, application of the radionuclides and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also mentioned.

  7. Pathways to the PhD in Nursing: An Analysis of Similarities and Differences.

    Science.gov (United States)

    Nehls, Nadine; Barber, Gale; Rice, Elizabeth

    2016-01-01

    New educational pathways are needed to increase the number of doctor of philosophy (PhD)-prepared nurses. To address this need, an early-entry PhD option designed to engage students in PhD coursework and research during the undergraduate nursing major was developed at the University of Wisconsin-Madison. An evaluation comparing the early-entry option with two more conventional entry points was conducted. Three groups (N = 84) comprised the sample: (a) early-entry students admitted as undergraduates or immediately upon graduation (N = 29), (b) mid-entry students with baccalaureate degrees and at least 1 year of work experience (N = 27), and (c) delayed-entry students with master's degrees and 1 or more years of work experience (N = 28). Qualitative and quantitative data were collected from the 3 groups of students who were admitted from 2002 to 2011. The sources of data were transcriptions of individual interviews and reviews of existing data. Seventy-seven percent of the sample participated in the individual interviews. The database review included all students who matriculated into the PhD program. Common themes among the 3 groups included a need for educational funding, the importance of a faculty mentor, and concern about preparation for the teaching role and the academic work environment. The groups were also comparable in terms of research productivity during doctoral study and postgraduation employment. Differences were found on measures of diversity, program progression, and perceptions of clinical competence. The findings provide needed data for the development and expansion of educational pathways to the PhD in nursing. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. Dražen Tutić, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Miljenko Lapaine

    2009-12-01

    Full Text Available Dražen Tutić defended his PhD thesis Stereographic and Other Conformal Map Projections  for Croatia at the Faculty of Geodesy of the University of Zagreb on August 4, 2009. The thesis was evaluated by the Committee: Prof. Emeritus Nedjeljko Frančula, Prof. Dr. Miljenko Lapaine (mentor and Prof. Dr. Dušan Petrovič from the Faculty of Civil and Geodetic Engineering of the University of Ljubljana.

  9. ChemSession'06 - 3rd Seminary of Warsaw PhD Students in Chemistry. Abstracts

    International Nuclear Information System (INIS)

    Zachara, J.; Lulinski, S.; Dobrowolski, J.C.; Raczynska, E.D.; Fuks, L.; Cyranski, M.K.; Stepien, B.T.; Sawicki, M.G.

    2006-01-01

    3 rd Annual Seminary of Warsaw PhD Students in Chemistry presented the latest achievements in chemistry, obtained in all Warsaw universities and scientific institutes. In 2006 participants presented 4 plenary lectures, and 109 posters. Among others, posters covered four disciplines related to the nuclear sciences: (a) radiobiology and radiotherapy, (b) radiation chemistry and photochemistry, (c) isotopic effects in chemistry, and (d) chemical technology

  10. Bucharest PhD Training School : Modern Aspects of Quantum Field Theory and Applications

    CERN Document Server

    2015-01-01

    Bucharest 2015 – Modern Aspects of Quantum Field Theory is part of the CERN – SEENET-MTP PhD Training Program, which consists of a number of seminars in theoretical high energy Physics. This is the second seminar organized by this Program. Here are some photos from this event held in Bucharest between 8-14 November 2015. The previous seminar was organized in Belgrade, under the name Belgrade 2015 - Supergravity.

  11. PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks

    OpenAIRE

    Baker, Lindsey A.; Allis, C. David; Wang, Gang G.

    2008-01-01

    Histone covalent modifications regulate many, if not all, DNA-templated processes, including gene expression and DNA damage response. The biological consequences of histone modifications are mediated partially by evolutionarily conserved “reader/effector” modules that bind to histone marks in a modification- and context-specific fashion and subsequently enact chromatin changes or recruit other proteins to do so. Recently, the Plant Homeodomain (PHD) finger has emerged as a class of specialize...

  12. PHD fingers in human diseases: Disorders arising from misinterpreting epigenetic marks

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Lindsey A. [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States); Allis, C. David [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States)], E-mail: alliscd@rockefeller.edu; Wang, Gang G. [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States)], E-mail: gwang@rockefeller.edu

    2008-12-01

    Histone covalent modifications regulate many, if not all, DNA-templated processes, including gene expression and DNA damage response. The biological consequences of histone modifications are mediated partially by evolutionarily conserved 'reader/effector' modules that bind to histone marks in a modification- and context-specific fashion and subsequently enact chromatin changes or recruit other proteins to do so. Recently, the Plant Homeodomain (PHD) finger has emerged as a class of specialized 'reader' modules that, in some instances, recognize the methylation status of histone lysine residues, such as histone H3 lysine 4 (H3K4). While mutations in catalytic enzymes that mediate the addition or removal of histone modifications (i.e., 'writers' and 'erasers') are already known to be involved in various human diseases, mutations in the modification-specific 'reader' proteins are only beginning to be recognized as contributing to human diseases. For instance, point mutations, deletions or chromosomal translocations that target PHD fingers encoded by many genes (such as recombination activating gene 2 (RAG2), Inhibitor of Growth (ING), nuclear receptor-binding SET domain-containing 1 (NSD1) and Alpha Thalassaemia and Mental Retardation Syndrome, X-linked (ATRX)) have been associated with a wide range of human pathologies including immunological disorders, cancers, and neurological diseases. In this review, we will discuss the structural features of PHD fingers as well as the diseases for which direct mutation or dysregulation of the PHD finger has been reported. We propose that misinterpretation of the epigenetic marks may serve as a general mechanism for human diseases of this category. Determining the regulatory roles of histone covalent modifications in the context of human disease will allow for a more thorough understanding of normal and pathological development, and may provide innovative therapeutic strategies

  13. PHD fingers in human diseases: Disorders arising from misinterpreting epigenetic marks

    International Nuclear Information System (INIS)

    Baker, Lindsey A.; Allis, C. David; Wang, Gang G.

    2008-01-01

    Histone covalent modifications regulate many, if not all, DNA-templated processes, including gene expression and DNA damage response. The biological consequences of histone modifications are mediated partially by evolutionarily conserved 'reader/effector' modules that bind to histone marks in a modification- and context-specific fashion and subsequently enact chromatin changes or recruit other proteins to do so. Recently, the Plant Homeodomain (PHD) finger has emerged as a class of specialized 'reader' modules that, in some instances, recognize the methylation status of histone lysine residues, such as histone H3 lysine 4 (H3K4). While mutations in catalytic enzymes that mediate the addition or removal of histone modifications (i.e., 'writers' and 'erasers') are already known to be involved in various human diseases, mutations in the modification-specific 'reader' proteins are only beginning to be recognized as contributing to human diseases. For instance, point mutations, deletions or chromosomal translocations that target PHD fingers encoded by many genes (such as recombination activating gene 2 (RAG2), Inhibitor of Growth (ING), nuclear receptor-binding SET domain-containing 1 (NSD1) and Alpha Thalassaemia and Mental Retardation Syndrome, X-linked (ATRX)) have been associated with a wide range of human pathologies including immunological disorders, cancers, and neurological diseases. In this review, we will discuss the structural features of PHD fingers as well as the diseases for which direct mutation or dysregulation of the PHD finger has been reported. We propose that misinterpretation of the epigenetic marks may serve as a general mechanism for human diseases of this category. Determining the regulatory roles of histone covalent modifications in the context of human disease will allow for a more thorough understanding of normal and pathological development, and may provide innovative therapeutic strategies wherein 'chromatin readers' stand as potential drug

  14. ChemSession'11 - 8. Warsaw Seminar of the PhD Students in Chemistry - Abstracts

    International Nuclear Information System (INIS)

    Madura, I.

    2011-01-01

    Book of Abstracts contains short descriptions of presentations: 4 lectures, 1 communication and 149 posters presented during ChemSession'11 - 8 th Warsaw Seminar of the PhD Students in Chemistry (Warsaw, 13.05.2011). Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry, application of the radionuclides and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also mentioned.

  15. ChemSession'07 - 4th Seminary of Warsaw PhD Students in Chemistry. Abstracts

    International Nuclear Information System (INIS)

    Dobrowolski, J.C.; Ostrowski, S.; Madura, I.; Sporzynski, A.; Szatylowicz, H.; Zubrowska, A.

    2007-01-01

    4 th Annual Seminary of Warsaw PhD Students in Chemistry presented the latest achievements in chemistry, obtained in all Warsaw universities and scientific institutes. In 2007 participants presented 4 plenary lectures, and 101 posters. Among others, posters covered four disciplines related to the nuclear sciences: (a) radiobiology and radiotherapy, (b) radiation chemistry and photochemistry, (c) isotopic effects in chemistry, and (d) chemical technology

  16. L’avaluació de competències a l’Educació Superior: el cas d’un màster universitari

    Directory of Open Access Journals (Sweden)

    Xavier Ma. Triadó i Ivern

    2013-01-01

    Full Text Available La implantació de les competències és una tasca que ha anat incorporant-se paulatinament pels docents de la universitat espanyola amb l’entrada en vigor del EEES. Tot i això, encara s’està lluny d’aconseguir nivells òptims d’avaluació de les mateixes. Aquest article permet reflexionar sobre algunes bones practiques al respecte i sobre les dificultats i limitacions que apareixen en voler implementar un canvi en les metodologies docents, en el marc d’un màster universitari. Els resultats indiquen el grau en què s’han avaluat i adquirit tant les competències genèriques com especifiques en l’educació superior.

  17. Management of Stress and Anxiety Among PhD Students During Thesis Writing: A Qualitative Study.

    Science.gov (United States)

    Bazrafkan, Leila; Shokrpour, Nasrin; Yousefi, Alireza; Yamani, Nikoo

    2016-01-01

    Today, postgraduate students experience a variety of stresses and anxiety in different situations of academic cycle. Stress and anxiety have been defined as a syndrome shown by emotional exhaustion and reduced personal goal achievement. This article addresses the causes and different strategies of coping with this phenomena by PhD students at Iranian Universities of Medical Sciences. The study was conducted by a qualitative method using conventional content analysis approach. Through purposive sampling, 16 postgraduate medical sciences PhD students were selected on the basis of theoretical sampling. Data were gathered through semistructured interviews and field observations. Six hundred fifty-four initial codes were summarized and classified into 4 main categories and 11 subcategories on the thematic coding stage dependent on conceptual similarities and differences. The obtained codes were categorized under 4 themes including "thesis as a major source of stress," "supervisor relationship," "socioeconomic problem," and "coping with stress and anxiety." It was concluded that PhD students experience stress and anxiety from a variety of sources and apply different methods of coping in effective and ineffective ways. Purposeful supervision and guidance can reduce the cause of stress and anxiety; in addition, coping strategy must be in a thoughtful approach, as recommended in this study.

  18. "PhD Comics" author Jorge Cham on the power of procrastination

    CERN Multimedia

    Stefania Pandolfi

    2015-01-01

    From Tuesday, 22 to Friday, 25 September, Jorge Cham visited CERN. The PHD Movie 2 was screened in the Main Auditorium  and the cartoonist also took part in one of the Researchers' Night events.    Jorge Cham in the CERN Control Centre. On the first day, the author of the comic strip Piled Higher and Deeper (PhD Comics) visited the CERN Control Centre, the Synchrocyclotron, the CMS Service Cavern and the ATLAS control room. On Thursday, he had a busy afternoon, starting with signing copies of his books and then giving a talk entitled “The Power of Procrastination” in a packed Main Auditorium. He made the audience laugh by narrating his experience as a graduate student in robotics at Stanford University, recounting how he started drawing PhD Comics and how it rapidly became popular in universities all over the world. He then analysed the frustrations and anxieties commonly experienced by any graduate student, causing...

  19. Using Simulation in Nursing PhD Education: Facilitating Application of Responsible Conduct of Research Principles.

    Science.gov (United States)

    Clayton, Margaret F; Supiano, Katherine; Wilson, Rebecca; Lassche, Madeline; Latendresse, Gwen

    Simulation is a standard clinical nursing educational approach; however, simulation is rarely used in nonclinical nursing education. In doctor of philosophy (PhD) programs, ethical content about responsible conduct of research (RCR) is traditionally didactic, presented early in the program of study. Ethics content merits review before students begin the dissertation phase; thus, the purpose of this project was to design and implement simulated scenarios to help students apply RCR principles prior to beginning independent research. Two scenarios were developed: (a) a potential protocol change discussed in a research team meeting and (b) an in-home data collection experience with an elderly participant and her daughter. Actors were trained faculty volunteers, playing roles outside their usual academic positions. Faculty facilitated scenarios by posing questions as cues related to desired learning outcomes as scenarios unfolded. Eleven nursing PhD students and 6 faculty participated. Debriefing facilitated discussion of RCR principles, common research quandaries, and suggested scenario revisions. Faculty, expert observation, and video-review showed that younger and less experienced students tried to give the "right" answer rather than implement RCR appropriate solutions. Students with more clinical experience had difficulty adopting the less familiar researcher role. Overall, simulation is a novel and useful way to enhance RCR content in PhD programs. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Forensic odontology education:from undergraduate to PhD - a Brazilian experience.

    Science.gov (United States)

    Dietrichkeit Pereira, J G; Frontanilla Recalde, T S; Barreto Costa, P; Jacometti, V; Vigorito Magalhães, L; Alves Da Silva, R H

    2017-12-01

    Forensic Odontology is a topic present in the majority of Dental Schools in Brazil, and due to this reality, some universities develop activities related to undergraduate and graduate students, from the Dentistry course until the Ph.D. degree. To present the education experience related to Forensic Odontology at School of Dentistry of Ribeirão Preto (USP - University of São Paulo), showing the strategies and activities in the different degrees (Dental course, Forensic Odontology Specialization Program, Specific Professional Training, Master, and Ph.D.). To the undergraduate students, many activities are developed in order to demonstrate all the possibilities that Forensic Dentistry allow, including theoretical and practical activities; in the Forensic Odontology Specialization Program, the dentists are trained to act as Forensic Odontologists in all its amplitude; in the Specific Professional Training, some courses are available, related to specific topics as DVI, Forensic Facial Reconstruction, Auditor in Dental Care Insurance and others; and in the Master and Ph.D. Programs, the professionals receive training in skills like teaching, research, student's guidance and others. In Brazil, Forensic Odontology is a well-known field in Dentistry and universities develop an important role in training a qualified workforce.

  1. Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways

    Directory of Open Access Journals (Sweden)

    Javier Rodriguez

    2016-03-01

    Full Text Available Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG dependent enzymes and, although the biochemistry is well understood, until now only a few substrates have been described for these enzymes. Using quantitative interaction proteomics, we screened for substrates of the proline hydroxylase PHD3 and the asparagine hydroxylase FIH, which regulate the HIF-mediated hypoxic response. We were able to identify hundreds of potential substrates. Enrichment analysis revealed that the potential substrates of both hydroxylases cluster in the same pathways but frequently modify different nodes of signaling networks. We confirm that two proteins identified in our screen, MAPK6 (Erk3 and RIPK4, are indeed hydroxylated in a FIH- or PHD3-dependent mechanism. We further determined that FIH-dependent hydroxylation regulates RIPK4-dependent Wnt signaling, and that PHD3-dependent hydroxylation of MAPK6 protects the protein from proteasomal degradation.

  2. Pioneering women in American mathematics the pre-1940 PhD's

    CERN Document Server

    Green, Judy

    2008-01-01

    More than 14 percent of the PhD's awarded in the United States during the first four decades of the twentieth century went to women, a proportion not achieved again until the 1980s. This book is the result of a study in which the authors identified all of the American women who earned PhD's in mathematics before 1940, and collected extensive biographical and bibliographical information about each of them. By reconstructing as complete a picture as possible of this group of women, Green and LaDuke reveal insights into the larger scientific and cultural communities in which they lived and worked. The book contains an extended introductory essay, as well as biographical entries for each of the 228 women in the study. The authors examine family backgrounds, education, careers, and other professional activities. They show that there were many more women earning PhD's in mathematics before 1940 than is commonly thought. Extended biographies and bibliographical information are available from the companion website fo...

  3. Ternary copper(II) complex: NCI60 screening, toxicity studies, and evaluation of efficacy in xenograft models of nasopharyngeal carcinoma

    Science.gov (United States)

    Chu, Tai-Lin; Abdul Aziz, Norazlin; Mohd Kornain, Noor-Kaslina; Samiulla, D. S.; Lo, Kwok-Wai; Ng, Chew-Hee

    2018-01-01

    Copper(II) ternary complex, [Cu(phen)(C-dmg)(H2O)]NO3 was evaluated against a panel of cell lines, tested for in vivo efficacy in nasopharyngeal carcinoma xenograft models as well as for toxicity in NOD scid gamma mice. The Cu(II) complex displayed broad spectrum cytotoxicity against multiple cancer types, including lung, colon, central nervous system, melanoma, ovarian, and prostate cancer cell lines in the NCI-60 panel. The Cu(II) complex did not cause significant induction of cytochrome P450 (CYP) 3A and 1A enzymes but moderately inhibited CYP isoforms 1A2, 2C9, 2C19, 2D6, 2B6, 2C8 and 3A4. The complex significantly inhibited tumor growth in nasopharyngeal carcinoma xenograft bearing mice models at doses which were well tolerated without causing significant or permanent toxic side effects. However, higher doses which resulted in better inhibition of tumor growth also resulted in toxicity. PMID:29329342

  4. Effect of bcl-2 antisense oligodexynucleotides on chemotherapy efficacy of Vp-16 on human small cell lung cancer cell line NCI-H69

    International Nuclear Information System (INIS)

    He Wenqian; Liu Zhonghua

    2007-01-01

    Objective: To study the effect of bcl-2 antisense oligodexynucleotides on chemotherapy efficacy of Vp-16 on human small cell lung cancer cell line NCI-H69. Methods: Cultured NCI-H69 cells were derided into 4 groups: bcl-2 antisense oligodexynucleotides (ASODN) added, sense oligodexynucleotides (SODN) added, nonsense oligodexynucleotides (NSODN) added and control (no nucleotides added), the oligodexynucleotides were transfected into the cultured cells with oligofectamine. The cellular expression of Bcl-2 protein 72h later was examined with Western-Blot. The four different groups of cultured tumor cells were treated with etopside(Vp-16) at different concentrations (0, 0.25, 0.5, 1.0, 2.0 and 4.0 μg/ml) for 48hr then the cell survival fraction was assessed with MTY test. Results: The apoptotic rate of cells in the ASODN group was significantly higher than that of the control group, also, the survival fraction of cells in ASODN group was significantly lower than that of the control group. The Bcl-2 protein expression in ASODN group was significantly lower than that in the control group, but no inhibition was observed in SODN and NSODN groups. Conclusion: The bcl-2 ASODN could enhance the sensitivity to chemotherapy with Vp-16 in small cell lung cancer cell line NCI-H69 by effectively blocking bcl-2 gene expression. (authors)

  5. Resveratrol enhances radiosensitivity of human non-small cell lung cancer NCI-H838 cells accompanied by inhibition of nuclear factor-kappa B activation

    International Nuclear Information System (INIS)

    Liao, Hui-Fen; Kuo Cheng-Deng; Yang, Yuh-Cheng; Lin, Chin-Ping; Tai, Hung-Chi; Chen, Yu-Jen; Chen, Yu-Yawn

    2005-01-01

    Resveratrol, a polyphenol in red wine, possesses many pharmacological activities including cardio-protection, chemoprevention, anti-tumor effects, and nuclear factor-kappa B (NF-κB) inactivation. The present study was designed to evaluate the effects and possible mechanism of resveratrol in enhancing radiosensitivity of lung cancer cells. Human non-small cell lung cancer NCI-H838 cells were irradiated with or without resveratrol pretreatment. The surviving fraction and sensitizer enhancement ratio (SER) were estimated by using a colony formation assay and linear-quadratic model. The cell-cycle distribution was evaluated by using prospidium iodide staining and flow cytometry. An enzyme-linked immunosorbent assay (ELISA)-based assay with immobilized oligonucleotide was performed to assess the DNA binding activity of NF-κB. Resveratrol had no direct growth-inhibitory effect on NCI-H838 cells treated for 24 hours with doses up to 25 μM. Pretreatment with resveratrol significantly enhanced cell killing by radiation, with an SER up to 2.2. Radiation activated NF-κB, an effect reversed by resveratrol pretreatment. Resveratrol resulted in a decrease of cells in the G 0 /G 1 phase and an increase in the S phase. Our results demonstrate that resveratrol enhances the radiosensitivity of NCI-H838 cells accompanied by NF-κB inhibition and S-phase arrest. (author)

  6. Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

    DEFF Research Database (Denmark)

    Madsen, Chris D; Pedersen, Jesper Thorhauge; Venning, Freja A

    2015-01-01

    , which can be prevented by simultaneous depletion of HIF-1α. Treatment with the PHD inhibitor DMOG in an orthotopic breast cancer model significantly decreases spontaneous metastases to the lungs and liver, associated with decreased tumour stiffness and fibroblast activation. PHD2 depletion in CAFs co......-injected with tumour cells similarly prevents CAF-induced metastasis to lungs and liver. Our data argue that reversion of CAFs towards a less active state is possible and could have important clinical implications....

  7. Biomedical Science Ph.D. Career Interest Patterns by Race/Ethnicity and Gender.

    Directory of Open Access Journals (Sweden)

    Kenneth D Gibbs

    Full Text Available Increasing biomedical workforce diversity remains a persistent challenge. Recent reports have shown that biomedical sciences (BMS graduate students become less interested in faculty careers as training progresses; however, it is unclear whether or how the career preferences of women and underrepresented minority (URM scientists change in manners distinct from their better-represented peers. We report results from a survey of 1500 recent American BMS Ph.D. graduates (including 276 URMs that examined career preferences over the course of their graduate training experiences. On average, scientists from all social backgrounds showed significantly decreased interest in faculty careers at research universities, and significantly increased interest in non-research careers at Ph.D. completion relative to entry. However, group differences emerged in overall levels of interest (at Ph.D. entry and completion, and the magnitude of change in interest in these careers. Multiple logistic regression showed that when controlling for career pathway interest at Ph.D. entry, first-author publication rate, faculty support, research self-efficacy, and graduate training experiences, differences in career pathway interest between social identity groups persisted. All groups were less likely than men from well-represented (WR racial/ethnic backgrounds to report high interest in faculty careers at research-intensive universities (URM men: OR 0.60, 95% CI: 0.36-0.98, p = 0.04; WR women: OR: 0.64, 95% CI: 0.47-0.89, p = 0.008; URM women: OR: 0.46, 95% CI: 0.30-0.71, p<0.001, and URM women were more likely than all other groups to report high interest in non-research careers (OR: 1.93, 95% CI: 1.28-2.90, p = 0.002. The persistence of disparities in the career interests of Ph.D. recipients suggests that a supply-side (or "pipeline" framing of biomedical workforce diversity challenges may limit the effectiveness of efforts to attract and retain the best and most

  8. Increasing PhD students’ employability by focusing on the academic entrepreneurship. The analysis of the entrepreneurial competences

    Directory of Open Access Journals (Sweden)

    Sabina Hodzic

    2016-05-01

    Full Text Available The aim of the present study was to explore the perspective for entrepreneurship among PhD students coming from variety of disciplines. More precisely, to identify the most important entrepreneurial competences for succeeding in the entrepreneurial venture, to explore whether these competences are being developed during the 3rd cycle studies, and to explore the entrepreneurial intentions of the future doctors. In order to choose the most important entrepreneurial competences, individual semi-structured interviews with ten entrepreneurs from different fields were conducted. In addition, the importance of each competence was evaluated in form of the questionnaire, by seventeen entrepreneurs. After the qualitative and quantitative analysis of the interviews and the questionnaire, 20 competences were selected as the most important entrepreneurial competences. These 20 competences were then evaluated by 50 PhD students from different fields of study. They evaluated the importance of each entrepreneurial competence, the level of its development during their PhD studies, and indicated their entrepreneurial intentions after finishing the PhD. The most important and the most developed competences are presented in the results. In addition, the results showed relatively high entrepreneurial intentions in case of not finding a job after the PhD and in general. These results imply the need for incorporating some sort of entrepreneurial training and the development of entrepreneurial competences adapted to each subject area during the PhD studies.

  9. Factors that facilitate or inhibit interest of domestic students in the engineering PhD: A mixed methods study

    Science.gov (United States)

    Howell Smith, Michelle C.

    Given the increasing complexity of technology in our society, the United States has a growing demand for a more highly educated technical workforce. Unfortunately, the proportion of United States citizens earning a PhD in engineering has been declining and there is concern about meeting the economic, national security and quality of life needs of our country. This mixed methods sequential exploratory instrument design study identified factors that facilitate or inhibit interest in engineering PhD programs among domestic engineering undergraduate students in the United States. This study developed a testable theory for how domestic students become interested in engineering PhD programs and a measure of that process, the Exploring Engineering Interest Inventory (EEII). The study was conducted in four phases. The first phase of the study was a qualitative grounded theory exploration of interest in the engineering PhD. Qualitative data were collected from domestic engineering students, engineering faculty and industry professional who had earned a PhD in engineering. The second phase, instrument development, developed the Exploring Engineering Interest Inventory (EEII), a measurement instrument designed with good psychometric properties to test a series of preliminary hypotheses related to the theory generated in the qualitative phase. In the third phase of the study, the EEII was used to collect data from a larger sample of junior and senior engineering majors. The fourth phase integrated the findings from the qualitative and quantitative phases. Four factors were identified as being significant influences of interest in the engineering PhD: Personal characteristics, educational environment, misperceptions of the economic and personal costs, and misperceptions of engineering work. Recommendations include increasing faculty encouragement of students to pursue an engineering PhD and programming to correct the misperceptions of the costs of the engineering PhD and the

  10. Publishing scientific papers based on Master's and Ph.D. theses from a small scientific community: case study of Croatian medical schools.

    Science.gov (United States)

    Frković, Vedran; Skender, Tomislav; Dojćinović, Bojan; Bilić-Zulle, Lidija

    2003-02-01

    To evaluate publishing activity of medical doctors after they have obtained Master's or Ph.D. degree at the Rijeka and Zagreb University Schools of Medicine in Croatia, and establish the number of journal articles based on these theses. Data on Master's and Ph.D. theses defended at the Rijeka and Zagreb University Schools of Medicine in the 1990-1999 period were collected by hand-search of the archive. MEDLINE and Current Contents databases were searched for journal articles resulting from the theses. During the 10-year period, 1,535 Master's and 634 Ph.D. theses were defended at the Rijeka and Zagreb University Schools of Medicine (253 Master's and 138 Ph.D. theses from Rijeka and 1,282 Master's and 496 Ph.D. theses from Zagreb). There were 201 (14%) Master's and 218 (34%) Ph.D. theses that resulted in articles published in journals indexed in MEDLINE (13% of Master's and 11% of Ph.D. theses from Rijeka, and 14% of Master's and 41% of Ph.D. theses from Zagreb). Also, 97 (6%) Master's and 129 (20%) Ph.D. theses that resulted in articles published in Current Contents journals (8% of Master's and 6% of Ph.D. theses from Rijeka, and 6% of Master's and 24% of Ph.D. theses from Zagreb). There was no significant difference between the two Universities with respect to published articles based on Master's theses, but there were significantly more articles from Ph.D. theses in Zagreb (ptheses resulted in a single publication (95%), 19 (5%) in 2, and 2 in 3 publications. Out of all 453 journal articles, 31% were published in Croatian and 69% in international journals. Most Croatian Master's and Ph.D. theses are not made available to the scientific community. There should be more institutional effort directed at the stimulation of postgraduate students to publish their scientific work.

  11. Mortality Risk from Co-Morbidities independent of Triple-Negative Breast Cancer Status: NCI SEER-based Cohort Analysis

    Science.gov (United States)

    Swede, Helen; Sarwar, Amna; Magge, Anil; Braithwaite, Dejana; Cook, Linda S.; Gregorio, David I.; Jones, Beth A; Hoag, Jessica; Gonsalves, Lou; Salner, Andrew; Zarfos, Kristen; Andemariam, Biree; Stevens, Richard G; Dugan, Alicia; Pensa, Mellisa; Brockmeyer, Jessica

    2017-01-01

    Purpose A comparatively high prevalence of co-morbidities among African-American/Blacks (AA/B) has been implicated in disparate survival in breast cancer. There is a scarcity of data, however, if this effect persists when accounting for the adverse triple-negative breast cancer (TNBC) subtype which occurs at three-fold the rate in AA/B compared to white breast cancer patients. Methods We reviewed charts of 214 white and 202 AA/B breast cancer patients in the NCI-SEER Connecticut Tumor Registry who were diagnosed in 2000-07. We employed the Charlson Co-Morbidity Index (CCI), a weighted 17-item tool to predict risk of death in cancer populations. Cox Survival Analyses estimated hazard ratios (HR) for all-cause mortality in relation to TNBC and CCI adjusting for clinicopathological factors. Results Among patients with SEER-Local Stage, TNBC increased the risk of death (HR=2.18, 95% CI 1.14-4.16), which was attenuated when the CCI score was added to the model (Adj. HR=1.50, 95% CI 0.74-3.01). Conversely, the adverse impact of the CCI score persisted when controlling for TNBC (Adj. HR=1.49, 95% CI 1.29-1.71; per one point increase). Similar patterns were observed in SEER-Regional Stage but estimated HRs were lower. AA/B patients with a CCI score of ≥3 had a significantly higher risk of death compared to AA/B patients without comorbidities (Adj. HR=5.65, 95% CI 2.90-11.02). A lower and non-significant effect was observed for whites with a CCI of ≥3 (Adj. HR=1.90, 95% CI 0.68-5.29). Conclusions Co-morbidities at diagnosis increase risk of death independent of TNBC, and AA/B patients may be disproportionately at risk. PMID:27000206

  12. Mortality risk from comorbidities independent of triple-negative breast cancer status: NCI-SEER-based cohort analysis.

    Science.gov (United States)

    Swede, Helen; Sarwar, Amna; Magge, Anil; Braithwaite, Dejana; Cook, Linda S; Gregorio, David I; Jones, Beth A; R Hoag, Jessica; Gonsalves, Lou; L Salner, Andrew; Zarfos, Kristen; Andemariam, Biree; Stevens, Richard G; G Dugan, Alicia; Pensa, Mellisa; A Brockmeyer, Jessica

    2016-05-01

    A comparatively high prevalence of comorbidities among African-American/Blacks (AA/B) has been implicated in disparate survival in breast cancer. There is a scarcity of data, however, if this effect persists when accounting for the adverse triple-negative breast cancer (TNBC) subtype which occurs at threefold the rate in AA/B compared to white breast cancer patients. We reviewed charts of 214 white and 202 AA/B breast cancer patients in the NCI-SEER Connecticut Tumor Registry who were diagnosed in 2000-2007. We employed the Charlson Co-Morbidity Index (CCI), a weighted 17-item tool to predict risk of death in cancer populations. Cox survival analyses estimated hazard ratios (HRs) for all-cause mortality in relation to TNBC and CCI adjusting for clinicopathological factors. Among patients with SEER local stage, TNBC increased the risk of death (HR 2.18, 95 % CI 1.14-4.16), which was attenuated when the CCI score was added to the model (Adj. HR 1.50, 95 % CI 0.74-3.01). Conversely, the adverse impact of the CCI score persisted when controlling for TNBC (Adj. HR 1.49, 95 % CI 1.29-1.71; per one point increase). Similar patterns were observed in SEER regional stage, but estimated HRs were lower. AA/B patients with a CCI score of ≥3 had a significantly higher risk of death compared to AA/B patients without comorbidities (Adj. HR 5.65, 95 % CI 2.90-11.02). A lower and nonsignificant effect was observed for whites with a CCI of ≥3 (Adj. HR 1.90, 95 % CI 0.68-5.29). comorbidities at diagnosis increase risk of death independent of TNBC, and AA/B patients may be disproportionately at risk.

  13. Identification of a radiosensitivity signature using integrative metaanalysis of published microarray data for NCI-60 cancer cells

    Directory of Open Access Journals (Sweden)

    Kim Han

    2012-07-01

    Full Text Available Abstract Background In the postgenome era, a prediction of response to treatment could lead to better dose selection for patients in radiotherapy. To identify a radiosensitive gene signature and elucidate related signaling pathways, four different microarray experiments were reanalyzed before radiotherapy. Results Radiosensitivity profiling data using clonogenic assay and gene expression profiling data from four published microarray platforms applied to NCI-60 cancer cell panel were used. The survival fraction at 2 Gy (SF2, range from 0 to 1 was calculated as a measure of radiosensitivity and a linear regression model was applied to identify genes or a gene set with a correlation between expression and radiosensitivity (SF2. Radiosensitivity signature genes were identified using significant analysis of microarrays (SAM and gene set analysis was performed using a global test using linear regression model. Using the radiation-related signaling pathway and identified genes, a genetic network was generated. According to SAM, 31 genes were identified as common to all the microarray platforms and therefore a common radiosensitivity signature. In gene set analysis, functions in the cell cycle, DNA replication, and cell junction, including adherence and gap junctions were related to radiosensitivity. The integrin, VEGF, MAPK, p53, JAK-STAT and Wnt signaling pathways were overrepresented in radiosensitivity. Significant genes including ACTN1, CCND1, HCLS1, ITGB5, PFN2, PTPRC, RAB13, and WAS, which are adhesion-related molecules that were identified by both SAM and gene set analysis, and showed interaction in the genetic network with the integrin signaling pathway. Conclusions Integration of four different microarray experiments and gene selection using gene set analysis discovered possible target genes and pathways relevant to radiosensitivity. Our results suggested that the identified genes are candidates for radiosensitivity biomarkers and that

  14. Breast cancer in women aging 35 years old and younger: The Egyptian National Cancer Institute (NCI) experience.

    Science.gov (United States)

    Darwish, A D; Helal, A M; Aly El-Din, N H; Solaiman, L L; Amin, A

    2017-02-01

    The aim is to identify the epidemiological and clinicopathological features associated with young breast cancer (BC) patients and to discuss factors affecting tumor recurrence and DFS. A retrospective analysis was conducted based on medical records from young females patients aged ≤35 years with pathologically confirmed primary breast cancer treated during 2008-2010 at NCI. Cases with non invasive cancer and non carcinoma histology are excluded. Of the 5408 cases diagnosed with breast cancer, 554 were young. Four hundred & fifty eight patients representing 9.2% were within our inclusion criteria. Almost half of the patients (45.9%) presented with stage III. Axillary nodes involvement was in 63.9%, 83.3% were grade 2. More than one quarter of tumors was hormone receptors negative (28.8%) & Her2 was over-expressed in 30%. Mastectomy was offered in 72% while conservative breast surgery in 26%, 69.2% received chemotherapy either adjuvant, neoadjuvant or both, 82.5% received adjuvant radiotherapy, 68.6% received hormonal therapy. Metastatic disease developed in 51.3%, with 31% having more than one site of metastases. After a median follow up period of 66 months, the median DFS of patients was 60 months. The median DFS was significantly shorter among patients with positive lymph nodes (P Breast cancer in young women is aggressive from the time of diagnosis. Our results provide baseline data of young BC in the Middle East & North Africa region; thus, contributing to future epidemiological and hospital-based researches. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Tendències de les publicacions informatives cientificomèdiques en l'era 2.0

    Directory of Open Access Journals (Sweden)

    González Pacanowski, Antonio

    2014-12-01

    Full Text Available En els últims anys ha crescut l'audiència que consulta continguts de salut en publicacions i mitjans a Internet, especialment a Europa i als Estats Units. S'ha passat d'un usuari d'Internet unidireccional en la comunicació a un escenari en el qual la multidireccionalitat i la instantaneïtat són constants. Els nous mitjans i la creació de plataformes d'intercanvi d'informació més especialitzada mostren que els recursos multimèdia i la interactivitat també poden donar-se en mitjans especialitzats i distants del públic general com ara informació sobre biomedicina i salut. Simultàniament, el canvi cap a actituds més solidàries i d'ajuda mútua aflora mitjançant les xarxes socials. Amb l'objectiu de traçar un escenari sobre el comportament de les audiències davant els continguts de caràcter científic, especialment els de tipus sanitari, s'analitzen en aquest treball els perfils i costums dels usuaris utilitzant referències estadístiques tant europees com nord-americanes. De la mateixa manera, s'identifica el mapa actual de cibermitjans relacionats amb la informació cientificomèdica segmentada en mitjans de comunicació generals, especialitzats i els propis del web 2.0, com ara blogs i mitjans cocreatius. Aquesta descripció permet orientar sobre les tendències que seguiran els públics diferents i segmentats, però ara interconnectats per les noves tecnologies, i sobre la transformació de l'arquitectura i les funcionalitats dels mitjans a Internet.En los últimos años ha crecido la audiencia que consulta contenidos de salud en publicaciones y medios en Internet, especialmente en Europa y Estados Unidos. Se ha pasado de un usuario de Internet unidireccional en la comunicación a un escenario en el que la multidireccionalidad y la instantaneidad son constantes. Los nuevos medios y la creación de plataformas de intercambio de información más especializada evidencian que los recursos multimedia y la interactividad tambi

  16. An interdepartmental Ph.D. program in computational biology and bioinformatics: the Yale perspective.

    Science.gov (United States)

    Gerstein, Mark; Greenbaum, Dov; Cheung, Kei; Miller, Perry L

    2007-02-01

    Computational biology and bioinformatics (CBB), the terms often used interchangeably, represent a rapidly evolving biological discipline. With the clear potential for discovery and innovation, and the need to deal with the deluge of biological data, many academic institutions are committing significant resources to develop CBB research and training programs. Yale formally established an interdepartmental Ph.D. program in CBB in May 2003. This paper describes Yale's program, discussing the scope of the field, the program's goals and curriculum, as well as a number of issues that arose in implementing the program. (Further updated information is available from the program's website, www.cbb.yale.edu.)

  17. Phd study of reliability and validity: One step closer to a standardized music therapy assessment model

    DEFF Research Database (Denmark)

    Jacobsen, Stine Lindahl

    The paper will present a phd study concerning reliability and validity of music therapy assessment model “Assessment of Parenting Competences” (APC) in the area of families with emotionally neglected children. This study had a multiple strategy design with a philosophical base of critical realism...... and pragmatism. The fixed design for this study was a between and within groups design in testing the APCs reliability and validity. The two different groups were parents with neglected children and parents with non-neglected children. The flexible design had a multiple case study strategy specifically...

  18. Synthesis of the PhD thesis "Anti-money laundering and counter terrorism financing management"

    Directory of Open Access Journals (Sweden)

    Camelia Popa

    2013-03-01

    Full Text Available As a whole, this PhD thesis follows three research lines, namely: (1 the conceptual line - concerns the definition of the money laundering and terrorism financing phenomenon, the processes, mechanisms, stages and instruments of the laundering of illegally obtained fund; (2 the estimative line aimed at measuring the size of money laundering phenomenon, the economic, social and security effects and consequences; (3 the line of an awareness of the need to prevent and fight against the effects arising from money laundering processes, the national and international efforts taken until present nation- and worldwide and the future measures required to diminish the consequences of this scourge.

  19. The first Italian doctorate (PhD Course) in Physics Education Research

    Science.gov (United States)

    Michelini, Marisa; Santi, Lorenzo

    2008-05-01

    The first PhD Italian course in Physics Education Research in Udine aims to qualify young researchers and teachers coming from all the Italian groups of research in the field. It becomes a context for developing research projects carried out following parallel research lines on: Teaching/Learning paths for didactic innovation, cognitive research, ICT for strategies to overcome conceptual knots in physics; E-learning for personalization; d) Computer on-line experiments and modelling; e) Teacher formation and training; f) Informal learning in science.

  20. The bachelor's to Ph.D. STEM pipeline no longer leaks more women than men: a 30-year analysis.

    Science.gov (United States)

    Miller, David I; Wai, Jonathan

    2015-01-01

    For decades, research and public discourse about gender and science have often assumed that women are more likely than men to "leak" from the science pipeline at multiple points after entering college. We used retrospective longitudinal methods to investigate how accurately this "leaky pipeline" metaphor has described the bachelor's to Ph.D. transition in science, technology, engineering, and mathematics (STEM) fields in the U.S. since the 1970s. Among STEM bachelor's degree earners in the 1970s and 1980s, women were less likely than men to later earn a STEM Ph.D. However, this gender difference closed in the 1990s. Qualitatively similar trends were found across STEM disciplines. The leaky pipeline metaphor therefore partially explains historical gender differences in the U.S., but no longer describes current gender differences in the bachelor's to Ph.D. transition in STEM. The results help constrain theories about women's underrepresentation in STEM. Overall, these results point to the need to understand gender differences at the bachelor's level and below to understand women's representation in STEM at the Ph.D. level and above. Consistent with trends at the bachelor's level, women's representation at the Ph.D. level has been recently declining for the first time in over 40 years.

  1. The NCI High Performance Computing (HPC) and High Performance Data (HPD) Platform to Support the Analysis of Petascale Environmental Data Collections

    Science.gov (United States)

    Evans, B. J. K.; Pugh, T.; Wyborn, L. A.; Porter, D.; Allen, C.; Smillie, J.; Antony, J.; Trenham, C.; Evans, B. J.; Beckett, D.; Erwin, T.; King, E.; Hodge, J.; Woodcock, R.; Fraser, R.; Lescinsky, D. T.

    2014-12-01

    The National Computational Infrastructure (NCI) has co-located a priority set of national data assets within a HPC research platform. This powerful in-situ computational platform has been created to help serve and analyse the massive amounts of data across the spectrum of environmental collections - in particular the climate, observational data and geoscientific domains. This paper examines the infrastructure, innovation and opportunity for this significant research platform. NCI currently manages nationally significant data collections (10+ PB) categorised as 1) earth system sciences, climate and weather model data assets and products, 2) earth and marine observations and products, 3) geosciences, 4) terrestrial ecosystem, 5) water management and hydrology, and 6) astronomy, social science and biosciences. The data is largely sourced from the NCI partners (who include the custodians of many of the national scientific records), major research communities, and collaborating overseas organisations. By co-locating these large valuable data assets, new opportunities have arisen by harmonising the data collections, making a powerful transdisciplinary research platformThe data is accessible within an integrated HPC-HPD environment - a 1.2 PFlop supercomputer (Raijin), a HPC class 3000 core OpenStack cloud system and several highly connected large scale and high-bandwidth Lustre filesystems. New scientific software, cloud-scale techniques, server-side visualisation and data services have been harnessed and integrated into the platform, so that analysis is performed seamlessly across the traditional boundaries of the underlying data domains. Characterisation of the techniques along with performance profiling ensures scalability of each software component, all of which can either be enhanced or replaced through future improvements. A Development-to-Operations (DevOps) framework has also been implemented to manage the scale of the software complexity alone. This ensures that

  2. Inactivated Tianjin strain, a novel genotype of Sendai virus, induces apoptosis in HeLa, NCI-H446 and Hep3B cells.

    Science.gov (United States)

    Chen, Jun; Han, Han; Wang, Bin; Shi, Liying

    2016-07-01

    The Sendai virus strain Tianjin is a novel genotype of the Sendai virus. In previous studies, ultraviolet-inactivated Sendai virus strain Tianjin (UV-Tianjin) demonstrated antitumor effects on human breast cancer cells. The aim of the present study was to investigate the in vitro antitumor effects of UV-Tianjin on the human cervical carcinoma HeLa, human small cell lung cancer NCI-H446 and human hepatocellular carcinoma Hep 3B cell lines, and the possible underlying mechanisms of these antitumor effects. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay revealed that UV-Tianjin treatment inhibited the proliferation of HeLa, NCI-H446 and Hep 3B cells in a dose- and time-dependent manner. Hoechst and Annexin V-fluorescein isothiocyanate/propidium iodide double staining indicated that UV-Tianjin induced dose-dependent apoptosis in all three cell lines with the most significant effect observed in the HeLa cell line. In the HeLa cell line, UV-Tianjin-induced apoptosis was further confirmed by the disruption of the mitochondria membrane potential and the activation of caspases, as demonstrated by fluorescent cationic dye and colorimetric assays, respectively. In addition, western blot analysis revealed that UV-Tianjin treatment resulted in significant upregulation of cytochrome c , apoptosis protease activating factor-1, Fas, Fas ligand and Fas-associated protein with death domain, and activated caspase-9, -8 and -3 in HeLa cells. Based on these results, it is hypothesized that UV-Tianjin exhibits anticancer activity in HeLa, NCI-H446 and Hep 3B cell lines via the induction of apoptosis. In conclusion, the results of the present study indicate that in the HeLa cell line, intrinsic and extrinsic apoptotic pathways may be involved in UV-Tianjin-induced apoptosis.

  3. Systematic analysis and comparison of the PHD-Finger gene family in Chinese pear (Pyrus bretschneideri) and its role in fruit development.

    Science.gov (United States)

    Cao, Yunpeng; Han, Yahui; Meng, Dandan; Abdullah, Muhammad; Li, Dahui; Jin, Qing; Lin, Yi; Cai, Yongping

    2018-04-20

    PHD-finger proteins, which belongs to the type of zinc finger family, and that play an important role in the regulation of both transcription and the chromatin state in eukaryotes. Currently, PHD-finger proteins have been well studied in animals, while few studies have been carried out on their function in plants. In the present study, 129 non-redundant PHD-finger genes were identified from 5 Rosaceae species (pear, apple, strawberry, mei, and peach); among them, 31 genes were identified in pear. Subsequently, we carried out a bioinformatics analysis of the PHD-finger genes. Thirty-one PbPHD genes were divided into 7 subfamilies based on the phylogenetic analysis, which are consistent with the intron-exon and conserved motif analyses. In addition, we identified five segmental duplication events, implying that the segmental duplications might be a crucial role in the expansion of the PHD-finger gene family in pear. The microsynteny analysis of five Rosaceae species showed that there were independent duplication events in addition to the genome-wide duplication of the pear genome. Subsequently, ten expressed PHD-finger genes of pear fruit were identified using qRT-PCR, and one of these genes, PbPHD10, was identified as an important candidate gene for the regulation of lignin synthesis. Our research provides useful information for the further analysis of the function of PHD-finger gene family in pear.

  4. An Analysis of Gender Differences in Recent Earth and Space Science PhD Graduates

    Science.gov (United States)

    Giesler, J.

    2001-12-01

    The American Geophysical Union (AGU) and the American Geological Institute (AGI) have been collecting data on recent PhDs in the geosciences for 5 years (1996-2000). The 1999-2000 PhD classes were combined for an increased sample size and analyzed for gender differences. Other than salary, place of employment, and job search methodology no differences were found. Females had salaries that were slightly lower than those of their male counterparts. This might be due to the fact that there are a greater number of female postdoctoral candidates 47% compared to males 40%. Place of employment tended to be similar with fewer women in industry and a higher number of recent female PhD graduates in the academic sector. Interestingly, men and women differed in the ways in which they found their first job. A higher percent of men reported they felt their advisor was helpful in their job search (52% for men and 50% for women). Women used electronic resources at a higher rate (17.3%) than men (12.1%) and 33.6% of the women felt their scientific society was helpful in their job search, compared to only 24.1% of the men.

  5. Pharmacoeconomics and outcomes research degree-granting PhD programs in the United States.

    Science.gov (United States)

    Slejko, Julia F; Libby, Anne M; Nair, Kavita V; Valuck, Robert J; Campbell, Jonathan D

    2013-01-01

    Evidence is missing on showcasing current practices of degree programs specific to the field of pharmaceutical outcomes research. To measure current practices of pharmacoeconomics and outcomes research PhD programs in the United States and synthesize recommendations for improving the success of programs and prospective students. A 23-question online survey instrument was created and distributed to 32 program directors identified in the International Society for Pharmacoeconomics and Outcomes Research educational directory. Descriptive statistics summarized both the program characteristics (including observed and desired number of faculty and students) and training recommendations (traits of program and student success). Of 30 eligible programs that conferred a PhD in pharmacoeconomics, pharmaceutical outcomes research, or a related field, 16 respondents (53%) completed the survey. Seventy-five percent of respondents were located in a school of pharmacy. The average observed number of faculty (7.5) and students (11.5) was lower than the average desired numbers (8.1) and (14.7), respectively. Reputation of faculty research and a collaborative environment with other disciplines were rated highest for a program's success. Faculty's mentoring experience and reputation and student funding opportunities were rated highest for prospective students' success. Existing and emerging programs as well as prospective students can use these findings to further their chances of success. Copyright © 2013 Elsevier Inc. All rights reserved.

  6. [PhD theses on gerontological topics in Russia 1995-2012: scientometric analysis].

    Science.gov (United States)

    Smol'kin, A A; Makarova, E A

    2014-01-01

    The paper presents a scientometric analysis of PhD theses on gerontological topics in Russian humanities (excluding economics) for the period from 1995 to 2012. During this period, 253 PhD theses (238 of "candidate dissertations," and 15 of "doctoral dissertations") were defended in Russia. Almost half of them were defended during the boom years (2005-2006; 2009-2010). The number of theses defended in the 2000-s has increased significantly compared to the second half of 1990-s. However for gerontological PhD-s overall as a percentage of all theses defended in Russian humanities, the number hardly changed and remained small (less than 0.3%). The leading discipline in the study of aging (within the humanities) is sociology accounting for more than a third of all defended theses. Though the theses were defended in 48 cities, more than half of them were defended in 3 cities, which are Moscow, St. Petersburg and Saratov. Thematic analysis showed that the leading position was occupied by two topics: "the elderly and the state" (42%) and "(re)socialization/adaptation of the elderly" (25%). 14% of the works are devoted to intergenerational relations and social status of the elderly. Other topics (old man/woman's personality, self-perceptions of aging, violence and crime against the elderly, loneliness, discrimination, etc.) are presented by very few studies.

  7. Next gen PhD a guide to career paths in science

    CERN Document Server

    Sinche, Melanie V

    2016-01-01

    For decades, top scientists in colleges and universities pursued a clear path to success: enroll in a prestigious graduate program, conduct research, publish papers, complete the PhD, pursue postdoctoral work. With perseverance and a bit of luck, a tenure-track professorship awaited at the end. In today s academic job market, this scenario represents the exception. As the number of newly conferred science PhDs keeps rising, the number of tenured professorships remains stubbornly stagnant. Only 14 percent of those with PhDs in science occupy tenure-track positions five years after completing their degree. Next Gen PhD provides a frank and up-to-date assessment of the current career landscape facing science PhDs. Nonfaculty careers once considered Plan B are now preferred by the majority of degree holders, says Melanie Sinche. An upper-level science degree is a prized asset in the eyes of many employers, and a majority of science PhDs build rewarding careers both inside and outside the university. A certified ...

  8. First ‘Gentner Doktor’ finishes PhD at CERN

    CERN Multimedia

    Jordan Juras

    2011-01-01

    In 2007, the CERN Doctoral Student Programme saw the addition of the Gentner Doctoral Student Programme, named in honour of the celebrated nuclear physicist, Wolfgang Gentner. Four years later, on 22 June 2011, Marcel Schuh finished his PhD with a thesis in the field of accelerator technology and became the very first ‘Gentner Doktor’.   Marcel Schuh, first 'Gentner Doktor', celebrates completing his PhD. (Photo by Carsten P. Welsch) Marcel Schuh became a Gentner student in April 2008, after completing a physics degree in 2007 at the University of Heidelberg. His thesis allowed him to gain exposure to CERN and the LHC, as he worked on monitoring and control systems for trigger and readout electronics on the ALICE detector at the LHC. With the support of university supervisor, Carsten P. Welsch, Schuh applied for a Gentner Doctoral Studentship on the Superconducting Proton Linac (SPL) project. “My task was to evaluate whether dedicated higher order mode (HOM) coupler...

  9. Empirical Essays on the Labor Market Outcomes of PhD Graduates

    DEFF Research Database (Denmark)

    Pedersen, Heidi Skovgaard

    that PhDs accelerate growth. A major objective has been to direct more PhDs to the industry to use their skills to monetize knowledge. However, we have limited evidence on how PhDs are absorbed into the labor market, how the market values PhD labor, and how PhDs value the possibility to work......During the past decade, policy makers have accentuated the need for more PhDs to drive innovation and use their research skills to push the technological frontier. The public sector in Denmark has financially supported a doubling of the number of enrolled PhD students based on a strong belief...... in the private sector. The dissertation investigates determinants of labor market decisions among recent cohorts of PhDs in Denmark to assess how the increasing number of PhDs is absorbed into the economy. Based on econometric models, it examines what factors trigger individual career decisions and supply...

  10. Internationalization Impact on PhD Training Policy in Russia: Insights from The Comparative Document Analysis

    Directory of Open Access Journals (Sweden)

    Oksana Chigisheva

    2017-09-01

    Full Text Available The relevance of the study is due to the need for an objective picture of the Russian third level tertiary education transformation driven by internationalization issues and global trends in education. The article provides an analytical comparative review of the official documents related to the main phases of education reform in Russia and focuses on the system of PhD training which has undergone significant reorganization in recent years. A series of alterations introduced into the theory and practice of postgraduate education in Russia are traced in regulatory documents and interpreted in terms of growing internationalization demand. Possible implications for further development of the research human potential in Russia are being discussed. The method of comparative document analysis produces the best possible insight into the subject. The findings of the study contribute to the understanding of current challenges facing the system of doctoral studies in Russia and lead to certain conclusions on the transformation of educational policy in relation to PhD training under the influence of internationalization agenda.

  11. Variations in Mre11/Rad50/Nbs1 status and DNA damage-induced S-phase arrest in the cell lines of the NCI60 panel

    Directory of Open Access Journals (Sweden)

    Eastman Alan

    2011-05-01

    Full Text Available Abstract Background The Mre11/Rad50/Nbs1 (MRN complex is a regulator of cell cycle checkpoints and DNA repair. Defects in MRN can lead to defective S-phase arrest when cells are damaged. Such defects may elicit sensitivity to selected drugs providing a chemical synthetic lethal interaction that could be used to target therapy to tumors with these defects. The goal of this study was to identify these defects in the NCI60 panel of cell lines and identify compounds that might elicit selective cytotoxicity. Methods We screened the NCI60 panel in search of cell lines that express low levels of MRN proteins, or that fail to arrest in S-phase in response to the topisomerase I inhibitor SN38. The NCI COMPARE program was used to discover compounds that preferentially target cells with these phenotypes. Results HCT116 cells were initially identified as defective in MRN and S phase arrest. Transfection with Mre11 also elevated Rad50 and Nbs1, and rescued the defective S-phase arrest. Cells of the NCI60 panel exhibited a large range of protein expression but a strong correlation existed between Mre11, Rad50 and Nbs1 consistent with complex formation determining protein stability. Mre11 mRNA correlated best with protein level suggesting it was the primary determinant of the overall level of the complex. Three other cell lines failed to arrest in response to SN38, two of which also had low MRN. However, other cell lines with low MRN still arrested suggesting low MRN does not predict an inability to arrest. Many compounds, including a family of benzothiazoles, correlated with the failure to arrest in S phase. The activity of benzothiazoles has been attributed to metabolic activation and DNA alkylation, but we note several cell lines in which sensitivity does not correlate with metabolism. We propose that the checkpoint defect imposes an additional mechanism of sensitivity on cells. Conclusions We have identified cells with possible defects in the MRN complex

  12. Evaluation of the UF/NCI hybrid computational phantoms for use in organ dosimetry of pediatric patients undergoing fluoroscopically guided cardiac procedures

    Science.gov (United States)

    Marshall, Emily L.; Borrego, David; Tran, Trung; Fudge, James C.; Bolch, Wesley E.

    2018-03-01

    Epidemiologic data demonstrate that pediatric patients face a higher relative risk of radiation induced cancers than their adult counterparts at equivalent exposures. Infants and children with congenital heart defects are a critical patient population exposed to ionizing radiation during life-saving procedures. These patients will likely incur numerous procedures throughout their lifespan, each time increasing their cumulative radiation absorbed dose. As continued improvements in long-term prognosis of congenital heart defect patients is achieved, a better understanding of organ radiation dose following treatment becomes increasingly vital. Dosimetry of these patients can be accomplished using Monte Carlo radiation transport simulations, coupled with modern anatomical patient models. The aim of this study was to evaluate the performance of the University of Florida/National Cancer Institute (UF/NCI) pediatric hybrid computational phantom library for organ dose assessment of patients that have undergone fluoroscopically guided cardiac catheterizations. In this study, two types of simulations were modeled. A dose assessment was performed on 29 patient-specific voxel phantoms (taken as representing the patient’s true anatomy), height/weight-matched hybrid library phantoms, and age-matched reference phantoms. Two exposure studies were conducted for each phantom type. First, a parametric study was constructed by the attending pediatric interventional cardiologist at the University of Florida to model the range of parameters seen clinically. Second, four clinical cardiac procedures were simulated based upon internal logfiles captured by a Toshiba Infinix-i Cardiac Bi-Plane fluoroscopic unit. Performance of the phantom library was quantified by computing both the percent difference in individual organ doses, as well as the organ dose root mean square values for overall phantom assessment between the matched phantoms (UF/NCI library or reference) and the patient

  13. Competències i factors clau per a l’èxit educatiu des de la perspectiva dels estudiants universitaris fills/es dels immigrants

    OpenAIRE

    Cano García, Elena

    2013-01-01

    L’estudi realitzat ha abordat quines són les competències i els factors clau que estudiants universitaris d’origen immigrant consideren que han estat claus per arribar a la universitat, assolint així l’èxit educatiu. S’han escollit estudiants que haguessin fet l’escolaritat obligatòria total o parcialment a Catalunya.Per dur a terme la recerca s’ha treballat amb relats de vida (un total de 13 escrits) i narracions audiovisuals (amb un total de 4 produccions), essent finalment 17 les evidèncie...

  14. Variations in Mre11/Rad50/Nbs1 status and DNA damage-induced S-phase arrest in the cell lines of the NCI60 panel

    International Nuclear Information System (INIS)

    Garner, Kristen M; Eastman, Alan

    2011-01-01

    The Mre11/Rad50/Nbs1 (MRN) complex is a regulator of cell cycle checkpoints and DNA repair. Defects in MRN can lead to defective S-phase arrest when cells are damaged. Such defects may elicit sensitivity to selected drugs providing a chemical synthetic lethal interaction that could be used to target therapy to tumors with these defects. The goal of this study was to identify these defects in the NCI60 panel of cell lines and identify compounds that might elicit selective cytotoxicity. We screened the NCI60 panel in search of cell lines that express low levels of MRN proteins, or that fail to arrest in S-phase in response to the topisomerase I inhibitor SN38. The NCI COMPARE program was used to discover compounds that preferentially target cells with these phenotypes. HCT116 cells were initially identified as defective in MRN and S phase arrest. Transfection with Mre11 also elevated Rad50 and Nbs1, and rescued the defective S-phase arrest. Cells of the NCI60 panel exhibited a large range of protein expression but a strong correlation existed between Mre11, Rad50 and Nbs1 consistent with complex formation determining protein stability. Mre11 mRNA correlated best with protein level suggesting it was the primary determinant of the overall level of the complex. Three other cell lines failed to arrest in response to SN38, two of which also had low MRN. However, other cell lines with low MRN still arrested suggesting low MRN does not predict an inability to arrest. Many compounds, including a family of benzothiazoles, correlated with the failure to arrest in S phase. The activity of benzothiazoles has been attributed to metabolic activation and DNA alkylation, but we note several cell lines in which sensitivity does not correlate with metabolism. We propose that the checkpoint defect imposes an additional mechanism of sensitivity on cells. We have identified cells with possible defects in the MRN complex and S phase arrest, and a series of compounds that may

  15. Incidència i consequències de les caigudes en les persones grans que viuen a la comunitat

    OpenAIRE

    Salvà, Antoni

    2016-01-01

    ANTECEDENTS I OBJECTIUS: Avaluar la incidència de les caigudes en funció dels factors sociodemogràfics i de salut, i determinar llurs conseqüències físiques, psicològiques i socials. Desenvolupar una nova eina d'avaluació del factor de risc amb l'objectiu d'assolir una intervenció preventiva multifactorial. METODOLOGIA: Estudi poblacional prospectiu, que inclou una cohort representativa de 448 persones grans, de 65 anys o més, que viuen a la ciutat de Mataró (Espanya). Hem fet una avaluació b...

  16. The utilization of websites for fundraising by NCI-designated cancer centers: Examining the capacity for dialogic communication with prospective donors.

    Science.gov (United States)

    Erwin, Cathleen O; Dias, Ashley M

    2016-01-01

    The study employs a dialogic public relations framework to explore the utilization of the Internet for fundraising by nonprofit health care organizations-specifically, NCI-designated cancer centers. Cancer centers have been noted for effective websites and for being highly engaged in fundraising, which is characterized as relationship marketing. Results indicate all but one cancer center use websites and social media for fundraising but are limited in capacity for two-way symmetrical dialogue. Results are discussed and recommendations are made for future research.

  17. COMPARISON OF RESEARCH ENGAGEMENT OF PHD STUDENTS AT VARIOUS STUDY PROGRAMS AT CULS PRAGUE: AN INTRODUCTORY STUDY

    Directory of Open Access Journals (Sweden)

    FLÉGL, Martin

    2014-12-01

    Full Text Available In an attempt to improve the quality of doctoral studies and the satisfaction of PhD students at the Czech University of Life Sciences Prague (CULS Prague the authors disseminated online questionnaire among all PhD students in May and June 2014. The questionnaire covered areas related to doctoral study, PhD supervisors, doctoral scholarship, research publications, and last but not least, to satisfaction with the doctoral study. In this article responses related to research, such as allocation of time to doctoral studies, allocation of time to research, involvement in research projects and satisfaction with research outputs. The authors provide comparison of all above mentioned domains according to faculties as well as form of doctoral studies at CULS Prague.

  18. Short Hairpin RNA Silencing of PHD-2 Improves Neovascularization and Functional Outcomes in Diabetic Wounds and Ischemic Limbs.

    Directory of Open Access Journals (Sweden)

    Kevin J Paik

    Full Text Available The transcription factor hypoxia-inducible factor 1-alpha (HIF-1α is responsible for the downstream expression of over 60 genes that regulate cell survival and metabolism in hypoxic conditions as well as those that enhance angiogenesis to alleviate hypoxia. However, under normoxic conditions, HIF-1α is hydroxylated by prolyl hydroxylase 2, and subsequently degraded, with a biological half-life of less than five minutes. Here we investigated the therapeutic potential of inhibiting HIF-1α degradation through short hairpin RNA silencing of PHD-2 in the setting of diabetic wounds and limb ischemia. Treatment of diabetic mouse fibroblasts with shPHD-2 in vitro resulted in decreased levels of PHD-2 transcript demonstrated by qRT-PCR, higher levels of HIF-1α as measured by western blot, and higher expression of the downstream angiogenic genes SDF-1 and VEGFα, as measured by qRT-PCR. In vivo, shPHD-2 accelerated healing of full thickness excisional wounds in diabetic mice compared to shScr control, (14.33 ± 0.45 days vs. 19 ± 0.33 days and was associated with an increased vascular density. Delivery of shPHD-2 also resulted in improved perfusion of ischemic hind limbs compared to shScr, prevention of distal digit tip necrosis, and increased survival of muscle tissue. Knockdown of PHD-2 through shRNA treatment has the potential to stimulate angiogenesis through overexpression of HIF-1α and upregulation of pro-angiogenic genes downstream of HIF-1α, and may represent a viable, non-viral approach to gene therapy for ischemia related applications.

  19. The Road to Become a Legitimate Scholar: A Case Study of International PhD Students in Science and Engineering

    Directory of Open Access Journals (Sweden)

    Pia Bøgelund

    2015-11-01

    Full Text Available The purpose of the doctoral education process is to create and legitimize scholarly researchers. This transformation, from student to scholar, is widely discussed in the literature. However, recent rapid changes in university culture have resulted in less time for supervision, stricter completion deadlines, and a greater focus on efficiency and productivity. This has had an impact on this transition process, and this impact has not been widely studied. The aim of this article is to understand the consequences of the current trends for PhD students and the education of PhD students in general. The article is based on interviews with 14 international students from two different research programs at the Faculty of Engineering and Science at Aalborg University in Denmark. The case of international PhD students in a western setting is singled out as a challenging case for becoming a legitimate scholar, since they face the additional challenge of becoming socialised into their new foreign setting. Overall, the study concludes that the transition process of doctoral students is affected by the way different supervisors deal with current university trends and how PhD students fit or do not fit into their knowledge production practices. The study identifies matches or mismatches in a knowledge production perspective, quality of contact, and degree of independence of the PhD student as factors that influence whether a transition process can be marked as sound, troublesome, or lacking. Finally, the study identifies an overall risk of neglecting the more interdependent types of international PhD students. Suggestions are given as how to address this risk.

  20. NCI Precision Medicine

    Science.gov (United States)

    This illustration represents the National Cancer Institute’s support of research to improve precision medicine in cancer treatment, in which unique therapies treat an individual’s cancer based on specific genetic abnormalities of that person’s tumor.

  1. Emerging areas of nursing science and PhD education for the 21(st) century: response to commentaries.

    Science.gov (United States)

    Henly, Susan J; McCarthy, Donna O; Wyman, Jean F; Alt-White, Anna C; Stone, Patricia W; McCarthy, Ann Marie; Redeker, Nancy S; Dunbar-Jacob, Jacqueline; Titler, Marita G; Conley, Yvette P; Heitkemper, Margaret M; Moore, Shirley M

    2015-01-01

    We respond to commentaries from the American Academy of Nursing, the American Association of Colleges of Nursing, and the National Institute of Nursing Research on our thoughts about integrating emerging areas of science into nursing PhD programs. We identify areas of agreement and focus our response on cross-cutting issues arising from cautions about the unique focus of nursing science and how best to proceed with incorporation of emerging areas of science into nursing PhD programs. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. Customizing Process to Align with Purpose and Program: The 2003 MS PHD'S in Ocean Sciences Program Evaluative Case Study

    Science.gov (United States)

    Williamson, V. A.; Pyrtle, A. J.

    2004-12-01

    How did the 2003 Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S) in Ocean Sciences Program customize evaluative methodology and instruments to align with program goals and processes? How is data captured to document cognitive and affective impact? How are words and numbers utilized to accurately illustrate programmatic outcomes? How is compliance with implicit and explicit funding regulations demonstrated? The 2003 MS PHD'S in Ocean Sciences Program case study provides insightful responses to each of these questions. MS PHD'S was developed by and for underrepresented minorities to facilitate increased and sustained participation in Earth system science. Key components of this initiative include development of a community of scholars sustained by face-to-face and virtual mentoring partnerships; establishment of networking activities between and among undergraduate, graduate, postgraduate students, scientists, faculty, professional organization representatives, and federal program officers; and provision of forums to address real world issues as identified by each constituent group. The evaluative case study of the 2003 MS PHD'S in Ocean Sciences Program consists of an analysis of four data sets. Each data set was aligned to document progress in the achievement of the following program goals: Goal 1: The MS PHD'S Ocean Sciences Program will successfully market, recruit, select, and engage underrepresented student and non-student participants with interest/ involvement in Ocean Sciences; Goal 2: The MS PHD'S Ocean Sciences Program will provide meaningful engagement for participants as determined by quantitative analysis of user-feedback; Goal 3: The MS PHD'S Ocean Sciences Program will provide meaningful engagement for participants as determined by qualitative analysis of user-feedback, and; Goal 4: The MS PHD'S Ocean Sciences Program will develop a constituent base adequate to demonstrate evidence of interest, value, need and sustainability in

  3. The Market for Ph.D. Holders in Greece: Probit and Multinomial Logit Analysis of their Employment Status

    OpenAIRE

    Joan Daouli; Eirini Konstantina Nikolatou

    2015-01-01

    The objective of this paper is to investigate the factors influencing the probability that a Ph.D. holder in Greece will work in the academic sector, as well as the probability of his or her choosing employment in various sectors of industry and occupational categories. Probit/multinomial logit models are employed using the 2001 Census data. The empirical results indicate that being young, married, having a Ph.D. in Natural Sciences and/or in Engineering, granted by a Greek university, increa...

  4. La colección ibero-balear de Meloidae Gyllenhal, 1810 (Coleoptera, Tenebrionoidea del Museu de Ciències Naturals de Barcelona

    Directory of Open Access Journals (Sweden)

    Prieto, M.

    2016-12-01

    Full Text Available The Ibero-Balearic collection of Meloidae Gyllenhal, 1810 (Coleoptera, Tenebrionoidea of the Museu de Ciències Naturals de Barcelona A commented catalogue of the Ibero-Balearic collection of Meloidae Gyllenhal, 1810 housed in the Museu de Ciències Naturals de Barcelona is presented. The studied material consists of 2,129 specimens belonging to 49 of 64 species from the Iberian peninsula and the Balearic Islands. The temporal coverage of the collection extends from the last decades of the nineteenth century to the present time. Revision, documentation, and computerization of the material have been made, resulting in 963 collection records (June 2014. For each lot, the catalogue includes the register number, geographical data, collection date, collector or origin of the collection, and number of specimens. Information about taxonomy and distribution of the species is also given. Chorological novelties are provided, extending the distribution areas for most species. The importance of the collection for the knowledge of the Ibero-Balearic fauna of Meloidae is discussed, particularly concerning the area of Catalonia (northeastern Iberian peninsula as it accounts for 60% of the records. Some rare or particularly interesting species in the collection are highlighted, as are those requiring protection measures in Spain and Catalonia. The catalogue also shows a brief gallery of photographs that includes four type specimens.

  5. El procés d'avaluació i intervenció psicològica a pacients amb trastorns per abús d' alcohol i/o altres substàncies psicotròpiques

    OpenAIRE

    Trasovares Navarrete, María Victoria

    2004-01-01

    Aquest treball, realitzat al Centre d'Atenció i Seguiment de Drogodependències (CASD) de Nou Barris, ha tingut com a objectiu principal observar el rol del psicòleg clínic en el procés d'avaluació i intervenció psicoterapèutica en pacients que presenten un trastorn per dependència de substàncies psicotròpiques. Este trabajo, realizado en el Centro de Atención y Seguimiento de Drogodependencias (CASD) de Nou Barris, ha tenido como principal objetivo observar el rol del psicólogo clínico en ...

  6. Researcher Profile: An Interview with John E. Grable, Ph.D., CFP(R

    Directory of Open Access Journals (Sweden)

    John Grable

    2014-08-01

    Full Text Available John E. Grable, Ph.D., CFP(R teaches and conducts research in the Certified Financial Planner(TM Board of Standards undergraduate and graduate programs at the University of Georgia. Prior to entering the academic profession, he worked as a pension/benefits administrator and later as a Registered Investment Advisor in an asset management firm. He served as the founding editor for the Journal of Personal Finance and as the co-founding editor of the Journal of Financial Therapy. His research interests include financial risk-tolerance assessment, psychophysiological economics, and financial planning help-seeking behavior. Dr. Grable has published nearly 100 peer-reviewed papers, co-authored two financial planning textbooks, and co-edited a financial planning and counseling scales book. He currently writes a quarterly column for the Journal of Financial Service Professionals, serves as academic consultant to the Journal of Financial Planning, and chair the CFP Board Council on Education.

  7. Sample Size and Saturation in PhD Studies Using Qualitative Interviews

    Directory of Open Access Journals (Sweden)

    Mark Mason

    2010-08-01

    Full Text Available A number of issues can affect sample size in qualitative research; however, the guiding principle should be the concept of saturation. This has been explored in detail by a number of authors but is still hotly debated, and some say little understood. A sample of PhD studies using qualitative approaches, and qualitative interviews as the method of data collection was taken from theses.com and contents analysed for their sample sizes. Five hundred and sixty studies were identified that fitted the inclusion criteria. Results showed that the mean sample size was 31; however, the distribution was non-random, with a statistically significant proportion of studies, presenting sample sizes that were multiples of ten. These results are discussed in relation to saturation. They suggest a pre-meditated approach that is not wholly congruent with the principles of qualitative research. URN: urn:nbn:de:0114-fqs100387

  8. Researcher Profile: An Interview with Virginia Solis Zuiker, Ph.D.

    Directory of Open Access Journals (Sweden)

    Virginia Solis Zuiker

    2015-12-01

    Full Text Available Virginia Solis Zuiker is an Associate Professor in the Department of Family Social Science at the University of Minnesota. She teaches courses on personal and family finance, family financial counseling, family resource management, economic perspectives of families, and family decision-making. Her scholarly research focus is in the area of economic well-being of families with particular interest in self-employment and family-owned businesses. Her research focuses on the Hispanic family life and she is the author of “Hispanic Self-Employment in the Southwest: Rising Above the Threshold of Poverty,” (Garland Publishing, 1997. She received her B.S. from the University of North Texas, an M.S. from Texas Tech University, and a Ph.D. from The Ohio State University. She served three years on the Board of Directors for the Association of Financial Counseling and Planning Education.

  9. Researcher Profile: An Interview with Sonya Britt, Ph.D., CFP, AFC

    Directory of Open Access Journals (Sweden)

    Sonya Britt

    2013-08-01

    Full Text Available Sonya Britt, Ph.D., CFP, AFC graduated from Texas Tech University in 2010 with a doctorate in Personal Financial Planning. Her first two degrees are from Kansas State University in Personal Financial Planning (B.S. and Marriage and Family Therapy (M.S.. and she was the founding president of the Financial Therapy Association and recently retired from the board as past-president. She currently serves on the board of the American Council on Consumer Interests association. Sonya is an associate editor for the Journal of Family and Economic Issues and on the editorial board of the Journal of Financial Therapy and on the international scientific board of the Italian Journal of Sociology of Education.

  10. Investigator profile. An interview with Salvador Contreras Balderas, Ph.D. Interview by Vicki Glaser.

    Science.gov (United States)

    Contreras Balderas, Salvador

    2006-01-01

    Dr. Contreras Balderas is Professor Emeritus in the Department of Biology at Universidad Autonoma de Nuevo Leon (Monterrey, Mexico). He received a Master's degree and Ph.D. in Biological Sciences from Tulane University (New Orleans, LA) and wrote his dissertation on Ichthyology. He was awarded the President's Excellence Award of the American Fisheries Society. Dr. Contreras Balderas is Founder, President, and Honorary Member of the Mexican Society of Zoology, the Ichthyological Society of Mexico, and the Desert Fishes Council, is an ex-officio member of the Coalition for the Sustainable Development of the Rio Grande/Rio Bravo, U.S. & Mexico, and is a member of the U.S. Fish and Wildlife's Rio Grande Fishes Recovery Team. Dr. Contreras Balderas's areas of expertise include fish faunas, fishes at risk, exotic species, aquatic restoration, environmental impacts as detected by fishes, integral conservation, integral basin/ecosystem management, and ecological evaluation of integrity in basins.

  11. Instructors of psychotherapy in M.A. and Ph.D. clinical programs.

    Science.gov (United States)

    Stevens, H B

    1996-08-01

    The present study investigated the characteristics and orientations of the instructors of the initial psychotherapy course of the 44 members and affiliates of the Council of Applied Master's Programs in Psychology. Also examined were the focus of instruction in the course and the teachers' style of instruction. Responses for 26 completed surveys (58%) were compared with responses from instructors of initial psychotherapy courses in 69 of the 170 APA accredited doctoral programs. Five general theoretical orientations were represented by the M.A. instructors with 28% self-identifying as humanistic, 24% as dynamic, 20% as cognitive behavioral, 16% as interpersonal, and 12% as behavioral. No significant differences were found on demographic characteristics, theoretical orientation, focus of instruction, or method of instruction between instructors in M.A. and those in Ph.D. programs.

  12. Do PhD supervisors play a role in bridging academic cultures?

    DEFF Research Database (Denmark)

    Elliot, Dely; Kobayashi, Sofie

    Our study reports a phenomenological investigation of ten international PhD students’ and nine supervisors’ first-hand experience of being in doctoral supervisory relationships in a Danish setting. In-depth qualitative data were gathered through face-to-face individual interviews, which explored...... differences and challenges experienced as a result of diversity with respect to their educational background and practices, particularly the pedagogic variation. In the same way that the literature suggests that educators play a crucial role in mediating such diversity in the teaching and learning contexts...... relationship (that crosses over academic and non-academic concerns) and the distinct role it plays deserves further attention. Cotterall, S. (2013). More than just a brain: emotions and the doctoral experience. Higher Education Research & Development, 1-14. Wright, T. (2003). Postgraduate research students...

  13. Are MS in Economics Programs in Departments That Also Have a PhD Program in Economics Different from Their Counterparts?

    Science.gov (United States)

    Milkman, Martin I.; Marjadi, Riza; McCoy, James P.

    2016-01-01

    This is the first article that compares terminal master's degree programs in economics from universities that have a PhD program in economics with those that do not offer PhD programs in economics. The authors compare these differences based on surveys in 2002 and 2012. They examine differences in general program characteristics, department…

  14. Determinants of the Job Satisfaction of PhD Holders: An Analysis by Gender, Employment Sector, and Type of Satisfaction in Spain

    Science.gov (United States)

    Escardíbul, Josep-Oriol; Afcha, Sergio

    2017-01-01

    We analyze the determinants of job satisfaction of PhD holders in Spain. Specifically, we consider overall job satisfaction as well as basic and motivational satisfaction, following Herzberg's typology (based on Maslow's hierarchy of needs). Using representative data for Spain's PhD population--collected from the Spanish Survey on Human Resources…

  15. Serving Many Masters: The PhD on the Labour Market, the Everlasting Need of Inequality, and the Premature Death of Humboldt.

    Science.gov (United States)

    Enders, Jurgen

    2002-01-01

    Surveyed German doctoral degree holders to examine the processes and outcomes of doctoral training and their impact on subsequent careers and work affiliations. Found a positive outcome of the Ph.D. on the labor market, and that selection for doctoral training is biased by social origin while later career attainment among Ph.D. holders is not. (EV)

  16. What Matters for Excellence in PhD Programs? Latent Constructs of Doctoral Program Quality Used by Early Career Social Scientists

    Science.gov (United States)

    Morrison, Emory; Rudd, Elizabeth; Zumeta, William; Nerad, Maresi

    2011-01-01

    This paper unpacks how social science doctorate-holders come to evaluate overall excellence in their PhD training programs based on their domain-specific assessments of aspects of their programs. Latent class analysis reveals that social scientists 6-10 years beyond their PhD evaluate the quality of their doctoral program with one of two…

  17. Factors Influencing the Degree Progress of International PhD Students from Africa: An Exploratory Study

    Directory of Open Access Journals (Sweden)

    Almoustapha Oumarou Soumana

    2017-05-01

    Full Text Available In recent decades some countries of the Middle East have offered facilities to attract international students to pursue their higher education within their higher education institutions. The purpose of this study is to understand the difficulties faced by these students while conducting their studies abroad, and in doing so, to broaden the awareness of the challenges they face to complete their research. The participants of this qualitative study are international PhD students studying at a Middle Eastern public university. The university has reported increasing enrollment of international students, particularly from Africa in the last few years. Data were collected using a set of semi-structured interviews that drew out information on critical incidents that characterized the kind of difficulties students had faced in their studies. The data collected was further analyzed using a qualitative software package, NVivo (QSR International, 11. Six main themes came out from the content analysis of the interviews, which are the role of the adviser, student features, funding issues, family engagement, research and psychological obstacles which provide a holistic picture of student perspectives on the factors that influence degree progress. While these students might have faced difficulties mentioned in existing literature, this study argues that the participants have indicated experiencing psychological obstacles that were not described in earlier studies, such as the state of mind they were in as a result of being worried for family members due to war or violence in their home countries, and drop in currency exchange rates and difficulties in acquiring money due to international sanctions imposed against their countries. This study provides important thoughts on the factors that impact the degree progress of international PhD students from Africa, while at the same time revealing a serious gap in the advisers’ role which can contribute to the

  18. Examining students' views about validity of experiments: From introductory to Ph.D. students

    Science.gov (United States)

    Hu, Dehui; Zwickl, Benjamin M.

    2018-06-01

    We investigated physics students' epistemological views on measurements and validity of experimental results. The roles of experiments in physics have been underemphasized in previous research on students' personal epistemology, and there is a need for a broader view of personal epistemology that incorporates experiments. An epistemological framework incorporating the structure, methodology, and validity of scientific knowledge guided the development of an open-ended survey. The survey was administered to students in algebra-based and calculus-based introductory physics courses, upper-division physics labs, and physics Ph.D. students. Within our sample, we identified several differences in students' ideas about validity and uncertainty in measurement. The majority of introductory students justified the validity of results through agreement with theory or with results from others. Alternatively, Ph.D. students frequently justified the validity of results based on the quality of the experimental process and repeatability of results. When asked about the role of uncertainty analysis, introductory students tended to focus on the representational roles (e.g., describing imperfections, data variability, and human mistakes). However, advanced students focused on the inferential roles of uncertainty analysis (e.g., quantifying reliability, making comparisons, and guiding refinements). The findings suggest that lab courses could emphasize a variety of approaches to establish validity, such as by valuing documentation of the experimental process when evaluating the quality of student work. In order to emphasize the role of uncertainty in an authentic way, labs could provide opportunities to iterate, make repeated comparisons, and make decisions based on those comparisons.

  19. The multidisciplinary PhD course: A history and a way forward

    Directory of Open Access Journals (Sweden)

    Ruba Saleh

    2015-12-01

    Full Text Available This paper attempts to trace the last three decades of the PhD in Regional Planning and Public Policies (RPPP at Iuav, Venice.  The programme started in 1985; fifteen years after Giovanni Astengo established an undergraduate course in urban planning at the Iuav  Venice University of Architecture. Astengo was a leading authority on urban planning in the twentieth century, and the founder of the first graduate urban planning program in Italy. On the national level he was a vigorously active urban planner, who contributed both to the drafting of several Italian laws concerning the protection of the territory and landscape,(DOES "protection of the territory and landscape" simply mean 'the environment'? and a number of far-reaching plans. Astengo was the honorary president of the Italian National Institute of Planning (INU from 1986 to 1990.  He also re-founded the magazine Urbanistica, the magazine of the INU in 1949 and directed it for almost three decades.Another significant pioneer, Pierluigi Crosta who coordinated the course for two decades, was, and still is, a leader in the theory and development of the discipline.  Professor Crosta had a clear vision which he communicated to his students. In 2010, Crosta retired and many changes came about. A new coordinator was appointed with a new teaching plan. This paper has two objectives. First of all, it will aim to trace the contributions of Crosta to development of the subject at national level. Secondly, it will try to reflect the viewpoints of some of the PhD candidates who experienced the transition after Crosta, as a way to improve the methodology and organizational structure. Finally, it will speculate on the possibility of establishing a research centre at Iuav for the advancement of studies on contemporary cities.

  20. Delayed Cystectomy for T1G3 Transitional Cell Carcinoma (TCC) of the Urinary Bladder, NCI Retrospective Case Series

    International Nuclear Information System (INIS)

    FAKHR, I.; EL-HOSSIENY, H.; SALAMA, A.

    2008-01-01

    Aim: We aim to evaluate the National Cancer Institute (NCI) treatment protocol and its outcome regarding recurrence, progression and survival in patients with T1G3 urinary bladder transitional cell carcinoma. Patients and Methods: In a retrospective study, between January 2001 and December 2007, all 34 patients with T1G3 bladder transitional cell carcinoma (TCC), after complete transurethral resection (TURBT), received intravesical BCG as adjuvant therapy. A conservative approach was adopted, whereby those with superficial recurrences were eligible to TURBT, with delayed cystectomy for progression to muscle invasion. Overall, recurrence, and progression-free survival were analyzed. Results: Thirty-three patients were included, 29 were males and 4 were females. The mean age was 61 years (range 35-89 years). Final analysis was made at median follow-up of 15 months (Range of 3-68 months, mean 18 months) for survival. Eleven (33.3%) patients had multi- focal tumors. Associated schistosomiasis was present in 12 (36.6%) patients. Twenty-two (66.67%) patients showed recurrence. Eleven out of these 22 (50.0%) patients progressed to muscle invasion and underwent radical cystectomy. Ten out of 34 (30.3%) patients received post- cystectomy radiotherapy. Two (20.0%) of them, were staged as TNM stage II, 6 (60.0%) as TNM stage III and 2 (20.0%) patients were TNM stage IV. Eight (72.7%) of these 11 patients had post-cystectomy radiotherapy alone; while the 2 (6.0%) other patients with stage IV had adjuvant concomitant Cisplatin and Gemcitabine chemotherapy. Five (14%) patients of those cystectomy patients died of TCC. Three (60%) patients died from metastatic disease (to lung, liver and bone), one patient died from advanced locoregional disease and another patient died from post- operative complications. Among those patients who received radiotherapy alone, 62.5% are alive. Although, we report a biologically more aggressive behavior of T1G3 than that reported by some authors

  1. Support for PhD Students: The Impact of Institutional Dynamics on the Pedagogy of Learning Development

    Science.gov (United States)

    Peelo, Moira

    2013-01-01

    This paper explores one practitioner's learning development work with PhD students in a changing university context in which managerialism and financial stringency have combined. It questions how learning development practitioners can maintain their professional goals while negotiating issues arising from managerialism, financial stringency,…

  2. How to measure PhD. students' conceptions of academic writing - and are they related to well-being?

    Directory of Open Access Journals (Sweden)

    Kirsti Lonka

    2014-02-01

    Full Text Available This study investigated PhD students’ conceptions of writing and how they saw themselves as writers. The Writing Process Questionnaire was created to analyse PhD students’ ideas of academic writing. In addition, it was of interest, what the relation between conceptions of writing and the PhD students’ well-being was. The participants were 669 PhD students from a major Finnish university who volunteered to fill in a questionnaire. The present study covered scales for measuring six distinct theoretical constructs that were created by forming sum variables of 26 questions: Blocks, Procrastination, Perfectionism, Innate ability, Knowledge transforming, and Productivity. Confirmatory factor analysis (CFA was used to verify the six-dimension construct. Exhaustion, stress, anxiety and lack of interest all correlated positively with Blocks, Procrastination, and Perfectionism, and negatively with Productivity. Confirmatory factor analysis conducted by LISREL confirmed the six-factor structure of the writing scale. In conclusion, there is good evidence that the questionnaire is a reliable and valid tool, and it captures some essential aspectsof academic writing process and its emotional dimensions.

  3. Human radiation studies: Remembering the early years. Oral history of Biochemist Waldo E. Cohn, Ph.D

    International Nuclear Information System (INIS)

    1995-01-01

    In September 1994, the Department of Energy began an oral history project as part of the Openess initiative on the documentation of the human radiation experiments. This paper presents the oral history of Waldo E Cohn, Ph.D., a Biochemist who worked for the Oak Ridge National Laboratory and the Manhattan Project

  4. Trends in Ph.D. Productivity and Diversity in Top-50 U.S. Chemistry Departments: An Institutional Analysis

    Science.gov (United States)

    Laursen, Sandra L.; Weston, Timothy J.

    2014-01-01

    The education of doctoral chemists contributes to the chemical research enterprise and thus to innovation as an engine of the economy. This quantitative analysis describes trends in the production and diversity of chemistry Ph.D. degrees in the top-50 U.S. Ph.D.-granting departments in the past two decades. Time series data for individual…

  5. An Impact Analysis of Regional Industry--University Interactions: The Case of Industrial PhD Schools

    Science.gov (United States)

    Gustavsson, Linda; Nuur, Cali; Söderlind, Johan

    2016-01-01

    The authors discuss Triple Helix collaborations in the context of regional competitiveness. Through an exploratory case study, they identify and analyse the impact of the establishment of industrial PhD schools for participating industry and universities. The study was conducted in Sweden in 2014 and focuses on three industry--university…

  6. An Impact Analysis of Regional Industry-University Interactions: The Case of Industrial PhD Schools

    Science.gov (United States)

    Gustavsson, Linda; Nuur, Cali; Söderlind, Johan

    2016-01-01

    The authors discuss Triple Helix collaborations in the context of regional competitiveness. Through an exploratory case study, they identify and analyse the impact of the establishment of industrial PhD schools for participating industry and universities. The study was conducted in Sweden in 2014 and focuses on three industry-university…

  7. Research Productivity of LIS Schools in Pakistan: A Study of MPhil and PhD Theses to 2015

    Science.gov (United States)

    Sheikh, Arslan; Jan, Saeed Ullah

    2017-01-01

    This article aims to present a comprehensive review of MPhil and PhD research theses produced by library and information science (LIS) schools in Pakistan from their beginning to 2015. It also explores the research trends in LIS, identifies gaps, and presents an agenda for future research by LIS scholars. The origin, development, and current…

  8. PhD Students' Experiences of Thesis Supervision in Malaysia: Managing Relationships in the Midst of Institutional Change

    Science.gov (United States)

    Krauss, Steven Eric; Ismail, Ismi Arif

    2010-01-01

    Despite the plethora of studies that have been conducted on PhD supervision, little qualitative investigation has been conducted with a diverse, non-Western sample of doctoral students in an attempt to understand how the supervisory relationship is experienced. In response, eighteen students from diverse, non-Western backgrounds studying at one…

  9. Move-step structures of literature Ph.D. theses in the Japanese and UK higher education

    Directory of Open Access Journals (Sweden)

    Masumi Ono

    2017-02-01

    Full Text Available This study investigates the move-step structures of Japanese and English introductory chapters of literature Ph.D. theses and perceptions of Ph.D. supervisors in the Japanese and UK higher education contexts. In this study, 51 Japanese and 48 English introductory chapters of literature Ph.D. theses written by first language writers of Japanese or English were collected from three Japanese and three British universities. Genre analysis of 99 introductory chapters was conducted using a revised “Create a Research Space” (CARS model (Swales, 1990, 2004. Semi-structured interviews were also carried out with seven Japanese supervisors and ten British supervisors. The findings showed that the introductory chapters of literature Ph.D. theses had 13 move-specific steps and five move-independent steps, each of which presented different cyclical patterns, indicating cross-cultural similarities and differences between the two language groups. The perceptions of supervisors varied in terms of the importance and the sequence of individual steps in the introductory chapters. Based on the textual and interview analyses, a discipline-oriented Open-CARS model is proposed for pedagogical purposes of teaching and writing about this genre in Japanese or English in the field of literature and related fields.

  10. Assessment Procedures of Norwegian PhD Theses as Viewed by Examiners from the USA, the UK and Sweden

    Science.gov (United States)

    Kyvik, Svein

    2014-01-01

    This article focuses on the assessment procedures of Norwegian PhD theses as viewed by external members of evaluation committees from three countries with different examination systems; the USA, the UK and Sweden. Their viewpoints give useful information not only on the pros and cons with the Norwegian system, but also on the strengths and…

  11. Multimodal Identity Texts as Mediational Spaces in Researching Ph.D. Students' Critical Teacher-Researcher Selves

    Science.gov (United States)

    Valencia, Marlon; Herath, Sreemali

    2015-01-01

    This paper analyses how two Ph.D. students used multimodal identity texts (MMITs) to document their research journeys as they engaged in their doctoral studies. Drawing on qualitative data collected from multiple pre-service teacher preparation programmes in Chile and Sri Lanka, two bi-national researchers (a Colombian-Canadian and a Sri…

  12. Device interoperability and authentication for telemedical appliance based on the ISO/IEEE 11073 Personal Health Device (PHD) Standards.

    Science.gov (United States)

    Caranguian, Luther Paul R; Pancho-Festin, Susan; Sison, Luis G

    2012-01-01

    In this study, we focused on the interoperability and authentication of medical devices in the context of telemedical systems. A recent standard called the ISO/IEEE 11073 Personal Health Device (X73-PHD) Standards addresses the device interoperability problem by defining common protocols for agent (medical device) and manager (appliance) interface. The X73-PHD standard however has not addressed security and authentication of medical devices which is important in establishing integrity of a telemedical system. We have designed and implemented a security policy within the X73-PHD standards. The policy will enable device authentication using Asymmetric-Key Cryptography and the RSA algorithm as the digital signature scheme. We used two approaches for performing the digital signatures: direct software implementation and use of embedded security modules (ESM). The two approaches were evaluated and compared in terms of execution time and memory requirement. For the standard 2048-bit RSA, ESM calculates digital signatures only 12% of the total time for the direct implementation. Moreover, analysis shows that ESM offers more security advantage such as secure storage of keys compared to using direct implementation. Interoperability with other systems was verified by testing the system with LNI Healthlink, a manager software that implements the X73-PHD standard. Lastly, security analysis was done and the system's response to common attacks on authentication systems was analyzed and several measures were implemented to protect the system against them.

  13. Methods of Academic Course Planning for Cancer Biology PhD Students to Enhance Knowledge of Clinical Oncology.

    Science.gov (United States)

    Mattes, Malcolm D; Swart, Elizabeth; Markwell, Steven M; Wen, Sijin; Vona-Davis, Linda C

    2017-09-15

    Little is known about how clinical oncology concepts are taught to PhD students or the most effective methods of doing so. In this study, electronic surveys were sent to faculty and students at PhD training programs, assessing their institution's methods of clinical oncology education and their perspective on optimal approaches to clinical oncology education. Only 40.0% of students reported any clinical oncology component to their institution's training, and only 26.5% had a clinician on their graduate advisory committee. Forty-three percent of students believed that they had a good understanding for translating basic science research into clinical practice, and 77.2% of all participants believed dual degree MD/PhD students were superior to PhD students in this regard. Lectures on clinical oncology research topics were the most valuable type of experience for all participants and were also the most common type of experience utilized. Working with a clinician to develop a clinical trial with correlative endpoints was also highly valued, but was only utilized by approximately 10% of programs. Faculty rated the value of nearly all types of clinical oncology exposure significantly lower than did students. Inclusion of the approaches identified in this study is likely to enhance PhD training in oncology-related disciplines. Cancer Res; 77(18); 4741-4. ©2017 AACR . ©2017 American Association for Cancer Research.

  14. Thai PhD Students and Their Supervisors at an Australian University: Working Relationship, Communication, and Agency

    Science.gov (United States)

    Nomnian, Singhanat

    2017-01-01

    PhD supervision is crucial for higher degree research students in western academic contexts. Despite an increasing body of literature regarding the international student-supervisor relationship, Thai students in Australian higher education are under-represented. This qualitative study aims to explore discursive practices that impact on Thai…

  15. A Study on Changes of Supervision Model in Universities and Fostering Creative PhD Students in China

    DEFF Research Database (Denmark)

    Luo, Lingling; Zhou, Chunfang; Zhang, Song

    2015-01-01

    This paper aims to explore the changes of supervision model in higher education in relation to fostering creative Ph.D. students in China. The changes are being made from the traditional Apprentice Master Model (AMM) to the modern Collaborative Cohort Model (CCM). According to the results...

  16. MS PHD'S: Bridging the Gap of Academic and Career Success Through Educational and Professional Development for Minorities

    Science.gov (United States)

    Brown, D.; Vargas, W.; Padilla, E.; Strickland, J.; Echols, E.; Johnson, A.; Williamson Whitney, V.; Ithier-Guzman, W.; Ricciardi, L.; Johnson, A.; Braxton, L.

    2011-12-01

    Historically, there has been a lack of ethnic and gender diversity in the geo-sciences. The Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S) Professional Development Program provides a bridge to young scientists of diverse backgrounds who in turn will impact many. In a process of 3 phases, the program introduces the students to the scientific community through participation in professional and society meetings and networking with scientists and personnel within federal agencies, academic institutions and STEM-based industries. The program builds confidence, offers role models for professional development and provides students support during their education. Upon completion, students achieve a high level of self-actualization and self-esteem combined with individual growth. They become part of a community that continuously provides support and security to each other. This support is tangible through the mentor/mentee relationships which will help with individual growth throughout the mentoring cycle. Having role models and familiar faces to whom mentees can relate to will encourage our students to succeed in the STEM's field. To date, 159 students have participated in the program: 26 have successfully completed their PhD and 56 are currently enrolled in the PhD programs nationwide. The MS PHD'S Program creates a forum of diverse peoples by diverse peoples with diverse interest and strength, where the ongoing goal is to continually raise the bar for each individual. MS PHD'S establishes a nurturing goal-oriented environment for the geo scientist of the future who in turn will make profound contributions on a local, national and global scale. To conclude, MSPHD'S not only bridges the gap of unrepresented minorities in STEM careers, but also generates educational approaches to make the earth system sciences available to more, impacting all.

  17. Protocol per a la implantació d’eines didàctiques virtuals: competències i habilitats adquirides pels estudiants

    Directory of Open Access Journals (Sweden)

    Laura Guitart Tarrés

    2011-06-01

    Full Text Available L’adaptació al nou espai europeu d’educació superior (EEES ha plantejat alguns canvis en l’enfocament de la formació universitària al nostre país. On abans era el docent el protagonista, ara és l’estudiant el que pren el rol d’actor principal de la seva formació, i l’aprenentatge s’orienta cap a una autonomia i reflexió més grans. En aquest escenari, les noves tecnologies ofereixen un ampli ventall d’opcions per millorar els processos formatius. En aquests sentit, el Grup d’Innovació Docent G•IDEA ha participat activament en aquest procés d’adaptació des de ja fa uns quants anys, i ha creat una sèrie de recursos docents digitals que han estat àmpliament provats en diversos ensenyaments de la Facultat d’Economia i Empresa de la Universitat de Barcelona. L’objectiu d’aquest article és presentar el protocol dissenyat per l’equip d’investigadors del G•IDEA per implantar aquestes eines didàctiques (webquestes i exercicis tutoritzats, i també els resultats d’una enquesta de satisfacció sobre les competències i habilitats adquirides pels nostres estudiants en la utilització dels recursos. Els resultats mostren, d’una banda, que no ha estat possible crear un mateix protocol aplicable a tots els recursos, a causa de les diferències en els objectius didàctics de les distintes eines docents implantades. D’altra banda, la valoració que els estudiants fan de la utilització de les eines és molt positiva, tot i que hi ha algunes diferències entre els recursos analitzats. Conèixer la valoració que l’alumnat fa d’aquests recursos permet al grup d’investigadors poder-los millorar i adequar al perfil dels estudiants perquè aquests en puguin treure el màxim profit possible.

  18. La història de les ciències en l'ensenyament de la física i la química

    OpenAIRE

    Traver i Ribes, Manel Josep

    1996-01-01

    TESI DOCTORAL : “LA HISTÒRIA DE LES CIÈNCIES EN L’ENSENYAMENT DE LA FÍSICA I LA QUÍMICA” RESUM El problema que s’ha investigat en aquest treball consisteix en l’anàlisi del paper que juga actualment la Història de la Ciència en l’ensenyament de la Física i la Química i de la seua influència en la imatge de la ciència i en les actituds dels alumnes. S’hi han investigat dues hipòtesis principals. La primera consisteix en la constatació de l’escàs paper atribuït habitualment a la His...

  19. Screening mammography. A missed clinical opportunity? Results of the NCI [National Cancer Institute] Breast Cancer Screening Consortium and national health interview survey studies

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    Data from seven studies sponsored by the National Cancer Institute (NCI) were used to determine current rates of breast cancer screening and to identify the characteristics of and reasons for women not being screened. All seven studies were population-based surveys of women aged 50 to 74 years without breast cancer. While over 90% of non-Hispanic white respondents had regular sources of medical care, 46% to 76% had a clinical breast examination within the previous year, and only 25% to 41% had a mammogram. Less educated and poorer women had fewer mammograms. The two most common reasons women gave for never having had a mammogram were that they did not known they needed it and that their physician had not recommended it. Many physicians may have overlooked the opportunity to recommend mammography for older women when performing a clinical breast examination and to educate their patients about the benefit of screening mammography

  20. The Ph-D project: Manned expedition to the Moons of Mars

    Science.gov (United States)

    Singer, S. Fred

    2000-01-01

    The Ph-D (Phobos-Deimos) mission involves the transfer of six to eight men (and women), including two medical scientists, from Earth orbit to Deimos, the outer satellite of Mars. There follows a sequential program of unmanned exploration of the surface of Mars by means of some ten to twenty unmanned rover vehicles, each of which returns Mars samples to the Deimos laboratory. A two-man sortie descends to the surface of Mars to gain a direct geological perspective and develop priorities in selecting samples. At the same time, other astronauts conduct a coordinated program of exploration (including sample studies) of Phobos and Deimos. Bringing men close to Mars to control exploration is shown to have scientific and other advantages over either (i) (manned) control from the Earth, or (ii) manned operations from Mars surface. The mission is envisaged to take place after 2010, and to last about two years (including a three-to six-month stay at Deimos). Depending on then-available technology, take-off weight from Earth orbit is of the order of 300 tons. A preferred mission scheme may preposition propellants and equipment at Deimos by means of ``slow freight,'' possibly using a ``gravity boost'' from Venus. It is then followed by a ``manned express'' that conveys the astronauts more rapidly to Deimos. Both chemical and electric propulsion are used in this mission, as appropriate. Electric power is derived from solar and nuclear sources. Assuming that certain development costs can be shared with space-station programs, the incremental cost of the project is estimated as less than $40 billion (in 1998 dollars), expended over a 15-year period. The potential scientific returns are both unique and important: (i) Establishing current or ancient existence of life-forms on Mars; (ii) Understanding the causes of climate change by comparing Earth and Mars; (iii) Martian planetary history; (iv) Nature and origin of the Martian moons. Beyond the Ph-D Project, many advanced programs

  1. A Micro-Grid Simulator Tool (SGridSim) using Effective Node-to-Node Complex Impedance (EN2NCI) Models

    Energy Technology Data Exchange (ETDEWEB)

    Udhay Ravishankar; Milos manic

    2013-08-01

    This paper presents a micro-grid simulator tool useful for implementing and testing multi-agent controllers (SGridSim). As a common engineering practice it is important to have a tool that simplifies the modeling of the salient features of a desired system. In electric micro-grids, these salient features are the voltage and power distributions within the micro-grid. Current simplified electric power grid simulator tools such as PowerWorld, PowerSim, Gridlab, etc, model only the power distribution features of a desired micro-grid. Other power grid simulators such as Simulink, Modelica, etc, use detailed modeling to accommodate the voltage distribution features. This paper presents a SGridSim micro-grid simulator tool that simplifies the modeling of both the voltage and power distribution features in a desired micro-grid. The SGridSim tool accomplishes this simplified modeling by using Effective Node-to-Node Complex Impedance (EN2NCI) models of components that typically make-up a micro-grid. The term EN2NCI models means that the impedance based components of a micro-grid are modeled as single impedances tied between their respective voltage nodes on the micro-grid. Hence the benefit of the presented SGridSim tool are 1) simulation of a micro-grid is performed strictly in the complex-domain; 2) faster simulation of a micro-grid by avoiding the simulation of detailed transients. An example micro-grid model was built using the SGridSim tool and tested to simulate both the voltage and power distribution features with a total absolute relative error of less than 6%.

  2. Usual Intake Distribution of Vitamins and Prevalence of Inadequacy in a Large Sample of Iranian At-Risk Population: Application of NCI Method.

    Science.gov (United States)

    Heidari, Zahra; Feizi, Awat; Azadbakht, Leila; Sarrafzadegan, Nizal

    2016-01-01

    This study provides an assessment of usual intake distribution of vitamins and estimating prevalence of inadequacy and excess among a large representative sample of middle-aged and elderly people in central regions of Iran. A cross-sectional study that is a second follow-up to the Isfahan Cohort Study (ICS). The study setting included urban and rural areas from 3 cities (Isfahan, Najafabad, and Arak) in central regions of Iran. Subjects included 1922 people aged 40 years and older, with a mean age of 55.9 ± 10.6; 50.4% were male and the majority (79.3%) were urban. Dietary intakes were collected using a 24-hour recall and 2 food records. Distribution of vitamins intake was estimated using traditional and national cancer institute (NCI) methods. The proportion of subjects at risk of vitamin intake inadequacy or excess was estimated using the estimated average requirement (EAR) cut-point method and the tolerable upper intake levels (UL) index. There were differences between values obtained from traditional and NCI methods, particularly in the lower and upper percentiles of the intake distribution. High prevalence of inadequacies for vitamins A, D, E, B2, B3 (especially among females), and B9 was observed. Significant gender differences were found in terms of inadequate intakes for vitamins A, B1, B2, B3, B6, B9, B12, and C (p vitamin intake was observed in the middle-aged and elderly Iranian population. Nutritional interventions particularly through population-based educational programs in order to improve diet variety and consume nutrient supplements may be necessary.

  3. Theoretical analysis of the binding of iron(III) protoporphyrin IX to 4-methoxyacetophenone thiosemicarbazone via DFT-D3, MEP, QTAIM, NCI, ELF, and LOL studies.

    Science.gov (United States)

    Nkungli, Nyiang Kennet; Ghogomu, Julius Numbonui

    2017-07-01

    Thiosemicarbazones display diverse pharmacological properties, including antimalarial activities. Their pharmacological activities have been studied in depth, but little of this research has focused on their antimalarial mode of action. To elucidate this antimalarial mechanism, we investigated the nature of the interactions between iron(III) protoporphyrin IX (Fe(III)PPIX) and the thione-thiol tautomers of 4-methoxyacetophenone thiosemicarbazone (MAPTSC). Dispersion-corrected density functional theory (DFT-D3), the quantum theory of atoms in molecules (QTAIM), the noncovalent interaction (NCI) index, the electron localization function (ELF), the localized orbital locator (LOL), and thermodynamic calculations were employed in this work. Fe(III)PPIX-MAPTSC binding is expected to inhibit hemozoin formation, thereby preventing Fe(III)PPIX detoxification in plasmodia. Preliminary studies geared toward the identification of atomic binding sites in the thione-thiol tautomers of MAPTSC were carried out using molecular electrostatic potential (MEP) maps and conceptual DFT-based local reactivity indices. The thionic sulfur and the 2 N-azomethine nitrogen/thiol sulfur of, respectively, the thione and thiol tautomers of MAPTSC were identified as the most favorable nucleophilic sites for electrophilic attack. The negative values of the computed Fe(III)PPIX-MAPTSC binding energies, enthalpies, and Gibbs free energies are indicative of the existence and stability of Fe(III)PPIX-MAPTSC complexes. MAPTSC-Fe(III) coordinate bonds and strong hydrogen bonds (N-H···O) between the NH 2 group in MAPTSC and the C=O group in one propionate side chain of Fe(III)PPIX are crucial to Fe(III)PPIX-MAPTSC binding. QTAIM, NCI, ELF, and LOL analyses revealed a subtle interplay of weak noncovalent interactions dominated by dispersive-like van der Waals interactions between Fe(III)PPIX and MAPTSC that stabilize the Fe(III)PPIX-MAPTSC complexes.

  4. Improving Doctoral Success by Matching PhD Students with Supervisors

    Directory of Open Access Journals (Sweden)

    Antònia Darder

    2016-02-01

    Full Text Available A key aspect of the effective supervision of PhD research is the supervisor-student relationship. This interaction is affected by the characteristics and needs of students and institutional conditions, as well as the skills, attitudes, and roles of supervisors and their supervisory styles. When supervision is carried out at a distance, it entails an additional challenge, mainly concerning interaction. The purpose of this study is to improve the research process, supervision, and design of virtual environments in order to support this supervision. The study identifies the supervisory relationships that affect doctoral research conducted at a distance from the student’s academic institution. It also describes how students and their supervisors perceived the characteristics of supervision and the skills and attitudes students perceived in and expected from their supervisors. For data collection, semistructured interviews were used. The results indicate important differences between supervisors’ perceptions concerning their own role and students’ needs regarding supervision, and they demonstrate the importance of attending to student needs and, on the part of supervisors, exercising responsibility in the development of research competencies in students, as is the case of independence of criteria and autonomy.

  5. The postgraduate students’ (masters, PhD metaphors about education of statistic

    Directory of Open Access Journals (Sweden)

    Colak Serap

    2016-01-01

    Full Text Available Statistics is an important part of our life when it comes to economy, education, sport, politics and research. Research is a primary job for the ones pursuing academic career and statistics is one of the basic components of a research. Metaphor is used as an equivalent to figurative expression (‘mecaz’ in Turkish language. Study group is composed of 19 females (age 27.7 and 40 males (age 30.85 - 59 students in total. Demographic information of participants was collected. Participants were provided with questionnaire in order to assess their metaphorical creation whereby they were asked to fill in the sentence - “statistics is like/ similar to …, because…” - with metaphor. The study has collected total of 59 metaphors in 6 categories. The most created metaphor is in ‘discovering/ revealing’ category. 42.5% of Master’s students and 25% of PhD students are in this category. Metaphors created by graduate students are representing their views about statistics course and hence their view about importance of research. The category ‘discovering/ revealing’, the one with the most created metaphor of this study, is the main concept of science. Consequently, good knowledge of statistics is needed for graduate students to conduct research.

  6. Healing in forgiveness: A discussion with Amanda Lindhout and Katherine Porterfield, PhD

    Directory of Open Access Journals (Sweden)

    Katherine A. Porterfield

    2014-09-01

    Full Text Available In 2008, Amanda Lindhout was kidnapped by a group of extremists while traveling as a freelance journalist in Somalia. She and a colleague were held captive for more than 15 months, released only after their families paid a ransom. In this interview, Amanda discusses her experiences in captivity and her ongoing recovery from this experience with Katherine Porterfield, Ph.D. a clinical psychologist at the Bellevue/NYU Program for Survivors of Torture. Specifically, Amanda describes the childhood experiences that shaped her thirst for travel and knowledge, the conditions of her kidnapping, and her experiences after she was released from captivity. Amanda outlines the techniques that she employed to survive in the early aftermath of her capture, and how these coping strategies changed as her captivity lengthened. She reflects on her transition home, her recovery process, and her experiences with mental health professionals. Amanda's insights provide an example of resilience in the face of severe, extended trauma to researchers, clinicians, and survivors alike. The article ends with an discussion of the ways that Amanda's coping strategies and recovery process are consistent with existing resilience literature. Amanda's experiences as a hostage, her astonishing struggle for physical and mental survival, and her life after being freed are documented in her book, co-authored with Sara Corbett, A House in the Sky.

  7. The accuracy of references in PhD theses: a case study.

    Science.gov (United States)

    Azadeh, Fereydoon; Vaez, Reyhaneh

    2013-09-01

    Inaccurate references and citations cause confusion, distrust in the accuracy of a report, waste of time and unnecessary financial charges for libraries, information centres and researchers. The aim of the study was to establish the accuracy of article references in PhD theses from the Tehran and Tabriz Universities of Medical Sciences and their compliance with the Vancouver style. We analysed 357 article references in the Tehran and 347 in the Tabriz. Six bibliographic elements were assessed: authors' names, article title, journal title, publication year, volume and page range. Referencing errors were divided into major and minor. Sixty two percent of references in the Tehran and 53% of those in the Tabriz were erroneous. In total, 164 references in the Tehran and 136 in the Tabriz were complete without error. Of 357 reference articles in the Tehran, 34 (9.8%) were in complete accordance with the Vancouver style, compared with none in the Tabriz. Accuracy of referencing did not differ significantly between the two groups, but compliance with the Vancouver style was significantly better in the Tehran. The accuracy of referencing was not satisfactory in both groups, and students need to gain adequate instruction in appropriate referencing methods. © 2013 The authors. Health Information and Libraries Journal © 2013 Health Libraries Group.

  8. ANALYSIS OF METHODICAL DEFECTS IN PHD AND DOCTORAL THESIS ON ECONOMICS

    Directory of Open Access Journals (Sweden)

    R. D. Gutgarts

    2016-01-01

    Full Text Available The aim of the article is to consider the most typical defectswhich can be found in PhD and doctoral dissertations on economic sciences. The research is based on a work experience of the author as the member of dissertation council, the reviewer and the opponent of dissertation works.Methods. The methods of the analysis, comparison, and generalization are used while researching the problem.Results and scientific novelty. The miscalculations and errors in master’s and doctoral dissertations on economics which have methodical nature and not depend on a specific subject of work are disclosed and systematized. In particular, the following questions concerning the process of work are studied out on specific examples: work with information sources, Internet resources; options of correct and incorrect use o tools of information technologies; applied problems of results of scientific research, etc.Practical significance of the publication consists, firstly, in recommendations of the author concerning leveling and elimination of common defects of dissertation works and scientific articles; secondly, in the proposal of the general and methodical plan for introduction of training standards in a postgraduate study.

  9. Ballistic Target PHD Filter Based on Infrared Focal Plane Ambiguous Observation

    Directory of Open Access Journals (Sweden)

    Wei Zhao

    2017-01-01

    Full Text Available Space-based early warning system, the main detection means of which is passive detection based on focal plane, is an important part of ballistic missile defense system. The focal plane is mainly composed of CCD, and its size can reach the micron level, so the pixel is often regarded as point of no area in image postprocessing. The design of traditional tracking methods is based on this, and the observation based on the focal plane is modeled as the azimuth with random noise. However, this modeling is inaccurate. In the context of space-based detection, CCD cannot be simplified as a point, and its size should be considered. And the corresponding observation cannot be treated as azimuth with random noise. In this paper, the observation based on focal plane is modeled as Unambiguously Generated Ambiguous (UGA measurement. The PHD filter algorithm is redesigned and simplified. The simulation results show that the algorithm based on UGA measurement observation model has better tracking effect compared with that based on traditional observation model. This method provides technical support for more accurate target tracking for space-based early warning system.

  10. A conserved PHD finger protein and endogenous RNAi modulate insulin signaling in Caenorhabditis elegans.

    Science.gov (United States)

    Mansisidor, Andres R; Cecere, Germano; Hoersch, Sebastian; Jensen, Morten B; Kawli, Trupti; Kennedy, Lisa M; Chavez, Violeta; Tan, Man-Wah; Lieb, Jason D; Grishok, Alla

    2011-09-01

    Insulin signaling has a profound effect on longevity and the oxidative stress resistance of animals. Inhibition of insulin signaling results in the activation of DAF-16/FOXO and SKN-1/Nrf transcription factors and increased animal fitness. By studying the biological functions of the endogenous RNA interference factor RDE-4 and conserved PHD zinc finger protein ZFP-1 (AF10), which regulate overlapping sets of genes in Caenorhabditis elegans, we identified an important role for these factors in the negative modulation of transcription of the insulin/PI3 signaling-dependent kinase PDK-1. Consistently, increased expression of pdk-1 in zfp-1 and rde-4 mutants contributed to their reduced lifespan and sensitivity to oxidative stress and pathogens due to the reduction in the expression of DAF-16 and SKN-1 targets. We found that the function of ZFP-1 in modulating pdk-1 transcription was important for the extended lifespan of the age-1(hx546) reduction-of-function PI3 kinase mutant, since the lifespan of the age-1; zfp-1 double mutant strain was significantly shorter compared to age-1(hx546). We further demonstrate that overexpression of ZFP-1 caused an increased resistance to oxidative stress in a DAF-16-dependent manner. Our findings suggest that epigenetic regulation of key upstream signaling components in signal transduction pathways through chromatin and RNAi may have a large impact on the outcome of signaling and expression of numerous downstream genes.

  11. Frizzled to finance: one PhD's path from a Drosophila lab to Wall Street.

    Science.gov (United States)

    Taylor, Job

    2016-06-01

    An equity research analyst's job is to determine whether the price of a stock is likely to go up or down. For science-based businesses, particularly biotechnology companies, a PhD in the life sciences can be very helpful in making this determination. I transitioned from a postdoc position to working in equity research. Here I present information on how I made the transition, an overview of the day-to-day activities of an analyst, and thoughts on how to prepare to look for a job in finance. There are significant positives to working on Wall Street, including exposure to cutting-edge clinical/translational research, access to some of the best scientists in the world, a dynamic work environment, and compensation that generally exceeds academic salaries. This comes at the cost of some independence and the satisfaction of being able to call oneself a scientist. © 2016 Taylor. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  12. What Does It Take? Auto/biography as Performative PhD Thesis

    Directory of Open Access Journals (Sweden)

    Sally Berridge

    2008-05-01

    Full Text Available Recently I completed a performative (creative PhD in the School of Creative Communication (now the Faculty of Design and Creative Practice at the University of Canberra, Australia, where such doctorates were established only in 2002. Since I completed in 2006, I have been contemplating some process issues that emerged during my three and a half year's studies. While conferring with fellow students and colleagues at three universities in England, I found that the many of the problems they encountered were similar and so were not due uniquely to the innovative phase that I encountered, but were part of a wider scenario. At my university, the requirements for a creative doctorate are a creative component (equivalent to about 60,000 words and a theoretical component (exegesis of about 30,000 words. The physical outcome of my thesis is two artist's books: one, Tissue, is autobiographical, while questioning the nature of autobiography, memory and identity. The other, Re-Picturing My Life, is the theoretical component, examining several paradigms including issues of methodology; the value of art as research; theories of memory, identity, autobiography, and human interactions with objects. I have placed some of my text/images in this paper to provide a taste of the work in my thesis. My paper reflects on performative work in the context of academic research, and the resilience, determination and sense of humour needed to complete a doctorate successfully in this valuable area of endeavour. URN: urn:nbn:de:0114-fqs0802451

  13. Stepping Stones to Research: Providing Pipelines from Middle School through PhD

    Science.gov (United States)

    Noel-Storr, Jacob; Baum, S. A.; RIT Insight Lab SSR Team; Carlson CenterImaging Science Faculty, Chester F.

    2014-01-01

    We present a decade's worth of strategies designed to promote and provide "Stepping Stones to Research" to provide a realistic pipeline of educational opportunities, with multiple gateways and exit points, for students moving towards STEM careers along the "STEM pipeline". We also illustrate how the Stepping Stones are designed to incidentally co-inside with related external opportunities through which we can also guide and support our mentees on their paths. We present programs such as middle school family science programs, high school research opportunities, high school internships, undergraduate research pathways, research experiences for undergraduates, and other opportunities. We will highlight the presentations being made at this very meeting -- from the first presentation of a high school student, to a dissertation presentation of a PhD graduate -- that have benefited from this stepping stone principle. We also reflect on the essential nature of building a "researcher-trust", even as a young student, of advocates and mentors who can support the continuation of a scientific career.

  14. Shaping the esp curriculum of an english for PhD students program: a colombian case study of questionnaire research

    Directory of Open Access Journals (Sweden)

    Gerriet Janssen

    2012-12-01

    Full Text Available This report presents the findings from an EAP curriculum development project directed towards PhD students at Colombian university.An analysis of this stakeholder group’s learning needs was conducted through questionnaire research, focusing on (a describing students’situated contexts and interests and (b obtaining data contributing towards future program development. Measures of central tendency,dispersion, and internal consistency for each section of the questionnaire are reported. Key results include these students’ strong interest inEAP programming, their language needs and experience regarding their intellectual production, and their perceived importance of differentlanguage sub-skills in both the local and international contexts. The results highlight the importance of continued evaluation cycles and theimportant role EAP coursework has for PhD students today.

  15. Eberhard Widmann (Stefan Meyer Institute, Vienna) and Silke Federmann (Ph.D. Student from Vienna in the CERN-Austrian Ph.D. program) together with a microwave cavity developed by Silke at CERN. The cavity will be used for the first time to look for spin-flip transitions of antihydrogen atoms later this year.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    Eberhard Widmann (Stefan Meyer Institute, Vienna) and Silke Federmann (Ph.D. Student from Vienna in the CERN-Austrian Ph.D. program) together with a microwave cavity developed by Silke at CERN. The cavity will be used for the first time to look for spin-flip transitions of antihydrogen atoms later this year.

  16. ChemSession'07 - 4{sup th} Seminary of Warsaw PhD Students in Chemistry. Abstracts

    Energy Technology Data Exchange (ETDEWEB)

    Dobrowolski, J C [Industrial Chemistry Research Institute, Warsaw (Poland); National Institute of Drugs, Warsaw (Poland); Ostrowski, S [Industrial Chemistry Research Institute, Warsaw (Poland); Madura, I; Sporzynski, A; Szatylowicz, H; Zubrowska, A [Warsaw University of Technology, Warsaw (Poland)

    2007-07-01

    4{sup th} Annual Seminary of Warsaw PhD Students in Chemistry presented the latest achievements in chemistry, obtained in all Warsaw universities and scientific institutes. In 2007 participants presented 4 plenary lectures, and 101 posters. Among others, posters covered four disciplines related to the nuclear sciences: (a) radiobiology and radiotherapy, (b) radiation chemistry and photochemistry, (c) isotopic effects in chemistry, and (d) chemical technology.

  17. ChemSession'06 - 3{sup rd} Seminary of Warsaw PhD Students in Chemistry. Abstracts

    Energy Technology Data Exchange (ETDEWEB)

    Zachara, J; Lulinski, S [Warsaw University of Technology, Warsaw (Poland); Dobrowolski, J C [Industrial Chemistry Research Institute, Warsaw (Poland); National Institute of Drugs, Warsaw (Poland); Raczynska, E D [Warsaw University of Life Sciences (SGGW), Warsaw (Poland); Fuks, L [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Cyranski, M K; Stepien, B T [University of Warsaw, Warsaw (Poland); Sawicki, M G [Cecylia Plater-Zylberkowna High School, Warsaw (Poland)

    2006-07-01

    3{sup rd} Annual Seminary of Warsaw PhD Students in Chemistry presented the latest achievements in chemistry, obtained in all Warsaw universities and scientific institutes. In 2006 participants presented 4 plenary lectures, and 109 posters. Among others, posters covered four disciplines related to the nuclear sciences: (a) radiobiology and radiotherapy, (b) radiation chemistry and photochemistry, (c) isotopic effects in chemistry, and (d) chemical technology.

  18. Simulation Programs for Ph.D. Study of Analysis, Modeling and Optimum Design of Solar Domestic Hot Water Systems

    DEFF Research Database (Denmark)

    Qin, Lin

    1999-01-01

    The design of solar domestic hot water system is a complex process, due to characteristics inherent in solar heating technology. Recently, computer simulation has become a widely used technique to improve the understanding of the thermal processes in such systems. This report presents the detaile...... programs or units that were developed in the Ph.D study of " Analysis, Modeling and Optimum Design of Solar Domestic Hot Water Systems"....

  19. A biographical note on Max Friedrich (1856-1887), Wundt's first PhD student in experimental psychology.

    Science.gov (United States)

    Domanski, Cezary W

    2004-01-01

    This article unveils some previously unknown facts about the short life of Max Friedrich (1856-1887), the author in 1881 of the first PhD dissertation on experimental psychology, written under the supervision of Wilhelm Wundt: "On the Duration of Apperception for Simple and Complex Visual Stimuli." The article describes Friedrich's family background and life, professional career as a teacher, and works in psychology and mathematics. Copyright 2004 Wiley Periodicals, Inc.

  20. A National Survey Examining Manuscript Dissertation Formats Among Nursing PhD Programs in the United States.

    Science.gov (United States)

    Graves, Janessa M; Postma, Julie; Katz, Janet R; Kehoe, Leanne; Swalling, Eileen; Barbosa-Leiker, Celestina

    2018-03-08

    Among research-focused nursing doctoral (PhD) programs in the United States, the traditional dissertation format has recently given way to a series of publication-ready manuscripts, often bookended by introduction and conclusion chapters. To help programs make decisions about the use of these formats, this study undertook a national survey of programs offering PhDs in nursing. The purpose of this study was to explore the advantages and disadvantages of the traditional format versus manuscript option for dissertations among nursing PhD programs in the United States. Cross-sectional census survey of U.S. nursing PhD programs. A web-based survey was administered to all U.S. nursing PhD programs. Respondents indicated formats offered, factors contributing to decisions of which formats to offer, and lessons learned. Descriptive statistics and inductive content analyses were used for analysis. Of 121 eligible institutions, 79 provided eligible responses (66.7%). The majority (59%) offered both formats; 11% offered the manuscript option only, and 24% offered the traditional format only. Faculty support (or lack thereof) contributed to adoption (or not) of the manuscript option. Respondents' approaches to the manuscript option (e.g., number of papers) and advice are summarized. Manuscript option dissertations are commonly offered and provide benefits to students and faculty; however, thoughtful implementation is critical. Programs need to agree upon clear expectations and have graduate school support (e.g., formatting). Faculty need mentorship in advising manuscript option students who choose to use this format, and the time and support. Finally, students need additional writing skills that could be provided through coursework or via individual work with mentors. As nursing education continues to expand further into doctoral research, programs must examine dissertation formats in order to both prepare future nurse scholars and disseminate nursing research that is critical

  1. Cooperation and human development projects as bachelor, master and PhD thesis: evaluating an internship program

    OpenAIRE

    Ferrer Martí, Laia; Garfi, Marianna; Ferrer Martí, Ivet

    2015-01-01

    The Research Group on Cooperation and Human Development (GRECDH) of the Technical University of Catalonia (UPC) has long promoted Bachelor, Master and PhD Theses in the framework of sustainable energy projects in low income countries. In this way, students combine their work at UPC with tasks in these countries. The aim of this paper is to present and evaluate the program through the experience of several students who participated in sustainable energy projects in Central and South America.

  2. Industrial Ph.D. Programs for the Strengthening of the Industry’s Production of Innovation in Colombia

    Directory of Open Access Journals (Sweden)

    Jorge Celis

    2016-09-01

    Full Text Available Today’s firms face a new global economy powered by knowledge rather than physical resources and natural raw materials. Universities are crucial actors in ensuring economic development, not only by training highly qualified human capital, but also by producing new knowledge with innovation potential. University–industry research collaborations (UICs have been increaingly recognized as an innovation mode. Highly qualified people, mainly at Ph.D. level, are fundamental for the increase of the knowledge pool from which firms and society as a whole can benefit in terms of the production of innovation. The demand for more specialized researchers in business/industry has led to new versions of doctoral programs, such as Industrial Ph.D. Programs (IPPs, which are well-established in a number of countries. After using an analytical international and comparative education methodology, we have found that the cooperation with industry to develop Ph.D. programs in Colombia is relatively weak and requires to be enhanced. In this paper, we argue for the alignment of the so-called third academic mission of economic development with the traditional academic missions of teaching and research through the implementation of IPPs as a mechanism for strengthening the innovation process of firms and country’s economic growth.

  3. Using Communicative Action Theory to Analyse Relationships Between Supervisors and Phd Students in a Technical University in Sweden

    Directory of Open Access Journals (Sweden)

    Michael Christie

    2013-04-01

    Full Text Available In this paper the authors use the theory of communicative action (Habermas, 1984-6 to analyse problematic relationships that can occur between supervisors and PhD students, between co-supervisors and between the students themselves. In a situation where power is distributed unequally, instrumental and strategic action on the part of either party can complicate and disturb efficacious relationships. We use Flanagan’s critical incident technique (Flanagan, 1954 to analyse twenty-five incidents that are told from a supervisor perspective and twentyfive from a PhD student perspective. The analysis reveals that a large proportion of incidents involved power struggles. Other categories include lack of professional or emotional support and poor communication. Rational dialogue based on Habermasian principles might have avoided many of these problems. The analysis concludes with some practical suggestions as to how the use of communicative action theory and critical incident technique can improve supervision, supervision training and the PhD process.

  4. The PHD Domain of Np95 (mUHRF1) Is Involved in Large-Scale Reorganization of Pericentromeric Heterochromatin

    Science.gov (United States)

    Papait, Roberto; Pistore, Christian; Grazini, Ursula; Babbio, Federica; Cogliati, Sara; Pecoraro, Daniela; Brino, Laurent; Morand, Anne-Laure; Dechampesme, Anne-Marie; Spada, Fabio; Leonhardt, Heinrich; McBlane, Fraser; Oudet, Pierre

    2008-01-01

    Heterochromatic chromosomal regions undergo large-scale reorganization and progressively aggregate, forming chromocenters. These are dynamic structures that rapidly adapt to various stimuli that influence gene expression patterns, cell cycle progression, and differentiation. Np95-ICBP90 (m- and h-UHRF1) is a histone-binding protein expressed only in proliferating cells. During pericentromeric heterochromatin (PH) replication, Np95 specifically relocalizes to chromocenters where it highly concentrates in the replication factories that correspond to less compacted DNA. Np95 recruits HDAC and DNMT1 to PH and depletion of Np95 impairs PH replication. Here we show that Np95 causes large-scale modifications of chromocenters independently from the H3:K9 and H4:K20 trimethylation pathways, from the expression levels of HP1, from DNA methylation and from the cell cycle. The PHD domain is essential to induce this effect. The PHD domain is also required in vitro to increase access of a restriction enzyme to DNA packaged into nucleosomal arrays. We propose that the PHD domain of Np95-ICBP90 contributes to the opening and/or stabilization of dense chromocenter structures to support the recruitment of modifying enzymes, like HDAC and DNMT1, required for the replication and formation of PH. PMID:18508923

  5. Genome-Wide Identification of the PHD-Finger Family Genes and Their Responses to Environmental Stresses in Oryza sativa L.

    Science.gov (United States)

    Sun, Mingzhe; Yang, Junkai; Cui, Na; Zhu, Yanming

    2017-01-01

    The PHD-finger family has been demonstrated to be involved in regulating plant growth and development. However, little information is given for its role in environmental stress responses. Here, we identified a total of 59 PHD family genes in the rice genome. These OsPHDs genes were located on eleven chromosomes and synteny analysis only revealed nine duplicated pairs within the rice PHD family. Phylogenetic analysis of all OsPHDs and PHDs from other species revealed that they could be grouped into two major clusters. Furthermore, OsPHDs were clustered into eight groups and members from different groups displayed a great divergence in terms of gene structure, functional domains and conserved motifs. We also found that with the exception of OsPHD6, all OsPHDs were expressed in at least one of the ten tested tissues and OsPHDs from certain groups were expressed in specific tissues. Moreover, our results also uncovered differential responses of OsPHDs expression to environmental stresses, including ABA (abscisic acid), water deficit, cold and high Cd. By using quantitative real-time PCR, we further confirmed the differential expression of OsPHDs under these stresses. OsPHD1/7/8/13/33 were differentially expressed under water deficit and Cd stresses, while OsPHD5/17 showed altered expression under water deficit and cold stresses. Moreover, OsPHD3/44/28 displayed differential expression under ABA and Cd stresses. In conclusion, our results provide valuable information on the rice PHD family in plant responses to environmental stress, which will be helpful for further characterizing their biological roles in responding to environmental stresses.

  6. English summary of chapters in PhD Thesis 'Landscape transformations. A new paradigm for working with the synergy of physical and abstract landscapes

    DEFF Research Database (Denmark)

    Munck Petersen, Rikke

    2011-01-01

    English summary of chapters in PhD Thesis 'Landscape transformations. A new paradigm for working with the synergy of physical and abstract landscapes in relation to the ICAR-CORA Prize 2011......English summary of chapters in PhD Thesis 'Landscape transformations. A new paradigm for working with the synergy of physical and abstract landscapes in relation to the ICAR-CORA Prize 2011...

  7. QGIS TimeManager and how the QGIS community helped me make a great leap forward in visualizing tracking data for my PhD project

    DEFF Research Database (Denmark)

    Nielsen, Søren Zebitz

    2015-01-01

    This blog post is the story how collaboration with the QGIS developer community made me able to produce some much needed visualizations of pedestrian tracking data for my ongoing PhD project.......This blog post is the story how collaboration with the QGIS developer community made me able to produce some much needed visualizations of pedestrian tracking data for my ongoing PhD project....

  8. Changes in Hypoxia-Inducible Factor-1 (HIF-1) and Regulatory Prolyl Hydroxylase (PHD) Enzymes Following Hypoxic-Ischemic Injury in the Neonatal Rat.

    Science.gov (United States)

    Chu, Hannah X; Jones, Nicole M

    2016-03-01

    Hypoxia leads to activation of many cellular adaptive processes which are regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1). HIF-1 consists of HIF-1α and HIF-1ß subunits and levels of HIF-1α protein are regulated by HIF prolyl-hydroxylase enzymes (PHD1, 2, 3). The aim of the current study was to investigate the expression of HIF-1α and PHDs at various time points after hypoxia-ischemia (HI), using a neonatal rat model of HI brain injury. Sprague-Dawley rat pups (postnatal day 7) were anaesthetized and underwent right carotid artery occlusion and were then exposed to 6 % oxygen for 2.5 h at 37 °C. HI injured animals demonstrated a significant reduction in the size of the ipsilateral hemisphere, compared to sham controls. Protein analysis using western blotting and enzyme-linked immunosorbent assay showed that 24 h after HI, there was a significant increase in PHD3 protein and an increase of HIF-1α compared to controls. At the 72 h time point, there was a reduction in PHD3 protein, which appeared to relate to cellular loss. There were no changes in PHD1 or PHD2 protein levels after HI when compared to age-matched controls. Further studies are necessary to establish roles for the HIF-1 regulatory enzyme PHD3 in brain injury processes.

  9. To make a kick start together – A PhD course co-developed by librarians and professors

    Directory of Open Access Journals (Sweden)

    Ann-Sofie Zettergren

    2013-12-01

    Full Text Available This paper presents a PhD-course called "Kick start to academic life - Information Management and Publication Process for Social Scientists", a collaboration between the Social Sciences Faculty Library at Lund University and professors at the Faculty. The objective of the course is to provide PhD candidates with generic knowledge about how to effectively conduct their PhD studies when it comes to information management and the publication processes. The course combines an introduction to the process of managing one's need of information as a PhD student, and an introduction to the process of managing the publication of one's results. The librarians have been involved in the development of this PhD course, from the first idea of a course in generic competences and on to the actual implementation. The Faculty of Social Science came up with the idea of a course like this in 2009, and asked two teachers/professors and two librarians to make an outline. We choose to focus on students in the beginning of their PhD studies, who would benefit most from it. We have now run it for 3 years (2010-2012, developed the course as for content and size, from demands from students and faculty as well as from our own experiences. Designing the course together, librarians and professors gained an insight into each other's competences and area of expertise. We used previous experiences from working with PhD students, like the providing of shorter courses, seminars and workshops. We choose a course design mixing lectures and workshops, in order to make the course both theoretical and practical. The course design also helped emphasizing aspects of the subject being discussed. One example is by adding a practical workshop in reference management program given by the librarians just after a lecture given by a professor about how and why academics cite. Another example is when we invite an editor of a high ranked peer-reviewed journal to talk about article submission from

  10. Down-regulation of GRP78 is associated with the sensitivity of chemotherapy to VP-16 in small cell lung cancer NCI-H446 cells

    International Nuclear Information System (INIS)

    Wang, Yingyan; Wang, Wei; Wang, Siyan; Wang, Jiarui; Shao, Shujuan; Wang, Qi

    2008-01-01

    Chemotherapy resistance remains a major obstacle for the treatment of small cell lung cancer (SCLC). Glucose-regulated protein 78 (GRP78), an endoplasmic reticulum chaperone, plays a critical role in chemotherapy resistance in some cancers. However, whether the suppression of the chaperone can enhance the sensitivity of chemotherapy in SCLC is still unclear. The SCLC NCI-H446 cells were divided into three groups: BAPTA-AM→A23187-treated group, A23187-treated group and control-group. Immunofluorescence, western blot and RT-PCR were used to assess the expression of GRP78 at both protein and mRNA levels. Cell apoptosis and the cell cycle distributions of the cells were analyzed by flow cytometry in order to evaluate the therapeutic sensitivity to VP-16. The expression of GRP78 at both protein and mRNA levels in the BAPTA-AM→A23187-treated cells dramatically decreased as compared to that in both A23187-treated and control groups. After treatment by VP-16, the percentage of apoptotic cells in BAPTA-AM→A23187-treated cells were: 33.4 ± 1.01%, 48.2 ± 1.77%, 53.0 ± 1.43%, 56.5 ± 2.13%, respectively, corresponding to the concentrations of BAPTA-AM 10, 15, 25, 40 μM, which was statistically significant high in comparison with the A23187-treated group and untreated-group (7.18 ± 1.03% and 27.8 ± 1.45%, respectively, p < 0.05). The results from analysis of cell cycle distribution showed that there was a significantly decreased in G 1 phase and a dramatically increased in S phase for the BAPTA-AM→A23187-treated cells as compared with the untreated cells. BAPTA-AM is a strong inhibitor of GRP78 in the NCI-H446 cell line, the down-regulation of GRP78 can significantly increase the sensitivity to VP-16. The suppression of GRP78 may offer a new surrogated therapeutic approach to the clinical management of lung cancer

  11. Esters of Quinoxaline 1ˏ4-Di-N-oxide with Cytotoxic Activity on Tumor Cell Lines Based on NCI-60 Panel

    Science.gov (United States)

    Rivera, Gildardo; Ahmad Shah, Syed Shoaib; Arrieta-Baez, Daniel; Palos, Isidro; Mongue, Antonio; Sánchez-Torres, Luvia Enid

    2017-01-01

    Quinoxalines display diverse and interesting pharmacological activities as antibacterial, antiviral, antiparasitic and anticancer agents. Particularly, their 1ˏ4-di-N-oxide derivatives have proved to be cytotoxic agents that are active under hypoxic conditions as that of solid tumours. A new series of quinoxaline 1ˏ4-di-N-oxide substitutes at 7-position with esters group were synthetized and characterized by infrared (IR), proton nuclear magnetic resonance (1H-NMR), spectroscopy, and elemental analysis. Seventeen derivatives (M1-M3, E1-E8, P1-P3 and DR1-DR3) were selected and evaluated for antitumor activities using the NCI-60 human tumor cell lines screen. Results showed that E7, P3 and E6 were the most active compounds against the cell lines tested. Substitutions at 7-position with esters group not necessarily affect the biological activity, but the nature of the esters group could exert an influence on the selectivity. Additionally, substitutions at 2-position influenced the cytotoxic activity of the compounds. PMID:29201086

  12. Regulation of voltage-gated potassium channels attenuates resistance of side-population cells to gefitinib in the human lung cancer cell line NCI-H460.

    Science.gov (United States)

    Choi, Seon Young; Kim, Hang-Rae; Ryu, Pan Dong; Lee, So Yeong

    2017-02-21

    Side-population (SP) cells that exclude anti-cancer drugs have been found in various tumor cell lines. Moreover, SP cells have a higher proliferative potential and drug resistance than main population cells (Non-SP cells). Also, several ion channels are responsible for the drug resistance and proliferation of SP cells in cancer. To confirm the expression and function of voltage-gated potassium (Kv) channels of SP cells, these cells, as well as highly expressed ATP-binding cassette (ABC) transporters and stemness genes, were isolated from a gefitinib-resistant human lung adenocarcinoma cell line (NCI-H460), using Hoechst 33342 efflux. In the present study, we found that mRNA expression of Kv channels in SP cells was different compared to Non-SP cells, and the resistance of SP cells to gefitinib was weakened with a combination treatment of gefitinib and Kv channel blockers or a Kv7 opener, compared to single-treatment gefitinib, through inhibition of the Ras-Raf signaling pathway. The findings indicate that Kv channels in SP cells could be new targets for reducing the resistance to gefitinib.

  13. Design of Phase I Combination Trials: Recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee

    Science.gov (United States)

    Paller, Channing J.; Bradbury, Penelope A.; Ivy, S. Percy; Seymour, Lesley; LoRusso, Patricia M.; Baker, Laurence; Rubinstein, Larry; Huang, Erich; Collyar, Deborah; Groshen, Susan; Reeves, Steven; Ellis, Lee M.; Sargent, Daniel J.; Rosner, Gary L.; LeBlanc, Michael L.; Ratain, Mark J.

    2014-01-01

    Anticancer drugs are combined in an effort to treat a heterogeneous tumor or to maximize the pharmacodynamic effect. The development of combination regimens, while desirable, poses unique challenges. These include the selection of agents for combination therapy that may lead to improved efficacy while maintaining acceptable toxicity, the design of clinical trials that provide informative results for individual agents and combinations, and logistical and regulatory challenges. The phase 1 trial is often the initial step in the clinical evaluation of a combination regimen. In view of the importance of combination regimens and the challenges associated with developing them, the Clinical Trial Design (CTD) Task Force of the National Cancer Institute (NCI) Investigational Drug Steering Committee developed a set of recommendations for the phase 1 development of a combination regimen. The first two recommendations focus on the scientific rationale and development plans for the combination regimen; subsequent recommendations encompass clinical design aspects. The CTD Task Force recommends that selection of the proposed regimens be based on a biological or pharmacological rationale supported by clinical and/or robust and validated preclinical evidence, and accompanied by a plan for subsequent development of the combination. The design of the phase 1 clinical trial should take into consideration the potential pharmacokinetic and pharmacodynamic interactions as well as overlapping toxicity. Depending on the specific hypothesized interaction, the primary endpoint may be dose optimization, pharmacokinetics, and/or pharmacodynamic (i.e., biomarker). PMID:25125258

  14. Hexamethoxylated Monocarbonyl Analogues of Curcumin Cause G2/M Cell Cycle Arrest in NCI-H460 Cells via Michael Acceptor-Dependent Redox Intervention.

    Science.gov (United States)

    Li, Yan; Zhang, Li-Ping; Dai, Fang; Yan, Wen-Jing; Wang, Hai-Bo; Tu, Zhi-Shan; Zhou, Bo

    2015-09-09

    Curcumin, derived from the dietary spice turmeric, holds promise for cancer prevention. This prompts much interest in investigating the action mechanisms of curcumin and its analogues. Two symmetrical hexamethoxy-diarylpentadienones (1 and 2) as cucumin analogues were reported to possess significantly enhanced cytotoxicity compared with the parent molecule. However, the detailed mechanisms remain unclear. In this study, compounds 1 and 2 were identified as the G2/M cell cycle arrest agents to mediate the cytotoxicity toward NCI-H460 cells via Michael acceptor-dependent redox intervention. Compared with curcumin, they could more easily induce a burst of reactive oxygen species (ROS) and collapse of the redox buffering system. One possible reason is that they could more effectively target intracellular TrxR to convert this antioxidant enzyme into a ROS promoter. Additionally, they caused up-regulation of p53 and p21 and down-regulation of redox-sensitive Cdc25C along with cyclin B1/Cdk1 in a Michael acceptor- and ROS-dependent fashion. Interestingly, in comparison with compound 2, compound 1 displayed a relatively weak ability to generate ROS but increased cell cycle arrest activity and cytotoxicity probably due to its Michael acceptor-dependent microtubule-destabilizing effect and greater GST-inhibitory activity, as well as its enhanced cellular uptake. This work provides useful information for understanding Michael acceptor-dependent and redox-mediated cytotoxic mechanisms of curcumin and its active analogues.

  15. MS PHD'S: A Successful Model Promoting Inclusion, Preparation and Engagement of Underrepresented Minorities within the Geosciences Workforce

    Science.gov (United States)

    Padilla, E.; Scott, O.; Strickland, J. T.; Ricciardi, L.; Guzman, W. I.; Braxton, L.; Williamson, V.; Johnson, A.

    2015-12-01

    According to 2014 findings of the National Research Council, geoscience and related industries indicate an anticipated 48,000 blue-collar, scientific, and managerial positions to be filled by underrepresented minority (URM) workers in the next 15 years. An Information Handling Services (IHS) report prepared for the American Petroleum Institute forecasts even greater numbers estimating upward of 408,000 opportunities for URM workers related to growth in accelerated development of oil, gas and petroleum industries. However, many URM students lack the training in both the hard sciences and craft skills necessary to fill these positions. The Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S) Professional Development Program uses integrative and holistic strategies to better prepare URM students for entry into all levels of the geoscience workforce. Through a three-phase program of mentoring, community building, networking and professional development activities, MS PHD'S promotes collaboration, critical thinking, and soft skills development for participants. Program activities expose URM students to education, training and real-life geoscience workforce experiences while maintaining a continuity of supportive mentoring and training networks via an active virtual community. MS PHD'S participants report increased self-confidence and self-efficacy in pursuing geoscience workforce goals. To date, the program supports 223 participants of who 57, 21 and 16 have received Doctorate, Masters and Baccalaureate degrees respectively and are currently employed within the geoscience and related industries workforce. The remaining 129 participants are enrolled in undergraduate and graduate programs throughout the U.S. Geographic representation of participants includes 35 states, the District of Columbia, Puerto Rico and two international postdoctoral appointments - one in Saudi Arabia and the other in France.

  16. The impact of teaching experience on interview performance of different candidates of basic medical sciences in PhD admission.

    Science.gov (United States)

    Mehridehnavi, Alireza

    2015-01-01

    Admission includes written and interview at universities belonging to the ministry of the health and medical education of Iran at PhD level. In the present work, it was tried to find out the likelihood of interview performance of different candidates with their teaching experience in Iranian national medical PhD admission in the year 1386-87. In this study, applicants' exam results were extracted from their score workbooks for year 86-87. PhD applicants' categories were public (ordinary) and employed lecturers. Invited numbers of candidates for interview were 556 from 29 different fields of study. As the number of written subjects were not the same within different fields of study, at the first, each group score distribution were normalized to one and then combined together for final consideration. Accept and reject percentage within public applicants were 45.1 and 54.9, respectively, while the accept percentage within lecturer applicants was 66 and the reject was 34 respectively. Scores of all 29 groups were combined after normalization. The overall performance including test plus interview for public and lecturers were 1.02 ± 0.12 and 0.95 ± 0.1, respectively. The average and standard deviation of test exam of public and lecturer were 1.04 ± 0.16 and 0.91 ± 0.12, respectively. The average and standard deviation of interview exam of public applicants and lecturers applicants were 0.98 ± 0.18 and 1.04 ± 0.17, respectively. As results show, the interview performance of lecturers is better than public applicants. Unbalanced acceptance rate amongst lecturers was increased due to the hold of reservation toward interview and due to their higher results gain during interview. If the test performance was a reliable measure for viability of applicant, this reservation would change the acceptance rate close to balance.

  17. MS PHD'S PDP: Vision, Design, Implementation, and Outcomes of a Minority-Focused Earth System Sciences Program

    Science.gov (United States)

    Habtes, S. Y.; Mayo, M.; Ithier-Guzman, W.; Pyrtle, A. J.; Williamson Whitney, V.

    2007-05-01

    As minorities are predicted to comprise at least 33% of the US population by the year 2010, their representation in the STEM fields, including the ocean sciences, is still poorly established. In order to advance the goal of better decision making, the Ocean Sciences community must achieve greater levels of diversity in membership. To achieve this objective of greater diversity in the sciences, the Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science® Professional Development Program (MS PHD'S PDP), which was launched in 2003, is supported via grants from NASA's Office of Earth Science, and NSF's Directorate for Geosciences. The MS PHD'S PDP is designed to provide professional and mentoring experiences that facilitate the advancement of minorities committed to achieving outstanding Earth System Science careers. The MS PHD'S PDP is structured in three phases, connected by engagement in a virtual community, continuous peer and mentor to mentee interactions, and the professional support necessary for ensuring the educational success of the student participants. Since the pilot program in 2003, the MSPHD'S PDP, housed at the University of South Florida's College of Marine Science, has produced 4 cohorts of students. Seventy-five have completed the program; of those 6 have earned their doctoral degrees. Of the 45 current participants 10 are graduate students in Marine Science and 15 are still undergraduates, the remaining 10 participants are graduate students in other STEM fields. Since the implementation of the MSPHD'S PDP a total of 87 students and 33 scientist mentors have become part of the MSPHD'S virtual community, helping to improve the learning environment for current and future participants as well as build a community of minority students that encourages each other to pursue their academic degrees.

  18. Simulation programs for ph.D. study of analysis, modeling and optimum design of solar domestic hot water systems

    Energy Technology Data Exchange (ETDEWEB)

    Lin Qin

    1998-12-31

    The design of solar domestic hot water (DHW) systems is a complex process, due to characteristics inherent in the solar heating technology. Recently, computer simulation has become a widely used technique to improve the understanding of the thermal processes in such systems. One of the main objects of the Ph.D. study of `Analysis, Modelling and optimum Design of Solar Domestic Hot Water Systems` is to develop and verify programs for carrying out the simulation and evaluation of the dynamic performance of solar DHW systems. During this study, simulation programs for hot water distribution networks and for certain types of solar DHW systems were developed. (au)

  19. Something going on in Milan: a review of the 4th International PhD Student Cancer Conference.

    Science.gov (United States)

    Segré, C

    2010-01-01

    The 4th International PhD Student Cancer Conference was held at the IFOM-IEO-Campus in Milan from 19-21 May 2010 http://www.semm.it/events_researchPast.phpThe Conference covered many topics related to cancer, from basic biology to clinical aspects of the disease. All attendees presented their research, by either giving a talk or presenting a poster. This conference is an opportunity to introduce PhD students to top cancer research institutes across Europe.THE CORE PARTICIPANTING INSTITUTES INCLUDED: European School of Molecular Medicine (SEMM)-IFOM-IEO Campus, MilanBeatson Institute for Cancer Research (BICR), GlasgowCambridge Research Institute (CRI), Cambridge, UKMRC Gray Institute of Radiation Biology (GIROB), OxfordLondon Research Institute (LRI), LondonPaterson Institute for Cancer Research (PICR), ManchesterThe Netherlands Cancer Institute (NKI), Amsterdam'You organizers have crushed all my prejudices towards Italians. Congratulations, I enjoyed the conference immensely!' Even if it might have sounded like rudeness for sure this was supposed to be a genuine compliment (at least, that's how we took it), also considering that it was told by a guy who himself was the fusion of two usually antithetical concepts: fashion style and English nationality.The year 2010 has marked an important event for Italian research in the international scientific panorama: the European School of Molecular Medicine (SEMM) had the honour to host the 4th International PhD Student Cancer Conference, which was held from 19-21 May 2010 at the IFOM-IEO-Campus (http://www.semm.it/events_researchPast.php) in Milan.The conference was attended by more than one hundred students, coming from a selection of cutting edge European institutes devoted to cancer research. The rationale behind it is the promotion of cooperation among young scientists across Europe to debate about science and to exchange ideas and experiences. But that is not all, it is also designed for PhD students to get in touch

  20. The experience of international nursing students studying for a PhD in the U.K: A qualitative study.

    Science.gov (United States)

    Evans, Catrin; Stevenson, Keith

    2011-06-13

    Educating nurses to doctoral level is an important means of developing nursing capacity globally. There is an international shortage of doctoral nursing programmes, hence many nurses seek their doctorates overseas. The UK is a key provider of doctoral education for international nursing students, however, very little is known about international doctoral nursing students' learning experiences during their doctoral study. This paper reports on a national study that sought to investigate the learning expectations and experiences of overseas doctoral nursing students in the UK. Semi-structured qualitative interviews were conducted in 2008/09 with 17 international doctoral nursing students representing 9 different countries from 6 different UK universities. Data were analysed thematically. All 17 interviewees were enrolled on 'traditional' 3 year PhD programmes and the majority (15/17) planned to work in higher education institutions back in their home country upon graduation. Studying for a UK PhD involved a number of significant transitions, including adjusting to a new country/culture, to new pedagogical approaches and, in some cases, to learning in a second language. Many students had expected a more structured programme of study, with a stronger emphasis on professional nursing issues as well as research - akin to the professional doctorate. Students did not always feel well integrated into their department's wider research environment, and wanted more opportunities to network with their UK peers. A good supervision relationship was perceived as the most critical element of support in a doctoral programme, but good relationships were sometimes difficult to attain due to differences in student/supervisor expectations and in approaches to supervision. The PhD was perceived as a difficult and stressful journey, but those nearing the end reflected positively on it as a life changing experience in which they had developed key professional and personal skills. Doctoral

  1. The experience of international nursing students studying for a PhD in the U.K: A qualitative study

    Directory of Open Access Journals (Sweden)

    Stevenson Keith

    2011-06-01

    Full Text Available Abstract Background Educating nurses to doctoral level is an important means of developing nursing capacity globally. There is an international shortage of doctoral nursing programmes, hence many nurses seek their doctorates overseas. The UK is a key provider of doctoral education for international nursing students, however, very little is known about international doctoral nursing students' learning experiences during their doctoral study. This paper reports on a national study that sought to investigate the learning expectations and experiences of overseas doctoral nursing students in the UK. Methods Semi-structured qualitative interviews were conducted in 2008/09 with 17 international doctoral nursing students representing 9 different countries from 6 different UK universities. Data were analysed thematically. All 17 interviewees were enrolled on 'traditional' 3 year PhD programmes and the majority (15/17 planned to work in higher education institutions back in their home country upon graduation. Results Studying for a UK PhD involved a number of significant transitions, including adjusting to a new country/culture, to new pedagogical approaches and, in some cases, to learning in a second language. Many students had expected a more structured programme of study, with a stronger emphasis on professional nursing issues as well as research - akin to the professional doctorate. Students did not always feel well integrated into their department's wider research environment, and wanted more opportunities to network with their UK peers. A good supervision relationship was perceived as the most critical element of support in a doctoral programme, but good relationships were sometimes difficult to attain due to differences in student/supervisor expectations and in approaches to supervision. The PhD was perceived as a difficult and stressful journey, but those nearing the end reflected positively on it as a life changing experience in which they had

  2. Identifying most important skills for PhD students in Food Science and Technology: a comparison between industry and academic stakeholders

    Directory of Open Access Journals (Sweden)

    Chelo González-Martínez

    2015-10-01

    Full Text Available Nowadays, there is an increasing need of new skills for PhD students to face the future labour market prospects. PhD graduates must have qualities attractive not only in academia but also outside, in both manufacture and service-oriented enterprises, in small innovative companies, and in the civil services and public administration, among others. To know what the needs of these future employees are, is of great importance to be able to improve their personal and academic formation. The aim of this work was, in the framework of the EC-funded ISEKI_Food 4 network, to evaluate the most desirable specific and soft skills that PhD students should acquire by the end of their doctoral studies. To this aim, several surveys were conducted and sent to the different stakeholders (academia and food industry partners in order to collect the information needed. Results showed that competences related to research skills and techniques, research management, personal effectiveness and communication skills were considered to be the most valuable skills to be acquired by our PhD students to meet the future needs of the labour market.  The importance of these skills was appreciated differently, depending on the stakeholder. To sum up, some recommendations to integrate such valuable skills into the curricula of the PhD student are given.

  3. Harnessing the power of communities: career networking strategies for bioscience PhD students and postdoctoral researchers.

    Science.gov (United States)

    Blackford, Sarah

    2018-04-01

    With an ever more competitive global labour market, coupled with an ever-increasing population of PhD-qualified graduates, the ability to communicate effectively and build strategic connections with others can be advantageous in the job-search process. Whether in pursuit of a tenure-track or non-academic position, many postdoctoral researchers and PhD students will benefit from networking as early as possible to enhance their career prospects. Sometimes viewed cynically as 'using people' or dismissed as 'the old boy network,' the ability to make meaningful connections and build relationships can be more valuable than other job-related skills in order to gain entry to, and progress within, many professions. This mini-review highlights the positive influence of networking and how bioscience PhD students and postdoctoral researchers can harness the power of communities to achieve career success. It is argued that those who make connections and promote personal patronage through networking can gain an advantage over their contemporaries. A summary of key theories and research studies that underpin the practice of networking provides credence to these assertions, which are further substantiated with examples pertinent to the academic community. Although primarily focussed on the biosciences, much of the content is applicable to other scientists at a similar career stage.

  4. Oral biology in middle age: a history of the University at Buffalo Oral Biology PhD Program.

    Science.gov (United States)

    Scannapieco, F A

    2014-05-01

    In 1960, the first Department of Oral Biology in the United States dedicated to the conduct of research, graduate biomedical research education, and the provision of basic oral science education for the DDS curriculum was established at the University at Buffalo. In 1963, the Department organized the first PhD Program in Oral Biology in the United States. This PhD program has produced a large cadre of oral health researchers, many of whom have gone on to make major contributions to dental research and education. This article provides a brief history of the program, the context within which the program was organized and developed, and a description of some of the many faculty, students, and fellows associated with the program. Additionally, to celebrate the 50th anniversary of this program, a symposium, entitled "The Oral Microbiome, Immunity and Chronic Disease", was held on June 12-14, 2013, in Buffalo, New York. The proceedings are published online in Advances in Dental Research (2014, Vol. 26).

  5. Spanish production of PhD Thesis in the field of guidance on TESEO database (2001-2012

    Directory of Open Access Journals (Sweden)

    Ferreira-Villa, Camino

    2013-04-01

    Full Text Available The objective of this research is to analyse the scientific production in PhD Thesis about guidance in Spain from 2001 to 2012. The data have been recollected on the TESEO database belonging to the Ministry of Education, Culture and Sport. It has realized a content analysis of the titles, keywords and abstracts and it has assessed of them their productivity, the general and methodological features and the subjects that have been studied. It has been obtained ninety PhD Thesis in relation to the field of guidance over the last ten years that have studied mainly curriculum and career development. El objetivo de este estudio es analizar la producción científica en Tesis Doctorales sobre orientación en España entre 2001 y 2012. Los datos han sido recogidos a través de la Base de datos TESEO del Ministerio de Educación, Cultura y Deporte. Se ha realizado un análisis de contenido de los títulos, descriptores y resúmenes, valorando la productividad del área, las principales características generales y metodológicas y las temáticas estudiadas. Se han obtenido noventa Tesis Doctorales relacionadas con el ámbito de la orientación en los últimos diez años que han estudiado principalmente aspectos sobre el currículum y el desarrollo vocacional.

  6. Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training.

    Science.gov (United States)

    Goldberg, Charles; Insel, Paul A

    2013-06-01

    Many aspects of MD-PhD training are not optimally designed to prepare students for their future roles as translational clinician-scientists. The transition between PhD research efforts and clinical rotations is one hurdle that must be overcome. MD-PhD students have deficits in clinical skills compared with those of their MD-only colleagues at the time of this transition. Reimmersion programs (RPs) targeted to MD-PhD students have the potential to help them navigate this transition.The authors draw on their experience creating and implementing an RP that incorporates multiple types of activities (clinical exam review, objective structured clinical examination, and supervised practice in patient care settings) designed to enhance the participants' skills and readiness for clinical efforts. On the basis of this experience, they note that MD-PhD students' time away from the clinical environment negatively affects their clinical skills, causing them to feel underprepared for clinical rotations. The authors argue that participation in an RP can help students feel more comfortable speaking with and examining patients and decrease their anxiety regarding clinical encounters. The authors propose that RPs can have positive outcomes for improving the transition from PhD to clinical MD training in dual-degree programs. Identifying and addressing this and other transitions need to be considered to improve the educational experience of MD-PhD students.

  7. Too Many PhD Graduates or Too Few Academic Job Openings: The Basic Reproductive Number R0 in Academia.

    Science.gov (United States)

    Larson, Richard C; Ghaffarzadegan, Navid; Xue, Yi

    2014-01-01

    The academic job market has become increasingly competitive for PhD graduates. In this note, we ask the basic question of 'Are we producing more PhDs than needed?' We take a systems approach and offer a 'birth rate' perspective: professors graduate PhDs who later become professors themselves, an analogue to how a population grows. We show that the reproduction rate in academia is very high. For example, in engineering, a professor in the US graduates 7.8 new PhDs during his/her whole career on average, and only one of these graduates can replace the professor's position. This implies that in a steady state, only 12.8% of PhD graduates can attain academic positions in the USA. The key insight is that the system in many places is saturated, far beyond capacity to absorb new PhDs in academia at the rates that they are being produced. Based on the analysis, we discuss policy implications.

  8. The UF/NCI family of hybrid computational phantoms representing the current US population of male and female children, adolescents, and adults—application to CT dosimetry

    International Nuclear Information System (INIS)

    Geyer, Amy M; O'Reilly, Shannon; Long, Daniel J; Bolch, Wesley E; Lee, Choonsik

    2014-01-01

    Substantial increases in pediatric and adult obesity in the US have prompted a major revision to the current UF/NCI (University of Florida/National Cancer Institute) family of hybrid computational phantoms to more accurately reflect current trends in larger body morphometry. A decision was made to construct the new library in a gridded fashion by height/weight without further reference to age-dependent weight/height percentiles as these become quickly outdated. At each height/weight combination, circumferential parameters were defined and used for phantom construction. All morphometric data for the new library were taken from the CDC NHANES survey data over the time period 1999–2006, the most recent reported survey period. A subset of the phantom library was then used in a CT organ dose sensitivity study to examine the degree to which body morphometry influences the magnitude of organ doses for patients that are underweight to morbidly obese in body size. Using primary and secondary morphometric parameters, grids containing 100 adult male height/weight bins, 93 adult female height/weight bins, 85 pediatric male height/weight bins and 73 pediatric female height/weight bins were constructed. These grids served as the blueprints for construction of a comprehensive library of patient-dependent phantoms containing 351 computational phantoms. At a given phantom standing height, normalized CT organ doses were shown to linearly decrease with increasing phantom BMI for pediatric males, while curvilinear decreases in organ dose were shown with increasing phantom BMI for adult females. These results suggest that one very useful application of the phantom library would be the construction of a pre-computed dose library for CT imaging as needed for patient dose-tracking. (paper)

  9. NCI calculations for understanding a physical phase transition in (C6H14N2)[Mn(H2O)6](SeO4)2

    Science.gov (United States)

    Naïli, Houcine; François, Michel; Norquist, Alexander J.; Rekik, Walid

    2017-12-01

    An organically templated manganese selenate, (C6H14N2)[Mn(H2O)6](SeO4)2, has been synthesized by slow evaporation and crystallographically characterized. The title compound crystallizes at room temperature in the monoclinic centrosymmetric space group P21/n, with the following unit cell parameters: a = 7.2373(4) Å; b = 12.5600(7) Å; c = 10.1945(7) Å; β = 91.155(4)°, V = 926.50(10) Å3and Z = 2. Its crystal structure is built of manganese(II) cations coordinated by six water molecules in octahedral geometry, disordered dabcodiium cations and selenate anions, resulting in an extensive hydrogen-bonding network. Differential scanning calorimetry (DSC) measurement indicated that the precursor undergoes a reversible phase transition at about 216 and 218 K during the cooling and heating processes respectively. Below this temperature the title compound is noncentrosymmetric with space group P21 and lattice parameters a = 7.2033(8) Å; b = 12.4981(13) Å; c = 10.0888(11) Å; β = 91.281(2)°, V = 908.04(17) Å3 and Z = 2. The disorder-order transformation of the C atoms of (C6H14N2)2+ cation may drive the structural phase transition. The low temperature phase obtained by breaking symmetry presents a fully ordered structure. The noncovalent interaction (NCI) method was used not only to locate, quantify, and visualize intermolecular interactions in the high and low temperature phases but also to confirm the phase transition detected by DSC measurement. The thermal decomposition of this new compound proceeds through four stages giving rise to the manganese oxide as final product at 850 °C.

  10. Erythropoietin inhibits HIF-1α expression via upregulation of PHD-2 transcription and translation in an in-vitro model of hypoxia ischemia

    Science.gov (United States)

    Souvenir, Rhonda; Flores, Jerry J.; Ostrowski, Robert P.; Manaenko, Anatol; Duris, Kamil; Tang, Jiping

    2014-01-01

    Hypoxia inducible factor (HIF)-1α is the central transcriptional factor for the regulation of oxygen-associated genes in response to hypoxia. Erythropoietin (EPO), a hematopoietic growth factor, increases oxygen availability during hypoxia/ischemia and is associated with neuroprotection following hypoxia ischemia in laboratory models of stroke. However, EPO has failed to translate in a clinical setting. Thus it is critical to elucidate the key players in EPO-induced neuroprotection. Our preliminary studies have shown that EPO, as a downstream gene of hypoxia inducible factor (HIF), inhibits HIF-1α in a dose-dependent manner in an in-vitro model of hypoxia ischemia. This study is designed to elucidate the primary mediator of EPO-induced HIF-1α inhibition and subsequent cell survival/neuroprotection. Oxygen and glucose deprivation (OGD) of nerve growth factor (NGF) differentiated rat pheochromocytoma (PC-12) cells were used to model hypoxia ischemia in an in vitro environment. The profile of HIF-1α, HIF-2α and PHD-2 expression, HIF-1α and prolyl hydroxylase (PHD-2) mRNA levels, MMP-9 and cell death was evaluated in the presence and absence of either EPO or PHD-2 inhibitor during OGD. Our findings showed that EPO treatment resulted in an increase in PHD-2 transcription and translation, inhibition of HIF-1α expression, reactive oxygen species (ROS) formation and matrix metalloproteinase (MMP)-9 activity, resulting in increased cell survival after OGD. We also observed that EPO-induced cell survival/neuroprotection was reversed by siRNA silencing of PHD-2. This led to the conclusion that PHD-2 is a key mediator of EPO-induced HIF-1α inhibition and subsequent neuroprotection in an in vitro model of hypoxia ischemia. PMID:24323731

  11. Erythropoietin inhibits HIF-1α expression via upregulation of PHD-2 transcription and translation in an in vitro model of hypoxia-ischemia.

    Science.gov (United States)

    Souvenir, Rhonda; Flores, Jerry J; Ostrowski, Robert P; Manaenko, Anatol; Duris, Kamil; Tang, Jiping

    2014-02-01

    Hypoxia inducible factor (HIF)-1α is the central transcriptional factor for the regulation of oxygen-associated genes in response to hypoxia. Erythropoietin (EPO), a hematopoietic growth factor, increases oxygen availability during hypoxia/ischemia and is associated with neuroprotection following hypoxia-ischemia in laboratory models of stroke. However, EPO has failed to translate in a clinical setting. Thus, it is critical to elucidate the key players in EPO-induced neuroprotection. Our preliminary studies have shown that EPO, as a downstream gene of HIF, inhibits HIF-1α in a dose-dependent manner in an in vitro model of hypoxia-ischemia. This study is designed to elucidate the primary mediator of EPO-induced HIF-1α inhibition and subsequent cell survival/neuroprotection. Oxygen and glucose deprivation (OGD) of nerve growth factor-differentiated rat pheochromocytoma (PC-12) cells were used to model hypoxia-ischemia in an in vitro environment. The profile of HIF-1α, HIF-2α and prolyl hydroxylase domain 2 (PHD-2) expression; HIF-1α and prolyl hydroxylase (PHD-2) mRNA levels; matrix metalloproteinase (MMP)-9; and cell death was evaluated in the presence and absence of either EPO or PHD-2 inhibitor during OGD. Our findings showed that EPO treatment resulted in an increase in PHD-2 transcription and translation, inhibition of HIF-1α expression, reactive oxygen species formation, and MMP-9 activity, resulting in increased cell survival after OGD. We also observed that EPO-induced cell survival/neuroprotection was reversed by siRNA silencing of PHD-2. This led to the conclusion that PHD-2 is a key mediator of EPO-induced HIF-1α inhibition and subsequent neuroprotection in an in vitro model of hypoxia-ischemia.

  12. GRANTS FOR PH.D. STUDENTS ON VSB‐TECHNICAL UNIVERSITY OF OSTRAVA IN THE CZECH REPUBLIC

    Directory of Open Access Journals (Sweden)

    Pavla FOITOVÁ DERNEROVÁ

    2013-07-01

    Full Text Available Projects and grants are unique for development of science and research. For many people it is only source of money for their research. Particularly on universities the projects expanded. From this reason the participation of Ph.D. students in the Student Grant Competition is the best start in this field. Paper discusses in its first part how the Student Grant Competition takes its place on Technical University of Ostrava. Focuses on difficulties with submission of the application, explain process of whole project evaluation and states total amounts acquired from the Ministry of Education, Youth and Sports for Student Grand Competitions since 2010. Second part of this paper directly shows concrete project for “Research of utilization of mining waste in chosen localities.” In the paper is described subject of the research, concrete goals of project, timetable. It is stated the preliminary budget of project and actual progress in the project.

  13. Les experiències artístiques en l'espai públic. Art efímer com a catàlisi de la vida urbana

    Directory of Open Access Journals (Sweden)

    Lucila Urda Peña

    2016-06-01

    Full Text Available L'art efímer urbà, com a corrent d'expressió de pensament col·lectiu és una font de generació de projectes comunitaris en què els ciutadans poden recuperar "l'experiència de ciutat". La profusió de diverses manifestacions d'art efímer en ciutats de tot el món des de començaments del segle XXI està tenint conseqüències en l'espai urbà tant a nivell local com a nivell global. Una d'elles és la transformació del paisatge urbà, cada vegada més considerat com a escenari visible en projectes de regeneració urbana. A més de la transformació física també es produeixen canvis en les dinàmiques urbanes ja que els efectes de les intervencions tenen conseqüències més enllà dels canvis d'imatge. Els efectes socioeconòmics locals o fins i tot globals de les transformacions lligades a l'art efímer són cada vegada més evidents. Aquest article relata l'origen i desenvolupament de diverses manifestacions artístiques urbanes i reflexiona sobre les seves conseqüències en la vida urbana com a eina de transformació física i social.

  14. Presència, tendències i aspectes diferenciadors de la formació sobre drets d'autor en l'alfabetització informacional en l'àmbit universitari

    OpenAIRE

    Uribe Tirado, Alejandro

    2010-01-01

    Objectiu. Analitzar la presència de la temàtica dels drets d'autor, dels aspectes legals de la informació acadèmica i científica, en diferents programes, cursos o programes d'aprenentatge d'alfabetització informacional (ALFIN) de diferents universitats al voltant del món, per identificar les tendències i aspectes diferenciadors que es presenten actualment respecte a la formació en aquestes temàtiques en relació amb la informació digital. També s'analitza com de preparades estan les comunitats...

  15. ChemSession'09 - 6. Warsaw Seminar of the PhD Students in Chemistry - Abstracts; ChemSession'09 - 6. Warszawskie Seminarium Doktorantow Chemikow - Streszczenia

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    Book of Abstracts contains short descriptions of presentations 3 lectures and 105 posters presented during ChemSession'09 - 6{sup th} Warsaw Seminar of the PhD Students in Chemistry. Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also found.

  16. Decoupling of the minority PhD talent pool and assistant professor hiring in medical school basic science departments in the US

    Science.gov (United States)

    Gibbs, Kenneth D; Basson, Jacob; Xierali, Imam M; Broniatowski, David A

    2016-01-01

    Faculty diversity is a longstanding challenge in the US. However, we lack a quantitative and systemic understanding of how the career transitions into assistant professor positions of PhD scientists from underrepresented minority (URM) and well-represented (WR) racial/ethnic backgrounds compare. Between 1980 and 2013, the number of PhD graduates from URM backgrounds increased by a factor of 9.3, compared with a 2.6-fold increase in the number of PhD graduates from WR groups. However, the number of scientists from URM backgrounds hired as assistant professors in medical school basic science departments was not related to the number of potential candidates (R2=0.12, p>0.07), whereas there was a strong correlation between these two numbers for scientists from WR backgrounds (R2=0.48, pprofessors and posited no hiring discrimination. Simulations show that, given current transition rates of scientists from URM backgrounds to faculty positions, faculty diversity would not increase significantly through the year 2080 even in the context of an exponential growth in the population of PhD graduates from URM backgrounds, or significant increases in the number of faculty positions. Instead, the simulations showed that diversity increased as more postdoctoral candidates from URM backgrounds transitioned onto the market and were hired. DOI: http://dx.doi.org/10.7554/eLife.21393.001 PMID:27852433

  17. Toward an Evaluation Framework for Doctoral Education in Social Work: A 10-Year Retrospective of One PhD Program's Assessment Experiences

    Science.gov (United States)

    Bentley, Kia J.

    2013-01-01

    This article presents a framework for evaluation in social work doctoral education and details 10 years of successes and challenges in one PhD program's use of the framework, including planning and implementing specific assessment activities around student learning outcomes and larger program goals. The article argues that a range of…

  18. Implementation of an Education-Focused PhD Program in Anatomy and Cell Biology at Indiana University: Lessons Learned and Future Challenges

    Science.gov (United States)

    Brokaw, James J.; O'Loughlin, Valerie D.

    2015-01-01

    In 2008, the Indiana University School of Medicine, in collaboration with the School of Education, admitted its first student to a newly approved PhD program in Anatomy and Cell Biology focusing on educational research rather than biomedical research. The goal of the program is twofold: (1) to provide students with extensive training in all of the…

  19. Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger

    Institute of Scientific and Technical Information of China (English)

    Chengkun Wang; Jie Shen; Zhongzheng Yang; Ping Chen; Bin Zhao; Wei Hu; Wenxian Lan

    2011-01-01

    Dear Editor,We report two NMR complex structures of PHDUHRF1 binding to unmodified or K9 trimethylated histone tails,which clarify a controversy regarding how the binding of UHRF1 to H3 tails is mediated.Based on our structures,H3R2,not H3K9,mediates PHD binding.

  20. Queueing systems with heavy tails (Summary of Ph.D. thesis on the occasion of receiving the Gijs de Leve prize)

    NARCIS (Netherlands)

    Zwart, A.P.

    2003-01-01

    This article gives a short summary of my PhD thesis Queueing Systems with Heavy-tails, winner of the Gijs De Leve prize for the best Dutch thesis in operations research in the period 2000-2002. Apart from the Gijs de Leve prize, this thesis also received the ASML prize, for best thesis in Ihe