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  1. Forceps Delivery

    Science.gov (United States)

    ... 2015. Related Signs of labor Forceps delivery About Advertisement Mayo Clinic does not endorse companies or products. ... a Job Site Map About This Site Twitter Facebook Google YouTube Pinterest Mayo Clinic is a not- ...

  2. Is it time to rejuvenate the forceps?

    LENUS (Irish Health Repository)

    Talukdar, Sanchila

    2013-08-01

    The obstetric forceps was designed to assist extraction of the foetal head and thereby accomplish delivery of the foetus in the second stage of labour. More than 700 types of obstetric forceps have been described. An understanding of the anatomy of the birth canal and the foetal head is a prerequisite to becoming a skilled and safe user of forceps. Operative vaginal delivery rates have remained stable at between 10 and 13 %. The last few decades has seen a rise in caesarean section, along with the introduction and safe use of the vacuum extractor. This has resulted in a decline both in the use of the obstetric forceps as well as in the training for the same. The forceps is less likely to fail when used as the primary instrument thereby reducing the need for the sequential use of two instruments which increase the morbidity of the neonate. Perineal trauma is more likely to occur with the use of the forceps but the evidence is that the maternal concern is less when compared to the ventouse. Simulation training is an important part of obstetric training. Application of forceps blades in the simulation setting can improve the skill level of obstetricians. The use of the forceps should not be decreasing and more senior involvement in training is necessary so that juniors develop the proper skills to perform forceps delivery in a competent and safe manner. It is vital that the art of the forceps is not lost to future generations of obstetricians and the women they care for.

  3. Bionic forceps for the handling of sensitive tissue

    Directory of Open Access Journals (Sweden)

    Kölle Lucia

    2016-09-01

    Full Text Available Anatomical forceps are used for the handling of sensitive structures in medicine. Structures which are manipulated with these forceps can get damaged or slip out of the grip of the forceps. This paper presents a forceps using the bionic Fin-Ray-Effect inspired by fish-fins in order to handle vulnerable structures in particular. During the process of development, functional models of this forceps were designed, 3D-printed and evaluated.

  4. Biopsy with the new essen biopsy forceps.

    Science.gov (United States)

    Traine, Peter G; Schedler, Katharina J E; Brusa, Mariuccia G S; Rodrigues, Eduardo B

    2013-01-01

    Purpose. To present initial experience with a novel biopsy method, the Essen biopsy forceps. Therefore, two patients with diagnostic suspicion of uveal melanoma underwent biopsy for histopathological confirmation. Case Presentation. Two patients presented with painless unilateral vision reduction. Ultrasound revealed the diagnostic suspicion of uveal melanoma. Therefore, biopsy with the Essen biopsy forceps using a sutureless 23-gauge three-port vitrectomy system was performed. The specimens were then submitted to a pathologist and processed. Histopathology of the obtained specimen confirmed the diagnostic suspicion of choroid melanoma in both patients. Conclusion. Essen biopsy forceps is a very practicable alternative method to the FNAB, allowing a combined histopathological and immunohistochemical examination for achieving high diagnostic accuracy at minimal risk.

  5. Biopsy with the New Essen Biopsy Forceps

    Directory of Open Access Journals (Sweden)

    Peter G. Traine

    2013-01-01

    Full Text Available Purpose. To present initial experience with a novel biopsy method, the Essen biopsy forceps. Therefore, two patients with diagnostic suspicion of uveal melanoma underwent biopsy for histopathological confirmation. Case Presentation. Two patients presented with painless unilateral vision reduction. Ultrasound revealed the diagnostic suspicion of uveal melanoma. Therefore, biopsy with the Essen biopsy forceps using a sutureless 23-gauge three-port vitrectomy system was performed. The specimens were then submitted to a pathologist and processed. Histopathology of the obtained specimen confirmed the diagnostic suspicion of choroid melanoma in both patients. Conclusion. Essen biopsy forceps is a very practicable alternative method to the FNAB, allowing a combined histopathological and immunohistochemical examination for achieving high diagnostic accuracy at minimal risk.

  6. Ultrasound-guided forceps for pleural biopsy

    Directory of Open Access Journals (Sweden)

    Gamal Agmy

    2014-04-01

    Clinical implications: Ultrasound-guided forceps for pleural biopsy can overcome many of the limitations of the conventional needle biopsy procedures, provides multiple biopsy specimens of the parietal pleura that are inaccessible to the biopsy needle, and can be carried out easily and safely even in sick and obese patients. The diagnostic yield is nearly similar to thoracoscopy.

  7. The optimal mechanical efficiency of laparoscopic forceps

    NARCIS (Netherlands)

    Heijnsdijk, E. A. M.; Pasdeloup, A.; Dankelman, J.; Gouma, D. J.

    2004-01-01

    Background Laparoscopic forceps have a large amount of friction in the mechanism, leading to a limited mechanical efficiency, which impairs the pinch force feedback. The advantage of a small amount of friction is that it is easier to maintain a constant pinch force on the tissue. Therefore, to

  8. Forceps delivery at the University College Hospital, Ibadan, Nigeria ...

    African Journals Online (AJOL)

    The incidence of forceps delivery has reduced in Nigeria and in the world in general. Some Obstetricians have not been trained in its use and lack the skill. Objective: To determine the outcome of forceps delivery at this centre. Methodology: A retrospective analysis of all forceps delivery done at this centre between the 1st of ...

  9. Bipolar diathermy forceps with automatic irrigation. Technical note.

    Science.gov (United States)

    Ohta, T; Funatsu, N; Kuroiwa, T; Matsui, T

    1985-06-01

    A method for providing a saline drip during bipolar diathermy is described. Stainless steel tubing is incorporated in both blades of standard bipolar forceps and connected to the irrigating line. Irrigation is started when the forceps are closed and is stopped when they are open.

  10. Comparative Evaluation of Efficacy of Physics Forceps versus Conventional Forceps in Orthodontic Extractions: A Prospective Randomized Split Mouth Study.

    Science.gov (United States)

    Patel, Harsh S; Managutti, Anil M; Menat, Shailesh; Agarwal, Arvind; Shah, Dishan; Patel, Jigar

    2016-07-01

    Tooth extraction is one of the most commonly performed procedures in dentistry. It is usually a traumatic procedure often resulting in immediate destruction and loss of alveolar bone and surrounding soft tissues. Various instruments have been described to perform atraumatic extractions which can prevent damage to the paradental structures. Recently developed physics forceps is one of the instruments which is claimed to perform atraumatic extractions. The aim of the present study was to compare the efficacy of physics forceps with conventional forceps in terms of operating time, prevention of marginal bone loss & soft tissue loss, postoperative pain and postoperative complications following bilateral premolar extractions for orthodontic purpose. In this prospective split-mouth study, outcomes of the 2 groups (n = 42 premolars) requiring extraction of premolars for orthodontic treatment purpose using Physics forceps and Conventional forceps were compared. Clinical outcomes in form of time taken, loss of buccal soft tissue and buccal cortical plate based on extraction defect classification system, postoperative pain and other complication associated with extraction were recorded and compared. Statistically significant reduction in the operating time was noted in physics forceps group. Marginal bone loss and soft tissue loss was also significantly lesser in physics forceps group when compared to conventional forceps group. However, there was no statistically significant difference in severity of postoperative pain between both groups. The results of the present study suggest that physics forceps was more efficient in reducing operating time and prevention of marginal bone loss & soft tissue loss when compared to conventional forceps in orthodontically indicated premolar extractions.

  11. MATHEMATICAL MODELING OF WELDING BLOOD VESSELS BY ELECTROSURGERY FORCEPS

    Directory of Open Access Journals (Sweden)

    Yarova S.O.

    2016-02-01

    Full Text Available Electrosurgical instruments for the coagulation of biological tissue is used in almost all surgical operations. SolidWorks modeling allows to obtain the distribution of the mechanical stresses, displacements and strains. The design of all types of forceps are made so that the electrodes were positioned at an angle. This improves the grip of the tissue, but leads to uneven compression. Bending the jaws of the forceps improves the uniformity of the stress distribution

  12. Obstetric Forceps: A Species on the Brink of Extinction.

    Science.gov (United States)

    Dildy, Gary A; Belfort, Michael A; Clark, Steven L

    2016-09-01

    Both resident training in the use of obstetric forceps and forceps deliveries are experiencing precipitous declines in the United States. Current minimum training requirements are insufficient to ensure competency in this skill. These trends bear striking similarities to observations regarding the decline and ultimate extinction of biologic species and portend the inevitable disappearance of this valuable skill from the obstetric armamentarium. Attempts by experienced teaching faculty to provide residents with experience in a few forceps deliveries are of little value and may do more harm than good. There would seem to be only two viable solutions to this dilemma: 1) abandon attempts to teach forceps and prepare residents for a real-world practice setting in which management of second-stage labor does not include the availability forceps delivery; or 2) prioritize the development of high-fidelity simulation models in which fetal head size and attitude and pelvic size and architecture can be continuously varied to allow residents to obtain sufficient experience to know both how and when to proceed with forceps delivery. We believe this latter approach is the sole alternative to inevitable extinction of this species.

  13. Vitrectorhexis versus forceps posterior capsulorhexis in pediatric cataract surgery

    Directory of Open Access Journals (Sweden)

    Lav Kochgaway

    2013-01-01

    Full Text Available This study was done to compare the results of posterior continuous curvilinear capsulorhexis created using forceps with those created using vitrector in eyes suffering from congenital cataract. Vitrectorhexis term was first used by Wilson et al in 1999. [1] Fifty eyes with congenital and developmental cataract were included in this study. The posterior capsulorhexis was created using utrata forceps in 17 eyes or through a vitrector in 33 eyes. Forceps capsulorhexis was performed before IOL implantation, while vitrectorhexis was performed after IOL implantation in the bag. The results of both the surgery were compared using the following criteria: incidence of extension of rhexis, ability to achieve posterior rhexis of appropriate size, ability to implant the IOL in the bag, the surgical time, and learning curve. Vitrectorhexis after IOL implantation was an easy to learn alternative to manual posterior continuous curvilinear capsulorhexis in pediatric cataract surgery. It was more predictable and reproducible, with a short learning curve and lesser surgical time.

  14. Comparison of sterilization of reusable endoscopic biopsy forceps by autoclaving and ethylene oxide gas.

    Science.gov (United States)

    Yoon, Jai Hoon; Yoon, Byung Chul; Lee, Hang Lak; Lee, Jun Kyu; Kim, Yong-Tae; Lee, Dong Ho; Choi, Il Ju; Lee, Don Haeng; Kim, Dong Hee

    2012-02-01

    Every country has standardized reprocessing guidelines for reducing the risk of microorganism transmission via reusable biopsy forceps. Sterilization is performed either by autoclaving or with the use of ethylene oxide (EO) gas. However, there are no clear standard global recommendations. The aim of this study was to determine whether EO gas or autoclaving is a safer and more effective method for the sterilization of reusable forceps. This was a prospective study conducted at multiple tertiary referral centers. Seventy reusable biopsy forceps that had been reused at least 20 times each were collected from six endoscopy centers. In all, 61 forceps from five centers were sterilized using EO gas, and the nine forceps from the remaining center were placed in an autoclave. We performed real-time polymerase chain reaction (RT-PCR) for Mycobacterium tuberculosis and hepatitis B virus and performed bacterial cultures on the reusable forceps, which were cut into 2- to 3-cm sections. The forceps were also scanned with an electron microscope (EM) to detect surface damage and contamination. Escherichia coli bacteria were cultured from 2 of the 61 (3.3%) reusable biopsy forceps sterilized with EO gas. On EM scanning, abundant debris and tissue materials remained on the cup surfaces of the reused biopsy forceps and on their inner wires. No microorganisms were found on the autoclaved forceps. Sterilization with EO gas may be inadequate because the complicated structure of the forceps may interfere with sterilization. Therefore, for optimum safety, reusable biopsy forceps should be sterilized by autoclaving.

  15. Percutaneous antegrade ureteric stent removal using a rigid alligator forceps.

    LENUS (Irish Health Repository)

    Given, M F

    2008-12-01

    To evaluate the safety and efficacy of percutaneous antegrade ureteric stent removal using a rigid alligator forceps. Twenty patients were included in our study. Indications for ureteric stent insertion included stone disease (n = 7), malignancy (n = 8) and transplant anastomotic strictures (n = 5). Stent retrieval was carried out for proximal stent placement\\/migration in seven patients and encrustation in the remaining 13. Twenty-two stents were successfully retrieved in 20 patients. There was one technical failure (5%). There were no major complications. We had four minor complications, which included nephrostomy site pain (n = 2), periprocedural sepsis (n = 1) and a small urinoma (n = 1). All patients settled with conservative management. Percutaneous radiologically guided antegrade ureteric stent removal with an alligator forceps is safe and effective, particularly when initial surgical removal has failed.

  16. Haemophilus influenzae biotype VII.

    OpenAIRE

    Gratten, M

    1983-01-01

    A hitherto unreported biotype of Haemophilus influenzae is described. The isolate is noncapsulate and fails to decarboxylate ornithine or hydrolyze urea but is a strong indole producer. Its frequency is low. It is suggested that this newly recognized biotype of H. influenzae be designated biotype VII.

  17. Cytological Sampling Versus Forceps Biopsy During Percutaneous Transhepatic Biliary Drainage and Analysis of Factors Predicting Success

    Energy Technology Data Exchange (ETDEWEB)

    Tapping, C. R.; Byass, O. R.; Cast, J. E. I., E-mail: james.cast@hey.nhs.uk [Hull Royal Infirmary, Department of Radiology (United Kingdom)

    2012-08-15

    Purpose: To assess the accuracy of cytological sampling and forceps biopsy in obstructing biliary lesions and to identify factors predictive of success. Methods: Consecutive patients (n = 119) with suspected malignant inoperable obstructive jaundice treated with percutaneous transhepatic biliary drainage during 7 years were included (60 male; mean age 72.5 years). All patients underwent forceps biopsy plus cytological sampling by washing the forceps device in cytological solution. Patient history, procedural and pathological records, and clinical follow-up were reviewed. Statistical analysis included chi-square test and multivariate regression analysis. Results: Histological diagnosis after forceps biopsy was more successful than cytology: Sensitivity was 78 versus 61%, and negative predictive value was 30 versus 19%. Cytology results were never positive when the forceps biopsy was negative. The cytological sample was negative and forceps sample positive in 2 cases of cholangiocarcinoma, 16 cases of pancreatic carcinoma, and 1 case of benign disease. Diagnostic accuracy was predicted by low bilirubin (p < 0.001), aspartate transaminase (p < 0.05), and white cell count (p {<=} 0.05). Conclusions: This technique is safe and effective and is recommended for histological diagnosis during PTBD in patients with inoperable malignant biliary strictures. Diagnostic yield is greater when bilirubin levels are low and there is no sepsis; histological diagnosis by way of forceps biopsy renders cytological sampling unnecessary.

  18. Percutaneous tracheostomy with the guide wire dilating forceps technique: presentation of 171 consecutive patients.

    NARCIS (Netherlands)

    Fikkers, B.G.; Heerbeek, N. van; Krabbe, P.F.M.; Marres, H.A.M.; Hoogen, F.J.A. van den

    2002-01-01

    BACKGROUND: Evaluation of percutaneous tracheostomy (PT) with the guide wire dilating forceps (GWDF) technique. METHODS: Prospective study of perioperative complications, retrospective analysis of early and late complications in an ICU in a teaching university hospital. RESULTS: The success rate of

  19. Percutaneous tracheostomy with the guide wire dilating forceps technique : presentation of 171 consecutive patients

    NARCIS (Netherlands)

    Fikkers, Bernard G; van Heerbeek, Niels; Krabbe, Paul F M; Marres, Henri A M; van den Hoogen, Frank J A

    BACKGROUND: Evaluation of percutaneous tracheostomy (PT) with the guide wire dilating forceps (GWDF) technique. METHODS: Prospective study of perioperative complications, retrospective analysis of early and late complications in an ICU in a teaching university hospital. RESULTS: The success rate of

  20. A new specifically designed forceps for chest drain insertion.

    LENUS (Irish Health Repository)

    Andrews, Emmet

    2012-02-03

    Insertion of a chest drain can be associated with serious complications. It is recommended that the drain is inserted with blunt dissection through the chest wall but there is no specific instrument to aid this task. We describe a new reusable forceps that has been designed specifically to facilitate the insertion of chest drains.A feasibility study of its use in patients who required a chest drain as part of elective cardiothoracic operations was undertaken. The primary end-point was successful and accurate placement of the drain. The operators also completed a questionnaire rating defined aspects of the procedure. The new instrument was used to insert the chest drain in 30 patients (19 male, 11 female; median age 61.5 years (range 16-81 years)). The drain was inserted successfully without the trocar in all cases and there were no complications. Use of the instrument rated as significantly easier relative to experience of previous techniques in all specified aspects. The new device can be used to insert intercostal chest drains safely and efficiently without using the trocar or any other instrument.

  1. Endoscopic submucosal dissection using a novel grasping type scissors forceps.

    Science.gov (United States)

    Akahoshi, K; Akahane, H; Murata, A; Akiba, H; Oya, M

    2007-12-01

    Endoscopic submucosal dissection (ESD) with a knife is a technically demanding procedure that is associated with a high complication rate. The shortcoming of this method is the difficulty in fixing the knife to the target lesion. This difficulty can lead to unexpected incision, resulting in major complications such as perforation and bleeding. To reduce the risk of complications related to ESD, we developed a new grasping type scissors forceps (GSF), which can grasp and incise the targeted tissue using an electrosurgical current. The ESD procedure using the GSF was carried out in an animal model (resected porcine stomachs in vitro). After marking the lesion and injecting a solution into the submucosa, the lesion was separated from the surrounding normal mucosa following complete incision around the lesion using the GSF. A piece of submucosal tissue was grasped and cut with the GSF using an electrosurgical current to achieve submucosal exfoliation. ESD using the GSF was carried out safely and easily without unintentional incision. ESD using GSF appears to be an easy, safe, and technically efficient method for resecting gastrointestinal neoplasms.

  2. Usefulness of needle holder with a function of fine forceps for bypass surgery in both hands.

    Science.gov (United States)

    Horiuchi, Tetsuyoshi; Seguchi, Tatsuya; Ito, Kiyoshi; Hongo, Kazuhiro

    2015-01-01

    In bypass surgery, a single-handed needle holder is usually used with other handed fine forceps. Recently, a needle holder with the function of fine forceps has been developed. In this technical note, usefulness of newly developed needle holders in both hands is presented in bypass surgery. With this method, surgeons can make stitches and ties by both hands without exchanging instruments. This method is effective and may result in faster anastomotic procedure comparing with the traditional one.

  3. Percutaneous transluminal biopsy using 7F forceps for diagnosing malignant biliary obstruction

    Energy Technology Data Exchange (ETDEWEB)

    Bahn, Young Eun; Kim, Young Hwan; An, Eun Jung; Kim, See Hyung [Keimyung Univ. College of Medicine, Daegu (Korea, Republic of)

    2012-07-15

    To evaluate the usefulness of the percutaneous transluminal biopsy using 7-F forceps for diagnosing malignant biliary obstruction. One hundred and seven consecutive patients with obstructive jaundice underwent transluminal forceps biopsy. The lesions involved the common bile duct (n = 33), common hepatic duct (n = 13), hilum (n = 17), right or left intrahepatic bile duct (n = 32), multiple sites (extra and intrahepatic ducts, n = 7), or anastomotic sites (n = 5). In each patient, an average of three specimens was taken with 7F biopsy forceps through a transhepatic biliary drainage tract. The final diagnosis was confirmed with pathologic findings, or a clinical and radiologic follow up. The final diagnoses showed malignancies in 75 patients and benign biliary obstructions in 32 patients. Pathologic classifications of malignancies established by forceps biopsy included 67 adenocarcinomas, 1 adenosquamous cell carcinoma, and 1 hepatocelluar carcinoma. There were 6 false-negative diagnoses. The diagnostic performance of transluminal forceps biopsy in malignant biliary obstruction had a sensitivity of 92%, specificity of 100%, positive predictive value of 100%, a negative predictive value of 84.2%, and an accuracy of 94.2%. Percutaneous transluminal forceps biopsy is a safe procedure that is easy to perform through a transhepatic biliary drainage tract. It is a highly accurate technique for diagnosing malignant biliary obstructions.

  4. Rectal biopsies obtained with jumbo biopsy forceps in the evaluation of Hirschsprung disease.

    Science.gov (United States)

    Hirsch, Barry Z; Angelides, Anastasios G; Goode, Susan P; Garb, Jane L

    2011-04-01

    Refractory constipation is an extremely common problem in infants and children. The diagnostic suspicion of Hirschsprung disease often arises in this clinical setting. Diagnosing Hirschsprung disease can be difficult; however, excluding the diagnosis is much easier, only requiring the demonstration of ganglion cells in the distal rectum. The most common method for obtaining tissue from the rectum involves a blind suction biopsy. This technique has been complicated by serious adverse events, equipment malfunction, and inadequate specimens. Our goal was to evaluate the adequacy of specimens obtained with a flexible endoscope and jumbo biopsy forceps to rule out Hirschsprung disease in the child outside the newborn period. We retrospectively reviewed 668 rectal biopsies taken during 167 endoscopies on 156 patients being evaluated for Hirschsprung disease from 2001 to 2008 at the Baystate Medical Center Children's Hospital. Four biopsies were taken from each patient approximately 2.5 cm from the anal verge. Biopsies were obtained using a flexible endoscope and jumbo biopsy forceps. During the first 6 years the Olympus FB-50U-1 large cup fenestrated biopsy forceps was used. During the last 2 years the Boston Scientific Radial Jaw 4 Jumbo biopsy forceps was used instead. The Boston Scientific Radial Jaw 4 Jumbo biopsy forceps yielded adequate specimens 93% of the time, which surpassed most published results of other techniques. There were no complications reported. Obtaining rectal biopsies with a flexible endoscope and jumbo biopsy forceps is a safe and effective means to rule out the diagnosis of Hirschsprung disease in children.

  5. A grasping forceps with a triaxial MEMS tactile sensor for quantification of stresses on organs.

    Science.gov (United States)

    Kuwana, K; Nakai, A; Masamune, K; Dohi, T

    2013-01-01

    This paper reports on a grasping forceps with a triaxial Micro Electro Mechanical Systems (MEMS) tactile sensor on a tip. The laparoscopic surgery is minimally invasive because the incisions are smaller than the open surgery. This results in fast recovery. However, it is a problem in the laparoscopic surgery to damage an organ by localized stress generated by grasping with a thin forceps. To avoid excessive stress applying to the organ, real time evaluation of the stress is important. However, there is no acceptable tool to measure the stress. We propose a grasping forceps with a triaxial MEMS tactile sensor on a tip for a measurement tool. We attached a triaxial MEMS tactile sensor which we have developed on a tip of a grasping forceps. The MEMS sensor can measure not only the pressure but also two directional shear stresses applied to the sensor surface. The sensor size is 7 mm × 7 mm × 2 mm. It is enough small to attach the sensor to the tip of a forceps 12 mm in diameter. In this paper, the characteristics of the forceps with the MEMS sensor during grasping, pushing and pulling actions were evaluated. In these experiments, output of each sensor for pressure and shear stress was proportional to the applied stresses, respectively. Moreover, as an in vivo experiment, we measured the shear stress applied to a pig liver block when it is lifted after being grasped with the forceps. We obtained that the shear stress applied to the liver block increased with the increase of the weight of the liver block.

  6. A treatment method for chronic suppurative lacrimal canaliculitis using chalazion forceps

    Directory of Open Access Journals (Sweden)

    Xiuming Jin

    2016-01-01

    Full Text Available Purpose: The purpose of this study is to evaluate the effectiveness of chronic suppurative lacrimal canaliculitis treatment using chalazion forceps. Patients and Methods: A prospective study was performed on consecutive patients who accepted the aid of chalazion forceps to treat chronic suppurative lacrimal canaliculitis. Two different treatment methods using chalazion forceps were performed according to the degree of lacrimal canaliculitis. Postoperatively, the patients received 0.5% levofloxacin eye drops four times per day and 0.5 g oral levofloxacin tablets once per day for 4 days. The follow-up period was more than 3 months. Lacrimal irrigation, the condition of the lacrimal punctum, and patients′ symptoms were carefully evaluated. Results: In total, 32 patients met the criteria for chronic suppurative lacrimal canaliculitis. Included were 6 males and 26 females. Their average age was 51.7 ± 14.9 years (range; 19-80 years, and all had unilateral canaliculitis. The mean duration of the symptoms was 18.9 ± 9.8 months (range; 3-48 months. The mean follow-up time was 14.7 ± 7.8 months. The signs and symptoms resolved completely in all patients within 15 days, and no recurrence was observed. No patients reported epiphora after the treatment. Conclusions: The use of chalazion forceps is effective in treating chronic suppurative lacrimal canaliculitis. The forceps may offer an alternative treatment technology in the management of suppurative lacrimal canaliculitis.

  7. A treatment method for chronic suppurative lacrimal canaliculitis using chalazion forceps.

    Science.gov (United States)

    Jin, Xiuming; Fan, Fangli; Zhang, Fan; Zhao, Yingying; Hu, Renjian

    2016-08-01

    The purpose of this study is to evaluate the effectiveness of chronic suppurative lacrimal canaliculitis treatment using chalazion forceps. A prospective study was performed on consecutive patients who accepted the aid of chalazion forceps to treat chronic suppurative lacrimal canaliculitis. Two different treatment methods using chalazion forceps were performed according to the degree of lacrimal canaliculitis. Postoperatively, the patients received 0.5% levofloxacin eye drops four times per day and 0.5 g oral levofloxacin tablets once per day for 4 days. The follow-up period was more than 3 months. Lacrimal irrigation, the condition of the lacrimal punctum, and patients' symptoms were carefully evaluated. In total, 32 patients met the criteria for chronic suppurative lacrimal canaliculitis. Included were 6 males and 26 females. Their average age was 51.7 ± 14.9 years (range; 19-80 years), and all had unilateral canaliculitis. The mean duration of the symptoms was 18.9 ± 9.8 months (range; 3-48 months). The mean follow-up time was 14.7 ± 7.8 months. The signs and symptoms resolved completely in all patients within 15 days, and no recurrence was observed. No patients reported epiphora after the treatment. The use of chalazion forceps is effective in treating chronic suppurative lacrimal canaliculitis. The forceps may offer an alternative treatment technology in the management of suppurative lacrimal canaliculitis.

  8. Evaluation of microsurgical tasks with OCT-guided and/or robot-assisted ophthalmic forceps

    Science.gov (United States)

    Yu, Haoran; Shen, Jin-Hui; Shah, Rohan J.; Simaan, Nabil; Joos, Karen M.

    2015-01-01

    Real-time intraocular optical coherence tomography (OCT) visualization of tissues with surgical feedback can enhance retinal surgery. An intraocular 23-gauge B-mode forward-imaging co-planar OCT-forceps, coupling connectors and algorithms were developed to form a unique ophthalmic surgical robotic system. Approach to the surface of a phantom or goat retina by a manual or robotic-controlled forceps, with and without real-time OCT guidance, was performed. Efficiency of lifting phantom membranes was examined. Placing the co-planar OCT imaging probe internal to the surgical tool reduced instrument shadowing and permitted constant tracking. Robotic assistance together with real-time OCT feedback improved depth perception accuracy. The first-generation integrated OCT-forceps was capable of peeling membrane phantoms despite smooth tips. PMID:25780736

  9. The art of performing a safe forceps delivery: a skill to revitalise.

    Science.gov (United States)

    Rather, Henna; Muglu, Javaid; Veluthar, Luxmi; Sivanesan, K

    2016-04-01

    The number of forceps deliveries is globally falling possibly due to Obstetricians gaining more experience and competence in the use of Ventouse deliveries. The declining use of traction forceps can increase the rate of second stage caesarean sections, which may have a long-term impact on the overall rate of vaginal births, despite the efforts of improving uptake of vaginal births after caesarean sections. The failures in forceps deliveries are commonly related to inaccurate assessment of the foetal position and station, which can be addressed by gaining sound clinical experience and applying intra-partum scanning to determine the fetal head position in the second stage, and should be part of the core curriculum in obstetric training. The alternate techniques of rotation, like digital and manual rotation, should be taught and encouraged in cases where rotation is required, which will significantly increase the success rate of instrumental deliveries. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  10. Kielland's forceps: does it increase the risk of anal sphincter injuries? An observational study.

    Science.gov (United States)

    Gauthaman, Nivedita; Henry, Denise; Ster, Irina Chis; Khunda, Azar; Doumouchtsis, Stergios K

    2015-10-01

    Rotational instrumental deliveries are thought to carry additional risks compared with non-rotational instrumental deliveries, including trauma to maternal tissues, and require specific expertise and training. We conducted a retrospective study to investigate the association between the type of forceps delivery and maternal perineal trauma, and in particular to investigate if Kielland's rotational forceps delivery increases obstetric anal sphincter injuries (OASIS). This is a retrospective observational study of 1,515 women who attended a tertiary maternity unit over a period of 5 years and had operative vaginal deliveries primarily or completed by forceps. Data were obtained through the hospital's maternity reporting system. The severity of maternal perineal trauma, particularly third and fourth-degree tears in relation to the type of forceps delivery was explored. Multinomial logistic regression models were used to estimate the crude and the adjusted relative risks (RR) of sustaining third-degree tears compared with other types of vaginal tears. Univariate analyses explored the crude associations between relative risks and age, ethnicity, birth weight, type of instrumental delivery and operator's experience. A multivariate multinomial logistic regression model estimated the adjusted relative risks and included all the previous variables as independent covariates. Of the 1,492 women included in the study, 150 women (77 %) had sustained category 1 tears, 63 women (4 %) had sustained category 2 tears and 279 women (19 %) had sustained third-degree tears. There was no statistically significant association between the severity of maternal perineal trauma and the type of forceps delivery (failed ventouse vs Kielland's forceps RR 1.52, p = 0.159 CI 0.84-2.72, Wrigleys vs Kielland's RR 0.59, p = 0.249, CI 0.24-1.43; Andersons vs Kielland's RR 1.16, p = 0.603, CI 0.65-2.05) after adjusting for age, birth weight, BMI, ethnicity and operator experience (full

  11. Factor VII-activating protease

    DEFF Research Database (Denmark)

    Ramanathan, Ramshanker; Gram, Jørgen B; Sand, Niels Peter R

    2017-01-01

    : Factor VII-activating protease (FSAP) may regulate development of cardiovascular disease (CVD). We evaluated sex differences in FSAP measures and examined the association between FSAP and coronary artery calcification (CAC) in a middle-aged population. Participants were randomly selected citizens...

  12. Usefulness and safety of biliary percutaneous transluminal forceps biopsy (PTFB): our experience.

    Science.gov (United States)

    Ierardi, Anna Maria; Mangini, Monica; Fontana, Federico; Floridi, Chiara; De Marchi, Giuseppe; Petrillo, Mario; Capasso, Raffaella; Chini, Claudio; Cocozza, Eugenio; Cuffari, Salvatore; Segato, Sergio; Rotondo, Antonio; Carrafiello, Gianpaolo

    2014-03-01

    To evaluate the usefulness and safety of percutaneous transluminal forceps biopsy in patients suspected of having a malignant biliary obstruction. Forty consecutive patients (21 men and 19 women; mean age, 71.9 years) underwent forceps biopsy through percutaneous transhepatic biliary access performed to drain bile. Lesions involved the common bile duct (n 8), common hepatic duct (n 18), hilum (n 6), ampullary segment of the common bile duct (n 8) and were biopsied with 7-F biopsy forceps. Final diagnosis was confirmed with pathologic findings at surgery, or clinical and radiologic follow-up. Twenty-one of 40 biopsies resulted in correct diagnosis of malignancy. Thirteen biopsy diagnosis were proved to be true-negative. There were six false-negative and no false-positive diagnoses. Sensitivity, specificity and accuracy in aspecific biliary obstructions were 85%, 100% and 88,7% respectively. Sensitivity of biopsy in malignancies was higher than in benign obstructions (100% vs 68,4%, CI = 95%). Sensitivity was lower in the hilum tract and in the common bile duct than in other sites (CI = 95%). No major complications related to biopsy procedures occurred. Percutaneous transluminal forceps biopsy is a safe procedure, easy to perform through a transhepatic biliary drainage tract, providing high accuracy in the diagnosis of malignant biliary obstructions.

  13. Cryobiopsy: should this be used in place of endobronchial forceps biopsies?

    Science.gov (United States)

    Rubio, Edmundo R; le, Susanti R; Whatley, Ralph E; Boyd, Michael B

    2013-01-01

    Forceps biopsies of airway lesions have variable yields. The yield increases when combining techniques in order to collect more material. With the use of cryotherapy probes (cryobiopsy) larger specimens can be obtained, resulting in an increase in the diagnostic yield. However, the utility and safety of cryobiopsy with all types of lesions, including flat mucosal lesions, is not established. Demonstrate the utility/safety of cryobiopsy versus forceps biopsy to sample exophytic and flat airway lesions. Teaching hospital-based retrospective analysis. Retrospective analysis of patients undergoing cryobiopsies (singly or combined with forceps biopsies) from August 2008 through August 2010. Statistical Analysis. Wilcoxon signed-rank test. The comparative analysis of 22 patients with cryobiopsy and forceps biopsy of the same lesion showed the mean volumes of material obtained with cryobiopsy were significantly larger (0.696 cm(3) versus 0.0373 cm(3), P = 0.0014). Of 31 cryobiopsies performed, one had minor bleeding. Cryopbiopsy allowed sampling of exophytic and flat lesions that were located centrally or distally. Cryobiopsies were shown to be safe, free of artifact, and provided a diagnostic yield of 96.77%. Cryobiopsy allows safe sampling of exophytic and flat airway lesions, with larger specimens, excellent tissue preservation and high diagnostic accuracy.

  14. Cryobiopsy: Should This Be Used in Place of Endobronchial Forceps Biopsies?

    Directory of Open Access Journals (Sweden)

    Edmundo R. Rubio

    2013-01-01

    Full Text Available Forceps biopsies of airway lesions have variable yields. The yield increases when combining techniques in order to collect more material. With the use of cryotherapy probes (cryobiopsy larger specimens can be obtained, resulting in an increase in the diagnostic yield. However, the utility and safety of cryobiopsy with all types of lesions, including flat mucosal lesions, is not established. Aims. Demonstrate the utility/safety of cryobiopsy versus forceps biopsy to sample exophytic and flat airway lesions. Settings and Design. Teaching hospital-based retrospective analysis. Methods. Retrospective analysis of patients undergoing cryobiopsies (singly or combined with forceps biopsies from August 2008 through August 2010. Statistical Analysis. Wilcoxon signed-rank test. Results. The comparative analysis of 22 patients with cryobiopsy and forceps biopsy of the same lesion showed the mean volumes of material obtained with cryobiopsy were significantly larger (0.696 cm3 versus 0.0373 cm3, P=0.0014. Of 31 cryobiopsies performed, one had minor bleeding. Cryopbiopsy allowed sampling of exophytic and flat lesions that were located centrally or distally. Cryobiopsies were shown to be safe, free of artifact, and provided a diagnostic yield of 96.77%. Conclusions. Cryobiopsy allows safe sampling of exophytic and flat airway lesions, with larger specimens, excellent tissue preservation and high diagnostic accuracy.

  15. Spring in the Arab Spring

    NARCIS (Netherlands)

    Borg, G.J.A.

    2011-01-01

    Column Gert Borg | Spring in the Arab Spring door dr. Gert Borg, onderzoeker bij Islam en Arabisch aan de Radboud Universiteit Nijmegen en voormalig directeur van het Nederlands-Vlaams Instituut Caïro Spring If, in Google, you type "Arab Spring" and hit the button, you get more than

  16. Positivity VII (Zaanen Centennial Conference)

    CERN Document Server

    Pagter, Ben; Gaans, Onno; Veraar, Mark

    2016-01-01

    This book presents the proceedings of Positivity VII, held from 22-26 July 2013, in Leiden, the Netherlands. Positivity is the mathematical field concerned with ordered structures and their applications in the broadest sense of the word. A biyearly series of conferences is devoted to presenting the latest developments in this lively and growing discipline. The lectures at the conference covered a broad spectrum of topics, ranging from order-theoretic approaches to stochastic processes, positive solutions of evolution equations and positive operators on vector lattices, to order structures in the context of algebras of operators on Hilbert spaces. The contributions in the book reflect this variety and appeal to university researchers in functional analysis, operator theory, measure and integration theory and operator algebras. Positivity VII was also the Zaanen Centennial Conference to mark the 100th birth year of Adriaan Cornelis Zaanen, who held the chair of Analysis in Leiden for more than 25 years and was ...

  17. Measurement of the Physical Properties during Laparoscopic Surgery Performed on Pigs by Using Forceps with Pressure Sensors

    Directory of Open Access Journals (Sweden)

    Hiroyuki Yamanaka

    2015-01-01

    Full Text Available Objectives. Here we developed a unique training system, a patient specific virtual reality simulator, for laparoscopic renal surgery. To develop the simulator, it was important to first identify the physical properties of the organ. Methods. We recorded the force measured during laparoscopic surgery performed on pigs by using forceps with pressure sensors. Several sensors, including strain gauges, accelerometers, and a potentiometer, are attached to the forceps. Results. Throughout the experiment, we measured the reaction force in response to the forceps movement in real time. Conclusions. The experiment showed the possibility of digitizing these physical properties in humans as well.

  18. Highlights of Spanish Astrophysics VII

    Science.gov (United States)

    Guirado, J. C.; Lara, L. M.; Quilis, V.; Gorgas, J.

    2013-05-01

    "Highlights of Astronomy and Astrophysics VII" contains the Proceedings of the biannual meeting of the Spanish Astronomical Society held in Valencia from July 9 to 13, 2012. Over 300 astronomer, both national and international researchers, attended to the conference covering a wide variety of astrophysical topics: Galaxies and Cosmology, The Milky Way and Its Components, Planetary Sciences, Solar Physics, Instrumentation and Computation, and Teaching and Outreach of Astronomy.

  19. Congenital deficiency of factor VII.

    Science.gov (United States)

    Sikka, M; Gomber, S; Madan, N; Rusia, U; Sharma, S

    1996-01-01

    A case of congenital factor VII deficiency in a five-year-old child is reported. The patient, born of a non-consanguineous marriage, presented with repeated bouts of epistaxis since childhood. The prothrombin time (PT) was markedly prolonged with a normal bleeding time (BT), partial thromboplastin time with Kaolin (PTTK) and platelet count. The patient has been on follow up for the last four years and is doing apparently well.

  20. Framework Spring

    OpenAIRE

    Bobkov, Pavel

    2010-01-01

    The aim of the thesis is to introduce reader to the Spring framework and describe it as a convenient tool for rapid application development and launching projects. It is necessary to grab the Spring issue in a broader context. That's why thesis is trying to note all the relevant technologies that are closely related to Spring, or which is Spring based on. The first step to understanding Spring is a basic knowledge of Java EE. Thesis presents the architecture of Java EE while arguing its flaws...

  1. Prospective Randomized Clinical Trial on Suction Elastic Band Ligator Versus Forceps Ligator in the Treatment of Haemorrhoids

    Directory of Open Access Journals (Sweden)

    A.R. Mohd Ramzisham

    2005-10-01

    Conclusion: Suction band ligation is superior to forceps ligation for the treatment of second- and third-degree haemorrhoids in terms of pain tolerance, amount of analgesia consumed and intra-procedure bleeding.

  2. Obliteration of symptomatic Schatzki rings with jumbo biopsy forceps (with video).

    Science.gov (United States)

    Gonzalez, A; Sullivan, M F; Bonder, A; Allison, H V; Bonis, P A; Guelrud, M

    2014-01-01

    A Schatzki ring is a submucosal, fibrotic thickening located at the gastroesophageal junction. Endoscopic treatment traditionally involves disruption of the ring. Many approaches have been described including bougies, balloons, biopsies, and diathermic monopolar incision. While all of these approaches are effective in the short-term, recurrence is common. The objective of our study was to evaluate the feasibility of complete excision of the ring using jumbo cold biopsy forceps. Our main outcome measurements were the feasibility, safety, and efficacy of complete obliteration of Schatzki rings using jumbo cold biopsy forceps. We designed an observational study using a standard protocol for patient management and data collection using a university hospital as our setting. We followed 10 patients with dysphagia due to a Schatzki's ring, six of whom had previously undergone bougienage or balloon dilation. Five patients were on maintenance therapy with a proton pump inhibitor and one with an H2 blocker. Complete endoscopic obliteration of the Schatzki rings with a cold jumbo biopsy forceps was achieved in all 10 patients requiring a mean of 9.8 biopsies (range 8-12). Omeprazole (20 mg twice daily) was prescribed after the procedure. All 10 patients demonstrated improvement in dysphagia after treatment, which persisted during a mean follow-up time of 379 days (range 63-496 days). There were no serious complications. The limitations of our study include lack of a control group, a small sample size, and being a single-institution study. We concluded that complete Schatzki ring obliteration with jumbo cold biopsy forceps is a safe, feasible, and effective endoscopic treatment. © 2014 International Society for Diseases of the Esophagus.

  3. Perinatal and Maternal Outcomes After Training Residents in Forceps Before Vacuum Instrumental Birth.

    Science.gov (United States)

    Skinner, Sasha; Davies-Tuck, Miranda; Wallace, Euan; Hodges, Ryan

    2017-07-01

    To compare the rates of attempted and successful instrumental births, intrapartum cesarean delivery, and subsequent perinatal and maternal morbidity before and after implementing a training intervention to arrest the decline in forceps competency among resident obstetricians. This retrospective cohort study examined all attempted instrumental births at Monash Health from 2005 to 2014. We performed an interrupted time-series analysis to compare outcomes of attempted instrumental births in 2005-2009 with those in 2010-2014. There were 72,490 births from 2005 to 2014 at Monash Health, of which 8,789 (12%) were attempted instrumental vaginal births. After the intervention, rates of forceps births increased [autoregressive integrated moving average coefficient (β) 1.5, 95% confidence interval (CI) 1.03-1.96; Pinstrumental births (β -0.39, 95% CI -3.03 to 2.43; P=.83), intrapartum cesarean delivery (β -0.29, 95% CI -0.55 to 0.14; P=.24), third- and fourth-degree tears (β -1.04, 95% CI -3.1 to 1.00; P=.32), or composite neonatal morbidity (β -0.18, 95% CI -0.38 to 0.02, P=.08). Unsuccessful instrumental births were more likely to be in nulliparous women (P<.001), less likely to have a senior obstetrician present (P<.001), be at later gestation (P<.001), and involved larger birth weight neonates (P<.001). A policy of ensuring obstetric forceps competency before beginning vacuum training results in more forceps births, fewer postpartum hemorrhages, and no increase in third- and fourth-degree perineal injuries or episiotomies.

  4. Comparison of different biopsy forceps models for tissue sampling in eosinophilic esophagitis.

    Science.gov (United States)

    Bussmann, Christian; Schoepfer, Alain M; Safroneeva, Ekaterina; Haas, Nadine; Godat, Sébastien; Sempoux, Christine; Simon, Hans-Uwe; Straumann, Alex

    2016-12-01

    Background and aims: Eosinophilic esophagitis (EoE) is a mixed inflammatory and fibrostenotic disease. Unlike superficial inflammatory changes, subepithelial fibrosis is not routinely sampled in esophageal biopsies. This study aimed to evaluate the efficacy and safety of deep esophageal sampling with four different types of biopsy forceps. Patients and methods: In this cross-sectional study, esophageal biopsies were taken in 30 adult patients by one expert endoscopist. Biopsies sampled from distal esophagus using a static jaw forceps (Olympus, FB-11K-1) were compared with proximal biopsies sampled with static jaw (Olympus, FB-45Q-1), alligator jaw (Olympus, FB-210K), and large-capacity forceps (Boston Scientific, Radial Jaw 4). One pathologist calculated the surface area of epithelial and subepithelial layers in hematoxylin and eosin (H&E)-stained biopsies. Results: Subepithelial tissue was acquired in 97 % (static jaw FB-11K-1), 93 % (static jaw FB-45Q-1), 80 % (alligator jaw), and 55 % (large-capacity) of samples. Median (interquartile [IQR]) ratios of surface area of epithelial to subepithelial tissue were: static jaw FB-45Q-1, 1.07 (0.65 - 4.465); static jaw FB-11K-1, 1.184 (0.608 - 2.545); alligator jaw, 2.353 (1.312 - 4.465); and large-capacity, 2.71 (1.611 - 4.858). The static jaw models obtained a larger surface area of subepithelial tissue compared with the alligator jaw ( P   90 % of biopsies and appear to be superior to alligator or large-capacity forceps in sampling larger amounts of subepithelial tissue. © Georg Thieme Verlag KG Stuttgart · New York.

  5. Exploring the newborn head diameters in relation to current obstetric forceps' dimensions: A systematic review.

    Science.gov (United States)

    T Ismail, Abdul-Qader; Yates, Derick; Chester, Jonathan; Ismail, Khaled M K

    2018-01-01

    The aim of this study was to systematically search the literature for studies that reported term neonate head size and shape, in an attempt to determine the most appropriate dimensions for the obstetric forceps. We searched the Ovid Medline, Ovid Embase and Ebscohost CINAHL databases from inception to February 2016. We predefined inclusion criteria to identify studies in which head width and length of asymptomatic, term neonates were measured soon after birth using direct, non-photographic methods A bespoke quality assessment score was used to evaluate the identified studies. Seven studies were identified which measured head width (biparietal diameter) in 551 neonates; giving a mean value of 94.0mm (range 90.7mm-95.5mm). We identified one study which measured head length (mentovertical diameter) in 38 neonates; which gave a mean value of 134.5mm (range 129mm-139mm). This data, in conjunction with measurements of Neville Barnes' and Wrigley's forceps from our previous study, indicates current obstetric forceps' blades are too long, and close together. Potentially, this could be contributing to neonatal and maternal injuries associated with operational vaginal deliveries. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Intraocular Microsurgical Forceps (20, 23, and 25 gauge Membrane Peeling Forces Assessment

    Directory of Open Access Journals (Sweden)

    Raul Velez-Montoya

    2013-01-01

    Full Text Available Background. To assess the peeling forces exerted by different calibers of microsurgical forceps on an experimental model of epiretinal membrane. Methods. A model of epiretinal membrane was constructed using thin cellulose paper and heptanes-isopropyl alcohol 1% mixture. The model was mounted on a force censoring device. Subsequently, flaps were created with three different microsurgical forceps of different calibers. We recorded the number of attempts, the duration of the event, and the pushing and the pulling forces during the peeling. The results were compared by a one-way ANOVA and a Fisher unprotected least significant difference test with an alpha value of 0.05 for statistically significance. Results. There was a statistical significant difference on the pulling and pushing forces between the 25 gauge (13.79 mN; −13.27 mN and the 23 (6.63 mN; −5.76 mN and 20 (5.02 mN; −5.30 mN gauge, being greater in the first (. There were no differences in the duration of all events, meaning that all the forces were measured within the same period of time. Conclusions. The 25 gauge microsurgical forceps exerted the greatest mechanical stress over our simulated epiretinal membrane model and required more attempts to create a surgical suitable flap. The clinical implication of this finding is still to be determined.

  7. Forceps, Actual Use, and Potential Cesarean Section Prevention: Study in a Selected Mexican Population

    Directory of Open Access Journals (Sweden)

    Rodrigo Ayala-Yáñez

    2015-01-01

    Full Text Available Objective. Assessment of the frequency of complications observed with various forceps and operative vaginal delivery (OVD techniques performed at the ABC Medical Center (Mexico City to evaluate their safety, bearing in mind the importance of decreasing our country’s high cesarean section incidence. Methods. We reviewed 5,375 deliveries performed between the years 2007 and 2012, only 146 were delivered by OVD.  Results. Only 1.0% of the cases had a serious, life-threatening situation (uterine rupture. The Simpson forceps was the most favored instrument (46% due to its simplicity of use, effectiveness, and familiarity. Prophylactic use was the most common indication (30.8% and significant complications observed were vaginal lacerations (p=0.016, relative risk (RR of 3.4 (95% confidence interval [CI]: 1.15–10.04, and fourth degree perineal tear (p=0.016, RR of 3.4 (95% CI: 1.15–10.04. Conclusions. Forceps use and other OVD techniques are a safe alternative to be considered, diminishing C-section incidence and its complications.

  8. Forceps, Actual Use, and Potential Cesarean Section Prevention: Study in a Selected Mexican Population

    Science.gov (United States)

    Ayala-Yáñez, Rodrigo; Bayona-Soriano, Paulette; Hernández-Jimenez, Arturo; Contreras-Rendón, Alejandra; Chabat-Manzanera, Paulina; Nevarez-Bernal, Roberto

    2015-01-01

    Objective. Assessment of the frequency of complications observed with various forceps and operative vaginal delivery (OVD) techniques performed at the ABC Medical Center (Mexico City) to evaluate their safety, bearing in mind the importance of decreasing our country's high cesarean section incidence. Methods. We reviewed 5,375 deliveries performed between the years 2007 and 2012, only 146 were delivered by OVD.  Results. Only 1.0% of the cases had a serious, life-threatening situation (uterine rupture). The Simpson forceps was the most favored instrument (46%) due to its simplicity of use, effectiveness, and familiarity. Prophylactic use was the most common indication (30.8%) and significant complications observed were vaginal lacerations (p = 0.016), relative risk (RR) of 3.4 (95% confidence interval [CI]: 1.15–10.04), and fourth degree perineal tear (p = 0.016), RR of 3.4 (95% CI: 1.15–10.04). Conclusions. Forceps use and other OVD techniques are a safe alternative to be considered, diminishing C-section incidence and its complications. PMID:26380111

  9. Beginning Spring

    CERN Document Server

    Caliskan, Mert

    2015-01-01

    Get up to speed quickly with this comprehensive guide toSpring Beginning Spring is the complete beginner's guide toJava's most popular framework. Written with an eye towardreal-world enterprises, the book covers all aspects of applicationdevelopment within the Spring Framework. Extensive samples withineach chapter allow developers to get up to speed quickly byproviding concrete references for experimentation, building askillset that drives successful application development byexploiting the full capabilities of Java's latest advances. Spring provides the exact toolset required to build anent

  10. Just Spring

    CERN Document Server

    Konda, Madhusudhan

    2011-01-01

    Get a concise introduction to Spring, the increasingly popular open source framework for building lightweight enterprise applications on the Java platform. This example-driven book for Java developers delves into the framework's basic features, as well as advanced concepts such as containers. You'll learn how Spring makes Java Messaging Service easier to work with, and how its support for Hibernate helps you work with data persistence and retrieval. Throughout Just Spring, you'll get your hands deep into sample code, beginning with a problem that illustrates dependency injection, Spring's co

  11. Diagnostic yield and safety of jumbo biopsy forceps in patients with subepithelial lesions of the upper and lower GI tract.

    Science.gov (United States)

    Buscaglia, Jonathan M; Nagula, Satish; Jayaraman, Vijay; Robbins, David H; Vadada, Deepak; Gross, Seth A; DiMaio, Christopher J; Pais, Shireen; Patel, Kal; Sejpal, Divyesh V; Kim, Michelle K

    2012-06-01

    EUS-FNA often fails to make a definitive diagnosis in the evaluation of subepithelial lesions. The addition of jumbo biopsy forceps has the potential to improve diagnostic yield, but published series are limited. To assess the likelihood of definitive diagnosis for subepithelial lesions by using jumbo biopsy forceps during EUS examination. Pooled retrospective analysis. 6 tertiary referral centers. All patients having undergone EUS examination for a subepithelial lesion in which jumbo biopsy forceps were used for tissue acquisition. Diagnostic yield of jumbo biopsy forceps use, complication rates, and comparison of diagnostic yield with that of EUS-FNA. A total of 129 patients underwent EUS with jumbo biopsy forceps; 31 patients (24%) had simultaneous EUS-FNA. The lesion locations were stomach (n = 98), esophagus (n = 14), duodenum (n = 11), colon (n = 5), and jejunum (n = 1). The average lesion size was 14.9 mm ± 9.3 mm. Overall, definitive diagnosis was obtained in 87 of 129 patients (67.4%) by using either method. A definitive diagnosis was provided by jumbo biopsy forceps use in 76 of 129 patients (58.9%) and by FNA in 14 of 31 patients (45.1%) (P = .175). The results in third-layer lesions were definitive with jumbo biopsy forceps in 56 of 86 lesions (65.1%) and with FNA in 6 of 16 lesions (37.5%) (P = .047). For fourth-layer lesions, the results with jumbo biopsy forceps were definitive in 10 of 25 (40.0%) and with FNA in 8 of 14 (57.1%) (P = .330). Forty-five of 129 patients (34.9%) experienced significant bleeding after biopsy with jumbo forceps and required some form of endoscopic hemostasis. Retrospective study. Jumbo forceps are a useful tool for the definitive diagnosis of subepithelial lesions. The greatest benefit appears to be with third-layer (submucosal) lesions. The risk of bleeding is significant. Copyright © 2012 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.

  12. Molecular Detection of H. pylori Using Adherent Gastric Mucous to Biopsy Forceps.

    Science.gov (United States)

    Matsumoto, Hiroshi; Shiotani, Akiko; Nishibayashi, Hiroyuki; Kamada, Tomoari; Kimura, Tomonari; Fujimura, Yoshinori; Nakato, Rui; Murao, Takahisa; Fujita, Minoru; Haruma, Ken

    2016-12-01

    We assessed whether adherent gastric mucous to biopsy forceps instead of biopsy samples was suitable for the diagnosis of H. pylori infection. We confirmed the PCR methods to improve the diagnosis of H. pylori infection and clarithromycin (CAM) susceptibility. Gastric mucous was obtained by gently scraping gastric mucosa using biopsy forceps in patients undergoing upper gastrointestinal (GI) endoscopy for PCR and rapid urease test (RUT). DNA was extracted from gastric mucous present within the gel of RUT. H. pylori status and CAM susceptibility were evaluated using H. pylori-specific PCR amplification for 23S rRNA using 4 different primer sets and 16S rRNA. H. pylori positive was defined as two of the three tests (serum antibody, histology, and RUT or PCR) were positive. CAM susceptibility was evaluated by point mutations (A 2142G and A 2143G of 23S rRNA). Samples taken from 494 subjects were evaluated: 300 H. pylori-positive patients and 194 negative patients. The results of PCR using DNA extracted from gastric mucous present within the RUT gel were consistent with those within water. The accuracy of 23S rRNA PCR for H. pylori detection using RUT samples was superior to the other tests. The frequency of CAM resistance was 38.9%, and eradication rate was 91.3% in the patients with wild-type and 47.0% in the patients with the mutant strains. Adherent gastric mucous to biopsy forceps in RUT gel can be used for molecular testing to confirm the diagnosis of H. pylori infection and for CAM susceptibility. © 2016 John Wiley & Sons Ltd.

  13. Forceps versus snare polypectomies in colorectal cancer screening: are we adhering to the guidelines?

    Science.gov (United States)

    Britto-Arias, Martha; Waldmann, Elisabeth; Jeschek, Philip; Gessl, Irina; Sallinger, Daniela; Bannert, Christina; Weber, Michael; Trauner, Michael; Weiss, Werner; Ferlitsch, Arnulf; Ferlitsch, Monika

    2015-10-01

    European guidelines for quality assurance in colorectal cancer screening recommend snare resection for polyps > 5 mm. The aim of this study was to investigate polypectomy technique according to lesion size and shape, and to assess adherence of endoscopists enrolled in the national quality assurance program to the European guidelines. This cohort study included screening colonoscopies performed between 2007 and 2013 within a quality assurance program in Austria. Resection technique was analyzed according to lesion characteristics and endoscopy facility (private practices, hospitals, outpatient clinics) before publication of the EU guidelines (2007 - 2010) and adherence to the guidelines after publication (2011 - 2013). All surveillance colonoscopies and examinations with missing data were excluded. A total of 128 969 screening colonoscopies performed by 278 endoscopy units were included. The polyp detection rate was 39.6 % (n = 47 797) and 95.6 % of polyps were resected. Of polyps ≥ 5 mm, 46.0 % were resected using forceps and were therefore not treated in accordance with the guidelines. Forceps polypectomy of lesions 5 - 10 mm and > 10 mm decreased significantly in hospitals after implementation of the guidelines (both P guidelines, and for polyps > 10 mm forceps usage even increased (P guidelines (51.9 % vs. 53.5 %; P = 0.161). This study confirmed the importance of the European guidelines. The inclusion of adequate resection technique as a quality indicator in colorectal cancer screening programs is recommended. © Georg Thieme Verlag KG Stuttgart · New York.

  14. Penalaran Proporsional Siswa Kelas VII

    Directory of Open Access Journals (Sweden)

    Yandika Nugraha

    2016-10-01

    Full Text Available [Bahasa]: Penelitian ini merupakan penelitian kualitatif deskriptif yang bertujuan untuk mendeskripsikan karakteristik penalaran proporsional siswa. Subjek penelitian adalah siswa kelas VII SMP Negeri 1 Tasikmadu Kabupaten Karanganyar. Prosedur pemilihan subjek dengan cara purposive sampling. Pengumpulan data dilakukan dengan cara think aloud method. Validitas data menggunakan triangulasi waktu. Teknik analisis data dilakukan dengan cara: (1 mengelompokkan data dalam 2 kategori, kemudian mereduksi data yang tidak termasuk dalam 2 kategori tersebut, (2 menyajikan data dalam teks naratif, dan (3 menyimpulkan karakteristik penalaran proporsional siswa kemudian membandingkan subjek yang berada pada level yang sama. Berdasarkan penelitian yang dilakukan pada enam subjek siswa kelas VII SMP Negeri Tasikmadu, terdapat empat siswa yang sudah bisa bernalar kuantitatif yaitu mampu memanipulasi situasi perbandingan dengan menggunakan suatu bilangan dan dua siswa menggunakan perkalian silang tetapi tidak sepenuhnya memahami hubungan invarian dan kovarian. [English]: This descriptive qualitative research is aimed at describing the characteristics of students proportional reasoning. The subjects are the seventh grade students at SMP Negeri 1 Tasikmadu Karanganyar. The subjects are selected through purposive sampling methods. Data collection applies think aloud method. Time triangulation is used for data validation. Data is analyzed by: (1 classifying data in two categories then reducing them which do not belong to both categories, (2 presenting the data in narrative text, and (3 summarizing the characteristics of students proportional reasoning then comparing the subjects based on same level. The research shows that 4 of 6 students are able to reason quantitatively which mean that they can manipulate the proportional situation using number and the remaining students use cross product but they did not fully understand about the relation of invariant and

  15. Application of calibrated forceps for assessing mechanical nociception with high time resolution in mice.

    Science.gov (United States)

    Kashiwadani, Hideki; Kanmura, Yuichi; Kuwaki, Tomoyuki

    2017-01-01

    In order to investigate the basic physiological mechanisms of pain and the anti-nociceptive effects of analgesics, development of pain assays in mice is critical due to the advances of genetic manipulation techniques. The von Frey hairs/Semmes-Weinstein monofilaments test (von Frey test) has long been applied to examine mechanical nociception in mice. Though the von Frey test is a well-established and standardized method, it is inappropriate to assess a rapid change in the nociceptive threshold because voluntary resting/sleeping states are necessary to examine the response. In this study, we assessed the effectiveness of calibrated forceps to determine the mechanical nociceptive threshold in mice. Repeated daily measurements of the threshold over 5 days indicated that the device obtained stable and reliable values. Furthermore, repeated measurements with 5 minute intervals revealed that the device detected the rapid change of the threshold induced by remifentanil, a short-acting μ-receptor agonist. These results indicate that the calibrated forceps are well-suited for measuring the mechanical nociceptive threshold in mice, and are useful in assessing the effects of short-acting analgesics on mechanical nociception.

  16. Image recognition of triangular tissue of an organ pulled by forceps in surgical working area for laparoscope robot.

    Science.gov (United States)

    Nakasuji, Hisa; Naruki, Kazuki; Kawai, Toshikazu; Nishikawa, Atsushi; Nishizawa, Yuji; Nakamura, Tatsuo

    2017-07-01

    An image processing method using selected corner points and ridge lines to recognize triangular tissue of an organ pulled by forceps in a laparoscopic view has been developed. The proposed method could be used for semi-automatic control of a laparoscope robot. It makes use of a masking process based on the recognition of the forceps and clots, detection of corner points for a Delaunay diagram, detection of ridge lines oriented in the same direction, and recognition of the triangular working area. Triangles recognized in laparoscopic surgical videos using this method were similar to the correct triangles made by an endoscopic specialist.

  17. Tracheal intubation in patients with anticipated difficult airway using Boedeker intubation forceps and McGrath videolaryngoscope

    DEFF Research Database (Denmark)

    Strøm, C; Barnung, S; Kristensen, M S

    2015-01-01

    BACKGROUND: Videolaryngoscopes with sharp angulated blades improve the view of the vocal cords but this does not necessarily result in higher success rates of intubation The aim of this study was to evaluate the efficacy of using Boedeker intubation forceps in conjunction with McGrath Series 5 Vi...... by using a styletted tube. CONCLUSION(S): Most patients with anticipated difficult intubation can be successfully intubated with Boedeker intubation forceps and MVL. However, endotracheal tube placement failed in 3/25 patients despite a good laryngeal view....

  18. Spring performance tester for miniature extension springs

    Science.gov (United States)

    Salzbrenner, Bradley; Boyce, Brad

    2017-05-16

    A spring performance tester and method of testing a spring are disclosed that has improved accuracy and precision over prior art spring testers. The tester can perform static and cyclic testing. The spring tester can provide validation for product acceptance as well as test for cyclic degradation of springs, such as the change in the spring rate and fatigue failure.

  19. Extraction of Tc(VII) and Re(VII) on TRU resin

    Energy Technology Data Exchange (ETDEWEB)

    Guerin, Nicolas; Riopel, Remi; Kramer-Tremblay, Sheila [Canadian Nuclear Laboratories (CNL), Chalk River, ON (Canada). Radiobiology and Health Branch; De Silva, Nimal; Cornett, Jack [Ottawa Univ., ON (Canada). Dept. of Earth and Environmental Sciences; Dai, Xiongxin [China Institute for Radiation Protection, Beijing (China)

    2017-06-01

    TRU resin can be used to rapidly and selectively extract Tc(VII) and Re(VII). The retention capacity curves of Tc(VII) and Re(VII) for HNO{sub 3}, HCl, H{sub 2}SO{sub 4} and H{sub 3}PO{sub 4} solutions were studied and prepared. Tc(VII) and Re(VII) were simultaneously extracted in 2 M H{sub 2}SO{sub 4} and 1.5 M H{sub 3}PO{sub 4} and were effectively separated from Mo(VI) and Ru(III). Tc(VII) and Re(VII) remained strongly bonded to the resin even after washing using a large volume of 2 M H{sub 2}SO{sub 4} at a relatively high flow rate. Also, they were both completely eluted from the resin using 15 mL of near boiling water, an eluent directly compatible for ICP-MS instrument measurements.

  20. Percutaneous transluminal forceps biopsy in patients suspected of having malignant biliary obstruction: factors influencing the outcomes of 271 patients

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jung Gu; Jung, Gyoo-Sik; Yun, Jong Hyouk [Kosin University College of Medicine, Department of Radiology, Seo-gu, Busan (Korea, Republic of); Yun, Byung Chul; Lee, Sang Uk; Han, Byung Hoon [Kosin University College of Medicine, Department of Internal Medicine, Busan (Korea, Republic of); Ko, Ji Ho [Busan Medical Center, Department of Radiology, Busan (Korea, Republic of)

    2017-10-15

    To evaluate predictive factors for false-negative diagnosis of percutaneous forceps biopsies in patients suspected of having a malignant biliary obstruction Two hundred seventy one consecutive patients with obstructive jaundice underwent percutaneous forceps biopsy. In each patient, three to five specimens (mean, 3.5 specimens) were collected from the lesion. The final diagnosis for each patient was confirmed with pathologic findings at surgery, additional histocytologic data, or clinical and radiologic follow-up. Univariate and multivariate logistic regression analysis was used to identify risk factors associated with false-negative diagnosis. One hundred ninety four of 271 biopsies resulted in correct diagnoses of malignancy, while 20 biopsy diagnoses were proved to be true-negative. There were 57 false-negative diagnoses and no false-positive diagnoses. The diagnostic performance of transluminal forceps biopsy in malignant biliary obstructions was as follows: sensitivity, 77.2%; specificity, 100%; and accuracy, 78.9%; positive predictive value, 100%, negative predictive value; 25.9%. Periampullary segment of common bile duct, intrahepatic bile duct and metastatic disease were the significant risk factors of false-negative diagnosis. Percutaneous forceps biopsy provides relatively high accuracy in the diagnosis of malignant biliary obstructions. The predictive factors of false-negative biopsy were determined to be biopsy site and origin of primary tumour. (orig.)

  1. Removal of intraocular foreign body in anterior chamber angle with prism contact lens and 23-gauge foreign body forceps.

    Science.gov (United States)

    Huang, Yan-Ming; Yan, Hua; Cai, Jin-Hong; Li, Hai-Bo

    2017-01-01

    To introduce a novel approach in removal of anterior chamber angle foreign body (ACFB) using a prism contact lens and 23-gauge foreign body forceps. Data of 42 eyes of 42 patients who had undergone removal of ACFB using a prism contact lens and 23-gauge foreign body forceps from January 2008 to October 2013 were collected and analyzed. Twenty eyes in group A received the conventional approach by using toothed forceps through corneal limbus incision, and 22 eyes in group B underwent the novel method through the opposite corneal limbus incision. The success rate of ACFB once removal was 75% (15/20) in group A, and 100% (22/22) in group B. The average operation time of group A was significantly longer compared with group B (34.9±9.88min vs 22.13±8.85min; P<0.05). The average size of corneal limbus incision in group A was significantly larger than that of group B (4.85±1.89 mm vs 3.95±1.17 mm; P<0.05). The corneal limbus incision suturing were conducted in all eyes in group A, and only 5 eyes in group B. Removal of ACFB using a prism contact lens and 23-gauge foreign body forceps is a safer, more effective, and convenient technique compared with the conventional approach.

  2. Randomized clinical trial of BiClamp forceps versus clamp-crushing technique in open liver resection.

    Science.gov (United States)

    Chen, Jiang Ming; Geng, Wei; Zhang, Song; Liu, Fu Bao; Zhao, Hong Chuan; Zhao, Yi Jun; Wang, Guo Bin; Xie, Sheng Xue; Geng, Xiao Ping

    2017-03-01

    The aim of this trial was to compare the efficacy and safety of BiClamp forceps with the "gold-standard" clamp-crushing technique for open liver resection. From October 2014 to May 2016, 86 consecutive patients scheduled to undergo hepatic resection were randomized to a BiClamp forceps group (n = 43) or to a clamp-crushing technique group (n = 43). Background characteristics of the two groups were closely matched. There were no significant differences between the BiClamp forceps group and clamp-crushing group in total intraoperative blood loss (339.81 ± 257.20 ml vs. 376.73 ± 303.67 ml, respectively; P = 0.545) or blood loss per transection area (5.35 ± 3.27 ml/cm2 vs. 5.44 ± 3.02 ml/cm2 , respectively; P = 0.609). Liver transection speed, the need of blood transfusion, morbidity, length of postoperative hospital stay, total hospitalization cost and liver function recovery were similar in the two groups. Multivariate logistic regression analysis identified major hepatectomy, multiple resections and liver transection time ≥30 min as significantly unfavorable factors for decreased intraoperative blood loss. Liver parenchymal transection with BiClamp forceps is as safe and feasible as the gold-standard clamp-crushing technique. © 2017 Japanese Society of Hepato-Biliary-Pancreatic Surgery.

  3. [Safety and validity of port-less forceps in reduced-port surgery for laparoscopic resection of colorectal cancer].

    Science.gov (United States)

    Okamura, Shu; Murata, Kohei; Wada, Yuma; Kato, Ryo; Makino, Shunichiro; Takeoka, Tomohira; Okada, Kazuyuki; Yanagisawa, Tetsu; Fukuchi, Nariaki; Ebisui, Chikara; Yokouchi, Hideoki; Kinuta, Masakatsu

    2013-11-01

    The purpose of this study was to examine the safety and validity of reduced-port surgery( RPS) in comparison with conventional laparoscopic surgery for colorectal cancer. We investigated 64 cases of colorectal cancer( CRC) resected by laparoscopic surgery at our hospital in 2012, including 22 cases resected by RPS using 1 or more port-less forceps( Endo Relief, Hope Electronics, Japan). With regard to safety, Endo Relief yielded satisfactory outcomes in terms of the limitations of other needlescopic devices, such as lack of strength and risk of tissue injury, while maintaining countertraction. In addition to the original reasons for introducing RPS, such as lessening wound pain and improving the cosmetic outcome after surgery, the advantages of RPS for CRC are high cost efficiency and the possibility of using additional forceps to maintain triangulation or countertraction during laparoscopic surgery. Because it involves a port-less system, RPS facilitates the frequent reuse of forceps, thereby contributing to its high cost efficiency. In the introduction of RPS for laparoscopic colorectal resection, the use of port-less forceps for countertraction could be safe and effective.

  4. Development of optical guiding forceps for a direct bonding system using lightcured resin adhesives.

    Science.gov (United States)

    Kameda, Takashi; Ohkuma, Kazuo; Sano, Natsuki; Terada, Kazuto

    2014-01-01

    Multi-bracket systems are popular orthodontic appliances and are commonly bonded directly to enamel surfaces by resin adhesives. In light-cured bonding, the tip of the curing unit must be kept at a distance from the adhesive on the tooth, which can lead to low polymerization and insufficient bond strength. The curing lights also generate low-frequency electromagnetic fields, which can be harmful to patient health. Furthermore, bacterial contamination of the light-curing tips during use presents an infection risk for patients. In this study, we describe the development of optical guiding forceps (OGFs) for polymerizing light-cured resin as a solution to these problems. With OGFs, polymerization of adhesives was deeper than with lower magnetic fields and the bonds had the same shear strength as those formed by conventional procedures. These results suggest that OGFs may have practical use in the direct bonding of orthodontic appliances as well as in provisional bonding.

  5. [Kiwi vacuum extractor versus forceps and spatula: maternal and fetal morbidity evaluation in 169 fetal extractions].

    Science.gov (United States)

    Werkoff, G; Morel, O; Desfeux, P; Gayat, E; Akerman, G; Tulpin, L; Malartic, C; Barranger, E

    2010-11-01

    To evaluate maternal and fetal complications resulting from the use of the Kiwi vacuum extractor and to compare them with those resulting from the use of forceps or spatula. Patients who had instrumental extraction between November 2006 and April 2007 were included in a unicentric retrospective study. Complications resulting from the use of Kiwi vacuum extractor and those of other instruments were compared. One hundred and sixty-nine patients where included, 79 had extraction with Kiwi vacuum extractor. The two populations (women having extraction with Kiwi and woman having extraction with spatula or forceps) were similar in terms of maternal characteristics, progress of labour and delivery. The rate of episiotomies was significantly lower with KIWI (73.1% versus 94.4%; P=0.0001), as well as was postpartum haemorrhage rate (8.9 % versus 18.9%; P=0.04). No perineal tear of second or third degree occurred with Kiwi. Kiwi vacuum extractor was associated with a higher rate of shoulder dystocia (12.8% versus 6.7%, NS), but related fetal complication rates were similar in the two groups. The extraction failure rate was significantly higher with Kiwi (11.4% versus 4.4%; P=0.04), but cesarean section rate was similar for the two groups (1.3 % versus 4.4%). This study is the first comparing complications occurring after extraction with KIWI vacuum extractor to those occurring with other instruments. Although the results are limited by the retrospective nature of the study and the small size of the workforce, our study suggests that Kiwi vacuum extractor is associated with a lower rate of maternal complications and a rate of fetal complication similar to other kind of instruments. This instrument should be promoted and taught to younger patricians. Our study also revealed higher failure and shoulder dystocia rates. Larger studies are needed to better evaluate risks factor concerning these two complications in order to optimise the use of Kiwi vacuum extractor. Copyright

  6. Right Forceps Minor and Anterior Thalamic Radiation Predict Executive Function Skills in Young Bilingual Adults

    Directory of Open Access Journals (Sweden)

    Ping C. Mamiya

    2018-02-01

    Full Text Available Executive function (EF skills enhance learning across domains, and are particularly linked to the acquisition of a second language. Previous studies have shown that bilingual individuals show enhanced EF skills in cognitive tasks where they attended a targeted dimension of a stimulus while inhibiting other competing cues. Brain imaging revealed that bilingual young adults’ performances in the Stroop color-naming task were related to the volume of anterior cingulate cortex (ACC and inferior frontal lobe. Subjects who had greater white-matter in the frontal cortex showed enhanced performances in the same task, suggesting that brain fiber pathways connecting ACC to the frontal region may be related to the Stroop color-naming task. No studies to date have examined the tissue properties of brain fiber pathways connecting these brain regions and their association with subjects’ EF performances. Importantly, there are no data establishing whether bilingual subjects exhibit different reaction times when words are presented in their first versus second language. To study these questions, we used behavioral and unbiased whole-brain analyses, recruiting 21 Chinese students. Using the Stroop color-naming task, we measured subjects’ reaction times (RTs in which color names were displayed using fonts that matched the named color (congruent task or mismatched the color (incongruent task. Students performed the task twice, first in English, the subjects’ second language, then in Chinese, the subjects’ primary language. Results from whole-brain analysis showed that students’ RTs in both the English and Chinese tasks were significantly correlated with the mode of anisotropy (MO in a brain cluster containing the forceps minor and anterior thalamic radiation in the right hemisphere. We also found that fractional anisotropy (FA significantly predicted students’ RTs, with higher FA predicting shorter RT. Taken together, our findings demonstrate that

  7. Cleveland Bilingual Education Program: Title VII ESEA.

    Science.gov (United States)

    Halasa, Ofelia

    This 1974-75 evaluation report of the Title VII Cleveland Bilingual Education Program discusses the degree to which process objectives were implemented and product objectives attained, and the impressions of project and school staff and parents. The goals of the bilingual program were to develop the ability to communicate and function in Spanish…

  8. Canine specific ELISA for coagulation factor VII

    DEFF Research Database (Denmark)

    Knudsen, Tom; Kjelgaard-Hansen, Mads; Tranholm, Mikael

    2011-01-01

    Canine coagulation factor VII (FVII) deficiency can be hereditary or acquired and may cause life threatening bleeding episodes if untreated. FVII procoagulant activity can be measured by FVII activity (FVII:C), but assays for measurement of canine specific FVII antigen (FVII:Ag) have not been...

  9. 29 CFR 1601.93 - Opinions-title VII.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Opinions-title VII. 1601.93 Section 1601.93 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURAL REGULATIONS Title VII Interpretations and Opinions by the Commission § 1601.93 Opinions—title VII. Only the following...

  10. Debakey Forceps Crushing Technique for Hepatic Parenchymal Transection in Liver Surgery: A Review of 100 Cases and Ergonomic Advantages

    Directory of Open Access Journals (Sweden)

    Sundeep Jain

    2014-01-01

    Full Text Available Introduction and Objective. Bleeding is an important complication in liver transections. To determine the safety and efficacy of Debakey forceps for liver parenchymal transection and its ergonomic advantages over clamp crushing method we analysed our data. Methods. We used Debakey crushing technique in 100 liver resections and analysed data for transection time, transfusion rate, morbidity, mortality, hospital stay, influence of different types of liver conditions, and ergonomi features of Debakey forceps. Results. Mean age, transection time and hospital stay of 100 patients were 52.38 ± 17.44 years, 63.36 ± 33.4 minutes, and 10.27 ± 5.7 days. Transection time, and hospital stay in patients with cirrhotic liver (130.4 ± 44.4 mins, 14.6 ± 5.5 days and cholestatic liver (75.8 ± 19.7 mins, 16.5 ± 5.1 days were significantly greater than in patients with normal liver (48.1 ± 20.1 mins, 6.7 ± 1.8 days (P<0.01. Transection time improved significantly with experience (first fifty versus second fifty cases—70.2 ± 31.1 mins versus 56.5 ± 34.5 mins, P<0.04. Qualitative evaluation revealed that Debakey forceps had ergonomic advantages over Kelly clamp. Conclusions. Debakey forceps crushing technique is safe and effective for liver parenchymal transection in all kinds of liver. Transection time improves with surgeon’s experience. It has ergonomic advantages over Kelly clamp and is a better choice for liver transection.

  11. Value of forceps biopsy and kyphoplasty in Kümmell's disease.

    Science.gov (United States)

    Wang, Dalin; Wang, Liming; Xu, Jie; Zen, Yiwen; Zheng, Shengnai; Wang, Gangrui

    2013-08-01

    The diagnosis of Kümmell's disease mainly depends on clinical and radiologic findings. However, these are not the gold standards for diagnosing this disease; bone biopsy is required. The authors performed modified bone biopsy and cement-filling techniques during kyphoplasty and investigated the feasibility and efficacy of kyphoplasty for the treatment of Kümmell's disease. This study included 28 patients (9 men and 19 women; average age, 71.9 years) with Kümmell's disease. All patients underwent the modified biopsy procedure and kyphoplasty with the modified cement-filling technique. Treatment efficacy was evaluated using visual analog scale pain scores, Oswestry Disability Index scores, vertebral height, and Cobb angles pre- and postoperatively and at final follow-up. All patients tolerated the procedure well and had immediate back pain relief after kyphoplasty. Biopsy examination revealed necrotic bone in 24 patients and sparse cancellous bone in 2; it was unsuccessful in 2 patients. No severe complication occurred in any patient. Two patients had cement leakage but no clinical symptoms. All efficacy measures were significantly better at the postoperative assessments than the preoperative assessments (PKyphoplasty is a relatively effective and safe method for treating Kümmell's disease when modified techniques are performed to prevent cement leakage, and forceps biopsy can be used in the differential diagnosis of this condition. Copyright 2013, SLACK Incorporated.

  12. Trabeculotomy ab interno with internal limiting membrane forceps for open-angle glaucoma.

    Science.gov (United States)

    Nakasato, Houmei; Uemoto, Riyo; Isozaki, Masaru; Meguro, Akira; Kawagoe, Tatsukata; Mizuki, Nobuhisa

    2014-06-01

    To describe a new technique to perform trabeculotomy ab interno on eyes with open-angle glaucoma (OAG). This was a retrospective study. We inserted a 25-gauge forceps that is usually used for internal limiting membrane peeling into the anterior chamber, and grasped and pulled the inner wall of Schlemm's canal away from the canal. The inner wall of Schlemm's canal was stripped for about 100° to 120° in 26 eyes of 23 patients. The intraocular pressure (IOP) and number of glaucoma medications were recorded before, and 1 day, 1 week, 2 weeks, and 1, 3, 6, 10, 12, 15, 17, 19, 24, 27, 30, and 33 months after the surgery. The intra- and postoperative complications were recorded. The mean ± standard deviation of the preoperative IOP was 20.0 ± 6.8 mmHg with a range from 10 to 38 mmHg (n = 26). The IOP was significantly reduced (P interno for OAG is effective but with some minor complications. A larger number of patients with longer follow-up periods are needed to determine the long-term effectiveness of this procedure.

  13. Application of clips assisted with foreign body forceps in defect closure after endoscopic full-thickness resection.

    Science.gov (United States)

    Tang, An-Liu; Liao, Xiang-Qi; Shen, Shou-Rong; Xiao, Ding-Hua; Yuan, Yun-Xiang; Wang, Xiao-Yan

    2016-05-01

    This study was designed to evaluate the feasibility and efficacy of metallic clips assisted with foreign body forceps closing the gastric wall defect after endoscopic full-thickness resection (EFR) for gastric submucosal tumors (SMTs). Eighteen patients with gastric SMTs originated from the muscularis propria were treated by EFR between September 2012 and June 2014. Twelve patients underwent endoscopic closure of the gastric wall defects after EFR with endoloop and metallic clips (endoloop string suture method, ESSM), and six patients with clips and foreign body forceps (clips assisted with foreign body forceps clip method, CFCM). No significant differences existed between the two groups in terms of demographics, clinical characteristics, and the size of the gastric wall defects. The average time spent in closing the gastric wall defects (14.83 ± 1.94 min for the CFCM group and 22.42 ± 5.73 min for the ESSM group) and hospitalization fees of the CFCM group were significantly lower than those of the ESSM group. The average hospitalization time of the two groups had no statistical significance. No single case had surgical intervention or complications, such as gastric bleeding, perforation, peritonitis, or abdominal abscess. The CFCM and the ESSM are safe and effective techniques for gastric defect closure after EFR for gastric SMTs. Because of the "chopsticks effect," the CFCM more suitable for the lesions located at the gastric fundus, the greater curvature or anterior wall of the gastric body and gastric antrum.

  14. Debakey forceps crushing technique for hepatic parenchymal transection in liver surgery: a review of 100 cases and ergonomic advantages.

    Science.gov (United States)

    Jain, Sundeep; Sharma, Bharat; Kaushik, Mitesh; Jain, Lokendra

    2014-01-01

    Introduction and Objective. Bleeding is an important complication in liver transections. To determine the safety and efficacy of Debakey forceps for liver parenchymal transection and its ergonomic advantages over clamp crushing method we analysed our data. Methods. We used Debakey crushing technique in 100 liver resections and analysed data for transection time, transfusion rate, morbidity, mortality, hospital stay, influence of different types of liver conditions, and ergonomi features of Debakey forceps. Results. Mean age, transection time and hospital stay of 100 patients were 52.38 ± 17.44 years, 63.36 ± 33.4 minutes, and 10.27 ± 5.7 days. Transection time, and hospital stay in patients with cirrhotic liver (130.4 ± 44.4 mins, 14.6 ± 5.5 days) and cholestatic liver (75.8 ± 19.7 mins, 16.5 ± 5.1 days) were significantly greater than in patients with normal liver (48.1 ± 20.1 mins, 6.7 ± 1.8 days) (P advantages over Kelly clamp. Conclusions. Debakey forceps crushing technique is safe and effective for liver parenchymal transection in all kinds of liver. Transection time improves with surgeon's experience. It has ergonomic advantages over Kelly clamp and is a better choice for liver transection.

  15. Can we improve the biopsy quality of upper urinary tract urothelial tumors? Single-center preliminary results of a new biopsy forceps.

    Science.gov (United States)

    Al-Qahtani, Saeed M; Legraverend, Dorian; Gil-Diez de Medina, Sixtina; Sibony, Mathilde; Traxer, Olivier

    2014-01-01

    Our aim was to evaluate the biopsy quality of upper urinary tract urothelial transitional cell carcinoma with a new biopsy forceps (BIGopsy®, Cook Medical) compared to a classic biopsy forceps (Piranha®, Boston Scientific). From December 2009 to December 2011, 20 patients with upper urinary tract urothelial transitional cell carcinoma underwent conservative treatment endoscopically. All lesions were evaluated and biopsied with 3 Fr cup forceps using both types of forceps (BIGopsy and Piranha). A single pathologist blindly analyzed the specimens in order to determine the optimal biopsy for each patient. Specimen histopathology results were graded; however, they were staged if the lamina propria was not invaded (T1) or if the tumor was detected at the lamina propria (T1+). Of the 20 upper urinary tract lesions, 12 (60%) were in the renal pelvis, 3 (15%) in the upper calyx, 1 (5%) in the middle calyx, 1 (5%) in the lower calyx, 1 (5%) in the upper third of the ureter and 2 (10%) in the middle third of the ureter. We did not detect T1 in all biopsies. One patient had no valid biopsies by both forceps. A diagnosis of urothelial carcinoma was made in 17 BIGopsy biopsies compared to 7 Piranha biopsies. Despite the limited number of cases, our study demonstrated the advantage of the new forceps (BIGopsy) in obtaining a valid biopsy of upper urinary tract urothelial tumors. Therefore, we recommend it in evaluating this pathology for optimal treatment. © 2014 S. Karger AG, Basel.

  16. Esophageal Endoscopic Submucosal Dissection Assisted by an Overtube with a Traction Forceps: An Animal Study

    Directory of Open Access Journals (Sweden)

    Ken Ohata

    2016-01-01

    Full Text Available Esophageal endoscopic submucosal dissection (ESD is technically difficult. To make it safer, we developed a novel method using overtube with a traction forceps (OTF for countertraction during submucosal dissection. We conducted an ex vivo animal study and compared the clinical outcomes between OTF-ESD and conventional method (C-ESD. A total of 32 esophageal ESD procedures were performed by four beginner and expert endoscopists. After circumferential mucosal incision for the target lesion, structured as the isolated pig esophagus 3 cm long, either C-ESD or OTF-ESD was randomly selected for submucosal dissection. All the ESD procedures were completed as en bloc resections, while perforation only occurred in a beginner’s C-ESD procedure. The dissection time for OTF-ESD was significantly shorter than that for C-ESD for both the beginner and expert endoscopists (22.8±8.3 min versus 7.8±4.5 min, P<0.001, and 11.3±4.4 min versus 5.9±2.5 min, P=0.01, resp.. The frequency and volume of the submucosal injections were significantly smaller for OTF-ESD than for C-ESD (1.3±0.6 times versus 2.9±1.5 times, P<0.001, and 5.3±2.8 mL versus 15.6±7.3 mL, P<0.001, resp.. Histologically, muscular injury was more common among the C-ESD procedures (80% versus 13%, P=0.009. Our results indicated that the OTF-ESD technique is useful for the safe and easy completion of esophageal ESD.

  17. Percutaneous tracheostomy: Ciaglia Blue Rhino versus Griggs' Guide Wire Dilating Forceps. A prospective randomized trial.

    Science.gov (United States)

    Añón, J M; Escuela, M P; Gómez, V; Moreno, A; López, J; Díaz, R; Montejo, J C; Sirgo, G; Hernández, G; Martínez, R

    2004-04-01

    Percutaneous tracheostomy (PT) has gained widespread acceptance to control the airway in patients requiring prolonged mechanical ventilation. Since 1985, new techniques for PT have been described. It was the aim of this investigation to compare two different PT techniques: the Ciaglia Blue Rhino (CBR) and the Guide Wire Dilating Forceps (GWDF). A prospective randomized trial was performed in four intensive care units. After informed consent, 53 consecutive patients were randomized to undergo CBR or GWDF. Procedural complications were evaluated and specific symptoms of the upper airway tract in survivors were assessed. Twenty-seven patients were randomly assigned to CBR and 26 to GWDF. Patients mean ages were 62.7 +/- 15.8 years and 62.2 +/- 18.3, respectively. Mean APACHE II scores were 20.6 +/- 6.8 and 21.2 +/- 7.2, respectively. Median duration of the procedure was 7 min (range: 4-17 min) with GWDF and 9 min (range: 5-32 min) with CBR (P = 0.16). Seven patients in the group undergoing GWDF had complications (desaturation: two; mild bleeding: one; infected stoma: one; inability to complete the procedure: three). Two patients had complications in the group undergoing CBR (mild bleeding) (P = 0.07). Survivors were followed up after discharge. Three patients (all of them having undergone GWDF) were symptomatic (two with mild hoarseness and one with a persistent foreign body sensation), but laryngotracheoscopy was negative. Our results show no differences between both techniques regarding surgical duration or procedural complications. Late symptoms were encountered in three patients undergoing GWDF, however, laryngotracheoscopy failed to document anatomical or functional abnormalities.

  18. Intrapartum transperineal ultrasound used to predict cases of complicated operative (vacuum and forceps) deliveries in nulliparous women.

    Science.gov (United States)

    Sainz, José A; García-Mejido, José A; Aquise, Adriana; Bonomi, María J; Borrero, Carlota; De La Fuente, Paloma; Fernández-Palacín, Ana

    2017-12-01

    The objective of this study was to investigate the predictive value of intrapartum transperineal ultrasound in the identification of complicated operative (vacuum or forceps) deliveries in nulliparous women. Prospective observational study of nulliparous women with an indication for operative delivery who underwent intrapartum transperineal ultrasound before fetal extraction. Managing obstetricians were blinded to the ultrasound data. Intrapartum transperineal ultrasound was performed immediately before blade application, both at rest and concurrently with contractions and active pushing. Operative delivery was classified as complicated when one or more of the following situations occurred: three or more tractions; a third-/fourth-degree perineal tear; significant bleeding during the episiotomy repair; major tear or significant traumatic neonatal lesion. A total of 143 nulliparous women were included in the study (82 vacuum-assisted deliveries and 61 forceps-assisted deliveries), with 20 fetuses in occiput posterior position. Forty-seven operative deliveries were classified as complicated deliveries (28 vacuum-assisted deliveries, 19 forceps-assisted deliveries). No differences in obstetric, intrapartum or neonatal characteristics were observed between the study groups, with the following exceptions: birthweight (3229 ± 482 uncomplicated deliveries vs. 3623 ± 406 complicated deliveries; p operating characteristics curve (AUC), were the angle of progression with active pushing (AoP2) (AUC 86.9%) and the progression distance with active pushing (PD2) (AUC 74.5%). The optimal cut-off value for predicting a difficult operative delivery was an AoP2 of 153.5° (sensitivity 95.2%; false-positive rate 5.9%) or PD2 of 58.5 mm (sensitivity 95.2%; false-positive rate 7.1%). The sonographic parameters AoP2 and PD2 can be used to predict cases of complicated operative deliveries in nulliparous women. © 2017 Nordic Federation of Societies of Obstetrics and Gynecology.

  19. A Rare Incidence of Breakage of tip of Micropituitary Forceps during Percutaneous Discectomy - How to Remove it: A Case Report

    Directory of Open Access Journals (Sweden)

    Sureisen M

    2015-11-01

    Full Text Available Breakage of the tip of the micropituitary forceps during spine surgery is a rare occurrence. Retrieval of the broken tip could be a challenge in minimally invasive surgeries due to limitation of access and retrieval instruments. We describe our experience in handling such a situation during percutaneous radiofrequency discectomy. The removal was attempted, without converting into open surgery, by utilising percutaneous endoscopic lumbar discectomy working cannula and guided by image intensifier. We were able to remove the fragment without any significant morbidity to the patient. This technique for removal has not been reported previously in the literature.

  20. Polyps in the gastrointestinal tract: discrepancy between endoscopic forceps biopsies and resected specimens.

    Science.gov (United States)

    Sung, Hye Young; Cheung, Dae Young; Cho, Se-Hyun; Kim, Jin Il; Park, Soo-Heon; Han, Joon-Yeol; Park, Gyeong Sin; Kim, Jae Kwang; Chung, In-Sik

    2009-02-01

    An endoscopic forceps biopsy (EFB) carries the risk of missing the neoplastic foci within a polyp as only a small portion of the lesion is sampled using this technique. Accordingly, the histological examination of specimens obtained by an EFB is of limited accuracy and patient management based on the histological findings is controversial. The aim of this prospective study was to determine the diagnostic concordance between an EFB and resected tissues of gastric and colon polyps. Between January 2006 and October 2007, 1312 gastrointestinal polyps from 896 patients were resected in our hospital. Patients with polyps of epithelial origin of at least 8 mm in diameter and not associated with polyposis syndromes were included in the study. Polyps of nonepithelial origin were excluded. One thousand two hundred and sixty-four polyps of epithelial origin [gastric polyps (n=268) and colon polyps (n=996)] obtained from 813 patients met the inclusion criteria. All patients underwent an EFB and resection of the polyp by endoscopic mucosal resection and endoscopic submucosal dissection. Multiple polyps existed in 31.6% of the patients. The pathological diagnoses of resected gastric polyps were as follows: adenomas with low-grade dysplasia, 46 (17.2%); adenomas with high-grade dysplasia, 42 (15.7%); hyperplastic polyps, 126 (47.0%); chronic inflammatory polyps, 29 (10.8%); and adenocarcinomas, 25 (9.3%). The discrepancy rate between an EFB and the pathology of the resected gastric polyps was 39.2% (the Kendall's tau-b and the kappa coefficient for agreement between the EFB and resected specimens of gastric polyps were 0.577 and 0.472, respectively; P value polyp and the concordance rate was observed. The pathological diagnoses of the resected colon polyps were as follows: adenomas with low-grade dysplasia, 559 (56.1%); adenomas with high-grade dysplasia, 229 (23.0%); hyperplastic polyps, 44 (4.4%); adenocarcinomas, 53 (5.3%); and inflammatory polyps, 111 (11.1%). The discrepancy

  1. Compact forceps manipulator with a spherical-coordinate linear and circular telescopic rail mechanism for endoscopic surgery.

    Science.gov (United States)

    Kawai, Toshikazu; Hayashi, Hiroyuki; Nishizawa, Yuji; Nishikawa, Atsushi; Nakamura, Ryoichi; Kawahira, Hiroshi; Ito, Masaaki; Nakamura, Tatsuo

    2017-08-01

    By integrating locally operated small surgical robots in a sterilized area, a surgeon can perform safe and accurate robotically assisted laparoscopic surgery. At present, there is no locally operated compact forceps robot that can operate within a small space while providing a wide working area on the abdominal wall. In the present study, a new spherical-coordinate manipulator with a linear telescopic rail and two circular telescopic rails that can act as a third arm for the surgeon has been developed. A compact locally operated detachable end-effector manipulator (LODEM) was developed. This manipulator uses circular telescopic rails with linkage mechanisms for the yaw and pitch axes, and a linear telescopic rail for the insertion/extraction axis is attached to forceps. The dimensions of the manipulator are [Formula: see text] when contracted and [Formula: see text] when expanded. The positional accuracy, mechanical deflection, and backlash of the prototype were evaluated while performing simulated in vivo laparoscopic surgery. The positional accuracy, deflection, and backlash of the telescopic rail mechanism were 2.1, 1.8, and 5.1 mm, respectively. The manipulator could successfully handle the target and maintain stability, while the arms of the endoscope specialist were free from collisions with the manipulator during an in vivo laparoscopic surgery. A compact LODEM was designed to facilitate minimally invasive, robotically assisted laparoscopic surgery by a doctor working near the patient. This device could be used for such applications.

  2. Development of a flow cytometric method to determine DNA ploidy of oesophageal cancer cells obtained by forceps biopsy samples during oesophago-gastro-duodenoscopy.

    Science.gov (United States)

    Rickes, S; Hauptmann, S; Flath, B; Abbenseth, R; Zwiebel, F M; Possinger, K

    2003-02-01

    The DNA content of oesophageal tumour cells is a prognostic factor in untreated patients. To investigate whether DNA ploidy is useful to select patients for neoadjuvant therapy it is of interest to develop a method allowing reliable flow cytometric analysis of the DNA content of tumour cells obtained by forceps biopsy during endoscopy before start of therapy. Freshly frozen forceps biopsy samples from 30 patients with oesophageal cancer were disaggregated. DNA was stained with propidium iodide and ploidy was determined by flow cytometry. To enhance sensitivity epithelial cells were simultaneously labelled with anti-cytokeratin antibodies. Results were compared with image analysis. To evaluate the sampling error, parallel measurements were done in 10 patients by image analysis on forceps biopsies obtained during endoscopy before surgery and on the resected tumour. The sensitivity to detect aneuploidy was lower for standard flow cytometry than for image analysis (13 versus 33%). The overall sensitivities were identical using a double labelling technique with additional cytokeratin-staining of the epithelial cells, but divergent results were obtained in 2 cases, where detection of aneuploidy was either possible with image analysis or with double labelling flow cytometry only. DNA content of samples gained by forceps biopsies and surgically resected tumours was concordant in 8 of 10 cases. In 2 patients, aneuploidy was detected only in the surgically resected tumour but not in the pre-operatively obtained forceps biopsies. A flow cytometric method for routine determination of the DNA ploidy of cells obtained by forceps biopsies from patients with oesophageal cancer was developed and evaluated against image analysis. The technique allows the prediction of DNA content before tumour resection, and might be used for optimising therapy and the patient's quality of live. Copyright 2003 S. Karger GmbH, Freiburg

  3. Frederik VII og folkets kærlighed

    DEFF Research Database (Denmark)

    Perlt, Michael; Vinding, Niels Valdemar

    2013-01-01

    I den turbulente tid mellem de to slesvigske krige drog kong Frederik VII under en rejse til Jylland i 1857 i procession op på højene i Jelling for at modtage folkets hyldest. På det historiske sted lod Frederik VII sig fejre som danskernes konge under en stor folkefest med bønder og deres familier...

  4. In silico dissection of Type VII Secretion System components across ...

    Indian Academy of Sciences (India)

    2016-02-12

    Feb 12, 2016 ... [Das C, Ghosh TS and Mande SS 2016 In silico dissection of Type VII Secretion System components across bacteria: New directions towards functional characterization. J. Biosci. 41 133–143] DOI 10.1007/s12038-016-9599-8. 1. Introduction. Type VII Secretion System (T7SS) was first identified in.

  5. [A case of polypoid bronchial neurofibroma originating from right B2b successfully treated by bronchoscopic snaring forceps and Nd-YAG laser therapy].

    Science.gov (United States)

    Takiguchi, Y; Uchiyama, T; Sato, K; Tatsumi, K; Kimura, H; Nagao, K; Fujisawa, T; Ohwada, H; Hiroshima, K; Kuriyama, T

    1993-12-01

    A 34-year-old man with persistent cough was admitted to our hospital. Bronchoscopic examination revealed a polypoid tumor with smooth surface which almost completely obstructed the right main bronchus. The tumor was removed by transbronchial snaring forceps and histologically confirmed as neurofibroma. Residual tumor was excised by biopsy forceps and further endoscopic Nd-YAG laser vaporization was performed. This is the first case in our country in which bronchoscopic treatment was performed for bronchial neurofibroma. Bronchoscopic removal might be the preferred treatment in the present case, although long-term follow-up is also required.

  6. Thermal springs of Wyoming

    Energy Technology Data Exchange (ETDEWEB)

    Breckenridge, R.M.; Hinckley, B.S.

    1978-01-01

    This bulletin attempts, first, to provide a comprehensive inventory of the thermal springs of Wyoming; second, to explore the geologic and hydrologic factors producing these springs; and, third, to analyze the springs collectively as an indicator of the geothermal resources of the state. A general discussion of the state's geology and the mechanisms of thermal spring production, along with a brief comparison of Wyoming's springs with worldwide thermal features are included. A discussion of geothermal energy resources, a guide for visitors, and an analysis of the flora of Wyoming's springs follow the spring inventory. The listing and analysis of Wyoming's thermal springs are arranged alphabetically by county. Tabulated data are given on elevation, ownership, access, water temperature, and flow rate. Each spring system is described and its history, general characteristics and uses, geology, hydrology, and chemistry are discussed. (MHR)

  7. Instant Spring Tool Suite

    CERN Document Server

    Chiang, Geoff

    2013-01-01

    Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. A tutorial guide that walks you through how to use the features of Spring Tool Suite using well defined sections for the different parts of Spring.Instant Spring Tool Suite is for novice to intermediate Java developers looking to get a head-start in enterprise application development using Spring Tool Suite and the Spring framework. If you are looking for a guide for effective application development using Spring Tool Suite, then this book is for you.

  8. "Viies aastaaeg" kui voolav ruum / Veronika Valk

    Index Scriptorium Estoniae

    Valk, Veronika, 1976-

    2015-01-01

    Arhitektuurivõistluse eesmärk oli leida Suure-Jaani tervisekeskusele sobivaim lahendus. 2015. aasta sügisel toimunud võistlusele laekus 12 tööd, millest hankija esitatud tingimusele vastas 11. Võitjaks osutus Arhitekt Musta ja Novarci ühistööna valminud kavand "Viies aastaaeg" (autorid: Ott Alver, Alvin Järving, Mari Rass, Gert Guriev, Liina Liis Pihu, Märten Peterson ja Reino Rass). Teise koha sai töö "Polüfoonia" (autorid: Urmo Mets, Kaur Talpsep, Kristiina Aasvee ja Lauri Eltermaa Kauss Arhitektuurist). Kolmanda koha sai töö "Akord" (autorid: Joel Kopli, Koit Ojaliiv ja Rene Sauemägi Amhold/Kuust)

  9. Water Treatment Technology - Springs.

    Science.gov (United States)

    Ross-Harrington, Melinda; Kincaid, G. David

    One of twelve water treatment technology units, this student manual on springs provides instructional materials for two competencies. (The twelve units are designed for a continuing education training course for public water supply operators.) The competencies focus on spring basin construction and spring protection. For each competency, student…

  10. VII NERVE PALSY — EVALUATION AND MANAGEMENT

    African Journals Online (AJOL)

    Enrique

    gold weight implant or upper eyelid spring is indicated. Bell's palsy. The treatment of Bell's remains contro- versial. The effectiveness of any med- ical regimen in altering the natural his- tory of the palsy (85 - 90% complete recovery in 1 month) remains unproven. Despite this, experts believe that early oral prednisone (1 ...

  11. Pro Spring Batch

    CERN Document Server

    Minella, Michael T

    2011-01-01

    Since its release, Spring Framework has transformed virtually every aspect of Java development including web applications, security, aspect-oriented programming, persistence, and messaging. Spring Batch, one of its newer additions, now brings the same familiar Spring idioms to batch processing. Spring Batch addresses the needs of any batch process, from the complex calculations performed in the biggest financial institutions to simple data migrations that occur with many software development projects. Pro Spring Batch is intended to answer three questions: *What? What is batch processing? What

  12. 29 CFR 1601.91 - Request for title VII interpretation or opinion.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Request for title VII interpretation or opinion. 1601.91... PROCEDURAL REGULATIONS Title VII Interpretations and Opinions by the Commission § 1601.91 Request for title VII interpretation or opinion. Any interested person desiring a written title VII interpretation or...

  13. Stark broadening parameter tables for F VI and Cl VII

    Directory of Open Access Journals (Sweden)

    Dimitrijević M.S.

    1998-01-01

    Full Text Available Using a semiclassical approach, we have calculated electron−, proton−, and He III−impact line widths and shifts for 2 F VI and 10 Cl VII multiplets as a function of temperature and perturber density.

  14. Compression Freezing Kinetics of Water to Ice VII

    Science.gov (United States)

    Gleason, A. E.; Bolme, C. A.; Galtier, E.; Lee, H. J.; Granados, E.; Dolan, D. H.; Seagle, C. T.; Ao, T.; Ali, S.; Lazicki, A.; Swift, D.; Celliers, P.; Mao, W. L.

    2017-07-01

    Time-resolved x-ray diffraction (XRD) of compressed liquid water shows transformation to ice VII in 6 nsec, revealing crystallization rather than amorphous solidification during compression freezing. Application of classical nucleation theory indicates heterogeneous nucleation and one-dimensional (e.g., needlelike) growth. These first XRD data demonstrate rapid growth kinetics of ice VII with implications for fundamental physics of diffusion-mediated crystallization and thermodynamic modeling of collision or impact events on ice-rich planetary bodies.

  15. VII Congrés Internacional de Conflictologia i Pau

    OpenAIRE

    Planell Estany, Josep A.

    2014-01-01

    Discurso del rector de la Universitat Oberta de Catalunya, Josep A. Planell, en el VII Congreso Internacional de Conflictología y Paz. Speech by the president of the Universitat Oberta de Catalunya, Josep A. Planell, at the 7th International Congress on Conflictology and Peace. Discurs del rector de la Universitat Oberta de Catalunya, Josep A. Planell, en el VII Congrés Internacional de Conflictologia i Pau.

  16. Spring 5 & reactive streams

    CERN Document Server

    CERN. Geneva; Clozel, Brian

    2017-01-01

    Spring is a framework widely used by the world-wide Java community, and it is also extensively used at CERN. The accelerator control system is constituted of 10 million lines of Java code, spread across more than 1000 projects (jars) developed by 160 software engineers. Around half of this (all server-side Java code) is based on the Spring framework. Warning: the speakers will assume that people attending the seminar are familiar with Java and Spring’s basic concepts. Spring 5.0 and Spring Boot 2.0 updates (45 min) This talk will cover the big ticket items in the 5.0 release of Spring (including Kotlin support, @Nullable and JDK9) and provide an update on Spring Boot 2.0, which is scheduled for the end of the year. Reactive Spring (1h) Spring Framework 5.0 has been released - and it now supports reactive applications in the Spring ecosystem. During this presentation, we'll talk about the reactive foundations of Spring Framework with the Reactor project and the reactive streams specification. We'll al...

  17. Framework Spring MVC

    OpenAIRE

    Jindráček, Petr

    2011-01-01

    The topic of this bachelor thesis is the web application framework Spring MVC which is an integral part of the Spring platform. That means it offers many options of adjustment and support of other significant technologies. The aim is to introduce basic principles of this framework on a theoretical level and subsequently examine them on a real example of application. The thesis is divided into three main parts. The first part is focused on Spring framework in general to introduce basic princip...

  18. Spring integration essentials

    CERN Document Server

    Pandey, Chandan

    2015-01-01

    This book is intended for developers who are either already involved with enterprise integration or planning to venture into the domain. Basic knowledge of Java and Spring is expected. For newer users, this book can be used to understand an integration scenario, what the challenges are, and how Spring Integration can be used to solve it. Prior experience of Spring Integration is not expected as this book will walk you through all the code examples.

  19. Pro Spring Integration

    CERN Document Server

    Lui, M; Chan, Andy; Long, Josh

    2011-01-01

    Pro Spring Integration is an authoritative book from the experts that guides you through the vast world of enterprise application integration (EAI) and application of the Spring Integration framework towards solving integration problems. The book is:. * An introduction to the concepts of enterprise application integration * A reference on building event-driven applications using Spring Integration * A guide to solving common integration problems using Spring Integration What makes this book unique is its coverage of contemporary technologies and real-world information, with a focus on common p

  20. Spring A Developer's Notebook

    CERN Document Server

    Tate, Bruce A

    2009-01-01

    This no-nonsense book quickly gets you up to speed on the new Spring open source framework. Favoring examples and practical application over theory, Spring: A Developer's Notebook features 10 code-intensive labs that'll reveal the many assets of this revolutionary, lightweight architecture. In the end, you'll understand how to produce simple, clean, and effective applications.

  1. Mockito for Spring

    CERN Document Server

    Acharya, Sujoy

    2015-01-01

    If you are an application developer with some experience in software testing and want to learn more about testing frameworks, then this technology and book is for you. Mockito for Spring will be perfect as your next step towards becoming a competent software tester with Spring and Mockito.

  2. Masters of the springs

    DEFF Research Database (Denmark)

    Laursen, Steffen

    2010-01-01

    flanked by villages that relied on these water recourses for agricultural production. The springs emerged in the zone separating the cemeteries from the settlements. The freshwater springs were actively incorporated into the religious landscape of the dead, by consistently erecting mounds of a particular...

  3. Comparison of the performance of experienced and novice surgeons: measurement of gripping force during laparoscopic surgery performed on pigs using forceps with pressure sensors.

    Science.gov (United States)

    Araki, Azumi; Makiyama, Kazuhide; Yamanaka, Hiroyuki; Ueno, Daiki; Osaka, Kimito; Nagasaka, Manabu; Yamada, Takahiro; Yao, Masahiro

    2017-04-01

    Laparoscopic surgical techniques are difficult to learn, and developing such skills involves a steep learning curve. To ensure surgeons achieve a high skill level, it is important to be able to measure and assess their skills. Therefore, it is necessary to understand the performance differences between experienced and novice surgeons, as such information could be used to help surgeons learn laparoscopic skills. We examined the differences in gripping and reaction force between experienced and novice surgeons during laparoscopic surgery. We measured the gripping force generated during laparoscopic surgery performed on pigs using forceps with pressure sensors. Several sensors, including strain gauges, accelerometers, and a potentiometer, were attached to the forceps. This study included 4 experienced and 4 novice surgeons. Each subject was asked to elevate the kidney in order to approach the renal hilus using the forceps. Throughout the experiment, we measured the gripping force and reaction force generated during the movement of the forceps in real time. The experienced and novice surgeons exhibited similar reaction force levels. Conversely, gripping force differed significantly between the groups. The experienced and novice surgeons exhibited mean gripping force levels of 3.06 and 7.15 N, respectively. The gripping force standard deviation values for the experienced and novice surgeons were 1.43 and 3.54 N, respectively. The mean and standard deviation gripping force values of the experienced surgeons were significantly lower than those of the novice surgeons (P = 0.015 and P = 0.011, respectively). This study indicated that experienced surgeons generate weaker but more stable gripping force than novice surgeons during laparoscopic procedures.

  4. Definition of Metrics to Evaluate Cochlear Array Insertion Forces Performed with Forceps, Insertion Tool, or Motorized Tool in Temporal Bone Specimens

    Directory of Open Access Journals (Sweden)

    Yann Nguyen

    2014-01-01

    Full Text Available Introduction. In order to achieve a minimal trauma to the inner ear structures during array insertion, it would be suitable to control insertion forces. The aim of this work was to compare the insertion forces of an array insertion into anatomical specimens with three different insertion techniques: with forceps, with a commercial tool, and with a motorized tool. Materials and Methods. Temporal bones have been mounted on a 6-axis force sensor to record insertion forces. Each temporal bone has been inserted, with a lateral wall electrode array, in random order, with each of the 3 techniques. Results. Forceps manual and commercial tool insertions generated multiple jerks during whole length insertion related to fits and starts. On the contrary, insertion force with the motorized tool only rose at the end of the insertion. Overall force momentum was 1.16 ± 0.505 N (mean ± SD, n=10, 1.337 ± 0.408 N (n=8, and 1.573 ± 0.764 N (n=8 for manual insertion with forceps and commercial and motorized tools, respectively. Conclusion. Considering force momentum, no difference between the three techniques was observed. Nevertheless, a more predictable force profile could be observed with the motorized tool with a smoother rise of insertion forces.

  5. VII International Congress of Engineering Physics

    Science.gov (United States)

    2015-01-01

    In the frame of the fortieth anniversary celebration of the Universidad Autónoma Metropolitana and the Physics Engineering career, the Division of Basic Science and Engineering and its Departments organized the "VII International Congress of Physics Engineering". The Congress was held from 24 to 28 November 2014 in Mexico City, Mexico. This congress is the first of its type in Latin America, and because of its international character, it gathers experts on physics engineering from Mexico and all over the globe. Since 1999, this event has shown research, articles, projects, technological developments and vanguard scientists. These activities aim to spread, promote, and share the knowledge of Physics Engineering. The topics of the Congress were: • Renewable energies engineering • Materials technology • Nanotechnology • Medical physics • Educational physics engineering • Nuclear engineering • High precision instrumentation • Atmospheric physics • Optical engineering • Physics history • Acoustics This event integrates lectures on top trending topics with pre-congress workshops, which are given by recognized scientists with an outstanding academic record. The lectures and workshops allow the exchange of experiences, and create and strengthen research networks. The Congress also encourages professional mobility among all universities and research centres from all countries. CIIF2014 Organizing and Editorial Committee Dr. Ernesto Rodrigo Vázquez Cerón Universidad Autónoma Metropolitana - Azcapotzalco ervc@correo.azc.uam.mx Dr. Luis Enrique Noreña Franco Universidad Autónoma Metropolitana - Azcapotzalco lnf@correo.azc.uam.mx Dr. Alberto Rubio Ponce Universidad Autónoma Metropolitana - Azcapotzalco arp@correo.azc.uam.mx Dr. Óscar Olvera Neria Universidad Autónoma Metropolitana - Azcapotzalco oon@correo.azc.uam.mx Professor Jaime Granados Samaniego Universidad Autónoma Metropolitana - Azcapotzalco jgs@correo.azc.uam.mx Dr. Roberto Tito Hern

  6. Newly diagnosed congenital factor VII deficiency and utilization of recombinant activated factor VII (NovoSeven®

    Directory of Open Access Journals (Sweden)

    Bartosh NS

    2013-03-01

    Full Text Available Nicole S Bartosh, Tara Tomlin, Christian Cable, Kathleen HalkaDepartment of Internal Medicine, Division of Medical Oncology, Scott and White Healthcare and Texas A and M Health Science Center College of Medicine, Temple, TX, USAAbstract: This case report presents a newly diagnosed congenital factor VII deficiency treated with recombinant activated factor VII (rFVIIa. Congenital factor VII deficiency is a rare autosomal-recessive bleeding disorder that occurs in fewer than 1/500,000 persons. Its presentation can vary from epistaxis to hemarthroses and severe central nervous system bleeding, and correlates poorly with factor VII levels. Our patient had not had a significant hemostatic challenge prior to his presentation and therefore never had any symptomatology suggestive of this disease. He was treated with rFVIIa, and was able to undergo repair of his fractures without bleeding.Case report: A 19-year-old African-American male presented to the emergency room after an altercation that resulted in significant trauma. He sustained bilateral mandibular angle fractures and orbital floor fractures, requiring urgent surgical correction. On initial evaluation, he was noted to have a prolonged prothrombin time of 40.1 seconds, with an International Normalized Ratio of 4.0, a normal activated partial thromboplastin time of 29.9 seconds, and a platelet count of 241. After receiving vitamin K and fresh frozen plasma, he was taken to the operating room for a temporary rigid maxillomandibular fixation. A 1:1 mixing study with normal plasma corrected the prothrombin time (decreasing from 40.7 to 14.7 seconds and a factor VII assay revealed 5% of the normal factor VII level. The patient was diagnosed with congenital factor VII deficiency. Due to his coagulopathy and the extensive surgical correction needed, rFVIIa was administered and surgery was accomplished without hemorrhagic sequelae.Conclusion: This case report and review describes a rare congenital

  7. Stark broadening parameter tables for O VII and Mg XI

    Directory of Open Access Journals (Sweden)

    Dimitrijević M.S.

    1998-01-01

    Full Text Available By using the semiclassical-perturbation formalism, we have calculated electron-, proton-, and He III-impact line widths and shifts for 14 O VII multiplets and 18 Mg XI multiplets, of importance for research, diagnostic and modeling of various astrophysical, laser produced, fusion and laboratory plasmas. For O VII calculations were performed for temperature range from 100,000 K to 2,000,000 K. and perturber densities (1017cm−3 - 1023cm−3. For Mg XI calculations were performed for temperature range from 500,000 K to 5,000,000 K. and perturber densities 1018cm−3 - 1024cm−3.

  8. The lupus band: do the autoantibodies target collagen VII?

    Science.gov (United States)

    Alahlafi, A M; Wordsworth, P; Wojnarowska, F

    2004-03-01

    Circulating autoantibodies directed against basement membrane zone (BMZ) components from patients with bullous pemphigoid and epidermolysis bullosa acquisita have been used to identify their target antigen in the skin and to confirm pathogenicity. Although the pattern of immunofluorescence in those diseases is similar to the lupus band, little is known about the origin and pathogenesis of the lupus band. Identifying the binding sites of the lupus band could provide a clue to the nature of the autoantigen that stimulates autoantibody formation in the skin of patients with systemic lupus erythematosus (SLE) and might provide valuable insight into the factors that influence the localization and pathogenicity of the lupus band. To investigate the relation between the lupus band and the main BMZ components and to identify the target epitopes of autoantibodies deposited in the skin of patients with SLE. Colocalization of the main components of the skin BMZ in nonlesional SLE skin with the lupus band was investigated using conventional immunofluorescence and confocal laser scanning microscopy. The effect of collagenase and pepsin on the expression of the lupus band was correlated with the differential sensitivity of these proteases on the collagenous and noncollagenous (NC) domains of collagen VII. Reactivity of sera from patients with SLE to a complete recombinant human NC1 domain of type VII collagen was then investigated by enzyme-linked immunosorbent assay (ELISA). Near complete colocalization of the lupus band with collagen VII was found in this study, and chemical degradation of the skin attenuated the expression of the lupus band. Collectively, the NC1 domain of collagen VII was suggested as the target antigen of the lupus band, but none of the sera from patients with SLE reacted with recombinant NC1 domain-coated ELISA plates. Alternative explanations for the results of the colocalization of the lupus band with collagen VII are discussed. The lupus band

  9. Learning Spring application development

    CERN Document Server

    Soni, Ravi Kant

    2015-01-01

    This book is intended for those who are interested in learning the core features of the Spring Framework. Prior knowledge of Java programming and web development concepts with basic XML knowledge is expected.

  10. Spring Bottom Trawl Survey

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The standardized NEFSC Spring Bottom Trawl Survey was initiated in 1968 and covered an area from Cape Hatteras, NC, to Nova Scotia, Canada, at depths >27m....

  11. The Springs at Pipe Spring National Monument, Arizona (pisp_springs)

    Data.gov (United States)

    National Park Service, Department of the Interior — This is an Arc/Info coverage consisting of 5 points representing the springs, natural and man-made, at Pipe Spring National Monument, Arizona. The springs were...

  12. Kasuperest viidi viis last ja algatati kriminaalmenetlus piinamises / Rasmus Rekand

    Index Scriptorium Estoniae

    Rekand, Rasmus

    2011-01-01

    Lugu asenduskodu teenust pakkuvast perekonnast, kelle hoole all oli lisaks pere enda 3 lapsele 6 võõrast last ning kuidas lastega mittehakkama saamine viis olukorrani, kus lapsed viidi kasupere juurest ära ja lisaks algatati uurimine keelatud võtete kasutamise kohta kasvatamistegevuses

  13. Viis armastuslugu suurel ekraanil / Tristan Priimägi

    Index Scriptorium Estoniae

    Priimägi, Tristan, 1976-

    2008-01-01

    Viis näidet filmiajaloost, kus režissööri ja staari vahel on tunded : Roger Vadim ja Tema Naised, Werner Herzog ja Klaus Kinski, Federico Fellini ja Anita Ekberg, Quentin Tarantino ja Uma Thurman, Rainer Werner Fassbinder ja Mr/Mrs X

  14. Recombinant-activated factor VII in the paediatric cardiac surgery ...

    African Journals Online (AJOL)

    V Agarwal, KE Okonta, PS Lal. Abstract. Background: The control of excessive bleeding after paediatric cardiac surgery can be challenging. This may make the use of recombinant-activated factor VII (rFVIIa) in preventing this excessive bleeding, after adopted conventional methods have failed, desirable. Our aim is to ...

  15. In silico dissection of Type VII Secretion System components across ...

    Indian Academy of Sciences (India)

    Type VII Secretion System (T7SS) is one of the factors involved in virulence of Mycobacteriun tuberculosis H37Rv. Numerous research efforts have been made in the last decade towards characterizing the components of this secretion system. An extensive genome-wide analysis through compilation of isolated information ...

  16. Viis aastakümmet raamatukogunduse radadel / Anne Veinberg

    Index Scriptorium Estoniae

    Veinberg, Anne

    2008-01-01

    Arvustus: Kikas, Konrad. Verba volant, scripta manent : viis aastakümmet raamatukogunduse ja infoteaduse radadel = Verba volant, scripta manent : five decades on the field of librarianship and information science. - Tallinn : Tallinna Tehnikaülikooli Kirjastus, 2008. - 366 lk. : ill. portr. - (Tallinna Tehnikaülikooli Raamatukogu töid. A ; 5)

  17. Photosynthetic pigments of oceanic Chlorophyta belonging to prasinophytes clade VII.

    Science.gov (United States)

    Lopes Dos Santos, Adriana; Gourvil, Priscillia; Rodríguez, Francisco; Garrido, José Luis; Vaulot, Daniel

    2016-02-01

    The ecological importance and diversity of pico/nanoplanktonic algae remains poorly studied in marine waters, in part because many are tiny and without distinctive morphological features. Amongst green algae, Mamiellophyceae such as Micromonas or Bathycoccus are dominant in coastal waters while prasinophytes clade VII, yet not formerly described, appear to be major players in open oceanic waters. The pigment composition of 14 strains representative of different subclades of clade VII was analyzed using a method that improves the separation of loroxanthin and neoxanthin. All the prasinophytes clade VII analyzed here showed a pigment composition similar to that previously reported for RCC287 corresponding to pigment group prasino-2A. However, we detected in addition astaxanthin for which it is the first report in prasinophytes. Among the strains analyzed, the pigment signature is qualitatively similar within subclades A and B. By contrast, RCC3402 from subclade C (Picocystis) lacks loroxanthin, astaxanthin, and antheraxanthin but contains alloxanthin, diatoxanthin, and monadoxanthin that are usually found in diatoms or cryptophytes. For subclades A and B, loroxanthin was lowest at highest light irradiance suggesting a light-harvesting role of this pigment in clade VII as in Tetraselmis. © 2015 Phycological Society of America.

  18. Walking with springs

    Science.gov (United States)

    Sugar, Thomas G.; Hollander, Kevin W.; Hitt, Joseph K.

    2011-04-01

    Developing bionic ankles poses great challenges due to the large moment, power, and energy that are required at the ankle. Researchers have added springs in series with a motor to reduce the peak power and energy requirements of a robotic ankle. We developed a "robotic tendon" that reduces the peak power by altering the required motor speed. By changing the required speed, the spring acts as a "load variable transmission." If a simple motor/gearbox solution is used, one walking step would require 38.8J and a peak motor power of 257 W. Using an optimized robotic tendon, the energy required is 21.2 J and the peak motor power is reduced to 96.6 W. We show that adding a passive spring in parallel with the robotic tendon reduces peak loads but the power and energy increase. Adding a passive spring in series with the robotic tendon reduces the energy requirements. We have built a prosthetic ankle SPARKy, Spring Ankle with Regenerative Kinetics, that allows a user to walk forwards, backwards, ascend and descend stairs, walk up and down slopes as well as jog.

  19. Plasma factor VII-activating protease is increased by oral contraceptives and induces factor VII activation in-vivo

    DEFF Research Database (Denmark)

    Sidelmann, Johannes J; Skouby, Sven O; Kluft, Cornelis

    2011-01-01

    Oral contraceptive (OC) use influences the hemostatic system significantly and is a risk factor for development of cardiovascular disease. Factor VII-activating protease (FSAP) has potential effects on hemostasis. The 1601GA genotype of the 1601G/A polymorphism in the FSAP gene expresses a FSAP...

  20. Damper Spring For Omega Seal

    Science.gov (United States)

    Maclaughlin, Scott T.; Montgomery, Stuart K.

    1993-01-01

    Damper spring reduces deflections of omega-cross-section seal, reducing probability of failure and extending life of seal. Spring is split ring with U-shaped cross section. Placed inside omega seal and inserted with seal into seal cavity. As omega seal compressed into cavity, spring and seal make contact near convolution of seal, and spring becomes compressed also. During operation, when seal dynamically loaded, spring limits deflection of seal, reducing stress on seal.

  1. The PrePex device is unlikely to achieve cost-savings compared to the forceps-guided method in male circumcision programs in sub-Saharan Africa.

    Directory of Open Access Journals (Sweden)

    Walter Obiero

    Full Text Available Male circumcision (MC reduces the risk of heterosexual HIV acquisition in men by approximately 60%. MC programs for HIV prevention are currently being scaled-up in fourteen countries in sub-Saharan Africa. The current standard surgical technique for MC in many sub-Saharan African countries is the forceps-guided male circumcision (FGMC method. The PrePex male circumcision (PMC method could replace FGMC and potentially reduce MC programming costs. We compared the potential costs of introducing the PrePex device into MC programming to the cost of the forceps-guided method.Data were obtained from the Nyanza Reproductive Health Society (NRHS, an MC service delivery organization in Kenya, and from the Kenya Ministry of Health. Analyses are based on 48,265 MC procedures performed in four Districts in western Kenya from 2009 through 2011. Data were entered into the WHO/UNAIDS Decision Makers Program Planning Tool. The tool assesses direct and indirect costs of MC programming. Various sensitivity analyses were performed. Costs were discounted at an annual rate of 6% and are presented in United States Dollars.Not including the costs of the PrePex device or referral costs for men with phimosis/tight foreskin, the costs of one MC surgery were $44.54-$49.02 and $54.52-$55.29 for PMC and FGMC, respectively.The PrePex device is unlikely to result in significant cost-savings in comparison to the forceps-guided method. MC programmers should target other aspects of the male circumcision minimum package for improved cost efficiency.

  2. Spring of women?

    Directory of Open Access Journals (Sweden)

    Mónica Castillo

    2012-12-01

    Full Text Available Terms such as “Islamic feminism” and “women’s movement” refer to those social movements of women that seek to assert their rights in Islamic societies. This brief study focuses on theses social movements of women and will presentan overview of the role and participation of women in the Arab Spring by examining news, events, press articles and opinions in order to contextualize the participation of women and feminists in the Arab Spring from a perspective of the social networking phenomenon as apparent drivers of the revolution.

  3. Pro Spring security

    CERN Document Server

    Scarioni, Carlo

    2013-01-01

    Security is a key element in the development of any non-trivial application. The Spring Security Framework provides a comprehensive set of functionalities to implement industry-standard authentication and authorization mechanisms for Java applications. Pro Spring Security will be a reference and advanced tutorial that will do the following: Guides you through the implementation of the security features for a Java web application by presenting consistent examples built from the ground-up. Demonstrates the different authentication and authorization methods to secure enterprise-level applications

  4. Instant Spring security starter

    CERN Document Server

    Jagielski, Piotr

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. A concise guide written in an easy-to-follow format following the Starter guide approach.This book is for people who have not used Spring Security before and want to learn how to use it effectively in a short amount of time. It is assumed that readers know both Java and HTTP protocol at the level of basic web programming. The reader should also be familiar with Inversion-of-Control/Dependency Injection, preferably with the Spring framework itsel

  5. A Quadratic Spring Equation

    Science.gov (United States)

    Fay, Temple H.

    2010-01-01

    Through numerical investigations, we study examples of the forced quadratic spring equation [image omitted]. By performing trial-and-error numerical experiments, we demonstrate the existence of stability boundaries in the phase plane indicating initial conditions yielding bounded solutions, investigate the resonance boundary in the [omega]…

  6. Editors' Spring Picks

    Science.gov (United States)

    Library Journal, 2011

    2011-01-01

    While they do not represent the rainbow of reading tastes American public libraries accommodate, Book Review editors are a wildly eclectic bunch. One look at their bedside tables and ereaders would reveal very little crossover. This article highlights an eclectic array of spring offerings ranging from print books to an audiobook to ebook apps. It…

  7. Spring batch essentials

    CERN Document Server

    Rao, P Raja Malleswara

    2015-01-01

    If you are a Java developer with basic knowledge of Spring and some experience in the development of enterprise applications, and want to learn about batch application development in detail, then this book is ideal for you. This book will be perfect as your next step towards building simple yet powerful batch applications on a Java-based platform.

  8. Energy Matters - Spring 2002

    Energy Technology Data Exchange (ETDEWEB)

    None

    2002-03-01

    Quarterly newsletter from DOE's Industrial Technologies Program to promote the use of energy-efficient industrial systems. The focus of the Spring 2002 Issue of Energy Matters focuses on premium energy efficiency systems, with articles on new gas technologies, steam efficiency, the Augusta Newsprint Showcase, and more.

  9. Springing of ships waves

    NARCIS (Netherlands)

    Van Gunsteren, F.F.

    1978-01-01

    This thesis is the result of an investigation of the assumptions underlying the general applied method for the calculation of springing of ships in waves, which has been proposed by the author some decade ago. It has been found that, contrary to the general practice in seakeeping research, the

  10. Mangostanaxanthone VII, a new cytotoxic xanthone from Garcinia mangostana.

    Science.gov (United States)

    Ibrahim, Sabrin R M; Mohamed, Gamal A; Elfaky, Mahmoud A; Zayed, Mohamed F; El-Kholy, Amal A; Abdelmageed, Osama H; Ross, Samir A

    2017-11-08

    Garcinia mangostana L. (the queen of fruits, mangosteen, family Guttiferae) is a wealthy source of xanthones. The CHCl3 soluble fraction of the air-dried pericarps of G. mangostana provided a new xanthone: mangostanaxanthone VII (5), along with four known xanthones: mangostanaxanthones I (1) and II (2), gartanin (3) and γ-mangostin (4). The structural verification of these metabolites was achieved by different spectral techniques, including UV, IR, 1D and 2D NMR and HRESIMS. The new metabolite was assessed for cytotoxic potential, using sulforhodamine B (SRB) assay towards the A549 and MCF-7 cancer cell lines. Moreover, its antimicrobial effects were evaluated against various bacterial and fungal strains, using agar disc diffusion assay. Mangostanaxanthone VII showed moderate cytotoxic activity against the A549 and MCF7 cell lines with IC50s 26.1 and 34.8 μM, respectively, compared with doxorubicin (0.74 and 0.41 μM, respectively).

  11. Association of factor VII protein concentration with lifestyle factors

    DEFF Research Database (Denmark)

    Bladbjerg, E-M; Møller, L; Jespersen, J

    1998-01-01

    Several studies have demonstrated that changes in fasting levels of factor VII coagulant activity (FVII:C), a thrombotic risk marker, are due to changes in FVII protein concentrations (FVII:Ag). Consequently, studies on FVII now often include measurements of FVII:Ag. The present cross-sectional s......Several studies have demonstrated that changes in fasting levels of factor VII coagulant activity (FVII:C), a thrombotic risk marker, are due to changes in FVII protein concentrations (FVII:Ag). Consequently, studies on FVII now often include measurements of FVII:Ag. The present cross....... These results suggest that blood lipids are major determinants of FVII:Ag, but that other lifestyle factors such as insulin, BMI and physical activity can also influence FVII:Ag. Furthermore, the association between FVII:Ag and bleeding time suggests an effect of FVII or the FVII pathway on primary haemostasis...

  12. Vena porta thrombosis in patient with inherited factor VII deficiency

    DEFF Research Database (Denmark)

    Klovaite, Jolanta; Friis-Hansen, Lennart Jan; Larsen, Fin S

    2010-01-01

    Most clotting factor VII (FVII)-deficient patients suffer from bleeding episodes and occasionally thromboembolic complications after surgical interventions or replacement therapy. However, thromboses without apparent triggering factors may occur as well. We report a case of a pregnant woman...... vein with well expressed portosystemic collaterals, heterozygosity for three common polymorphisms in FVII gene, associated with reduction in plasma FVII levels, and no other factors predisposing to thrombosis....

  13. Fish Springs molluscan studies: House and Percy Springs

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report summarizes the findings of a limited survey of House and Percy Springs molluscan fauna within Fish Springs National Wildlife Refuge. Various...

  14. CROSS SECTION EVALUATIONS FOR ENDF/B-VII.

    Energy Technology Data Exchange (ETDEWEB)

    HERMAN, M.; ROCHMAN, D.; OBLOZINSKY, P.

    2006-06-05

    This is the final report of the work performed under the LANL contract on neutron cross section evaluations for ENDF/B-VII (April 2005-May 2006). The purpose of the contract was to ensure seamless integration of the LANL neutron cross section evaluations in the new ENDF/B-VII library. The following work was performed: (1) LANL evaluated data files submitted for inclusion in ENDF/B-VII were checked and, when necessary, formal formatting errors were corrected. As a consequence, ENDF checking codes, run on all LANL files, do not report any errors that would rise concern. (2) LANL dosimetry evaluations for {sup 191}Ir and {sup 193}Ir were completed to match ENDF requirements for the general purpose library suitable for transport calculations. A set of covariances for both isotopes is included in the ENDF files. (3) Library of fission products was assembled and successfully tested with ENDF checking codes, processed with NJOY-99.125 and simple MCNP calculations. (4) KALMAN code has been integrated with the EMPIRE system to allow estimation of covariances based on the combination of measurements and model calculations. Covariances were produced for 155,157-Gd and also for 6 remaining isotopes of Gd.

  15. Evaluation of novel slim biopsy forceps for diagnosis of biliary strictures: Single-institutional study of consecutive 360 cases (with video).

    Science.gov (United States)

    Yamamoto, Kenjiro; Tsuchiya, Takayoshi; Itoi, Takao; Tsuji, Shujiro; Tanaka, Reina; Tonozuka, Ryosuke; Honjo, Mitsuyoshi; Mukai, Shuntaro; Kamada, Kentaro; Fujita, Mitsuru; Asai, Yasutsugu; Matsunami, Yukitoshi; Nagakawa, Yuichi; Yamaguchi, Hiroshi; Sofuni, Atsushi

    2017-09-21

    To evaluate the feasibility and reliability of endoscopic transpapillary bile duct biopsy for the diagnosis of biliary strictures. A total of 360 patients (241 men) who underwent endoscopic retrograde cholangiopancreatography for biliary strictures with biopsy from April 2012 to March 2016 at Tokyo Medical University Hospital were retrospectively reviewed. This study was approved by our Institutional Review Board (No. 3516). Informed consent was obtained from all individual participants included in this study. The biopsy specimens were obtained using a novel slim biopsy forceps (Radial Jaw 4P, Boston Scientific, Boston, MA, United States). The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 69.6%, 100%, 100%, 59.1%, and 78.8%, respectively. The sensitivity was 75.6% in bile duct cancer, 64% in pancreatic cancer, 61.1% in gallbladder cancer, and 57.1% in metastasis. In bile duct cancer, a lower sensitivity was observed for perihilar bile duct stricture (68.7%) than for distal bile duct stricture (83.1%). In terms of the stricture lengths of pancreatic cancer, gallbladder cancer, and metastasis, a longer stenosis resulted in a better sensitivity. In particular, there was a significant difference between pancreatic cancer and gallbladder cancer (P < 0.05). One major complication was perforation of the extrahepatic bile duct with bile leakage. Endoscopic transpapillary biopsy alone using novel slim biopsy forceps is feasible and reliable, but restrictive. Biopsy should be performed in consideration of the stricture level, stricture length, and cancer type.

  16. Fecundity of the spider crab Mithraculus forceps (Decapoda, Mithracidae from the northeastern coast of the state of São Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Valter J. Cobo

    2008-03-01

    Full Text Available Fecundity is one of the most important parameters in studying the reproductive output of Pleocyemata decapods, especially because of its relationship to the efficiency of population replacement. Knowledge of fecundity provides basic elements for understanding the reproductive strategies, dynamics, and evolution of a given population. The present investigation provides informations on fecundity, egg size, egg loss, and the relationship between fecundity and selected environmental features, for the spider crab Mithraculus forceps (A. Milne Edwards, 1875. Ovigerous crabs were collected each month during 2000, by SCUBA diving, at Couves Island (23º25'25"S, 44º52'03"W on the northeastern coast of the state of São Paulo, Brazil. A total of 40 ovigerous females with egg in early development (initial stage and 28 final stage eggs were obtained and analyzed. Mean fecundity, from eggs of the initial stage, was 402.8 ± 240.1 eggs, ranging from 60 to 1,123 eggs. Sizes of females ranged from 9.4 to 14.0 mm carapace width. Mean egg size was 0.56 ± 0.06 mm diameter. A 20.33% rate of egg loss was estimated by comparing the fecundities of batches of eggs in early and late development (40 initial batches and 28 final stages batches. There were no significant relationships between the water temperature or salinity and variations in fecundity. As in most brachyuran species, M. forceps showed a strong conservative relationship between fecundity and body size.

  17. Leaf spring, and electromagnetic actuator provided with a leaf spring

    NARCIS (Netherlands)

    Berkhoff, Arthur P.; Lemmen, Remco Louis Christiaan

    2002-01-01

    The invention relates to a leaf spring for an electromagnetic actuator and to such an electromagnetic actuator. The leaf spring is formed as a whole from a disc of plate-shaped, resilient material. The leaf spring comprises a central fastening part, an outer fastening part extending therearound and

  18. Studying Springs in Series Using a Single Spring

    Science.gov (United States)

    Serna, Juan D.; Joshi, Amitabh

    2011-01-01

    Springs are used for a wide range of applications in physics and engineering. Possibly, one of their most common uses is to study the nature of restoring forces in oscillatory systems. While experiments that verify Hooke's law using springs are abundant in the physics literature, those that explore the combination of several springs together are…

  19. Spring magnet films.

    Energy Technology Data Exchange (ETDEWEB)

    Bader, S. D.; Fullerton, E. E.; Gornakov, V. S.; Inomata, A.; Jiang, J. S.; Nikitenko, V. I.; Shapiro, A. J.; Shull, R. D.; Sowers, C. H.

    1999-03-29

    The properties of exchange-spring-coupled bilayer and superlattice films are highlighted for Sm-Co hard magnet and Fe or Co soft magnet layers. The hexagonal Sm-Co is grown via magnetron sputtering in a- and b-axis epitaxial orientations. In both cases the c-axis, in the film plane, is the easy axis of magnetization. Trends in coercivity with film thickness are established and related to the respective microstructure of the two orientations. The magnetization reversal process for the bilayers is examined by magnetometry and magneto-optical imaging, as well as by simulations that utilize a one-dimensional model to provide the spin configuration for each atomic layer. The Fe magnetization is pinned to that of the Sm-Co at the interface, and reversal proceeds via a progressive twisting of the Fe magnetization. The Fe demagnetization curves are reversible as expected for a spring magnet. Comparison of experiment and simulations indicates that the spring magnet behavior can be understood from the intrinsic properties of the hard and soft layers. Estimated are made of the ultimate gain in performance that can potentially be realized in this system.

  20. The role of Title VII funding in academic general pediatrics fellowships and leadership.

    Science.gov (United States)

    DeWitt, Thomas G; Cheng, Tina L

    2008-11-01

    Since 1979, the Health Resources and Services Administration, Bureau of Health Professionals Title VII, Section 747 (Title VII) programs have been critical to both fellowship and leadership training in academic general pediatrics. Title VII-funded faculty development programs and targeted contract funding have played an important role in training pediatric academic generalist faculty, supporting individual fellowship programs, defining the core elements of such programs, and expanding faculty development to include leadership training. As the major continuing source of external funding for these programs, Title VII has produced documented successful outcomes in all areas in terms of both numbers and accomplishments of trainees. Title VII-funded fellows, as well as the leaders trained, have formed and extended the field of general pediatrics, ultimately improving the health of children, especially in underserved and vulnerable populations.This article is part of a theme issue of Academic Medicine on the Title VII health professions training programs.

  1. Anticancer Activity of the Antimicrobial Peptide Scolopendrasin VII Derived from the Centipede, Scolopendra subspinipes mutilans.

    Science.gov (United States)

    Lee, Joon Ha; Kim, In-Woo; Kim, Sang-Hee; Kim, Mi-Ae; Yun, Eun-Young; Nam, Sung-Hee; Ahn, Mi-Young; Kang, Dongchul; Hwang, Jae Sam

    2015-08-01

    Previously, we performed de novo RNA sequencing of Scolopendra subspinipes mutilans using high-throughput sequencing technology and identified several antimicrobial peptide candidates. Among them, a cationic antimicrobial peptide, scolopendrasin VII, was selected based on its physicochemical properties, such as length, charge, and isoelectric point. Here, we assessed the anticancer activities of scolopendrasin VII against U937 and Jurkat leukemia cell lines. The results showed that scolopendrasin VII decreased the viability of the leukemia cells in MTS assays. Furthermore, flow cytometric analysis and acridine orange/ethidium bromide staining revealed that scolopendrasin VII induced necrosis in the leukemia cells. Scolopendrasin VII-induced necrosis was mediated by specific interaction with phosphatidylserine, which is enriched in the membrane of cancer cells. Taken together, these data indicated that scolopendrasin VII induced necrotic cell death in leukemia cells, probably through interaction with phosphatidylserine. The results provide a useful anticancer peptide candidate and an efficient strategy for new anticancer peptide development.

  2. Uudised : Baltimaade suurim, XII "Jazzkaar". VII rahvusvaheline koorifestival. Leipzigis improviseeriti edukalt

    Index Scriptorium Estoniae

    2001-01-01

    23.-29. apr. toimuvast festivalist "Jazzkaar 2001". VII rahvusvahelisest koorifestivalist "Tallinn "2001". 6. ja 7. apr. Leipzigis toimunud V rahvusvahelisest improvisatsioonikonkursist, kus osalesid ka eesti interpreedid

  3. Immune reactivity to type VII collagen: implications for gene therapy of recessive dystrophic epidermolysis bullosa.

    Science.gov (United States)

    Pendaries, V; Gasc, G; Titeux, M; Leroux, C; Vitezica, Z G; Mejía, J E; Décha, A; Loiseau, P; Bodemer, C; Prost-Squarcioni, C; Hovnanian, A

    2010-07-01

    Recessive dystrophic epidermolysis bullosa (RDEB) is a severe genodermatosis caused by loss-of-function mutations in COL7A1 encoding type VII collagen, the component of anchoring fibrils. As exogenous type VII collagen may elicit a deleterious immune response in RDEB patients during upcoming clinical trials of gene therapies or protein replacement therapies, we developed enzyme-linked immunosorbent assay (ELISA) and enzyme-linked immunosorbent spot (ELISPOT) assays to analyze B- and T-cell responses, to the full-length type VII collagen. The ELISA was highly sensitive and specific when tested against sera from 41 patients with epidermolysis bullosa acquisita (EBA), and the IFN-gamma ELISPOT detected a cellular response that correlated with ongoing EBA manifestations. Both tests were next applied to assess the risk of an immune response to type VII collagen in seven RDEB patients with a range of type VII collagen expression profiles. Immune responses against type VII collagen were dependent on the expression of type VII collagen protein, and consequently on the nature and position of the respective COL7A1 mutations. These immunologic tests will be helpful for the selection of RDEB patients for future clinical trials aiming at restoring type VII collagen expression, and in monitoring their immune response to type VII collagen after treatment.

  4. Lithium preferentially inhibits adenylyl cyclase V and VII isoforms.

    Science.gov (United States)

    Mann, Liad; Heldman, Eliahu; Shaltiel, Galit; Belmaker, R H; Agam, Galila

    2008-06-01

    Lithium ions' inhibition of adenylyl cyclase (AC) has not been previously studied for the newly discovered AC isoforms. COS7 cells were transfected with each of the nine membrane-bound AC isoforms cDNAs with or without D1- or D2-dopamine receptor cDNA. AC activity was measured as [3H]cAMP accumulation in cells pre-incubated with [3H]adenine followed by incubation with phosphodiesterase inhibitors together with either the D1 agonist SKF-82958 alone, or forskolin, in the presence or absence of the D2 agonist quinpirole. At 1 mm or 2 mm lithium inhibited only AC-V activity when the enzyme was stimulated by forskolin, a direct activator of AC. Lithium inhibited AC-V (by 50%), AC-VII (by 40%) and AC-II (by 25%) when stimulated via the D1 receptors, but did not affect the Ca2+-activated isoforms when stimulated by the Ca2+ ionophore A23187. Quinpirole inhibits AC via the Gi protein. Lithium did not affect quinpirole-inhibited FSK-activated AC-V activity nor did it affect superactivated AC-V or AC-I following the removal of quinpirole. The data suggest interference of lithium with transduction pathways mediated via AC-V or AC-VII; only the active conformation of these AC isoforms is inhibited by lithium; the inhibitory effect of lithium is abolished when the enzyme is superactivated. The marked inhibition of AC-V and AC-VII by lithium suggests that these two isoforms may be involved in mediating the mood-stabilizing effect of lithium.

  5. Abnormal deposition of type VII collagen in Kindler syndrome.

    Science.gov (United States)

    Wiebe, C B; Larjava, H S

    1999-01-01

    Kindler syndrome is an extremely rare genetic disorder with features of epidermolysis bullosa and poikiloderma congenitale. Approximately 70 cases have been documented in the past 50 years, but only a few investigations of the basement membrane components have been done on these patients. The aim of this study was to examine the components of the basement membrane zone in search of the pathobiological defect(s) responsible for the clinical findings from a female 16-year-old patient diagnosed with Kindler syndrome. This patient also suffered from advanced early-onset periodontal disease. Biopsies were taken from inflamed gingiva and noninflamed oral mucosa as part of periodontal treatment. The basement membrane zone was examined using immunofluorescence microscopy to bullous pemphigoid antigens 1 and 2, collagen types IV and VII, laminins-1 and -5, and integrins alpha3beta1 and alpha6beta4. The biopsies studied revealed blistering with trauma above the level of lamina densa based on distribution of type IV collagen and laminin-1 at the blister floor. In the noninflamed mucosa, discontinuous areas of the basement membrane zone were found. Expression of the basement membrane zone components and the integrins studied appeared otherwise normal with the exception of type VII collagen which was found in abnormal locations deep in the connective tissue stroma. Our results suggest that Kindler syndrome is associated with abnormalities in the construction of the basement membrane, especially in the expression of type VII collagen. These alterations are likely to play a role as etiological factors leading to blister formation and early onset periodontal disease.

  6. Pengembangan Vaksin Inaktif Tetelo Genotipe VII Isolat Lokal pada Kondisi Laboratorium. (DEVELOPMENT OF TETELO INACTIVATED VACCINE GENOTYPE VII LOCAL ISOLATE IN LABORATORY CONDITION

    Directory of Open Access Journals (Sweden)

    Risa Indriani

    2016-11-01

    Full Text Available Tetelo/Newcastle disease (ND inactive vaccine of genotipe VII virus local isolate have been developedin laboratory condition and compared with commercial ND vaccine. A total of 200 commercial layer chickenat 4 weeks age were divided into four groups, that were (1 vaccinated with ND genotype VII Indonesia/GTT/11, (2 vaccinated with commercial ND vaccine genotype VII, (3 vaccinated with commercial genotypeVI and (4 unvaccinated as control group. After two weeks post vaccination, 10 chicken from each groupwere sellected randomly and challenged with 105 EID50 per 0,1 mL of ND virus genotype VII Indonesian/GTT/11 by intramuscular. Chicken were observed, and swab were collected from oropharyngeal and cloacaat 2, 5, 7, 12 and 14 days post challenge. The result of this study showed inactived vaccine genotype VIIIndonesia/GTT/11 can induced a good antibody titer response to vaccinated chicken with mean titer 7.30log2 and CI 6.3 to 7.8, while commercial ND vaccine genotipe VII was 5.30 log2 with CI 3.8-6.7, andcommercial genotype VI was 4.8 log2 with CI 4.1-5.4. The level of protection which determined by noclinical signs, mortality and viral shedding showed 100% protection in chicken vaccinated with Indonesia/GTT/11 and commercial genotype VII were 100%, compared with control chicken, and vaccined commercialND vaccine genotype VII, compared with control chicken. While in chicken vaccinated commercial NDvaccine genotype VI showed viral shedding on day two post challenge, but there were no clinical sign andmortality. Based on this results, Indonesia/GTT/11 genotype VII ND vaccine could be used as an alternativeND vaccine to protect chicken from infection of ND virus genotype VII in the field.

  7. Imagining Ferdinand VII, a Catholic and felon King

    OpenAIRE

    Gregorio Alonso

    2015-01-01

    The public image of King Ferdinand VII (1784-1833) was built through a process of exaltation and sacralization as a result of the Napoleonic invasion of the Iberian Peninsula that started in the fall of 1807. This article tackles the mechanisms put in place in order to achieve such a target. It also unravels the ways in which wide sectors of the Catholic clergy collaborated in the identification of the King’s image with that of the Spanish nation in danger. The text also sheds light on the Am...

  8. Interleukin VII Receptor Gene Polymorphism in Multiple Sclerosis Patients

    Directory of Open Access Journals (Sweden)

    M Ahmadzadeh Raji

    2011-10-01

    Full Text Available Introduction: Multiple Sclerosis is a chronic disease of central nervous system. Disease is more common in young adults and females and causes neurologic symptoms and signs. Cytokine IL-7 is a 25– kDa glycoprotein that has an important role in Lymphopoiesis. Interleukin VII receptor gene has been identified to be associated with multiple sclerosis, so its assessment is important. Methods: We investigated 60 Iranian patients with clinically definite MS and 60 normal healthy controls with negative family history for MS. After blood sampling, DNA was extracted from the whole blood, then we used 2 sets of primers for promoter and exon 4 of IL-VII gene. These fragments were amplified by PCR technique and early screening was performed by SSCP technic in the presence of control samples. Then different patterns with control samples were sent for DNA sequencing. Results: We observed one SNP in promoter. Most of the alleles of the patients were homozygote. There were two 2 SNPs and two sequence variations in exon 4 as P.H165H and P.V138I, which has been submitted in European Bioinformatics Institute under the access number of FR863587. Conclusion: Further studies on control group will be required to reveal the effects of these SNPs on the ILVII-R α protein and they can probably be useed as a biomarker for early diagnosis of MS.

  9. Characterization of a Myosin VII MyTH/FERM domain

    Science.gov (United States)

    Moen, Rebecca J.; Johnsrud, Daniel O.; Thomas, David D.; Titus, Margaret A.

    2011-01-01

    A group of closely related myosins are characterized by the presence of at least one MyTH/FERM (myosin talin homology 4; band 4.1, ezrin, radixin, moesin) domain in their C-terminal tails. This domain interacts with a variety of binding partners, and mutations in either the MyTH4 or FERM domains of myosin VII and XV result in deafness, highlighting the functional importance of each domain. The N-terminal MyTH/FERM region of Dictyostelium myosin VII (M7) has been isolated as a first step toward gaining insight into the function of this domain and its interaction with binding partners. The M7 MyTH4/FERM domain (MF1) binds to both actin and microtubules in vitro, with dissociation constants of 13.7 and 1.7 μM, respectively. Gel filtration and UV spectroscopy reveal that MF1 exists as a monomer in solution and forms a well-folded, compact conformation with a high degree of secondary structure. These results indicate that MF1 forms an integrated structural domain that serves to couple actin filaments and microtubules in specific regions of the cytoskeleton. PMID:21875595

  10. Mucopolysaccharidosis type VII in a German Shepherd Dog.

    Science.gov (United States)

    Silverstein Dombrowski, Deborah C; Carmichael, K Paige; Wang, Ping; O'Malley, Thomas M; Haskins, Mark E; Giger, Urs

    2004-02-15

    A 12-week-old male German Shepherd Dog was evaluated because of a 3-week history of a progressive inability to ambulate. Clinical and laboratory findings included skeletal deformities, corneal cloudiness, cytoplasmic granules in the neutrophils and lymphocytes of blood and CSF and glycosaminoglycans in a urine sample (detected via a toluidine blue spot test). Enzyme activity and DNA analyses confirmed mucopolysaccharidosis type VII as a result of severe beta-glucuronidase deficiency; this condition had been identified in a mixed-breed dog (likely of German Shepherd Dog descent) that was reported 20 years earlier and caused by the same missense mutation. Because of the progressive nature of this disease, the puppy was euthanatized and all tissues examined contained evidence of lysosomal storage leading to marked cellular distention. Mucopolysaccharidosis type VII is only one of many hereditary lysosomal storage diseases identified in companion animals. It is important that clinicians recognize the typical signs of lysosomal storage diseases and are aware of the cytologic and urinary screening tests for mucopolysaccharidosis disorders. Furthermore, there are specific blood enzyme and DNA-based tests to distinguish the forms of mucopolysaccharidosis in affected and carrier animals.

  11. PENINGKATAN PEMAHAMAN KONSEP HIMPUNAN MELALUI MIND MAPPING KELAS VII SMP

    Directory of Open Access Journals (Sweden)

    Dewi Arfiyanti

    2017-06-01

    Full Text Available The kind of this research is classroom action reseach (CAS. This research was conducted to 34 student in the VII.D class of SMP. The aim of this research is to describe understanding concept of set through mind mapping. The data collected is the result of observation, mind mapping and finals tes of the cycle. There are six indicators to decide sub topic, keyword, color design, supporting data and material of sets in assessing mind mapping. The result of mind mapping shows that students can produce picture and write the keywords, Supporting data in the form of notation and Venn diagram. Students comprehended sets concept and finished contextual problem by using Venn diagram. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK. Penelitian ini dilaksanakan pada kelas VII. D SMP berjumlah 34 siswa. Tujuan penelitian ini adalah mendiskripsikan peningkatkan pemahaman konsep himpunan melalui mind mapping. Data yang dikumpulkan yaitu data observasi, hasil mind mapping dan tes akhir siklus. Penilaian mind mapping ada enam indikator yaitu menentukan sub topik, menentukan cabang sub topik, kata kunci, desain warna, data pendukung, dan materi himpunan. Berdasarkan hasil mind mapping menunjukkan siswa telah menghasilkan gambar dengan menuliskan kata kunci, data pendukung berupa notasi dan diagram Venn. Siswa memahami konsep himpunan dan menyelesaikan masalah kontekstual dengan diagram Venn.

  12. Imagining Ferdinand VII, a Catholic and felon King | Imaginando a Fernando VII, rey católico y felón

    National Research Council Canada - National Science Library

    Gregorio Alonso

    2015-01-01

    The public image of King Ferdinand VII (1784-1833) was built through a process of exaltation and sacralization as a result of the Napoleonic invasion of the Iberian Peninsula that started in the fall of 1807...

  13. Spring viremia of carp

    Science.gov (United States)

    Ahne, W.; Bjorklund, H.V.; Essbauer, S.; Fijan, N.; Kurath, G.; Winton, J.R.

    2002-01-01

    pring viremia of carp (SVC) is an important disease affecting cyprinids, mainly common carp Cyprinus carpio. The disease is widespread in European carp culture, where it causes significant morbidity and mortality. Designated a notifiable disease by the Office International des Epizooties, SVC is caused by a rhabdovirus, spring viremia of carp virus (SVCV). Affected fish show destruction of tissues in the kidney, spleen and liver, leading to hemorrhage, loss of water-salt balance and impairment of immune response. High mortality occurs at water temperatures of 10 to 17°C, typically in spring. At higher temperatures, infected carp develop humoral antibodies that can neutralize the spread of virus and such carp are protected against re-infection by solid immunity. The virus is shed mostly with the feces and urine of clinically infected fish and by carriers. Waterborne transmission is believed to be the primary route of infection, but bloodsucking parasites like leeches and the carp louse may serve as mechanical vectors of SVCV. The genome of SVCV is composed of a single molecule of linear, negative-sense, single-stranded RNA containing 5 genes in the order 3¹-NPMGL-5¹ coding for the viral nucleoprotein, phosphoprotein, matrix protein, glycoprotein, and polymerase, respectively. Polyacrylamide gel electrophoresis of the viral proteins, and sequence homologies between the genes and gene junctions of SVCV and vesicular stomatitis viruses, have led to the placement of the virus as a tentative member of the genus Vesiculovirus in the family Rhabdoviridae. These methods also revealed that SVCV is not related to fish rhabdoviruses of the genus Novirhabdovirus. In vitro replication of SVCV takes place in the cytoplasm of cultured cells of fish, bird and mammalian origin at temperatures of 4 to 31°C, with an optimum of about 20°C. Spring viremia of carp can be diagnosed by clinical signs, isolation of virus in cell culture and molecular methods. Antibodies directed

  14. Developing bulk exchange spring magnets

    Energy Technology Data Exchange (ETDEWEB)

    Mccall, Scott K.; Kuntz, Joshua D.

    2017-06-27

    A method of making a bulk exchange spring magnet by providing a magnetically soft material, providing a hard magnetic material, and producing a composite of said magnetically soft material and said hard magnetic material to make the bulk exchange spring magnet. The step of producing a composite of magnetically soft material and hard magnetic material is accomplished by electrophoretic deposition of the magnetically soft material and the hard magnetic material to make the bulk exchange spring magnet.

  15. Spring security 3.x cookbook

    CERN Document Server

    Mankale, Anjana

    2013-01-01

    This book follows a cookbook style exploring various security solutions provided by Spring Security for various vulnerabilities and threat scenarios that web applications may be exposed to at the authentication and session level layers.This book is for all Spring-based application developers as well as Java web developers who wish to implement robust security mechanisms into web application development using Spring Security.Readers are assumed to have a working knowledge of Java web application development, a basic understanding of the Spring framework, and some knowledge of the fundamentals o

  16. A Correlation Study of the Minnesota Teacher Attitude Inventory and Kerlinger's ES-VII.

    Science.gov (United States)

    Padgett, Harry G.

    The Minnesota Teacher Attitude Inventory (MTAI) and Kerlinger's ES-VII are instruments which examine both the individual's general educational philosophy and his ideas of practice. A study was designed to investigate (1) the common variance in the Difference score of the 150-item MTAI and the D score of Kerlinger's 30-item ES-VII with respect to…

  17. Aristóteles y las series causales infinitas en Física VII y VIII

    Directory of Open Access Journals (Sweden)

    Alberto Ross

    2013-11-01

    Full Text Available The aim of this paper is to show that we have at least two different arguments that prove the First Motor's existence. Even though there are coincidences between Physics VII 1 and VIII 5, their arguments are not identical. Physics VII argue the impossibility of an infinite movement in a finite time and VIII 5 the necessity of a "principal" cause.

  18. 20 CFR Appendix Vii to Subpart C... - “Old-Law” Contribution and Benefit Base

    Science.gov (United States)

    2010-04-01

    ... Appendix VII to Subpart C of Part 404 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Computing Primary Insurance Amounts Pt. 404, Subpt. C, App. VII... appendix IV). This is the contribution and benefit base that would have been effective under the Social...

  19. Underuse of Title VII Funding for Indian Education in Arizona, Nevada, and Utah

    Science.gov (United States)

    West Comprehensive Center at WestEd, 2015

    2015-01-01

    Title VII provides funding for the education of American Indian/Alaska Native students based on a formula grant available to school districts, charter schools, and local education agencies (LEAs). This report explores why some eligible schools and districts do not apply for federal Title VII, potentially resulting in American Indian/Alaska Native…

  20. 77 FR 5396 - Recordkeeping and Reporting Requirements Under Title VII, the ADA, and GINA

    Science.gov (United States)

    2012-02-03

    ... GINA protects job applicants, current and former employees, labor union members, and apprentices and... more employees, employment agencies, labor unions, and joint labor-management training programs, as... recordkeeping requirements under title VII of the Civil Rights Act of 1964 (Title VII) and the Americans with...

  1. Fatigue behaviour of technical springs

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, B.; Berger, C. [Institut fuer Werkstoffkunde und Staatliche Materialpruefungsanstalt Darmstadt, Technische Universitaet Darmstadt, Grafenstrasse 2, 64283 Darmstadt (Germany)

    2005-11-01

    Technical Springs belong to the components with the highest cyclic and superposed static load. Nevertheless they have to fulfill the requirements of lightweight constructions. This is only possible, if high strength materials with special properties are carefully manufactured to well designed springs and special additional treatments are carried out, which impose an advantageous residual stress profile in the surface layers of the springs. After a short historical view on the spring research activities in Professor Thums area, some aspects of the fatigue behaviour of hot formed parabolic leaf springs are presented. Then the fatigue properties of cold formed helical compression springs made of different steel spring wires are discussed. Finally some results on the fatigue behaviour of helical springs at a very high number of load cycles are reported. (Abstract Copyright [2005], Wiley Periodicals, Inc.) [German] Technische Federn gehoeren zu den am hoechsten zyklisch beanspruchten Bauteilen mit gleichzeitig hoher Vorspannung bzw. Mittelspannung. Trotzdem sollen sie den Forderungen des Leichtbaus genuegen. Realisierbar ist dies nur durch hochfeste Federwerkstoffe mit speziellen Eigenschaften, die sorgfaeltig zu ueberlegt konstruierten Federn verarbeitet werden, und wenn zusaetzliche Behandlungen durchgefuehrt werden, die einen guenstigen Eigenspannungszustand in der Federrandschicht erzeugen. Nach einem kurzen historischen Rueckblick auf die Forschungsaktivitaeten zur Zeit von August Thum wird zunaechst das Ermuedungsverhalten warm geformter Parabelfedern behandelt. Der folgende Abschnitt befasst sich mit den Schwingfestigkeitseigenschaften kalt geformter Schraubendruckfedern aus verschiedenen Federstahldraehten. Abschliessend wird ueber das Ermuedungsverhalten von Schraubenfedern bei sehr hohen Schwingspielzahlen berichtet. (Abstract Copyright [2005], Wiley Periodicals, Inc.)

  2. Experimenting with Inexpensive Plastic Springs

    Science.gov (United States)

    Perez, Leander; Marques, Adriana; Sánchez, Iván

    2014-01-01

    Acommon undergraduate laboratory experience is the determination of the elastic constant of a spring, whether studying the elongation under a static load or studying the damped harmonic motion of the spring with a suspended mass. An alternative approach to this laboratory experience has been suggested by Menezes et al., aimed at studying the…

  3. Coagulation factor VII, serum-triglycerides and the R/Q353 polymorphism: Differences between older men and women

    NARCIS (Netherlands)

    Mennen, L.I.; Maat, M.P.M. de; Schouten, E.G.; Kluft, C.; Jong, P.T.V.M. de; Hofman, A.; Grobbee, D.E.

    1997-01-01

    Coagulation factor VII activity (FVII:C) is a risk indicator for cardiovascular disease. It is related to serum-triglycerides and the R/Q353 polymorphism (alleles R and Q) in the gene coding for factor VII is strongly associated with factor VU[. The association of serum-triglycerides with factor VII

  4. File list: ALL.Brs.50.AllAg.MDA-MB-175-VII [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Brs.50.AllAg.MDA-MB-175-VII hg19 All antigens Breast MDA-MB-175-VII SRX647704 h...ttp://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Brs.50.AllAg.MDA-MB-175-VII.bed ...

  5. File list: Oth.Brs.05.AllAg.MDA-MB-175-VII [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Brs.05.AllAg.MDA-MB-175-VII hg19 TFs and others Breast MDA-MB-175-VII SRX647704... http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.Brs.05.AllAg.MDA-MB-175-VII.bed ...

  6. File list: Oth.Brs.20.AllAg.MDA-MB-175-VII [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Brs.20.AllAg.MDA-MB-175-VII hg19 TFs and others Breast MDA-MB-175-VII SRX647704... http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.Brs.20.AllAg.MDA-MB-175-VII.bed ...

  7. File list: Oth.Brs.50.AllAg.MDA-MB-175-VII [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Brs.50.AllAg.MDA-MB-175-VII hg19 TFs and others Breast MDA-MB-175-VII SRX647704... http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.Brs.50.AllAg.MDA-MB-175-VII.bed ...

  8. File list: ALL.Brs.05.AllAg.MDA-MB-175-VII [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Brs.05.AllAg.MDA-MB-175-VII hg19 All antigens Breast MDA-MB-175-VII SRX647704 h...ttp://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Brs.05.AllAg.MDA-MB-175-VII.bed ...

  9. File list: Oth.Brs.10.AllAg.MDA-MB-175-VII [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Brs.10.AllAg.MDA-MB-175-VII hg19 TFs and others Breast MDA-MB-175-VII SRX647704... http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Oth.Brs.10.AllAg.MDA-MB-175-VII.bed ...

  10. File list: ALL.Brs.10.AllAg.MDA-MB-175-VII [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Brs.10.AllAg.MDA-MB-175-VII hg19 All antigens Breast MDA-MB-175-VII SRX647704 h...ttp://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Brs.10.AllAg.MDA-MB-175-VII.bed ...

  11. A Case of Aplasia Cutis Congenita, Type VII

    Science.gov (United States)

    Lee, Joung Sun; Lee, Jee Bum; Kim, Seong Jin; Won, Young Ho

    2008-01-01

    Aplasia cutis congenita (ACC) is a rare congenital defect in which localized or widespread areas of the skin are absent at birth. In the majority of cases, it is limited to the scalp especially on the vertex although other areas of the body may also be involved. Other congenital malformations can be associated with ACC. We present herein the case of a new born male with unilateral absence of skin on the extensor surface of the right lower leg. There was no associated malformation or skin disease such as blistering or nail abnormailty. According to the classification outlined by Frieden, the condition was diagnosed as type VII aplasia cutis congenita. The treatment of this large ulcer was conservative, wet dressing and prophylactic topical antibiotics. On follow up after 2 years showed that the patient was nearly cured of the ulcer and had only minimal scar formation. PMID:27303163

  12. A bountiful spring harvest

    CERN Multimedia

    2013-01-01

    Although we recently put the clocks forward and spring has officially begun, the view from my window looks more autumnal – befitting of the season of mists and mellow fruitfulness, rather than that of sowing seeds for the future. Which, in a way is appropriate. With the LHC paused, we are reaping a kind of harvest in the form of recognition for our efforts.   Two weeks ago, I was in Edinburgh, on behalf of everyone at CERN, to collect the Edinburgh medal, which we shared with Peter Higgs. I particularly like the citation for this honour: “The Edinburgh Medal is awarded each year to men and women of science and technology whose professional achievements are judged to have made a significant contribution to the understanding and well-being of humanity.” I like this, because it underlines a fact that needs to be shouted louder – that fundamental science does more than build the sum of human knowledge, it is also the foundation of human well-being. A few d...

  13. Spring comes for ATLAS

    CERN Multimedia

    Butin, F.

    2004-01-01

    (First published in the CERN weekly bulletin 24/2004, 7 June 2004.) A short while ago the ATLAS cavern underwent a spring clean, marking the end of the installation of the detector's support structures and the cavern's general infrastructure. The list of infrastructure to be installed in the ATLAS cavern from September 2003 was long: a thousand tonnes of mechanical structures spread over 13 storeys, two lifts, two 65-tonne overhead travelling cranes 25 metres above cavern floor, with a telescopic boom and cradle to access the remaining 10 metres of the cavern, a ventilation system for the 55 000 cubic metre cavern, a drainage system, a standard sprinkler system and an innovative foam fire-extinguishing system, as well as the external cryogenic system for the superconducting magnets and the liquid argon calorimeters (comprising, amongst other things, two helium refrigeration units, a nitrogen refrigeration unit and 5 km of piping for gaseous or liquid helium and nitrogen), not to mention the handling eq...

  14. The effect of neonatal gene therapy on skeletal manifestations in mucopolysaccharidosis VII dogs after a decade.

    Science.gov (United States)

    Xing, Elizabeth M; Knox, Van W; O'Donnell, Patricia A; Sikura, Tracey; Liu, Yuli; Wu, Susan; Casal, Margret L; Haskins, Mark E; Ponder, Katherine P

    2013-06-01

    Mucopolysaccharidosis (MPS) VII is a lysosomal storage disease due to deficient activity of β-glucuronidase (GUSB), and results in glycosaminoglycan accumulation. Skeletal manifestations include bone dysplasia, degenerative joint disease, and growth retardation. One gene therapy approach for MPS VII involves neonatal intravenous injection of a gamma retroviral vector expressing GUSB, which results in stable expression in liver and secretion of enzyme into blood at levels predicted to be similar or higher to enzyme replacement therapy. The goal of this study was to evaluate the long-term effect of neonatal gene therapy on skeletal manifestations in MPS VII dogs. Treated MPS VII dogs could walk throughout their lives, while untreated MPS VII dogs could not stand beyond 6 months and were dead by 2 years. Luxation of the coxofemoral joint and the patella, dysplasia of the acetabulum and supracondylar ridge, deep erosions of the distal femur, and synovial hyperplasia were reduced, and the quality of articular bone was improved in treated dogs at 6 to 11 years of age compared with untreated MPS VII dogs at 2 years or less. However, treated dogs continued to have osteophyte formation, cartilage abnormalities, and an abnormal gait. Enzyme activity was found near synovial blood vessels, and there was 2% as much GUSB activity in synovial fluid as in serum. We conclude that neonatal gene therapy reduces skeletal abnormalities in MPS VII dogs, but clinically-relevant abnormalities remain. Enzyme replacement therapy will probably have similar limitations long-term. Copyright © 2013 Elsevier Inc. All rights reserved.

  15. The Effect of Neonatal Gene Therapy on Skeletal Manifestations in Mucopolysaccharidosis VII Dogs after a Decade

    Science.gov (United States)

    Xing, Elizabeth M.; Knox, Van W.; O'Donnell, Patricia A.; Sikura, Tracey; Liu, Yuli; Wu, Susan; Casal, Margret L.; Haskins, Mark E.; Ponder, Katherine P.

    2013-01-01

    Mucopolysaccharidosis (MPS) VII is a lysosomal storage disease due to deficient activity of β-glucuronidase (GUSB), and results in glycosaminoglycan accumulation. Skeletal manifestations include bone dysplasia, degenerative joint disease, and growth retardation. One gene therapy approach for MPS VII involves neonatal intravenous injection of a gamma retroviral vector expressing GUSB, which results in stable expression in liver and secretion of enzyme into blood at levels predicted to be similar or higher to enzyme replacement therapy. The goal of this study was to evaluate the long-term effect of neonatal gene therapy on skeletal manifestations in MPS VII dogs. Treated MPS VII dogs could walk throughout their lives, while untreated MPS VII dogs could not stand beyond 6 months and were dead by 2 years. Luxation of the coxofemoral joint and the patella, dysplasia of the acetabulum and supracondylar ridge, deep erosions of the distal femur, and synovial hyperplasia were reduced, and the quality of articular bone was improved in treated dogs at 6 to 11 years of age compared with untreated MPS VII dogs at 2 years or less. However, treated dogs continued to have osteophyte formation, cartilage abnormalities, and an abnormal gait. Enzyme activity was found near synovial blood vessels, and there was 2% as much GUSB activity in synovial fluid as in serum. We conclude that neonatal gene therapy reduces skeletal abnormalities in MPS VII dogs, but clinically-relevant abnormalities remain. Enzyme replacement therapy will probably have similar limitations long-term. PMID:23628461

  16. The impact of Title VII on general and pediatric dental education and training.

    Science.gov (United States)

    Ng, Man Wai; Glassman, Paul; Crall, James

    2008-11-01

    The authors describe the impact of the Title VII, Section 747 Training in Primary Care Medicine and Dentistry (Title VII) grant program on the development, growth, and expansion of general and pediatric dentistry residency programs in the United States. They first briefly review the legislative history of the Title VII program as it pertains to dental education, followed by a historical overview of dental education in the United States, including a description of the differences between dental and medical education and the routes to professional practice. The authors then present an extensive assessment of the role of the Title VII grant program in building general and pediatric dental training capacity, diversifying the dental workforce, providing outreach and service to underserved and vulnerable populations, stimulating innovations in dental education, and engaging collaborative and interdisciplinary training with medicine. Finally, the authors call for broadening the scope of the Title VII program to allow for predoctoral training (dental student education) and faculty development in general and pediatric dentistry. In doing so, the Title VII program can more effectively address current and future challenges in dental education, dentist workforce, and disparities in oral health and access to care.This article is part of a theme issue of Academic Medicine on the Title VII health professions training programs.

  17. Tissue Factor–Factor VII Complex as a Key Regulator of Ovarian Cancer Phenotypes

    Directory of Open Access Journals (Sweden)

    Shiro Koizume

    2015-01-01

    Full Text Available Tissue factor (TF is an integral membrane protein widely expressed in normal human cells. Blood coagulation factor VII (fVII is a key enzyme in the extrinsic coagulation cascade that is predominantly secreted by hepatocytes and released into the bloodstream. The TF–fVII complex is aberrantly expressed on the surface of cancer cells, including ovarian cancer cells. This procoagulant complex can initiate intracellular signaling mechanisms, resulting in malignant phenotypes. Cancer tissues are chronically exposed to hypoxia. TF and fVII can be induced in response to hypoxia in ovarian cancer cells at the gene expression level, leading to the autonomous production of the TF–fVII complex. Here, we discuss the roles of the TF–fVII complex in the induction of malignant phenotypes in ovarian cancer cells. The hypoxic nature of ovarian cancer tissues and the roles of TF expression in endometriosis are discussed. Arguments will be extended to potential strategies to treat ovarian cancers based on our current knowledge of TF–fVII function.

  18. Fish Springs weather CY 2010

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Weather data for calendar year 2010 at Fish Springs National Wildlife Refuge. Data is provided for each month and includes maximum temperature, minimum temperature,...

  19. Steller's Eider spring migration surveys

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Annual spring aerial surveys were conducted most years from 1992 to 2008, to monitor the population status and habitat use of Steller's eiders (Polysticta stelleri)...

  20. Biological and phylogenetic characterization of a genotype VII Newcastle disease virus from Venezuela: Efficacy of vaccination

    Science.gov (United States)

    Here we describe the characterization a virulent genotype VII Newcastle disease virus (NDV) from Venezuela and evaluate the efficacy of heterologous genotype commercial vaccination under field and controlled rearing conditions. Biological pathotyping and molecular analysis were applied. Results sh...

  1. Use of recombinant activated factor VII in a case of severe postpartum haemorrhage.

    Science.gov (United States)

    Verre, M; Bossio, F; Mammone, A; Piccirillo, M; Tancioni, F; Varano, M

    2006-02-01

    We describe the case of a 24 year old woman, affected by haemorrhagic shock due to post-partum uterine atony, who underwent an emergency hysterectomy with persistent postoperative bleeding, successfully treated with recombinant activated factor VII (Novoseven).

  2. Viis raamatutäit poola näidendeid / Riina Mägi

    Index Scriptorium Estoniae

    Mägi, Riina, 1957-

    2006-01-01

    Tõlkija Hendrik Lindepuult ilmus viies tõlkekogumik poola dramaturgia tippteoseid tutvustavast sarjast. Seekord said kaante vahele Tadeusz Rozewiczi näidendid "Valge abielu", "Lõks" ja "Vana naine haub"

  3. Prevalence of collagen VII-specific autoantibodies in patients with autoimmune and inflammatory diseases

    OpenAIRE

    Licarete Emilia; Ganz Susanne; Recknagel Martin J; Di Zenzo Giovanni; Hashimoto Takashi; Hertl Michael; Zambruno Giovanna; Hundorfean Gheorghe; Mudter Jonas; Neurath Markus F; Bruckner-Tuderman Leena; Sitaru Cassian

    2012-01-01

    Abstract Background Autoimmunity to collagen VII is typically associated with the skin blistering disease epidermolysis bullosa acquisita (EBA), but also occurs occasionally in patients with systemic lupus erythematosus or inflammatory bowel disease. The aim of our present study was to develop an accurate immunoassay for assessing the presence of autoantibodies against collagen VII in large cohorts of patients and healthy donors. Methods Based on in silico antigenic analysis and previous wetl...

  4. Histopathologic changes of the ear in canine models of mucopolysaccharidosis types I and VII.

    Science.gov (United States)

    Hordeaux, J; Deniaud, J; Bemelmans, I; Bertrand, L; Moreau, S; Amiaud, J; Wyers, M; Cherel, Y; Colle, M-A

    2011-05-01

    Mucopolysaccharidosis (MPS) types I and VII are inborn errors of metabolism caused by mutation of enzymes involved in glycosaminoglycan catabolism, which leads to intralysosomal accumulation of glycosaminoglycans. In children, severe forms of MPS I and VII are characterized by somatic and neurologic manifestations, including a poorly understood hearing loss. The purpose of this study is to describe the age-related histopathologic changes of the ear in spontaneous canine models of MPS I and VII. Pathologic changes in the ear were assessed in MPS I and VII dogs ranging from 1.6 to 9.3 months of age. Paraffin-embedded sections of the whole ear and Epon-embedded semithin sections of the cochlea were examined. The following lesions were blindly scored in the middle and inner ear: inflammation, cells vacuolization, thickening of osseous and membranous structures, perivascular vacuolated macrophages infiltration, and bone resorption. All dogs had lysosomal storage within cells of tympanic membrane, ossicles, tympanic bone and mucosa, cochlear bone, spiral ligament, limbus, and stria vascularis. The MPS I dogs mainly had progressive cochlear lesions. The MPS VII dogs had severe and early middle ear lesions, including chronic otitis media and bone resorption. The MPS I dog only partially recapitulates the pathology seen in humans; specifically, the dog model lacks inflammatory middle ear disease. In contrast, the MPS VII dog has severe inflammatory middle ear disease similar to that reported in the human. In conclusion, the canine MPS VII model appears to be a good model to study MPS VII-related deafness.

  5. The Trigeminal (V) and Facial (VII) Cranial Nerves: Head and Face Sensation and Movement

    OpenAIRE

    Sanders, Richard D

    2010-01-01

    There are close functional and anatomical relationships between cranial nerves V and VII in both their sensory and motor divisions. Sensation on the face is innervated by the trigeminal nerves (V) as are the muscles of mastication, but the muscles of facial expression are innervated mainly by the facial nerve (VII) as is the sensation of taste. This article briefly reviews the anatomy of these cranial nerves, disorders of these nerves that are of particular importance to psychiatry, and some ...

  6. GANGGUAN CEMAS PADA MAHASISWA SEMESTER I DAN VII PROGRAM STUDI PENDIDIKAN DOKTER FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA

    Directory of Open Access Journals (Sweden)

    Dyah Chandratika

    2015-05-01

    Full Text Available Penting untuk dilakukan penelitian mengenai gangguan cemas pada mahasiswa kedokteran karena tingginya tingkat stres mahasiswa terutama pada tahun pertama perkuliahan. Tujuan penelitian ini adalah untuk mengetahui prevalensi dan perbedaan skor  gangguan  cemas  pada mahasiswa  semester  I dan  VII serta untuk  mengetahui perbedaan skor gangguan cemas antara mahasiswa laki-laki dan perempuan di Fakultas Kedokteran Universitas Udayana. Desain penelitian ini adalah cross sectional analitik. Pengambilan sampel dilakukan secara random sampling. Sampel mengisi identitas, kuesioner L-MMPI, kuesioner Hamilton Anxiety Rating Scale (HARS. Kemudian dihitung prevalensi gangguan cemas tiap kelompok serta data dianalisis menggunakan uji t-independen. Terdapat 15 orang (25,0% mahasiswa semester I dan 7 orang (11,7% mahasiswa semester VII yang mengalami gangguan cemas. Dari hasil uji t-independen antara skor gangguan cemas mahasiswa semester I dan VII diperoleh nilai p = 0,001 (<0,05. Sedangkan diperoleh p = 0,080 antara mahasiswa laki-laki dan perempuan pada semester I dan p = 0,744 antara mahasiswa laki-laki dan perempuan pada semester VII. Prevalensi gangguan cemas pada mahasiswa semester I yaitu 25,0% sedangkan 11,7% pada mahasiswa semester VII. Terdapat perbedaan bermakna antara skor gangguan cemas mahasiswa semester I dan VII. Tidak ditemukan perbedaan bermakna skor gangguan cemas antara laki-laki dan perempuan.   

  7. Detection of type VII collagen autoantibodies before onset of bullous systemic lupus erythematosus

    Science.gov (United States)

    Grabell, Daniel A.; Matthews, Loderick A.; Yancey, Kim B.; Chong, Benjamin F.

    2016-01-01

    Importance Anti-type VII collagen autoantibodies are often detectable in patients with bullous systemic lupus erythematosus (BSLE); however their timing of appearance preceding onset of disease is unknown. Observations We report the case of a 50-year-old female with a history of systemic lupus erythematosus who presented with vesicles and bullae around her lips, trunk, axillae, arms, and thighs. Histologic analysis as well as immunofluorescence and immunoblot studies confirmed the diagnosis of BSLE. Immunoblotting and ELISA studies of the patient’s serum obtained three months prior to the onset of BSLE showed presence of anti-type VII collagen autoantibodies. Levels of anti-type VII collagen IgG increased after bullous lesions appeared. Within one month after initiating dapsone and increasing the dose of prednisone, skin lesions promptly resolved. A year after onset of BSLE, her anti-type VII collagen IgG decreased below levels observed prior to the inception of her bullous lesions. Conclusions and Relevance This study shows that anti-type VII collagen autoantibodies can precede the clinical appearance of BSLE. The subsequent increase and decrease in the levels of circulating anti-type VII collagen autoantibodies, which mirrored skin disease activity, support a potential role in their initiation of disease. PMID:25671758

  8. Technetium (VII) fixation in synthetic oxides under aerobic conditions; Fijacion de tecnecio (VII) en oxidos sinteticos en condiciones aerobicas

    Energy Technology Data Exchange (ETDEWEB)

    Arizpe M, L. G. [Instituto Tecnologico de Toluca, Av. Tecnologico s/n, Fraccionamiento La Virgen, 52149 Metepec, Estado de Mexico (Mexico); Badillo A, V. E., E-mail: letygame_06@hotmail.com [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2012-10-15

    The retention of fission products as the technetium in different materials to observe the behavior of anionic species, present in the spent fuel, is of vital importance in the evaluation of the safety of a radioactive waste storage. The radionuclide {sup 99}Tc is one of the fission products of long half life of 2.11 X 10{sup 5} years, which could be liberated in the underground waters that surround to a geologic warehouse of high level wastes, in the chemical form TcO{sub 4}{sup -}, which prevails in aerated solutions since is extremely soluble. In this work was evaluated the use of synthetic oxides as potential adsorbents of the radioactive technetium and to study the importance of the superficial properties of these solids in the radionuclide migration. Two synthetic oxides were studied, the titanium and aluminium oxide. The results demonstrate that the retention of Tc (VII) under aerobic conditions of the solution is worthless in the interval of studied ph of 4 at 9 for both solids; however when the ph of the solution diminishes to ph values of 3, important kD are obtained in the case of the titanium oxide, what shows the importance of the surface properties of these oxides to interpret the radionuclide retention. (Author)

  9. Delayed hypertrophic differentiation of epiphyseal chondrocytes contributes to failed secondary ossification in mucopolysaccharidosis VII dogs.

    Science.gov (United States)

    Peck, Sun H; O'Donnell, Philip J M; Kang, Jennifer L; Malhotra, Neil R; Dodge, George R; Pacifici, Maurizio; Shore, Eileen M; Haskins, Mark E; Smith, Lachlan J

    2015-11-01

    Mucopolysaccharidosis (MPS) VII is a lysosomal storage disorder characterized by deficient β-glucuronidase activity, which leads to the accumulation of incompletely degraded glycosaminoglycans (GAGs). MPS VII patients present with severe skeletal abnormalities, which are particularly prevalent in the spine. Incomplete cartilage-to-bone conversion in MPS VII vertebrae during postnatal development is associated with progressive spinal deformity and spinal cord compression. The objectives of this study were to determine the earliest postnatal developmental stage at which vertebral bone disease manifests in MPS VII and to identify the underlying cellular basis of impaired cartilage-to-bone conversion, using the naturally-occurring canine model. Control and MPS VII dogs were euthanized at 9 and 14 days-of-age, and vertebral secondary ossification centers analyzed using micro-computed tomography, histology, qPCR, and protein immunoblotting. Imaging studies and mRNA analysis of bone formation markers established that secondary ossification commences between 9 and 14 days in control animals, but not in MPS VII animals. mRNA analysis of differentiation markers revealed that MPS VII epiphyseal chondrocytes are unable to successfully transition from proliferation to hypertrophy during this critical developmental window. Immunoblotting demonstrated abnormal persistence of Sox9 protein in MPS VII cells between 9 and 14 days-of-age, and biochemical assays revealed abnormally high intra and extracellular GAG content in MPS VII epiphyseal cartilage at as early as 9 days-of-age. In contrast, assessment of vertebral growth plates and primary ossification centers revealed no significant abnormalities at either age. The results of this study establish that failed vertebral bone formation in MPS VII can be traced to the failure of epiphyseal chondrocytes to undergo hypertrophic differentiation at the appropriate developmental stage, and suggest that aberrant processing of Sox9 protein

  10. Dietary changes in fasting levels of factor VII coagulant activity (FVII:C) are accompanied by changes in factor VII protein and other vitamin K-dependent proteins

    DEFF Research Database (Denmark)

    Bladbjerg, Else-Marie; Tholstrup, T; Marckmann, P

    1995-01-01

    The mechanisms behind dietary effects on fasting coagulant activity of factor VII (FVII:C) are not clarified. In the present study of 15 young volunteers, two experimental diets differing in composition of saturated fatty acids (C18:0 [diet S] or C12:0 + C14:0 [diet ML]) were served for 3 weeks...

  11. Instant Spring for Android starter

    CERN Document Server

    Dahanne, Anthony

    2013-01-01

    Packt Instant Starter: get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks.This is a Starter which gives you an introduction to Spring for Android with plenty of well-explained practical code examples.If you are an Android developer who wants to learn about RESTful web services and OAuth authentication and authorization, and you also want to know how to speed up your development involving those architectures using Spring for Android abstractions, then this book is for you.But core Java developers

  12. Providing culturally competent care: residents in HRSA Title VII funded residency programs feel better prepared.

    Science.gov (United States)

    Green, Alexander R; Betancourt, Joseph R; Park, Elyse R; Greer, Joseph A; Donahue, Elizabeth J; Weissman, Joel S

    2008-11-01

    The Health Resources and Services Administration (HRSA) funds primary care residency programs through its Title VII training grants, with a goal of ensuring a well-prepared, culturally competent physician workforce. The authors sought to determine whether primary care residents in Title VII-funded training programs feel better prepared than those in nonfunded programs to provide care to culturally diverse patients. The authors analyzed data from a national mailed survey of senior resident physicians conducted in 2003-2004. Of 1,467 randomly selected family medicine, internal medicine, and pediatrics residents, 866 responded--403 in Title VII-funded programs and 463 in nonfunded programs (response rate = 59%). The survey included 28 Likert-response questions about residents' preparedness and perceived skills to provide cross-cultural care, sociodemographics, and residency characteristics. Residents in Title VII-funded programs were more likely than others to report being prepared to provide cross-cultural care across all 8 measures (odds ratio [OR] = 1.54-2.61, P experience related to cross-cultural care (e.g., role models, cross-cultural training, and attitudes of attending physicians) accounted for many of the differences in self-reported preparedness and skills. Senior residents in HRSA Title VII-funded primary care residency training programs feel better prepared than others to provide culturally competent care. This may be partially explained by better cross-cultural training experiences in HRSA Title VII-funded programs.This article is part of a theme issue of Academic Medicine on the Title VII health professions training programs.

  13. Strategi Peningkatan Kualitas Pelayanan Jasa Transportasi Kereta Api (Studi Pada PT. Kereta Api Indonesia (Persero) Dearah Operasi VII Madiun)

    OpenAIRE

    Tri Juliyanto, Ilham

    2015-01-01

    : Quality Improvement Strategy Railway Transportation Services (Studi pada PT. Kereta Api Indonesia (Persero) Daerah Operasi VII Madiun). This research intended to discover the strategic which applied by PT. KAI DAOP VII Madiun for increasing the quality of service in train transportation, supporting factor and inhibiting factor strategic in increase of quality of service of PT. KAI DAOP VII Madiun. In this research, uses descriptive research with qualitative approach and use analysis method ...

  14. Research Synopsis: Spring 1983 Retention.

    Science.gov (United States)

    Peralta Community Coll. District, Oakland, CA. Office of Research, Planning and Development.

    An analysis of spring 1983 retention rates and grade distributions within the Peralta Community College District (PCCD) revealed: (1) College of Alameda had the highest successful retention rate in the PCCD, defined as the total of all students who completed the term with a grade of A, B, C, D, or CR (credit); (2) the PCCD's successful retention…

  15. Spring for It: First Novels

    Science.gov (United States)

    Hoffert, Barbara

    2010-01-01

    How do publishers describe the first novels they will be releasing this spring and summer? "Amazing," "fabulous," and "unique" are words that pop up frequently, though hats off to one publicist forthright or cheeky enough to call a work "weird Western/horror." The proof of such praise is in the reading, but why not check out this preview of first…

  16. A Laboratory of Spring. Introduction

    Directory of Open Access Journals (Sweden)

    Witold Wachowski

    2013-12-01

    Full Text Available Introduction to a special issue published on the occasion of the 100th anniversary of the premiere of 'The Rite of Spring' by Igor Stravinsky. The articles cover the field of musicology as well as history, philosophy, psychology, sociology, ethnography and cognitive science of music.

  17. Finding Spring on Planet X

    Science.gov (United States)

    Simoson, Andrew J.

    2007-01-01

    For a given orbital period and eccentricity, we determine the maximum time lapse between the winter solstice and the spring equinox on a planet. In addition, given an axial precession path, we determine the effects on the seasons. This material can be used at various levels to illustrate ideas such as periodicity, eccentricity, polar coordinates,…

  18. Optimization of holddown spring in KOFA

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Jung Sik; Lee, Jae Kyung; Sohn, Dong Sung [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1994-08-01

    As a part of establishment of capability for design change and optimization of fuel components, the analysis method of holddown spring was improved and the optimization capability for the holddown spring was established. With the improved analysis method the characteristics of 17 x 17 holddown spring of KOFA and straight type holddown spring were analyzed and the results were compared with test results. It showed that the improved analysis method predicts the spring characteristic well agree with the test results. As an example of an optimization, the thickness of straight type holddown spring was optimized and the characteristic with this thickness was discussed. (Author) 39 figs., 2 tabs.

  19. Technetium (VII) Co-precipitation with Framework Aluminosilicates

    Energy Technology Data Exchange (ETDEWEB)

    Harsh, James B. [Washington State Univ., Pullman, WA (United States); Dickson, Johnbull Otah [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pierce, Eric M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bargar, John [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-07-13

    Technetium-99 (99Tc), a long-lived radionuclide, is one of the most widespread contaminants within the Hanford subsurface. At some depths, it is only extractable with strong acids, suggesting incorporation into a solid phase. We hypothesized that Tc may have coprecipitated with feldspathoid aluminosilicates under waste tanks that had leaked caustic solutions into the vadose zone. Our objectives were to determine if Tc could be incorporated into the feldspathoids cancrinite and sodalite and under what conditions coprecipitation could occur. Our hypothesis was that sodalite was more likely to incorporate and retain Tc. Our approach was to use known methods of feldspathoid formation in solutions resembling those in Hanford waste tanks contacting sediments in terms of major ion (Na, NO3, OH, Al(OH)4, and Si(OH)4 concentrations. In some cases, Al and Si were supplied from zeolite. We used perrhenate (ReO4) as a surrogate for pertechnetate (TcO4) to avoid the radioactivity. The major findings of this study were 1) ReO4 could be incorporated into either sodalite or cancrinite but the concentration in the solid was < 1% of the competing ion Cl, NO3, or NO2. 2) The small amount of ReO4 incorporated was not exchangeable with NO3 or NO2. 3) In sodalite, NO3 was highly preferred over ReO4 but significant Re-sodalite was formed when the mole fraction in solution (Re/Re+N) exceeded 0.8. 4) A nonlinear relation between the unit cell parameter and amount of Re incorporated suggested that a separate Re-sodalite phase was formed rather than a solid solution. 5) We determined that sodalite preference for sodalite in the presence of different anions increased with the ionic size of the competing anion: Cl < CO3 < NO3 < SO4 < MnO4 < WO4 and significant incorporation did not occur unless the difference in anion radii was less than 12%. 6) Re(VII) was not significantly reduced to Re(IV) under the conditions of this experiment and Re appeared to be a good surrogate for Tc under oxidizing

  20. Portrait of a Geothermal Spring, Hunter's Hot Springs, Oregon.

    Science.gov (United States)

    Castenholz, Richard W

    2015-01-27

    Although alkaline Hunter's Hot Springs in southeastern Oregon has been studied extensively for over 40 years, most of these studies and the subsequent publications were before the advent of molecular methods. However, there are many field observations and laboratory experiments that reveal the major aspects of the phototrophic species composition within various physical and chemical gradients of these springs. Relatively constant temperature boundaries demark the upper boundary of the unicellular cyanobacterium, Synechococcus at 73-74 °C (the world-wide upper limit for photosynthesis), and 68-70 °C the upper limit for Chloroflexus. The upper limit for the cover of the filamentous cyanobacterium, Geitlerinema (Oscillatoria) is at 54-55 °C, and the in situ lower limit at 47-48 °C for all three of these phototrophs due to the upper temperature limit for the grazing ostracod, Thermopsis. The in situ upper limit for the cyanobacteria Pleurocapsa and Calothrix is at ~47-48 °C, which are more grazer-resistant and grazer dependent. All of these demarcations are easily visible in the field. In addition, there is a biosulfide production in some sections of the springs that have a large impact on the microbiology. Most of the temperature and chemical limits have been explained by field and laboratory experiments.

  1. The effect of Simvastatin upon serum pseudocholinesterase and plasmatic factor VII.

    Science.gov (United States)

    Zdrenghea, D; Bodizs, G; Predescu, D; Oprea, M; Zdrenghea, M

    2002-01-01

    The statins have a moderate lowering effect upon triglycerides, one hypothesis suggesting an inhibitory effect upon liver VLDL synthesis. Because VLDL synthesis is related to other hepatic protein synthesis we studied the effect of Simvastatin upon serum cholinesterase activity and factor VII activity, which are also synthetized at hepatic level. 39 patients with ischaemic heart disease, proved by coronarography and moderate hypercholesterolaemia received for two months 20 mg Simvastatin (Zocor). The value of total Co, LDLCo, HDLCo, triglycerides, serum cholinesterase activity and factor VII activity were determined before and after treatment, by standard methods. Triglycerides were, together with total Co, significantly lowered during the two months treatment with Simvastatin, but the values of serum cholinesterase and factor VII activity were not significantly modified. This suggests that moderate doses of Simvastatin do not depress liver protein synthesis. Simvastatin does not lower the triglycerides level through depression of liver protein syntesis, other mechanisms being probably involved.

  2. Cross-reactivity of autoantibodies from patients with epidermolysis bullosa acquisita with murine collagen VII.

    Science.gov (United States)

    Csorba, Kinga; Sesarman, Alina; Oswald, Eva; Feldrihan, Vasile; Fritsch, Anja; Hashimoto, Takashi; Sitaru, Cassian

    2010-04-01

    The pathomechanism of antibody-mediated tissue damage in autoimmune diseases can be best studied in experimental models by passively transferring specific autoantibodies into animals. The reproduction of the disease in animals depends on several factors, including the cross-reactivity of patient autoantibodies with the animal tissue. Here, we show that autoantibodies from patients with epidermolysis bullosa acquisita (EBA), a subepidermal autoimmune blistering disease, recognize multiple epitopes on murine collagen VII. Indirect immunofluorescence microscopy revealed that EBA patients' IgG cross-reacts with mouse skin. Overlapping, recombinant fragments of murine collagen VII were used to characterize the reactivity of EBA sera and to map the epitopes on the murine antigen by ELISA and immunoblotting. The patients' autoantibody binding to murine collagen VII triggered pathogenic events as demonstrated by a complement fixing and an ex vivo granulocyte-dependent dermal-epidermal separation assay. These findings should greatly facilitate the development of improved disease models and novel therapeutic strategies.

  3. Triangular springs for modeling nonlinear membranes.

    Science.gov (United States)

    Delingette, Hervé

    2008-01-01

    This paper provides a formal connexion between springs and continuum mechanics in the context of one-dimensional and two-dimensional elasticity. In a first stage, the equivalence between tensile springs and the finite element discretization of stretching energy on planar curves is established. Furthermore, when considering a quadratic strain function of stretch, we introduce a new type of springs called tensile biquadratic springs. In a second stage, we extend this equivalence to non-linear membranes (St Venant-Kirchhoff materials) on triangular meshes leading to triangular biquadratic and quadratic springs. Those tensile and angular springs produce isotropic deformations parameterized by Young modulus and Poisson ratios on unstructured meshes in an efficient and simple way. For a specific choice of the Poisson ratio, 0.3, we show that regular spring-mass models may be used realistically to simulate a membrane behavior. Finally, the different spring formulations are tested in pure traction and cloth simulation experiments.

  4. Fish Springs NWR Water Use Report : 2010

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report contains locations and water use at Fish Springs National Wildlife Refuge (NWR) for 2010. A general background is presented on historical spring water...

  5. Wavelengths and energy levels of Xe VII and Xe VIII obtained by collision-based spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Larsson, M.O. [Uppsala Univ. (Sweden). Dept. of Theoretical Physics; Gonzalez, A.M. [Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas (CIEMAT), Madrid (Spain). Inst. de Investigacion Basica; Hallin, R. [Uppsala Univ. (Sweden). Dept. of Theoretical Physics; Heijkenskjoeld, F. [Uppsala Univ. (Sweden). Dept. of Theoretical Physics; Hutton, R. [Lund Univ. (Sweden). Dept. of Physics; Langereis, A. [Uppsala Univ. (Sweden). Dept. of Theoretical Physics; Nystroem, B. [Lund Univ. (Sweden). Dept. of Physics; O`Sullivan, G. [University Coll., Dublin (Ireland). Dept. of Physics; Waennstroem, A. [Uppsala Univ. (Sweden). Dept. of Theoretical Physics

    1995-01-01

    The Xe VII and Xe VIII spectra have been investigated by collision-based spectroscopy. The radiation emitted following electron capture by 10q keV Xe{sup q+} ions (q = 6-8) impinging on a He (Ar) gas target has, with some exceptions, been recorded in the 350-8000 (1200-2500) A wavelength region. The xenon ions were provided by the Uppsala University ECR ion source. Many of the observed, previously unreported spectral lines have been identified. In total, nine new energy levels of Xe VII and Xe VIII have been established, of which two are tentative. The analysis was supported by Hartree-Fock calculations. (orig.).

  6. Dove sta andando l'analisi musicale? Riflessioni sul VII EuroMac

    Directory of Open Access Journals (Sweden)

    Mario Baroni

    2014-01-01

    Full Text Available Come tutti i lettori della Rivista ormai sapranno, si è svolto a Roma dal 29 settembre al 2 ottobre di quest’anno, presso il Conservatorio di S. Cecilia, il settimo convegno europeo di analisi musicale (VII European Music Analysis Conference ossia VII EuroMac. Nel convegno, organizzato dal GATM e diretto da Giorgio Sanguinetti, sono state presentate 197 relazioni e svolti otto laboratori. Tutti i materiali sono stati riassunti in un volume (Programme and Abstract Book, Iter Edizioni di Subiaco curato da Egidio Pozzi e Antonio Cascelli.

  7. Spring Framework 5: Themes & Trends

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    Spring Framework 5.0/5.1, scheduled for release in early/late 2017, focuses on several key themes: reactive web applications based on Reactive Streams, comprehensive support for JDK 9 and HTTP/2, as well as the latest API generations in the Enterprise Java ecosystem. This talk presents the overall story in the context of wider industry trends, highlighting Spring’s unique programming model strategy.

  8. The first CERN Spring Campus

    CERN Multimedia

    CERN Bulletin

    2014-01-01

    From 14 to 16 April, the first edition of the CERN Spring Campus took place in Spain. Taking place over three intensive days, this event brought experts from CERN together at the University of Oviedo, where they met the engineers and scientists of the future in a programme of scientific and technological dissemination and cultural exchange.   The young participants of the first CERN Spring Campus and their instructors show their enthusiasm after the intensive three-day course. “This three-day school focuses on preparing young engineers for the job market, with a particular emphasis on computing,” explains Derek Mathieson, Advanced Information Systems Group Leader in the GS Department and Head of the CERN Spring Campus organising committee. “We organised talks on entrepreneurship and IT, as well as on job interviews and CV writing. It was also an important opportunity for the participants to meet CERN computing engineers to find out what it is like to work in I...

  9. 75 FR 39241 - Hooper Springs Project

    Science.gov (United States)

    2010-07-08

    ... Bonneville Power Administration Hooper Springs Project AGENCY: Bonneville Power Administration (BPA... Hooper Springs Project). The new BPA substation would be called Hooper Springs Substation and would be... 115-kV Lane Creek Substation, east of the City of Wayan, Idaho. The proposed project would address...

  10. 49 CFR 236.822 - Switch, spring.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Switch, spring. 236.822 Section 236.822 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Switch, spring. A switch equipped with a spring device which forces the points to their original position...

  11. Contact activation and factor VII after the use of an activated prothrombin complex concentrate (FEIBA) in hemophiliacs with inhibitors.

    Science.gov (United States)

    Mariani, G; Bouma, B N; Mazzucconi, M G; Avvisati, G; Di Nucci, G D; Corrao, D; Mandelli, F

    1983-08-01

    Administration of a brand of activated prothrombin complex concentrate (FEIBA) to hemophiliacs with high-titre inhibitor to factor VIII, induced a shortening of the prothrombin time and thrombotest clotting time. This effect stems partly from the presence in the concentrate of high amounts of activated factor VII (alpha-VII a) which indeed after the infusion, were detected in the plasma of Hemophiliacs. The attained levels of factor alpha-VII a were shown to be proportional to the dose of concentrate administered. This form of activated factor VII was not generated as a result of activation of the contact activation mechanism, since after the infusion of the concentrate no changes were detected in the components of this system. The infused factor VII was indeed present in an activated form and this was further substantiated by the infusion of the concentrate in factor VII deficient patients. These observations suggest that factor alpha-VII a is not generated in vivo and thus is of exogenous origin. The clinical effect may well be due to the presence of this form of activated factor VII; in this context the alternative pathway involving factors IX and X should be implicated.

  12. 40 CFR Appendix Vii to Part 266 - Health-Based Limits for Exclusion of Waste-Derived Residues*

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Health-Based Limits for Exclusion of Waste-Derived Residues* VII Appendix VII to Part 266 Protection of Environment ENVIRONMENTAL PROTECTION...-Based Limits for Exclusion of Waste-Derived Residues* Metals—TCLP Extract Concentration Limits...

  13. Dietary effects on coagulation factor VII vary across genotypes of the R/Q353 polymorphism in elderly people

    NARCIS (Netherlands)

    Mennen, L.I.; Maat, M.P.M. de; Schouten, E.G.; Kluft, C.; Witteman, J.C.M.; Hofman, A.; Grobbee, D.E.

    1998-01-01

    The objective of this study was to evaluate the association of factor VII with dietary factors while also considering the R/Q353 polymorphism. Nutrition is an important determinant of coagulation factor VII, which is also genetically determined by the R/Q353 polymorphism. High levels of coagulation

  14. ESEA Title VII Bilingual/Bicultural Education Program; Programa de Educacion Bilingue/Bicultural 1975-1976.

    Science.gov (United States)

    Milwaukee Public Schools, WI. Dept. of Educational Research and Program Assessment.

    This is the annual evaluation report of the Title VII components of the Milwaukee Bilingual/Bicultural Education Program funded by Title I and Title VII of the Elementary and Secondary Education Act of 1967 and the Milwaukee Public Schools. The results of the 1975-76 assessment of pupil progress toward achievement of the program's academic and…

  15. Effects of different progestin regimens in hormone replacement therapy on blood coagulation factor VII and tissue factor pathway inhibitor

    DEFF Research Database (Denmark)

    Bladbjerg, E-M; Skouby, S O.; Andersen, L F

    2002-01-01

    BACKGROUND: Long-term hormone replacement therapy (HRT) reduces cardiovascular risk, but an early increased risk was reported in women with coronary heart disease. In such women the arterial intima can express tissue factor, and changes in coagulation factor VII (factor VII) and tissue factor...

  16. Antimicrobial peptide scolopendrasin VII, derived from the centipede Scolopendra subspinipes mutilans, stimulates macrophage chemotaxis via formyl peptide receptor 1.

    Science.gov (United States)

    Park, Yoo Jung; Lee, Ha Young; Jung, Young Su; Park, Joon Seong; Hwang, Jae Sam; Bae, Yoe-Sik

    2015-08-01

    In this study, we report that one of the antimicrobial peptides scolopendrasin VII, derived from Scolopendra subspinipes mutilans, stimulates actin polymerization and the subsequent chemotactic migration of macrophages through the activation of ERK and protein kinase B (Akt) activity. The scolopendrasin VII-induced chemotactic migration of macrophages is inhibited by the formyl peptide receptor 1 (FPR1) antagonist cyclosporine H. We also found that scolopendrasin VII stimulate the chemotactic migration of FPR1-transfected RBL-2H3 cells, but not that of vector-transfected cells; moreover, scolopendrasin VII directly binds to FPR1. Our findings therefore suggest that the antimicrobial peptide scolopendrasin VII, derived from Scolopendra subspinipes mutilans, stimulates macrophages, resulting in chemotactic migration via FPR1 signaling, and the peptide can be useful in the study of FPR1-related biological responses.

  17. Spring Recipes A Problem-solution Approach

    CERN Document Server

    Long, Josh; Mak, Gary

    2010-01-01

    With over 3 Million users/developers, Spring Framework is the leading "out of the box" Java framework. Spring addresses and offers simple solutions for most aspects of your Java/Java EE application development, and guides you to use industry best practices to design and implement your applications. The release of Spring Framework 3 has ushered in many improvements and new features. Spring Recipes: A Problem-Solution Approach, Second Edition continues upon the bestselling success of the previous edition but focuses on the latest Spring 3 features for building enterprise Java applications.

  18. Coexistence of Factor VII Deficiency and Hereditary Spastic Paraplegia in Two Siblings

    Directory of Open Access Journals (Sweden)

    Hortensia De la Corte-Rodriguez

    2016-01-01

    Full Text Available We present the case of two patients aged 12 years and 7 years who were referred to our hospital for factor VII deficiency inherited in an autosomal recessive pattern, who had suffered from previous multiple joint haemarthroses. They presented with fine motor symptoms and difficulty in walking. During physical examination we observed neurological symptoms (general hypotonia, muscular hypotrophy, exaggerated tendon reflexes, pes cavus, and spastic gait. Given that the symptoms were not justified by the deficiency of coagulation factor VII and on suspicion of hereditary spastic paraplegia (HSP, tests were carried out. Findings from the tests confirmed the diagnosis of HSP (axonal degeneration of the central motor pathway and pyramidal tracts, further complicated by mixed neuropathy. This disease was also inherited in an autosomal recessive pattern with no direct genetic association with factor VII deficiency. Neurological symptoms had gone unnoticed due to a history of multiple joint haemarthrosis; musculoskeletal examination led to a satisfactory differential diagnosis. Haematological prophylaxis was commenced with rFVIIa at 30 mcg/kg, three days per week. A rehabilitation programme was prescribed so that the patient could remain independent for as long as possible, based on orthosis, physiotherapy, and occupational therapy. Response to treatment is currently satisfactory and no new bleeding has presented. As far as we are aware, the coexistence of these two diseases (factor VII deficiency and HSP has not been previously reported in the literature.

  19. Contribution of coagulation factor VII R353Q polymorphism to the ...

    African Journals Online (AJOL)

    Hanan Azzam

    2016-12-05

    Dec 5, 2016 ... a b s t r a c t. Background: Elevated factor VII (FVII) level is a risk factor for thromboembolic disorders. It was reported that the FVII R353Q polymorphism is associated with variation in plasma FVII levels, where Q allele car- ..... and von Willebrand factor: the CHARGE (Cohorts for Heart and Aging Research.

  20. PENGARUH KUALITAS SISTEM DAN INFORMASI TERHADAP KEPUASAN PEMAKAI SISTEM ERP PADA PT TELKOM DIVRE VII MAKASSAR

    OpenAIRE

    ARRESKI, DWI FITRA

    2014-01-01

    2014 Penelitian ini bertujuan untuk menganalisis pengaruh kualitas sistem dan informasi terhadap kepuasan pemakai sistem ERP pada PT Telkom Divre VII Makassar. Pengumpulan data dilakukan dengan menggunakan kuesioner yang diberikan kepada 132 responden sebagai pengguna sistem ERP. Data diolah dengan menggunakan analisis regresi berganda. Temuan penelitian menunjukkan bahwa kualitas sistem memiliki pengaruh positif terhadap ...

  1. Strangers No More: All Workers are Entitled to "Just Cause" Protection under Title VII.

    Science.gov (United States)

    Blumrosen, Alfred W.

    1978-01-01

    Examines the work of administrative agencies and courts in processing discrimination claims under Title VII (equal employment opportunity) of the Civil Rights Act of 1964, concluding that the common law rule of employer discretion has been superseded by the principle of just cause in personnel decisions. (MF)

  2. Factor VII-activating protease : Unraveling the release and regulation of dead cell nuclear damps

    NARCIS (Netherlands)

    Marsman, G.

    2017-01-01

    Upon inflammation, uncleared dying cells are an important source of pro-inflammatory damage-associated molecular patterns (DAMPs). Major DAMPs are histones and double-stranded DNA, which together form chromatin. Factor VII-activating protease (FSAP) is activated upon contact with dead cells, and its

  3. Presidendi teenetemärgi pälvis viis spordiinimest

    Index Scriptorium Estoniae

    2008-01-01

    Vt. ka Linnaleht : Tartu 7. veebr., lk. 7. Eesti riigile osutatud teenete eest pälvisid president Toomas Hendrik Ilveselt teenetemärgi viis spordieluga seotud inimest: jalgpallikoondise ekstreenerid Jelle Goes ja Arno Pijpers, kergejõustikutreener Vésteinn Hafsteinsson, sõudetreener Tatjana Jaanson ning spordielu edendaja Nora Kutti. Juuresoleval fotol Jelle Goes

  4. Investigating the air oxidation of V(II) ions in a vanadium redox flow battery

    Science.gov (United States)

    Ngamsai, Kittima; Arpornwichanop, Amornchai

    2015-11-01

    The air oxidation of vanadium (V(II)) ions in a negative electrolyte reservoir is a major side reaction in a vanadium redox flow battery (VRB), which leads to electrolyte imbalance and self-discharge of the system during long-term operation. In this study, an 80% charged negative electrolyte solution is employed to investigate the mechanism and influential factors of the reaction in a negative-electrolyte reservoir. The results show that the air oxidation of V(II) ions occurs at the air-electrolyte solution interface area and leads to a concentration gradient of vanadium ions in the electrolyte solution and to the diffusion of V(II) and V(III) ions. The effect of the ratio of the electrolyte volume to the air-electrolyte solution interface area and the concentrations of vanadium and sulfuric acid in an electrolyte solution is investigated. A higher ratio of electrolyte volume to the air-electrolyte solution interface area results in a slower oxidation reaction rate. The high concentrations of vanadium and sulfuric acid solution also retard the air oxidation of V(II) ions. This information can be utilized to design an appropriate electrolyte reservoir for the VRB system and to prepare suitable ingredients for the electrolyte solution.

  5. 78 FR 36011 - Region VII Regulatory Fairness Board; Federal Regulatory Enforcement Fairness Hearing

    Science.gov (United States)

    2013-06-14

    ... ADMINISTRATION Region VII Regulatory Fairness Board; Federal Regulatory Enforcement Fairness Hearing AGENCY: U.S... Business Regulatory Fairness Board. SUMMARY: The (SBA) Office of the National Ombudsman is issuing this notice to announce the location, date and time of the Regional Small Business Regulatory Fairness hearing...

  6. Last Hired, First Fired Seniority, Layoffs, and Title VII: Questions of Liability and Remedy

    Science.gov (United States)

    Joseph, Ellen R.

    1975-01-01

    The severe economic downturn since the fall of 1973 has focused attention on the consequences of layoffs for the groups intended by Congress to benefit from the employment opportunity policies of Title VII of the Civil Rights Act of 1964. Layoffs have disproportionately affected minority or women employees. (LBH)

  7. Page 1 396 R. D. Desai and (Miss) W. M. Vakil (VII) and its alcoholic ...

    Indian Academy of Sciences (India)

    (VII) and its alcoholic solution gave a red coloration with ferric chloride. (yield 42 per cent). (Found: C, 647; H, 46; CH, Os requires C, 65.0;. H, 4.5 per cent). The sodium bicarbonate solution, on acidification, gave an acid which is described below. Hydrolysis of methyl 2:4-dihydroxy-3-benzoyl-5-acetylbenzoate to 2:4-.

  8. Eesti lavastus "Põrgu wärk" võitis Balti teatrifestivalil viis auhinda

    Index Scriptorium Estoniae

    2006-01-01

    Balti teatrifestivalil "OmaDraama 2006" nähtud etendustest said viis auhinda eestlased - Mart Kivastik näidendi "Põrgu Wärk" eest, Hendrik Toompere lavastuse eest, Harriet Toompere naisosatäitmise eest, Jan Uuspõld Wiiralti kehastamise eest ning Margus Prangel Tuglase osa eest

  9. "Põrgu wärk" võitis Balti teatrifestivalil viis auhinda

    Index Scriptorium Estoniae

    2006-01-01

    Balti teatrifestivalil "OmaDraama 2006" nähtud etendustest said viis auhinda eestlased - Mart Kivastik näidendi "Põrgu Wärk" eest, Hendrik Toompere lavastuse eest, Harriet Toompere naisosatäitmise eest, Jan Uuspõld Wiiralti kehastamise eest ning Margus Prangel Tuglase osa eest. Ka teistest festivalil auhinnasaajatest

  10. Three-dimensional ultrasonography for visualization of muscular anomalies in type VI and VII radial polydactyly.

    Science.gov (United States)

    Saito, Susumu; Ueda, Maho; Takahashi, Natsuko; Kawakatsu, Motohisa; Suzuki, Shigehiko

    2016-04-01

    To describe a technique and its clinical applications of three-dimensional ultrasonography to type VI and VII radial polydactyly for identification of potential muscular anomalies. Ultrasonographic examinations were performed at an out-patient department without sedation or an operative room prior to surgery. The palm was scanned in the transverse direction using a 18-MHz linear transducer under speed regulation at 3 mm/s. Sequential images acquired at 0.2 mm intervals were converted into volume data. After validation of the technique, patients with a radial polydactyly in association with triphalangism (type VII) or with polydactylies of metacarpal duplication (type VI) were included for the examination. Five hands of five patients, one with type VI and four with type VII, were included the study. All the patients were male and the ages at examination ranged from 7 months to 2 years. Of the five patients, four examinations were performed at an out-patient department without sedation and one was under anesthesia just prior to surgery. The muscular abnormalities identified were mal-positions of the thenar muscles in a type VI case and a deficiency of the abductor pollicis brevis muscle in a type VII case with a delta phalanx in the ulnar part. Three-dimensional ultrasound technique could be an aid to plan strategies in radial polydactyly if intrinsic muscular anomalies are suspected to be involved.

  11. Fernando VII against the journalists. Litigations by the State Lawsuit Commission

    Directory of Open Access Journals (Sweden)

    Beatriz Sánchez Hita

    2017-09-01

    Full Text Available This paper deals with the documents associated to the litigations against editors and journalists stored in the State Lawsuit Commission (Madrid, Spain. These files illustrate the persecution of those who tried to create a pro-constitutional public opinion, the aspects which were received as important affronts by Fernando VII and the defendants’ strategies to be penalized as less as possible.

  12. Vittorio De Sica viis meistritööd / Aare Ermel

    Index Scriptorium Estoniae

    Ermel, Aare, 1957-2013

    2008-01-01

    DVD-st "Vittorio De Sica Masterpiece Collection", kus on peal itaalia filmirežissööri Vittorio De Sica viis teost: "Jalgratavargad" ("Ladri di biciclette", 1948), "Ime Milanos" ("Miraclo a milano", 1951), "Umberto D." (1952), "Eile täna, homme" ("Ieri, oggi, domani", 1963), "Ajatu filmikunst" ("Cinema senza tempo: Cosi e la vita", 2001)

  13. Plasma fibrinogen and factor VII concentrations in adults after prenatal exposure to famine

    NARCIS (Netherlands)

    Roseboom, T. J.; van der Meulen, J. H.; Ravelli, A. C.; Osmond, C.; Barker, D. J.; Bleker, O. P.

    2000-01-01

    To assess the effect of maternal malnutrition during different stages of gestation on plasma concentrations of fibrinogen and factor VII, we investigated 725 people, aged 50 years, born around the time of the Dutch famine 1944-5. After adjustment for sex, plasma fibrinogen concentrations differed by

  14. Hormone therapy affects plasma measures of factor VII-activating protease in younger postmenopausal women

    DEFF Research Database (Denmark)

    Mathiasen, Jørn Sidelmann; Skouby, S.O.; Vitzthum, F.

    2010-01-01

    Objectives Current reviews indicate that hormone therapy (HT) has a protective role in coronary heart disease (CHD) in younger postmenopausal women, whereas HT contributes to CHD in older women Factor VII-activating protease (FSAP) is a serine protease that accumulates in unstable atherosclerotic...

  15. Factor VII-activating protease in patients with acute deep venous thrombosis

    DEFF Research Database (Denmark)

    Sidelmann, Johannes J; Vitzthum, Frank; Funding, Eva

    2008-01-01

    Factor VII-activating protease (FSAP) is involved in haemostasis and inflammation. FSAP cleaves single chain urokinase-type plasminogen activator (scu-PA). The 1601GA genotype of the 1601G/A polymorphism in the FSAP gene leads to the expression of a FSAP variant with reduced ability to activate scu...

  16. Synthesis and characterization of 18F-labeled active site inhibited factor VII (ASIS)

    DEFF Research Database (Denmark)

    Erlandsson, Maria; Nielsen, Carsten Haagen; Jeppesen, Troels Elmer

    2015-01-01

    Activated factor VII blocked in the active site with Phe-Phe-Arg-chloromethyl ketone (active site inhibited factor VII (ASIS)) is a 50-kDa protein that binds with high affinity to its receptor, tissue factor (TF). TF is a transmembrane glycoprotein that plays an important role in, for example......, thrombosis, metastasis, tumor growth, and tumor angiogenesis. The aim of this study was to develop an 18F-labeled ASIS derivative to assess TF expression in tumors. Active site inhibited factor VII was labeled using N-succinimidyl-4-[18F]fluorobenzoate, and the [18F]ASIS was purified on a PD-10 desalting...... column. The radiochemical yield was 25 ± 6%, the radiochemical purity was >97%, and the pseudospecific radioactivity was 35 ± 9 GBq/µmol. The binding efficacy was evaluated in pull-down experiments, which monitored the binding of unlabeled ASIS and [18F]ASIS to TF and to a specific anti-factor VII...

  17. Association of protein Z and factor VII gene polymorphisms with risk ...

    Indian Academy of Sciences (India)

    Abstract. Protein Z (PZ) and factor (F) VII are two important factors in the clotting pathway which have similar structure, linked function and nearby gene sites. The aims of this study were to investigate whether the common variants of PZ and FVII genes are associated with the risk of cerebral hemorrhage (CH) and to explore ...

  18. What history tells us VII. Twenty-five years ago: the production of ...

    Indian Academy of Sciences (India)

    2006-11-13

    Nov 13, 2006 ... Home; Journals; Journal of Biosciences; Volume 31; Issue 5. What history tells us VII. Twenty-five years ago: the production of mouse embryonic stem cells. Michel Morange. Series Volume 31 Issue 5 December 2006 pp 537-541. Fulltext. Click here to view fulltext PDF. Permanent link:

  19. Contribution of coagulation factor VII R353Q polymorphism to the ...

    African Journals Online (AJOL)

    Aim of the study: Is to investigate the contribution of factor VII R353Q gene polymorphism to the risk of thrombotic disorders development (venous and arterial) in a group of Egyptian patients. Subjects and methods: This study was conducted on 310 subjects: 110 acute myocardial infarction (AMI) patients, 108 deep venous ...

  20. Dos Idiomas, Un Mundo. Dual Language Project. Title VII Biennial Evaluation Report, 1995-97.

    Science.gov (United States)

    Ernest, Harishini M.; Gonzalez, Rosa M.

    This is an evaluation of the first 2 years of a 5-year comprehensive Bilingual Education grant funded by Title VII Part A of the Improving America's Schools Act of 1994 in the Austin Independent School District (AISD) (Texas). The grant awarded to the AISD funds a program of Developmental Bilingual Education at two elementary schools where more…

  1. PEMBELAJARAN MENULIS PARAGRAF DESKRIPSI BERBASIS MIND MAPPING PADA SISWA KELAS VII SMP LABORATORIUM UNDIKSHA

    Directory of Open Access Journals (Sweden)

    Ida Bagus Putrayasa

    2015-10-01

    Full Text Available Tujuan penelitian ini untuk mendeskripsikan: (1 pembelajaran menulis paragraf deskripsi dengan model mind mapping pada siswa kelas VII SMP Laboratorium Undiksha Singaraja, (2 kemampuan siswa kelas VII SMP Laboratorium Undiksha Singaraja dalam pembelajaran menulis paragraf deskripsi dengan mind mapping. Rancangan yang digunakan dalam penelitian ini adalah penelitian deskriptif kualitatif. Yang menjadi subjek dalam penelitian ini adalah guru dan siswa kelas VII SMP Laboratorium Undiksha. Objek dalam penelitian ini adalah pembelajaran paragraf deskripsi dengan model mind mapping. Metode yang digunakan untuk mengumpulkan data adalah metode observasi dan metode tes. Data yang terkumpul dianalisis dengan metode analisis deskriptif kualitatif dan deskriptif kuantitatif. Hasilnya menunjukkan bahwa (1 Pembelajaran menulis paragraf deskripsi dengan model mind mapping yang dilakukan guru sudah sesuai dengan teori yang ada. (2 Kemampuan siswa kelas VII SMP Laboratorium Undiksha dalam menulis paragraf deskripsi tergolong baik. Skor yang diperoleh adalah 78,13. Walaupun skor yang diperoleh sudah mencapai kategori baik, tampaknya kinerja guru perlu ditingkatkan lagi dengan memberikan latihan-latihan yang lebih intensif, baik dalam membuat mind mapping maupun pengembangannya menjadi paragraf, sehingga tercapai hasil yang maksimal.

  2. Responsiveness summary for the remedial investigation/feasibility study for management of the bulk wastes at the Weldon Spring quarry, Weldon Spring, Missouri

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, J.M.; MacDonell, M.M.

    1990-08-01

    The US Department of Energy (DOE) is responsible for conducting remedial actions at the Weldon Spring site in St. Charles County, Missouri, under its Surplus Facilities Management Program. The site consists of a quarry and a chemical plant area located about 6.4 km (4 mi) northeast of the quarry. The quarry is surrounded by the Weldon Spring Wildfire Area and is near an alluvial well field that constitutes a major source of potable water for St. Charles County; the nearest supply well is located about 0.8 km (0.5 mi) southeast of the quarry. From 1942 to 1969, the quarry was used for the disposal of various radioactively and chemically contaminated materials. Bulk wastes in the quarry consist of contaminated soils and sediments, rubble, metal debris, and equipment. As part of overall site remediation, DOE is proposing to conduct an interim remedial action at the quarry to manage the radioactively and chemically contaminated bulk wastes contained therein. Potential remedial action alternatives for managing the quarry bulk wastes have been evaluated consistent with US Environmental Protection Agency (EPA) guidance for conducting remedial actions under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), as amended. The contents of these documents were developed in consultation with EPA Region VII and the state of Missouri and reflect the focused scope defined for this interim remedial action. 9 refs.

  3. Prevalence of collagen VII-specific autoantibodies in patients with autoimmune and inflammatory diseases.

    Science.gov (United States)

    Licarete, Emilia; Ganz, Susanne; Recknagel, Martin J; Di Zenzo, Giovanni; Hashimoto, Takashi; Hertl, Michael; Zambruno, Giovanna; Hundorfean, Gheorghe; Mudter, Jonas; Neurath, Markus F; Bruckner-Tuderman, Leena; Sitaru, Cassian

    2012-04-04

    Autoimmunity to collagen VII is typically associated with the skin blistering disease epidermolysis bullosa acquisita (EBA), but also occurs occasionally in patients with systemic lupus erythematosus or inflammatory bowel disease. The aim of our present study was to develop an accurate immunoassay for assessing the presence of autoantibodies against collagen VII in large cohorts of patients and healthy donors. Based on in silico antigenic analysis and previous wetlab epitope mapping data, we designed a chimeric collagen VII construct containing all collagen VII epitopes with higher antigenicity. ELISA was performed with sera from patients with EBA (n = 50), Crohn's disease (CD, n = 50), ulcerative colitis (UC, n = 50), bullous pemphigoid (BP, n = 76), and pemphigus vulgaris (PV, n = 42) and healthy donors (n = 245). By ELISA, the receiver operating characteristics analysis yielded an area under the curve of 0.98 (95% CI: 0.9638-1.005), allowing to set the cut-off at 0.32 OD at a calculated specificity of 98% and a sensitivity of 94%. Running the optimized test showed that serum IgG autoantibodies from 47 EBA (94%; 95% CI: 87.41%-100%), 2 CD (4%; 95% CI: 0%-9.43%), 8 UC (16%; 95% CI: 5.8%-26%), 2 BP (2.63%; 95% CI: 0%-6.23%), and 4 PV (9.52%; 95% CI: 0%-18.4%) patients as well as from 4 (1.63%; 95% CI: 0%-3.21%) healthy donors reacted with the chimeric protein. Further analysis revealed that in 34%, 37%, 16% and 100% of sera autoantibodies of IgG1, IgG2, IgG3, and IgG4 isotype, respectively, recognized the recombinant autoantigen. Using a chimeric protein, we developed a new sensitive and specific ELISA to detect collagen specific antibodies. Our results show a low prevalence of collagen VII-specific autoantibodies in inflammatory bowel disease, pemphigus and bullous pemphigoid. Furthermore, we show that the autoimmune response against collagen VII is dominated by IgG4 autoantibodies. The new immunoassay should prove a useful tool for clinical and translational

  4. Prevalence of collagen VII-specific autoantibodies in patients with autoimmune and inflammatory diseases

    Directory of Open Access Journals (Sweden)

    Licarete Emilia

    2012-04-01

    Full Text Available Abstract Background Autoimmunity to collagen VII is typically associated with the skin blistering disease epidermolysis bullosa acquisita (EBA, but also occurs occasionally in patients with systemic lupus erythematosus or inflammatory bowel disease. The aim of our present study was to develop an accurate immunoassay for assessing the presence of autoantibodies against collagen VII in large cohorts of patients and healthy donors. Methods Based on in silico antigenic analysis and previous wetlab epitope mapping data, we designed a chimeric collagen VII construct containing all collagen VII epitopes with higher antigenicity. ELISA was performed with sera from patients with EBA (n = 50, Crohn's disease (CD, n = 50, ulcerative colitis (UC, n = 50, bullous pemphigoid (BP, n = 76, and pemphigus vulgaris (PV, n = 42 and healthy donors (n = 245. Results By ELISA, the receiver operating characteristics analysis yielded an area under the curve of 0.98 (95% CI: 0.9638-1.005, allowing to set the cut-off at 0.32 OD at a calculated specificity of 98% and a sensitivity of 94%. Running the optimized test showed that serum IgG autoantibodies from 47 EBA (94%; 95% CI: 87.41%-100%, 2 CD (4%; 95% CI: 0%-9.43%, 8 UC (16%; 95% CI: 5.8%-26%, 2 BP (2.63%; 95% CI: 0%-6.23%, and 4 PV (9.52%; 95% CI: 0%-18.4% patients as well as from 4 (1.63%; 95% CI: 0%-3.21% healthy donors reacted with the chimeric protein. Further analysis revealed that in 34%, 37%, 16% and 100% of sera autoantibodies of IgG1, IgG2, IgG3, and IgG4 isotype, respectively, recognized the recombinant autoantigen. Conclusions Using a chimeric protein, we developed a new sensitive and specific ELISA to detect collagen specific antibodies. Our results show a low prevalence of collagen VII-specific autoantibodies in inflammatory bowel disease, pemphigus and bullous pemphigoid. Furthermore, we show that the autoimmune response against collagen VII is dominated by IgG4 autoantibodies. The new immunoassay should

  5. CACTUS SPRING ROADLESS AREA, CALIFORNIA.

    Science.gov (United States)

    Matti, Jonathan C.; Kuizon, Lucia

    1984-01-01

    Geologic, geochemical, and geophysical studies together with a review of historic mining and prospecting activities indicate that the Cactus Spring Roadless Area in California has little promise for the occurrence of mineral or energy resources. Marble bodies occur in the northern part of the roadless area and are possible resources for building stone, crushed and quarried aggregate, and lime and magnesium for Portland cement and industrial applications. It is recommended that the terrane of marble be mapped and sampled carefully in order to evaluate the quantity and quality of the carbonate resources.

  6. Structural study on 2,2'-(methylimino)bis(N,N-dioctylacetamide) complex with Re(VII)O4- and Tc(VII)O4- by 1H NMR, EXAFS, and IR spectroscopy.

    Science.gov (United States)

    Saeki, Morihisa; Sasaki, Yuji; Nakai, Ayaka; Ohashi, Akira; Banerjee, Dipanjan; Scheinost, Andreas C; Foerstendorf, Harald

    2012-05-21

    The structures of the complex of 2,2'-(methylimino)bis(N,N-dioctylacetamide) (MIDOA) with M(VII)O(4)(-) (M = Re and Tc), which were prepared by liquid-liquid solvent extraction, were investigated by using (1)H nuclear magnetic resonance (NMR), extended X-ray absorption fine structure (EXAFS), and infrared (IR) spectroscopy. The (1)H NMR spectra of the complex of MIDOA with Re(VII)O(4)(-) prepared in the organic solution suggest the transfer of a proton from aqueous to organic solution and the formation of the H(+)MIDOA ion. The EXAFS spectra of the complexes of H(+)MIDOA with Re(VII)O(4)(-) and Tc(VII)O(4)(-) show only the M-O coordination of the aquo complexes, suggesting that the chemical state of M(VII)O(4)(-) was unchanged during the extraction process. The results from (1)H NMR and EXAFS, therefore, provide evidence of M(VII)O(4)(-)···H(+)MIDOA complex formation in the organic solution. The IR spectra of Re(VII)O(4)(-)···H(+)MIDOA and Tc(VII)O(4)(-)···H(+)MIDOA were analyzed based on the structures and the IR spectra that were calculated at the B3LYP/cc-pVDZ level. Comparison of the observed and calculated IR spectra demonstrates that an intramolecular hydrogen bond is formed in H(+)MIDOA, and the M(VII)O(4)(-) ion interacts with H(+)MIDOA through multiple C-H(n)···O hydrogen bonds.

  7. Genetic diversity of the genotype VII Newcastle disease virus: identification of a novel VIIj sub-genotype.

    Science.gov (United States)

    Xue, Cong; Cong, Yanlong; Yin, Renfu; Sun, Yixue; Ding, Chan; Yu, Shengqing; Liu, Xiufan; Hu, Shunlin; Qian, Jing; Yuan, Qianliang; Yang, Mingxi; Wang, Chunfeng; Ding, Zhuang

    2017-02-01

    Newcastle disease (ND) is a highly contagious disease of poultry caused by Newcastle disease virus (NDV). Multiple genotypes of NDV have been circulating worldwide and NDV is continuously evolving, resulting into more diversity. Of multiple viral genotypes, VII is particularly important given that it had been associated with most recent ND outbreaks worldwide. In this study, an epidemiological investigation performed in northeastern China during 2014-2015 showed that 11 genotype VII isolates amounted to 55 percent in a total number of NDV isolates. Therefore, to evaluate the genetic diversity worldwide and epidemiological distribution in China of genotype VII NDV, a phylogenetic analysis based on the 1255 complete F gene sequences showed that VII is the most predominant genotype worldwide. A further detailed characterization on genotype VII was conducted based on the 477 complete F gene sequences from 11 isolates and 466 reference viruses available in GenBank. The results demonstrated that VII can be further divided into 8 sub-genotypes (VIIb, VIId-VIIj), indicating its complex genetic diversity. It is worthy of note that the isolation rate of VIIj is increasing recently. It emphasizes the necessity to pay close attention to the epidemiological dynamic of genotype VII NDV and highlights the importance of vaccination program.

  8. Oxidation of triclosan by permanganate (Mn(VII)): importance of ligands and in situ formed manganese oxides.

    Science.gov (United States)

    Jiang, Jin; Pang, Su-Yan; Ma, Jun

    2009-11-01

    Experiments were conducted to examine permanganate (Mn(VII); KMnO(4)) oxidation of the widely used biocide triclosan (one phenolic derivative) in aqueous solution at pH values of 5-9. Under slightly acidic conditions, the reactions displayed autocatalysis, suggesting the catalytic role of in situ formed MnO(2). This was further supported by the promoting effects of the addition of preformed MnO(2) colloids on Mn(VII) oxidations of triclosan and two other selected phenolics (i.e., phenol and 2,4-dichlorophenol), as well as p-nitrophenol which otherwise showed negligible reactivity toward Mn(VII) and MnO(2) colloids, respectively. Surprisingly, phosphate buffer significantly enhanced Mn(VII) oxidation of triclosan, as well as phenol and 2,4-dichlorophenol over a wide pH range. Further, several other selected ligands (i.e., pyrophosphate, EDTA, and humic acid) also exerted oxidation enhancement, supporting a scenario where highly active aqueous manganese intermediates (Mn(INT)(aq)) formed in situ upon Mn(VII) reduction might be stabilized to a certain extent in the presence of ligands and subsequently involved in further oxidation of target phenolics, whereas without stabilizing agents Mn(INT)(aq) autodecomposes or disproportionates spontaneously. The effectiveness of Mn(VII) for the oxidative removal of triclosan in natural water and wastewater was confirmed. Their background matrices were also found to accelerate Mn(VII) oxidation of phenolics.

  9. Pseudane-VII Isolated from Pseudoalteromonas sp. M2 Ameliorates LPS-Induced Inflammatory Response In Vitro and In Vivo

    Directory of Open Access Journals (Sweden)

    Mi Eun Kim

    2017-11-01

    Full Text Available The ocean is a rich resource of flora, fauna, food, and biological products. We found a wild-type bacterial strain, Pseudoalteromonas sp. M2, from marine water and isolated various secondary metabolites. Pseudane-VII is a compound isolated from the Pseudoalteromonas sp. M2 metabolite that possesses anti-melanogenic activity. Inflammation is a response of the innate immune system to microbial infections. Macrophages have a critical role in fighting microbial infections and inflammation. Recent studies reported that various compounds derived from natural products can regulate immune responses including inflammation. However, the anti-inflammatory effects and mechanism of pseudane-VII in macrophages are still unknown. In this study, we investigated the anti-inflammatory effects of pseudane-VII. In present study, lipopolysaccharide (LPS-induced nitric oxide (NO production was significantly decreased by pseudane-VII treatment at 6 μM. Moreover, pseudane-VII treatment dose-dependently reduced mRNA levels of pro-inflammatory cytokines including inos, cox-2, il-1β, tnf-α, and il-6 in LPS-stimulated macrophages. Pseudane-VII also diminished iNOS protein levels and IL-1β secretion. In addition, Pseudane-VII elicited anti-inflammatory effects by inhibiting ERK, JNK, p38, and nuclear factor (NF-κB-p65 phosphorylation. Consistently, pseudane-VII was also shown to inhibit the LPS-stimulated release of IL-1β and expression of iNOS in mice. These results suggest that pseudane-VII exerted anti-inflammatory effects on LPS-stimulated macrophage activation via inhibition of ERK, JNK, p38 MAPK phosphorylation, and pro-inflammatory gene expression. These findings may provide new approaches in the effort to develop anti-inflammatory therapeutics.

  10. Robert oerley and Tuzla mineral springs

    OpenAIRE

    Ateş Can, Sevim

    2014-01-01

    In the Tuzla borough of İstanbul are located mineral springs of great importance which have been known and used since ancient times. Although the therapeutic value of Tuzla Mineral Springs has always been recognized, this value in terms of the history of architecture has not been very well understood. The current facilities in the springs were built in the Republican Period. The most important among them is the Spa Hotel, whose project was initiated by Robert Oerley. The oth...

  11. Radon activity measurements around Bakreswar thermal springs

    Energy Technology Data Exchange (ETDEWEB)

    Chaudhuri, Hirok [Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata, West Bengal 700 064 (India); Das, Nisith K., E-mail: nkdas@veccal.ernet.i [Variable Energy Cyclotron Centre, Atomic Energy, 1/AF Bidhannagar, Kolkata, West Bengal 700 064 (India); Bhandari, Rakesh K. [Variable Energy Cyclotron Centre, Atomic Energy, 1/AF Bidhannagar, Kolkata, West Bengal 700 064 (India); Sen, Prasanta [Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata, West Bengal 700 064 (India); Sinha, Bikash [Variable Energy Cyclotron Centre, Atomic Energy, 1/AF Bidhannagar, Kolkata, West Bengal 700 064 (India)

    2010-01-15

    {sup 222}Rn concentrations were measured in the bubble gases, spring waters, soil gases and in ambient air around the thermal springs at Bakreswar in West Bengal, India. This group of springs lies within a geothermal zone having exceptionally high heat flow about 230 mW/m{sup 2}, resembling young oceanic ridges. The spring gas has a high radon activity (approx885 kBq/m{sup 3}) and is rich in helium (approx1.4 vol. %) with appreciably large flow rate. The measured radon exhalation rates in the soils of the spring area show extensive variations from 831 to 4550/mBqm{sup 2} h while {sup 222}Rn concentrations in the different spring waters vary from 3.18 to 46.9 kBq/m{sup 3}. Surface air at a radius of 40 m around the springs, within which is situated the Bakreswar temple complex and a group of dwellings, has radon concentration between 450 and 500 Bq/m{sup 3}. In the present paper we assess the radon activity background in and around the spring area due to the different contributing sources and its possible effect on visiting pilgrims and the people who reside close to the springs.

  12. Work Term Assignment Spring 2017

    Science.gov (United States)

    Sico, Mallory

    2017-01-01

    My tour in the Engineering Robotics directorate exceeded my expectations. I learned lessons about Creo, manufacturing and assembly, collaboration, and troubleshooting. During my first tour, last spring, I used Creo on a smaller project, but had limited experience with it before starting in the Dynamic Systems Test branch this spring. I gained valuable experience learning assembly design, sheet metal design and designing with intent for manufacturing and assembly. These skills came from working both on the hatch and the floor. I also learned to understand the intent of other designers on models I worked with. While redesigning the floor, I was modifying an existing part and worked to understand what the previous designer had done to make it fit with the new model. Through working with the machine shop and in the mock-up, I learned much more about manufacturing and assembly. I used a Dremel, rivet gun, belt sander, and countersink for the first time. Through taking multiple safety training for different machine shops, I learned new machine shop safety skills specific to each one. This semester also gave me new collaborative opportunities. I collaborated with engineers within my branch as well as with Human Factors and the building 10 machine shop. This experience helped me learn how to design for functionality and assembly, not only for what would be easiest in my designs. In addition to these experiences, I learned many lessons in troubleshooting. I was the first person in my office to use a Windows 10 computer. This caused unexpected issues with NASA services and programs, such as the Digital Data Management Server (DDMS). Because of this, I gained experience finding solutions to lockout and freeze issues as well as Creo specific settings. These will be useful skills to have in the future and will be implemented in future rotations. This co-op tour has motivated me more to finish my degree and pursue my academic goals. I intend to take a machining Career Gateway

  13. Úvodník 2012/VII/2

    Directory of Open Access Journals (Sweden)

    Jana Dlouhá

    2012-09-01

    Full Text Available Úvodník 2012/VII/22012-09-15 00:00:00Vážení naši přátelé a příznivci,Envigogika se vám opět hlásí, v době, kdy podzim je definitivně zde a my jsme se zase vrátili do škol. A protože se v takovém čase začíná opakováním, zrekapitulujeme si tuto naši situaci i my. Dnes a každý všední den sedí v lavicích základních škol v naší zemi něco přes ¾ milionu dětí, a z těchto dětí později více nežli dvě třetiny dokončí ještě stupně další, absolvují školy střední nebo vysoké. Jestliže před padesáti lety počet lidí s nejméně výučním listem nedosahoval ani 20 % populace (maturitu či vysokoškolský titul mělo jen 10% dospělého obyvatelstva, kdežto 80 % připadalo na ty, kteří vychodili pouze školu základní, v současné době je tomu přesně naopak (nejméně maturitu má skoro polovina lidí, a vyučených je více než třetina. Takže nakonec počet těch, co mají pouze vzdělání základní, jen o málo převyšuje počet vysokoškoláků (17 resp. 12 %, a podíl této „intelektuální elity“ stále stoupá – ale pozor, stoupá i množství lidí tzv. bez vzdělání [1]. Vypadá to tedy, že všichni se stále více zabýváme činností vysoce abstraktní, a věci obyčejné ztrácejí svoji cenu. Jsme vzdělanější, proto(že život jednotlivce je stále složitější, a také chod společnosti se proměnil na složitou technologii. Prostor, kde se mohou projevit přirozené touhy či rozhodnutí, se tak ale stále zmenšuje a je také čím dál těžší jej znovu otevírat či bránit. V tomto vysoce sofistikovaném, na údržbu náročném světě se dobře daří především systémům jeho správy, přičemž služba těmto systémům stojí většinu myšlenkové energie nás všech. Na tom jistě není nic špatného – pokud by technologie této správy či údržby soustavně neodvracela pozornost od toho, co má být spravováno. A tak právě v

  14. Úvodník 2012/VII/1

    Directory of Open Access Journals (Sweden)

    Jana Dlouhá

    2012-05-01

    Full Text Available Úvodník 2012/VII/12012-05-31 13:31:41Vážení přátelé, příznivci EnvigogikyPřipomínáme se vám v době „přelomu věků“ – tedy co se týče dějů přírodních nebo toho, co s ní zamýšlíme my lidé. Slunovrat již překlopil letošní léto do fáze ubývání. A co se týče všeobecné porady o stavu světa, ta právě skončila v brazilském Riu.Sluneční cykly mají vliv na nás, naše cítění, skrze ně prožíváme i vztah k přírodě a vlastně i kosmickým dějům. I této cykličnosti života se pokoušíme vymanit a tak si mnozí dopřávají dovolenou v jiném ročním období, než je právě u nich doma. Je ale otázkou, zda pocit domova není spjat i s jakousi základní naladěností na přírodní děje. Někdy může být osvěžující domov opustit, ale to, co je základem jeho prožívání, jakási prapůvodní konstelace já – zde (byť právě jinde, tyto souřadnice člověk potřebuje mít pořád při sobě. Je asi dobré umět spolu s přírodou procítit, co se právě děje (například se účastnit slunečního „přelomu“ právě teď, aby člověk byl připraven i na přelomy jiné, životní, také cyklické…Na rozdíl od této velmi dobře předvídatelné a jisté změny (třebaže je postřehnutelná pouze v kontextu celého léta, se očekávaný přelom v Riu (nekonal, a jak to dopadlo, teprve uvidíme, protože to celé je plně na nás. Jisté je, že to byl velký strategický zápas, jak si v té všeobecné snaze o jedno společné dobro uchovat možnost vlastního, soukromého individuálního prospěchu navzdory všem racionálním argumentům. My lidé v této dualitě žijeme, takže to tak asi být má – za podmínky, že se nevytratí ona idea a účinná snaha ji uskutečnit (což jak víme nejde, ale zrovna tak nejde se o to stále nepokoušet, protože pak by nic nemělo smysl. No a protože to vypadá, že takřka všichni vládci sv

  15. Imagining Ferdinand VII, a Catholic and felon King | Imaginando a Fernando VII, rey católico y felón

    Directory of Open Access Journals (Sweden)

    Gregorio Alonso

    2015-12-01

    Full Text Available The public image of King Ferdinand VII (1784-1833 was built through a process of exaltation and sacralization as a result of the Napoleonic invasion of the Iberian Peninsula that started in the fall of 1807. This article tackles the mechanisms put in place in order to achieve such a target. It also unravels the ways in which wide sectors of the Catholic clergy collaborated in the identification of the King’s image with that of the Spanish nation in danger. The text also sheds light on the American dimensions of the divinization of kingship and their limits in a period of rapid and violent change in the colonies. | La imagen pública del rey Fernando VII (1784-1833 fue sometida a un proceso de exaltación y sacralización a raíz de la invasión napoleónica de la Península Ibérica iniciada en el otoño de 1807. Este artículo aborda los mecanismos que se emplearon para lograr dicho objetivo y la plena colaboración de amplios sectores del clero para identificar al rey con la nación en peligro. El texto vierte luz sobre las dimensiones americanas de dicho fenómeno de divinización regia y sus limitaciones en un periodo de rápido y violento cambio en las colonias.

  16. Uso de fator VII recombinante ativado para tratamento e profilaxia de grandes sangramentos Use of recombinant activated factor VII for treatment and prophylaxis of major bleeding

    Directory of Open Access Journals (Sweden)

    Flávio Augusto Henriques Vince

    2009-09-01

    Full Text Available INTRODUÇÃO: O fator VII recombinante ativado (rFVIIa é uma proteína produzida por engenharia genética, cuja estrutura é muito semelhante à do fator VII intrínseco ativado (FVII. Sua ação se baseia no conhecimento do mecanismo de coagulação in vivo agindo na ativação direta do fator X resultando em formação independente de trombina no local da lesão e contribuindo dessa forma para formação de coágulo estável de fibrina sem a ação dos fatores VIII e IX. MÉTODOS: Foi realizada ampla revisão da literatura com o objetivo de determinar os achados recentes relacionados ao uso de fator VII recombinante ativado em pacientes com sangramento severo. RESULTADOS: Constatou-se que o uso de rFVIIa foi iniciado na década de 80 para profilaxia e tratamento de sangramento em pacientes com antecedente de hemofilia A ou B com inibidores de fator VIII e IX, deficiência de fator VII e trombastenia de Glanzmann refratários à reposição plaquetária. Em 1999 seu uso foi ampliado para outras situações clínicas e dessa forma, começaram a ser publicados diversos trabalhos mostrando a eficácia do rFVIIa como agente pró-hemostático em paciente com outras coagulopatias ou pacientes previamente hígidos com história de sangramento agudo de grande monta. Trauma é a principal causa de mortalidade no mundo sendo sangramento incontrolado o principal desafio no atendimento a estes pacientes. É comum a associação de trauma com coagulopatia, necessitando em algumas situações de terapia específica para o tratamento da mesma. Neste momento a terapia adjuvante com rFVIIa deve ser considerada. Outras causas comuns de sangramento são as operações cardíacas e ginecológicas/ obstétricas e doenças envolvendo o fígado. A coagulopatia nesses casos ocorre por deficiência dos fatores dependentes de vitamina K, sendo o FVII o com menor meia-vida. CONCLUSÃO: O uso de rFVIIa tem sido sugerido como opção terapêutica promissora para esses

  17. Path-integral simulation of ice VII: Pressure and temperature effects

    CERN Document Server

    Herrero, Carlos P

    2015-01-01

    Effects of pressure and temperature on structural and thermodynamic properties of ice VII have been studied by using path-integral molecular dynamics (PIMD) simulations. Temperatures between 25 and 450 K, as well as pressures up to 12 GPa were considered. Interatomic interactions were modeled by using the effective q-TIP4P/F potential for flexible water. We analyze the pressure dependence of the molar volume, bulk modulus, interatomic distances, kinetic energy, and atomic delocalization at various temperatures. Results of PIMD simulations are compared with those derived from a quasi-harmonic approximation (QHA) of vibrational modes, which helps to assess the importance of anharmonic effects, as well as the influence of the different modes on the properties of ice VII. The accuracy of the QHA for describing this high-pressure phase decreases for rising temperature, but this approximation becomes more reliable as pressure grows, since anharmonicity becomes less relevant. Comparisons with low-pressure cubic ice ...

  18. Análise dos Resultados da VII Olimpíada Brasileira de Astronomia

    Science.gov (United States)

    Garcia Canalle, João Batista; Villas da Rocha, Jaime Fernando; Wuensche de Souza, Carlos Alexandre; Aguilera, Nuricel Villalonga; Preta Padilha, Maria De Fátima Catta; de Medeiros, José Renan; Dantas, Márcia Pragano; Roque da Silva, Adriana; Martins, Roberto Vieira; Dottori, Horácio Alberto; Maia, Márcio Antonio Geimba; Da Rocha Poppe, Paulo César; Rodrigues da Costa, Antônio Carlos

    2006-06-01

    In this work we show the results of the VII Brazilian Astronomy Olympiad (VII OBA), that occurred on 15/05/2004, in all previous registered elementary and high schools, public and/or private, urban and/or rural. Took part in this Olympiad 123.001 students (60,7 % more than VI OBA), distributed over 2.721 schools (increasing of 73% if compared with the VI OBA), belonging to all Brazilian states. The public schools are 75,5% and the private are 24,5%. The team of 4 students selected in the VI OBA (2003) represented the Brazil in the IX International Astronomy Olympiad (IX IAO), that occurred on October of 2004, in Ukraine and won a silver medal and two bronze medals.

  19. 34 CFR 364.2 - What is the purpose of the programs authorized by chapter 1 of title VII?

    Science.gov (United States)

    2010-07-01

    ... SILS and CIL programs authorized by chapter 1 of title VII of the Act is to promote a philosophy of independent living (IL), including a philosophy of consumer control, peer support, self-help, self...

  20. Rheological behavior of a confined bead-spring cube consisting of equal Fraenkel springs

    NARCIS (Netherlands)

    Denneman, A.I.M.; Denneman, A.I.M.; Jongschaap, R.J.J.; Mellema, J.

    2000-01-01

    A general bead-spring model is used to predict linear viscoelastic properties of a non-Hookean bead-spring cube immersed in a Newtonian fluid. This K×K×K cube consist of K 3 beads with equal friction coefficients and 3K 2(K–1) equal Fraenkel springs with length q. The cube has a topology based upon

  1. Analisis Pelaksanaan Program Kemitraan Bumn terhadap Kesejahteraan UMKM: Pendekatan Corporate Responsibility (CSR). (Studi Kasus PTPN VII)

    OpenAIRE

    Mukhan, Unang; Pratama, Maulana Agung

    2012-01-01

    Partnership and Environment Development Program is the implementation of Corporate Social Responsibility (CSR) in State Owned Enterprises (SOEs). Policy Partnership program is very interesting in terms of implementation that much getting about whether the purpose of the provision of an effective CSR program and on target. Descriptive and explanatory research was conducted in partner SMEs assisted PTPN VII. The independent variable used is CSR goal (X1), CSR issue (X2) and...

  2. Redox reactions of Tc{sup VII} with magnetite and mackinawite. Solving an old enigma

    Energy Technology Data Exchange (ETDEWEB)

    Yalcintas, E.; Gaona, X.; Altmeier, M. [Karlsruhe Institute of Technology (KIT), Karlsruhe (Germany). Inst. for Nuclear Waste Disposal; Scheinost, Andreas C. [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Molecular Structures

    2017-06-01

    While the reduction of heptavalent technetium, Tc(VII), by magnetite and mackinawite under anoxic conditions is well known, the identification of the resulting Tc(IV) species shows substantial disagreement between different studies. Here we use a systematic variation of initial Tc concentration, loading and pH to decipher the Tc species by EXAFS spectroscopy and to shine light on their formation pathways.

  3. Technetium(VII,IV) retention by iron(II)-containing minerals

    Energy Technology Data Exchange (ETDEWEB)

    Schmeide, Katja; Spranger, F.; Franzen, Carola; Weiss, Stephan; Heim, Karsten; Foerstendorf, Harald; Bok, Frank [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Div. Surface Processes; Kvashnina, Kristina O. [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Div. Molecular Structures

    2016-07-01

    The Tc retention by the iron(II)-containing minerals magnetite (Fe{sup II}Fe{sup III}{sub 2}O{sub 4}) and siderite (Fe{sup II}CO{sub 3}) was studied by means of batch sorption experiments as well as ATR FT-IR and XAS spectroscopy. The strong Tc retention could be attributed to surface-mediated reduction of Tc(VII) to Tc(IV).

  4. Elmo Bumpy Torus proof of principle, Phase II: Title 1 report. Volume VII. Cryogenic system

    Energy Technology Data Exchange (ETDEWEB)

    Poteat, T.J.

    1982-02-26

    This document, Volume VII EBT-P Cryogenic System Title I Design Report, describes the system that resulted from the Title I Preliminary Design effort. It is a self-contained document that can be read apart from the other Volumes comprising the EBT-P Title I Report. This document is a contract deliverable item and provides the detail necessary to support the Cryogenic System design contained in the EBT-P Baseline Design Data Book (BDDB).

  5. Release of the ENDF/B-VII.1 Evaluated Nuclear Data File

    Energy Technology Data Exchange (ETDEWEB)

    Brown, David

    2012-06-30

    The Cross Section Evaluation Working Group (CSEWG) released the ENDF/B-VII.1 library on December 22, 2011. The ENDF/B-VII.1 library is CSEWG's latest recommended evaluated nuclear data file for use in nuclear science and technology applications, and incorporates advances made in the five years since the release of ENDF/B-VII.0, including: many new evaluation in the neutron sublibrary (423 in all and over 190 of these contain covariances), new fission product yields and a greatly improved decay data sublibrary. This summary barely touches on the five years worth of advances present in the ENDF/B-VII.1 library. We expect that these changes will lead to improved integral performance in reactors and other applications. Furthermore, the expansion of covariance data in this release will allow for better uncertainty quantification, reducing design margins and costs. The ENDF library is an ongoing and evolving effort. Currently, the ENDF data community embarking on several parallel efforts to improve library management: (1) The adoption of a continuous integration system to provide evaluators 'instant' feedback on the quality of their evaluations and to provide data users with working 'beta' quality libraries in between major releases. (2) The transition to new hierarchical data format - the Generalized Nuclear Data (GND) format. We expect GND to enable new kinds of evaluated data which cannot be accommodated in the legacy ENDF format. (3) The development of data assimilation and uncertainty propagation techniques to enable the consistent use of integral experimental data in the evaluation process.

  6. Desain Pembelajaran Materi Belah Ketupat Menggunakan Kain Jumputan Palembang untuk Siswa Kelas VII

    Directory of Open Access Journals (Sweden)

    Fauziyah Fauziyah

    2016-06-01

    Full Text Available Desain pembelajaran materi belah ketupat menggunakan kain Jumputan Palembang untuk siswa kelas VII. Penelitian ini bertujuan untuk melihat bagaimana penggunaan kain Jumputan Palembang dalam membangun pemahaman siswa mengenai belah ketupat. Siswa akan membandingkan luas daerah dua buah kain Jumputan, merancang dan membuat belah ketupat kemudian menggunting serta menyusunnya kembali menjadi suatu bentuk baru, menentukan luas daerah belah ketupat, membandingkan keliling dua buah kain Jumputan dan menentukan keliling belah ketupat. Subjek penelitian ini adalah 30 siswa kelas VII SMP Pusri Palembang. Penelitian ini menggunakan design research yang terdiri dari tiga tahap : preparing for the experiment, experiment in the classroom (pilot experiment dan  teaching experiment, dan retrospective analysis. Pada tahap preparing for the experiment, beberapa aktifitas dibuat menggunakan pendekatan Pendidikan Matematika Realistik Indonesia (PMRI. Hasil dari penelitian menunjukkan kain Jumputan Palembang dapat digunakan sebagai starting point dalam pembelajaran belah ketupat untuk siswa kelas VII SMP.The design learning rhombus using kain Jumputan Palembang for VII grade students. This research aims to investigate how to use Kain Jumputan Palembang to build student’s understanding on rhombus. Students were required to comparing the area of two cloths, designing and making rhombus then reshaping to new shapes, determining the area of rhombus, comparing the perimeter of two cloths and determining the perimeter of rhombus. Subjects were 30 first grade students of SMP Pusri Palembang. The study used a design research method consisting of three stages : preparing for the experiment, experiment in the classroom (pilot experiment and teaching experiment, and retrospective analysis. During the preparing for the experiment stage, instructional activities was designing utilizing of Indonesian Realistic Mathematics Education (PMRI approach. The result of experiments

  7. Inleiding symposium 'Silent Spring, 50 jaar later'

    NARCIS (Netherlands)

    Lenteren, van J.C.; Hunneman, H.

    2013-01-01

    Een halve eeuw geleden publiceerde Rachel Carson het boek Silent Spring, dat de aandacht vestigde op milieuproblemen en het begin betekende van de milieubeweging. Op zaterdag 17 november 2012 vond in Leiden het symposium ‘Silent Spring, 50 jaar later’ plaats. De Nederlandse Entomologische Vereniging

  8. Nonlinear Vibration of a Magnetic Spring

    Science.gov (United States)

    Zhong, Juhua; Cheng, Zhongqi; Ge, Ziming; Zhang, Yuelan; Lu, Wenqiang; Song, Feng; Li, Chuanyong

    2012-01-01

    To demonstrate the different vibration characteristics of a magnetic spring compared with those of a metal one, a magnetic spring apparatus was constructed from a pair of circular magnets of the same size with an inside diameter of 2.07 cm and an outside diameter of 4.50 cm. To keep the upper magnet in a suspension state, the two magnets were…

  9. 1988 Hanford riverbank springs characterization report

    Energy Technology Data Exchange (ETDEWEB)

    Dirkes, R.L.

    1990-12-01

    This reports presents the results of a special study undertaken to characterize the riverbank springs (i.e., ground-water seepage) entering the Columbia River along the Hanford Site. Radiological and nonradiological analyses were performed. River water samples were also analyzed from upstream and downstream of the Site as well as from the immediate vicinity of the springs. In addition, irrigation return water and spring water entering the river along the shoreline opposite Hanford were analyzed. Hanford-origin contaminants were detected in spring water entering the Columbia River along the Hanford Site. The type and concentrations of contaminants in the spring water were similar to those known to exist in the ground water near the river. The location and extent of the contaminated discharges compared favorably with recent ground-water reports and predictions. Spring discharge volumes remain very small relative to the flow of the Columbia. Downstream river sampling demonstrates the impact of ground-water discharges to be minimal, and negligible in most cases. Radionuclide concentrations were below US Department of Energy Derived Concentration Guides (DCGs) with the exception {sup 90}Sr near the 100-N Area. Tritium, while below the DCG, was detected at concentrations above the US Environmental Protection Agency drinking water standards in several springs. All other radionuclide concentrations were below drinking water standards. Nonradiological contaminants were generally undetectable in the spring water. River water contaminant concentrations, outside of the immediate discharge zones, were below drinking water standards in all cases. 19 refs., 5 figs., 12 tabs.

  10. Environmental evaluation of the PIES Trendlong Mid-Mid Scenario: Federal Region VII

    Energy Technology Data Exchange (ETDEWEB)

    1979-07-01

    Findings of the environmental impact evaluation of the PIES TRENDLONG MID-MID Scenario for Federal Region VII (Iowa, Kansas, Nebraska, and Missouri) are reported. Projected coal-fired utility expansion could be constrained in several areas because of projected TSP and SO/sub 2/ National Ambient Air Quality Standards (NAAQS) violations. Problems will be most pronounced in Iowa and Kansas, but could be incurred in any state in the region. Large coal and nuclear facilities projected for parts of Region VII may experience water availability problems. The Smokey Hill River in Kansas, the Skunk River in Iowa, and the Platte River in Nebraska may have limited water supplies for operating the projected increases in fossil fuel and nuclear generating facilities. Coal surface mining in Missouri (21,000 acres may be disturbed from 1975 to 1990) may create land-use conflicts. Region VII may not have the facilities or legal framework for mitigating the negative socioeconomic impacts that are projected to occur from the proposed energy development. Therefore, the potential for severe and pervasive socioeconomic impacts is great.

  11. Immobilization of 99-Technetium (VII) by Fe(II)-Goethite and Limited Reoxidation

    Energy Technology Data Exchange (ETDEWEB)

    W Um; H Chang; J Icenhower; W Lukens; R Serne; N Qafoku; J Westsik Jr.; E Buck; S Smith

    2011-12-31

    During the nuclear waste vitrification process volatilized {sup 99}Tc will be trapped by melter off-gas scrubbers and then washed out into caustic solutions, and plans are currently being contemplated for the disposal of such secondary waste. Solutions containing pertechnetate [{sup 99}Tc(VII)O{sub 4}{sup -}] were mixed with precipitating goethite and dissolved Fe(II) to determine if an iron (oxy)hydroxide-based waste form can reduce Tc(VII) and isolate Tc(IV) from oxygen. The results of these experiments demonstrate that Fe(II) with goethite efficiently catalyzes the reduction of technetium in deionized water and complex solutions that mimic the chemical composition of caustic waste scrubber media. Identification of the phases, goethite + magnetite, was performed using XRD, SEM and TEM methods. Analyses of the Tc-bearing solid products by XAFS indicate that all of the Tc(VII) was reduced to Tc(IV) and that the latter is incorporated into goethite or magnetite as octahedral Tc(IV). Batch dissolution experiments, conducted under ambient oxidizing conditions for more than 180 days, demonstrated a very limited release of Tc to solution (2-7 {micro}g Tc/g solid). Incorporation of Tc(IV) into the goethite lattice thus provides significant advantages for limiting reoxidation and curtailing release of Tc disposed in nuclear waste repositories.

  12. MENDF71x. Multigroup Neutron Cross Section Data Tables Based upon ENDF/B-VII.1

    Energy Technology Data Exchange (ETDEWEB)

    Conlin, Jeremy Lloyd [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Parsons, Donald Kent [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Gardiner, Steven J. [Univ. of California, Davis, CA (United States); Gray, Mark Girard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Lee, Mary Beth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); White, Morgan Curtis [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-12-17

    A new multi-group neutron cross section library has been released along with the release of NDI version 2.0.20. The library is named MENDF71x and is based upon the evaluations released in ENDF/B-VII.1 which was made publicly available in December 2011. ENDF/B-VII.1 consists of 423 evaluations of which ten are excited states evaluations and 413 are ground state evaluations. MENDF71x was created by processing the 423 evaluations into 618-group, downscatter only NDI data tables. The ENDF/B evaluation files were processed using NJOY version 99.393 with the exception of 35Cl and 233U. Those two isotopes had unique properties that required that we process the evaluation using NJOY version 2012. The MENDF71x library was only processed to room temperature, i.e., 293.6 K. In the future, we plan on producing a multi-temperature library based on ENDF/B-VII.1 and compatible with MENDF71x.

  13. Immobilization of 99-technetium (VII) by Fe(II)-goethite and limited reoxidation.

    Science.gov (United States)

    Um, Wooyong; Chang, Hyun-Shik; Icenhower, Jonathan P; Lukens, Wayne W; Serne, R Jeffrey; Qafoku, Nikolla P; Westsik, Joseph H; Buck, Edgar C; Smith, Steven C

    2011-06-01

    During the nuclear waste vitrification process volatilized (99)Tc will be trapped by melter off-gas scrubbers and then washed out into caustic solutions, and plans are currently being contemplated for the disposal of such secondary waste. Solutions containing pertechnetate [(99)Tc(VII)O(4)(-)] were mixed with precipitating goethite and dissolved Fe(II) to determine if an iron (oxy)hydroxide-based waste form can reduce Tc(VII) and isolate Tc(IV) from oxygen. The results of these experiments demonstrate that Fe(II) with goethite efficiently catalyzes the reduction of technetium in deionized water and complex solutions that mimic the chemical composition of caustic waste scrubber media. Identification of the phases, goethite + magnetite, was performed using XRD, SEM and TEM methods. Analyses of the Tc-bearing solid products by XAFS indicate that all of the Tc(VII) was reduced to Tc(IV) and that the latter is incorporated into goethite or magnetite as octahedral Tc(IV). Batch dissolution experiments, conducted under ambient oxidizing conditions for more than 180 days, demonstrated a very limited release of Tc to solution (2-7 μg Tc/g solid). Incorporation of Tc(IV) into the goethite lattice thus provides significant advantages for limiting reoxidation and curtailing release of Tc disposed in nuclear waste repositories.

  14. Human type VII collagen: cDNA cloning and chromosomal mapping of the gene

    Energy Technology Data Exchange (ETDEWEB)

    Parente, M.G.; Chung, L.C.; Ryynaenen, J.; Monli Chu; Uitto, J. (Thomas Jefferson Univ., Philadelphia, PA (United States)); Woodley, D.T.; Wynn, K.C.; Bauer, E.A. (Stanford Univ., CA (United States)); Mattei, M.G. (Institute National de la Sante et de la Recherche Medicale, Marseille (France))

    1991-08-15

    A human keratinocyte cDNA expression library in bacteriophage {lambda}gt11 was screened with the purified IgG fraction of serum from a patient with epidermolysis bullosa acquisita, which had a high titer of anti-type VII collagen antibodies. Screening of {approx}3 {times} 10{sup 5} plaques identified 8 positive clones, the largest one (K-131) being {approx}1.9 kilobases in size. Dideoxynucleotide sequencing of K-131 indicated that it consisted of 1875 base pairs and contained an open reading frame coding for a putative N-terminal noncollagenous domain of 439 amino acids and a collagenous domain was characterized by repeating Gly-Xaa-Yaa sequences that were interrupted in several positions by insertions or deletions of 1-3 amino acids. The deduced amino acid sequence also revealed a peptide segment that had a high degree of identity with a published type VII collagen protein sequence. The results mapped the COL7A1 to the locus 3p21. The cDNA clones characterized in this study will be valuable for understanding the protein structure and gene expression of type VII collagen present in anchoring fibrils and its aberrations in the dystrophic forms of heritable epidermolysis bullosa.

  15. Weldon Spring historical dose estimate

    Energy Technology Data Exchange (ETDEWEB)

    Meshkov, N.; Benioff, P.; Wang, J.; Yuan, Y.

    1986-07-01

    This study was conducted to determine the estimated radiation doses that individuals in five nearby population groups and the general population in the surrounding area may have received as a consequence of activities at a uranium processing plant in Weldon Spring, Missouri. The study is retrospective and encompasses plant operations (1957-1966), cleanup (1967-1969), and maintenance (1969-1982). The dose estimates for members of the nearby population groups are as follows. Of the three periods considered, the largest doses to the general population in the surrounding area would have occurred during the plant operations period (1957-1966). Dose estimates for the cleanup (1967-1969) and maintenance (1969-1982) periods are negligible in comparison. Based on the monitoring data, if there was a person residing continually in a dwelling 1.2 km (0.75 mi) north of the plant, this person is estimated to have received an average of about 96 mrem/yr (ranging from 50 to 160 mrem/yr) above background during plant operations, whereas the dose to a nearby resident during later years is estimated to have been about 0.4 mrem/yr during cleanup and about 0.2 mrem/yr during the maintenance period. These values may be compared with the background dose in Missouri of 120 mrem/yr.

  16. Contamination monitoring and control on ASML MS-VII 157-nm exposure tool

    Science.gov (United States)

    Okoroanyanwu, Uzodinma; Gronheid, Roel; Coenen, Jan; Hermans, Jan; Ronse, Kurt G.

    2004-05-01

    This paper presents results of monitoring and control of contaminants in an ASML MS-VII 157nm full-field exposure tool at IMEC, as verified lithographically in terms of field uniformity, lens transmission, CD uniformity, and scattered light. The daily contamination monitoring system utilizes in-line photo-ionization detector, oxygen and moisture analyzers, as well as chemiluminescent detector, and gas chromatograph that is coupled to a mass spectrometer. On a monthly basis, contamination monitoring was performed with thermal desorption-gas chromatographi/mass spectrometric techniques. The following four locations within the optical path of the MS-VII are monitored: source optic assembly, condenser lens optic, 1X relay station, and projection optics box. Contamination control is realized in the system with an on-board purge control unit, which is equipped with gas purifiers that remove contaminants such as H2O, O2, CO, CO2, hydrocarbons, H2, and sulfur compounds. All the observed contaminants have been trending within expected values and no contamination-related tool performance degradation has been observed. The excursions observed in the contaminant concentrations are coincident with tool downtime/maintenance events. Siloxane levels appear to be consistently below 50 ppt in all the monitored locations within the optical path of the tool, except on one occasion when it reached 90 ppt in the projection optics. Volatile organic compounds (VOCs) concentration within the MS-VII enclosure show a stable background level of around 10-25 ppb during weekends and levels of 45-60 ppb (during working days). VOCs concentration variations inside the MS-VII enclosure during the working days correlate well with activities inside the clean room. Air recirculation and low intake of fresh air inside the MS-VII tend to slow down the speed with which the VOCs levels decreases to stable background level, whenever there was a major upward excursion in their concentration. Average light

  17. Spring/dimple instrument tube restraint

    Science.gov (United States)

    DeMario, Edmund E.; Lawson, Charles N.

    1993-01-01

    A nuclear fuel assembly for a pressurized water nuclear reactor has a spring and dimple structure formed in a non-radioactive insert tube placed in the top of a sensor receiving instrumentation tube thimble disposed in the fuel assembly and attached at a top nozzle, a bottom nozzle, and intermediate grids. The instrumentation tube thimble is open at the top, where the sensor or its connection extends through the cooling water for coupling to a sensor signal processor. The spring and dimple insert tube is mounted within the instrumentation tube thimble and extends downwardly adjacent the top. The springs and dimples restrain the sensor and its connections against lateral displacement causing impact with the instrumentation tube thimble due to the strong axial flow of cooling water. The instrumentation tube has a stainless steel outer sleeve and a zirconium alloy inner sleeve below the insert tube adjacent the top. The insert tube is relatively non-radioactivated inconel alloy. The opposed springs and dimples are formed on diametrically opposite inner walls of the insert tube, the springs being formed as spaced axial cuts in the insert tube, with a web of the insert tube between the cuts bowed radially inwardly for forming the spring, and the dimples being formed as radially inward protrusions opposed to the springs.

  18. Hydrogeologic assessment—Figeh Spring, Damascus, Syria

    Science.gov (United States)

    Lamoreaux, P. E.; Hughes, Travis H.; Memon, Bashir A.; Lineback, Neal

    1989-03-01

    Hydrogeological studies at Figeh Springs were directed to determine groundwater flow paths, research, storage and discharge units, and the maximum reliable yield. The project was designed to provide information upon which to base pumpage to augment low-season flows from the spring which is the major water supply for the city of Damascus, Syria. As a basis for conclusions and recommendations, work included extensive surface geologic mapping, air photographic interpretation, a detailed well and spring inventory, and a quality of water sampling program. Geologic structural work included mapping and jointing, faulting, and folding, and an analysis of their impact on groundwater movement.

  19. Executive summary: Weldon Spring Site Environmental Report for calendar year 1992. Weldon Spring Site Remedial Action Project, Weldon Spring, Missouri

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    This report has been prepared to provide information about the public safety and environmental protection programs conducted by the Weldon Spring Site Remedial Action Project. The Weldon Spring site is located in southern St. Charles County, Missouri, approximately 48 km (30 mi) west of St. Louis. The site consists of two main areas, the Weldon Spring Chemical Plant and raffinate pits and the Weldon Spring Quarry. The objectives of the Site Environmental Report are to present a summary of data from the environmental monitoring program, to characterize trends and environmental conditions at the site, and to confirm compliance with environmental and health protection standards and requirements. The report also presents the status of remedial activities and the results of monitoring these activities to assess their impacts on the public and environment. The scope of the environmental monitoring program at the Weldon Spring site has changed since it was initiated. Previously, the program focused on investigations of the extent and level of contaminants in the groundwater, surface waters, buildings, and air at the site. In 1992, the level of remedial activities required monitoring for potential impacts of those activities, particularly on surface water runoff and airborne effluents. This report includes monitoring data from routine radiological and nonradiological sampling activities. These data include estimates of dose to the public from the Weldon Spring site; estimates of effluent releases; and trends in groundwater contaminant levels. Also, applicable compliance requirements, quality assurance programs, and special studies conducted in 1992 to support environmental protection programs are reviewed.

  20. Conserved Water-mediated Hydrogen Bond Network between TM-I, -II, -VI, and -VII in 7TM Receptor Activation*

    Science.gov (United States)

    Nygaard, Rie; Valentin-Hansen, Louise; Mokrosinski, Jacek; Frimurer, Thomas M.; Schwartz, Thue W.

    2010-01-01

    Five highly conserved polar residues connected by a number of structural water molecules together with two rotamer micro-switches, TrpVI:13 and TyrVII:20, constitute an extended hydrogen bond network between the intracellular segments of TM-I, -II, -VI, and -VII of 7TM receptors. Molecular dynamics simulations showed that, although the fewer water molecules in rhodopsin were relatively movable, the hydrogen bond network of the β2-adrenergic receptor was fully loaded with water molecules that were surprisingly immobilized between the two rotamer switches, both apparently being in their closed conformation. Manipulations of the rotamer state of TyrVII:20 and TrpVI:13 demonstrated that these residues served as gates for the water molecules at the intracellular and extracellular ends of the hydrogen bond network, respectively. TrpVI:13 at the bottom of the main ligand-binding pocket was shown to apparently function as a catching trap for water molecules. Mutational analysis of the β2-adrenergic receptor demonstrated that the highly conserved polar residues of the hydrogen bond network were all important for receptor signaling but served different functions, some dampening constitutive activity (AsnI:18, AspII:10, and AsnVII:13), whereas others (AsnVII:12 and AsnVII:16) located one helical turn apart and sharing a water molecule were shown to be essential for agonist-induced signaling. It is concluded that the conserved water hydrogen bond network of 7TM receptors constitutes an extended allosteric interface between the transmembrane segments being of crucial importance for receptor signaling and that part of the function of the rotamer micro-switches, TyrVII:20 and TrpVI:13, is to gate or trap the water molecules. PMID:20395291

  1. Process for Forming a High Temperature Single Crystal Canted Spring

    Science.gov (United States)

    DeMange, Jeffrey J (Inventor); Ritzert, Frank J (Inventor); Nathal, Michael V (Inventor); Dunlap, Patrick H (Inventor); Steinetz, Bruce M (Inventor)

    2017-01-01

    A process for forming a high temperature single crystal canted spring is provided. In one embodiment, the process includes fabricating configurations of a rapid prototype spring to fabricate a sacrificial mold pattern to create a ceramic mold and casting a canted coiled spring to form at least one canted coil spring configuration based on the ceramic mold. The high temperature single crystal canted spring is formed from a nickel-based alloy containing rhenium using the at least one coil spring configuration.

  2. Resultados neonatais no parto vaginal espontâneo comparados aos dos partos com fórcipe de Simpson-Braun em primíparas Neonatal outcome of spontaneous deliveries as compared to Simpson-Braun forceps deliveries in nulliparous women

    Directory of Open Access Journals (Sweden)

    Belmiro Gonçalves Pereira

    2004-02-01

    Full Text Available OBJETIVO: comparar os resultados neonatais dos partos vaginais espontâneos ou assistidos com fórcipe de Simpson-Braun em nulíparas. MÉTODO: em estudo de corte retrospectivo foram avaliados dois grupos de primíparas atendidas no Centro Obstétrico do CAISM/UNICAMP, que tiveram parto vaginal sob analgesia epidural. O grupo fórcipe foi formado por 119 pacientes que tiveram parto a fórcipe de Simpson-Braun, e o grupo normal por 114 casos de parto vaginal espontâneo. Foram estudadas as variáveis neonatais imediatas como o estado do líquido amniótico e os índices de Apgar, assim como a evolução neonatal nos primeiros dias de vida. Para análise estatística foram utilizados os testes c², exato de Fisher e t de Student para comparação de médias e considerada significativa a diferença correspondente a pPURPOSE: to compare maternal and neonatal outcomes between spontaneous vaginal and Simpson-Braun forceps deliveries in nulliparous women. METHOD: a retrospective study including two groups of nulliparous women, who had vaginal delivery under peridural anesthesia in the obstetric unit of the CAISM-UNICAMP: the forceps group included 119 women who had Simpson-Braun forceps delivery, and the normal group included 114 women who delivered spontaneously. Neonatal outcomes, such as Apgar score and the evolution in the first days of life, were studied. Data were compared in both groups and, for statistical analysis, c² test, Fisher exact, and Student t tests were used. The differences were considered significant when p<0.05. RESULTS: the indications for Simpson-Braun forceps delivery were maternal-fetal relief (90 cases and abbreviation of the expulsive period (29 cases. In the forceps group there were 8 cases (6.7% of vaginal injuries; a similar result was observed in the normal group. The number of hospitalization days for the parturient and the newborns was identical, 2.4 days. The newborns in the two groups had similar Apgar scores

  3. Fish Springs pond snail : Refuge communication scenario

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Communication scenario between the branch of Listing and Recovery, Fish and Wildlife Enhancement, and Fish Springs National Wildlife Refuge (NWR), in regards to the...

  4. Fish Springs National Wildlife Refuge habitat map

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Habitat map for Fish Springs National Wildlife Refuge. This habitat map was created along with the National Vegetation Classification (NVC) map of the refuge. Refuge...

  5. Pagosa Springs geothermal project. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    1984-10-19

    This booklet discusses some ideas and methods for using Colorado geothermal energy. A project installed in Pagosa Springs, which consists of a pipeline laid down 8th street with service to residences retrofitted to geothermal space heating, is described. (ACR)

  6. Stravinsky: The Rite of Spring. Canticum sacrum

    Index Scriptorium Estoniae

    1996-01-01

    Uuest heliplaadist "Stravinsky: The Rite of Spring. Canticum sacrum. Requiem canticles. Choral Variations on "Vom Himmel hoch". Lausanne Pro Arte Choir, Suisse Romande Chamber Choir and Orchestra, Neeme Järvi" Chandos CHAN 9408 (75 minutes:DDD)

  7. SPring-8 and application of nuclear scattering

    Energy Technology Data Exchange (ETDEWEB)

    Harami, Taikan [Japan Atomic Energy Research Inst., Kamigori, Hyogo (Japan). Kansai Research Establishment

    1997-03-01

    The SPring-8 has Linac synchrotron, incidence type facility and an accumulation ring. By preparing a beam line to take out light at the accumulation ring, the SPring-8 is supplied for common applications. Development of science adopting new method to study of properties and organisms by using high brightness source is expected. Construction of the SPring-8 accelerator was finished and adjusting test and commissioning of apparatuses are now in proceeding. At pre-use inspection of the accumulation ring on March, 1997, beam lines for R and D and crystalline structure analysis are applied to the Science and Technology Agency to inspect them simultaneously. And, by activating character of the SPring-8 radiation facility of high brightness and high energy X-ray generator, property study using Moessbauer nuclide to a probe can be conducted. (G.K.)

  8. Inleiding symposium 'Silent Spring, 50 jaar later'

    OpenAIRE

    Lenteren, van, J.C.; Hunneman, H.

    2013-01-01

    Een halve eeuw geleden publiceerde Rachel Carson het boek Silent Spring, dat de aandacht vestigde op milieuproblemen en het begin betekende van de milieubeweging. Op zaterdag 17 november 2012 vond in Leiden het symposium ‘Silent Spring, 50 jaar later’ plaats. De Nederlandse Entomologische Vereniging (NEV) organiseerde deze dag met medewerking van de Uyttenboogaart-Eliasen Stichting, De Vlinderstichting, Stichting Natuur en Milieu, Vereniging Natuurmonumenten en de Faunabescherming. Het was ee...

  9. The Affective Legacy of Silent Spring

    OpenAIRE

    Alex Lockwood

    2012-01-01

    In the fiftieth year since the publication of Silent Spring, the importance of Rachel Carson’s work can be measured in its affective influence on contemporary environmental writing across the humanities. The ground broken by Silent Spring in creating new forms of writing has placed affect at the very centre of contemporary narratives that call for pro-environmental beliefs and behaviours. A critical public-feelings framework is used to explore these issues and trace their passage from the pri...

  10. The diagnosis of pelvic fractures by 'springing'.

    OpenAIRE

    Grant, P. T.

    1990-01-01

    Thirty-six patients were studied prospectively to assess the benefit of 'springing' the pelvis in traumatized patients, to confirm or refute a fracture of the pelvis. None of the patients was multiply injured and half of those with fractures were elderly, sustaining their injuries in simple falls. Springing the pelvis was a poor predictor of the presence or absence of a pelvic fracture, at best it yielded a specificity of 71% and sensitivity of 59%. Its routine use in clinical examination sho...

  11. How sick is the Spring AGU Meeting?

    Science.gov (United States)

    Goff, John A.

    I confess—I missed Spring AGU this year. But who can be surprised? After all, I am in the Tectonophysics Section, and almost none of us showed up.Recently skimming the Spring 2000 AGU abstract volume, I was stunned to see that the Tectonophysics abstracts constituted only a bit more than twelve pages—slightly less than Geomagnetism and Paleomagnetism, and a touch more than Geodesy. What has become of us?

  12. T and B cells target identical regions of the non-collagenous domain 1 of type VII collagen in epidermolysis bullosa acquisita.

    Science.gov (United States)

    Müller, Ralf; Dahler, Christiane; Möbs, Christian; Wenzel, Elke; Eming, Rüdiger; Messer, Gerald; Niedermeier, Andrea; Hertl, Michael

    2010-04-01

    Epidermolysis bullosa acquisita (EBA) is a severe immunobullous disease and is caused by IgG against type VII collagen (Col VII) of anchoring fibrils. In this study, utilizing ELISA and immunoblot, 13/15 EBA sera but 0/20 bullous pemphigoid sera and 0/30 healthy control sera showed IgG reactivity with distinct recombinant subregions of the non-collagenous domain 1 (NC1) of Col VII. In two EBA patients, IgG titers against Col VII-NC1 were grossly correlated to clinical disease activity. Moreover, Col VII-reactive T cells were identified in a representative EBA patient which recognized identical subdomains of Col VII-NC1. These findings strongly suggest that (1) the Col VII-NC1 ELISA is a powerful tool for making the diagnosis of EBA, (2) Col VII-specific IgG grossly relates to disease activity and (3) IgG reactivity is associated with T cell recognition of identical subdomains of Col VII-NC1. Copyright 2009 Elsevier Inc. All rights reserved.

  13. Water quality modelling of Jadro spring.

    Science.gov (United States)

    Margeta, J; Fistanic, I

    2004-01-01

    Management of water quality in karst is a specific problem. Water generally moves very fast by infiltration processes but far more by concentrated flows through fissures and openings in karst. This enables the entire surface pollution to be transferred fast and without filtration into groundwater springs. A typical example is the Jadro spring. Changes in water quality at the spring are sudden, but short. Turbidity as a major water quality problem for the karst springs regularly exceeds allowable standards. Former practice in problem solving has been reduced to intensive water disinfection in periods of great turbidity without analyses of disinfection by-products risks for water users. The main prerequisite for water quality control and an optimization of water disinfection is the knowledge of raw water quality and nature of occurrence. The analysis of monitoring data and their functional relationship with hydrological parameters enables establishment of a stochastic model that will help obtain better information on turbidity in different periods of the year. Using the model a great number of average monthly and extreme daily values are generated. By statistical analyses of these data possibility of occurrence of high turbidity in certain months is obtained. This information can be used for designing expert system for water quality management of karst springs. Thus, the time series model becomes a valuable tool in management of drinking water quality of the Jadro spring.

  14. PENGEMBANGAN LKS BERBASIS PROJECT BASED LEARNING UNTUK PEMBELAJARAN MATERI SEGITIGA DI KELAS VII

    Directory of Open Access Journals (Sweden)

    Dian Novita

    2016-06-01

    Full Text Available Penelitian ini merupakan penelitian pengembangan yang bertujuan untuk (1mengetahui karakteristik LKS berbasis Project Based Learning (PjBL yang valid dan praktis dalam pembelajaran materi segitiga di kelas VII; (2mengetahui efek potensial penggunaan LKS berbasis PjBL terhadap hasil belajar siswa dalam pembelajaran materi segitiga di kelas VII. Metode penelitian pengembangan yang digunakan adalah model  ADDIE (Analysis, Design, Development, Implementation, and Evaluation. Teknik pengumpulan data yang digunakan adalah walkthrough, tes hasil belajar dan angket. Dari tes hasil belajar, diperoleh bahwa sebesar 82,5% siswa telah mencapai kategori tuntas dan 17,5% belum tuntas dengan KKM 75. Hasil angket respon siswa menunjukkan bahwa untuk pelaksanaan pembelajaran menggunakan LKS berbasis PjBL telah mencapai kriteria kepraktisan. Kemudian untuk LKS berbasis PjBL yang telah didesain, divalidasi oleh beberapa pakar, kemudian direvisi berdasarkan saran dari para pakar tersebut. LKS yang telah direvisi tersebut dianggap telah memenuhi kriteria kevalidan dan kepraktisan sehingga dapat digunakan dalam pembelajaran materi segitiga di kelas VII. Kesimpulan dari penelitian ini adalah (1 LKS bebasis PjBL yang dikembangkan valid, tergambar dari konten (sesuai dengan kurikulum untuk materi segitiga, konstruk (sesuai dengan prinsip PjBL, dan bahasa (sesuai dengan ejaan yang disempurnakan (EYD. Kepraktisan tergambar dari proses kerja siswa dalam melaksanakan LKS dan hasil angket respon siswa terhadap pembelajaran menggunakan LKS berbasis PjBL; (2 dari hasil latihan yang dikerjakan oleh siswa, LKS berbasis PjBL memiliki efek potensial terhadap hasil belajar, yakni sebanyak 33 siswa termasuk kategori tuntas (82,5% dan 7 orang belum tuntas (17,5%, dengan KKM 75. Kata Kunci : LKS, Project Based Learning DOI: http://dx.doi.org/10.22342/jpm.10.2.3626.1-12

  15. Electron Impact Excitation Collision Strengths for Extreme Ultraviolet Lines of Fe VII and Fe IX

    Science.gov (United States)

    Tayal, Swaraj S.; Zatsarinny, Oleg

    2014-08-01

    Extensive calculations are performed for electron excitation collision strengths and transitions probabilities for a wide range of ultraviolet lines in Fe VII and Fe IX. The collision strengths are calculated in the close-coupling approximation using the B-spline Breit-Pauli R-matrix method. The multiconfiguration Hartree-Fock method in conjunction with B-spline expansions is employed for an accurate representation of the target wave-functions. The close-coupling expansions include 189 and 370 fine-structure levels of Fe VII and Fe IX respectively. We have included levels of the 3p6, 3p53d,4l,5s, 3s3p63d,4s,4p, 3p43d2, 3s3p53d2 configurations and some low-lying levels of the 3p33d3 configuration for Fe IX. The effective collision strengths are obtained by averaging the electron collision strengths over a Maxwellian distribution of velocities at electron temperatures in the range from 104 to 107 K. There is a good agreement with the previous R-matrix calculation for transitions between first 17 levels of the 3p6, 3p53d, and 3s3p63d configurations in Fe IX. We were able to generate more accurate target states than those in the previous calculations. We included all 3p43d3nl correlation configurations and 3p-4f promotion for Fe VII which were found very important for accurate representation of 3dnl states. The present results considerably expand the existing data sets for Fe IX, allowing a more detailed treatment of the available measured spectra from different space observatories.This research work is supported by NASA grant NNX11AB62G from the Solar and Heliophysics program.

  16. Optimizing Cr(VI) and Tc(VII) remediation through nano-scale biomineral engineering

    Energy Technology Data Exchange (ETDEWEB)

    Cutting, R. S.; Coker, V. S.; Telling, N. D.; Kimber, R. L.; Pearce, C. I.; Ellis, B.; Lawson, R; van der Laan, G.; Pattrick, R.A.D.; Vaughan, D.J.; Arenholz, E.; Lloyd, J. R.

    2009-09-09

    To optimize the production of biomagnetite for the bioremediation of metal oxyanion contaminated waters, the reduction of aqueous Cr(VI) to Cr(III) by two biogenic magnetites and a synthetic magnetite was evaluated under batch and continuous flow conditions. Results indicate that nano-scale biogenic magnetite produced by incubating synthetic schwertmannite powder in cell suspensions of Geobacter sulfurreducens is more efficient at reducing Cr(VI) than either biogenic nano-magnetite produced from a suspension of ferrihydrite 'gel' or synthetic nano-scale Fe{sub 3}O{sub 4} powder. Although X-ray Photoelectron Spectroscopy (XPS) measurements obtained from post-exposure magnetite samples reveal that both Cr(III) and Cr(VI) are associated with nanoparticle surfaces, X-ray Magnetic Circular Dichroism (XMCD) studies indicate that some Cr(III) has replaced octahedrally coordinated Fe in the lattice of the magnetite. Inductively Coupled Plasma-Atomic Emission Spectrometry (ICP-AES) measurements of total aqueous Cr in the associated solution phase indicated that, although the majority of Cr(III) was incorporated within or adsorbed to the magnetite samples, a proportion ({approx}10-15 %) was released back into solution. Studies of Tc(VII) uptake by magnetites produced via the different synthesis routes also revealed significant differences between them as regards effectiveness for remediation. In addition, column studies using a {gamma}-camera to obtain real time images of a {sup 99m}Tc(VII) radiotracer were performed to visualize directly the relative performances of the magnetite sorbents against ultra-trace concentrations of metal oxyanion contaminants. Again, the magnetite produced from schwertmannite proved capable of retaining more ({approx}20%) {sup 99m}Tc(VII) than the magnetite produced from ferrihydrite, confirming that biomagnetite production for efficient environmental remediation can be fine-tuned through careful selection of the initial Fe(III) mineral

  17. Tissue factor is an angiogenic-specific receptor for factor VII-targeted immunotherapy and photodynamic therapy.

    Science.gov (United States)

    Hu, Zhiwei; Cheng, Jijun; Xu, Jie; Ruf, Wolfram; Lockwood, Charles J

    2017-02-01

    Identification of target molecules specific for angiogenic vascular endothelial cells (VEC), the inner layer of pathological neovasculature, is critical for discovery and development of neovascular-targeting therapy for angiogenesis-dependent human diseases, notably cancer, macular degeneration and endometriosis, in which vascular endothelial growth factor (VEGF) plays a central pathophysiological role. Using VEGF-stimulated vascular endothelial cells (VECs) isolated from microvessels, venous and arterial blood vessels as in vitro angiogenic models and unstimulated VECs as a quiescent VEC model, we examined the expression of tissue factor (TF), a membrane-bound receptor on the angiogenic VEC models compared with quiescent VEC controls. We found that TF is specifically expressed on angiogenic VECs in a time-dependent manner in microvessels, venous and arterial vessels. TF-targeted therapeutic agents, including factor VII (fVII)-IgG1 Fc and fVII-conjugated photosensitizer, can selectively bind angiogenic VECs, but not the quiescent VECs. Moreover, fVII-targeted photodynamic therapy can selectively and completely eradicate angiogenic VECs. We conclude that TF is an angiogenic-specific receptor and the target molecule for fVII-targeted therapeutics. This study supports clinical trials of TF-targeted therapeutics for the treatment of angiogenesis-dependent diseases such as cancer, macular degeneration and endometriosis.

  18. Reimagining King and Country: the return of Ferdinand VII and the agony of Liberalism

    OpenAIRE

    Gonzalo Butrón Prida

    2014-01-01

    This paper analyzes, mainly drawing on the Liberal press, the political options put forward in the early months of 1814 on the occasion of the Valençay treaty and the return of Ferdinand VII to Spain. The political atmosphere of uncertainty generated by the King’s silence allowed for the incorporation of moderate alternatives to the political debate. Thus, besides the two more popular options, associated with the 1812 Constitution and the absolute regime emerged as a result of the Mutiny of A...

  19. AMADIS 2014. VII Congreso de Accesibilidad a los Medios Audiovisuales para Personas con Discapacidad

    OpenAIRE

    Varios Autores

    2015-01-01

    Celebrado los días 13 y 14 de noviembre de 2014, en el Instituto de la Corporación de Radio Televisión Española, el VII Congreso AMADIS ha convocado una vez más a los principales responsables públicos implicados en la accesibilidad audiovisual, a las empresas que proporcionan servicios, al movimiento asociativo, a los investigadores y a los usuarios de estas actividades culturales. En esta edición, los debates se centraron en las distintas vertientes de la accesibilidad a la televisión como ...

  20. Underground Test Area Subproject Phase I Data Analysis Task. Volume VII - Tritium Transport Model Documentation Package

    Energy Technology Data Exchange (ETDEWEB)

    None

    1996-12-01

    Volume VII of the documentation for the Phase I Data Analysis Task performed in support of the current Regional Flow Model, Transport Model, and Risk Assessment for the Nevada Test Site Underground Test Area Subproject contains the tritium transport model documentation. Because of the size and complexity of the model area, a considerable quantity of data was collected and analyzed in support of the modeling efforts. The data analysis task was consequently broken into eight subtasks, and descriptions of each subtask's activities are contained in one of the eight volumes that comprise the Phase I Data Analysis Documentation.

  1. Hormone therapy affects plasma measures of factor VII-activating protease in younger postmenopausal women

    DEFF Research Database (Denmark)

    Mathiasen, Jørn Sidelmann; Skouby, S.O.; Vitzthum, F.

    2010-01-01

    Objectives Current reviews indicate that hormone therapy (HT) has a protective role in coronary heart disease (CHD) in younger postmenopausal women, whereas HT contributes to CHD in older women Factor VII-activating protease (FSAP) is a serine protease that accumulates in unstable atherosclerotic...... measures of FSAP in postmenopausal women treated for I year with different HT formulations or no HT. Methods Six groups of postmenopausal women (n = 139) were allocated to five different HT modalities or no HT Samples were collected at baseline and after 12 months of treatment. Prototype assays were used...... in younger postmenopausal women...

  2. Pervivencia de los Tristia de Ovidio en la Antigüedad (ssI-VII)

    OpenAIRE

    Baeza Angulo, Eulogio

    1995-01-01

    El presente artículo persigue un doble objetivo. En primer lugar, mostrar en conjunto cuál ha sido la influencia y pervivencia de los Tristia de Ovidio hasta el siglo vii d. C. Y, en segundo lugar, que, aunque existen ciertos ecos de esta obra, sin embargo su pervivencia ha sido prácticamente testimonial frente a la gran influencia ejercida por las Metamorfosis y la obra elegíacoamatoria. The aim of this essay is a double one. First of alt, it is aimed at showing dic influen...

  3. Aspectos literarios de la obra de don Joan de Castellanos : Capítulo VII

    Directory of Open Access Journals (Sweden)

    Mario Germán Romero

    1966-02-01

    Full Text Available Capitulo VII. Los discursos de Colón Es sabido que los escritores antiguos; principalmente los historiógrafos, introducían supuestos discursos en sus obras. Salustio consigna cuatro en sus Historias. Tito Livio los elabora con perfección y los pone en boca de políticos y generales importantes; en los treinta y cinco libros que se conservan de este autor encontramos unos cuatrocientos discursos, breves o extensos, que como los de Salustio fueron recopilados y editados para fines retóricos.

  4. Grotrian diagrams for highly ionized iron Fe VII through Fe XXVI

    Energy Technology Data Exchange (ETDEWEB)

    Shirai, Toshizo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Sugar, J.; Wiese, W.L.

    1997-07-01

    Grotrian diagrams are presented to provide graphical overviews for 2,201 spectral lines of highly ionized iron, Fe VII through Fe XXVI. In the usual diagram display such as that by Bashkin and Stoner (North-Holland, Amsterdam, 1975), the density of transitions is often too high to allow each transition to be drawn separately. Here in our modified diagrams, the transitions are also represented by lines connecting the upper and lower energy levels, but the lower energy levels are extended and repeated for successive configurations as needed. As a sequence, dense packing is avoided and all lines in a multiplet can be accommodated. (author)

  5. Eksplorasi dan Pengamatan Intensitas Serangan Hama Penting Tanaman Tebu di PTPN VII, Cinta Manis Sumatera Selatan

    Directory of Open Access Journals (Sweden)

    Dewi Meidalima

    2015-03-01

    Full Text Available Penelitian bertujunan mengamati serangga-serangga hama penting yang menyerang tanaman tebu di PTPN VII, Cinta Manis Sumatera Selatan, dilakukan dari bulan Februari sampai September 2012. Metode survei langsung ke pertanaman dengan mengikuti jadual early warning system (EWS PTPN VII. Hasil penelitian menemukan serangga hama penting tanaman tebu ialah penggerek batang bergaris (Chilo saccharipaghus, penggerek batang berkilat (Chilo auricilius, dan penggerek pucuk (Scirpophaga nivella. Gejala serangan penggerek batang dan pucuk tebu ditemukanpada umur 2 bulan, serangan tinggi pada umur 3-5 bulan, hal ini berkaitan dengan cuaca. Pada saat penelitian dilakukan serangan tertinggi terjadi pada bulan Mei sampai Juli, dengan suhu, curah hujan, jumlah hari hujan, dan kelembaban nisbi berturut-turut adalah 26,6OC, 245,5 mm, 17 hari dan 98%. Serangan pada tanaman muda, menyebabkan kematian. Pada tanaman yang sudah membentuk ruas, gejala penggerek batang jelas terlihat dari luar jika daun tebu “diklentek”. Gejala serangan penggerek pucuk terlihat pada helai daun yang berlubang.Intensitas serangan penggerek batang tertinggi pada umur tebu 3 bulan (6,69%, sedangkan intensitas serangan (2,97% dan populasi penggerek pucuk (44,60 larva tertinggi pada umur 3,5 bulan. The research aimed to observe the important pest insects attacking sugarcane in PTPN VII, Cinta Manis,South Sumatra. Direct Survey methodto the crop by following the schedule ofearly warning system (EWS of PTPN VII, conducted from February to September 2012. The results found that important insect pests attacking sugarcane werestriped stem borer (Chilo saccharipaghus, shiny stem borer (Chilo auricilius, and shoot borers (Scirpophaga nivella. Symptoms attack of shotand stemborer of sugarcane were found at 2 months of sugarcane age, high attack at the age of 3-5 months, it is highly related to weather.The highest attack occurred in May and July, with the temperature, precipitation, number of rainy

  6. The source, discharge, and chemical characteristics of water from Agua Caliente Spring, Palm Springs, California

    Science.gov (United States)

    Contributors: Brandt, Justin; Catchings, Rufus D.; Christensen, Allen H.; Flint, Alan L.; Gandhok, Gini; Goldman, Mark R.; Halford, Keith J.; Langenheim, V.E.; Martin, Peter; Rymer, Michael J.; Schroeder, Roy A.; Smith, Gregory A.; Sneed, Michelle; Martin, Peter

    2011-01-01

    Agua Caliente Spring, in downtown Palm Springs, California, has been used for recreation and medicinal therapy for hundreds of years and currently (2008) is the source of hot water for the Spa Resort owned by the Agua Caliente Band of the Cahuilla Indians. The Agua Caliente Spring is located about 1,500 feet east of the eastern front of the San Jacinto Mountains on the southeast-sloping alluvial plain of the Coachella Valley. The objectives of this study were to (1) define the geologic structure associated with the Agua Caliente Spring; (2) define the source(s), and possibly the age(s), of water discharged by the spring; (3) ascertain the seasonal and longer-term variability of the natural discharge, water temperature, and chemical characteristics of the spring water; (4) evaluate whether water-level declines in the regional aquifer will influence the temperature of the spring discharge; and, (5) estimate the quantity of spring water that leaks out of the water-collector tank at the spring orifice.

  7. Spring break versus spring broken: predictive utility of spring break alcohol intentions and willingness at varying levels of extremity.

    Science.gov (United States)

    Litt, Dana M; Lewis, Melissa A; Patrick, Megan E; Rodriguez, Lindsey; Neighbors, Clayton; Kaysen, Debra L

    2014-02-01

    Within the domain of risk-related behavior, many times the decision to engage is not a product of premeditation or intention. The prototype willingness model was created to capture and explain the unintended element of risk behavior. The present study aimed to evaluate the importance of willingness versus intention, two important constructs within the prototype willingness model, in relation to spring break drinking behavior when assessed at both high and low extremities. College undergraduates (N = 275) completed questionnaires prior to spring break regarding their anticipated spring break activities. Willingness and intention were assessed for different levels of risk. Specifically, participants indicated the extent to which they intended to (a) get drunk and (b) drink enough to black out or pass out; and the extent to which they were willing to (a) get drunk and (b) drink enough to black out or pass out. When classes resumed following spring break, the students indicated the extent to which they actually (a) got drunk and (b) drank enough to black out or pass out. Results demonstrated that when the health-related risk was lower (i.e., getting drunk), intention was a stronger predictor of behavior than was willingness. However, as the level of risk increased (i.e., getting drunk enough to black out or pass out), willingness more strongly predicted behavior. The present study suggests that willingness and intentions differentially predict spring break alcohol-related behavior depending on the extremity of behavior in question. Implications regarding alcohol interventions are discussed.

  8. Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation

    DEFF Research Database (Denmark)

    Nygaard, Rie; Hansen, Louise Valentin; Mokrosinski, Jacek

    2010-01-01

    Five highly conserved polar residues connected by a number of structural water molecules together with two rotamer micro-switches, TrpVI:13 and TyrVII:20, constitute an extended hydrogen bond network between the intracellular segments of TM-I, -II, -VI, and -VII of 7TM receptors. Molecular dynamics...... simulations showed that, although the fewer water molecules in rhodopsin were relatively movable, the hydrogen bond network of the beta2-adrenergic receptor was fully loaded with water molecules that were surprisingly immobilized between the two rotamer switches, both apparently being in their closed...... conformation. Manipulations of the rotamer state of TyrVII:20 and TrpVI:13 demonstrated that these residues served as gates for the water molecules at the intracellular and extracellular ends of the hydrogen bond network, respectively. TrpVI:13 at the bottom of the main ligand-binding pocket was shown...

  9. Formulating the spring discharge-function for the recession period ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science; Volume 122; Issue 5. Formulating the spring discharge-function for the recession period by analyzing its recession curve: A case study of the Ranichauri spring (India) ... Keywords. Spring hydrograph; exponential fitting; gravity spring; recession period; recession curve.

  10. Hydrochemical Characteristics of Springs in Oke–Igbo, Ondo State ...

    African Journals Online (AJOL)

    Michael Horsfall

    ABSTRACT: This study was carried out to determine the hydrochemical characteristics of six springs in Oke-. Igbo community, Ondo state, .... organisms. Spring water pH was generally low ranging from slightly acid in Majeroku, Omi Iya. Isobo and Ogiran springs to acidic in Omi Iye, Ojege. Amuye and Egbatedo springs.

  11. EFEKTIFITAS PENGGUNAAN MEDIA FILM UNTUK MENINGKATKAN EMPATI SISWA KELAS VII SMP

    Directory of Open Access Journals (Sweden)

    Alan Auliyah

    2016-03-01

    Full Text Available Abstract: This study aims to determine the effectiveness of the use of film to improving emphaty sevents grade students junior high school. The study design used a quasi-experimental design using the design of one group pretest-posttest design. Subjects in this study were six students who have the lowest levels of emphaty in the classroom. The research instrument used is the scale of emphaty and guidance experiment. The hypothesis testing is using the Wilcoxon test. Wilcoxon test results showed that the difference value (z is-2.201 with a significance value of 0.028. Significance value less than 0.05, which means that Ho is rejected, so it can be concluded that the use of film is effective to improving emphaty among sevents grade student of junior high school.   Abstrak: Penelitian ini bertujuan untuk mengetahui keefektifan penggunaan media film untuk meningkatkan empati siswa kelas VII SMP. Desain penelitian menggunakan desain eksperimen semu dengan menggunakan rancangan one group pretest-posttest design. Subjek dalam penelitian ini adalah enam siswa yang mempunyai tingkat empati terendah dalam satu kelas. Instrumen penelitian yang digunakan adalah skala empati dan pedoman eksperimen.Uji hipotesis dalam penelitian ini menggunakan uji Wilcoxon. Hasil uji Wilcoxon menunjukkan bahwa nilai beda (z adalah -2,201 dengan nilai signifikansi 0,028. Nilai signifikansi lebih kecil dari 0,05 yang artinya Ho ditolak, sehingga dapat disimpulkan bahwa penggunaan media film efektif untuk meningkatkan empati siswa kelas VII SMP.

  12. ANALISIS KESALAHAN SISWA SMP KELAS VII DALAM MENYELESAIKAN SOAL CERITA PEMECAHAN MASALAH BERDASARKAN PROSEDUR NEWMAN

    Directory of Open Access Journals (Sweden)

    Tuti Haryati

    2016-04-01

    Full Text Available Artikel ini didasarkan pada penelitian kualitatif. Tujuan penelitian ini adalah mendeskripsikan (1 tipe kesalahan siswa berdasarkan prosedur Newman yang dilakukan siswa kelas VII SMP Negeri 2 Wonosobo dalam menyelesaikan soal cerita pemecahan masalah; (2 penyebab kesalahan siswa tersebut; dan (3 solusi untuk meminimalkan kesalahan tersebut. Pengumpulan data dilakukan menggunakan metode tes dan wawancara. Subjek penelitian diambil 6 orang dari 32 siswa kelas VII E, masing-masing terdiri dari 2 siswa dari kelompok atas, sedang, bawah. Uji keabsahan data, dilakukan dengan triangulasi teknik. Hasil penelitian menunjukkan bahwa (1 semakin tinggi kategori pada prosedur Newman maka semakin banyak kesalahan yang dilakukan oleh siswa, subjek pada kelompok atas mengalami kesalahan pada tahap transfomasi, keterampilan proses, dan penulisan, subjek pada kelompok sedang mengalami kesalahan pada tahap trasformasi dan penulisan, serta subjek pada kelompok bawah mengalami kesalahan pada tahap memahami dan transformasi; (2 penyebabnya yaitu siswa tidak utuh dalam mengidentifikasi informasi yang diketahui dan yang ditanyakan, tidak tepat memanipulasi aljabar dari soal, kesalahan dalam melakukan operasi aljabar, tidak membuat kesimpulan, serta siswa tersebut tidak sengaja melakukan kesalahan namun siswa tersebut dapat memperbaiki kesalahannya; dan (3 solusi untuk meminimalkan kesalahan tersebut yaitu siswa perlu lebih banyak dilatih untuk menyelesaikan soal-soal tidak rutin sehingga siswa akan terampil dalam menyelesaikannya

  13. A novel subgroup 16SrVII-D phytoplasma identified in association with Erigeron witches' broom.

    Science.gov (United States)

    Flôres, Daniela; Amaral Mello, Ana Paula de Oliveira; Pereira, Thays Benites Camargo; Rezende, Jorge Alberto Marques; Bedendo, Ivan Paulo

    2015-08-01

    Erigeron sp. plants showing symptoms of witches' broom and stunting were found near orchards of passion fruit in São Paulo state, Brazil. These symptoms were indicative of infection by phytoplasmas. Thus, the aim of this study was to detect and identify possible phytoplasmas associated with diseased plants. Total DNA was extracted from symptomatic and asymptomatic plants and used in nested PCR conducted with the primer pairs P1/Tint and R16F2n/16R2. Amplification of genomic fragments of 1.2 kb from the 16S rRNA gene confirmed the presence of phytoplasma in all symptomatic samples. The sequence identity scores between the 16S rRNA gene of the phytoplasma strain identified in the current study and those of previously reported 'Candidatus Phytoplasma fraxini'-related strains ranged from 98% to 99% indicating the phytoplasma to be a strain affiliated with 'Candidatus Phytoplasma fraxini'. The results from a phylogenetic analysis and virtual RFLP analysis of the 16S rRNA gene sequence with 17 restriction enzymes revealed that the phytoplasma strain belongs to the ash yellows phytoplasma group (16SrVII); the similarity coefficient of RFLP patterns further suggested that the phytoplasma represents a novel subgroup, designated 16SrVII-D. The representative of this new subgroup was named EboWB phytoplasma (Erigeron bonariensis Witches' Broom).

  14. Craniofacial abnormalities in animal models of mucopolysaccharidoses I, VI, and VII.

    Science.gov (United States)

    Sheridan, O; Wortman, J; Harvey, C; Hayden, J; Haskins, M

    1994-01-01

    The genetic mucopolysaccharidoses (MPS) are a family of lysosomal storage diseases resulting from the partial catabolism of several glycosaminoglycans (GAGs). Depending on the particular enzyme deficient in activity, the MPS syndromes are defined into groups MPS I through VII, with several subgroups for a total of 10 disorders. In humans, clinical features include dysostosis multiplex, hepatosplenomegaly, hypertelorism, macroglossia, hypoplastic and irregularly shaped teeth, hyperplastic lips and gingiva, facial dysmorphia, corneal clouding, and mental retardation. MPS I (alpha-L-iduronidase deficiency) and VI (arylsulfatase B deficiency) have been described in cats, MPS VII (beta-glucuronidase deficiency) in dogs. Biochemically, these syndromes appear the same as their human counterparts and have similar clinical characteristics. All are inherited as autosomal recessive traits. The purpose of this study was to analyze the craniofacial aspects of these diseases in the animal models and compare these data with descriptions of the human syndromes. A total of 28 live animals were examined. Thirty-one skulls prepared from postmortem specimens were measured directly and radiographed. Controls were closely related family members of the same sex and similar age without the disease, clinically or biochemically. The data indicated that, as in the human syndromes, each is distinct, and the skull bones most severely affected are those of endochondral origin.

  15. Nitric Oxide Sensing in Plants Is Mediated by Proteolytic Control of Group VII ERF Transcription Factors

    Science.gov (United States)

    Gibbs, Daniel J.; Md Isa, Nurulhikma; Movahedi, Mahsa; Lozano-Juste, Jorge; Mendiondo, Guillermina M.; Berckhan, Sophie; Marín-de la Rosa, Nora; Vicente Conde, Jorge; Sousa Correia, Cristina; Pearce, Simon P.; Bassel, George W.; Hamali, Bulut; Talloji, Prabhavathi; Tomé, Daniel F.A.; Coego, Alberto; Beynon, Jim; Alabadí, David; Bachmair, Andreas; León, José; Gray, Julie E.; Theodoulou, Frederica L.; Holdsworth, Michael J.

    2014-01-01

    Summary Nitric oxide (NO) is an important signaling compound in prokaryotes and eukaryotes. In plants, NO regulates critical developmental transitions and stress responses. Here, we identify a mechanism for NO sensing that coordinates responses throughout development based on targeted degradation of plant-specific transcriptional regulators, the group VII ethylene response factors (ERFs). We show that the N-end rule pathway of targeted proteolysis targets these proteins for destruction in the presence of NO, and we establish them as critical regulators of diverse NO-regulated processes, including seed germination, stomatal closure, and hypocotyl elongation. Furthermore, we define the molecular mechanism for NO control of germination and crosstalk with abscisic acid (ABA) signaling through ERF-regulated expression of ABSCISIC ACID INSENSITIVE5 (ABI5). Our work demonstrates how NO sensing is integrated across multiple physiological processes by direct modulation of transcription factor stability and identifies group VII ERFs as central hubs for the perception of gaseous signals in plants. PMID:24462115

  16. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects.

    Science.gov (United States)

    Hsia, Chien-Hsun; Shen, Ming-Ching; Lin, Jen-Shiou; Wen, Yao-Ke; Hwang, Kai-Lin; Cham, Thau-Ming; Yang, Nae-Cherng

    2009-03-01

    Nattokinase, a serine proteinase from Bacillus subtilis, is considered to be one of the most active functional ingredients found in natto. In this study, we hypothesized that nattokinase could reduce certain factors of blood clotting and lipids that are associated with an increase risk for cardiovascular disease (CVD). Thus, an open-label, self-controlled clinical trial was conducted on subjects of the following groups: healthy volunteers (Healthy Group), patients with cardiovascular risk factors (Cardiovascular Group), and patients undergoing dialysis (Dialysis Group). All subjects ingested 2 capsules of nattokinase (2000 fibrinolysis units per capsule) daily orally for 2 months. The laboratory measurements were performed on the screening visit and, subsequently, regularly after the initiation of the study. The intent-to-treat analysis was performed on all 45 enrolled subjects. By use of mixed model analysis, a significant time effect, but not group effect, was observed in the change from baseline of fibrinogen (P = .003), factor VII (P nattokinase. No significant changes of uric acid or notable adverse events were observed in any of the subjects. In summary, this study showed that oral administration of nattokinase could be considered as a CVD nutraceutical by decreasing plasma levels of fibrinogen, factor VII, and factor VIII.

  17. DESAIN PEMBELAJARAN PELUANG DENGAN PENDEKATAN PMRI MENGGUNAKAN KUPON UNDIAN UNTUK SISWA KELAS VII

    Directory of Open Access Journals (Sweden)

    Welly Yanti

    2016-01-01

    Full Text Available This research aims to determine the role of lottery coupons can help students find the concept of probability for class VII. Design Research had chose as a kind of research to achieve the goal. In this reseacrh, a series of learning activities designed and developed based on the hypothesis of the learning process of students. Learning approach used,that is, PMRI approach by involving 32 students of class VII MTs Campang Tiga. This research result Learning trajectory (LT, which contains a series of learning processes in the two activities, that is, understand the concept of sample space, sample point and the event occurrence. Results of the experiments show that with the approach of learning PMRI can define the concept of sample space and sample points and probabilities of an event by taking the lottery tickets. With the line of learning from taking lottery tickets, determine the sample space and sample point and determine the probability of occurrence can improve comprehension, reasoning students on the matters of probability.

  18. Successful Hemostasis with Recombinant Activated Factor VII in a Patient with Massive Hepatic Subcapsular Hematoma

    Directory of Open Access Journals (Sweden)

    Ju-Hee Lee

    2009-02-01

    Full Text Available Recombinant activated coagulation factor VII (rFVIIa is known to be effective in the management of acquired deficiencies of factor VII and platelet function defects. But recently, rFVIIa has been successfully used to treat ongoing bleeding in disseminated intravascular coagulopathy (DIC condition. The patient reported here was suspected to be suffering from toxic hepatitis on admission. After percutaneous liver biopsy, bleeding occurred and did not stop even after right hepatic artery embolization. The patient developed a severe hemorrhage that resulted in hypovolemic shock, hemoperitoneum, and a massive subcapsular hematoma. The patient then developed DIC due to massive transfusion, as well as acute liver necrosis. The patient was given 400 μg/kg of rFVIIa. Recombinant factor VIIa was administered in an attempt to control the bleeding. This stabilized the hemoglobin levels of the patient. The patient gradually recovered in 4 months. In conclusion, this case suggests that rFVIIa can be successfully used for the hemostasis of uncontrolled bleeding in DIC.

  19. Spring Bird Migration Phenology in Eilat, Israel

    Directory of Open Access Journals (Sweden)

    Reuven Yosef

    2009-12-01

    Full Text Available Analysis of the mean date of first captures and median arrival dates of spring migration for 34 species of birds at Eilat, Israel, revealed that the earlier a species migrates through Eilat, the greater is the inter-annual variation in the total time of its passage. Birds arrive during spring migration in Eilat in four structured and independent waves. The annual fluctuation in the initial arrival dates (initial capture dates and median dates (median date of all captures, not including recaptures, did not depend on the length of the migratory route. This implies that migrants crossing the Sahara desert depart from their winter quarters on different Julian days in different years. We suggest that negative correlations between the median date of the spring migration of early and late migrants depends upon the easterly (Hamsin wind period. Moreover, we believe that the phenology of all birds during spring migration in Eilat is possibly also determined by external factors such as weather conditions on the African continent or global climatic processes in the Northern hemisphere. Orphean Warblers (Sylvia hortensis show a strong positive correlation (rs=-0.502 of initial capture date with calendar years, whereas other species such as Barred Warbler (S. nisoria; rs = -0.391 and Spotted Flycatcher (Muscicapa striata; rs = -0.398 display an insignificant trend. The Dead Sea Sparrow (Passer moabiticus and Red-Backed Shrike (Lanius collurio are positively correlated regarding initial arrival date and medians of spring migration.

  20. Characterization of the hydrogeology of the sacred Gihon Spring, Jerusalem: a deteriorating urban karst spring

    Science.gov (United States)

    Amiel, Ronit Benami; Grodek, Tamir; Frumkin, Amos

    2010-09-01

    The Gihon Spring, Jerusalem, is important for the major monotheistic religions. Its hydrogeology and hydrochemistry is studied here in order to understand urbanization effects on karst groundwater resources, and promote better water management. High-resolution monitoring of the spring discharge, temperature and electrical conductivity, was performed, together with chemical and bacterial analysis. All these demonstrate a rapid response of the spring to rainfall events and human impact. A complex karst system is inferred, including conduit flow, fissure flow and diffuse flow. Electrical conductivity, Na+ and K+ values (2.0 mS/cm, 130 and 50 mg/l respectively) are very high compared to other nearby springs located at the town margins (0.6 mS/cm, 15 and <1 mg/l respectively), indicating considerable urban pollution in the Gihon area. The previously cited pulsating nature of the spring was not detected during the present high-resolution monitoring. This phenomenon may have ceased due to additional water sources from urban leakage and irrigation feeding the spring. The urbanization of the recharge catchment thus affects the spring water dramatically, both chemically and hydrologically. Appropriate measures should therefore be undertaken to protect the Gihon Spring and other karst aquifers threatened by rapid urbanization.

  1. Determinación del estado de salud bucal en pacientes discapacitados del Área VII en Cienfuegos

    OpenAIRE

    Ana Belkys Hernández Millán; Irma Aracelia Sueiro Sánchez; Caridad Delfina Manresa Peñalver; Zenia Lissette Hernández Millán; Dania Lissette Hurtado Sánchez; Teresita de Jesús Barrio Pedraza

    2014-01-01

    Fundamento: la discapacidad constituye una preocupación social, sin embargo, se cuenta con pocos estudios sobre el estado de salud bucal de los pacientes discapacitados. Objetivo: determinar el estado de salud bucal en pacientes discapacitados del Área VII de la provincia Cienfuegos. Métodos: se realizó un estudio descriptivo, de serie de casos, del Área VII del municipio de Cienfuegos, en el periodo de enero-diciembre de 2013. Se estudiaron 192 discapacitados que acudieron a consulta estomat...

  2. 77 FR 29633 - Alta Wind VII, LLC, Alta Wind IX, LLC, Alta Wind X, LLC, Alta Wind XI, LLC, Alta Wind XII, LLC...

    Science.gov (United States)

    2012-05-18

    ... Wind VII, LLC, Alta Wind IX, LLC, Alta Wind X, LLC, Alta Wind XI, LLC, Alta Wind XII, LLC, Alta Wind XIII, LLC, Alta Wind XIV, LLC, Alta Wind XV, LLC, Alta Windpower Development, LLC, TGP Development... 385.207, Alta Wind VII, LLC, Alta Wind IX, LLC, Alta Wind X, LLC, Alta Wind XI, LLC, Alta Wind XII...

  3. Low sensitivity of type VII collagen enzyme-linked immunosorbent assay in epidermolysis bullosa acquisita : serration pattern analysis on skin biopsy is required for diagnosis

    NARCIS (Netherlands)

    Terra, J. B.; Jonkman, M. F.; Diercks, G. F. H.; Pas, H. H.

    BackgroundThe type VII collagen (coll VII) enzyme-linked immunosorbent assay (ELISA) has been reported to have high sensitivity (>93%) and specificity (>96%) for diagnosing epidermolysis bullosa acquisita (EBA) in patients who are seropositive on indirect immunofluorescence on salt-split skin (SSS).

  4. Springing response due to bidirectional wave excitation

    DEFF Research Database (Denmark)

    Vidic-Perunovic, Jelena

    2005-01-01

    Springing is a two-node high frequency resonant vibration of the hull induced by unsteady wave pressure field on the hull. The excitation force may be rather complex - any wave activity (or their combination) in the Ocean matching the two-node natural hull vibration frequency. With some ship...... designs the hull natural frequency may get low enough that the corresponding level of excitation energy becomes large. Springing vibration negatively influences the fatigue life of the ship but, paradoxically, it still doesn't get much attention of the technical society. Usually, non-linear hydroelastic...... theories deal with the unidirectional wave excitation. This is quite standard. The problem is how to include more than one directional wave systems described by a wave spectrum with arbitrary heading. The main objective of the present work has been to account for the additional second-order springing...

  5. Nonlinear Squeeze Film Dampers without Centralized Springs

    Directory of Open Access Journals (Sweden)

    Zhu Changsheng

    2000-01-01

    Full Text Available In this paper, the bifurcation behavior of a flexible rotor supported on nonlinear squeeze film dampers without centralized springs is analyzed numerically by means of rotor trajectories, Poincar maps, bifurcation diagrams and power spectra, based on the short bearing and cavitated film assumptions. It is shown that there also exist two different operations (i.e., socalled bistable operations in some speed regions in the rotor system supported on the nonlinear squeeze film dampers without centralized springs. In the bistable operation speed regions, the rotor system exhibits synchronous, sub-synchronous, sub-super-synchronous and almost-periodic as well as nonperiodic motions. The periodic bifurcation behaviors of the rotor system supported on nonlinear squeeze film dampers without centralized springs are very complex and require further investigations.

  6. FATIGUE PROPERTIES OF SPRING REINFORCES POLYMER GEARS

    Directory of Open Access Journals (Sweden)

    Hilal CAN

    2005-03-01

    Full Text Available Failure of gears, occur surface pressure stress and fracture at base of teeth. For steel gears, it is known that process of carburizing increases fatigue strength. Internal stress on the surface increases of fracture fatigue strength. In this study fatigue properties of polypropylene gear reinforced with 1.2 mm wire diameter metallic springs was investigated. Extension springs were used as reinforcement element and placed into the mould and stretched before injection of polypropylene material into the mould. After injection of polypropylene, stretched springs were loosened in order to obtain pre-stressing. Fatigue tests were performed on the produced gear. Reinforcement increased the strength of gears. At result of experiments, pre-stressing increase in service life 12 times more than that of specimens without reinforcement.

  7. Spring Deposits and Mud Volcanoes on Mars

    Science.gov (United States)

    Allen, C. C.; Oehler, D. Z.; Baker, D. M.

    2008-12-01

    We report evidence for spring deposits in Vernal Crater, Arabia Terra. The Vernal structures are low mounds, each approximately 250 m by 500 m in extent, with terraced flanks, apical depressions, river-like channels, concentric fractures, and elliptical tonal anomalies. All of these features are common in terrestrial springs such as the Dalhousie complex in Australia. The structures occur in an apparent unit of interdune, water-laid sediment and are associated with evidence of subsurface fluid flow in sets of aligned outcrops. The Vernal springs may be part of a larger complex of spring deposits and lineations, suggesting that fluid flow in this region was relatively extensive. The structures in Vernal Crater are coated with a thin layer of dust, which prevents mineral identification from orbit. In an attempt to find evidence for additional spring mounds, we conducted a survey of nearly 2,000 locations for which CRISM spectral images are available. We used CRISM data to identify dust-free, hydrated areas and HiRISE, CTX, and MOC images to evaluate morphology. This study covered all longitudes and latitudes from 50N to 70S, except near Tharsis where data were analyzed south of 15S. No location exhibited morphological features that closely resembled those in Vernal Crater, suggesting that these putative spring mounds are not common in the highlands of Mars. Our search led us to concentrate on a dust-free area, centered at 41.8N, 332.5E in Acidalia Planitia where Farrand et al. (2005) identified features resembling spring mounds or mud volcanoes. Tanaka et al. (2005) mapped this region as part of the Early Amazonian Vastitas Borealis Unit, interpreted as reworked sediments from outflow channels and highland sources. We mapped over 20 high-albedo pitted domes in the area covered by one HiRISE frame, with dome diameters ranging from 350 m to 1 km. Nearby, similar domes have measured heights ranging from 36 to 65 m. The dome material is darker in THEMIS nighttime IR than

  8. Nonlinear Study of Industrial Arc Spring Dampers

    DEFF Research Database (Denmark)

    Lahriri, Said; Santos, Ilmar; Hartmann, Henning

    2011-01-01

    The objective of this paper is to present a numerical approach for analyzing parameter excited vibrations on a gas compressor, induced by the nonlinear characteristic of the arc spring feature of certain designs of squeeze film dampers, SFDs. The behavior of the journal is studied in preparation...... acting on the SFD are presented. It is worth mentioning, that the maps and diagrams can be used as design guidance. Finally, a comparison between the numerical results and experimental result is facilitated in form of waterfall diagrams. For this, a full scale model of the arc-spring damper was designed...

  9. Evaluación de Spring MVC

    OpenAIRE

    Mayor Martín, David

    2014-01-01

    Spring Framework cuenta con su propio framework de aplicaciones web basado en el Modelo Vista Controlador (MVC). Los desarrolladores de Spring decidieron escribir su propio framework web como una reacción a lo que percibían como el mal diseño de Jakarta Struts framework web, así como por las deficiencias en otros frameworks disponibles. En particular, sentían que no había la separación suficiente entre las capas de presentación y tratamiento de la petición, y entre las capas de...

  10. Characterisation of genotype VII Newcastle disease virus (NDV) isolated from NDV vaccinated chickens, and the efficacy of LaSota and recombinant genotype VII vaccines against challenge with velogenic NDV.

    Science.gov (United States)

    Roohani, Kiarash; Tan, Sheau Wei; Yeap, Swee Keong; Ideris, Aini; Bejo, Mohd Hair; Omar, Abdul Rahman

    2015-01-01

    A Newcastle disease virus (NDV) isolate designated IBS002 was isolated from a commercial broiler farm in Malaysia. The virus was characterised as a virulent strain based on the multiple basic amino acid motif of the fusion (F) cleavage site (112)RRRKGF(117) and length of the C-terminus extension of the hemagglutinin-neuraminidase (HN) gene. Furthermore, IBS002 was classified as a velogenic NDV with mean death time (MDT) of 51.2 h and intracerebral pathogenicity index (ICPI) of 1.76. A genetic distance analysis based on the full-length F and HN genes showed that both velogenic viruses used in this study, genotype VII NDV isolate IBS002 and genotype VIII NDV isolate AF2240-I, had high genetic variations with genotype II LaSota vaccine. In this study, the protection efficacy of the recombinant genotype VII NDV inactivated vaccine was also evaluated when added to an existing commercial vaccination program against challenge with velogenic NDV IBS002 and NDV AF2240-I in commercial broilers. The results indicated that both LaSota and recombinant genotype VII vaccines offered full protection against challenge with AF2240-I. However, the LaSota vaccine only conferred partial protection against IBS002. In addition, significantly reduced viral shedding was observed in the recombinant genotype VII-vaccinated chickens compared to LaSota-vaccinated chickens.

  11. A new automated method for continuous registration of factor VII activation in vitro. Activation is accelerated by the concentration of factor VII and the activity state of the protein

    DEFF Research Database (Denmark)

    Bladbjerg, Else-Marie; Jespersen, J; Gram, J

    1994-01-01

    . In this system, FVII activation follows parabolic kinetic after an initial lag-phase. The slope of the linear phase is a measure of the protein concentration of factor VII (FVIItotal), while the length of the non-linear phase represents the velocity of FVII activation. The time required for complete activation...

  12. Atomic Structures of Minor Proteins VI and VII in the Human Adenovirus.

    Science.gov (United States)

    Dai, Xinghong; Wu, Lily; Sun, Ren; Zhou, Z Hong

    2017-10-04

    Human adenoviruses (Ad) are dsDNA viruses associated with infectious diseases, yet better known as tools for gene delivery and oncolytic anti-cancer therapy. Atomic structures of Ad provide the basis for the development of antivirals and for engineering efforts towards more effective applications. Since 2010, atomic models of human Ad5 have been independently derived from photographic film cryoEM and X-ray crystallography, but discrepancies exist concerning the assignment of cement proteins IIIa, VIII and IX. To clarify these discrepancies, here we have employed the technology of direct electron-counting to obtain a cryoEM structure of human Ad5 at 3.2 Å resolution. Our improved structure unambiguously confirmed our previous cryoEM models of proteins IIIa, VIII and IX and explained the likely cause of conflict in the crystallography models. The improved structure also allows the identification of three new components in the cavities of hexons - the cleaved N-terminus of precursor protein VI (pVIn), the cleaved N-terminus of precursor protein VII (pVIIn2), and mature protein VI. The binding of pVIIn2--by extension that of genome-condensing pVII--to hexons is consistent with the previously proposed dsDNA genome-capsid co-assembly for adenoviruses, which resembles that of ssRNA viruses but differs from the well-established mechanism of pumping dsDNA into a preformed protein capsid, as exemplified by tailed bacteriophages and herpesviruses. IMPORTANCE Adenovirus is a double-edged sword to humans - as a widespread pathogen and a bioengineering tool for anti-cancer and gene therapy. Atomic structure of the virus provides the basis for antiviral and application developments, but conflicting atomic models from conventional/film cryoEM and X-ray crystallography for important cement proteins IIIa, VIII, and IX have caused confusion. Using the cutting-edge cryoEM technology with electron counting, we improved the structure of human adenovirus type 5 and confirmed our

  13. Does artificial UV use prior to spring break protect students from sunburns during spring break?

    Science.gov (United States)

    Dennis, Leslie K; Lowe, John B

    2013-06-01

    Dark-skinned individuals are less likely than light-skinned individuals to become sunburned or develop skin cancer. Some have extrapolated this relationship and surmised that developing and maintaining a tan will reduce the risk of sunburns and melanoma. In order to examine whether this strategy indeed protects against sunburns, we surveyed college students about both their tanning habits prior to spring break and their spring break activities. Sorority and fraternity students were recruited after spring break. Analyses examined associations between potential risk factors and the development of one or more sunburns during spring break. As expected, the risk of obtaining a sunburn increased with: time spent in the sun during spring break; light complexion, as assessed by various sun-sensitivity factors; and lack of sunscreen use. We also found that tanning using an artificial UV source during the 10 weeks prior to spring break was not associated with reduced risk of sunburns during spring-break, but rather with a marginal increase in this risk. These data provide evidence that maintaining a tan may not provide protection from sunburns. Public health messages need to address this misconception, stating clearly that a tan does not protect against or reduce the chances of developing a sunburn. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  14. Title VII Enhancement Project for Compartiendo Culturas/Sharing Cultures 1995-96. Research Report on Educational Programs.

    Science.gov (United States)

    Houston Independent School District, TX. Dept. of Research and Evaluation.

    Compartiendo Culturas/Sharing Cultures, a Title VII Two-Way Developmental Bilingual Education Program at the Gary L. Herod Elementary School in the Houston Independent School District (Texas) was designed to end the isolation typically experienced by language minority students in traditional bilingual education and to provide language majority…

  15. 75 FR 51429 - Definitions Contained in Title VII of Dodd-Frank Wall Street Reform and Consumer Protection Act

    Science.gov (United States)

    2010-08-20

    ... floor; (III) A rate cap; (IV) A rate collar; (V) A cross-currency rate swap; (VI) A basis swap; (VII) A currency swap; (VIII) A foreign exchange swap; (IX) A total return swap; (X) An equity index swap; (XI) An... agreements, contracts, or transactions in foreign currency pursuant to section 2(c)(2).'' Security-Based Swap...

  16. Marine Mammals, Coastal and River Issues. Alaska Sea Week Curriculum Series VII. Alaska Sea Grant Report 84-8.

    Science.gov (United States)

    Mickelson, Belle

    This curriculum guide is the last (Series VII) in a six-volume set that comprises the Sea Week Curriculum Series developed in Alaska. The guide lends itself to the sixth-grade curriculum but can be adapted to preschool, secondary, and adult education. Eight units contain 43 activities with worksheets that cover the following topics: (1) the values…

  17. Steekproef voor de bodemeigenschappen en grondwatertrappen van de Bodemkaart van Nederland schaal 1 : 50 000; kaarteenheden met Gt VII

    NARCIS (Netherlands)

    Visschers, R.

    1999-01-01

    Door een gestratficeerde aselecte steekproef in kaarteenheden met grondwatertrap VII van de Bodemkaart van Nederland schaal 1 : 50 000 is statistisch betrouwbare informatie verkregen over de gemiddeld hoogste en laagste grondwaterstand (GHG en GLG), bodemparameters (CEC, pH, humusgehalte, lutum,

  18. The Effect of Recombinant Activated Factor VII on Mortality in Combat-Related Casualties With Severe Trauma and Massive Transfusion

    Science.gov (United States)

    2008-02-01

    control of bleeding in patients with hemophilia with inhibitors to factor VIII concentrate. Addi- tionally, it is licensed in Europe for patients with...Holcomb JB. Use of recombinant activated factor VII to treat the acquired coagulopathy of trauma. J Trauma. 2005;58:1298–1303. 22. AAAM (2005

  19. Development of an ELISA for Rapid Detection of Anti-Type VII Collagen Autoantibodies in Epidermolysis Bullosa Acquisita

    National Research Council Canada - National Science Library

    Chen, M; Chan, L S; Cai, X; O'Toole, E A; Sample, J C; Woodley, D T

    1997-01-01

    .... In this study, we developed a rapid, quantitative enzyme-linked immunosorbent assay (ELISA) to detect autoantibody activity against the complete NC1 domain of type VII collagen with the use of an eukaryotic-expressed, recombinant human NC1 antigen...

  20. GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors

    DEFF Research Database (Denmark)

    Rosenkilde, Mette M; Schwartz, Thue W

    2006-01-01

    to be crucially important for the binding and action of a number of non-peptide ligands in for example the CCR1, CCR2 and CCR5 receptors. It is proposed that in chemokine receptors in general GluVII:06 serves as a selective anchor point for the centrally located, positively charged nitrogen of the small molecule...

  1. The protein concentration of blood coagulation factor VII can be measured equally well in plasma and serum

    DEFF Research Database (Denmark)

    Bladbjerg, E-M; Overgaard, K; Gram, J

    1995-01-01

    In the Northwick Park Heart Study, the coagulant activity of factor VII (FVII:C) has been identified as a risk marker of ischaemic heart disease. In the fasting state, the protein concentration of FVII (FVII:Ag) might be an even better risk marker, because of the low coefficient of variation...

  2. John Jay High School Project "Rescate." E.S.E.A. Title VII. Final Evaluation Report, 1980-1981.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Office of Educational Evaluation.

    This report describes and presents 1980-81 evaluation results for Project Rescate at John Jay High School in New York City. The project, which was funded under Title VII of the Elementary Secondary Education Act, provided instruction in English as a Second Language and in native language skills for limited proficient students. Bilingual…

  3. Inflammatory variant of epidermolysis bullosa acquisita with IgG autoantibodies against type VII collagen and laminin alpha 3

    NARCIS (Netherlands)

    Jonkman, MF; Schuur, J; Dijk, F; Heeres, K; de Jong, MCJM; van der Meer, JB; Yancey, KB; Pas, HH

    Background: The inflammatory variant of epidermolysis bullosa acquisita (EBA) may clinically closely resemble bullous or cicatricial pemphigoid. Patients with inflammatory EBA have IgG autoantibodies against type VII collagen. Patients with anti-epiligrin cicatricial pemphigoid have IgG

  4. Hydrogeochemistry of Damt thermal springs, Yemen Republic

    Energy Technology Data Exchange (ETDEWEB)

    Fara, M. [Sana' a University, Yemen Republic (Yemen). Dept. of Geology; Chandrasekharam, D. [Indian Institute of Technology, Bombay (India). Dept. of Earth Sciences; C.N.R. Center for Minerogenesis and Applied Geochemistry, Florence (Italy); Minissale, A. [C.N.R. Center for Minerogenesis and Applied Geochemistry, Florence (Italy)

    1999-04-01

    The Damt thermal springs (40-45{sup o}C), flowing through travertine deposits, belong to the Na-HCO{sub 3} type of water, and have higher pCO{sub 2} (from -1.18 to -0.58 = PCO{sub 2} from 0.07 to 0.26 atm) relative to cold Ca-SO{sub 4}-(Cl) groundwaters. The cold waters have pCO{sub 2} ranging from -1.86 to -2.50 (= PCO{sub 2} from 0.014 to 0.0035 atm). The chemical composition of the cold springs is controlled by evaporate deposits present in the Tawilah sandstone and Amran limestone formations, while simple crustal dissolution, coupled with CO{sub 2}-rich fluid-rock interaction control the chemical signature of the hot spring waters. The temperature of the feeding system, based on the K{sup 2}/Mg geothermometer, varies between 80 and 120{sup o}C. Damt thermal springs appear to be related to a 10,000 year-old volcanic activity that led to the appearance of several craters in the area. (author)

  5. AAAI 1991 Spring Symposium Series Reports

    OpenAIRE

    AAAI,

    1991-01-01

    The Association for the Advancement of Artificial Intelligence held its 1991 Spring Symposium Series on March 26-28 at Stanford University, Stanford, California. This article contains short summaries of the eight symposia that were conducted: Argumentation and Belief, Composite System Design, Connectionist Natural Language Processing, Constraint-Based Reasoning, Implemented Knowledge Representation and Reasoning Systems, Integrated Intelligent Architectures, Logical Formalizations of Commonse...

  6. The Silent Spring of Rachel Carson.

    Science.gov (United States)

    Kerstetter, Ned

    1996-01-01

    Presents a lesson plan examining Rachel Carson's call to arms concerning the harmful consequences of pesticides. Students view a video documentary on Carson's work and read a synopsis of her book, "Silent Spring." Assessment is provided by various activities including writing assignments, creating posters, and editorial cartoons. (MJP)

  7. Ultrabasic Spring Geomicrobiology of the Cedars Peridotite

    Science.gov (United States)

    Johnson, O. J.; Morrill, P.; Muyzer, G.; Kuenen, J. G.; Nealson, K. H.

    2006-12-01

    Peridotite hosted aquifers are becoming well-known as a modern analog for both extraterrestrial and early- Earth habitats despite relatively few studies on microbes in ultramafic systems. To investigate the microbiology associated with aquifers of the actively serpentinizing Cedars Peridotite in coastal Northern California an interdisciplinary approach involving molecular phylogenetics, organic and inorganic geochemistry, as well as culture-based ecophysiological methods are being utilized. Based on our findings, Cedars spring microorganisms endure one of the harshest low-temperature aqueous environments on Earth with pH greater than 11.8, Eh less than -600 mV, undetectable dissolved CO2 and O2 and a lack of other obvious e- acceptors. Despite these conditions, life inhabits solid substrate surfaces within the springs to a concentration of 10E6-10E7 cells/sq. cm, but planktonic cell densities are extremely low (much less than 10E3/ml). Preliminary 16S data of 3 ultrabasic fluids reveals a community comprised primarily of bacteria that appears to be of low-diversity. Methanogens are strongly suggested to be present based on the isotopic composition of methane bubbling from the springs, but have not yet been identified via molecular techniques. Community level metagenomic sequencing of the ultrabasic spring microorganisms sampled from peridotite-associated mineral surfaces and glass slides incubated in specially designed flow- through chambers are currently in-progress and are likely to reveal several novel metabolic pathways.

  8. Climate change and spring-fruiting fungi.

    Science.gov (United States)

    Kauserud, Håvard; Heegaard, Einar; Semenov, Mikhail A; Boddy, Lynne; Halvorsen, Rune; Stige, Leif Chr; Sparks, Tim H; Gange, Alan C; Stenseth, Nils Chr

    2010-04-22

    Most macrofungi produce ephemeral fruit bodies during autumn but some have adapted to spring fruiting. In this study, temporal changes in the time of spring fruiting in Norway and the UK during 1960-2007 have been investigated by statistical analyses of about 6000 herbarium and field records, covering 34 species. Nearly 30 per cent of the temporal variation in fruiting could be ascribed to spatial and species-specific effects. Correcting for these effects, linear trends towards progressively earlier fruiting were detected during the entire period in both Norway and the UK, with a change in average fruiting day of 18 days over the study period. Early fruiting was correlated with high winter temperatures in both countries, indicating that the observed phenological changes are likely due to earlier onset of spring. There were also significant correlations between climatic conditions in one year and timing of fruiting the following year, indicating that below-ground mycelia are influenced by climatic conditions over a longer time period before fruiting. Fruiting dates were, however, not strictly related to changes in vernal accumulated thermal time. Our results indicate that global warming has lead to progressively earlier fruiting of spring fungi in northwest Europe during the last half century.

  9. Registration of 'Prevail' hard red spring wheat

    Science.gov (United States)

    Grower and end-user acceptance of new Hard Red Spring Wheat (HRSW; Triticum aestivum L.) cultivars is largely contingent upon satisfactory agronomic performance, end-use quality potential, and disease resistance levels. Additional characteristics, such as desirable plant height, can also contribute...

  10. Spring reflections on Louisiana sugar cane

    Science.gov (United States)

    The Louisiana sugar industry continues to produce high cane and sugar yields despite a short growing season. Spring fallow land management is essential for the upcoming crop. In the past few years, wide row spacing, billet cane planting, and cover-cropping have received significant attention. The ei...

  11. Experimental demonstration of coupled optical springs

    Science.gov (United States)

    Gordon, N. A.; Barr, B. W.; Bell, A.; Graef, C.; Hild, S.; Huttner, S. H.; Leavey, S. S.; Macarthur, J.; Sorazu, B.; Wright, J.; Strain, K. A.

    2017-02-01

    Optical rigidity will play an important role in improving the sensitivity of future generations of gravitational wave (GW) interferometers, which employ high laser power in order to reach and exceed the standard quantum limit. Several experiments have demonstrated the combined effect of two optical springs on a single system for very low-weight mirror masses or membranes. In this paper we investigate the complex interactions between multiple optical springs and the surrounding apparatus in a system of comparable dynamics to a large-scale GW detector. Using three 100 g mirrors to form a coupled cavity system capable of sustaining two or more optical springs, we demonstrate a number of different regimes of opto-mechanical rigidity and measurement techniques. Our measurements reveal couplings between each optical spring and the control loops that can affect both the achievable increase in sensitivity and the stability of the system. Hence this work establishes a better understanding of the realisation of these techniques and paves the way to their application in future GW observatories, such as upgrades to Advanced LIGO.

  12. Spring Season Habitat Suitability Index raster

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This raster represents a continuous surface of sage-grouse habitat suitability index (HSI, created using ArcGIS 10.2.2) values for Nevada during spring, which is a...

  13. Bacteriological Analysis of Protected Springs in Jimma

    African Journals Online (AJOL)

    were found to percolate adjacent to some springs and appear to be the major sources of contamination in these poorly maintained water supply systems. In smaller towns, absence of diversion ditches, and poor drainage systems around the protection "ox were implicated as contributing factors to water quality deterioration.

  14. Cold Spring Brook Site Investigation Work Plan

    Science.gov (United States)

    1994-11-01

    floodplain is a forested swamp habitat dominated by red maples (Acer rubrum). Various oak species ( Quercus spp.), grey birch (Betula populifolia...Vaccinium corymbosum), and speckled alder (Alnus rugosa ) also occur in the floodplain of Cold Spring Brook. Typical floodplain herbaceous components

  15. Decadal radon cycles in a hot spring.

    Science.gov (United States)

    Yan, Rui; Woith, Heiko; Wang, Rongjiang; Wang, Guangcai

    2017-09-21

    A high-fidelity record covering nearly 40 years of water-dissolved radon from the hot spring site of BangLazhang (BLZ), Southwestern China is presented to study multi-year periodicities of radon. Ancillary observational data, i.e., water temperature, spring discharge rate, barometric pressure, combined with regional rainfall, galactic cosmic rays (GCR flux is modulated by solar wind and thus a proxy for solar activity) and regional seismicity from the same period are considered to identify potentially influencing factors controlling the changes in radon. Variations in radon concentration and ancillary observational data are studied using continuous Wavelet Power Spectrum (WPS), Wavelet Coherence (WTC), and Partial Wavelet Coherence (PWC). The results show that the long-period radon concentration is characterized by a quasi-decadal (8-11 years) cycle, matching well with the concurrent periodicity in water temperature, spring discharge rates and GCR. PWCs of radon, discharge rate and water temperature suggest that water temperature variations explain most of the coherent variability of radon and the discharge rate. We tentatively conclude that radon variations are mainly explained by variations in water temperature and spring discharge, which are modified and modulated by earthquakes and quasi-decadal variations of an unidentified process. The influence of solar activity on the decadal periodicity is discussed.

  16. Pengembangan Perangkat Pembelajaran Strategi IDEAL Problem Solving Berbantuan Puzzquare Materi Luas Daerah Segiempat Kelas VII

    Directory of Open Access Journals (Sweden)

    Eny Susiana

    2011-12-01

    Full Text Available This research is classified as the developmental research. It develops learning materials using IDEAL problem solving strategy supported by Puzzquare for quadrilateral area for grade VII. The goals of this research are the development of learning materials using IDEAL problem solving strategy supported by Puzzquare is valid and learning process using that materials is effective. The development of learning materials on this research used 4-D model (Thiagarajan, Semmel and Semmel: (1 Define, (2 Design, (3 Develop, and (4 Disseminate. The developed learning-materials are (1 syllabus (2 lesson plan, (3 handbook, (4 student activity sheet, and (5 problem solving ability test. Keyword: The Development of Learning Material, IDEAL Problem Solving, Puzzquare

  17. Plasma concentrations of blood coagulation factor VII measured by immunochemical and amidolytic methods

    DEFF Research Database (Denmark)

    Bladbjerg, E-M; Gram, J; Jespersen, J

    2000-01-01

    Ever since the coagulant activity of blood coagulation factor VII (FVII:C) was identified as a risk indicator of cardiac death, a large number of studies have measured FVII protein concentrations in plasma. FVII protein concentrations are either measured immunologically with an ELISA method (FVII......:Ag) or estimated with an amidolytic method (FVII:Am). We have investigated whether FVII:Am is a valuable alternative to FVII:Ag. FVII:Ag and FVII:Am were measured in 147 plasma samples from blood donors, patients on oral anticoagulant therapy, postmenopausal women on hormone replacement therapy, in postprandial...... omitting the data from patients on oral anticoagulant therapy, with mean values of 113 U/ml for FVII:Ag and 110 U/ml for FVII:Am (p slope (beta=1.16) was different from 1.0 (p

  18. Benchmarking Atomic Data for Astrophysics: Be-like Ions between B II and Ne VII

    Science.gov (United States)

    Wang, Kai; Chen, Zhan Bin; Zhang, Chun Yu; Si, Ran; Jönsson, Per; Hartman, Henrik; Gu, Ming Feng; Chen, Chong Yang; Yan, Jun

    2018-02-01

    Large-scale self-consistent multiconfiguration Dirac–Hartree–Fock and relativistic configuration interaction calculations are reported for the n≤slant 6 levels in Be-like ions from B II to Ne VII. Effects from electron correlation are taken into account by means of large expansions in terms of a basis of configuration state functions, and a complete and accurate data set of excitation energies; lifetimes; wavelengths; electric dipole, magnetic dipole, electric quadrupole, and magnetic quadrupole line strengths; transition rates; and oscillator strengths for these levels is provided for each ion. Comparisons are made with available experimental and theoretical results. The uncertainty of excitation energies is assessed to be 0.01% on average, which makes it possible to find and rule out misidentifications and aid new line identifications involving high-lying levels in astrophysical spectra. The complete data set is also useful for modeling and diagnosing astrophysical plasmas.

  19. Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII

    Science.gov (United States)

    Morkūnaitė, Vaida; Baranauskienė, Lina; Zubrienė, Asta; Trapencieris, Pēteris

    2014-01-01

    A series of modified saccharin sulfonamides have been designed as carbonic anhydrase (CA) inhibitors and synthesized. Their binding to CA isoforms I, II, VII, XII, and XIII was measured by the fluorescent thermal shift assay (FTSA) and isothermal titration calorimetry (ITC). Saccharin bound the CAs weakly, exhibiting the affinities of 1–10 mM for four CAs except CA I where binding could not be detected. Several sulfonamide-bearing saccharines exhibited strong affinities of 1–10 nM towards particular CA isoforms. The functional group binding Gibbs free energy additivity maps are presented which may provide insights into the design of compounds with increased affinity towards selected CAs. PMID:25276805

  20. Fuji III vs. Fuji VII glass ionomer sealants--a clinical study.

    Science.gov (United States)

    Kamala, B K; Hegde, Amitha M

    2008-01-01

    Glass ionomer cements possess several properties that support their consideration in a wide variety of clinical applications including Pit and fissure sealants. The aim of this study was to compare and evaluate Fuji III and Fuji VII glass ionomer sealants in terms of retention, caries incidence and salivary fluoride release between two groups of children aged 6 and-8 years respectively. One hundred and ten first permanent molars were sealed and the clinical evaluation showed no incidence of caries. There was partial or complete retention of the sealant in 80% of the treated teeth in both groups at the one-year evaluation. Irrespective of the sealant used, the pattern of fluoride release remained consistent, with an initial high fluoride release followed by low prolonged leakage before returning to baseline value at the end of one year.

  1. MCDHF Calculations and Beam-Foil EUV Spectra of Boron-Like Sodium Ions (Na VII

    Directory of Open Access Journals (Sweden)

    Per Jönsson

    2015-06-01

    Full Text Available Atomic data, such as wavelengths and line identifications, are necessary for many applications, especially in plasma diagnostics and for interpreting the spectra of distant astrophysical objects. The number of valence shell electrons increases the complexity of the computational problem. We have selected a five-electron ion, Na6+ (with the boron-like spectrum Na VII, for looking into the interplay of measurement and calculation. We summarize the available experimental work, perform our own extensive relativistic configuration interaction (RCI computations based on multi-configuration Dirac–Hartree–Fock (MCDHF wave functions, and compare the results to what is known of the level structure. We then discuss problems with databases that have begun to combine observations and computations.

  2. Una lista de autores literarios en Plinio el Viejo: Naturalis Historia VII 107-117

    Directory of Open Access Journals (Sweden)

    Susana González Marín

    2003-06-01

    Full Text Available In NH VII 107-117 the Elder Pliny offers a selection of Greek and Roman notabilities who achieved prominence through their ingenium. This selection follows the model set by περὶ τεχνιτῶν treatises, especially Varro's De Poetis. Pliny's selection is based on two considerations: the glory achieved by each person; the opinions expressed by an authority, in most cases a politician. According to Pliny, the four Roman authors selected (Ennius, Virgil, Varro, Cicero served as paragons of excellence for the Roman people. Through his selection, Pliny defines his own attitude about the literary tradition and the intellectual elite in Rome: his idea of literature as a public service, the practical value of his work, his preference for prose and the increasingly strong influence exerted by experts on Roman Society.

  3. RESPONS SISWA KELAS VII TERHADAP PEMBELAJARAN TEKS LAPORAN HASIL OBSERVA SI DENGAN MEDIA VIDEO PENGETAHUAN

    Directory of Open Access Journals (Sweden)

    Nina Septia Rahmawati

    2017-08-01

    Full Text Available Learning Text Reports Observation with Media Video Knowledge has been implemented by one of Indonesion teachers in class in VII SMPN 19 Malang. To knows student responce on learning text reports observation with media video knowledge has been implemented, the student gived  Questionnaire. The purpose of the questionnaire is to determine the response of students to the use of video media knowledge in text learning reports the results of observation. The method used in this research is descriptive qualitative that is describe student response based on answer questionnaire. Based on the questionnaire responses from the four classes taught by the teacher concerned, it can be concluded that more students are claiming that the observational text of the observation report with the video media is good knowledge (B. There are also some minority students who stated quite well (C. The result of student questionnaire answers can be used as a reflection material for teachers to improve the quality of the next learning. Pembelajaran teks laporan observasi dengan media video pengetahuan telah dilaksanakan oleh salah satu guru Bahasa Indonesia di kelas VII SMPN 19 Malang. Untuk mengetahui respons siswa terhadap pembelajaran yang sudah dilakukan, siswa diberi angket. Tujuan dari pemberian angket tersebut adalah untuk mengetahui respons siswa terhadap penggunaan media video pengetahuan dalam pembelajaran teks laporan hasil observasi. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif yaitu mendeskripsikan respons siswa berdasarkan jawaban angket. Berdasarkan jawaban angket dari empat kelas yang diajar guru yang bersangkutan dapat disimpulkan bahwa lebih banyak siswa yang menyatakan bahwa pembelajaran teks laporan hasil observasi dengan media video pengetahuan baik (B. Ada juga beberapa minoritas siswa yang menyatakan cukup baik (C. Hasil jawaban angket siswa tersebut dapat dijadikan bahan refleksi bagi guru untuk meningkatkan kualitas

  4. Keefektifan Strategi Pembelajaran React Pada Kemampuan Siswa Kelas VII Aspek Komunikasi Matematis

    Directory of Open Access Journals (Sweden)

    A.T. Arifin

    2014-06-01

    Full Text Available AbstrakTujuan penelitian ini adalah mengetahui pembelajaran dengan strategi REACT efektif ter-hadap kemampuan komunikasi matematis siswa. Metode pengumpulan data dilakukan de-ngan metode dokumentasi, tes, dan observasi. Hasil uji proporsi menunjukkan bahwa hasil belajar siswa kelas eksperimen pada aspek kemampuan komunikasi matematis telah men-capai ketuntasan klasikal, mencapai lebih dari 80 % yaitu sebesar 96,7%. Dilihat dari nilai rata-rata tes kemampuan komunikasi matematis kelas eksperimen  adalah 83,61 sedangkan kelas kontrol adalah 73,79 dapat disimpulkan bahwa kemampuan komunikasi matematis siswa kelas eksperimen lebih baik daripada kemampuan komunikasi matematis siswa kon-trol. Hasil penelitian menunjukkan bahwa penerapan strategi pembelajaran REACT efektif terhadap kemampuan komunikasi matematis siswa materi segiempat kelas VII SMP Negeri 1 Gembong. Kata kunci:      keefektifan, kemampuan komunikasi matematis, Relating Experiencing Applying Cooperating Transferring (REACT  AbstractThe purpose of this study was to determine the effectiveness of the application of REACT learning strategy approach to mathematic communication ability of students. Methods of data collection is done by the method of documentation, testing, and observation. The test results showed that the proportion of student learning outcomes in the experimental class with the aspects of mathematic communication ability has reached the classical completeness, reached more than 80% is equal to 96.7%. Judging from the value of the average test learners' ability to mathematic communication experimental class was 83.61 while the control class is 73.79 it can be concluded that the mathematic communication skills of learners experimental classes are better than mathematic communication abilities of learners control class. The results showed that the application of REACT learning strategy approach effective to mathematic communication abilities of students of class VII

  5. PENGEMBANGAN PERANGKAT PEMBELAJARAN ARITMETIKA SOSIAL BERBASIS PROBLEM BASED LEARNING DI KELAS VII SMP

    Directory of Open Access Journals (Sweden)

    Ruslan Ridwan

    2016-07-01

    Full Text Available The purpose of this study is aimeds to (1 produce the mathematics lesson plan based on social arithmetic Problem Based Learning (PBL in class VII in viewed from the aspects of validity and practicality and to know the potential effects arising from the development of the lesson plan, (2 describe the characteristics of the lesson plan based on social arithmetic Problem Based Learning. The method of the study was the development research according to the type of formative research by Tessmer. The stages of development were  Self Evaluation, prototyping and product. The subjects were VII.1 grade students of SMP Negeri 1 Muaradua semester 2014/2015 academic year, consistive of 31 people. Data collection techniques used were documentation, walk-throughs, observation sheets, and test results. Data were analyzed qualitatively and quantitatively. The results of data analysis showed that in the mathematics lesson plan based on social arimetika Problem Based Learning (PBL were valid, practical, and had a potential effect. The lesson plan had a valid learning in the content, construct, and language experts based on the results of the validation stage of the expert review and the prototype  test on a small group stage, while the practical lesson plan obtained  from the revised test results of one-to-one and small group. Potential effects of the lesson plan was  known from the results of the field test and the results of the student's final test. The results of the student's final test showed 45.16% of the students were is very good category, 32.26%  were  good category, and 22.58% fair category. From the result of observation, the percentage average of students’ activity was above 81,25% included in very good category.

  6. Title VII and the development and promotion of national initiatives in training primary care clinicians in the United States.

    Science.gov (United States)

    Davis, Ardis K; Reynolds, P Preston; Kahn, Norman B; Sherwood, Roger A; Pascoe, John M; Goroll, Allan H; Wilson, Modena E H; DeWitt, Thomas G; Rich, Eugene C

    2008-11-01

    The Title VII, Section 747 (Title VII) legislation, which authorizes the Training in Primary Care Medicine and Dentistry grant program, provides statutory authority to the Health Resources and Services Administration (HRSA) to award contracts and cooperative agreements aimed at enhancing the quality of primary care training in the United States.More than 35 contracts and cooperative agreements have been issued by HRSA with Title VII federal funds, most often to national organizations promoting the training of physician assistants and medical students and representing the primary care disciplines of family medicine, general internal medicine, and general pediatrics. These activities have influenced generalist medicine through three mechanisms: (1) building collaboration among the primary care disciplines and between primary care and specialty medicine, (2) strengthening primary care generally through national initiatives designed to develop and implement new models of primary care training, and (3) enhancing the quality of primary care training in specific disease areas determined to be of national importance.The most significant outcomes of the Title VII contracts awarded to national primary care organizations are increased collaboration and enhanced innovation in ambulatory training for students, residents, and faculty. Overall, generalist competencies and education in new content areas have been the distinguishing features of these initiatives. This effort has enhanced not only generalist training but also the general medical education of all students, including future specialists, because so much of the generalist competency agenda is germane to the general medical education mission.This article is part of a theme issue of Academic Medicine on the Title VII health professions training programs.

  7. Large proteoglycan complexes and disturbed collagen architecture in the corneal extracellular matrix of mucopolysaccharidosis type VII (Sly syndrome).

    Science.gov (United States)

    Young, Robert D; Liskova, Petra; Pinali, Christian; Palka, Barbara P; Palos, Michalis; Jirsova, Katerina; Hrdlickova, Enkela; Tesarova, Marketa; Elleder, Milan; Zeman, Jiri; Meek, Keith M; Knupp, Carlo; Quantock, Andrew J

    2011-08-24

    Deficiencies in enzymes involved in proteoglycan (PG) turnover underlie a number of rare mucopolysaccharidoses (MPS), investigations of which can considerably aid understanding of the roles of PGs in corneal matrix biology. Here, the authors analyze novel pathologic changes in MPS VII (Sly syndrome) to determine the nature of PG-collagen associations in stromal ultrastructure. Transmission electron microscopy and electron tomography were used to investigate PG-collagen architectures and interactions in a cornea obtained at keratoplasty from a 22-year-old man with MPS VII, which was caused by a compound heterozygous mutation in the GUSB gene. Transmission electron microscopy showed atypical morphology of the epithelial basement membrane and Bowman's layer in MPS VII. Keratocytes were packed with cytoplasmic vacuoles containing abnormal glycosaminoglycan (GAG) material, and collagen fibrils were thinner than in normal cornea and varied considerably throughout anterior (14-32 nm), mid (13-42 nm), and posterior (17-39 nm) regions of the MPS VII stroma. PGs viewed in three dimensions were striking in appearance in that they were significantly larger than PGs in normal cornea and formed highly extended linkages with multiple collagen fibrils. Cellular changes in the MPS VII cornea resemble those in other MPS. However, the wide range of collagen fibril diameters throughout the stroma and the extensive matrix presence of supranormal-sized PG structures appear to be unique features of this disorder. The findings suggest that the accumulation of stromal chondroitin-, dermatan-, and heparan-sulfate glycosaminoglycans in the absence of β-glucuronidase-mediated degradation can modulate collagen fibrillogenesis.

  8. A novel GUSB mutation in Brazilian terriers with severe skeletal abnormalities defines the disease as mucopolysaccharidosis VII.

    Directory of Open Access Journals (Sweden)

    Marjo K Hytönen

    Full Text Available Hundreds of different human skeletal disorders have been characterized at molecular level and a growing number of resembling dysplasias with orthologous genetic defects are being reported in dogs. This study describes a novel genetic defect in the Brazilian Terrier breed causing a congenital skeletal dysplasia. Affected puppies presented severe skeletal deformities observable within the first month of life. Clinical characterization using radiographic and histological methods identified delayed ossification and spondyloepiphyseal dysplasia. Pedigree analysis suggested an autosomal recessive disorder, and we performed a genome-wide association study to map the disease locus using Illumina's 22K SNP chip arrays in seven cases and eleven controls. A single association was observed near the centromeric end of chromosome 6 with a genome-wide significance after permutation (p(genome= 0.033. The affected dogs shared a 13-Mb homozygous region including over 200 genes. A targeted next-generation sequencing of the entire locus revealed a fully segregating missense mutation (c.866C>T causing a pathogenic p.P289L change in a conserved functional domain of β-glucuronidase (GUSB. The mutation was confirmed in a population of 202 Brazilian terriers (p = 7,71×10(-29. GUSB defects cause mucopolysaccharidosis VII (MPS VII in several species and define the skeletal syndrome in Brazilian Terriers. Our results provide new information about the correlation of the GUSB genotype to phenotype and establish a novel canine model for MPS VII. Currently, MPS VII lacks an efficient treatment and this model could be utilized for the development and validation of therapeutic methods for better treatment of MPS VII patients. Finally, since almost one third of the Brazilian terrier population carries the mutation, breeders will benefit from a genetic test to eradicate the detrimental disease from the breed.

  9. Contaminant discharge in habitat springs of the Barton Springs Salamander during storm rainfall events

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Aquatic habitat of the endangered Barton Springs salamander, Eurycea sosorum, in Travis County, Texas can potentially be impacted by contaminants in surface runoff...

  10. A springs actuated finger exoskeleton: From mechanical design to spring variables evaluation.

    Science.gov (United States)

    Bortoletto, Roberto; Mello, Ashley N; Piovesan, Davide

    2017-07-01

    In the context of post-stroke patients, suffering of hemiparesis of the hand, robot-aided neuro-motor rehabilitation allows for intensive rehabilitation treatments and quantitative evaluation of patients' progresses. This work presents the design and evaluation of a spring actuated finger exoskeleton. In particular, the spring variables and the interaction forces between the assembly and the hand were investigated, in order to assess the effectiveness of the proposed exoskeleton.

  11. THE SPRING OF THE NETWORKED NATIONS: SOCIAL MEDIA AND THE ARAB SPRING

    Directory of Open Access Journals (Sweden)

    Harel Chorev

    2012-12-01

    Full Text Available This essay argues that social media played an important role in the Arab Spring and contributed to a change in the political culture of some of those countries that have gone through regime-change through 2011-2012. The article further posits that the contribution of social media was mainly instrumental, not causal, and that the main reasons behind the Arab Spring were problems generated by regional, local and global trends, affecting each country differently.

  12. Type VII Collagen is Enriched in the Enamel Organic Matrix Associated with the Dentin-Enamel Junction of Mature Human Teeth

    Science.gov (United States)

    McGuire, Jacob D.; Walker, Mary P.; Mousa, Ahmad; Wang, Yong; Gorski, Jeff P.

    2014-01-01

    The inner enamel region of erupted teeth is known to exhibit higher fracture toughness and crack growth resistance than bulk phase enamel. However, an explanation for this behavior has been hampered by the lack of compositional information for the residual enamel organic matrix. Since enamel-forming ameloblasts are known to express type VII collagen and type VII collagen null mice display abnormal amelogenesis, the aim of this study was to determine whether type VII collagen is a component of the enamel organic matrix at the dentin-enamel junction (DEJ) of mature human teeth. Immunofluorescent confocal microscopy of demineralized tooth sections localized type VII collagen to the organic matrix surrounding individual enamel rods near the DEJ. Morphologically, immunoreactive type VII collagen helical-bundles resembled the gnarled-pattern of enamel rods detected by Coomassie Blue staining. Western blotting of whole crown or enamel matrix extracts also identified characteristic Mr=280 and 230 kDa type VII dimeric forms, which resolved into 75 and 25 kDa bands upon reduction. As expected, the collagenous domain of type VII collagen was resistant to pepsin digestion, but was susceptible to purified bacterial collagenase. These results demonstrate the inner enamel organic matrix in mature teeth contains macromolecular type VII collagen. Based on its physical association with the DEJ and its well-appreciated capacity to complex with other collagens, we hypothesize that enamel embedded type VII collagen fibrils may contribute not only to the structural resilience of enamel, but may also play a role in bonding enamel to dentin. PMID:24594343

  13. Quaternary geology of Fish Springs flat, Juab county, Utah

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Fish Springs Flat is a sediment-filled valley between two tilted mountain blocks, the Thomas Range and the Fish Springs Range, in the Basin and Range physiographic...

  14. Archaeological resources of Fish Springs National Wildlife Refuge: Preliminary report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document presents results of an archeological survey of two caves located in the Fish Springs National Wildlife Refuge. It was concluded that the Fish Springs...

  15. Initial Survey Instructions for Spring Water Monitoring : Flow

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Initial survey instructions for the Spring Water Monitoring - Flow 1.02 survey at Fish Springs National Wildlife Refuge. This coop baseline monitoring survey has...

  16. Initial Survey Instructions for Spring Water Monitoring : Quality

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Initial survey instructions for 1.04 spring water monitoring (quality) and 1.06 management unit water monitoring (quality) at Fish Springs National Wildlife Refuge....

  17. Archaeal diversity in Icelandic hot springs

    DEFF Research Database (Denmark)

    Kvist, Thomas; Ahring, Birgitte Kiær; Westermann, Peter

    2007-01-01

    of Archaea by analysis of amplified 16S rRNA genes. In addition to the three solfataras and the neutral hot spring, 10 soil samples in transects of the soil adjacent to the solfataras were analysed using terminal restriction fragment length polymorphism (t-RFLP). The sequence data from the clone libraries...... in combination with 14 t-RFLP profiles revealed a high abundance of clones clustering together with sequences from the nonthermophilic I.1b group of Crenarchaeota. The archaeal diversity in one solfatara was high; 26 different RFLP patterns were found using double digestion of the PCR products with restriction......Whole-cell density gradient extractions from three solfataras (pH 2.5) ranging in temperature from 81 to 90 degrees C and one neutral hot spring (81 degrees C, pH 7) from the thermal active area of Hveragerethi (Iceland) were analysed for genetic diversity and local geographical variation...

  18. A Lagrangian View of Spring Phytoplankton Blooms

    Science.gov (United States)

    Kida, Shinichiro; Ito, Takamitsu

    2017-11-01

    The mechanisms of spring phytoplankton blooms are investigated from a Lagrangian framework by using a Lagrangian NPZD model that can track the movement and transfers of nutrient parcels in a turbulent environment. The model reveals that the onset of spring blooms depends on the cumulative euphotic age, which is the total time that inorganic nutrient is exposed to light before the photosynthetic conversion to phytoplankton biomass. A spring bloom, defined as a tenfold increase of near-surface phytoplankton, occurs when this cumulative euphotic age is approximately μeff-1·ln⁡10, where μeff is the effective growth rate in the euphotic layer, regardless of the underlying mechanism. If the turbulent layer depth is shallower than the critical depth and turbulence is strong, nutrient parcels accumulate enough light exposure through multiple entries to the sun-lit zone near the surface. If turbulence is weak, as that considered in the critical turbulence theory, the accumulation of the light exposure depends on the residence time of the nutrients parcels near the surface. The spectral shape of the cumulative euphotic age can clearly distinguish these two modes of spring blooms. The spectrum shows a peak at the theoretical growth timescale when multiple entries become important, while it shows a maximum near age zero that decays with age when the near-surface residence time becomes important. Mortality increases the cumulative euphotic age necessary for a bloom but does not affect the spectral shape, suggesting that it does not alter the primary mechanism behind the accumulation of cumulative euphotic age.

  19. Spring bloom onset in the Nordic Seas

    Science.gov (United States)

    Mignot, Alexandre; Ferrari, Raffaele; Mork, Kjell Arne

    2016-06-01

    The North Atlantic spring bloom is a massive annual growth event of marine phytoplankton, tiny free-floating algae that form the base of the ocean's food web and generates a large fraction of the global primary production of organic matter. The conditions that trigger the onset of the spring bloom in the Nordic Seas, at the northern edge of the North Atlantic, are studied using in situ data from six bio-optical floats released north of the Arctic Circle. It is often assumed that spring blooms start as soon as phytoplankton cells daily irradiance is sufficiently abundant that division rates exceed losses. The bio-optical float data instead suggest the tantalizing hypothesis that Nordic Seas blooms start when the photoperiod, the number of daily light hours experienced by phytoplankton, exceeds a critical value, independently of division rates. The photoperiod trigger may have developed at high latitudes where photosynthesis is impossible during polar nights and phytoplankton enters into a dormant stage in winter. While the first accumulation of biomass recorded by the bio-optical floats is consistent with the photoperiod hypothesis, it is possible that some biomass accumulation started before the critical photoperiod but at levels too low to be detected by the fluorometers. More precise observations are needed to test the photoperiod hypothesis.

  20. N Springs expedited response action proposal

    Energy Technology Data Exchange (ETDEWEB)

    1994-01-01

    Since signing the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement) in 1989, the parties to the agreement have recognized the need to modify the approach to conducting investigations, studies, and cleanup actions at Hanford. To implement this approach, the parties have jointly developed the Hanford Past-Practice Strategy. The strategy defines a non-time-critical expedited response action (ERA) as a response action ``needed to abate a threat to human health or welfare or the environment where sufficient time exists for formal planning prior to initiation of response. In accordance with the past-practice strategy, DOE proposes to conduct an ERA at the N Springs, located in the Hanford 100 N Area, to substantially reduce the strontium-90 transport into the river through the groundwater pathway. The purpose of this ERA proposal is to provide sufficient information to select a preferred alternative at N Springs. The nature of an ERA requires that alternatives developed for the ERA be field ready; therefore, all the technologies proposed for the ERA should be capable of addressing the circumstances at N Springs. A comparison of these alternatives is made based on protectiveness, cost, technical feasibility, and institutional considerations to arrive at a preferred alternative. Following the selection of an alternative, a design phase will be conducted; the design phase will include a detailed look at design parameters, performance specifications, and costs of the selected alternative. Testing will be conducted as required to generate design data.

  1. Rain-induced spring wheat harvest losses

    Science.gov (United States)

    Bauer, A.; Black, A. L. (Principal Investigator)

    1983-01-01

    When rain or a combination of rain and high humidity delay wheat harvest, losses can occur in grain yield and/or grain quality. Yield losses can result from shattering, from reduction in test weight, and in the case of windrowed grain, from rooting of sprouting grain at the soil: windrow contact. Losses in grain quality can result from reduction in test weight and from sprouting. Sprouting causes a degradation of grain proteins and starches, hence flour quality is reduced, and the grain price deteriorates to the value of feed grain. Although losses in grain yield and quality are rain-induced, these losses do not necessarily occur because a standing or windrowed crop is wetted by rain. Spike water concentration in hard red spring wheat must be increased to about 45-49% before sprouting is initiated in grain that has overcome dormancy. The time required to overcome this dormancy after the cultivar has dried to 12 to 14% water concentration differs with hard red spring cultivars. The effect of rain on threshing-ready standing and windrowed hard red spring wheat grain yeild and quality was evaluated. A goal was to develop the capability to forecast the extent of expected loss of grain yield and quality from specific climatic events that delay threshing.

  2. 49 CFR 213.139 - Spring rail frogs.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Spring rail frogs. 213.139 Section 213.139..., DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Track Structure § 213.139 Spring rail frogs. (a) The outer edge of a wheel tread shall not contact the gage side of a spring wing rail. (b) The toe of each...

  3. Thermal and chemical characteristics of hot water springs in the ...

    African Journals Online (AJOL)

    2011-02-15

    Feb 15, 2011 ... Keywords: thermal springs, South Africa, macro and micro-elements, geological controls. Introduction. A spring is .... features of the study areas in view of their impact on the physi- cal location of the springs and on .... rating the resultant solutions over open fires in clay pots' (Kent,. 1942: 35). According to ...

  4. The order-chaos-order sequence in the spring pendulum

    NARCIS (Netherlands)

    van der Weele, J.P.; de Kleine, Elian

    1996-01-01

    We study the motions of a spring pendulum as a function of its two control parameters (the ratio of the spring and pendulum frequencies, and the energy). It is shown that in the limits for very small and very large parameter values the dynamics of the spring pendulum is predominantly regular, while

  5. Hydrochemical Characteristics of Springs in Oke–Igbo, Ondo State ...

    African Journals Online (AJOL)

    ... parameter in which high coliform colonies were observed at the lower courses of each spring. The pH of the springs was generally low ranging from slightly acidic to acidic. The presence of bacteria count and Escherichia coli in the springs' water indicated fecal pollution, which could result in related water-borne diseases.

  6. Use of thermal springs for geochemical exploration in Ethiopia ...

    African Journals Online (AJOL)

    Hence, hot spring water anomalous in Au, Mn, Zn, Pb, Cu, Co and Ag could be a proxy for precious metal searching in epithermal systems associated with thermal springs. Keywords: Epithermal system, Ethiopian Rift Valley, geochemical exploration, thermal springs. Ethiopian Journal of Environmental Studies and ...

  7. Microbiological and chemical assessment of spring water from a ...

    African Journals Online (AJOL)

    GREG

    2013-06-20

    Jun 20, 2013 ... Assessment of spring water from Ikare-Akoko, a rural setting in southwest, Nigeria for microbial and chemical contaminants ... Key words: Rural setting, spring water, heterotrophic bacteria, coliform bacteria, physico-chemical properties, ..... logical quality of spring water depends on the source rock and how ...

  8. Thermal and chemical characteristics of hot water springs in the ...

    African Journals Online (AJOL)

    The temperatures at source vary from 30°C to 67.5°C. The springs are associated with faults and impermeable dykes and are assumed to be of meteoric origin. The mineral composition of the ... the ultimate use of the thermal springs. Keywords: thermal springs, South Africa, macro and micro-elements, geological controls ...

  9. Utilities:Water:Spring Water Lines at Pipe Spring National Monument, Arizona (Utilities.gdb:Water:springwtr)

    Data.gov (United States)

    National Park Service, Department of the Interior — This feature class represents spring water lines at Pipe Spring National Monument, Arizona. The data were collected using Trimble Global Positioning System (GPS)...

  10. Springs as Ecosystems: Clarifying Groundwater Dependence and Wetland Status (Invited)

    Science.gov (United States)

    Stevens, L.; Springer, A. E.; Ledbetter, J. D.

    2013-12-01

    Springs ecosystems are among the most productive, biologically diverse and culturally important ecosystems on Earth. Net annual productivity of some springs exceeds 5 kg/m^2/yr. Springs support an estimated 19% of the endangered species and numerous rare taxa in the United States. Springs serve as keystone ecosystems in arid regions, and as cornerstones of indigenous cultural well-being, history, economics, and aesthetics. Despite their significance, the ecosystem ecology and stewardship of springs have received scant scientific and public attention, resulting in loss or impairment of 50-90% of the springs in many regions, both arid and temperate. Six reasons contribute to the lack of attention to springs. Springs are poorly mapped because: 1) their generally small size is less than the pixel area of most remote sensing analyses and they are overlooked; and 2) springs detection is often limited by emergence on cliff faces, beneath heavy vegetation cover, or under water. In addition, 3) high levels of ecosystem complexity at springs require multidisciplinary team approaches for inventory, assessment, and research, but collaboration between the fields of hydrogeology and ecology has been limited. 4) Protectionism by land owners and organizations that manage springs limits the availability information, preventing regional assessment of status. 5) Prior to recent efforts, the absence of a descriptive lexicon of springs types has limited discussion about variation in ecological characteristics and processes. 6) Neither regarded entirely as groundwater or as surface water, springs fall 'between jurisdictional cracks' and are not subject to clear legal and regulatory oversight. With regards to the latter point, two jurisdictional phrases have reduced scientific understanding and stewardship of springs ecosystems: 'jurisdictional wetlands' and 'groundwater-dependent ecosystems' (GDEs). Most springs have insufficient monitoring data to establish perenniality or the range of

  11. Integrated Field Analyses of Thermal Springs

    Science.gov (United States)

    Shervais, K.; Young, B.; Ponce-Zepeda, M. M.; Rosove, S.

    2011-12-01

    A group of undergraduate researchers through the SURE internship offered by the Southern California Earthquake Center (SCEC) have examined thermal springs in southern Idaho, northern Utah as well as mud volcanoes in the Salton Sea, California. We used an integrated approach to estimate the setting and maximum temperature, including water chemistry, Ipad-based image and data-base management, microbiology, and gas analyses with a modified Giggenbach sampler.All springs were characterized using GISRoam (tmCogent3D). We are performing geothermometry calculations as well as comparisons with temperature gradient data on the results while also analyzing biological samples. Analyses include water temperature, pH, electrical conductivity, and TDS measured in the field. Each sample is sealed and chilled and delivered to a water lab within 12 hours.Temperatures are continuously monitored with the use of Solinst Levelogger Juniors. Through partnership with a local community college geology club, we receive results on a monthly basis and are able to process initial data earlier in order to evaluate data over a longer time span. The springs and mudpots contained microbial organisms which were analyzed using methods of single colony isolation, polymerase chain reaction, and DNA sequencing showing the impact of the organisms on the springs or vice versa. Soon we we will collect gas samples at sites that show signs of gas. This will be taken using a hybrid of the Giggenbach method and our own methods. Drawing gas samples has proven a challenge, however we devised a method to draw out gas samples utilizing the Giggenbach flask, transferring samples to glass blood sample tubes, replacing NaOH in the Giggenbach flask, and evacuating it in the field for multiple samples using a vacuum pump. We also use a floating platform devised to carry and lower a levelogger, to using an in-line fuel filter from a tractor in order to keep mud from contaminating the equipment.The use of raster

  12. Assessment of spring cranioplasty biomechanics in sagittal craniosynostosis patients.

    Science.gov (United States)

    Borghi, Alessandro; Schievano, Silvia; Rodriguez Florez, Naiara; McNicholas, Roisin; Rodgers, Will; Ponniah, Allan; James, Greg; Hayward, Richard; Dunaway, David; Jeelani, N U Owase

    2017-11-01

    OBJECTIVE Scaphocephaly secondary to sagittal craniosynostosis has been treated in recent years with spring-assisted cranioplasty, an innovative approach that leverages the use of metallic spring distractors to reshape the patient skull. In this study, a population of patients who had undergone spring cranioplasty for the correction of scaphocephaly at the Great Ormond Street Hospital for Children was retrospectively analyzed to systematically assess spring biomechanical performance and kinematics in relation to spring model, patient age, and outcomes over time. METHODS Data from 60 patients (49 males, mean age at surgery 5.2 ± 0.9 months) who had received 2 springs for the treatment of isolated sagittal craniosynostosis were analyzed. The opening distance of the springs at the time of insertion and removal was retrieved from the surgical notes and, during the implantation period, from planar radiographs obtained at 1 day postoperatively and at the 3-week follow-up. The force exerted by the spring to the patient skull at each time point was derived after mechanical testing of each spring model-3 devices with the same geometry but different wire thicknesses. Changes in the cephalic index between preoperatively and the 3-week follow-up were recorded. RESULTS Stiffer springs were implanted in older patients (p springs were used (p spring models, however, the devices all plateaued. Indeed, regardless of patient age or spring model, after 10 days from insertion, all the devices were open. CONCLUSIONS Results in this study provide biomechanical insights into spring-assisted cranioplasty and could help to improve spring design and follow-up strategy in the future.

  13. Two decades of Title VII support of a primary care residency: process and outcomes.

    Science.gov (United States)

    Lipkin, Mack; Zabar, Sondra R; Kalet, Adina L; Laponis, Ryan; Kachur, Elizabeth; Anderson, Marian; Gillespie, Colleen C

    2008-11-01

    To assess 23 years of Health Resources and Services Administration (HRSA) Title VII Training in Primary Care Medicine and Dentistry funding to the New York University School of Medicine/Bellevue Primary Care Internal Medicine Residency Program. The program, begun in 1983 within a traditional, inner-city, subspecialty-oriented internal medicine program, evolved into a crucible of systematic innovation, catalyzed and made feasible by initiatives funded by the HRSA. The curriculum stressed three pillars of generalism: psychosocial medicine, clinical epidemiology, and health policy. It developed tight, objectives-driven, effective, nonmedical specialty blocks and five weekly primary care activities that created a paradigm-driven, community-based, role-modeling matrix. Innovation was built in. Every block and activity was evaluated immediately and in an annual, program-wide retreat. Evaluation evolved from behavioral checklists of taped interviews to performance-based, systematic, annual objective structured clinical examinations. The authors reviewed eight grant proposals, project reports, and curriculum and program evaluations. They also quantitatively and qualitatively surveyed the 122 reachable graduates from the first 20 graduating classes of the program. Analysis of program documents revealed recurring emphases on the use of proven educational models, strategic innovation, and assessment and evaluation to design and refine the program. There were 104 respondents (85%) to the survey. A total of 87% of the graduates practice as primary care physicians, 83% teach, and 90% work with the underserved; 54% do research, 36% actively advocate on health issues for their patients, programs, and other constituencies, and 30% publish. Graduates cited work in the community and faculty excitement and energy as essential elements of the program's impact; overall, graduates reported high personal and career satisfaction and low burnout. With HRSA support, a focused, innovative

  14. ENDF/B-VII.0: Next Generation Evaluated Nuclear Data Library for Nuclear Science and Technology

    Energy Technology Data Exchange (ETDEWEB)

    Chadwick, M B; Oblozinsky, P; Herman, M; Greene, N M; McKnight, R D; Smith, D L; Young, P G; MacFarlane, R E; Hale, G M; Haight, R C; Frankle, S; Kahler, A C; Kawano, T; Little, R C; Madland, D G; Moller, P; Mosteller, R; Page, P; Talou, P; Trellue, H; White, M; Wilson, W B; Arcilla, R; Dunford, C L; Mughabghab, S F; Pritychenko, B; Rochman, D; Sonzogni, A A; Lubitz, C; Trumbull, T H; Weinman, J; Brown, D; Cullen, D E; Heinrichs, D; McNabb, D; Derrien, H; Dunn, M; Larson, N M; Leal, L C; Carlson, A D; Block, R C; Briggs, B; Cheng, E; Huria, H; Kozier, K; Courcelle, A; Pronyaev, V; der Marck, S

    2006-10-02

    We describe the next generation general purpose Evaluated Nuclear Data File, ENDF/B-VII.0, of recommended nuclear data for advanced nuclear science and technology applications. The library, released by the U.S. Cross Section Evaluation Working Group (CSEWG) in December 2006, contains data primarily for reactions with incident neutrons, protons, and photons on almost 400 isotopes. The new evaluations are based on both experimental data and nuclear reaction theory predictions. The principal advances over the previous ENDF/B-VI library are the following: (1) New cross sections for U, Pu, Th, Np and Am actinide isotopes, with improved performance in integral validation criticality and neutron transmission benchmark tests; (2) More precise standard cross sections for neutron reactions on H, {sup 6}Li, {sup 10}B, Au and for {sup 235,238}U fission, developed by a collaboration with the IAEA and the OECD/NEA Working Party on Evaluation Cooperation (WPEC); (3) Improved thermal neutron scattering; (4) An extensive set of neutron cross sections on fission products developed through a WPEC collaboration; (5) A large suite of photonuclear reactions; (6) Extension of many neutron- and proton-induced reactions up to an energy of 150 MeV; (7) Many new light nucleus neutron and proton reactions; (8) Post-fission beta-delayed photon decay spectra; (9) New radioactive decay data; and (10) New methods developed to provide uncertainties and covariances, together with covariance evaluations for some sample cases. The paper provides an overview of this library, consisting of 14 sublibraries in the same, ENDF-6 format, as the earlier ENDF/B-VI library. We describe each of the 14 sublibraries, focusing on neutron reactions. Extensive validation, using radiation transport codes to simulate measured critical assemblies, show major improvements: (a) The long-standing underprediction of low enriched U thermal assemblies is removed; (b) The {sup 238}U, {sup 208}Pb, and {sup 9}Be reflector

  15. Komparasi Kemampuan Berpikir Kritis pada Pembelajaran Group Investigation dan Guided Discovery Berbasis Portofolio Siswa Kelas VII

    Directory of Open Access Journals (Sweden)

    Endah Yuli Astuti

    2015-10-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui rata-rata kemampuan berpikir kritis siswa antara kelas yang dikenai model pembelajaran Group Investigation dan kelas yang dikenai model pembelajaran Guided Discovery yang berbasis portofolio dalam penilaian. Populasi dalam penelitian ini adalah siswa kelas VII SMP Negeri 3 Magelang tahun pelajaran 2013/2014. Sampel diambil dengan teknik Cluster Random Sampling. Pengumpulan data dilakukan dengan menggunakan metode tes. Analisis data menggunakan:(1 Uji t pihak kanan, untuk menguji tingkat ketuntasan individual; (2 Uji z, untuk menguji tingkat ketuntasan klasikal; dan (3 Uji t perbedaan rata-rata, untuk menguji perbedaan rata-rata kemampuan berpikir kritis siswa antara kelas dengan model pembelajaran Group Investigation dan kelas dengan model pembelajaran Guided Discovery berbasis portofolio. Hasil penelitian menunjukkan bahwa: (1 pembelajaran dengan model Group Investigation berbasis portofolio telah mencapai ketuntasan belajar secara individual maupun secara klasikal; (2 pembelajaran dengan model Guided Discovery berbasis portofolio telah mencapai ketuntasan belajar secara individual maupun secara klasikal; (3 rata-rata kemampuan berpikir kritis siswa dengan model pembelajaran Guided Discovery berbasis portofolio lebih baik dari rata-rata kemapuan berpikir kritis siswa dengan model pembelajaran Group Investigation berbasis portofolio.The purposes of this study are to find out the average competence of student’s critical thinking skills between the Group Investigation and Guided Discovery base on portfolio. The population of this study is students of VII grades of junior high school 3 Magelang, by using Cluster Random Sampling. The data collecting by using test method. The data analyses are using: (1 T test of right side, to examine the level of individual minimum score competeness; (2 Z test, to examine the level of classical minimum score competeness; (3 T test the difference of average, to examine the

  16. Isolation of a Membrane Protein Complex for Type VII Secretion in Staphylococcus aureus.

    Science.gov (United States)

    Aly, Khaled A; Anderson, Mark; Ohr, Ryan Jay; Missiakas, Dominique

    2017-12-01

    The ESAT6-like secretion system (ESS) of Staphylococcus aureus promotes effector protein transport across the bacterial envelope. Genes in the ESS cluster are required for S. aureus establishment of persistent abscess lesions and the modulation of immune responses during bloodstream infections. However, the biochemical functions of most of the ESS gene products, specifically the identity of secretion machine components, are unknown. Earlier work demonstrated that deletion of essB, which encodes a membrane protein, abolishes S. aureus ESS secretion. Loss-of-function mutations truncating the essB gene product cause dominant-negative phenotypes on ESS secretion, suggesting that EssB is a central component of the secretion machinery. To test this prediction, we purified native and affinity-tagged EssB from staphylococcal membranes via dodecyl-maltoside extraction, identifying a complex assembled from five proteins, EsaA, EssA, EssB, EssD, and EsxA. All five proteins are essential for secretion, as knockout mutations in the corresponding genes abolish ESS transport. Biochemical and bacterial two-hybrid analyses revealed a direct interaction between EssB and EsaA that, by engaging a mobile machine component, EsxA, may also recruit EssA and EssD.IMPORTANCE Type VII secretion systems support the lifestyle of Gram-positive bacteria, including important human pathogens such as Bacillus anthracis, Mycobacterium tuberculosis, and Staphylococcus aureus Genes encoding SpoIIIE-FtsK-like ATPases and WXG100-secreted products are conserved features of type VII secretion pathways; however, most of the genes in T7SS clusters are not conserved between different bacterial species. Here, we isolate a complex of proteins from the membranes of S. aureus that appears to represent the core secretion machinery, designated ESS. These results suggest that three membrane proteins, EsaA, EssB, and EssA, form a secretion complex that associates with EssC, the SpoIIIE-FtsK-like ATPase, and with Esx

  17. PENGARUH KEMANDIRIAN BELAJAR DAN PENGGUNAAN UANG SAKU TERHADAP PRESTASI BELAJAR KOMPETENSI DASAR EKONOMI KELAS VII DAN VIII

    Directory of Open Access Journals (Sweden)

    Apri Dwi Astuti

    2012-10-01

    Full Text Available Kemandirian belajar membantu siswa untuk bertanggung jawab dan menumbuhkan kesadaran belajar. Penggunaan uang saku menumbuhkan jiwa mandiri, jujur dan komitmen. Adapun hasil observasi awal menunjukkan masih ada siswa kels VII dan VIII SMP Semesta untuk kompetensi dasar ekonomi dibawah KKM. Tujuan penelitian ini untuk mengetahui pengaruh kemandirian belajar dn penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta. Populasi penelitian ini adalah semua siswa kelas VII dan VIII SMP Semesta Boarding School Semarang. Variabel penelitian ini adalah kemandirian belajar dan penggunaan uang saku sebagai variabel bebas, sedangkan untuk� variabel terikat adalah prestasi belajar kompetensi dasar ekonomi. Data diambil dengan metode wawancara, kuesioner dan dokumentasi guru. Analisis data menggunakan analisis regresi linear berganda.Berdasarkan penelitian secara simultan menunjukkan adanya pengaruh antara kemandirian belajar dan penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi sebesar 51,3%. Secara parsial, pengaruh kemandirian belajar terhadap prestasi belajar kompetensi dasar ekonomi sebesar 66,2% dan pengaruh penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi sebesar 62,5%.Berdasarkan hasil penelitian diatas disimpulkan bahwa kemandirian belajar dan penggunaan uang saku berpengaruh positif baik secara simultan maupun parsial terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta Boarding school semarang tahun pelajaran 2011/2012. Saran yang berkaitan dengan penelitian ini yaitu : 1 Sekolah disarankan untuk memberikan batasan siswa pulang ke rumah agar dapat membantu siswa beradaptasi dengan cepat dan mudah tinggal di asrama. 2 Orang tua disarankan untuk memberikan uang saku yang disesuaikan dengan kebutuhan siswa. 3 Siswa disarankan untuk meningkatkan kemandirian dalam aspek belajar terutama bagi mata pelajaran yang masih kurang dari

  18. High Dose, Prolonged Epsilon Aminocaproic Acid Infusion, and Recombinant Factor VII for Massive Postoperative Retroperitoneal Hemorrhage following Splenectomy

    Directory of Open Access Journals (Sweden)

    Alex T. Lee

    2016-01-01

    Full Text Available The antifibrinolytic agent ε-aminocaproic acid is used to decrease procedural blood loss in a variety of high risk surgeries. The utility of recombinant factor VII administration in massive hemorrhage has also been reported in a variety of settings, though the impact in a surgical context remains unclear. We describe the case of a patient who underwent massive open splenectomy and developed diffuse retroperitoneal bleeding on postoperative day one. Massive transfusion was initiated, but attempts to control hemorrhage with surgical and interventional radiology approaches were unsuccessful, as was recombinant factor VII administration. Commencement of a high dose aminocaproic acid infusion was followed by a prominent rise in fibrinogen levels and stabilization of the hemorrhage. Indications, dosages, and adverse effects of ε-aminocaproic acid as described in the literature are reviewed.

  19. High Dose, Prolonged Epsilon Aminocaproic Acid Infusion, and Recombinant Factor VII for Massive Postoperative Retroperitoneal Hemorrhage following Splenectomy.

    Science.gov (United States)

    Lee, Alex T; Barnes, Christopher R; Jain, Shweta; Pauldine, Ronald

    2016-01-01

    The antifibrinolytic agent ε -aminocaproic acid is used to decrease procedural blood loss in a variety of high risk surgeries. The utility of recombinant factor VII administration in massive hemorrhage has also been reported in a variety of settings, though the impact in a surgical context remains unclear. We describe the case of a patient who underwent massive open splenectomy and developed diffuse retroperitoneal bleeding on postoperative day one. Massive transfusion was initiated, but attempts to control hemorrhage with surgical and interventional radiology approaches were unsuccessful, as was recombinant factor VII administration. Commencement of a high dose aminocaproic acid infusion was followed by a prominent rise in fibrinogen levels and stabilization of the hemorrhage. Indications, dosages, and adverse effects of ε -aminocaproic acid as described in the literature are reviewed.

  20. Childhood epidermolysis bullosa acquisita: Confirmation of diagnosis by skin deficient in Type VII Collagen, enzyme-linked immunosorbent assay, and immunoblotting

    Directory of Open Access Journals (Sweden)

    Nupur Goyal

    2016-01-01

    Full Text Available Epidermolysis bullosa acquisita (EBA is an acquired subepidermal bullous disorder characterized by autoantibodies against Type VII collagen. It usually affects adults; childhood EBA is rare. We describe a 10-year-old girl presenting with recurrent tense blisters predominantly on legs, dorsa of hands and feet accompanied by oral erosions since the age of 5 years. Direct immunofluorescence (IF microscopy showed linear deposition of IgG and C3 along the basement membrane zone (BMZ; indirect IF microscopy on salt-split skin revealed staining of IgG to the dermal side of the split. The patient's serum did not show BMZ staining in recessive dystrophic epidermolysis bullosa skin deficient for Type VII collagen, thus confirming autoantibody reactivity against Type VII collagen. Circulating antibodies against the immunodominant noncollagenous 1 domain of Type VII collagen were detected by ELISA and immunoblotting studies. The patient was treated with oral corticosteroids and dapsone with good improvement.

  1. Childhood Epidermolysis Bullosa Acquisita: Confirmation of Diagnosis by Skin Deficient in Type VII Collagen, Enzyme-linked Immunosorbent Assay, and Immunoblotting.

    Science.gov (United States)

    Goyal, Nupur; Rao, Raghavendra; Balachandran, C; Pai, Sathish; Bhogal, Balbir S; Schmidt, Enno; Zillikens, Detlef

    2016-01-01

    Epidermolysis bullosa acquisita (EBA) is an acquired subepidermal bullous disorder characterized by autoantibodies against Type VII collagen. It usually affects adults; childhood EBA is rare. We describe a 10-year-old girl presenting with recurrent tense blisters predominantly on legs, dorsa of hands and feet accompanied by oral erosions since the age of 5 years. Direct immunofluorescence (IF) microscopy showed linear deposition of IgG and C3 along the basement membrane zone (BMZ); indirect IF microscopy on salt-split skin revealed staining of IgG to the dermal side of the split. The patient's serum did not show BMZ staining in recessive dystrophic epidermolysis bullosa skin deficient for Type VII collagen, thus confirming autoantibody reactivity against Type VII collagen. Circulating antibodies against the immunodominant noncollagenous 1 domain of Type VII collagen were detected by ELISA and immunoblotting studies. The patient was treated with oral corticosteroids and dapsone with good improvement.

  2. A Preliminary Investigation of Caffeinated Alcohol Use During Spring Break.

    Science.gov (United States)

    Linden-Carmichael, Ashley N; Lau-Barraco, Cathy

    2016-06-06

    Caffeinated alcoholic beverages (e.g., Red Bull and vodka) are popular but associated with negative consequences. CABs may be particularly popular during Spring Break, a potentially risky social event. We aimed to identify the prevalence of Spring Break caffeinated alcohol use, determine how caffeinated alcohol use Spring Break drinking habits differ from usual, and examine the association between Spring Break caffeinated alcohol use and alcohol-related problems. Data were collected from 95 college students during March of 2013 and 2014. Students completed questionnaires of their alcohol and caffeinated alcohol use before and during Spring Break and Spring Break alcohol-related problems. Approximately 54% of students used caffeinated alcohol during Spring Break. Spring Break caffeinated alcohol use was associated with more alcohol-related problems, even after controlling for other alcohol consumed and Spring Break vacation status. Caffeinated alcoholic beverages are commonly consumed during Spring Break and their use uniquely predicted harms. Prevention efforts placed on caffeinated alcoholic beverage users may be helpful in reducing Spring Break-related harms.

  3. Characteristics Analysis and Testing of SMA Spring Actuator

    Directory of Open Access Journals (Sweden)

    Jianzuo Ma

    2013-01-01

    Full Text Available The biasing form two-way shape memory alloy (SMA actuator composed of SMA spring and steel spring is analyzed. Based on the force equilibrium equation, the relationship between load capacity of SMA spring and geometric parameters is established. In order to obtain the characteristics of SMA spring actuator, the output force and output displacement of SMA spring under different temperatures are analyzed by the theoretical model and the experimental method. Based on the shape memory effect of SMA, the relationship of the SMA spring actuator's output displacement with the temperature, the stress and strain, the material parameters, and the size parameters is established. The results indicate that the trend of theoretical results is basically consistent with the experimental data. The output displacement of SMA spring actuator is increased with the increasing temperature.

  4. Stiffness and design for strength of trapezoidal Belleville springs

    DEFF Research Database (Denmark)

    Pedersen, Niels Leergaard; Pedersen, Pauli

    2011-01-01

    Belleville springs or coned disc springs are commonly used in machine design. The geometric dimensions of the spring and the determination of non-linear force–displacement curve are regulated by different standards. However, the theory behind Belleville spring design standards is founded on a study...... published in 1936. Furthermore, the common spring design with cross-sections of uniform thickness poses problems in terms of non-uniformity of stress distribution. In view of this, non-linear three-dimensional finite element analyses of spring designs including uniform or variable thickness are carried out...... in this paper. Finite element results are compared with analytical predictions and critically analysed in terms of the effect of Poisson ratio, overall stiffness, and stress distribution in the spring. This is done in order to verify the range of validity of design standards. Finite element analysis emerges...

  5. Management of Pregnancy in a Chilean Patient with Congenital Deficiency of Factor VII and Glanzmann’s Thrombasthenia Variant

    Directory of Open Access Journals (Sweden)

    Nigel P. Murray

    2014-01-01

    Full Text Available Patients with inherited bleeding disorders are rare in obstetric practice but present with prolonged bleeding even after minor invasive procedures. They require a combined approach with obstetric and hematological management of each case, including the neonatal management of a possibly affected fetus. We present the case of a pregnancy in a patient with combined Factor VII deficiency and Glanzmann’s thrombasthenia, the successful obstetric and hematological management of the case, and a review of the literature.

  6. Investigation of inconsistent ENDF/B-VII.1 independent and cumulative fission product yields with proposed revisions

    Energy Technology Data Exchange (ETDEWEB)

    Pigni, Marco T [ORNL; Francis, Matthew W [ORNL; Gauld, Ian C [ORNL

    2015-01-01

    A recent implementation of ENDF/B-VII. independent fission product yields and nuclear decay data identified inconsistencies in the data caused by the use of updated nuclear scheme in the decay sub-library that is not reflected in legacy fission product yield data. Recent changes in the decay data sub-library, particularly the delayed neutron branching fractions, result in calculated fission product concentrations that are incompatible with the cumulative fission yields in the library, and also with experimental measurements. A comprehensive set of independent fission product yields was generated for thermal and fission spectrum neutron induced fission for 235,238U and 239,241Pu in order to provide a preliminary assessment of the updated fission product yield data consistency. These updated independent fission product yields were utilized in the ORIGEN code to evaluate the calculated fission product inventories with experimentally measured inventories, with particular attention given to the noble gases. An important outcome of this work is the development of fission product yield covariance data necessary for fission product uncertainty quantification. The evaluation methodology combines a sequential Bayesian method to guarantee consistency between independent and cumulative yields along with the physical constraints on the independent yields. This work was motivated to improve the performance of the ENDF/B-VII.1 library in the case of stable and long-lived cumulative yields due to the inconsistency of ENDF/B-VII.1 fission p;roduct yield and decay data sub-libraries. The revised fission product yields and the new covariance data are proposed as a revision to the fission yield data currently in ENDF/B-VII.1.

  7. The Next Phase of Title VII Funding for Training Primary Care Physicians for America’s Health Care Needs

    Science.gov (United States)

    Phillips, Robert L.; Turner, Barbara J.

    2012-01-01

    Health care reform will add millions of Americans to the ranks of the insured; however, their access to health care is threatened by a deep decline in the production of primary care physicians. Poorer access to primary care risks poorer health outcomes and higher costs. Meeting this increased demand requires a major investment in primary care training. Title VII, Section 747 of the Public Health Service Act previously supported the growth of the health care workforce but has been severely cut over the past 2 decades. New and expanded Title VII initiatives are required to increase the production of primary care physicians; establish high-functioning academic, community-based training practices; increase the supply of well-trained primary care faculty; foster innovation and rigorous evaluation of these programs; and ultimately to improve the responsiveness of teaching hospitals to community needs. To accomplish these goals, Congress should act on the Council on Graduate Medical Education’s recommendation to increase funding for Title VII, Section 747 roughly 14-fold to $560 million annually. This amount represents a small investment in light of the billions that Medicare currently spends to support graduate medical education, and both should be held to account for meeting physician workforce needs. Expansion of Title VII, Section 747 with the goal of improving access to primary care would be an important part of a needed, broader effort to counter the decline of primary care. Failure to launch such a national primary care workforce revitalization program will put the health and economic viability of our nation at risk. PMID:22412009

  8. The next phase of Title VII funding for training primary care physicians for America's health care needs.

    Science.gov (United States)

    Phillips, Robert L; Turner, Barbara J

    2012-01-01

    Health care reform will add millions of Americans to the ranks of the insured; however, their access to health care is threatened by a deep decline in the production of primary care physicians. Poorer access to primary care risks poorer health outcomes and higher costs. Meeting this increased demand requires a major investment in primary care training. Title VII, Section 747 of the Public Health Service Act previously supported the growth of the health care workforce but has been severely cut over the past 2 decades. New and expanded Title VII initiatives are required to increase the production of primary care physicians; establish high-functioning academic, community-based training practices; increase the supply of well-trained primary care faculty; foster innovation and rigorous evaluation of these programs; and ultimately to improve the responsiveness of teaching hospitals to community needs. To accomplish these goals, Congress should act on the Council on Graduate Medical Education's recommendation to increase funding for Title VII, Section 747 roughly 14-fold to $560 million annually. This amount represents a small investment in light of the billions that Medicare currently spends to support graduate medical education, and both should be held to account for meeting physician workforce needs. Expansion of Title VII, Section 747 with the goal of improving access to primary care would be an important part of a needed, broader effort to counter the decline of primary care. Failure to launch such a national primary care workforce revitalization program will put the health and economic viability of our nation at risk.

  9. Biological and Phylogenetic Characterization of a Genotype VII Newcastle Disease Virus from Venezuela: Efficacy of Field Vaccination

    Science.gov (United States)

    Perozo, Francisco; Marcano, Rosmar

    2012-01-01

    Here we report the biological and molecular characterization of a virulent genotype VII Newcastle disease virus (NDV) circulating in Venezuela and the assessment of the vaccination efficacy under field conditions compared to controlled rearing conditions. Biological pathotyping showed a mean embryo dead time of 50 h and an intracerebral pathogenicity index of 1.86. Sequence-based phylogenetic analysis demonstrated that the virus belongs to genotype VII in class II (a genotype often found in Asia and Africa), representing the first report of the presence of this genotype in the continent of South America. A vaccine-challenge trial in commercial broilers reared in fields or in a experimental setting included dual (live/killed) priming of 1-day-old chicks plus two live NDV and infectious bursal disease virus (IBDV) field vaccinations at days 7 and 17, followed by a very stringent genotype VII NDV challenge at day 28. Serology for NDV and IBDV, bursal integrity, and protection against NDV lethal challenge were assessed. At 28 days, field vaccinates showed significantly lower NDV (1,356 versus 2,384) and higher IBD (7,295 versus 1,489) enzyme-linked immunosorbent assay (ELISA) antibody titers than the experimentally reared birds. A lower bursal size and bursa-body weight ratio (P < 0.05) and higher bursa lesion score were also detected in the field set. Only 57.1% of field vaccinates survived the lethal challenge, differing (P < 0.05) from 90.5% survival in the experimental farm. Overall, results confirmed the presence of the genotype VII viruses in South America and suggest that field-associated factors such as immunosuppression compromise the efficacy of the vaccination protocols implemented. PMID:22238433

  10. Effect of individual dietary fatty acids on postprandial activation of blood coagulation factor VII and fibrinolysis in healthy young men

    DEFF Research Database (Denmark)

    Tholstrup, T.; Miller, G.J.; Bysted, Anette

    2003-01-01

    Background: Hypertriglyceridemia may represent a procoagulant state involving disturbances to the hemostatic system. Plasminogen activator inhibitor type 1 (PAI-1) is increased in the presence of hypertriglyceridemia. Free fatty acids (FFAs) in plasma may promote factor VII (FVII) activation......), a smaller increase in FVII:c (P concentrations (P = 0.028, diet effect), and a tendency to a greater postprandial decline in PAI-1 (P = 0.06, diet effect) compared with the unsaturated test fats (O, T, and L). The increase...

  11. I tre libri di salmi vespertini a otto voci (opp. I, VII e XI) di Giovanni Paolo Colonna

    OpenAIRE

    Vannelli Uva, Michele

    2015-01-01

    Le tre raccolte di salmi da vespro a otto voci nello stile pieno di Giovanni Paolo Colonna (Bologna 1637-1695), pubblicate rispettivamente nel 1681, nel 1686 e nel 1694 (opp.I, VII e XI), costituiscono un oggetto di studio privilegiato nell’ambito della ricca produzione a stampa dell’autore: in primo luogo, esse ebbero ampia e favorevole recezione, come testimoniano la diffusione degli esemplari, le ristampe, le copie manoscritte ricavate dalle edizioni; in secondo luogo, la fortuna postuma d...

  12. Acidification and Increasing CO2 Flux Associated with Five, Springs Coast, Florida Springs (1991-2014)

    Science.gov (United States)

    Barrera, Kira E.; Robbins, Lisa L.

    2017-01-01

    Scientists from the South West Florida Management District (SWFWMD) acquired and analyzed over 20 years of seasonally-sampled hydrochemical data from five first-order-magnitude (springs that discharge 2.83 m3 s-1 or more) coastal springs located in west-central Florida. These data were subsequently obtained by the U.S. Geological Survey (USGS) for further analyses and interpretation. The spring study sites (Chassahowitzka, Homosassa, Kings Bay, Rainbow, and Weeki Wachee), which are fed by the Floridan Aquifer system and discharge into the Gulf of Mexico were investigated to identify temporal and spatial trends of pH, alkalinity, partial pressure of carbon dioxide (pCO2) and CO2 flux.

  13. Nonredundant functions of Arabidopsis LecRK-V.2 and LecRK-VII.1 in controlling stomatal immunity and jasmonate-mediated stomatal closure.

    Science.gov (United States)

    Yekondi, Shweta; Liang, Fu-Chun; Okuma, Eiji; Radziejwoski, Amandine; Mai, Hsien-Wei; Swain, Swadhin; Singh, Prashant; Gauthier, Mathieu; Chien, Hsiao-Chiao; Murata, Yoshiyuki; Zimmerli, Laurent

    2017-12-18

    Stomatal immunity restricts bacterial entry to leaves through the recognition of microbe-associated molecular patterns (MAMPs) by pattern-recognition receptors (PRRs) and downstream abscisic acid and salicylic acid signaling. Through a reverse genetics approach, we characterized the function of the L-type lectin receptor kinase-V.2 (LecRK-V.2) and -VII.1 (LecRK-VII.1). Analyses of interactions with the PRR FLAGELLIN SENSING2 (FLS2) were performed by co-immunoprecipitation and bimolecular fluorescence complementation and whole-cell patch-clamp analyses were used to evaluate guard cell Ca2+ -permeable cation channels. The Arabidopsis thaliana LecRK-V.2 and LecRK-VII.1 and notably their kinase activities were required for full activation of stomatal immunity. Knockout lecrk-V.2 and lecrk-VII.1 mutants were hyper-susceptible to Pseudomonas syringae infection and showed defective stomatal closure in response to bacteria or to the MAMPs flagellin and EF-Tu. By contrast, Arabidopsis over-expressing LecRK-V.2 or LecRK-VII.1 demonstrated a potentiated stomatal immunity. LecRK-V.2 and LecRK-VII.1 are shown to be part of the FLS2 PRR complex. In addition, LecRK-V.2 and LecRK-VII.1 were critical for methyl jasmonate (MeJA)-mediated stomatal closure, notably for MeJA-induced activation of guard cell Ca2+ -permeable cation channels. This study highlights the role of LecRK-V.2 and LecRK-VII.1 in stomatal immunity at the FLS2 PRR complex and in MeJA-mediated stomatal closure. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

  14. Implementasi Model Pembelajaran Problem Based Learning (Pbl) Dengan Media Mind Mapping Terhadap Kemampuan Pemecahan Masalah Siswa Kelas VII SMP N 2 Mengwi Badung

    OpenAIRE

    Apriliana, Dewa Ayu Nyoman; Diarta, I Made

    2016-01-01

    Penelitian ini bertujuan untuk mengimplementasikan model pembelajaran problem based learning (PBL) sehingga dapat berpengaruh terhadap nilai media mind mapping dan kemampuan masalah siswa kelas VII SMP N 2 Mengwi Metode penelitian ini menggunakan Quasi Experimental Design (Sugiyono, 2011) dengan rancangan Nonequivalent Control Group Design. Populasi yang digunakan pada penelitian ini adalah seluruh siswa kelas VII semester II tahun pelajaran 2014/2015 di SMP N 2 Mengwi yang berjumlah Sembilan...

  15. Rescue of coagulation factor VII function by the U1+5A snRNA.

    Science.gov (United States)

    Pinotti, Mirko; Balestra, Dario; Rizzotto, Lara; Maestri, Iva; Pagani, Franco; Bernardi, Francesco

    2009-06-18

    Our previous studies with genomic minigenes have demonstrated that an engineered small nuclear RNA-U1 (U1+5a) partially rescued coagulation factor VII (FVII) mRNA processing impaired by the 9726+5G>A mutation. Here, to evaluate the U1+5a effects on FVII function, we devised a full-length FVII splicing-competent construct (pSCFVII-wt). This construct drove in COS-1 cells the synthesis of properly processed FVII transcripts and of secreted functional FVII (23 +/- 4 ng/mL), which were virtually undetectable upon introduction of the 9726+5G>A mutation (pSCFVII-9726+5a). Cotransfection of pSCFVII-9726+5a with pU1+5a resulted in a partial rescue of FVII splicing and protein biosynthesis. The level increase in medium was dose dependent and, with a molar excess (1.5x) of pU1+5a, reached 9.5% plus or minus 3.2% (5.0 +/- 2.8 ng/mL) of FVII-wt coagulant activity. These data provide the first insights into the U1-snRNA-mediated rescue of donor splice sites at protein level, thus further highlighting its therapeutic implications in bleeding disorders, which would benefit even from tiny increase of functional levels.

  16. PERMAINAN TRADISIONAL “GAPREK KEMPUNG” SEBAGAI MEDIA PEMBELAJARAN PADA MATA PELAJARAN EKONOMI KELAS VII

    Directory of Open Access Journals (Sweden)

    Fera Wulandari

    2017-03-01

    Full Text Available The purpose of this study is (1 to produce a media product of social science learning traditional game Gaprek Kempung by utilizing the existing facilities in the surrounding environment, (2 to determine the effectiveness of the development of instructional media of social science traditional games Gaprek Kempung to improve learning outcomes on economic subjects grade VII SMP N 1 Tumpang. Based on the analysis testing the effectiveness of instructional media traditional game Gaprek Kempung by using software IBM SPSS 24 with the formula t-test, t-hitung obtained from posttest control class and experimental class SMP N 1 Tumpang amounted to 2,763 with t-table value is 2.005 thus t-hitung> t-tabel which means an increase in the economic value of learning outcomes experimental class is better than the control class. Furthermore, gained a significance value of 0.007 t-tabel yang berarti peningkatan nilai hasil belajar ekonomi kelas eksperimen lebih baik daripada kelas kontrol. Selanjutnya, didapatkan nilai signifikansi sebesar 0,007<α (0,05 yang menunjukkan bahwa H1 diterima artinya kelas eksperimen lebih baik dari pada kelas kontrol. Penelitian ini menunjukkan bahwa media pembelajaran permainan tradisional Gaprek Kempung lebih meningkatkan nilai hasil belajar ekonomi siswa dibandingkan tanpa menggunakan media pembelajaran. Hal ini berarti media pembelajaran permainan tradisional Gaprek Kempung layak digunakan untuk meningkatkan hasil belajar siswa dan media pembelajaran permainan tradisional Gaprek Kempung efektif untuk meningkatkan hasil belajar siswa.

  17. Traces of factor VIIa modulate thromboplastin sensitivity to factors V, VII, X, and prothrombin.

    Science.gov (United States)

    Smith, S A; Comp, P C; Morrissey, J H

    2006-07-01

    Thromboplastin reagents are used to conduct prothrombin time (PT) clotting tests to monitor oral anticoagulant therapy and screen for clotting factor deficiencies. Thromboplastins made from purified, recombinant tissue factor are generally more sensitive to changes in plasma factor (F) VII levels than are thromboplastins prepared from tissue extracts. This may be problematic as FVII's short plasma half-life can result in day-to-day fluctuation during oral anticoagulant therapy. We hypothesized that trace contamination of tissue-derived thromboplastins with FVII(a) blunts sensitivity to plasma FVII levels. Traces of purified FVIIa were added to thromboplastin reagents prepared using recombinant human tissue factor and the effect on sensitivity to individual clotting factors was quantified in PT clotting assays. Adding 5-100 pm FVIIa not only decreased thromboplastin sensitivity to plasma FVII, it surprisingly increased sensitivity to plasma levels of FV, FX and prothrombin. In addition, traces of FVIIa interacted with changes in the salt content and phospholipid composition of recombinant thromboplastins to further modulate their sensitivities to individual clotting factors. These results help explain how thromboplastin reagents of differing composition exhibit differing sensitivities to individual clotting factor levels. Implications of our results for monitoring oral anticoagulant therapy and other uses of the PT assay are discussed.

  18. Japanese collaborative study to assess inter-laboratory variation in factor VII activity assays.

    Science.gov (United States)

    Takamiya, O; Ishikawa, S; Ohnuma, O; Suehisa, H; Iijima, K; Kayamori, Y; Bando, S; Higashi, K

    2007-08-01

    The clinical phenotype manifest by patients with factor VII (FVII) deficiency correlates poorly with that predicted by laboratory tests. Despite its importance, there are no data on the variability of inter-laboratory determinations of low to very low plasma FVII activity (FVII:C). We distributed three FVII-deficient plasma samples, prepared by immunoaffinity chromatography, to 58 laboratories in Japan. All samples were assayed using standardized reference plasma as a calibrator. Recombinant thromboplastin was also supplied as a common reagent. In the case of sample A, which had a very low FVII:C, the use of standardized reference plasma and thromboplastin, lowered the variability of inter-laboratory measurements, when compared with the variability observed when samples were assayed using the respective laboratory's routine method. The data obtained indicated that results for samples with a very low FVII:C were greatly influenced by the number of plasma dilutions used in constructing a standard activity curve, and also by the type of calibrator and thromboplastin. Such variability was not seen for samples with moderate FVII:C. We conclude that it is necessary to develop a more sensitive and accurate FVII:C measurement system for the diagnosis and treatment of FVII deficiency.

  19. Non-fasting factor VII coagulant activity (FVII:C) increased by high-fat diet

    DEFF Research Database (Denmark)

    Bladbjerg, Else-Marie; Marckmann, P; Sandström, B

    1994-01-01

    :Bt/FVII:Am (a measure of FVII activation) increased from fasting levels on both diets, but most markedly on the high-fat diet. In contrast, FVII:Am (a measure of FVII protein) tended to decrease from fasting levels on both diets. FVII:C rose from fasting levels on the high-fat diet, but not on the low-fat diet......Preliminary observations have suggested that non-fasting factor VII coagulant activity (FVII:C) may be related to the dietary fat content. To confirm this, we performed a randomised cross-over study. Seventeen young volunteers were served 2 controlled isoenergetic diets differing in fat content (20......% or 50% of energy). The 2 diets were served on 2 consecutive days. Blood samples were collected at 8.00 h, 16.30 h and 19.30 h, and analysed for triglycerides, FVII coagulant activity using human (FVII:C) or bovine thromboplastin (FVII:Bt), and FVII amidolytic activity (FVII:Am). The ratio FVII...

  20. PENGEMBANGAN SOAL MATEMATIKA MODEL TIMSS UNTUK MENDUKUNG PEMBELAJARAN MATEMATIKA SMP KELAS VII KURIKULUM 2013

    Directory of Open Access Journals (Sweden)

    M. Andy Rudhito

    2016-02-01

    DEVELOPING THE TIMSS MATH PROBLEM MODEL TO SUPPORT THE MATHEMATICS LEARNING IN GRADE VII USING THE 2013 CURRICULUM Abstract: This study was aimed to produce a valid and practical TIMMS math problem model for junior high school students using the 2013 curriculum. The study used the research and development design. The design process of the problems as assessment instruments was carried out through prototyping involving two stages. Prototype I was the design product and the problem development done by the researchers themselves, while Prototype II was the revision of Prototype I based on the feedback provided by experts, colleagues, and Mathematics teachers in the form of validators’ notes and the minutes taken from discussions. The findings showed that the book of math problems was written by grouping the chapters following the materials domains as those in TIMSS, that is, numbers, geometry, algebra, data, and probability. For the student book, it was not nsecessary to write the materials domain, the essential topics, and the cognitive domain. The feedback from the FGD was that the problems should be arranged from the easiest ones to the most difficult ones. The multiple choice items should not be written in the form of questions, but in the form of incomplete sentences with the blanks in the middle or the end of the sentences. The items should not ask about implication. Keywords: Development of problems, junior high school mathematics, TIMSS, Curriculum 2013

  1. Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain.

    Science.gov (United States)

    Snyder, E Y; Taylor, R M; Wolfe, J H

    1995-03-23

    Many metabolic diseases affecting the central nervous system are refractory to treatment because the blood-brain barrier restricts entry of therapeutic molecules. It may be possible to deliver therapeutic gene products directly to the brain by transplantation of neural progenitor cells, which can integrate into the murine central nervous system in a cytoarchitecturally appropriate manner. We tested this approach in mucopolysaccharidosis VII (Sly disease), a lysosomal storage disorder of humans, dogs and mice caused by an inherited deficiency of beta-glucuronidase. Lysosomal accumulation of glycosaminoglycans occurs in the brain and other tissues, causing a fatal progressive degenerative disorder, including mental retardation. Treatments are designed to provide a source of normal enzyme for uptake by diseased cells. We report here that by transplanting beta-glucuronidase-expressing neural progenitors into the cerebral ventricles of newborn mice, donor cells engrafted throughout the neuraxis. At maturity, donor-derived cells were present as normal constituents of diverse brain regions. beta-Glucuronidase activity was expressed along the entire neuraxis, resulting in widespread correction of lysosomal storage in neurons and glia in affected mice.

  2. MT71x: Multi-Temperature Library Based on ENDF/B-VII.1

    Energy Technology Data Exchange (ETDEWEB)

    Conlin, Jeremy Lloyd [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Parsons, Donald Kent [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Gray, Mark Girard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Lee, Mary Beth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); White, Morgan Curtis [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-12-16

    The Nuclear Data Team has released a multitemperature transport library, MT71x, based upon ENDF/B-VII.1 with a few modifications as well as additional evaluations for a total of 427 isotope tables. The library was processed using NJOY2012.39 into 23 temperatures. MT71x consists of two sub-libraries; MT71xMG for multigroup energy representation data and MT71xCE for continuous energy representation data. These sub-libraries are suitable for deterministic transport and Monte Carlo transport applications, respectively. The SZAs used are the same for the two sub-libraries; that is, the same SZA can be used for both libraries. This makes comparisons between the two libraries and between deterministic and Monte Carlo codes straightforward. Both the multigroup energy and continuous energy libraries were verified and validated with our checking codes checkmg and checkace (multigroup and continuous energy, respectively) Then an expanded suite of tests was used for additional verification and, finally, verified using an extensive suite of critical benchmark models. We feel that this library is suitable for all calculations and is particularly useful for calculations sensitive to temperature effects.

  3. Temperature and ionization balance dependence of O VII line ratios. [in solar corona

    Science.gov (United States)

    Acton, L. W.; Brown, W. A.

    1978-01-01

    The forbidden-plus-intersystem to resonance line ratio (G) for the heliumlike ion O VII is calculated, taking into account cascades, blended satellite lines, and radiative plus dielectric recombination. It is noted that G is of particular use for investigating radiative-transfer effects and nonequilibrium ionization in the solar corona and that the calculations are applicable to a low-density optically thin Maxwellian plasma. The temperature dependence of G is considered for the case of a steady-state equilibrium plasma, and the effect of departures from ionization equilibrium on G is examined. It is found that G is quite insensitive to temperature over the range from 600,000 to 6 million K for a steady-state plasma, but that recombinations may be suppressed or dominant, depending on the relative abundance of O VIII, for a plasma in which the state of ionization is not in equilibrium with the electron temperature. This latter effect is shown to be capable of causing large variations in G that are dependent on electron temperature.

  4. A high fat meal activates blood coagulation factor VII in rats

    DEFF Research Database (Denmark)

    Olsen, Aage K; Bladbjerg, Else M; Hansen, Axel K

    2002-01-01

    In humans, high fat meals cause postprandial activation of blood coagulation factor VII (FVII), but human studies have not provided definite evidence for a prothrombotic effect of dietary FVII activation. An animal model would be an attractive way to pursue this question and therefore we tested...... the LEW/Mol rat. We gavaged 3 mL of a fat emulsion (n = 42) or 3 mL isotonic glucose (n = 42). Blood was sampled by heart puncture 2, 4 and 6 h (n = 14/group at each time) after the fat/glucose load. Furthermore, blood was sampled from 16 untreated rats to determine the baseline levels. Triglyceride....../L), and FVIIa was significantly raised at 4 h (54 U/L) and 6 h (58 U/L) compared with baseline (29 U/L). No postprandial changes in FVIIc, FVIIam and TAT were observed. Glucose administration did not affect any variable. We conclude that the LEW/Mol rat is a promising model for use in future studies...

  5. Adipose-derived stem cells express higher levels of type VII collagen under specific culture conditions.

    Science.gov (United States)

    Maeda, Yuichiro; Hasegawa, Toshio; Wada, Akino; Fukai, Tatsuo; Iida, Hideo; Sakamoto, Atsushi; Ikeda, Shigaku

    2017-12-01

    Type VII collagen (Col7) is a major component of the anchoring fibrils at the dermoepidermal junction. Adipose-derived stem cells (ADSCs) are a cell population highly useful in regenerative medicine because of their ease of isolation and their potential for multilineage differentiation. Based on the observations that K14 was expressed in undifferentiated ADSCs and the expression was downregulated after differentiation into adipocytes, we speculated that ADSCs are keratinocyte stem/progenitor cells. ADSCs were co-cultured with fibroblasts on type IV collagen in a medium containing all-trans retinoic acid and bone morphogenetic protein 4. At day 14 of culture in keratinocyte serum-free medium, the cells were harvested and subjected to immunofluorescence, flow cytometry, real-time PCR, and western blotting. Approximately, 45% of ADSCs were immunostained positively for anti-human cytokeratin 10, and approximately 80% were stained positively for Col7. Flow cytometry, real-time PCR, and western blotting also confirmed that differentiated ADSCs expressed higher levels of Col7. These findings support the therapeutic potential of ADSCs, not only for wound healing, but also for the correction of Col7 deficiencies.

  6. 'Struensee's memoir on the situation of the King' (1772): Christian VII of Denmark.

    Science.gov (United States)

    Schioldann, Johan

    2013-06-01

    Christian VII of Denmark (1749-1808) was insane throughout his long reign. The royal physician, Johann Friedrich Struensée (1737-72), usurped his power. In 1771 the King appointed him Privy Cabinet Minister. Struensée revolutionized the whole administration of the Danish-Norwegian kingdom and had an adulterous relationship with the Queen, Caroline Mathilda, George III's sister. In January 1772 he was arrested, sentenced to death for lese-majesty and executed. During his confinement, he wrote a memoir on the King's condition, which he considered to be caused by, or the effect of, masturbation. In 1906 Christiansen interpreted it as a case of dementia praecox, i.e. schizophrenia. It is now suggested that Christian's insanity, like that of George III (his cousin), might have been due to porphyria - the 'royal malady', possibly inherited through his mother, Princess Louise of England or his father, King Frederik V, who died from an illness which retrospectively resembles a case of porphyria.

  7. KEEFEKTIFAN MODEL PEMBELAJARAN AIR DENGAN PENDEKATAN RME TERHADAP KEMAMPUAN KOMUNIKASI MATEMATIK MATERI GEOMETRI KELAS VII

    Directory of Open Access Journals (Sweden)

    Nana Umi Latifah

    2015-03-01

    Full Text Available Tujuan penelitian ini adalah untuk mengetahui apakah pembelajaran model AIR dengan pendekatan RME efektif terhadap kemampuan komunikasi matematik peserta didik daripada pembelajaran ekspositori, serta untuk mengetahui apakah pembelajaran model AIR dengan pendekatan RME efektif terhadap kemampuan komunikasi matematik terkait dengan tingkat kemampuan awal rendah, sedang maupun tinggi. Populasi dalam penelitian ini adalah seluruh peserta didik kelas VII SMP Negeri 5 Blora tahun pelajaran 2013/2014. Pengambilan sampel menggunakan teknik Simple Random Sampling dan terpilih 37 peserta didik sebagai kelas eksperimen, dan 37 peserta didik sebagai kelas kontrol. Data diperoleh melalui metode dokumentasi, tes, dan observasi. Analisis data kemampuan komunikasi matematik meliputi uji normalitas dengan uji Kolmogorov-Smirnov, uji homogenitas dengan uji Levene, dan uji kesamaan dua rata-rata menggunakan pihak kanan dengan Independent Samples T-test. Simpulan yang diperoleh adalah penerapan model pembelajaran AIR dengan pendekatan RME efektif terhadap kemampuan komunikasi matematik peserta didik daripada pembelajaran ekspositori, serta penerapan model pembelajaran AIR dengan pendekatan RME efektif terhadap kemampuan komunikasi matematik pada peserta didik berkemampuan awal tinggi daripada pembelajaran ekspositori namun kurang efektif penerapannya pada peserta didik berkemampuan awal rendah dan sedang.

  8. A Stellar Population Gradient in VII ZW 403: Implications for the Formation of Blue Compact Dwarf Galaxies

    Science.gov (United States)

    Schulte-Ladbeck, Regina E.; Hopp, Ulrich; Crone, Mary M.; Greggio, Laura

    1999-11-01

    We present evidence for the existence of an old stellar halo in the blue compact dwarf galaxy VII Zw 403. VII Zw 403 is the first blue compact dwarf galaxy for which a clear spatial segregation of the resolved stellar content into a core-halo structure is detected. Multicolor Hubble Space Telescope WFPC2 (HST/WFPC2) observations indicate that active star formation occurs in the central region, but is strikingly absent at large radii. Instead, a globular-cluster-like red giant branch suggests the presence of an old (>10 Gyr) and metal-poor (=-1.92) stellar population in the halo. While the vast majority of blue compact dwarf galaxies have been recognized to possess halos of red color in ground-based surface photometry, our observations of VII Zw 403 establish for the first time a direct correspondence between a red halo color and the presence of old, red giant stars. If the halos of blue compact dwarf galaxies are all home to such ancient stellar populations, then the fossil record conflicts with delayed-formation scenarios for dwarfs. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained and supported in part through grant AR-06404.01-95A from the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555.

  9. Microbial Biosignatures in High Iron Thermal Springs

    Science.gov (United States)

    Parenteau, M. N.; Embaye, T.; Jahnke, L. L.; Cady, S. L.

    2003-12-01

    The emerging anoxic source waters at Chocolate Pots hot springs in Yellowstone National Park contain 2.6 to 11.2 mg/L Fe(II) and are 51-54° C and pH 5.5-6.0. These waters flow down the accumulating iron deposits and over three major phototrophic mat communities: Synechococcus/Chloroflexus at 51-54° C, Pseudanabaena at 51-54° C, and a narrow Oscillatoria at 36-45° C. We are assessing the contribution of the phototrophs to biosignature formation in this high iron system. These biosignatures can be used to assess the biological contribution to ancient iron deposits on Earth (e.g. Precambrian Banded Iron Formations) and, potentially, to those found on Mars. Most studies to date have focused on chemotrophic iron-oxidizing communities; however, recent research has demonstrated that phototrophs have a significant physiological impact on these iron thermal springs (Pierson et al. 1999, Pierson and Parenteau 2000, and Trouwborst et al., 2003). We completed a survey of the microfossils, biominerals, biofabrics, and lipid biomarkers in the phototrophic mats and stromatolitic iron deposits using scanning and transmission electron microscopy (SEM and TEM), energy dispersive spectrometry (EDS), powder X-ray diffraction (XRD), and gas chromatography-mass spectroscopy (GC-MS). The Synechococcus/Chloroflexus mat was heavily encrusted with iron silicates while the narrow Oscillatoria mat was encrusted primarily with iron oxides. Encrustation of the cells increased with depth in the mats. Amorphous 2-line ferrihydrite is the primary precipitate in the spring and the only iron oxide mineral associated with the mats. Goethite, hematite, and siderite were detected in dry sediment samples on the face of the main iron deposit. Analysis of polar lipid fatty acid methyl esters (FAME) generated a suite of lipid biomarkers. The Synechococcus/Chloroflexus mat contained two mono-unsaturated isomers of n-C18:1 with smaller amounts of polyunsaturated n-C18:2, characteristic of cyanobacteria

  10. Scoping assessment of radiological doses to aquatic organisms and wildlife -- N Springs. [N Springs

    Energy Technology Data Exchange (ETDEWEB)

    Poston, T.M.; Soldat, J.K.

    1992-10-01

    Estimated does rates were determined for endemic biota inhabiting the N Springs area based primarily on spring water data collected from the first 6 months of 1991. Radiological dose estimates were computed from measured values of specific radionuclides and modeled levels of radionuclides using established computer codes. The highest doses were predicted in hypothetical populations of clams, fish-eating ducks, and rabbits. The calculated dose estimates did not exceed 1 rad/d, an administrative dose rate established by the US Department of Energy for the protection of native aquatic biota. An administrative dose rate has not been established for terrestrial wildlife.

  11. Phototrophy in Mildly Acidic Hot Spring Ecosystems

    Science.gov (United States)

    Fecteau, K.; Boyd, E. S.; Shock, E.

    2014-12-01

    Microbial light-driven reduction of carbon in continental hydrothermal ecosystems is restricted to environments at temperatures less than 73 °C. In circumneutral and alkaline systems bacterial phototrophs (cyanobacteria and anoxygenic phototrophs) are suggested to be principally responsible for this activity whereas algal (i.e., eukaryotic) phototrophs are thought to be responsible for this activity in acidic systems. In Yellowstone National Park numerous examples of phototrophic microbial communities exist at high and low pH, while hot springs with intermediate pH (values 3-5) are rare and commonly dilute. It is thought that the transition from algal photosynthesis to bacterial photosynthesis occurs within this pH range. To test this hypothesis, we sequenced bacterial and eukaryal small subunit ribosomal RNA genes, analyzed pigments, and performed comprehensive geochemical measurements from 12 hot springs within this pH realm. At all sites, the largest phototrophic population was either comprised of Cyanobacteria or affiliated with the algal order Cyanidiales, which are ubiquitous in acidic springs, yet abundant sequences of both lineages were present in 8 of the 12 sites. Nevertheless, some of these samples exceeded the known temperature limit of the algae (56 °C), suggesting that these populations are dead or inactive. Indeed, one site yielded evidence for a large Cyanidiales population as the only phototrophs present, yet an experiment at the time of sampling failed to demonstrate light-driven carbon fixation, and analysis of extracted pigments showed a large amount of the chlorophyll degradation product pheophorbide a and very little intact chlorophyll, indicating photosynthesis occurred at this site when conditions were different. Our observations illustrate the dynamic nature of these systems that may be transiently conducive to photosynthesis, which may open niches for phototrophs of both domains and likely played a role in the evolution of photosynthesis.

  12. Experimental evidence for competitive growth advantage of genotype VII over VI: implications for foot-and-mouth disease virus serotype A genotype turnover in nature.

    Science.gov (United States)

    Mohapatra, J K; Subramaniam, S; Singh, N K; Sanyal, A; Pattnaik, B

    2012-04-01

    In India, systematic genotype replacement has been observed for serotype A foot-and-mouth disease virus. After a decade of co-circulation of genotypes VI and VII, genotype VII emerged as the single dominant genotype since 2001. To derive possible explanations for such epochal evolution dynamics, in vitro intergenotype growth competition experiments involving both co- and superinfection regimes were conducted. Coinfection of BHK-21 cells demonstrated abrupt loss in the genotype VI viral load with commensurate increase in the load of genotype VII as measured by the genotype differentiating ELISA, RT-PCR and real-time RT-PCR. The superinfection dynamics was shaped by temporal spacing of infection, where the invading genotype VII took more number of passages than coinfection to eventually overtake the resident genotype VI. It was speculated that such superior replicative fitness of genotype VII could have been a possible factor for the ultimate dominance of genotype VII in nature. Copyright © 2011 Elsevier Ltd. All rights reserved.

  13. Penetrating ocular trauma from trampoline spring.

    Science.gov (United States)

    Spokes, David; Siddiqui, Salina; Vize, Colin

    2010-02-01

    The case is presented of a 12-year old boy who sustained severe penetrating ocular trauma while playing on a domestic trampoline. A main spring broke under tension and the hook had struck the eye at high velocity and penetrated the sclera. Primary repair was undertaken but on review it became apparent the eye could not be salvaged. Evisceration was carried out and an orbital implant was placed. Post-operative cosmesis is acceptable. This type of injury has not been reported before. Adult supervision of children on trampolines is recommended to minimise the chance of serious injury.

  14. The United States and the Arab Spring

    Directory of Open Access Journals (Sweden)

    Timo Kivimäki

    2013-01-01

    Full Text Available This article reveals, by studying correlative relationships between US regime support and regime properties, that the US foreign policy in the Middle East has traditionally helped governments to limit the political participation of Islamists, communists, enemies of Israel and populations that could be hostile to the US oil interests. This way the US economic and strategic security interests have contributed to human insecurity in the region. With the exception of the last interest, the US has relaxed its support for repression of the above-mentioned groups. This seems to be one of the international factors that made the Arab Spring possible.

  15. Novosadski golozrni, a spring oat variety

    Directory of Open Access Journals (Sweden)

    Pržulj Novo

    2001-01-01

    Full Text Available The naked oat variety Novosadski golozrni was developed from a cross between the variety Adam and a spring-type naked oat line from Canada. The variety is early, medium tall, with excellent resistance to lodging. The yield of Novosadski golozrni is 30-40% lower than that of the hulled standard and it is to the largest measure dependent on the interaction variety x year x location. The variety has high contents of proteins and fats (19.2% DM and 6.2% DM, respectively and a low cellulose content (2.8% DM. .

  16. Getting started with Spring Framework a hands-on guide to begin developing applications using Spring Framework

    CERN Document Server

    Sharma, J

    2016-01-01

    Getting started with Spring Framework is a hands-on guide to begin developing applications using Spring Framework. The examples (consisting of 74 sample projects) that accompany this book are based on Spring 4.3 and Java 8. You can download the examples described in this book from the following GitHub project:github.com/getting-started-with-spring/3rdEdition This book is meant for Java developers with little or no knowledge of Spring Framework. Getting started with Spring Framework, Third Edition has been updated to reflect changes in Spring 4.3 and also includes new chapters on Java-based configuration and Spring Data (covers Spring Data JPA and Spring Data MongoDB projects). The existing chapters have been revised to include information on Java-based configuration. The book also includes some new information on bean definition profiles, importing application context XML files, lazy autowiring, creating custom qualifier annotations, JSR 349 annotations, spring-messaging module, Java 8's Optional type, and s...

  17. The Egyptian Arab Spring and Political Islam

    Directory of Open Access Journals (Sweden)

    Ayman Gad El ashkar

    2016-07-01

    Full Text Available This study elaborates and analyzes the phenomenon and concept of political Islam, the reasons of the increased role of the Islamists and their political and reformist tendencies in the light of the Egyptian revolution of Arab Spring, reasons and the main factors that have contributed on their advent into power and their influence in that time, the issue of the application of Islamic Sharia and complex realities about this dilemma. The revolutions of Arab Spring, including the Egyptian revolution, are considered one of the most important and most dangerous events in the XXI century after the terrorist attacks of 11 September 2001, not only in the Middle East but throughout the world because of their impact on peace and global security. The growth of the phenomenon of political Islam and the advent of Islamists into power in Egypt has represented one of the most remarkable features of this sudden revolution. No doubt that the issue of the relationship between Islam and the state's political system raises many confusing questions for many people. In this sense the importance of this study will directly identify the fact that the leadership of Islamists in Egypt is not the implementation of Islamic Sharia but their movements and ideology.

  18. Hydrosalinity studies of the Virgin River, Dixie Hot Springs, and Littlefield Springs, Utah, Arizona, and Nevada

    Science.gov (United States)

    Gerner, Steven J.; Thiros, Susan A.; Gerner, Steven J.; Thiros, Susan A.

    2014-01-01

    The Virgin River contributes a substantial amount of dissolved solids (salt) to the Colorado River at Lake Mead in the lower Colorado River Basin. Degradation of Colorado River water by the addition of dissolved solids from the Virgin River affects the suitability of the water for municipal, industrial, and agricultural use within the basin. Dixie Hot Springs in Utah are a major localized source of dissolved solids discharging to the Virgin River. The average measured discharge from Dixie Hot Springs during 2009–10 was 11.0 cubic feet per second (ft3/s), and the average dissolved-solids concentration was 9,220 milligrams per liter (mg/L). The average dissolved-solids load—a measurement that describes the mass of salt that is transported per unit of time—from Dixie Hot Springs during this period was 96,200 tons per year (ton/yr). Annual dissolved-solids loads were estimated at 13 monitoring sites in the Virgin River Basin from streamflow data and discrete measurements of dissolved-solids concentrations and (or) specific conductance. Eight of the sites had the data needed to estimate annual dissolved-solids loads for water years (WYs) 1999 through 2010. During 1999–2010, the smallest dissolved-solids loads in the Virgin River were upstream of Dixie Hot Springs (59,900 ton/yr, on average) and the largest loads were downstream of Littlefield Springs (298,200 ton/yr, on average). Annual dissolved-solids loads were smallest during 2002–03, which was a period of below normal precipitation. Annual dissolved-solids loads were largest during 2005—a year that included a winter rain storm that resulted in flooding throughout much of the Virgin River Basin. An average seepage loss of 26.7 ft3/s was calculated from analysis of monthly average streamflow from July 1998 to September 2010 in the Virgin River for the reach that extends from just upstream of the Utah/Arizona State line to just above the Virgin River Gorge Narrows. Seepage losses from three river reaches

  19. PENGEMBANGAN INSTRUMEN ASESMEN MENULIS KREATIF CERITA FANTASI UNTUK SISWA KELAS VII SMP

    Directory of Open Access Journals (Sweden)

    Anggie Lestantiya Febriyanti

    2017-10-01

    hasil uji validasi pada ahli asesmen, ahli pembelajaran sastra, dan uji coba produk pada siswa kelas VII SMP.

  20. Mycobacterium tuberculosis type VII secreted effector EsxH targets host ESCRT to impair trafficking.

    Directory of Open Access Journals (Sweden)

    Alka Mehra

    2013-10-01

    Full Text Available Mycobacterium tuberculosis (Mtb disrupts anti-microbial pathways of macrophages, cells that normally kill bacteria. Over 40 years ago, D'Arcy Hart showed that Mtb avoids delivery to lysosomes, but the molecular mechanisms that allow Mtb to elude lysosomal degradation are poorly understood. Specialized secretion systems are often used by bacterial pathogens to translocate effectors that target the host, and Mtb encodes type VII secretion systems (TSSSs that enable mycobacteria to secrete proteins across their complex cell envelope; however, their cellular targets are unknown. Here, we describe a systematic strategy to identify bacterial virulence factors by looking for interactions between the Mtb secretome and host proteins using a high throughput, high stringency, yeast two-hybrid (Y2H platform. Using this approach we identified an interaction between EsxH, which is secreted by the Esx-3 TSSS, and human hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs/Hrs, a component of the endosomal sorting complex required for transport (ESCRT. ESCRT has a well-described role in directing proteins destined for lysosomal degradation into intraluminal vesicles (ILVs of multivesicular bodies (MVBs, ensuring degradation of the sorted cargo upon MVB-lysosome fusion. Here, we show that ESCRT is required to deliver Mtb to the lysosome and to restrict intracellular bacterial growth. Further, EsxH, in complex with EsxG, disrupts ESCRT function and impairs phagosome maturation. Thus, we demonstrate a role for a TSSS and the host ESCRT machinery in one of the central features of tuberculosis pathogenesis.

  1. Type VII collagen deficiency causes defective tooth enamel formation due to poor differentiation of ameloblasts.

    Science.gov (United States)

    Umemoto, Hiroko; Akiyama, Masashi; Domon, Takanori; Nomura, Toshifumi; Shinkuma, Satoru; Ito, Kei; Asaka, Takuya; Sawamura, Daisuke; Uitto, Jouni; Uo, Motohiro; Kitagawa, Yoshimasa; Shimizu, Hiroshi

    2012-11-01

    Recessive dystrophic epidermolysis bullosa (RDEB) is caused by mutations in the gene encoding type VII collagen (COL7), a major component of anchoring fibrils in the epidermal basement membrane zone. Patients with RDEB present a low oral hygiene index and prevalent tooth abnormalities with caries. We examined the tooth enamel structure of an RDEB patient by scanning electron microscopy. It showed irregular enamel prisms, indicating structural enamel defects. To elucidate the pathomechanisms of enamel defects due to COL7 deficiency, we investigated tooth formation in Col7a1(-/-) and COL7-rescued humanized mice that we have established. The enamel from Col7a1(-/-) mice had normal surface structure. The enamel calcification and chemical composition of Col7a1(-/-) mice were similar to those of the wild type. However, transverse sections of teeth from the Col7a1(-/-) mice showed irregular enamel prisms, which were also observed in the RDEB patient. Furthermore, the Col7a1(-/-) mice teeth had poorly differentiated ameloblasts, lacking normal enamel protein-secreting Tomes' processes, and showed reduced mRNA expression of amelogenin and other enamel-related molecules. These enamel abnormalities were corrected in the COL7-rescued humanized mice expressing a human COL7A1 transgene. These findings suggest that COL7 regulates ameloblast differentiation and is essential for the formation of Tomes' processes. Collectively, COL7 deficiency is thought to disrupt epithelial-mesenchymal interactions, leading to defective ameloblast differentiation and enamel malformation in RDEB patients. Copyright © 2012 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  2. Mutagenesis in sequence encoding of human factor VII for gene therapy of hemophilia

    Directory of Open Access Journals (Sweden)

    B Kazemi

    2009-12-01

    Full Text Available "nBackground: Current treatment of hemophilia which is one of the most common bleeding disorders, involves replacement therapy using concentrates of FVIII and FIX .However, these concentrates have been associated with viral infections and thromboembolic complications and development of antibodies. "nThe use of recombinant human factor VII (rhFVII is effective  for the treatment of patients with  hemophilia A or B, who develop antibodies ( referred as inhibitors against  replacement therapy , because it induces coagulation independent of FVIII and FIX. However, its short half-life and high cost have limited its use. One potential solution to this problem may be the use of FVIIa gene transfer, which would attain continuing therapeutic levels of expression from a single injection. The aim of this study was to engineer a novel hFVII (human FVII gene containing a cleavage site for the intracellular protease and furin, by PCR mutagenesis "nMethods: The sequence encoding light and heavy chains of hFVII, were amplified by using hFVII/pTZ57R and specific primers, separately. The PCR products were cloned in pTZ57R vector. "nResults and discussion: Cloning was confirmed by restriction analysis or PCR amplification using specific primers and plasmid universal primers. Mutagenesis of sequence encoding light and heavy chain was confirmed by restriction enzyme. "nConclusion: In the present study, it was provided recombinant plasmids based on mutant form of DNA encoding light and heavy chains.  Joining mutant form of DNA encoding light chain with mutant heavy chain led to a new variant of hFVII. This variant can be activated by furin and an increase in the proportion of activated form of FVII. This mutant form of hFVII may be used for gene therapy of hemophilia.

  3. Contextos cerámicos de los siglos V-VII en Cartagena

    Directory of Open Access Journals (Sweden)

    Ramallo Asensio, Sebastián F.

    1996-12-01

    Full Text Available The excavations realized in the Roman theatre of Cartagena have documented a wide stratigraphie sequence with covers levels from IInd century B.C. to today. The material contexts of Vth to VIIth B.C. are specially interesting because they were associated with considerable removals of the town planning. The construction of a comercial site in the second half of the Vth century, markets and stores, built on a big exedra with portico and 15 divisions in line, represents the total use of the theatre, the structures of which became fossilized, in part, in a new shape. A village of Byzantin age was built over both constructions, characterized with quadrangular rooms which alternates with opened public spaces and irregular streets adjusted to the artificial and inclined topography dependent on the precedent constructions.Las excavaciones realizadas en el teatro romano de Cartagena han documentado una amplia secuencia estratigráfica que abarca desde niveles del siglo II a. de C. hasta nuestros días. Especialmente interesantes son los contextos materiales de los siglos V al VII, asociados a profundas remociones de carácter urbanístico. La construcción en la segunda mitad del siglo V de un complejo comercial, mercado/almacén, estructurado sobre una gran exedra porticada y una serie de 15 compartimentos alineados, representa la amortización total del edificio del teatro cuyas estructuras en parte fosiliza el nuevo conjunto. Encima de ambas construcciones se construyó un barrio de época bizantina caracterizado por habitaciones de forma cuadrangular que alternan con espacios comunes abiertos y calles de trazado irregular adaptadas a la topografía artificial y en pendiente impuesta por las construcciones precedentes.

  4. Recombinant-activated factor VII in patients with uncontrolled bleeding: A retrospective observational analysis

    Directory of Open Access Journals (Sweden)

    Said D Abuhasna

    2012-01-01

    Full Text Available Background: Factor VIIa (recombinant has an off-label use to control life-threatening bleeding that is refractory to other measures and was shown to decrease transfusion requirements. Objective: The primary objective of this study was to assess the safety and effectiveness of factor VIIa (recombinant on blood transfusion requirements and coagulation parameters when used in patients whose bleeding was uncorrected by other means. The pharmacoeconomic impact for any discrepancy from our protocol was evaluated. Secondary outcomes included 4-hour and 28-day mortality, as well as safety of this agent in terms of thromboembolic complications. Materials and Methods: We retrospectively evaluated patients who received recombinant-activated factor VII (rFVIIa for uncontrolled bleeding from June 2008 to April 2011. The medical records of 33 patients were evaluated. Coagulation parameters and blood products were determined 24 hours before and 24 hours after administration of rFVIIa, and the results compared. Patients were also screened for any thromboembolic complications. Results: Administration of rFVIIa reduced blood transfusion requirements and improved coagulation parameters significantly (P<0.05. No thromboembolic complications were reported. Most of the dosing was consistent with those recommended in our institutional protocol, with discrepancies resulting in an average cost of $56 058. Moreover, pH was reported in only 67% of patients. All patients treated with rFVIIa survived up to 4 hours after receiving this agent, while the 28-day mortality was 24% (8/33. Conclusion: The use of rFVIIa appears to be safe and effective in promoting hemostasis, as evident from reducing transfusion requirements and improving the coagulation variables.

  5. Commencement Bay Study. Volume VII. Sediments, Noise, Climate, and Air Quality, Aesthetics, Birds.

    Science.gov (United States)

    1981-12-31

    Passeriformes VI. Sand-spit at mouth of Puyallup River numerous shore birds feeding Western Grede-large flocks Double Crested Cormorant-spring only...L Of S.AN3ARDSl V-0 ICOMMENCEMENT BAY STUDY ~~ Sediments Noise Climate, and Air Qualt Aesthetics Birds .. . . ... . . .......... 2..... VV.X D0O~U~T...Sediments, Noise, Climate 5. PERFORMING ORG. REPORT NUMBER and Air Quality, Birds 682-021-05 7. AUTHOR(*) S. CONTRACT OR GRANT NUMBR(s) DACW67-80-C

  6. Exercise Desert Rock VII. Operation Order Number 2. Army, Camp Desert Rock, Nevada.

    Science.gov (United States)

    1957-05-15

    Safe Program. (3) A3- selected observers will possess a valid SCRET security Clearance. Security rosters by vehicle will be prepared by S-3 (and certi...Mercury Hwy marked by - white top stnkes Dirt Road-- gG~at Imile - - - - I S on Hwy sre * Parking Area Distributionsg Special 354.U5 25 M~. 57 WFICIALs...0 2 Mops IZVAD4, 1350,000, TI2’IPAH SPRINM, CA SPRINGS, PAPOOS LAE and FBENCHKAN LAIM Shoots. ’-I’ , f Trail off Mercury Huy marked by . , white top

  7. Biogeographic Congruency among Bacterial Communities from Terrestrial Sulfidic Springs

    Directory of Open Access Journals (Sweden)

    Brendan eHeadd

    2014-09-01

    Full Text Available Terrestrial sulfidic springs support diverse microbial communities by serving as stable conduits for geochemically diverse and nutrient-rich subsurface waters. Microorganisms that colonize terrestrial springs likely originate from groundwater, but may also be sourced from the surface. As such, the biogeographic distribution of microbial communities inhabiting sulfidic springs should be controlled by a combination of spring geochemistry and surface and subsurface transport mechanisms, and not necessarily geographic proximity to other springs. We examined the bacterial diversity of seven springs to test the hypothesis that occurrence of taxonomically similar microbes, important to the sulfur cycle, at each spring is controlled by geochemistry. Complementary Sanger sequencing and 454 pyrosequencing of 16S rRNA genes retrieved five proteobacterial classes, and Bacteroidetes, Chlorobi, Chloroflexi, and Firmicutes phyla from all springs, which suggested the potential for a core sulfidic spring microbiome. Among the putative sulfide-oxidizing groups (Epsilonproteobacteria and Gammaproteobacteria, up to 83% of the sequences from geochemically similar springs clustered together. Abundant populations of Hydrogenimonas-like or Sulfurovum-like spp. (Epsilonproteobacteria occurred with abundant Thiothrix and Thiofaba spp. (Gammaproteobacteria, but Arcobacter-like and Sulfurimonas spp. (Epsilonproteobacteria occurred with less abundant gammaproteobacterial populations. These distribution patterns confirmed that geochemistry rather than biogeography regulates bacterial dominance at each spring. Potential biogeographic controls were related to paleogeologic sedimentation patterns that could control long-term microbial transport mechanisms that link surface and subsurface environments. Knowing the composition of a core sulfidic spring microbial community could provide a way to monitor diversity changes if a system is threatened by anthropogenic processes or

  8. Comparative germination of Tamarix ramosissima spring and summer seeds

    OpenAIRE

    Yan, Cheng; Wei, Yan; Yang, Meilin

    2011-01-01

    Tamarix ramosissima has bi-seasonal flowering and fruit-setting characteristics. This study compared the morphology and germination characteristics of seeds from Tamarix ramosissima plants during the spring flowering period and the summer flowering period. The results are as follows: there is no significant difference in morphology, such as size and thousand-seed weight, between seeds from different the spring and summer flowering periods. Freshly harvested spring and summer flowering period ...

  9. Effects of springs on a pendulum electromechanical energy harvester

    Directory of Open Access Journals (Sweden)

    Arnaud Notué Kadjie

    2014-01-01

    Full Text Available This paper studies a model of energy harvester that consists of an electromechanical pendulum system subjected to nonlinear springs. The output power is analyzed in terms of the intrinsic parameters of the device leading to optimal parameters for energy harvesting. It is found that in an appropriate range of the springs constant, the power attains higher values as compared to the case without springs. The dynamical behavior of the device shows transition to chaos.

  10. Closure of large midline diastema by a "HIV-Spring".

    Science.gov (United States)

    Harikrishnan, Pandurangan

    2015-01-01

    Midline diastema is a common orthodontic problem in mixed dentition caused by various factors like genetic, supernumery teeth, abnormal frenum attachment, habits and microdontia etc. Large diastemas need closure for the eruption of adjacent teeth. I present here a newly designed customized self active HIV-Spring (Hari Inverted 'V' Spring) for closing a large diastema with minimum orthodontic materials and less activation visits. The spring can be modfied for the three dimensional movement of central incisors.

  11. Analysis of Composite Leaf Spring Enhanced With Nanoparticles

    Directory of Open Access Journals (Sweden)

    K. Ganesan

    2015-12-01

    Full Text Available Weight reduction is now the main issue in automobile industries. In this work due to reduce the weight of steel spring with composite leaf spring due to high strength ratio is need to improve. The main aim is to compare to the load carrying capacity, stiffness and weight savings of composite leaf spring with that of steel leaf spring at rated-load and over-load condition. The analysis has been carried out for the leaf spring made up of steel and Composite materials. Composite specimens are fabricated with two different staking sequences like the (resin with clay and enhanced with Nanoparticles. The thickness and width for constant cross section is maintained on the moulding techniques. The design of multi leaf spring was modeled in PRO-E and imported in ANSYS 14.5.the dimensions of an existing multi leaf spring is taken for modeling and analysis of a laminated composite multi leaf spring with different composite sequence materials subjected to the same load as that of steel spring.

  12. Analytical Technique of Selection of Constructive Parameters Pneumatichydraulic Springs

    Directory of Open Access Journals (Sweden)

    A. A. Tsipilev

    2014-01-01

    Full Text Available The article "Technique for Analytical Selection of Design Parameters of Pneumatichydraulic Springs concerns the ride smoothness of high-speed vehicles. Author of article Tsipilev A.A. is an assistant at chair "Multi-purpose Tracked Vehicles and Mobile Robots" of BMSTU. The article represents a synthesis of known information on the springing systems and an analysis of relation between spring design data and running gear. It describes standard units of running gear of vehicle in the context of springing systems. Classification of springing systems is considered. Modernization general policy for existing suspensions and prospects for creation of new ones are given. The article considers a design of various pneumatic-hydraulic springs to be set on domestic tracked vehicles. A developed technique allows us to have elastic characteristics of pneumatic-hydraulic springs of various types using these design data and kinematics of the running gear. The article provides recommendations to calculate characteristics of springing systems. The adequacy analysis of the given technique based on the comparison of real and rated characteristics of the existing suspension is conducted. This article can be useful to the experts dealing with springing systems of wheel and tracked vehicles.

  13. MEMS Variable Stiffness Spring and Its Application in Fuze

    Directory of Open Access Journals (Sweden)

    Li Sui

    2014-04-01

    Full Text Available MEMS processing technology can manufacture any complex structures in a plane, using this point, a variable stiffness design idea for the planar micro-spring is proposed. That is, using one type of structure named contact pairs to achieve stiffness change during the micro-spring’s stretching process. Using contact pairs, three types of variable stiffness springs are designed: stiffness increase spring, stiffness decrease spring and stiffness hump spring. Finally, the variable stiffness springs’ application for fuze setback arming device is discussed. When the three types of springs are used in setback arming device, the stiffness decrease spring is better than the other two springs from security analysis. Kinematic analysis shows that, if the variable stiffness spring’s design is reasonable, the setback arming device not only can effectively solve the safety and reliability issues for rocket fuze, but also applies in small caliber grenade fuze’s working environment without changing the setback arming device’s size and structure. Analysis result indicate that the setback arming device based on MEMS variable stiffness spring is universal for rocket fuze and small caliber grenade fuze.

  14. Monolithic geometric anti-spring blades

    Energy Technology Data Exchange (ETDEWEB)

    Cella, G. [Universita di Pisa, Pisa (Italy); Sannibale, V. [LIGO Project, California Institute of Technology, 1200 E. California Blvd, Pasadena, CA 91125 (United States)]. E-mail: sannibale_v@ligo.caltech.edu; DeSalvo, R. [LIGO Project, California Institute of Technology, 1200 E. California Blvd, Pasadena, CA 91125 (United States); Marka, S. [LIGO Project, California Institute of Technology, 1200 E. California Blvd, Pasadena, CA 91125 (United States); Takamori, A. [University of Tokyo, Tokyo (Japan)

    2005-03-21

    In this article we investigate the principle and properties of a vertical passive seismic noise attenuator conceived for ground based gravitational wave interferometers. This mechanical attenuator based on a particular geometry of cantilever blades called monolithic geometric anti springs (MGAS) permits the design of mechanical harmonic oscillators with very low resonant frequency (below 10 mHz). Here we address the theoretical description of the mechanical device, focusing on the most important quantities for the low-frequency regime, on the distribution of internal stresses, and on the thermal stability. In order to obtain physical insight of the attenuator peculiarities, we devise some simplified models, rather than use the brute force of finite element analysis. Those models have been used to optimize the design of a seismic attenuation system prototype for LIGO advanced configurations and for the next generation of the TAMA interferometer.

  15. Hot Springs-Garrison Fiber Optic Project

    Energy Technology Data Exchange (ETDEWEB)

    1994-10-01

    Bonneville Power Administration (BPA) is proposing to upgrade its operational telecommunications system between the Hot Springs Substation and the Garrison Substation using a fiber optic system. The project would primarily involve installing 190 kilometers (120 miles) of fiber optic cable on existing transmission structures and installing new fiber optic equipment in BPA`s substation yards and control houses. BPA prepared an environmental assessment (EA) evaluating the proposed action. This EA was published in October 1994. The EA identifies a number of minor impacts that might occur as a result of the proposed action, as well as some recommended mitigation measures. This Mitigation Action Plan (MAP) identifies specific measures to avoid, minimize, or compensate for impacts identified in the EA.

  16. Spectral characteristics of spring arctic mesosphere dynamics

    Directory of Open Access Journals (Sweden)

    C. M. Hall

    1998-12-01

    Full Text Available The spring of 1997 has represented a stable period of operation for the joint University of Tromsø / University of Saskatchewan MF radar, being between refurbishment and upgrades. We examine the horizontal winds from the February to June inclusive and also include estimates of energy dissipation rates derived from signal fading times and presented as upper limits on the turbulent energy dissipation rate, ε. Here we address the periodicity in the dynamics of the upper mesosphere for time scales from hours to one month. Thus, we are able to examine the changes in the spectral signature of the mesospheric dynamics during the transition from winter to summer states.Key words. Meteorology and atmospheric dynamics (middle atmosphere dynamics; turbulence; waves and tides.

  17. Submarine thermal springs on the Galapagos Rift

    Science.gov (United States)

    Corliss, J.B.; Dymond, J.; Gordon, L.I.; Edmond, J.M.; Von Herzen, R. P.; Ballard, Richard D.; Green, K.; Williams, D.; Bainbridge, A.; Crane, K.; Van Andel, T. H.

    1979-01-01

    The submarine hydrothermal activity on and near the Galápagos Rift has been explored with the aid of the deep submersible Alvin. Analyses of water samples from hydrothermal vents reveal that hydrothermal activity provides significant or dominant sources and sinks for several components of seawater; studies of conductive and convective heat transfer suggest that two-thirds of the heat lost from new oceanic lithosphere at the Galápagos Rift in the first million years may be vented from thermal springs, predominantly along the axial ridge within the rift valley. The vent areas are populated by animal communities. They appear to utilize chemosynthesis by sulfur-oxidizing bacteria to derive their entire energy supply from reactions between the seawater and the rocks at high temperatures, rather than photosynthesis

  18. Weed suppression ability of spring barley varieties

    DEFF Research Database (Denmark)

    Christensen, Svend

    1995-01-01

    Three years of experiments with spring barley showed significant differences in weed suppression ability among varieties. Weed dry matter in the most suppressive variety, Ida, was 48% lower than the mean weed dry matter of all varieties, whereas it was 31% higher in the least suppressive variety......, Grit. Ranking varietal responses to weed competition in terms of grain yield loss corresponded well to ranking weed dry matter produced in crop weed mixtures. There was no correspondence between the varietal grain yields in pure stands and their competitiveness, suggesting that breeding to optimize...... interception model was developed to describe the light interception profiles of the varieties. A study of the estimated parameters showed significant correlation between weed dry matter, rate of canopy height development and the light interception profile. However, when estimates were standardized to eliminate...

  19. Okanogan Basin Spring Spawner Report for 2007.

    Energy Technology Data Exchange (ETDEWEB)

    Colville Tribes, Department of Fish & Wildlife

    2007-09-01

    The Okanogan Basin Monitoring and Evaluation Program collected data related to spring spawning anadromous salmonid stocks across the entire Okanogan River basin. Data were collected using redd surveys, traps, underwater video, and PIT-tag technology then summarized and analyzed using simple estimate models. From these efforts we estimated that 1,266 summer steelhead spawned in the Okanogan River basin and constructed 552 redds;152 of these fish where of natural origin. Of these, 121 summer steelhead, including 29 of natural origin, created an estimated 70 redds in the Canadian portion of the Okanagan basin. We estimated summer steelhead spawner escapement into each sub-watershed along with the number from natural origin and the number and density of redds. We documented redd desiccation in Loup Loup Creek, habitat utilization in Salmon Creek as a result of a new water lease program, and 10 spring Chinook returning to Omak Creek. High water through most of the redd survey period resulted in development of new modeling techniques and allowed us to survey additional tributaries including the observation of summer steelhead spawning in Wanacut Creek. These 2007 data provide additional support that redd surveys conducted within the United States are well founded and provide essential information for tracking the recovery of listed summer steelhead. Conversely, redd surveys do not appear to be the best approach for enumerating steelhead spawners or there distribution within Canada. We also identified that spawning distributions within the Okanogan River basin vary widely and stocking location may play an over riding roll in this variability.

  20. Geothermal Exploration in Hot Springs, Montana

    Energy Technology Data Exchange (ETDEWEB)

    Toby McIntosh, Jackola Engineering

    2012-09-26

    The project involves drilling deeper in the Camp Aqua well dri lled in June 1982 as part of an effort to develop an ethanol plant. The purpose of the current drill ing effort is to determine if water at or above 165°F exists for the use in low temperature resource power generation. Previous geothermal resource study efforts in and around Hot Springs , MT and the Camp Aqua area (NE of Hot Springs) have been conducted through the years. A confined gravel aquifer exists in deep alluvium overlain by approximately 250 of si lt and c lay deposits from Glacial Lake Missoula. This gravel aquifer overlies a deeper bedrock aquifer. In the Camp Aqua area several wel l s exist in the gravel aquifer which receives hot water f rom bedrock fractures beneath the area. Prior to this exploration, one known well in the Camp Aqua area penetrated into the bedrock without success in intersecting fractures transporting hot geothermal water. The exploration associated with this project adds to the physical knowledge database of the Camp Aqua area. The dri l l ing effort provides additional subsurface information that can be used to gain a better understanding of the bedrock formation that i s leaking hot geothermal water into an otherwise cold water aquifer. The exi s t ing well used for the explorat ion is located within the center of the hottest water within the gravel aquifer. This lent i t sel f as a logical and economical location to continue the exploration within the existing well. Faced with budget constraints due to unanticipated costs, changing dril l ing techniques stretched the limited project resources to maximize the overa l l well depth which f e l l short of original project goals. The project goal of finding 165°F or hotter water was not achieved; however the project provides additional information and understanding of the Camp Aqua area that could prove valuable in future exploration efforts

  1. Mineralogy of saline perennial cold springs on Axel Heiberg Island, Nunavut, Canada and implications for spring deposits on Mars

    Science.gov (United States)

    Battler, Melissa M.; Osinski, Gordon R.; Banerjee, Neil R.

    2013-06-01

    In recent years evidence for spring deposits on Mars has been mounting. It seems increasingly likely that groundwater upwelling and surfacing as springs may be responsible for some mineral deposits on Mars' surface. In order to more easily detect and better understand potential spring deposits on Mars, it is pertinent that we gain a better understanding of the distribution of minerals at cold spring systems on Earth. Here, we report on the detailed mineralogy and distribution of precipitates in crusts and sediments of three non-volcanic perennial saline cold spring systems associated with gypsum/anhydrite diapirs on Axel Heiberg Island, Canada: Wolf spring (WS; also known as Lost Hammer), Colour Peak springs (CP), and Gypsum Hill springs (GH). At these sites permafrost, frigid winter temperatures, and arid atmospheric conditions approximate conditions of present-day, as well as past, Mars. Mineralogy of the three springs is dominated by halite (NaCl), calcite (CaCO3), gypsum (CaSO4·2H2O), thenardite (Na2SO4), mirabilite (Na2SO4·10H2O), and elemental sulfur (S°). Minerals at WS are more sodium-rich than at the other two sites, and water salinity is much higher, suggesting water flows through halite in the subsurface. Mirabilite is likely deposit at WS during winter months and dehydrates to thenardite during summer months. Elemental sulfur is typically associated with gypsum, and may be related to microbial metabolism. Spring sediments are home to thriving microbial communities in winter and summer months, and presumably year round. If spring systems did exist on the surface of Mars, they may represent environments capable of supporting microbial life. It is not known to what extent mineral crusts in cold saline spring systems on Earth preserve evidence of microbial life, or if they ever did on Mars. Therefore, studying terrestrial saline spring mineral deposits such as those on Axel Heiberg Island may help us to better understand cold spring precipitation on Mars

  2. Comparison of student's learning achievement through realistic mathematics education (RME) approach and problem solving approach on grade VII

    Science.gov (United States)

    Ilyas, Muhammad; Salwah

    2017-02-01

    The type of this research was experiment. The purpose of this study was to determine the difference and the quality of student's learning achievement between students who obtained learning through Realistic Mathematics Education (RME) approach and students who obtained learning through problem solving approach. This study was a quasi-experimental research with non-equivalent experiment group design. The population of this study was all students of grade VII in one of junior high school in Palopo, in the second semester of academic year 2015/2016. Two classes were selected purposively as sample of research that was: year VII-5 as many as 28 students were selected as experiment group I and VII-6 as many as 23 students were selected as experiment group II. Treatment that used in the experiment group I was learning by RME Approach, whereas in the experiment group II by problem solving approach. Technique of data collection in this study gave pretest and posttest to students. The analysis used in this research was an analysis of descriptive statistics and analysis of inferential statistics using t-test. Based on the analysis of descriptive statistics, it can be concluded that the average score of students' mathematics learning after taught using problem solving approach was similar to the average results of students' mathematics learning after taught using realistic mathematics education (RME) approach, which are both at the high category. In addition, It can also be concluded that; (1) there was no difference in the results of students' mathematics learning taught using realistic mathematics education (RME) approach and students who taught using problem solving approach, (2) quality of learning achievement of students who received RME approach and problem solving approach learning was same, which was at the high category.

  3. Rat model for dominant dystrophic epidermolysis bullosa: glycine substitution reduces collagen VII stability and shows gene-dosage effect.

    Directory of Open Access Journals (Sweden)

    Alexander Nyström

    Full Text Available Dystrophic epidermolysis bullosa, a severely disabling hereditary skin fragility disorder, is caused by mutations in the gene coding for collagen VII, a specialized adhesion component of the dermal-epidermal junction zone. Both recessive and dominant forms are known; the latter account for about 40% of cases. Patients with dominant dystrophic epidermolysis bullosa exhibit a spectrum of symptoms ranging from mild localized to generalized skin manifestations. Individuals with the same mutation can display substantial phenotypic variance, emphasizing the role of modifying genes in this disorder. The etiology of dystrophic epidermolysis bullosa has been known for around two decades; however, important pathogenetic questions such as involvement of modifier genes remain unanswered and a causative therapy has yet to be developed. Much of the failure to make progress in these areas is due to the lack of suitable animal models that capture all aspects of this complex monogenetic disorder. Here, we report the first rat model of dominant dystrophic epidermolysis bullosa. Affected rats carry a spontaneous glycine to aspartic acid substitution, p.G1867D, within the main structural domain of collagen VII. This confers dominant-negative interference of protein folding and decreases the stability of mutant collagen VII molecules and their polymers, the anchoring fibrils. The phenotype comprises fragile and blister-prone skin, scarring and nail dystrophy. The model recapitulates all signs of the human disease with complete penetrance. Homozygous carriers of the mutation are more severely affected than heterozygous ones, demonstrating for the first time a gene-dosage effect of mutated alleles in dystrophic epidermolysis bullosa. This novel viable and workable animal model for dominant dystrophic epidermolysis bullosa will be valuable for addressing molecular disease mechanisms, effects of modifying genes, and development of novel molecular therapies for patients

  4. Arab Spring vs. Zero Problems Policy Impact of the Arab Spring on Trade Expansion of Turkey

    Directory of Open Access Journals (Sweden)

    Engin Sorhun

    2013-10-01

    Full Text Available Although Turkey has historically concentrated its trade with the European Union (EU it has diversified its trade markets with the neighbouring regions and different group of countries during the last decade. Among them, Arab countries have come into prominence. Especially, following the “zero problems with neighbours” policy (ZPN, pursued by Turkey since 2002, the trade volume with the Middle Eastern neighbours has increased faster than that with its traditional partners. Nevertheless so called “Arab Spring” has started to manifest its effects on this trend. It deteriorates not only the economies of the concerned countries but also Turkey’s trade expansion. This paper aims: (i to test through a gravity model the positive impacts of the ZPN policy and the negative impact of the Arab Spring on the trade expansion with the Spring Countries; and (ii to reveal the positive impact of the policy change and the negative impact of the uprising movements on the realization of trade potential by Turkey in the Spring Countries.

  5. Portrait of a Geothermal Spring, Hunter’s Hot Springs, Oregon

    Science.gov (United States)

    Castenholz, Richard W.

    2015-01-01

    Although alkaline Hunter’s Hot Springs in southeastern Oregon has been studied extensively for over 40 years, most of these studies and the subsequent publications were before the advent of molecular methods. However, there are many field observations and laboratory experiments that reveal the major aspects of the phototrophic species composition within various physical and chemical gradients of these springs. Relatively constant temperature boundaries demark the upper boundary of the unicellular cyanobacterium, Synechococcus at 73–74 °C (the world-wide upper limit for photosynthesis), and 68–70 °C the upper limit for Chloroflexus. The upper limit for the cover of the filamentous cyanobacterium, Geitlerinema (Oscillatoria) is at 54–55 °C, and the in situ lower limit at 47–48 °C for all three of these phototrophs due to the upper temperature limit for the grazing ostracod, Thermopsis. The in situ upper limit for the cyanobacteria Pleurocapsa and Calothrix is at ~47–48 °C, which are more grazer-resistant and grazer dependent. All of these demarcations are easily visible in the field. In addition, there is a biosulfide production in some sections of the springs that have a large impact on the microbiology. Most of the temperature and chemical limits have been explained by field and laboratory experiments. PMID:25633225

  6. Portrait of a Geothermal Spring, Hunter’s Hot Springs, Oregon

    Directory of Open Access Journals (Sweden)

    Richard W. Castenholz

    2015-01-01

    Full Text Available Although alkaline Hunter’s Hot Springs in southeastern Oregon has been studied extensively for over 40 years, most of these studies and the subsequent publications were before the advent of molecular methods. However, there are many field observations and laboratory experiments that reveal the major aspects of the phototrophic species composition within various physical and chemical gradients of these springs. Relatively constant temperature boundaries demark the upper boundary of the unicellular cyanobacterium, Synechococcus at 73–74 °C (the world-wide upper limit for photosynthesis, and 68–70 °C the upper limit for Chloroflexus. The upper limit for the cover of the filamentous cyanobacterium, Geitlerinema (Oscillatoria is at 54–55 °C, and the in situ lower limit at 47–48 °C for all three of these phototrophs due to the upper temperature limit for the grazing ostracod, Thermopsis. The in situ upper limit for the cyanobacteria Pleurocapsa and Calothrix is at ~47–48 °C, which are more grazer-resistant and grazer dependent. All of these demarcations are easily visible in the field. In addition, there is a biosulfide production in some sections of the springs that have a large impact on the microbiology. Most of the temperature and chemical limits have been explained by field and laboratory experiments.

  7. Un protector laminado de brazo (manica) procedente del campamento de la legio VII Gemina en León

    OpenAIRE

    Aurrecoechea, Joaquín; Fernández Ibáñez, Carmelo; García Marcos, Victorino; Morillo, Ángel

    2008-01-01

    Las excavaciones arqueológicas desarrolladas durante 1998 en un solar de la calle Santa Marina, inmediato a la cara interna de la muralla bajoimperial de León, revelaron un gran edificio perteneciente al campamento de la legio VII gemina, que ha sido identificado como un almacén con patio central, levantado a finales del siglo I d. C. En el interior de una de las estancias se encontró un fragmento de manica o protector laminado de brazo. Este elemento está constituido por 11 láminas imbric...

  8. PENGARUH METODE DISCOVERY LEARNING TERHADAP KEAKTIFAN BELAJAR SISWA (STUDI QUASI EKSPERIMEN KELAS VII SMPN 6 BANDA ACEH

    Directory of Open Access Journals (Sweden)

    Yulia Ayuningsih Salo

    2016-12-01

    Full Text Available Penelitian ini bertujuan untuk memperoleh suatu rancangan pembelajaran dengan menggunakan metode discovery learning untuk meningkatkan keaktifan belajar siswa. Penelitian ini dilaksanakan di SMPN 6 Banda Aceh. Metode penelitian yang digunakan adalah quasi eksperimen. Subjek penelitian adalah siswa SMPN 6 Banda Aceh yang berjumlah 60 orang. Analisis dilakukan dengan menggunakan perangkat lunak Ms. Excel dan SPSS. Hasil penelitiaan menunjukan bahwa gambaran umum keaktifan belajar siswa kelas VII SMPN 6 Banda Aceh termasuk pada katagori sedang. Berdasarkan analisis data ditemukan terdapat perbedaan pengaruh keaktifan belajar kelompok eksperimen dan kontrol secara signifikan.

  9. PENGEMBANGAN PERANGKAT PEMBELAJARAN BERCIRIKAN KONSTRUKTIVIS TIPE GAGNON DAN COLLAY PADA MATERI PENYAJIAN DATA UNTUK SISWA KELAS VII

    Directory of Open Access Journals (Sweden)

    Rani Puspita Rahayu

    2016-07-01

    Tujuan penelitian ini adalah mendeskripsikan proses pengembangan perangkat pembelajaran dan menghasilkan perangkat pembelajaran bercirikan konstruktivis tipe Gagnon dan Collay pada materi penyajian data untuk siswa kelas VII dengan kriteria valid, praktis dan efektif. Penelitian pengembangan ini menggunakan model Plomp. Hasil validasi diperoleh perangkat pembelajaran yang valid, perangkat pembelajaran memenuhi kriteria keprakisan yaitu aktivitas guru dalam pembelajaran masuk dalam kategori baik, serta memenuhi kriteria keefektifan, yaitu (1 tercapai ketuntasan klasikal; (2 aktivitas siswa dalam pembelajaran masuk dalam kategori baik; (3 respon siswa positif. Sehingga pengembangan perangkat pembelajaran memenuhi kriteria valid, praktis, dan efektif.

  10. PENGARUH MODEL PEMBELAJARAN INKUIRI TERBIMBING BERBASIS LINGKUNGAN TERHADAP KETERAMPILAN PROSES DAN PENGUASAAN KONSEP IPA SISWA KELAS VII PADA MATERI EKOSISTEM

    Directory of Open Access Journals (Sweden)

    Dedy Hariyadi

    2016-08-01

    Tujuan penelitian ini adalah untuk mengetahui pengaruh model pembelajaran inkuiri terbimbing berbasis lingkungan terhadap keterampilan proses dan penguasaan konsep IPA siswa pada materi ekosistem. Penelitian ini menggunakan rancangan eksperimental semu. Populasi dalam penelitian ini adalah siswa kelas VII SMP Negeri 4 Kopang yang berjumlah dua kelas dimana seluruh populasi dijadikan sampel. Instrumen yang digunakan berupa tes uraian untuk mengukur keterampilan proses dan tes pilihan ganda untuk mengukur penguasaan konsep siswa. Hasil penelitian menunjukkan bahwa terdapat perbedaan keterampilan proses dan penguasaan konsep IPA siswa antara siswa yang dibelajarkan dengan model inkuiri terbimbing berbasis lingkungan dengan siswa yang dibelajarkan dengan pembelajaran konvensional.

  11. Salvage use of activated recombinant factor VII in the management of refractory bleeding following cardiac surgery

    Directory of Open Access Journals (Sweden)

    Barua A

    2011-09-01

    Full Text Available Anupama Barua1, Vinay P Rao1, BC Ramesh2, Biplab Barua3, Hussain El-Shafei21Cardiothoracic Department, Nottingham City Hospital, Nottingham, UK; 2Cardiothoracic Department, Aberdeen Royal Infirmary, Aberdeen, UK; 3General Surgery Department, Glenfield Hospital, Glenfield, Leicester, UKBackground: Refractory post cardiopulmonary bypass (CPB bleeding continues to cause concern for cardiac surgeons and intensivists. Massive postoperative hemorrhage following CPB is multifactorial and not fully understood, and it is also associated with increased mortality and morbidity. Activated recombinant factor VII (rFVIIa has emerged as possible salvage medication in refractory post cardiac surgical bleeding. This observational study sought to identify the pattern of use of rFVIIa in cardiac surgery, its effectiveness, and risk.Methods: This study involved a retrospective case review of medical records of ten patients undergoing a variety of cardiac surgery procedures and who developed life-threatening bleeding during surgery or after surgery despite conventional medical therapy, including transfusion of blood and blood products, and received rFVIIa at a regional center between August 2007 and April 2009.Results: All ten patients received two consecutive doses of rFVIIa (average dose 65 µg/kg at a 2-hour interval. Eight patients were re-explored due to massive postoperative bleeding or cardiac tamponade before receiving rFVIIa. Surgical sources of bleeding were not identified in any cases. A second re-exploration was carried out in two cases. Two patients (20% died in ITU from problems not related to bleeding and thromboembolism. Blood loss was significantly reduced after administration of rFVIIa. Blood loss 6 hours prior to treatment was 1758.5 ± 163.9 mL and blood loss in the 6-hour period post treatment was 405.6 ± 50.5 mL (P < 0.05. Blood and blood products used in the 6-hour period before and after administration of rFVIIa were 19.6 ± 1.5U and 4.4

  12. CRÔNICA DE EVENTOS - VII SEMINÁRIO ANPTUR 2010

    Directory of Open Access Journals (Sweden)

    Elizabeth Kyoko Wada

    2011-05-01

    Full Text Available O VII Seminário ANPTUR 2010 foi realizado em 20 e 21 de setembro de 2010 e discutiu o tema Ética: Produção e Difusão da Pesquisa em Turismo. O objetivo principal foi o de disseminar os resultados de pesquisas concluídas ou em andamento como contribuição ao avanço do conhecimento científico do Turismo e áreas afins. Além disso, teve o propósito de reunir a comunidade científica da área para análise e discussão das questões éticas implicadas na produção e divulgação da pesquisa, para que o crescimento e consolidação acadêmica do campo do Turismo, Hospitalidade, Lazer e área afins venha acompanhado da necessária seriedade e profundidade em termos teóricos e metodológicos bem como pelo respeito para com os pares. Houve 245 participantes, sendo a maioria (62,5% de autores de trabalhos, portanto pesquisadores, mestres, doutores, docentes e/ou discentes de programas de pós-graduação stricto sensu. Todos os coordenadores dos Programas filiados à ANPTUR estavam presentes ou se fizeram representar. Estiveram representadas 75 Instituições e Entidades, de 24 Estados Brasileiros, além do Distrito Federal, bem como 8 instituições do exterior, de 7 países diferentes. A sétima edição do Seminário ANPTUR foi marcada pelo esforço de organização e estruturação do evento quanto ao seu caráter científico, a partir de um trabalho conjunto da Diretora Executiva da Associação e também de todos os seus membros efetivos e associados. Os resultados obtidos demonstram que a comunidade científica em Turismo já adota uma postura científica, crítica e reflexiva no desenvolvimento das pesquisas, as quais vêm contribuindo ao avanço do conhecimento científico e suas aplicações na realidade turística brasileira, priorizando a sustentabilidade, a responsabilidade social, a interdisciplinaridade e a ética.

  13. Response matrix calculation of a Bonner Sphere Spectrometer using ENDF/B-VII libraries

    Energy Technology Data Exchange (ETDEWEB)

    Morató, Sergio; Juste, Belén; Miró, Rafael; Verdú, Gumersindo [Instituto de Seguridad Industrial, Radiofísica y Medioambiental (ISIRYM), Universitat Politècnica de València (Spain); Guardia, Vicent, E-mail: bejusvi@iqn.upv.es [GD Energy Services, Valencia (Spain). Grupo dominguis

    2017-07-01

    The present work is focused on the reconstruction of a neutron spectra using a multisphere spectrometer also called Bonner Spheres System (BSS). To that, the determination of the response detector curves is necessary therefore we have obtained the response matrix of a neutron detector by Monte Carlo (MC) simulation with MCNP6 where the use of unstructured mesh geometries is introduced as a novelty. The aim of these curves was to study the theoretical response of a widespread neutron spectrometer exposed to neutron radiation. A neutron detector device has been used in this work which is formed by a multispheres spectrometer (BSS) that uses 6 high density polyethylene spheres with different diameters. The BSS consists of a set of 0.95 g/cm{sup 3} high density polyethylene spheres. The detector is composed of a lithium iodide 6LiI cylindrical scintillator crystal 4mm x 4mm size LUDLUM Model 42 coupled to a photomultiplier tube. Thermal tables are required to include polyethylene cross section in the simulation. These data are essential to get correct and accurate results in problems involving neutron thermalization. Nowadays available literature present the response matrix calculated with ENDF.B.V cross section libraries (V.Mares et al 1993) or with ENDF.B.VI (R.Vega Carrillo et al 2007). This work uses two novelties to calculate the response matrix. On the one hand the use of unstructured meshes to simulate the geometry of the detector and the Bonner Spheres and on the other hand the use of the updated ENDF.B.VII cross sections libraries. A set of simulations have been performed to obtain the detector response matrix. 29 mono energetic neutron beams between 10 KeV to 20 MeV were used as source for each moderator sphere up to a total of 174 simulations. Each mono energetic source was defined with the same diameter as the moderating sphere used in its corresponding simulation and the spheres were uniformly irradiated from the top of the photomultiplier tube. Some

  14. An investigation of contaminant impacts to watercress darter, Etheostama nuchale, habitat at Roebuck Springs, Thomas' Spring, and Glenn Springs, Jefferson Country, Alabama

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report summarizes a study with the following results: 1. Roebuck Springs was the only site found with contaminant loading with PAH's at levels suspected of...

  15. The Design of Reactor Internals Hold-Down Spring

    Directory of Open Access Journals (Sweden)

    Guohong Xue

    2016-01-01

    Full Text Available Hold down spring(HDS, clamped between the upper support plate flange and the core barrel flange inside a pressurized reactor vessel, is used to provide a downward force to keep the core barrel stable and from being lifted off from the vessel ledge during reactor normal operation. Spring designer used to think under certain extreme operating conditions, the spring could be lifted off from the ledge because the spring is not stiff enough to prevent the “lift-off”. Therefore, the spring was designed as stiff as it practically can be. However, finite element study indicated that the magnitude of preload is a strong function of friction coefficient. To find the magnitude of the friction coefficient, a series of tests were conducted on 1/10 scale hold down spring samples of three different spring designs. From the test results, it was found that the friction coefficient increases rapidly as the number of loading cycles increases. This implies that the spring preload would increase rapidly during plant operation. Therefore, it is concluded that, because of the strong frictional effect, not only the current design is more than adequate, but also should be made even softer.

  16. International trends in health tourism: Implications for thermal spring ...

    African Journals Online (AJOL)

    Travel to thermal springs for the sake of health and healing can be traced at least as far back as the ancient Greeks and Romans, with the earliest forms of tourism being based on apparent curative powers of mineral-rich thermal waters. There are 11 thermal springs in the Western Cape, seven of which have been ...

  17. Nano-G accelerometer using geometric anti-springs

    NARCIS (Netherlands)

    Boom, B. A.; Bertolini, A.; Hennes, E.; Brookhuis, R. A.; Wiegerink, R. J.; Van Den Brand, J. F J; Beker, M. G.; Oner, A.; Van Wees, D.

    2017-01-01

    We report an ultra-sensitive seismic accelerometer with nano-g sensitivity, using geometric anti-spring technology. High sensitivity is achieved by an on-chip mechanical preloading system comprising four sets of curved leaf springs that support a proof-mass. Using this preloading mechanism,

  18. Synergy of a warm spring and dry summer

    Science.gov (United States)

    Yude Pan; David. Schimel

    2016-01-01

    An analysis suggests that high carbon uptake by US land ecosystems during the warm spring of 2012 offset the carbon loss that resulted from severe drought over the summer — and hints that the warm spring could have worsened the drought.

  19. Geophysical and hydrogeochemical evaluation of a spring In Ado ...

    African Journals Online (AJOL)

    The ER utilized pole-pole and Schlumberger electrode arrays for profiling and Vertical Electrical Soundings (VES) respectively. A hand-dug well was sited at higher elevation and ten meters away from the spring. Microbial and physicochemical analyses were conducted on water samples from the spring and the well.

  20. Microbiological and chemical assessment of spring water from a ...

    African Journals Online (AJOL)

    Physico-chemical properties of the spring waters were mostly within the WHO benchmark for potable water. Arae had the highest total dissolved solids (TDS) value of 969 mgL-1 (benchmark, 500 mg/L), total hardness values were normal except at Arae (260 mg/L). Heavy metals levels in the spring water were generally low ...

  1. 36 CFR 7.18 - Hot Springs National Park.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Hot Springs National Park. 7.18 Section 7.18 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.18 Hot Springs National Park. (a) Commercial...

  2. Remote access and automation of SPring-8 MX beamlines

    Energy Technology Data Exchange (ETDEWEB)

    Ueno, Go, E-mail: ueno@spring8.or.jp; Hikima, Takaaki; Yamashita, Keitaro; Hirata, Kunio; Yamamoto, Masaki [RIKEN SPring-8 Center, 1-1-1 Koto, Sayo-cho, Sayo-gun, Hyogo 679-5148 JAPAN (Japan); Hasegawa, Kazuya; Murakami, Hironori; Furukawa, Yukito; Mizuno, Nobuhiro; Kumasaka, Takashi [SPring-8/JASRI, 1-1-1 Koto, Sayo-cho, Sayo-gun, Hyogo 679-5198 JAPAN (Japan)

    2016-07-27

    At SPring-8 MX beamlines, a remote access system has been developed and started user operation in 2010. The system has been developed based on an automated data collection and data management architecture utilized for the confirmed scheme of SPring-8 mail-in data collection. Currently, further improvement to the remote access and automation which covers data processing and analysis are being developed.

  3. 78 FR 18967 - Walla Walla Basin Spring Chinook Hatchery Program

    Science.gov (United States)

    2013-03-28

    ... Bonneville Power Administration Walla Walla Basin Spring Chinook Hatchery Program AGENCY: Bonneville Power... Tribes of the Umatilla Indian Reservation's (CTUIR) proposal to construct and operate a hatchery for spring Chinook salmon in the Walla Walla River basin. The hatchery would expand facilities at the site of...

  4. Formulating the spring discharge-function for the recession period ...

    Indian Academy of Sciences (India)

    Prediction of spring water availability during the recession period is the key to its proper management. ... The efficiency of the formulated master discharge function of the spring for the recession period has been ... The only feasible answer to this water scarcity problem in recession period is to store it when it is in excess ...

  5. Sobre la supuesta presencia de una inscripción de la Legio VII Gemina (CIL II, 1126 en Lucentum (Alicante = About the supposed presence of an inscription of the Legio VII Gemina (CIL II, 1126 in Lucentum (Alicante

    Directory of Open Access Journals (Sweden)

    Antonio Manuel Poveda Navarro

    2014-12-01

    Full Text Available El objetivo de este artículo es aclarar la confusión existente en identificar por error una inscripción latina del soldado romano de la Legio VII Gemina, Lucius Valerius Nepos, con la de un supuesto hallazgo en los alrededores de la ciudad romana de Lucentum, Alicante, cuando en realidad se trata de una lápida romana de dicho personaje perteneciente a la ciudad romana de Italica, Santiponce (Sevilla. De este modo es necesario eliminar dicho documento epigráfico del listado de las inscripciones conocidas de Alicante.The aim of this article is to clarify the existing confusion in mistakenly identify a Latin inscription of a Roman soldier of the Legio VII Gemina, Lucius Valerius Nepos, with an apparent finding in the surroundings of the Roman city of Lucentum, Alicante, when in fact it is a Roman tombstone of that personage and belong to the Roman city of Italica, Santiponce (Sevilla. Thereby must be remove this epigraphic document from the list of Alicantes’s known inscriptions.

  6. Groundwater conditions in Utah, spring of 2015

    Science.gov (United States)

    Burden, Carole B.

    2015-01-01

    This is the fifty-second in a series of annual reports that describe groundwater conditions in Utah. Reports in this series, published cooperatively by the U.S. Geological Survey and the Utah Department of Natural Resources, Division of Water Rights, and the Utah Department of Environmental Quality, Division of Water Quality, provide data to enable interested parties to maintain awareness of changing groundwater conditions. This report, like the others in the series, contains information on well construction, groundwater withdrawals from wells, water-level changes, precipitation, streamflow, and chemical quality of water. Information on well construction included in this report refers only to new wells constructed for withdrawal of groundwater. Supplementary data are included in reports of this series only for those years or areas that are important to a discussion of changing groundwater conditions and for which applicable data are available.This report includes individual discussions of selected significant areas of groundwater development in the State for calendar year 2014. Most of the reported data were collected by the U.S. Geological Survey in cooperation with the Utah Department of Natural Resources, Division of Water Rights, and the Utah Department of Environmental Quality, Division of Water Quality. This report is also available online at http://www.waterrights.utah.gov/techinfo/ and http://ut.water.usgs.gov/publications/GW2015.pdf. Groundwater conditions in Utah for calendar year 2013 are reported in Burden and others (2014) and are available online at http://ut.water.usgs.gov/publications/GW2014.pdf.The water-level change maps in this report show the difference between water levels measured in the same well at two distinct times: in the spring of 1985 and the spring of 2015. Throughout the state, many groundwater levels were near their peak in or around 1985 following a multiple-year period of above average precipitation in the early 1980s. Conversely

  7. Diversity of Bamboos around springs in Malang East Java

    Directory of Open Access Journals (Sweden)

    Solikin Solikin

    2014-11-01

    Full Text Available Bamboos have important roles to people in the villages area. They are planted and used by the people for making houses, food, buckets, fences, ropes, fuels, musical instruments and plaits. The root distribution of Bamboos is large and fibrous, also the growth of their new clumps is ascendant so the Bamboos has good potency for water and soil conservation on river banks, around the springs, hillsides and scarps. The survey to invent the bamboos growing around the springs was conducted in Singosari, Lawang, Karangploso, Dau and Lowokwaru Malang East Java in May 2009. The Bamboos invented at 0-100 m from the springs. The results Showed that there were four Bamboos founded around the springs namely Bambusa blumeana,Dendrocalamus asper, Gigantochloa atter and Gigantochloa apus. Dendrocalamus asper was the most dominant species founded around the springs with relative frequency, relative density and important value index is 45.83 ; 58.49 and 104.32 respectively.

  8. Diversity of Crenarchaeota in terrestrial hot springs in Tengchong, China.

    Science.gov (United States)

    Song, Zhao-Qi; Chen, Jing-Quan; Jiang, Hong-Chen; Zhou, En-Min; Tang, Shu-Kun; Zhi, Xiao-Yang; Zhang, Li-Xin; Zhang, Chuan-Lun L; Li, Wen-Jun

    2010-05-01

    Diversity of Crenarchaeota was investigated in eight terrestrial hot springs (pH 2.8-7.7; temperature 44-96 degrees C) located in Tengchong, China, using 16S rRNA gene phylogenetic analysis. A total of 826 crenarchaeotal clones were sequenced and a total of 47 operational taxonomic units (OTUs) were identified. Most (93%) of the identified OTUs were closely related (89-99%) to those retrieved from hot springs and other thermal environments. Our data showed that temperature may predominate over pH in affecting crenarchaeotal diversity in Tengchong hot springs. Crenarchaeotal diversity in moderate-temperature (59-77 degrees C) hot springs was the highest, indicating that the moderately hot-temperature springs may provide optimal conditions for speciation of Crenarchaeota.

  9. Applying spatial analysis techniques to assess the suitability of multipurpose uses of spring water in the Jiaosi Hot Spring Region, Taiwan

    Science.gov (United States)

    Jang, Cheng-Shin

    2016-04-01

    The Jiaosi Hot Spring Region is located in northeastern Taiwan and is rich in geothermal springs. The geothermal development of the Jiaosi Hot Spring Region dates back to the 18th century and currently, the spring water is processed for various uses, including irrigation, aquaculture, swimming, bathing, foot spas, and recreational tourism. Because of the proximity of the Jiaosi Hot Spring Region to the metropolitan area of Taipei City, the hot spring resources in this region attract millions of tourists annually. Recently, the Taiwan government is paying more attention to surveying the spring water temperatures in the Jiaosi Hot Spring Region because of the severe spring water overexploitation, causing a significant decline in spring water temperatures. Furthermore, the temperature of spring water is a reliable indicator for exploring the occurrence and evolution of springs and strongly affects hydrochemical reactions, components, and magnitudes. The multipurpose uses of spring water can be dictated by the temperature of the water. Therefore, accurately estimating the temperature distribution of the spring water is critical in the Jiaosi Hot Spring Region to facilitate the sustainable development and management of the multipurpose uses of the hot spring resources. To evaluate the suitability of spring water for these various uses, this study spatially characterized the spring water temperatures of the Jiaosi Hot Spring Region by using ordinary kriging (OK), sequential Gaussian simulation (SGS), and geographical information system (GIS). First, variogram analyses were used to determine the spatial variability of spring water temperatures. Next, OK and SGS were adopted to model the spatial distributions and uncertainty of the spring water temperatures. Finally, the land use (i.e., agriculture, dwelling, public land, and recreation) was determined and combined with the estimated distributions of the spring water temperatures using GIS. A suitable development strategy

  10. Stellar laboratories . VIII. New Zr iv-vii, Xe iv-v, and Xe vii oscillator strengths and the Al, Zr, and Xe abundances in the hot white dwarfs G191-B2B and RE 0503-289

    Science.gov (United States)

    Rauch, T.; Gamrath, S.; Quinet, P.; Löbling, L.; Hoyer, D.; Werner, K.; Kruk, J. W.; Demleitner, M.

    2017-03-01

    Context. For the spectral analysis of high-resolution and high-signal-to-noise spectra of hot stars, state-of-the-art non-local thermodynamic equilibrium (NLTE) model atmospheres are mandatory. These are strongly dependent on the reliability of the atomic data that is used for their calculation. Aims: To search for zirconium and xenon lines in the ultraviolet (UV) spectra of G191-B2B and RE 0503-289, new Zr iv-vii, Xe iv-v, and Xe vii oscillator strengths were calculated. This allows, for the first time, determination of the Zr abundance in white dwarf (WD) stars and improvement of the Xe abundance determinations. Methods: We calculated Zr iv-vii, Xe iv-v, and Xe vii oscillator strengths to consider radiative and collisional bound-bound transitions of Zr and Xe in our NLTE stellar-atmosphere models for the analysis of their lines exhibited in UV observations of the hot WDs G191-B2B and RE 0503-289. Results: We identified one new Zr iv, 14 new Zr v, and ten new Zr vi lines in the spectrum of RE 0503-289. Zr was detected for the first time in a WD. We measured a Zr abundance of -3.5 ± 0.2 (logarithmic mass fraction, approx. 11 500 times solar). We identified five new Xe vi lines and determined a Xe abundance of -3.9 ± 0.2 (approx. 7500 times solar). We determined a preliminary photospheric Al abundance of -4.3 ± 0.2 (solar) in RE 0503-289. In the spectra of G191-B2B, no Zr line was identified. The strongest Zr iv line (1598.948 Å) in our model gave an upper limit of -5.6 ± 0.3 (approx. 100 times solar). No Xe line was identified in the UV spectrum of G191-B2B and we confirmed the previously determined upper limit of -6.8 ± 0.3 (ten times solar). Conclusions: Precise measurements and calculations of atomic data are a prerequisite for advanced NLTE stellar-atmosphere modeling. Observed Zr iv-vi and Xe vi-vii line profiles in the UV spectrum of RE 0503-289 were simultaneously well reproduced with our newly calculated oscillator strengths. Based on observations

  11. Note: Determination of torsional spring constant of atomic force microscopy cantilevers: Combining normal spring constant and classical beam theory

    DEFF Research Database (Denmark)

    Álvarez-Asencio, R.; Thormann, Esben; Rutland, M.W.

    2013-01-01

    A technique has been developed for the calculation of torsional spring constants for AFM cantilevers based on the combination of the normal spring constant and plate/beam theory. It is easy to apply and allow the determination of torsional constants for stiff cantilevers where the thermal power...

  12. Spring pendulum with dry and viscous damping

    Science.gov (United States)

    Butikov, Eugene I.

    2015-01-01

    Free and forced oscillations of a torsion spring pendulum damped by viscous and dry friction are investigated analytically and with the help of numerical simulations. A simplified mathematical model is assumed (Coulomb law) which nevertheless can explain many peculiarities in behavior of various oscillatory systems with dry friction. The amplitude of free oscillations diminishes under dry friction linearly, and the motion stops after a final number of cycles. The amplitude of sinusoidally driven pendulum with dry friction grows at resonance without limit if the threshold is exceeded. At strong enough non-resonant sinusoidal forcing dry friction causes transients that typically lead to definite limit cycles - periodic steady-state regimes of symmetric non-sticking forced oscillations which are independent of initial conditions. However, at the subharmonic sinusoidal forcing interesting peculiarities of the steady-state response are revealed such as multiple coexisting regimes of asymmetric oscillations that depend on initial conditions. Under certain conditions simple dry friction pendulum shows complicated stick-slip motions and chaos.

  13. Preferred temperatures of Tarentola mauritanica in spring

    Directory of Open Access Journals (Sweden)

    Miguel A. Carretero

    2008-05-01

    Full Text Available Variation of the preferred temperatures (Tp by the Moorish gecko (Tarentola mauritanica in spring was analysed in a population from NE Iberia. Ten adult specimens were exposed to a thermal gradient and Tp was measured at seven time intervals between 16 and 24 h. Tp values were low (23.44 ± 0.61 ºC, 20.7-26.9 ºC, mean ± SE, range but geckoes gradually increased Tps between late afternoon and early evening. Surprisingly, mean, maximum and minimum Tps inversely correlated with the body size (SVL, but the results of the analyses remained after size correction. Compared to a previous study carried out in summer, Tps found here were much lower but diel variation persisted. Such patterns are more similar to other nocturnal or crepuscular geckonids rather than to the well-studied diurnal lacertids living in the same sites. Specifically, Tp seems to be more plastic and the relationships with body size are opposite. Possible adaptive explanations and guidelines for further work are suggested.

  14. "I just wanted to get away": An analysis of spring breakers' travel motivations

    Science.gov (United States)

    Nuno F. Ribeiro; Paul E. Durrenberger; Careen M. Yarnal; Garry E. Chick

    2010-01-01

    Scholarly research on Spring Break has grown substantially and has often associated spring breakers' motivations with a number of risky behaviors. Recent research, however, has challenged these assumptions. The purpose of this study was to examine spring breakers' motivations for going on Spring Break. Unlike the media portrayal of Spring Break as a time of...

  15. Successful use of rFVIIa for major breast surgery prophylaxis in congenital factor VII deficiency: a case report.

    Science.gov (United States)

    Varricchio, Antonio; Schettino, Michela; Ciampa, Antonio; Iannace, Carlo; Lo Conte, Domenico; Di Libero, Lorenzo; Donnarumma, Bernadette; Vigorito, Raffaella; Lepore, Mariolina

    2014-06-25

    Factor VII deficiency is a rare cause of haemorrhagic syndrome. The Authors describe a case of a 46 years old patient with congenital factor VII deficiency that successfully underwent breast surgery after treatment with Novoseven® before the procedure. The AA used the schedule reported below to value the levels of PT and aPTT in the patient. Blood Collection: Venous blood from patient and control was collected in glass tubes for routine serum preparation and into plastic tubes (0.129 M sodium citrate, Becton-Dickinson Vacutainer Systems) in a ratio of blood to anticoagulant of 9:1. Platelet Poor Plasma (PPP) was obtained by centrifugation at 4.000 x g for 15 minutes at room temperature. The plasma was recentrifuged for another 10 min at 12000 g to fully eliminate platelet concentration. A normal control plasma pool was prepared by mixing equal volumes of platelet-free plasma obtained from at least 50 normal volunteers. Prothrombin time (PT) was measured with Recombiplastin (IL, Milano Italy). Activated partial thromboplastin times (APTT) was measured with APTT-SP (IL, Milano Italy). They were performed on the coagulation analyzer ACL 1000 (IL, Milano Italy). The results were interpreted from the ratio of the patient times to the normal control times (Table I). The infusion of Novoseven solved the clotting problems enabling the surgical procedure, without risks for the patient.

  16. Development of an ELISA for rapid detection of anti-type VII collagen autoantibodies in epidermolysis bullosa acquisita.

    Science.gov (United States)

    Chen, M; Chan, L S; Cai, X; O'Toole, E A; Sample, J C; Woodley, D T

    1997-01-01

    Epidermolysis bullosa acquisita (EBA) is an acquired blistering skin disease characterized by the presence of IgG autoantibodies to type VII collagen. EBA autoantibodies recognize four major immunodominant epitopes localized within the amino-terminal, noncollagenous (NC1) domain. In this study, we developed a rapid, quantitative enzyme-linked immunosorbent assay (ELISA) to detect autoantibody activity against the complete NC1 domain of type VII collagen with the use of an eukaryotic-expressed, recombinant human NC1 antigen. With the ELISA, we tested serum from patients with EBA (n = 24), bullous systemic lupus erythematosus (BSLE) (n = 3), bullous pemphigoid (n = 16), pemphigus (n = 11), and normal controls (n = 12). All EBA and BSLE serum, including four sera that were negative by indirect immunofluorescence, demonstrated reactivity with immobilized NC1 in the ELISA. In contrast, none of the sera from healthy control subjects or patients with unrelated blistering skin diseases reacted with NC1. The EBA sera also reacted with recombinant NC1 by immunoblot analysis but with less sensitivity. Thus, the newly developed ELISA using recombinant NC1 is a sensitive, specific assay and a useful tool for rapidly screening EBA and BSLE serum.

  17. Low sensitivity of type VII collagen enzyme-linked immunosorbent assay in epidermolysis bullosa acquisita: serration pattern analysis on skin biopsy is required for diagnosis.

    Science.gov (United States)

    Terra, J B; Jonkman, M F; Diercks, G F H; Pas, H H

    2013-07-01

    The type VII collagen (coll VII) enzyme-linked immunosorbent assay (ELISA) has been reported to have high sensitivity (> 93%) and specificity (> 96%) for diagnosing epidermolysis bullosa acquisita (EBA) in patients who are seropositive on indirect immunofluorescence on salt-split skin (SSS). To investigate the added value of the coll VII ELISA in the laboratory diagnosis of SSS-positive and SSS-negative EBA and to correlate the ELISA index with disease episode. The coll VII ELISA was performed on banked sera of 28 patients with EBA: 15 SSS positive and 13 SSS negative. Sera from healthy blood donors (n = 17) and patients with other autoimmune blistering diseases (n = 29) served as controls. In four patients, the ELISA index was measured longitudinally. Serration pattern analysis by direct immunofluorescence has been prospectively performed since 2000 in 19 patients. The sensitivity in the SSS-positive group was 80% whereas it was 23% in the SSS-negative group. In the prospective EBA subset it was 45%. The sensitivity of u-serration pattern analysis on skin biopsy was 89%. Ten (53%) of these cases were seronegative with both ELISA and SSS, and would have been missed by serum analysis alone. Of the 46 control sera, one serum tested positive (specificity 97·8%). The coll VII ELISA correlated with disease activity over time in individual patients. The coll VII ELISA has limited added value in SSS-negative EBA cases. The ELISA test is valuable in differentiating EBA from antilaminin-332 mucous membrane pemphigoid and anti-p200 pemphigoid and in its ability to monitor patients with EBA serologically. U-serration pattern analysis on immunofluorescence skin biopsy is the gold standard for the diagnosis of EBA. © 2013 The Authors BJD © 2013 British Association of Dermatologists.

  18. Remineralizing efficacy of silver diamine fluoride and glass ionomer type VII for their proposed use as indirect pulp capping materials - Part II (A clinical study).

    Science.gov (United States)

    Sinha, N; Gupta, A; Logani, A; Shah, N

    2011-07-01

    To evaluate in vivo the remineralizing efficacy of silver diamine fluoride (SDF), glass ionomer Type VII (GC VII) and calcium hydroxide (Dycal). 60 subjects in the age group of 18-35 years, matching the inclusion criteria and having deep carious lesions in the permanent first and second molars were selected. The teeth were aseptically opened under rubber dam and after gross caries removal, approximately 0.4mg of soft discolored dentin was removed with a sharp spoon excavator from the mesial or distal aspect of the cavity. The test material was randomly selected and applied in a thickness of 1.5-2mm and the cavity sealed with cavit. The patients were followed up at regular intervals with radiographic evaluation at 12 weeks. At 3 months the temporary restoration was removed and dentin samples were collected from the other half of the cavity which was left in the first appointment. Atomic absorption spectrophotometry, Colorimetric test using UV-vis spectrometer and potentiometric titration were used for determining calcium, phosphorous and fluoride respectively. Almost equivalent rise in the percentage of calcium level was seen in GC VII and Ca(OH)(2) groups, followed by SDF group. Highest percentage rise in phosphate ions was seen in GC VII group followed by SDF group and Ca(OH)(2) group. Highest percentage of fluoride rise was seen in GC VII group followed by SDF group and Ca(OH)(2) group. The results indicated that both GC VII and SDF can be potential indirect pulp capping materials.

  19. Remineralizing efficacy of silver diamine fluoride and glass ionomer type VII for their proposed use as indirect pulp capping materials – Part II (A clinical study)

    Science.gov (United States)

    Sinha, N; Gupta, A; Logani, A; Shah, N

    2011-01-01

    Aim: To evaluate in vivo the remineralizing efficacy of silver diamine fluoride (SDF), glass ionomer Type VII (GC VII) and calcium hydroxide (Dycal). Materials and Methods: 60 subjects in the age group of 18-35 years, matching the inclusion criteria and having deep carious lesions in the permanent first and second molars were selected. The teeth were aseptically opened under rubber dam and after gross caries removal, approximately 0.4mg of soft discolored dentin was removed with a sharp spoon excavator from the mesial or distal aspect of the cavity. The test material was randomly selected and applied in a thickness of 1.5-2mm and the cavity sealed with cavit. The patients were followed up at regular intervals with radiographic evaluation at 12 weeks. At 3 months the temporary restoration was removed and dentin samples were collected from the other half of the cavity which was left in the first appointment. Atomic absorption spectrophotometry, Colorimetric test using UV-vis spectrometer and potentiometric titration were used for determining calcium, phosphorous and fluoride respectively. Results: Almost equivalent rise in the percentage of calcium level was seen in GC VII and Ca(OH)2 groups, followed by SDF group. Highest percentage rise in phosphate ions was seen in GC VII group followed by SDF group and Ca(OH)2 group. Highest percentage of fluoride rise was seen in GC VII group followed by SDF group and Ca(OH)2 group. Conclusions: The results indicated that both GC VII and SDF can be potential indirect pulp capping materials. PMID:22025824

  20. R353Q polymorphism in the factor VII gene and cardiovascular risk in Heterozygous Familial Hypercholesterolemia: a case-control study

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    Pérez-Jiménez Francisco

    2011-04-01

    Full Text Available Abstract Background Heterozygous Familial Hypercholesterolemia (FH is a genetic disorder characterized by a high risk of cardiovascular disease. Certain polymorphisms of the factor VII gene have been associated with the development of coronary artery disease and there is a known association between factor VII levels and polymorphic variants in this gene. To date, no study has evaluated the association between factor VII and coronary artery disease in patients with FH. Results This case-control study comprised 720 patients (546 with FH and 174 controls. We determined the prevalence and allele frequencies of the R353Q polymorphism of factor VII, the plasma levels of factor VII antigen (FVII Ag and whether they could be predictive factors for cardiovascular risk. 75% (410 of the patients with FH were RR, 23% (127 RQ and 1.6% (9 QQ; in the control group 75.3% (131 were RR, 21.3% (37 RQ and 3.4% (6 QQ (p = 0.32. No statistically significant associations were observed in the distribution of genotypes and allele frequencies between case (FH and control groups. Nor did we find differences when we evaluated the relationship between the R353Q polymorphism and cardiovascular risk (including coronary disease, ischemic stroke and peripheral arterial disease, either in the univariate analysis or after adjustment for sex, age, arterial hypertension, body mass index, xanthomas, diabetes, smoking, HDLc and LDLc and lipid-lowering treatment. The FVII Ag concentrations behaved in a similar fashion, with no differences for the interaction between controls and those with FH (RR vs. RQ/QQ; p = 0.96. In the subgroup of patients with FH no association was found among cardiovascular disease, genotype and FVII Ag levels (RR vs. RQ/QQ; p = 0.97. Conclusions Our study did not find a direct relationship between cardiovascular risk in patients with Heterozygous Familial Hypercholesterolemia, the R353Q polymorphism of factor VII and FVII Ag levels.