STABILIZATION OF GRANULAR VOLCANIC ASH IN SANA'A AREA

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SUBHI A. ALI

2014-02-01

Full Text Available This paper presents the findings of compaction and strength characteristics of a Granular Volcanic Ash from Sana'a city center, which was mixed with various percentages of two binders to form a stabilized material namely; fine soil and Portland cement. The study showed a significant improvement of the Volcanic Ash properties. The maximum dry density and California bearing ration (CBR were considerably increased by addition of stabilizers at different rates for different binder contents. Optimum fine soil content for the maximum dry density and CBR is determined. A relationship between the optimum moisture content and the binder combination content for different fine soil percentages was established.

Qualidade de vida de adultos com câncer colorretal com e sem ostomia Calidad de vida en adultos con cáncer colorectal con y sin ostomía Quality of life of cancer patients with and without an ostomy

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Adriana de Paula Congro Michelone

2004-12-01

Full Text Available O objetivo deste estudo foi analisar e comparar a qualidade de vida (QV dos doentes com câncer colorretal atendidos pelo SUS na XIV DIR-SP, conforme ausência e presença de estoma. Trata-se de estudo descritivo e exploratório, com abordagem quantitativa onde se utilizou a escala WHOQOL-bref para avaliação da QV. A casuística foi composta por 110 pessoas, totalizando 48 sobreviventes que compuseram dois grupos conforme ausência ou presença do estoma. Os resultados evidenciaram escores médios menores em todos os domínios para as pessoas ostomizadas, porém sem diferenças significativas na comparação com o grupo de pessoas sem ostomia. Foram constatadas diferenças estatisticamente significantes para as variáveis religião e retorno ao trabalho independente do grupo. O estudo contribuiu para o melhor delineamento acerca da QV entre pessoas operadas por câncer colorretal com e sem ostomia.La finalidad del trabajo fue analizar y comparar la calidad de vida (CV en enfermos con cáncer colorectal que reciben terapia de SUS en el XIV DIR-SP. Fue efectuado un estudio descriptivo y transversal con aproximación cuantitativa. La escala WHOQOL-bref fue utilizada para evaluar la CV. La casuística fue compuesta de 110 personas, siendo 48 supervivientes que hicieron parte de dos grupos, de acuerdo con la presencia o falta del estoma. Los resultados fueron de puntuaciones medias menores para las personas con ostomía. Todavía no ocurrieron mayores diferencias con relación con el grupo de personas sin ostomía. Fueron encontradas diferencias importantes de acuerdo con la creencia y regresión al trabajo, sin relación al grupo. El estudio ayudó en el progreso para un mejor dibujo respecto a la CV entre personas con intervención quirúrgica debido al cáncer colorectal con y sin ostomía.This study aimed to analyze and compare the quality of life of patients with colorectal cancer who were attended by the Single Health System in São Paulo. A

Etapas del modelo conductual de los estilos de vida propuestos por las guías alimentarias del Paraguay en adultos

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Macarena Morínigo Martínez

2015-04-01

Full Text Available Las etapas del modelo conductual de las personas describen el cumplimiento o no de las recomendaciones para una vida sana. Por ello, se planteó una investigación observacional descriptiva cuyo objetivo fue evaluar las etapas del modelo conductual de los estilos de vida propuestos por las Guías Alimentarias del Paraguay en adultos que residen en el barrio Salvador del Mundo de Asunción. Las variables de interés fueron las etapas de cambio, medidas a partir del modelo de Prochaska, para el consumo de sal, ingesta de bebidas alcohólicas, actividad física y manipulación de alimentos, tres de ellas están relacionadas al no cumplimiento y dos al cumplimiento de las recomendaciones. El 92,9% (91/98 de los adultos no cumple con las recomendaciones de actividad física y el 71,4% (70/98 con las recomendaciones de consumo de sal. El 46,9% (46/98 cumple con la recomendación para el consumo de bebidas alcohólicas, aunque el 74,5% (73/98 refirió su consumo. Ningún encuestado cumple con las recomendaciones de lavado y manipulación de alimentos. Es preocupante el alto porcentaje de adultos que no cumple las recomendaciones, agravado por la no intención de cambio. Por lo tanto, se puede concluir que el objetivo inicial de las guías alimentarias del Paraguay de orientar a la población sobre los estilos de vida adecuados no se cumple. Debido a esto, se debe promover la revisión del medio de implementación de las mismas para alcanzar a un sector mayor de la población, y así lograr la adopción de mejores estilos de vida.

Efecto de la práctica de actividad física y de la participación deportiva sobre el estilo de vida saludable en la adolescencia en función del género

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Isabel Castillo

2007-01-01

Full Text Available El objetivo del trabajo consiste en analizar el efecto que ejerce la actividad fisica y el deporte en el estilo de vida saludable de chicos y chicas. El estudio se realizó en una muestra representativa de adolescentes de la Comunidad Valenciana de edades comprendidas entre 11 y 15 años (N = 967. El instrumento utilizado en la presente investigación ha sido una adaptación del Inventario de Conductas de Salud en escolares (Wold, 1995 en su traducción al castellano (Balaguer, 2000, 2002. Se hipotetiza que tanto la actividad física como el deporte se relacionarán negativamente con el consumo de sustancias de riesgo para la salud (tabaco, alcohol y cannabis y con la alimentación insana, y positivamente con la alimentación sana. Los resultados informan de las implicaciones que ambas prácticas tienen en las conductas clásicas de salud que conforman el estilo de vida de los adolescentes.

Designing human centered GeoVisualization application--the SanaViz--for telehealth users: a case study.

Science.gov (United States)

Joshi, Ashish; de Araujo Novaes, Magdala; Machiavelli, Josiane; Iyengar, Sriram; Vogler, Robert; Johnson, Craig; Zhang, Jiajie; Hsu, Chiehwen E

2012-01-01

Public health data is typically organized by geospatial unit. GeoVisualization (GeoVis) allows users to see information visually on a map. Examine telehealth users' perceptions towards existing public health GeoVis applications and obtains users' feedback about features important for the design and development of Human Centered GeoVis application "the SanaViz". We employed a cross sectional study design using mixed methods approach for this pilot study. Twenty users involved with the NUTES telehealth center at Federal University of Pernambuco (UFPE), Recife, Brazil were enrolled. Open and closed ended questionnaires were used to gather data. We performed audio recording for the interviews. Information gathered included socio-demographics, prior spatial skills and perception towards use of GeoVis to evaluate telehealth services. Card sorting and sketching methods were employed. Univariate analysis was performed for the continuous and categorical variables. Qualitative analysis was performed for open ended questions. Existing Public Health GeoVis applications were difficult to use. Results found interaction features zooming, linking and brushing and representation features Google maps, tables and bar chart as most preferred GeoVis features. Early involvement of users is essential to identify features necessary to be part of the human centered GeoVis application "the SanaViz".

El tiempo en la vida humana. Disfrutar la vida.

OpenAIRE

Fernández-Crehuet, José María

2016-01-01

La conciliación de la vida profesional, familiar y personal es una tarea que estará presente durante toda nuestra vida y no siempre será sencilla. En la medida en que descubramos el sentido de nuestra vida, identificando nuestra misión, el camino que hemos de recorrer y la meta a alcanzar, podremos priorizar e integrar los distintos roles que tenemos que ejercer disfrutando del tiempo de nuestra vida.

Producción orgánica para una alimentación sana

OpenAIRE

Evangelina Méndez

2016-01-01

El presente trabajo se relaciona con la importancia del uso de fertilizantes o abonos orgánicos, como base para la producción de alimentos orgánicos, que incluye pruebas de laboratorio y la instrumentalización de encuestas a los grupos objetivos de insumos y productos orgánicos. Este artículo tiene como propósito dar a conocer los beneficios nutritivos de los productos orgánicos. El cuidado del medio ambiente y el interés por una alimentación sana han dado lugar al uso de fertilizantes orgáni...

Aplicación del taller estilos de vida sana en el maltrato infantil de los estudiantes del 5º y 6º grado de la Institución Educativa N° 30807

OpenAIRE

Huaranga Rivera, Liliana

2016-01-01

El problema de investigación de la presente investigación consiste en:¿De qué manera influye la aplicación del Taller de Estilos de Vida Sano en el maltrato infantil de los estudiantes del 5° y 6° grado de la institución educativa N° 30807? El objetivo: Comprobar la influencia de la aplicación del Taller Estilos de Vida Sano en el maltrato infantil de los estudiantes del 5° y 6° grado la Institución Educativa N° 30807. Y la hipótesis: La aplicación del Taller Estilos de Vida Sano influye sign...

Valoración física, condición física y calidad de vida en pacientes con diferentes tratamientos renales sustitutivos

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Sonsoles Hernández Sánchez

2015-06-01

Full Text Available La actividad física es de vital importancia en pacientes con enfermedad renal crónica, ya que mejora la capacidad funcional de los sujetos e incrementa notablemente su calidad de vida. Para mejorar la calidad de vida en pacientes con tratamiento renal sustitutivo, dializados o trasplantados, deberían ser incluidos programas de actividad física planificados y supervisados por profesionales. Existen varios estudios sobre entrenamiento aeróbico y de fuerza en pacientes con enfermedad renal crónica en hemodiálisis pero pocos sobre la condición física relacionada con la salud en estos pacientes y escasos los referentes a condición física en trasplantados y en pacientes con diálisis peritoneal. El objetivo principal del estudio fue evaluar el nivel de actividad física, condición física y calidad de vida de enfermos renales crónicos con diferentes tratamientos sustitutivos. Material y métodos: 25 enfermos renales crónicos varones de entre 59 y 72 años, que participaron voluntariamente en este estudio, fueron divididos en 3 grupos: trasplantados renales: N=11, hemodializados: N=6, y en tratamiento de diálisis peritoneal: N=8. Se les administró el cuestionario de cuantificación de actividad física YALE, el cuestionario de calidad de vida KDQoL y realizaron la batería de tests Senior Fitness Test (SFT. Resultados: No se encontraron diferencias significativas entre grupos en ninguno de los cuestionarios ni en los tests realizados. Los 3 grupos mostraron valores inferiores que otras poblaciones sanas de referencia de la misma edad. Conclusiones: El tipo de tratamiento sustitutivo en los pacientes con enfermedad renal crónica no influye sobre el nivel de actividad física, condición física ni calidad de vida.

Mujer Sana, Familia Fuerte: The Effects of a Culturally-Relevant, Community-Based, Promotores Program to Increase Cervical Cancer Screening among Latinas.

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McDonough, A Manuela; Vargas, Marcela; Nguyen-Rodriguez, Selena; Garcia, Melawhy; Galvez, Gino; Rios-Ellis, Britt

2016-01-01

Although cervical cancer can be prevented through screening and follow-up, Latinas' rate of Pap tests remains low due to knowledge gaps and cultural and attitudinal factors. This study used a single-group pre-/post-test design to evaluate the effectiveness of Mujer Sana, Familia Fuerte (Healthy Woman, Strong Family), an intervention intended to improve Latinas' cervical cancer prevention knowledge, attitudes, self-efficacy to obtain a Pap test, and intention to get tested. The intervention is delivered through a single session by promotores de salud, who use a culturally competent, linguistically appropriate toolkit. A total of 5,211 Latinas participated in the study. The evaluation indicated that participants had increases in knowledge, positive attitudes, self-efficacy, and intention to test. Latinas have a low rate of cervical cancer screening but a high rate of cervical cancer, and Mujer Sana, Familia Fuerte shows promise as a public health practice for use with this population.

Firma KM-SYSTÉM- uvedení zdravotní židle Ásana na český trh

OpenAIRE

Šiler, Jakub

2012-01-01

Bachelor thesis summarizes the basic methodology of market research with an emphasis on introducing a new product to the market. Special attention is paid to market research methodology, definition of target groups and selection of appropriate method of data collecting. Theoretical bases are used to design research focused on sales and communication strategy of the specific product - Ásana health chairs - for the Czech Republic. Sub-topics include issues of sedentary jobs and their influence ...

Bienestar espiritual de enfermos terminales y de personas aparentemente sanas The spiritual wellbeing of terminally ill people and the spiritual well being of apparently healthy people

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Beatriz Sánchez Herrera

2009-03-01

Full Text Available Objetivo: el objetivo principal del estudio fue describir y comparar el bienestar espiritual de personas con enfermedad terminal con el de personas aparentemente sanas. Metodología: se desarrolló con un método cuantitativo, descriptivo, comparativo. Incluyó 44 pacientes hospitalizados en la Clínica Luís Carlos Galán y 44 personas con características similares y aparentemente sanas. Para la medición del bienestar espiritual se empleó la Escala de Bienestar Espiritual de Ellison®. Resultados: el nivel general de bienestar espiritual de las personas con enfermedad terminal es alto, los niveles del componente religioso y el componente existencial del nivel de bienestar son medios. En las personas aparentemente sanas el nivel de bienestar general y por componentes es alto. Conclusión: al comparar el bienestar espiritual entre las personas con enfermedad terminal y las personas aparentemente sanas del estudio, se encontró un mayor bienestar espiritual general y del componente existencial en el grupo de las personas aparentemente sanas. No se encontró diferencia en el nivel de bienestar de la dimensión religiosa entre los grupos.Objective: The main objective of the study was to describe and compare the spiritual wellbeing of people with terminal illness with the spiritual well being of apparently healthy people. Methodology: the study was developed with a quantitative, descriptive and comparative approach. It included 44 patients hospitalized at the Luis Carlos Galan Clinic and 44 people with similar characteristics but apparently healthy. The spiritual well being was measured with the Ellison Spiritual Wellbeing Scale®. Results: the general level of spiritual well being of the people with terminal illness was high as well as its religious component. The level of the existential component of the spiritual well being in the same group was medium. In the apparently healthy people the general level of spiritual wellbeing and the level of

Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer.

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Ribeiro, Sofia Miranda de Figueiredo; Braga, Camila Bitu Moreno; Peria, Fernanda Maris; Martinez, Edson Zangiacomi; Rocha, José Joaquim Ribeiro da; Cunha, Selma Freire Carvalho

2017-01-01

To investigate the effects of oral zinc supplementation on fatigue intensity and quality of life of patients during chemotherapy for colorectal cancer. A prospective, randomized, double-blinded, placebo-controlled study was conducted with 24 patients on chemotherapy for colorectal adenocarcinoma in a tertiary care public hospital. The study patients received zinc capsules 35mg (Zinc Group, n=10) or placebo (Placebo Group, n=14) orally, twice daily (70mg/day), for 16 weeks, from the immediate postoperative period to the fourth chemotherapy cycle. Approximately 45 days after surgical resection of the tumor, all patients received a chemotherapeutic regimen. Before each of the four cycles of chemotherapy, the Functional Assessment of Chronic Illness Therapy-Fatigue scale was completed. We used a linear mixed model for longitudinal data for statistical analysis. The scores of quality of life and fatigue questionnaires were similar between the groups during the chemotherapy cycles. The Placebo Group presented worsening of quality of life and increased fatigue between the first and fourth cycles of chemotherapy, but there were no changes in the scores of quality of life or fatigue in the Zinc Group. Zinc supplementation prevented fatigue and maintained quality of life of patients with colorectal cancer on chemotherapy. Investigar os efeitos da suplementação oral de zinco sobre a intensidade da fadiga e a qualidade de vida de pacientes durante a quimioterapia para neoplasia colorretal. Estudo prospectivo, randomizado, controlado e duplo-cego conduzido em um hospital universitário público terciário, com 24 pacientes em regime quimioterápico para adenocarcinoma colorretal. Os pacientes receberam cápsulas de zinco 35mg (Grupo Zinco, n=10) ou placebo (Grupo Placebo, n=14) por via oral, duas vezes ao dia (70mg/dia), durante 16 semanas, desde o período pós-operatório imediato até o quarto ciclo de quimioterapia. Todos os pacientes receberam quimioterapia por

Iluminasi Dan Ilustrasi Naskah Jawa Di Perpustakaan Sana Pustaka Karaton Surakarta (Sebuah Kajian Kodikologis

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Sisyono Eko Widodo

2012-12-01

Full Text Available Penelitian ini bertujuan mengidentifikasi iluminasi dan ilustrasi di dalam naskah Jawa di Perpustakaan Sana Pustaka Karaton Surakarta dan mendeskripsikan bentuk­bentuknya. Data dikumpulkan dengan teknik analisis isi, fotografi, dan wawancara. Dari 700 naskah, terdapat 48 judul naskah yang mengandung iluminasi maupun ilustrasi dalam berbagai bentuk motif. Ada 15 naskah beriluminasi, 22 naskah berilustrasi, dan 11 naskah yang mengandung iluminasi dan ilustrasi. Berdasarkan fungsinya, iluminasi dapat dibedakan menjadi tiga, yaitu: iluminasi sebagai bingkai teks, iluminasi sebagai pembatas teks, dan iluminasi sebagai hiasan teks. Bentuk ilustrasi dapat diklasifikasikan ke dalam beberapa macam, yaitu duwung, kuluk, senjata, wayang, bendera, song­song, konstruksi kerangka rumah, dan kampuh. Adapun bentuk gabungan antara iluminasi dan ilustrasi berupa bentuk wayang, mahkota, senjata, dedaunan dan bunga­bungaan, bangunan rumah, serta mobil. Abstract: This research aims to identify illumination and illustration contained in the Javanese manuscripts in the Sana Pustaka Karaton Surakarta library and describe the form of them. The data collected through content analysis, photography, and interview. Among 700 manuscripts, there are 48 titles containing illumination and illustration in many forms and motifs. There are 15 manuscript illuminated, 22 manuscript illustrated, and 11 manuscript are the combination of illumination and illustration. According to the function, there are 3 classification of illuminations: 1 illumination as a text frame. 2 illumination as a text barrier, and 3 illumination as a text ornament. The form of Illustration can be classified into several types, namely duwung, kuluk, weapon, puppet, flag, song­song, construction of house structure, and kampuh. The combination form of illumination and illustration has the shape of puppet, thrown, weapon, foliage and flower, car, and house construction. Key Words: Javanese manuscript

Intestinal parasitosis among Yemeni patients with cancer, Sana'a, Yemen.

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Al-Qobati, Salah A; Al-Maktari, Mohamed T; Al-Zoa, Abdulla M Bin; Derhim, Mohamed

2012-12-01

The profile of intestinal parasitosis was assessed among patients on anticancer chemotherapy in Sana'a city, Yemen during the period from April to December 2011. A total of 206 patients (115 males & 91 females), aged 3 to 18 years with mean of 14.17 +/- 3.13 were subjected to stool examinations by different techniques. The overall rate of intestinal parasites was 63.1%. Cryptosporidium parvum was the highest (30.1%) followed by G. lamblia (18.0%) and then C. cayetanensis (5.3%). Blastocystis hominis and E. histolytica/dispar were detected in 4.9% & 2.4% respectively. E. coli, H. nana and A. lumbricoides were diagnosed in an equal of 1.5% and S. stercoralis was seen in one case only. The majority of infected patients suffered from diarrhea. They showed 4.64 risk of protozoan infections compared to those who passed formed stool with statistically significant difference. Diarrhea was associated with higher risk of cryptosporidiosis and giardiasis (OR = 2.73 & 2.67 respectively). The risk of intestinal parasitosis neither differed significantly with patients' age nor sex.

Proposal of landscape management of the Environmental Protection Area in Sana, Macaé, RJ

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Carlos André Luz Jeronymo

2012-07-01

Full Text Available The Environmental Preservation Area (EPA in Sana, Macaé, Rio de Janeiro State went through a historical process of deforestation resulting from agriculture and livestock production. Recently, this area has been occupied in unplanned ways, due to its tourist attractions and real estate speculation. A major negative impact in the region is forest fragmentation. Based on the concept of landscape management, we propose a study to identify the priority fragments to conservation and recovery in the EPA. Results of this project are essential support tools to assist the manager in the environmental planning of the EPA in its process of monitoring, inspection and management.

Dieta Mediterránea, una historia de sabor, salud y sostenibilidad

OpenAIRE

Carbajal Azcona, Ángeles

2015-01-01

Existe abundante evidencia científica del papel de la Dieta Mediterránea tradicional y de sus componentes en la Salud y la Sostenibiliad. La Dieta Mediterránea es un dieta sana, nutritiva y palatable, relacionada con la prevención de las enfermedades crónicas y con una menor morbi-mortalidad y mayor esperanza y calidad de vida. Pero no sólo es un modelo de alimentación sana para el hombre sino también para el medio ambiente. Por estar basada fundamentalmente en el consumo de alimentos de orig...

Relationship between quality of life and clinical status in patients with gastrointestinal cancer Relación entre calidad de vida y estadio clínico en pacientes con cáncer gastrointestinal

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Ricardo Sánchez

2012-12-01

Full Text Available Background: previous studies with patients having cancer have shown that quality of life scores depend on the clinical stage of the disease (the more advanced the disease, the worst quality of life. Methods: in a prospective study we studied 317 patients with gastric or colorectal cancer attending the Instituto Nacional de Cancerología between 2010 and 2011; the patients completed the EORTC QLQ-C30 before receiving treatment. This instrument measures quality of life in 15 domains. Scores of each domain were compared according to tumor stage. Differential Item Functioning was measured across neoplasm staging and tumor localization. Results: 145 patients (45.7% were diagnosed with colorectal cancer. According to clinical staging, differences in quality of life scores were observed in 4 of 15 domains (physical and social functioning, anorexia. Most of the differences in quality of life domains depended on tumor localization (patients with colorectal cancer had the highest scores in quality of life and sex (women reported better scores. These differences seemed to be independent of item properties. The construct was more adequately measured with items that explore the construct using a general approach. Conclusion: in this group of patients with colorectal and gastric cancer quality of life scores were more related with tumor localization than with clinical stage.Introducción: la calidad de vida de pacientes con cáncer varía según el estadio clínico de la enfermedad, siendo peor en estadios avanzados. Métodos: estudio prospectivo en el que se evaluaron 317 pacientes con cáncer colorrectal o gástrico que asistieron al Instituto Nacional de Cancerología durante los años 2010 y 2011 y que no habían iniciado tratamiento. Se utilizó el cuestionario EORTC QLQ C-30, un instrumento que mide calidad de vida en 15 dominios. Se compararon las puntuaciones para cada dominio según el estadio tumoral. Adicionalmente se realizó un análisis de

Higher Education in the Republic of Yemen: The University of Sana'a. Policy, Research, and External Affairs Working Papers Series. Education and Employment.

Science.gov (United States)

Selvaratnam, Viswanathan; Regel, Omporn L.

This analytical report reviews higher education in Yemen, specifically at Yemen's national university, the University of Sana'a. It finds that university enrollment has been increasing very rapidly from 17,000 students in 1987 to a projected enrollment of 79,000 students by 2000. This explosive growth has resulted in overcrowded classrooms,…

Cruce de miradas sobre Lepa Vida (Hermosa Vida

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Barbara Pregelj

2015-04-01

Full Text Available Los eslovenos tenemos varios héroes míticos marcados por la experiencia de la interculturalidad: el buen soberano Kralj Matjaž (el Rey Matías que duerme bajo el monte de Peca, esperando a que le crezca lo suficientemente la barba para poder entrar en acción; Martin Krpan, hombre fuerte como un roble que liberó Viena del mal y a cambio consiguió un permiso especial para traficar con sal; Peter Klepec, un chico humilde que compartía con los demás su fuerza; y Lepa Vida (Hermosa Vida, la joven madre que por engaño abandona a su hijo y su hogar para viajar en barco al extranjero. Todos ellos tienen origen en el bagaje cultural popular y todos ellos posteriormente han sido objeto de nuevas y distintas adaptaciones artísticas. Entre las adaptaciones literarias por frecuencia sobresale Hermosa Vida, que a su vez ha tenido eco (aunque mucho menor en la pintura: sobresale la obra de Maksim Gaspari, y la obra de Marko Kociper (2010 en cómic ‒recogida en una de las versiones literarias más recientes, Hermosa Vida en acción de Andrej Rozman Roza.

Qualidade de vida do paciente com câncer colorretal em quimioterapia ambulatorial Calidad de vida de los pacientes con cáncer colorrectal en quimioterapia ambulatoria Quality of life of patients with colorectal cancer receiving outpatient chemotherapy

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Patrícia Lemos Chaves

2011-12-01

Full Text Available Trata-se de um estudo transversal com abordagem quantitativa descritiva, no qual buscou-se avaliar a qualidade de vida (QV do paciente com câncer colorretal em quimioterapia ambulatorial. A pesquisa foi desenvolvida em uma Unidade de Quimioterapia Ambulatorial em um hospital do sul do Brasil, cujos pacientes eram portadores do diagnóstico de câncer colorretal e foram submetidos ao tratamento com o Protocolo 5FU. A amostra contou com 48 participantes que estavam em tratamento quimioterápico por um período de seis meses. Utilizou-se como instrumento um questionário, o WHOQOL-Bref. Nos resultados encontrados, prevaleceu a idade de 50 anos ou mais e possuíam no mínimo um mês e no máximo 11 meses de tratamento. Os domínios do WHOQOL-Bref afetados mais significativamente foram o psicológico e o das relações sociais, respectivamente, havendo diferença nas respostas quanto à QV geral naqueles que estavam no 1º ciclo de tratamento daqueles que já se encontravam no 6º ciclo.Este es un estudio transversal con un enfoque cuantitativo descriptivo, que buscó evaluar la calidad de vida (QOL de los pacientes con cáncer colorrectal en quimioterapia ambulatorial. La investigación fue desarrollada en una unidad de quimioterapia Outpatient Clinic en un hospital del sur de Brasil, cuyos pacientes tenían el diagnóstico de cáncer colorrectal y que se presentaron al tratamiento con el Protocolo 5FU. La muestra ha contado con 48 participantes que se encontraban en quimioterapia por un período de 6 meses. Se utilizó como instrumento un cuestionario, WHOQOL-Bref. En los resultados, prevaleció la edad de 50 años o más y tenían al menos un mes y un máximo de 11 meses de tratamiento. Las áreas de WHOQOL-Bref afectadas más significativamente eran las esferas psicológica y las relaciones sociales, respectivamente, con diferencia en las respuestas de QOL general las que estaban en 1 ciclo de aquellos que ya estaban en el ciclo 6TH.This is a

Patient satisfaction and loyalty to the private hospitals in Sana'a, Yemen.

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Anbori, Ali; Ghani, Sirajoon Noor; Yadav, Hematram; Daher, Aqil Mohammad; Su, Tin Tin

2010-08-01

To evaluate patients' satisfaction and loyalty to private hospitals and to identify factors influencing patient loyalty. A cross-sectional, population-based study was conducted between May and September of 2005. Sana'a, the capital city of the Republic of Yemen. Eight hundred and nineteen respondents who were admitted for at least 1 day in a private hospital within last 6 months from the date of interview. The scores on the modified SERVQUAL market research instrument including six domains (tangibility, reliability, responsiveness, assurance, empathy and cost) that identify perceptions of service quality. In addition, the respondents were asked whether or not they would return to the same facility when they need future medical care (loyalty). Loyalty was higher among females [odds ratio (OR) = 1.44; P loyalty and, tangibility and responsiveness score. Improvements are required to achieve high-quality healthcare services in the private hospitals in Yemen and increase loyalty among patients. Findings from this study could inform private sector healthcare development in low- and middle-income countries.

Natural radioactivity in the volcanic field north of Sana'a, Yemen

International Nuclear Information System (INIS)

Saleh, E.E.; El-Mageed, A.I.; EI-Kamel, A.H.; Abbady, A.; Harb, S.

2011-01-01

The level of natural radioactivity in rocks and soil of 32 samples collected from locations at North Sana'a in Yemen was measured. Concentrations of radionuclides in rocks and soils samples were determined by gamma-ray spectrometer using HPGe detector with specially designed shield. The average radioactivity concentrations of 226 Ra, 232 Th and 40 K were determined and expressed in Bq kg -1 . The results showed that these radionuclides were present in concentrations of 21.79 ± 3.1, 19.5 ± 2.6 and 399.3 ± 16 Bq kg -1 , respectively, for rocks. For soil, the corresponding values were 48.2 ± 4.4, 41.7 ± 4.5 and 939.1 ± 36 Bq kg -1 . Also, the radiological hazard of the natural radionuclides content, radium equivalent activity, total dose rates, external hazard index and gamma activity concentration index of the (rocks/soils) samples in the area under consideration were calculated. The data were discussed and compared with those given in the literature. (author)

Colorectal Cancer Screening

Science.gov (United States)

... Genetics of Colorectal Cancer Colorectal Cancer Screening Research Colorectal Cancer Screening (PDQ®)–Patient Version What is screening? Go ... These are called diagnostic tests . General Information About Colorectal Cancer Key Points Colorectal cancer is a disease in ...

Colorectal Cancer Prevention

Science.gov (United States)

... Genetics of Colorectal Cancer Colorectal Cancer Screening Research Colorectal Cancer Prevention (PDQ®)–Patient Version What is prevention? Go ... to keep cancer from starting. General Information About Colorectal Cancer Key Points Colorectal cancer is a disease in ...

O direito à vida

Directory of Open Access Journals (Sweden)

Luciana Mendes Pereira Roberto

2004-12-01

Full Text Available The Life is the basic property of the human being, because without the life, there is no way to talk about other rights, not even about the personality ones. According to this understanding, each single man has the right to the life, ie, the right to live, and not even it, he also has the right to a full and a dignified life, respect to their values and requirements. In this study, the start of the life to the Right is showed, as well its ending, with the death. Also, it is tried to elucidate the life as a primordial right of the personality, and the sanctions of even transgression.A Vida é o bem fundamental do ser humano, pois sem a vida, não há que se falar em outros direitos, nem mesmo os de personalidade. Com base nesse entendimento, todo o homem tem direito à vida, ou seja, o direito de viver e não apenas isso, tem o direito de uma vida plena e digna, respeito aos seus valores e necessidades. Procura-se, neste estudo, mostrar o início da vida para o Direito, bem como o seu fim, com a morte. Busca-se também elucidar a vida como direito primordial da personalidade, e as sanções de tal transgressão.

Perceptions of ostomized persons due to colorectal cancer on their quality of life

Directory of Open Access Journals (Sweden)

Cristilene Akiko Kimura

2017-01-01

Full Text Available Introduction: The significance of the change in the physical body and suffering as the new condition of life of stoma oncological person affect the physical, psychological, social relationships and environment. Objective: To know the perception of quality of life and the interpretation of the biopsychosocial reality of intestinal ostomy due to colorectal cancer clinics of the Ambulatory Care Program ostomy patients of the Health Secretariat of the Federal District, Brazil. Methods: Epidemiological based study, analytical character, with cross-sectional descriptive design with quantitative and qualitative approach in the light of the content analysis. Sample consisted of convenience, included 120 participants. They used the questionnaires sociodemographic, clinical, and WHOQOL-BREF and an individual interview. Data were analyzed by Microsoft Office Excel 2010 and SPSS 20.0 software. Statistical significance was accepted at 5%. Results: Physical Domains, Social Affairs and Environment are correlated with the mean score, statistically significant (p < 0.0001, the content analysis resulted in four categories: Wellness Physical, Psychological Wellness, Wellness and Spiritual Well living Social. Conclusion: Ostomy and colorectal cancer may represent suffered mutilation, loss of productive capacity resulting in the loss of quality of life. Resumo: Introdução: O significado da alteração no corpo físico e o sofrimento quanto à nova condição de vida da pessoa oncológica estomizada afetam os aspectos físico, psicológico, relações sociais e meio ambiente. Objetivo: Conhecer a percepção da qualidade de vida e a interpretação da realidade biopsicossocial de estomizados intestinais em razão do câncer colorretal dos ambulatórios do Programa de Assistência Ambulatorial do Estomizado da Secretaria de Saúde do Distrito Federal, Brasil. Métodos: Estudo de base epidemiológica, de caráter analítico, com delineamento transversal e

La bailoterapia, una opción saludable y divertida para elevar la calidad de vida de las personas de cualquier edad

Directory of Open Access Journals (Sweden)

Belkys Lázara Balmaseda Albelay

2010-06-01

Full Text Available El presente artículo está encaminado a promover la práctica de la bailoterapia en todos los grupos etáreos de la población cubana. Por ello nos proponemos divulgar los beneficios que aporta la misma para elevar la calidad de vida de las personas, demostrando lo saludable que es realizarla y la forma de elevar la autoestima de quienes la practican con el fin de dar un uso mas útil y saludable al tiempo libre. Pensamos que hay una forma deportiva que podrá ser profundamente comunitaria y a la vez necesaria, y es el deporte realizado en grupo que tiene como objetivo no ganar una competencia sino lograr una forma física mínima, un estado de movilidad adecuado y un estado de animo elevado. La bailoterapia que se realiza con música, que aporta movilidad y estado de animo adecuado al organismo, es la base de este artículo, constituyendo una actividad deportiva recreativa para todas aquellas personas que deseen realizar ejercicios físicos con el fin de mantener un cuerpo sano, una mente sana y no con un fin deportivo.

Prevalence of oro-dental anomalies among schoolchildren in Sana'a city, Yemen.

Science.gov (United States)

Basalamah, M; Baroudi, K

2016-04-19

Practitioners and policy-makers need information about the relative frequency of dental anomalies among children in their region. This study investigated the prevalence of different oral anomalies among schoolchildren in Sana'a city, Yemen. A sample of 1000 private and public schoolchildren aged 4-12 years were examined by the same examiner using disposable tongue blades. The total prevalence of oral anomalies was 15.1%, most commonly in boys (male:female ratio 3.2:1) aged 7-12 years. The most prevalent dental anomaly related to hard tissues was tooth hypoplasia (2.8%), followed by hypocalcification (2.6%), then microdontia (0.5%), macrodontia (0.4%), hypodontia (0.4%), supernumerary teeth (0.3%), tooth transposition (0.3%), dental fusion (0.2%) and gemination (0.2%). The most prevalent soft tissues anomaly was fissured tongue (4.0%), followed by ankyloglossia (1.8%), geographic tongue (0.9%), macroglossia (0.4%) and hairy tongue (0.3%). Appropriate measures need to be taken early to mitigate the negative impact and later costs of treatment of anomalies.

Hablar del sentido de la vida

OpenAIRE

Jean Grondin

2012-01-01

La pregunta por la vida, es un preguntar por y desde el sentido de lo que es y porta la vida. Interesa destacar la pregunta socrática o filosófica por el "sentido de la vida", en términos de existencia y realidad. La existencia del sentido la porta la vida; sin embargo, la dirección, la reflexión, la significación y, sobre todo, el sentir el sentido, es la tarea humana que le toca realizar a quien se pregunta por el thelos de la vida, su fin o finalidad. La naturaleza del mundo es lingüística...

Comparing dementia caregivers and healthy controls in mental health and health related quality of life in Cali, Colombia

Directory of Open Access Journals (Sweden)

Brenna Posner

2015-01-01

Full Text Available A pesar de que los cuidadores de personas con demencia están en riesgo de sufrir estrés, depresión y múltiples consecuencias negativas para la salud, en América Latina se han realizado pocos estudios que hayan investigado el alcance de estos problemas. El propósito de este estudio fue comparar la salud mental y la calidad de vida relacionada con la salud (CVRS de un grupo de cuidadores de personas con demencia con un grupo de personas sanas de Cali (Colombia. Noventa cuidadores de personas con demencia y 51 personas sanas completaron una serie de cuestionarios que medía depresión, satisfacción con la vida, estrés y CVRS. A pesar de que se planteó la hipótesis de que los cuidadores de personas con demencia obtendrían niveles más bajos de salud mental y CVRS en comparación con el grupo de personas sanas, los cuidadores sólo reportaron mayores índices de depresión. Estos resultados sugieren que los cuidadores de demencia de esta región, a pesar tener acceso a los servicios de salud, necesitan servicios de salud mental y otros recursos de cuidado. Este tipo de ayudas e intervenciones probablemente ayudarían a mejorar su salud mental y la calidad de cuidado que pueden ofrecer a las personas que sufren demencia.

Identificación de especies de Malassezia aisladas de piel sana en pobladores de Lima, Perú

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Vilma Bejar

2014-04-01

Full Text Available Objetivo: Identificar las especies de Malassezia en zonas seborreicas de piel sana en población limeña. Diseño: Estudio descriptivo transversal. Lugar: Instituto de Medicina Tropical ‘Daniel Alcides Carrión’, Universidad Nacional Mayor de San Marcos, Lima, Perú. Participantes: Pobladores asintomáticos. Intervenciones: Empleando la técnica de Mariat y Adan-Campos, se recolectó muestras de piel de 129 pobladores asintomáticos de diversos distritos de la ciudad de Lima. El aislamiento de Malassezia se realizó en medio Dixon modificado e incubado a 32ºC por 7 días, la identificación de las colonias por sus características macro y micromorfológicas, y la tipificación mediante el estudio de las propiedades bioquímicas y fisiológicas según la técnica de Guillot y col. Principales medidas de resultados: Especie de Malassezia, sexo, edad y región anatómica. Resultados: Se aisló Malassezia spp en 43,4% de los pobladores, obteniéndose 49,2% en varones y 37,5% en mujeres. De las diferentes regiones corporales, 68 cultivos fueron positivos: cuero cabelludo 31 (45,6%, espalda 36 (52,9% y región frontal 1 (1,5%. El grupo etario con mayor frecuencia de aislamientos (47,2% fue el de 14 a 25 años (adolescentes jóvenes. M. slooffiae fue encontrado en 83,8% y M. obtusa en 16,2% de los casos. Conclusiones: Se encontró Malassezia spp. en la piel humana sana. M. slooffiae fue la especie predominante de los casos positivos (83,8% seguido de M. obtusa (16,2%.

Avaliação da qualidade de vida e toxicidades em pacientes com câncer colorretal tratados com quimioterapia adjuvante baseada em fluoropirimidinas Evaluation of the toxicity and quality of life in patients with colorectal cancer treated with chemotherapy

Directory of Open Access Journals (Sweden)

Vanessa Maria Nunes Roque

2006-06-01

� qualidade de vida foram observadas alterações significantes nos domínios físico e psicológico quando comparadas a primeira com a segunda ou a primeira com a terceira aplicação do questionário. Não foi encontrada alteração da qualidade de vida entre os doentes em quimioterapia adjuvante quando comparada aos em tratamento paliativo. Independente da indicação terapêutica, a média dos escores de qualidade de vida diminuiu em relação aos domínios físico e social na terceira aplicação do teste. CONCLUSÃO: As toxicidades gastrointestinais foram mais freqüentes que as hematológicas com o esquema utilizado. A qualidade de vida diminuiu após o início da quimioterapia em relação à atividade física e psicológica. No estudo da média dos escores observou-se queda dos mesmos nos domínios físico e social. A análise do questionário não mostrou alteração de qualidade vida quando comparados os doentes em tratamento paliativo com os em adjuvância.BACKGROUND: The colorectal cancer is the fourth cause of cancer in Brazil and 5-fluorouracil is the drug most commonly used in the adjuvant or palliative treatment of this disease. AIM - Evaluating in patients with colorectal cancer and chemotherapy, the toxicity and the quality of life. PATIENTS AND METHODS: From March 2001 and May 2003, 45 patients treated with colorectal cancer treated with 5-fluourouracil and folinic acid were followed closely during six cycles. The gastrointestinal and hematologic toxicity was analysed making use of the chart "Recommendations for the Graduation of Acute and Subacute Toxicity". After the end of each cycle of chemotherapy, the results were registered according to the respectives degrees that vary from 0 to 4. The quality of life was researched through the WHOQOL bref (World Health Organization Quality of Life questionary that consists of 26 questions and 4 domains: physical, psychological, social relations and environmental, in the beginning, on the 3rd and 6th cycles of

Valores referenciales de plombemia en el área de Buenos Aires.: Población adulta sana no expuesta laboralmente

OpenAIRE

Clara Magdalena, López; Adriana Emilce, Piñeiro; Valeria, Pongelli; Villaamil Lepori, Edda Cristina; Roses, Otmaro Enrique

2005-01-01

Los niveles de plomo en sangre fueron determinados en una población adulta sana y no expuesta laboralmente al metal, habitantes de la Ciudad Autónoma de Buenos Aires y del Gran Buenos Aires. Las muestras de sangre venosa provenientes de sujetos de ambos sexos (n = 278) fueron procesadas por absorción atómica-atomización electrotérmica a 283,3 nm. Los valores de plombemia obtenidos para la población total fueron de 2,27 a 17,35 µg/dL. La población femenina estudiada (n = 123) tuvo valores comp...

Quality of Life Analysis in Ostomized Colorectal Cancer Patients

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Cristilene Akiko Kimura

2013-10-01

Full Text Available Introduction: the oncological patient submitted to ostomy faces multiple losses which affect their quality of life.Objective: assess quality of life in ostomized patients due to colorectal cancer, regarding the physical, psychological, social and environmental relationships, treated at the Ostomy Program of the Health Department of Distrito Federal, Brazil.Methods: epidemiological-based, analytical, cross-sectional and descriptive study. The sample consisted of 54 patients enrolled in the Ostomy Program of the Health Department of Distrito Federal - Brazil. The WHOQOL-BREF questionnaire was used to evaluate quality of life. Data was analyzed by Microsoft ® Office Excel 2010 and SPSS 20.0.Results: the Physical, Social and Environmental aspects were correlated to the mean score, resulting in statistical significance (p<0.0001. The item “Positive feelings” in the Psychological Domain was the only one that did not achieve statistical significance.Conclusion: the results demonstrate that the care of cancer patients with ostomies should focus on the technical-scientific, political and socio-educational actions, to allow a multidisciplinary team to recognize health as a right for all, working to guarantee the health care process. Resumo: Introdução: a pessoa estomizada oncológica, depara-se com o enfrentamento de várias per- das, comprometendo sua qualidade de vida.Objetivo: analisar a qualidade de vida de pacientes estomizados por câncer colorretal, sob as dimensões física, psicológica, de relações sociais e do meio ambiente, atendidos pelo Programa de Estomizados da Secretaria de Saúde do Distrito Federal, Brasil.Métodos: estudo de base epidemiológica, de caráter analítico, com delineamento transversal e descritivo. Amostra constituída por 54 pacientes cadastrados no Programa de Estomiza- dos da Secretaria de Saúde do Distrito Federal – Brasil. Utilizou-se o questionário WHOQOL-bref para avaliar a qualidade de vida. Os dados

Metachronous colorectal carcinoma

DEFF Research Database (Denmark)

Bülow, Steffen; Svendsen, L B; Mellemgaard, A

1990-01-01

During the period 1943-67, 903 Danish patients aged less than 40 years had colorectal carcinoma. The patients were followed up for up to 41 years and during this period 44 of 501 (9 per cent) operated on for cure developed a metachronous colorectal carcinoma. The cumulative risk of a metachronous...... colorectal carcinoma was 30 per cent after up to 41 years of observation. The occurrence of a metachronous colorectal carcinoma was evenly distributed in the observation period. The cumulative survival rate after operation for a metachronous colorectal carcinoma was 41 per cent after 20 years of observation....... We propose a lifelong follow-up programme after resection of colorectal carcinoma for cure in this age group, including annual Hemoccult test and colonoscopy at 3-year intervals....

Embodied Medicine: Mens Sana in Corpore Virtuale Sano.

Science.gov (United States)

Riva, Giuseppe; Serino, Silvia; Di Lernia, Daniele; Pavone, Enea Francesco; Dakanalis, Antonios

2017-01-01

Progress in medical science and technology drastically improved physicians' ability to interact with patient's physical body. Nevertheless, medicine still addresses the human body from a Hippocratic point of view, considering the organism and its processes just as a matter of mechanics and fluids. However, the interaction between the cognitive neuroscience of bodily self-consciousness (BSC), fundamentally rooted in the integration of multisensory bodily inputs, with virtual reality (VR), haptic technologies and robotics is giving a new meaning to the classic Juvenal's latin dictum " Mens sana in corpore sano " (a healthy mind in a healthy body). This vision provides the basis for a new research field, "Embodied Medicine": the use of advanced technologies for altering the experience of being in a body with the goal of improving health and well-being. Up to now, most of the research efforts in the field have been focused upon how external bodily information is processed and integrated. Despite the important results, we believe that existing bodily illusions still need to be improved to enhance their capability to effectively correct pathological dysfunctions. First, they do not follow the suggestions provided by the free-energy and predictive coding approaches. More, they lacked to consider a peculiar feature of the human body, the multisensory integration of internal inputs (interoceptive, proprioceptive and vestibular) that constitute our inner body dimension. So, a future challenge is the integration of simulation/stimulation technologies also able to measure and modulate this internal/inner experience of the body. Finally, we also proposed the concept of "Sonoception" as an extension of this approach. The core idea is to exploit recent technological advances in the acoustic field to use sound and vibrations to modify the internal/inner body experience.

Colorectal polyps

Science.gov (United States)

Intestinal polyps; Polyps - colorectal; Adenomatous polyps; Hyperplastic polyps; Villous adenomas; Serrated polyp; Serrated adenoma; Precancerous polyps; Colon cancer - polyps; Bleeding - colorectal polyps

The Effect of Using a Program Based on Cooperative Learning Strategy on Developing some Oral Communication Skills of Students, at English Department, Faculty of Education, Sana'a University

Science.gov (United States)

Zuheer, Khaled Mohsen Mohammed

2008-01-01

The purpose of study is to investigate the effective of using a cooperative learning strategy STAD-based program on developing some oral communication skills of second level students, English Department, Faculty of Education, Sana'a University. Based on literature review, related studies and a panel of jury members' point of view, a list of 5 oral…

Risks of Colorectal Cancer Screening

Science.gov (United States)

... Genetics of Colorectal Cancer Colorectal Cancer Screening Research Colorectal Cancer Screening (PDQ®)–Patient Version What is screening? Go ... These are called diagnostic tests . General Information About Colorectal Cancer Key Points Colorectal cancer is a disease in ...

Una alternativa de diseño y confección de medios auxiliares para el desarrollo de actividades Físico-Recreativas en niños entre 8 y 10 años de la Zona #173 del Consejo Popular Hermanos Cruz del municipio Pinar del Río

Directory of Open Access Journals (Sweden)

Abel Castillo López

2010-09-01

Full Text Available La práctica de las actividades físicas-recreativas es tan antigua como el hombre mismo; en nuestros días se le concede vital importancia pues compensan la carga física, intelectual y emocional para evitar desequilibrios en su comportamiento personal y social, mediante la recreación de forma sana y constructiva en sus dimensiones como disciplina y como política de Estado. Hoy en día la intervención comunitaria a través de estas actividades se ha convertido en una necesidad, pues el desarrollo comunitario en gran medida implica un desarrollo social. Es por este sentido que se hace necesaria una alternativa para gestionar aditamentos e implementos deportivos auxiliares que contribuyan al incremento de las actividades físico-recreativas en la comunidad para niños entre 8/10 años, de una manera sana, propiciando estilos de vida saludables, capaces de manifestar en todos los aspectos un mejoramiento de la calidad de vida y provocando cambios en los hábitos, cultura en los niños, atendiendo a sus gustos y preferencias.

[Aspirin and colorectal cancer].

Science.gov (United States)

Grancher, Adrien; Michel, Pierre; Di Fiore, Frédéric; Sefrioui, David

2018-02-01

Colorectal cancer is a worldwide public health problem. Aspirin has been identified as a protective factor against the apparition of colorectal cancer. There are several mechanisms about the actions by aspirin on colorectal tumorogenesis. These are not perfectly known nowadays. On one hand, there are direct mechanisms on colorectal mucosa, on the other hand there are indirect mechanisms through platelet functions. Aspirin also plays a role by its anti-inflammatory action and the stimulation of antitumor immunity. Several studies show that long-term treatment with low-doses of aspirin decreases the incidence of adenomas and colorectal cancers. In the United States, aspirin is currently recommended for primary prevention of the risk of colorectal cancer in all patients aged 50 to 59, with a 10-year risk of cardiovascular event greater than 10 %. However, primary prevention with aspirin should not be a substitute for screening in colorectal cancer. Furthermore, aspirin seems to be beneficial when used in post-diagnosis of colorectal cancer. It could actually decrease the risk of metastasis in case of a localized colorectal cancer, and increase the survival in particular, concerning PIK3CA mutated tumors. The association of aspirin with neoadjuvant treatment of colorectal cancer by radiochimiotherapy seems to have beneficial effects. French prospective randomized study is currently being conducted to investigate postoperative aspirin in colorectal cancers with a PIK3CA mutation. Copyright © 2017 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

Sugars, sucrose and colorectal cancer risk: the Fukuoka colorectal cancer study.

Science.gov (United States)

Wang, Zhenjie; Uchida, Kazuhiro; Ohnaka, Keizo; Morita, Makiko; Toyomura, Kengo; Kono, Suminori; Ueki, Takashi; Tanaka, Masao; Kakeji, Yoshihiro; Maehara, Yoshihiko; Okamura, Takeshi; Ikejiri, Koji; Futami, Kitaroh; Maekawa, Takafumi; Yasunami, Yohichi; Takenaka, Kenji; Ichimiya, Hitoshi; Terasaka, Reiji

2014-05-01

A diet high in sugars may promote colorectal carcinogenesis, but it remains uncertain whether high intake of sugars or sucrose confers increased risk of colorectal cancer. The authors investigated the associations of sugars and sucrose intake with colorectal cancer risk in a community-based case-control study in Japan. The study subjects comprised 816 incident cases of colorectal cancer and 815 community controls. Consumption frequencies and portion sizes of 148 food and beverage items were ascertained by a computer-assisted interview. The authors used the consumption of 29 food items to estimate sugars and sucrose intake. The odds ratios of colorectal cancer risk according to intake categories were obtained using a logistic regression model with adjustment for potential confounding variables. Overall, intakes of sugars and sucrose were not related to colorectal cancer risk either in men or women. The association between sugars intake and colorectal cancer risk differed by smoking status and alcohol use in men, but not in women. In men, sugars intake tended to be associated with colorectal cancer risk inversely among never-smokers and positively among male ever-smokers (interaction p=0.01). Sugars intake was associated with an increased risk among men with no alcohol consumption, but was unrelated to the risk among male alcohol drinkers (interaction p=0.02). Body mass index did not modify the association with sugars intake in either men or women. Sugars intake was associated with increased risk of colorectal cancer among smokers and non-alcohol drinkers in men selectively.

Epigenetics and Colorectal Cancer

Science.gov (United States)

Lao, Victoria Valinluck; Grady, William M.

2012-01-01

Colorectal cancer is a leading cause of cancer deaths in the world. It results from an accumulation of genetic and epigenetic changes in colon epithelial cells that transforms them into adenocarcinomas. There have been major advances in our understanding of cancer epigenetics over the last decade, particularly regarding aberrant DNA methylation. Assessment of the colon cancer epigenome has revealed that virtually all colorectal cancers have aberrantly methylated genes and the average colorectal cancer methylome has hundreds to thousands of abnormally methylated genes. As with gene mutations in the cancer genome, a subset of these methylated genes, called driver genes, is presumed to play a functional role in colorectal cancer. The assessment of methylated genes in colorectal cancers has also revealed a unique molecular subgroup of colorectal cancers called CpG Island Methylator Phenotype (CIMP) cancers; these tumors have a particularly high frequency of methylated genes. The advances in our understanding of aberrant methylation in colorectal cancer has led to epigenetic alterations being developed as clinical biomarkers for diagnostic, prognostic, and therapeutic applications. Progress in the assessment of epigenetic alterations in colorectal cancer and their clinical applications has shown that these alterations will be commonly used in the near future as molecular markers to direct the prevention and treatment of colorectal cancer. PMID:22009203

Colorectal Cancer

Science.gov (United States)

... rectum are part of the large intestine. Colorectal cancer occurs when tumors form in the lining of ... men and women. The risk of developing colorectal cancer rises after age 50. You're also more ...

The Association Between Molecular Markers in Colorectal Sessile Serrated Polyps and Colorectal Cancer Risk

Science.gov (United States)

2017-08-01

AWARD NUMBER: W81XWH-15-1-0273 TITLE: The Association between Molecular Markers in Colorectal Sessile Serrated Polyps and Colorectal Cancer ... Colorectal Cancer Risk 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-15-1-0273 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Andrea Burnett-Hartman 5d... cancer in patients with sessile serrated colorectal polyps (SSPs). The project’s specific aims are as follows: 1) Estimate the risk of colorectal

Colorectal tuberculosis

International Nuclear Information System (INIS)

Nagi, B.; Kochhar, R.; Bhasin, D.K.; Singh, K.

2003-01-01

Our objective was to evaluate the incidence of colorectal tuberculosis in our series and to study its radiological spectrum. A total of 684 cases of proven gastrointestinal tuberculosis with positive barium contrast findings seen over a period of more than one decade were evaluated. The study did not include cases where colon was involved in direct contiguity with ileo-caecal tuberculosis. Seventy-four patients (10.8%) had colorectal tuberculosis. Commonest site involved was transverse colon, closely followed by rectum and ascending colon. Radiological findings observed were in the form of strictures (54%), colitis (39%) and polypoid lesions (7%). Complications noted were in the form of perforations and fistulae in 18.9% of cases. Colorectal tuberculosis is a very common site for gastrointestinal tuberculosis. Typical findings of colorectal tuberculosis are strictures, signs of colitis and polypoid lesions. Common complications are perforation and fistulae. (orig.)

con mala calidad de vida

Directory of Open Access Journals (Sweden)

Agustín Martín-Rodríguez

2007-01-01

Full Text Available En este estudio ex post facto se ha analizado si los familiares de pacientes con mala calidad de vida presentan diferencias en las variables clínicas de personalidad y relaciones familiares en función de que el paciente haya estado o no ingresado en una Unidad de Cuidados Intensivos. Seleccionamos dos grupos: 29 familiares de pacientes traumatizados graves transcurridos cuatro años de su ingreso en una UCI de Traumatología y con mala calidad de vida (debido a secuelas físicas y/o psicológicas tras el ingreso, tales como traumatismos craneoencefálicos, politraumatismos y tetraplejias traumáticas y 32 familiares de pacientes con mala calidad de vida con cuatro años de evolución de su enfermedad física (hipertensión, diabetes, artritis reumatoide y síndrome de intestino irritable que no han estado ingresados en la UCI. Para alcanzar nuestro objetivo empleamos una Encuesta Psicosocial y los siguientes instrumentos: Cuestionario de Análisis Clínico, Escala de Clima Social en la Familia y Escala de Adaptación Psicosocial de la Enfermedad. Los resultados mostraron que los familiares de pacientes con mala calidad de vida que estuvieron ingresados en la UCI hace cuatro años, presentan diferencias significativas en las variables agitación y expresividad comparados con los familiares de pacientes con mala calidad de vida que no han estado ingresados en la UCI.

La vida y la flecha del tiempo

Directory of Open Access Journals (Sweden)

Jaksel Nájera Mota

2014-01-01

Full Text Available La vida y la flecha del tiempo se fundamentan en una interrelación entre orden-desorden, muerte-vida, acumulación-pérdida que permite transformaciones y disipaciones en la estructura orgánica. Por lo anterior, se analizan algunos procesos metabólicos y de regeneración celular. Se demuestra que a pesar de los esfuerzos por retrasar el desgaste del organismo, la vida se mantiene dirigida a la degradación; sin embargo, es posible minimizar algunos problemas causados por el envejecimiento manteniendo una vida más saludable, con ejercicio y buena alimentación.

Get Tested for Colorectal Cancer

Science.gov (United States)

... Print This Topic En español Get Tested for Colorectal Cancer Browse Sections The Basics Overview What to Expect ... section Overview 2 of 6 sections The Basics: Colorectal Cancer What is colorectal cancer? Colorectal cancer is a ...

A vida do bebê: a constituição de infâncias saudáveis e normais nos manuais de puericultura brasileiros

Directory of Open Access Journals (Sweden)

Cláudia Amaral dos Santos

2011-01-01

Full Text Available Este trabajo tiene por objetivo investigar como el libro A vida do bebê, escrito por el pediatra brasileño Rinaldo De Lamare, fomenta/fomentó biopolíticas dirigidas a las madres hacia la constitución de infancias sanas y normales. Se enfatiza el valor que el manual analisado ejerce/ejerció como función pedagógica, enseñando madres y padres a como actuar hacia sus hijas/hijos, produciendo de ese modo subjetividades, identidades y saberes. A la realización del análisis, fueron utilizados como referencial teórico los Estudios Culturales a partir de una mirada postestructuralista y los escritos de Michel Foucault. Como material de análisis fueron utilizadas dos ediciones del manual. La primera, la 17ª edición (de 1963; y la segunda, la 41ª edición (de 2002. A partir del análisis se verificó la fuerza del discurso de la psicología como forma de subjetivar las madres y la visión evolutiva del desarrollo del niño normal en la publicación que ahora se hace objeto de este estudio.

[Obesity and colorectal cancer].

Science.gov (United States)

Na, Soo-Young; Myung, Seung-Jae

2012-01-01

Obesity worldwide is constantly increasing. Obesity acts as an independent significant risk factor for malignant tumors of various organs including colorectal cancer. Visceral adipose tissue is physiologically more important than subcutaneous adipose tissue. The relative risk of colorectal cancer of obese patients is about 1.5 times higher than the normal-weight individuals, and obesity is also associated with premalignant colorectal adenoma. The colorectal cancer incidence of obese patients has gender-specific and site-specific characteristics that it is higher in men than women and in the colon than rectum. Obesity acts as a risk factor of colorectal carcinogenesis by several mechanisms. Isulin, insulin-like growth factor, leptin, adiponectin, microbiome, and cytokines of chronic inflammation etc. have been understood as its potential mechanisms. In addition, obesity in patients with colorectal cancer negatively affects the disease progression and response of chemotherapy. Although the evidence is not clear yet, there are some reports that weight loss as well as life-modification such as dietary change and physical activity can reduce the risk of colorectal cancer. It is very important knowledge in the point that obesity is a potentially modifiable risk factor that can alter the incidence and outcome of the colorectal cancer.

Vi-da: vitiligo diagnostic assistance mobile application

Science.gov (United States)

Nugraha, G. A.; Nurhudatiana, A.; Bahana, R.

2018-03-01

Vitiligo is a skin disorder in which white patches of depigmentation appear on different parts of the body. Usually, patients come to hospitals or clinics to have their vitiligo conditions assessed. This can be very tiring to the patients, as vitiligo treatments usually take a relatively long period of time, which can range from months to years. To address this challenge, we present in this paper a prototype of an Android-based mobile application called Vi-DA, which stands for Vitiligo Diagnostic Assistance. Vi-DA consists of three subsystems, which are user sign-up subsystem, camera and image analysis subsystem, and progress report subsystem. The mobile application was developed in Java programming language and uses MySQL as the database system. Vi-DA adopts a vitiligo segmentation algorithm to segment input image into normal skin area, vitiligo skin area, and non-skin area. Results showed that Vi-DA gave comparable results to the previous system implemented in Matlab. User acceptance testing results also showed that all respondents agreed on the usefulness of the system and agreed to use Vi-DA again in the future. Vi-DA benefits both dermatologists and patients as not only a computer-aided diagnosis (CAD) tool but also as a smart application that can be used for self-assessment at home.

Ecuación de la vida

OpenAIRE

Garcia Nassar, Rodolfo Jose

2015-01-01

— Es igual a la lluvia, producto de un día nublado, frío y mal calcado. Un dibujo mal hecho, un guión mal escrito, un retrato mal pintado. — ¿De qué hablas? — La vida. — La vida no es un retrato. — Es lo que quiero que sea. — Es lo que quieres ver de la vida. Ciego a lo que quieres no significa que sea lo que quieres que sea. — Bien. Pues observa. Haré de ella lo que pueda para que sea lo que quiera. — ¿Y si fallas?

A preliminary investigation into the measurement of global thunderstorm incidence and electrosphere potential at Sanae, Antarctica

International Nuclear Information System (INIS)

Smart, C.A.

1980-01-01

One of the atmospheric parameters that may be affected by variations in the electrosphere potential is thunderstorm activity. The author made preliminary investigations into the simultaneous monitoring of global thunderstorm incidence and electrosphere potential. The author looked at the structure of the sun and the earth solar activity and solar emissions as well as the sun-weather relationships. Measurement were made by the author during 1978 at Sanae, Antarctica. The objective was to investigate the fluctuations of global thunderstorm activity and electrosphere potential and to establish some link between these and with solar activity. Potential gradient of the lower atmosphere was measured by means of a field mill and fluctuations taken to be representative of those of the electrosphere potential. Thunderstorm incidence was monitored by measurement of extra low frequency (ELF) electromagnetic noise radiated by lightning. A dipole or loop antenna was used for the recording of extra low frequency electromagnetic noise. A computer program was developed to facilitate the data analysis

Vida extraterrestre

OpenAIRE

Guerrero, Ricardo, 1943-; Berlanga Herranz, Mercedes

2012-01-01

L'univers és ple de núvols de gas, pols i matèria orgànica. Els radiotelescopis han detectat la presència d"aigua i gran varietat de molècules orgàniques, peces essencials per al meccano de la vida.

Use of Geographic Information Systems to sole the inadequacy of cartographic boundaries of the Environmental Preservation Area of Sana – Macaé, RJ

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Carlos André Luz Jeronymo

2013-07-01

Full Text Available The Environmental Preservation Area (EPA of Sana is a Municipal Conservation Unit with private and public lands in the rural area of Macaé. This region has been densely occupied, due to the increase of tourism and urban rowth. This EPA has a Management Plan and Environmental Zoning to regulate nature conservation with sustainable use of local natural resources. As the Environmental Zoning is the most important tool to support decisions made by EPA, an evaluation of the cartographic adequacy of its limits was conducted in this study

VIDA, VOLUNTAD DE PODER Y DESAPROPIACION: UNA LECTURA SOBRE LA NOCION MADURA-TARDIA DE VIDA EN NIETZSCHE

OpenAIRE

TERRA POLANCO, CONSTANZA

2012-01-01

La presente investigación tiene como propósito indagar el concepto de vida en Nietzsche presente en su obra madura-tardía y póstuma. Este concepto de vida nietzscheano fue engendrado a la par de uno de sus pensamientos más célebres, a saber, la voluntad de poder. De esta manera, esta tesis se concentrará en la lectura, análisis e interpretación de la idea de vida en Nietzsche a la luz de la voluntad de poder. Lo que se propone en esta tesis es, por un lado, determinar qué se...

The effect of metformin on the recurrence of colorectal adenoma in diabetic patients with previous colorectal adenoma.

Science.gov (United States)

Han, Min Seok; Lee, Hyun Jung; Park, Soo Jung; Hong, Sung Pil; Cheon, Jae Hee; Kim, Won Ho; Kim, Tae Il

2017-08-01

Existing studies suggest that metformin lowers the risk and mortality of colorectal cancer. However, the effect of metformin on the suppression and prevention of colorectal adenomas is not clear. The aim of this study was to evaluate the effect of metformin on the recurrence of colorectal adenoma in diabetic patients with previous colorectal adenoma. Among 423 diabetic patients who underwent surveillance colonoscopy after resection of colorectal adenoma between 2005 and 2011, 257 patients were retrospectively reviewed. The patients were divided into two groups: one group comprising 106 patients who took metformin and another group comprising 151 patients who did not take metformin. The clinical characteristics, colorectal adenoma recurrence, and valuable factors for adenoma recurrence were analyzed. At surveillance colonoscopy after colonoscopic polypectomy for adenoma, 38 patients (35.8%) exhibited colorectal adenoma among 106 patients who took metformin, compared with 85 patients (56.3%) with colorectal adenoma among 151 patients who did not take metformin (odds ratio 0.434, 95% confidence interval 0.260-0.723, P = 0.001). Multivariate Cox analysis showed that metformin was associated with decreased recurrence of colorectal adenoma (hazard ratio 0.572, 95% confidence interval 0.385-0.852, P = 0.006) in diabetic patients with previous colorectal adenoma. The cumulative probability of colorectal adenoma recurrence was significantly lower in the metformin group than in the non-metformin group (P = 0.001). Metformin use in diabetic patients with previous colorectal adenoma is associated with a lower risk of colorectal adenoma recurrence.

Búsqueda de vida en Marte

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Rafael Navarro-González

2005-01-01

Full Text Available La misión astrobiológica más importante que se ha realizado hasta la fecha ha sido sin duda el proyecto Vikingo de la NASA. Esta misión consistió en tres experimentos biológicos especialmente diseñados para la búsqueda de indicadores de vida en las capas superficiales del suelo marciano. Los tres experimentos dieron resultados positivos. Sin embargo, el análisis de materia orgánica en el suelo marciano demostró la ausencia total de carbono orgánico. Este hallazgo fue utilizado como uno de los argumentos más sólidos en contra de la existencia de vida en la superficie del planeta Marte. Como preparación para futuras misiones a Marte en búsqueda de vida es necesario probar los instrumentos en localidades terrestres que pudieran ser ambientes análogos a Marte. Uno de los desiertos más áridos del planeta es el de Atacama, en el norte de Chile. Estudios químicos y microbiológicos del suelo de Atacama sugieren que el corazón del desierto es en realidad un buen análogo de Marte, ya que no posee vida macroscópica y microscópica, tiene niveles muy bajos de materia orgánica, y sus suelos son muy reactivos. En colaboración con científicos franceses y estadounidenses, estamos preparando una misión robótica dirigida por la NASA para la búsqueda de vida pasada o presente en Marte por lo que el Desierto de Atacama en Chile es el escenario para la preparación de esta misión espacial.

Family history of prostate and colorectal cancer and risk of colorectal cancer in the Women's health initiative.

Science.gov (United States)

Beebe-Dimmer, Jennifer L; Yee, Cecilia; Paskett, Electra; Schwartz, Ann G; Lane, Dorothy; Palmer, Nynikka R A; Bock, Cathryn H; Nassir, Rami; Simon, Michael S

2017-12-13

Evidence suggests that risk of colorectal and prostate cancer is increased among those with a family history of the same disease, particularly among first-degree relatives. However, the aggregation of colorectal and prostate cancer within families has not been well investigated. Analyses were conducted among participants of the Women's Health Initiative (WHI) observational cohort, free of cancer at the baseline examination. Subjects were followed for colorectal cancer through August 31st, 2009. A Cox-proportional hazards regression modeling approach was used to estimate risk of colorectal cancer associated with a family history of prostate cancer, colorectal cancer and both cancers among first-degree relatives of all participants and stratified by race (African American vs. White). Of 75,999 eligible participants, there were 1122 colorectal cancer cases diagnosed over the study period. A family history of prostate cancer alone was not associated with an increase in colorectal cancer risk after adjustment for confounders (aHR =0.94; 95% CI =0.76, 1.15). Separate analysis examining the joint impact, a family history of both colorectal and prostate cancer was associated with an almost 50% increase in colorectal cancer risk (aHR = 1.48; 95% CI = 1.04, 2.10), but similar to those with a family history of colorectal cancer only (95% CI = 1.31; 95% CI = 1.11, 1.54). Our findings suggest risk of colorectal cancer is increased similarly among women with colorectal cancer only and among those with both colorectal and prostate cancer diagnosed among first-degree family members. Future studies are needed to determine the relative contribution of genes and shared environment to the risk of both cancers.

Screening for colorectal cancer.

Science.gov (United States)

He, Jin; Efron, Jonathan E

2011-01-01

March is national colorectal cancer awareness month. It is estimated that as many as 60% of colorectal cancer deaths could be prevented if all men and women aged 50 years or older were screened routinely. In 2000, Katie Couric's televised colonoscopy led to a 20% increase in screening colonoscopies across America, a stunning rise called the "Katie Couric Effect". This event demonstrated how celebrity endorsement affects health behavior. Currently, discussion is ongoing about the optimal strategy for CRC screening, particularly the costs of screening colonoscopy. The current CRC screening guidelines are summarized in Table 2. Debates over the optimum CRC screening test continue in the face of evidence that 22 million Americans aged 50 to 75 years are not screened for CRC by any modality and 25,000 of those lives may have been saved if they had been screened for CRC. It is clear that improving screening rates and reducing disparities in underscreened communities and population subgroups could further reduce colorectal cancer morbidity and mortality. National Institutes of Health consensus identified the following priority areas to enhance the use and quality of colorectal cancer screening: Eliminate financial barriers to colorectal cancer screening and appropriate follow-up of positive results of colorectal cancer screening. Develop systems to ensure the high quality of colorectal cancer screening programs. Conduct studies to determine the comparative effectiveness of the various colorectal cancer screening methods in usual practice settings. Encouraging population adherence to screening tests and allowing patients to select the tests they prefer may do more good (as long as they choose something) than whatever procedure is chosen by the medical profession as the preferred test.

Colorectal Cancer: A Personal Journey

Science.gov (United States)

... of this page please turn JavaScript on. Feature: Colorectal Cancer Colorectal Cancer: A Personal Journey Past Issues / Summer 2016 Table ... Carmen Marc Valvo is an outspoken voice for colorectal cancer screening. Photo Courtesy of: Phil Fisch Photography Designer ...

Qualidade de vida de graduandos de enfermagem

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Beatriz Marques de Oliveira

2011-02-01

Full Text Available O presente estudo objetivou descrever o perfil sociodemográfico dos estudantes de enfermagem e compreender o significado atribuído para sua atual qualidade de vida. Foram entrevistados 65 acadêmicos do 8º semestre do ano de 2007, por meio da aplicação de questionário autoreferido, com informações de dados sociodemográficos e questões abertas sobre qualidade de vida. A população de estudo foi predominantemente do sexo feminino, solteira, com idade entre 22 a 24 anos e com diferentes percepções sobre sua qualidade de vida, apreendidas por meio da vivência de fatores favoráveis e desfavoráveis no decorrer dos anos de aprendizado. O estudo destacou a percepção da qualidade de vida sob a ótica do estudante de enfermagem

Qualidade de vida de graduandos de enfermagem

Directory of Open Access Journals (Sweden)

Beatriz Marques de Oliveira

Full Text Available O presente estudo objetivou descrever o perfil sociodemográfico dos estudantes de enfermagem e compreender o significado atribuído para sua atual qualidade de vida. Foram entrevistados 65 acadêmicos do 8º semestre do ano de 2007, por meio da aplicação de questionário autoreferido, com informações de dados sociodemográficos e questões abertas sobre qualidade de vida. A população de estudo foi predominantemente do sexo feminino, solteira, com idade entre 22 a 24 anos e com diferentes percepções sobre sua qualidade de vida, apreendidas por meio da vivência de fatores favoráveis e desfavoráveis no decorrer dos anos de aprendizado. O estudo destacou a percepção da qualidade de vida sob a ótica do estudante de enfermagem

Developments in Colorectal Cancer Screening

Science.gov (United States)

... of this page please turn JavaScript on. Feature: Colorectal Cancer Developments in Colorectal Cancer Screening Past Issues / Summer 2016 Table of ... at the National Cancer Institute, shared developments in colorectal cancer screening methods with NIH MedlinePlus magazine. What ...

Improving Quality in Colorectal Surgery

NARCIS (Netherlands)

J.C. Slieker (Juliette)

2014-01-01

markdownabstract__Abstract__ Colorectal surgery is an important aspect of our current health system, due to the high incidence of colorectal cancer combined with an ageing population, improved long-term outcomes after colorectal surgery, and the perfectioning of the operative and postoperative

Absorption of cosmic radio noise at different frequencies at Sanae

International Nuclear Information System (INIS)

Steyn, T.F.J.

1983-12-01

Electron density profiles are simulated as a function of altitude for the D- and E-regions during disturbed ionospheric conditions using auroral absorption data from riometers recording cosmic radio noise at 20, 30 and 51 MHz at Sanae, Antarctica. An elliptical function was used to simulate, as a function of height, the electron density profiles. Using these profiles the measured absorption was calculated by utilizing the Appleton-Hartree treatment for radio waves crossing the ionosphere. The frequency dependence of the riometer absorption is represented by a power law of the frequency: A(f) = C.f -n , and values of n were determined from calculations of the absorptions from the simulated electron density profiles. This power law is a fairly accurate representation in the frequency range 20 to 51 MHz. It appears that the exponent of the power law and the height of maximum absorption are effective parameters to determine the hardness of the energy spectra of precipitating electrons. A method is discussed whereby interferences on the riometer recordings are filtered from the data. Quiet day curves are obtained by the superposition of successive riometer recordings with a period of one sidereal day. A Fourier series is fitted to the points of maximum density to represent the quiet day recordings. Absorption events on day 175 and day 178 (1982) are analized for each riometer frequency, and the hardness of the precipitating electrons is inferred from the n-values of power law presentation. It is shown that the absorption of cosmic radio noise increases by increasing the depth of ionization without increasing the ionization rate (number of electrons /m 3 ) in the upper D-region. This may mean that a hardening of a precipitation spectrum will increase the absorption of cosmic radio noise

Hablemos del derecho a la vida

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Hernán Olano García

2016-12-01

Full Text Available Con el objetivo de resaltar el valor del derecho fundamental dentro de los derechos fundamentales, de acuerdo con la Constitución Política de Colombia (y a otras constituciones y, dentro de su línea de investigación en historia de las instituciones-I, el autor realiza algunas reflexiones acerca del derecho a la vida, siguiendo una metodología deductiva, de acuerdo con los aspectos más importantes que tanto la doctrina, como la jurisprudencia le han aportado para estructurar el artículo en varios acápites como: (i su carácter sagrado, (ii ¿Un derecho a la muerte?, (iii la dignidad ontológica de la vida y (iv el día de la vida, que reconoce la protección de este derecho de toda persona, como fundamento y fin de todo el orden social justo. La conclusión principal a la que se llega es el valor sagrado y jurídico de la vida humana, dotada de trascendencia en el ordenamiento positivo por su origen natural.  

Producción orgánica para una alimentación sana

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Evangelina Méndez

2016-06-01

Full Text Available El presente trabajo se relaciona con la importancia del uso de fertilizantes o abonos orgánicos, como base para la producción de alimentos orgánicos, que incluye pruebas de laboratorio y la instrumentalización de encuestas a los grupos objetivos de insumos y productos orgánicos. Este artículo tiene como propósito dar a conocer los beneficios nutritivos de los productos orgánicos. El cuidado del medio ambiente y el interés por una alimentación sana han dado lugar al uso de fertilizantes orgánicos en cultivos, facilitando la producción de alimentos frescos y sanos, libres de sustancias tóxicas conocidos como alimentos orgánicos. Durante las actividades del proyecto de investigación IC-ULVRG12-10 "GUIA PARA EXPORTAR ABONO ORGANICO HACIA LOS PRINCIPALES MERCADOS DE ESTADOS UNIDOS, EUROPA y SUDAMERICA" la muestra encuestada demostró que no se encuentra lo suficientemente concientizada sobre el uso y beneficio de los productos orgánicos, sin embargo existe interés por parte del consumidor al consultar directamente en el lugar de compra sobre los mismos, especialmente los vegetales. Durante la investigación experimental las pruebas de laboratorio confirman el alto valor nutricional que aportan los abonos orgánicos al suelo y a las plantas.

De una vida amenazada a una vida anhelada: Atisbos a una teología de la vida en diálogo con la literatura

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Alberto Toutin

2007-01-01

Full Text Available En el seminario interno de la Facultad nos hemos interrogado acerca de la vida, ese misterio fascinante y vulnerable a la vez. En ese marco, hemos querido escuchar la voz de los escritores, en dos novelas. Pedro Páramo (1955 del escritor mexicano Juan Rulfo (1917-1986 y La Amortajada (1938 de la escritora chilena María Luisa Bombal (1910-1980. En ambos casos sus protagonistas nos hablan desde el otro lado del sentido de la vida, desde la muerte, pero para radicalizar la pregunta acerca del sentido de la vida, de los encuentros que las han marcado, del cuerpo como mediación de esos encuentros. Un diálogo desde estas figuras del más allá de la vida en las que resuenan con una honda actualidad las grandes temáticas escatológicas de la teología paulina, acerca de la vida eterna como un estar para siempre con el Señor, y acerca del cuerpo con el que resucitaremosLife, that mystery at once fascinating and vulnerable, was examined at a recent faculty seminar. Within this framework, the author of this article endeavors to listen to the voice of the writers of two novels: Pedro Páramo (1955 by the Mexican writer Juan Rulfo (1917-1986, and La amortajada ["The Shrouded Woman"] (1938 by the Chilean writer María Luisa Bombal (1910-1980. In both cases the literary characters speak to us from the other side of the grave, in order to radicalize questions about life, about the meetings that have marked the characters, about the body as mediation of those meetings. Thus, a dialogue emerges from these figures beyond life, in which the great eschatological themes of Pauline theology resonate forcefully and, at the same time, permit a deep reflection upon eternal life as always being with the Lord, as well as regarding the kind of body with which we will rise again

Las categorías modo de vida, nivel, calidad y estilo de vida su relación con la Cultura Física Terapéutica

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Lucía Linares Hernández

2008-09-01

Full Text Available Para este trabajo tomamos en cuenta las categorías de la dialéctica en relación con la Cultura Física Terapéutica desde una reflexión critica que toma en consideración los criterios actuales de la vida moderna donde el hombre tiene gran dependencia de los avances de la tecnología, que los someten a un estado de hipoquinesia casi total, lo cual atenta contra su salud aumentando el riesgo a padecer de patología de tipo degenerativo ,patologías crónicas no trasmisibles ,que lo lleva y a un deterioro de la salud. Conociendo la importancia de la Cultura Física Terapéutica en la utilización adecuada del tiempo libre y su efecto en el cambio del estilo de vida de las personas estudiamos el comportamiento de estas categorías desde el punto de vista biomédico en la calidad de vida de los individuos según el estilo de vida que elijan .Además se evidenció que el estilo de vida influye directamente en la calidad de vida de los individuos independiente de la sociedad y del nivel de vida. La Cultura Física Terapéutica mejora la salud de la persona tanto sano, como enferma ya que utiliza el ejercicio físico como proceder que irrumpe el tiempo libre modificando el estilo de vida. El modo y nivel de vida puede influir en la calidad de vida de las personas, pero no es determinante en el cambio del estilo de vida Es indudable la relación de esta última categoría y la Cultura Física Terapéutica que toma matices diferentes según las formaciones económico-sociales sin desatender su esencia.

Sobre el derecho a la vida y la eutanasia

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Rafael Chamorro Fletes

2001-06-01

Full Text Available En este artículo se analizan los problemas que se derivan del conflicto entre el derecho a la vida y la eutanasia, estudiando el efecto que produce considerar el derecho a la vida como un derecho discrecional 0 como un derecho obligatorio; todo ello, relacionándolo con la teoría de los límites de los derechos fundamentales y con los tipos de eutanasia que podemos distinguir: voluntaria, involuntaria y no voluntaria. También se aborda cómo el proceso de desacralización de la vida, al hacer más énfasis en la calidad de la vida realiza una transición del concepto de "vida sagrada" al de "dignidad de la persona" en Cuanto supremo valor humano, intentando con esto aportar una solución. En definitiva se presenta el análisis de un conflicto que requiere la ponderación de bienes tan preciados como la vida, la autonomía y la dignidad humana.

Valoraciones de calidad en alimentos orgánicos y de origen local entre consumidores de la red Comida Sana y Cercana en Chiapas

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Cynthia Gutiérrez Pérez

2013-01-01

Full Text Available El trabajo expone cómo los consumidores valoran la calidad de los alimentos orgánicos de origen local. La información fue obtenida mediante un cuestionario aplicado a 50 consumidores asiduos a la red Comida Sana y Cercana en San Cristóbal de Las Casas, Chiapas, y mediante la realización de dos talleres. Los resultados indican que la calidad se define desde aspectos organolépticos, que los consumidores están interesados en el modelo de certificación participativa, y que depositan su confianza en la relación de cercanía entre productores y consumidores.

Identification of Kininogen 1 as a Serum Protein Marker of Colorectal Adenoma in Patients with a Family History of Colorectal Cancer

Science.gov (United States)

Yu, Jiekai; Huang, Yanqin; Lin, Chen; Li, Xiaofen; Fang, Xuefeng; Zhong, Chenhan; Yuan, Ying; Zheng, Shu

2018-01-01

The serum protein markers of colorectal adenoma in patients with a family history of colorectal cancer have been rarely reported. Serum samples from colorectal adenoma patients with or without a family history of colorectal cancer and healthy controls were profiled using Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS). The model to distinguish colorectal adenoma patients with a family history of colorectal cancer from atypical hereditary colorectal families (CRA-H) and sporadic colorectal adenoma patients without a family history of colorectal cancer (CRA-S) was established with 85.0% accuracy. The model distinguishing CRA-H from healthy individuals was established with 90.0% specificity and 86.7% sensitivity. Additionally, five peaks (2202, 5821, 3260, 2480, and 2218) showing differential expression in advanced colorectal adenoma patients with a family history of colorectal cancer were selected. The protein Kininogen 1 (KNG1) was identified in colorectal adenoma patients and validated using Western Blotting. KNG1 may be a biomarker for colorectal adenoma patients with a family history of colorectal cancer. PMID:29535795

Beclin 1 Expression is Closely Linked to Colorectal Carcinogenesis and Distant Metastasis of Colorectal Carcinoma

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Mei-Ying Zhang

2014-08-01

Full Text Available Beclin 1 participates in development, autophagy, differentiation, anti- apoptosis, neurodegeneration, tumorigenesis and cancer progression. The roles of Beclin 1 in colorectal carcinogenesis and its subsequent progression are still unclear. Here, the mRNA and protein expression of Beclin 1 were determined in colorectal carcinoma and matched mucosa by Reverse transcriptase-polymerase chain reaction and Western blot. Immunohistochemistry and in situ hybridization (ISH were performed on tissue microarryer with colorectal carcinoma, adenoma and mucosa. The expression of Beclin 1 mRNA and protein was found to be higher in colorectal carcinoma than matched mucosa by real-time PCR and Western blot (p < 0.05. According to the ISH data, Beclin 1 expression was lower in colorectal non-neoplastic mucosa (NNM than adenoma and carcinoma (p < 0.05. Immunohistochemically, primary carcinoma showed stronger Beclin 1 expression than NNM and metastatic carcinoma in the liver (p < 0.05. Beclin 1 protein expression was negatively related to liver and distant metastasis (p < 0.05, but not correlated with age, sex, depth of invasion, lymphatic or venous invasion, lymph node metastasis, tumor-node-metastasis (TNM staging, differentiation or serum carcinoembryonic antigen (CEA concentration (p > 0.05. Survival analysis indicated that Beclin 1 expression was not linked to favorable prognosis of the patients with colorectal carcinoma (p > 0.05. Cox’s model indicated that depth of invasion and distant metastasis were independent prognostic factors for colorectal carcinomas (p < 0.05. It was suggested that Beclin 1 expression is closely linked to colorectal carcinogenesis and distant metastasis of colorectal carcinoma.

Microbiota, Inflammation and Colorectal Cancer

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Cécily Lucas

2017-06-01

Full Text Available Colorectal cancer, the fourth leading cause of cancer-related death worldwide, is a multifactorial disease involving genetic, environmental and lifestyle risk factors. In addition, increased evidence has established a role for the intestinal microbiota in the development of colorectal cancer. Indeed, changes in the intestinal microbiota composition in colorectal cancer patients compared to control subjects have been reported. Several bacterial species have been shown to exhibit the pro-inflammatory and pro-carcinogenic properties, which could consequently have an impact on colorectal carcinogenesis. This review will summarize the current knowledge about the potential links between the intestinal microbiota and colorectal cancer, with a focus on the pro-carcinogenic properties of bacterial microbiota such as induction of inflammation, the biosynthesis of genotoxins that interfere with cell cycle regulation and the production of toxic metabolites. Finally, we will describe the potential therapeutic strategies based on intestinal microbiota manipulation for colorectal cancer treatment.

Vidas célebres, vidas minúsculas: Vasari, Foucault, Michon

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Kelvin Falcão

2014-12-01

Full Text Available O primeiro movimento deste ensaio consiste no esboço de um percurso breve a partir da obra de Michel Foucault, rastreando o uso do significante “vidas” em alguns textos do autor francês. Dois eixos são delineados a partir daí: o primeiro deles diz respeito à leitura foucaultiana das “vidas célebres” de Giorgio Vasari; o segundo diz respeito às “vidas infames”, que Foucault rastreia nos arquivos policiais franceses. Em seguida, inicia-se um desvio em direção à literatura do século XX, considerando o envolvimento da ficção com a emergência da discursividade biográfica, sua ressonância política e o emprego crítico, mais uma vez, do significante “vidas”. Com esse contexto de fundo estabelecido, o ensaio conclui-se com uma análise de Vidas minúsculas, do escritor francês Pierre Michon. The first movement of this essay is to outline a brief path from the work of Michel Foucault, tracking the use of the signifier “lives” in some texts of the French author. Two axes are delineated from there, the first one concerns Foucault’s reading of “renowed lives” by Giorgio Vasari; the second concerns the “infamous lives”, which Foucault traces from the French police files. Then begins a shift toward twentiethcentury literature, considering the involvement of fiction with the emergence of biographical discourse, its political resonance and, again, the critical use of the signifier “lives”. With this background context established, the essay concludes with a analysis of Small Lives, by French writer Pierre Michon.

EL ARTE ES VIDA Y LA VIDA ES ARTE: LA PINTURA DE JOSÉ DEL CARMEN HERNÁNDEZ

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Bogdan Piotrowski

2014-01-01

Full Text Available Se presenta aquí la obra artística de José del Carmen Hernández desde la premisa según la cual, al valorar su pintura podemos hablar del arte de la vida y de la vida artística plena. Se resalta su esforzada trayectoria de vida que lo ha llevado desde un humilde origen campesino hasta la formación artística académica y a través de tertulias de artistas en diferentes partes del mundo. Al destacar su obra pictórica, escultórica, mural y abstracta, se concluye con el vínculo actual del artista con su propia realidad y la esperanza como motor de su obra frente a la constata - ción de las violencias persistentes.

Qualidade de vida de pacientes com câncer colorretal em uso de suplementação dietética com fungos Agaricus sylvaticus após seis meses de segmento: ensaio clínico aleatorizado e placebo-controlado Quality of life of patients with colorectal cancer on dietary supplementation with Agaricus sylvaticus fungus: after six months of segment: randomized and placebo-controlled clinical trial

Directory of Open Access Journals (Sweden)

Renata Costa Fortes

2007-06-01

Full Text Available INTRODUÇÃO: O câncer gastrointestinal compromete a qualidade de vida devido às alterações fisiológicas, metabólicas e psicológicas. Fungos medicinais podem melhorar a qualidade de vida de pacientes com câncer. OBJETIVO: Avaliar os efeitos da suplementação dietética com fungos Agaricus sylvaticus na qualidade de vida de pacientes com câncer colorretal em fase pós-operatória. METODOLOGIA: Ensaio clínico randomizado, duplo-cego, placebo-controlado, realizado no Hospital de Base do Distrito Federal. Amostra constituída por 56 pacientes (24 homens e 32 mulheres, estádios I, II e III, separados em grupos placebo e Agaricus sylvaticus (30mg/kg/dia, e acompanhados por um período de seis meses. Para avaliar os indicadores da qualidade de vida foram utilizados um formulário-padrão e uma anamnese dirigida-padrão. Os resultados foram analisados de forma qualitativa e descritiva, utilizando os programas Microsoft Excel 2003 e Epi Info 2004. RESULTADOS: Após seis meses de tratamento, observou-se, no grupo Agaricus sylvaticus, aumento da adesão à prática de atividade física, melhora da disposição e do humor, redução das queixas de dores e das alterações do sono como insônia e noites mal dormidas comparado com o grupo placebo. CONCLUSÃO: Os resultados sugerem que a suplementação dietética com Agaricus sylvaticus pode melhorar a qualidade de vida de pacientes no pós-operatório de câncer colorretal.INTRODUCTION: Gastrointestinal cancer jeopardizes the quality of life through physiological, metabolic and psychological alterations. Medicinal fungus may boost the quality of life of patients with cancer. OBJECTIVE: To evaluate the effects of the dietary supplementation with Agaricus sylvaticus fungus in relation to the quality of life in patients with colorectal cancer during post-surgery phase. METHODOLOGY: Randomized, double-blind, placebo-controlled clinical trial carried out at the Federal District Hospital - Brazil, for

LA VIDA AL NATURAL Y LA INVENCIÓN DE LA VIDA

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Fábio de Melo Sene

2010-12-01

Full Text Available El concepto de vida, bajo el punto de vista biológico, con énfasis en lareproducción, principal característica de los seres vivos, es presentadohistóricamente articulado con los diversos embates o cuestiones éticas,morales, y o legales, a lo largo de ese recorrido histórico, de acuerdo con elconsenso relativo a cada época. Inicialmente, fue establecida la distinciónnecesaria entre procesos naturales y procesos resultantes de accionesantrópicas. Se consideró como invención todo procedimiento o hacerrelativos al desarrollo cultural de la humanidad. Así, a lo largo del recorridose confrontan posiciones pasadas y actuales, haciéndose amplia discusión alrespecto de asuntos recientes como: fecundación artificial, clonación,transgénicos, células-madre y la creación de vida en el laboratorio.

Lysyl oxidase in colorectal cancer

DEFF Research Database (Denmark)

Cox, Thomas R; Erler, Janine T

2013-01-01

Colorectal cancer is the third most prevalent form of cancer worldwide and fourth-leading cause of cancer-related mortality, leading to ~600,000 deaths annually, predominantly affecting the developed world. Lysyl oxidase is a secreted, extracellular matrix-modifying enzyme previously suggested...... to act as a tumor suppressor in colorectal cancer. However, emerging evidence has rapidly implicated lysyl oxidase in promoting metastasis of solid tumors and in particular colorectal cancer at multiple stages, affecting tumor cell proliferation, invasion, and angiogenesis. This emerging research has...... advancements in the field of colorectal cancer....

Prophylaxis against colorectal cancer

DEFF Research Database (Denmark)

Bülow, Steffen; Kronborg, O

1996-01-01

Colorectal cancer is diagnosed in more than 3000 people every year in Denmark, with a population of 5 million, and 2000 die from this disease every year. The aetiology of the disease is complex, but an increasing number of cancers have been related to genetics and Denmark is contributing...... with a well-established register of familial adenomatous polyposis and a recently founded register for hereditary nonpolyposis colorectal cancer, both with major international relationships. The Danish tradition of epidemiology and clinical trials has also been demonstrated in population screening trials...... for colorectal cancer in average-risk persons as well as high-risk groups with precursors of the disease. The present review places Danish contributions within the prophylaxis of colorectal cancer during the last decade in an international context....

Hereditary colorectal cancer diagnostics

DEFF Research Database (Denmark)

Klarskov, Louise; Holck, Susanne; Bernstein, Inge

2012-01-01

BackgroundThe hereditary non-polyposis colorectal cancer (HNPCC) subset of tumours can broadly be divided into tumours caused by an underlying mismatch-repair gene mutation, referred to as Lynch syndrome, and those that develop in families with similar patterns of heredity but without disease......-predisposing germline mismatch repair mutations, referred to as familial colorectal cancer type X (FCCTX). Recognition of HNPCC-associated colorectal cancers is central since surveillance programmes effectively reduce morbidity and mortality. The characteristic morphological features linked to Lynch syndrome can aid...... in the identification of this subset, whereas the possibility to use morphological features as an indicator of FCCTX is uncertain.Objective and methodsTo perform a detailed morphological evaluation of HNPCC-associated colorectal cancers and demonstrate significant differences between tumours associated with FCCTX...

[Oligometastasized colorectal cancer-modern treatment strategies].

Science.gov (United States)

Binnebösel, M; Lambertz, A; Dejong, K; Neumann, U P

2018-06-05

The prognosis of colorectal cancer in UICC stage IV has been improved in the last decades by improvements in interdisciplinary treatment. Treatment strategies for oligometastasized colorectal cancer are developing more and more into an individualized treatment. An overview of the current literature of modern treatment concepts in oligometastasized colorectal cancer UICC stage IV is given. Surgery still has the supreme mandate in resectable colorectal liver metastases, as neoadjuvant and adjuvant treatment strategies to not provide any benefits for these patients. In marginal or non-resectable stages systemic treatment is superior in these patients depending on the prognostic parameters. Also in curative settings local treatment options should be considered as a reasonable additive tool. An interesting treatment approach for isolated liver metastases and non-resectable colorectal cancer is liver transplantation. Irrespective of new developments in treatment strategies for metastasized colorectal cancer, resection of colorectal liver metastases remains the gold standard whenever possible.

Prophylaxis against colorectal cancer

DEFF Research Database (Denmark)

Bülow, Steffen; Kronborg, O

1996-01-01

Colorectal cancer is diagnosed in more than 3000 people every year in Denmark, with a population of 5 million, and 2000 die from this disease every year. The aetiology of the disease is complex, but an increasing number of cancers have been related to genetics and Denmark is contributing with a w......Colorectal cancer is diagnosed in more than 3000 people every year in Denmark, with a population of 5 million, and 2000 die from this disease every year. The aetiology of the disease is complex, but an increasing number of cancers have been related to genetics and Denmark is contributing...... with a well-established register of familial adenomatous polyposis and a recently founded register for hereditary nonpolyposis colorectal cancer, both with major international relationships. The Danish tradition of epidemiology and clinical trials has also been demonstrated in population screening trials...... for colorectal cancer in average-risk persons as well as high-risk groups with precursors of the disease. The present review places Danish contributions within the prophylaxis of colorectal cancer during the last decade in an international context....

Relationship between nutritional status and immediate complications in patients undergoing colorectal surgery

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Vanina Cordeiro de Souza

2013-04-01

Full Text Available Introduction: several complications may occur during colorectal surgical procedures and fac- tors, such as nutritional status, substantially contribute to this problem. Objective: evaluate the relationship between nutritional status (determined by different tools and the emergence of early postoperative complications, as well as analyze social parameters, lifestyle, food intake, and time to diet reintroduction. Methods: case series study conducted in the surgical proctologic ward of the Hospital Barão de Lucena, Recife, Pernambuco, with individuals of both sexes diagnosed with colorectal cancer who underwent a surgical procedure involving at least one anastomosis. Social, de- mographic and clinical data, life style, dietary intake, nutritional status, and the immediate postsurgical complications were evaluated. Results: among the 31 patients studied, there was a higher prevalence of females (74.2%, mean age of 61.9 ± 12.4 years old, and the rectum was the primary site of cancer in 54.8%. Most patients came from the countryside, were retirees, had lower education, consumed too much red meat, processed meats, and fats, with low consumption of fruits and vegeta- bles, and were sedentary. Regarding nutritional status, nutritional risk was found in 58.1%, mean BMI of 25.7 ± 6.8 kg/m2, and 54.8% had significant weight loss. Additionally, 38.7% had some of the immediate complications, particularly paralytic ileus and abdominal dis- tension. There was a delay in the onset of renourishment, and there was no association between nutritional status and immediate complications. Conclusion: colorectal cancer is closely related to eating habits and lifestyle. Patients with this malignancy have a marked weight loss; however, in this study, we found no association between nutritional status and the incidence of postoperative complications. Resumo: Introdução: intervenções cirúrgicas colorretais estão sujeitas a diversas complicações e vários fatores

Aprendizajes en sincronía con la vida

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Flor Abarca-Alpízar

2017-08-01

Full Text Available Como humanidad sufrimos la desconexión y separación con la vida toda. Esta ruptura impuesta por el paradigma mecanicista predominante en los últimos cuatrocientos años, nos ha llevado a olvidar la visión holista promovida por las culturas originarias y ancestrales. Esta situación prevalece también en los sistemas educativos dominados por la enseñanza memorística y fragmentada, alejada de la vida, del ser y sentir de las personas aprendientes. Para la superación de la crisis planetaria actual es urgente recuperar la visión holista de la vida y del aprendizaje, para lo cual los procesos docentes universitarios son claves para la formación de personas profesionales comprometidas con la plenitud de la vida sobre la tierra. El sentido de este ensayo es reflexionar sobre la importancia que tiene para la superación de la crisis planetaria actual la recuperación de nuestra conectividad con la vida del planeta tierra en sincronicidad con los aprendizajes, porque los procesos vitales y los procesos de aprendizaje son la misma cosa. Este ensayo está organizado en tres momentos. El primero parte del intercambio de seres, saberes, sentires y experiencias para recuperar nuestra conexión perdida con la vida en nuestro planeta tierra. Un segundo momento donde presentamos reflexiones y conceptualización por medio de la construcción colectiva de conocimientos, con apoyo de personas especialistas en la visión holista y los procesos de interaprendizaje, necesarios para salvar la vida toda. El tercer momento de este ensayo está elaborado con propuestas, claves, signos y señales para la conexión de los procesos vitales en sincronía con los procesos de aprendizaje necesarios en los tiempos actuales.

Conceptos y definiciones de la vida y la muerte celular Conceptos y definiciones de la vida y la muerte celular

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Fernando Anaya Velázquez

2012-02-01

Full Text Available En el presente trabajo se revisa la información científica sobre las definiciones y conceptos sobre la vida y la muerte celular. Se describen las características generales de la vida biológica y los seres vivos, así como de la muerte celular. Aunque se sabe cómo ocurre la vida y la muerte de las células aún no se tiene una definición precisa de qué es la vida y qué es la muerte biológica. Finalmente, derivado de los recientes avances en la genómica sintética, se concluye que es necesario actualizar los conceptos y definiciones sobre la vida y la muerte en la biología. In the present work scientific concepts and definitions about life and cell death are revised.General properties of biological life and live organisms as well as cellular death are described.Although it is known how life and death occur in cells, a convincing definition is stilllacking on what are biological life and death. Finally, the recent reported experiments onsynthetic genomics raise the importance to updating concepts and definitions of life anddeath in biology.

El ser humano, su proyecto de vida vs. Calidad de vida en el trabajo como mediación

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Janis S. Gelves Peña

2010-01-01

Full Text Available Resumen:El Trabajo, en el ser humano, media las diferentes percepciones socioculturales, y puede ser el comienzo deanálisis personal para un autoconocimiento profundo. También puede ayudar para que los proyectos de vida de lostrabajadores sean construidos en la inter-fase individual y social, siempre suponiendo una intervención conjuntade elementos afectivos, cognitivos y sociales. Un proyecto de vida tiende a caracterizarse como la realizaciónde una vocación, representando el más armonioso encuentro posible entre las aspiraciones individuales y losPalabras Claves:Proyecto de Vida, Ser Humano, Educación, Calidad de Vida en el Trabajo, Satisfacción, Mediación.AbstractWork in humans, mediates the socio-cultural perceptions, and may be the beginning of personal analysis fora deeper self-knowledge. It can also help to ensure that projects of life of workers are constructed in the interindividualand social stage, always assuming a joint intervention of elements affective, cognitive and social. Aproject of life tends to be characterized as the realization of a vocation, representing the most harmonious meetingforemost as human being.Keywords:Life Project, Human Being, Education, Quality of Working Life, Satisfaction, Mediation.

Gallstones and colorectal cancer

DEFF Research Database (Denmark)

Jørgensen, Torben; Rafaelsen, Søren Rafael

1992-01-01

The prevalence of gallstone disease in 145 consecutive patients with colorectal cancer was compared with gallstone prevalence in 4,159 subjects randomly selected from a population. The group of patients had a significantly higher prevalence of gallstone disease than the population (odds ratio = 1...... substantial evidence for an association between gallstones and colorectal cancer, an association which is not due to cholecystectomy being a predisposing factor to colorectal cancer. Sporadic findings of an association between cholecystectomy and colorectal cancer can be explained by the above relationship........59; 95 percent confidence limits 1.04-2.45), whereas cholecystectomies occurred with equal frequency in the two groups. There was a nonsignificant trend toward more right-sided cancers in patients with gallstones than in patients without. These results, together with available literature, give...

Endoscopic management of colorectal adenomas.

Science.gov (United States)

Meier, Benjamin; Caca, Karel; Fischer, Andreas; Schmidt, Arthur

2017-01-01

Colorectal adenomas are well known precursors of invasive adenocarcinoma. Colonoscopy is the gold standard for adenoma detection. Colonoscopy is far more than a diagnostic tool, as it allows effective treatment of colorectal adenomas. Endoscopic resection of colorectal adenomas has been shown to reduce the incidence and mortality of colorectal cancer. Difficult resection techniques are available, such as endoscopic mucosal resection, endoscopic submucosal dissection and endoscopic full-thickness resection. This review aims to provide an overview of the different endoscopic resection techniques and their indications, and summarizes the current recommendations in the recently published guideline of the European Society of Gastrointestinal Endoscopy.

Colorectal cancer with venous tumor thrombosis

OpenAIRE

Kensuke Otani; Soichiro Ishihara; Keisuke Hata; Koji Murono; Kazuhito Sasaki; Koji Yasuda; Takeshi Nishikawa; Toshiaki Tanaka; Tomomichi Kiyomatsu; Kazushige Kawai; Hiroaki Nozawa; Hironori Yamaguchi; Toshiaki Watanabe

2018-01-01

Summary: Colorectal cancer is seldom accompanied by venous tumor thrombosis, and little is known about the features of venous tumor thrombosis in colorectal cancer. However, some reports show that colorectal cancer patients can develop venous tumor thrombosis and warn clinicians not to overlook this complication. In this report, we perform a review of 43 previously reported cases and investigate the characteristics of colorectal cancer accompanied by venous tumor thrombosis. The histological ...

Nutrients, foods, and colorectal cancer prevention.

Science.gov (United States)

Song, Mingyang; Garrett, Wendy S; Chan, Andrew T

2015-05-01

Diet has an important role in the development of colorectal cancer. In the past few decades, findings from extensive epidemiologic and experimental investigations have linked consumption of several foods and nutrients to the risk of colorectal neoplasia. Calcium, fiber, milk, and whole grains have been associated with a lower risk of colorectal cancer, and red meat and processed meat have been associated with an increased risk. There is substantial evidence for the potential chemopreventive effects of vitamin D, folate, fruits, and vegetables. Nutrients and foods also may interact, as a dietary pattern, to influence colorectal cancer risk. Diet likely influences colorectal carcinogenesis through several interacting mechanisms. These include the direct effects on immune responsiveness and inflammation, and the indirect effects of overnutrition and obesity-risk factors for colorectal cancer. Emerging evidence also implicates the gut microbiota as an important effector in the relationship between diet and cancer. Dietary modification therefore has the promise of reducing colorectal cancer incidence. Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.

Update on Sporadic Colorectal Cancer Genetics.

Science.gov (United States)

Hardiman, Karin M

2018-05-01

Our understanding of the genetics of colorectal cancer has changed dramatically over recent years. Colorectal cancer can be classified in multiple different ways. Along with the advent of whole-exome sequencing, we have gained an understanding of the scale of the genetic changes found in sporadic colorectal cancer. We now know that there are multiple pathways that are commonly involved in the evolution of colorectal cancer including Wnt/β-catenin, RAS, EGFR, and PIK3 kinase. Another recent leap in our understanding of colorectal cancer genetics is the recognition that many, if not all tumors, are actually genetically heterogeneous within individual tumors and also between tumors. Recent research has revealed the prognostic and possibly therapeutic implications of various specific mutations, including specific mutations in BRAF and KRAS . There is increasing interest in the use of mutation testing for screening and surveillance through stool and circulating DNA testing. Recent advances in translational research in colorectal cancer genetics are dramatically changing our understanding of colorectal cancer and will likely change therapy and surveillance in the near future.

Perceived religiousness is protective for colorectal cancer: data from the Melbourne Colorectal Cancer Study.

OpenAIRE

Kune, G A; Kune, S; Watson, L F

1993-01-01

The perceived or self-reported degree of 'religiousness' was obtained by interview from 715 colorectal cancer patients and 727 age/sex matched community controls, as part of a large, comprehensive population-based study of colorectal cancer incidence, aetiology and survival (The Melbourne Colorectal Cancer Study) conducted in Melbourne, Australia. Self-reported or perceived 'religiousness', as defined in the study, was a statistically significant protective factor [relative risk (RR) = 0.70, ...

Ultrasonographic findings in blunt abdominal trauma among Yemeni patients in Sana'a

International Nuclear Information System (INIS)

Al Najjar, A. A. H.

2004-09-01

A hundred and thirty patients (104 males, and 26 females) with suspected blunt abdominal trauma were admitted to this prospective study at Althawra hospital, Sana'a, Yemen in the period between june and december 2003. Real-time ultrasonography of the abdomen was performed in all patients. Fifty-six patients showed U/S evidence of visceral injury. Fourteen injuries of spleen, 7 had evidence of liver and 8 had renal injuries. Only eight needed a laparatomy because of cardiovascular instability and the laparatomy confirmed the ultrasound findings. The remainder were treated conservatively with good results. It is of interest that there was one ultrasonic sign of fluid in one patient who progressed well on conservative therapy. Ultrasonic signs of visceral laceration or contusion were found in patients who had 2 up to 8 sonic findings. It appears that visceral injury always gives more than two sonic signs. The remaining 33 patients only had intraperitoneal fluid, only one of them had volvulus. It is not possible to state the nature of fluid, whether it is an exudate, transudate, blood or lymph. Diagnostic peritoneal lavage would have been helpful. Seven patients died, most of them due to associated injuries, mainly head injury and cardiovascular collapse, one patient died on table and had retroperitonieal haematoma extending from pelvis to the mesentery of transverse colon and had no abdominal organ injury. The sensitivity of ultrasonography for liver was 87.5% and for spleen 100%. Ultrasonography is sensitive, safe, cost effective and non invasive method for screening patients with blunt abdominal trauma.(Author)

Calidad de vida y felicidad: no es exactamento lo mismo

NARCIS (Netherlands)

R. Veenhoven (Ruut)

2001-01-01

textabstractLa " Calidad de vida" se concibe como un amplio concepto que abarca tres significados: 1) Calidad del entorno en que vivimos; 2) Calidad de acción y 3) Disfrute subjetivo de la vida. La " Felicidad " se incluye en este último significado. Se define como la apreciación completa de la vida

Detection of colorectal neoplasia

DEFF Research Database (Denmark)

Wilhelmsen, Michael; Christensen, Ib J; Rasmussen, Louise

2017-01-01

Serological biomarkers may be an option for early detection of colorectal cancer (CRC). The present study assessed eight cancer-associated protein biomarkers in plasma from subjects undergoing first time ever colonoscopy due to symptoms attributable to colorectal neoplasia. Plasma AFP, CA19-9, CEA...... value was 18% and the negative predictive value was 97%. Combinations of serological protein biomarkers provided a significant identification of subjects with high risk of the presence of colorectal neoplasia. The present set of biomarkers could become important adjunct in early detection of CRC....

QUALIDADE DE VIDA DE IDOSOS COM MOBILIDADE FÍSICA PREJUDICADA

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Juliana Maria de Paula

2013-01-01

Full Text Available Se trata de una revisión integradora, con objetivo de identificar evidencias disponibles acerca del conocimiento sobre calidad de vida de ancianos con movilidad física perjudicada, entre 2001 y 2011. Los datos fueron recolectados en las bases de datos LILACS, MEDLINE y Cochrane. Después de lectura analítica de las obras, se seleccionaron 16 artículos para análisis en dos categorías temáticas: calidad de vida y satisfacción personal, y calidad de vida y capacidad funcional. Limitaciones de la movilidad, dolor y bienestar emocional de ancianos pueden ser atribuidas a enfermedades crónicas, que afectan negativamente la calidad de vida de ellos; y también, los ancianos que reportan baja calidad de vida, son los que tienen mayor grado de dependencia, influyendo en la participación social y bienestar. Se sugiere la actuación del enfermero en investigaciones de intervenciones que permitan mejorar la calidad de vida de ancianos con movilidad física perjudicada.

Cost-effectiveness of colorectal cancer screening

NARCIS (Netherlands)

I. Lansdorp-Vogelaar (Iris); A.B. Knudsen (Amy); H. Brenner (Hermann)

2011-01-01

textabstractColorectal cancer is an important public health problem. Several screening methods have been shown to be effective in reducing colorectal cancer mortality. The objective of this review was to assess the cost-effectiveness of the different colorectal cancer screening methods and to

Dietary patterns and colorectal cancer in a Japanese population: the Fukuoka Colorectal Cancer Study.

Science.gov (United States)

Kurotani, Kayo; Budhathoki, Sanjeev; Joshi, Amit Man; Yin, Guang; Toyomura, Kengo; Kono, Suminori; Mibu, Ryuichi; Tanaka, Masao; Kakeji, Yoshihiro; Maehara, Yoshihiko; Okamura, Takeshi; Ikejiri, Koji; Futami, Kitaroh; Maekawa, Takafumi; Yasunami, Yohichi; Takenaka, Kenji; Ichimiya, Hitoshi; Terasaka, Reiji

2010-12-01

Few studies have addressed the relation between dietary patterns and colorectal cancer in Japan. We investigated dietary patterns in relation to colorectal cancer risk in a community-based case-control study. The association with dietary patterns was also examined for different sites of colorectal cancer. Data were derived from the Fukuoka Colorectal Cancer Study, including 800 cases and 775 controls interviewed from September 2000 to December 2003. The cases were admitted to one of the participating hospitals for the first surgical treatment during this period. We identified dietary patterns using principal component analysis of intakes of twenty-nine items of food groups and specific foods. Quartile categories of each dietary pattern were used, and non-dietary lifestyle factors and total energy intake were adjusted for in the analysis. We identified three dietary patterns: prudent, high-fat and light-meal patterns. The prudent dietary pattern characterised by high intakes of vegetables, fruits, seafoods and soya foods showed a nearly significant protective association with the overall risk of colorectal cancer (trend P = 0.054), and it was statistically significantly related to a decreased risk of distal colon cancer (trend P = 0.002), but not to that of either proximal colon or rectal cancer. The high-fat and light-meal dietary patterns were not materially related to the overall or site-specific risk of colorectal cancer. In summary, a prudent dietary pattern was associated with a decreased risk of colorectal cancer, especially with that of distal colon cancer, in a fairly large case-control study in Japan.

Colorectal Cancer—Patient Version

Science.gov (United States)

Colorectal cancer often begins as a growth called a polyp inside the colon or rectum. Finding and removing polyps can prevent colorectal cancer. Start here to find information on colon and rectal cancer treatment, causes and prevention, screening, research, and statistics.

Primary prevention of colorectal cancer.

Science.gov (United States)

Chan, Andrew T; Giovannucci, Edward L

2010-06-01

Colorectal cancer has been strongly associated with a Western lifestyle. In the past several decades, much has been learned about the dietary, lifestyle, and medication risk factors for this malignancy. Although there is controversy about the role of specific nutritional factors, consideration of dietary pattern as a whole appears useful for formulating recommendations. For example, several studies have shown that high intake of red and processed meats, highly refined grains and starches, and sugars is related to increased risk of colorectal cancer. Replacing these factors with poultry, fish, and plant sources as the primary source of protein; unsaturated fats as the primary source of fat; and unrefined grains, legumes and fruits as the primary source of carbohydrates is likely to lower risk of colorectal cancer. Although a role for supplements, including vitamin D, folate, and vitamin B6, remains uncertain, calcium supplementation is likely to be at least modestly beneficial. With respect to lifestyle, compelling evidence indicates that avoidance of smoking and heavy alcohol use, prevention of weight gain, and maintenance of a reasonable level of physical activity are associated with markedly lower risks of colorectal cancer. Medications such as aspirin and nonsteroidal anti-inflammatory drugs and postmenopausal hormones for women are associated with substantial reductions in colorectal cancer risk, though their utility is affected by associated risks. Taken together, modifications in diet and lifestyle should substantially reduce the risk of colorectal cancer and could complement screening in reducing colorectal cancer incidence.

Microsatellite Status of Primary Colorectal Cancer Predicts the Incidence of Postoperative Colorectal Neoplasms.

Science.gov (United States)

Takiyama, Aki; Tanaka, Toshiaki; Yamamoto, Yoko; Hata, Keisuke; Ishihara, Soichiro; Nozawa, Hiroaki; Kawai, Kazushige; Kiyomatsu, Tomomichi; Nishikawa, Takeshi; Otani, Kensuke; Sasaki, Kazuhito; Watanabe, Toshiaki

2017-10-01

Few studies have evaluated the risk of postoperative colorectal neoplasms stratified by the nature of primary colorectal cancer (CRC). In this study, we revealed it on the basis of the microsatellite (MS) status of primary CRC. We retrospectively reviewed 338 patients with CRC and calculated the risk of neoplasms during postoperative surveillance colonoscopy in association with the MS status of primary CRC. A propensity score method was applied. We identified a higher incidence of metachronous rectal neoplasms after the resection of MS stable CRC than MS instable CRC (adjusted HR 5.74, p=0.04). We also observed a higher incidence of colorectal tubular adenoma in patients with MSS CRC (adjusted hazard ratio 7.09, pcolorectal cancer influenced the risk of postoperative colorectal neoplasms. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Industrial risk factors for colorectal cancer

International Nuclear Information System (INIS)

Lashner, B.A.; Epstein, S.S.

1990-01-01

Colorectal cancer is the second most common malignancy in the United States, and its incidence rates have sharply increased recently, especially in males. Industrial exposures, both occupational and environmental, are important colorectal cancer risk factors that are generally unrecognized by clinicians. Migration studies have documented that colorectal cancer is strongly associated with environmental risk factors. The causal role of occupational exposures is evidenced by a substantial literature associating specific work practices with increased colorectal cancer risks. Industrially related environmental exposures, including polluted drinking water and ionizing radiation, have also been associated with excess risks. Currently, there is a tendency to attribute colorectal cancer, largely or exclusively, to dietary and other lifestyle factors, thus neglecting these industrially related effects. Concerted efforts are needed to recognize the causal role of industrial risk factors and to encourage government and industry to reduce carcinogenic exposures. Furthermore, cost-effective screening programs for high-risk population groups are critically needed to further reduce deaths from colorectal cancer. 143 references

Robotic colorectal surgery: previous laparoscopic colorectal experience is not essential.

Science.gov (United States)

Sian, Tanvir Singh; Tierney, G M; Park, H; Lund, J N; Speake, W J; Hurst, N G; Al Chalabi, H; Smith, K J; Tou, S

2018-06-01

A background in minimally invasive colorectal surgery (MICS) has been thought to be essential prior to robotic-assisted colorectal surgery (RACS). Our aim was to determine whether MICS is essential prior to starting RACS training based on results from our initial experience with RACS. Two surgeons from our centre received robotic training through the European Academy of Robotic Colorectal Surgery (EARCS). One surgeon had no prior formal MICS training. We reviewed the first 30 consecutive robotic colorectal procedures from a prospectively maintained database between November 2014 and January 2016 at our institution. Fourteen patients were male. Median age was 64.5 years (range 36-82) and BMI was 27.5 (range 20-32.5). Twelve procedures (40%) were performed by the non-MICS-trained surgeon: ten high anterior resections (one conversion), one low anterior resection and one abdomino-perineal resection of rectum (APER). The MICS-trained surgeon performed nine high and four low anterior resections, one APER and in addition three right hemicolectomies and one abdominal suture rectopexy. There were no intra-operative complications and two patients required re-operation. Median post-operative stay was five days (range 1-26). There were two 30-day re-admissions. All oncological resections had clear margins and median node harvest was 18 (range 9-39). Our case series demonstrates that a background in MICS is not essential prior to starting RACS training. Not having prior MICS training should not discourage surgeons from considering applying for a robotic training programme. Safe and successful robotic colorectal services can be established after completing a formal structured robotic training programme.

Factores determinantes de la esperanza de vida en Chile

Directory of Open Access Journals (Sweden)

Planck Barahona-Urbina

2011-12-01

Full Text Available Introducción: En las últimas décadas, Chile ha experimentado un fuerte crecimiento económico, lo que ha permitido mejorar las condiciones de vida de los ciudadanos. Objetivos: Determinar los factores asociados a la esperanza de vida en Chile. Diseño: Análisis econométrico. Lugar: Chile. Intervenciones: Aplicación del modelo de regresión múltiple con series temporales para el análisis de la esperanza de vida en Chile. Se utilizó datos de naturaleza agregada del Instituto Nacional de Estadística (INE y el Banco Central de Chile para el período comprendido entre 1988 y 2008. Se utilizó como variable dependiente la esperanza de vida en años y, como variables explicativas, el PIB per cápita, número de médicos, número de enfermeras y gasto público en salud. Principales medidas de resultados: Factores asociados a la esperanza de vida. Resultados: Luego del análisis, los resultados han puesto de manifiesto que el ingreso per cápita, el número de médicos, número de enfermeras y el gasto en salud resultaron ser estadísticamente significativos, es decir, tienen un efecto positivo sobre la esperanza de vida de las personas. Conclusiones: A la luz de los resultados podría argumentarse lo beneficioso que puede resultar en términos cuantitativos un aumento del PIB per cápita a la hora de conseguir una mayor esperanza de vida de las personas. Igualmente, los resultados sugieren el efecto positivo que produce un incremento del número de personal médico en el país dado, pues esta variable ha permitido satisfacer la demanda sanitaria cada vez más creciente de la población. El aumento del presupuesto social en salud ha sido una variable que ha tenido un resultado positivo a la hora de valorar su efecto en la mejora de las condiciones de vida en Chile.

SUEÑO Y CALIDAD DE VIDA

Directory of Open Access Journals (Sweden)

Gualberto Buela-Casal

2005-06-01

Full Text Available Existe una estrecha interrelación entre los procesos de sueño y el estado general de salud física y psicológica de una persona. En el presente artículo se revisan algunas de las principales líneas de investigación que abordan las relaciones entre el sueño y la calidad de vida. Se analiza la influencia de los diferentes patrones de sueño (patrón de sueño corto, intermedio y largo y de la calidad del sueño (sueño eficiente/no eficiente en la salud y la calidad de vida. Se examinan las consecuencias sobre la salud de ciertos cambios en el sueño que son muy frecuentes en nuestro actual estilo de vida, tales como la privación de sueño o el trabajar en un sistema de turnos rotatorios o de trabajo nocturno, y de algunos de los trastornos del sueño más importantes como el insomnio o la apnea. El sueño es sin duda un excelente indicador del estado de salud de las personas tanto en muestras clínicas como en la población general. El desarrollo de estrategias preventivas y de intervención que reduzcan las alteraciones del sueño redundará en una mejor calidad de vida.

Screening for colorectal cancer

DEFF Research Database (Denmark)

Nielsen, Hans J.; Jakobsen, Karen V.; Christensen, Ib J.

2011-01-01

Emerging results indicate that screening improves survival of patients with colorectal cancer. Therefore, screening programs are already implemented or are being considered for implementation in Asia, Europe and North America. At present, a great variety of screening methods are available including...... into improvements of screening for colorectal cancer includes blood-based biological markers, such as proteins, DNA and RNA in combination with various demographically and clinically parameters into a "risk assessment evaluation" (RAE) test. It is assumed that such a test may lead to higher acceptance among...... procedures for colorectal cancer. Therefore, results of present research, validating RAE tests, are awaited with interest....

Environmental Factors and Colorectal Tumor Risk in Individuals With Hereditary Nonpolyposis Colorectal Cancer

NARCIS (Netherlands)

Diergaarde, B.; Braam, H.; Vasen, H.F.; Nagengast, F.M.; Muijen, van G.N.P.; Kok, F.J.; Kampman, E.

2007-01-01

Background & Aims: Individuals with hereditary nonpolyposis colorectal cancer (HNPCC) are at increased risk for colorectal cancer. Environmental factors might play a role in HNPCC-associated carcinogenesis. The aim of this study was to gain insight into the effects of environmental factors on

Hormone Replacement Therapy and Colorectal Cancer Incidence and Mortality in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

Science.gov (United States)

Symer, Matthew M; Wong, Natalie Z; Abelson, Jonathan S; Milsom, Jeffrey W; Yeo, Heather L

2018-06-01

Hormone replacement therapy has been shown to reduce colorectal cancer incidence, but its effect on colorectal cancer mortality is controversial. The objective of this study was to determine the effect of hormone replacement therapy on survival from colorectal cancer. We performed a secondary analysis of data from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, a large multicenter randomized trial run from 1993 to 2001, with follow-up data recently becoming mature. Participants were women aged 55 to 74 years, without recent colonoscopy. Data from the trial were analyzed to evaluate colorectal cancer incidence, disease-specific mortality, and all-cause mortality based on subjects' use of hormone replacement therapy at the time of randomization: never, current, or former users. A total of 75,587 women with 912 (1.21%) incident colorectal cancers and 239 associated deaths were analyzed, with median follow-up of 11.9 years. Overall, 88.6% were non-Hispanic white, and colorectal cancer incidence in current users compared to never-users was lower (hazard ratio [HR], 0.81; 95% confidence interval [CI], 0.69-0.94; P = .005), as was death from colorectal cancer (HR, 0.63; 95% CI, 0.47-0.85; P = .002) and all-cause mortality (HR, 0.76; 95% CI, 0.72-0.80; P colorectal cancer incidence and improved colorectal cancer-specific survival, as well as all-cause mortality. Copyright © 2018 Elsevier Inc. All rights reserved.

Intrabilary obstruction by colorectal metastases

OpenAIRE

Traeger, Luke; Kiroff, George

2018-01-01

Abstract Intrabiliary colorectal metastases are rare. We present a case of an 84-year-old man who developed obstructive jaundice secondary to intrabiliary growth of colorectal metastases. The patient presented with three weeks of jaundice and significant weight loss in the preceding months. The patient’s background included metastatic colorectal carcinoma, with a previous right hemicolectomy and left hepatectomy for liver metastases. A MRCP showed an obstruction of the biliary tract transitio...

Un orden urbano: Paisaje, calidad de vida y sustentabilidad

OpenAIRE

Hans Fox Timmling

2008-01-01

La calidad de vida regional representa entonces un conjunto de metas por medio de las cuales las sociedades se aseguran que las transformaciones territoriales y espaciales proporcionen una mejor existencia a sus habitantes, tanto de la sociedad como también la sustentabilidad de todos los procesos naturales que fundamentan la vida social en una región. Los Planes de Ordenamiento Territorial, ciertamente han de enmarcarse en esta meta más general de aumentar la calidad de vida regional y la su...

Toward standardizing and reporting colorectal cancer screening indicators on an international level: The International Colorectal Cancer Screening Network

NARCIS (Netherlands)

Benson, Victoria S.; Atkin, Wendy S.; Green, Jane; Nadel, Marion R.; Patnick, Julietta; Smith, Robert A.; Villain, Patricia; Patnick, J.; Atkin, W. S.; Altenhofen, L.; Ancelle-Park, R.; Benson, V. S.; Green, J.; Levin, T. R.; Moss, S. M.; Nadel, M.; Ransohoff, D.; Segnan, N.; Smith, R. A.; Villain, P.; Weller, D.; Koukari, A.; Young, G.; López-Kostner, F.; Antoljak, N.; Suchánek, S.; Zavoral, M.; Holten, I.; Malila, N.; Salines, E.; Brenner, G.; Herszényi, L.; Tulassay, Z.; Rennert, G.; Senore, C.; Zappa, M.; Zorzi, M.; Saito, H.; Leja, M.; Dekker, E.; Jansen, J.; Hol, L.; Kuipers, E.; Kaminski, M. F.; Regula, J.; Sfarti, C.; Trifan, A.; Tang, C.-L.; Hrcka, R.; Binefa, G.; Espinàs, J. A.; Peris, M.; Chen, T. H.; Steele, R.; Pou, G.; Bisges, D.; Dwyer, D.; Groves, C.; Courteau, S.; Kramer, R.; Siegenthaler, K.; Lane, D.; Herrera, C.; Rogers, J.; Rojewski, M.; Wolf, Holly; Sung, J. J.; Ling, K.; Bryant, H.; Rabeneck, L.; Dale, J.; Sware, L.; Yang, H.; Viguier, J.; Von Karsa, L.; Kupcinskas, L.; Deutekom, M.; Törnberg, S.; Austoker, J.; Beral, V.; Monk, C.; Valori, R.; Watson, J.; Kobrin, S.; Pignone, M.; Taplin, S.

2012-01-01

The International Colorectal Cancer Screening Network was established in 2003 to promote best practice in the delivery of organized colorectal cancer screening programs. To facilitate evaluation of such programs, we defined a set of universally applicable colorectal cancer screening measures and

Análise comparativa das PE e PI máximas entre mulheres grávidas e não-grávidas e entre grávidas de diferentes períodos gestacionais

Directory of Open Access Journals (Sweden)

Leila Graziele Dias de Almeida

2005-10-01

Full Text Available O propósito deste estudo foi de verificar as possíveis diferenças entre as pressões inspiratórias e expiratórias máxima de mulheres grávidas e não-grávidas, bem como entre grávidas de períodos gestacionais diferentes. Para obtenção das informações propostas, foi utilizado o aparelho manuvacuômetro MVD 500, Mhmicrohard Global Med, como instrumento aferidor das pressões expiratória e inspiratória máxima de gestantes e não-gestantes compreendidas dentro de um mesmo grupo etário. O critério utilizado para seleção de informantes desta pesquisa foi estar grávida para um dos grupos e não estar grávida para o outro, sendo as mesmas escolhidas aleatoriamente através de indicações de informantes. A abordagem das informantes foi realizada em suas residências onde foram coletados dados de pressão inspiratória e expiratória máximas para posteriormente serem organizados, processados, categorizados e finalmente obter-se as médias encontradas nos grupos da amostra da pesquisa. As médias de pressão inspiratória e expiratória máximas obtidas nos grupos das gestantes foram as seguintes: PEmax.= 51,3cm H20; e Pimax= 48,3 cm H20; já as médias encontradas no grupo das não-gestantes foram: PEmax = 73 cm H2O, Pimax= 69,2cm H2O. As gestantes pertencentes ao subgrupo do primeiro ao quinto mês apresentaram uma média de PE= 56 cm H2O, e de PI= 60 cm H2O, enquanto que as gestantes do subgrupo a partir do sexto mês apresentaram as médias de PE e Pi= 56 cm H2O e 43,2 cm H2O respectivamente. Os resultados obtidos forneceram subsídios para inferir que existem diferenças entre as pressões inspiratória e expiratória máximas entre grávidas e não-grávidas, bem como em grávidas de período gestacionais diferentes

Diagnostic Ultrasound in Colorectal Cancer

DEFF Research Database (Denmark)

Rafaelsen, Søren Rafael

2014-01-01

SUMMARYBackground and purpose Colorectal cancer is a common disease in Denmark with considerable morbidity and mortality. Although survival in recent years has improved, Denmark still has the lowest 5-year survival compared to the other Nordic countries. The treatment of patients depends on local...... the potential to contribute to the staging of colorectal cancer. The purpose of these studies was to determine the usefulness of ultrasound diagnostics in patients with colorectal cancer.The purpose of the TRUS studies was to compare staging of rectal carcinomas using digital rectal exploration...... of 295 patients with primary colorectal cancer we found a sensitivity of preoperative ultrasound, surgical exploration, and intraoperative ultrasound of 70%, 84%, and 97%, respectively, based on a patient-by-patient comparison (p

Calidad de vida de mujeres en postmenopausia. Valoración con “Menopause Rating Scale” de tres etnias colombianas diferentes

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Álvaro Monterrosa Castro

2009-08-01

Full Text Available Introducción. Pocos estudios han comparado el impacto del climaterio en la calidad de vida (CV en diferentes etnias latinoamericanas. Objetivo: Evaluar la CV en mujeres postmenopáusicas colombianas de tres etnias distintas. Material y método: Estudio descriptivo transversal que incluyó mujeres sanas entre 40 y 59 años de edad, pertenecientes a las etnias hispánicas, indígenas y negras. La población evaluada hace parte del Estudio Calidad de Vida en la Menopausia y Etnias Colombianas (Cavimec. El instrumento utilizado para valorar CV fue el Menopause Rating Scale. Resultados: Se estudiaron 579 mujeres postmenopáusicas, 153 hispánicas, 295 indígenas y 131 afrodescendientes. Las hispánicas tenían en promedio 55,3 (DE 3,3 años de edad, 6,4 (DE 3,5 años de escolaridad y habían presentado su menopausia a los 48,3 (DE 2,5 años. Comparadas con las hispánicas, las indígenas tenían una edad similar, menor escolaridad (2,2 [DE 1,8] años, p<0,0001 y mayor edad al inicio de su menopausia (49,5 [DE 3,0] años, p<0,0001. Las afrodescendientes eran más jóvenes que las hispánicas (53,4 [3,3] años, p<0,0001 y con menor escolaridad (4,6 [DE 4,4] años, p<0,0001. Las hispánicas tienen la mejor CV (MRS 8,6 [DE 5,7] puntos, seguidas por las afrodescendientes (13,7 [DE 7,0] puntos, p<0,001 y las indígenas (14,7 [DE 2,4] puntos, p<0,0001. Las afrodescendientes tienen un mayor deterioro psicológico (dimensión psicológica 5,9 [DE 2,9] puntos que las hispánicas (2,7 [DE 2,6] puntos, p<0,0001 o las indígenas (3,1 [DE 1,6] puntos, p<0,0001, y presentan más síntomas somáticos (dimensión somática 6,5 [DE 3,3] puntos, 4,6 [DE 2,9] puntos, y 5,3 [1,7] puntos, respectivamente; p<0,0001. Las indígenas presentan mayor sintomatología urogenital (dimensión urogenital 6,2 [DE 1,3] puntos que las hispánicas (1,3 [DE 2,3] puntos, p<0,0001 y las afrodescendientes (1,1 [DE 1,9] puntos, p<0,0001. Conclusión: Las mujeres postmenopáusicas hisp

Microbial and viral pathogens in colorectal cancer.

LENUS (Irish Health Repository)

Collins, Danielle

2011-05-01

The heterogenetic and sporadic nature of colorectal cancer has led to many epidemiological associations with causes of this disease. As our understanding of the underlying molecular processes in colorectal-cancer develops, the concept of microbial-epithelial interactions as an oncogenic trigger might provide a plausible hypothesis for the pathogenesis of colorectal cancer. By contrast with other cancers of the gastrointestinal tract (gastric carcinoma, mucosa-associated lymphoid-tissue lymphoma), a direct causal link between microbial infection (bacteria and viruses) and colorectal carcinoma has not been established. Studies support the involvement of these organisms in oncogenesis, however, in colorectal cancer, clinical data are lacking. Here, we discuss current evidence (both in vitro and clinical studies), and focus on a putative role for bacterial and viral pathogens as a cause of colorectal cancer.

Microbial and viral pathogens in colorectal cancer.

LENUS (Irish Health Repository)

Collins, Danielle

2012-02-01

The heterogenetic and sporadic nature of colorectal cancer has led to many epidemiological associations with causes of this disease. As our understanding of the underlying molecular processes in colorectal-cancer develops, the concept of microbial-epithelial interactions as an oncogenic trigger might provide a plausible hypothesis for the pathogenesis of colorectal cancer. By contrast with other cancers of the gastrointestinal tract (gastric carcinoma, mucosa-associated lymphoid-tissue lymphoma), a direct causal link between microbial infection (bacteria and viruses) and colorectal carcinoma has not been established. Studies support the involvement of these organisms in oncogenesis, however, in colorectal cancer, clinical data are lacking. Here, we discuss current evidence (both in vitro and clinical studies), and focus on a putative role for bacterial and viral pathogens as a cause of colorectal cancer.

Calidad de vida en supervivientes a largo plazo de cáncer de mama: Un área olvidada en la investigación enfermera española Quality of life in long-term breast cancer survivors: A neglected area in the spanish nursing research

Directory of Open Access Journals (Sweden)

Cristina G. Vivar

2005-11-01

Full Text Available El principal objetivo de este ensayo es evidenciar la importancia de fomentar estudios con supervivientes a largo plazo de cáncer de mama, al mismo tiempo que se introduce el concepto de supervivencia a largo plazo en el contexto de la investigación enfermera española. El cuerpo de este artículo se organiza en tres apartados que examinan estudios sobre la calidad de vida en mujeres supervivientes al cáncer de mama. Con esta revisión se demuestra que la calidad de vida de estas mujeres difiere de la de las mujeres sanas. Por lo tanto, se concluye que es importante promover la investigación en España en este ámbito de la enfermería oncológica con el fin de ofrecer una atención de calidad a esta población creciente.The main purpose of this paper is to evidence the importance of fostering research with long-term breast cancer survivors, at the same time that the concept of long-term survivorship is introduced in the Spanish nursing research context. This paper is organised into three sections that examine studies on the quality of life in survivors of breast cancer. Evidence shows that the quality of life of these women differ from that of healthy women. Therefore, it is concluded that it is important to promote research in this area of cancer nursing in Spain in order to provide good care to this growing population.

Colorectal Cancer Awareness for Women via Facebook: A Pilot Study.

Science.gov (United States)

Brittain, Kelly; Pennings Kamp, Kendra J; Salaysay, Zachary

Colorectal cancer is the third leading cause of cancer death among U.S. women. Women report being screened for colorectal cancer less often than men, and if colorectal cancer screening guidelines were routinely followed, approximately 60% of colorectal cancer deaths could be prevented. Many colorectal cancer screening interventions have not used Facebook, which is the most popular social media site among women. Little is known about engaging women in colorectal cancer screening and risk reduction information using Facebook. The "Colorectal Cancer Screening Awareness for Women" Facebook page was created to promote colorectal cancer screening and risk reduction awareness among women. Facebook posts targeted women aged 45-64 years and highlighted colorectal cancer screening methods, guidelines, and colorectal cancer risk reduction strategies. Demographics and data about the women's interactions with the page were collected using Facebook analytics and analyzed. The majority of the 391 users of the Colorectal Cancer Screening Awareness for Women Facebook page were women aged 45-54 years (56.5%). The most "liked" posts were related to colorectal cancer risk reduction behaviors. In an effort to increase routine colorectal cancer screening and colorectal cancer risk reduction behaviors, gastroenterology nurses and practices should consider Facebook as a good method to regularly engage women in colorectal cancer screening and colorectal cancer risk reduction information.

Modifiable risk factors and colorectal adenomas among those at high risk of colorectal cancer

NARCIS (Netherlands)

Botma, A.

2011-01-01

Epidemiological studies have identified several modifiable risk factors for colorectal neoplasms in the general population. However, associations between modifiable risk factors, including body mass index (BMI), smoking, alcohol consumption and dietary patterns, and colorectal neoplasms in two

Colorectal Cancer Rates by Race and Ethnicity

Science.gov (United States)

... Associated Lung Ovarian Prostate Skin Uterine Cancer Home Colorectal Cancer Rates by Race and Ethnicity Language: English (US) ... Tweet Share Compartir The rate of people getting colorectal cancer or dying from colorectal cancer varies by race ...

Synchronous colorectal liver metastases

NARCIS (Netherlands)

A.E.M. van der Pool (Anne)

2011-01-01

textabstractColorectal cancer is one of the most common malignancies worldwide and ranks second in cancer-related deaths in many parts of the Western world. Once in the lymph or blood vessels, colorectal cancer can quickly spread and the liver is known to be a favourable site for metastases. The

Calidad de vida

Directory of Open Access Journals (Sweden)

Enrique Ardila

2000-07-01

Full Text Available Muchas enfermedades tienen un impacto sobre las personas diferente de la mortalidad, como es el caso de las enfermedades no letales que producen sufrimiento e incapacidad. Debido a esto también es importante medir el impacto de las enfermedades en términos del efecto que estas tienen sobre la calidad de vida de la persona que las padece.

La conciliación de la vida laboral y familiar como proyecto de calidad de vida desde la igualdad

OpenAIRE

Papí Gálvez, Natalia

2005-01-01

Artículo inserto en dos proyectos subvencionados por el Instituto de la Mujer: «El género en el desarrollo socioeconómico. Los perfiles laborales y la calidad de vida: Un estudio dinámico», BOE 15/02/2001, y «La mujer en la empresa publicitaria. Políticas de conciliación de la vida familiar y laboral. En torno al techo de cristal», BOE 30/01/2004.

Impacto de la crisis en el derecho a una alimentación sana y saludable. Informe SESPAS 2014

Directory of Open Access Journals (Sweden)

Josep Maria Antentas

2014-06-01

Full Text Available El artículo analiza el impacto de la crisis en los hábitos alimentarios de la población española, a qué perfiles sociales afecta y qué consecuencias tiene para la salud, basándose en informes oficiales y en la revisión de estudios empíricos. La crisis tiene consecuencias en la alimentación y modifica el comportamiento alimentario. Las familias buscan ahorrar en alimentación. Aumenta la inseguridad alimentaria y los grupos más proclives a verse sumidos en ella son aquellos que dedican una mayor proporción de sus ingresos a la comida. El recorte en el gasto alimentario va acompañado también de hábitos alimentarios poco saludables que favorecen la obesidad. En consecuencia, puede afirmarse que la crisis contribuye a la vulneración del derecho a una alimentación sana y saludable reconocido por el Pacto Internacional para los Derechos Económicos Sociales y Culturales de las Naciones Unidas.

Danish Colorectal Cancer Group Database

DEFF Research Database (Denmark)

Ingeholm, Peter; Gögenur, Ismail; Iversen, Lene H

2016-01-01

AIM OF DATABASE: The aim of the database, which has existed for registration of all patients with colorectal cancer in Denmark since 2001, is to improve the prognosis for this patient group. STUDY POPULATION: All Danish patients with newly diagnosed colorectal cancer who are either diagnosed......, and other pathological risk factors. DESCRIPTIVE DATA: The database has had >95% completeness in including patients with colorectal adenocarcinoma with >54,000 patients registered so far with approximately one-third rectal cancers and two-third colon cancers and an overrepresentation of men among rectal...... diagnosis, surgical interventions, and short-term outcomes. The database does not have high-resolution oncological data and does not register recurrences after primary surgery. The Danish Colorectal Cancer Group provides high-quality data and has been documenting an increase in short- and long...

Colorectal cancer screening

OpenAIRE

Plumb, A. A.; Halligan, S.

2015-01-01

Colorectal cancer is a major public health burden worldwide. There is clear-cut evidence that screening will reduce colorectal cancer mortality and the only contentious issue is which screening tool to use. Most evidence points towards screening with fecal occult blood testing. The immunochemical fecal occult blood tests have a higher sensitivity than the guaiac-based tests. In addition, their automation and haemoglobin quantification allows a threshold for colonoscopy to be selected that can...

6 Common Cancers - Colorectal Cancer

Science.gov (United States)

... Home Current Issue Past Issues 6 Common Cancers - Colorectal Cancer Past Issues / Spring 2007 Table of Contents For ... of colon cancer. Photo: AP Photo/Ron Edmonds Colorectal Cancer Cancer of the colon (large intestine) or rectum ( ...

Colorectal Cancer Risk Assessment Tool

Science.gov (United States)

... 11/12/2014 Risk Calculator About the Tool Colorectal Cancer Risk Factors Download SAS and Gauss Code Page ... Rectal Cancer: Prevention, Genetics, Causes Tests to Detect Colorectal Cancer and Polyps Cancer Risk Prediction Resources Update November ...

Bone morphogenetic protein signalling in colorectal cancer

NARCIS (Netherlands)

Hardwick, James C.; Kodach, Liudmila L.; Offerhaus, G. Johan; van den Brink, Gijs R.

2008-01-01

Much of the current understanding of colorectal cancer stems from the study of rare, inherited colorectal cancer syndromes. Mutations in the bone morphogenetic protein (BMP) pathway have been found in juvenile polyposis, an inherited polyposis syndrome that predisposes to colorectal cancer. The

Brain metastasis from colorectal cancer

International Nuclear Information System (INIS)

Bamba, Yoshiko; Itabashi, Michio; Hirosawa, Tomoichiro; Ogawa, Shinpei; Noguchi, Eiichiro; Takemoto, Kaori; Shirotani, Noriyasu; Kameoka, Shingo

2007-01-01

The present study was performed to clarify the clinical characteristics of brain metastasis from colorectal cancer. Five patients with brain metastasis from colorectal cancer treated at our institute between 2001 and 2005 were included in the study. Clinical findings and survival time were determined and an appropriate system for follow-up in such cases was considered. Brain metastasis was found after surgery for colorectal cancer in 4 cases. In addition, colorectal cancer was found after diagnosis of brain metastasis in 1 case. At the time of diagnosis of brain metastasis, all patients had lung metastasis and 3 had liver metastasis. The mean periods between surgery for colorectal cancer and lung and brain metastases were 19.5 and 38.2 months, respectively. In all cases, brain metastasis was diagnosed by imaging after the appearance of neurological symptoms. Brain metastases were multiple in 1 case and focal in 4 cases. We performed gamma knife radiation therapy, and the symptoms disappeared or decreased in all cases. Mean survival time after brain metastasis was 3.0 months. Prognosis after brain metastasis is poor, but gamma knife radiation therapy contributed to patients' quality of life. (author)

Calidad de vida en adultos del Paraguay con enfermedad celiaca

Directory of Open Access Journals (Sweden)

Raúl Emilio Real-Delor

2018-01-01

Full Text Available La enfermedad celiaca altera el estado emocional, las relaciones sociales, la autonomía y la percepción de la salud, afectando la calidad de vida relacionada a la salud. Los objetivos fueron determinar la calidad de vida relacionada a la salud en adolescentes y adultos con enfermedad celiaca e investigar los factores que la afectan. Se realizó un estudio observacional, prospectivo, realizado en adolescentes y adultos del Paraguay portadores de enfermedad celiaca con al menos 6 meses en dieta sin gluten. Se aplicó el cuestionario CD-QOL. Fueron incluidos 114 sujetos, con edad media 30±10 años, siendo 58% del sexo femenino. La calidad de vida fue buena en 25%, regular en 49% y mala en 26%. Los factores asociados significativamente a mejor calidad de vida fueron el sexo femenino, el grupo etario >30 años y realizar actividades fuera del hogar. Se concluye que la calidad de vida de los celiacos adolescentes y adultos es regular en 49% de los encuestados.

Meat and colo-rectal cancer.

Science.gov (United States)

Hill, M J

1999-05-01

In early epidemiological studies of diet and cancer the stress was on the search for causal factors. Population (ecological) studies tended to show a strong correlation between meat intake, particularly red meat, and the risk of colo-rectal cancer. They also tended to show meat to be strongly inversely correlated with cancers of the stomach and oesophagus and liver. Early case-control studies tended to support the postulated role for red meat in colo-rectal carcinogenesis, although more recent case-control studies, particularly those from Europe, have tended to show no relationship. The cohort studies in general failed to detect any relationship between meat intake and colo-rectal cancer risk. The available evidence points to the intake of protective factors such as vegetables and whole-grain cereals being the main determinants of colo-rectal cancer risk, with meat intake only coincidentally related.

Social media in colorectal surgery.

Science.gov (United States)

Wexner, S D; Petrucci, A M; Brady, R R; Ennis-O'Connor, M; Fitzgerald, J E; Mayol, J

2017-02-01

The engagement of social media in healthcare continues to expand. For members of the colorectal community, social media has already made a significant impact on practice, education and patient care. The applications are unique such that they provide a platform for instant communication and information sharing with other users worldwide. The purpose of this article is to provide an overview of how social media has the potential to change clinical practice, training, research and patient care in colorectal surgery. Colorectal Disease © 2016 The Association of Coloproctology of Great Britain and Ireland.

Colorectal Cancer—Health Professional Version

Science.gov (United States)

Colorectal cancer studies often consider colon and rectal cancer together. Worldwide, colorectal cancer is the third most common form of cancer. Find evidence-based information on colon and rectal cancer treatment, causes and prevention, screening, research, genetics, and statistics.

Atrial fibrillation and survival in colorectal cancer

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Justin Timothy A

2004-11-01

Full Text Available Abstract Background Survival in colorectal cancer may correlate with the degree of systemic inflammatory response to the tumour. Atrial fibrillation may be regarded as an inflammatory complication. We aimed to determine if atrial fibrillation is a prognostic factor in colorectal cancer. Patients and methods A prospective colorectal cancer patient database was cross-referenced with the hospital clinical-coding database to identify patients who had underwent colorectal cancer surgery and were in atrial fibrillation pre- or postoperatively. Results A total of 175 patients underwent surgery for colorectal cancer over a two-year period. Of these, 13 patients had atrial fibrillation pre- or postoperatively. Atrial fibrillation correlated with worse two-year survival (p = 0.04; log-rank test. However, in a Cox regression analysis, atrial fibrillation was not significantly associated with survival. Conclusion The presence or development of atrial fibrillation in patients undergoing surgery for colorectal cancer is associated with worse overall survival, however it was not found to be an independent factor in multivariate analysis.

Qualidade de vida de adolescentes modelos profissionais

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Luciana Pires

Full Text Available Muitas adolescentes deixam suas famílias para seguir a profissão de modelo, sonhando com um futuro glamoroso. O presente estudo caso-controle analisou a qualidade de vida de 74 adolescentes do sexo feminino, sendo 37 modelos, agenciadas em São Paulo, com delineamento transversal, utilizando o World Health Organization Quality of Life - versão breve (WHOQOL-BREF, que avalia qualidade de vida global e os domínios físico, psicológico, social e ambiental. Utilizou-se o Critério Brasil 2008, para avaliação do nível socioeconômico e para parear o grupo controle. Em geral, o grupo de modelos obteve médias superiores ao grupo de não modelos, sendo esta diferença significante apenas no domínio psicológico. Observou-se que as adolescentes modelos apresentaram uma qualidade de vida semelhante à das não modelos.

Robotic colorectal surgery: hype or new hope? A systematic review of robotics in colorectal surgery.

Science.gov (United States)

Mirnezami, A H; Mirnezami, R; Venkatasubramaniam, A K; Chandrakumaran, K; Cecil, T D; Moran, B J

2010-11-01

Robotic colorectal surgery is an emerging field and may offer a solution to some of the difficulties inherent to conventional laparoscopic surgery. The aim of this review is to provide a comprehensive and critical analysis of the available literature on the use of robotic technology in colorectal surgery. Studies reporting outcomes of robotic colorectal surgery were identified by systematic searches of electronic databases. Outcomes examined included operating time, length of stay, blood loss, complications, cost, oncological outcome, and conversion rates. Seventeen Studies (nine case series, seven comparative studies, one randomized controlled trial) describing 288 procedures were identified and reviewed. Study heterogeneity precluded a meta-analysis of the data. Robotic procedures tend to take longer and cost more, but may reduce the length of stay, blood loss, and conversion rates. Complication profiles and short-term oncological outcomes are similar to laparoscopic surgery. Robotic colorectal surgery is a promising field and may provide a powerful additional tool for optimal management of more challenging pathology, including rectal cancer. Further studies are required to better define its role. © 2010 The Authors. Colorectal Disease © 2010 The Association of Coloproctology of Great Britain and Ireland.

Qualidade de vida: abordagens, conceitos e avaliação Calidad de vida: abordajes, conceptos y evaluaciíon Quality of life: approaches, concepts and assessment

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Érico Felden Pereira

2012-06-01

Full Text Available Apesar da grande relevância social, o tema qualidade de vida apresenta imprecisões teórico/metodológicas o que dificulta a investigação, o diálogo entre as diferentes áreas que trabalham com o tema e, principalmente, a aplicação do conhecimento produzido na melhoria da qualidade de vida da população. Buscando contribuir para a clarificação do conceito este estudo teve como objetivo, a partir da leitura, discussão e análise da literatura especializada, apresentar as principais abordagens, conceitos e propostas de classificação e avaliação da qualidade de vida. Verificou-se que as abordagens e conceitualizações sobre a qualidade de vida se apresentam na literatura de forma diversificada, e, por vezes, divergentes. A falta de consenso teórico leva muitas pesquisas a utilizarem conceitos como saúde, bem estar e estilo de vida como sinônimos de qualidade de vida. Novas abordagens epistemológicas no estudo do tema são necessárias bem como estudos que analisem a qualidade de vida em situações de intervenção.A pesar de la gran relevancia social, el tema calidad de vida presenta imprecisiones teórico/metodológicas, rasgo que dificulta la investigación, el diálogo entre las diferentes áreas que trabajan con el tema, principalmente, en la aplicación del conocimiento producido para mejorar la calidad de vida de la población. En la búsqueda para contribuir para aclarar el concepto, este estudio tuvo como objetivo, a partir de la lectura, discusión y análisis de la literatura especializada, presentar los principales abordajes, conceptos y propuestas de clasificación y evaluación de la calidad de vida. Se observó que los abordajes y conceptos sobre la calidad de vida se presentan en la literatura de forma diversificada y, por veces, divergentes. La falta de consenso teórico lleva muchas pesquisas a utilizaren conceptos como salud, bienestar y estilo de vida como sinónimos para calidad de vida. Nuevos abordajes

Tu proyecto de vida

OpenAIRE

Ramos, Georgina

2012-01-01

- Párrafo Inicial - Conociendo a Liliana N. - La intervención de la psicóloga Adriana - Tu proyecto de vida - Referencias - Notas de enseñanza o Resumen o Objetivos o Temas relacionados o Plan de aplicación para el aprendizaje o Análisis o Epílogo

Historias de vida

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BERNABÉ SARABIA

1985-01-01

Full Text Available El material biográfico tiene aplicaciones variadas, como los análisis de cohortes y ciclos vitales y los estudios profundos de casos individuales. Se revisa la bibliografía actual más importante sobre esta técnica de historias de vida, el modelo de reconstrucción autobiográfico y el método de Bruselas de autobiografía asistida.

El mito de la vida verdadera en la «Vida secreta» de Salvador Dalí

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Domingo Ródenas de Moya

2012-12-01

Full Text Available Este artículo se propone examinar cómo el mito de la mutatio vitae fue adoptado por Dalí como matriz narrativa de su autobiografía Vida secreta. Se sitúa el libro en el género del autorretrato que cultivó el pintor desde su juventud y en la tradición de las “vidas” ejemplares. La necesidad de reinventarse ante la sociedad norteamericana condujo a Dalí a identificar la cultura europea, en especial el arte de vanguardia, con la decadencia y la corrupción, en tanto él construía para sí mismo una coraza protectora con la firma de “salvador” del arte clásico. El crecimiento de esa coraza (o personaje público está narrado como el resultado de una revelación que da paso a una vida auténtica. En el relato de ese proceso, Gala aparece como el agente epifánico que cura al artista enfermo y redime al Dalí hombre. Vida secreta constituye una muestra excelente de autobiografía estetizada y supeditada a un objetivo: la configuración de una máscara pública que fuera a la vez marca registrada y coraza protectora. This paper aims to analyze how the myth of the mutatio vitae was adopted by Dalí as a narrative pattern in his autobiography Vida secreta. The book belongs to the genre of the self-portrait that he cultivated since his youth and it can also be considered part of the tradition of the “exemplary lives”. The need to reinvent himself in the eyes of American society brought Dalí to identify European culture, especially the art of avant-garde, with decadence and corruption, while he created for himself a protective cuirass, as the “salvador” of classical art. How he created this mask (or public figure is narrated as the result of a revelation which gives way to an authentic life. In the story of that process, Gala appears as the epiphanic agent who heals the sick artist and redeems Dalí, the man. Vida secreta is an excellent example of an aestheticised autobiography, subordinated to an object: setting a public mask

Años de esperanza de vida perdidos en Argentina, 2001-2010

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Leandro M. González

2012-07-01

Full Text Available En este artículo se indaga acerca de la evolución de la mortalidad Argentina con posterioridad a la crisis socioeconómica de fines del año 2001. También, se construyen tablas de vida a partir de proyecciones demográficas y registros de estadísticas vitales, y se describe la evolución de la esperanza de vida de cada sexo y se aplica el método de años de esperanza vida perdidos para analizar el cambio de la mortalidad. Al respecto, se encuentra que a lo largo de la década la población masculina avanza más que la femenina en términos de esperanza de vida, aunque la sobremortalidad masculina continúa siendo marcada. La crisis socioeconómica produjo una leve disminución de la esperanza de vida en el año 2002, y se recuperó rápidamente hasta 2005; entre 2006-08 se produce un descenso transitorio y vuelve a crecer de manera continua. Los años de esperanza de vida perdidos muestran que en el sexo masculino las defunciones externas producen la mayor pérdida de esperanza de vida, mientras que en las mujeres la principal causa son los tumores. Asimismo, se registra un incremento de la mortalidad debida a enfermedades del aparato respiratorio.

Años de esperanza de vida perdidos en Argentina, 2001-2010

Directory of Open Access Journals (Sweden)

Leandro M. González

2012-01-01

Full Text Available En este artículo se indaga acerca de la evolución de la mortalidad Argentina con posterioridad a la crisis socioeconómica de fines del año 2001. También, se construyen tablas de vida a partir de proyecciones demográficas y registros de estadísticas vitales, y se describe la evolución de la esperanza de vida de cada sexo y se aplica el método de años de esperanza vida perdidos para analizar el cambio de la mortalidad. Al respecto, se encuentra que a lo largo de la década la población masculina avanza más que la femenina en términos de esperanza de vida, aunque la sobremortalidad masculina continúa siendo marcada. La crisis socioeconómica produjo una leve disminución de la esperanza de vida en el año 2002, y se recuperó rápidamente hasta 2005; entre 2006-08 se produce un descenso transitorio y vuelve a crecer de manera continua. Los años de esperanza de vida perdidos muestran que en el sexo masculino las defunciones externas producen la mayor pérdida de esperanza de vida, mientras que en las mujeres la principal causa son los tumores. Asimismo, se registra un incremento de la mortalidad debida a enfermedades del aparato respiratorio.

Estilo de vida saudável em São Paulo, Brasil

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Tatiane Kosimenko Ferrari

Full Text Available Resumo: O objetivo foi analisar o estilo de vida das populações adolescente, adulta e idosa do Município de São Paulo, Brasil, de acordo com variáveis demográficas e socioeconômicas. Foi realizado estudo transversal, de base populacional, com dados do Inquérito de Saúde no Município de São Paulo (ISA-Capital 2008. O estilo de vida foi definido pela avaliação da atividade física, consumo alimentar, tabagismo, consumo abusivo e dependência de álcool, de acordo com as respectivas recomendações. A prevalência de estilo de vida saudável foi de 36,9% entre idosos, 15,4% entre adultos e 9,8% entre adolescentes, sendo maior no sexo feminino entre idosos e adultos. Dentre aqueles com estilo de vida não saudável, 51,5% dos idosos, 32,2% dos adultos e 57,9% dos adolescentes não atingiram a recomendação para uma dieta adequada. A prevalência de estilo de vida saudável foi maior entre idosos, seguida pelos adultos e adolescentes. O consumo alimentar foi o principal responsável pelo estilo de vida não saudável, evidenciando a importância de intervenções para a promoção do estilo de vida saudável e, principalmente, da dieta adequada.

Outreach training model for accredited colorectal specialists in laparoscopic colorectal surgery: feasibility and evaluation of challenges.

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Hamdan, M F; Day, A; Millar, J; Carter, F J C; Coleman, M G; Francis, N K

2015-07-01

The aim of this study was to explore the feasibility and safety of an outreach model of laparoscopic colorectal training of accredited specialists in advanced laparoscopic techniques and to explore the challenges of this model from the perspective of a National Training Programme (NTP) trainer. Prospective data were collected for unselected laparoscopic colorectal training procedures performed by five laparoscopic colorectal NTP trainees supervised by a single NTP trainer with an outreach model between 2009 and 2012. The operative and postoperative outcomes were compared with standard laparoscopic colorectal training procedures performed by six senior colorectal trainees under the supervision of the same NTP trainer within the same study period. The primary outcome was 30-day mortality. The Mann-Whitney test was used to compare continuous variables and the Chi squared or Fisher's exact tests were applied for the analysis of categorical variables. The level of statistical significance was set at P groups. Seventy-eight per cent of the patients operated on by the NTP trainees had had no previous abdominal surgery, compared with 50% in the supervised trainees' group (P = 0.0005). There were no significant differences in 30-day mortality or the operative and postoperative outcome between both groups. There were, however, difficulties in training an already established consultant in his or her own hospital and these were overcome by certain adjustments to the programme. Outreach laparoscopic training of colorectal surgeons is a feasible and safe model of training accredited specialists and does not compromise patient care. The challenges encountered can be overcome with optimum training and preparation. Colorectal Disease © 2015 The Association of Coloproctology of Great Britain and Ireland.

¿Una alimentación sana puede prevenir el cáncer?

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Boticario, Consuelo

2004-01-01

El cáncer es una enfermedad tan antigua en nuestro planeta como la vida. Prueba de ello son los tumores encontrados en los huesos de fósiles de dinosaurios o en las momias humanas descubiertas en Perú y Egipto. Documentos que datan del 2000 al 1500 a.c., como el Ramayana de la India o el Papiro Ebers de Egipto, hacen referencia a este padecimiento. Su nombre, cáncer, se inspiró en la observación de los tumores de mama que, al crecer, toman la forma de un cangrejo.

Oestrogen receptor beta isoform expression in sporadic colorectal cancer, familial adenomatous polyposis and progressive stages of colorectal cancer.

Science.gov (United States)

Stevanato Filho, Paulo Roberto; Aguiar Júnior, Samuel; Begnami, Maria Dirlei; Kuasne, Hellen; Spencer, Ranyell Matheus; Nakagawa, Wilson Toshihiko; Bezerra, Tiago Santoro; Kupper, Bruna Catin; Takahashi, Renata Maymi; Barros Filho, Mateus; Rogatto, Silvia Regina; Lopes, Ademar

2017-11-13

Among the sex hormones, oestrogen may play a role in colorectal cancer, particularly in conjunction with oestrogen receptor-β (ERβ). The expression of ERβ isoform variants and their correlations with familial adenomatous polyposis (FAP) syndrome and sporadic colorectal carcinomas are poorly described. This study aimed to investigate the expression levels of the ERβ1, ERβ2, ERβ4 and ERβ5 isoform variants using quantitative RT-PCR (921 analyses) in FAP, normal mucosa, adenomatous polyps and sporadic colorectal carcinomas. Decreased expression of ERβ isoforms was identified in sporadic polyps and in sporadic colorectal cancer as well as in polyps from FAP syndrome patients compared with normal tissues (p colorectal carcinomas were compared to normal mucosa tissues. These findings suggest an association of the ERβ isoform variants in individuals affected by germline mutations of the APC gene. Progressively decreased expression of ERβ was found in polyps at early stages of low-grade dysplasia, followed by T1-T2 and T3-T4 tumours (p colorectal cancer, the loss of expression was an independent predictor of recurrence, and ERβ1 and ERβ5 expression levels were associated with better disease-free survival (p = 0.002). These findings may provide a better understanding of oestrogens and their potential preventive and therapeutic effects on sporadic colorectal cancer and cancers associated with FAP syndrome.

Management of colorectal cancer and diabetes

OpenAIRE

Yao, Caroline; Nash, Guy F; Hickish, Tamas

2014-01-01

Colorectal cancer is associated with diabetes mellitus and both of these common conditions are often managed together by a surgeon. The surgical focus is usually upon cancer treatment rather than diabetes management. The relationship between colorectal cancer and diabetes is a complex one and can raise problems in both diagnosis and the management of patients with both conditions. This literature review explores the relationship between diabetes, diabetic treatment and colorectal cancer and a...

NARRATIVAS DE JOVENES TRAPECISTAS SOBRE SU MUNDO DE LA VIDA COMO UNA ORIENTACIÓN DIDÁCTICA PARA LA ENSEÑANZA DEL CONCEPTO VIDA DESDE LA BIOLOGÍA.

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Susam Paola Laverde Sánchez

2014-05-01

Full Text Available Hablar de la vida y lo vivo en el contexto contemporáneo denota un panorama complejo. Enseñar la vida y lo vivo desde la biología, sugiere ampliar los límites globales que establecen unas metas educativas, en cumplimiento a un currículo orientado a través de unos estándares educativos planteados de manera homogenizante. Sin demeritar dichos fines educativos, es primordial entender que la vida y lo vivo se aprende y se vivencia en contexto; que somos seres vivos, biológicos y humanos supeditados a nuestras maneras de comprender la vida misma; y el porqué es esencial reconocerla y narrarla, más aún cuando deseamos que nuestra práctica docente incida en la vida de otros y otras, en su transformación individual y colectiva.    Es así que, para este proceso investigativo cambia el propósito educativo: se aborda la vida y lo vivo desde el contexto propio y la experiencia de vida donde, a través de la narrativa como una metodología de investigación cualitativa, se reconocen, leen, transcriben y construyen las comprensiones y expresiones de 50 jóvenes en situación de vulnerabilidad, que hacen parte del Instituto para la Protección de la Niñez y la Juventud (IDIPRON, sede UPI santa Lucia, ubicada en la ciudad de Bogotá, Colombia. Con el ánimo de que estas narrativas se constituyan en una orientación didáctica para  la enseñanza del concepto vida, desde la biología en contexto. Es una propuesta alterna a las maneras tradicionales de abordar la vida y lo vivo desde la enseñanza de la biología, en vista de los múltiples contextos de trabajo donde vivenciamos la labor docente, prácticas que deben trascender.

The dutch surgical colorectal audit

NARCIS (Netherlands)

Leersum, N.J. van; Snijders, H.S.; Henneman, D.; Kolfschoten, N.E.; Gooiker, G.A.; Berge, M.G. Ten; Eddes, E.H.; Wouters, M.W.; Tollenaar, R.A.E.M.; Bemelman, W.A.; Dam, R.M. van; Elferink, M.A.; Karsten, T.M.; Krieken, J.H. van; Lemmens, V.E.; Rutten, H.J.; Manusama, E.R.; Velde, C.J. van de; Meijerink, W.J.H.J.; Wiggers, T.; Harst, E. van der; Dekker, J.W.T.; Boerma, D.

2013-01-01

INTRODUCTION: In 2009, the nationwide Dutch Surgical Colorectal Audit (DSCA) was initiated by the Association of Surgeons of the Netherlands (ASN) to monitor, evaluate and improve colorectal cancer care. The DSCA is currently widely used as a blueprint for the initiation of other audits, coordinated

Programa de educación emocional para la prevención de la violencia en las relaciones adolescentes

OpenAIRE

Gómez González, Graciela

2014-01-01

La adolescencia forma parte del desarrollo evolutivo del ser humano, considerándose una etapa de transición a la vida adulta, acompañada de unos cambios físicos, sociales y de personalidad. En esta etapa es muy importante que el individuo tenga definido su identidad y posea una buena imagen de sí mismo, acompañado de una autoestima positiva, para que vivan unas relaciones sanas en general, porque de lo contrario puede verse sometido a situaciones de maltrato psicológico. [...] Grado en Edu...

Análisis del consumidor fitness de la ciudad de Medellín

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Henao Ortega, Erica Susana; Vásquez Vélez, Susana

2016-01-01

El auge de estilos de vida como el Fitness se caracteriza por un alto consumo de productos y servicios, como suplementos dietarios y entrenamiento físico que va desde gimnasios y exigencias de alto rendimiento hasta nuevas tendencias de actividad física al aire libre y nutrición sana, entre otras posibilidades, todo ello acompañado de aspectos que mejoran la motivación y la disciplina y que pueden involucrar un cambio no solo en la forma en que las personas perciben y sienten su cuerpo intern...

Colorectal cancer screening

OpenAIRE

McLoughlin, Monica Ramona

2008-01-01

Colorectal cancer is a major public health burden and is the most common cause of mortality from cancer in Europe. Over the last two decades robust evidence from randomised clinical trials and case-control series have confirmed that the mortality from colorectal cancer can be reduced by screening. The challenge over the next decade is how to implement this in clinical practice. This is what we set out to answer with this thesis. Not all individuals are equal when it comes to screening and tho...

Reduction in Late Diagnosis of Colorectal Cancer Following Introduction of a Specialist Colorectal Surgery Service

Science.gov (United States)

Thorne, Amanda L; Mercer, Stuart J; Harris, Guy JC; Simson, Jay NL

2006-01-01

INTRODUCTION An audit of patients presenting with colorectal cancer to our district general hospital during a 2-year period from November 1994 found that 12.1% of cases were diagnosed later than 6 months after initial presentation to a physician. This audit was repeated for a 2-year period from December 2001, to determine whether the introduction of a specialist coloproctology surgery service had led to a reduction in late diagnosis of colorectal cancer. PATIENTS AND METHODS Case notes were reviewed of all patients presenting with colorectal cancer between December 2001 and November 2003. Late diagnosis was defined as diagnosis of colorectal cancer more than 6 months after their first attendance to either their general practitioner or district general hospital. The results were compared with those of the previous study. RESULTS Of a total of 218 patients presenting with colorectal cancer during the study period, 14 (6.4%; 10 men and 4 women) satisfied the criteria for late diagnosis, with the longest delay being 12.5 months. Reasons for late diagnosis were false-negative reporting of barium studies (n = 3), inaccurate tumour biopsy (n = 2), concurrent pathology causing anaemia (n = 4), inappropriate delay in definitive investigation (n = 3), and refusal of investigation by patients (n = 2). CONCLUSIONS There has been a reduction of nearly 50% (12.1% to 6.4%) in the proportion of patients with a late diagnosis of colorectal cancer compared with our previous audit. It is suggested that an important factor in this improvement in diagnosis has been the introduction of a specialist coloproctology surgery service. PMID:17059718

QUALIDADE DE VIDA DE IDOSOS COM MOBILIDADE FÍSICA PREJUDICADA

OpenAIRE

Juliana Maria de Paula; Namie Okino Sawada; Adriana Cristina Nicolussi; Cristiane Thomaz de Aquino Exel Andrade; Viviane Andrade

2013-01-01

Se trata de una revisión integradora, con objetivo de identificar evidencias disponibles acerca del conocimiento sobre calidad de vida de ancianos con movilidad física perjudicada, entre 2001 y 2011. Los datos fueron recolectados en las bases de datos LILACS, MEDLINE y Cochrane. Después de lectura analítica de las obras, se seleccionaron 16 artículos para análisis en dos categorías temáticas: calidad de vida y satisfacción personal, y calidad de vida y capacidad funcional. Limitaciones de la ...

The Dutch surgical colorectal audit

NARCIS (Netherlands)

van Leersum, N. J.; Snijders, H. S.; Henneman, D.; Kolfschoten, N. E.; Gooiker, G. A.; ten Berge, M. G.; Eddes, E. H.; Wouters, M. W. J. M.; Tollenaar, R. A. E. M.; Bemelman, W. A.; van Dam, R. M.; Elferink, M. A.; Karsten, Th M.; van Krieken, J. H. J. M.; Lemmens, V. E. P. P.; Rutten, H. J. T.; Manusama, E. R.; van de Velde, C. J. H.; Meijerink, W. J. H. J.; Wiggers, Th; van der Harst, E.; Dekker, J. W. T.; Boerma, D.

2013-01-01

In 2009, the nationwide Dutch Surgical Colorectal Audit (DSCA) was initiated by the Association of Surgeons of the Netherlands (ASN) to monitor, evaluate and improve colorectal cancer care. The DSCA is currently widely used as a blueprint for the initiation of other audits, coordinated by the Dutch

Internal hernia following laparoscopic colorectal surgery

DEFF Research Database (Denmark)

Svraka, Melina; Wilhelmsen, Michał; Bulut, Orhan

2017-01-01

Although internal hernias are rare complications of laparoscopic colorectal surgery, they can lead to serious outcomes and are associated with a high mortality of up 20 %. AIM OF THE STUDY: The aim of this study was to describe our experience regarding internal herniation following laparoscopic...... colorectal surgery. MATERIALS AND METHODS: From 2009 to 2015, more than 1,093 laparoscopic colorectal procedures were performed, and 6 patients developed internal herniation. Data were obtained from patients' charts and reviewed retrospectively. Perioperative course and outcomes were analyzed. RESULTS: All...... patients were previously operated due to colorectal cancer. Two patients presented with ischemia at laparotomy, and 2 had endoscopic examinations before surgery. One patient was diagnosed with cancer on screening colonoscopy. One patient died after laparotomy. CONCLUSION: Internal herniation that develops...

Extracting gravity wave parameters during the September 2002 Southern Hemisphere major sudden stratospheric warming using a SANAE imaging riometer

Energy Technology Data Exchange (ETDEWEB)

Mbatha, N. [South African National Space Agency, Hermanus (South Africa). Space Science; KwaZulu-Natal Univ., Durban (South Africa). School of Chemistry and Physics; Sivakumar, V. [KwaZulu-Natal Univ., Durban (South Africa). School of Chemistry and Physics; Bencherif, H. [La Reunion Univ. UMR 8105 CNRS, Saint-Denis (France). Lab. de l' Atmosphere et des Cyclones; Malinga, S. [South African National Space Agency, Hermanus (South Africa). Space Science

2013-11-01

Using absorption data measured by imaging riometer for ionospheric studies (IRIS) located at the South Africa National Antarctic Expedition (SANAE), Antarctica (72 S, 3 W), we extracted the parameters of gravity waves (GW) of periods between 40 and 50 min during late winter/ spring of the year 2002, a period of the unprecedented major sudden stratospheric warming (SSW) in the Southern Hemisphere middle atmosphere. During this period, an unprecedented substantial increase of temperature by about 25-30K throughout the stratosphere was observed. During the period of the occurrence of the major stratospheric warming, there was a reduction of both the GW horizontal phase speeds and the horizontal wavelengths at 90 km. The GW phase speeds and horizontal wavelengths were observed to reach minimum values of about 7ms{sup -1} and 19 km, respectively, while during the quiet period the average value of the phase speed and horizontal wavelength was approximately 23ms{sup -1} and 62 km, respectively. The observed event is discussed in terms of momentum flux and also a potential interaction of gravity waves, planetary waves and mean circulation.

Obesity and colorectal cancer risk

International Nuclear Information System (INIS)

Hano Garcia, Olga Marina; Wood Rodriguez, Lisette; Villa Jimenez, Oscar Manuel

2011-01-01

Obesity is a chronic and multifactor disease characterized by presence of excess body fat harmful for health. Several studies have been conducted to assess the possible risk character of different factors for colorectal cancer including the following modifying factors: a diet rich in saturated fats, a diet low in vegetables, physical inactivity, alcohol consumption and obesity. A case-control study was conducted to include 276 adult patients (93 cases and 184 controls) consecutively seen from May, 2008 to May, 2009 in the Institute of Gastroenterology determining a possible association between obesity as risk factor and colorectal cancer. Variables measures included: sex, age, skin color, body mass index, hip-waist circumference and endoscopic location of cancer. We conclude that the colorectal cancer with predominance in female sex and in white people in both groups. Obesity according to a great relation hip-waist had an strong relation with colorectal cancer, which had predominance towards distal colon in both sexes

El dominio sobre lo cotidiano: la búsqueda de la calidad de vida

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JUAN CARLOS DE PABLOS

1999-01-01

Full Text Available En este trabajo se analiza la materialización de la calidad de vida como uno de los valores dominantes en las sociedades postmaterialistas: qué la produce en la vida cotidiana, qué se hace para lograrla. Partiendo de als distinciones clásicas en el concepto de calidad de vida (elementos objetivos y satisfacción subjetiva ; equilibrio y riqueza, se plantean otros componentes en la búsqueda habitual de la calidad de vida. Ésta se hace efectiva a través del consumo, pero lo supera, proporcionando una visión integradora, que abarca desde los elementos de la vida corriente a la propia identidad. Asociada al desarrollo de un proyecto vital, la calidad de vida implica la capacidad para controlar las distintas facetas de la vida. Como contrapartida, supone la continua puesta en juego de los recursos disponibles, en una sucesión continua de tensiones y apuestas que el agente debe resolver para recuperar el sentido de sus relaciones con los entornos social y natural. Se señalan algunas paradojas que impregnan la calidad de vida de un fuerte contenido dialéctico y manifiestan la transformación de las relaciones entre el individuo y la sociedad.

Nutrients, Foods, and Colorectal Cancer Prevention

OpenAIRE

Song, Mingyang; Garrett, Wendy S.; Chan, Andrew T.

2015-01-01

Diet has an important role in the development of colorectal cancer. In the past few decades, findings from extensive epidemiologic and experimental investigation have linked consumption of several foods and nutrients to the risk of colorectal neoplasia. Calcium, fiber, milk, and whole grain have been associated with a lower risk of colorectal cancer, and red meat and processed meat with an increased risk. There is substantial evidence for the potential chemopreventive effects of vitamin D, fo...

Colorectal cancer complicating Crohn's disease.

Science.gov (United States)

Freeman, H J

2001-04-01

Some earlier studies have indicated that patients with inflammatory bowel disease, especially those with long-standing and extensive ulcerative colitis, have an increased risk of colorectal cancer. Moreover, others in tertiary care centres have suggested that patients with Crohn's disease also have a higher risk of colorectal cancer. Canadian data on colorectal cancer in Crohn's disease appear to be limited. For this investigation, a single clinician database of 877 patients with Crohn's disease was used. Altogether, there were six patients with colorectal cancer (ie, overall rate of 0.7%). All of these patients were men with an initial diagnosis of Crohn's disease established at a mean age of approximately 28 years, with either ileocolonic disease or colonic disease alone, but not with ileal disease alone. Although there was a predominance of women in the overall study population (ie, 56.1%), no women developed colorectal cancer. The clinical behaviour of Crohn's disease was classified as nonstricturing in all six patients with colorectal cancer, but in two patients, Crohn's disease was complicated by a perirectal abscess or a fistula. All cancers were located in the rectum and were diagnosed 30 years, 22 years, seven years, 18 years, 20 years and 40 years after Crohn's disease was initially diagnosed. In three patients, the cancer was detected in a residual rectal stump after a partial colon resection at least 10 years earlier. In five patients, localized extension of disease through the serosa, nodal or distant metastases (ie, liver, lung) was found at the time of cancer diagnosis; two patients have since died. The present study confirms that Crohn's disease involving the colon may be a possible risk factor for the development of colorectal cancer, at least in younger men, but, in this study, not in women. However, part of this increased risk in men may have been related to the presence of a rectal stump, rather than to Crohn's disease per se.

Colorectal Cancer Complicating Crohn's Disease

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Hugh J Freeman

2001-01-01

Full Text Available Some earlier studies have indicated that patients with inflammatory bowel disease, especially those with long-standing and extensive ulcerative colitis, have an increased risk of colorectal cancer. Moreover, others in tertiary care centres have suggested that patients with Crohn's disease also have a higher risk of colorectal cancer. Canadian data on colorectal cancer in Crohn's disease appear to be limited. For this investigation, a single clinician database of 877 patients with Crohn's disease was used. Altogether, there were six patients with colorectal cancer (ie, overall rate of 0.7%. All of these patients were men with an initial diagnosis of Crohn's disease established at a mean age of approximately 28 years, with either ileocolonic disease or colonic disease alone, but not with ileal disease alone. Although there was a predominance of women in the overall study population (ie, 56.1%, no women developed colorectal cancer. The clinical behaviour of Crohn's disease was classified as nonstricturing in all six patients with colorectal cancer, but in two patients, Crohn's disease was complicated by a perirectal abscess or a fistula. All cancers were located in the rectum and were diagnosed 30 years, 22 years, seven years, 18 years, 20 years and 40 years after Crohn's disease was initially diagnosed. In three patients, the cancer was detected in a residual rectal stump after a partial colon resection at least 10 years earlier. In five patients, localized extension of disease through the serosa, nodal or distant metastases (ie, liver, lung was found at the time of cancer diagnosis; two patients have since died. The present study confirms that Crohn's disease involving the colon may be a possible risk factor for the development of colorectal cancer, at least in younger men, but, in this study, not in women. However, part of this increased risk in men may have been related to the presence of a rectal stump, rather than to Crohn's disease per se.

Colorectal Cancer Screening: A Guide to the Guidelines

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Douglas K Rex

1999-01-01

Full Text Available The two most recent guidelines for colorectal cancer screening are those of the Agency for Healthcare Policy and Research, and the American Cancer Society. The guidelines are similar in many regards and reflect current literature, consensus opinion and compromise between members of multidisciplinary panels. The emphasis of both guidelines is to increase the options available for colorectal cancer screening. Increasing choice should expand the attractiveness of colorectal cancer screening to more patients and physicians, and the development of guidelines should help compel payers to provide reimbursement for colorectal cancer screening. These guidelines are summarized and evaluated as they pertain to colorectal cancer screening.

Sustentabilidade da dívida estadual brasileira: uma análise da relação dívida líquida e resultado primário

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Alessandro Aurélio Caldeira

2016-04-01

Full Text Available Resumo: A dívida pública é um importante elemento das finanças públicas e sua sustentabilidade é o indicativo da boa gestão da política fiscal de um governo. Este estudo tem o objetivo de verificar a sustentabilidade da dívida estadual, de forma agregada, a partir da análise de cointegração e da reação fiscal entre o resultado primário e a dívida líquida estadual, usando dados mensais de dezembro/2001 a maio/2014. Os resultados apontam a existência de cointegração entre as séries de resultado primário e de dívida líquida estadual e, além disso, revelam que os governos estaduais geraram superávits primários em face do crescimento da dívida. Assim, tem-se a indicação de que existiu sustentabilidade para a dívida dos estados no período estudado. Contudo, desafios recentes como o afrouxamento fiscal e a redução da atividade econômica colocam em dúvida a sustentabilidade futura.

Korean Guidelines for Colorectal Cancer Screening and Polyp Detection

International Nuclear Information System (INIS)

Lee, Bo In; Hong, Sung Pil; Kim, Seong Eun

2012-01-01

Colorectal cancer is currently the second most common cancer among Korean males and the fourth most common among females. Since the majority of colorectal cancer case present following the prolonged transformation of adenomas into carcinomas, early detection and removal of colorectal adenomas are vital methods in its prevention. Considering the increasing incidence of colorectal cancer and polyps in Korea, it is very important to establish national guidelines for colorectal cancer screening and polyp detection. The proposed guidelines have been developed by the Korean Multi-Society Task Force using evidence-based methods. Systematic reviews and meta-analyses have been used to form the statements contained in the guidelines. This paper discusses the epidemiology of colorectal cancers and adenomas in Korea as well as optimal methods for screening of colorectal cancer and detection of adenomas including fecal occult blood tests, radiologic tests, and endoscopic examinations.

Genetic Testing for Hereditary Colorectal Cancer

Science.gov (United States)

... before 50). Dave has Lynch syndrome and had colorectal cancer at 28. Amy found out she has Lynch syndrome when she was diagnosed with colorectal cancer days after turning 47. Why is it Important ...

¿Qué es la Calidad de Vida para los Estudiantes?

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Omar Felipe Dueñas García

2006-01-01

Full Text Available El termino calidad de vida es usualmente empleado de manera vaga y sin ninguna definición clara. En México la calidad de vida se a estudiado en pacientes enfermos, por eso nuestra inquietud de investigar sobre esta en estudiantes que no presentan ninguna enfermedad , limitación física, económica, social o mental Se encuestaron a 500 estudiantes universitarios de  la Universidad Autónoma de Puebla, Universidad de las Américas, Instituto Culinario de Puebla y U. De Guadalajara, a los cuales se les aplico uno de los diferentes 9 cuestionariosautoaplicables basados en estructura de escala global y a los parámetros clinimétricos de pregunta directa. El objetivo fue determinar lo que los estudiantes incluyen en calidad de vida  dependiendo en la calificación que otorguen a esta. Nos damos cuenta que para los estudiantes que considera que su calidad de vida muy agradable, se basan en que estén bien socioeconomicamente y estabilidad familiar; los que calificaron de totalmente agradable o agradable refieren tener todo sin especificar, buena los que ya mencionan aspectos negativos de su vida ,mientras para los que la calificaron como muy desagradable fue por falta de  éxito y superación personal, Sin mencionar el ambiente familiar, nadie califico su calidad de vida como totalmente desagradable. Para la mayoría de los profesionales  en la salud la calidad de vida se basa en el estado de salud del paciente (físico o mental sin tomar en cuenta aspectos tan importantes como son estabilidad familiar, económica, social y cultural En base a los resultados obtenidos se observo que para la mayoría de los estudiantes su calidad de vida no se basa en el estado de salud, sino en sus relaciones familiares, nivel socioeconómico y realización personal. Por lo que es necesario que en México se investigue mas sobre lo parámetros que se toman en cuanta para calificar la calidad de vida del paciente.

Qualidade de vida de graduandos de enfermagem Calidad de vida de estudiantes del grado de enfermería Quality of life of undergraduate nursing students

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Beatriz Marques de Oliveira

2011-02-01

Full Text Available O presente estudo objetivou descrever o perfil sociodemográfico dos estudantes de enfermagem e compreender o significado atribuído para sua atual qualidade de vida. Foram entrevistados 65 acadêmicos do 8º semestre do ano de 2007, por meio da aplicação de questionário autoreferido, com informações de dados sociodemográficos e questões abertas sobre qualidade de vida. A população de estudo foi predominantemente do sexo feminino, solteira, com idade entre 22 a 24 anos e com diferentes percepções sobre sua qualidade de vida, apreendidas por meio da vivência de fatores favoráveis e desfavoráveis no decorrer dos anos de aprendizado. O estudo destacou a percepção da qualidade de vida sob a ótica do estudante de enfermagemEl objetivo del presente estudio fue describir el perfil sociodemográfico de los estudiantes de enfermería y comprender sus percepciones sobre propia calidad de vida. Sesenta y cinco estudiantes del octavo semestre de 2007 fueran entrevistados por el uso del cuestionario, con informaciones sobre datos sociodemográficos y preguntas abiertas sobre calidad de vida. La populación era principalmente femenina, solas, con edad entre 22 y 24 años y con diversas opiniones sobre propia calidad de vida, prendida por la experiencia factores favorables e destructibles durante los años de la aprendizaje. El estudio destacó la percepción de la calidad de vida de los estudiantes de la enfermeríaThe present study aimed to describe socio-demographic profile of nursing students and to comprehend the meaning of quality of life under theirs perspective. Sixty-five students of eighth semester of 2007 were interviewed, by application of self reported questionnaire, with questions about socio demographic data and open question about quality of life. The population was mainly female, single, with age among 22 to 24 years old and with different perceptions about own quality of life, apprehended by experience of favorable and

Molecular Classification and Correlates in Colorectal Cancer

OpenAIRE

Ogino, Shuji; Goel, Ajay

2008-01-01

Molecular classification of colorectal cancer is evolving. As our understanding of colorectal carcinogenesis improves, we are incorporating new knowledge into the classification system. In particular, global genomic status [microsatellite instability (MSI) status and chromosomal instability (CIN) status] and epigenomic status [CpG island methylator phenotype (CIMP) status] play a significant role in determining clinical, pathological and biological characteristics of colorectal cancer. In thi...

Growth and progression of colorectal cancer

International Nuclear Information System (INIS)

Yamada, T.; Ushio, K.; Hirota, T.

1988-01-01

There is an increasing interest in the natural history of colorectal carcinoma, now that small polypoid lesions of the large intestine can be detected effectively by radiology and endoscopy. The problems of this histo- and morphogenesis of colorectal cancer have, however, remained unsettled because the observation of the sequential change of a lesion with time by follow-up radiology and/or endoscopy is impossible once its malignancy is proved. Clinically the retrospective review of radiographic findings in overlooked cases is the only means to evaluate the natural history of colorectal cancer. This paper attempts to estimate the growth rate of colorectal cancer, based on a retrospective review of radiographic findings of overlooked cases, and analyses of the radiographic features of small polypoid lesions which may develop into advanced cancers

PERCEPÇÕES DA QUALIDADE DE VIDA DE PESSOAS COM HIV/AIDS

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Betina Horner Schlindwein Meirelles

2010-01-01

Full Text Available Estudio que utiliza abordaje cualitativo, exploratorio-descriptivo con objetivo de identificar los elementos que influyen en la percepción de calidad de vida (CV de personas que viven con el VIH/SIDA. Para el estudio se realizaron entrevistas semiestructuradas con 14 personas. El análisis dio lugar a cuatro categorías, a saber: Calidad de vida: subjetiva y multidimensional; Vivir con VIH/SIDA y la calidad de vida; El cuidado para vivir con calidad y Los servicios de salud como potenciadores de la calidad de vida. Hay varios factores que influyen en la calidad de vida de esas personas, tales como: los factores físicos resultantes de la enfermedad, el cumplimiento del tratamiento y el uso de los antirretrovirales. En relación a los aspectos sociales, se identificó la presencia de la discriminación y los prejuicios. La aceptación del tratamiento con medicamentos antirretrovirales mejora significativamente la CV. La identificación de los factores que interfieren en la calidad de vida podrá contribuir para humanizar la atención a las personas que viven con VIH/SIDA, orientando el cuidado más allá de los aspectos clínicos, mediando para que esas personas puedan tener una vida con más calidad.

Qualidade de vida entre adolescentes: estudo seccional empregando o SF-12

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Marise Fagundes Silveira

2013-07-01

Full Text Available A adolescência é um período em que comportamentos potencialmente lesivos ao estado de saúde podem ser iniciados. A avaliação da qualidade de vida nesse contingente torna-se útil para a identificação de grupos em maior risco para comprometimento do bem estar geral. O presente estudo objetivou avaliar a qualidade de vida e fatores associados em uma amostra de 754 adolescentes, com faixa etária de 15 a 19 anos. Para a mensuração da qualidade de vida foi utilizada a versão na língua portuguesa do questionário 12-Item Short-Form Health Survey (SF 12. Os resultados apontaram níveis satisfatórios de qualidade de vida, sendo estes maiores com a prática frequente de atividade física e a ausência de condições como atividades trabalhistas e consumo de tabaco e bebida alcóolica. O sexo feminino foi correlacionado a menores escores em aspectos mentais da qualidade de vida.

Oestrogen receptor beta isoform expression in sporadic colorectal cancer, familial adenomatous polyposis and progressive stages of colorectal cancer

DEFF Research Database (Denmark)

Stevanato Filho, Paulo Roberto; Aguiar Júnior, Samuel; Begnami, Maria Dirlei

2017-01-01

BACKGROUND: Among the sex hormones, oestrogen may play a role in colorectal cancer, particularly in conjunction with oestrogen receptor-β (ERβ). The expression of ERβ isoform variants and their correlations with familial adenomatous polyposis (FAP) syndrome and sporadic colorectal carcinomas...... was identified in sporadic polyps and in sporadic colorectal cancer as well as in polyps from FAP syndrome patients compared with normal tissues (p expression in polyps (p ..., no differences were observed when sporadic colorectal carcinomas were compared to normal mucosa tissues. These findings suggest an association of the ERβ isoform variants in individuals affected by germline mutations of the APC gene. Progressively decreased expression of ERβ was found in polyps at early stages...

Radioimmunodetection of colorectal cancer

International Nuclear Information System (INIS)

Kim, E.E.; Deland, F.H.; Casper, S.; Corgan, R.L.; Primus, F.J.; Goldenberg, D.M.

1980-01-01

This study examines the accuracy of colorectal cancer radioimmunodetection. Twenty-seven patients with a history of histologically-confirmed colonic or rectal carcinoma received a high-titer, purified goat anti-CEA IgG labelled with 131 I at a total dose of at least 1.0 μCi. Various body views were scanned at 24 and 48 hours after administration of the radioantibody. Three additional cases were evaluated; one had a villous adenoma in the rectum and received the 131 I-labeled anti-CEA IgG, while two colonic carcinoma patients received normal goat IgG labelled with 131 I. All of the 7 cases with primary colorectal cancer showed true-positive tumor localization, while 20 of 25 sites of metastatic colorectal cancer detected by immune scintigraphy were corroborated by other detection measures. The sensitivity of the radioimmunodetection of colorectal cancers (primary and metastatic) was found to be 90% (true-positive rate), the putative specificity (true-negative rate) was 94%, and the apparent overall accuracy of the technique was 93%. Neither the case of a villous adenoma receiving the anti-CEA IgG nor the two cases of colonic cancer receiving normal goat IgG showed tumor radiolocalization. Very high circulating CEA titers did not appear to hinder successful tumor radiolocalization. These findings suggest that in colorectal cancers the method of CEA radioimmunodetection may be of value in preoperatively determining the location and extent of disease, in assessing possible recurrence or spread postoperatively, and in localizing the source of CEA production in patients with rising or elevated CEA titers. An ancilliary benefit could be a more tumor-specific detection test for confirming the findings of other, more conventional diagnostic measures

Mitotic and apoptotic activity in colorectal neoplasia.

Science.gov (United States)

Kohoutova, Darina; Pejchal, Jaroslav; Bures, Jan

2018-05-18

Colorectal cancer (CRC) is third most commonly diagnosed cancer worldwide. The aim of the prospective study was to evaluate mitosis and apoptosis of epithelial cells at each stage of colorectal neoplasia. A total of 61 persons were enrolled into the study: 18 patients with non-advanced colorectal adenoma (non-a-A), 13 patients with advanced colorectal adenoma (a-A), 13 patients with CRC and 17 controls: individuals with normal findings on colonoscopy. Biopsy samples were taken from pathology (patients) and healthy mucosa (patients and healthy controls). Samples were formalin-fixed paraffin-embedded and stained with haematoxylin-eosin. Mitotic and apoptotic activity were evaluated in lower and upper part of the crypts and in the superficial compartment. Apoptotic activity was also assessed using detection of activated caspase-3. In controls, mitotic activity was present in lower part of crypts, accompanied with low apoptotic activity. Mitotic and apoptotic activity decreased (to almost zero) in upper part of crypts. In superficial compartment, increase in apoptotic activity was observed. Transformation of healthy mucosa into non-a-A was associated with significant increase of mitotic activity in lower and upper part of the crypts and with significant increase of apoptotic activity in all three compartments; p colorectal neoplasia were observed. Detection of activated caspase-3 confirmed the above findings in apoptotic activity. Significant dysregulation of mitosis and apoptosis during the progression of colorectal neoplasia, corresponding with histology, was confirmed. In patients with sporadic colorectal neoplasia, healthy mucosa does not display different mitotic and apoptotic activity compared to mucosa in healthy controls and therefore adequate endoscopic/surgical removal of colorectal neoplasia is sufficient.

Profile of colorectal cancer in Eastern India.

Science.gov (United States)

Sarkar, Snigdha; Mukherjee, Ramanuj; Paira, Susil Kumar; Roy, Bipradas; Banerjee, Shubhabrata; Mukherjee, Saibal Kumar

2012-12-01

Although colorectal cancer is a major cause of concern in the western population, recent studies are showing the incidence and mortality of colorectal cancer to be rapidly rising in Asia. The present study is an insight into the epidemiological profile of colorectal cancer of a representative Eastern Indian population. Over a period of three years, all histologically proved patients with colorectal cancer were assessed for age, sex, body mass index, dietary habits, socioeconomic status and stage of disease. Of a total of 168 patients male to female ratio was 1.7:1.The mean age of presentation was 47.01 years. Although colorectal cancer has been known as a disease of sedentary obese men, 41.66% of the patients were from a low socioeconomic rural set-up and 40.47% were involved in heavy physical labour with only 15% of being obese; 62% patients were harbouring a locally advanced disease at the time of presentation. The epidemiological pattern of colorectal cancer in India is different from that of the west as regards to earlier age of presentation, prevalence in low socio economic class with low fat diet and scanty meat intake.

Colorectal Cancer: What You Should Know

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... Products For Consumers Home For Consumers Consumer Updates Colorectal Cancer: What You Should Know Share Tweet Linkedin Pin ... with—and more than 50,000 died from—colorectal cancer, according to the National Cancer Institute. It is ...

Colorectal Cancer

Science.gov (United States)

... possible. Research will help us better understand whether chemotherapy can benefit elderly colorectal cancer patients. Such patients often do not receive chemotherapy due to concerns about side effects. We will ...

Comparison of VIDAS and Radioimmunoassay Methods for Measurement of Cortisol Concentration in Bovine Serum

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Daniela Proverbio

2013-01-01

Full Text Available Radioimmunoassay (RIA is the “gold standard” method for evaluation of serum cortisol concentration. The VIDAS cortisol test is an enzyme-linked fluorescent assay designed for the MiniVidas system. The aim of this study was to compare the VIDAS method with RIA for measurement of bovine serum cortisol concentration. Cortisol concentrations were evaluated in 40 cows using both VIDAS and RIA methods, the latter as the reference method. A paired Student’s -test, Pearson’s correlation analysis, Bland-Altman plot, and Deming regression analysis were used to compare the two methods. There was no statistically significant difference between mean serum cortisol concentrations measured by VIDAS or RIA methods (. Both methods were able to detect significant differences in mean low and high cortisol concentrations ( RIA and VIDAS. The correlation coefficient was low, but a Bland-Altman plot and Deming regression analysis show neither constant nor proportional error. The VIDAS method produced slightly higher values than RIA, but the difference was small and in no case did the mean value move the normal range. Results suggest that VIDAS method is suitable for the determination of bovine serum cortisol concentration in studies of large numbers of animals.

Colorectal liver metastases: factors affecting outcome after surgery

NARCIS (Netherlands)

Snoeren, N.

2013-01-01

Colorectal cancer is the second leading cause of cancer related death in Europe. The overall survival rate of patients with colorectal cancer is greatly affected by the presence of liver metastases, which occurs in about 50% of patients. Radical resection of colorectal liver metastases means a

Definition of colorectal anastomotic leakage: A consensus survey among Dutch and Chinese colorectal surgeons.

Science.gov (United States)

van Rooijen, Stefanus J; Jongen, Audrey Chm; Wu, Zhou-Qiao; Ji, Jia-Fu; Slooter, Gerrit D; Roumen, Rudi Mh; Bouvy, Nicole D

2017-09-07

To determine the level of consensus on the definition of colorectal anastomotic leakage (CAL) among Dutch and Chinese colorectal surgeons. Dutch and Chinese colorectal surgeons were asked to partake in an online questionnaire. Consensus in the online questionnaire was defined as > 80% agreement between respondents on various statements regarding a general definition of CAL, and regarding clinical and radiological diagnosis of the complication. Fifty-nine Dutch and 202 Chinese dedicated colorectal surgeons participated in the online survey. Consensus was found on only one of the proposed elements of a general definition of CAL in both countries: 'extravasation of contrast medium after rectal enema on a CT scan'. Another two were found relevant according to Dutch surgeons: 'necrosis of the anastomosis found during reoperation', and 'a radiological collection treated with percutaneous drainage'. No consensus was found for all other proposed elements that may be included in a general definition. There is no universally accepted definition of CAL in the Netherlands and China. Diagnosis of CAL based on clinical manifestations remains a point of discussion in both countries. Dutch surgeons are more likely to report 'subclinical' leaks as CAL, which partly explains the higher reported Dutch CAL rates.

Atitude religiosa e sentido da vida: um estudo correlacional

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Thiago Antônio Avellar de Aquino

Full Text Available A presente pesquisa abordou o sentido da vida (Viktor Frankl e a atitude religiosa. Para a logoterapia, a religiosidade não significa necessariamente a opção por uma crença religiosa, mas pode ser uma das possíveis maneiras de o homem encontrar sentido para a vida. O objetivo deste estudo foi investigar a relação entre o sentido de vida e a atitude religiosa de forma transversal e correlacional. A amostra foi composta por 300 sujeitos de ambos os sexos, 37% homens e 63% mulheres, com idade média de 42 anos. Os instrumentos utilizados foram o Teste Propósito de Vida (PIL-Test, de James C. Crumbauch e Leonard T. Maholick, e a Escala de Atitude Religiosa/Espiritualidade, de Aquino. Os resultados apontam correlações positivas entre a atitude religiosa e a realização existencial, a atitude religiosa e a idade, o desespero existencial e o vazio existencial e a realização existencial e a idade, havendo também correlações negativas entre a atitude religiosa e o desespero existencial, a atitude religiosa e o vazio existencial, o desespero existencial e a realização existencial e o vazio existencial e a realização existencial. Concluiu-se que a atitude religiosa é uma forma de encontro de sentido de vida bem como um elemento de prevenção do vazio existencial e do desespero existencial.

Exercise and Low-Dose Ibuprofen for Cognitive Impairment in Colorectal Cancer Patients Receiving Chemotherapy

Science.gov (United States)

2018-03-13

Cognitive Impairment; Stage 0 Colorectal Cancer; Stage I Colorectal Cancer; Stage II Colorectal Cancer; Stage IIA Colorectal Cancer; Stage IIB Colorectal Cancer; Stage IIC Colorectal Cancer; Stage III Colorectal Cancer; Stage IIIA Colorectal Cancer; Stage IIIB Colorectal Cancer; Stage IIIC Colorectal Cancer

HISTOMORPHOLOGICAL STUDY OF COLORECTAL MALIGNANCIES

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Sarvesh

2015-07-01

Full Text Available BACKGROUND: Colorectal cancer is the most common cancer in men and in women worldwide. Incidence rates of colorectal cancer vary 10 - fold in both sexes worldwide, Within Asia, the incidence rates vary widely and are uniformly low in all south Asian countries and high i n all developed Asian countries. Fortunately, the age adjusted incidence rates of colorectal cancer in all the Indian cancer registries are very close to the lowest rates in the world. The present study is under taken to study the prevalence and types of c olorectal cancer among the patients in the rural population in and around Chidambaram. OBJECTIVES: To study the prevalence of malignant colorectal neoplasms among the speci mens received in the Department of Pathology and the gross and histomorphological pa ttern of the lesions and finally to correlate the findings with clinical data. METHOD: The materials consisted of 68 specimens who were submitted to the Department of Pathology, during the period of Jan 2008 - Dec 2012. Data collected and entered in MS - Excel and were analyzed using SPSS - 16. RESULTS : Out of 8454 colonoscopic specimens, 68(0.8% showed colorectal malignancy. A higher frequency of colorectal was seen in 6 th decade. Out of 68 specimens of malignant neoplasms majority were Carcinoma of the Rectum (79.41% followed in decreasing order of frequency by malignant lesions of descending colon(8.82%, ascending and Sigmoid colon (4.41% each, recto - sigmoid (2.94% and cecum (2.63%, and transverse colon (2.63%. Youngest patient was 19 years old and the o ldest patient was 80 years old with a mean age of 49.5 years and median age of 50 years. CONCLUSION: Colorectal cancer is a common and lethal disease. The adenoma carcinoma. S equence offers a window of opportunity in which the precursor lesion or early car cinoma can be removed endoscopically to prevent systematic disease. The result of a careful and systematic examination of surgical specimens from patients with

Avaliação da Qualidade de Vida Infantil: O Inventário Sistémico de Qualidade de Vida para Crianças

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Marta Fonseca

2014-01-01

Full Text Available A avaliação da qualidade de vida infantil apresenta especificidades metodológicas. O objetivo do presente estudo é analisar as características psicométricas da versão portuguesa do Inventaire Systémique de Qualité de Vie pour Enfants (ISQV-C, que assenta numa abordagem conceptual e metodológica inovadora para a autoavaliação da qualidade de vida, por ser interativo e lúdico, possuir uma psicometria que explora diversas pontuações e permitir uma análise de cada domínio de vida. Participaram do estudo 120 crianças portuguesas, dos 8 aos 12 anos de idade. Os resultados apontam para uma consistência interna satisfatória das quatro pontuações do ISQV-C (Estado, Objetivo, Importância e Qualidade de Vida, atestam validade convergente ao instrumento, não sendo favoráveis à existência de uma estrutura fatorial. Demonstra-se a adequação psicométrica e o interesse da versão portuguesa do ISQV-C.

Colorectal cancer screening awareness among physicians in Greece

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Chatzimichalis Georgios

2006-06-01

Full Text Available Abstract Background Data comparison between SEER and EUROCARE database provided evidence that colorectal cancer survival in USA is higher than in European countries. Since adjustment for stage at diagnosis markedly reduces the survival differences, a screening bias was hypothesized. Considering the important role of primary care in screening activities, the purpose of the study was to investigate the colorectal cancer screening awareness among Hellenic physicians. Methods 211 primary care physicians were surveyed by mean of a self-reported prescription-habits questionnaire. Both physicians' colorectal cancer screening behaviors and colorectal cancer screening recommendations during usual check-up visits were analyzed. Results Only 50% of physicians were found to recommend screening for colorectal cancer during usual check-up visits, and only 25% prescribed cost-effective procedures. The percentage of physicians recommending stool occult blood test and sigmoidoscopy was 24% and 4% respectively. Only 48% and 23% of physicians recognized a cancer screening value for stool occult blood test and sigmoidoscopy. Colorectal screening recommendations were statistically lower among physicians aged 30 or less (p = 0.012. No differences were found when gender, level and type of specialization were analyzed, even though specialists in general practice showed a trend for better prescription (p = 0.054. Conclusion Contemporary recommendations for colorectal cancer screening are not followed by implementation in primary care setting. Education on presymptomatic control and screening practice monitoring are required if primary care is to make a major impact on colorectal cancer mortality.

Coffee Consumption and the Risk of Colorectal Cancer.

Science.gov (United States)

Schmit, Stephanie L; Rennert, Hedy S; Rennert, Gad; Gruber, Stephen B

2016-04-01

Coffee contains several bioactive compounds relevant to colon physiology. Although coffee intake is a proposed protective factor for colorectal cancer, current evidence remains inconclusive. We investigated the association between coffee consumption and risk of colorectal cancer in 5,145 cases and 4,097 controls from the Molecular Epidemiology of Colorectal Cancer (MECC) study, a population-based case-control study in northern Israel. We also examined this association by type of coffee, by cancer site (colon and rectum), and by ethnic subgroup (Ashkenazi Jews, Sephardi Jews, and Arabs). Coffee data were collected by interview using a validated, semi-quantitative food frequency questionnaire. Coffee consumption was associated with 26% lower odds of developing colorectal cancer [OR (drinkers vs. non-drinkers), 0.74; 95% confidence interval (CI), 0.64-0.86; P consumption alone (OR, 0.82; 95% CI, 0.68-0.99; P = 0.04) and for boiled coffee (OR, 0.82; 95% CI, 0.71-0.94; P = 0.004). Increasing consumption of coffee was associated with lower odds of developing colorectal cancer. Compared with 2.5 servings/day (OR, 0.46; 95% CI, 0.39-0.54; P colorectal cancer (Ptrend cancers. Coffee consumption may be inversely associated with risk of colorectal cancer in a dose-response manner. Global coffee consumption patterns suggest potential health benefits of the beverage for reducing the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev; 25(4); 634-9. ©2016 AACR. ©2016 American Association for Cancer Research.

Differential expression of proteomics models of colorectal cancer, colorectal benign disease and healthy controls

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Zhang Shu-Jun

2010-03-01

Full Text Available Abstract Background Colorectal cancer (CRC is often diagnosed at a late stage with concomitant poor prognosis. The hypersensitive analytical technique of proteomics can detect molecular changes before the tumor is palpable. The surface-enhanced laser desorption/ionization-time of flight-mass spectra (SELDI-TOF-MS is a newly-developed technique of evaluating protein separation in recent years. The protein chips have established the expression of tumor protein in the serum specimens and become the newly discovered markers for tumor diagnosis. The objective of this study was to find new markers of the diagnosis among groups of CRC, colorectal benign diseases (CBD and healthy controls. The assay of SELDI-TOF-MS with analytical technique of protein-chip bioinformatics was used to detect the expression of protein mass peaks in the sera of patients or controls. One hundred serum samples, including 52 cases of colorectal cancer, 27 cases of colorectal benign disease, and 21 cases of healthy controls, were examined by SELDI-TOF-MS with WCX2 protein-chips. Results The diagnostic models (I, II and III were setup by analyzed the data and sieved markers using Ciphergen - Protein-Chip-Software 5.1. These models were combined with 3 protein mass peaks to discriminate CRC, CBD, and healthy controls. The accuracy, the sensitivity and the particularity of cross verification of these models are all highly over 80%. Conclusions The SELDI-TOF-MS is a useful tool to help diagnose colorectal cancer, especially during the early stage. However, identification of the significantly differentiated proteins needs further study.

Calidad de vida de los cuidadores familiares

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Clara Inés Giraldo Molina

2006-01-01

Full Text Available El objetivo de esta investigación es describir, desde la perspectiva etnográfica, cómo podría estar afectada la calidad de vida de los cuidadores familiares de adultos mayores con dependencia funcional, como consecuencia del desempeño del rol de cuidador, y según su percepción. Se trata de un estudio cualitativo etnográfico, con apoyo en la etnografía enfocada, en 14 cuidadoras familiares de adultos mayores de 65 años, con más de seis meses a su cuidado, en el municipio de Envigado, Colombia, en 2002, y una muestra de quince entrevistas en profundidad. El análisis de las entrevistas identificó siete grandes temas o categorías con las percepciones de las cuidadoras sobre su rol y los efectos de éste en su calidad de vida: significado de calidad de vida, percepción de la cuidadora sobre el rol de cuidadora, consecuencias del rol sobre su salud física y mental, relaciones cuidadora y persona cuidada, conocimientos y aprendizajes sobre el cuidado de las personas, apoyos que recibe la cuidadora para el cuidado, y la invisibilidad del trabajo de las cuidadoras. Las categorías que emergieron coinciden con las de otros estudios; se hace énfasis en la categoría "la invisibilidad del trabajo de la cuidadora familiar", en tanto es la menos documentada en la literatura, y en la importancia del acercamiento a los valores y las tradiciones de grupos para la interpretación de las respuestas de su vida social.

Metallic stent placement for the management of acute colorectal obstruction caused by colorectal carcinomas: its effect on scheduled surgery

International Nuclear Information System (INIS)

Cao Yan; Liu Bingyan; Mao Aiwu; Yin Xiang; Gao Zhongdu

2011-01-01

Objective: To prospectively evaluate the safety and clinical efficacy of a newly designed self-expandable metallic stent (SEMS) placement in the treatment of patients with acute malignant colorectal obstruction due to colorectal carcinomas. Methods: During the period from April 2001 to October 2007, a total of 52 patients with acute malignant colorectal obstruction were treated with stent placement by using a new designed SEMS, which was employed as a preoperative transit means. All the patients were followed up and the relevant data, including technical success rate, clinical efficacy, complications and overall survival rate, were documented. The results were analyzed. Results: Stent placement was successfully carried out in all patients except for two patients who showed complete colorectal obstruction. No procedure-related complications occurred. Technical success rate was 96% (50/52). Two days after the treatment, the relief rate of colorectal obstruction was 98% (49/50). Postoperative complications included stent migration (n=4), anal pain (n=2) and stool impaction (n=1). The stool impaction seen in one patient was successfully removed away with endoscopic manipulation two days after stent placement. An elective one-stage surgical procedure was performed in all 50 patients who successfully received a SEMS placement within a mean interval of (8±2) days (ranged 4-11 days) after stent placement. Mean follow-up time was (36±12) months with a range of (3-70) months. All patients remained alive at the time of this report. Conclusion: The newly designed SEMS placement used as a preoperative transit means is a safe and effective intervention for colonic decompression in patients with acute malignant colorectal obstruction due to colorectal carcinomas. It can reliably ensure most of patients with colorectal carcinomas to successfully accomplish an elective surgery. (authors)

ACR Appropriateness Criteria® Colorectal Cancer Screening.

Science.gov (United States)

Moreno, Courtney; Kim, David H; Bartel, Twyla B; Cash, Brooks D; Chang, Kevin J; Feig, Barry W; Fowler, Kathryn J; Garcia, Evelyn M; Kambadakone, Avinash R; Lambert, Drew L; Levy, Angela D; Marin, Daniele; Peterson, Christine M; Scheirey, Christopher D; Smith, Martin P; Weinstein, Stefanie; Carucci, Laura R

2018-05-01

This review summarizes the relevant literature regarding colorectal screening with imaging. For individuals at average or moderate risk for colorectal cancer, CT colonography is usually appropriate for colorectal cancer screening. After positive results on a fecal occult blood test or immunohistochemical test, CT colonography is usually appropriate for colorectal cancer detection. For individuals at high risk for colorectal cancer (eg, hereditary nonpolyposis colorectal cancer, ulcerative colitis, or Crohn colitis), optical colonoscopy is preferred because of its ability to obtain biopsies to detect dysplasia. After incomplete colonoscopy, CT colonography is usually appropriate for colorectal cancer screening for individuals at average, moderate, or high risk. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment. Copyright © 2018 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Herbert Marcuse: la vida y la muerte

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Miguel Ángel Hernández

1979-01-01

Full Text Available Una clave inicial con la que se puede recorrer a vuelo de pájaro -corno lo exige la limitación de una reseña-la obra de Herbert Marcuse es una valoración, instalada en el fundamento de su reflexión, según la cual la finalidad es la vida del hombre" ... es decir, la felicidad". Su teoría crítica eleva al nivel universalizante el objetivo que los individuos buscan en la vida corriente y han buscado siempre: la felicidad. En ese nivel ha de responderse por la riqueza del género, por el bien de la especie.

Sueño y calidad de vida

OpenAIRE

Miró, Elena; Cano-Lozano, Carmen; Buela-Casal, Gualberto

2008-01-01

Existe una estrecha interrelación entre los procesos de sueño y el estado general de salud física y psicológica de una persona. En el presente artículo se revisan algunas de las principales líneas de investigación que abordan las relaciones entre el sueño y la calidad de vida. Se analiza la influencia de los diferentes patrones de sueño (patrón de sueño corto, intermedio y largo) y de la calidad del sueño (sueño eficiente/no eficiente) en la salud y la calidad de vida. Se examinan las consecu...

Nutritional status assessment in colorectal cancer patients

OpenAIRE

Joana Pedro Lopes; Paula Manuela de Castro Cardoso Pereira; Ana Filipa dos Reis Baltazar Vicente; Alexandra Bernardo; María Fernanda de Mesquita

2013-01-01

The present study intended to evaluate the nutritional status of Portuguese colorectal patients and associated it with surgery type as well as quality of life outcomes. Malnutrition can affect up to 85% of cancer patients and specifically 30-60% in colorectal cancer and can significantly influence health outcomes. A sample of 50 colorectal cancer patients was evaluated in what refers to several anthropometric measures, food intake, clinical history, complications rate before and after surgery...

Self-renewal molecular mechanisms of colorectal cancer stem cells

OpenAIRE

Pan, Tianhui; Xu, Jinghong; Zhu, Yongliang

2016-01-01

Colorectal cancer stem cells (CCSCs) represent a small fraction of the colorectal cancer cell population that possess self-renewal and multi-lineage differentiation potential and drive tumorigenicity. Self-renewal is essential for the malignant biological behaviors of colorectal cancer stem cells. While the self-renewal molecular mechanisms of colorectal cancer stem cells are not yet fully understood, the aberrant activation of signaling pathways, such as Wnt, Notch, transforming growth facto...

Screening for colorectal cancer in defunctioned colons.

Science.gov (United States)

Akbar, Fayyaz; Quyn, Aaron; Steele, Robert

2018-01-01

Objectives Population-based colorectal (bowel) cancer screening using faecal occult blood tests leads to a reduction in cause-specific mortality. However, in people where the colon is defunctioned, the use of standard faecal occult blood test is not appropriate. The aim of this study was to examine the current trends of clinical practice for colorectal cancer screening in people with defunctioned colons. Methods An online survey was performed using SurveyMonkey. All members of the Association of Coloproctology of Great Britain and Ireland were invited by email to participate. Reminders were sent to non-responders and partial responders till six weeks. All responses were included in our analysis. Results Of the 206 (34.59%) questionnaires completed, all questions were answered in 110 (55.8%). Among responders, 94 (85.4%) were colorectal consultant surgeons, 72% had worked in their current capacity for more than five years, and 105 (50.9%) had encountered colorectal cancer in defunctioned colons during their career. Some 72.2% of responders stated that a screening test for colorectal cancer in patients with defunctioned colons was currently not offered, or that they did not know whether or not it was offered in their area. Conclusions Bowel screening in the United Kingdom is currently not offered to 72.2% of the age appropriate population with defunctioned colons. Among responding colorectal surgeons, 50% had encountered colorectal cancer in such patients. There is considerable variability in clinical practice regarding the optimal age for onset of screening, time interval, and the optimal modality to offer for screening in such cases.

Predictors of advanced colorectal neoplasia for colorectal cancer screening.

Science.gov (United States)

Wong, Martin C S; Lam, Thomas Y T; Tsoi, Kelvin K F; Chan, Victor C W; Hirai, Hoyee W; Ching, Jessica Y L; Sung, Joseph J Y

2014-05-01

The Asia-Pacific Colorectal Screening (APCS) score based on age, gender, family history, and smoking is useful to predict advanced colorectal neoplasia (ACN) in asymptomatic Asian subjects. To evaluate the factors in addition to those of APCS associated with ACN colonoscopic findings. Data from 5,220 asymptomatic subjects aged between 50 and 70 years who underwent screening colonoscopy in a community center between 2008 and 2012 were analyzed. One binary logistic regression analysis was conducted in 2013 with the presence of ACN or cancer as the outcome, controlling for APCS score, alcohol consumption, BMI, hypertension, and other chronic diseases as independent variables. The average participant age was 57.7 years (SD=4.9) and 47.5% were men. Advanced neoplasms or cancers were identified at colonoscopy in 5.6% of all screening participants. From multivariate regression analysis, APCS score≥4 (adjusted OR [AOR]=1.74, 95% CI=1.34, 2.25, pstatistic of APCS score alone was 0.560 (95% CI=0.524, 0.595, p=0.001) and that of APCS score plus BMI, hypertension, and alcohol consumption was 0.613 (95% CI=0.578, 0.648, p<0.001). Alcohol consumption, hypertension, and BMI are independent predictors of ACN, which could be incorporated into the APCS for prioritizing Asian asymptomatic subjects for colorectal cancer screening. Copyright © 2014. Published by Elsevier Inc.

Development of Colorectal-Targeted Dietary Supplement Tablets Containing Natural Purple Rice Bran Oil as a Colorectal Chemopreventive

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Busaban Sirithunyalug

2018-04-01

Full Text Available Colorectal cancer occurs due to various factors. The important risks are dietary lifestyle and inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. It has been found that the inhibitory enzyme cyclooxygenase-2 (COX-2 in the colorectal region can potentially reduce the risk of colorectal cancer. The present study investigated rice bran oil from natural purple rice bran, which exhibits antioxidant and anti-inflammatory activity. This study aimed to evaluate the bioactive compound content of natural purple rice bran oil (NPRBO derived from native Thai purple rice and the anti-inflammatory activity of NPRBO in colorectal cancer cells, and to develop a colorectal delivery platform in the form of film-coated tablets. NPRBO from the rice bran of five different Thai purple rice cultivars, namely Khao’ Gam Leum-Phua (KGLP, Khao’ Gam Boung (KGB, Khao’ Gam Thor (KGT, Khao’ Gam Pah E-Kaw (KGPEK, and Khao’ Niaw Dam (KND, were extracted using the supercritical carbon dioxide extraction technique. The amount of γ-oryzanol (ORY, tocotrienols, and tocopherols present in NPRBOs and the in vitro anti-inflammatory activity of NPRBO were investigated. The highest anti-inflammatory NPRBO was transformed into a dry and free-flowing powder by liquisolid techniques. Then, it was compressed into core tablets and coated with Eudragit®L100 and Eudragit® NE30D. The in vitro release study of the film-coated NPRBO tablets was performed in three-phase simulated gastrointestinal media. The cultivar KGLP was superior to the other samples in terms of the ORY, tocotrienol and tocopherol contents and anti-inflammatory activity. Aerosil® was the most suitable absorbent for transforming NPRBO into a free-flowing powder and was used to prepare the NPRBO core tablets. The in vitro KGLP-NPRBO film-coated tablet release profile showed that no ORY was released at gastric pH while 85% of ORY was released at pH 7.4 after 6 h; this would be expected to

Development of Colorectal-Targeted Dietary Supplement Tablets Containing Natural Purple Rice Bran Oil as a Colorectal Chemopreventive

Science.gov (United States)

Sirithunyalug, Busaban; Saenjum, Chalermpong; Charumanee, Suporn; Chaiyasut, Chaiyavat; Sirithunyalug, Jakkapan; Tipduangta, Pratchaya

2018-01-01

Colorectal cancer occurs due to various factors. The important risks are dietary lifestyle and inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. It has been found that the inhibitory enzyme cyclooxygenase-2 (COX-2) in the colorectal region can potentially reduce the risk of colorectal cancer. The present study investigated rice bran oil from natural purple rice bran, which exhibits antioxidant and anti-inflammatory activity. This study aimed to evaluate the bioactive compound content of natural purple rice bran oil (NPRBO) derived from native Thai purple rice and the anti-inflammatory activity of NPRBO in colorectal cancer cells, and to develop a colorectal delivery platform in the form of film-coated tablets. NPRBO from the rice bran of five different Thai purple rice cultivars, namely Khao’ Gam Leum-Phua (KGLP), Khao’ Gam Boung (KGB), Khao’ Gam Thor (KGT), Khao’ Gam Pah E-Kaw (KGPEK), and Khao’ Niaw Dam (KND), were extracted using the supercritical carbon dioxide extraction technique. The amount of γ-oryzanol (ORY), tocotrienols, and tocopherols present in NPRBOs and the in vitro anti-inflammatory activity of NPRBO were investigated. The highest anti-inflammatory NPRBO was transformed into a dry and free-flowing powder by liquisolid techniques. Then, it was compressed into core tablets and coated with Eudragit®L100 and Eudragit® NE30D. The in vitro release study of the film-coated NPRBO tablets was performed in three-phase simulated gastrointestinal media. The cultivar KGLP was superior to the other samples in terms of the ORY, tocotrienol and tocopherol contents and anti-inflammatory activity. Aerosil® was the most suitable absorbent for transforming NPRBO into a free-flowing powder and was used to prepare the NPRBO core tablets. The in vitro KGLP-NPRBO film-coated tablet release profile showed that no ORY was released at gastric pH while 85% of ORY was released at pH 7.4 after 6 h; this would be expected to occur in

[Chinese Protocol of Diagnosis and Treatment of Colorectal Cancer].

Science.gov (United States)

2018-04-01

Colorectal cancer is one of the most common malignant tumors in China. In 2012 one million thirty six thousand cases of colorectal cancer were diagnosed all over the world, two hundred fifty three thousand cases were diagnosed in China (accounted for 18.6%). China has the largest number of new cases of colorectal cancer in the world. Colorectal cancer has becoming a serious threat of Chinese residents' health. In 2010, the National Ministry of Health organized colorectal cancer expertise of the Chinese Medical Association to write the "Chinese Protocol of Diagnosis and Treatment of Colorectal Cancer" (2010edition), and publish it publicly. In recent years, the National Health and Family Planning Commission has organized experts to revised the protocol 2 times: the first time in 2015, the second time in 2017. The revised part of "Chinese Protocol of Diagnosis and Treatment of Colorectal Cancer" (2017 edition) involves new progress in the field of imaging examination, pathological evaluation, surgery, chemotherpy and radiotherapy. The 2017 edition of the protocol not only referred to the contents of the international guidelines, but also combined with the specific national conditions and clinical practice in China, and also included many evidence-based clinical data in China recently. The 2017 edition of the protocol would further promote the standardization of diagnosis and treatment of colorectal cancer in China, improve the survival and prognosis of patients, and benefit millions of patients with colorectal cancer and their families.

Optimizing Outcomes of Colorectal Cancer Screening

NARCIS (Netherlands)

R.G.S. Meester (Reinier)

2017-01-01

markdownabstractColorectal cancer is a leading cause of cancer deaths. Screening for colorectal cancer is implemented in an increasing number of settings, but performance of programs is often suboptimal. In this thesis, advanced modeling, informed by empirical data, was used to identify areas for

Colorectal Cancer Prevention (PDQ®)—Patient Version

Science.gov (United States)

Colorectal cancer prevention strategies can include avoiding known risk factors, having a healthy lifestyle, taking aspirin, and removing polyps. Learn more about preventing colorectal cancer in this expert-reviewed summary.

DERECHO A LA VIDA DIGNA EL CONCEPTO JURÍDICO DEL DOLOR DESDE EL DERECHO CONSTITUCIONAL

OpenAIRE

Gustavo Adolfo García Arango

2007-01-01

El concepto jurídico del dolor desde el derecho constitucional ha sido abarcado en una sola perspectiva: el reconocimiento del derecho fundamental a la vida, en condiciones dignas. El derecho a la vida se ve afectado por conexidad:cuando el dolor no permite lleva una vida equilibrada en todos sus aspectos, permite la protección constitucional a la vida. Se entiende que el cuerpo es el elemento central en una teoría sobre la vida digna; un cuerpo sufriente, enfermo es un cuerpo limitado y cond...

Diet, lifestyle, and molecular alterations that drive colorectal carcinogenesis

NARCIS (Netherlands)

Diergaarde, B.

2004-01-01

Environmental factors have been repeatedly implicated in the etiology of colorectal cancer, and much is known about the molecular events involved in colorectal carcinogenesis. The relationships between environmental risk factors and the molecular alterations that drive colorectal carcinogenesis are

Genetic Mechanisms of Immune Evasion in Colorectal Cancer.

Science.gov (United States)

Grasso, Catherine S; Giannakis, Marios; Wells, Daniel K; Hamada, Tsuyoshi; Mu, Xinmeng Jasmine; Quist, Michael; Nowak, Jonathan A; Nishihara, Reiko; Qian, Zhi Rong; Inamura, Kentaro; Morikawa, Teppei; Nosho, Katsuhiko; Abril-Rodriguez, Gabriel; Connolly, Charles; Escuin-Ordinas, Helena; Geybels, Milan S; Grady, William M; Hsu, Li; Hu-Lieskovan, Siwen; Huyghe, Jeroen R; Kim, Yeon Joo; Krystofinski, Paige; Leiserson, Mark D M; Montoya, Dennis J; Nadel, Brian B; Pellegrini, Matteo; Pritchard, Colin C; Puig-Saus, Cristina; Quist, Elleanor H; Raphael, Ben J; Salipante, Stephen J; Shin, Daniel Sanghoon; Shinbrot, Eve; Shirts, Brian; Shukla, Sachet; Stanford, Janet L; Sun, Wei; Tsoi, Jennifer; Upfill-Brown, Alexander; Wheeler, David A; Wu, Catherine J; Yu, Ming; Zaidi, Syed H; Zaretsky, Jesse M; Gabriel, Stacey B; Lander, Eric S; Garraway, Levi A; Hudson, Thomas J; Fuchs, Charles S; Ribas, Antoni; Ogino, Shuji; Peters, Ulrike

2018-06-01

To understand the genetic drivers of immune recognition and evasion in colorectal cancer, we analyzed 1,211 colorectal cancer primary tumor samples, including 179 classified as microsatellite instability-high (MSI-high). This set includes The Cancer Genome Atlas colorectal cancer cohort of 592 samples, completed and analyzed here. MSI-high, a hypermutated, immunogenic subtype of colorectal cancer, had a high rate of significantly mutated genes in important immune-modulating pathways and in the antigen presentation machinery, including biallelic losses of B2M and HLA genes due to copy-number alterations and copy-neutral loss of heterozygosity. WNT/β-catenin signaling genes were significantly mutated in all colorectal cancer subtypes, and activated WNT/β-catenin signaling was correlated with the absence of T-cell infiltration. This large-scale genomic analysis of colorectal cancer demonstrates that MSI-high cases frequently undergo an immunoediting process that provides them with genetic events allowing immune escape despite high mutational load and frequent lymphocytic infiltration and, furthermore, that colorectal cancer tumors have genetic and methylation events associated with activated WNT signaling and T-cell exclusion. Significance: This multi-omic analysis of 1,211 colorectal cancer primary tumors reveals that it should be possible to better monitor resistance in the 15% of cases that respond to immune blockade therapy and also to use WNT signaling inhibitors to reverse immune exclusion in the 85% of cases that currently do not. Cancer Discov; 8(6); 730-49. ©2018 AACR. This article is highlighted in the In This Issue feature, p. 663 . ©2018 American Association for Cancer Research.

Correlation of MLH1 and MGMT methylation levels between peripheral blood leukocytes and colorectal tissue DNA samples in colorectal cancer patients.

Science.gov (United States)

Li, Xia; Wang, Yibaina; Zhang, Zuoming; Yao, Xiaoping; Ge, Jie; Zhao, Yashuang

2013-11-01

CpG island methylation in the promoter regions of the DNA mismatch repair gene mutator L homologue 1 ( MLH1 ) and DNA repair gene O 6 -methylguanine-DNA methyltransferase ( MGMT ) genes has been shown to occur in the leukocytes of peripheral blood and colorectal tissue. However, it is unclear whether the methylation levels in the blood leukocytes and colorectal tissue are correlated. The present study analyzed and compared the levels of MGMT and MLH1 gene methylation in the leukocytes of peripheral blood and colorectal tissues obtained from patients with colorectal cancer (CRC). The methylation levels of MGMT and MLH1 were examined using methylation-sensitive high-resolution melting (MS-HRM) analysis. A total of 44 patients with CRC were selected based on the MLH1 and MGMT gene methylation levels in the leukocytes of the peripheral blood. Corresponding colorectal tumor and normal tissues were obtained from each patient and the DNA methylation levels were determined. The correlation coefficients were evaluated using Spearman's rank test. Agreement was determined by generalized κ-statistics. Spearman's rank correlation coefficients (r) for the methylation levels of the MGMT and MLH1 genes in the leukocytes of the peripheral blood and normal colorectal tissue were 0.475 and 0.362, respectively (P=0.001 and 0.016, respectively). The agreement of the MGMT and MLH1 gene methylation levels in the leukocytes of the peripheral blood and normal colorectal tissue were graded as fair and poor (κ=0.299 and 0.126, respectively). The methylation levels of MGMT and MLH1 were moderately and weakly correlated between the patient-matched leukocytes and the normal colorectal tissue, respectively. Blood-derived DNA methylation measurements may not always represent the levels of normal colorectal tissue methylation.

Encontros e confrontos entre a vida e o direito

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Simone Maria Hüning

2014-09-01

Full Text Available Nosso objetivo é discutir os processos de objetivação, desqualificação e criminalização de uma comunidade tradicional de pescadores situada na orla urbana de Maceió, que trava uma luta contra a prefeitura municipal pelo direito à permanência e por investimentos nesse território. Com base nas pesquisas de Michel Foucault, propomos uma problematização dessas formas de objetivação, subjetivação e governo, analisando práticas e saberes que incidem sobre essa comunidade. Usamos registros produzidos em quatro anos de trabalho com essa comunidade, bem como documentos e materiais midiáticos que abordam o conflito. Discutimos a judicialização da vida em torno de dois aspectos: a discursos que operam como condições de possibilidade para sustentar a proposta de remoção dessa comunidade de seu território; b estratégias de resistência que afirmam a especificidade da vida nesse lugar. Trazemos esta situação para o debate sobre a judicialização da vida buscando não apenas problematizar as circunstâncias em que se passa a demandar mais intervenção jurídica no governo da vida, mas também afirmar que o que está em jogo nessa situação não é a mera aplicação e cumprimento da lei, e sim, os modos de vida dessa comunidade que confrontam a lógica de investimento e desenvolvimento urbano da cidade.

Analysis of metastasis associated signal regulatory network in colorectal cancer.

Science.gov (United States)

Qi, Lu; Ding, Yanqing

2018-06-18

Metastasis is a key factor that affects the survival and prognosis of colorectal cancer patients. To elucidate molecular mechanism associated with the metastasis of colorectal cancer, genes related to the metastasis time of colorectal cancer were screened. Then, a network was constructed with this genes. Data was obtained from colorectal cancer expression profile. Molecular mechanism elucidated the time of tumor metastasis and the expression of genes related to colorectal cancer. We found that metastasis-promoting and metastasis-inhibiting networks included protein hubs of high connectivity. These protein hubs were components of organelles. Some ribosomal proteins promoted the metastasis of colorectal cancer. In some components of organelles, such as proteasomes, mitochondrial ribosome, ATP synthase, and splicing factors, the metastasis of colorectal cancer was inhibited by some sections of these organelles. After performing survival analysis of proteins in organelles, joint survival curve of proteins was constructed in ribosomal network. This joint survival curve showed metastasis was promoted in patients with colorectal cancer (P = 0.0022939). Joint survival curve of proteins was plotted against proteasomes (P = 7 e-07), mitochondrial ribosome (P = 0.0001157), ATP synthase (P = 0.0001936), and splicing factors (P = 1.35e-05). These curves indicate that metastasis of colorectal cancer can be inhibited. After analyzing proteins that bind with organelle components, we also found that some proteins were associated with the time of colorectal cancer metastasis. Hence, different cellular components play different roles in the metastasis of colorectal cancer. Copyright © 2018 Elsevier Inc. All rights reserved.

Attributable causes of colorectal cancer in China

OpenAIRE

Gu, Meng-Jia; Huang, Qiu-Chi; Bao, Cheng-Zhen; Li, Ying-Jun; Li, Xiao-Qin; Ye, Ding; Ye, Zhen-Hua; Chen, Kun; Wang, Jian-Bing

2018-01-01

Background Colorectal cancer is the 4th common cancer in China. Most colorectal cancers are due to modifiable lifestyle factors, but few studies have provided a systematic evidence-based assessment of the burden of colorectal cancer incidence and mortality attributable to the known risk factors in China. Methods We estimated the population attributable faction (PAF) for each selected risk factor in China, based on the prevalence of exposure around 2000 and relative risks from cohort studies a...

Qualidade de vida, ponto de partida ou resultado final?

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Alby Duarte Rocha

Full Text Available O que é qualidade de vida e o quanto podemos medir dela? Pensa-se em qualidade de vida como resultado das políticas públicas e desenvolvimento de uma sociedade, onde os determinantes socioambientais se manifestam como atributo de seus atores. Ao mesmo tempo, pode-se entender esta idéia no outro extremo da análise, a partir da percepção de uma população protagonista de sua realidade, do que vem a ser qualidade de vida segundo ela mesma. Partindo-se dos aspectos conceituais de qualidade de vida, passou-se a adotar os conceitos de diferenciais intra-urbanos como a melhor maneira de caracterizar os desajustes e as desigualdades urbanas, para assim entender os componentes da iniqüidade desse meio. A primeira iniciativa marcou a utilização do método genebrino ou distancial. Hoje, já na segunda versão desse método, incorporou-se a esse contexto outras metodologias que possibilitam maior consistência de análise para ampliar a validade dessas medições. Soma-se a esse contexto, a análise de cluster e o Sistema de Informações Geográficas, tanto no cenário intra-urbano, quanto intermunicipal.

A última escolha: repensar a morte em vida

OpenAIRE

Roque, Margarida Abenta

2010-01-01

Tese de mestrado, Filosofia, Universidade de Lisboa, Faculdade de Letras, 2010 A presente dissertação de mestrado em Filosofia, intitulada A última escolha: repensar a morte em vida, consistirá numa análise expositiva de natureza ética das opções de final de vida que se colocam aos indivíduos doentes ou em estado terminal, abstendo-se de juízos de matriz legal ou jurídica. Tomando Peter Singer como autor de referência intelectual nesta dissertação, o nosso ponto de partida cons...

Calidad de vida y discapacidad auditiva en Chile

OpenAIRE

Suazo Díaz, Pilar

2016-01-01

[ES] La pérdida auditiva es una discapacidad sensorial que genera diversas dificultades en el desarrollo biopsicosocial de las personas que la padecen, pudiendo afectar a su calidad de vida. La investigación que se presenta buscó describir y analizar la percepción de calidad de vida (CV) de las personas en situación de discapacidad auditiva de Chile. Para este efecto, se utilizó metodología mixta explicativa secuencial. En el abordaje cuantitativo participaron 102 personas con pérdidas de...

Lower or Standard Dose Regorafenib in Treating Patients With Refractory Metastatic Colorectal Cancer

Science.gov (United States)

2018-03-22

Colon Adenocarcinoma; Rectal Adenocarcinoma; Stage III Colorectal Cancer AJCC v7; Stage IIIA Colorectal Cancer AJCC v7; Stage IIIB Colorectal Cancer AJCC v7; Stage IIIC Colorectal Cancer AJCC v7; Stage IV Colorectal Cancer AJCC v7; Stage IVA Colorectal Cancer AJCC v7; Stage IVB Colorectal Cancer AJCC v7

[Multiple primary colorectal cancer: Clinical aspects].

Science.gov (United States)

Soldatkina, N V; Kit, O I; Gevorkyan, Yu A; Milakin, A G

to define some clinical characteristics of synchronous and metachronous colorectal cancer (CRC). The investigation was concerned with the data of 150 patients with T1-4N0-2M0-1 multiple primary CRC. The clinical, biological, and morphological characteristics of synchronous and metachronous tumors were analyzed. Multiple primary tumors were 6.01% of all the cases of CRC. There was a preponderance of synchronous CRC (63.75%) with the tumor localized in the sigmoid colon and rectum. In women, synchronous colorectal tumors were more often concurrent with breast tumors; metachronous ones were detected after treatment for genital tumors. In men, synchronous colorectal tumors were more frequently concurrent with kidney cancer; metachronous ones were identified after treatment for gastric cancer. The found characteristics of multiple primary colorectal tumors may be taken in account in programs for both primary diagnosis and follow-up after treatment for malignant tumors, which will be able to improve the early detection of cancer patients and their treatment results.

Clinical application and research of tumor markers in colorectal cancer

International Nuclear Information System (INIS)

Chen Yumei

2005-01-01

Colorectal cancer is one of the most common malignant tumors. There are many tumor markers for detecting colorectal cancer, some of which have been widely used in clinical area. However, still lack an ideal tumor marker of colorectal cancer. In this review, we simply characterized some common tumor markers including carcinoembryonic antigen, CA19-9, CA50, CA242 etc and their dignostic value. And here we discussed some combined detecting procedures which improve diagnostic accuracy of colorectal cancer. In addition, with the development of the biomoleculer technique, some newly discovered tumor markers and genetic marekers have gained great progress in the research of colorectal cancer, and will become a promissing technique in the diagnosis of colorectal cancer. (authors)

Brain metastases from colorectal cancer

DEFF Research Database (Denmark)

Vagn-Hansen, Chris Aksel; Rafaelsen, Søren Rafael

2001-01-01

Brain metastases from colorectal cancer are rare. The prognosis for patients with even a single resectable brain metastasis is poor. A case of surgically treated cerebral metastasis from a rectal carcinoma is reported. The brain tumour was radically resected. However, cerebral, as well...... as extracerebral, disease recurred 12 months after diagnosis. Surgical removal of colorectal metastatic brain lesions in selected cases results in a longer survival time....

Pulsiones de Vida y Muerte

Directory of Open Access Journals (Sweden)

Guillermo Sánchez Medina

2001-12-01

Full Text Available

Cuando hacemos alusión a las pulsiones o a su energía, lo estamos haciendo a cargas eléctricas y a partículas subatómicas; así mismo nos referimos a "estímulos endógenos y exógenos", "señales", "excitaciones", "deseos", "necesidades", "afectos y emociones", "transmisiones e impulsos", originados
en los "instintos".
Conocemos desde la perspectiva del psicoanálisis de Freud (en su trabajo sobre Meta psicología en 1915, cómo el instinto es un concepto limítrofe entre lo mental y lo somático, siendo la representación psíquica del estímulo, originado en el organismo que elige la mente.
Por lo tanto los instintos no serían sino la organización de "fuerzas" para la vida y la muerte orgánica, que buscan restablecer un orden y estado de interrelación y movimiento con otras fuerzas (cargas opuestas, antimateria y/o antipartículas, que perturban ese funcionamiento o por el contrario, actúan para conservar el equilibrio y orden; he ahí un concepto proveniente o que nos lleva también a la teoría de la complejidad y caos.
Los instintos (de vida-eros y muerte-tanatos vigilarían el destino de los organismos elementales que sobreviven al individuo total, proporcionándoles un refugio seguro mientras se encuentran indefensos contra los estímulos del mundo externo, y a la vez facilitando su encuentro o nacimiento en la estructura de los nucleótidos del ADN, que son la base biológica del instinto sexual, que preservan la especie y.restablecen un estado previo, el que puede ser la misma involución y la inercia. Todos estos fenómenos no significan que exista una tendencia a la perfección; de aquí que la muerte interna sea también natural como la vida, la que tiene su escape en la ya mencionada supervivencia, defensa y conservación de la especie. De tal forma, la biología no va en contravía de los instintos
de muerte. "Por su parte al reservorio del instinto de vida le damos, en psicoan

PERCEPÇÃO DA QUALIDADE DE VIDA DOS CUIDADORES DE OCTOGENÁRIOS

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Camila Alves Nogueira

2013-01-01

Full Text Available El objetivo fue investigar la percepción de cuidadores de octogenarios acerca de la calidad de vida y aspectos de la vida que más afectan esa calidad. Estudio transversal, descriptivo y cuantitativo, llevado a cabo en 2010 con 52 sujetos, en las unidades de salud de la familia de Campina Grande-PB, Brasil, que respondieron un cuestionario socio-demográfico y el WHOQOL-bref, siendo el análisis efectuado a través del SPSS. El escore total del WHOQOL-bref fue 52,26 pontos. Los aspectos mas comprometidos fueron: vida sexual (94,3%, sentimientos (67,4%, dolor (65,5% y diversión (53,8%; los menos comprometidos fueron: vivienda (82,8%, energía (78,9%, apariencia física (78,9% y relaciones personales (76,9%. La percepción de los cuidadores de octogenarios, acerca de la calidad de vida es marcada por la insatisfacción, lo que lleva a creer que las actividades del atención pueden repercutir negativamente en la vida de los cuidadores.

Prevalence of hereditary nonpolyposis colorectal cancer in patients with colorectal cancer in Iran: a systematic review

Directory of Open Access Journals (Sweden)

Abbas Esmaeilzadeh

2016-07-01

Full Text Available Introduction: Colorectal cancer (CRC is the third leading cause of cancer deaths in the world, and hereditary factors and family history are responsible for the incidence and development of the disease in 20 to 30% of cases. Lynch syndrome, or hereditary nonpolyposis colorectal cancer (HNPCC, is the most common hereditary form of CRC that is inherited in an autosomal dominant manner. This study consisted of a systematic literature review of research articles that described the prevalence of HNPCC in Iranian patients with CRC. Methods: A systematic literature search was conducted in the PubMed, Scopus, IranMedex, and Google Scholar databases to identify relevant articles that describe HNPCC or Lynch syndrome in patients with CRC in Iran. For this purpose, a keyword search of the following terms was employed: (((Hereditary nonpolyposis colorectal cancer OR HNPCC OR Lynch syndrome AND (colorectal cancer OR familial colorectal cancer OR colon cancer OR rectal cancer OR bowel cancer AND IRAN. All eligible documents were collected, and the desired data were qualitatively analyzed.Result: Of the 67 articles that were found via the initial database search, only 12 were deemed to be of relevance to the current study. These articles included a total population of 3237 and this sample was selected and qualitatively analyzed. The findings of the review revealed that the frequency of mutation in MLH1, MSH2, PMS2, and MSH6 genes varied between 23.1% and 62.5% among the studied families. This indicated that HNPCC is linked with up to 5.5% of the total cases of colorectal cancers in Iran.Conclusion: The results of this study revealed that the hereditary form of HNPCC or Lynch syndrome is significantly high among patients with CRC in Iran

Is prevalence of colorectal polyps higher in patients with family history of colorectal cancer?

OpenAIRE

Murad-Regadas, Sthela Maria; Bezerra, Carla Camila Rocha; Peixoto, Ana Ligia Rocha; Regadas, Francisco Sérgio Pinheiro; Rodrigues, Lusmar Veras; Siebra, José Airton Gonçalves; da Silva Fernandes, Graziela Olivia; Vasconcelos, Rafael Aragão

2015-01-01

ABSTRACTObjectives:To assess the prevalence of polyps in patients with a family history of colorectal cancer, in comparison to asymptomatic individuals with indication for screening.Methods:A prospective study in a group of patients who underwent colonoscopy between 2012 and 2014. Patients were divided into two groups: Group I: no family history of colorectal cancer, and Group II: with a family history in first-degree relatives. Demographic characteristics, findings on colonoscopy...

Segundo Premio Nacional de Medicina del Seguro de Vida “Kolnische Ruck”

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Academia Nacional de Medicina

1986-12-01

Full Text Available

Objetivos

Los objetivos básicos de este Premio son los siguientes:

a Estimular la Investigación y el desarrollo de la Medicina del Seguro de Vida en Colombia.
b Promover la tecnificación del Seguro de Vida en Colombia.
c Promover las Investigaciones científicas y estadísticas sobre el Seguro de Vida.
d Contribuir a la popularización del Seguro de Vida.

El Premio se denomina PREMIO NACION AL DE MEDICINA DEL SEGURO DE VIDA “KOLNISCHE RUCK”.

El Premio se otorga cada tres años a partir de 1984. El próximo se entregará en sesión solemne el día 25 ele noviembre de 1987.

Para efectos del otorgamiento de este Premio actuarán como representantes de la Kolnische en Colombia la Asociación de Medicina del Seguro de Vida en Colombia y la Colon en se, Corredores de Reaseguros Ltda.

Los trabajos que aspiren a este Premio deberán ser entregados en las Oficinas de la Colonense en Bogotá (Carrera 15 No. 101A-47, teléfono 2565952 a más tardar el día 27 de Mayo de 1987...

EPIDEMIOLOGICAL EVALUATION OF COLORECTAL CANCER

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B. Shafayan M. Keyhani

2003-07-01

Full Text Available This study was carried out to analyze certain epidemiological variations in Iranian patients with colorectal cancer. (CRC: From March 1981 up to March 1993, 103 patients were analyzed retrospectively for age, gender, marital state, job, nutritional habits, presenting symptoms and histopathological features. Most of the patients with colorectal cancer were male, age range 20-75 (mean 56, 25.4 percent were long-term smokers and bleeding was the most common symptom. The rectum was the most common site and moderately differentiated carcinoma was considered as the main common histopathological variety. In conclusion, increasing incidence of colorectal cancer in younger Iranian population, below 30 and late admission and diagnosis were the main findings in the present study necessitating screening programs with annual fecal occult blood tests in high risk families.

Subnuclear proteomics in colorectal cancer

DEFF Research Database (Denmark)

Albrethsen, Jakob; Knol, Jaco C; Piersma, Sander R

2010-01-01

for early cancer detection. Here we evaluate a proteomics work flow for profiling protein constituents in subnuclear domains in colorectal cancer tissues and apply this work flow to a comparative analysis of the nuclear matrix fraction in colorectal adenoma and carcinoma tissue samples. First, we......Abnormalities in nuclear phenotype and chromosome structure are key features of cancer cells. Investigation of the protein determinants of nuclear subfractions in cancer may yield molecular insights into aberrant chromosome function and chromatin organization and in addition may yield biomarkers...... with statistics, we identified proteins that are significantly enriched in the nuclear matrix fraction relative to two earlier fractions (the chromatin-binding and intermediate filament fractions) isolated from six colorectal tissue samples. The total data set contained 2,059 non-redundant proteins. Gene ontology...

Colorectal cancer

International Nuclear Information System (INIS)

Akiba, Suminori

1992-01-01

This paper describes colorectal cancer risk in relation to A-bomb radiation. The RERF Life Span Study has revealed the incidence of colorectal cancer to be significantly high in the group of A-bomb survivors than the control group. With regard to relative risk or excess relative risk, there is no definitive difference among sites in the colon. Risk for colon cancer is found to be linearly increased with increasing radiation doses, and in younger A-bomb survivors at the time of exposure. Risk associated with one Gy is estimated to be increased by double. There is no definitive variation between sex and between Hiroshima and Nagasaki. Excess relative risk would be increased rapidly with aging in the whole group of A-bomb survivors and with the cancer-prone age in younger A-bomb survivors at the time of exposure. (N.K.)

Recubrimiento comestible de quitosano, almidón de yuca y aceite esencial de canela para conservar pera (Pyrus communis L. cv. “Bosc”)

OpenAIRE

Castro García, Marlon Reinaldo; Espinoza Posligua, Vanessa Gabriela; López Mantuano, Mario Henry; Molina Basurto, Ramón; García Montes, Yessenia Maribel; Lavayen Delgado, Edison Grego

2017-01-01

Las tecnologías de conservación de alimentos son esenciales en la alimentación humana por lo cual es fundamental utilizar técnicas de conservación sanas y seguras para los consumidores. Los frutos de pera (Pyrus communis) confieren un importante aporte nutricional, sin embargo, su vida útil es limitada al ser susceptibles a daños físicos, así como al deterioro microbiológico, frente a lo cual esta investigación evalúa el efecto de recubrimientos comestibles a base de quitosano y almidón de yu...

La magia de Plaza Sésamo IV

OpenAIRE

Revista Chasqui

2015-01-01

Con el apoyo de UNICEF y de TELEVISA- México, se ha conformado un equipo, "Taller de televisión para niños" para diseñar la IV Etapa de Plaza Sésamo, serie de televisión educativa para niños de 3 a 6 años de la América Latina. Este programa ha sido diseñado y producido para estimular el desarrollo de destrezas fundamentales de los pequeños televidentes, preparándoles así para un buen desarrollo en la escuela y proveerlos de actitudes sanas y productivas para su vida futura.

Revisión internacional e iberoamericana del currículum de educación física: El caso de México

OpenAIRE

García Garduño, José María; Del Basto Sabogal, Liliana M.

2017-01-01

A nivel mundial se vive una epidemia de obesidad adulta e infantil. México ocupa el primer lugar mundial en obesidad infantil y el segundo en obesidad adulta. Ante los problemas de salud, el curriculum de Educación física cada vez tiene mayores responsabilidades en el combate a la obesidad y promoción de una vida sana. El propósito de este trabajo fue identificar las tendencias curriculares de la Educación física en el medio internacional y analizar cómo se han incorporado en los objetivos de...

Qualidade de vida: percepção de enfermeiros numa abordagem qualitativa.

Directory of Open Access Journals (Sweden)

Gisélia Alves Araújo

2009-09-01

Full Text Available Essa investigação teve como objetivos verificar o significado de qualidade de vida para os enfermeiros do HospitalUniversitário Lauro Wanderley (HULW; verificar a percepção dos enfermeiros quanto a sua QV e identificar fatoresque interferem na QV desses profissionais. O estudo do tipo exploratório-descritivo com enfoque qualitativo foirealizado no HULW de João Pessoa - PB. A amostra constituiu-se de 12 enfermeiros da área hospitalar. A coleta dedados ocorreu no mês de março de 2006, após aprovação do Comitê de Ética. Utilizou-se um questionário para acoleta dos dados e, para a análise desses dados, utilizou-se a técnica do Discurso do Sujeito Coletivo, que possibilitoua obtenção dos seguintes resultados para a formação das idéias centrais: um estado de harmonia, de vida equilibradano âmbito bio-psico-sócio-espiritual; vida digna; péssima qualidade de vida pelo acúmulo de atividades; boa qualidadede vida, por poder conciliar várias coisas necessárias a essa qualidade; fator financeiro, excesso de trabalho, cobrançado mercado de trabalho interferindo na relação familiar; as dificuldades do cotidiano. Concluímos tornar-se necessárioque, na atuação do enfermeiro, exista a preocupação de equilibrar as condições de trabalho e de vida pessoal em prolda satisfação de sua qualidade de vida.

Management of colorectal cancer and diabetes.

Science.gov (United States)

Yao, Caroline; Nash, Guy F; Hickish, Tamas

2014-03-01

Colorectal cancer is associated with diabetes mellitus and both of these common conditions are often managed together by a surgeon. The surgical focus is usually upon cancer treatment rather than diabetes management. The relationship between colorectal cancer and diabetes is a complex one and can raise problems in both diagnosis and the management of patients with both conditions. This literature review explores the relationship between diabetes, diabetic treatment and colorectal cancer and addresses the issues that arise in diagnosing and treating this patient group. By highlighting these difficulties, this review aims to improve understanding and to provide clearer insight into both surgical and non-surgical management.

Periostin Expression and Its Prognostic Value for Colorectal Cancer

Directory of Open Access Journals (Sweden)

Zewu Li

2015-05-01

Full Text Available Integrin is important for cell growth, invasion and metastasis, which are frequently observed in malignant tumors. The periostin (POSTN gene encodes the ligand for integrin, one of the key focal adhesion proteins contributing to the formation of a structural link between the extracellular matrix and integrins. High expression levels of the POSTN gene are correlated with numerous human malignancies. We examined POSTN protein in colorectal cancer specimens from 115 patients by strictly following up using immunohistochemistry. Cytoplasm immunohistochemical staining showed POSTN protein expression in colorectal cancers. The positive expression rate of POSTN protein (59.13%, 68/115 in colorectal cancers was significantly higher than that in adjacent normal colon mucosa (0.47%, 11/109. POSTN over-expression in colorectal cancers was positively correlated with tumor size, differentiation, lymph node metastasis, serosal invasion, clinical stage and five-year survival rates. Further analysis showed that patients with advanced stage colorectal cancer and high POSTN expression levels had lower survival rates than those with early stage colorectal cancer and low POSTN expression levels. Overall, our results showed that POSTN played an important role in the progression of colorectal cancers.

Management of Colorectal Trauma

Science.gov (United States)

2011-01-01

Although the treatment strategy for colorectal trauma has advanced during the last part of the twentieth century and the result has improved, compared to other injuries, problems, such as high septic complication rates and mortality rates, still exist, so standard management for colorectal trauma is still a controversial issue. For that reason, we designed this article to address current recommendations for management of colorectal injuries based on a review of literature. According to the reviewed data, although sufficient evidence exists for primary repair being the treatment of choice in most cases of nondestructive colon injuries, many surgeons are still concerned about anastomotic leakage or failure, and prefer to perform a diverting colostomy. Recently, some reports have shown that primary repair or resection and anastomosis, is better than a diverting colostomy even in cases of destructive colon injuries, but it has not fully established as the standard treatment. The same guideline as that for colonic injury is applied in cases of intraperitoneal rectal injuries, and, diversion, primary repair, and presacral drainage are regarded as the standards for the management of extraperitoneal rectal injuries. However, some reports state that primary repair without a diverting colostomy has benefit in the treatment of extraperitoneal rectal injury, and presacral drainage is still controversial. In conclusion, ideally an individual management strategy would be developed for each patient suffering from colorectal injury. To do this, an evidence-based treatment plan should be carefully developed. PMID:21980586

Systems Support Mapping in Guiding Self-Management in Stage I-III Colorectal Cancer Survivors

Science.gov (United States)

2018-04-26

Cancer Survivor; Stage I Colorectal Cancer AJCC v8; Stage II Colorectal Cancer AJCC v8; Stage IIA Colorectal Cancer AJCC v8; Stage IIB Colorectal Cancer AJCC v8; Stage IIC Colorectal Cancer AJCC v8; Stage III Colorectal Cancer AJCC v8; Stage IIIA Colorectal Cancer AJCC v8; Stage IIIB Colorectal Cancer AJCC v8; Stage IIIC Colorectal Cancer AJCC v8

El estudio de la satisfacción con la vida

NARCIS (Netherlands)

R. Veenhoven (Ruut)

1994-01-01

textabstractSummary in Spanish:
El tema de la satisfacción con la vida ha sido por largo tiempo un campo de juegos para la especulación filosófica. Por la falta de medidas válidas de la satisfacción con la vida, las proposiciones sobre este asunto no podían ser comprobadas empíricamente. Por

Colorectal Anastomoses : Surgical outcome and prevention of anastomotic leakage

NARCIS (Netherlands)

Bakker, Ilsalien

2016-01-01

Colorectal surgery is a frequently performed procedure with more than 10.000 annual resections in the Netherlands. The majority of resections are performed for colorectal cancer. The first part of this thesis focused on outcome of colorectal cancer surgery in the Netherlands based on the nationwide

Tres enfoques Deontológicos Acerca de la Vida

Directory of Open Access Journals (Sweden)

Edgar Antonio López

2007-01-01

Full Text Available Este artículo presenta tres aproximaciones deontológicas a algunos problemas referidos al comienzo, el fin y la reproducción de la vida humana, así como a la preservación de la vida -humana y no humana- en el planeta. En primer lugar se presenta la deontología clásica de Kant y luego las deontologías contemporáneas de Hans Jonas y de Jürgen Habermas.

Radioimmunodetection of colorectal cancer, using anti-CEA monoclonal antibodies

International Nuclear Information System (INIS)

Murayama, Hiroki; Watanabe, Tadashi; Tadokoro, Masanori; Takagi, Hiroshi; Sakuma, Sadayuki; Sakamoto, Junichi.

1989-01-01

Aiming at radioimmunodetection of colorectal cancer, anti-CEA monoclonal antibodies (CEA102) were produced by immunization with purified CEA. CEA102 showed high specificity with clorectal cancer by mixed hemadsorption assay and immunoperoxidase technique. The antigen detected by CEA102 was confirmed to be carcinoembryonic antigen (CEA) and its molecular weight was estimated to be ca. 180,000 by biochemical analysis. The in vivo study using nude mice grafted a human colorectal cancer or a human malignant melanoma showed greater accumulation of 125 I-labeled CEA102 in CEA-positive colorectal cancer than in nude mouse tissues and CEA-negative malignant melanoma. Moreover we successfully obtained scans with good localization of the grafted colorectal cancer on FCR (Fuji Computed Radiography). Using 131 I-labeled CEA102 liver metastasis in the patient with colorectal cancer was successfully detected by external scanning with γ-camera. These results suggest that radiolabeled CEA102 is useful for the detection of colorectal cancer. (author)

Meat-related compounds and colorectal cancer risk by anatomical subsite.

Science.gov (United States)

Miller, Paige E; Lazarus, Philip; Lesko, Samuel M; Cross, Amanda J; Sinha, Rashmi; Laio, Jason; Zhu, Jay; Harper, Gregory; Muscat, Joshua E; Hartman, Terryl J

2013-01-01

Since meat may be involved in the etiology of colorectal cancer, associations between meat-related compounds were examined to elucidate underlying mechanisms in a population-based case-control study. Participants (989 cases/1,033 healthy controls) completed a food frequency questionnaire with a meat-specific module. Multivariable logistic regression was used to examine associations between meat variables and colorectal cancer; polytomous logistic regression was used for subsite-specific analyses. The following significant positive associations were observed for meat-related compounds: 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and colorectal, distal colon, and rectal tumors; 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and colorectal and colon cancer tumors; nitrites/nitrates and proximal colon cancer; 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and rectal cancer; and benzo[a]pyrene and rectal cancer (P-trends cancer and pan-fried red meat and colorectal cancer were found (P-trends cancer; and well-done/charred poultry and colorectal, colon, and proximal colon tumors (P-trends nitrates may be involved in colorectal cancer etiology. Further examination into the unexpected inverse associations between poultry and colorectal cancer is warranted.

Colorectal Cancer: The Importance of Early Detection

Science.gov (United States)

... of this page please turn JavaScript on. Feature: Colorectal Cancer The Importance of Early Detection Past Issues / Summer ... Cancer of the colon or rectum is called colorectal cancer. The colon and the rectum are part of ...

Prospective study of blood metabolites associated with colorectal cancer risk.

Science.gov (United States)

Shu, Xiang; Xiang, Yong-Bing; Rothman, Nathaniel; Yu, Danxia; Li, Hong-Lan; Yang, Gong; Cai, Hui; Ma, Xiao; Lan, Qing; Gao, Yu-Tang; Jia, Wei; Shu, Xiao-Ou; Zheng, Wei

2018-02-26

Few prospective studies, and none in Asians, have systematically evaluated the relationship between blood metabolites and colorectal cancer risk. We conducted a nested case-control study to search for risk-associated metabolite biomarkers for colorectal cancer in an Asian population using blood samples collected prior to cancer diagnosis. Conditional logistic regression was performed to assess associations of metabolites with cancer risk. In this study, we included 250 incident cases with colorectal cancer and individually matched controls nested within two prospective Shanghai cohorts. We found 35 metabolites associated with risk of colorectal cancer after adjusting for multiple comparisons. Among them, 12 metabolites were glycerophospholipids including nine associated with reduced risk of colorectal cancer and three with increased risk [odds ratios per standard deviation increase of transformed metabolites: 0.31-1.98; p values: 0.002-1.25 × 10 -10 ]. The other 23 metabolites associated with colorectal cancer risk included nine lipids other than glycerophospholipid, seven aromatic compounds, five organic acids and four other organic compounds. After mutual adjustment, nine metabolites remained statistically significant for colorectal cancer. Together, these independently associated metabolites can separate cancer cases from controls with an area under the curve of 0.76 for colorectal cancer. We have identified that dysregulation of glycerophospholipids may contribute to risk of colorectal cancer. © 2018 UICC.

As expectativas de equilíbrio entre vida laboral e vida privada e as escolhas laborais da nova geração

OpenAIRE

Golik, Mariela

2013-01-01

La Generación Y se destaca por sus creencias, aspiraciones y actitudes diferentes a las de las generaciones precedentes. Este estudio explora las expectativas de esta generación con respecto al balance vida laboral y vida privada, examinando la influencia de los padres y el género, y su impacto sobre las elecciones laborales. Mediante un cuestionario auto-administrado se interrogó una muestra de 217 universitarios de pregrado. Se encontró que los jóvenes Y privilegian los aspectos intrínsecos...

Asumiendo juntos los retos: calidad de vida en familias de jóvenes con discapacidad intelectual

Directory of Open Access Journals (Sweden)

Viviana Aya Gómez

2013-04-01

Full Text Available Antecedentes. La calidad de vida familiar se ha convertido enun área de creciente interés en los años recientes.Objetivo. Describir y comprender la calidad de vida de 18familias de jóvenes con discapacidad intelectual en Bogotá,Colombia.Material y métodos. Estudio mixto a través de la Escala deCalidad de Vida Familiar y entrevistas semiestructuradas, paraconstruir con cada familia el Mapa de Calidad de Vida Familiar.Resultados. Los factores de calidad de vida familiar fueronvalorados como fortaleza, con excepción del factor apoyo a lapersona con discapacidad. Se hallaron diferencias significativasentre las variables de estudio.Conclusión. Las familias de jóvenes con discapacidad intelectualdisfrutan de sus vidas juntas y tienen proyectos de vida afuturo. No obstante, su calidad de vida se ve influenciada porla sobreprotección de algunos familiares hacia los jóvenes condiscapacidad intelectual, el desconocimiento de sus derechos ylos escasos apoyos y oportunidades de inclusión social, con losque cuentan actualmente.

Temporal relationship between prostate brachytherapy and the diagnosis of colorectal cancer

International Nuclear Information System (INIS)

Gutman, Sarah A.; Merrick, Gregory S.; Butler, Wayne M.; Wallner, Kent E.; Allen, Zachariah A.; Galbreath, Robert W.; Adamovich, Edward

2006-01-01

Purpose: To identify the location of pretreatment and posttreatment colorectal malignancies and posttreatment colorectal polyps in patients with clinically localized prostate cancer managed with brachytherapy. Methods and Materials: From April 1995 through July 2004, 1,351 consecutive patients underwent brachytherapy for clinical stage T1b-T3a (American Joint Committee on Cancer, 2002) prostate cancer. Supplemental external beam radiotherapy (XRT) was administered to 699 patients. The median follow-up was 4.6 years. Operative and pathology reports were reviewed for all patients with pretreatment and posttreatment colorectal cancer and posttreatment colorectal polyps. Multiple parameters were evaluated for the development of colorectal cancer or colorectal polyps. Results: Colorectal cancer was diagnosed in 23 and 25 patients before and after prostate brachytherapy, respectively. No differences were identified in the distribution of colorectal cancers either before or after treatment (3 and 4 rectal cancers in the pre- and postbrachytherapy cohorts). Thirty-five of the 48 colorectal cancers (73%) were diagnosed within 5 years of brachytherapy with a peak incidence 1 year after brachytherapy. One hundred ninety-two colorectal polyps were diagnosed after brachytherapy, 160 (83%) occurred within 4 years of brachytherapy, and only 27 (14%) were located in the rectum. In multivariate Cox regression analysis, prostate D 9 (minimum percentage of the dose covering 90% of the target volume) predicted for posttreatment colorectal cancer. Rectal polyps were most closely related to patient age and percent positive biopsies, whereas sigmoid/colon polyps were best predicted by patient age, planning volume, and supplemental XRT. Conclusions: Colorectal cancer was diagnosed with equal frequency before and after brachytherapy with comparable geographic distributions. In addition, the vast majority of postbrachytherapy colorectal polyps were located beyond the confines of the rectum

Valoración enfermera y calidad de vida en los cuidados domiciliarios

OpenAIRE

Puig Llobet, Montserrat; Rodríguez Ávila, Núria

2009-01-01

El impacto de una enfermedad o tratamiento, los efectos resultantes de una alteración en la forma de vida del individuo y la valoración subjetiva del propio individuo son conceptos relacionados con calidad de vida y salud. Las valoraciones enfermeras aportan información valiosa sobre la calidad de vida de los mayores dependientes porque presumiblemente se preocupan de la satisfacción de las necesidades de la persona dependiente y su cuidador. El objetivo de este estudio fue conocer la percepc...

The COLON study: Colorectal cancer: Longitudinal, Observational study on Nutritional and lifestyle factors that may influence colorectal tumour recurrence, survival and quality of life

OpenAIRE

Winkels, R.M.; Heine-Bröring, R.C.; Zutphen, van, M.; Harten-Gerritsen, van, A.S.; Kok, D.E.G.; Duijnhoven, van, F.J.B.; Kampman, E.

2014-01-01

BACKGROUND: There is clear evidence that nutrition and lifestyle can modify colorectal cancer risk. However, it is not clear if those factors can affect colorectal cancer treatment, recurrence, survival and quality of life. This paper describes the background and design of the "COlorectal cancer: Longitudinal, Observational study on Nutritional and lifestyle factors that may influence colorectal tumour recurrence, survival and quality of life" - COLON - study. The main aim of this study is to...

Minilaparoscopic Colorectal Resections: Technical Note

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S. Bona

2012-01-01

Full Text Available Laparoscopic colorectal resections have been shown to provide short-term advantages in terms of postoperative pain, general morbidity, recovery, and quality of life. To date, long-term results have been proved to be comparable to open surgery irrefutably only for colon cancer. Recently, new trends keep arising in the direction of minimal invasiveness to reduce surgical trauma after colorectal surgery in order to improve morbidity and cosmetic results. The few reports available in the literature on single-port technique show promising results. Natural orifices endoscopic techniques still have very limited application. We focused our efforts in standardising a minilaparoscopic technique (using 3 to 5 mm instruments for colorectal resections since it can provide excellent cosmetic results without changing the laparoscopic approach significantly. Thus, there is no need for a new learning curve as minilaparoscopy maintains the principle of instrument triangulation. This determines an undoubted advantage in terms of feasibility and reproducibility of the procedure without increasing operative time. Some preliminary experiences confirm that minilaparoscopic colorectal surgery provides acceptable results, comparable to those reported for laparoscopic surgery with regard to operative time, morbidity, and hospital stay. Randomized controlled studies should be conducted to confirm these early encouraging results.

Wound Disruption Following Colorectal Operations.

Science.gov (United States)

Moghadamyeghaneh, Zhobin; Hanna, Mark H; Carmichael, Joseph C; Mills, Steven; Pigazzi, Alessio; Nguyen, Ninh T; Stamos, Michael J

2015-12-01

Postoperative wound disruption is associated with high morbidity and mortality. We sought to identify the risk factors and outcomes of wound disruption following colorectal resection. The American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database was used to examine the clinical data of patients who underwent colorectal resection from 2005 to 2013. Multivariate regression analysis was performed to identify risk factors of wound disruption. We sampled a total of 164,297 patients who underwent colorectal resection. Of these, 2073 (1.3 %) had wound disruption. Patients with wound disruption had significantly higher mortality (5.1 vs. 1.9 %, AOR: 1.46, P = 0.01). The highest risk of wound disruption was seen in patients with wound infection (4.8 vs. 0.9 %, AOR: 4.11, P disruption such as chronic steroid use (AOR: 1.71, P disruption compared to open surgery (AOR: 0.61, P disruption occurs in 1.3 % of colorectal resections, and it correlates with mortality of patients. Wound infection is the strongest predictor of wound disruption. Chronic steroid use, obesity, severe COPD, prolonged operation, non-elective admission, and serum albumin level are strongly associated with wound disruption. Utilization of the laparoscopic approach may decrease the risk of wound disruption when possible.

Riesgo cardiovascular, calidad de Vida y años de vida ajustados por calidad: un estudio de caso Risco cardiovascular, qualidade de vida e anos de vida ajustados por qualidade: um estudo de caso Cardiovascular risk, quality of life and quality-adjusted years of life: a case report

Directory of Open Access Journals (Sweden)

Sandra Lorena Duque Henao

2010-03-01

Full Text Available Objetivo: determinar la razón costo-utilidad de un programa de promoción y prevención de enfermedades cardiovasculares (ECV en una institución que presta servicios de salud en la ciudad de Medellín (Colombia. Metodología: se comparó el programa preventivo con el esquema de control convencional bajo el diseño de un estudio cuasiexperimental de evaluación antes y después con grupo control no equivalente. Entre los grupos de estudio se evaluaron diferencias al final del primero y segundo año de los siguientes resultados: puntaje de Framingham, costo directo para el programa, calidad de vida, índice de salud y años de vida ajustados por calidad. Resultados: entre los grupos evaluados se encontró diferencia estadísticamente significante entre los momentos inicial y final para las variables: puntaje de Framingham, índice de salud y años de vida ajustados por calidad. Conclusión: la participación de los pacientes en programa de promoción y prevención de ECV está relacionado con reducción en el riesgo y mejoría en la calidad de vida.Objetivo: determinar a razão custo-utilidade de um programa de promoção e prevenção de doenças cardiovasculares (ECV numa instituição que presta serviços de saúde na cidade de Medellín (Colômbia. Metodologia: comparou-se o programa preventivo com o esquema de controle convencional sob o desenho de um estudo quase-experimental de avaliação antes e depois com grupo controle não equivalente. Entre os grupos de estudo se avaliaram diferenças ao final do primeiro e segundo ano dos seguintes resultados: pontuação de Framingham, custo direto para o programa, qualidade de vida, índice de saúde e anos de vida ajustados por qualidade. Resultados: entre os grupos avaliados se encontrou diferença estatisticamente significante entre os momentos inicial e final para as variáveis: pontuação de Framingham, índice de saúde e anos de vida ajustados por qualidade. Conclusão: a participa

Personalidades vocacionais e processos de carreira na vida adulta

OpenAIRE

Magalhães, Mauro de Oliveira; Gomes, William B.

2007-01-01

Esta pesquisa abordou a relação entre interesses vocacionais e os processos de comprometimento e entrincheiramento na carreira em diferentes fases da vida. Uma amostra de 733 profissionais (415 homens e 318 mulheres) respondeu a medidas de comprometimento e de entrincheiramento na carreira. Os sujeitos foram categorizados de acordo com o interesse vocacional predominante na tipologia de Holland. As análises revelaram interação entre estágio de vida e personalidade vocacional para os escores d...

Una biografía inmoral: La vida de Aldao

OpenAIRE

Manzoni, Celina

2011-01-01

Las escrituras del yo, cuyo valor documental es innegable en la cultura americana del siglo XIX, realizan en Sarmiento un peculiar deslizamiento entre lo autobiográfico y lo biográfico. Los pasa- jes desde la escritura de la propia vida, que lee- mos en Mi defensa de 1843 y en Viajes de 1849, a la escritura de la vida de los otros (en Aldao y Facundo , ambos de 1845), parecen culminar en Recuerdos de provincia que logra reunir los dos mov...

Un orden urbano: Paisaje, calidad de vida y sustentabilidad

OpenAIRE

Hans Fox Timmling

2008-01-01

La calidad de vida regional representa entonces un conjunto de metas por medio de las cuales las sociedades se aseguran que las transformaciones territoriales y espaciales proporcionen una mejor existencia a sus habitantes, tanto de la sociedad como también la sustentabilidad de todos los procesos naturales que fundamentan la vida social en una región. Los Planes de Ordenamiento Territorial, ciertamente han de enmarcarse en esta meta más general de aumentar la calidad de vid...

O cuidar da pessoa em fim de vida como experiência formadora El cuidado de una persona durante el fin de vida como experiencia formativa Care of a dying person as a development experience

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Cidália Frias

2012-01-01

Full Text Available Este artigo exige uma reflexão sobre a aprendizagem do cuidar na morte, centrada na pessoa do enfermeiro. A metodologia que orientou o estudo foi de caráter qualitativo e utilizamos a técnica de análise de conteúdo. Mobiliza como material empírico, o conteúdo de oito entrevistas efetuadas a enfermeiros que exercem sua atividade profissional nos Serviços de Hospitalização, com pessoas em fim de vida. As linhas orientadoras são: compreender como a história de vida do enfermeiro influencia o processo de cuidar do moribundo; compreender como os enfermeiros vivenciam o processo de morrer e como o cuidado da pessoa em fim de vida revela a essência do próprio momento de cuidar. Os temas encontrados foram: a vida por um fo; uma vida que caminha ao seu final; a vida e a morte se uniram e a aprendizagem do cuidado da pessoa em fim de vida. Os enfermeiros consideraram que a pessoa em fim de vida é um ser em relação e que o contexto influencia a forma como estão com ela. Perspectiva de uma formação que privilegia novas formas de estar com a pessoa em fim de sua existência.Este artículo exige una reflexión sobre el aprendizaje del cuidado de personas moribundas, centrada en la persona del enfermero. La metodología que orientó el estudio fue de carácter cualitativo y se utilizó la técnica de análisis de contenido. El trabajo utiliza como material empírico, el contenido de ocho entrevistas efectuadas a enfermeros que ejercen su actividad profesional en los servicios de hospitalización, con personas en fin de vida. Las líneas orientadoras son: comprender como la historia de la vida del enfermero influye en el proceso de cuidado de personas moribundas; comprender como los enfermeros viven el proceso de la muerte y como el cuidado de personas en fin de vida revela la esencia del propio momento de cuidado. Los temas encontrados fueron: la vida en un hilo; una vida que camina hacia el fin; la vida y la muerte se unieron y el

Inflammatory bowel disease and colorectal cancer

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Andreja Ocepek

2006-12-01

Full Text Available Background: Colorectal cancer is one of the most frequent cancers in developed countries and Slovenia, and the incidence is still rising. Groups of people with higher risk for colorectal cancer are well defined. Among them are patients with inflammatory bowel disease. The risk is highest in patients in whom whole large bowel is affected by inflammation, it rises after 8 to 10 years and increases with the duration of the disease. Precancerous lesion is a displastic, chronically inflammed mucosa and not an adenoma as in cases of sporadic colorectal carcinoma.Conclusions: Many studies suggest that the influence of genetic factors differs between sporadic and inflammatory bowel disease related colorectal cancer. Symptomatic patients at the time of diagnosis have a much worse prognosis. The goal of prevention programes is therefore discovering early precancerous lesions. Established screening protocols are based on relatively frequent colonoscopies which are inconvinient for the patient as well as the endoscopist. Use of specific genetic markers, mutations of candidate genes, as a screening method and a prognostic predictor could greatly lighten therapeutic decisions.

História de vida e comportamento de risco em amostra brasileira

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Rachel Coelho Ripardo

2012-01-01

Full Text Available Las consecuencias de los comportamientos de riesgo en los países en desarrollo requieren un análisis complejo, incluyendo múltiples variables, tales como la historia de vida. Edad, estado civil y parental y expectativa subjetiva de vida pueden moderar la percepción de un comportamiento arriesgado y atracción a él. Así, la investigación está orientada a identificar las influencias de los factores de la historia de vida en las conductas de riesgo en Brasil. La escala Risk-propensity Scale se aplicó en 358 participantes mayores de 18 años. Como resultado, las dimensiones Percepción y "Atractividad" sufrieron el impacto del contexto y de la historia de vida. En general, los más jóvenes, solteros, sin hijos y los que esperaban vivir menos tendieron a percibir los comportamientos como menos arriesgados y a arriesgarse más. Estos resultados son congruentes con la perspectiva evolucionista del ciclo de vida, que somete las disposiciones comportamentales a las prioridades de cada edad: crecimiento, reproducción y mantenimiento.

Familial colorectal cancer type X

DEFF Research Database (Denmark)

Dominguez-Valentin, Mev; Therkildsen, Christina; Da Silva, Sabrina

2015-01-01

Heredity is a major cause of colorectal cancer, but although several rare high-risk syndromes have been linked to disease-predisposing mutations, the genetic mechanisms are undetermined in the majority of families suspected of hereditary cancer. We review the clinical presentation, histopathologic...... features, and the genetic and epigenetic profiles of the familial colorectal cancer type X (FCCTX) syndrome with the aim to delineate tumor characteristics that may contribute to refined diagnostics and optimized tumor prevention....

Linking Gut Microbiota to Colorectal Cancer

DEFF Research Database (Denmark)

Raskov, Hans; Burcharth, Jakob; Pommergaard, Hans-Christian

2017-01-01

Pre-clinical and clinical data produce mounting evidence that the microbiota is strongly associated with colorectal carcinogenesis. Dysbiosis may change the course of carcinogenesis as microbial actions seem to impact genetic and epigenetic alterations leading to dysplasia, clonal expansion...... and malignant transformation. Initiation and promotion of colorectal cancer may result from direct bacterial actions, bacterial metabolites and inflammatory pathways. Newer aspects of microbiota and colorectal cancer include quorum sensing, biofilm formation, sidedness and effects/countereffects of microbiota...... and probiotics on chemotherapy. In the future, targeting the microbiota will probably be a powerful weapon in the battle against CRC as gut microbiology, genomics and metabolomics promise to uncover important linkages between microbiota and intestinal health....

Asumiendo juntos los retos: calidad de vida en familias de jóvenes con discapacidad intelectual

OpenAIRE

Viviana Aya Gómez; Leonor Córdoba

2013-01-01

Antecedentes. La calidad de vida familiar se ha convertido enun área de creciente interés en los años recientes.Objetivo. Describir y comprender la calidad de vida de 18familias de jóvenes con discapacidad intelectual en Bogotá,Colombia.Material y métodos. Estudio mixto a través de la Escala deCalidad de Vida Familiar y entrevistas semiestructuradas, paraconstruir con cada familia el Mapa de Calidad de Vida Familiar.Resultados. Los factores de calidad de vida familiar fueronvalorados como f...

Importance of PET/CT for imaging of colorectal cancer

International Nuclear Information System (INIS)

Meinel, F.G.; Schramm, N.; Graser, A.; Reiser, M.F.; Rist, C.; Haug, A.R.

2012-01-01

Fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) has emerged as a very useful imaging modality in the management of colorectal carcinoma. Data from the literature regarding the role of PET/CT in the initial diagnosis, staging, radiotherapy planning, response monitoring and surveillance of colorectal carcinoma is presented. Future directions and economic aspects are discussed. Computed tomography (CT), magnetic resonance imaging (MRI) and FDG-PET for colorectal cancer and endorectal ultrasound for rectal cancer. Combined FDG-PET/CT. While other imaging modalities allow superior visualization of the extent and invasion depth of the primary tumor, PET/CT is most sensitive for the detection of distant metastases of colorectal cancer. We recommend a targeted use of PET/CT in cases of unclear M staging, prior to metastasectomy and in suspected cases of residual or recurrent colorectal carcinoma with equivocal conventional imaging. The role of PET/CT in radiotherapy planning and response monitoring needs to be determined. Currently there is no evidence to support the routine use of PET/CT for colorectal screening, staging or surveillance. To optimally exploit the synergy between morphologic and functional information, FDG-PET should generally be performed as an integrated FDG-PET/CT with a contrast-enhanced CT component in colorectal carcinoma. (orig.) [de

Vitamin D, inflammation, and colorectal cancer progression

NARCIS (Netherlands)

Harten-Gerritsen, van Suzanne; Balvers, Michiel G.J.; Witkamp, Renger F.; Kampman, Ellen; Duijnhoven, van F.J.B.

2015-01-01

Survival from colorectal cancer is positively associated with vitamin D status. However, whether this association is causal remains unclear. Inflammatory processes may link vitamin D to colorectal cancer survival, and therefore investigating inflammatory markers as potential mediators may be a

The somatic mutation landscape of premalignant colorectal adenoma.

Science.gov (United States)

Lin, Shu-Hong; Raju, Gottumukkala S; Huff, Chad; Ye, Yuanqing; Gu, Jian; Chen, Jiun-Sheng; Hildebrandt, Michelle A T; Liang, Han; Menter, David G; Morris, Jeffery; Hawk, Ernest; Stroehlein, John R; Futreal, Andrew; Kopetz, Scott; Mishra, Lopa; Wu, Xifeng

2017-06-12

There are few studies which characterised the molecular alterations in premalignant colorectal adenomas. Our major goal was to establish colorectal adenoma genome atlas and identify molecular markers of progression from colorectal adenoma to adenocarcinoma. Whole-exome sequencing and targeted sequencing were carried out in 149 adenoma samples and paired blood from patients with conventional adenoma or sessile serrated adenoma to characterise the somatic mutation landscape for premalignant colorectal lesions. The identified somatic mutations were compared with those in colorectal cancer (CRC) samples from The Cancer Genome Atlas. A supervised random forest model was employed to identify gene panels differentiating adenoma from CRC. Similar somatic mutation frequencies, but distinctive driver mutations, were observed in sessile serrated adenomas and conventional adenomas. The final model included 20 genes and was able to separate the somatic mutation profile of colorectal adenoma and adenocarcinoma with an area under the curve of 0.941. The findings of this project hold potential to better identify patients with adenoma who may be candidates for targeted surveillance programmes and preventive interventions to reduce the incidence of CRC. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

El maestro como formador y cultor de la vida

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Nahyr Remolina De Cleves

2004-01-01

Full Text Available El presente artículo describe y reflexiona sobre el proceso histórico del quehacer pedagógico y los aspectos fundamentales del maestro como formador y cultor de vida, desde la antigüedad hasta los albores del siglo XXI. El maestro auténtico posee unas características esenciales que lo distinguen como líder, formador y forjador de personas, potenciador de saberes y valores que coadyuvan al desarrollo humano. No sólo enseña contenidos e instruye sino que educa con las actitudes y ejemplos de vida. Se presentan aquí las cualidades del maestro integral en que se conjugan el conocimiento científico, las virtudes intelectuales, el sentido humanista, la visión prospectiva, creadora y transformadora, la defensa de la verdad y de la vida, el cultivo de los valores éticos, la edificación innovadora de la cultura y el compromiso permanente de educar para la libertad.

Self-renewal molecular mechanisms of colorectal cancer stem cells.

Science.gov (United States)

Pan, Tianhui; Xu, Jinghong; Zhu, Yongliang

2017-01-01

Colorectal cancer stem cells (CCSCs) represent a small fraction of the colorectal cancer cell population that possess self-renewal and multi-lineage differentiation potential and drive tumorigenicity. Self-renewal is essential for the malignant biological behaviors of colorectal cancer stem cells. While the self-renewal molecular mechanisms of colorectal cancer stem cells are not yet fully understood, the aberrant activation of signaling pathways, such as Wnt, Notch, transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP) and Hedgehog-Gli (HH-GLI), specific roles mediated by cell surface markers and micro-environmental factors are involved in the regulation of self-renewal. The elucidation of the molecular mechanisms behind self-renewal may lead to the development of novel targeted interventions for the treatment of colorectal cancer.

Estilos de vida en estudiantes universitarios

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Martha Muñoz Argel

2013-07-01

Full Text Available Abstract This research paper aims to identify life style based on specific practices and beliefs and to analyze the socio-economical stratum at a university level. The research design is transversal and descriptive and the tool used was the Practices and Beliefs About Life Style Questionnaire. The socioeconomical stratum was established through database entry and an enrollment category assigned by the university. For the sample 180 students were chosen through a random and systematic sampling method. The results show the prevalence of a healthy life style with discrepancies between practices and beliefs. In relation to the socio-economic stratum, differences were not showed. Resumen El presente artículo de investigación tiene como objetivo identificar el estilo de vida a partir de las prácticas y las creencias, así como analizar la variable estrato socioeconómico en el contexto del nivel educativo universitario. El diseño de investigación es transversal descriptivo y el instrumento utilizado fue el Cuestionario de Prácticas y Creencias sobre el Estilo de Vida. El estrato socioeconómico se estableció mediante la base de datos de ingreso y categoría de matrícula asignada por la universidad. La muestra fue constituida por 180 estudiantes universitarios, que fueron seleccionados mediante muestreo aleatorio por conglomerado y sistemático. Los resultados muestran la prevalencia del estilo de vida saludable, con discrepancias entre prácticas y creencias, y en relación con el estrato socioeconómico, no se presentaron diferencias significativas.

Escrituras de la vida cotidiana

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Federico Baeza

2012-07-01

Full Text Available Diversas producciones en las artes visuales y performáticas de la última década, se han puesto como objetivo la constitución de estrategias escriturales,en tanto transcripción y, más precisamente, configuración de experiencias extraídas de la vida de todos los días. Las narraciones alrededor de distintos núcleos del ámbito de la cotidianidad, como la cocina, la conversación o el habitar, entre otros tópicos ya señalados por Michel de Certeau1, aparecen en el centro de estas operaciones que recorren el eje entre la historia reciente como episodio colectivo y la singularidad de las historias de vida volviendo a reivindicar lo personal como político. Dichas operaciones artísticas, que funcionan como ready-mades de experiencias personales, precisan de estrategias de transcripción de las textualidades de la vida cotidiana que incluyen narraciones biográficas, recuerdos, particulares usos de los objetos, entre otras prácticas de las “artes del hacer” cotidiano. Abordaremos estas operaciones escriturarias desde la selección de obras de tres artistas argentinos contemporáneos que inscriben su trabajo en este vasto horizonte de problemáticas cercano a la noción de “espacio biográfico”.2 De la producción de Verónica Gómez nos centraremos fundamentalmente en uno de sus primeros trabajos, Casa Museo (2003-2005, en el que la artista desarrolla diversos procedimientos sobre objetos del recuerdo que parodian lo científico y rememoran juegos infantiles en una institución apócrifa alojada en la casa de sus abuelos. Luego observaremos la obra de Gabriel Baggio cuya producción se centra en la conexión entre historia personal e historia colectiva, en los mecanismos culturales que se ponen en juego al aprender prácticas u oficios de “nuestros mayores”, en el diseño de circuitos de contacto interpersonal y en la observación de las prácticas estéticas de todos los días (cocinar, tejer, habitar. Finalmente nos

The COLON study: Colorectal cancer: Longitudinal, Observational study on Nutritional and lifestyle factors that may influence colorectal tumour recurrence, survival and quality of life

NARCIS (Netherlands)

Winkels, R.M.; Heine-Bröring, R.C.; Zutphen, van M.; Harten-Gerritsen, van A.S.; Kok, D.E.G.; Duijnhoven, van F.J.B.; Kampman, E.

2014-01-01

Background There is clear evidence that nutrition and lifestyle can modify colorectal cancer risk. However, it is not clear if those factors can affect colorectal cancer treatment, recurrence, survival and quality of life. This paper describes the background and design of the “COlorectal cancer:

The COLON study: Colorectal cancer: Longitudinal, Observational study on Nutritional and lifestyle factors that may influence colorectal tumour recurrence, survival and quality of life

NARCIS (Netherlands)

Winkels, R.M.; Heine-Broring, R.C.; Zutphen, M. van; Harten-Gerritsen, S. van; Kok, D.E.; Duijnhoven, F.J.B. van; Kampman, E.

2014-01-01

BACKGROUND: There is clear evidence that nutrition and lifestyle can modify colorectal cancer risk. However, it is not clear if those factors can affect colorectal cancer treatment, recurrence, survival and quality of life. This paper describes the background and design of the "COlorectal cancer:

The Role of Akt Isoforms in Colorectal Cancer

Science.gov (United States)

2015-09-01

AD_________________ Award Number: W81XWH-13-1-0198 TITLE: The Role of Akt Isoforms in Colorectal Cancer PRINCIPAL INVESTIGATOR: Jatin Roper...CONTRACT NUMBER The Role of Akt Isoforms in Colorectal Cancer 5b. GRANT NUMBER W81XWH-13-1-0198 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER...substantially reduces colorectal tumorigenesis in our genetically engineered mouse model. We also successfully ablated novel downstream targets of Akt in our

Pensar a vida

OpenAIRE

Encarnação, José d'

2016-01-01

Texto incluído no catálogo («Mudar de Vida») da exposição permanente da cidade romana de Tongobriga, na intenção de se reconstituir o dia-a-dia dos seus habitantes. E uma das suas ocupações seria orar - e disso se trata neste capítulo. Imagina-se, no âmbito da vivência diária, as intenções de Valerius Paternus ao mandar gravar uma árula à deusa Fortuna e os rituais da sua colocação solene no lararium familiar, da cidade romana de Tongobriga.

GSTT2 promoter polymorphisms and colorectal cancer risk

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Ahn Sun-A

2007-01-01

Full Text Available Abstract Background Glutathione S-transferases are a group of enzymes that participate in detoxification and defense mechanisms against toxic carcinogens and other compounds. These enzymes play an important role in human carcinogenesis. In the present study, we sought to determine whether GSTT2 promoter single nucleotide polymorphisms (SNPs are associated with colorectal cancer risk. Methods A total of 436 colorectal cancer patients and 568 healthy controls were genotyped for three GSTT2 promoter SNPs (-537G>A, -277T>C and -158G>A, using real-time TaqMan assay and direct sequencing. An electrophoretic mobility shift assay (EMSA was performed to determine the effects of polymorphisms on protein binding to the GSTT2 promoter. Results The -537A allele (-537G/A or A/A was significantly associated with colorectal cancer risk (OR = 1.373, p = 0.025, while the -158A allele (-158G/A or A/A was involved in protection against colorectal cancer (OR = 0.539, p = 0.032. Haplotype 2 (-537A, -277T, -158G was significantly associated with colorectal cancer risk (OR = 1.386, p = 0.021, while haplotype 4 (-537G, -277C, -158A protected against colorectal cancer (OR = 0.539, p = 0.032. EMSA data revealed lower promoter binding activity in the -537A allele than its -537G counterpart. Conclusion Our results collectively suggest that SNPs and haplotypes of the GSTT2 promoter region are associated with colorectal cancer risk in the Korean population.

Zollinger-Ellison syndrome, acromegaly, and colorectal neoplasia

NARCIS (Netherlands)

Tobi, M; Cats, A; Maliakkal, BJ; Kinzie, JL; Maliakkal, R; Dullaart, RPF; Luk, GD

Zollinger-Ellison syndrome (ZES) and acromegaly are two hypersecretory states in which colorectal neoplasia has been described, but the incidence in the former condition may not be increased. We describe four patients with colorectal neoplasia associated with the ZES and review other published

EPIDEMIOLOGICAL EVALUATION OF COLORECTAL CANCER

OpenAIRE

B. Shafayan M. Keyhani

2003-01-01

This study was carried out to analyze certain epidemiological variations in Iranian patients with colorectal cancer. (CRC): From March 1981 up to March 1993, 103 patients were analyzed retrospectively for age, gender, marital state, job, nutritional habits, presenting symptoms and histopathological features. Most of the patients with colorectal cancer were male, age range 20-75 (mean 56), 25.4 percent were long-term smokers and bleeding was the most common symptom. The rectum was the most com...

correlação da variável qualidade de vida

Directory of Open Access Journals (Sweden)

Keika Inouye

2008-01-01

Full Text Available El objetivo del presente estudio fue describir el perfil de una muestra de octogenarios y cuidadores, y correlacionar su calidad de vida. Para ello fue realizado un estudio cuantitativo-descriptivo con una muestra no probabilística, compuesta por 25 octogenarios (y sus cuidadores, los cuales fueron atendidos por el Programa del Medicamento Excepcional en un municipio de São Paulo, en el período de octubre a noviembre de 2006. Las medidas de calidad de vida fueron obtenidas a través de la Escala de Calid de Vida con Enfermedad Alzheimer. Los datos recolectados fueron digitados en un banco de datos en el Statistical Program for Social Sciences for Windows, análizando estadísticas descriptivas y correlacionales de Spearman. El coeficiente "rho" encontrado fue positivo e igual a 0,600, con significancia de 0,01, evidenciando la necesidad de acciones que disminuyan las dificultades enfrentadas por el cuidador como contribuyente indirecto para el fomento de la calidad de vida del octogenario.

Pitfalls and Opportunities in Colorectal Cancer Screening

NARCIS (Netherlands)

P.G. van Putten (Paul)

2013-01-01

textabstractColorectal cancer (CRC) is the third most common cancer and the second leading cause of death from cancer in the Western world. Screening has been shown to reduce CRC incidence and mortality. The first evidence that colorectal cancer screening could effectively reduce mortality dates

Valor educativo y generalización del grupo "Alas por la vida" Educational value and generalization of "Alas por la Vida"

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Alexis Hugo Cantero Ronquillo

2012-03-01

Full Text Available En el tratamiento del cáncer de mama, además de la agresión quirúrgica, en ocasiones mutilante, seguida o precedida por las molestias inherentes a los tratamientos oncoespecíficos, a veces persisten "heridas", que aunque invisibles, no siempre cierran totalmente, y afectan durante mucho tiempo, o toda la vida, a un grupo importante de pacientes y familiares cercanos. El proyecto "Alas por la vida" propone nuevas alternativas en el tratamiento de la mujer con cáncer de mama, que puedan prepararla para una nueva etapa, y vivir con el estatus de enferma crónica, que no refleje invalidez en el desempeño de sus funciones, que alcance la recuperación de su equilibrio biopsicosocial, y, consecuentemente, el disfrute de una adecuada calidad de vida. Mediante intercambios entre sobrevivientes de la enfermedad, familiares y profesionales, charlas científicas, sesiones de preguntas y respuestas, reflexiones de operadas en su lucha contra el cáncer de mama y también de sus esposos, así como con actividades socioculturales, etc., se han logrado resultados muy positivos por este grupo, lo que se refleja en encuestas realizadas a tal efecto. El Grupo de Apoyo a Pacientes Mastectomizadas "Alas por la vida", ha resultado ser un instrumento muy útil para elevar la autoestima y mejorar la calidad de vida de las sobrevivientes, que a la vez ha fortalecido y humanizado nuestra lucha contra el cáncer de mama, y se han aglutinando crecientemente más seguidores en esta noble causa, por lo que recomendamos se organicen proyectos similares en todas las provincias del país.In the treatment of beast cancer besides the surgical aggression occasionally mutilating followed or precedes by the molecules inherent to specific oncologic treatments, sometimes the "wounds" persist that although invisibles, not always are totally closed involving for much time or for life to a significant group of patients and close relatives.The project "Alas por la Vida" proposes

Carcinoma epidermoide del margen anal contra calidad de vida

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Miguel A Reyes Argudín

Full Text Available La calidad de vida de los pacientes debe tenerse en cuenta. Esta representa el resultado final de la actuación médica desde la perspectiva del paciente. En ocasiones solo nos basamos en este criterio para tomar decisiones terapéuticas ante determinadas enfermedades, como el carcinoma epidermoide de margen anal en estadío terminal. El tratamiento y conducta con fines paliativos tiene como objetivo mejorar la calidad de vida de estas personas. Presentamos el caso de paciente varón de 48 años de edad que acude a consulta por presentar lesión en el ano que no le permitía sentarse y después de realizársele todo el estudio necesario para determinar su diagnóstico definitivo (carcinoma epidermoide de ano evaluarlo y determinar el tratamiento requerido para el grado de la enfermedad, nos percatamos que el tratamiento radical no cambiaba la evolución de su estado y se decide tratamiento paliativo para mejorar la calidad de vida. En ocasiones acuden a consulta pacientes que al culminar su estudio, obtienen el diagnóstico de una enfermedad avanzada y es, a partir de este momento, que nuestro pensamiento médico debe cambiar y encaminar nuestros esfuerzos a mejorar la calidad de vida y no llevarlos a un final tormentoso con el objetivo de revertir la evolución de una enfermedad que no tiene regresión.

Fatores associados com a qualidade de vida de homens idosos

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Darlene Mara dos Santos Tavares

2013-06-01

Full Text Available Inquérito domiciliário, transversal e analítico que objetivou descrever as características sociodemográficas, de saúde e a qualidade de vida de homens idosos e verificar os fatores socioeconômicos e de saúde associados à qualidade de vida. Participaram 804 homens idosos. Os dados foram coletados pelos instrumentos: Older Americans Resources and Services(OARS, World Health Organization Quality of Life - Bref (WHOQOL-BREF e Health Organization Quality of Life Assessment for Older Adults(WHOQOL-OLD. Foram realizados análise descritiva, teste t-Student, correlação de Pearson e regressão linear múltipla (p <0,05. Predominaram idosos com 60├ 70 anos, casados, 4├ 8 anos de estudo e renda de um salário mínimo. Os menores escores de qualidade de vida foram no domínio físico e na faceta autonomia e estiveram associados a ausência de companheira e de escolaridade, baixa renda, maior número de morbidades e incapacidade funcional. A incapacidade funcional foi o que mais influenciou a qualidade de vida, excetuando-se o domínio físico e a faceta intimidade.

SEXUALIDADE E SUAS VICISSITUDES NA ESCOLHA DE VIDA RELIGIOSA CONSAGRADA

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Nilvete Soares Gomes

2015-12-01

Full Text Available ResumoA sexualidade humana, por vezes, se traduziu e se traduz num fenômeno complexo. Se no cenário sociocultural se encontram impasses para uma compreensão eximida de tabus da sexualidade, considera-se desafio maior quando se trata da sexualidade no contexto religioso. Para jovens religiosas, as reais motivações para a escolha de vida consagrada poderão não estar evidentes. Este ensaio teórico propõe explorar elementos que possibilitam compreender como se dá a vivência da sexualidade, suas vicissitudes e os atravessamentos da escolha de vida religiosa consagrada. O estudo discute o conceito de sublimação, conforme teoria psicanalítica freudiana, a fim de subsidiar reflexões para institutos de vida consagrada e comunidade científica acerca das vicissitudes da sexualidade.

La asistencia al final de la vida: la ortotanasia

OpenAIRE

Gamarra, Maria del Pilar

2011-01-01

La muerte es un hecho natural e inevitable, que pone fin a la vida. En un sistema sanitario construido sobre el modelo de la terapia curativa, los profesionales de la salud han sido formados y han desarrollado su actividad como si el proceso de la muerte no existiera.Muchos profesionales no tienen incorporada la actuación en el abordaje del paciente en el final de su vida, cómo comunicar la verdad de la situación irreversible, los tratamientos paliativos y el apoyo emocional al paciente y a s...

Formas de Vida Economica en el Arte Rupestre Levantino

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Francisco JORDÁ CERDÁ

2009-10-01

Full Text Available Parece fuera de toda duda que las pinturas rupestres levantinas, dado su carácter eminentemente narrativo e historicista, son una buena fuente de información para estudiar la vida y costumbres de los pueblos entre los que vivían los artistas que las realizaron. En sus múltiples y variadas escenas nos encontramos con fragmentos de su vida diaria, de sus actividades económicas e incluso podemos atisbar los rasgos de su organización social y de sus ideas religiosas.

Screening of colorectal early cancer by radiology

International Nuclear Information System (INIS)

Matsukawa, M.; Usui, Y.; Kobayashi, S.

1988-01-01

The incidence of colorectal cancer has been gradually increasing in Japan, and if the present rate of increase is maintained it has been estimated that it will become the most common of all malignant neoplasms by the year 2000. It has been proved that colorectal cancer can be completely cured, if it is treated in its early phase. Early cancer of the large bowel is defined as a cancer which is limited to the mucosal membrane or submucosal layer, regardless of lymph node and distant metastases. Detection of early cancer improves the overall curability of colorectal cancer. The greatest number of early cancers of the large bowel are polypoid lesions in their macroscopic form, and depressed lesions are rarely encountered. Accordingly, the first step in the detection of early cancer starts with the screening of polypoid lesion by radiology and endoscopy. This paper is concerned with diagnostic accuracy of radiology in the screening of colorectal cancer with endoscopic correlation

Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions

Science.gov (United States)

Zhang, Sheng; Cai, Sanjun; Ma, Yanlei

2018-01-01

The initiation and progression of colorectal cancer (CRC) involves genetic and epigenetic alterations influenced by dietary and environmental factors. Increasing evidence has linked the intestinal microbiota and colorectal cancer. More recently, Fusobacterium nucleatum (Fn), an opportunistic commensal anaerobe in the oral cavity, has been associated with CRC. Several research teams have reported an overabundance of Fn in human CRC and have elucidated the possible mechanisms by which Fn is involved in colorectal carcinogenesis in vitro and in mouse models. However, the mechanisms by which Fn promotes colorectal carcinogenesis remain unclear. To provide new perspectives for early diagnosis, the identification of high risk populations and treatment for colorectal cancer, this review will summarize the relative research progresses regarding the relationship between Fn and colorectal cancer. PMID:29760804

ECSPECT prospective multicentre registry for single-port laparoscopic colorectal procedures

DEFF Research Database (Denmark)

Weiss, Helmut; Zorron, R; Vestweber, K-H

2017-01-01

BACKGROUND: The international multicentre registry ECSPECT (European Consensus of Single Port Expertise in Colorectal Treatment) was established to evaluate the general feasibility and safety of single-port colorectal surgery with regard to preoperative risk assessment. METHODS: Consecutive...... patients undergoing single-port colorectal surgery were enrolled from 11 European centres between March 2010 and March 2014. Data were analysed to assess patient-, technique- and procedure-dependent parameters. A validated sex-adjusted risk chart was developed for prediction of single-port colorectal...

Impacto de los estilos de vida entre cafetaleros y cañeros en la vejez

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Felipe R. Vázquez Palacios

2010-09-01

Full Text Available Este trabajo correlaciona las prácticas agrícolas del café y la caña de azúcar con los estilos de vida, observando la manera en que estos impactan a las personas en edades avanzadas de la parte central de Veracruz, México. La investigación muestra que si bien el café y la caña generan estilos de vida distintos, no generan diferencias sustantivas en la calidad de vida, pero sí diferente concepción y proyecto de vida especialmente en la vejez.

Calidad de vida y ocupación del tiempo libre en la jubilación

OpenAIRE

Hernández Izquierdo, María

2014-01-01

Hemos realizado una investigación sobre la calidad de vida y la ocupación del tiempo libre en personas cercanas a la jubilación. En el proyecto se han analizado el nivel de calidad de vida, las relaciones existentes entre la calidad de vida y otras variables sociodemográficas y las relaciones existentes entre la calidad de vida y otras variables relacionadas con el proceso de jubilación. A través de los resultados del estudio hemos podido corroborar las hipótesis de las que ...

A importância dos valores de vida e qualidade de vida no trabalho no compromisso afectivo à organização

OpenAIRE

Lourenço, Marta Isabel Fernandes

2014-01-01

O objetivo geral deste estudo é avaliar e compreender qual o efeito que as dimensões da Qualidade de Vida no Trabalho (Características do trabalho; Carreira: Formação, Promoção, Apoio, Reconhecimento e Componente Económica; Condições de trabalho; Relações de trabalho; Equilíbrio Trabalho-Família e Lazer) e os valores de vida (família e trabalho) têm no Compromisso Organizacional Afetivo. Para a realização deste estudo foi aplicado um questionário a 161 trabalhadores de uma e...

An audit of colorectal cancer histopathology reports in a Tertiary ...

African Journals Online (AJOL)

Objective: To audit the completeness of histopathologic reports of Colorectal Cancer for prognostic information in a tertiary care hospital in the light of the minimum reporting standards for colorectal cancer resections recently proposed for use in Nigeria. Material and Methods: Twenty–five histopathology reports of colorectal ...

Association between Obesity, Serum Lipids, and Colorectal Polyps in Old Chinese People

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Wen Yang

2013-01-01

Full Text Available Background. Colorectal cancer mostly arises from the polyps of colon. The aim of our study was to examine the association of body mass index (BMI and serum lipids with the colorectal polyps in old Chinese people. Methods. The risk of developing colorectal polyps was studied in 244 subjects (212 men and 32 women, 74.63 ± 11.63 years old who underwent colonoscopy for the first time from January 2008 to July 2012 at the Navy General Hospital, Beijing, China. According to the results of colonoscopy, all the subjects were divided into 112 normal control, 38 right colorectal polyps, 53 left colorectal polyps, and 41 both right and left colorectal polyps groups. The total plasma cholesterol, plasma triglyceride, plasma creatinine concentration, blood urinary nitrogen, and fasting glucose were determined using a multichannel analyzer. Results. There were significant differences among normal control, right colorectal polyps, left colorectal polyps, and both right and left polyps groups, which were the BMI, total cholesterol, triglycerides, creatinine, and urinary nitrogen. In binary logistic regression analysis, there were two risk factors associated with the occurrence of colorectal polyps, which included BMI and systolic blood pressure. Conclusions. Colorectal polyps were significantly associated with increased BMI, total cholesterol, and triglycerides levels.

Los estudios sobre calidad de vida y la perspectiva de la Psicología Positiva

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Graciela Tonón

2015-09-01

Full Text Available Las investigaciones sobre calidad de vida se desarrollaron a partir de la década del 70, si bien el antecedente del concepto data de los años 30 en Europa. En la actualidad, ha quedado establecido que la propuesta teórica de la calidad de vida alberga, como un paraguas, diferentes campos temáticos -la salud, el bienestar psicológico, el desarrollo económico, la vida social, las políticas públicas, la espiritualidad- comprendiendo dos dimensiones: la subjetiva y la objetiva. De esta manera, para estudiar y comprender la calidad de vida se requiere del aporte de diferentes disciplinas, convirtiéndose de esta manera en un concepto multidimensional. La psicología ha contribuido a la investigación de la calidad de vida con conceptos tales como el de satisfacción vital y well-being subjetivo. La perspectiva de la Psicología Positiva con respecto a los estudios sobre calidad de vida, se conforma como mirada que permite conocer y poner énfasis en los atributos positivos de las personas, para enfrentar los cambios de la vida cotidiana, la crisis y la adversidad. 

Combination Effect of Nimotuzumab with Radiation in Colorectal Cancer Cells

International Nuclear Information System (INIS)

Shin, Hye Kyung; Kim, Mi Sook; Jeong, Jae Hoon

2010-01-01

To investigate the radiosensitizing effect of the selective epidermal growth factor receptor (EGFR) inhibitor nimotuzumab in human colorectal cancer cell lines. Four human colorectal cancer cell lines, HCT-8, LoVo, WiDr, and HCT-116 were treated with nimotuzumab and/or radiation. The effects on cell proliferation, viability, and cell cycle progression were measured by MTT, clonogenic survival assay, flow cytometry, and Western blot. An immunoblot analysis revealed that EGFR phosphorylation was inhibited by nimotuzumab in colorectal cancer cell lines. Under these experimental conditions, pre-treatment with nimotuzumab increased radiosensitivity of colorectal cancer cell lines, except for cell line HCT-116. However, cell proliferation or cell cycle progression was not affected by the addition of nimotuzumab, irrespective of irradiation. Nimotuzumab enhanced the radiosensitivity of colorectal cancer cells in vitro by inhibiting EGFR-mediated cell survival signaling. This study provided a rationale for the clinical application of the selective EGFR inhibitor, nimotuzumab in combination with radiation in colorectal cancer cells.

Efectividad del Programa Educativo “Vida Saludable” en el Cambio de Estilos de Vida de Pacientes con Síndrome Metabólico. Hospital I Cono Sur Essalud - Nuevo Chimbote 2015.

OpenAIRE

Rondán Caballero, Nancy Verónica

2016-01-01

El presente estudio de investigación es cuasi-experimental con objetivo Conocer la efectividad del programa educativo “Vida Saludable” en el Cambio de Estilos de Vida de Pacientes con Síndrome Metabólico. Hospital I Cono Sur Essalud - Nuevo Chimbote 2015.Sustentado en Teoría General de Sistemas de Bertalanffy. Muestra 50 pacientes con Síndrome Metabólico, se aplicó un test, un programa educativo y post-test, concluyendo:  El estilo de vida de los pacientes con síndrome metabólico del Hosp...

LA CAPACIDAD Y EL BIENESTAR SUBJETIVO COMO DIMENSIONES DE ESTUDIO DE LA CALIDAD DE VIDA

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Beatriz Yasuko Arita Watanabe

2005-06-01

Full Text Available La Calidad de vida es trabajada científicamente como un constructo muy amplio que abarca diversos significados pero en lo general apunta a la búsqueda de la explicación de la buena vida, aquella que se disfruta, que satisface al que la vive y que le produce estados de felicidad. De allí que sea la persona, desde su percepción, la que evalúe su propia vida, sus capacidades y, en el propio contexto, desarrolle mecanismos de búsqueda del bienestar personal. El Plan de Naciones Unidas para el Desarrollo (PNUD, al hablar de desarrollo humano utiliza un índice combinado que considera niveles de ingreso y educación así como la esperanza de vida de la población. Son medidas objetivas de capacidad centradas en la búsqueda de mejoría de las condiciones de vida de las personas. En México, sus planteamientos son retomados por la Secretaría de Desarrollo Social (Sedesol en su programa “Oportunidades†haciendo referencia a la capacidad de las personas. Este programa no alcanza a definir indicadores que permitan trabajar el estudio de la apreciación de la vida, respecto a las capacidades percibidas y la evaluación del resultado de vida. El objetivo de la presente investigación va dirigido a integrar el estudio de los indicadores objetivos y subjetivos de la capacidad junto con los indicadores del bienestar subjetivo (satisfacción por la vida y felicidad sentida, para considerar a la capacidad y al bienestar subjetivo como dimensiones de explicación de la calidad de vida. La medición de los niveles de ingreso y educación junto con escalas de capacidad para enfrentar la vida y de bienestar subjetivo es utilizada para correr un análisis factorial exploratorio en una muestra representativa de la población adulta de la Zona Urbana de Culiacán, México. Palabras clave: Calidad

La capacidad y el bienestar subjetivo como dimensiones de estudio de la calidad de vida

Directory of Open Access Journals (Sweden)

Beatriz Yasuko Arita Watanabe

2005-01-01

Full Text Available La Calidad de vida es trabajada científicamente como un constructo muy amplio que abarca diversos significados pero en lo general apunta a la búsqueda de la explicación de la buena vida, aquella que se disfruta, que satisface al que la vive y que le produce estados de felicidad. De allí que sea la persona, desde su percepción, la que evalúe su propia vida, sus capacidades y, en el propio contexto, desarrolle mecanismos de búsqueda del bienestar personal. El Plan de Naciones Unidas para el Desarrollo (PNUD, al hablar de desarrollo humano utiliza un índice combinado que considera niveles de ingreso y educación así como la esperanza de vida de la población. Son medidas objetivas de capacidad centradas en la búsqueda de mejoría de las condiciones de vida de las personas. En México, sus planteamientos son retomados por la Secretaría de Desarrollo Social (Sedesol en su programa “Oportunidades” haciendo referencia a la capacidad de las personas. Este programa no alcanza a definir indicadores que permitan trabajar el estudio de la apreciación de la vida, respecto a las capacidades percibidas y la evaluación del resultado de vida. El objetivo de la presente investigación va dirigido a integrar el estudio de los indicadores objetivos y subjetivos de la capacidad junto con los indicadores del bienestar subjetivo (satisfacción por la vida y felicidad sentida, para considerar a la capacidad y al bienestar subjetivo como dimensiones de explicación de la calidad de vida. La medición de los niveles de ingreso y educación junto con escalas de capacidad para enfrentar la vida y de bienestar subjetivo es utilizada para correr un análisis factorial exploratorio en una muestra representativa de la población adulta de la Zona Urbana de Culiacán, México.

Iatrogenic colorectal Kaposi sarcoma complicating a refractory ...

African Journals Online (AJOL)

Kaposi sarcoma is a mesenchymal tumor associated to a human herpes virus-8. It often occurs in human immunodeficiency virus-positive subjects. Colorectal localization is rare. We report the case of a colorectal Kaposi sarcoma complicating a refractory ulcerative colitis treated with surgery after the failure of ...

Clinical Outcomes of Colorectal Cancer in Kenya

African Journals Online (AJOL)

treatment and follow up were included. Patient ... and recurrence and the associated patient and disease ... The incidence of colorectal cancer (CRC) in the devel- ... therapy, disease stage and curative intent (table 3). ... through genetic and family analyses (4,6). ... Polite BN, Dignam JJ: A colorectal cancer model of health.

The inflammatory microenvironment in colorectal neoplasia.

Science.gov (United States)

McLean, Mairi H; Murray, Graeme I; Stewart, Keith N; Norrie, Gillian; Mayer, Claus; Hold, Georgina L; Thomson, John; Fyfe, Nicky; Hope, Mairi; Mowat, N Ashley G; Drew, Janice E; El-Omar, Emad M

2011-01-07

Colorectal cancer (CRC) is a major cause of mortality and morbidity worldwide. Inflammatory activity within the stroma of invasive colorectal tumours is known to be a key predictor of disease activity with type, density and location of immune cells impacting on patient prognosis. To date, there has been no report of inflammatory phenotype within pre-malignant human colonic adenomas. Assessing the stromal microenvironment and particularly, inflammatory activity within colorectal neoplastic lesions is central to understanding early colorectal carcinogenesis. Inflammatory cell infiltrate was assessed by immunohistochemistry in paired colonic adenoma and adjacent normal colonic mucosa samples, and adenomas exhibiting increasing degrees of epithelial cell dysplasia. Macrophage phenotype was assessed using double stain immunohistochemistry incorporating expression of an intracellular enzyme of function. A targeted array of inflammatory cytokine and receptor genes, validated by RT-PCR, was used to assess inflammatory gene expression. Inflammatory cell infiltrates are a key feature of sporadic adenomatous colonic polyps with increased macrophage, neutrophil and T cell (specifically helper and activated subsets) infiltration in adenomatous colonic polyps, that increases in association with characteristics of high malignant potential, namely, increasing degree of cell dysplasia and adenoma size. Macrophages within adenomas express iNOS, suggestive of a pro-inflammatory phenotype. Several inflammatory cytokine genes (CXCL1, CXCL2, CXCL3, CCL20, IL8, CCL23, CCL19, CCL21, CCL5) are dysregulated in adenomas. This study has provided evidence of increased inflammation within pre-malignant colonic adenomas. This may allow potential mechanistic pathways in the initiation and promotion of early colorectal carcinogenesis to be identified.

The Inflammatory Microenvironment in Colorectal Neoplasia

Science.gov (United States)

McLean, Mairi H.; Murray, Graeme I.; Stewart, Keith N.; Norrie, Gillian; Mayer, Claus; Hold, Georgina L.; Thomson, John; Fyfe, Nicky; Hope, Mairi; Mowat, N. Ashley G.; Drew, Janice E.; El-Omar, Emad M.

2011-01-01

Colorectal cancer (CRC) is a major cause of mortality and morbidity worldwide. Inflammatory activity within the stroma of invasive colorectal tumours is known to be a key predictor of disease activity with type, density and location of immune cells impacting on patient prognosis. To date, there has been no report of inflammatory phenotype within pre-malignant human colonic adenomas. Assessing the stromal microenvironment and particularly, inflammatory activity within colorectal neoplastic lesions is central to understanding early colorectal carcinogenesis. Inflammatory cell infiltrate was assessed by immunohistochemistry in paired colonic adenoma and adjacent normal colonic mucosa samples, and adenomas exhibiting increasing degrees of epithelial cell dysplasia. Macrophage phenotype was assessed using double stain immunohistochemistry incorporating expression of an intracellular enzyme of function. A targeted array of inflammatory cytokine and receptor genes, validated by RT-PCR, was used to assess inflammatory gene expression. Inflammatory cell infiltrates are a key feature of sporadic adenomatous colonic polyps with increased macrophage, neutrophil and T cell (specifically helper and activated subsets) infiltration in adenomatous colonic polyps, that increases in association with characteristics of high malignant potential, namely, increasing degree of cell dysplasia and adenoma size. Macrophages within adenomas express iNOS, suggestive of a pro-inflammatory phenotype. Several inflammatory cytokine genes (CXCL1, CXCL2, CXCL3, CCL20, IL8, CCL23, CCL19, CCL21, CCL5) are dysregulated in adenomas. This study has provided evidence of increased inflammation within pre-malignant colonic adenomas. This may allow potential mechanistic pathways in the initiation and promotion of early colorectal carcinogenesis to be identified. PMID:21249124

The inflammatory microenvironment in colorectal neoplasia.

Directory of Open Access Journals (Sweden)

Mairi H McLean

Full Text Available Colorectal cancer (CRC is a major cause of mortality and morbidity worldwide. Inflammatory activity within the stroma of invasive colorectal tumours is known to be a key predictor of disease activity with type, density and location of immune cells impacting on patient prognosis. To date, there has been no report of inflammatory phenotype within pre-malignant human colonic adenomas. Assessing the stromal microenvironment and particularly, inflammatory activity within colorectal neoplastic lesions is central to understanding early colorectal carcinogenesis. Inflammatory cell infiltrate was assessed by immunohistochemistry in paired colonic adenoma and adjacent normal colonic mucosa samples, and adenomas exhibiting increasing degrees of epithelial cell dysplasia. Macrophage phenotype was assessed using double stain immunohistochemistry incorporating expression of an intracellular enzyme of function. A targeted array of inflammatory cytokine and receptor genes, validated by RT-PCR, was used to assess inflammatory gene expression. Inflammatory cell infiltrates are a key feature of sporadic adenomatous colonic polyps with increased macrophage, neutrophil and T cell (specifically helper and activated subsets infiltration in adenomatous colonic polyps, that increases in association with characteristics of high malignant potential, namely, increasing degree of cell dysplasia and adenoma size. Macrophages within adenomas express iNOS, suggestive of a pro-inflammatory phenotype. Several inflammatory cytokine genes (CXCL1, CXCL2, CXCL3, CCL20, IL8, CCL23, CCL19, CCL21, CCL5 are dysregulated in adenomas. This study has provided evidence of increased inflammation within pre-malignant colonic adenomas. This may allow potential mechanistic pathways in the initiation and promotion of early colorectal carcinogenesis to be identified.

Immune reaction and colorectal cancer: friends or foes?

Science.gov (United States)

Formica, Vincenzo; Cereda, Vittore; Nardecchia, Antonella; Tesauro, Manfredi; Roselli, Mario

2014-09-21

The potential clinical impact of enhancing antitumor immunity is increasingly recognized in oncology therapeutics for solid tumors. Colorectal cancer is one of the most studied neoplasms for the tumor-host immunity relationship. Although immune cell populations involved in such a relationship and their prognostic role in colorectal cancer development have clearly been identified, still no approved therapies based on host immunity intensification have so far been introduced in clinical practice. Moreover, a recognized risk in enhancing immune reaction for colitis-associated colorectal cancer development has limited the emphasis of this approach. The aim of the present review is to discuss immune components involved in the host immune reaction against colorectal cancer and analyze the fine balance between pro-tumoral and anti-tumoral effect of immunity in this model of disease.

Serum YKL-40 in risk assessment for colorectal cancer

DEFF Research Database (Denmark)

Johansen, Julia Sidenius; Christensen, Ib Jarle; Jørgensen, Lars Nannestad

2015-01-01

The aim of the present study was to test the hypothesis that high serum YKL-40 associates with colorectal cancer in subjects at risk of colorectal cancer. We measured serum YKL-40 in a prospective study of 4,496 Danish subjects [2,064 men, 2,432 women, median age 61 years (range, 18-97)] referred.......05-1.40; P = 0.012), whereas this was not the case for those with comorbidity (OR, 0.98; 95% CI, 0.84-1.14; P = 0.80). In conclusion, high serum YKL-40 in subjects suspected of colorectal cancer and without comorbidity associates with colorectal cancer. Determination of serum YKL-40 may be useful...

No higher risk for colorectal cancer in atrophic gastritis-related hypergastrinemia.

Science.gov (United States)

Lahner, Edith; Sbrozzi-Vanni, Andrea; Vannella, Lucy; Corleto, Vito Domenico; Di Giulio, Emilio; Delle Fave, Gianfranco; Annibale, Bruno

2012-09-01

Atrophic gastritis of the corporal mucosa is a frequent cause of hypergastrinemia. Hypergastrinemia is implicated in colorectal cancer development. To assess whether hypergastrinemic atrophic gastritis is associated with a higher risk of neoplastic colorectal lesions. Among 441 hypergastrinemic atrophic gastritis patients, 160 who were aged >40 and underwent colonoscopy for anaemia, diarrhoea or colorectal cancer-screening were retrospectively selected. Each patient was age- and gender-matched with a normogastrinemic control with healthy stomach. Controls had colonoscopy, gastroscopy with biopsies and gastrin assessment. 160 hypergastrinemic atrophic gastritis patients and 160 controls were included. 28 atrophic gastritis patients and 36 controls had neoplastic colorectal lesions (p=0.33). Patients and controls did not differ for frequency of colorectal adenomas (10.6% vs. 13.1%, p=0.60) or cancer (6.9% vs. 9.4%, p=0.54). Hypergastrinemic atrophic gastritis was not associated with a higher probability of developing colorectal cancer (OR 1.03, 95% CI 0.34-3.16). Age >50 years (OR 3.86) but not hypergastrinemia (OR 0.61) was associated with colorectal cancer. Hypergastrinemic atrophic gastritis is not associated with higher risk for colorectal cancer. Atrophic gastritis-related hypergastrinemia is not associated with an increased risk of neoplastic colorectal lesions. Closer surveillance of colonic neoplasia in atrophic gastritis patients seems not appropriate. Copyright © 2012 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Perceptions of Malaysian colorectal cancer patients regarding dietary intake: a qualitative exploration.

Science.gov (United States)

Yusof, Afzaninawati Suria; Isa, Zaleha Md; Shah, Shamsul Azhar

2013-01-01

Changes in dietary practices are known to be associated with changes in the health and disease pattern of a population. This study aimed to qualitatively explore the perception of colorectal cancer patients regarding causes of colorectal cancer and the influence of diet. Twelve respondents from three major ethnicities in Malaysia were selected from the quantitative study on dietary pattern and colorectal cancer carried out earlier in this study. In-depth interviews (IDI), conducted from April until June 2012, were mainly in the Malay language with additional use of English and continued until the saturation point was reached. All interviews were autorecorded so that verbatim transcriptions could be created. Causes of colorectal cancer were categorized into internal and external factors. The majority of respondents agreed that there is an association between Western foods and colorectal cancer. Malaysian traditional diet was not related to colorectal cancer as less preservative agents were used. Malaysian diet preparation consisting of taste of cooking (spicy, salty and sour foods) plus type of cooking (fry, grilled and smoked) were considered causes of colorectal cancer. All respondents changed their dietary pattern to healthy food after being diagnosed with colorectal cancer. Advice from doctors regarding suitable food for colorectal cancer was useful in this regard. Eating outside, use of food flavoring ingredients and preservative agents were considered to be the main factors causing colorectal cancer. All respondents admitted that they changed to a healthy diet after being diagnosed with colorectal cancer.

Distinct Gene Expression Signatures in Lynch Syndrome and Familial Colorectal Cancer Type X

DEFF Research Database (Denmark)

Valentin, Mev; Therkildsen, Christina; Veerla, Srinivas

2013-01-01

Heredity is estimated to cause at least 20% of colorectal cancer. The hereditary nonpolyposis colorectal cancer subset is divided into Lynch syndrome and familial colorectal cancer type X (FCCTX) based on presence of mismatch repair (MMR) gene defects.......Heredity is estimated to cause at least 20% of colorectal cancer. The hereditary nonpolyposis colorectal cancer subset is divided into Lynch syndrome and familial colorectal cancer type X (FCCTX) based on presence of mismatch repair (MMR) gene defects....

Role of physical activity and diet after colorectal cancer diagnosis.

Science.gov (United States)

Van Blarigan, Erin L; Meyerhardt, Jeffrey A

2015-06-01

This review summarizes the evidence regarding physical activity and diet after colorectal cancer diagnosis in relation to quality of life, disease recurrence, and survival. There have been extensive reports on adiposity, inactivity, and certain diets, particularly those high in red and processed meats, and increased risk of colorectal cancer. Only in the past decade have data emerged on how such lifestyle factors are associated with outcomes in colorectal cancer survivors. Prospective observational studies have consistently reported that physical activity after colorectal cancer diagnosis reduces mortality. A meta-analysis estimated that each 15 metabolic equivalent task-hour per week increase in physical activity after colorectal cancer diagnosis was associated with a 38% lower risk of mortality. No randomized controlled trials have been completed to confirm that physical activity lowers risk of mortality among colorectal cancer survivors; however, trials have shown that physical activity, including structured exercise, is safe for colorectal cancer survivors (localized to metastatic stage, during and after treatment) and improves cardiorespiratory fitness and physical function. In addition, prospective observational studies have suggested that a Western dietary pattern, high carbohydrate intake, and consuming sugar-sweetened beverages after diagnosis may increase risk of colorectal cancer recurrence and mortality, but these data are limited to single analyses from one of two US cohorts. Additional data from prospective studies and randomized controlled trials are needed. Nonetheless, on the basis of the available evidence, it is reasonable to counsel colorectal cancer survivors to engage in regular physical activity and limit consumption of refined carbohydrates, red and processed meats, and sugar-sweetened beverages. © 2015 by American Society of Clinical Oncology.

Projeto de vida no discurso de jovens músicos

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Aline Moreira Gonçalves

2012-12-01

Full Text Available Investiga-se o que é a música para jovens músicos de São João Del Rei, cidade da região do Campo das Vertentes, Minas Gerais, que convive cotidianamente com bandas e orquestras bicentenárias e onde o fazer musical é forte referência na vida das pessoas, especialmente na de crianças e adolescentes. Tendo-se como referencial teórico a psicossociologia e suas noções de imaginário social, projeto de vida e grupo como sistema cultural, simbólico e imaginário, foram entrevistados 21 jovens vinculados a corporações musicais da cidade. As entrevistas transcritas passaram por procedimentos derivados da análise arqueológica do discurso. Buscou-se explicitar o papel da atividade musical na construção de projetos de vida dos jovens, isso é , nas modalidades de inserção social desses sujeitos no contexto de sua realidade, suas formas de projetar o futuro e lançar-se em busca de algo a ser realizado.

VIDA COMERCIAL DE PITAHAYA AMARILLA TRATADA CON 1-MCP

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LILIANA SERNA-COCK

Full Text Available 1-metilciclopropeno (1-MCP, un inhibidor del etileno, ha sido utilizado para extender la vida comercial de diferentes frutas. El objetivo de este trabajo fue evaluar el efecto de la aplicación de soluciones acuosas de 10, 100 y 200 gL-1 de 1-MCP, con tiempos de exposición de 1, 5 y 10 minutos, sobre la vida comercial de pitahaya amarilla en estado de madurez 4. Durante 15 días de almacenamiento (25 ± 2°C y 75% de humedad relativa, se evaluaron cambios físicos como la pérdida de peso y la aparición de pardeamiento; y se midieron cambios químicos como sólidos solubles, pH, acidez e índice de madurez. Se presentaron diferencias significativas entre los tratamientos. Los resultados demostraron que aplicaciones de 200 gL-1 de 1-MCP durante 10 minutos prolongó por tres días, la vida comercial de la pitahaya amarilla, y redujo cambios en los sólidos solubles y la acidez

Participation and barriers to colorectal cancer screening in Malaysia.

Science.gov (United States)

Yusoff, Harmy Mohamed; Daud, Norwati; Noor, Norhayati Mohd; Rahim, Amry Abdul

2012-01-01

In Malaysia, colorectal cancer is the most common cancer in males and the third most common in females. Mortality due to colorectal cancer can be effectively reduced with early diagnosis. This study was designed to look into colorectal cancer screening participation and its barriers among average risk individuals in Malaysia. A cross sectional study was conducted from August 2009 till April 2010 involving average risk individuals from 44 primary care clinics in West Malaysia. Each individual was asked whether they have performed any of the colorectal cancer screening methods in the past five years. The barrier questions had three domains: patient factors, test factors and health care provider factors. Descriptive analysis was achieved using Statistical Program for Social Sciences (SPSS) version 12.0. A total of 1,905 average risk individuals responded making a response rate of 93.8%. Only 13 (0.7%) respondents had undergone any of the colorectal cancer screening methods in the past five years. The main patient and test factors for not participating were embarrassment (35.2%) and feeling uncomfortable (30.0%), respectively. There were 11.2% of respondents who never received any advice to do screening. The main reason for them to undergo screening was being advised by health care providers (84.6%). The study showed that participation in colorectal cancer screening in Malaysia is extremely low and multiple factors contribute to this situation. Given the importance of the disease, efforts should be made to increase colorectal cancer screening activities in Malaysia.

Colorectal cancer in Malaysia: Its burden and implications for a multiethnic country.

Science.gov (United States)

Veettil, Sajesh K; Lim, Kean Ghee; Chaiyakunapruk, Nathorn; Ching, Siew Mooi; Abu Hassan, Muhammad Radzi

2017-11-01

This study aims to provide an analytical overview of the changing burden of colorectal cancer and highlight the implementable control measures that can help reduce the future burden of colorectal cancer in Malaysia. We performed a MEDLINE search via OVID with the ​Medical Subject Headings (MeSH) terms "Colorectal Neoplasms"[Mesh] and "Malaysia"[Mesh], and PubMed with the key words "colorectal cancer" and "Malaysia" from 1990 to 2015 for studies reporting any clinical, societal, and economical findings associated with colorectal cancer in Malaysia. Incidence and mortality data were retrieved from population-based cancer registries/databases. In Malaysia, colorectal cancer is the second most common cancer in males and the third most common cancer in females. The economic burden of colorectal cancer is substantial and is likely to increase over time in Malaysia owing to the current trend in colorectal cancer incidence. In Malaysia, most patients with colorectal cancer have been diagnosed at a late stage, with the 5-year relative survival by stage being lower than that in developed Asian countries. Public awareness of the rising incidence of colorectal cancer and the participation rates for colorectal cancer screening are low. The efficiency of different screening approaches must be assessed, and an organized national screening program should be developed in a phased manner. It is essential to maintain a balanced investment in awareness programs targeting general population and primary care providers, focused on increasing the knowledge on symptoms and risk factors of colorectal cancer, awareness on benefits of screening, and promotion of healthy life styles to prevent this important disease. Copyright © 2016. Published by Elsevier Taiwan.

Calidad de vida en adultos mayores del hogar de ancianos del municipio Cruces

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María del Carmen Corugedo Rodríguez

Full Text Available Introducción: el proceso de envejecimiento es un hecho relevante para todos los sistemas de salud en el mundo debido a la transición demográfica. Cuba no está exenta de esta realidad, por lo que la calidad de vida del adulto mayor es un tema de gran importancia. Objetivo: caracterizar la calidad de vida percibida en los adultos mayores del Hogar de Ancianos del municipio Cruces. Métodos: se realizó un estudio observacional descriptivo de corte transversal durante el periodo de febrero de 2012 a febrero de 2013. El universo estuvo constituido por los 28 ancianos que viven en el hogar de ancianos del municipio Cruces. La información se obtuvo con la aplicación de la Escala M.G.H. Se aplicaron técnicas estadísticas. Resultados: de forma general los ancianos perciben baja calidad de vida, independientemente de las variables sociodemográficas (edad, sexo y nivel de escolaridad. La dimensión de resultados más bajos fue la satisfacción por la vida. El 82 % de los adultos mayores perciben una baja calidad de vida en relación con la misma, seguida por la dimensión socioeconómica. Conclusiones: casi todos los ancianos de la investigación perciben una baja calidad de vida, debido al predominio de estados de displacer y pobres vínculos o mala calidad en las relaciones con sus familiares.

Caixa é dívida negativa sob a perspectiva de hedging no Brasil?

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Marcio Telles Portal

2013-01-01

Full Text Available O presente estudo investigou se as companhias brasileiras de capital aberto, entre 1995 e 2008, coordenam as políticas de caixa e dívida para efeitos de hedging contra subinvestimento em condições de restrição financeira. Os resultados indicam a inexistência de um componente de hedging usando, simultaneamente, as políticas de caixa e dívida em companhias restritas. Foi observada para as companhias restritas financeiramente uma sensibilidade positiva do caixa ao fluxo de caixa e sensibilidade negativa da dívida ao fluxo de caixa, independentemente da necessidade de hedging. As companhias irrestritas não apresentaram uma sensibilidade do caixa ao fluxo de caixa significante estatisticamente, mas apresentaram sensibilidade negativa da dívida ao fluxo de caixa, resultados também independentes da necessidade de hedging. As evidências contrariam os resultados encontrados por Acharya, Almeida e Campello (2007 no mercado norte-americano, onde caixa e dívida negativa apresentaram de acordo com a necessidade de hedging diferentes papéis na otimização intertemporal dos investimentos em companhias restritas.

Coffee prevents proximal colorectal adenomas in Japanese men: a prospective cohort study.

Science.gov (United States)

Nakamura, Tomiyo; Ishikawa, Hideki; Mutoh, Michihiro; Wakabayashi, Keiji; Kawano, Atsuko; Sakai, Toshiyuki; Matsuura, Nariaki

2016-09-01

This prospective cohort study aimed to show that coffee prevents the recurrence of colorectal tumors (adenomas, precursors of colorectal cancer, and early-stage colorectal cancers) as well as colorectal cancer. The present study included 307 patients who participated in a clinical study that required endoscopy to remove a colorectal tumor. The amount of coffee consumed by the patients at study inclusion and the frequency of colorectal tumors, as detected by colonoscopy over the subsequent 4 years, were assessed. Coffee consumption was determined using a diet survey that included 3-consecutive-day food records. The risk of colorectal tumor recurrence was significantly lower (odds ratio=0.21; 95% confidence interval, 0.06-0.74) in patients who consumed more than three cups of coffee per day compared with those who consumed no coffee. No correlation was observed between the examined factors, including green tea and black tea intake and the amount of caffeine consumed. In subanalysis divided by the tumor location within the colorectum, the odds ratio of colorectal tumor recurrence in the proximal colon showed a tendency toward reduction as coffee consumption increased; however, increased coffee consumption significantly increased colorectal tumor recurrence in the distal colon. We showed that high coffee consumption reduced the overall occurrence of colorectal tumors, affected by the reduction in the proximal colon.

Pathological and Biological Aspects of Colorectal Cancer Treatment.

NARCIS (Netherlands)

Gosens, M.J.E.M.

2008-01-01

Pathological and biological aspects of colorectal cancer treatment. This thesis describes several pathological and biological aspects of colorectal cancer treatment. Different patient populations were investigated including patients with mobile rectal cancer enrolled in the Dutch TME trial, patients

Laser photocoagulation in the palliation of colorectal malignancies

NARCIS (Netherlands)

Mathus-Vliegen, E. M.; Tytgat, G. N.

1986-01-01

Besides surgical intervention, there are virtually no palliative treatment modalities available for bleeding and/or obstructing colorectal malignancy. The usefulness and safety of laser photocoagulation was prospectively investigated in 63 patients with colorectal cancer. The merits were evaluated

Patients' Awareness Of The Prevention And Treatment Of Colorectal Cancer.

Science.gov (United States)

Dziki, Łukasz; Puła, Anna; Stawiski, Konrad; Mudza, Barbara; Włodarczyk, Marcin; Dziki, Adam

2015-09-01

The aim of the study was to assess patients' awareness of the prevention and treatment of colorectal cancer. Patients diagnosed with colorectal cancer, hospitalised at the Department of General and Colorectal Surgery of the Medical University in Łódź during the period from January 2015 to April 2015, were asked to complete a questionnaire concerning their families' medical case record, factors predisposing them to the development of colorectal cancer, the tests applied in diagnostics, and the treatment process. The questionnaire comprised 42 closed-ended questions with one correct answer. A statistical analysis of all answers was carried out. The study group consisted of 30 men and 20 women aged 27-94 years old. A strong, statistically significant negative correlation between a patient's age and his/her awareness of the prevention and treatment of colorectal cancer was noted (pcancer (p=0.008), and the awareness of the prevention programme. The women's group was characterised by statistically significantly greater awareness of colonoscopy as a screening examination (p=0.004). Patients need more information on colorectal cancer, its risk factors, prevention, the treatment process, and postoperative care. Lack of awareness of the colorectal cancer issue can be one of the major factors contributing to the high incidence of this disease.

Meat-Related Compounds and Colorectal Cancer Risk by Anatomical Subsite

Science.gov (United States)

Miller, Paige E.; Lazarus, Philip; Lesko, Samuel M.; Cross, Amanda J.; Sinha, Rashmi; Laio, Jason; Zhu, Jay; Harper, Gregory; Muscat, Joshua E.; Hartman, Terryl J.

2012-01-01

Since meat may be involved in the etiology of colorectal cancer, associations between meat-related compounds were examined to elucidate underlying mechanisms in a population-based case-control study. Participants (989 cases/1,033 healthy controls) completed a food frequency questionnaire with a meat-specific module. Multivariable logistic regression was used to examine associations between meat variables and colorectal cancer; polytomous logistic regression was used for subsite-specific analyses. The following significant positive associations were observed for meat-related compounds: 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and colorectal, distal colon, and rectal tumors; 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and colorectal and colon cancer tumors; nitrites/nitrates and proximal colon cancer; 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and rectal cancer; and benzo[a]pyrene and rectal cancer (P-trends meat type, cooking method, and doneness preference, positive associations between red processed meat and proximal colon cancer and pan-fried red meat and colorectal cancer were found (P-trends nitrites, and nitrates may be involved in colorectal cancer etiology. Further examination into the unexpected inverse associations between poultry and colorectal cancer is warranted. PMID:23441608

AS "LETRAS" DO ESPÍRITO: S. INÁCIO INTÉRPRETE DA VIDA CRISTÃ

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Ulpiano Várquez

1991-01-01

Full Text Available O argumento e ao mesmo tempo o resumo de minha palestra nesta noite é uma convicção: a vida cristã, a vida dos cristãos, se manifesta e se compreende graças ao testemunho das pessoas que viveram ou tentam viver o cristianismo radicalmente; graças às pessoas cuja vida só é inteligível por Jesus Cristo e, assim, nos mostram como é que de fato Cristo vive em nós; como é que de fato nós vivemos em Cristo.

Percepción de la mujer ejecutiva sobre su trabajo y vida familiar

OpenAIRE

Cárdenas Sánchez, Moraima Victoria; Estela Basaldua, Raúl Alfredo; Noriega de la Melena, Danny; Portales Bernal, William Jesús

2016-01-01

La investigación busca identificar la percepción de la mujer ejecutiva sobre su trabajo, vida familiar y la interacción trabajo-vida familiar, con la finalidad de obtener información que pueda ser útil para las empresas y Estado, y que esta información sea referenciada al momento de elaborar planes relacionados a promover el balance entre el trabajo-vida familiar. Para ello, se realizó una investigación cualitativa, se entrevistó a 28 mujeres ejecutivas de Lima, que tienen pers...

Investigation of the roles of exosomes in colorectal cancer liver metastasis.

Science.gov (United States)

Wang, Xia; Ding, Xiaoling; Nan, Lijuan; Wang, Yiting; Wang, Jing; Yan, Zhiqiang; Zhang, Wei; Sun, Jihong; Zhu, Wei; Ni, Bing; Dong, Suzhen; Yu, Lei

2015-05-01

The leading cause of death among cancer patients is tumor metastasis. Tumor-derived exosomes are emerging as mediators of metastasis. In the present study, we demonstrated that exosomes play a pivotal role in the metastatic progression of colorectal cancer. First, a nude mouse model of colorectal cancer liver metastasis was established and characterized. Then, we demonstrated that exosomes from a highly liver metastatic colorectal cancer cell line (HT-29) could significantly increase the metastatic tumor burden and distribution in the mouse liver of Caco-2 colorectal cancer cells, which ordinarily exhibit poor liver metastatic potential. We further investigated the mechanisms by which HT-29-derived-exosomes influence the liver metastasis of colorectal cancer and found that mice treated with HT-29-derived exosomes had a relatively higher level of CXCR4 in the metastatic microenvironment, indicating that exosomes may promote colorectal cancer metastasis by recruiting CXCR4-expressing stromal cells to develop a permissive metastatic microenvironment. Finally, the migration of Caco-2 cells was significantly increased following treatment with HT-29-derived exosomes in vitro, further supporting a role for exosomes in modulating colorectal tumor-derived liver metastasis. The data from the present study may facilitate further translational medicine research into the prevention and treatment of colorectal cancer liver metastasis.

Infertilidad masculina, estilo de vida y nutrición

OpenAIRE

Velicia Izquierdo, Andrea

2012-01-01

La reproducción es un aspecto de vital importancia en nuestras vidas. Por ello, es importante analizar la posible relación de los estilos de vida actuales, con el aumento de la infertilidad masculina en las últimas décadas. Material y métodos: Se llevó a cabo una búsqueda exhaustiva en las principales bases de datos científicas (Pubmed, Science direct y The Cochrane Library). Se descartaron los estudios que no cumplían los criterios de inclusión, y se procedió a analizar los resultados de ...

Advances in endoscopic ultrasound imaging of colorectal diseases

DEFF Research Database (Denmark)

Cârțână, Elena Tatiana; Gheonea, Dan Ionuț; Săftoiu, Adrian

2016-01-01

in colorectal cancer, the monitoring of disease activity in inflammatory bowel disease based on quantification of bowel wall vascularization, and differentiating between benign and malignant subepithelial tumours. Recent reports suggest that EUS elastography enables highly accurate discrimination of colorectal...

Altered JS-2 expression in colorectal cancers and its clinical pathological relevance.

Science.gov (United States)

Lam, Alfred King-Yin; Gopalan, Vinod; Nassiri, Mohammad Reza; Kasim, Kais; Dissanayake, Jayampathy; Tang, Johnny Chuek-On; Smith, Robert Anthony

2011-10-01

JS-2 is a novel gene located at 5p15.2 and originally detected in primary oesophageal cancer. There is no study on the role of JS-2 in colorectal cancer. The aim of this study is to determine the gene copy number and expression of JS-2 in a large cohort of patients with colorectal tumours and correlate these to the clinicopathological features of the cancer patients. We evaluated the DNA copy number and mRNA expression of JS-2 in 176 colorectal tissues (116 adenocarcinomas, 30 adenomas and 30 non-neoplastic tissues) using real-time polymerase chain reaction. JS-2 expression was also evaluated in two colorectal cancer cell lines and a benign colorectal cell line. JS-2 amplification was noted in 35% of the colorectal adenocarcinomas. Significant differences in relative expression levels for JS-2 mRNA between different colorectal tissues were noted (p = 0.05). Distal colorectal adenocarcinoma had significantly higher copy number than proximal adenocarcinoma (p = 0.005). The relative expression level of JS-2 was different between colonic and rectal adenocarcinoma (p = 0.007). Mucinous adenocarcinoma showed higher JS-2 expression than non-mucinous adenocarcinoma (p = 0.02). Early T-stage cancers appear to have higher JS-2 copy number and lower expression of JS-2 mRNA than later stage cancers (p = 0.001 and 0.03 respectively). Colorectal cancer cell lines showed lower expression of JS-2 than the benign colorectal cell line. JS-2 copy number change and expression were shown for the first time to be altered in the carcinogenesis of colorectal cancer. In addition, genetic alteration of JS-2 was found to be related to location, pathological subtypes and staging of colorectal cancer. Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Estilos de vida en los estudiantes de enfermería

OpenAIRE

Martha Ligia Velandia-Galvis; Jean Carlos Arenas-Parra; Nohora Ortega-Ortega

2015-01-01

Objetivo: determinar las principales conductas que constituyen los estilos de vida de los estudiantes de enfermería de una universidad pública. Materiales y Métodos: estudio cuantitativo, descriptivo y transversal. A una muestra de 120 estudiantes de todos los semestres se aplicó el instrumento Cuestionario de Estilos de Vida Saludable, que busca detectar los hábitos de los estudiantes en ocho dimensiones: actividad física, tiempo de ocio, alimentación, consumo de alcohol, cigarrillo y drogas...

Colorectal carcinogenesis-update and perspectives

DEFF Research Database (Denmark)

Raskov, Hans; Pommergaard, Hans-Christian; Burcharth, Jakob

2014-01-01

Colorectal cancer (CRC) is a very common malignancy in the Western World and despite advances in surgery, chemotherapy and screening, it is still the second leading cause of cancer deaths in this part of the world. Numerous factors are found important in the development of CRC including colonocyte....... To identify early cancers, screening programs have been initiated, and the leading strategy has been the use of faecal occult blood testing followed by colonoscopy in positive cases. Regarding the treatment of colorectal cancer, significant advances have been made in the recent decade. The molecular targets...

Gene expression in colorectal cancer

DEFF Research Database (Denmark)

Birkenkamp-Demtroder, Karin; Christensen, Lise Lotte; Olesen, Sanne Harder

2002-01-01

Understanding molecular alterations in colorectal cancer (CRC) is needed to define new biomarkers and treatment targets. We used oligonucleotide microarrays to monitor gene expression of about 6,800 known genes and 35,000 expressed sequence tags (ESTs) on five pools (four to six samples in each...... pool) of total RNA from left-sided sporadic colorectal carcinomas. We compared normal tissue to carcinoma tissue from Dukes' stages A-D (noninvasive to distant metastasis) and identified 908 known genes and 4,155 ESTs that changed remarkably from normal to tumor tissue. Based on intensive filtering 226...

Leer la vida. Una investigación desde la perspectiva narrativa

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Víctor Amar-Rodríguez

2016-01-01

Full Text Available La idea de leer la vida, leer el mundo, no es nueva. Pertenece al pedagogo brasileño Paulo Freire y ha sido el pretexto para iniciarnos en un recorrido investigativo introduciendo la perspectiva narrativa. Leer la vida, para comprenderla y darla a comprender. Dos consignas que queremos compartir con el lector escritor sin perder del horizonte la presencia y labor de la didáctica de la lengua y la literatura en este recorrido que incluye también las pantallas. Un texto humanizado, repleto de referencias a la pintura, la literatura (narrativa y poesía, al cine, a la filosofía, etc., pues qué es la vida, la lectura o la escritura sin esta conexión de entornos vitales.

PLZF Expression during Colorectal Cancer Development and in Normal Colorectal Mucosa according to Body Size, as Marker of Colorectal Cancer Risk

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Francesco Mariani

2013-01-01

Full Text Available Promyelocytic leukemia zinc finger protein (PLZF is a protein involved in various signaling, growth regulatory, and differentiation pathways, including development/function of some T cells. Here, we aimed at the detection of PLZF during colorectal carcinogenesis, using immunofluorescence, and at the evaluation of the colocalization of PLZF with CD2 and CD56 positive cells (T, γδ, NK, and NKT cells, using confocal-microscopy, along colorectal carcinogenesis, since its earliest stages, that is, dysplastic aberrant crypt foci (ACF. Furthermore, we analyzed PLZF in the normal colonic mucosa (NM according to anthropometric parameters of the subject. NM exhibited strong CD56 fluorescent staining. This infiltration was lost in both ACF and colorectal carcinoma (CRC, while PLZF presence increased from NM to ACF and CRC. Strong association was found between CD56+ colonic mucosa cell infiltration and body mass index. Interestingly, an increased stromal PLZF-reactivity was present in NM of obese subjects. This study shows that overexpression of PLZF and exclusion of NK cells in dysplastic microenvironment are very early events in the stepwise sequence leading to CRC and that lower levels of CD56+ cells in NM, together with increased levels of PLZF+ cells, can be a reflection of colon cancer risk due to obesity.

Clinical Usefulness of Serum CYFRA 21-1 in Patients with Colorectal Cancer

International Nuclear Information System (INIS)

Lee, Jai Hyuen

2013-01-01

Among diverse tumor markers, pretreatment evaluation and follow-up detection of recurrence in colorectal cancer are generally evaluated by serum carcinoembryonic antigen (CEA) levels. However, there have been some reports about the low accuracy and high false-positive results of CEA in colorectal cancer. We investigated the clinical utilities of CYFRA 21-1 by comparing CEA and cancer antigen 19-9 (CA 19-9) in pretreatment and recurrent colorectal cancer. Using a solid-phase immunoradiometric assay, serum levels of CYFRA 21-1, CEA and CA 19-9 were analyzed in 132 patients with primary colorectal cancer, 124 healthy controls, 104 patients with benign colorectal disease and 19 patients with recurrent colorectal cancer. We determined three different cutoff values to evaluate the sensitivity of diagnostic performance in pretreatment and recurrent colorectal cancer. CYFRA 21-1 (≥ 1.13 ng/ml) had a sensitivity of 47 %, compared with 37 % for CEA (≥ 3.05 ng/ml) and 32.6 % for CA 19-9 (≥ 23.1 ng/ml) in the initial staging of primary colorectal cancer. Using different cutoff values, CYFRA 21-1 showed higher sensitivity for pretreatment colorectal cancer than CEA and CA 19-9 in adenocarcinoma and adenosquamous carcinoma of this study. A mildly significant correlative relationship was noted between Dukes' stages and three tumor markers (p<0.01). The areas under the receiver operating characteristic curves of CYFRA 21-1, CEA and CA 19-9 were 0.81±0.03, 0.74±0.03 and 0.62±0.04, respectively, for discriminating colorectal cancer patients from patients with benign colorectal disease. In addition, CYFRA 21-1 was determined as the most sensitive tumor marker for evaluating recurrent colorectal cancer for all cutoff values. This study showed that CYFRA 21-1 could be a useful and dependable tumor marker for pretreatment and recurrent colorectal cancer. Further prospective studies on its usefulness with respect to the prognosis and utility of combined tumor markers are needed

Clinical Usefulness of Serum CYFRA 21-1 in Patients with Colorectal Cancer

Energy Technology Data Exchange (ETDEWEB)

Lee, Jai Hyuen [Dankook Univ. Medical College, Yongin (Korea, Republic of)

2013-09-15

Among diverse tumor markers, pretreatment evaluation and follow-up detection of recurrence in colorectal cancer are generally evaluated by serum carcinoembryonic antigen (CEA) levels. However, there have been some reports about the low accuracy and high false-positive results of CEA in colorectal cancer. We investigated the clinical utilities of CYFRA 21-1 by comparing CEA and cancer antigen 19-9 (CA 19-9) in pretreatment and recurrent colorectal cancer. Using a solid-phase immunoradiometric assay, serum levels of CYFRA 21-1, CEA and CA 19-9 were analyzed in 132 patients with primary colorectal cancer, 124 healthy controls, 104 patients with benign colorectal disease and 19 patients with recurrent colorectal cancer. We determined three different cutoff values to evaluate the sensitivity of diagnostic performance in pretreatment and recurrent colorectal cancer. CYFRA 21-1 (≥ 1.13 ng/ml) had a sensitivity of 47 %, compared with 37 % for CEA (≥ 3.05 ng/ml) and 32.6 % for CA 19-9 (≥ 23.1 ng/ml) in the initial staging of primary colorectal cancer. Using different cutoff values, CYFRA 21-1 showed higher sensitivity for pretreatment colorectal cancer than CEA and CA 19-9 in adenocarcinoma and adenosquamous carcinoma of this study. A mildly significant correlative relationship was noted between Dukes' stages and three tumor markers (p<0.01). The areas under the receiver operating characteristic curves of CYFRA 21-1, CEA and CA 19-9 were 0.81±0.03, 0.74±0.03 and 0.62±0.04, respectively, for discriminating colorectal cancer patients from patients with benign colorectal disease. In addition, CYFRA 21-1 was determined as the most sensitive tumor marker for evaluating recurrent colorectal cancer for all cutoff values. This study showed that CYFRA 21-1 could be a useful and dependable tumor marker for pretreatment and recurrent colorectal cancer. Further prospective studies on its usefulness with respect to the prognosis and utility of combined tumor markers are

Nutritional status assessment in colorectal cancer patients.

Science.gov (United States)

Lopes, Joana Pedro; de Castro Cardoso Pereira, Paula Manuela; dos Reis Baltazar Vicente, Ana Filipa; Bernardo, Alexandra; de Mesquita, María Fernanda

2013-01-01

The present study intended to evaluate the nutritional status of Portuguese colorectal patients and associated it with surgery type as well as quality of life outcomes. Malnutrition can affect up to 85% of cancer patients and specifically 30-60% in colorectal cancer and can significantly influence health outcomes. A sample of 50 colorectal cancer patients was evaluated in what refers to several anthropometric measures, food intake, clinical history, complications rate before and after surgery procedure. The sample was divided between convention and fast-track procedures. Most of the individuals were overweight or obese but had lost weight on the past six months. Despite mild, there were signs of malnutrition in this sample with high losses of fat free mass, weight and also fat mass during the hospitalization period. These results reinforce the importance of malnutrition assessment in colorectal patients as well as consider weight loss on the past months and body composition in order to complement nutritional status evaluation. Copyright © AULA MEDICA EDICIONES 2013. Published by AULA MEDICA. All rights reserved.

Radiological and clinical evaluation of colorectal cancer

International Nuclear Information System (INIS)

Shin, O. J.; Chin, S. Y.; Lee, K. S.; Park, S. S.

1982-01-01

One hundred thirty two cases of the pathologically proven colorectal cancer at Korea Atomic Energy Research Institute Hospital in the period from January 1973 to June 1980 were analyzed radiologically and clinically. The results were as follows: 1. The colorectal cancer was prevalent in rectosigmoid area and in the fourth to seventh decade of life. 2. The clinical pictures were classified into two groups. The one was rectosigmoid cancer with bowel habit changes. The other was one with no specific symptoms or signs. The clinical pictures of the right colon cancer were rather indirected, chronic and systemic than those of the left one. 3. The roentgenological findings were classified into two groups. The one was rectum and left colon cancer with symmetrical annular narrowing and the other showed trumpet-like proximal dilatation. 4. The most frequent complication was intestinal obstruction. 5. The majority of colorectal cancer was adenocarcinoma. The squamous cell carcinoma and atypical cell carcinoma were most prevalent in rectum, but malignantly lymphoma often occurred in right colon. The rarest colorectal cancer was atypical cell carcinoma in rectum

La magia de Plaza Sésamo IV

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Revista Chasqui

2015-01-01

Full Text Available Con el apoyo de UNICEF y de TELEVISA- México, se ha conformado un equipo, "Taller de televisión para niños" para diseñar la IV Etapa de Plaza Sésamo, serie de televisión educativa para niños de 3 a 6 años de la América Latina. Este programa ha sido diseñado y producido para estimular el desarrollo de destrezas fundamentales de los pequeños televidentes, preparándoles así para un buen desarrollo en la escuela y proveerlos de actitudes sanas y productivas para su vida futura.

MÁS AÑOS A LA VIDA, ¿MÁS VIDA A LOS AÑOS?

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Alfredo Jácome Roca

2015-03-01

Full Text Available Todos sabemos que los indicadores de salud mejoran con programas sanitarios y educativos como la vacunación, reducción de violencia y accidentes, promoción de la salud mental, reducción de la mortalidad materna, descontaminación ambiental, suministro de agua potable y –a nivel individual– nutrición balanceada (¿dieta mediterránea?, ejercicio físico, manejo del estrés y apartarse de las toxicomanías. Estos factores inciden en la prolongación del ciclo vital en algo más de dos terceras partes de los casos. Los demás factores son de origen genético, asunto de sirtuínas, longitud de los telómeros, radicales libres, o la curiosidad –intensamente estudiada– de poblaciones particularmente longevas en ciertos sitios del planeta. Nos hallamos ante una población que está envejeciendo. Hay menos jóvenes y más ancianos, particularmente en las naciones desarrolladas, por los adelantos de la medicina y el control de la natalidad, esta última de forma voluntaria y libre, o a la fuerza (como con la política china del hijo único. Longevidad significa también gente más sana, menos discapacitada, más productiva. Una reciente publicación en la revista Lancet sobre 240 causas de muerte en 188 países, muestra que la esperanza mundial de vida aumentó de 65.3 años en 1990 a 71.5 años en 2013 (1. Si las tendencias actuales continúan, la esperanza de vida en 2030 será de 85.3 años para las mujeres y de 78.1 años para los hombres, según los investigadores del Instituto de Mediciones y Evaluación de la Salud de la Universidad de Washington, en Seattle. Por supuesto que las cifras varían según el género, la edad, la geografía, o en la medida en que los programas de salud sean mejores. Por ejemplo, los declives en las tasas de mortalidad fueron mayores para las mujeres que para los hombres hasta los 80 años. Las diferencias por género en las tasas de muerte para los adultos de 20 a 44 años se amplían debido al VIH

Qualidade de vida em agricultores orgânicos familiares no interior Paraibano

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Yldry Souza Ramos Queiroz Pessoa

Full Text Available Percebe-se que o padrão produtivo na agricultura de um país determina mudanças significativas na saúde social e ambiental, refletindo-se na qualidade de vida dos agricultores. Objetivou-se caracterizar o processo de trabalho da Agricultura Orgânica Familiar (AOF e sua relação com a qualidade de vida dos trabalhadores. A população pesquisada foi composta de 29 agricultores, com idade média de 50 anos, e a composição familiar se constituiu, em média, de 5 a 8 moradores por domicílio. O tempo médio de trabalho na agricultura é de 39 anos e na agricultura familiar orgânica é de 16 anos. Quanto à renda mensal, verificou-se que a maioria dos trabalhadores pesquisados ganha um valor muito abaixo da média de renda desses trabalhadores. Todos contavam com abastecimento de energia elétrica e de água. No total de 8 propriedades, em 5 não existia coleta de lixo sendo este queimado. Referiram-se ao aparecimento de alguns sintomas como câimbras e fadigas nas pernas. Em relação à qualidade de vida, o domínio psicológico contribuiu positivamente para a qualidade de vida com média e desvio (17,83±12,78 e o domínio ambiente contribuiu negativamente para a qualidade de vida desse grupo (9,00±6,82. Concluiu-se que os trabalhadores têm percepção positiva acerca de sua qualidade de vida e há presença significativa do trabalho coletivo no curso da ação. Os agricultores apresentam dificuldades definidas com problemas de baixa renda devido à pouca venda da produção.

DERECHO A LA VIDA DIGNA EL CONCEPTO JURÍDICO DEL DOLOR DESDE EL DERECHO CONSTITUCIONAL

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Gustavo Adolfo García Arango

2007-11-01

Full Text Available El concepto jurídico del dolor desde el derecho constitucional ha sido abarcado en una sola perspectiva: el reconocimiento del derecho fundamental a la vida, en condiciones dignas. El derecho a la vida se ve afectado por conexidad:cuando el dolor no permite lleva una vida equilibrada en todos sus aspectos, permite la protección constitucional a la vida. Se entiende que el cuerpo es el elemento central en una teoría sobre la vida digna; un cuerpo sufriente, enfermo es un cuerpo limitado y condicionado a muchas variables, incluso sicológicas. El derecho a la salud, el dolor y el derecho fundamental a la vida se encuentran; n tanto que las intervenciones quirúrgicas, el suministro de medicamentos, los tratamientos de todo tipo para paliar el dolor o cortarlo de raíz son la fuente de la cual se ha servido el Tribunal Constitucional Colombiano para tocar el tema del dolor, que también ha abarcado desde la violencia intrafamiliar, el castigo a los menores, el manejo del dolor por parte de los medios de comunicación, la eutanasia y la distanasia.

Genetic prognostic markers in colorectal cancer.

OpenAIRE

Houlston, R S; Tomlinson, I P

1997-01-01

The contribution of molecular genetics to colorectal cancer has been restricted largely to relatively rare inherited tumours and to the detection of germline mutations predisposing to these cancers. However, much is now also known about somatic events leading to colorectal cancer. A number of studies has been undertaken examining possible relations between genetic features and prognostic indices. While many of these studies are small and inconclusive, it is clear that a number of different pa...

Calidad de vida y entorno escolar del niño con epilepsia

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Yanquiel Barrios-Hernández

2013-01-01

Full Text Available El concepto de calidad de vida es un término que designa un tema de gran interés y trascendencia para el ser humano actual y futuro. El hecho de padecer una enfermedad crónica no transmisible como la epilepsia, de una forma u otra interviene en la calidad de vida de las personas. El presente artículo tiene como objetivo explicar la influencia que ejerce la enfermedad sobre la calidad de vida cuando es padecida por infantes de edad escolar. Además se pretende demostrar cómo inciden los factores familiar y escolar en la calidad de vida de la población infante con epilepsia. Las personas profesionales de la enseñanza juegan un rol esencial en este afán de que el infante no sea degradado por el medio en el que se desenvuelve, la explicación de esta afirmación resulta otra de las aspiraciones que se tiene con este artículo.

Evaluation the role of nutritional and individual factors in colorectal cancer

OpenAIRE

Kamran Moshfeghi; Abolfazl Mohammad-Beigi; Davood Hamedi-Sanani; Masoud Bahrami

2011-01-01

Background: Colorectal cancer is one of the most common cancers worldwide including 38% of gastrointestinal cancers. Colorectal cancer is the third type of Iranian men and fourth in women in ranking. The purpose of this study was to determine the role of environmental risk factors in colorectal cancer.Materials and Method: In this case-control study, the authors selected cases from colorectal cancer patients in Arak and controls were selected from Arak hospitals in proportion to the number of...

Optimization of peri-operative care in colorectal surgery

NARCIS (Netherlands)

Kornmann, V.N.N.

2016-01-01

Colorectal cancer is an important health issue, and colorectal surgery is increasingly being performed. During the last years, quality and safety of care, new surgical techniques and attention for peri-operative risks resulted in reduction of postoperative morbidity and mortality. Despite these

Human FK506 binding protein 65 is associated with colorectal cancer

DEFF Research Database (Denmark)

Olesen, Sanne Harder; Christensen, Lise Lotte; Sørensen, Flemming Brandt

2005-01-01

We initiated the present study to identify new genes associated with colorectal cancer. In a previously published microarray study an EST (W80763), later identified as the gene hFKBP10 (NM_021939), was found to be strongly expressed in tumors while absent in the normal mucosa. Here we describe...... this gene hFKBP10 together with its encoded protein hFKBP65 as a novel marker associated with colorectal cancer. Analysis of 31 colorectal adenocarcinomas and 14 normal colorectal mucosa by RealTime PCR for hFKBP10 showed a significant up-regulation in tumors, when compared with normal mucosa....... Immunohistochemical analysis of 26 adenocarcinomas and matching normal mucosa, as well as benign hyperplastic polyps and adenomas, using a monoclonal anti-hFKBP65 antibody, showed that the protein was not present in normal colorectal epithelial cells, but strongly expressed in the tumor cells of colorectal cancer...

The risk of colorectal cancer in patients with type 2 diabetes

DEFF Research Database (Denmark)

Peeters, Paul J H L; Bazelier, Marloes T; Leufkens, Hubert G M

2015-01-01

, 2,759 cases of colorectal cancer were observed among the diabetic study population. Type 2 diabetes was associated with a 1.3-fold increased risk of colorectal cancer (HR 1.26 [95% CI 1.18-1.33]). Among diabetic patients, no association was found with treatment stages. A trend of increased......OBJECTIVE: To assess the risk of colorectal cancer associated with type 2 diabetes, as compared with a nondiabetic reference population, and to study additional associations between treatment stage and duration of obesity and colorectal cancer risk. RESEARCH DESIGN AND METHODS: We conducted...... hazards models were used to derive adjusted hazard ratios (HRs) for colorectal cancer associated with type 2 diabetes. Within the diabetic cohort, associations of colorectal cancer with treatment stages and duration of obesity (BMI ≥30 kg/m(2)) were studied. RESULTS: After a median follow-up of 4.5 years...

Underpinning the repurposing of anthracyclines towards colorectal cancer

DEFF Research Database (Denmark)

Nygård, Sune Boris; Christensen, Ib Jarle; Smith, David Hersi

2013-01-01

Abstract Objective. We propose a repurposing strategy where anthracyclines are reintroduced to a subgroup of patients with metastatic colorectal cancer with the highest likelihood of response. In breast cancer, DNA topoisomerase II alpha gene (TOP2A) alterations predict incremental benefit...... of anthracyclines, but this association has not been investigated in colorectal cancer. Frequency analysis of TOP2A gene alterations in colorectal cancer and the association with prognosis are evaluated and the challenges of using a TOP2A/CEN-17 FISH probe combination are addressed. Material and methods. Formalin......-fixed, paraffin-embedded material from 154 stage III colorectal cancer patients included in the RANX05 clinical trial was retrospectively assessed for TOP2A gene alterations using FISH. The TOP2A/CEN-17 ratio as well as the TOP2A gene copy number alone was used to define gene alterations and associations between...

A vida singular de um jovem militante

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Áurea Maria Guimarães

2012-01-01

Full Text Available Esse artigo é fruto de uma pesquisa realizada no período de 2007 a 2010, junto a jovens militantes da cidade de Campinas, com o objetivo de compreender as diferentes maneiras que conduziam esses jovens tanto a reproduzir um modelo de vida quanto a criar outras possibilidades de militância na relação com esse modelo. Entre as histórias orais de vida narradas por jovens que militavam em diferentes grupos ou instituições, escolhi a vida de Biula, representante do movimento estudantil secundarista, procurando evidenciar que a singularidade desta vida, como também e a de outros jovens, estava conectada à problematização que faziam no interior de certas práticas, histórica e culturalmente constituídas, possibilitando a criação de novas formas de subjetivação nas quais se modificava a experiência que tinham deles mesmos na relação com os seus heróis ou modelos de referência. Palavras-chave: história oral – transcriação – heróis – resistência - processos de singularização.   THE SINGULAR LIFE OF A YOUNG MILITANT ABSTRACT   This article is the result of a research carried out from 2007 to 2010 with   young militants in the city of Campinas, aiming to understand the different ways which conducted these youngsters to both reproduce a life model and create other possibilities of militancy in the relationship with this model. Among oral stories narrated by young militants from different groups or institutions, I have chosen the life of Biula, a representative of the secondary students’ movement, trying to show that the singularity of this life and other youngsters’ lives was connected to the problematization they promoted within certain practices, historically and culturally built, thus enabling the creation of new subjectification modes in which the experience they had of themselves in the relationship with their heroes or reference models has changed. Key words: oral history -  transcreation – heroes �

Migrantes por amor? Ciclo de vida, gênero e a decisão de migrar em diferentes fases da vida

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Viviane Assunção

2016-05-01

interlocutoras de uma pesquisa etnográfica realizada entre 2012 e 2013, a idade é um importante fator a ser considerado para ponderar os riscos, vantagens e desvantagens da migração. Além da faixa etária, outros marcadores do curso de vida, como ter filhas/os, o nascimento das/os netas/os e a idade destes indivíduos também são considerados em suas decisões. O artigo também traz as considerações das interlocutoras da pesquisa sobre o amor, que, segundo elas, difere a cada fase da vida. Mais do que o amor por seus companheiros holandeses, elas evidenciam e reificam a idealização do amor materno.

Chinese peoples' perceptions of colorectal cancer screening: a New Zealand perspective.

Science.gov (United States)

Bong, Genevieve; McCool, Judith

2011-03-25

A national cancer screening programme requires a level of perceived acceptability of the procedure among the target population groups to be successful (that is, achieve a high uptake rate). In this study we explored Chinese immigrants' attitudes and perceptions towards colorectal cancer screening. A grounded theory methodology was used explore the determinants of colorectal cancer screening. In depth one-on-one interviews were conducted and subsequently analysed to develop an appreciation of the perspectives on colorectal cancer screening among Chinese people living in New Zealand. Findings indicated a high degree of perceived acceptability for the concept of a national colorectal cancer screening programme. Chinese participants valued health care and preventive health measures were highly prioritised. However, colorectal cancer suffered from the 'poor cousin' syndrome whereby other more highly publicised cancers, such breast cancer, or skin cancer, were perceived to be more relevant and serious, thus marginalising the perceived priority of colorectal cancer screening. Overall, participants paid close attention to their bodies' balance and were proactive in seeking medical advice. Patient practitioner interaction was also found to be influential in the patient's decision to seek screening. The results of the study suggest that the introduction of a colorectal cancer screening programme in New Zealand would benefit from close attention to cultural determinants of screening uptake to provide an equitable service and outcome. Chinese patients who are eligible for participating in the colorectal cancer screening would benefit from access to appropriately detailed and culturally relevant information on the risks, benefit and procedures associated with colorectal cancer screening.

The prevalence of colorectal adenomas in asymptomatic Korean men and women.

Science.gov (United States)

Yang, Moon Hee; Rampal, Sanjay; Sung, Jidong; Choi, Yoon-Ho; Son, Hee Jung; Lee, Jun Haeng; Kim, Young-Ho; Chang, Dong Kyung; Rhee, Poong-Lyul; Rhee, Jong Chul; Guallar, Eliseo; Cho, Juhee

2014-03-01

Colorectal cancer incidence is rapidly rising in many Asian countries, with rates approaching those of Western countries. This study aimed to evaluate the prevalence and trends of colorectal adenomas by age, sex, and risk strata in asymptomatic Koreans. Cross-sectional study of 19,372 consecutive participants aged 20 to 79 years undergoing screening colonoscopy at the Center for Health Promotion of the Samsung Medical Center in Korea from January 2006 to June 2009. Among participants at average risk, those without a history of colorectal polyps or a family history of colorectal cancer, the prevalence of colorectal adenomas and advanced adenomas were 34.5% and 3.1%, respectively, in men and 20.0% and 1.6%, respectively, in women. The prevalence of adenomas increased with age in both men and women, with a more marked increase for advanced adenoma. Participants with a family history of colorectal cancer or with a history of colorectal polyps had significantly higher prevalence of adenomas compared with participants of average risk (36.9% vs. 26.9%; age- and sex-adjusted prevalence ratio = 1.16; 95% confidence interval, 1.09-1.22). The prevalence of adenomas increased annually in both men and women. In this large study of asymptomatic Korean men and women participating in a colonoscopy screening program, the prevalence of colorectal adenomas was comparable and possibly higher than previously reported in Western countries. Cost-effectiveness studies investigating the optimal age for starting colonoscopy screening and etiological studies to identify the reasons for the increasing trend in colorectal adenomas in Koreans are needed. ©2014 AACR.

Primary colorectal lymphoma: spectrum of imaging findings with pathologic correlation

International Nuclear Information System (INIS)

Lee, Hyun Ju; Han, Joon Koo; Kim, Tae Kyoung; Kim, Young Hoon; Kim, Ah Young; Kim, Kyoung Won; Choi, Ja Young; Choi, Byung Ihn

2002-01-01

Primary colorectal lymphoma is a very uncommon disease; therefore, it has received little attention in the radiology literature. Moreover, imaging features of newly described pathologic subtypes have not been reported such as low-grade B-cell lymphoma arising from mucosa-associated lymphoid tissue and peripheral T-cell lymphoma that involves colorectal area. We retrospectively reviewed double-contrast barium enema and CT scans in the patients with primary colorectal lymphoma. In this article the radiologic appearances of primary colorectal lymphoma are categorized into focal lesion and diffuse lesion. Focal lesion includes polypoid mass, circumferential infiltration with smooth mucosal surface, circumferential infiltration with extensive ulceration, cavitary mass, mucosal nodularity, and mucosal fold thickening. Diffuse lesion includes diffuse ulcerative lesion and diffuse nodular lesion. Peripheral T-cell lymphomas that involve the colon manifested as either a diffuse or focal segmental lesion and showed extensive mucosal ulceration. These findings are similar to those of Crohn's disease or tuberculous colitis and are different from those of previously reported colorectal lymphoma. Low-grade B-cell lymphoma arising from mucosa-associated lymphoid tissue manifest as multiple mucosal nodularity. The imaging features of primary colorectal lymphoma are quite variable and overlap with other colonic pathology; however, it is important for radiologists to know the imaging features of primary colorectal lymphoma with their pathologic correlation. (orig.)

Tailored treatment of metastatic colorectal cancer: clinical and pre-clinical developments

NARCIS (Netherlands)

Kuijpers, A.M.J.

2015-01-01

Colorectal cancer is the third leading cause of cancer-related death in males and females in developed countries. Metastases in distant organs, which develop in 50% of colorectal cancer patients, are responsible for the majority of colorectal cancer deaths. Treatment of metastatic disease should

Vitamin D and asthma-life after VIDA?

Science.gov (United States)

Brehm, John M

2014-09-01

The vitamin D hypothesis postulates that lower vitamin D levels are causally associated with increased asthma risk and asthma severity. Multiple epidemiological studies have shown an inverse relationship between circulating vitamin D levels (in the form of 25-hydroxy vitamin D) and asthma severity and control and lung function. However, in the recently published vitamin D and asthma (VIDA) study, vitamin D supplementation failed to show an improvement in asthma control in adults. This article reviews the current epidemiological and trial evidence for vitamin D and asthma and explores some of the possible alternative explanations for previous findings (including "reverse causation" and the importance of studying children and adults). We also address some of the unique challenges of conducting vitamin D trials and potential ways to address them. Finally, I will argue for further clinical trials of vitamin D in asthma, especially in children, using knowledge gained from the VIDA trial.

Calidad de Vida en Pacientes con Tumores Cerebrales: Importancia de las Variables Psicológicas

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Ana Sanz Cortés

2015-01-01

Full Text Available Los síntomas clínicos de ansiedad y depresión, así como el deterioro cognitivo determinan la calida de vida de los pacientes con tumores cerebrales (Liu, Page, Solheim, Fox y Chang, 2009. El objetivo de este estudio es analizar la calidad de vida y su relación con diferentes variables psicológicas en individuos diagnosticados de glioma hace seis meses. La muestra estuvo formada por 28 pacientes (58.6% hombres con una edad media de 54.38 años, el 89.2% de los cuales estaba recibiendo tratamiento oncológico adyuvante. A todos ellos se les aplicó un protocolo de valoración con un instrumento de calidad de vida y una batería neuropsicológica (ansiedad y depresión, orientación, atención, memoria, lenguaje, gnosias y funciones ejecutivas. Los pacientes del estudio presentaron una peor calidad de vida en determinadas dimensiones (física, familiar, funcional y en la percepción global de bienestar. Todas las áreas de la calidad de vida se asocian con variables de estado de ánimo y la presencia de manifestaciones clínicas de depresión explica una deficitaria calidad de vida. Por otra parte, el mejor rendimiento cognitivo de los pacientes con gliomas en procesos de reconocimiento de objetos, memoria y planificación indica una mayor calidad de vida global de dichos pacientes.

Clinical and biological aspects of mucinous colorectal cancer

NARCIS (Netherlands)

Hugen, N.

2016-01-01

In the Netherlands approximately 5% of all people will develop colorectal cancer during his or her life. The rapid development of individualized therapy for cancer patients has led to an increased interest in tumor subtypes. Currently, colorectal cancer patients are treated in the same way

Satisfacción, bienestar y calidad de vida en el trabajo

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FÉLIX REQUENA SANTOS

2000-01-01

Full Text Available Este artículo analiza empíricamente un modelo de relación entre los valores culturales y la posibilidad de consecución de los objetivos materiales que proporciona una sociedad. Se trata de explicar y cuantificar hasta qué punto la percepción de la estructura ocupacional, medida en forma de satisfacción, está relacionada con el bienestar subjetivo y con la calidad de vida en el trabajo. Para realizar este análisis se han construido modelos de regresión y causales para ver la influencia de un conjunto de efectos estructurales y del bienestar físico y social sobre la calidad de vida y el bienestar subjetivo. Los datos se han tomado de la Encuesta de Calidad de Vida en el Trabajo 1999. Los resultados han puesto de manifiesto que los modelos realizados son significativos, lo que confirma que mayores niveles de satisfacción con la estructura ocupacional implican mejores niveles de calidad de vida. Cuando se trata de verlos niveles de bienestar subjetivo, entonces la satisfacción con la estructura es mejor predictor que la posición social que se ocupe en dicha estructura.

Brahmacharya: a vida escolar hinduísta na Índia Antiga.

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Arilson Oliveira

2012-12-01

Full Text Available O brahmacharya trata-se de uma ordem (ashrama que representa miticamente os pés do demiurgo e da sociedade no hinduísmo clássico, constituída por estudantes das camadas superiores, celibatários e castos, entre a faixa etária média de 5 a 25 anos. Nessa fase da vida, a continência e a obediência absoluta são seus pilares. Leva-se uma vida shramana (ascética e faz-se voto de pobreza e castidade, o qual pode se estender até o final de sua vida (para os intelectuais e sacerdotes ou brahmanas, caso decida não se casar; o que era raro de acontecer e socialmente desmotivado. Além disso, vive-se estritamente em uma situação de internato com um casal guru (homem e mulher mestres em sua kula (casa até sua total formação educacional, seja como comerciante, guerreiro ou intelectual. Na análise atual, observamos como esse processo educacional se constituía e quais os seus arcabouços religiosos envolvidos para a sua total coordenação, envolta de tradição, magia e sentido de vida.

Capacidade funcional, morbidades e qualidade de vida de idosos

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Darlene Mara dos Santos Tavares

2012-01-01

Full Text Available La investigación tiene como objetivo describir el perfil demográfico, la capacidad funcional y la morbilidad de los ancianos, y verificar la calidad de vida relacionado con el número de incapacidad funcional y la morbilidad. Estudio transversal analítico llevado a cabo con 2.142 personas mayores. Los datos fueron recolectados en el hogar con un instrumento estructurado. El análisis se realizó distribución de frecuencias, F-test de ANOVA y Bonferroni (p<0,05. La mayoría eran mujeres, años, casado, años de escolaridad y los ingresos de un salario mínimo. Predominaron los adultos mayores discapacidades funcionales relacionadas con la movilidad y morbilidad, los problemas de visión más frecuente y la columna vertebral y la hipertensión. Las puntuaciones más altas de calidad de vida para las relaciones sociales y el funcionamiento de los sentidos y el más bajo para su desarrollo físico y la autonomía. El mayor número de incapacidad funcional y la morbilidad asociadas con bajas puntuaciones en la calidad de vida.

Calidad de vida del cuidador familiar y dependencia del paciente con Alzheimer

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LINA MARÍA VARGAS ESCOBAR

2010-06-01

Full Text Available El objetivo del estudio fue establecer la relación entre la calidad de vida del cuidador familiar y el grado de dependencia del paciente con Alzheimer. Es un estudio descriptivo correlacional, de corte transversal, con abordaje cuantitativo. Participaron 192 cuidadores familiares de pacientes con Alzheimer pertenecientes al programa Cuidado a Cuidadores® de la Facultad de Enfermería de la Universidad Nacional de Colombia, la Fundación Acción Familiar Alzheimer Colombia y la Asociación Colombiana de Alzheimer. Se aplicaron el instrumento "Calidad de vida versión familiar" de Betty Ferrell, quien define la calidad de vida desde las dimensiones física, psicológica, social y espiritual, y el Índice de Barthel (IB, que mide el grado de dependencia funcional del paciente. La calidad de vida general de los cuidadores obtuvo una puntuación media. El bienestar físico y espiritual presentó una tendencia positiva, mientras que el bienestar psicológico y social de este grupo poblacional mostró una tendencia negativa con riesgo de alteración a futuro. El grado de dependencia funcional del paciente con Alzheimer se encontró en dependencia total a severa, con mayor compromiso en actividades de aseo y arreglo personal. En el estudio no se encontró correlación estadística entre la calidad de vida y el grado de dependencia del paciente con Alzheimer.

De desejos e de cidades: a difícil arte cotidiana da vida coletiva

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Eliana Kuster

2009-08-01

Full Text Available Os prazeres e as dificuldades da vida nas cidades são o nosso ponto de partida para esse texto no qual fazemos um passeio por alguns autores que trataram deste tema: o equilíbrio entre o 'desejo de cidade', ou seja, a forte motivação que impele os homens para a vida coletiva, e o 'desejo na cidade', os impulsos individuais que podem dificultar a formação de um conjunto coeso. Passando por Sade, Calvino e Perec, vamos chegar à origem desse embate na polis grega, ali onde o aspecto político da vida coletiva é pela primeira vez trazido à cena. Desde os gregos, portanto, o homem se pergunta: como pode ser possível a vida nas cidades?

Leptin receptor (Ob-R) mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer

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Erkasap, N.; Ozkurt, M. [Department of Physiology, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Erkasap, S.; Yasar, F. [Department of General Surgery, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Uzuner, K. [Department of Physiology, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Ihtiyar, E. [Department of General Surgery, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Uslu, S.; Kara, M. [Department of Biochemistry, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Bolluk, O. [Department of Biostatistics, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey)

2013-03-19

The objective of the present study was to investigate the effect of leptin on the progression of colorectal carcinoma to metastatic disease by analyzing the serum leptin concentration and Ob-R gene expression in colon cancer tissues. Tissue samples were obtained from 31 patients who underwent surgical resection for colon (18 cases) and metastatic colon (13 cases) cancer. Serum leptin concentration was determined by an enzyme-linked immunosorbent assay (ELISA) and Ob-R mRNA expression by real-time polymerase chain reaction (RT-PCR) for both groups. ELISA data were analyzed by the Student t-test and RT-PCR data were analyzed by the Mann-Whitney U-test. RT-PCR results demonstrated that mRNA expression of Ob-R in human metastatic colorectal cancer was higher than in local colorectal cancer tissues. On the other hand, mean serum leptin concentration was significantly higher in local colorectal cancer patients compared to patients with metastatic colorectal cancer. The results of the present study suggest a role for leptin in the progression of colon cancer to metastatic disease without weight loss. In other words, significantly increased Ob-R mRNA expression and decreased serum leptin concentration in patients with metastatic colon cancer indicate that sensitization to leptin activity may be a major indicator of metastasis to the colon tissue and the determination of leptin concentration and leptin gene expression may be used to aid the diagnosis.

Leptin receptor (Ob-R) mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer

International Nuclear Information System (INIS)

Erkasap, N.; Ozkurt, M.; Erkasap, S.; Yasar, F.; Uzuner, K.; Ihtiyar, E.; Uslu, S.; Kara, M.; Bolluk, O.

2013-01-01

The objective of the present study was to investigate the effect of leptin on the progression of colorectal carcinoma to metastatic disease by analyzing the serum leptin concentration and Ob-R gene expression in colon cancer tissues. Tissue samples were obtained from 31 patients who underwent surgical resection for colon (18 cases) and metastatic colon (13 cases) cancer. Serum leptin concentration was determined by an enzyme-linked immunosorbent assay (ELISA) and Ob-R mRNA expression by real-time polymerase chain reaction (RT-PCR) for both groups. ELISA data were analyzed by the Student t-test and RT-PCR data were analyzed by the Mann-Whitney U-test. RT-PCR results demonstrated that mRNA expression of Ob-R in human metastatic colorectal cancer was higher than in local colorectal cancer tissues. On the other hand, mean serum leptin concentration was significantly higher in local colorectal cancer patients compared to patients with metastatic colorectal cancer. The results of the present study suggest a role for leptin in the progression of colon cancer to metastatic disease without weight loss. In other words, significantly increased Ob-R mRNA expression and decreased serum leptin concentration in patients with metastatic colon cancer indicate that sensitization to leptin activity may be a major indicator of metastasis to the colon tissue and the determination of leptin concentration and leptin gene expression may be used to aid the diagnosis

Leptin receptor (Ob-R mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer

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N. Erkasap

Full Text Available The objective of the present study was to investigate the effect of leptin on the progression of colorectal carcinoma to metastatic disease by analyzing the serum leptin concentration and Ob-R gene expression in colon cancer tissues. Tissue samples were obtained from 31 patients who underwent surgical resection for colon (18 cases and metastatic colon (13 cases cancer. Serum leptin concentration was determined by an enzyme-linked immunosorbent assay (ELISA and Ob-R mRNA expression by real-time polymerase chain reaction (RT-PCR for both groups. ELISA data were analyzed by the Student t-test and RT-PCR data were analyzed by the Mann-Whitney U-test. RT-PCR results demonstrated that mRNA expression of Ob-R in human metastatic colorectal cancer was higher than in local colorectal cancer tissues. On the other hand, mean serum leptin concentration was significantly higher in local colorectal cancer patients compared to patients with metastatic colorectal cancer. The results of the present study suggest a role for leptin in the progression of colon cancer to metastatic disease without weight loss. In other words, significantly increased Ob-R mRNA expression and decreased serum leptin concentration in patients with metastatic colon cancer indicate that sensitization to leptin activity may be a major indicator of metastasis to the colon tissue and the determination of leptin concentration and leptin gene expression may be used to aid the diagnosis.

Gravidez na adolescência e construção de um projeto de vida = Adolescent pregnancy and building a life project = Embarazo en la adolescencia y creación de proyectos de vida

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Kudlowiez, Sara

2014-01-01

Full Text Available O objetivo deste trabalho foi compreender os projetos de vida de um grupo de adolescentes grávidas, investigando quais eram esses projetos antes de as jovens engravidarem e quais os seus planos futuros depois de gravidez se confirmar. Participaram da pesquisa, 16 jovens grávidas, entre 13 e 19 anos, que residiam em Curitiba-PR e eram atendidas em ambulatório de pré-natal em maternidade do SUS. Os cuidados éticos foram observados. Foram utilizadas, como instrumento de pesquisa, entrevistas semiestruturadas, com perguntas baseadas em roteiro que contemplou temas sobre a gravidez na adolescência, tais como: a reação das adolescentes e de suas famílias à gravidez, os projetos de vida dessas adolescentes antes de terem engravidado, seus projetos de vida após a constatação da gravidez; entre outros. As entrevistas foram gravadas, transcritas e, posteriormente, submetidas à análise de conteúdo. Percebeu-se que a maioria das futuras mães não planejou a gravidez, nem tinha pensado sobre suas prováveis repercussões. Os projetos de vida anteriores à gravidez mostraram-se ausentes ou vagamente estruturados – “estudar e trabalhar” – enquanto as consequências da nova realidade não eram percebidas com nitidez pelas jovens. Esse fato pode estar relacionado à qualidade precária do ensino público, que não proporciona ferramentas necessárias para que os alunos desenvolvam a capacidade de abstração e o senso crítico, de modo a elaborar estratégias viáveis para alcançar seus objetivos. Paralelamente, essas adolescentes enfrentam dificuldades no interior de suas famílias e comunidades, que geralmente não lhes fornecem elementos e oportunidades para construir projetos de vida inovadores. Conclui-se que condições como o contexto educacional, social e histórico podem ajudar a compreender a falta de projetos de vida mais autênticos e consistentes

ABORDAJE RELACIONAL AL CONCEPTO BIOLÓGICO DE VIDA Y SUS IMPLICACIONES ÉTICAS Y JURÍDICAS

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Francisco Coutinho

2011-11-01

Full Text Available En el contexto sociocultural actual los avances científicos en la biología,especialmente en la Genética, afectan de muchas formas los interesespúblicos y privados. Por ello, se torna necesario explicitar el conceptobiológico de vida, dado que esa explicitación podrá guiar el establecimentode límites éticos de determinadas inversiones de instituciones estatales,privadas y de legisladores que comúnmente recurren al apoyo de la cienciapara fundamentar sus opiniones. Bajo esta perspectiva articulamosargumentos para fundamentar la concepción relacional de la vida encontraposición al abordaje esencialista o de simple listado de atributos. Estees muy utilizado para definir al ser vivo, mas necesariamente es pocoabarcador y esclarecedor. Tal abordaje ha producido un amplio número dedefiniciones para el concepto sobre lo que es la vida, lo que resulta más enconfusiones que en esclarecimientos. Al contrario, la concepción relacionalde vida parte de la definición de que la vida es  adaptación flexible. Taldefinición emerge a partir de investigaciones realizadas sobre la vidaartificial y privilegia una metafísica de procesos al revés de una metafísicade sustancias. Entretanto, aunque el concepto relacional de la vida tengaventaja sobre la mayoria de los demás, tal vez no sea útil para ayudar adefinir mejor los límites y prerrogativas éticas y legales de intervencionesque amenacen vidas individuales, tales como el aborto y la eutanasia y noacarrear prejuicios o estabelecer privilegios de alcances sociales escasos.Concluimos con una apreciación jurídica del concepto relacional de la vida,especialmente la vida humana y su tutela en Brasil, informando lanaturaleza, los límites y la extensión de esa protección.

El imaginario de los adultos mayores sobre la vida después de la muerte

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Felipe R. Vázquez Palacios

2013-10-01

Full Text Available El trabajo analiza el imaginario de los adultos mayores sobre la vida después de la muerte, en una muestra de creyentes mayores de 60 años, todos ellos creyentes católicos, metodistas, adventistas y pentecostales, que viven en la capital del estado de Veracruz, México. La información se llevó a cabo a través de entrevistas a profundidad y prácticas guiadas sobre el tema. La investigación muestra que el imaginario de la vida en el más allá, tiene que ver con acciones y prácticas, con contextos culturales, históricos, económicos, religiosos, costumbres que la sociedad y/o los individuos han acumulado en su vida cotidiana. La pregunta central que esta presente en todo el trabajo es: ¿Qué papel juegan estos imaginarios en la vida terrenal? ¿Cómo dotan de sentido la vida humana cómo la transforman?

Mudanças nas trajetórias de vida e identidades de mulheres na contemporaneidade

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Carolina de Campos Borges

2013-03-01

Full Text Available Este artigo apresenta os resultados de uma pesquisa realizada no Rio de Janeiro e discute mudanças nas trajetórias de vida de mulheres das classes médias nas últimas décadas. Foram entrevistadas sobre seus projetos de vida dez mulheres pertencentes a duas gerações. Todas as entrevistas foram gravadas e transcritas na íntegra. Os textos resultantes das transcrições foram submetidos a uma análise de discurso. O estudo indicou que o aprofundamento do individualismo na vida social contemporânea vem alterando os projetos de vida dos indivíduos. As trajetórias de vida das mulheres são hoje menos padronizadas; trabalho, profissão e independência financeira são temas que têm ganhado relevância nos seus projetos. Nesse contexto, a identidade feminina é cada vez menos influenciada pelos papéis familiares tradicionais.

Association between phytosterol intake and colorectal cancer risk: a case-control study.

Science.gov (United States)

Huang, Jing; Xu, Ming; Fang, Yu-Jing; Lu, Min-Shan; Pan, Zhi-Zhong; Huang, Wu-Qing; Chen, Yu-Ming; Zhang, Cai-Xia

2017-03-01

A study in rodent models showed that phytosterols protected against colon carcinogenesis, probably by inhibiting dysregulated cell cycle progression and inducing cellular apoptosis. However, epidemiological studies on the relationship between phytosterols and colorectal cancer risk are quite limited. The aim of this study was to investigate dietary phytosterol intake in relation to colorectal cancer risk in the Chinese population. A case-control study was conducted from July 2010 to June 2016, recruiting 1802 eligible colorectal cancer cases plus 1813 age (5-year interval) and sex frequency-matched controls. Dietary information was collected by using a validated FFQ. The OR and 95 % CI of colorectal cancer risk were assessed by multivariable logistic regression models. A higher total intake of phytosterols was found to be associated with a 50 % reduction in colorectal cancer risk. After adjusting for various confounders, the OR of the highest quartile intake compared with the lowest quartile intake was 0·50 (95 % CI 0·41, 0·61, P trendphytosterols. An inverse association was also found between the consumption of β-sitosterol, campesterol, campestanol and colorectal cancer risk. However, stigmasterol intake was related to an increased risk of colorectal cancer. No statistically significant association was found between β-sitostanol and colorectal cancer risk. Stratified analysis by sex showed that the positive association of stigmasterol intake with colorectal cancer risk was found only in women. These data indicated that the consumption of total phytosterols, β-sitosterol, campesterol and campestanol is inversely associated with colorectal cancer risk in a Chinese population.

Reconstruyendo el significado de calidad de vida de los cuidadores en el cuidado: una metasíntesis

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Sonia Patricia Carreño Moreno

2015-01-01

Full Text Available Las enfermedades crónicas no transmisibles afectan la calidad de vida de las personas que las padecen y de sus cuidadores familiares. Se ha demostrado que se cambian los estilos de vida, aparece el dolor y las limitaciones, se altera la socialización y surgen sentimientos de pérdida y muerte. Se requiere por esto hacer una revisión sistemática del conocimiento generado para construir teóricamente el concepto de calidad de vida de los cuidadores familiares. Objetivo: Realizar una integración interpretativa a partir de la evidencia científica del fenómeno de calidad de vida de cuidadores de personas con enfermedad crónica. Método: Metasíntesis de 24 artículos publicados de investigaciones científicas del fenómeno de calidad de vida de cuidadores de personas con enfermedad crónica, de bases de datos electrónicas reconocidas en enfermería y salud a partir del método de Sandelowski y Barroso (2006. Resultados: Emergió un planteamiento hipotético denominado Reconstruyendo el significado de calidad de vida de los cuidadores en el cuidado que se sustenta en tres momentos para el significado de calidad de vida: vivir en desasosiego, vivir para la calidad de vida del otro y construir la propia calidad de vida. Conclusiones: La reconceptualización de la calidad de vida de los cuidadores genera en el cuidador una forma diferente de percibir su experiencia, la cual está condicionada por los asuntos morales que están asociados a la labor de ser cuidador y las opciones de desarrollo humano con el significado espiritual emergente. La construcción del significado de calidad de vida para el cuidador se da a través de la experiencia de cuidado, edificándose en el ejercicio de su rol de cuidador, el cual responde a factores estrechamente relacionados con lo moral y evoluciona tomando un significado espiritual.

Tissue Specific Promoters in Colorectal Cancer

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A. R. Rama

2015-01-01

Full Text Available Colorectal carcinoma is the third most prevalent cancer in the world. In the most advanced stages, the use of chemotherapy induces a poor response and is usually accompanied by other tissue damage. Significant progress based on suicide gene therapy has demonstrated that it may potentiate the classical cytotoxic effects in colorectal cancer. The inconvenience still rests with the targeting and the specificity efficiency. The main target of gene therapy is to achieve an effective vehicle to hand over therapeutic genes safely into specific cells. One possibility is the use of tumor-specific promoters overexpressed in cancers. They could induce a specific expression of therapeutic genes in a given tumor, increasing their localized activity. Several promoters have been assayed into direct suicide genes to cancer cells. This review discusses the current status of specific tumor-promoters and their great potential in colorectal carcinoma treatment.

Estimating diabetes and diabetes-free life expectancy in Mexico and seven major cities in Latin America and the Caribbean Estimación de la esperanza de vida con y sin diabetes en México y siete ciudades importantes de América Latina y el Caribe

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Flavia Andrade

2009-07-01

años o más. Se utilizó el método de Sullivan para estimar la esperanza de vida con o sin diabetes. RESULTADOS: La esperanza de vida con diabetes en hombres de 60 años fue mayor en la Ciudad de México (4,5 años y Bridgetown (3,4 años y menor en La Habana (1,3 años. La esperanza de vida sin diabetes en hombres de 60 años fue mayor en Santiago (17,6 años y menor en Bridgetown (14,2 años y Sao Paulo (14,3 años. En mujeres, la esperanza de vida con diabetes fue mayor en Bridgetown (5,4 años, seguida por Ciudad de México y La Habana; pero estas tres ciudades presentaron la menor esperanza de vida sin diabetes. Las mujeres de 60 años de Buenos Aires presentaron la menor esperanza de vida con diabetes (2,5 años y el mayor valor se observó en Santiago, con una esperanza de vida sin diabetes de 20,7 años. CONCLUSIONES: Las personas de mayor edad de América Latina y el Caribe pueden esperar vivir una gran parte de su vida restante con diabetes. Se observaron grandes diferencias entre las ciudades, en particular, la considerable carga de diabetes en Barbados y México y en mujeres. Dado el rápido crecimiento de la población de adultos mayores en estas sociedades, es vital promover la alimentación sana y la práctica de ejercicios físicos como una forma de reducir la carga de diabetes.

Indeterminate Pulmonary Nodules at Colorectal Cancer Staging

DEFF Research Database (Denmark)

Nordholm-Carstensen, Andreas; Wille-Jørgensen, Peer A; Jorgensen, Lars N

2013-01-01

This study aimed to estimate the prevalence of indeterminate pulmonary nodules and specific radiological and clinical characteristics that predict malignancy of these at initial staging chest computed tomography (CT) in patients with colorectal cancer. A considerable number of indeterminate...... pulmonary nodules, which cannot readily be classified as either benign or malignant, are detected at initial staging chest CT in colorectal cancer patients....

Estudios cualitativos en calidad de vida. Teoría y práctica

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Nora Bayo Barroso

2016-06-01

Full Text Available Esta publicación trata de mostrar la importancia del desarrollo de la metodología cualitativa para el estudio de la calidad de vida. Ofrece una reflexión teórica y metodológica de los estudios cualitativos, donde se examina el papel del contexto y la cultura en este tipo de estudios, así como el rol de los investigadores, es pecialmente durante el proceso de incorporación de los más jóvenes a este campo. Presenta diversos proyectos de investigación sobre calidad de vida en los que se han utilizado métodos cualitativos, en diversos ámbitos: geografía, salud, comunidades, juventud, infancia y yoga en la vida laboral. La autora apuesta por la integración de la metodología cuantitativa y cualitativa, mediante el uso de los métodos mixtos, para el estudio de la calidad de vida

Calidad de vida de los cuidadores de personas con enfermedad crónica

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Sonia Patricia Carreño-Moreno

2016-01-01

Full Text Available El alto impacto epidemiológico, social, económico y cultural de las enfermedades crónicas no transmisibles afecta el significado de calidad de vida en las personas que las padecen y en sus cuidadores familiares. Objetivo: describir la forma como se construye el significado de calidad de vida de cuidadores de personas con enfermedad crónica. Método: investigación desarrollada con la propuesta de metasíntesis cualitativa de Sandelowski y Barroso. Resultados: se presentan tres momentos en la trayectoria: 1 se afecta (destrucción celular programada; 2 se trasforma (autocontrol del desarrollo y crecimiento, y 3 se resignifica (condensación; y cuatro factores condicionantes para la construcción del significado de calidad de vida para el cuidador como son el soporte social, la espiritualidad, la habilidad para cuidar y el tiempo. Conclusiones: la calidad de vida se afecta y se reconstruye en virtud del significado que el cuidador tenga de esta.

Judicialização da vida na contemporaneidade

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Camilla Felix Barbosa de Oliveira

Full Text Available Este artigo visa a empreender um estudo sobre o fenômeno da judicialização da vida na contemporaneidade. Por judicialização, compreende-se o movimento de regulação normativa e legal do viver, do qual os sujeitos se apropriam para a resolução dos conflitos, reproduzindo uns com os outros o controle, o julgamento e a punição das condutas. Nesse sentido, objetiva-se analisar os efeitos dos discursos e das práticas jurídicas sobre as subjetividades, ou seja, sobre as formas de os sujeitos se relacionarem, experimentarem e conceberem suas vidas. Para tanto, utilizar-se-á como disparadores leis, políticas e ações relacionadas à alienação parental e ao bullying, evidenciando as lógicas patológicas e judicializantes que as embasam e suas aproximações com o campo psi. Por fim, propõe-se que a Psicologia esteja em permanente reflexão ético-política, a fim de fomentar a construção de práticas psi inovadoras, que rompam os aprisionamentos produzidos pelo movimento de judicialização e que inaugurem desvios a serviço da valorização da vida.

Heterogenous mismatch-repair status in colorectal cancer

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Joost, Patrick; Veurink, Nynke; Holck, Susanne

2014-01-01

BACKGROUND: Immunohistochemical staining for mismatch repair proteins is efficient and widely used to identify mismatch repair defective tumors. The tumors typically show uniform and widespread loss of MMR protein staining. We identified and characterized colorectal cancers with alternative......, heterogenous mismatch repair protein staining in order to delineate expression patterns and underlying mechanisms. METHODS: Heterogenous staining patterns that affected at least one of the mismatch repair proteins MLH1, PMS2, MSH2 and MSH6 were identified in 14 colorectal cancers. Based on alternative....... CONCLUSIONS: Heterogenous mismatch repair status can be demonstrated in colorectal cancer. Though rare, attention to this phenomenon is recommended since it corresponds to differences in mismatch repair status that are relevant for correct classification. VIRTUAL SLIDES: The virtual slide(s) for this article...

Vaccination with apoptosis colorectal cancer cell pulsed autologous ...

African Journals Online (AJOL)

To investigate vaccination with apoptosis colorectal cancer (CRC) cell pulsed autologous dendritic cells (DCs) in advanced CRC, 14 patients with advanced colorectal cancer (CRC) were enrolled and treated with DCs vaccine to assess toxicity, tolerability, immune and clinical responses to the vaccine. No severe toxicity ...

DEK over expression as an independent biomarker for poor prognosis in colorectal cancer

International Nuclear Information System (INIS)

Lin, Lijuan; Piao, Junjie; Gao, Wenbin; Piao, Yingshi; Jin, Guang; Ma, Yue; Li, Jinzi; Lin, Zhenhua

2013-01-01

The DEK protein is related to chromatin reconstruction and gene transcription, and plays an important role in cell apoptosis. High expression levels of the human DEK gene have been correlated with numerous human malignancies. This study explores the roles of DEK in tumor progression and as a prognostic determinant of colorectal cancer. Colorectal cancer specimens from 109 patients with strict follow-up, and colorectal adenomas from 52 patients were selected for analysis of DEK protein by immunohistochemistry. The correlations between DEK over expression and the clinicopathological features of colorectal cancers were evaluated by Chi-square test and Fisher’s exact tests. The survival rates were calculated by the Kaplan-Meier method, and the relationship between prognostic factors and patient survival was also analyzed by the Cox proportional hazard models. DEK protein showed a nuclear immunohistochemical staining pattern in colorectal cancers. The strongly positive rate of DEK protein was 48.62% (53/109) in colorectal cancers, which was significantly higher than that in either adjacent normal colon mucosa (9.17%, 10/109) or colorectal adenomas (13.46%, 7/52). DEK over expression in colorectal cancers was positively correlated with tumor size, grade, lymph node metastasis, serosal invasion, late stage, and disease-free survival- and 5-year survival rates. Further analysis showed that patients with late stage colorectal cancer and high DEK expression had worse survival rates than those with low DEK expression. Moreover, multivariate analysis showed high DEK expression, serosal invasion, and late stage are significant independent risk factors for mortality in colorectal cancer. DEK plays an important role in the progression of colorectal cancers and it is an independent poor prognostic factor of colorectal cancers

Shared liver-like transcriptional characteristics in liver metastases and corresponding primary colorectal tumors.

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Cheng, Jun; Song, Xuekun; Ao, Lu; Chen, Rou; Chi, Meirong; Guo, You; Zhang, Jiahui; Li, Hongdong; Zhao, Wenyuan; Guo, Zheng; Wang, Xianlong

2018-01-01

Background & Aims : Primary tumors of colorectal carcinoma (CRC) with liver metastasis might gain some liver-specific characteristics to adapt the liver micro-environment. This study aims to reveal potential liver-like transcriptional characteristics associated with the liver metastasis in primary colorectal carcinoma. Methods: Among the genes up-regulated in normal liver tissues versus normal colorectal tissues, we identified "liver-specific" genes whose expression levels ranked among the bottom 10% ("unexpressed") of all measured genes in both normal colorectal tissues and primary colorectal tumors without metastasis. These liver-specific genes were investigated for their expressions in both the primary tumors and the corresponding liver metastases of seven primary CRC patients with liver metastasis using microdissected samples. Results: Among the 3958 genes detected to be up-regulated in normal liver tissues versus normal colorectal tissues, we identified 12 liver-specific genes and found two of them, ANGPTL3 and CFHR5 , were unexpressed in microdissected primary colorectal tumors without metastasis but expressed in both microdissected liver metastases and corresponding primary colorectal tumors (Fisher's exact test, P colorectal tumors may express some liver-specific genes which may help the tumor cells adapt the liver micro-environment.

Dietary Patterns and the Risk of Colorectal Cancer.

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Fung, Teresa T; Brown, Lisa S

2013-03-01

Diet and lifestyle play a significant role in the development of colorectal cancer, but the full complexity of the association is not yet understood. Dietary pattern analysis is an important new technique that may help to elucidate the relationship. This review examines the most common techniques for extrapolating dietary patterns and reviews dietary pattern/colorectal cancer studies published between September 2011 and August 2012. The studies reviewed are consistent with prior research but include a more diverse international population. Results from investigations using a priori dietary patterns (i.e., diet quality scores) and a posteriori methods, which identify existing eating patterns (i.e., principal component analysis), continue to support the benefits of a plant-based diet with some dairy as a means to lower the risk of colorectal cancer, whereas a diet high in meats, refined grains, and added sugar appears to increase risk. The association between colorectal cancer and alcohol remains unclear.

Radiolabelled monoclonal antibodies: magic bullets for colorectal carcinoma

International Nuclear Information System (INIS)

Slade, Linda

1997-01-01

Radiolabelled monoclonal antibodies (MoAbs) have been heralded as highly specific detection agents for many types of tumours. However, because of the many problems that have been associated with the use of these agents, their development and successes did not meet expectations. This paper discusses the use of radiolabelled MoAbs in the diagnosis and staging of colorectal cancer, the type of antibodies and radionuclides investigated over the past thirty years, and the advantages and disadvantages of each. An attempt is made to define the role of radioimmunoscintigraphy (RIS) in the investigation and management of patients with colorectal cancer. It appears that this technique can improve tumour detection, especially when used in conjunction with other imaging modalities. High sensitivities and specificities have been found using radio-labelled MoAbs for investigation of colorectal carcinoma. However, the author estimates there are a number of areas that require further research and improvement before naming radiolabelled MoAbs as 'magic bullets' for colorectal cancer. 8 refs., 3 tabs

[Looking for colorectal cancer in the patients iris?].

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Herber, S; Rehbein, M; Tepas, T; Pohl, C; Esser, P

2008-06-01

Iridology is a noninvasive method from the field of complementary medicine that is said to detect diseases by looking for abnormalities of pigmentation and structure in the iris. Colorectal cancer is an ideal opportunity for screening programs because of its long period of development. Our study investigated the applicability of iridology as an alternative screening method for colorectal cancer. Digital color slides were obtained from both eyes of 29 patients with histologically diagnosed colorectal cancer and from 29 age- and gender-matched healthy control subjects. The slides were presented in random order to acknowledged iridologists without knowledge of the number of patients in the two categories. The iridologists correctly detected 51.7% and 53.4%, respectively, of the patients' slides; therefore, the likelihood was statistically no better than chance. Sensitivity was, respectively, 58.6% and 55.2%, and specificity was 44.8% and 51.7%. Iridology had no validity as a diagnostic tool for detecting colorectal cancer in this study.

Evaluación de la calidad de vida

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Velarde-Jurado Elizabeth

2002-01-01

Full Text Available Este trabajo hace una revisión sobre la evolución del concepto de calidad de vida. Este concepto ha venido cobrando importancia ya que la mayor sobrevida de la población ha mejorado a expensas de un mayor número de personas con algún grado de discapacidad, y de personas con enfermedades crónicas que padecen los efectos de su enfermedad y del tratamiento. En 1948 la Organización Mundial de la Salud (OMS definió a la salud como el completo estado de bienestar físico, mental y social, y no sólo la ausencia de enfermedad, con lo cual el término evolucionó, desde una definición conceptual, hasta métodos objetivos, los cuales, mediante cuestionarios o instrumentos generan escalas e índices que permiten medir las dimensiones que conforman el estado de salud. Actualmente, la salud de una persona se evalúa más allá de su capacidad física y se toman en cuenta su contexto social y su salud mental. Las mediciones pueden estar basadas en encuestas directas a los pacientes, con referencia al inicio de la enfermedad, su diagnóstico y a los cambios de síntomas a través del tiempo. Este artículo presenta un inventario de 126 instrumentos utilizados para medir la calidad de vida en diversas poblaciones y enfermedades. Debido a que la calidad de vida se basa en mediciones con una carga variable de subjetividad, se requiere de métodos de evaluación válidos, reproducibles y confiables. El mejor conocimiento de las evaluaciones para medir calidad de vida permitirá incorporar estos instrumentos en la evaluación integral de individuos, en la conducción de ensayos clínicos y en la investigación de servicios de salud.

Immediately modifiable risk factors attributable to colorectal cancer in Malaysia.

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Naing, Cho; Lai, Pei Kuan; Mak, Joon Wah

2017-08-04

This study aimed to estimate potential reductions in case incidence of colorectal cancer attributable to the modifiable risk factors such as alcohol consumption, overweight and physical inactivity amongst the Malaysian population. Gender specific population-attributable fractions (PAFs) for colorectal cancer in Malaysia were estimated for the three selected risk factors (physical inactivity, overweight, and alcohol consumptions). Exposure prevalence were sourced from a large-scale national representative survey. Risk estimates of the relationship between the exposure of interest and colorectal cancer were obtained from published meta-analyses. The overall PAF was then estimated, using the 2013 national cancer incidence data from the Malaysian Cancer Registry. Overall, the mean incidence rate for colorectal cancer in Malaysia from 2008 to 2013 was 21.3 per 100,000 population, with the mean age of 61.6 years (±12.7) and the majority were men (56.6%). Amongst 369 colorectal cancer cases in 2013, 40 cases (20 men, 20 women), 10 cases (9 men, 1 woman) or 20 cases (16 men,4 women) would be prevented, if they had done physical exercises, could reduce their body weight to normal level or avoided alcohol consumption, assuming that these factors are causally related to colorectal cancer. It was estimated that 66 (17.8%;66/369) colorectal cancer cases (42 men, 24 women) who had all these three risk factors for the last 10 years would have been prevented, if they could control these three risk factors through effective preventive measures. Findings suggest that approximately 18% of colorectal cancer cases in Malaysia would be prevented through appropriate preventive measures such as doing regular physical exercises, reducing their body weight to normal level and avoiding alcohol consumption, if these factors are causally related to colorectal cancer. Scaling-up nationwide public health campaigns tailored to increase physical activity, controlling body weight within normal

Immunotherapy and immunoescape in colorectal cancer

Science.gov (United States)

Mazzolini, Guillermo; Murillo, Oihana; Atorrasagasti, Catalina; Dubrot, Juan; Tirapu, Iñigo; Rizzo, Miguel; Arina, Ainhoa; Alfaro, Carlos; Azpilicueta, Arantza; Berasain, Carmen; Perez-Gracia, José L; Gonzalez, Alvaro; Melero, Ignacio

2007-01-01

Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma. PMID:17990348

Colorectal cancer surgery in the very elderly patient: a systematic review of laparoscopic versus open colorectal resection.

Science.gov (United States)

Devoto, Laurence; Celentano, Valerio; Cohen, Richard; Khan, Jim; Chand, Manish

2017-09-01

Colorectal cancer is the second most common cause of death from neoplastic disease in men and third in women of all ages. Globally, life expectancy is increasing, and consequently, an increasing number of operations are being performed on more elderly patients with the trend set to continue. Elderly patients are more likely to have cardiovascular and pulmonary comorbidities that are associated with increased peri-operative risk. They further tend to present with more locally advanced disease, more likely to obstruct or have disseminated disease. The aim of this review was to investigate the feasibility of laparoscopic colorectal resection in very elderly patients, and whether there are benefits over open surgery for colorectal cancer. A systematic literature search was performed on Medline, Pubmed, Embase and Google Scholar. All comparative studies evaluating patients undergoing laparoscopic versus open surgery for colorectal cancer in the patients population over 85 were included. The primary outcomes were 30-day mortality and 30-day overall morbidity. Secondary outcomes were operating time, time to oral diet, number of retrieved lymph nodes, blood loss and 5-year survival. The search provided 1507 citations. Sixty-nine articles were retrieved for full text analysis, and only six retrospective studies met the inclusion criteria. Overall mortality for elective laparoscopic resection was 2.92% and morbidity 23%. No single study showed a significant difference between laparoscopic and open surgery for morbidity or mortality, but pooled data analysis demonstrated reduced morbidity in the laparoscopic group (p = 0.032). Patients undergoing laparoscopic surgery are more likely to have a shorter hospital stay and a shorter time to oral diet. Elective laparoscopic resection for colorectal cancer in the over 85 age group is feasible and safe and offers similar advantages over open surgery to those demonstrated in patients of younger ages.

Qualidade de vida de familiares cuidadores do doente esquizofrênico Calidad de vida de familiares que cuidan de pacientes esquisofrenicos Life quality of family caregivers of schizophrenic patient

Directory of Open Access Journals (Sweden)

Marina Borges Teixeira

2005-04-01

Full Text Available Objetivou-se verificar o conceito de qualidade de vida (QV de familiares cuidadores de pacientes esquizofrênicos e identificar fatores que interferem em sua qualidade de vidas. Para tanto, foi realizada uma pesquisa exploratório-descritiva, transversal, de campo com 52 familiares cuidadores que residiam com o paciente. Concluiu-se que os familiares definiram qualidade de vida como: "ter saúde, poder trabalhar e sustentar a família" (35; "ter saúde"(9; "ter saúde, ter bons hospitais e morar em um bairro melhor"(3; "ter saúde e continuar tratando deles" (2; "ter saúde e casa própria" (2;"ter dinheiro para tratar melhor dele"(1. Entre os fatores que interferiram em suas vidas o "deixar de ir a igreja"; "não sair com amigos"; "deixar de trabalhar " e "não ter mais tempo para si mesmo" foram os que sobressaíram.Se apuntó a verificar el concepto de calidad de vida (CV de familiares que cuidam de pacientes esquisofrenicos y identificar factores que interfieren en su calidad de vida. Así, una investigación exploratorio-descriptiva y transversal fue cumplida con 52 de conserjes familiares que moram con el paciente. Se concluye que los parientes definieron la calidad de vida como: "tener la salud, trabajar y sostener a la familia" (35; "tener la salud (9; "tener la salud, tener buenos hospitales y vivir en un barrio bueno" (3; "tener la salud y continuar cuidan de ellos" (2; "tener salud y casa propia" (2; "tener el dinero para tratar bien de él" (1. Entre los factores que interfirieron en sus vidas "no ir a la iglesia"; "no salir con los amigos"; "no salir para trabajar" y "no tener más tiempo por su cuidado" fueran los más evidentes.It was aimed to verify the concept of life quality (LQ of family caregivers of schizophrenic patient bearers and to identify the factors that interfere in their quality lives. For that an exploratory-descriptive, and traverse research was accomplished with 52 family caregivers that live with the patient. It

Reverse transcriptase inhibitors as potential colorectal microbicides.

Science.gov (United States)

Herrera, Carolina; Cranage, Martin; McGowan, Ian; Anton, Peter; Shattock, Robin J

2009-05-01

We investigated whether reverse transcriptase (RT) inhibitors (RTI) can be combined to inhibit human immunodeficiency virus type 1 (HIV-1) infection of colorectal tissue ex vivo as part of a strategy to develop an effective rectal microbicide. The nucleotide RTI (NRTI) PMPA (tenofovir) and two nonnucleoside RTI (NNRTI), UC-781 and TMC120 (dapivirine), were evaluated. Each compound inhibited the replication of the HIV isolates tested in TZM-bl cells, peripheral blood mononuclear cells, and colorectal explants. Dual combinations of the three compounds, either NRTI-NNRTI or NNRTI-NNRTI combinations, were more active than any of the individual compounds in both cellular and tissue models. Combinations were key to inhibiting infection by NRTI- and NNRTI-resistant isolates in all models tested. Moreover, we found that the replication capacities of HIV-1 isolates in colorectal explants were affected by single point mutations in RT that confer resistance to RTI. These data demonstrate that colorectal explants can be used to screen compounds for potential efficacy as part of a combination microbicide and to determine the mucosal fitness of RTI-resistant isolates. These findings may have important implications for the rational design of effective rectal microbicides.

Gestión documental sonora: el ciclo de vida digital en los archivos sonoros

Directory of Open Access Journals (Sweden)

Perla Olivia Rodríguez Reséndiz

2017-10-01

Full Text Available La preservación de soportes sonoros analógicos (discos, casetes, cintas de carrete abierto, entre otros, se cimienta en etapas y procesos documentales que se llevan a cabo desde que se incorpora el material en el archivo hasta que es consultado. Los procesos documentales pueden ordenarse en etapas documentales que forman el ciclo de vida. Las etapas documentales empleadas en el archivo analógico quedaron en desuso ante el crecimiento de colecciones digitales. Frente a tal situación, resulta relevante revisar los procesos y determinar las etapas a través de las cuales transita un documento digital sonoro durante el ciclo de vida digital. El artículo que se presenta tiene como objetivos identificar y exponer los principales procesos que forman parte del ciclo de vida digital en la preservación digital de archivos sonoros. Para ello, se analiza literatura científica relacionada con los procesos documentales y el ciclo de vida de los archivos sonoros; además, se examinan algunos de los más relevantes y recientes planes de preservación digital de archivos sonoros formulados en bibliotecas y archivos de alcance nacional. Con ello, se exponen conceptos que definen las etapas y los procesos documentales que se llevan a cabo en un archivo analógico y se presentan los modelos de ciclo de vida digital que incluyen materiales sonoros. Como resultado se expone la identificación y descripción de los principales procesos señalados en los modelos de ciclo de vida digital; además, se propone una ordenación de las principales etapas del ciclo de vida en la preservación digital.

Comparison of colorectal and gastric cancer: Survival and prognostic factors

International Nuclear Information System (INIS)

Moghimi-Dehkordi, Bijan; Safaee, Azadeh; Zali, Mohammad R

2009-01-01

Gastric and colorectal cancers are the most common gastrointestinal malignancies in Iran. We aim to compare the survival rates and prognostic factors between these two cancers. We studied 1873 patients with either gastric or colorectal cancer who were registered in one referral cancer registry center in Tehran, Iran. All patients were followed from their time of diagnosis until December 2006 (as failure time). Survival curves were calculated according to the Kaplan-Meier Method and compared by the Log-rank test. Multivariate analysis of prognostic factors was carried out using the Cox proportional hazard model. Of 1873 patients, there were 746 with gastric cancer and 1138 with colorectal cancer. According to the Kaplan-Meier method 1, 3, 5, and 7-year survival rates were 71.2, 37.8, 25.3, and 19.5%, respectively, in gastric cancer patients and 91.1, 73.1, 61, and 54.9%, respectively, in patients with colorectal cancer. Also, univariate analysis showed that age at diagnosis, sex, grade of tumor, and distant metastasis were of prognostic significance in both cancers ( P < 0.0001). However, in multivariate analysis, only distant metastasis in colorectal cancer and age at diagnosis, grade of tumor, and distant metastasis in colorectal cancer were identified as independent prognostic factors influencing survival. According to our findings, survival is significantly related to histological differentiation of tumor and distant metastasis in colorectal cancer patients and only to distant metastasis in gastric cancer patients. (author)

Australian contemporary management of synchronous metastatic colorectal cancer.

Science.gov (United States)

Malouf, Phillip; Gibbs, Peter; Shapiro, Jeremy; Sockler, Jim; Bell, Stephen

2018-01-01

This article outlines the current Australian multidisciplinary treatment of synchronous metastatic colorectal adenocarcinoma and assesses the factors that influence patient outcome. This is a retrospective analysis of the prospective 'Treatment of Recurrent and Advanced Colorectal Cancer' registry, describing the patient treatment pathway and documenting the extent of disease, resection of the colorectal primary and metastases, chemotherapy and biological therapy use. Cox regression models for progression-free and overall survival were constructed with a comprehensive set of clinical variables. Analysis was intentionn-ton-treat, quantifying the effect of treatment intent decided at the multidisciplinary team meeting (MDT). One thousand one hundred and nine patients presented with synchronous metastatic disease between July 2009 and November 2015. Median follow-up was 15.8 months; 4.4% (group 1) had already curative resections of primary and metastases prior to MDT, 22.2% (group 2) were considered curative but were referred to MDT for opinion and/or medical oncology treatment prior to resection and 70.2% were considered palliative at MDT (group 3). Overall, 83% received chemotherapy, 55% had their primary resected and 23% had their metastases resected; 13% of resections were synchronous, 20% were staged with primary resected first and 62% had only the colorectal primary managed surgically. Performance status, metastasis resection (R0 versus R1 versus R2 versus no resection), resection of the colorectal primary and treatment intent determined at MDT were the most significant factors for progression-free and overall survival. This is the largest Australian series of synchronous metastatic colorectal adenocarcinoma and offers insight into the nature and utility of contemporary practice. © 2016 Royal Australasian College of Surgeons.

Qualidade de vida em pacientes com lesão medular Calidad de vida en pacientes con lesión medular Quality of life in patients with spinal cord injury

Directory of Open Access Journals (Sweden)

Inacia Sátiro Xavier de França

2013-03-01

Full Text Available Objetivou-se medir a qualidade de vida de adultos com lesão medular e identificar os domínios que prejudicam a qualidade de vida desses sujeitos. Estudo epidemiológico, realizado no período 2007-2008, em Unidades Básicas de Saúde de Campina Grande/PB. Participaram 47 sujeitos. Utilizou-se questionário contendo variáveis sociodemográficas, etiologia da lesão; instrumento validado para medir qualidade de vida, contendo quatro domínios: Físico, Ambiental, Relações Sociais e Psicológico, com respectivas facetas. Os dados coletados foram processados por meio de análise descritiva e estatística. Domínios com menores escores: Ambiental (55,20 pontos; Físico (58,59 pontos. Facetas que mais comprometem os domínios: locomoção (55,3%, trabalho (55,3%, dinheiro (80,9%, informações (51%, lazer (68,1%; vida sexual (34%. Os resultados expressam a insatisfação dos investigados com a qualidade de vida. O enfermeiro deve contribuir para a reabilitação e reinclusão social da pessoa com lesão medular, respeitando suas limitações, enfatizando o potencial remanescente e a capacidade para autocuidado.Se objetivó medir la calidad de vida de adultos con lesión medular e identificar los dominios que afectan la calidad de vida de estos sujetos. Estudio epidemiológico realizado entre 2007-2008 en Unidades Básicas de Salud, Campina Grande/PB. Participaron 47 sujetos. Se utilizó cuestionario conteniendo variables sociodemográficas, etiología de la lesión; instrumento validado para medir la calidad de vida conteniendo cuatro dominios: Físico, Medio Ambiental, Relaciones Sociales, Psicológicas, con respectivas facetas. Los datos recolectados fueron procesados por medio de análisis descriptivo y estadístico. Los dominios con puntuaciones más bajas: Medio Ambiente (55,20 puntos; Físico (58,59 puntos. Facetas que más comprometen los dominios: locomoción (55,3%, trabajo (55,3%, dinero (80,9%, información (51%, recreación (68

Dietary patterns and the risk of colorectal adenomas: the Black Women's Health Study.

Science.gov (United States)

Makambi, Kepher H; Agurs-Collins, Tanya; Bright-Gbebry, Mireille; Rosenberg, Lynn; Palmer, Julie R; Adams-Campbell, Lucile L

2011-05-01

Colorectal adenomas are benign lesions that may be precursors to colorectal cancer. No studies of African American women have investigated dietary patterns and the risk of developing colorectal adenomas. We examined data from the Black Women's Health Study to determine whether dietary patterns are associated with the risk of developing colorectal adenomas. This is a prospective cohort study of 59,000 participants followed biennially since 1995. During 155,414 person-years of follow-up from 1997 to 2007 among women who had had at least one screening colonoscopy, 620 incident cases of colorectal adenomas were identified. By using Cox regression models, we obtained incidence rate ratios (IRR) for colorectal adenoma in relation to quintiles of each of two dietary patterns, adjusting for other colorectal adenoma risk factors. Two dietary patterns, Western and prudent, were utilized to assess the association between dietary intake and adenoma risk. The highest quintile of prudent diet, relative to the lowest quintile, was significantly associated with 34% lower colorectal adenoma risk overall (IRR = 0.66; 95% CI, 0.50-0.88; P(trend) pattern were associated with a higher risk of developing colorectal adenoma (IRR = 1.42; 95% CI, 1.09-1.85 for the highest quintile relative to the lowest; P(trend) = 0.01). Our findings suggest that African American women may be able to reduce their risk of developing colorectal adenomas by following a prudent dietary pattern and avoiding a more Western pattern. A dietary modification could have a strong impact in colorectal adenoma prevention in African American women. ©2011 AACR.

Colorectal Cancer Screening: A Circle of Health for Alaskans

Science.gov (United States)

... in the colon and rectum is often called colorectal cancer. But in this brochure we use the term ... tests can be used to find polyps or colorectal cancer. Each can be used alone. Sometimes they are ...

Repercusiones de la salud bucal sobre calidad de vida por ciclo vital individual

Directory of Open Access Journals (Sweden)

Iván Porto Puerta

2017-07-01

Full Text Available La calidad de vida re ere ser un tema muy debatido y estudiado, por ser el objetivo nal básico de la salud pública. Diversas investigaciones reportan su relación con el estado de salud personal apareciendo el concepto Calidad de vida relacionada con la Salud (CVRS y a su vez se encuentran relaciones más especí cas que reportan como alteraciones en diferentes sistemas y órganos del cuerpo como la boca, impactan en ella, apareciendo también el concepto de Calidad de vida relacionada con la Salud Bucal (CVRSB. El impacto de la CVRSB ha sido estudiado principalmente en adultos mayores pero solo a través de estos últimos años se ha estudiado en diferentes etapas de la vida y poco se dispone de manera conjunta de la evolución de este concepto a través de las etapas de la vida. Objetivo. Identi car principales afecciones bucales y sus repercusiones sobre la CVRSB por cada etapa del ciclo vital individual (CVI. Metodología. Se realizó una revisión sistemática, a través de buscadores Med-line, Pubmed, Scielo, Scopus, Latin index, Redalyc y Google académico seleccionando artículos de investigación originales, casos clínicos y revisiones realizadas en español, francés e inglés. Resultados. En las primeras etapas de la vida la caries dental corresponde a la enfermedad bucal que más impacta sobre la Calidad de vida, por otro lado las limitaciones funcionales, tales como comer, dormir y hablar son las repercusiones más comprometidas; a partir de la adolescencia hasta el nal de la vida, una inadecuada estética dento-facial representa la afección que más compromete CVRSB generando así, alteraciones psicosociales tales como depresión, ansiedad y aislamiento. Conclusiones. El impacto de las diferentes afecciones bucales sobre la CVRSB cambia a través del CVI por las diferentes percepciones y prioridades propias de cada etapa y prevalencia de las enfermedades bucales. Estos resultados re ejan un gran

Do valor da vida senciente e autoconsciente

Directory of Open Access Journals (Sweden)

Milene Consenso Tonetto

2004-01-01

Full Text Available O objetivo principal deste trabalho é analisar a posição assumida por Peter Singer em relação à questão do valor da vida dos seres humanos e não-humanos. Reconstruo, primeiramente, a argumentação desenvolvida por Singer no artigo Animals and Value of Life no qual questiona se é moralmente correto tirar a vida de animais para fins de nutrição ou experimentação. Analiso, em segundo lugar, diferentes posições, a saber: algumas tradições religiosas; os filósofos clássicos: René Descartes e Jeremy Bentham; os filósofos contemporâneos: Tom Regan e Michael Tooley; as filósofas feministas: Nel Noodings e Carol Gilligan. Finalmente, avalio criticamente o conceito de pessoa utilizado por Singer e sua posição em relação aos animais não-humanos.

Dietary patterns and colorectal adenomas in Lynch syndrome: the GEOLynch cohort study.

Science.gov (United States)

Botma, Akke; Vasen, Hans F A; van Duijnhoven, Fränzel J B; Kleibeuker, Jan H; Nagengast, Fokko M; Kampman, Ellen

2013-02-01

Patients with Lynch syndrome (LS) have a high risk of developing colorectal cancer due to mutations in mismatch repair genes. Because dietary factors, alone and in combination, influence sporadic colorectal carcinogenesis, the association of dietary patterns with colorectal adenomas in LS patients was assessed. In the GEOLynch cohort of 486 persons with LS, dietary information was collected, using a food frequency questionnaire. Dietary pattern scores were obtained by principal components analysis. Hazard ratios (HR) between dietary patterns and colorectal adenomas were calculated using Cox regression models. Robust sandwich variance estimates were used to control for dependency within families. Final models were adjusted for age, sex, smoking habits, colorectal adenoma history, and extent of colon resection. During a median follow-up of 20 months, colorectal adenomas were detected in 58 persons. Four dietary patterns were identified: a "Prudent," "Meat," "Snack," and "Cosmopolitan" pattern. Individuals within the highest tertile of the "Prudent" pattern had a HR of 0.73 (95% confidence interval [CI], 0.32-1.66) for colorectal adenomas, compared with the lowest tertile. Those with high "Meat" pattern scores had a HR of 1.70 (95% CI, 0.83-3.52). A high "Snack" pattern was associated with an increased risk of colorectal adenomas (HR, 2.16; 95% CI, 1.03-4.49). A HR of 1.25 (95% CI, 0.61-2.55) was observed for persons in the highest tertile of the "Cosmopolitan" pattern. These findings suggest that dietary patterns may be associated with development of colorectal adenoma in patients with Lynch syndrome. The directions of these findings are corroborative with those observed in studies investigating sporadic colorectal cancer. Copyright © 2012 American Cancer Society.

EMX2 gene expression predicts liver metastasis and survival in colorectal cancer.

Science.gov (United States)

Aykut, Berk; Ochs, Markus; Radhakrishnan, Praveen; Brill, Adrian; Höcker, Hermine; Schwarz, Sandra; Weissinger, Daniel; Kehm, Roland; Kulu, Yakup; Ulrich, Alexis; Schneider, Martin

2017-08-22

The Empty Spiracles Homeobox (EMX-) 2 gene has been associated with regulation of growth and differentiation in neuronal development. While recent studies provide evidence that EMX2 regulates tumorigenesis of various solid tumors, its role in colorectal cancer remains unknown. We aimed to assess the prognostic significance of EMX2 expression in stage III colorectal adenocarcinoma. Expression levels of EMX2 in human colorectal cancer and adjacent mucosa were assessed by qRT-PCR technology, and results were correlated with clinical and survival data. siRNA-mediated knockdown and adenoviral delivery-mediated overexpression of EMX2 were performed in order to investigate its effects on the migration of colorectal cancer cells in vitro. Compared to corresponding healthy mucosa, colorectal tumor samples had decreased EMX2 expression levels. Furthermore, EMX2 down-regulation in colorectal cancer tissue was associated with distant metastasis (M1) and impaired overall patient survival. In vitro knockdown of EMX2 resulted in increased tumor cell migration. Conversely, overexpression of EMX2 led to an inhibition of tumor cell migration. EMX2 is frequently down-regulated in human colorectal cancer, and down-regulation of EMX2 is a prognostic marker for disease-free and overall survival. EMX2 might thus represent a promising therapeutic target in colorectal cancer.

Colorectal Cancer - What You Need to Know

Centers for Disease Control (CDC) Podcasts

This podcast is based on the July, 2011 CDC Vital Signs report. Colorectal cancer kills about 50,000 men and women every year. Screening can save lives! Screening can find abnormal growths so they can be removed before turning into cancer, and can find the cancer early, when it's easiest to treat. If you're over 50, talk to your doctor about getting screened for colorectal cancer.

Ranitidine as adjuvant treatment in colorectal cancer

DEFF Research Database (Denmark)

Nielsen, Hans Jørgen; Christensen, Ib Jarle; Moesgaard, F

2002-01-01

BACKGROUND: Results from short-term studies of histamine type 2 (H2) receptor antagonists on survival of patients with solid tumours are debatable. In this study the efficacy of the H2-receptor antagonist ranitidine on long-term survival of patients with colorectal cancer was evaluated. METHODS...... curative resection of colorectal cancer and who do not receive perioperative blood transfusion and do not develop postoperative infectious complications....

Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.

Science.gov (United States)

Jiang, Haiming; Deng, Rong; Yang, Xiuyan; Shang, Jialin; Lu, Shaoyong; Zhao, Yanlong; Song, Kun; Liu, Xinyi; Zhang, Qiufen; Chen, Yu; Chinn, Y Eugene; Wu, Geng; Li, Jian; Chen, Guoqiang; Yu, Jianxiu; Zhang, Jian

2017-09-01

The binding of adenomatous polyposis coli (APC) to its receptor Asef relieves the negative intramolecular regulation of Asef and leads to aberrant cell migration in human colorectal cancer. Because of its crucial role in metastatic dissemination, the interaction between APC and Asef is an attractive target for anti-colorectal-cancer therapy. We rationally designed a series of peptidomimetics that act as potent inhibitors of the APC interface. Crystal structures and biochemical and cellular assays showed that the peptidomimetics in the APC pocket inhibited the migration of colorectal cells by disrupting APC-Asef interaction. By using the peptidomimetic inhibitor as a chemical probe, we found that CDC42 was the downstream GTPase involved in APC-stimulated Asef activation in colorectal cancer cells. Our work demonstrates the feasibility of exploiting APC-Asef interaction to regulate the migration of colorectal cancer cells, and provides what to our knowledge is the first class of protein-protein interaction inhibitors available for the development of cancer therapeutics targeting APC-Asef signaling.

Interobserver agreement in the histologic diagnosis of colorectal polyps. the experience of the multicenter adenoma colorectal study (SMAC).

Science.gov (United States)

Costantini, Massimo; Sciallero, Stefania; Giannini, Augusto; Gatteschi, Beatrice; Rinaldi, Paolo; Lanzanova, Giuseppe; Bonelli, Luigina; Casetti, Tino; Bertinelli, Elisabetta; Giuliani, Orietta; Castiglione, Guido; Mantellini, Paola; Naldoni, Carlo; Bruzzi, Paolo

2003-03-01

Current clinical practice guidelines for patients with colorectal polyps are mainly based on the histologic characteristics of their lesions. However, interobserver variability in the assessment of specific polyp characteristics was evaluated in very few studies. The purpose of this study was to evaluate the interobserver agreement of four pathologists in the diagnosis of histologic type of colorectal polyps and in the degree of dysplasia and of infiltrating carcinoma in adenomas. A stratified random sample of 100 polyps was obtained from the 4,889 polyps resected within the Multicentre Adenoma Colorectal Study (SMAC), and the slides were blindly reviewed by the four pathologists. Agreement was analyzed using kappa statistics. A median kappa of 0.89 (range 0.79-1.0) was estimated for the interobserver agreement for the diagnosis of hyperplastic polyp vs. adenoma. The agreement in the diagnosis of tubular, tubulovillous, and villous type, was given by median kappa values of 0.50, 0.15, and 0.36, respectively. The median kappa for the diagnosis of infiltrating carcinoma was 0.78 (range 0.73-0.84). Agreement on diagnosis of adenoma histologic subtypes, degrees of dysplasia, or infiltrating carcinoma in adenoma was moderate. A simpler classifications might help to better identify patients at different risk of colorectal cancer.

Colorectal Cancer: Late Presentation and Outcome of Treatment ...

African Journals Online (AJOL)

Background: Colorectal cancer remains a major health problem especially in developed countries where it ranks as the third most common cause of cancer in both men and women. Though incidence of colorectal cancer is low in Nigeria and other developing countries, outcome of treatment remains poor due largely to late ...

Temporary metal internal stent dilation for colorectal obstruction and effect on operation methods

International Nuclear Information System (INIS)

Chen Niwei; Cheng Yingsheng; Fan Youben; Jin Huimin; Xu Huimin

2005-01-01

Objective: To explore the methods and clinical value of temporary internal metal stent through endoscopy under X ray control for treating patients with malignant colorectal obstruction. Methods: 27 patients with malignant colorectal obstruction were treated by temporary metallic internal stent placement via endoscopy under the X ray guidance. Results: 27 patients with colorectal obstruction symptoms were all got rid of the trouble within 48 hours after the stent placement. Selective stage I colorectal cancer resection and anastomosis were performed after bowel preparation. Conclusions: Metallic internal stent placement can loosen the colorectal obstructive symptoms with higher successful rate via endoscopy under X ray control and furthermore for promotion of stage I colorectal cancer resection and anastomosis. (authors)

Ziv-aflibercept in metastatic colorectal cancer

Directory of Open Access Journals (Sweden)

Patel A

2013-12-01

Full Text Available Anuj Patel, Weijing Sun Division of Hematology-Oncology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Abstract: The combination of cytotoxic chemotherapy and antiangiogenic agents has become a conventional treatment option for patients with metastatic colorectal cancer. Ziv-aflibercept is a fusion protein which acts as a decoy receptor for vascular endothelial growth factor (VEGF-A, VEGF-B, and placental growth factor (PlGF; it was approved in combination with 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI for the treatment of patients with metastatic colorectal cancer that is resistant to or has progressed after an oxaliplatin-containing fluoropyrimidine-based regimen. Herein we review the role of tumor angiogenesis as the rationale for antiangiogenic therapy, the clinical data associated with ziv-aflibercept, and its current role as a treatment option compared to other antiangiogenic agents, such as bevacizumab and regorafenib. Keywords: aflibercept, angiogenesis, colorectal cancer

Management of colorectal trauma: a review.

Science.gov (United States)

Cheong, Ju Yong; Keshava, Anil

2017-07-01

Traumatic colorectal injuries are common during times of military conflict, and major improvements in their care have arisen in such periods. Since World War II, many classification systems for colorectal trauma have been proposed, including (i) Flint Grading System; (ii) Penetrating Abdominal Trauma Index; (iii) Colonic/Rectal Injury Scale; and (iv) destructive/non-destructive colonic injuries. The primary goal of these classifications was to aid surgical management and, more particularly, to determine whether a primary repair or faecal diversion should be performed. Primary repair is now the preferred surgical option. Patients who have been identified as having destructive injuries have been found to have higher anastomotic leak rates after a primary repair. Damage control principles need to be adhered to in surgical decision-making. In this review, we discuss the mechanisms of injury, classifications, clinical presentation and current recommendations for the management of colorectal trauma. © 2017 Royal Australasian College of Surgeons.

EL PLANETA TIERRA COMO UN RECEPTÁCULO DE VIDA: ¿UN PLANETA CORRIENTE O UNA RAREZA EN EL UNIVERSO?

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Jose Gregorio Portilla Barbosa

2011-09-01

Full Text Available RESUMEN La vida está basada en elementos químicos que en su mayoría tienen su origen en el interior estelar. Luego las moléculas orgánicas se forman en el medio interestelar y pueden terminar en planetas aptos para la creación y prosperidad de la vida. Los planetas extrasolares, ahora detectados por los astrónomos, son bastante abundantes, pero aun así la vida extraterrestre parece ser escasa o cuanto al menos lo es la vida compleja. Un auténtico enigma es el hecho de que aun no se haya hecho contacto con civilizaciones extraterrestres. Palabras clave: vida, vida extraterrestre, exoplanetas.

[Initial experience in robot-assisted colorectal surgery in Mexico].

Science.gov (United States)

Villanueva-Sáenz, Eduardo; Ramírez-Ramírez, Moisés Marino; Zubieta-O'Farrill, Gregorio; García-Hernández, Luis

Colorectal surgery has advanced notably since the introduction of the mechanical suture and the minimally invasive approach. Robotic surgery began in order to satisfy the needs of the patient-doctor relationship, and migrated to the area of colorectal surgery. An initial report is presented on the experience of managing colorectal disease using robot-assisted surgery, as well as an analysis of the current role of this platform. A retrospective study was conducted in order to review five patients with colorectal disease operated using a robot-assisted technique over one year in the initial phase of the learning curve. Gender, age, diagnosis and surgical indication, surgery performed, surgical time, conversion, bleeding, post-operative complications, and hospital stay, were analysed and described. A literature review was performed on the role of robotic assisted surgery in colorectal disease and cancer. The study included 5 patients, 3 men and 2 women, with a mean age of 62.2 years. Two of them were low anterior resections with colorectal primary anastomoses, one of them extended with a loop protection ileostomy, a Frykman-Goldberg procedure, and two left hemicolectomies with primary anastomoses. The mean operating time was 6hours and robot-assisted 4hours 20minutes. There were no conversions and the mean hospital stay was 5 days. This technology is currently being used worldwide in different surgical centres because of its advantages that have been clinically demonstrated by various studies. We report the first colorectal surgical cases in Mexico, with promising results. There is enough evidence to support and recommend the use of this technology as a viable and safe option. Copyright © 2016 Academia Mexicana de Cirugía A.C. Publicado por Masson Doyma México S.A. All rights reserved.

Iranian dietary patterns and risk of colorectal cancer.

Science.gov (United States)

Azizi, Hosein; Asadollahi, Khairollah; Davtalab Esmaeili, Elham; Mirzapoor, Mohammad

2015-01-01

Role of diet on colorectal cancer (CRC) has been considered in terms of single foods and nutrients, but less frequently in terms of dietary patterns in Iran. The objective of this study was to determine the association between Iranian dietary patterns and CRC. This case-control study was conducted in four hospitals in Tabriz City of Iran including 414 participants aged 35-75 years:207 cases with CRC confirmed by pathology and colonoscopy findings were selected and 207 controls free of neoplastic conditions and diet-related chronic diseases (from the same hospital at the same period for the cases). Dietary data were assessed using a 123-item semi-quantitative food frequency questionnaire. Two dietary patterns were found by using of Principal Component Analysis (PCA) method;"Healthy pattern"and "Iranian pattern". Multivariate logistic regression analysis was used to estimate adjusted odds ratios (OR) for relationship between dietary patterns and colorectal cancer. After adjusting for confounding factors, the Iranian dietary pattern was significantly associated with an increased odds of colorectal cancer (OR= 1.46; 95% Confidenec Interval (CI)=1.05-2.19) while a reduced odds of colorectal cancer was observed with the Healthy dietary pattern (OR=0.18; 95% CI= 0.091-0.47). Iranian dietary pattern (IDP) seems to increase the odds of colorectal cancer and protective effect of Healthy dietary pattern.

Antimicrobial prophylaxis in colorectal surgery: focus on ertapenem

Directory of Open Access Journals (Sweden)

Fausto de Lalla

2009-10-01

Full Text Available Fausto de LallaLibero Docente of Infectious Diseases, University of Milano, Milano, ItalyAbstract: Despite improvement in infection control measures and surgical practice, surgical site infections (SSIs remain a major cause of morbidity and mortality. In colorectal surgery, perioperative administration of a suitable antimicrobial regimen that covers both anaerobic and aerobic bacteria is universally accepted. In a prospective, double-blind, randomized study ertapenem was recently found to be more effective than cefotetan, a parenteral cephalosporin so broadly used as to be considered as gold standard in the prevention of SSIs following colorectal surgery. In this adequate and well controlled study, the superiority of ertapenem over cefotetan was clearly demonstrated from the clinical and bacteriological points of view. However, data that directly compares ertapenem with other antimicrobial regimen effective in preventing SSIs following colorectal surgery are lacking; furthermore, the possible risk of promotion of carbapenem resistance associated with widespread use of ertapenem prophylaxis as well as the ertapenem effects on the intestinal gut flora are of concern. Further comparative studies of ertapenem versus other widely used prophylactic regimens for colorectal surgery in patients submitted to mechanical bowel preparation versus no preparation as well as further research on adverse events of antibiotic prophylaxis, including emergence of resistance and Clostridium difficile infection, seem warranted.Keywords: colorectal surgery, surgical prophylaxis, ertapenem

La calidad de vida de los sujetos usuarios de un centro social de personas mayores

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César Bugallo Carrera

2014-09-01

Full Text Available En esta investigación hemos intentado comprobar si la asistencia a los centros sociales de personas mayores es un medio eficaz para la mejora de la calidad de vida de las personas mayores, es decir, si los usuarios de dichos centros tienen una mejor calidad de vida que aquellos que no acuden a ellos. Para ello, hemos contado con un grupo experimental y un grupo control. A continuación ambos grupos han pasado dos pruebas: una que valora la calidad de vida y otra, el deterioro cognitivo. Una vez pasadas las pruebas y obtenidas las puntuaciones, hemos concluido que los usuarios del centro social tienen una mayor calidad de vida que los sujetos que no acuden a él.

Role of β1-Integrin in Colorectal Cancer: Case-Control Study

Science.gov (United States)

Oh, Bo-Young; Kim, Kwang Ho; Chung, Soon Sup; Hong, Kyoung Sook

2014-01-01

Purpose In the metastatic process, interactions between circulating tumor cells (CTCs) and the extracellular matrix or surrounding cells are required. β1-Integrin may mediate these interactions. The aim of this study was to investigate whether β1-integrin is associated with the detection of CTCs in colorectal cancer. Methods We enrolled 30 patients with colorectal cancer (experimental group) and 30 patients with benign diseases (control group). Blood samples were obtained from each group, carcinoembryonic antigen (CEA) mRNA for CTCs marker and β1-integrin mRNA levels were estimated by using reverse transcription-polymerase chain reaction, and the results were compared between the two groups. In the experimental group, preoperative results were compared with postoperative results for each marker. In addition, we analyzed the correlation between the expressions of β1-integrin and CEA. Results CEA mRNA was detected more frequently in colorectal cancer patients than in control patients (P = 0.008). CEA mRNA was significantly reduced after surgery in the colorectal cancer patients (P = 0.032). β1-Integrin mRNA was detected more in colorectal cancer patients than in the patients with benign diseases (P < 0.001). In colorectal cancer patients, expression of β1-integrin mRNA was detected more for advanced-stage cancer than for early-stage cancer (P = 0.033) and was significantly decreased after surgery (P < 0.001). In addition, expression of β1-integrin mRNA was significantly associated with that of CEA mRNA in colorectal cancer patients (P = 0.001). Conclusion In conclusion, β1-integrin is a potential factor for forming a prognosis following surgical resection in colorectal cancer patients. β1-Integrin may be a candidate for use as a marker for early detection of micrometastatic tumor cells and for monitoring the therapeutic response in colorectal cancer patients. PMID:24851215

Dietary patterns and colorectal adenomas in Lynch syndrome: the GEOLynch cohort study

NARCIS (Netherlands)

Botma, A.; Vasen, H.F.; Duijnhoven, F.J.B. van; Kleibeuker, J.H.; Nagengast, F.M.; Kampman, E.

2013-01-01

BACKGROUND: Patients with Lynch syndrome (LS) have a high risk of developing colorectal cancer due to mutations in mismatch repair genes. Because dietary factors, alone and in combination, influence sporadic colorectal carcinogenesis, the association of dietary patterns with colorectal adenomas in

Dietary Patterns and Colorectal Adenomas in Lynch Syndrome: The GEOLynch Cohort Study

NARCIS (Netherlands)

Botma, A.; Vasen, H.F.; Duijnhoven, van F.J.B.; Kleibeuker, J.H.; Nagengast, F.M.; Kampman, E.

2013-01-01

BACKGROUND: Patients with Lynch syndrome (LS) have a high risk of developing colorectal cancer due to mutations in mismatch repair genes. Because dietary factors, alone and in combination, influence sporadic colorectal carcinogenesis, the association of dietary patterns with colorectal adenomas in

Dietary Patterns and Colorectal Adenomas in Lynch Syndrome The GEOLynch Cohort Study

NARCIS (Netherlands)

Botma, Akke; Vasen, Hans F. A.; van Duijnhoven, Franzel J. B.; Kleibeuker, Jan H.; Nagengast, Fokko M.; Kampman, Ellen

2013-01-01

BACKGROUND: Patients with Lynch syndrome (LS) have a high risk of developing colorectal cancer due to mutations in mismatch repair genes. Because dietary factors, alone and in combination, influence sporadic colorectal carcinogenesis, the association of dietary patterns with colorectal adenomas in

Dietary patterns and colorectal cancer risk: a meta-analysis.

Science.gov (United States)

Feng, Yu-Liang; Shu, Long; Zheng, Pei-Fen; Zhang, Xiao-Yan; Si, Cai-Juan; Yu, Xiao-Long; Gao, Wei; Zhang, Lun

2017-05-01

The analysis of dietary patterns has recently drawn considerable attention as a method of investigating the association between the overall whole diet and the risk of colorectal cancer. However, the results have yielded conflicting findings. Here, we carried out a meta-analysis to identify the association between dietary patterns and the risk of colorectal cancer. A total of 40 studies fulfilled the inclusion criteria and were included in this meta-analysis. The highest category of 'healthy' dietary pattern compared with the lowest category was apparently associated with a decreased risk for colorectal cancer [odds ratio (OR)=0.75; confidence interval (CI): 0.68-0.83; Pcolorectal cancer was shown for the highest compared with the lowest category of a 'western-style' dietary pattern (OR=1.40; CI: 1.26-1.56; Pcolorectal cancer in the highest compared with the lowest category of 'alcohol-consumption' pattern (OR=1.44; CI: 1.13-1.82; P=0.003). The results of this meta-analysis indicate that a 'healthy' dietary pattern may decrease the risk of colorectal cancer, whereas 'western-style' and 'alcohol-consumption' patterns may increase the risk of colorectal cancer.

Religiosidade e estilo de vida de uma população adulta

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Marli Rosangela Cres

2015-06-01

Full Text Available Objetivo: Caracterizar o perfil de religiosidade e estilo de vida de uma população adulta e analisar a associação entre essas variáveis. Métodos: Pesquisa descritiva, transversal e quantitativa, realizada com participantes (n=206 de duas Feiras de Saúde na cidade de São Paulo, em 20/10/2013 e 04/05/2014. Aplicaram-se dois instrumentos, o Duke University Religion Index (DUREL, subdividido nas dimensões Religiosidade Organizacional, Não Organizacional e Intrínseca e o Estilo de Vida FANTÁSTICO. Realizaram-se os testes Rho de Spearman para associação das variáveis “estilo de vida” e “religiosidade”, e Qui-Quadrado para análise bivariada entre sexo e religiosidade. Resultados: Encontrou-se perfil de religiosidade predominantemente bom nas três dimensões, com destaque para a Religiosidade Intrínseca, que alcançou 83,5% (n=167 nos três quesitos. Quanto ao estilo de vida (FANTÁSTICO, obteve-se a classificação de: 26,6% (n=34 “Bom”, 48,4% (n=62 “Muito Bom” e 12,5% (n=16 “Excelente”. Das 125 análises bivariadas, 13 (11,3% apresentaram correlação fraca (ρ< 0,30, porém significativa (p<0,05. Nas associações do Qui-Quadrado, a religiosidade se relacionou às dimensões do estilo de vida quanto ao uso de álcool e drogas, alimentação equilibrada e saúde mental. Conclusão: A religiosidade na população estudada, considerando-se as três dimensões analisadas, caracterizou-se como “boa” e “muito boa”; e o estilo de vida, segundo escore total do questionário FANTÁSTICO, pôde ser considerado saudável. Apesar de fraca, confirmou-se associação entre a religiosidade e o estilo de vida.

Calidad de vida: panorámica de investigaciones clínicas

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Geraldine V. Padilla

2005-01-01

Full Text Available Este informe proporciona una panorámica de investigaciones clínicas pertenecientes a los estudios de la calidad de vida relacionada con la salud (CDVRS incluyendo cuestiones sobre el significado de la calidad de vida en la atención sanitaria, campos y definiciones conceptuales, teorías, definiciones operacionales, la relevancia clínica de resultados estadísticos significativos, y la relación entre investigación clínica, práctica clínica, valoraciones de CDVRS y resultados de CDVRS. Se revisan campos no directamente pertenecientes a la CDVRS y definiciones generales así como los campos y definiciones de la CDVRS. Las teorías y modelos presentados distinguen entre predictores y resultados de calidad de vida. Se describen unas pocas medidas de calidad de vida útiles y bien conocidas, así como útiles depósitos de cuestionarios en páginas web. El concepto de diferencia mínima clínicamente importante proporciona una estrategia para determinar la significación clínica de la significación estadística y más allá de ella. Finalmente se ofrece un modelo basado en la relación cuidador-paciente para explicar la influencia de la investigación clínica en la conducta clínica y los resultados de CDVRS.

Primary prevention of colorectal cancer: are we closer to reality?

LENUS (Irish Health Repository)

Qasim, Asghar

2012-02-01

Colorectal cancer is one of the leading causes of morbidity and mortality worldwide. An early detection of colorectal cancer determines therapeutic outcomes, while primary prevention remains a challenge. Our aim was to review the dietary, geographical and genetic factors in the causation and their possible role in the primary prevention of colorectal cancer. Data from experimental and clinical studies and population screening programmes were analysed to determine the factors responsible for causation of colorectal cancer. The role of dietary constituents, including the consumption of fat, red meat, fibre content, alcohol consumption, and other lifestyle issues, including obesity, lack of exercise and geographical variations in cancer prevalence were reviewed. The role of genetic and lifestyle factors in causation of colorectal cancer is evident from the experimental, clinical and population-based studies. Dietary factors, including the consumption of fat, fibre, red meat and alcohol, seem to have a significant influence in this regard. The role of micronutrients, vitamins, calcium may be relevant but remain largely unclear. In conclusion, there is ample evidence favouring the role of various dietary and lifestyle factors in the aetiology of colorectal cancer. Modification of these factors is an attractive option, which is likely to help in the primary prevention and reduced disease burden.

Clinical and pathological characteristics of colorectal polyps in ...

African Journals Online (AJOL)

Background & Aim: Colon polyps are important lesions and a concern because of the potential for colorectal cancer. Colorectal carcinoma is one of the most common causes of cancer-related deaths in Iranian population. The distribution of polyps in the colon may affect the efficacy of a screening modality. The aim of this ...

Satisfação com a Vida na Percepção dos Idosos

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Luciane Cristina Joia

2014-03-01

Full Text Available Foi realizada uma pesquisa qualitativa à luz da Grounded Theory, objetivando compreender os fatores associados à satisfação com a vida, em idosos, no município de Barreiras (BA. A metodologia escolhida foi qualitativa. Como pergunta norteadora, foi solicitado ao entrevistado que falasse espontaneamente sobre satisfação com a vida. Foram entrevistados vinte e um idosos, escolhidos por conveniência, provenientes de classes socioeconômicas e culturais e idades diversificadas. As entrevistas foram gravadas e registradas em mp3 e o conteúdo transcrito na íntegra. A análise dos dados foi realizada à luz da teoria fundamentada em dados (Grounded Theory e representada através do Simbolismo Teórico. Os resultados estão representados na descrição de três fenômenos que se integraram e interrelacionaram ao longo da experiência vivida, no que tange à satisfação com a vida. Estes constituíram os vértices na base do tripé que convergiram para o que aparenta ser o sentido da satisfação com a vida, entre eles: “Elegendo as Relações de Afeto e Cumplicidade com a Família, Amigos e Lazer”; “Encontrando a Felicidade na Vida, como a Construiu”; “Compreendendo as Condições de Saúde e as Necessidades da sua Prevenção como seus Determinantes”. Desse modo, a satisfação com a vida entre os idosos não apareceu apenas como um recorte de um ponto específico, mas sim como uma trajetória ao longo da vida que lhes proporcionou momentos de felicidade, atitudes e vontades, indo além dos desdobramentos e implicações que a idade avançada lhes reserva. Depois de descobertos esses fenômenos, buscamos padrões de conectividade entre seus componentes para conceitualizar a categoria central e conseguimos entender os pontos-chave que nos permitiram retratar a experiência dos idosos do município de Barreiras (BA, durante sua vida, associada com o grau de satisfação.  

Perfil de saúde e qualidade de vida de idosas com hipertensão arterial sistêmica

OpenAIRE

Gabriela Freire de Almeida Vitorino; Mayara Inácio de Oliveira; Hirla Vanessa Soares de Araújo; Rebeka Maria de Oliveira Belo; Thaisa Remigio Figueirêdo; Simone Maria Muniz da Silva Bezerra

2015-01-01

Objetivo: evaluar la calidad de vida de ancianas hipertensas en la Estrategia de Salud Familiar. Métodos: estudio transversal, descriptivo y cuantitativo, evaluó 60 ancianas hipertensas utilizándose la herramienta de la Organización Mundial de la Salud Calidad de Vida, con 26 artículos divididos en cuatro ámbitos: relaciones sociales, psicológico, físico y medio ambiente. Resultados: cuanto a la calidad de vida en todas las áreas, excepto en el dominio psicológico, calidad de vida se consider...

Quality of life and its determinants among colorectal cancer survivors

OpenAIRE

Hossein Ali Nikbakht; Nayyereh Amini Sani; Mohamad Asghari Jafarabadi; Seyed Reza Hosseini

2015-01-01

Background: Colorectal cancer has a significant impact on physical, mental and social discomfort of patients. The aim of this study was to assess different aspects of health-related quality of life and its association with demographic characteristics and some clinical features in colorectal cancer survivors in the city of Babol. Methods: This cross-sectional study was conducted in 2013 among 120 colorectal cancer survivors identified in the cancer registry from 2007 to 2012. A questionnair...

Colorectal anastomotic leakage: Aspects of prevention, detection and treatment

NARCIS (Netherlands)

F. Daams (Freek); M. Luyer (Misha); J.F. Lange (Johan)

2013-01-01

textabstractAll colorectal surgeons are faced from time to time with anastomotic leakage after colorectal surgery. This complication has been studied extensively without a significant reduction of incidence over the last 30 years. New techniques of prevention, by innovative anastomotic techniques

Contactos con la vida material en Zamora : siglos XII-XV

OpenAIRE

Bueno Domínguez, María Luisa

2005-01-01

El artículo trata de hacer una aproximación a la ciudad de Zamora desde tres puntos de vista. Por una parte, el paulatino ensanchamiento del espacio urbano en función de las pueblas, me he centrado en aquellas que me permitían ofrecer datos más concretos con respecto a la vida de una ciudad medieval en este caso Zamora. Acercándome a los lugares privados, las casas y a los públicos, calles y plazas por donde las personas realizaban su vida cotidiana. En un segundo apartado se hace una valorac...

Implications of preoperative hypoalbuminemia in colorectal surgery.

OpenAIRE

Truong, A; Hanna, MH; Moghadamyeghaneh, Z; Stamos, MJ

2016-01-01

Serum albumin has traditionally been used as a quantitative measure of a patient’s nutritional status because of its availability and low cost. While malnutrition has a clear definition within both the American and European Societies for Parenteral and Enteral Nutrition clinical guidelines, individual surgeons often determine nutritional status anecdotally. Preoperative albumin level has been shown to be the best predictor of mortality after colorectal cancer surgery. Specifically in colorect...

Avaliação da qualidade de vida e vulnerabilidade ao estresse no contexto hospitalar

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Fernanda Ottati

2013-05-01

Full Text Available O conceito de Qualidade de Vida é usado para medir as condições de vida de um ser humano, já a palavra vulnerabilidade refere-se à chance das pessoas estarem expostas ao adoecer. Objetivou-se analisar possíveis relações entre percepção de qualidade de vida e a vulnerabilidade ao estresse no trabalho em enfermeiros, técnicos e auxiliares de enfermagem que atuam na UTI e no setor de emergência de um hospital público. Utilizou-se o instrumento de qualidade de vida da Organização Mundial da Saúde, WHOQOL-Bref e a Escala de Vulnerabilidade ao Estresse no Trabalho. Encontrou-se, em relação ao setor de trabalho, diferença significativa apenas para Qualidade de vida total. Portanto pode-se afirmar que os profissionais que atuam na UTI possuem maior percepção de qualidade de vida quando comparados aos do SUS. Na correlação entre os dois instrumentos, o domínio meio ambiente do WHOQOL-Bref correlacionou-se negativa e significativamente com todos os fatores da EVENT, indicando que a percepção da pessoa em relação aos diversos aspectos do meio em que vive tem relação com a vulnerabilidade ao estresse.

Should We Pursue Patients Who Fail to Attend Colorectal Clinics? A 9-Year Study

Science.gov (United States)

John, SKP; Jones, OM; Fay, H; Howell, RD; Fozard, JBJ

2007-01-01

INTRODUCTION No uniform protocol exists on how to deal with patients who fail to attend colorectal clinics. Our aim was to identify whether the tendency to ‘failure to attend’ (FTA) in the colorectal clinic was associated with FTA in other clinics and also whether FTA patients have serious pathology. PATIENTS AND METHODS This was a retrospective study of a prospectively recorded list of FTA patients, in colorectal urgent or two-week wait clinics from 1996–2004. RESULTS A total of 151 patients, who failed to attend their first appointment, were included in the study. Of these, 61 (40.4%) were colorectal referrals, 76 (50.3%) were general surgical referrals, and for 14 (9.3%) case notes were not available. There were 59 FTA episodes in 61 colorectal patients associated with 59 FTA episodes in other clinics (Pearson correlation: r = 0.411; P = 0.01, two-tailed, SPSS v.12). Of 58 colorectal outcomes, five (8.6%) colorectal cancers (CRC) were diagnosed, 23 (39.6%) were persistent non-attendees, 16 (27.5%) had benign colorectal pathology, two (3.4%) benign non-colorectal outcomes and 12 (20.6%) normal outcomes. CONCLUSIONS Tendency to FTA is habitual. Care needs to be exercised in the management of FTAs to avoid delayed presentation of colorectal cancer. PMID:17688719

A blended knowledge translation initiative to improve colorectal cancer staging [ISRCTN56824239

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Ryan David P

2006-01-01

Full Text Available Abstract Background A significant gap has been documented between best practice and the actual practice of surgery. Our group identified that colorectal cancer staging in Ontario was suboptimal and subsequently developed a knowledge translation strategy using the principles of social marketing and the influence of expert and local opinion leaders for colorectal cancer. Methods/Design Opinion leaders were identified using the Hiss methodology. Hospitals in Ontario were cluster-randomized to one of two intervention arms. Both groups were exposed to a formal continuing medical education session given by the expert opinion leader for colorectal cancer. In the treatment group the local Opinion Leader for colorectal cancer was detailed by the expert opinion leader for colorectal cancer and received a toolkit. Forty-two centres agreed to have the expert opinion leader for colorectal cancer come and give a formal continuing medical education session that lasted between 50 minutes and 4 hours. No centres refused the intervention. These sessions were generally well attended by most surgeons, pathologists and other health care professionals at each centre. In addition all but one of the local opinion leaders for colorectal cancer met with the expert opinion leader for colorectal cancer for the academic detailing session that lasted between 15 and 30 minutes. Discussion We have enacted a unique study that has attempted to induce practice change among surgeons and pathologists using an adapted social marketing model that utilized the influence of both expert and local opinion leaders for colorectal cancer in a large geographic area with diverse practice settings.

Adult weight gain and colorectal adenomas-a systematic review and meta-analysis.

Science.gov (United States)

Schlesinger, S; Aleksandrova, K; Abar, L; Vieria, A R; Vingeliene, S; Polemiti, E; Stevens, C A T; Greenwood, D C; Chan, D S M; Aune, D; Norat, T

2017-06-01

Colorectal adenomas are known as precursors for the majority of colorectal carcinomas. While weight gain during adulthood has been identified as a risk factor for colorectal cancer, the association is less clear for colorectal adenomas. We conducted a systematic review and meta-analysis to quantify the evidence on this association. We searched Medline up to September 2016 to identify observational (prospective, cross-sectional and retrospective) studies on weight gain during adulthood and colorectal adenoma occurrence and recurrence. We conducted meta-analysis on high weight gain versus stable weight, linear and non-linear dose-response meta-analyses to analyze the association. Summary odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using a random effects model. For colorectal adenoma occurrence, the summary OR was 1.39 (95% CI: 1.17-1.65; I2: 43%, N = 9 studies, cases = 5507) comparing high (midpoint: 17.4 kg) versus stable weight gain during adulthood and with each 5 kg weight gain the odds increased by 7% (2%-11%; I2: 65%, N = 7 studies). Although there was indication of non-linearity (Pnon-linearity firm conclusions. Even a small amount of adult weight gain was related to a higher odds of colorectal adenoma occurrence. Our findings add to the benefits of weight control in adulthood regarding colorectal adenoma occurrence, which might be relevant for early prevention of colorectal cancer. © The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Vida artificial, el nuevo paradigma

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José Jesús Martínez Páez

1998-05-01

Full Text Available Se presenta una síntesis cronológica de los hechos más importantes en el desarrollo teórico y de simulación computacional, que han llevado a la formación de un nuevo paradigma que se conoce como vida artificial; se analizan sus características y sus príncipales líneas de investigación. Finalmente, se hace una descripción de su trabajo en la Universidad Nacional.

Male pattern baldness and risk of colorectal neoplasia.

Science.gov (United States)

Keum, N; Cao, Y; Lee, D H; Park, S M; Rosner, B; Fuchs, C S; Wu, K; Giovannucci, E L

2016-01-12

Male pattern baldness is positively associated with androgens as well as insulin-like growth factor 1 (IGF-1) and insulin, all of which are implicated in pathogenesis of colorectal neoplasia. From 1992 through 2010, we prospectively followed participants in the Health Professionals Follow-Up Study. Hair pattern at age 45 years was assessed at baseline with five image categories (no baldness, frontal-only baldness, frontal-plus-mild-vertex baldness, frontal-plus-moderate-vertex baldness, and frontal-plus-severe-vertex baldness). Cancer analysis included 32 782 men and used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Restricted to men who underwent at least one endoscopy over the study period, adenoma analysis included 29 770 men and used logistic regressions for clustered data to estimate odds ratios (ORs) and 95% CIs. Over the mean follow-up of 15.6 years, 710 cases of colorectal cancer (478 for colon, 152 for rectum, and 80 unknown site) developed. Significantly increased risks associated with frontal-only baldness and frontal-plus-mild-vertex baldness relative to no baldness were observed for colon cancer with respective HR being 1.29 (95% CI, 1.03-1.62) and 1.31 (95% CI, 1.01-1.70). Over the 19-year study period, 3526 cases of colorectal adenoma were detected. Evidence for an increased risk of colorectal adenoma relative to no baldness was significant with frontal-only baldness (OR, 1.16; 95% CI, 1.06-1.26) and borderline insignificant with frontal-plus-severe-vertex baldness (OR, 1.14; 95% CI, 0.98-1.33). Subtypes of male pattern baldness at age 45 years were positively associated with colorectal neoplasia. Future studies are warranted to confirm our results and to determine the predictive value of male pattern baldness to identify those at high risk for colorectal neoplasia.

COLORECTAL CANCER IN YOUNG INDIVIDUALS: AN OBSERVATIONAL STUDY

Directory of Open Access Journals (Sweden)

Mukesh Shanthilal

2016-07-01

Full Text Available INTRODUCTION Colorectal cancer is the third most common cancer which can be detected early by implementation of cancer screening. This has led to decline in colorectal cancer related morbidity and mortality in elderly patients. However, there is increase in the incidence of this cancer in young individuals. This study was undertaken to study the characteristics of young colorectal cancer patients. METHODS AND MATERIALS The study was conducted from 2014 to 2016. All colorectal cancer patients attending the Department of Oncology, who were less than or equal to 50 years of age were included. Patients’ demographic data as well as data regarding the colorectal cancer was collected. The data was entered into MS Excel worksheet and analysed using descriptive statistics. RESULTS This study included 28 patients with a median age of 40 years and equal sex distribution. History of smoking in 85.7% (12/14 and alcohol (moderate consumption in 64% (9/14 was present in male patients. There was no history of alcohol or smoking was present among female patients. However, tobacco chewing habit was present in 28% (4/14 of female patients. History of multiple sexual partners in 14% (4/28 of cases and 78% (22/28 were non-vegetarians. Nearly 85% (24/28 of patients presented with an advanced stage disease. The analysis showed involvement of left side of colon in 50% (14/28, rectum in 39% (11/28 and right side of colon in 11%(3/28. Except for two patients who were in stage - 1, all other patients received chemotherapy. CONCLUSION The incidence of colorectal cancer in young individuals is constantly rising. The reason for this increase is unclear and the relative contributions of genetic versus environmental factors remain relatively unexplored.

Diagnostic value of combined tumor markers detection for gastric and colorectal cancers

International Nuclear Information System (INIS)

Chen Wenzhang; Dong Lin

2007-01-01

Objective: To investigate the value of combined tumor markers detection in the clinical diagnosis for gastric cancer and colorectal cancel. Methods: The serum concentration of CEA, CA199, CA125, CA242 were measured by radioimmunoassay and Immunoradioassy in 46 patients with gastric cancer, 62 patients with colorectal cancer and 30 controls. Results: The diagnostic sensitivity, specificity, and accuracy of CEA were 37.0%, 96.7%, 59.2% respectively in gastric cancer,and 51.6%, 96.7%, 66.3% respectively in colorectal cancer, those of CA199 were 47.8%, 100.0%, 65.8% in gastric cancer, and 43.5%, 100.0%, 62, 0% in colorectal cancer, those of CA125 were 41.3%, 96.7%, 63.2% in gastric cancer, and 38.7%, 100.0%, 58.7% in colorectal cancer, those of CA242 were 54.3%, 100.0%, 71.5% in gastric cancer, and 51.6%, 100.0%, 67.4% in colorectal cancer. The diagnostic sensitivity specificity and accuracy of combined four markers were 73.9%, 93.3%, 82.9% in gastric cancer, and 77.4%, 96.7%, 83.7% in colorectal cancer. Compared with the respective value of any single marker, the diagnostic sensitivity and accuracy were significantly improved (P<0.05). Conclusion: Combined tumor markers detection could improve the diagnostic sensitivity and accuracy in gastric and colorectal cancers and was helpful for screening. (authors)

Potential role of probiotics on colorectal cancer prevention

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Uccello Mario

2012-11-01

Full Text Available Abstract Background Colorectal cancer represents the most common malignancy of the gastrointestinal tract. Owing to differences in dietary habits and lifestyle, this neoplasm is more common in industrialized countries than in developing ones. Evidence from a wide range of sources supports the assumption that the link between diet and colorectal cancer may be due to an imbalance of the intestinal microflora. Discussion Probiotic bacteria are live microorganisms that, when administered in adequate amounts, confer a healthy benefit on the host, and they have been investigated for their protective anti-tumor effects. In vivo and molecular studies have displayed encouraging findings that support a role of probiotics in colorectal cancer prevention. Summary Several mechanisms could explain the preventive action of probiotics against colorectal cancer onset. They include: alteration of the intestinal microflora; inactivation of cancerogenic compounds; competition with putrefactive and pathogenic microbiota; improvement of the host’s immune response; anti-proliferative effects via regulation of apoptosis and cell differentiation; fermentation of undigested food; inhibition of tyrosine kinase signaling pathways.

A batuta da morte a orquestrar a vida

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Altair Macedo Lahud Loureiro

Full Text Available Com colocações de outros estudiosos da morte, teço e apresento apontamentos rápidos sobre a morte a organizar a vida. Esposo a idéia da necessidade da morte para que a vida tenha sentido nesta busca humana da completude. Endereço o olhar para uma situação especial de relação com a morte: a reação dos que ficam ao presenciar e sentir a morte de um dos seus idosos; daquele familiar, ou não, que assume o seu cuidado e acompanha o seu fim iminente; que presencia, humanamente impotente, a hora da solitária partida. Solitária morte, pois que exclusiva, própria daquele idoso do qual cuidava, do seu fim natural, por ser humano.

Personalidades vocacionais e processos de carreira na vida adulta Personalidades vocacionales y procesos de carrera en la vida adulta Vocational personalities and career processes in adult life

OpenAIRE

Mauro de Oliveira Magalhães; William B. Gomes

2007-01-01

Esta pesquisa abordou a relação entre interesses vocacionais e os processos de comprometimento e entrincheiramento na carreira em diferentes fases da vida. Uma amostra de 733 profissionais (415 homens e 318 mulheres) respondeu a medidas de comprometimento e de entrincheiramento na carreira. Os sujeitos foram categorizados de acordo com o interesse vocacional predominante na tipologia de Holland. As análises revelaram interação entre estágio de vida e personalidade vocacional para os escores d...

Sarcopenia is associated with an increased risk of advanced colorectal neoplasia.

Science.gov (United States)

Park, Youn Su; Kim, Ji Won; Kim, Byeong Gwan; Lee, Kook Lae; Lee, Jae Kyung; Kim, Joo Sung; Koh, Seong-Joon

2017-04-01

Although sarcopenia is associated with an increased risk for mortality after the curative resection of colorectal cancer, its influence on the development of advanced colonic neoplasia remains unclear. This study included 1270 subjects aged 40 years or older evaluated with first-time screening colonoscopy at Seoul National University Boramae Health Care Center from January 2010 to February 2015. Skeletal muscle mass was measured with a body composition analyzer (direct segmental multifrequency bioelectrical impedance analysis method). Multiple logistic regression analysis was performed to determine whether sarcopenia is associated with advanced colorectal neoplasia. Of 1270 subjects, 139 (10.9%) were categorized into the sarcopenia group and 1131 (89.1%) into the non-sarcopenia group. In the non-sarcopenia group, 55 subjects (4.9%) had advanced colorectal neoplasia. However, in the sarcopenia group, 19 subjects (13.7%) had advanced colorectal neoplasia, including 1 subject with invasive colorectal cancer (0.7%). In addition, subjects with sarcopenia had a higher prevalence of advanced adenoma (P sarcopenia. According to the multiple logistic regression analysis adjusted for variable confounders, age (odds ratio 1.062, 95% confidence interval 1.032-1.093; P sarcopenia (odds ratio 2.347, 95% confidence interval 1.311-4.202; P = 0.004) were associated with an advanced colorectal neoplasia. Sarcopenia is associated with an increased risk of advanced colorectal neoplasia.

Vegetarian dietary patterns and the risk of colorectal cancers.

Science.gov (United States)

Orlich, Michael J; Singh, Pramil N; Sabaté, Joan; Fan, Jing; Sveen, Lars; Bennett, Hannelore; Knutsen, Synnove F; Beeson, W Lawrence; Jaceldo-Siegl, Karen; Butler, Terry L; Herring, R Patti; Fraser, Gary E

2015-05-01

Colorectal cancers are a leading cause of cancer mortality, and their primary prevention by diet is highly desirable. The relationship of vegetarian dietary patterns to colorectal cancer risk is not well established. To evaluate the association between vegetarian dietary patterns and incident colorectal cancers. The Adventist Health Study 2 (AHS-2) is a large, prospective, North American cohort trial including 96,354 Seventh-Day Adventist men and women recruited between January 1, 2002, and December 31, 2007. Follow-up varied by state and was indicated by the cancer registry linkage dates. Of these participants, an analytic sample of 77,659 remained after exclusions. Analysis was conducted using Cox proportional hazards regression, controlling for important demographic and lifestyle confounders. The analysis was conducted between June 1, 2014, and October 20, 2014. Diet was assessed at baseline by a validated quantitative food frequency questionnaire and categorized into 4 vegetarian dietary patterns (vegan, lacto-ovo vegetarian, pescovegetarian, and semivegetarian) and a nonvegetarian dietary pattern. The relationship between dietary patterns and incident cancers of the colon and rectum; colorectal cancer cases were identified primarily by state cancer registry linkages. During a mean follow-up of 7.3 years, 380 cases of colon cancer and 110 cases of rectal cancer were documented. The adjusted hazard ratios (HRs) in all vegetarians combined vs nonvegetarians were 0.78 (95% CI, 0.64-0.95) for all colorectal cancers, 0.81 (95% CI, 0.65-1.00) for colon cancer, and 0.71 (95% CI, 0.47-1.06) for rectal cancer. The adjusted HR for colorectal cancer in vegans was 0.84 (95% CI, 0.59-1.19); in lacto-ovo vegetarians, 0.82 (95% CI, 0.65-1.02); in pescovegetarians, 0.57 (95% CI, 0.40-0.82); and in semivegetarians, 0.92 (95% CI, 0.62-1.37) compared with nonvegetarians. Effect estimates were similar for men and women and for black and nonblack individuals. Vegetarian diets are

Colorectal cancer cells suppress CD4+ T cells immunity through canonical Wnt signaling.

Science.gov (United States)

Sun, Xuan; Liu, Suoning; Wang, Daguang; Zhang, Yang; Li, Wei; Guo, Yuchen; Zhang, Hua; Suo, Jian

2017-02-28

Understanding how colorectal cancer escapes from immunosurveillance and immune attack is important for developing novel immunotherapies for colorectal cancer. In this study we evaluated the role of canonical Wnt signaling in the regulation of T cell function in a mouse colorectal cancer model. We found that colorectal cancer cells expressed abundant Wnt ligands, and intratumoral T cells expressed various Frizzled proteins. Meanwhile, both active β-catenin and total β-catenin were elevated in intratumoral T cells. In vitro study indicated that colorectal cancer cells suppressed IFN-γ expression and increased IL-17a expression in activated CD4+ T cells. However, the cytotoxic activity of CD8+ T cells was not altered by colorectal cancer cells. To further evaluate the importance of Wnt signaling for CD4+ T cell-mediated cancer immunity, β-catenin expression was enforced in CD4+ T cells using lentiviral transduction. In an adoptive transfer model, enforced expression of β-catenin in intratumoral CD4+ T cells increased IL-17a expression, enhanced proliferation and inhibited apoptosis of colorectal cancer cells. Taken together, our study disclosed a new mechanism by which colorectal cancer impairs T cell immunity.

Acuidade olfatória e qualidade de vida após a laringectomia total

OpenAIRE

Christiane Gouvêa dos Santos; Anke Bergmann; Kaliani Lima Coça; Angela Albuquerque Garcia; Tânia Cristina de Oliveira Valente

2015-01-01

RESUMO: Objetivo: identificar a prevalência e os fatores associados às alterações do olfato e descrever a qualidade de vida após a laringectomia total. Métodos: estudo transversal para avaliar a acuidade olfatória e a qualidade de vida de laringectomizados totais no Instituto Nacional de Câncer por meio da aplicação do Teste de Identificação do Olfato da Universidade da Pensilvânia, do Questionário de Qualidade de Vida da Universidade de Washington e do Questionário sobre a Acuidade Olfatór...

Assessment of rehabilitation needs in colorectal cancer treatment

DEFF Research Database (Denmark)

Wiedenbein, Liza; Kristiansen, Maria; Adamsen, Lis

2016-01-01

clinical practices related to identification and documentation of rehabilitation needs among patients with colorectal cancer at Danish hospitals. Material and methods A retrospective clinical audit was conducted utilizing data from patient files randomly selected at surgical and oncology hospital...... departments treating colorectal cancer patients. Forty patients were included, 10 from each department. Semi-structured interviews were carried out among clinical nurse specialists. Audit data was analyzed using descriptive statistics, qualitative data using thematic analysis. Results Documentation...... rehabilitation services was documented among 5% (n = 2) of all patients. Assessments at surgical departments were shaped by the inherent continuous assessment of rehabilitation needs within standardized fast-track colorectal cancer surgery. In contrast, the implementation of locally developed assessment tools...

Obtención de plantas sanas de papa, Solanum tuberosum L. Variedad salentuna. A través de las técnicas de termoterapia y cultivo de meristemas in vitro.

Directory of Open Access Journals (Sweden)

Marulanda Aguirre Adriana

2001-09-01

Full Text Available Se obtuvieron plantas Super Elite de papa (Solanum tuberosum L., de la variedad regional Salentuna, catalogada como papa filia, implementando las técnicas de termoterapia, cultivo in vitro de meristemas y multiplicación acelerada. Se limpió esta variedad del complejo de enfermedades que la afectaban, para entregarle a los productores un material sano que los motive a regresar al campo con una alternativa de producción de mayor calidad y rentabilidad. La falta de semilla sana es una necesidad sentida por los agricultores del departamento de Caldas, pues hace más de treinta años que no se renueva el material vegetal y no existen programas de producción de semilla certificad de esta variedad en el país.

Influência de fatores socioeconômicos na qualidade de vida de idosos hipertensos

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João Marcus Oliveira Andrade

2014-08-01

Full Text Available O presente estudo teve como objetivo analisar a associação entre fatores socioeconômicos e qualidade de vida de idosos hipertensos atendidos pelo Programa Saúde da Família na cidade de Montes Claros, Minas Gerais, Brasil. Consistiu em um estudo transversal analítico conduzido em amostra representativa de 294 idosos hipertensos. Os dados foram coletados por meio de questionário de caracterização socioeconômica e de qualidade de vida (Minichal. Foram analisados por meio de testes não paramétricos de Mann-Witney e Kuskall-Wallis. Os resultados, por sua vez, mostraram que o estado conjugal, a religião e a escolaridade afetam de maneira estatisticamente significativa a qualidade de vida de idosos hipertensos. Idosos hipertensos solteiros/divorciados/viúvos, evangélicos, espíritas e pertencentes a outras entidades religiosas, e analfabetos apresentaram menores escores de qualidade de vida. Para as demais variáveis analisadas, não houve associação estatística. Conclui-se que os fatores socioeconômicos como estado conjugal, escolaridade e religião influenciam na qualidade de vida de idosos hipertensos.

Molecular alterations and biomarkers in colorectal cancer

Science.gov (United States)

Grady, William M.; Pritchard, Colin C.

2013-01-01

The promise of precision medicine is now a clinical reality. Advances in our understanding of the molecular genetics of colorectal cancer genetics is leading to the development of a variety of biomarkers that are being used as early detection markers, prognostic markers, and markers for predicting treatment responses. This is no more evident than in the recent advances in testing colorectal cancers for specific molecular alterations in order to guide treatment with the monoclonal antibody therapies cetuximab and panitumumab, which target the epidermal growth factor receptor (EGFR). In this review, we update a prior review published in 2010 and describe our current understanding of the molecular pathogenesis of colorectal cancer and how these alterations relate to emerging biomarkers for early detection and risk stratification (diagnostic markers), prognosis (prognostic markers), and the prediction of treatment responses (predictive markers). PMID:24178577

Third-line therapy for metastatic colorectal cancer

DEFF Research Database (Denmark)

Gundgaard, M.G.; Ehrnrooth, E.; Sørensen, Jens Benn

2008-01-01

BACKGROUND: The past years' therapy for colorectal cancer has evolved rapidly with the introduction of novel cytotoxic agents such as irinotecan, capecitabine and oxaliplatin. Further advances have been achieved with the integration of targeted agents such as bevacizumab, cetuximab and recently......, panitumumab. As a result, third-line treatment is now a necessary step in the optimal treatment of patients with metastatic colorectal cancer (MCRC). MATERIALS AND METHODS: We conducted a literature review of English language publications on third-line therapy for MCRC from January 2000 to April 2007. Data......OS of 16 months. With irinotecan and 5-FU, mOS around 8 months were reported and with cetuximab combined with irinotecan, the highest mOS was 9.8 months. CONCLUSION: Third-line therapy in advanced colorectal cancer may improve mOS for patients with MCRC. Therefore, randomized studies should be conducted...

Radioimmunoguided surgery using the monoclonal antibody B72.3 in colorectal tumors

International Nuclear Information System (INIS)

Sickle-Santanello, B.J.; O'Dwyer, P.J.; Mojzisik, C.

1987-01-01

The authors have developed a hand-held gamma-detecting probe (GDP) for intraoperative use that improves the sensitivity of external radioimmunodetection. Radiolabeled monoclonal antibody (MAb) B72.3 was injected in six patients with primary colorectal cancer and 31 patients with recurrent colorectal cancer an average of 16 days preoperatively. The GDP localized the MAb B72.3 in 83 percent of sites. The technique, known as a radioimmunoguided surgery (RIGS) system did not alter the surgical procedure in patients with primary colorectal cancer but did alter the approach in 26 percent (8/31) of patients with recurrent colorectal cancer. Two patients avoided unnecessary liver resections and two underwent extraabdominal approaches to document their disease. The RIGS system may influence the short-term morbidity and mortality of surgery for colorectal cancer. Larger series and longer follow-up are needed to determine whether the RIGS system confers a survival advantage to the patient with colorectal cancer

Advanced colorectal neoplasia risk stratification by penalized logistic regression.

Science.gov (United States)

Lin, Yunzhi; Yu, Menggang; Wang, Sijian; Chappell, Richard; Imperiale, Thomas F

2016-08-01

Colorectal cancer is the second leading cause of death from cancer in the United States. To facilitate the efficiency of colorectal cancer screening, there is a need to stratify risk for colorectal cancer among the 90% of US residents who are considered "average risk." In this article, we investigate such risk stratification rules for advanced colorectal neoplasia (colorectal cancer and advanced, precancerous polyps). We use a recently completed large cohort study of subjects who underwent a first screening colonoscopy. Logistic regression models have been used in the literature to estimate the risk of advanced colorectal neoplasia based on quantifiable risk factors. However, logistic regression may be prone to overfitting and instability in variable selection. Since most of the risk factors in our study have several categories, it was tempting to collapse these categories into fewer risk groups. We propose a penalized logistic regression method that automatically and simultaneously selects variables, groups categories, and estimates their coefficients by penalizing the [Formula: see text]-norm of both the coefficients and their differences. Hence, it encourages sparsity in the categories, i.e. grouping of the categories, and sparsity in the variables, i.e. variable selection. We apply the penalized logistic regression method to our data. The important variables are selected, with close categories simultaneously grouped, by penalized regression models with and without the interactions terms. The models are validated with 10-fold cross-validation. The receiver operating characteristic curves of the penalized regression models dominate the receiver operating characteristic curve of naive logistic regressions, indicating a superior discriminative performance. © The Author(s) 2013.

Colorectal carcinogenesis: Review of human and experimental animal studies

Directory of Open Access Journals (Sweden)

Tanaka Takuji

2009-01-01

Full Text Available This review gives a comprehensive overview of cancer development and links it to the current understanding of tumorigenesis and malignant progression in colorectal cancer. The focus is on human and murine colorectal carcinogenesis and the histogenesis of this malignant disorder. A summary of a model of colitis-associated colon tumorigenesis (an AOM/DSS model will also be presented. The earliest phases of colorectal oncogenesis occur in the normal mucosa, with a disorder of cell replication. The large majority of colorectal malignancies develop from an adenomatous polyp (adenoma. These can be defined as well-demarcated masses of epithelial dysplasia, with uncontrolled crypt cell proliferation. When neoplastic cells pass through the muscularis mucosa and infiltrate the submucosa, they are malignant. Carcinomas usually originate from pre-existing adenomas, but this does not imply that all polyps undergo malignant changes and does not exclude de novo oncogenesis. Besides adenomas, there are other types of pre-neoplasia, which include hyperplastic polyps, serrated adenomas, flat adenomas and dysplasia that occurs in the inflamed colon in associated with inflammatory bowel disease. Colorectal neoplasms cover a wide range of pre-malignant and malignant lesions, many of which can easily be removed during endoscopy if they are small. Colorectal neoplasms and/or pre-neoplasms can be prevented by interfering with the various steps of oncogenesis, which begins with uncontrolled epithelial cell replication, continues with the formation of adenomas and eventually evolves into malignancy. The knowledge described herein will help to reduce and prevent this malignancy, which is one of the most frequent neoplasms in some Western and developed countries.

Calidad de vida en cuidadores informales de personas con enfermedades crónicas

Directory of Open Access Journals (Sweden)

José Hernando Ávila-Toscano

2014-01-01

Full Text Available Objetivo: evaluar la calidad de vida de cuidadores informales de personas que viven en situación de enfermedad crónica determi- nando si la misma se relaciona con las características sociodemográficas de los participantes. Materiales y métodos: se evaluaron 127 cuidadores informales residentes en Montería (Córdoba, Colombia, durante el segundo semestre de 2012, por medio de un diseño ex post facto con el cuestionario WHOQOL-Bref de la Organización Mundial de la Salud (OMS. Para la evaluación de calidad de vida se conside- raron cuatro dominios: a salud física, b salud psicológica, c relaciones sociales y d medioambiente. Los datos se analizaron con SPSS 18,0 aplicando chi cuadrado de Pearson y pruebas de diferencias entre grupos. Resultados: se observaron bajos niveles de salud física y psicológica, deterioro de los procesos de participación social y niveles moderados de interacción con el medioambiente. Condiciones como el género del cuidador, su ocupación y la relación con el paciente tuvieron una correspondencia significativa (p < 0,05 con la calidad de vida en relación con los dominios de medioambiente, vida social y salud psicológica. Conclusiones: los cuidadores informales presentan un deterioro general de su calidad de vida con déficit marcado en la esfera relacional.

OTX1 promotes colorectal cancer progression through epithelial-mesenchymal transition

International Nuclear Information System (INIS)

Yu, Kun; Cai, Xin-Yi; Li, Qiang; Yang, Zhi-Bin; Xiong, Wei; Shen, Tao; Wang, Wei-Ya; Li, Yun-Feng

2014-01-01

Highlights: • OTX1 is overexpression in colorectal cancer tissues. • Overexpression of OTX1 promotes colorectal cancer cell proliferation and invasion in vitro and tumor growth in vivo. • Depletion of OTX1 inhibits colorectal cancer cell proliferation and invasion in vitro. • Overexpression of OTX1 is linked to the EMT-like phenotype. - Abstract: Orthodenticle homeobox 1 (OTX1), a transcription factor containing a bicoid-like homeodomain, plays a role in brain and sensory organ development. In this study, we report that OTX1 is overexpressed in human colorectal cancer (CRC) and OTX1 overexpression is associated with higher stage. Functional analyses reveal that overexpression of OTX1 results in accumulation of CRC cell proliferation and invasion in vitro and tumor growth in vivo, whereas ablation of OTX1 expression significantly inhibits the proliferative and invasive capability of CRC cells in vitro. Together, our results indicate that OTX1 is involved in human colon carcinogenesis and may serve as a potential therapeutic target for human colorectal cancer

Dietary patterns and the risk of colorectal cancer and adenomas.

Science.gov (United States)

Randi, Giorgia; Edefonti, Valeria; Ferraroni, Monica; La Vecchia, Carlo; Decarli, Adriano

2010-07-01

The association of colorectal cancer risk with select foods has been evaluated by dietary pattern analysis. This review of the literature was conducted to thoroughly examine the available evidence for the association between dietary patterns and colorectal cancers and adenomas. A total of 32 articles based on worldwide epidemiological studies were identified. Pattern identification was achieved by exploratory data analyses (principal component, factor, and cluster analyses) in most articles, and only a few used a priori-defined scores. Dietary patterns named as healthy, prudent, fruit and vegetables, fat-reduced/diet foods, vegetable/fish/poultry, fruit/whole grain/dairy, and healthy eating index-2005, recommended food and Mediterranean diet scores were all associated with reduced risk of colorectal cancer and the risk estimates varied from 0.45 to 0.90. In contrast, diets named Western, pork-processed meat-potatoes, meat-eaters, meat and potatoes, traditional patterns, and dietary risk and life summary scores were associated with increased risk of colorectal cancer with risk estimates varying from 1.18 to 11.7. Dietary patterns for adenomas were consistent with those identified for colorectal cancer.

OTX1 promotes colorectal cancer progression through epithelial-mesenchymal transition

Energy Technology Data Exchange (ETDEWEB)

Yu, Kun; Cai, Xin-Yi; Li, Qiang; Yang, Zhi-Bin; Xiong, Wei; Shen, Tao; Wang, Wei-Ya; Li, Yun-Feng, E-mail: ynsliyunfeng@163.com

2014-01-31

Highlights: • OTX1 is overexpression in colorectal cancer tissues. • Overexpression of OTX1 promotes colorectal cancer cell proliferation and invasion in vitro and tumor growth in vivo. • Depletion of OTX1 inhibits colorectal cancer cell proliferation and invasion in vitro. • Overexpression of OTX1 is linked to the EMT-like phenotype. - Abstract: Orthodenticle homeobox 1 (OTX1), a transcription factor containing a bicoid-like homeodomain, plays a role in brain and sensory organ development. In this study, we report that OTX1 is overexpressed in human colorectal cancer (CRC) and OTX1 overexpression is associated with higher stage. Functional analyses reveal that overexpression of OTX1 results in accumulation of CRC cell proliferation and invasion in vitro and tumor growth in vivo, whereas ablation of OTX1 expression significantly inhibits the proliferative and invasive capability of CRC cells in vitro. Together, our results indicate that OTX1 is involved in human colon carcinogenesis and may serve as a potential therapeutic target for human colorectal cancer.

[Colorectal cancer (CCR): genetic and molecular alterations].

Science.gov (United States)

Juárez-Vázquez, Clara Ibet; Rosales-Reynoso, Mónica Alejandra

2014-01-01

The aim of this review is to present a genetic and molecular overview of colorectal carcinogenesis (sporadic and hereditary origin) as a multistage process, where there are a number of molecular mechanisms associated with the development of colorectal cancer and genomic instability that allows the accumulation of mutations in proto-oncogenes and tumor suppressor genes, chromosomal instability, and methylation and microsatellite instability, and the involvement of altered expression of microRNAs' prognosis factors.

Early results after robot-assisted colorectal surgery

DEFF Research Database (Denmark)

Eriksen, Jens Ravn; Helvind, Neel Maria; Jakobsen, Henrik Loft

2013-01-01

Implementation of robotic technology in surgery is challenging in many ways. The aim of this study was to present the implementation process and results of the first two years of consecutive robot-assisted laparoscopic (RAL) colorectal procedures.......Implementation of robotic technology in surgery is challenging in many ways. The aim of this study was to present the implementation process and results of the first two years of consecutive robot-assisted laparoscopic (RAL) colorectal procedures....

Meat consumption and colorectal cancer risk in Japan: The Takayama study.

Science.gov (United States)

Wada, Keiko; Oba, Shino; Tsuji, Michiko; Tamura, Takashi; Konishi, Kie; Goto, Yuko; Mizuta, Fumi; Koda, Sachi; Hori, Akihiro; Tanabashi, Shinobu; Matsushita, Shogen; Tokimitsu, Naoki; Nagata, Chisato

2017-05-01

Compared with the abundant data from Western countries, evidence regarding meat consumption and colorectal cancer is limited in the Japanese population. We evaluated colorectal cancer risk in relation to meat consumption in a population-based prospective cohort study in Japan. Participants were 13 957 men and 16 374 women aged ≥35 years in September 1992. Meat intake, assessed with a validated food frequency questionnaire, was controlled for the total energy intake. The incidence of colorectal cancer was confirmed through regional population-based cancer registries and histological identification from colonoscopy in two main hospitals in the study area. From September 1992 to March 2008, 429 men and 343 women developed colorectal cancer. After adjustments for multiple confounders, a significantly increased relative risk of colorectal cancer was observed in the highest versus lowest quartile of the intake of total and red meat among men; the estimated hazard ratios were 1.36 (95% CI: 1.03, 1.79) for total meat (P for trend = 0.022), and 1.44 (95% CI: 1.10, 1.89) for red meat (P for trend = 0.009). A positive association between processed meat intake and colon cancer risk was also observed in men. There was no significant association between colorectal cancer and meat consumption in women. These results suggest that the intake of red and processed meat increases the risk of colorectal or colon cancer among Japanese men. Abstaining from excessive consumption of meat might be protective against developing colorectal cancer. © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Alcohol consumption, alcohol dehydrogenase 3 polymorphism, and colorectal adenomas

NARCIS (Netherlands)

Tiemersma, E.W.; Wark, P.A.; Ocké, M.C.; Bunschoten, A.; Otten, M.H.; Kok, F.J.; Kampman, E.

2003-01-01

Alcohol is a probable risk factor with regard to colorectal neoplasm and is metabolized to the carcinogen acetaldehyde by the genetically polymorphic alcohol dehydrogenase 3 (ADH3) enzyme. We evaluated whether the association between alcohol and colorectal adenomas is modified by ADH3 polymorphism.

Patterns and presentations of colorectal cancer at Komfo-Anokye ...

African Journals Online (AJOL)

Introduction: Colorectal cancer is a major cause of morbidity and mortality globally and its incidence is increasing in developing countries. This study determined the incidence, clinical features and the histopathological patterns of colorectal cancer at Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana. Methods: A ...

Iranian Dietary Patterns and Risk of Colorectal Cancer

Directory of Open Access Journals (Sweden)

Hosein Azizi

2015-03-01

Full Text Available Background: Role of diet on colorectal cancer (CRC has been considered in terms of single foods and nutrients, but less frequently in terms of dietary patterns in Iran. The objective of this study was to determine the association between Iranian dietary patterns and CRC.Methods: This case–control study was conducted in four hospitals in Tabriz City of Iran including 414 participants aged 35–75 years:207 cases with CRC confirmed by pathology and colonoscopy findings were selected and 207 controls free of neoplastic conditions and diet-related chronic diseases (from the same hospital at the same period for the cases. Dietary data were assessed using a 123-item semi-quantitative food frequency questionnaire. Two dietary patterns were found by using of Principal Component Analysis (PCA method;“Healthy pattern”and “Iranian pattern”. Multivariate logistic regression analysis was used to estimate adjusted odds ratios (OR for relationship between dietary patterns and colorectal cancer.Results: After adjusting for confounding factors, the Iranian dietary pattern was significantly associated with an increased odds of colorectal cancer (OR= 1.46; 95% Confidenec Interval (CI=1.05–2.19 while a reduced odds of colorectal cancer was observed with the Healthy dietary pattern (OR=0.18; 95% CI= 0.091-0.47.Conclusion: Iranian dietary pattern (IDP seems to increase the odds of colorectal cancer and protective effect of Healthy dietary pattern.

The VIDA programme

DEFF Research Database (Denmark)

Jensen, Bente; Iannone, Rosa Lisa

and Innovation’ within the project ‘Curriculum Quality Analysis and Impact Review of European Education and Care’ (CARE). The programme at the centre of this case builds on theory drawn from research on child development, social disadvantage related to issues of social inequality, and research on organisational...... of innovation as “the development of new concepts, strategies and tools that support groups in achieving the objective of improved well-being”. Three research questions are explored: 1) How is the innovative approach to ECEC professional development conceptualised and translated into practice in the VIDA...... (mechanisms/aspects) affect the implementation of the innovative programme for practice change within ECEC? Methods used include a combination of qualitative data collected through interviews with ECEC educators, managers, consultants, a university college teachers, municipal directors and existing...