Sample records for victor hurst iv

  1. Memorial symposium for Victor Weisskopf.

    CERN Multimedia

    Maximilien Brice


    A memorial symposium for Victor Weisskopf, CERN Director-General from 1961 to 1965, was held at CERN on 17 September 2002. Photo 01: L. Maiani: Welcome.Photo 02: J. D. Jackson: Highlights from the career and scientific works of Victor F. Weisskopf.Photos 05 09: M. Hine and K. Johnsen: Working with Viki at CERN.Photo 10: M. Jacob: Knowledge and Wonder.Photo 14: K. Worth (Viki's daughter): Reminiscences.

  2. Broglie, Prof. Louis Victor de

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1951 Honorary. Broglie, Prof. Louis Victor de. Nobel Laureate (Physics) - 1929. Date of birth: 15 August 1892. Date of death: 19 March 1987. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. New Fellows and Honorary Fellow. Posted on 1 January 2018. List of Fellows ...

  3. Memorial Symposium for Victor Weisskopf

    CERN Document Server


    Victor 'Viki' Weisskopf, former Director General of CERN from 1961 to 1965, passed away five months ago. At that time, the Bulletin dedicated its coverpage to this brilliant physicist (19-20/2002). Now, CERN has organised a Memorial Symposium for next Tuesday 17 September, where you are cordially invited. This tribute will include the following speechs: L. Maiani: Welcome J. D. Jackson: Highlights from the career and scientific works of Victor F. Weisskopf M. Hine and K. Johnsen: Working with Viki at CERN M. Jacob: Knowledge and Wonder A member of Viki's family: Reminiscences. The Memorial Symposium will take place in the Main Auditorium at 15h. Drinks will be served in Pas Perdus at 17h 30.

  4. Hurst analysis of electricity price dynamics


    Rafal Weron; Beata Przybylowicz


    The price of electricity is extremely volatile, because electric power cannot be economically stored, end user demand is largely weather dependent, and the reliability of the grid is paramount. However, underlying the process of price returns is a strong mean-reverting mechanism. We study this feature of electricity returns by means of Hurst R/S analysis.

  5. Estimation of Hurst Exponent for the Financial Time Series (United States)

    Kumar, J.; Manchanda, P.


    Till recently statistical methods and Fourier analysis were employed to study fluctuations in stock markets in general and Indian stock market in particular. However current trend is to apply the concepts of wavelet methodology and Hurst exponent, see for example the work of Manchanda, J. Kumar and Siddiqi, Journal of the Frankline Institute 144 (2007), 613-636 and paper of Cajueiro and B. M. Tabak. Cajueiro and Tabak, Physica A, 2003, have checked the efficiency of emerging markets by computing Hurst component over a time window of 4 years of data. Our goal in the present paper is to understand the dynamics of the Indian stock market. We look for the persistency in the stock market through Hurst exponent and fractal dimension of time series data of BSE 100 and NIFTY 50.

  6. Clustering of Casablanca stock market based on hurst exponent estimates (United States)

    Lahmiri, Salim


    This paper deals with the problem of Casablanca Stock Exchange (CSE) topology modeling as a complex network during three different market regimes: general trend characterized by ups and downs, increasing trend, and decreasing trend. In particular, a set of seven different Hurst exponent estimates are used to characterize long-range dependence in each industrial sector generating process. They are employed in conjunction with hierarchical clustering approach to examine the co-movements of the Casablanca Stock Exchange industrial sectors. The purpose is to investigate whether cluster structures are similar across variable, increasing and decreasing regimes. It is observed that the general structure of the CSE topology has been considerably changed over 2009 (variable regime), 2010 (increasing regime), and 2011 (decreasing regime) time periods. The most important findings follow. First, in general a high value of Hurst exponent is associated to a variable regime and a small one to a decreasing regime. In addition, Hurst estimates during increasing regime are higher than those of a decreasing regime. Second, correlations between estimated Hurst exponent vectors of industrial sectors increase when Casablanca stock exchange follows an upward regime, whilst they decrease when the overall market follows a downward regime.

  7. Victor F. Weisskopf (1908 - 2002): Physikgeschichte (United States)

    Jacobi, Manfred


    Universal gebildete und interessierte Menschen sind selten geworden in unserer Zeit. Victor F. Weisskopf war einer von ihnen. Sein geistiger Horizont umfasste nicht nur sein eigentliches Fachgebiet, die Physik, wo er sich durch fundamentale Arbeiten in den Bereichen der Quantenfeldtheorie, der Kern- und Elementarteilchenphysik hervortat. Daneben bildeten Kunst und Musik sowie ein außergewöhnliches Engagement in sozialen und politischen Angelegenheiten die Eckpunkte seines Lebens. Der Einsatz für die Verständigung zwischen den Machtblöcken während des Kalten Krieges war für ihn ebenso selbstverständlich wie das Bedürfnis, die neuen Ideen der Physik einem breiten Publikum nahe zu bringen. Die Wissenschaft erschien ihm als das geeignete Mittel, um zum Wohle der Menschheit zu wirken.

  8. Victor Nikolaevich Shitov (1947–2013

    Directory of Open Access Journals (Sweden)

    Zeleneev Yuriy A.


    Full Text Available The article is dedicated to the memory of Victor Nikolaevich Shitov (October 1, 1947-October 31, 2013, who had been the intellectual leader of the archaeologists of the Republic of Mordovia for many years. The basic stages of his scientific biography are elucidated. The first independent studies conducted by V.N. Shitov were associated with the Shoksha burial ground referring to the Ryazan-Oka culture. Since then, the ancient Mordovian culture of the 1st millennium AD had been playing the dominant role in his studies. In 1976, V.N. Shitov became a research fellow of the sector of Archeology and Ethnography, the Mordovian Research Institute of language, literature, history and economics. The last period of his scientific activity was connected with the preparation and organizational work on the multi-volume edition “The archaeology of the Mordovian land”.

  9. Victor's justice: atrocities in postwar Nigeria. (United States)

    Omaka, Arua Oko


    The Nigerian Government's declaration of 'no victor, no vanquished' after the capitulation of Biafra on 12 January 1970, was applauded as the right step towards reconciliation and transition from war to peace. Despite this declaration and assurance of amnesty, the Nigerian Government and its soldiers still engaged in acts that amounted to retributive justice. They starved and killed innocent Biafran civilians, looted their property and raped their women. Surprisingly, these postwar atrocities committed against former Biafrans have been largely ignored in the historiography of the Nigeria-Biafra War. This paper seeks to fill the gap in the war literature by interrogating Nigerian Government's attitude towards the postwar humanitarian crisis and crimes against humanity in former Biafra. The paper argues that former Biafrans were not fully reintegrated into the Nigerian society and that the Nigerian Government deliberately neglected them to die in large numbers, thereby making it difficult for the war victims to recover from the hardships of the conflict.

  10. Revisiting the Decision of Death in Hurst v. Florida. (United States)

    Cooke, Brian K; Ginory, Almari; Zedalis, Jennifer


    The United States Supreme Court has considered the question of whether a judge or a jury must make the findings necessary to support imposition of the death penalty in several notable cases, including Spaziano v. Florida (1984), Hildwin v. Florida (1989), and Ring v. Arizona (2002). In 2016, the U.S. Supreme Court revisited the subject in Hurst v. Florida Florida Statute § 921.141 allows the judge, after weighing aggravating and mitigating circumstances, to enter a sentence of life imprisonment or death. Before Hurst, Florida's bifurcated sentencing proceedings included an advisory sentence from jurors and a separate judicial hearing without juror involvement. In Hurst, the Court revisited the question of whether Florida's capital sentencing scheme violates the Sixth Amendment, which requires a jury, not a judge, to find each fact necessary to impose a sentence of death in light of Ring In an eight-to-one decision, the Court reversed the judgment of the Florida Supreme Court, holding that the Sixth Amendment requires a jury to find the aggravating factors necessary for imposing the death penalty. The role of Florida juries in capital sentencing proceedings was thereby elevated from advisory to determinative. We examine the Court's decision and offer commentary regarding this shift from judge to jury in the final imposition of the death penalty and the overall effect of this landmark case. © 2016 American Academy of Psychiatry and the Law.

  11. Roberts Victor eclogites: ancient oceanic crust

    Energy Technology Data Exchange (ETDEWEB)

    MacGregor, I.D.


    New data on the oxygen isotopic chemistry of the oceanic crust and ophiolites illustrate the role of circulating seawater in changing the chemistry of aging oceanic crust. A similar range of oxygen isotope ratios in the eclogites suggests a comparable origin. The interpretation is consistent with the following observations: Whole rocks values of S /sup 18/O are negatively correlated with both the /sup 87///sup 86/Sr and K content. The internal whole rock correlations may be explained as a series of rocks that have undergone varying degrees of alteration on an ancient sea floor. Whole rock chemistry when recalculated to 1 atm. norms and compared with 1 atm. liquidus diagrams indicate two different groups of eclogites. One group has trends that are comparable to a series of liquids formed by the fractional crystallization of olivine followed by plagioclase and clinopyroxene while the other group correlate with cumulate assemblages of gabbroic composition. The REE chemistry of separated garnets and clinopyroxenes and whole rocks allow recalculation of the chemistry of the intergranular material which is significantly LREE enriched. K, Rb, Li and Ti are similarly enriched. The intergranular chemistry compares favorably with that of hypothesized mantle metasomatising fluids and is interpreted to evolve during the metamorphic transition to eclogite assemblages during subduction. The data allow for the interpretation that the Roberts Victor eclogite are relicts of at least 3.2 b.y. old oceanic crust and that the two different groups separately represent the volcanic and gabbroic rocks of the upper part of the ancient oceanic lithosphere.

  12. Markov vs. Hurst-Kolmogorov behaviour identification in hydroclimatic processes (United States)

    Dimitriadis, Panayiotis; Gournari, Naya; Koutsoyiannis, Demetris


    Hydroclimatic processes are usually modelled either by exponential decay of the autocovariance function, i.e., Markovian behaviour, or power type decay, i.e., long-term persistence (or else Hurst-Kolmogorov behaviour). For the identification and quantification of such behaviours several graphical stochastic tools can be used such as the climacogram (i.e., plot of the variance of the averaged process vs. scale), autocovariance, variogram, power spectrum etc. with the former usually exhibiting smaller statistical uncertainty as compared to the others. However, most methodologies including these tools are based on the expected value of the process. In this analysis, we explore a methodology that combines both the practical use of a graphical representation of the internal structure of the process as well as the statistical robustness of the maximum-likelihood estimation. For validation and illustration purposes, we apply this methodology to fundamental stochastic processes, such as Markov and Hurst-Kolmogorov type ones. Acknowledgement: This research is conducted within the frame of the undergraduate course "Stochastic Methods in Water Resources" of the National Technical University of Athens (NTUA). The School of Civil Engineering of NTUA provided moral support for the participation of the students in the Assembly.

  13. Hurst exponent and prediction based on weak-form efficient market hypothesis of stock markets (United States)

    Eom, Cheoljun; Choi, Sunghoon; Oh, Gabjin; Jung, Woo-Sung


    We empirically investigated the relationships between the degree of efficiency and the predictability in financial time-series data. The Hurst exponent was used as the measurement of the degree of efficiency, and the hit rate calculated from the nearest-neighbor prediction method was used for the prediction of the directions of future price changes. We used 60 market indexes of various countries. We empirically discovered that the relationship between the degree of efficiency (the Hurst exponent) and the predictability (the hit rate) is strongly positive. That is, a market index with a higher Hurst exponent tends to have a higher hit rate. These results suggested that the Hurst exponent is useful for predicting future price changes. Furthermore, we also discovered that the Hurst exponent and the hit rate are useful as standards that can distinguish emerging capital markets from mature capital markets.

  14. 378-IJBCS-Article-Kouamé Kouamé Victor

    African Journals Online (AJOL)

    User Physico-chemical factors involved in rivers and lagoons invasion by water hyacinth, Côte d'Ivoire. Victor Kouamé KOUAMÉ 1*, Ossey Bernard YAPO 1, Abiba Sanogo TIDOU-BOGA 1,. Véronique MAMBO 1, Arsène SEKA ...

  15. Victim and the victor: Humanism and new humanism in Chris ...

    African Journals Online (AJOL)

    On New Humanism and Broken Chains, the paper affirms that Humanity's dualism is the central tenet of New Humanism. The chains of fornication and adultery of victims like Dr Imasuen, Dr Osaze, Blossom, Daisy and Tonia were only broken and they became victors when they repented of their sins and accepted God's ...

  16. Obituary Professor Victor Weisskopf - atom-bomb and CERN physicist

    CERN Multimedia

    Dalyell, T


    The rise of Nazism brought horror, humiliation, death and torture to so many free-thinking people - Jews, and other minorities. There were some lucky ones, like the Weisskopf family, who were able to escape. Victor Weisskopf was born and brought up in Austria in the spirit of German culture and said that he considered his transfer from Europe to the USA an invaluable source of intellectual enrichment (2 pages).

  17. Electromagnetic scattering on fractional Brownian surfaces and estimation of the Hurst exponent


    Guérin, Charles-Antoine; Saillard, Marc


    International audience; Fractional Brownian motion is known to be a realistic model for many natural rough surfaces. It is defined by means of a single parameter, the Hurst exponent, which determines the fractal characteristics of the surface. We propose a method to estimate the Hurst exponent of a fractional Brownian profile from the electromagnetic scattering data. The method is developed in the framework of three usual approximations, with different domains of validity: the Kirchhoff appro...

  18. Possibility between earthquake and explosion seismogram differentiation by discrete stochastic non-Markov processes and local Hurst exponent analysis. (United States)

    Yulmetyev, R; Gafarov, F; Hänggi, P; Nigmatullin, R; Kayumov, S


    The basic scientific point of this paper is to draw the attention of researchers to new possibilities of differentiation of similar signals having different nature. One example of such kinds of signals is presented by seismograms containing recordings of earthquakes (EQ's) and technogenic explosions (TE's). EQ's are among the most dramatic phenomena in nature. We propose here a discrete stochastic model for possible solution of a problem of strong EQ forecasting and differentiation of TE's from the weak EQ's. Theoretical analysis is performed by two independent methods: by using statistical theory of discrete non-Markov stochastic processes [Phys. Rev. E 62, 6178 (2000)] and the local Hurst exponent. The following Earth states have been considered among them: before (Ib) and during (I) strong EQ, during weak EQ (II) and during TE (III), and in a calm state of Earth's core (IV). The estimation of states I, II, and III has been made on the particular examples of Turkey (1999) EQ's, state IV has been taken as an example of Earth's state before underground TE. Time recordings of seismic signals of the first four dynamic orthogonal collective variables, six various planes of phase portrait of four-dimensional phase space of orthogonal variables and the local Hurst exponent have been calculated for the dynamic analysis of states of systems I-IV. The analysis of statistical properties of seismic time series I-IV has been realized with the help of a set of discrete time-dependent functions (time correlation function and first three memory functions), their power spectra, and the first three points in the statistical spectrum of non-Markovity parameters. In all systems studied we have found a bizarre combination of the following spectral characteristics: the fractal frequency spectra adjustable by phenomena of usual and restricted self-organized criticality, spectra of white and color noises and unusual alternation of Markov and non-Markov effects of long-range memory

  19. Estimation of time-dependent Hurst exponents with variational smoothing and application to forecasting foreign exchange rates (United States)

    Garcin, Matthieu


    Hurst exponents depict the long memory of a time series. For human-dependent phenomena, as in finance, this feature may vary in the time. It justifies modelling dynamics by multifractional Brownian motions, which are consistent with time-dependent Hurst exponents. We improve the existing literature on estimating time-dependent Hurst exponents by proposing a smooth estimate obtained by variational calculus. This method is very general and not restricted to the sole Hurst framework. It is globally more accurate and easier than other existing non-parametric estimation techniques. Besides, in the field of Hurst exponents, it makes it possible to make forecasts based on the estimated multifractional Brownian motion. The application to high-frequency foreign exchange markets (GBP, CHF, SEK, USD, CAD, AUD, JPY, CNY and SGD, all against EUR) shows significantly good forecasts. When the Hurst exponent is higher than 0.5, what depicts a long-memory feature, the accuracy is higher.

  20. Extreme event distribution in Space Weather: Characterization of heavy tail distribution using Hurst exponents (United States)

    Setty, V.; Sharma, A.


    Characterization of extreme conditions of space weather is essential for potential mitigation strategies. The non-equilibrium nature of magnetosphere makes such efforts complicated and new techniques to understand its extreme event distribution are required. The heavy tail distribution in such systems can be a modeled using Stable distribution whose stability parameter is a measure of scaling in the cumulative distribution and is related to the Hurst exponent. This exponent can be readily measured in stationary time series using several techniques and detrended fluctuation analysis (DFA) is widely used in the presence of non-stationarities. However DFA has severe limitations in cases with non-linear and atypical trends. We propose a new technique that utilizes nonlinear dynamical predictions as a measure of trends and estimates the Hurst exponents. Furthermore, such a measure provides us with a new way to characterize predictability, as perfectly detrended data have no long term memory akin to Gaussian noise Ab initio calculation of weekly Hurst exponents using the auroral electrojet index AL over a span of few decades shows that these exponents are time varying and so is its fractal structure. Such time series data with time varying Hurst exponents are modeled well using multifractional Brownian motion and it is shown that DFA estimates a single time averaged value for Hurst exponent in such data. Our results show that using time varying Hurst exponent structure, we can (a) Estimate stability parameter, -a measure of scaling in heavy tails, (b) Define and identify epochs when the magnetosphere switches between regimes with and without extreme events, and, (c) Study the dependence of the Hurst exponents on the solar activity.

  1. The myriapodological legacy of Victor Ivanovich Motschoulsky (1810–1871) (United States)

    Golovatch, Sergei


    Abstract The little that remains of Motschoulsky’s myriapodological legacy in the collection of Moscow’s Zoological Museum proves to be of very limited value. Only one species of Diplopoda described by Motschoulsky, the Caucasian Hirudisoma roseum (Victor, 1839), is still in use, yet requiring a neotype designation, whereas the remaining few myriapod names he proposed are either nomina dubia or nomina nuda. The former include Scolopendra pentagramma Motschoulsky, 1866 (Chilopoda, Scolopendromorpha, Scolopendridae) and Strongylosoma carinulatum Motschoulsky, 1866 (Diplopoda, Polydesmida, Paradoxosomatidae), both from Japan, as well as Julus costulatus Motschoulsky, 1851 (Diplopoda, Callipodida, Schizopetalidae?), from Montenegro, because their type material is either inadequate or missing. PMID:25147455

  2. The myriapodological legacy of Victor Ivanovich Motschoulsky (1810-1871). (United States)

    Golovatch, Sergei


    The little that remains of Motschoulsky's myriapodological legacy in the collection of Moscow's Zoological Museum proves to be of very limited value. Only one species of Diplopoda described by Motschoulsky, the Caucasian Hirudisoma roseum (Victor, 1839), is still in use, yet requiring a neotype designation, whereas the remaining few myriapod names he proposed are either nomina dubia or nomina nuda. The former include Scolopendra pentagramma Motschoulsky, 1866 (Chilopoda, Scolopendromorpha, Scolopendridae) and Strongylosoma carinulatum Motschoulsky, 1866 (Diplopoda, Polydesmida, Paradoxosomatidae), both from Japan, as well as Julus costulatus Motschoulsky, 1851 (Diplopoda, Callipodida, Schizopetalidae?), from Montenegro, because their type material is either inadequate or missing.

  3. Representing Bodies. Victor Brauner’s Hybrids, Fragments and Mechanisms

    Directory of Open Access Journals (Sweden)

    Irina Cărăbaş


    emotional attachment. The French culture had been set long ago as a model for the entire Romanian modern culture and institutions. Consequently it is not surprising that poets and artists, including Victor Brauner, chosed to live and work in Paris in order to feel closer to what was considered to be the origin. Victor Brauner is discussed both in the context of the Romanian avant-garde and in the history of the French surrealism, but one cannot detect any tension between center and periphery. One motivation can be found in the myth he creates for himself. Meanwhile it is obvious that he wanted to identify himself with the French surrealism. Once settled in France he paid great attention to the theories and to the artists André Breton promoted. I will discuss the myth of the artist as well as the threads which connect Brauner to other artistic strategies bringing forth the body problem. Almost always his paintings and drawings display the ineluctable presence of a metamorphic body within no narrative construction. This preoccupation informed every stage of his career as he dedicated it the greatest energies of his artistic inventiveness. Before going into the subject, one needs to frame Brauner in a larger picture.

  4. Acerca de la existencia del fenómeno de Hurst.


    Poveda Jaramillo, Germán; Mesa Sánchez, Óscar José


    Se presenta una revisión de la paradoja conocida en hidrología como el fenómeno de Hurst. se presentan los distintos enfoques que se han planteado para tratar: un efecto pre-asintótico, no estacionariedad y memoria infinita en las series temporales de registros geofísicos. En este trabajo se plantea y se somete a prueba una hipótesis alterna: la estimación incorrecta del exponente de Hurst. Los diferentes estimadores que se han presentado en la literatura se evaluaron mediante un proceso no e...

  5. External neutron source anomalies analysis using Hurst's exponent for the Myrrha reactor

    Energy Technology Data Exchange (ETDEWEB)

    Henrice Junior, Edson; Goncalves, Alessandro C., E-mail: [Coordenacao dos Cursos de Pos-Graduacao em Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear; Palma, Daniel A.P., E-mail: [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeir, RJ (Brazil)


    Anomalous diffusion is usually marked by the non-linear growth of the variance in time, that is, the diffusion will be considered as anomalous if there is a deviation in the behaviour described before. This paper aims to identify anomalies in the neutron flux during the operation of an ADS (Accelerator Driven System) nuclear reactor as a result of a trip that originates in the proton accelerator as per project bases, from two different calculation methods for Hurst exponents. These methods are the R/S Method and the Detrended Fluctuation Analysis (DFA) Method. For that the Myrrha Reactor will be simulated using the SERPENT code and the neutron source will be subjected to a production peak at a given instant. The Hurst exponent has a direct application on determining the order of derivatives in fractional point-kinetics equations and the estimate for the fractional derivative can be related as being twice that of Hurst's exponent, according to the co-variance function in the Gauss' processes. After getting the Hurst's exponent a numerically solution is proposed. This subject being a theme very much in focus nowadays. (author)

  6. A series expansion of fractional Brownian motion with Hurst index exceeding 1/2

    NARCIS (Netherlands)

    K.O. Dzhaparidze (Kacha); J.H. van Zanten (Harry)


    textabstractLet $B$ be a fractional Brownian motion with Hurst index $H ge 1/2$. Denote by $x_1 < x_2 < cdots$ the positive, real zeros of the Bessel function $J_{-H$ of the first kind of order $-H$, and by $y_1 < y_2 < cdots$ the positive zeros of $J_{1-H$. We prove the series representation

  7. Fractional Black–Scholes option pricing, volatility calibration and implied Hurst exponents in South African context

    Directory of Open Access Journals (Sweden)

    Emlyn Flint


    Full Text Available Background: Contingent claims on underlying assets are typically priced under a framework that assumes, inter alia, that the log returns of the underlying asset are normally distributed. However, many researchers have shown that this assumption is violated in practice. Such violations include the statistical properties of heavy tails, volatility clustering, leptokurtosis and long memory. This paper considers the pricing of contingent claims when the underlying is assumed to display long memory, an issue that has heretofore not received much attention. Aim: We address several theoretical and practical issues in option pricing and implied volatility calibration in a fractional Black–Scholes market. We introduce a novel eight-parameter fractional Black–Scholes-inspired (FBSI model for the implied volatility surface, and consider in depth the issue of calibration. One of the main benefits of such a model is that it allows one to decompose implied volatility into an independent long-memory component – captured by an implied Hurst exponent – and a conditional implied volatility component. Such a decomposition has useful applications in the areas of derivatives trading, risk management, delta hedging and dynamic asset allocation. Setting: The proposed FBSI volatility model is calibrated to South African equity index options data as well as South African Rand/American Dollar currency options data. However, given the focus on the theoretical development of the model, the results in this paper are applicable across all financial markets. Methods: The FBSI model essentially combines a deterministic function form of the 1-year implied volatility skew with a separate deterministic function for the implied Hurst exponent, thus allowing one to model both observed implied volatility surfaces as well as decompose them into independent volatility and long-memory components respectively. Calibration of the model makes use of a quasi-explicit weighted

  8. Review: King, Victor T. (2008, The Sociology of Southeast Asia. Transformation in a Developing Region

    Directory of Open Access Journals (Sweden)

    Magnus C. M. Brod


    Full Text Available Review of the of the monograph: King, Victor T. (2008, The Sociology of Southeast Asia. Transformation in a Developing Region, Copenhagen: NIAS Press, ISBN 9788791114601, 352 pages.

  9. Silence and memory: christianity and the Constantinian dynasty in Aurelius Victor

    Directory of Open Access Journals (Sweden)

    Moisés Antiqueira


    Full Text Available This paper intend to present a new perspective on one of the most intriguing questions concerning the work Aurelius Victor wrote in the end of Constantius II’s reign: the silence about the Christian religion adopted by the reigning dynasty. By stressing some elements linked to paganism, Aurelius Victor asserted the relevance of a “pagan” social memory that would distinguish his narrative, therefore revealing an identitary dimension.

  10. Lamb's problem on random mass density fields with fractal and Hurst effects. (United States)

    Nishawala, V V; Ostoja-Starzewski, M; Leamy, M J; Porcu, E


    This paper reports on a generalization of Lamb's problem to a linear elastic, infinite half-space with random fields (RFs) of mass density, subject to a normal line load. Both, uncorrelated and correlated (with fractal and Hurst characteristics) RFs without any weak noise restrictions, are proposed. Cellular automata (CA) is used to simulate the wave propagation. CA is a local computational method which, for rectangular discretization of spatial domain, is equivalent to applying the finite difference method to the governing equations of classical elasticity. We first evaluate the response of CA to an uncorrelated mass density field, more commonly known as white-noise, of varying coarseness as compared to CA's node density. We then evaluate the response of CA to multiscale mass density RFs of Cauchy and Dagum type; these fields are unique in that they are able to model and decouple the field's fractal dimension and Hurst parameter. We focus on stochastic imperfection sensitivity; we determine to what extent the fractal or the Hurst parameter is a significant factor in altering the solution to the planar stochastic Lamb's problem by evaluating the coefficient of variation of the response when compared with the coefficient of variation of the RF.

  11. La pensée de Victor Frankl et notre temps


    Kühn, Rolf


    « La pensée de Victor Frankl et notre temps ». La pensée philosophique et logothérapeutique de V. E. Frankl est basée sur une phénoménologie de la liberté et du sentiment d’existence qui mettent en question les réductionnismes actuels du psychologisme, positivisme et nihi­lisme. L’individu réel répond à la vie à la fois axiologique et absolue pour donner un sens responsable à sa situation chaque fois unique. “Victor Frankl’s thought and our time”. Victor E. Frankl’s philosophical and logot...

  12. Classification of emotional states from electrocardiogram signals: a non-linear approach based on Hurst. (United States)

    Selvaraj, Jerritta; Murugappan, Murugappan; Wan, Khairunizam; Yaacob, Sazali


    Identifying the emotional state is helpful in applications involving patients with autism and other intellectual disabilities; computer-based training, human computer interaction etc. Electrocardiogram (ECG) signals, being an activity of the autonomous nervous system (ANS), reflect the underlying true emotional state of a person. However, the performance of various methods developed so far lacks accuracy, and more robust methods need to be developed to identify the emotional pattern associated with ECG signals. Emotional ECG data was obtained from sixty participants by inducing the six basic emotional states (happiness, sadness, fear, disgust, surprise and neutral) using audio-visual stimuli. The non-linear feature 'Hurst' was computed using Rescaled Range Statistics (RRS) and Finite Variance Scaling (FVS) methods. New Hurst features were proposed by combining the existing RRS and FVS methods with Higher Order Statistics (HOS). The features were then classified using four classifiers - Bayesian Classifier, Regression Tree, K- nearest neighbor and Fuzzy K-nearest neighbor. Seventy percent of the features were used for training and thirty percent for testing the algorithm. Analysis of Variance (ANOVA) conveyed that Hurst and the proposed features were statistically significant (p classification accuracy. The features obtained by combining FVS and HOS performed better with a maximum accuracy of 92.87% and 76.45% for classifying the six emotional states using random and subject independent validation respectively. The results indicate that the combination of non-linear analysis and HOS tend to capture the finer emotional changes that can be seen in healthy ECG data. This work can be further fine tuned to develop a real time system.

  13. Signal preserving and seismic random noise attenuation by Hurst exponent based time-frequency peak filtering (United States)

    Zhang, Chao; Li, Yue; Lin, Hongbo; Yang, Baojun


    Attenuating random noise is of great significance in seismic data processing. In recent years, time-frequency peak filtering (TFPF) has been successfully applied to seismic random noise attenuation field. However, a fixed window length (WL) is used in the conventional TFPF. Since a short WL in the TFPF is used to preserve signals while a long WL can eliminate random noise effectively, signal preserving and noise attenuation cannot be balanced by a fixed WL especially when the signal-to-noise ratio of the noisy seismic record is low. Thus, we need to divide a noisy signal into signal and noise segments before the filtering. Then a short WL is used to the signal segments to preserve signals and a long WL is chosen for noise segments to eliminate random noise. In this paper, we test the smoothness of signals and random noise in time using the Hurst exponent which is a statistic for representing smoothness characteristics of signals. The time-series of signals with higher smoothness which lead to larger Hurst exponent values, however random noise is a random series in time without fixed waveforms and thus its smoothness is low, so the signal and noise segments can be divided by the Hurst exponent values. After the segmentation, we can adopt different filtering WLs in the TFPF for different segments to make a trade-off between signal preserving and random noise attenuation. Synthetic and real data experiments demonstrate that the proposed method can remove random noise from seismic record and preserve reflection events effectively.

  14. Some comments on Hurst exponent and the long memory processes on capital markets (United States)

    Sánchez Granero, M. A.; Trinidad Segovia, J. E.; García Pérez, J.


    The analysis of long memory processes in capital markets has been one of the topics in finance, since the existence of the market memory could implicate the rejection of an efficient market hypothesis. The study of these processes in finance is realized through Hurst exponent and the most classical method applied is R/S analysis. In this paper we will discuss the efficiency of this methodology as well as some of its more important modifications to detect the long memory. We also propose the application of a classical geometrical method with short modifications and we compare both approaches.

  15. A novel method for detecting abrupt dynamic change based on the changing Hurst exponent of spatial images (United States)

    He, W.


    The climate system is a classical spatiotemporal evolutionary dynamic system with spatiotemporal correlation characteristics. Based on this, two-dimensional detrended fluctuation analysis (TD-DFA) is used to estimate the Hurst exponent of two-dimensional images. Then, we monitored the change of the Hurst exponent of the images to identify an abrupt dynamic change. We tested the performance of this method with a coupled spatiotemporal dynamic model and found that it works well. The changes in the Hurst exponents of the spatial images are stable when there is no dynamic change in the system, but there will be a clear non-stationary change of the Hurst exponents; for example, the abrupt mean values change if the dynamics of the system change. Thus, the TD-DFA method is suitable for detecting an abrupt dynamic change from natural and artificial images. The spatial images of the NCEP reanalysis of the daily average temperature exhibited fractality. Based on this, we found three non-stationary changes in the Hurst exponents for the NCEP reanalysis of the daily average temperature or for the annual average temperature in the region (60°S-60°N). It can be concluded that the climate system may have incurred three dynamic changes since 1961 on decadal timescales, i.e., in approximately the mid-1970s, the mid-1980s, and between the late 1990s and the early 2000s.

  16. Examination of the correlations between forest fires and solar activity using Hurst index

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    Radovanović Milan


    Full Text Available The aim of this paper is to find the functional dependence between the occurrence of forest fires and the factors inherent to solar activity. It has been shown that the amplitude of number of forest fires in the USA for warm period 2004-2007 is not time dependent. The method of seasonality indices for seasonal components filter was used for the decomposition of time series. In order to test this hypothesis the correlation analysis was held between the factors Hi and the number of fires taking into account time delay (lag between the onset of fires and solar activity. The results of this analysis show that any correlation coefficient is not higher than 0.2. For determination of the degree of randomness for time series of input and output parameters, the R/S analysis was conducted. The Hurst index was used for determining the depth of their memory. Based on the proximity of the Hurst index for the 10.7 cm solar flux categories and small forest fires, a reasonable assumption can be made that the dynamics of these time series is heavily dependent on the same factors. [Projekat Ministarstva nauke Republike Srbije, br. III47007

  17. Medieval Theories of Education: Hugh of St Victor and John of Salisbury (United States)

    FitzGerald, Brian D.


    This paper offers an assessment of two 12th-century theories of education, Hugh of St Victor's "Didascalicon" and John of Salisbury's "Metalogicon", maintaining that their works both draw on traditional Christian teachings and respond to contemporary pedagogical interests in systematising knowledge and integrating classical learning. The two works…

  18. 75 FR 36153 - Surety Companies Acceptable on Federal Bonds-Terminations: Victore Insurance Company (United States)


    ... Fiscal Service Surety Companies Acceptable on Federal Bonds--Terminations: Victore Insurance Company... the above-named company under 31 U.S.C. 9305 to qualify as acceptable surety on Federal bonds is... bonds currently in force with this company, bond-approving officers may let such bonds run to expiration...

  19. La parole manifestaire : lecture de la préface des orientales de Victor Hugo

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    Larissa Drigo Agostinho


    Full Text Available We intend here to read the preface of Victor Hugo’s Orientales after the contemporary criticism that establish the manifesto (and similar texts such as the preface as a literary genre, with particular language and other characteristics.

  20. Empire, Nationalism and the Jewish Question: Victor Adler and Otto Bauer

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    Wolfgang Maderthaner


    Full Text Available This paper uses the life and thought of two important figures in the history of Austrian socialism—Victor Adler and Otto Bauer—as a prism through which to examine the complex relationship between German nationalism, the Jewish Question and pro-Habsburgism among the early leadership of the Austrian Social Democratic Party.

  1. Stratégies de captation et de persuasion du sujet communicant Victor Hugo

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    Ida Lucia Machado


    Full Text Available Resumo: Este artigo propõe uma abordagem discursiva de um texto ficcional, mais especificamente, de um texto literário: trata-se do poema “Souvenir de la nuit du quatre” de Victor Hugo. Partindo desse enfoque, quisemos mostrar como foram elaboradas estratégias linguareiras que visam seduzir e persuadir o leitor; entre elas destacamos os diferentes papéis e a ironia amarga que está em sua base.Palavras-chave: Literatura francesa; Victor Hugo; Souvenir de la nuit du quatre; análise do discurso; persuasão; ironia.Résumé: Cet article propose une approche discursive d’un texte de fiction, plus spécifiquement, d’un texte littéraire: il s’agit du poème “Souvenir de la nuit du quatre” de Victor Hugo. Dans cette perspective, nous avons voulu montrer comment ont été mises en place des stratégies langagières visant la captation du lecteur, parmi elles, nous soulignons les différents rôles assumés par les voix qui “parlent” dans le poème et l’ironie amère qui s’en dégage.Mots-clés: Littérature française; Victor Hugo; Souvenir de la nuit du quatre; analyse du discours; persuasion; ironie.Keywords: French literature; Victor Hugo; Souvenir de la nuit du quatre; discourse analysis; persuasion; irony.

  2. Fractality Evidence and Long-Range Dependence on Capital Markets: a Hurst Exponent Evaluation (United States)

    Oprean, Camelia; Tănăsescu, Cristina


    Since the existence of market memory could implicate the rejection of the efficient market hypothesis, the aim of this paper is to find any evidence that selected emergent capital markets (eight European and BRIC markets, namely Hungary, Romania, Estonia, Czech Republic, Brazil, Russia, India and China) evince long-range dependence or the random walk hypothesis. In this paper, the Hurst exponent as calculated by R/S fractal analysis and Detrended Fluctuation Analysis is our measure of long-range dependence in the series. The results reinforce our previous findings and suggest that if stock returns present long-range dependence, the random walk hypothesis is not valid anymore and neither is the market efficiency hypothesis.

  3. An early prediction of 25th solar cycle using Hurst exponent (United States)

    Singh, A. K.; Bhargawa, Asheesh


    The analysis of long memory processes in solar activity, space weather and other geophysical phenomena has been a major issue even after the availability of enough data. We have examined the data of various solar parameters like sunspot numbers, 10.7 cm radio flux, solar magnetic field, proton flux and Alfven Mach number observed for the year 1976-2016. We have done the statistical test for persistence of solar activity based on the value of Hurst exponent (H) which is one of the most classical applied methods known as rescaled range analysis. We have discussed the efficiency of this methodology as well as prediction content for next solar cycle based on long term memory. In the present study, Hurst exponent analysis has been used to investigate the persistence of above mentioned (five) solar activity parameters and a simplex projection analysis has been used to predict the ascension time and the maximum number of counts for 25th solar cycle. For available dataset of the year 1976-2016, we have calculated H = 0.86 and 0.82 for sunspot number and 10.7 cm radio flux respectively. Further we have calculated maximum number of counts for sunspot numbers and F10.7 cm index as 102.8± 24.6 and 137.25± 8.9 respectively. Using the simplex projection analysis, we have forecasted that the solar cycle 25th would start in the year 2021 (January) and would last up to the year 2031 (September) with its maxima in June 2024.



    Husniyawati, Yeni Rahmah; Wulandari, Ratna Dwi


    The coverage of under-five children weighed at Posyandu represent the level of participation mothers in Posyandu activities. During three-year period, the coverage of under-five children weighed at Posyandu Puskesmas Sidotopo Wetan Surabaya City has not reached the target. It is also the responsibility of cadres. The object of this study was to to analyze the effect of motivation on the performance of health cadres based on Victor Vroom expectancy theory motivation in Posyandu Puskesmas Sidot...

  5. Victor Pelevin's Novel about Vampires as the form of Reflection on Postmodernism


    Anastasya L. Bobileva; Prokhorova, Tatyana G.; Olga V. Bogdanova


    The current stage of culture development is usually defined as post-postmodern. Although this term is not well established and is interpreted differently, in any case it involves the overcoming of postmodernism. In Russian literature we should mention Victor Pelevin among the authors, whose works demonstrate the post-postmodernist tendencies most clearly. The evolution of his prose testifies that the postmodern worldview and the very mechanism of postmodern writing has become the subject of c...

  6. Victor Vaughan (1851-1929) and the birth of bacteriology in the United States. (United States)

    Saadeh, Yamaan; Bartlett, Robert


    Victor Vaughan is well known for his numerous accomplishments and services to science, medicine, and public health. This paper discusses one of Dr Vaughan's earliest and most significant accomplishments: founding the Hygienic Laboratory at the University of Michigan in 1887, the first in the United States. The vision, initiative and planning demonstrated by this episode illustrate the characteristics that enabled Vaughan to have such an accomplished and storied career. © The Author(s) 2016.

  7. Influence of granulometry in the Hurst exponent of air liquid interfaces formed during capillary rising in a granular media

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    Gontijo Guilherme L.


    Full Text Available We report results concerning the fractal dimension of a air/fluid interface formed during the capillary rising of a fluid into a dense granular media. The system consists in a modified Hele-Shaw cell filled with grains at different granulometries and confined in a narrow gap between the glass plates. The system is then placed onto a water reservoir, and the liquid penetrates the medium due to capillary forces. We measure the Hurst exponent of the liquid/air interface with help of image processing, and follow the temporal evolution of the profiles. We observe that the Hurst exponent can be related with the granulometry, but the range of values are odd to the predicted values from models or theory.

  8. Generalized Hurst exponent estimates differentiate EEG signals of healthy and epileptic patients (United States)

    Lahmiri, Salim


    The aim of our current study is to check whether multifractal patterns of the electroencephalographic (EEG) signals of normal and epileptic patients are statistically similar or different. In this regard, the generalized Hurst exponent (GHE) method is used for robust estimation of the multifractals in each type of EEG signals, and three powerful statistical tests are performed to check existence of differences between estimated GHEs from healthy control subjects and epileptic patients. The obtained results show that multifractals exist in both types of EEG signals. Particularly, it was found that the degree of fractal is more pronounced in short variations of normal EEG signals than in short variations of EEG signals with seizure free intervals. In contrary, it is more pronounced in long variations of EEG signals with seizure free intervals than in normal EEG signals. Importantly, both parametric and nonparametric statistical tests show strong evidence that estimated GHEs of normal EEG signals are statistically and significantly different from those with seizure free intervals. Therefore, GHEs can be efficiently used to distinguish between healthy and patients suffering from epilepsy.

  9. Hurst exponent: A Brownian approach to characterize the nonlinear behavior of red blood cells deformability (United States)

    Mancilla Canales, M. A.; Leguto, A. J.; Riquelme, B. D.; León, P. Ponce de; Bortolato, S. A.; Korol, A. M.


    Ektacytometry techniques quantifies red blood cells (RBCs) deformability by measuring the elongation of suspended RBCs subjected to shear stress. Raw shear stress elongation plots are difficult to understand, thus most research papers apply data reduction methods characterizing the relationship between curve fitting. Our approach works with the naturally generated photometrically recorded time series of the diffraction pattern of several million of RBCs subjected to shear stress, and applies nonlinear quantifiers to study the fluctuations of these elongations. The development of new quantitative methods is crucial for restricting the subjectivity in the study of the cells behavior, mainly if they are capable of analyze at the same time biological and mechanical aspects of the cells in flowing conditions and compare their dynamics. A patented optical system called Erythrocyte Rheometer was used to evaluate viscoelastic properties of erythrocytes by Ektacytometry. To analyze cell dynamics we used the technique of Time Delay Coordinates, False Nearest Neighbors, the forecasting procedure proposed by Sugihara and May, and Hurst exponent. The results have expressive meaning on comparing healthy samples with parasite treated samples, suggesting that apparent noise associated with deterministic chaos can be used not only to distinguish but also to characterize biological and mechanical aspects of cells at the same time in flowing conditions.

  10. Asymptotic scaling properties and estimation of the generalized Hurst exponents in financial data (United States)

    Buonocore, R. J.; Aste, T.; Di Matteo, T.


    We propose a method to measure the Hurst exponents of financial time series. The scaling of the absolute moments against the aggregation horizon of real financial processes and of both uniscaling and multiscaling synthetic processes converges asymptotically towards linearity in log-log scale. In light of this we found appropriate a modification of the usual scaling equation via the introduction of a filter function. We devised a measurement procedure which takes into account the presence of the filter function without the need of directly estimating it. We verified that the method is unbiased within the errors by applying it to synthetic time series with known scaling properties. Finally we show an application to empirical financial time series where we fit the measured scaling exponents via a second or a fourth degree polynomial, which, because of theoretical constraints, have respectively only one and two degrees of freedom. We found that on our data set there is not clear preference between the second or fourth degree polynomial. Moreover the study of the filter functions of each time series shows common patterns of convergence depending on the momentum degree.

  11. Viktor IV. a jeho nástupci: církevní politika v době papežského schizmatu (1159-1180)


    Strnadová, Kristýna


    This thesis focuses on the politics of Antipope Victor IV and his successors Paschal III, Calixtus III and Innocent III, who were the opponents of Alexander III since the schismatic elections of 1159. The aim is to analyse the political thinking and actions of the antipopes, with an emphasis on the political relations of Victor IV. The thesis is divided into six thematic sections. The first deals with the pre-election developments and the election of 1159 itself. The second considers their po...


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    Arvi SEPP


    Full Text Available Victor Klemperers Tagebücher Ich will Zeugnis ablegen bis zum letzten: Tagebücher 1933-1945 haben nach ihrem Erscheinen Mitte der 1990er Jahre ein starkes Echo gefunden und gehören inzwischen zum Kanon der Tagebuchliteratur. Das zweibändige, während der nationalsozialistischen Diktatur entstandene Tagebuchwerk beschreibt die Lebenswelt eines deutsch-jüdischen Verfolgten im Dritten Reich. Der Antisemitismus zwang den Philologen zu einer Auseinandersetzung mit dem Relevanzverlust seiner Assimilationsbemühungen und seiner Kennzeichnung als Jude. Eine rekurrente Kompensationstaktik gegen seine erzwungene Randstellung besteht in der sprachkritischen Demontierung des Rassendenkens, um die Ungültigkeit des Antisemitismus nachzuweisen. Die Beobachtungen zur Lingua Tertii Imperii, die er in den Tagebuchblättern aufschrieb, wurden immer mehr zu seinem eigentlichen Werk. Das Tagebuch ist vor diesem Hintergrund in weiten Teilen zum Arbeitsjournal für die Sprachund Kulturanalysen Klemperers geworden. Der Interdependenz von Sprachkritik und Mentalitätsgeschichte in Klemperers Analyse der Sprache des Dritten Reiches gilt im vorliegenden Aufsatz das Hauptinteresse. Im ersten Teil wird der Frage nachgegangen, auf welche Art und Weise Victor Klemperer in seinen Notizen die Beziehung zwischen Sprache, Ideologie und Mentalität verstand. Im zweiten Teil wird unter Rückgriff auf Judith Butler und Louis Althusser in den Vordergrund gerückt, wie Victor Klemperer im Tagebuch vor Augen führt, dass das verletzende Sprechen gegen Juden im Nationalsozialismus eine subjektkonstituierende Wirkung hatte. Im letzten Teil des Aufsatzes gilt das Hauptaugenmerk der vom Tagebuchautor festgestellten diskursiven Einverleibung antisemitischer Rhetorik durch die verfolgte jüdische Bevölkerung.

  13. Desesperación y desesperanza: caducidad de las formas en Victor Shklovski

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    Fernando Bogado


    Full Text Available This article deals with the biographical works and chronicles written by Victor Shklovski, a remarkable figure in Russian formalism whose role as a writer was overshadowed by the reception of his theoretical work in academic circles. The “expressive” component in his style determines two types of “velocities”: these dialogue with one another, or oppose and complement each other in the texts studied, resulting therefore in a textuality that presents paradox, irony and literal meaning as main rhetoricaldevices when it comes to approaching a narrative which is very close to poetry

  14. Victor Kandinsky (1849-89): pioneer of modern Russian forensic psychiatry. (United States)

    Lerner, Vladimir; Margolin, Jacob; Witztum, Eliezer


    The paper describes Victor Kandinsky's professional achievements within nineteenth-century Russian forensic psychiatry. A thorough review of nineteenth-century Russian psychiatry is presented, followed by a short biographical account of Kandinsky's personal life. Within the backdrop of Russian forensic psychiatry toward the end of nineteenth century, Kandinsky's pioneer innovations in psychopathology and classification as well as his contributions to Russian forensic psychiatry are reviewed. These are exemplified by two of his forensic case studies relating to forensic responsibility and malingering, which are included in his famous book 'On Irresponsibility'.

  15. The myriapodological legacy of Victor Ivanovich Motschoulsky (1810–1871

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    Sergei Golovatch


    Full Text Available The little that remains of Motschoulsky’s myriapodological legacy in the collection of Moscow’s Zoological Museum proves to be of very limited value. Only one species of Diplopoda described by Motschoulsky, the Caucasian Hirudisoma roseum (Victor, 1839, is still in use, yet requiring a neotype designation, whereas the remaining few myriapod names he proposed are either nomina dubia or nomina nuda. The former include Scolopendra pentagramma Motschoulsky, 1866 (Chilopoda, Scolopendromorpha, Scolopendridae and Strongylosoma carinulatum Motschoulsky, 1866 (Diplopoda, Polydesmida, Paradoxosomatidae, both from Japan, as well as Julus costulatus Motschoulsky, 1851 (Diplopoda, Callipodida, Schizopetalidae?, from Montenegro, because their type material is either inadequate or missing.

  16. Hurst Exponent Analysis of Resting-State fMRI Signal Complexity across the Adult Lifespan

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    Jianxin Dong


    Full Text Available Exploring functional information among various brain regions across time enables understanding of healthy aging process and holds great promise for age-related brain disease diagnosis. This paper proposed a method to explore fractal complexity of the resting-state functional magnetic resonance imaging (rs-fMRI signal in the human brain across the adult lifespan using Hurst exponent (HE. We took advantage of the examined rs-fMRI data from 116 adults 19 to 85 years of age (44.3 ± 19.4 years, 49 females from NKI/Rockland sample. Region-wise and voxel-wise analyses were performed to investigate the effects of age, gender, and their interaction on complexity. In region-wise analysis, we found that the healthy aging is accompanied by a loss of complexity in frontal and parietal lobe and increased complexity in insula, limbic, and temporal lobe. Meanwhile, differences in HE between genders were found to be significant in parietal lobe (p = 0.04, corrected. However, there was no interaction between gender and age. In voxel-wise analysis, the significant complexity decrease with aging was found in frontal and parietal lobe, and complexity increase was found in insula, limbic lobe, occipital lobe, and temporal lobe with aging. Meanwhile, differences in HE between genders were found to be significant in frontal, parietal, and limbic lobe. Furthermore, we found age and sex interaction in right parahippocampal gyrus (p = 0.04, corrected. Our findings reveal HE variations of the rs-fMRI signal across the human adult lifespan and show that HE may serve as a new parameter to assess healthy aging process.

  17. The death of Sir Victor Horsley (1857-1916) and his burial in Amarah. (United States)

    Toodayan, Nadeem


    Sir Victor Alexander Haden Horsley (1857-1916), the pioneering British neurological surgeon, passed away 100 years ago. He died young in his sixtieth year from the effects of heat stroke while serving as consulting military surgeon to the Mediterranean Expeditionary Force in Amarah, modern-day Iraq, and was buried in the now largely abandoned "Amara War Cemetery." By the time of his death in 1916, Victor Horsley had established himself as one of the most eminent innovators of modern neurological surgery. His pioneering researches in cerebral physiology earned him an early reputation in the field, and his experiences with vivisection allowed him to confidently operate on the brain and spinal cord at a time when surgical intervention of the nervous system was fraught with uncertainty. Outside the operating theatre, Horsley was a proud advocate for a number of sometimes controversial sociopolitical issues; national temperance, women's suffrage, and medical unionism particularly interested him. He brought the same courageousness to the British army during the First World War, and labored tirelessly under considerable hardships to improve the conditions for soldiers. Otherwise robust and healthy, it was only through great self-denial and overwork that Horsley suddenly succumbed to the burning heat of Mesopotamia. He died as he lived-a fearless and painstaking fighter for the common man. His was a most beautiful life of unselfish devotion to others.

  18. a Comparison of Three Hurst Exponent Approaches to Predict Nascent Bubbles in S&P500 Stocks (United States)

    Fernández-Martínez, M.; Sánchez-Granero, M. A.; Muñoz Torrecillas, M. J.; McKelvey, Bill

    Since the pioneer contributions due to Vandewalle and Ausloos, the Hurst exponent has been applied by econophysicists as a useful indicator to deal with investment strategies when such a value is above or below 0.5, the Hurst exponent of a Brownian motion. In this paper, we hypothesize that the self-similarity exponent of financial time series provides a reliable indicator for herding behavior (HB) in the following sense: if there is HB, then the higher the price, the more the people will buy. This will generate persistence in the stocks which we shall measure by their self-similarity exponents. Along this work, we shall explore whether there is some connections between the self-similarity exponent of a stock (as a HB indicator) and the stock’s future performance under the assumption that the HB will last for some time. With this aim, three approaches to calculate the self-similarity exponent of a time series are compared in order to determine which performs best to identify the transition from random efficient market behavior to HB and hence, to detect the beginning of a bubble. Generalized Hurst Exponent, Detrended Fluctuation Analysis, and GM2 algorithms have been tested. Traditionally, researchers have focused on identifying the beginning of a crash. We study the beginning of the transition from efficient market behavior to a market bubble, instead. Our empirical results support that the higher (respectively the lower) the self-similarity index, the higher (respectively the lower) the mean of the price change, and hence, the better (respectively the worse) the performance of the corresponding stock. This would imply, as a consequence, that the transition process from random efficient market to HB has started. For experimentation purposes, S&P500 stock Index constituted our main data source.

  19. 75 FR 42445 - Yakov Kobel and Victor Berkovich v. Hapag-Lloyd America, Inc., Limco Logistics, Inc., and... (United States)


    ... From the Federal Register Online via the Government Publishing Office FEDERAL MARITIME COMMISSION Yakov Kobel and Victor Berkovich v. Hapag-Lloyd America, Inc., Limco Logistics, Inc., and International..., hereinafter ``Complainants,'' against Hapag-Lloyd America, Inc. (``Hapag-Lloyd''), Limco Logistics, Inc...

  20. Kuidas tudengid Lasnamäed väänasid / Victor Enrich, Sille Pihlak ; intervjueerinud Hendrik Alla

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    Enrich, Victor, 1967-


    Kunstiakadeemia arhitektuuriosakonna üliõpilased uurisid töötoas "Kuidas väänata maju ilma viga saamata", mida võiks ette võtta Lasnamäega. Intervjuu juhendajate, hispaania fotograafi Victor Enrichi ja arhitekt Sille Pihlakuga

  1. Spiritual Evolution as a Metamorphose (on the base of Victor Pelevin Novel "Life of Insects"

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    Tetyana Shevchuk


    Full Text Available The article deals with the aesthetic paradigm of the novel "Life of Insects" (1993, written by well-known Russian writer Victor Pelevin. Spiritual evolution or degradation of the heroes is represented by their metamorphosis from person to insect or vice versa. Actual questions of the novel are focused on the problems of spiritual vacuum, lost dignity, the meaning of life, the relationship to life as most rare and precious gift, the horror to live at the level of animal existence. The author models the reality, in which the insect mask captures the essence of the person. The focus is on the anthropocentric code of the novel, the evolutionary and regressive reasons, connected with the transmutations of the heroes.

  2. Interlocução entre Rudolf Otto, Carl Gustav Jung e Victor White

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    Rodrigo Pereira Ceccon


    Full Text Available In 1917 Rudolf Otto published the book The Sacred and proposing the recognition of the irrational aspect as the foundation and maintainer of religious expression by means of analogies and antonyms that the called the numinous. Later, at a conference in1937, Carl Gustav Jung uses the term numinous to clarify what he meant by religion, recognizing this as an observation on what grabs consciousness, thus extending the idea of the numinous to practice and clinical studies. Victor White, Jung's main collaborator in the field of theology, weaves a critical to Otto and Jung's position front to the understanding of religious phenomena, stating that it presents a unilateralism in recognition that only their irrational sphere supports religion. This article aims to lead to a theoretical discussion as to White's reflections on the idea of numinous, in contrast to the positions of Otto and Jung.

  3. La presencia del lector en la narrativa de Victor Hugo (1823-1834

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    Francisco Aiello


    Full Text Available The reader is very present in Victor Hugo’s novels published during the period 1823-1834 thanks to different textual strategies. So there is a rich dialogue between him and the author. Both of them are con-sidered in this article as textual construc-tions instead of empiric beings. The analysis shows that the relationship author-reader is clearly asymmetric as it is only the author who has got the control of the stories and its interpretation. That is why he decides to instruct the reader, whose reading skills are poor, by helping him to understand and by teaching him anything that could be neces-sary to appreciate the novel. However, this author proposes a familiar way of care to the reader inviting him to experience amusement through little enigmas or show-ing complicity.

  4. A French description of German psychology laboratories in 1893 by Victor Henri, a collaborator of Binet. (United States)

    Nicolas, Serge; Barnes, Marissa E; Murray, David J


    There is a rich tradition of writings about the foundation of psychology laboratories, particularly in the United States but also in France. Various documents exist concerning former German laboratories in American and French literature. But the most interesting French paper was certainly written by a young psychologist named Victor Henri (1872-1940) who was a close collaborator of Alfred Binet (1857-1911) in the 1890s. Visiting various psychology laboratories, he wrote, in 1893, a clear description of the laboratories of Wundt, G. E. Müller, Martius and Ebbinghaus. An English translation is given of Henri's paper and the historical importance of his contribution is here expounded by contrasting the German and French psychologies of the time.

  5. ‘To Serve and Protect’: The Ends of Harm by Victor Tadros

    DEFF Research Database (Denmark)

    Lippert-Rasmussen, Kasper


    In The Ends of Harm Victor Tadros develops an alternative to consequentialist, and non-consequentialist retributivist, accounts of the justifiability of punishment: the duty view. Crucial to this view is the claim that wrongdoers incur an enforceable duty to remedy their wrongs. They cannot undo...... to Tadros the ‘means principle’ that we should not harm others as a means, properly construed, does not apply to cases where the victim has an enforceable duty to bear the kind of harm that he or she is being made to suffer. In this article, I shall express reservations about Tadros’ defense...... and interpretation of the means principle. In presenting his position, Tadros also sets out some interesting anti-retributivist considerations casting doubt on the idea that wrongdoers’ suffering is non-instrumentally good. I shall challenge these. Finally, I shall suggest that the duty view may have...

  6. Victor Shnirelman, The myth of the Khazars and intellectual antisemitism in Russia, 1970s-1990s


    Laruelle, Marlène


    Le livre de Victor Shnirelman apporte une contribution originale à l’histoire de l’antisémitisme russe moderne en en retraçant la présence au sein de discours intellectuels. Avant comme après 1991, un certain antisémitisme s’affirmant comme « scientifique » s’exprime autour du thème des Khazars : ces derniers, probablement d’origine turcique, constituent l’un des seuls exemples de conversion au judaïsme de populations non sémitiques. Ils ont joué un rôle majeur dans l’histoire ancienne de la ...

  7. Victor Legley: some notes on his thoughts and Cathédrale d’acier

    Directory of Open Access Journals (Sweden)

    de Roeck, Ronald


    Full Text Available The article proposes to extend the knowledge of the figure and work of Victor Legley. It offers some notes about his life, studies and professional activities. It informs about his activities as a musical philosopher, and makes some of his thoughts known about contemporary composition, music’s social function, the composer’s role, and the relations between composer, interpreter, critic and management, today. The major part of the article is dedicated to his compositions. La Cathédrale d’acier, opus 52, from 1958, has been chosen for an analytical research on his intense thematic work, typical for his production, and also to establish the general characteristics of this composition, representative of much of his work. Finally, we present some conclusions on the importance of his ideas and his production as a composerEl artículo propone ampliar el conocimiento de la figura y obra de Victor Legley. Empieza con unos apuntes sobre su vida, sus estudios y actividades profesionales. Destaca sus actividades como pensador de la música, y da a conocer algunas de sus ideas sobre la composición contemporánea, la función social de la música, el papel del compositor, el nivel estético en nuestros días. Buena parte del artículo se centra en su producción compositiva. Se ha escogido La Cathédrale d’acier, opus 52, de 1958, para hacer una investigación analítica del intenso trabajo temático, que es propio de su obra, y para establecer la características generales de esta composición, representativa de buena parte de su obra. Finalmente, se presentan unas conclusiones sobre la importancia de las ideas y la producción compositiva de Legley.

  8. A Different Statistic for the Management of Portfolios - the Hurst Exponent: Persistent, Antipersistent or Random Time Series?

    Directory of Open Access Journals (Sweden)



    Full Text Available In recent years, research in the capital markets and management of portfolios has been producing more questions than it has been answering: the need for a new paradigm or a new way of looking at things has become more and more concludent. The existing and classical view of capital markets, based on efficient market hypothesis, has a definite theory for the last six decades, but it is still not capable of significantly increase the understanding of how capital markets function. The purpose of this article is to theoretically describe a less used statistic coefficient, having a vast area of applicability due to its robustness, and which can easily divide the random series from a non-random series, even if the random series is non-Gaussian: the Hurst exponent.

  9. From victim to victor: "breaking bad" and the dark potential of the terminally empowered. (United States)

    Lewis, Mark A


    As treatments for malignancies have improved incrementally over the preceding decades, patients with cancer have been encouraged to reject an attitude of hopelessness and to choose instead the role of fighters. The recasting of the cancer patient as warrior and winner, upheld through the Livestrong movement, reaches its monstrous apotheosis in the form of Walter White, the central figure in the AMC television series "Breaking Bad." The story begins with Walt as the protagonist, but the arc of this conversion narrative transforms him into the antagonist, exploring the darkest potential of his post-diagnosis empowerment. His awareness of his own mortality enables him to take risks that his more rational, pre-cancer self would have avoided. Rather than being rendered impotent by fear of an impending death, he finds himself emboldened, liberated from behavioral norms, capable of heretofore-unthinkable violence and even murder. As Walt moves from victim to victor, the viewer realizes the perils of a survive-at-all-costs mentality and is forced to question their own, initially sympathetic perception of Walt. The series subverts the notion of the cancer patient made noble through struggle by portraying a man betrayed by his own body who then becomes willing to betray everything else in the amoral service of his pride.

  10. Hurst exponent used as a tool to differentiate between magmatic and fluid-induced processes as reflected in crystal geochemistry (United States)

    Domonik, A.; Słaby, E.; Śmigielski, M.


    A self-similarity parameter, the Hurst exponent (H) (called also roughness exponent) has been used to show the long-range dependence of element behaviour during the processes. The H value ranges between 0 and 1; a value of 0.5 indicates a random distribution indistinguishable from noise. For values greater or less than 0.5, the system shows non-linear dynamics. H 0.5 corresponds to increasing persistence (less chaotic). Such persistence is characterized as an effect of a long-term memory, and thus by a large degree of positive correlation. In theory, the preceding data constantly affect the next in the whole temporal series. Applied to chaotic dynamics, the system shows a subtle sensitivity to initial conditions. The process can show some degree of chaos, due to local variations, but generally, the trend preserves its persistent character through time. If the exponent value is low, the process shows frequent and sudden reversals e.g. the trends of such a process show mutual negative correlation of the succeding values in the data series. Thus, the system can be described as having a high degree of deterministic chaos. Alkali feldspar megacrysts grown from mixed magmas and recrystallized due to interaction with fluids have been selected for the study (Słaby et al., 2011). Hurst exponent variability has been calculated within some primary-magmatic and secondary-recrystallized crystal domains for some elements redistributed by crystal fluid interaction. Based on the Hurst exponent value two different processes can easily be recognized. In the core of the megacrysts the element distribution can be ascribed to magmatic growth. By contrast, the marginal zones can relate to inferred late crystal-fluid interactions. Both processes are deterministic, not random. The spatial distribution of elements in the crystal margins is irregular, with high-H values identifying the process as persistent. The trace element distributions in feldspar cores are almost homogeneous and only

  11. Victor Pelevin's Novel about Vampires as the form of Reflection on Postmodernism

    Directory of Open Access Journals (Sweden)

    Anastasya L. Bobileva


    Full Text Available The current stage of culture development is usually defined as post-postmodern. Although this term is not well established and is interpreted differently, in any case it involves the overcoming of postmodernism. In Russian literature we should mention Victor Pelevin among the authors, whose works demonstrate the post-postmodernist tendencies most clearly. The evolution of his prose testifies that the postmodern worldview and the very mechanism of postmodern writing has become the subject of critical reflection in the late works of the writer. The novel by V. Pelevin "Empire V" (2006 is the material of the analysis in the article. The aim of the study is to reveal the nature and the forms of postmodernism reflection manifested in this work. During the analysis the authors established that Pelevin plays with a popular genre of mass culture - a novel about vampires, using it as a kind of metaphorical way to clarify the nature of postmodern literature, which appropriates, absorbs and exploits the forms, ideas and motives earlier developed in culture. Postmodernists, like vampires, borrow information from different sources and use "someone else's blood" for their own purposes. Combining the "languages" of mass and elite cultures, activating the intertextual links, Pelevin eventually pursues antipostomodernist goals: he reveals the totality of the simulativity, proves that mass culture is ready to absorb postmodernism, and turn it into an empty signifier. This can be defined as a kind of cultural reflection, as a form of the self-reflection and writer’s cognition on the state of modern culture.

  12. Victor and Erika Webnovela: An Innovative Generation @ Audience Engagement Strategy for Prevention. (United States)

    Andrade, Elizabeth L; Evans, W Douglas; Edberg, Marc C; Cleary, Sean D; Villalba, Ricardo; Batista, Idalina Cubilla


    Entertainment-education (E-E) approaches for young audiences continue to evolve in order to keep stride with younger generations' affinity for technology. E-E and novelas have been used with a wide variety of audiences in the United States, in particular hard-to-reach Latino populations, and have demonstrated effectiveness in disseminating culturally relevant prevention information for a wide variety of health-related risk factors and behaviors. This study discusses the formative research and active engagement of Latino youth living in Langley Park, Maryland, for the development and filming of an innovative 6-episode webnovela titled Victor and Erika (V&E). V&E is part of a larger branding strategy of the Adelante Positive Youth Development intervention that seeks to prevent substance abuse, sexual risk, and interpersonal violence among Latino youth; V&E is also an intervention component. The V&E webnovela is a dramatic portrayal of the lives of 2 immigrant Latino teenagers that also disseminates risk prevention messages. The storyline represents the turning the corner (to a better life) theme that underlies the Adelante intervention brand. Formative research was conducted for character development (n = 20) and creative development of the episodes (n = 14). Results of the formative research showed that youth recommended inclusion of the following topics in V&E episodes: sex, unintended pregnancy, fidelity, trust, family dynamics, immigration status, violence, school dropout, respect, home life, and poverty. Detailed character and episode descriptions are provided, and the implications of using the V&E series as a tool for in-person and online engagement of youth and the dissemination of prevention messages are also discussed.


    Directory of Open Access Journals (Sweden)

    Leonardo Plazas Nossa


    Full Text Available El objetivo de este trabajo es estimar el exponente o parámetro de Hurst y la dimensión fractal para el análisis de series de tiempo de espectrometría UV-Vis, utilizando el análisis de componentes principales PCA (Principal Component Analysis. El análisis se realiza para comprender si las series de tiempo de absorbancia UV-Vis son persistentes, anti-persistentes, determinísticas o si son ruido blanco. Se utilizaron tres diferentes series de tiempo de absorbancia UV-Vis para tres diferentes sitios de estudio: (i Planta de tratamiento de aguas residuales Salitre (PTAR en Bogotá; (ii Estación elevadora de Gibraltar en Bogotá (EEG; y (iii Planta de tratamiento de aguas residuales San Fernando (PTAR en Itagüí (sur de Medellín. Cada una de las series de tiempo tiene igual número de muestras (5705. Se redujo la dimensionalidad de los espectros de absorbancia, dada su alta correlación, con PCA y se utilizó para cada sitio de estudio la primera componente principal. Esta componente principal explicó entre el 82% al 94% de la variabilidad para los tres sitios de estudio. Se determinaron los exponentes de Hurst: (i 0.8 para PTAR Salitre; (ii 0.85 para EEG; y (iii 0.89 para PTAR San Fernando. A partir de los valores de los exponentes de Hurst se determinan las dimensiones fractales para las tres series de tiempo de absorbancia UV-Vis en los tres sitios de estudio y se obtiene en promedio una dimensión fractal de 1153. Las tres series de tiempo de absorbancia UV-Vis son persistentes y con alta auto-similitud, dado que el exponente de Hurst es mayor a 0.5.

  14. Generalized Hurst exponent and multifractal function of original and translated texts mapped into frequency and length time series (United States)

    Ausloos, M.


    A nonlinear dynamics approach can be used in order to quantify complexity in written texts. As a first step, a one-dimensional system is examined: two written texts by one author (Lewis Carroll) are considered, together with one translation into an artificial language (i.e., Esperanto) are mapped into time series. Their corresponding shuffled versions are used for obtaining a baseline. Two different one-dimensional time series are used here: one based on word lengths (LTS), the other on word frequencies (FTS). It is shown that the generalized Hurst exponent h(q) and the derived f(α) curves of the original and translated texts show marked differences. The original texts are far from giving a parabolic f(α) function, in contrast to the shuffled texts. Moreover, the Esperanto text has more extreme values. This suggests cascade model-like, with multiscale time-asymmetric features as finally written texts. A discussion of the difference and complementarity of mapping into a LTS or FTS is presented. The FTS f(α) curves are more opened than the LTS ones.

  15. Review Article: On the relation between the seismic activity and the Hurst exponent of the geomagnetic field at the time of the 2000 Izu swarm

    Directory of Open Access Journals (Sweden)

    F. Masci


    Full Text Available Many papers document the observation of earthquake-related precursory signatures in geomagnetic field data. However, the significance of these findings is ambiguous because the authors did not adequately take into account that these signals could have been generated by other sources, and the seismogenic origin of these signals have not been validated by comparison with independent datasets. Thus, they are not reliable examples of magnetic disturbances induced by the seismic activity. Hayakawa et al. (2004 claim that at the time of the 2000 Izu swarm the Hurst exponent of the Ultra-Low-Frequency (ULF: 0.001–10 Hz band of the geomagnetic field varied in accord with the energy released by the seismicity. The present paper demonstrates that the behaviour of the Hurst exponent was insufficiently investigated and also misinterpreted by the authors. We clearly show that during the Izu swarm the changes of the Hurst exponent were strongly related to the level of global geomagnetic activity and not to the increase of the local seismic activity.

  16. [Victor Khrisanfovich Kandinsky (1849-1889) : Contributions of a Russian psychiatrist to the concepts of pseudohallucination and schizophrenias]. (United States)

    Engmann, B; Steinberg, H


    The article highlights the important work of the Russian psychiatrist Victor Khrisanfovich Kandinsky. His merits, in particular those in the fields of hallucinations and schizophrenias, have hitherto been neglected despite the fact that several of his articles have been published in German medical journals. He defined the term pseudohallucination in a way which is still common today. For him the criterion which separates it from real hallucinations was that the patient is aware of the fallacy of the phenomena perceived. Furthermore, his concept of ideophrenia can be regarded as a one of the precursors to today's concept of schizophrenias.

  17. Asteroids IV (United States)

    Michel, Patrick; DeMeo, Francesca E.; Bottke, William F.

    . Asteroids, like planets, are driven by a great variety of both dynamical and physical mechanisms. In fact, images sent back by space missions show a collection of small worlds whose characteristics seem designed to overthrow our preconceived notions. Given their wide range of sizes and surface compositions, it is clear that many formed in very different places and at different times within the solar nebula. These characteristics make them an exciting challenge for researchers who crave complex problems. The return of samples from these bodies may ultimately be needed to provide us with solutions. In the book Asteroids IV, the editors and authors have taken major strides in the long journey toward a much deeper understanding of our fascinating planetary ancestors. This book reviews major advances in 43 chapters that have been written and reviewed by a team of more than 200 international authorities in asteroids. It is aimed to be as comprehensive as possible while also remaining accessible to students and researchers who are interested in learning about these small but nonetheless important worlds. We hope this volume will serve as a leading reference on the topic of asteroids for the decade to come. We are deeply indebted to the many authors and referees for their tremendous efforts in helping us create Asteroids IV. We also thank the members of the Asteroids IV scientific organizing committee for helping us shape the structure and content of the book. The conference associated with the book, "Asteroids Comets Meteors 2014" held June 30-July 4, 2014, in Helsinki, Finland, did an outstanding job of demonstrating how much progress we have made in the field over the last decade. We are extremely grateful to our host Karri Muinonnen and his team. The editors are also grateful to the Asteroids IV production staff, namely Renée Dotson and her colleagues at the Lunar and Planetary Institute, for their efforts, their invaluable assistance, and their enthusiasm; they made life as

  18. Fast, global, and entrepreneurial: supply chain management, Hong Kong style. An interview with Victor Fung. Interview by Joan Magretta. (United States)

    Fung, V


    Li & Fung, Hong Kong's largest export trading company, has been an innovator in supply chain management--a topic of increasing importance to many senior executives. In this interview, chairman Victor Fung explains both the philosophy behind supply chain management and the specific practices that Li & Fung has developed to reduce costs and lead times, allowing its customers to buy "closer to the market." Li & Fung has been a pioneer in "dispersed manufacturing." It performs the higher-value-added tasks such as design and quality control in Hong Kong, and outsources the lower-value-added tasks to the best possible locations around the world. The result is something new: a truly global product. To produce a garment, for example, the company might purchase yarn from Korea that will be woven and dyed in Taiwan, then shipped to Thailand for final assembly, where it will be matched with zippers from a Japanese company. For every order, the goal is to customize the value chain to meet the customer's specific needs. To be run effectively, Victor Fung maintains, trading companies have to be small and entrepreneurial. He describes the organizational approaches that keep the company that way despite its growing size and geographic scope: its organization around small, customer-focused units; its incentives and compensation structure; and its use of venture capital as a vehicle for business development. As Asia's economic crisis continues, chairman Fung sees a new model of companies emerging--companies that are, like Li & Fung, narrowly focused and professionally managed.

  19. Preliminary report on Echinoidea and Asteroidea (Echinodermata of the Joint Chilean-German-Italian Magellan Victor Hensen Campaign, 17 October - 25 November 1994

    Directory of Open Access Journals (Sweden)

    Alberto Larraín


    Full Text Available Part of the echinoderm material (Echinoidea and Asteroidea sampled by 59 Agassiz trawls during the Victor Hensen Campaign 1994 is summarized in a preliminary species list. In total, 7 echinoids and 21 asteroids have been determined to species from the area between Paso Ancho and Cape Horn. All of them were known from the area before.

  20. Oceanographic profile temperature, salinity, and oxygen measurements collected using bottle from the VICTOR BUGAEV, PASSAT and other platforms in the North Atlantic and Mediterranean Sea from 1981 to 1990 (NODC Accession 0000556) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Physical, chemical, and other data were collected in the North Atlantic Ocean and Mediterranean Sea from the VICTOR BUGAEV and other platforms from 03 October 1981...

  1. [Prevalence of entero-parasitosis in one Andean community in the Province of Victor Fajardo, Ayacucho, Peru]. (United States)

    Cabrera, Milagros; Verástegui, Manuela; Cabrera, Rufino


    The objectives of the study were to find out the prevalence and distribution of entero-parasitism and determine the prevalence of coproantigens of Taenia solium in the Andean community of Huancapi, Province of Victor Fajardo, Ayacucho, Peru. In the observational, transversal-descriptive study carried out between July and September 2000, by the Ritchie and Ziehl-Neelsen methods, modified by Cryptosporidium sp., samples of feces from 312 persons of the general population were examined. In addition, the presence of coproantigens of T. solium was investigated by the ELISA method. 77.88% (243) were positive to one or more entero-parasites. The prevalence for each protozoan specie is: 66.99% for Entamoeba coli; 12,50% for Iodamoeba butschlii; 10.90% for Chilomastix mesnili and 10.57% for Giardia lamblia; for the helminthes it was: 4.49% for Ascaris lumbricoides; 3.52% for Hymenolepis nana and 1.28% for Trichuris trichiura. Coproantigens of T. solium were detected in 3.52% of the samples. The prevailing commensal protozoan indicate that there are deficiencies in the basic sanitary services, particularly in water for domestic consumption. Huancapi is a new endemic zone for infection by T. solium.

  2. Lessons Learned From a Randomized Study of Oral Valganciclovir Versus Parenteral Ganciclovir Treatment of Cytomegalovirus Disease in Solid Organ Transplant Recipients: The VICTOR Trial. (United States)

    Åsberg, Anders; Humar, Atul; Rollag, Halvor; Jardine, Alan G; Kumar, Deepali; Aukrust, Pål; Ueland, Thor; Bignamini, Angelo A; Hartmann, Anders


    The VICTOR study showed comparable efficacy of treatment with intravenous ganciclovir and oral valganciclovir for cytomegalovirus (CMV) disease in solid organ transplant recipients. Oral therapy is now recommended treatment in clinical practice and guidelines. The VICTOR biobank was used in a series of post hoc analyses that yielded unique and clinically valuable insights into CMV treatment and pathogenesis. For example, the importance of tailoring therapy to initial viral load, the effect of immunosuppression on outcomes, and the need to continue therapy until undetectable viral load to prevent recurrence and emergence of resistant strains. Data were also used to validate the use of international units (IU) in quantitative measurements of CMV DNAemia, which may help future studies to define relevant cutoffs for treatment guidance. The analyses also showed the importance of inflammation on viral outcomes and identified potential targets for future studies. Here we summarize the valuable lessons learned from analysis of the VICTOR data set and sample repository. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail

  3. Victor Assis Brasil: a importância do período na Berklee School of Music (1969-1974 em seu estilo composicional Victor Assis Brasil: the importance of the Berklee School of Music period (1969-1974 on his compositional style

    Directory of Open Access Journals (Sweden)

    Marco Túlio de Paula Pinto


    Full Text Available Discussão sobre o papel do ambiente musical de Boston, especialmente da Berklee School of Music entre 1969 e 1974, no desenvolvimento do estilo composicional e das habilidades como arranjador de Victor Assis Brasil (1945-1981 e seus reflexos na parcela de sua produção musical que apresenta a mistura de elementos de música clássica, jazz e música brasileira.Discussion about the influence of the musical environment of Boston, especially that of the Berklee School of Music, between 1969 and 1974, on the development of the compositional style and arranging skills of Brazilian saxophone player and composer Victor Assis Brasil. (1945-1981, and its reflexes in his musical production which mixes elements from classical music, jazz and Brazilian popular music.

  4. Marcel Duchamp, Constantin Brancusi, Victor Brauner : leurs rencontres et les retombées sur leurs œuvres

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    Cristian-Robert Velescu


    Full Text Available Duchamp avait rencontré Brancusi en 1912, année qui marque le début d’une amitié consignée par l’histoire de l’art. Son parcours avait été fixé dans les pages de leur correspondance, conservées au Centre Georges Pompidou. Le lecteur est surpris de constater qu’il n’y a que des faits anodins qui soient consignés, tandis que les références aux conceptions artistiques sont presque totalement absentes. Toutefois, en lisant les témoignages de Duchamp conservés dans les célèbres Boîtes (verte et blanche, on se rend compte qu’il partage les conceptions platoniciennes de son ami sculpteur, chose importante, qui nous laisse formuler des suppositions concernant une influence dirigée de Brancusi dans la direction Duchamp. À son tour, durant l’intervalle 1925–1928, Victor Brauner était l’hôte de Brancusi dans l’atelier de l’impasse Ronsin. C’est ici qu’il a pu rencontrer Duchamp, qui s’y rendait fréquemment dans les années 20. Une rencontre qui a certainement eu des retombées sur l’oeuvre du futur peintre surréaliste. La preuve en est dans deux de ses toiles, Tête et deux boxeurs et Passivité courtoise. Faut-il s’étonner que le message que Duchamp avait mis dans les structures sémantiques de son chef-d’oeuvre La Mariée mise à nu par ses célibataires, même ou Le Grand Verre y avait été « logé » d’une manière évidente ? Mais alors on doit reconnaître que lors de leurs rencontres de chez Brancusi, Duchamp avait transmis à Brauner des informations très précises sur l’iconographie du Grand Verre, ainsi que sur la quatrième dimension, que le futur peintre surréaliste allait reconvertir dans les trois dimensions de l’espace ordinaire. Perçu dans cette perspective, l’atelier de l’impasse Ronsin nous semble un lieu où les idées des trois artistes ont pu communiquer d’une manière osmotique.

  5. Victor Olufolahan.Lasebikan

    African Journals Online (AJOL)

    Please show in the respondent card the place that best describes where you smoked. (Motor park, bar, a .... or socio-economic disparities such as the age of their vehicle (Assailly & Biecheler as cited in. Laumon et al ..... the National Road Transport Workers Union. I thank the latter's coordinating staff both for theirassistance ...


    DEFF Research Database (Denmark)

    Isar, Nicoletta

    , quality printed in Europe. Marketing and distribution through large book wholesalers and ecommerce channels in US bookstores and eCommerce internationally including Barnes and Noble, Borders, Amazon in USA, Amazon Canada, Amazon France, Amazon Germany, Amazon UK, Amazon Australia and others. The book...... is created by Petru A. RUSSU, editor and publisher of World of Art (WOA), fine artist (lives and works in London and Stockholm)....

  7. Proneness to social anxiety modulates neural complexity in the absence of exposure: A resting state fMRI study using Hurst exponent. (United States)

    Gentili, Claudio; Vanello, Nicola; Cristea, Ioana; David, Daniel; Ricciardi, Emiliano; Pietrini, Pietro


    To test the hypothesis that brain activity is modulated by trait social anxiety, we measured the Hurst Exponent (HE), an index of complexity in time series, in healthy individuals at rest in the absence of any social trigger. Functional magnetic resonance imaging (fMRI) time series were recorded in 36 subjects at rest. All volunteers were healthy without any psychiatric, medical or neurological disorder. Subjects completed the Liebowitz Social Anxiety Scale (LSAS) and the Brief Fear of Negative Evaluation (BFNE) to assess social anxiety and thoughts in social contexts. We also obtained the fractional Amplitude of Low Frequency Fluctuations (fALFF) of the BOLD signal as an independent control measure for HE data. BFNE scores correlated positively with HE in the posterior cingulate/precuneus, while LSAS scores correlated positively with HE in the precuneus, in the inferior parietal sulci and in the parahippocamus. Results from fALFF were highly consistent with those obtained using LSAS and BFNE to predict HE. Overall our data indicate that spontaneous brain activity is influenced by the degree of social anxiety, on a continuum and in the absence of social stimuli. These findings suggest that social anxiety is a trait characteristic that shapes brain activity and predisposes to different reactions in social contexts. Copyright © 2015. Published by Elsevier Ireland Ltd.

  8. NNDSS - Table IV. Tuberculosis (United States)

    U.S. Department of Health & Human Services — NNDSS - Table IV. Tuberculosis - 2014.This Table includes total number of cases reported in the United States, by region and by states, in accordance with the...

  9. NNDSS - Table IV. Tuberculosis (United States)

    U.S. Department of Health & Human Services — NNDSS - Table IV. Tuberculosis - 2015.This Table includes total number of cases reported in the United States, by region and by states, in accordance with the...

  10. NNDSS - Table IV. Tuberculosis (United States)

    U.S. Department of Health & Human Services — NNDSS - Table IV. Tuberculosis - 2016.This Table includes total number of cases reported in the United States, by region and by states, in accordance with the...

  11. IV access in dental practice.

    LENUS (Irish Health Repository)

    Fitzpatrick, J J


    Intravenous (IV) access is a valuable skill for dental practitioners in emergency situations and in IV sedation. However, many people feel some apprehension about performing this procedure. This article explains the basic principles behind IV access, and the relevant anatomy and physiology, as well as giving a step-by-step guide to placing an IV cannula.

  12. Dibromidodimethyldipyridineplatinum(IV

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    Mairéad E. Kelly


    Full Text Available In the title complex, [PtBr2(CH32(C5H5N2], the PtIV metal centre lies on a twofold rotation axis and adopts a slightly distorted octahedral coordination geometry. The structure displays weak intramolecular C—H...Br hydrogen-bonding interactions.

  13. Haïti : les pouvoirs de l'art dans Le Sang et la Mer de Gary Victor et La Belle Amour humaine de Lyonel Trouillot

    Directory of Open Access Journals (Sweden)

    Odile Gannier


    Full Text Available Dans cet article, l'auteure pose une question en écho aux événements de janvier 2010 : "comment écrire encore après les catastrophes ?". Elle en prend pour témoins les œuvres de Gary Victor et de Lyonel Trouillot (respectivement parues en 2010 et 2011 qui, pour l'une, raconte l'histoire d'une orpheline, Hérodiane, au parcours difficile, et rapporte, pour l'autre, l'enquête d'Anaïse, une étrangère, sur les traces de sa famille haïtienne. Odile Gannier analyse la construction de l'intrigue et des personnages, mais aussi les tonalités et les genres représentés dans les deux œuvres, ainsi que leurs multiples similitudes avec d'autres formes de production artistique (la peinture en particulier.

  14. A prática espiritual de Jesus e o sentido da vida: o sentido da vida no cristianismo analisado a partir da teoria de VICTOR EMIL FRANKL


    Tagliaferro, Edson Adélio


    A proposta deste nosso trabalho é fazer uma análise de um dos mais profundos questionamentos da humanidade que é a pergunta sobre o sentido da vida. Com respeito a esta questão, encontramos posições tanto contrárias como favoráveis à possibilidade de que a vida tenha um sentido e, desta forma, há pessoas que julgam não ser possível encontrá-lo, e há os que julgam que sem encontrá-lo caímos no vazio existencial, onde as neuroses são geradas. Entre estes encontrase Victor Emil Fr...

  15. O acontecimento Victor de Aveyron: esboço de uma genealogia da psiquiatrização da infância

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    Lilia Ferreira Lobo


    Full Text Available O que aqui se denomina como “acontecimento Victor de Aveyron” inaugura, no contexto das práticas do século XVIII, novas questões para os saberes e as práticas médicas e pedagógicas, e novos problemas para este estranho objeto de conhecimento: “homem”.Este texto pretende traçar, a partir dos relatórios de Jean Marc Itard, sobre a tarefa que desenvolve na tentativa de educar o menino selvagem encontrado nos bosques de Aveyron, um esboço de uma genealogia histórica, segundo a perspectiva do pensamento de Michel Foucault. Trata-se do processo de construção da aliança médico-pedagógica e seus dispositivos de poder disciplinar e de normalização que deram origem à expansão da psiquiatria, processo que não passou pela criança louca, mas pela criança idiota. Se o aparecimento de Victor para as luzes da civilização provocou a produção de um saber colonizador sobre o corpo resistente à normalização, a busca do limite do corpo selvagem, tão incapaz quanto o idiota, provocou também o surgimento do dispositivo da aliança médico-pedagógica que até hoje observamos incidir sobre os corpos infantis, mesmo considerando as diferenças de objetivos, de recursos técnicos, das práticas institucionais, e das das tentativas de inclusão social.

  16. A sputnik IV saga (United States)

    Lundquist, Charles A.


    The Sputnik IV launch occurred on May 15, 1960. On May 19, an attempt to deorbit a 'space cabin' failed and the cabin went into a higher orbit. The orbit of the cabin was monitored and Moonwatch volunteer satellite tracking teams were alerted to watch for the vehicle demise. On September 5, 1962, several team members from Milwaukee, Wisconsin made observations starting at 4:49 a.m. of a fireball following the predicted orbit of Sputnik IV. Requests went out to report any objects found under the fireball path. An early morning police patrol in Manitowoc had noticed a metal object on a street and had moved it to the curb. Later the officers recovered the object and had it dropped off at the Milwaukee Journal. The Moonwarch team got the object and reported the situation to Moonwatch Headquarters at the Smithsonian Astrophysical Observatory. A team member flew to Cambridge with the object. It was a solid, 9.49 kg piece of steel with a slag-like layer attached to it. Subsequent analyses showed that it contained radioactive nuclei produced by cosmic ray exposure in space. The scientists at the Observatory quickly recognized that measurements of its induced radioactivity could serve as a calibration for similar measurements of recently fallen nickel-iron meteorites. Concurrently, the Observatory directorate informed government agencies that a fragment from Sputnik IV had been recovered. Coincidently, a debate in the UN Committee on Peaceful Uses of Outer Space involved the issue of liability for damage caused by falling satellite fragments. On September 12, the Observatory delivered the bulk of the fragment to the US Delegation to the UN. Two days later, the fragment was used by US Ambassador Francis Plimpton as an exhibit that the time had come to agree on liability for damage from satellite debris. He offered the Sputnik IV fragment to USSR Ambassador P.D. Morozov, who refused the offer. On October 23, Drs. Alla Massevitch and E.K. Federov of the USSR visited the

  17. El coeficiente de Hurst y el parámetro a-estable para el análisis de series financieras. Aplicación al mercado cambiario mexicano

    Directory of Open Access Journals (Sweden)

    Román Rodríguez Aguilar


    Full Text Available Este trabajo aborda la utilidad de estimar, previo a cualquier análisis, el parámetro de la distribución -estable y el coe - ficiente de Hurst para una serie financiera en periodos de alta volatilidad. Mediante la estimación del coeficiente de Hurst y el parámetro se busca explorar la violación de dos grandes supuestos en la modelación de series financieras: suponer que las series presentan una distribución normal y que los rendi - mientos sucesivos son independientes; asimismo, se analiza el caso del tipo de cambio Fix peso-dólar en México en el perio - do 1992-2011. Uno de los principales resultados es la identi - ficación de características fractales y colas pesadas en la serie para algunos periodos en magnitudes diferenciadas; dichas diferencias se acentúan en periodos de crisis. Caracterizar la serie mediante estos parámetros a través de un índice permitirá mejorar la toma de decisiones sobre el tipo de análisis que es metodológicamente correcto aplicar en una ventana de tiempo específica, ya sea para valuación de activos o para la gestión de riesgos.

  18. Diaquatetrabromidotin(IV trihydrate

    Directory of Open Access Journals (Sweden)

    Fei Ye


    Full Text Available The title compound, [SnBr4(H2O2]·3H2O, forms large colourless crystals in originally sealed samples of tin tetrabromide. It constitutes the first structurally characterized hydrate of SnBr4 and is isostructural with the corresponding hydrate of SnCl4. It is composed of SnIV atoms octahedrally coordinated by four Br atoms and two cis-related water molecules. The octahedra exhibit site symmetry 2. They are arranged into columns along [001] via medium–strong O—H...O hydrogen bonds involving the two lattice water molecules (one situated on a twofold rotation axis while the chains are interconnected via longer O—H...Br hydrogen bonds, forming a three-dimensional network.

  19. 8th February 2011-Rector Universidad Autónoma de Sinaloa Mexico Dr Victor Antonio Corrales Burgeño-Mexico-visiting ALICE cavern and tunnel with ALICE Spokesperson P. Giubellino

    CERN Multimedia

    Maximilien Brice


    Photo 1,3-14:The delegation visiting ALICE cavern Photo 2:Dra. Beatriz E. Rodríguez Pérez\tDirectora del Centro de Políticas de Género para la igualdad entre Hombres y Mujeres,Dr Victor Antonio Corrales Burgeño,P. Giubellino Photo 15-29:The delegation visiting LHC Tunnel Photo 30-57:Signature of the Guest Book with CERN Director-General R. Heuer and Head of International Relations F. Pauss Photo 58:Adviser for Mexico J. Salicio,ALICE Collaboration Universidad Autonoma de Sinaloa I. Leon Monzon,ALICE Collaboration Centro Invest. Estudios Avanz. IPN (Cinnestav) G. Herrera Corral,R. Heuer,Dr Victor Antonio Corrales Burgeño,F. Pauss,Dra. Beatriz E. Rodríguez Pérez,Directora de Relaciones InternacionalesMC. América M. Lizárraga González

  20. Peace Studies in Russia: Origins, Current Status and Trends. Interview with Professor Victor A. Kremenyuk, Institute for the U.S. and Canadian Studies, Russian Academy of Science

    Directory of Open Access Journals (Sweden)

    Olga Sergeevna Chikrizova


    Full Text Available The interview is devoted to analysis of peculiarities of Peace Studies in Russia and methodology of the present-day conflicts resolution. The scientist is concerning prerequisites of the origin of the Soviet school of peace studies during the Cold War when the problem of resources exhaustion arouse. Victor A. Kremenyuk uncovers differences between Russian and Western schools of peace studies. The researcher reviews specificities of resolution process for the most difficult present0day conflicts, especially knot of contradictions in the Middle East and crisis in Russia - U.S. relations. The scientist emphasizes importance of control over the conflict status and negotiations as a tool of conflict resolution. He focuses on a complexity of a conflict resolution process and necessity to take into account a lot of different factors during negotiations, and also how important for the Great Powers to realize their global responsibility. By the example of IIASA the researcher demonstrates a role of such international scientific centers as a link between scientific community and authorities.

  1. Dioxobridged complexes of molybdenum (IV) and tungsten (IV) with ...

    Indian Academy of Sciences (India)

    Abstract. Six new dioxobridged complexes of molybdenum (IV) and tungsten (IV) with N-alkylphenothiazines having the general formula M2O4(L)2(H2O)2 [where M = molybdenum or tungsten and L = N-alkylphenothiazines] have been synthesised. The complexes have been characterised on the basis of analytical, molar ...

  2. The Orthodox Doctrine of Salvation» by Archimandrite Sergius (Stragorodsky and its criticism by Confessor of the Faith Victor (Ostrovidov and Archbishop Seraphim (Sobolev

    Directory of Open Access Journals (Sweden)



    Full Text Available «The Orthodox Doctrine of Salvation», a well-known work by Archimandrite Sergius (Stragorodsky that was defended by him as a master’s thesis at the Moscow Theological Academy in 1895, is still considered an etalon in Orthodox theology. Meanwhile, in the first half of the 20th century, it was heavily criticized by at least two prominent members of the Church hierarchy of that time: Confessor of the Faith Victor (Ostrovidov and Archbishop Seraphim (Sobolev. This article does not only examine their arguments, but also provides the researcher’s personal understanding of the main theses of the work by Archimandrite Sergius. The researcher’s work in this case is complicated by a large number of patristic texts, which are given by Archimandrite Sergius and the abundance of which hampers the identification of his own original ideas. Nevertheless, the carried out analysis reveals that the dissertation doesn’t contain not only patristic, but any kind of a clear doctrine of the Fall, or of man’s state after the Fall, or of redemption, or of man’s assimilation of redemption fruits. Besides, the theses illustrated in the dissertation by the texts of the Holy Fathers belong not so much to them as to the first Slavophiles, Archimandrite Anthony (Khrapovitsky, the teacher and the senior friend of Archimandrite Sergius, and finally to Immanuel Kant. Consequently, in his doctrine of freedom anticipating grace, Archimandrite Sergius comes dangerously close to Pelagianism. These findings recognize the truth of complaints against the work of Archimandrite Sergius by Confessor of the Faith Viktor (Ostrovidov and Archbishop Seraphim (Sobolev.

  3. The Modern RPG IV Language

    CERN Document Server

    Cozzi, Robert


    This updated, classic work on the RPG language covers all the new functions and features that have been added since 2003, including new op codes and built-in functions, new chapters on free-format RPG IV and Web programming interfaces, information on implementing XML within RPG IV, and expanded information on procedures. This reference guide takes both novice and experienced RPG IV programmers through the language, from its foundation to its most advanced techniques. More than 100 charts and tables, as well as 350 real-life code samples of functions and operations are included, showing readers

  4. A composição e interpretação de Victor Assis Brasil em Pro Zeca: hibridismo entre o baião e o bebop The composition and interpretation by Victor Assis Brasil in Pro Zeca: hybridism between the Brazilian baião and bebop

    Directory of Open Access Journals (Sweden)

    Leonardo Barreto Linhares


    Full Text Available Estudo sobre o reconhecimento de elementos composicionais e interpretativos característicos do baião e do bebop na Introdução e Tema da música Pro Zeca de Victor Assis Brasil (1945-1981, a partir de três fontes primárias: (1 a lead sheet editada que reproduz o manuscrito autógrafo do compositor (ASSIS BRASIL, sem data a, (2 uma lead sheet manuscrita de caligrafia anônima (ASSIS BRASIL, sem data b e (3 a lead sheet editada da transcrição a partir da gravação do compositor (ASSIS BRASIL, 1974, incluindo sua improvisação, que está publicada às p.39-44 nesse volume de Per Musi. Fundamentada por referenciais históricos e teóricos das práticas de performance da música brasileira (GIF-FONI, 1997; SIQUEIRA, 1981; SÉVE, 1999 e do jazz (GRIDLEY, 2006; LAWN, 1995; HOBSBAWM, 1990, BAKER, 1987, esta análise comparativa revela um hibridismo entre elementos do bebop e do baião, no qual as características desses dois gêneros populares de países diferentes às vezes permanecem distintas e às vezes se entrelaçam em uma síntese.Study about the recognition of compositional and intrepretive elements typical of bebop and baião in the Introduction and Theme of Pro Zeca by Brazilian composer and saxophonist Victor Assis Brasil (1945-1981 departing from three primary sources: (1 the edited lead sheet that reproduces the composer's autograph (ASSIS BRASIL, sem data a, (2 an anonymous lead sheet manuscript (ASSIS BRASIL, sem data b and (3 the lead sheet of the transcription based on the composer's recording (ASSIS BRASIL, 1974 included at the end of this article. Resorting to historical and theoretical references of performance practices in jazz (GRIDLEY, 2006; LAWN, 1995; HOBSBAWM, 1990, BAKER, 1987 and Brazilian music (GIFFONI, 1997; SIQUEIRA, 1981; SÉVE, 1999, this comparative analysis reveals hybridization between bebop and the Brazilian baião, in which the characteristics of these popular genres from two different countries sometimes

  5. Dramatically different dizygotic twins: will we include them in Research? Twin research reviews: congenital anomalies, mirror-image effects in conjoined twins, older mothers of twins; Twin statistics: 'Massachusetts, land of twins'; Tribute: Dr Victor A. McKusick. (United States)

    Segal, Nancy L


    The increased frequency of interracial marriage is a likely source of unusual-looking dizygotic (DZ) twins. Some members of DZ twin pairs born to mixed-race couples inherit very different physical features from their parents. This raises several questions, such as: Will researchers wish to include such twins in their ongoing studies? Next, new twin research concerned with congenital anomalies, mirror-image effects in conjoined twins and older mothers of twins will be reviewed. New statistics on twinning rates in Massachusetts will also be summarized, followed by a tribute to the late medical geneticist Dr. Victor A. McKusick.

  6. Berry, Prof. Sir Michael Victor

    Indian Academy of Sciences (India)

    Address: Professor of Physics, HH Wills Physics Laboratory, University of Bristol, Royal Fort, Tyndall Avenue, Bristol BS8 1TL, U.K.. Contact: Office: (+44-117) 928 8778. Residence: (+44-117) 973 2240. Fax: (+44-117) 925 5624. Email: · YouTube · Twitter ...

  7. Free-format RPG IV

    CERN Document Server

    Martin, Jim


    This how-to guide offers a concise and thorough introduction to the increased productivity, better readability, and easier program maintenance that comes with the free-format style of programming in RPG IV. Although free-format information is available in IBM manuals, it is not separated from everything else, thereby requiring hours of tedious research to track down the information needed. This book provides everything one needs to know to write RPG IV in the free-format style, and author Jim Martin not only teaches rules and syntax but also explains how this new style of coding has the pot

  8. 11. IV avati Draakoni galeriis...

    Index Scriptorium Estoniae


    Tanel Saare (sünd. 1979) näitus "Gott und huhn episode IV: seed shower". Eksponeeritakse väljavõtteid aktsioonidest aastatel 2000-2004 Turus, Nürnbergis, Berliinis, Lohusalus ja Soulis. Osa aktsioone toimus koos rühmitusega Non Grata

  9. Twin Legacies: Victor and Vincent McKusick/Twin Studies: Twinning Rates I; Twinning Rates II; MZ Twin Discordance for Russell-Silver Syndrome; Twins' Language Skills/Headlines: Babies Born to Identical Twin Couples; Identity Exchange; Death of Princess Ashraf (Twin); Yahoo CEO Delivers Identical Twins. (United States)

    Segal, Nancy L


    The lives of the illustrious monozygotic (MZ) twins, Victor A. and Vincent L. McKusick, are described. Victor earned the distinction as the 'Father of Medical Genetics', while Vincent was a legendary Chief Justice of the Maine Supreme Court. This dual biographical account is followed by two timely reports of twinning rates, a study of MZ twin discordance for Russell-Silver Syndrome (RSS) and a study of twins' language skills. Twin stories in the news include babies born to identical twin couples, a case of switched identity, the death of Princess Ashraf (Twin) and a new mother of twins who is also Yahoo's CEO.

  10. Alle har en historie, IV

    DEFF Research Database (Denmark)

    Ydegaard, Torbjørn

    Alle har en historie IV: Pædagogik med Freedom Writers lader et væld af pædagogiske facetter udspringe af den kendte skole-film Freedom Writers’ scener og handlinger. Der er både fokus på en almen tilgang til pædagogik og på Freedom Writer-metodikken, dels gennem de filmscener, der sættes til...

  11. Genetics Home Reference: mucopolysaccharidosis type IV (United States)

    ... types of mucopolysaccharidosis, MPS IV does not affect intelligence. The life expectancy of individuals with MPS IV ... GM1-gangliosidosis and Morquio B patients: possible common origin for the prevalent p.R59H mutation among gypsies. ...

  12. Los lugares de lo político, los desplazamientos del símbolo. Poder y simbolismo en la obra de Victor W. Turner, de Rodrigo Díaz Cruz

    Directory of Open Access Journals (Sweden)

    Dario Ranocchiari


    Full Text Available Este es un libro que hacía falta desde hace mucho tiempo. Puede que eso quiera decir —como sugiere el autor en la introducción— que habría sido mejor si se hubiese publicado hace veinte o treinta años, pero mi opinión es que no hay momentos mejores de este para redescubrir la obra de Victor Turner (1920-1983. ¿Habrían tenido que publicarse ya en los 1970 y 1980 estudios críticos analíticos y bien fundamentados sobre las muchas almas de la antropología turneriana? Sí, indudablemente. Pero la lectura que de ella nos proporciona en 2014 Rodrigo Díaz Cruz no habría podido hacerse en pleno auge de la antropología interpretativa o de la posmoderna.

  13. 21 CFR 1308.14 - Schedule IV. (United States)


    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Schedule IV. 1308.14 Section 1308.14 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE SCHEDULES OF CONTROLLED SUBSTANCES Schedules § 1308.14 Schedule IV. (a) Schedule IV shall consist of the drugs and other substances, by...

  14. The Titan IV launch vehicle (United States)

    Morrissey, Arthur C.; O'Neill, Stephen T.


    Titan launch vehicles have been contributing to the national space accomplishments for more than 20 years. As the U.S. space program has grown, the Titan family has expanded to meet the changing requirements. The dependability and versatility of Titan vehicles have been demonstrated by their selection for various missions, including strategic intercontinental ballistic missile weapon systems, manned Gemini space flights, NASA interplanetary missions, and critical national security programs. This article summarizes the Titan legacy and is an overview of the newest Titan family member - the Titan IV.

  15. A Gaussian IV estimator of cointegrating relations

    DEFF Research Database (Denmark)

    Bårdsen, Gunnar; Haldrup, Niels


    -nonparametricestimators. Theoretically ideal instruments can be defined to ensure a limitingGaussian distribution of IV estimators, but unfortunately such instruments areunlikely to be found in real data. In the present paper we suggest an IV estimatorwhere the Hodrick-Prescott filtered trends are used as instruments forthe regressors...

  16. IVS Working Group 4: VLBI Data Structures (United States)

    Gipson, John


    In 2007 the IVS Directing Board established IVS Working Group 4 on VLBI Data Structures. This note discusses the current VLBI data format, goals for a new format, the history and formation of the Working Group, and a timeline for the development of a new VLBI data format.

  17. Thermodynamic data for predicting concentrations of Th(IV), U(IV), Np(IV), and Pu(IV) in geologic environments

    Energy Technology Data Exchange (ETDEWEB)

    Rai, Dhanpat; Roa, Linfeng; Weger, H.T.; Felmy, A.R. [Battelle, Pacific Northwest National Laboratory (PNNL) (United States); Choppin, G.R. [Florida State University (United States); Yui, Mikazu [Waste Isolation Research Division, Tokai Works, Japan Nuclear Cycle Development Inst., Tokai, Ibaraki (Japan)


    This report provides thermodynamic data for predicting concentrations of Th(IV), U(IV), Np(IV), and Pu(IV) in geologic environments, and contributes to an integration of the JNC chemical thermodynamic database, JNC-TDB (previously PNC-TDB), for the performance analysis of geological isolation system for high-level radioactive wastes. Thermodynamic data for the formation of complexes or compounds with hydroxide, chloride, fluoride, carbonate, nitrate, sulfate and phosphate are discussed in this report. Where data for specific actinide(IV) species was lacking, the data were selected based on chemical analogy to other tetravalent actinides. In this study, the Pitzer ion-interaction model is used to extrapolate thermodynamic constants to zero ionic strength at 25degC. (author)

  18. Surprising Coordination Geometry Differences in Ce(IV)- and Pu(IV)-Maltol Complexes

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence Berkeley National Laboratory; Raymond, Kenneth; Szigethy, Geza; Xu, Jide; Gorden, Anne E.V.; Teat, Simon J.; Shuh, David K.; Raymond, Kenneth N.


    As part of a study to characterize the detailed coordination behavior of Pu(IV), single crystal X-ray diffraction structures have been determined for Pu(IV) and Ce(IV) complexes with the naturally-occurring ligand maltol (3-hydroxy-2-methyl-pyran-4-one) and its derivative bromomaltol (5-bromo-3-hydroxy-2-methyl-pyran-4-one). Although Ce(IV) is generally accepted as a structural analog for Pu(IV), and the maltol complexes of these two metals are isostructural, the corresponding bromomaltol complexes are strikingly different with respect to ligand orientation about the metal ion: All complexes exhibit trigonal dodecahedral coordination geometry but the Ce(IV)-bromomaltol complex displays an uncommon ligand arrangement not mirrored in the Pu(IV) complex, although the two metal species are generally accepted to be structural analogs.

  19. Interactions between oxovanadium (IV), glycylvaline and imidazoles ...

    Indian Academy of Sciences (India)


    made using the SCOGS computer program. Keywords. Oxovanadium (IV); glycylvaline; imidazoles. 1. Introduction. The aqueous chemistry of vanadium has been attracting interest for many years. Solution equilibria involving oxovanadium can be followed very conveniently using potentiometry and EPR spectroscopy.

  20. Effects of DFA IV in rats: calcium absorption and metabolism of DFA IV by intestinal microorganisms. (United States)

    Saito, K; Hira, T; Suzuki, T; Hara, H; Yokota, A; Tomita, F


    Di-D-fructose-2,6':6,2'-dianhydride (DFA IV) is a disaccharide consisting of two fructose residues that can be prepared from levan by levan fructotransferase from Arthrobacter nicotinovorans GS-9, and it can be expected to have novel physiological functions from its unique structure. In this study, the effects of DFA IV on calcium absorption and the metabolism of DFA IV by intestinal microorganisms were studied in rats to examine the physiological functions of DFA IV. The apparent calcium absorption in rats fed with DFA IV was significantly higher than that in the control rats, and it seems that calcium absorption had almost been completed at the end of the small intestine. DFA IV also increased the calcium absorption in in vitro experiments, using everted jejunal and ileal sacs, and this result supports the finding obtained in the in vivo experiments. These results indicate that DFA IV may have a function for increasing the calcium absorption in the small intestine of rats. However, the effect in the large intestine could not be clearly observed because of the lack of calcium that reached there. The results of analyses of organic acids in the cecal and colonic contents and of DFA IV in the fecal, cecal, and colonic contents showed that the metabolism of DFA IV by microorganisms in the large intestine progressed gradually, and that DFA IV was converted mainly to acetate, butyrate, and lactate.

  1. Mirizzi Syndrome Type IV: A challenging diagnosis

    Directory of Open Access Journals (Sweden)

    Daniel Navarini


    Full Text Available Mirizzi Syndrome type IV is an extremely rare condition, which is confused with the diagnosis of cholangiocarcinoma in many cases. This report describes a case of a forty-three-year old patient, who was forwarded to our department of general surgery with a high suspicion of a choledochal neoplasic lesion. During the hospitalization he was diagnosed with Mirizzi Syndrome type IV. We concisely describe the case and the literature review about this pathology.

  2. Observational properties of decameter type IV bursts (United States)

    Melnik, Valentin; Brazhenko, Anatoly; Rucker, Helmut; Konovalenko, Alexander; Briand, Carine; Dorovskyy, Vladimir; Zarka, Philippe; Frantzusenko, Anatoly; Panchenko, Michael; Poedts, Stefan; Zaqarashvili, Teimuraz; Shergelashvili, Bidzina


    Oscillations of decameter type IV bursts were registered during observations of solar radio emission by UTR-2, URAN-2 and NDA in 2011-2012. Large majority of these bursts were accompanied by coronal mass ejections (CMEs), which were observed by SOHO and STEREO in the visible light. Only in some cases decameter type IV bursts were not associated with CMEs. The largest periods of oscillations P were some tens of minutes. There were some modes of long periods of oscillations simultaneously. Periods of oscillations in flux and in polarization profiles were close. Detailed properties of oscillations at different frequencies were analyzed on the example of two type IV bursts. One of them was observed on April 7, 2011 when a CME happened. Another one (August 1, 2011) was registered without any CME. The 7 April type IV burst had two periods in the frames 75-85 and 35-85 minutes. Interesting feature of these oscillations is decreasing periods with time. The observed decreasing rates dP/dt equaled 0.03-0.07. Concerning type IV burst observed on August 1, 2011 the period of its oscillations increases from 17 min. at 30 MHz to 44 min. at 10 MHz. Connection of type IV burst oscillations with oscillations of magnetic arches and CMEs at corresponding altitudes are discussed. The work is fulfilled in the frame of FP7 project "SOLSPANET".

  3. Synthesis and characterization of chiral thorium(IV) and uranium(IV) benzamidinate complexes

    Energy Technology Data Exchange (ETDEWEB)

    Schoene, Sebastian; Maerz, Juliane; Kaden, Peter; Patzschke, Michael; Ikeda-Ohno, Atsushi [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Chemistry of the F-Elements


    Two chiral benzamidinate complexes of tetravalent actinides (Th(IV) and U(IV)) were synthesized using a salt metathesis reaction of the corresponding actinide(IV) tetrachlorides and the potassium salt of the chiral benzamidine (S,S)-N,N-Bis-(1-phenylethyl)-benzamidine ((S)-HPEBA). The structure of the complexes was determined with single crystal X-ray diffraction. These are the first examples of chiral amidinate complexes of actinides.

  4. Axis IV--psychosocial and environmental problems--in the DSM-IV. (United States)

    Ramirez, A; Ekselius, L; Ramklint, M


    The aim of this study was to further explore the properties of axis IV in the Diagnostic and statistical manual of mental disorders, 4th edition (DSM-IV). In a naturalistic cross-sectional design, a group (n = 163) of young (18-25 years old) Swedish psychiatric outpatients was assessed according to DSM-IV. Psychosocial and environmental problems/axis IV were evaluated through structured interviewing by a social worker and by self-assessment on a questionnaire. Reliability between professional assessment and self-assessment of axis IV was examined. Concurrent validity of axis IV was also examined. Reliability between professional and self-assessed axis IV was fair to almost perfect, 0.31-0.83, according to prevalence and bias-adjusted kappa. Categories of psychosocial stress and environmental problems were related to the presence of axis I disorders, co-morbidity, personality disorders and decreasing Global Assessment of Functioning (GAF) values. The revised axis IV according to DSM-IV seems to have concurrent validity, but is still hampered by limited reliability. © 2013 John Wiley & Sons Ltd.

  5. Catalytically defective ganglioside neuraminidase in mucolipidosis IV

    Energy Technology Data Exchange (ETDEWEB)

    Ben-Yoseph, Y.; Momoi, T.; Hahn, L.C.; Nadler, H.L. (Wayne State Univ., Detroit, MI (USA))


    Cultured skin fibroblasts from patients with mucolipidosis IV were found to be deficient in neuraminidase activity toward GDsub(la) and GDsub(lb) gangliosides radiolabelled in C/sub 3/ and C/sub 7/ analogs of their sialic acid residues. Neuraminidase activities toward 4-methylumbelliferyl-N-acetyl-neuraminic acid, neuraminlactose, and radiolabelled neuraminlactitol, fetuin and ..cap alpha../sub 1/-acid glycoprotein were within the range of normal controls. Fibroblasts from parents of patients with mucolipidosis IV demonstrated intermediate levels of ganglioside neuraminidase activity and normal levels of glycoprotein neuraminidase activity. The redidual acidic neuraminidase activity toward GDsub(1a) ganglioside in the patients' fibroblasts did not differ from that of controls in its pH optimum and thermostability, but had an abnormal apparent Ksub(m) which was about 18 times higher than that of the normal enzyme. These findings suggest that mucolipidosis IV is a ganglioside sialidosis due to a catalytically defective ganglioside neuraminidase.

  6. Confirmatory Factor Analysis of the WAIS-IV and WMS-IV in Older Adults (United States)

    Miller, Delyana I.; Davidson, Patrick S. R.; Schindler, Dwayne; Messier, Claude


    New editions of the Wechsler Adult Intelligence and Memory scales are now available. Yet, given the significant changes in these new releases and the skepticism that has met them, independent evidence on their psychometric properties is much needed but currently lacking. We administered the WAIS-IV and the Older Adult version of the WMS-IV to 145…

  7. Muscle Function in Osteogenesis Imperfecta Type IV. (United States)

    Veilleux, Louis-Nicolas; Darsaklis, Vasiliki B; Montpetit, Kathleen; Glorieux, Francis H; Rauch, Frank


    Results of previous studies suggest that children and adolescents with osteogenesis imperfecta (OI) type IV have muscle force deficits. However, muscle function remains to be objectively quantified in this population. This study aimed to assess upper and lower extremity muscle function in patients with OI type IV. It was carried out in the outpatient department of a pediatric orthopedic hospital; 27 individuals with OI type IV (7-21 years; 13 males), 27 age- and sex-matched individuals with OI type I, and 27 age- and sex-matched controls. Upper extremity muscle force was assessed with hydraulic hand dynamometry, and lower extremity muscle function (peak force per body weight and peak power per body mass) was measured by mechanography through five tests: multiple two-legged hopping, multiple one-legged hopping, single two-legged jump, chair-rise test, and heel-rise test. Upper-limb grip force was normal for patients with OI type IV when compared to height and sex reference data (average z-score = 0.17 ± 1.30; P = 0.88). Compared to age- and sex-matched controls, patients with OI type IV had approximately 30% lower-limb peak force and 50% peak power deficits (P values <0.05). At the lower-limb level, they had a 50% lower peak power than age- and sex-matched patients with OI type I (P < 0.05). Patients with OI type IV have normal upper-limb muscle force but a muscle function deficit at the lower-limb level. These results suggest that lower-limb muscle weakness may contribute to functional deficits in these individuals.

  8. Oxochloroalkoxide of the Cerium (IV and Titanium (IV as oxides precursor

    Directory of Open Access Journals (Sweden)

    Machado Luiz Carlos


    Full Text Available The Cerium (IV and Titanium (IV oxides mixture (CeO2-3TiO2 was prepared by thermal treatment of the oxochloroisopropoxide of Cerium (IV and Titanium (IV. The chemical route utilizing the Cerium (III chloride alcoholic complex and Titanium (IV isopropoxide is presented. The compound Ce5Ti15Cl16O30 (iOPr4(OH-Et15 was characterized by elemental analysis, FTIR and TG/DTG. The X-ray diffraction patterns of the oxides resulting from the thermal decomposition of the precursor at 1000 degreesC for 36 h indicated the formation of cubic cerianite (a = 5.417Å and tetragonal rutile (a = 4.592Å and (c = 2.962 Å, with apparent crystallite sizes around 38 and 55nm, respectively.

  9. Commencement Bay Study. Volume IV. Invertebrates. (United States)


    AD-AI12 555 DAMES AND MOORE SEATTLE WA* FIG 8/1 COMMENCEMENT BAY STUDY. VOLUME IV. INVERTEBRATES .(U)DEC 81 W M BAYLOCK, J P HOUGHTON DACW67-80-C-OIDI...December 1981 Volume IV, Invertebrates 6. PERFORMINO ORG. REPORT NUMBER 682-021-05 7. AUTHOR(*) S. CONTRACT OR GRANT NUmaER(S) DACW67-80-C-0101 S. PERFORMING... Invertebrates Air Quality, Birds Is. KEY WORDS (Continue an reverse old. It necomemy w red ty a b eek mireber) Salmonids Wetlands Noise Aesthetics Marine Fish

  10. Functions in Free-Format RPG IV

    CERN Document Server

    Martin, Jim


    Written especially for programmers adopting a free-format style, this manual explores the role of functions in writing RPG IV programs. Demonstrating the potential of functions, many topics are explored such as details about existing RPG IV built-in functions, writing new functions, using ILE concepts to use C functions, and utilizing IBM API's functions. Explaining how to write small programs, either as sub-procedures or modules, and how to gather those parts together to make programs that are easy to write and maintain, this is a natural next step for programmers familiar with a free-format

  11. 46 CFR Appendix IV to Part 150 - Data Sheet (United States)


    ... 46 Shipping 5 2010-10-01 2010-10-01 false Data Sheet IV Appendix IV to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, App. IV Appendix IV to Part 150—Data Sheet EC02FE91.080 EC02FE91.081 ...

  12. Expiry date guidelines for a centralized IV admixture service. (United States)

    Stroup, J W; Mighton-Eryou, L M


    Expiry date guidelines for a centralized pharmacy-based IV admixture program are documented. These guidelines form part of an overall quality assurance program for the IV admixture service. Factors affecting IV admixture expiry times include drug compatibility with the vehicle(s) and container, microbiological parameters, and established standards of practice for pharmacy-based IV admixture programs.

  13. Genetics Home Reference: mucolipidosis type IV (United States)

    ... it does result in unusually high levels of gastrin in the blood. Gastrin is a hormone that regulates the production of ... Resources (2 links) GeneReview: Mucolipidosis IV MedlinePlus Encyclopedia: Gastrin General Information from MedlinePlus (5 links) Diagnostic Tests ...

  14. ATHENA-IV. Inelastic Scattering Form Factors

    Energy Technology Data Exchange (ETDEWEB)

    Chwieroth, F.S.; Dodson, J.I.; Johnson, M.B.; Owen, L.W.; Satchler, G.R. [Oak Ridge National Lab., TN (United States)


    ATHENA-IV computes form factors for inelastic scattering calculations, using single-particle wave functions that are eigenstates of motion in either a Woods-Saxon potential well or a harmonic oscillator well. Two-body forces of Gauss, Coulomb, Yukawa, and a sum of cut-off Yukawa radial dependences are available.

  15. Industrial Waste Landfill IV upgrade package

    Energy Technology Data Exchange (ETDEWEB)


    The Y-12 Plant, K-25 Site, and ORNL are managed by DOE`s Operating Contractor (OC), Martin Marietta Energy Systems, Inc. (Energy Systems) for DOE. Operation associated with the facilities by the Operating Contractor and subcontractors, DOE contractors and the DOE Federal Building result in the generation of industrial solid wastes as well as construction/demolition wastes. Due to the waste streams mentioned, the Y-12 Industrial Waste Landfill IV (IWLF-IV) was developed for the disposal of solid industrial waste in accordance to Rule 1200-1-7, Regulations Governing Solid Waste Processing and Disposal in Tennessee. This revised operating document is a part of a request for modification to the existing Y-12 IWLF-IV to comply with revised regulation (Rule Chapters 1200-1-7-.01 through 1200-1-7-.08) in order to provide future disposal space for the ORR, Subcontractors, and the DOE Federal Building. This revised operating manual also reflects approved modifications that have been made over the years since the original landfill permit approval. The drawings referred to in this manual are included in Drawings section of the package. IWLF-IV is a Tennessee Department of Environmental and Conservation/Division of Solid Waste Management (TDEC/DSWM) Class 11 disposal unit.

  16. Painlevé IV coherent states

    Energy Technology Data Exchange (ETDEWEB)

    Bermudez, David, E-mail: [Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100 (Israel); Departamento de Física, Cinvestav, A.P. 14-740, 07000 México D.F. (Mexico); Contreras-Astorga, Alonso, E-mail: [Department of Mathematics and Actuarial Science, Indiana University Northwest, 3400 Broadway, Gary IN 46408 (United States); Departamento de Física, Cinvestav, A.P. 14-740, 07000 México D.F. (Mexico); Fernández C, David J., E-mail: [Departamento de Física, Cinvestav, A.P. 14-740, 07000 México D.F. (Mexico)


    A simple way to find solutions of the Painlevé IV equation is by identifying Hamiltonian systems with third-order differential ladder operators. Some of these systems can be obtained by applying supersymmetric quantum mechanics (SUSY QM) to the harmonic oscillator. In this work, we will construct families of coherent states for such subset of SUSY partner Hamiltonians which are connected with the Painlevé IV equation. First, these coherent states are built up as eigenstates of the annihilation operator, then as displaced versions of the extremal states, both involving the related third-order ladder operators, and finally as extremal states which are also displaced but now using the so called linearized ladder operators. To each SUSY partner Hamiltonian corresponds two families of coherent states: one inside the infinite subspace associated with the isospectral part of the spectrum and another one in the finite subspace generated by the states created through the SUSY technique. - Highlights: • We use SUSY QM to obtain Hamiltonians with third-order differential ladder operators. • We show that these systems are related with the Painlevé IV equation. • We apply different definitions of coherent states to these Hamiltonians using the third-order ladder operators and some linearized ones. • We construct families of coherent states for such systems, which we called Painlevé IV coherent states.

  17. Bis(4-methylpiperidinium hexachloridostannate(IV

    Directory of Open Access Journals (Sweden)

    Madeleine Helliwell


    Full Text Available The crystal structure of the title compound, (C6H14N2[SnCl6], is built of 4-methylpiperidinium cations, occupying special positions on the mirror plane, and hexachloridostannate(IV anions on a special position of 2/m symmetry. The ions are linked via N—H...Cl hydrogen bonds into chains running along the b axis.

  18. Gen IV Materials Handbook Implementation Plan

    Energy Technology Data Exchange (ETDEWEB)

    Rittenhouse, P.; Ren, W.


    A Gen IV Materials Handbook is being developed to provide an authoritative single source of highly qualified structural materials information and materials properties data for use in design and analyses of all Generation IV Reactor Systems. The Handbook will be responsive to the needs expressed by all of the principal government, national laboratory, and private company stakeholders of Gen IV Reactor Systems. The Gen IV Materials Handbook Implementation Plan provided here addresses the purpose, rationale, attributes, and benefits of the Handbook and will detail its content, format, quality assurance, applicability, and access. Structural materials, both metallic and ceramic, for all Gen IV reactor types currently supported by the Department of Energy (DOE) will be included in the Gen IV Materials Handbook. However, initial emphasis will be on materials for the Very High Temperature Reactor (VHTR). Descriptive information (e.g., chemical composition and applicable technical specifications and codes) will be provided for each material along with an extensive presentation of mechanical and physical property data including consideration of temperature, irradiation, environment, etc. effects on properties. Access to the Gen IV Materials Handbook will be internet-based with appropriate levels of control. Information and data in the Handbook will be configured to allow search by material classes, specific materials, specific information or property class, specific property, data parameters, and individual data points identified with materials parameters, test conditions, and data source. Details on all of these as well as proposed applicability and consideration of data quality classes are provided in the Implementation Plan. Website development for the Handbook is divided into six phases including (1) detailed product analysis and specification, (2) simulation and design, (3) implementation and testing, (4) product release, (5) project/product evaluation, and (6) product

  19. 621-IJBCS-Article-Prof Victor Pwema

    African Journals Online (AJOL)


    TAKOY LOMEMA1 and Jean-Claude MICHA 2. 1Unité de Limnologie, Hydrobiologie et Aquaculture, Université de Kinshasa, Faculté des Sciences. B.P.190 Kinshasa. XI, R.D. Congo. 2Unité de Recherche en Biologie des Organismes (URBO), University of Namur (FUNDP). 61 Rue de Bruxelles, 5000. Namur, Belgique.

  20. 1661-IJBCS-Article-Victor Kimpouni

    African Journals Online (AJOL)


    Au cours de cet inventaire, un herbier d'une cinquantaine d'espèces a été constitué et déposé à ...... Jardin Botanique. National de Belgique : Bruxelles. Peters CM. 1997. Exploitation soutenue de produits forestiers autres que le bois en forêt tropicale humide : manuel d'initiation écologique. Programme d'appui à la ...

  1. Ben jij een Vincent of een Victor?

    NARCIS (Netherlands)

    drs. Frans van den Reep


    1e alinea column: "Laat het streven naar volmaaktheid los; in alles zit een barst. Zo komt het licht naar binnen." Louise Penny. Internet brengt ons in de "personal age" zei ik ooit in mijn entreerede. Inderdaad, in andere woorden 'CEO over eigen leven en werk'. In die "age" hangt steeds meer af van

  2. 1933-IJBCS-Article-Victor Okombe

    African Journals Online (AJOL)


    Cent vingt-quatre caprins sélectionnés dans deux fermes de la région de Lubumbashi en R.D. Congo, ont été examinés en utilisant le test de réduction de l'excrétion fécale des œufs de strongles dans les fèces afin de détecter une résistance éventuelle aux anthelminthiques utilisés. Dans les deux fermes, il a été suspecté ...

  3. Obituario: El doctor Victor Manuel Ferrans

    Directory of Open Access Journals (Sweden)

    Alfredo Jácome Roca


    Full Text Available

    A finales del año pasado falleció en los Estados Unidos el médico colombiano Víctor Ferrans, quien dedicó su vida entera a la investigación en biología molecular.

    “Vic” (como le decían sus contemporáneos norteamericanos nació en Barranquilla en la década de los 30. Con raíces catalanas, se graduó de bachiller en el tradicional Colegio Biffi de los Hermanos Cristianos; viajó a New Orleans, donde se graduó de médico en la Universidad de Tulane e hizo su internado en el Charity Hospital de la misma ciudad.

    En vez de proseguir con una tradicional residencia en campos clínicoquirúrgicos que le hubieran garantizado una vida sin aulagas, decidió sacar un doctorado en anatomía, en su misma Alma Mater.

    Los colombianos éramos particularmente apreciados en aquel sitio, merced a programas como el “Tulane-Colombia” (ahora Cideim en Cali, orientado hacia el estudio de las enfermedades tropicales, y a la presencia de decenas de profesionales becados para hacer postgrados allí (que en nuestro país adquirirían luego el remoquete de los “Tulane boys”.

    Numerosas personas saltan a mi memoria, entre las que se encuentran Eduardo Gaitán, Germán Beltrán, Eugenio González, Ramsés Hakim, Alfonso Villamil, Jorge León, su hermana María Amalia y los hermanos Alberto y Mario Bernal, Oscar Bolaños, Mario Hurtado y muchos otros, que pasamos por aquellos claustros y residimos en esa interesante ciudad. Yo lo hice entre 1965 y 1967, cuando compartí trabajo y amistad con mi paisano Ferrans.

    Casado con la también barranquillera Gloria Grocer, Víctor se ubicó en el grupo del Profesor George E. Burch, jefe de Medicina Interna y eminente cardiólogo e investigador.

    Sus primeros “papers” llevaron la co-autoría de Burch, entre los que recuerdo uno sobre la necesidad de tratar las cardiomiopatìas dilatadas que se observaban en situaciones como los embarazos, con reposo estricto y prolongado, hasta por seis meses. Como Burch exigía que todo médico vinculado al Departamento hiciera consulta externa y pasara revista (o “rounds”, así se dedicara a la investigación, allí los residentes y fellows veíamos a grandes científicos participando en jornadas de un corte eminentemente clínico, lo que a su vez enriquecía nuestro aprendizaje...

  4. 1049-IJBCS-Article-Kimpauri Victor

    African Journals Online (AJOL)


    la pérennisation des savoirs des peuples autochtones et locaux dont le caractère désuet ne fait aucun doute. Cette étude montre que toutes les populations forestières, du nord au sud, exploitent pour une même fin, les mêmes espèces à quelques exceptions près. Aussi, elle met un accent particulier sur les savoirs.

  5. 533-IJBCS-Article-Prof Victor Deffo

    African Journals Online (AJOL)

    Dr Gatsing

    ABSTRACT. A study was carried out to determine the best forage production period for cattle farming in the Adamawa (Cameroon). ... Keywords: decision making tool, diachronic observation, high forage quality, cattle performance, economic gain. ..... dermatophilosis, tick-borne diseases and foot- and-mouth disease), are ...

  6. 842-IJBCS-Article-Victor Olugbue

    African Journals Online (AJOL)


    The prevalence and antibiotic sensitivity pattern of bacterial agents involved in Lower Respiratory Tract. Infections (LRTI) was investigated. A total of ..... respiratory tract due to smoking, use of tobacco, alcohol consumption etc. This study ... immune system resulting in malnutrition or degenerative diseases such as diabetic.

  7. 1790-IJBCS-Article-Victor Okombe

    African Journals Online (AJOL)


    The effects of birdsfoot trefoil (Lotus corniculatus) and chicory (Chicorium intybus) when compared with perennial ryegrass. (Lolium perenne) on ovine gastrointestinal parasite development, survival and migration. Vet. Parasitol.,. 138(3-4): 280-290. Mihranian VH, Abou-Chaar CI. 1968. Extraction, detection and estimation of.

  8. 2198-IJBCS-Article -Victor barku

    African Journals Online (AJOL)


    A preliminary study had shown that C. olitorius has analgesic activity possibly mediated through opioidergic pathway. The study was a follow up work to evaluate the anti-nociceptive effects and other possible mechanisms of action of an aqueous leaf extract of C. olitorius (COE) using formalin-induced nociception test.

  9. 1751-IJBCS-Article-Ayantade Ayansina Victor

    African Journals Online (AJOL)


    days after application at 150 ppm and at 12 days after application at 100 ppm. ... mis-used (ICI, 1978; Alexander, 1995). As a .... Application of 2,4-D resulted in decrease in pH at all concentrations. However, paraquat application resulted in significant increases in the pH values at all levels of concentrations (P<0.05).

  10. 1693-IJBCS-Article-Houndji Bidossessi Victor

    African Journals Online (AJOL)


    produite ne subit aucun autre traitement spécial et est exempte d'additifs alimentaires. Ce mode de production des protéines foliaires avait été décrit précédemment par Amorigi. (1980) et Houinsou (1990) dans les opérations de séchage des fruits et légumes. Echantillonnage de la PFMo. Un lot de cinq échantillons de 100 ...

  11. 1693-IJBCS-Article-Houndji Bidossessi Victor

    African Journals Online (AJOL)


    des produits laitiers, des fruits et légumes. (Barro et al., 2002). Cependant, les charges observées pour les germes aérobies mésophiles sont restés en deçà des normes admises pendant toute la durée de conservation. Les tendances observées au niveau de la charge en coliformes méritent d'être investiguées par des ...

  12. 2020-IJBCS-Article-Victor Kimpouri

    African Journals Online (AJOL)


    grouping bases on the methods “even Average linkage or .... 10.54. 9. 12.68. 9.10. 0.36. 36.40. 1.4. 106. 8.94. 11. 15.49. 8.99. 0.36. 35.96. Average. 131. 11.05. 9.25. 13.03. 8.70. 0.35. 34.79. Standard error. 12.8. 1.1. 0.7. 1.0. 1.9. 0.03 .... Figure 8: Hierarchical classification of the subplots according to the nearest neighbour.

  13. Ehlers-Danlos syndrome type IV

    Directory of Open Access Journals (Sweden)

    Germain Dominique P


    Full Text Available Abstract Ehlers-Danlos syndrome type IV, the vascular type of Ehlers-Danlos syndromes (EDS, is an inherited connective tissue disorder defined by characteristic facial features (acrogeria in most patients, translucent skin with highly visible subcutaneous vessels on the trunk and lower back, easy bruising, and severe arterial, digestive and uterine complications, which are rarely, if at all, observed in the other forms of EDS. The estimated prevalence for all EDS varies between 1/10,000 and 1/25,000, EDS type IV representing approximately 5 to 10% of cases. The vascular complications may affect all anatomical areas, with a tendency toward arteries of large and medium diameter. Dissections of the vertebral arteries and the carotids in their extra- and intra-cranial segments (carotid-cavernous fistulae are typical. There is a high risk of recurrent colonic perforations. Pregnancy increases the likelihood of a uterine or vascular rupture. EDS type IV is inherited as an autosomal dominant trait that is caused by mutations in the COL3A1 gene coding for type III procollagen. Diagnosis is based on clinical signs, non-invasive imaging, and the identification of a mutation of the COL3A1 gene. In childhood, coagulation disorders and Silverman's syndrome are the main differential diagnoses; in adulthood, the differential diagnosis includes other Ehlers-Danlos syndromes, Marfan syndrome and Loeys-Dietz syndrome. Prenatal diagnosis can be considered in families where the mutation is known. Choriocentesis or amniocentesis, however, may entail risk for the pregnant woman. In the absence of specific treatment for EDS type IV, medical intervention should be focused on symptomatic treatment and prophylactic measures. Arterial, digestive or uterine complications require immediate hospitalisation, observation in an intensive care unit. Invasive imaging techniques are contraindicated. Conservative approach is usually recommended when caring for a vascular

  14. Ehlers-Danlos syndrome type IV (United States)

    Germain, Dominique P


    Ehlers-Danlos syndrome type IV, the vascular type of Ehlers-Danlos syndromes (EDS), is an inherited connective tissue disorder defined by characteristic facial features (acrogeria) in most patients, translucent skin with highly visible subcutaneous vessels on the trunk and lower back, easy bruising, and severe arterial, digestive and uterine complications, which are rarely, if at all, observed in the other forms of EDS. The estimated prevalence for all EDS varies between 1/10,000 and 1/25,000, EDS type IV representing approximately 5 to 10% of cases. The vascular complications may affect all anatomical areas, with a tendency toward arteries of large and medium diameter. Dissections of the vertebral arteries and the carotids in their extra- and intra-cranial segments (carotid-cavernous fistulae) are typical. There is a high risk of recurrent colonic perforations. Pregnancy increases the likelihood of a uterine or vascular rupture. EDS type IV is inherited as an autosomal dominant trait that is caused by mutations in the COL3A1 gene coding for type III procollagen. Diagnosis is based on clinical signs, non-invasive imaging, and the identification of a mutation of the COL3A1 gene. In childhood, coagulation disorders and Silverman's syndrome are the main differential diagnoses; in adulthood, the differential diagnosis includes other Ehlers-Danlos syndromes, Marfan syndrome and Loeys-Dietz syndrome. Prenatal diagnosis can be considered in families where the mutation is known. Choriocentesis or amniocentesis, however, may entail risk for the pregnant woman. In the absence of specific treatment for EDS type IV, medical intervention should be focused on symptomatic treatment and prophylactic measures. Arterial, digestive or uterine complications require immediate hospitalisation, observation in an intensive care unit. Invasive imaging techniques are contraindicated. Conservative approach is usually recommended when caring for a vascular complication in a patient suffering

  15. On the stabilization of niobium(V) solutions by zirconium(IV) and hafnium(IV)

    DEFF Research Database (Denmark)

    Sørensen, E.; Bjerre, A.B.


    Niobium cannot be separated from zirconium or hafnium when these elements occur together in solution with common anions such as chloride and sulphate. This is ascribed to the co-polymerization of niobium(V) and the hydrolysed ionic species of zirconium(IV) and hafnium(IV) to form colloidal partic...... particles. In hydrochloric acid the particles are positively charged, whereas in sulphate solution the Zr- and Hf-sulphate complexes confer a negative charge. The two cases are considered separately....

  16. Kategorizace léčiv


    Slanařová, Eliška Bc.


    Farmaceutický průmysl je velmi prestižním odvětvím, ve kterém se točí spousta peněz. Pro rok 2006 bylo za léčiva utraceno 64 miliard Kč. Kategorizace léčiv je jedním z nástrojů lékové politiky, jak zamezit stále rostoucím nákladům na farmakoterapii. Práce podává souhrnný přehled o jednotlivých stakeholders v oblasti lékové politiky, vývoji lékové politiky v ČR, spotřebě léčiv a celkově analyzuje situaci v ČR.

  17. Dipyridinium tribromidochloridobis(4-chlorophenylstannate(IV

    Directory of Open Access Journals (Sweden)

    Kong Mun Lo


    Full Text Available The tin atom in the substituted ammonium stannate(IV, (C5H6N2[SnBr3(C6H4Cl2Cl], lies on a center of symmetry in a distorted octahedral coordination geometry. Each independent halogen site is occupied by bromine and chlorine anions in an approximate 3:1 ratio. The pyridinium cation forms a hydrogen bond to only one of the halogen atoms.

  18. Annotations on Mexico's WISC-IV: a validity study. (United States)

    Fina, Anthony D; Sánchez-Escobedo, Pedro; Hollingworth, Liz


    This project seeks to provide evidence on the internal structure of the Escala Wechsler de Inteligencia para Niños-IV (EWIN-IV; Wechsler, 2007a ) through a confirmatory factor analysis and intercorrelational study. Also provided is information on the adaptation process and other sources of validity evidence in support of the EWIN-IV norms. The standardization data for the EWIN-IV were used for all analyses. The factor loadings and correlational patterns found on the EWIN-IV are comparable to those seen in the American versions of the test. The proposed factor and scoring structure of the EWIN-IV was supported.

  19. 21 CFR 880.5025 - I.V. container. (United States)


    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false I.V. container. 880.5025 Section 880.5025 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES... I.V. container. (a) Identification. An I.V. container is a container made of plastic or glass used...

  20. 78 FR 18325 - Defense Transportation Regulation, Part IV (United States)


    ... Transportation Regulation, Part IV Web site at (DPM SECTION... published in the Federal Register and incorporated into the Defense Transportation Regulation (DTR) Part IV (DTR 4500.9R). These program requirements do not impose a legal requirement, obligation, sanction or...

  1. Synthesis and characterization of thorium(IV) and uranium(IV) complexes with Schiff bases

    Energy Technology Data Exchange (ETDEWEB)

    Radoske, Thomas; Maerz, Juliane; Kaden, Peter; Patzschke, Michael; Ikeda-Ohno, Atsushi [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Chemistry of the F-Elements


    We report herein the synthesis and characterization of several imine complexes of tetravalent thorium (Th(IV)) and uranium (U(IV)). The ligands investigated in this study are a Schiff base type, including the well-known salen ligand (H{sub 2}Le, Fig. 1). The complexation in solution was investigated by NMR measurements indicating paramagnetic effects of unpaired f-electrons of U(IV) on the ligand molecule. We also determined the solid-state molecular structures of the synthesized complexes by single crystal X-ray diffraction. The synthesized complexes show an eight-fold coordination geometry around the actinide center surrounded by two tetradentate ligands with 2N- and 2O-donor atoms.

  2. Gen IV Materials Handbook Functionalities and Operation

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Weiju [ORNL


    This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

  3. Research in collegiate mathematics education IV

    CERN Document Server

    Dubinsky, Ed; Kaput, Jim


    This fourth volume of Research in Collegiate Mathematics Education (RCME IV) reflects the themes of student learning and calculus. Included are overviews of calculus reform in France and in the U.S. and large-scale and small-scale longitudinal comparisons of students enrolled in first-year reform courses and in traditional courses. The work continues with detailed studies relating students' understanding of calculus and associated topics. Direct focus is then placed on instruction and student comprehension of courses other than calculus, namely abstract algebra and number theory. The volume co

  4. Reconstruction for Type IV Radial Polydactyly. (United States)

    Wall, Lindley B; Goldfarb, Charles A


    Type IV radial polydactyly represents a thumb with an extra proximal and distal phalanx. Assessment of the thumb for surgical reconstruction includes observing thumb function, evaluating thumb size and stability, and assessing the first web space. Reconstruction includes excision of the smaller thumb, typically the radial thumb, and re-creating thumb stability and alignment by addressing tendon insertion and joint orientation. Although surgical results are satisfying and complications are uncommon, additional surgical intervention may be required over time owing to thumb malalignment or instability. Copyright © 2015 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

  5. New Materials for NGNP/Gen IV

    Energy Technology Data Exchange (ETDEWEB)

    Robert W. Swindeman; Douglas L. Marriott


    The bounding conditions were briefly summarized for the Next Generation Nuclear Plant (NGNP) that is the leading candidate in the Department of Energy Generation IV reactor program. Metallic materials essential to the successful development and proof of concept for the NGNP were identified. The literature bearing on the materials technology for high-temperature gas-cooled reactors was reviewed with emphasis on the needs identified for the NGNP. Several materials were identified for a more thorough study of their databases and behavioral features relative to the requirements ASME Boiler and Pressure Vessel Code, Section III, Division 1, Subsection NH.

  6. Topological characterisation and identification of critical domains within glucosyltransferase IV (GtrIV of Shigella flexneri

    Directory of Open Access Journals (Sweden)

    Nair Anesh


    Full Text Available Abstract Background The three bacteriophage genes gtrA, gtrB and gtr(type are responsible for O-antigen glucosylation in Shigella flexneri. Both gtrA and gtrB have been demonstrated to be highly conserved and interchangeable among serotypes while gtr(type was found to be specific to each serotype, leading to the hypothesis that the Gtr(type proteins are responsible for attaching glucosyl groups to the O-antigen in a site- and serotype- specific manner. Based on the confirmed topologies of GtrI, GtrII and GtrV, such interaction and attachment of the glucosyl groups to the O-antigen has been postulated to occur in the periplasm. Results In this study, the topology of GtrIV was experimentally determined by creating different fusions between GtrIV and a dual-reporter protein, PhoA/LacZ. This study shows that GtrIV consists of 8 transmembrane helices, 2 large periplasmic loops, 2 small cytoplasmic N- and C- terminal ends and a re-entrant loop that occurs between transmembrane helices III and IV. Though this topology differs from that of GtrI, GtrII, GtrV and GtrX, it is very similar to that of GtrIc. Furthermore, both the N-terminal periplasmic and the C-terminal periplasmic loops are important for GtrIV function as shown via a series of loop deletion experiments and the creation of chimeric proteins between GtrIV and its closest structural homologue, GtrIc. Conclusion The current study provides the basis for elucidating the structure and mechanism of action of this important O-antigen modifying glucosyltransferase.

  7. Zirconium(IV) and Hafnium(IV)-Catalyzed Highly Enantioselective Epoxidation of Homoallylic and Bishomoallylic Alcohols (United States)

    Li, Zhi; Yamamoto, Hisashi


    In this report, zirconium(IV) and hafnium(IV)-bishydroxamic acid complexes were utilized in the highly enantioselective epoxidation of homoallylic alcohols and bishomoallylic alcohols, which used to be quite difficult substrates for other types of asymmetric epoxidation reactions. The performance of the catalyst was improved by adding polar additive and molecular sieves. For homoallylic alcohols, the reaction could provide epoxy alcohols in up to 81% yield and up to 98% ee, while for bishomoallylic alcohols, up to 75% yield and 99% ee of epoxy alcohols rather than cyclize compounds could be obtained in most cases. PMID:20481541

  8. Zirconium(IV)- and hafnium(IV)-catalyzed highly enantioselective epoxidation of homoallylic and bishomoallylic alcohols. (United States)

    Li, Zhi; Yamamoto, Hisashi


    In this report, zirconium(IV)- and hafnium(IV)-bishydroxamic acid complexes were utilized in the highly enantioselective epoxidation of homoallylic alcohols and bishomoallylic alcohols, which used to be quite difficult substrates for other types of asymmetric epoxidation reactions. The performance of the catalyst was improved by adding polar additive and molecular sieves. For homoallylic alcohols, the reaction could provide epoxy alcohols in up to 83% yield and up to 98% ee, while, for bishomoallylic alcohols, up to 79% yield and 99% ee of epoxy alcohols rather than cyclized tetrahydrofuran compounds could be obtained in most cases.

  9. Hospitalization Costs for Patients Undergoing Orthopedic Surgery Treated With Intravenous Acetaminophen (IV-APAP) Plus Other IV Analgesics or IV Opioid Monotherapy for Postoperative Pain. (United States)

    Maiese, Brett A; Pham, An T; Shah, Manasee V; Eaddy, Michael T; Lunacsek, Orsolya E; Wan, George J


    To assess the impact on hospitalization costs of multimodal analgesia (MMA), including intravenous acetaminophen (IV-APAP), versus IV opioid monotherapy for postoperative pain management in patients undergoing orthopedic surgery. Utilizing the Truven Health MarketScan(®) Hospital Drug Database (HDD), patients undergoing total knee arthroplasty (TKA), total hip arthroplasty (THA), or surgical repair of hip fracture between 1/1/2011 and 8/31/2014 were separated into postoperative pain management groups: MMA with IV-APAP plus other IV analgesics (IV-APAP group) or an IV opioid monotherapy group. All patients could have received oral analgesics. Baseline characteristics and total hospitalization costs were compared. Additionally, an inverse probability treatment weighting [IPTW] with propensity scores analysis further assessed hospitalization cost differences. The IV-APAP group (n = 33,954) and IV opioid monotherapy group (n = 110,300) differed significantly (P opioid monotherapy group (US$12,540 ± $9564 vs. $13,242 ± $35,825; P opioid monotherapy. This difference was driven by medical costs; importantly, there was no difference in pharmacy costs. Generalizability of the results may be limited to patients admitted to hospitals similar to those included in HDD. Dosing could not be determined, so it was not possible to quantify utilization of IV-APAP or ascertain differences in opioid consumption between the 2 groups. This study did not account for healthcare utilization post-discharge.

  10. After SDSS-IV: Pioneering Panoptic Spectroscopy (United States)

    Kollmeier, Juna; AS4 Collaboration


    I will describe the current plans for a next generation sky survey that will begin After SDSS-IV --- AS4. AS4 will be an unprecedented all-sky spectroscopic survey of over six million objects. It is designed to decode the history of the Milky Way galaxy, trace the emergence of the chemical elements, reveal the inner workings of stars, the growth of black holes, and investigate the origin of planets. It will provide the most comprehensive all-sky spectroscopy to multiply the science from the Gaia, TESS and eROSITA missions. AS4 will also create a contiguous spectroscopic map of the interstellar gas in the Milky Way and nearby galaxies that is 1,000 times larger than the state of the art, uncovering the self-regulation mechanisms of Galactic ecosystems. It will pioneer systematic, spectroscopic monitoring across the whole sky, revealing changes on timescales from 20 minutes to 20 years. The project is now developing new hardware to build on the SDSS-IV infrastructure, designing the detailed survey strategy, and actively seeking to complete its consortium of institutional and individual members.

  11. Creep in generation IV nuclear applications

    Energy Technology Data Exchange (ETDEWEB)

    Rissanen, L. (VTT Technical Research Centre of Finland, Espoo (Finland))


    Nuclear power has an important role in fulfilling the world's growing energy needs and reducing the carbon dioxide emission. Six new, innovative nuclear energy systems have been identified and selected for further development by the international Generation Four International Forum (GIF). These generation four (Gen IV) nuclear energy systems include a variety of reactor, energy conversion and fuel cycle technologies. The successful development and deployment of these largely depend on the performance and reliability of the available structural materials. These potential materials need to sustain their mechanical properties up to high temperatures, high neutron doses and corrosive environments of the new or enhanced types of coolants. Current knowledge on material properties, material-coolant interaction and especially material degradation processes in these new environments are limited. This paper gives an overview of the Gen IV material issues with special emphasis on European design of supercritical light water reactor concept high performance light water reactor (HPLWR). The challenges for the structural materials and the components most likely to suffer from creep and creep-irradiation are highlighted. Some results from relatively short term creep testing in supercritical water are presented for AISI 316NG, 347H and 1.4970 steels. The 1.4970 steel was superior in creep and oxidation resistance (orig.)

  12. Predicting DPP-IV inhibitors with machine learning approaches (United States)

    Cai, Jie; Li, Chanjuan; Liu, Zhihong; Du, Jiewen; Ye, Jiming; Gu, Qiong; Xu, Jun


    Dipeptidyl peptidase IV (DPP-IV) is a promising Type 2 diabetes mellitus (T2DM) drug target. DPP-IV inhibitors prolong the action of glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP), improve glucose homeostasis without weight gain, edema, and hypoglycemia. However, the marketed DPP-IV inhibitors have adverse effects such as nasopharyngitis, headache, nausea, hypersensitivity, skin reactions and pancreatitis. Therefore, it is still expected for novel DPP-IV inhibitors with minimal adverse effects. The scaffolds of existing DPP-IV inhibitors are structurally diversified. This makes it difficult to build virtual screening models based upon the known DPP-IV inhibitor libraries using conventional QSAR approaches. In this paper, we report a new strategy to predict DPP-IV inhibitors with machine learning approaches involving naïve Bayesian (NB) and recursive partitioning (RP) methods. We built 247 machine learning models based on 1307 known DPP-IV inhibitors with optimized molecular properties and topological fingerprints as descriptors. The overall predictive accuracies of the optimized models were greater than 80%. An external test set, composed of 65 recently reported compounds, was employed to validate the optimized models. The results demonstrated that both NB and RP models have a good predictive ability based on different combinations of descriptors. Twenty "good" and twenty "bad" structural fragments for DPP-IV inhibitors can also be derived from these models for inspiring the new DPP-IV inhibitor scaffold design.

  13. Simultaneous expression of 70 kilodalton type IV collagenase and type IV collagen alpha 1 (IV) chain genes by cells of early human placenta and gestational endometrium. (United States)

    Autio-Harmainen, H; Hurskainen, T; Niskasaari, K; Höyhtyä, M; Tryggvason, K


    In this study we used in situ hybridization to investigate the expression of the genes 70 kilodalton (kd) collagenase and the alpha 1(IV) collagen chain of type IV collagen in cells of early human placenta and gestational endometrium. The aim was to study the spatial distribution of these gene expressions within a developing tissue which possesses physiologic invasive potential. The results obtained for the 70 kd type IV collagenase mRNA expression were also compared with the immunohistochemical distribution of the corresponding antigen. Expression of mRNAs for these proteins was found in cells of trophoblastic columns, stromal cells of villi and in cells of decidua and endometrial stroma. The only differences between the expressions was the lower level of signals for 70 kd type IV collagenase in fibroblastic stromal cells and endothelial cells of villi and in the pericytic cells of spiral arteries. Otherwise the results for both types of mRNA were comparable. We also studied the immunohistochemical distribution of the 70 kd type IV collagenase using specific monoclonal antibodies against the enzyme. Immunohistochemistry supported well the findings obtained by in situ hybridization. The results indicate that the genes for the 70 kd type IV collagenase and for the alpha 1(IV) collagen chain are simultaneously active in cells of placenta and gestational endometrium and the same cells which produce type IV collagen also can produce the cleaving enzyme, the 70 kd type IV collagenase. The results also show that the cytotrophoblastic cells, which during early pregnancy invade the extracellular matrix and spiral arteries of uterine wall contain significant amount of mRNA for the 70 kd type IV collagenase. This finding supports the concept that the 70 kd type IV collagenase would be important for invasion, and in the case of this study, also for the physiologic invasion of placental cytotrophoblasts.

  14. Aqueous chemistry of Ce(iv): estimations using actinide analogues. (United States)

    Marsac, Rémi; Réal, Florent; Banik, Nidhu Lal; Pédrot, Mathieu; Pourret, Olivier; Vallet, Valérie


    The prediction of cerium (Ce) aqueous speciation is relevant in many research fields. Indeed, Ce compounds are used for many industrial applications, which may require the control of Ce aqueous chemistry for their synthesis. The aquatic geochemistry of Ce is also of interest. Due to its growing industrial use and its release into the environment, Ce is now considered as an emerging contaminant. Cerium is also used as a proxy of (paleo)redox conditions due to the Ce(iv)/Ce(iii) redox transition. Finally, Ce(iv) is often presented as a relevant analogue of tetravalent actinides (An(iv)). In the present study, quantum chemical calculations were conducted to highlight the similarities between the structures of Ce(iv) and tetravalent actinide (An(iv); An = Th, Pa, U, Np, Pu) aqua-ions, especially Pu(iv). The current knowledge of An(iv) hydrolysis, solubility and colloid formation in water was briefly reviewed but important discrepancies were observed in the available data for Ce(iv). Therefore, new estimations of the hydrolysis constants of Ce(iv) and the solubility of Ce(iv)-(hydr)oxides are proposed, by analogy with Pu(iv). By plotting pH-Eh (Pourbaix) diagrams, we showed that the pH values corresponding to the onset of Ce(iv) species formation (i.e. Ce(iv)-(hydr)oxide or dissolved Ce(iv)) agreed with various experimental results. Although further experimental studies are required to obtain a more accurate thermodynamic database, the present work might yet help to predict more accurately the Ce chemical behavior in aqueous solution.

  15. [The relationships of intelligence and memory assessed using the WAIS-IV and the WMS-IV]. (United States)

    Lepach, A C; Daseking, M; Petermann, F; Waldmann, H C


    This study examines the relationships of intelligence and memory scores derived from WAIS-IV and WMS-IV. We were especially interested in the reciprocal predictive values of the test scales. A sample of 137 healthy adults with an age range between 16 and 69 years was assessed with the WAIS-IV and the WMS-IV. The test order was balanced. Pearson correlations were conducted on the subtest and scale level. A series of 14 linear regression models was tested with memory performance as predictor for intelligence and vice versa. A model including the 3 main memory scales of the WMS-IV was able to predict the global IQ best. It nevertheless explained only 46% of the variance. The memory and intelligence measures show significant relationships, but also represent distinct functions. WAIS-IV and WMS-IV complement one another. © Georg Thieme Verlag KG Stuttgart · New York.

  16. A manganese(IV)/iron(IV) intermediate in assembly of the manganese(IV)/iron(III) cofactor of Chlamydia trachomatis ribonucleotide reductase. (United States)

    Jiang, Wei; Hoffart, Lee M; Krebs, Carsten; Bollinger, J Martin


    We recently showed that the class Ic ribonucleotide reductase from the human pathogen Chlamydia trachomatis uses a Mn(IV)/Fe(III) cofactor to generate protein and substrate radicals in its catalytic mechanism [Jiang, W., Yun, D., Saleh, L., Barr, E. W., Xing, G., Hoffart, L. M., Maslak, M.-A., Krebs, C., and Bollinger, J. M., Jr. (2007) Science 316, 1188-1191]. Here, we have dissected the mechanism of formation of this novel heterobinuclear redox cofactor from the Mn(II)/Fe(II) cluster and O2. An intermediate with a g = 2 EPR signal that shows hyperfine coupling to both 55Mn and 57Fe accumulates almost quantitatively in a second-order reaction between O2 and the reduced R2 complex. The otherwise slow decay of the intermediate to the active Mn(IV)/Fe(III)-R2 complex is accelerated by the presence of the one-electron reductant, ascorbate, implying that the intermediate is more oxidized than Mn(IV)/Fe(III). Mössbauer spectra show that the intermediate contains a high-spin Fe(IV) center. Its chemical and spectroscopic properties establish that the intermediate is a Mn(IV)/Fe(IV)-R2 complex with an S = 1/2 electronic ground state arising from antiferromagnetic coupling between the Mn(IV) (S(Mn) = 3/2) and high-spin Fe(IV) (S(Fe) = 2) sites.

  17. The Design of the IGE Evaluation Project Phase IV Comparative Studies. Comparative Study of Phase IV IGE Evaluation Project. Phase IV, Project Paper 80-2. (United States)

    Romberg, Thomas A.; And Others

    This paper outlines the design of two Comparative Studies of Phase IV of the Individually Guided Education (IGE) Evaluation Project. More than 2,000 elementary schools in 25 states use the IGE system. The Evaluation Project was designed to gain a comprehensive view of the system's operation and effectiveness. Phase IV investigated pupil outcomes,…

  18. Carpentier, la otra novela (cap. IV

    Directory of Open Access Journals (Sweden)

    Urbano Martínez Carmenate


    Full Text Available El presente ensayo está extraído de la obra inédita de Urbano Martínez Carmenate, Carpentier, la otra novela (cap. IV. Ofrece una mirada sobre los primeros años de la trayectoria profesional de Alejo Carpentier. Se muestra cómo, durante la década de 1920, se inicia como periodista y cronista teatral. A la vez, comienzan sus conexiones con el Grupo Minorista, que desempeña un papel destacado en la etapa republicana en Cuba. También se contempla su viaje a México en 1926, que constituye su primer contacto directo con la naturaleza y la cultura americanas.

  19. Carpentier, la otra novela (cap. IV

    Directory of Open Access Journals (Sweden)

    Urbano Martínez Carmenate


    Full Text Available El presente ensayo está extraído de la obra inédita de Urbano Martínez Carmenate, Carpentier, la otra novela (cap. IV. Ofrece una mirada sobre los primeros años de la trayectoria profesional de Alejo Carpentier. Se muestra cómo, durante la década de 1920, se inicia como periodista y cronista teatral. A la vez, comienzan sus conexiones con el Grupo Minorista, que desempeña un papel destacado en la etapa republicana en Cuba. También se contempla su viaje a México en 1926, que constituye su primer contacto directo con la naturaleza y la cultura americanas.

  20. Ultrathin magnetic structures IV applications of nanomagnetism

    CERN Document Server

    Heinrich, Bretislav


    The ability to understand and control the unique properties of interfaces has created an entirely new field of magnetism which already has a profound impact in technology and is providing the basis for a revolution in electronics. The last decade has seen dramatic progress in the development of magnetic devices for information technology but also in the basic understanding of the physics of magnetic nanostructures. Volume III describes thin film magnetic properties and methods for characterising thin film structure topics that underpin the present 'spintronics' revolution in which devices are based on combined magnetic materials and semiconductors. The present volume (IV) deals with the fundamentals of spintronics: magnetoelectronic materials, spin injection and detection, micromagnetics and the development of magnetic random access memory based on GMR and tunnel junction devices. Together these books provide readers with a comprehensive account of an exciting and rapidly developing field. The treatment is de...

  1. A polymeric oxovanadium(IV pyromellitate complex

    Directory of Open Access Journals (Sweden)



    Full Text Available The reaction of oxovanadium(IV sulphate with 1,2,4,5-benzenetetracarboxylic acid (pyromellitic acid in the presence of potassium carbonate yields a polymeric complex, K2[VO(pyr]·6H2O (I [pyr = pyromellitate(4- ion]. The PM3(tm calculations and IR spectroscopy suggest that the polymeric structure of I consists of -V-pyr-V-pyr- chains formed by the 1,4- or 1,5-bridging by the pyr ions. The chains are additionally cross-linked by the chelate function of one of the COO- groups of the pyr ion. Magnetic measurements do not reveal the presence of antiferromagnetic coupling between the V centers.

  2. Classification of amok in DSM-IV. (United States)

    Gaw, A C; Bernstein, R L


    Culture-bound syndromes have been described worldwide in many individuals and, for certain syndromes, in epidemic proportion, yet these disorders have been classified as rare and exotic conditions warranting minimal attention. Development of the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders and the tenth edition of the International Classification of Diseases offers an opportunity for providing a more sophisticated classification of these phenomena. The authors examine amok, a syndrome first described in Malaysia that consists of homicidal frenzy preceded by a state of brooding and ending with somnolence and amnesia. They discuss the concept of and criteria for a culture-specific disorder and propose that amok be classified as a culture-specific explosive behavioral disorder in DSM-IV.

  3. Review of the BCI Competition IV (United States)

    Tangermann, Michael; Müller, Klaus-Robert; Aertsen, Ad; Birbaumer, Niels; Braun, Christoph; Brunner, Clemens; Leeb, Robert; Mehring, Carsten; Miller, Kai J.; Müller-Putz, Gernot R.; Nolte, Guido; Pfurtscheller, Gert; Preissl, Hubert; Schalk, Gerwin; Schlögl, Alois; Vidaurre, Carmen; Waldert, Stephan; Blankertz, Benjamin


    The BCI competition IV stands in the tradition of prior BCI competitions that aim to provide high quality neuroscientific data for open access to the scientific community. As experienced already in prior competitions not only scientists from the narrow field of BCI compete, but scholars with a broad variety of backgrounds and nationalities. They include high specialists as well as students. The goals of all BCI competitions have always been to challenge with respect to novel paradigms and complex data. We report on the following challenges: (1) asynchronous data, (2) synthetic, (3) multi-class continuous data, (4) session-to-session transfer, (5) directionally modulated MEG, (6) finger movements recorded by ECoG. As after past competitions, our hope is that winning entries may enhance the analysis methods of future BCIs. PMID:22811657



    Ramírez, Luis Miguel


    Los dias 4,5 y 6 de septiembre de 2008 tendrá lugar el IV Congreso Nacional de Morfologíaen la ciudad de Manizales con la participación de reconocidos profesores, médicos y doctores,quienes expondrán temas de mucha actualidad, relacionados con la morfología macroscópica ymicroscópica.Los trabajos serán originales o meta-análisis y tendrán dos modalidades de presentación:simposio o póster y los contenidos abarcarán asuntos de anatomia macroscópica, histologia,Embriologia, neuroanatomia, enseña...

  5. Characterization of a Grape Class IV Chitinase (United States)


    A chitinase was purified from Vitis vinifera Manzoni Bianco grape juice and characterized. On the basis of proteomic analysis of tryptic peptides, a significant match identified the enzyme as a type IV grape chitinase previously found in juices of other V. vinifera varieties. The optimal pH and temperature for activity toward colloidal chitin were found to be 6 and 30 °C, respectively. The enzyme was found to hydrolyze chitin and oligomers of N-acetylglucosamine, generating N,N′-diacetylchitobiose and N-acetylglucosamine as products, but was inactive toward N,N′-diacetylchitobiose. The enzyme exhibited both endo- and exochitinase activities. Because yeast contains a small amount of chitin in the cell wall, the possibility of growth inhibition was tested. At a concentration and pH expected in ripe grapes, no inhibition of wine yeast growth by the chitinase was observed. PMID:24845689

  6. Redécouverte à Lille d’un décor peint à fresque par Victor-Louis Mottez : un jalon important dans la peinture décorative du XIXe siècle et du « premier XXe siècle »


    Guillot, Catherine


    Considéré depuis les années 1930 comme disparu, un décor peint à fresque de Victor Mottez (1809-1897), datant des années 1865, a été récemment mis au jour dans une maison lilloise. Il a fait l’objet en 2011 d’une protection au titre des monuments historiques. Il s’agit d’un des rares décors profanes réalisés par l’artiste. Malgré un état de conservation lacunaire, cette découverte éclaire d’un jour nouveau l’œuvre de Mottez, contrebalançant ses réalisations plus connues pour des édifices reli...

  7. Reviews Book: Nucleus Book: The Wonderful World of Relativity Book: Head Shot Book: Cosmos Close-Up Places to Visit: Physics DemoLab Book: Quarks, Leptons and the Big Bang EBook: Shooting Stars Equipment: Victor 70C USB Digital Multimeter Web Watch (United States)


    WE RECOMMEND Nucleus: A Trip into the Heart of Matter A coffee-table book for everyone to dip into and learn from The Wonderful World of Relativity A charming, stand-out introduction to relativity The Physics DemoLab, National University of Singapore A treasure trove of physics for hands-on science experiences Quarks, Leptons and the Big Bang Perfect to polish up on particle physics for older students Victor 70C USB Digital Multimeter Equipment impresses for usability and value WORTH A LOOK Cosmos Close-Up Weighty tour of the galaxy that would make a good display Shooting Stars Encourage students to try astrophotography with this ebook HANDLE WITH CARE Head Shot: The Science Behind the JKF Assassination Exploration of the science behind the crime fails to impress WEB WATCH App-lied science for education: a selection of free Android apps are reviewed and iPhone app options are listed

  8. Immunohistochemical investigation of alpha1 (IV) and alpha5 (IV) collagen chains in a broad spectrum of melanocytic tumours. (United States)

    Quatresooz, Pascale; Piérard, Gérald E


    Cells of melanocytic naevi and cutaneous malignant melanomas (MM) are surrounded by a basement membrane (BM). To scrutinize any difference between the deposits of alpha1 (IV) and alpha5 (IV) collagen chains in melanocytic naevi and MM. A total of 27 common melanocytic naevi, 11 dysplastic naevi, 21 atypical naevi (melanocytomas) including Spitz and non-Spitz types, as well as 24 MM were studied. Their phenotypic and functional characteristics defined by immunohistochemistry using a panel of antibodies, including those directed to the alpha1 (IV), alpha3 (IV) and alpha5 (IV) collagen chains. Almost all naevi and half the melanocytomas exhibited a strong positivity for the alpha1 (IV) collagen chain. By contrast, the remaining melanocytomas and MM presented a heterogeneous staining pattern for the alpha1 (IV) collagen chain. One third of the naevi, 23% of the MM without cutaneous micrometastasis and 83% of MM with cutaneous micrometastasis showed discrete cytoplasmic positivity for the alpha5 (IV) collagen chain. All other melanocytic tumours were negative for this antibody. Rare MM cells in transepidermal migration were stained with the anti-alpha1 (IV) or alpha5 (IV) collagen chain antibodies. No immunoreactivity for the alpha3 (IV) collagen chain was disclosed in any of the samples. We report the expression of alpha1 (IV) and alpha5 (IV) collagen chains in naevi and MM. The inconsistent staining pattern for alpha1 (IV) collagen chain in phenotypically atypical melanocytomas and in MM highlight the heterogeneity in both cell differentiation and stroma-tumour interactions. This biological aspect may be related to neoplastic progression and influence metastatic potential.

  9. Overoxidation of phenol by hexachloroiridate(IV). (United States)

    Song, Na; Stanbury, David M


    It has been previously established that the aqueous oxidation of phenol by a deficiency of [IrCl(6)](2-) proceeds through the production of [IrCl(6)](3-) and phenoxyl radicals. Coupling of the phenoxyl radicals leads primarily to 4,4'-biphenol, 2,2'-biphenol, 2,4'-biphenol, and 4-phenoxyphenol. Overoxidation occurs through the further oxidation of these coupling products, leading to a rather complex mixture of final products. The rate laws for oxidation of the four coupling products by [IrCl(6)](2-) have the same form as those for the oxidation of phenol itself: -d[Ir(IV)]/dt = {(k(ArOH) + k(ArO(-))K(a)/[H(+)])/(1 + K(a)/[H(+)])}[ArOH](tot)[Ir(IV)]. Values for k(ArOH) and k(ArO(-)) have been determined for the four substrates at 25 °C and are assigned to H(2)O-PCET and electron-transfer mechanisms, respectively. Kinetic simulations of a combined mechanism that includes the rate of oxidation of phenol as well as the rates of these overoxidation steps show that the degree of overoxidation is rather limited at high pH but quite extensive at low pH. This pH-dependent overoxidation leads to a pH-dependent stoichiometric factor in the rate law for oxidation of phenol and causes some minor deviations in the rate law for oxidation of phenol. Empirically, these minor deviations can be accommodated by the introduction of a third term in the rate law that includes a "pH-dependent rate constant", but this approach masks the mechanistic origins of the effect. © 2011 American Chemical Society

  10. Pembuatan Aplikasi Salesforce Automation System Pada Toko IV Berbasis Android


    Soenaryo, Soen, Surya; Yulia, Yulia; Palit, Henry Novianus


    Currently, the information system that was recently implemented in IV shop worked well in the long term for administration purpose. Meanwhile, IV shop still lacks any supporting application for their front-end sales department, which has direct contact with customer in daily basis.The fact that IV shop sells various car-related products with various brands troubles their salespeople because they have to learn and understand each product's uniqueness. In addition, occasionally, there are commu...

  11. BALTICA IV. Plant maintenance for managing life and performance

    Energy Technology Data Exchange (ETDEWEB)

    Hietanen, S.; Auerkari, P. [eds.] [VTT Manufacturing Technology, Espoo (Finland). Operational Reliability


    BALTICA IV International Conference on Plant Maintenance Managing Life and performance held on September 7-9, 1998 on board M/S Silja Symphony on its cruise between Helsinki-Stockholm and at Aavaranta in Kirkkonummi. The BALTICA IV conference provides a forum for the transfer of technology from applied research to practice. This is one of the two volumes of the proceedings of the BALTICA IV International Conference on Plant Maintenance Managing Life and Performance. The BALTICA IV conference focuses on new technology, recent experience and applications of condition and life management, and on improvements in maintenance strategies for safe and economical operation of power plants. (orig.)

  12. Apolipoprotein A-IV: a protein intimately involved in metabolism


    Wang, Fei; Kohan, Alison B.; Lo, Chun-Min; Liu, Min; Howles, Philip; Tso, Patrick


    The purpose of this review is to summarize our current understanding of the physiological roles of apoA-IV in metabolism, and to underscore the potential for apoA-IV to be a focus for new therapies aimed at the treatment of diabetes and obesity-related disorders. ApoA-IV is primarily synthesized by the small intestine, attached to chylomicrons by enterocytes, and secreted into intestinal lymph during fat absorption. In circulation, apoA-IV is associated with HDL and chylomicron remnants, but ...

  13. 1L Mark-IV Target Design Review

    Energy Technology Data Exchange (ETDEWEB)

    Koehler, Paul E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)


    This presentation includes General Design Considerations; Current (Mark-III) Lower Tier; Mark-III Upper Tier; Performance Metrics; General Improvements for Material Science; General Improvements for Nuclear Science; Improving FOM for Nuclear Science; General Design Considerations Summary; Design Optimization Studies; Expected Mark-IV Performance: Material Science; Expected Mark-IV Performance: Nuclear Science (Disk); Mark IV Enables Much Wider Range of Nuclear-Science FOM Gains than Mark III; Mark-IV Performance Summary; Rod or Disk? Center or Real FOV?; and Project Cost and Schedule.

  14. Toward Phase IV, Populating the WOVOdat Database (United States)

    Ratdomopurbo, A.; Newhall, C. G.; Schwandner, F. M.; Selva, J.; Ueda, H.


    One of challenges for volcanologists is the fact that more and more people are likely to live on volcanic slopes. Information about volcanic activity during unrest should be accurate and rapidly distributed. As unrest may lead to eruption, evacuation may be necessary to minimize damage and casualties. The decision to evacuate people is usually based on the interpretation of monitoring data. Over the past several decades, monitoring volcanoes has used more and more sophisticated instruments. A huge volume of data is collected in order to understand the state of activity and behaviour of a volcano. WOVOdat, The World Organization of Volcano Observatories (WOVO) Database of Volcanic Unrest, will provide context within which scientists can interpret the state of their own volcano, during and between crises. After a decision during the 2000 IAVCEI General Assembly to create WOVOdat, development has passed through several phases, from Concept Development (Phase-I in 2000-2002), Database Design (Phase-II, 2003-2006) and Pilot Testing (Phase-III in 2007-2008). For WOVOdat to be operational, there are still two (2) steps to complete, which are: Database Population (Phase-IV) and Enhancement and Maintenance (Phase-V). Since January 2009, the WOVOdat project is hosted by Earth Observatory of Singapore for at least a 5-year period. According to the original planning in 2002, this 5-year period will be used for completing the Phase-IV. As the WOVOdat design is not yet tested for all types of data, 2009 is still reserved for building the back-end relational database management system (RDBMS) of WOVOdat and testing it with more complex data. Fine-tuning of the WOVOdat’s RDBMS design is being done with each new upload of observatory data. The next and main phase of WOVOdat development will be data population, managing data transfer from multiple observatory formats to WOVOdat format. Data population will depend on two important things, the availability of SQL database in volcano

  15. Selective Stripping of Zr (IV) over Hf (IV) in Loaded D2EHPA Extracted from Strong Sulfuric Acid Solutions

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Ling Yun; Lee, Man Seung [Mokpo National University, Mokpo (Korea, Republic of)


    To develop a process for the selective extraction of Hf (IV) over Zr (IV) from a strong sulfuric acid solution, we investigated the stripping of Zr (IV) and Hf (IV) from loaded D2EHPA using alkaline reagents and various acid solutions. Since both Zr (IV) and Hf (IV) were quantitatively stripped by oxalic acid as well as by alkaline reagents (Na{sub 2}CO{sub 3} and (NH{sub 4}){sub 2}CO{sub 3}), it was difficult to separate the two metals during the stripping step. Among the tested inorganic acids (HCl, HNO{sub 3} and H{sub 2}SO{sub 4}), only sulfuric acid could strip Zr (IV) and Hf (IV) and the stripping behavior was dependent on the sulfuric acid concentration employed in the extraction. When the extraction of the two metals by D2EHPA was conducted with a 0.5 M sulfuric acid solution, Zr (IV) was selectively stripped from the loaded D2EPA with a sulfuric acid solution of 3-5 M. A separation factor of 10 resulted from the stripping with a 4 M sulfuric acid solution.

  16. 1. IV toimus Kõrvekülas... / Hele Ellermaa

    Index Scriptorium Estoniae

    Ellermaa, Hele


    Toimus Hans Christian Anderseni 200. sünniaastapäevale ja rahvusvahelisele lasteraamatupäevale pühendatud IV Tartumaa lasteraamatupäev. Konkursile laekus 172 joonistust, 14 kirjatööd ja 73 paberlõikepilti. Laste tööde näitus on avatud Kõrveküla raamatukogus kuni 16. IV

  17. On the Bivariate Kummer-Beta Type IV Distribution

    NARCIS (Netherlands)

    Jacobs, R.; Bekker, A.; Human, S.W.


    In this article, the non central bivariate Kummer-beta Type IV distribution is introduced and derived via the Laplace transform of the non central bivariate beta distribution by Gupta et al. (2011 ). We focus on and discuss the central bivariate Kummer-beta Type IV distribution; this distribution is

  18. 76 FR 36095 - Defense Transportation Regulation, Part IV (United States)


    ... be found on the Defense Transportation Regulation, Part IV Web site at into the Defense Transportation Regulation (DTR) Part IV (DTR 4500.9R). These program requirements do... have an economic impact of $100 million or more. A complete version of the DTR is available via the...

  19. 75 FR 70217 - Defense Transportation Regulation, Part IV (United States)


    ... on the USTRANSCOM Web site (under misc) at . Additional... Register Announcement and incorporated into the Defense Transportation Regulation (DTR) Part IV (DTR 4500... complete version of the DTR is available via the Internet on the USTRANSCOM homepage at http://www.transcom...

  20. Hepatocellular carcinoma in glycogen storage disease type IV


    de Moor, R A; Schweizer, J.; Van Hoek, B.; Wasser, M.; Vink, R.; Maaswinkel-Mooy, P.


    A 13 year old patient with juvenile type IV glycogen storage disease died of the complications of hepatocellular carcinoma. To our knowledge this is the first reported case of hepatocellular carcinoma in association with type IV glycogen storage disease.

  1. Beyond the DSM-IV: Assumptions, Alternatives, and Alterations (United States)

    Lopez, Shane J.; Edwards, Lisa M.; Pedrotti, Jennifer Teramoto; Prosser, Ellie C.; LaRue, Stephanie; Spalitto, Susan Vehige; Ulven, Jon C.


    Current diagnostic processes reflect the limitations and utility of the framework of the "Diagnostic and Statistical Manual of Mental Disorders" (4th ed.; DSM-IV; American Psychiatric Association, 1994). Clinical information in the DSM-IV's 5-axis system almost exclusively focuses on weaknesses and pathology and is summarized in a flawed…

  2. Equilibrium between Different Coordination Geometries in Oxidovanadium(IV) Complexes (United States)

    Ugone, Valeria; Garribba, Eugenio; Micera, Giovanni; Sanna, Daniele


    In this laboratory activity, the equilibrium between square pyramidal and octahedral V(IV)O[superscript 2+] complexes is described. We propose a set of experiments to synthesize and characterize two types of V(IV)O[superscript 2+] complexes. The experiment allows great flexibility and may be effectively used at a variety of levels and the activity…

  3. Generation IV: new reactor systems; Neue Reaktorsysteme innerhalb der Generation IV Initiative

    Energy Technology Data Exchange (ETDEWEB)

    Starflinger, J.; Schulenberg, T. [Forschungszentrum Karlsruhe GmbH Technik und Umwelt (Germany). IKET; Hofmeister, J. [RWE Power AG, Regenerative Stromerzeugung, Essen (Germany); Tromm, W. [Forschungszentrum Karlsruhe GmbH Technik und Umwelt (Germany). Programm Nukleare Sicherheitsforschung


    Generation IV, an initiative for international cooperation in nuclear technology, was launched by 10 states in 2000 and joined by Euratom in July 2003. Its aim is to assess nuclear energy systems complying with future safety, disposal, proliferation, and public acceptance requirements. The Forschungszentrum Karlsruhe focuses on design, thermohydraulics, and neutron kinetics. Work is mainly devoted to the high-performance light water reactor (HPLWR) with supercritical steam conditions. Thus, competence can be maintained, as the HPLWR issues qualify for later work in nuclear industry. (orig.)

  4. Crystal structure of ammonium divanadium(IV,V tellurium(IV heptaoxide

    Directory of Open Access Journals (Sweden)

    William T. A. Harrison


    Full Text Available The polyhedral building blocks of the layered inorganic network in the mixed-valence title compound, (NH4(VIVO2(VVO2(TeO3, are vertex-sharing VVO4 tetrahedra, distorted VIVO6 octahedra and TeO3 pyramids, which are linked by V—O—V and V—O—Te bonds, forming double layers lying parallel to (100. The presumed TeIV lone-pairs of electrons appear to be directed inwards into cavities in the double layers. The charge-balancing ammonium cations lie between the layers and probably interact with them via N—H...O hydrogen bonds.

  5. Bifidobacteria possess inhibitory activity against dipeptidyl peptidase-IV. (United States)

    Zeng, Z; Luo, J Y; Zuo, F L; Yu, R; Zhang, Y; Ma, H Q; Chen, S W


    The incretin hormones are extremely rapidly metabolized by the ubiquitous enzyme dipeptidyl peptidase IV (DPP-IV). Therefore, DPP-IV inhibitors which can prolong the incretin effect are the newest and promising drugs for management of type 2 diabetes. In this study, we investigated whether Bifidobacteria colonizing the human gut possess DPP-IV inhibitory activity. Cell-free intracellular extracts of 13 Bifidobacterium strains isolated from breast-fed infant faecal samples were prepared and screened for DPP-IV inhibitory activity, and two Bifidobacterium strains-Bif. longum BBMN68 and Bif. lactis Bb12-were used as reference strains. Most of the strains showed varying levels of DPP-IV inhibitory property (7-27%). Strains of Bifidobacterium adolescentis IF1-11 and Bifidobacterium bifidum IF3-211 showed the greatest DPP-IV inhibitory activity (27 and 25%) as well as good in vitro probiotic properties. This initial finding suggested that new beneficial function of Bifidobacteria is strain-dependent and the strains or their components may have the potential application for management of type 2 diabetes via inhibiting gastrointestinal DPP-IV activity. Further investigations into the isolation and identification of the bioactive components of Bifidobacteria are warranted. Our results show that Bifidobacteria isolated from breast-fed infants' faecal samples possess DPP-IV inhibitory activity. Strains of Bifidobacterium bifidum IF3-211 and Bifidobacterium adolescentis IF1-11, which showed excellent DPP-IV inhibitory properties as well as good in vitro probiotic properties, are expected to be beneficial for application as anti-diabetic probiotics. © 2015 The Society for Applied Microbiology.

  6. Actinide Corroles: Synthesis and Characterization of Thorium(IV) and Uranium(IV) bis(-chloride) Dimers

    Energy Technology Data Exchange (ETDEWEB)

    Ward, Ashleigh L.; Buckley, Heather L.; Gryko, Daniel T.; Lukens, Wayne W.; Arnold, John


    The first synthesis and structural characterization of actinide corroles is presented. Thorium(IV) and uranium(IV) macrocycles of Mes2(p-OMePh)corrole were synthesised and characterized by single-crystal X-ray diffraction, UV-Visible spectroscopy, variable-temperature 1H NMR, ESI mass spectrometry and cyclic voltammetry.

  7. [Addictive behaviours from DSM-IV to DSM-5]. (United States)

    van den Brink, W


    The 5th edition of the DSM was published in May, 2013. The new edition incorporates important changes in the classification of addiction. To compare the classification of addictive behaviours presented in DSM-IV with the classification presented in DSM-5 and to comment on the changes introduced into the new version. First of all, the historical developments of the concept of addiction and the classification of addictive behaviours up to DSM-IV are summarised. Then the changes that have been incorporated into DSM-5 are described. The main changes are: (1) DSM-IV substance related disorders and DSM-IV pathological gambling have been combined into one new DSM-5 category, namely 'Substance Related and Addictive Disorders'; (2) DSM-IV abuse and dependence have been combined into one new DSM-5 diagnosis, namely 'Substance Use Disorder'; (2a) the DSM-IV abuse criterion 'recurrent substance-related legal problems' and the DSM-5 criterion 'craving' has been introduced; and (2b) the criteria for (partial) remission have been sharpened. DSM-5 is an improvement on DSM-IV, but for the diagnosis of a psychiatric disorder and the treatment of a psychiatric patient, classification needs to be complemented with staging and profiling.

  8. Complexity and the Idea of Human Development | Hurst | South ...

    African Journals Online (AJOL)

    I agree with Cilliers that deconstruction is exemplary in this respect, but aim to broaden the adventure by suggesting ideas for a 'pragmatics of complexity' involving vocabulary, concepts, strategies, metaphors, and heuristics derived also from other philosophers and psychoanalytic theorists. The difficulty of complex thought ...

  9. Derrida's Quasi-Transcendental Thinking | Hurst | South African ...

    African Journals Online (AJOL)

    either/or” choice between the poles of this duality, precisely because these alternatives stand in a relation, not of analytical contradiction, but of aporia, or dilemma. If this exposition proves to be too abstruse and metaphysical for some, a second, ...

  10. Genetic Aspects of Epilepsy | Hurst | South African Medical Journal

    African Journals Online (AJOL)

    Continental, American and South African studies point to a single gene mechanism in epilepsy, carrying with it the hope of chemical cure. Behavioural features should determine the advisability of marriage, rather than genetic considerations, in view of the low penetrance of the gene. S. Afr. Med. J., 48, 603 (1974) ...

  11. Obituary: Ernest Hurst Cherrington, Jr., 1909-1996 (United States)

    Osterbrock, Donald E.


    Ernest H. Cherrington, Jr., a long-time member of the AAS, died in San Jose, California on 13 July 1996, following a long illness. He had a short but active career as a research astronomer at Perkins Observatory at Ohio Wesleyan University in Delaware, Ohio before World War II, in which he served as an officer in the Army Air Force. After the war ended he turned to full-time teaching and administration at the University of Akron, and then at Hood College in Frederick, Maryland. Ernest was born on 10 September 1909 in Westerville, Ohio, where his father, Ernest H. Cherrington, Sr., was a leader in the temperance movement and publisher of "American Issue", a Prohibitionist magazine. Ernest Jr.'s mother, Betty Clifford (née Denny) Cherrington, was a homemaker. He was an outstanding student in high school and at Ohio Wesleyan University, which he entered in 1927. The little university's Perkins Observatory with its 69-inch reflector, briefly the second largest telescope in the United States, had just been built and gone into operation. After graduating with a BA magna cum laude in astronomy in 1931, Ernest stayed on one more year and earned his MS with a thesis on the motion of material in the tail of Comet Morehouse, supervised by Nicholas T. Bobrovnikoff. In 1932 Ernest entered the University of California at Berkeley as a graduate student, with a one-year teaching assistantship in the Astronomical Department. This was followed by a two-year Lick Observatory Fellowship. In June 1933 he married Ann McAfee Naylor, who had been a classmate at Delaware High School and Ohio Wesleyan. Ernest did his PhD thesis on spectrophotometry of the Mg I b lines in the solar spectrum, using a high-resolution grating spectrograph on the Berkeley campus, designed by C. Donald Shane, his adviser. In this thesis, Ernest tested and improved the then current theory of strong absorption lines in stellar atmospheres. He also spent several short periods at Lick Observatory on Mount Hamilton, working in stellar spectroscopy with Joseph H. Moore. After earning his PhD in 1935, Ernest taught mathematics and astronomy for one year at Syracuse University, and then in 1936 returned to Ohio Wesleyan as an assistant astronomer and instructor in physics and astronomy. In 1940 he was promoted to assistant professor. He did good spectroscopic research on Be stars, especially a long study of the variations in the spectrum of γ Cas, an unusually active star of this class which he followed as it threw off several shells. It was a program well suited to the telescope, spectrograph, and site available to him. Ernest attended several meetings of the AAS, reported on his research in oral papers, and published them. However after America entered World War II he went into the Army Air Force in 1942, serving as a Captain in the Air Force Training Command. He had an important job directing ground training of officers, cadets, and enlisted men at various fields in California and New Mexico. After the war, although he could have returned to Perkins Observatory, he realized that the future was not hopeful for astronomical research there, and decided to switch to academic administration. He was at Centenary College, Louisiana for two years, 1946--48, and then went to the University of Akron as professor of astronomy and dean of the College of Liberal Arts from 1948 to 1960, then of its Graduate Division from 1960 to 1967. He loved teaching astronomy and continued to do so while holding these deanships. Ernest was a good writer, and he published several articles on astronomy and science in the "New York Times Sunday Magazine" and other mass-circulation magazines in those years. Ernest retired at Akron in 1967 but moved to Hood College in Frederick, Maryland, as professor of astronomy, a full-time teaching position with no administrative duties. Soon after arriving there he published "Exploring the Moon with Binoculars", a very popular book in the early days of the NASA program of lunar photography from unmanned space vehicles. All the ground-based photographs in his book came from Lick Observatory, most of them taken by Moore and Fred Chappell, with whom he had worked. About 1979 he retired from Hood College and he and his wife moved to San Jose, near the home of their surviving son, Robert N. Cherrington. Ernest was always a good family man, devoted to his wife and children. I met Ernest at his home in San Jose and interviewed him several times in preparation for the Lick centennial in 1988; he had warm memories of Lick and the Berkeley Astronomical Department. In 1984 he had updated his book to "Exploring the Moon through Binoculars and Small Telescopes", with additional photographs from lunar orbiting vehicles and one taken by Neil Armstrong of Buzz Aldrin on the moon's surface. Ernest's wife Ann died in 1988 and he followed her eight years later. There are about one hundred letters to, from, or about Ernest, written in the years 1931 to 1948, in the Mary Lea Shane Archives of the Lick Observatory, McHenry Library, University of California. These letters, his published papers and book, and Perkins Observatory annual reports, together with information provided by Robert N. Cherrington and my own notes and memories of conversations with Ernest and Ann formed the basis of this obituary article.

  12. [Characteristics of MT-IV in sheep and goat]. (United States)

    Wang, Jia; Zhang, Li-Ping; Yang, Lian; Fei, Chun-Hong; Wang, Lei; Xie, Chao; Wu, Jian-Ping


    Metallothioneins (MTs) was characterized by its low molecular weight (6 to 7 kDa), high metal content, high content of conserved cysteine(Cys) residues and absence of aromatic amino acids. In mammals there are four isoforms (MT-I-IV), MT-IV was expressed exclusively in stratified squamous epithelia. In this study, according to other animal MT-IV gene sequence from GenBank, a pair of special primers (MT-IVSP1 and MT-IVSP2) were designed for cloning the coding sequence of MT-IV from rumen organ in both sheep and goat. The MT-IV coding sequence in goat and sheep were 189bp, and be submitted to GenBank under Accession Numbers EF470251 and EF624067, respectively. Both goat and sheep MT-IV gene coded 62 AAs, including 20 Cys residues in sheep, 19 Cys residues in goat, the 61st conserved Cys was replaced by Trp in goat. MT-IV in goat and sheep both have characteristic Cys-x-Cys, Cys-x-y-Cys, and Cys-Cys sequences of MTs , where x and y were non-cysteine amino acids, no aromatic AAs, no cross membrane area, and no signal peptide, these information showed MT-IV in goat and sheep was a cytoplasmic protein. The second structure of MT-IV was coil, except sheet structure in 7-9 AAs and 49-51AAs. The 3 dimension structure was composed by a-and b-domain, the beta-domain structure was same between sheep and goat, and same with other species, but a- domain structure in goat was difference with sheep and other species, because it less one Cys in goat than other animals,the structure change maybe alter the biological function, it is necessary to study further.

  13. Dissimilatory Fe(III) and Mn(IV) reduction. (United States)

    Lovley, D R


    The oxidation of organic matter coupled to the reduction of Fe(III) or Mn(IV) is one of the most important biogeochemical reactions in aquatic sediments, soils, and groundwater. This process, which may have been the first globally significant mechanism for the oxidation of organic matter to carbon dioxide, plays an important role in the oxidation of natural and contaminant organic compounds in a variety of environments and contributes to other phenomena of widespread significance such as the release of metals and nutrients into water supplies, the magnetization of sediments, and the corrosion of metal. Until recently, much of the Fe(III) and Mn(IV) reduction in sedimentary environments was considered to be the result of nonenzymatic processes. However, microorganisms which can effectively couple the oxidation of organic compounds to the reduction of Fe(III) or Mn(IV) have recently been discovered. With Fe(III) or Mn(IV) as the sole electron acceptor, these organisms can completely oxidize fatty acids, hydrogen, or a variety of monoaromatic compounds. This metabolism provides energy to support growth. Sugars and amino acids can be completely oxidized by the cooperative activity of fermentative microorganisms and hydrogen- and fatty-acid-oxidizing Fe(III) and Mn(IV) reducers. This provides a microbial mechanism for the oxidation of the complex assemblage of sedimentary organic matter in Fe(III)- or Mn(IV)-reducing environments. The available evidence indicates that this enzymatic reduction of Fe(III) or Mn(IV) accounts for most of the oxidation of organic matter coupled to reduction of Fe(III) and Mn(IV) in sedimentary environments. Little is known about the diversity and ecology of the microorganisms responsible for Fe(III) and Mn(IV) reduction, and only preliminary studies have been conducted on the physiology and biochemistry of this process.

  14. Cognitive-behavioral interventions for IV insertion pain. (United States)

    Jacobson, Ann F


    INSERTION OF AN IV CATHETER is a commonly performed and painful procedure. The use of cognitive-behavioral interventions (CBIs) may decrease pain by diverting the patient's attention to stimuli other than pain. THIS RANDOMIZED, CONTROLLED TRIAL examined the effect of three CBIs--music, kaleidoscope, and guided imagery--on IV insertion pain in 324 patients. NO STATISTICALLY SIGNIFICANT differences in IV insertion pain were found among the treatment and control groups or between choosing versus being assigned a CBI. Insertion attempts were more difficult in women, and insertion difficulty was correlated with pain intensity and pain distress. Pain intensity was related to insertion site and catheter gauge.

  15. A case of hereditary sensory autonomic neuropathy type IV

    Directory of Open Access Journals (Sweden)

    G P Prashanth


    Full Text Available Hereditary sensory autonomic neuropathy type IV (HSAN -IV, also known as congenital insensitivity to pain with anhidrosis, is a very rare condition that presents in infancy with anhidrosis, absence of pain sensation and self -mutilation. Developmental delay and mental retardation are usually present. Ultrastructural study of the peripheral nerves demonstrates loss of the unmyelinated and small myelinated fibers. We here report a 8 year -old boy with HSAN IV with typical clinical features where the diagnosis was supported by nerve biopsy findings. However, our case was unusual since mental development was normal.

  16. U(IV) fluorescence spectroscopy. A new speciation tool

    Energy Technology Data Exchange (ETDEWEB)

    Lehmann, Susanne; Brendler, Vinzenz [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Surface Processes; Steudtner, Robin [Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany). Inst. of Resource Ecology


    We combined absorption and fluorescence spectroscopy to study the speciation of U(IV) in solution in concentrations down to 10{sup -6} M uranium. With our time-resolved laser-induced fluorescence setup we could determine the fluorescence decay time of U(IV) in perchloric as well as in chloric acid with 2.6 ± 0.3 ns at room temperature and 148.4 ± 6.5 ns at liquid nitrogen temperature. For the U(IV) sulfate system, we observed a bathochromic shift and a peak shape modification in the fluorescence spectra with increasing sulfate concentration in solution. Thus, the potential of U(IV) fluorescence for speciation analysis could be proven.

  17. Phase IV Land Disposal Restrictions Rule - Clarification of Effective Dates (United States)

    Memo to clarify the effective dates for the major provisions of the Phase IV rule. It is supplemental to the final rule preamble at page 28556 (“Effective Dates”) and pages 28634-5 (“State Authority”).

  18. Genetics Home Reference: glycogen storage disease type IV (United States)

    ... hepatic type of GSD IV often die of liver failure in early childhood. The non-progressive hepatic type ... and Advocacy Resources (7 links) American Heart Association: Pediatric Cardiomyopathies American Liver Foundation Association for Glycogen Storage Disease CLIMB: Children ...

  19. Complexation of Plutonium (IV) With Sulfate At Variable Temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Y. Xia; J.I. Friese; D.A> Moore; P.P. Bachelor; L. Rao


    The complexation of plutonium(IV) with sulfate at variable temperatures has been investigated by solvent extraction method. A NaBrO{sub 3} solution was used as holding oxidant to maintain the plutonium(IV) oxidation state throughout the experiments. The distribution ratio of Pu(IV) between the organic and aqueous phases was found to decrease as the concentrations of sulfate were increased. Stability constants of the 1:1 and 1:2 Pu(IV)-HSO{sub 4}{sup -} complexes, dominant in the aqueous phase, were calculated from the effect of [HSO{sub 4}{sup -}] on the distribution ratio. The enthalpy and entropy of complexation were calculated from the stability constants at different temperatures using the Van't Hoff equation.

  20. Errors Associated with IV Infusions in Critical Care

    National Research Council Canada - National Science Library

    Summa-Sorgini, Claudia; Fernandes, Virginia; Lubchansky, Stephanie; Mehta, Sangeeta; Hallett, David; Bailie, Toni; Lapinsky, Stephen E; Burry, Lisa


    ...% of medication errors. To determine the type and frequency of errors associated with prescribing, documenting, and administering IV infusions, and to also determine if a correlation exists between the incidence of errors...

  1. Nordic Nuclear Materials Forum for Generation IV Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Anghel, C. (Studsvik Nuclear AB, Nykoeping (Sweden)); Penttilae, S. (Technical Research Centre of Finland, VTT (Finland))


    A network for material issues for Generation IV nuclear power has been initiated within the Nordic countries. The objectives of the Generation IV Nordic Nuclear Materials Forum (NOMAGE4) are to put the basis of a sustainable forum for Gen IV issues, especially focussing on fuels, cladding, structural materials and coolant interaction. Other issues include reactor physics, dynamics and diagnostics, core and fuel design. The present report summarizes the work performed during the year 2009. The efforts made include identification of organisations involved in Gen IV issues in the Nordic countries, update of the forum website,, and investigation of capabilities for research within the area of Gen IV. Within the NOMAGE4 project a seminar on Generation IV Nuclear Energy Systems has been organized during 15-16th of October 2009. The aim of the seminar was to provide a forum for exchange of information, discussion on future research needs and networking of experts on Generation IV reactor concepts. As an outcome of the NOMAGE4, a few collaboration project proposals have been prepared/planned in 2009. The network was welcomed by the European Commission and was mentioned as an exemplary network with representatives from industries, universities, power companies and research institutes. NOMAGE4 has been invited to participate to the 'European Energy Research Alliance, EERA, workshop for nuclear structural materials' as external observers. Future plans include a new Nordic application for continuation of NOMAGE4 network. (author)

  2. APACHE IV versus PPI for predicting community hospital ICU mortality. (United States)

    Shrope-Mok, Shaffer R; Propst, Katie A; Iyengar, Rajesh


    Both the Acute Physiology and Chronic Health Evaluation (APACHE) IV and Palliative Performance Index (PPI) are scales used to estimate intensive care unit (ICU) prognosis and mortality. To Compare the diagnostic utility of the PPI and APACHE IV and their subsequent implications in predicting ICU mortality at a community hospital. This was a Prospective Cohort Study. The study was conducted at the Community hospital ICU. Participants were 211 patients admitted from December 24, 2008 to June 11, 2009. An observer gathered appropriate data and performed the APACHE IV and PPI scales within 24 hours of admission. Results were then analyzed using standard formulae. The study included 211 participants in total with 211 participants in the PPI group (n = 211) and 162 in the APACHE IV group (n = 162). The APACHE score and PPI were found to be significant for predicting ICU mortality (P value of P APACHE IV demonstrated a sensitivity of 84.6%, specificity of 96.0%, PPV of 64.7%, and NPV of 98.6%. In contrast, the PPI possessed a sensitivity of 69.2%, specificity of 96.0%, PPV of 64.7%, and NPV of 97.8%. Limitations may have occurred with the subjective nature of the PPI and Glasgow Coma Scale (GCS), along with meeting criterion for the APACHE IV. This prospective cohort study in the ICU of a community hospital demonstrated that both the APACHE IV and PPI were significant tools for predicting ICU mortality. When contrasting the 2 scales, the APACHE IV could more accurately rule in mortality when mortality occurred and rule out mortality when survival occurred.

  3. COBRA-IV: the model and the method

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, C.W.; Wheeler, C.L.; Cena, R.J.; McMonagle, C.A.; Cuta, J.M.; Trent, D.S.


    The objective of this report is to present the mathematical basis of the COBRA-IV computer program (Wheeler et al., 1976) being developed by Battelle, Pacific Northwest Laboratory. The COBRA-IV code is an extended version of the COBRA-IIIC subchannel analysis code that computes the flow and enthalpy distributions in nuclear fuel rod bundles and cores for both steady state and transient conditions (Rowe, 1973).

  4. Ensiapupäivä Hevoshaan koulun viidesluokkalaisille


    Cajas, Paula; Kajander, Sini-Maaria


    Laurea-ammattikorkeakoulu Tiivistelmä Hyvinkää Hoitotyön koulutusohjelma Terveydenhoitotyön koulutusohjelma Paula Cajas & Sini-Maaria Kajander Ensiapupäivä Hevoshaan koulun viidesluokkalaisille Vuosi 2015 Sivumäärä 81 Opinnäytetyömme tarkoituksena oli toteuttaa toiminnallinen ensiapupäivä Hevoshaankoulun viidesluokkalaisille. Tarkoituksenamme oli myös tehdä PowerPoint–esitys teoriasta sekä tuottaa oppilaille jaettavaksi ensiapulehtine...

  5. Oxidation Resistance of Monolayer Group-IV Monochalcogenides. (United States)

    Guo, Yu; Zhou, Si; Bai, Yizhen; Zhao, Jijun


    Ridged, orthorhombic two-dimensional (2D) group-V elemental and group IV-VI compound analogues of phosphorene provide a versatile platform for nanoelectronics, optoelectronics, and clean energy. However, phosphorene is vulnerable to oxygen in ambient air, which is a major obstacle for its applications. Regarding this issue, here we explore the oxidation behavior of monolayer group-IV monochalcogenides (GeS, GeSe, SnS, and SnSe), in comparison to that of phosphorene and arsenene by first-principles calculations. We find superior oxidation resistance of the monolayer group-IV monochalcogenides, with activation energies for the chemisorption of O2 on the 2D sheets in the range of 1.26-1.60 eV, about twice of the values of phosphorene and arsenene. The distinct oxidation behaviors of monolayer group-IV monochalcogenides and group-V phosphorene analogues originate from their different bond natures. Moreover, the chemisorption of a moderate amount of oxygen atoms does not severely deteriorate the electronic band structures of the monolayer group-IV monochalcogenides. These results shine light on the utilization of the monolayer group-IV monochalcogenides for next-generation 2D electronics and optoelectronics with high performance and stability.

  6. Dipeptidyl peptidase IV in two human glioma cell lines

    Directory of Open Access Journals (Sweden)

    A Sedo


    Full Text Available There is growing evidence that dipeptidyl peptidase IV [DPP-IV, EC] takes part in the metabolism of biologically active peptides participating in the regulation of growth and transformation of glial cells. However, the knowledge on the DPP-IV expression in human glial and glioma cells is still very limited. In this study, using histochemical and biochemical techniques, the DPP-IV activity was demonstrated in two commercially available human glioma cell lines of different transformation degree, as represented by U373 astrocytoma (Grade III and U87 glioblastoma multiforme (Grade IV lines. Higher total activity of the enzyme, as well as its preferential localisation in the plasma membrane, was observed in U87 cells. Compared to U373 population, U87 cells were morphologically more pleiomorphic, they were cycling at lower rate and expressing less Glial Fibrillary Acidic Protein. The data revealed positive correlation between the degree of transformation of cells and activity of DPP-IV. Great difference in expression of this enzyme, together with the phenotypic differences of cells, makes these lines a suitable standard model for further 57 studies of function of this enzyme in human glioma cells.

  7. Psychological variables and Wechsler Adult Intelligence Scale-IV performance. (United States)

    Gass, Carlton S; Gutierrez, Laura


    The MMPI-2 and WAIS-IV are commonly used together in neuropsychological evaluations yet little is known about their interrelationships. This study explored the potential influence of psychological factors on WAIS-IV performance in a sample of 180 predominantly male veteran referrals that underwent a comprehensive neuropsychological examination in a VA Medical Center. Exclusionary criteria included failed performance validity testing and self-report distortion on the MMPI-2. A Principal Components Analysis was performed on the 15 MMPI-2 content scales, yielding three broader higher-order psychological dimensions: Internalized Emotional Dysfunction (IED), Externalized Emotional Dysfunction (EED), and Fear. Level of IED was not related to performance on the WAIS-IV Full Scale IQ or its four indexes: (Verbal Comprehension, Perceptual Reasoning, Working Memory, and Processing Speed). EED was not related to WAIS-IV performance. Level of Fear, which encompasses health preoccupations (HEA) and distorted perceptions (BIZ), was significantly related to WAIS-IV Full Scale IQ and Verbal Comprehension. These results challenge the common use of high scores on the MMPI-2 IED measures (chiefly depression and anxiety) to explain deficient WAIS-IV performance. In addition, they provide impetus for further investigation of the relation between verbal intelligence and Fear.

  8. Platinum (IV) coiled coil nanotubes selectively kill human glioblastoma cells. (United States)

    Thanasupawat, Thatchawan; Bergen, Hugo; Hombach-Klonisch, Sabine; Krcek, Jerry; Ghavami, Saeid; Del Bigio, Marc R; Krawitz, Sherry; Stelmack, Gerald; Halayko, Andrew; McDougall, Matthew; Meier, Markus; Stetefeld, Jörg; Klonisch, Thomas


    Malignant glioma are often fatal and pose a significant therapeutic challenge. Here we have employed α-helical right handed coiled coils (RHCC) which self-assemble into tetrameric nanotubes that stably associate with platinum (Pt) (IV) compound. This Pt(IV)-RHCC complex showed superior in vitro and in vivo toxicity in human malignant glioma cells at up to 5 fold lower platinum concentrations when compared to free Pt(IV). Pt(IV)-RHCC nanotubes activated multiple cell death pathways in GB cells without affecting astrocytes in vitro or causing damage to normal mouse brain. This Pt(IV)-RHCC nanotubes may serve as a promising new therapeutic tool for low dose Pt(IV) prodrug application for highly efficient and selective treatment of human brain tumors. The prognosis of malignant glioma remains poor despite medical advances. Platinum, one of the chemotherapeutic agents used, has significant systemic side effects. In this article, the authors employed α-helical right handed coiled coil (RHCC) protein nanotubes as a carrier for cisplatin. It was shown that the new compound achieved higher tumor kill rate but lower toxicity to normal cells and thus may hold promise to be a highly efficient treatment for the future. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. 77 FR 16508 - National Emission Standards for Hazardous Air Pollutant Emissions: Group IV Polymers and Resins... (United States)


    ...: Group IV Polymers and Resins; Pesticide Active Ingredient Production; and Polyether Polyols Production... pollutants: National Emission Standards for Hazardous Air Pollutant Emissions: Group IV Polymers and Resins...: Group IV Polymers and Resins; Pesticide Active Ingredient Production; and Polyether Polyols Production...

  10. Adaptation of the Wechsler Intelligence Scale for Children-IV (WISC-IV) for Vietnam (United States)

    Dang, Hoang-Minh; Weiss, Bahr; Pollack, Amie; Nguyen, Minh Cao


    Intelligence testing is used for many purposes including identification of children for proper educational placement (e.g., children with learning disabilities, or intellectually gifted students), and to guide education by identifying cognitive strengths and weaknesses so that teachers can adapt their instructional style to students’ specific learning styles. Most of the research involving intelligence tests has been conducted in highly developed Western countries, yet the need for intelligence testing is as or even more important in developing countries. The present study, conducted through the Vietnam National University Clinical Psychology CRISP Center, focused on the cultural adaptation of the WISC-IV intelligence test for Vietnam. We report on (a) the adaptation process including the translation, cultural analysis and modifications involved in adaptation, (b) present results of two pilot studies, and (c) describe collection of the standardization sample and results of analyses with the standardization sample, with the goal of sharing our experience with other researchers who may be involved in or interested in adapting or developing IQ tests for non-Western, non-English speaking cultures. PMID:23833330

  11. Adaptation of the Wechsler Intelligence Scale for Children-IV (WISC-IV) for Vietnam. (United States)

    Dang, Hoang-Minh; Weiss, Bahr; Pollack, Amie; Nguyen, Minh Cao


    Intelligence testing is used for many purposes including identification of children for proper educational placement (e.g., children with learning disabilities, or intellectually gifted students), and to guide education by identifying cognitive strengths and weaknesses so that teachers can adapt their instructional style to students' specific learning styles. Most of the research involving intelligence tests has been conducted in highly developed Western countries, yet the need for intelligence testing is as or even more important in developing countries. The present study, conducted through the Vietnam National University Clinical Psychology CRISP Center, focused on the cultural adaptation of the WISC-IV intelligence test for Vietnam. We report on (a) the adaptation process including the translation, cultural analysis and modifications involved in adaptation, (b) present results of two pilot studies, and (c) describe collection of the standardization sample and results of analyses with the standardization sample, with the goal of sharing our experience with other researchers who may be involved in or interested in adapting or developing IQ tests for non-Western, non-English speaking cultures.

  12. The Spanish version of the Wisconsin Personality Disorders Inventory-IV (WISPI-IV): tests of validity and reliability. (United States)

    Smith, Tracey L; Klein, Marjorie H; Alonso, Carmen; Salazar-Fraile, José; Felipe-Castaño, Elena; Moreno, Clara Lopez; Acosta, Silvia Raquel; Rios, Lisbeth Iglesias; Martí-Sanjuán, Vicent


    Personality disorders (PD) are a prevalent class of mental disorders that interfere with functioning and cause subjective distress while increasing the intensity and duration of Axis I clinical syndromes, and therefore assessing PD is important even when PDs are not the focus of treatment. The purpose of these studies was to develop and test a new Spanish version of a self-report measure of PD, the Wisconsin Personality Inventory-IV (WISPI-IV) that would be psychometrically equivalent to the English version while also maintaining the same interpersonal content, which is based on Benjamin's analysis of the PD criteria using her Structural Analysis of Social Behavior (SASB) model (1974). Study 1 participants completed the WISPI-IV twice over a two-week interval. For Study 2, participants from two sites in Spain and one site in Argentina completed Spanish versions of the WISPI-IV and other personality measures. SASB-analysis of the translated items showed high correspondence between the interpersonal content of the English version and the Spanish version demonstrating theoretical validation in relation to other PD measures. The Spanish WISPI-IV showed satisfactory reliability based on test-retest correlations and alphas for internal consistency. Study 2 showed the Spanish WISPI-IV had good convergent validity with the Spanish versions of the IIP and SCID-II and performed similarly to the English versions of these measures. Our goal in translating the WISPI-IV was to extend this measure to Spanish-speakers in language that would be understood by different Hispanic sub-groups, however research team members and subjects had a variety of suggestions for changes in item wording. This reflects the difficulty with creating a "neutral" Spanish version of any assessment given regional differences.


    Directory of Open Access Journals (Sweden)

    Abu Lais Mustaque


    Full Text Available INTRODUCTION Laryngoscopy and intubation is an integral part for providing general anaesthesia to patients undergoing various types of surgery. It also plays an important role in critical care units viz. for providing mechanical ventilation. It is a very essential tool in the hands of anaesthesiologist in maintaining airway. The present study is undertaken to determine and compare the efficacy of single bolus dose of IV esmolol 1 mg/kg and IV fentanyl 2 mcg/kg in attenuating the haemodynamic responses to laryngoscopy and tracheal intubation and to ascertain the effectiveness of esmolol hydrochloride and fentanyl citrate in suppressing sympathetic responses. MATERIAL & METHODS The study was conducted under the Department of Anaesthesiology and Critical Care, Assam Medical College and Hospital, Dibrugarh, during the period July 2013 to June 2014. For this purpose, 150 patients of either sex between 20-50 years of ASA I & II physical status were selected after obtaining informed and written consent and were divided into two groups namely, Group E receiving IV esmolol (1 mg/kg and Group F receiving IV fentanyl (2 mcg/kg. RESULTS Inj. fentanyl 2 mcg/kg IV administered 5 minutes before laryngoscopy and intubation was able to prevent adverse haemodynamic changes better than Inj. esmolol 1 mg/kg IV administered 3 minutes prior to laryngoscopy and intubation during elective surgeries under general anaesthesia. CONCLUSION Hence, from the findings of this study we can conclude that IV bolus dose of fentanyl 2 mcg/kg administered 5 minutes before laryngoscopy and intubation can attenuate the sympathetic response to laryngoscopy and intubation without any side effects of the drug in healthy patients undergoing elective surgeries under general anaesthesia.

  14. Chelation and stabilization of berkelium in oxidation state +IV (United States)

    Deblonde, Gauthier J.-P.; Sturzbecher-Hoehne, Manuel; Rupert, Peter B.; An, Dahlia D.; Illy, Marie-Claire; Ralston, Corie Y.; Brabec, Jiri; de Jong, Wibe A.; Strong, Roland K.; Abergel, Rebecca J.


    Berkelium (Bk) has been predicted to be the only transplutonium element able to exhibit both +III and +IV oxidation states in solution, but evidence of a stable oxidized Bk chelate has so far remained elusive. Here we describe the stabilization of the heaviest 4+ ion of the periodic table, under mild aqueous conditions, using a siderophore derivative. The resulting Bk(IV) complex exhibits luminescence via sensitization through an intramolecular antenna effect. This neutral Bk(IV) coordination compound is not sequestered by the protein siderocalin—a mammalian metal transporter—in contrast to the negatively charged species obtained with neighbouring trivalent actinides americium, curium and californium (Cf). The corresponding Cf(III)-ligand-protein ternary adduct was characterized by X-ray diffraction analysis. Combined with theoretical predictions, these data add significant insight to the field of transplutonium chemistry, and may lead to innovative Bk separation and purification processes.

  15. Coordination Chemistry of Homoleptic Actinide(IV)-Thiocyanate Complexes. (United States)

    Carter, Tyler J; Wilson, Richard E


    The synthesis, X-ray crystal structure, vibrational and optical spectroscopy for the eight-coordinate thiocyanate compounds, [Et4 N]4 [Pu(IV) (NCS)8 ], [Et4 N]4 [Th(IV) (NCS)8 ], and [Et4 N]4 [Ce(III) (NCS)7 (H2 O)] are reported. Thiocyanate was found to rapidly reduce plutonium to Pu(III) in acidic solutions (pHcoordination in acetonitrile based on the observation of intense ligand-to-metal charge-transfer bands. Spectroscopic and crystallographic data do not support the interaction of the metal orbitals with the ligand π system, but support an enhanced An(IV) -NCS interaction, as the Lewis acidity of the metal ion increases from Th to Pu. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. J-Integral characterization of the nozzle steels from intermediate test vessels IV-5 and IV-9

    Energy Technology Data Exchange (ETDEWEB)

    Auten, T.A.; Macdonald, B.D.; Scavone, D.W.; Bozik, D.


    Reported here are the results of elastic-plastic fracture toughness tests performed on low alloy steels from the nozzles of the intermediate test vessels IV-5 and IV-9 from the Heavy Steel Section Technology Program at Oak Ridge National Laboratory. These vessels had been given prototypic nozzle corner flaw tests prior to the development of the ASTM E-813 standard test procedure for J-integral testing. The objective of this work is to provide J-integral material test support for future elastic-plastic fracture mechanics analysis of the nozzles. J-integral tests at 88{degrees}C (190{degrees}F) of the IV-5 nozzle material produced stable ductile tearing. The tearing resistance data are expected to support analysis of the observed similar stable tearing response of the nozzle corner flaw. J-integral tests at 24{degrees}C (75{degrees}F) of the IV-9 nozzle produced elastic-plastic fracture instability preceded by stable tearing. A similar response was observed in the IV-9 nozzle corner flaw test. It will be a major and important challenge to develop a fracture mechanics rationale that reconciles these small specimen and nozzle corner flaw test results. These test results are being made available to allow their use by a wide variety of organizations in developing such a rationale, which would be a significant contribution to quantifying the flaw tolerance of reactor pressure vessels.

  17. Why IV Setup for Stream Ciphers is Difficult

    DEFF Research Database (Denmark)

    Zenner, Erik


    In recent years, the initialization vector (IV) setup has proven to be the most vulnerable point when designing secure stream ciphers. In this paper, we take a look at possible reasons why this is the case, identifying numerous open research problems in cryptography.......In recent years, the initialization vector (IV) setup has proven to be the most vulnerable point when designing secure stream ciphers. In this paper, we take a look at possible reasons why this is the case, identifying numerous open research problems in cryptography....

  18. BCS class IV drugs: Highly notorious candidates for formulation development. (United States)

    Ghadi, Rohan; Dand, Neha


    BCS class IV drugs (e.g., amphotericin B, furosemide, acetazolamide, ritonavir, paclitaxel) exhibit many characteristics that are problematic for effective oral and per oral delivery. Some of the problems associated include low aqueous solubility, poor permeability, erratic and poor absorption, inter and intra subject variability and significant positive food effect which leads to low and variable bioavailability. Also, most of the class IV drugs are substrate for P-glycoprotein (low permeability) and substrate for CYP3A4 (extensive pre systemic metabolism) which further potentiates the problem of poor therapeutic potential of these drugs. A decade back, extreme examples of class IV compounds were an exception rather than the rule, yet today many drug candidates under development pipeline fall into this category. Formulation and development of an efficacious delivery system for BCS class IV drugs are herculean tasks for any formulator. The inherent hurdles posed by these drugs hamper their translation to actual market. The importance of the formulation composition and design to successful drug development is especially illustrated by the BCS class IV case. To be clinically effective these drugs require the development of a proper delivery system for both oral and per oral delivery. Ideal oral dosage forms should produce both a reasonably high bioavailability and low inter and intra subject variability in absorption. Also, ideal systems for BCS class IV should produce a therapeutic concentration of the drug at reasonable dose volumes for intravenous administration. This article highlights the various techniques and upcoming strategies which can be employed for the development of highly notorious BCS class IV drugs. Some of the techniques employed are lipid based delivery systems, polymer based nanocarriers, crystal engineering (nanocrystals and co-crystals), liquisolid technology, self-emulsifying solid dispersions and miscellaneous techniques addressing the P

  19. Research Level I-V and QE Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Emery, Keith


    A summary of key points related to research-level measurements of current-voltage (I-V) and quantum efficiency (QE) for various types of photovoltaic cells include the following: (1) Compare measurements with another trusted laboratory often enough to see the random error; (2) Have a calibration lab calibrate your research cell; (3) Document potential metastabilities and sensitivity to premeasurement conditions; (4) Measure the 1-sun spectral responsivity with a bias light level of 0.37 times the expected 1-sun short-current current; and (5) Be aware of bias rate artifacts in I-V and QE.

  20. Improvement of Steam Generator Reliability for GEN-IV SFR

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seong O; Kim Se Yun; Kim, Seok Hoon; Eoh, Jae Hyuk; Lee, Hyeong Yeon; Choi, Byung Seon


    The R and D items performed in this study were selected from the R and D task of ' Reliability improvement of Steam Generator' of GEN-IV SFR Component Design and BOP. Since this project deals with one of the most important issues for a GEN-IV SFR system, it needs to enhance the domestic technical backgrounds associated with the corresponding R and D items even for a very short period by 2005. This study provides the R and D results for i) Development of assessment methodology for dissimilar metal weld and ii) Development of multi-dimensional simulation methodology for a SWR event in a SFR steam generator.

  1. Court Culture during the Reign of Christian IV

    DEFF Research Database (Denmark)

    Olden-Jørgensen, Sebastian


    Court culture can be defined as a range of cultural forms (festival culture, painting, literature, music, architecture) employed for the enhancement of princely status and the communication of political messages. Christian IV evidently set great store on court culture beginning with his magnificent...... coronation in 1596, reaching a climax with the "great wedding" (of crown prince Christian) in 1634 and at last colapsing during the military and political crisis in the last years of his long reign (1588/96-1648). Danish court culture during the reign of Christian IV decidedly was on an European level...

  2. Plutonium Oxidation and Subsequent Reduction by Mn (IV) Minerals

    Energy Technology Data Exchange (ETDEWEB)



    Plutonium sorbed to rock tuff was preferentially associated with manganese oxides. On tuff and synthetic pyrolusite (Mn{sup IV}O{sub 2}), Pu(IV) or Pu(V) was initially oxidized, but over time Pu(IV) became the predominant oxidation state of sorbed Pu. Reduction of Pu(V/VI), even on non-oxidizing surfaces, is proposed to result from a lower Gibbs free energy of the hydrolyzed Pu(IV) surface species versus that of the Pu(V) or Pu(VI) surface species. This work suggests that despite initial oxidation of sorbed Pu by oxidizing surfaces to more soluble forms, the less mobile form of Pu, Pu(IV), will dominate Pu solid phase speciation during long term geologic storage. The safe design of a radioactive waste or spent nuclear fuel geologic repository requires a risk assessment of radionuclides that may potentially be released into the surrounding environment. Geochemical knowledge of the radionuclide and the surrounding environment is required for predicting subsurface fate and transport. Although difficult even in simple systems, this task grows increasingly complicated for constituents, like Pu, that exhibit complex environmental chemistries. The environmental behavior of Pu can be influenced by complexation, precipitation, adsorption, colloid formation, and oxidation/reduction (redox) reactions (1-3). To predict the environmental mobility of Pu, the most important of these factors is Pu oxidation state. This is because Pu(IV) is generally 2 to 3 orders of magnitude less mobile than Pu(V) in most environments (4). Further complicating matters, Pu commonly exists simultaneously in several oxidation states (5, 6). Choppin (7) reported Pu may exist as Pu(IV), Pu(V), or Pu(VI) oxic natural groundwaters. It is generally accepted that plutonium associated with suspended particulate matter is predominantly Pu(IV) (8-10), whereas Pu in the aqueous phase is predominantly Pu(V) (2, 11-13). The influence of the character of Mn-containing minerals expected to be found in subsurface

  3. 17 CFR Table IV to Subpart E of... - Civil Monetary Penalty Inflation Adjustments (United States)


    ... Inflation Adjustments IV Table IV to Subpart E of Part 201 Commodity and Securities Exchanges SECURITIES AND... Table IV to Subpart E of Part 201—Civil Monetary Penalty Inflation Adjustments Table IV to Subpart E U.S. Code citation Civil monetary penalty inflation adjustments Civil monetary penalty description Year...

  4. From ‘War Culture’ to ‘Culture of Victory’: The Victors and the Construction of Franco’s Dictatorship (1936-1951 | De la cultura de guerra a la cultura de la victoria: los vencedores y la construcción de la dictadura franquista (1936-1951

    Directory of Open Access Journals (Sweden)

    Claudio Hernández Burgos


    Full Text Available This article explores the role of war experience in the construction of Franco’s dictatorship by analyzing the attitudes and behavior of the victors and the regime’s grassroots during the Spanish Civil War and the postwar period. It aims in particular at examining the way in which the war –both on the frontline and at the rearguard– affected many individuals who eventually became the strongest supporters of a culture based on military victory. With a view to that, and departing from a local perspective, it explores the different ways (rewards system, engagement in the regime institutions, collaboration in enemy repression, and establishment of an everlasting victors’ memory in which both dictatorship and social exclusion of the vanquished were firmly laid down. | El presente artículo examina el papel de la experiencia de guerra en la conformación de la dictadura franquista a través del análisis de las actitudes y comportamientos de los vencedores y apoyos sociales del régimen durante la propia Guerra Civil y la posguerra. En concreto, se trata de examinar el modo en que la contienda –ya fuera en el frente o en la retaguardia– influyó a un amplio conjunto de individuos que acabaron por convertirse en los mayores defensores de una cultura cimentada sobre la victoria armada. Para ello, partiendo desde una perspectiva centrada en el plano local, se exploran las diferentes vías (sistema de recompensas, participación en las instituciones del régimen, colaboración en la persecución del enemigo o perpetuación de la memoria de los vencedores a través de las cuales contribuyeron a la consolidación de la dictadura, al tiempo que propiciaron la exclusión social de los perdedores de la guerra.

  5. Electrochemistry and Spectroelectrochemistry of the Pu (III/IV) and (IV/VI) Couples in Nitric Acid Systems

    Energy Technology Data Exchange (ETDEWEB)

    Lines, Amanda M.; Adami, Susan R.; Casella, Amanda J.; Sinkov, Sergey I.; Lumetta, Gregg J.; Bryan, Samuel A.


    The solution chemistry of Pu in nitric acid is explored via electrochemistry and spectroelectrochemistry. By utilizing and comparing these techniques, an improved understanding of Pu behavior and its dependence on nitric acid concentration can be achieved. Here the Pu (III/IV) couple is characterized using cyclic voltammetry, square wave voltammetry, and a spectroelectrochemical Nernst step. Results indicate the formal reduction potential of the couple shifts negative with increasing acid concentration and reversible electrochemistry is no longer attainable above 6 M HNO3. Spectroelectrochemistry is also used to explore the irreversible oxidation of Pu(IV) to Pu(VI) and shine light on the mechanism and acid dependence of the redox reaction.

  6. Parameter extraction from I-V characteristics of PV devices

    Energy Technology Data Exchange (ETDEWEB)

    Macabebe, Erees Queen B. [Department of Electronics, Computer and Communications Engineering, Ateneo de Manila University, Loyola Heights, Quezon City 1108 (Philippines); Department of Physics and Centre for Energy Research, Nelson Mandela Metropolitan University, PO Box 77000, Port Elizabeth 6031 (South Africa); Sheppard, Charles J. [Department of Physics, University of Johannesburg, PO Box 524, Auckland Park 2006 (South Africa); Dyk, E. Ernest van [Department of Physics and Centre for Energy Research, Nelson Mandela Metropolitan University, PO Box 77000, Port Elizabeth 6031 (South Africa)


    Device parameters such as series and shunt resistances, saturation current and diode ideality factor influence the behaviour of the current-voltage (I-V) characteristics of solar cells and photovoltaic modules. It is necessary to determine these parameters since performance parameters are derived from the I-V curve and information provided by the device parameters are useful in analyzing performance losses. This contribution presents device parameters of CuIn(Se,S){sub 2}- and Cu(In,Ga)(Se,S){sub 2}-based solar cells, as well as, CuInSe{sub 2}, mono- and multicrystalline silicon modules determined using a parameter extraction routine that employs Particle Swarm Optimization. The device parameters of the CuIn(Se,S){sub 2}- and Cu(In,Ga)(Se,S){sub 2}-based solar cells show that the contribution of recombination mechanisms exhibited by high saturation current when coupled with the effects of parasitic resistances result in lower maximum power and conversion efficiency. Device parameters of photovoltaic modules extracted from I-V characteristics obtained at higher temperature show increased saturation current. The extracted values also reflect the adverse effect of temperature on parasitic resistances. The parameters extracted from I-V curves offer an understanding of the different mechanisms involved in the operation of the devices. The parameter extraction routine utilized in this study is a useful tool in determining the device parameters which reveal the mechanisms affecting device performance. (author)

  7. Complexation of Plutonium (IV) with Fluoride at Variable Tempeartures

    Energy Technology Data Exchange (ETDEWEB)

    Xia, Yuanxian; Rao, Linfeng; Friese, Judah I.; Moore, Dean A.; Bachelor, P. P.


    Complexation of Pu(IV) with fluoride was studied by solvent extraction at 25, 40 and 55 C in 2.2 mol {center_dot} kg{sup -1} HClO{sub 4}. The distribution ratio of Pu(IV) between the organic and aqueous phases decreased as the concentration of fluoride was increased due to the formation of Pu(IV)-F complexes in the aqueous phase. Two complexes, PuF{sup 3+} and PuF{sub 2}{sup 2+}, were identified under the conditions in this work and their stability constants at 25, 40 and 55 C and I = 2.2 mol {center_dot} kg{sup -1} HClO{sub 4} were determined from the distribution data. The Specific Ion Interaction approach (SIT) was used to extrapolate the constants to the state of infinite dilution. Data from this work indicate that the complexation of Pu(IV) with fluoride is endothermic and entropy-driven. The complexation becomes stronger at higher temperatures.


    African Journals Online (AJOL)


  9. A comparative study of proton transport properties of metal (IV ...

    Indian Academy of Sciences (India)


    A comparative study of proton transport properties of metal (IV) phosphates. HEEMANSHU PATEL and UMA CHUDASAMA*. Department of Applied Chemistry, Faculty of Technology and Engineering,. The M.S. University of Baroda, Vadodara 390 001 e-mail: MS received 14 April 2006; revised 9 ...

  10. Class IV preparation design for microfilled and macrofilled composite resin. (United States)

    Donly, K J; Browning, R


    The current standard preparation for Class IV composite restorations is the placement of a bevel on all enamel margins. This study evaluated chamfered and beveled preparations for Class IV restorations of lesions with microfilled and macrofilled composite resin. Forty incisors were obtained and standardized lesions for Class IV restorations were formed. Twenty teeth had a 1.5-mm bevel placed and 20 had a 1.5-mm chamfered preparation placed. Half of the beveled and chamfered preparations were restored with microfilled composite resin; the remaining were restored with macrofilled composite resin. All restorations were fractured with an Instron Testing Machine. The mean force (lbs +/- SD) to fracture the restorations were: (beveled, microfilled composite 16.0 +/- 4.4); (chamfered, microfilled composite 30.6 +/- 20.0); (beveled, macrofilled composite 34.9 +/- 18.6); (chamfered, macrofilled composite 48.8 +/- 14.3). The chamfered preparations provided greater restoration fracture resistance than beveled preparations, for both microfilled and macrofilled composite restorations. Scheffe's test indicated traditional beveled, microfilled Class IV composite resin restorations significantly decreased fracture resistance compared to chamfered, macrofilled composite restorations (P less than 0.001).

  11. Effect of Cerium(IV)-Surfactant Reaction in Foam Decontamination

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Han Beom; Jung, Chong-Hun; Yoon, In-Ho; Kim, Chorong; Choi, Wang-Kyu [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)


    Using foams allows the decommissioning of complex shaped facilities. The decontamination foam comprises at least one surfactant to generate the foam and one or more chemical reactants to achieve the dissolution of the contaminants at the solid surface. In order to improve the efficiency of decontamination foam, the present study attempts to find the optimum condition of chemical reagents to the foaming solution. The corrosion rate of radioactive nuclides contaminated stainless steel metal is very important factor for the foam decontamination process. The goal of this study is to develop the decontamination process for contaminated stainless steel in medium of nitric acid. Stainless steel needs a strong oxidizing agent such as Ce(IV) ion and the effects of cerium(IV). Surfactant interaction involved in foam decontamination and finally the improvement brought by formulation science. The formulation of foams loaded with strong oxidizing reagents such as Ce(IV) is an important factor. The enhanced decontamination properties of nitric acid with Ce(IV) additive on stainless steel is well known in liquid mediums. stainless steel metal is an important aspect in the foam decontamination process.

  12. Nascent transcription affected by RNA polymerase IV in Zea mays. (United States)

    Erhard, Karl F; Talbot, Joy-El R B; Deans, Natalie C; McClish, Allison E; Hollick, Jay B


    All eukaryotes use three DNA-dependent RNA polymerases (RNAPs) to create cellular RNAs from DNA templates. Plants have additional RNAPs related to Pol II, but their evolutionary role(s) remain largely unknown. Zea mays (maize) RNA polymerase D1 (RPD1), the largest subunit of RNA polymerase IV (Pol IV), is required for normal plant development, paramutation, transcriptional repression of certain transposable elements (TEs), and transcriptional regulation of specific alleles. Here, we define the nascent transcriptomes of rpd1 mutant and wild-type (WT) seedlings using global run-on sequencing (GRO-seq) to identify the broader targets of RPD1-based regulation. Comparisons of WT and rpd1 mutant GRO-seq profiles indicate that Pol IV globally affects transcription at both transcriptional start sites and immediately downstream of polyadenylation addition sites. We found no evidence of divergent transcription from gene promoters as seen in mammalian GRO-seq profiles. Statistical comparisons identify genes and TEs whose transcription is affected by RPD1. Most examples of significant increases in genic antisense transcription appear to be initiated by 3'-proximal long terminal repeat retrotransposons. These results indicate that maize Pol IV specifies Pol II-based transcriptional regulation for specific regions of the maize genome including genes having developmental significance. Copyright © 2015 by the Genetics Society of America.

  13. Workshop IV – Cosmology-theoretical models/alternative scenarios ...

    Indian Academy of Sciences (India)

    Workshop IV – Cosmology-theoretical models/alternative scenarios: A report. ASIT BANERJEE. ½ and REZA TAVAKOL. 2. ½. Department of Physics, Jadavpur University, Calcutta 700 032, India. ¾. Astronomy Unit, School of Mathematical Sciences, Queen Mary and Westfield College, Mile End. Road, London E1 4NS, UK.

  14. Trade and Industrial Policy Strategies (TIPS) Core Grant - Phase IV ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Trade and Industrial Policy Strategies (TIPS) Core Grant - Phase IV. Established in 1996, Trade and Industrial Policy Strategies (TIPS) is an organization that coordinates a network of researchers that seeks to provide the Government of South Africa, civil society and the region with independent advice on economic policy, ...

  15. Study of the cerium(IV)-picrate system in acetonitrile. (United States)

    Kratochvil, B; Tipler, M; McKay, B


    A potentiometric and spectrophotometric study has been made of the reaction between hexanitratocerate and picrate in dry acetonitrile. Several cerium(IV)-picrate complexes are formed; the formation constant for the first is estimated to be 4 from spectrophotometric measurements. The catalytic effect of picrate on hydroquinone oxidation by nitratocerate is postulated to be due to more rapid electron transfer by cerium picrate complexes.


    African Journals Online (AJOL)

    BETTY FREUND: A NURSE IN FRANCE PART IV. Compiled and edited by Betty Hugo. BETTY'S LETTERS HOME. 3 July 1916 ... I told you I was nursing an old Commandant ... he died last Sunday morning, his wife was not here and he kept saying I had not to leave him one moment. I was not a bit afraid he is the first.

  17. CASE REPORT Dual (type IV) left anterior descending artery

    African Journals Online (AJOL)

    [1] Type IV can be differentiated from the other types by the long LAD originating from the RCA. Case report. A 52-year-old man was referred to our hospital for chest pain during exercise. The physical examination and laboratory findings were unremarkable. The patient underwent coronary CT angiography (CTA).

  18. Neoadjuvant chemotherapy in patients with stages III/IV breast ...

    African Journals Online (AJOL)

    Neoadjuvant chemotherapy in patients with stages III/IV breast cancer disease surgical experience at Muhimbili National Hospital, Dar es Salaam, Tanzania. ... Radiotherapy was given to any patient in either group where suspicion of residual tumor was present. Patients' data were entered in an SPSS window 11.5 program ...

  19. Mirizzi syndrome grades III and IV: surgical treatment

    Directory of Open Access Journals (Sweden)


    Full Text Available ABSTRACT Objective : to evaluate the epidemiology and outcomes of surgical treatment of patients with Mirizzi Syndrome (MS grades III and IV, the most advanced according to Csendes classification. Methods : we conducted a retrospective, cross-sectional study by reviewing records of thirteen patients with grades III and IV MS operated from December 2001 to September 2013, among the 3,691 cholecystectomies performed in the period. Results : the incidence of MS was 0.6% (23 cases and grades III and IV amounted to 0.35% of this number. There was a predominance of type IV (12 cases. The preoperative diagnosis was possible in 53.8% of cases. The preferred approach was biliary-digestive derivation (10 cases, and "T" tube drainage with suture of the bile duct was the choice in three special occasions. Three patients had biliary fistula resolved with clinical management, and one coliperitoneum case required reoperation. In the outpatient follow-up of patients who underwent biliodigestive anastomosis (eight, 50% are asymptomatic, 25% had anastomotic stricture and 25% lost follow-up. The mean follow-up was 41.8 months. Conclusion : MS in advanced degrees has low incidence, preoperative diagnosis in only half of cases, and has the biliodigestive anastomosis as the best conduct, but not without morbidity.

  20. Solar Neutrino Measurements in Super-Kamiokande-IV

    CERN Document Server

    :,; Haga, Y; Hayato, Y; Ikeda, M; Iyogi, K; Kameda, J; Kishimoto, Y; Marti, Ll; Miura, M; Moriyama, S; Nakahata, M; Nakajima, T; Nakayama, S; Orii, A; Sekiya, H; Shiozawa, M; Sonoda, Y; Takeda, A; Tanaka, H; Takenaga, Y; Tasaka, S; Tomura, T; Ueno, K; Yokozawa, T; Akutsu, R; Irvine, T; Kaji, H; Kajita, T; Kametani, I; Kaneyuki, K; Lee, K P; Nishimura, Y; McLachlan, T; Okumura, K; Richard, E; Labarga, L; Fernandez, P; Blaszczyk, F d M; Gustafson, J; Kachulis, C; Kearns, E; Raaf, 32 J L; Stone, J L; Sulak, 32 L R; Berkman, S; Tobayama, S; Goldhaber, M; Bays, K; Carminati, G; Griskevich, N J; Kropp, W R; Mine, S; Renshaw, A; Smy, M B; Sobel, H W; Takhistov, V; Weatherly, P; Ganezer, K S; Hartfiel, B L; Hill, J; Keig, W E; Hong, N; Kim, J Y; Lim, I T; Park, R G; Akiri, T; Albert, J B; Himmel, A; Li, Z; O'Sullivan, E; Scholberg, K; Walter, C W; Wongjirad, T; Ishizuka, T; Nakamura, T; Jang, J S; Choi, K; Learned, J G; Matsuno, S; Smith, S N; Friend, M; Hasegawa, T; Ishida, T; Ishii, T; Kobayashi, T; Nakadaira, T; Nakamura, K; Nishikawa, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Tsukamoto, T; Nakano, Y; Suzuki, A T; Takeuchi, Y; Yano, T; Cao, S V; Hayashino, T; Hiraki, T; Hirota, S; Huang, K; Ieki, K; Jiang, M; Kikawa, T; Minamino, A; Murakami, A; Nakaya, T; Patel, N D; Suzuki, K; Takahashi, S; Wendell, R A; Fukuda, Y; Itow, Y; Mitsuka, G; Muto, F; Suzuki, T; Mijakowski, P; Frankiewicz, K; Hignight, J; Imber, J; Jung, C K; Li, X; Palomino, J L; Santucci, G; Taylor, I; Vilela, C; Wilking, M J; Yanagisawa, C; Fukuda, D; Ishino, H; Kayano, T; Kibayashi, A; Koshio, Y; Mori, T; Sakuda, M; Takeuchi, J; Yamaguchi, R; Kuno, Y; Tacik, R; Kim, S B; Okazawa, H; Choi, Y; Ito, K; Nishijima, K; Koshiba, M; Totsuka, Y; Suda, Y; Yokoyama, M; Nantais, C M; Martin, J F; de Perio, P; Tanaka, H A; Konaka, A; Chen, S; Sui, H; Wan, L; Yang, Z; Zhang, H; Zhang, Y; Connolly, K; Dziomba, M; Wilkes, R J


    Upgraded electronics, improved water system dynamics, better calibration and analysis techniques allowed Super-Kamiokande-IV to clearly observe very low-energy 8B solar neutrino interactions, with recoil electron kinetic energies as low as 3.49 MeV. Super-Kamiokande-IV data-taking began in September of 2008; this paper includes data until February 2014, a total livetime of 1664 days. The measured solar neutrino flux is (2.308+-0.020(stat.) + 0.039-0.040(syst.)) x 106/(cm2sec) assuming no oscillations. The observed recoil electron energy spectrum is consistent with no distortions due to neutrino oscillations. An extended maximum likelihood fit to the amplitude of the expected solar zenith angle variation of the neutrino-electron elastic scattering rate in SK-IV results in a day/night asymmetry of (-3.6+-1.6(stat.)+-0.6(syst.))%. The SK-IV solar neutrino data determine the solar mixing angle as sin2 theta_12 = 0.327+0.026-0.031, all SK solar data (SK-I, SK-II, SK III and SKIV) measures this angle to be sin2 the...

  1. IV srpsko-bugarska konferencija u Zrenjaninu 2005. godine

    Directory of Open Access Journals (Sweden)

    Dragana Antonijević


    Full Text Available U Zrenjaninu je  od 25. do 28. oktobra 2005. godine održana IV srpsko-bugarska konferencija na temu "Svakodnevna kultura u postsocijalističkom periodu u Srbiji i Bugarskoj: balkanska transformacija i evropska integracija". Konferenciju su organizovali Etnografski institut SANU iz Beograda, Etnografski institut i muzej BAN iz Sofije i Narodni muzej Zrenjanin.

  2. Studies on the genus Atriplex L. (Amaranthaceae) in Italy. IV ...

    African Journals Online (AJOL)

    Studies on the genus Atriplex L. (Amaranthaceae) in Italy. IV. Atriplex bocconei Guss. – Atriplex bocconei Guss. is here typified on one herbarium specimen kept in NAP. The identity of the species is also clarified on the basis of literature analysis and examination of type material and other specimens that allowed to include it ...

  3. Streptococcus agalactiae Serotype IV in Humans and Cattle, Northern Europe

    DEFF Research Database (Denmark)

    Lyhs, Ulrike; Kulkas, Laura; Katholm, Jorgen


    not differentiate between populations isolated from different host species. Isolates from humans and cattle differed in lactose fermentation, which is encoded on the accessory genome and represents an adaptation to the bovine mammary gland. Serotype IV-ST196 isolates were obtained from multiple dairy herds in both...

  4. Osteogenesis imperfecta Type IV: a newly identified variant at ...

    African Journals Online (AJOL)

    Osteogenesis imperfecta is a clinically heterogenous disease caused by defective collagen syntesis associated with a mutation in the COL1A1 or COL1A2 genes. In this report, we present a case of osteogenesis imperfecta (OI) type IV, seen in a female fetus with incurved femurs at 18 weeks of gestation. Molecular analysis ...

  5. Liquid Propellant Blast Yields for Delta IV Heavy Vehicles (United States)


    interface of the first stage fuel and oxidizer tanks. Upon contacting the sand surface, shock waves propagate through the liquid propellants and...Research Triangle Institute, Cocoa Beach, FL, 30 July 2004. LIQUID PROPELLANT BLAST YIELDS FOR DELTA IV HEAVY VEHICLES Ron R. Lambert ACTA Lompoc, CA

  6. FACES IV and the Circumplex Model: Validation Study (United States)

    Olson, David


    Family Adaptability and Cohesion Evaluation Scale (FACES) IV was developed to tap the full continuum of the cohesion and flexibility dimensions from the Circumplex Model of Marital and Family Systems. Six scales were developed, with two balanced scales and four unbalanced scales designed to tap low and high cohesion (disengaged and enmeshed) and…

  7. Tetrakis(bis(trimethylsilyl)amido)uranium(IV): synthesis and reactivity. (United States)

    Lewis, Andrew J; Williams, Ursula J; Carroll, Patrick J; Schelter, Eric J


    The synthesis of the sterically saturated uranium(IV) complex U[N(SiMe3)2]4 (1) is demonstrated from the one-electron oxidation of U[N(SiMe3)2]3 with a variety of oxidants in THF. A high yielding synthesis of 1 directly from UI3(THF)4 is provided.

  8. The PCP SYS IV Management System: Implementation and Training Overview. (United States)

    Silver, Dorothy Z.; Clapp, Elizabeth J.

    This is the final paper in a series of three on SYS IV, a computer-based management system developed by the PLATO Curriculum Project (PCP) which tests students, routes students to lessons, stores detailed records of online student activity, and keeps summary records of student activities. An introduction describes how the system simultaneously…

  9. 25 CFR 36.13 - Standard IV-Curriculum development. (United States)


    ... 25 Indians 1 2010-04-01 2010-04-01 false Standard IV-Curriculum development. 36.13 Section 36.13... § 36.13 Standard IV—Curriculum development. (a) Each school shall implement an organized program of curriculum development involving certified and non-certified staff and shall provide the opportunity for...

  10. Clinical Utility of Cancellation on the WISC-IV (United States)

    Zhu, Jianjun; Chen, Hsinyi


    This study examined empirical evidence for clinical utility of the Wechsler Intelligence Scale for Children, fourth edition (WISC-IV) cancellation subtest by comparing data from 597 clinical and 597 matched control children. The results of dependent t and sequential logistic regression analyses demonstrated that (a) children with intellectual…

  11. Adult, isolated respiratory chain complex IV deficiency with minimal manifestations. (United States)

    Finsterer, Josef; Kovacs, Gabor G; Rauschka, Helmut; Ahting, Uwe


    Isolated complex IV (cytochrome c oxidase) deficiency is one of the most frequent respiratory chain defects in mitochondrial disorders (MIDs) and usually occurs together with severe pediatric or rarely adult multisystem disease. Here we report an adult with isolated complex IV deficiency with unusually mild clinical manifestations. A 50-year-old man had developed generalized muscle aches and occasional twitching and stiffness of the musculature since age 48 years. He had a previous history of diabetes, acute hearing loss, hyperlipidemia, hyperuricemia, arterial hypertension, polyarthrosis, hypogonadism, and hypothyroidism. The family history was positive for diabetes (mother), CK elevation (brother), myalgias (brother), and proximal weakness of the upper limbs (mother). Work-up revealed hypoacusis, postural tremor and reduced tendon reflexes, recurrent mild hyper-CK-emia, neurogenic needle electromyography, and a muscle biopsy with mild non-specific changes. Biochemical investigations of the muscle homogenate revealed an isolated complex IV defect and reduced amounts of coenzyme Q (CoQ). He profited from CoQ supplementation, low-carbohydrate diet, and gluten-free diet. Isolated complex IV deficiency may present with only mild muscular, endocrine, or cardiac manifestations in adults. Coenzyme Q supplementation, low-carbohydrate diet, and gluten-free diet may have a beneficial effect at least on some of the manifestations.

  12. Sargent-IV Project. Development of new methodologies for safety analysis of Generation IV reactors; Proyecto SARGEB-IV. Desarrollo de nuevas metodologias de analisis de seguridad para reactores de Generacion IV

    Energy Technology Data Exchange (ETDEWEB)

    Queral, C.; Gallego, E.; Jimenez, G.


    The main result of this paper is the proposal for the addition of new ingredients in the safety analysis methodologies for Generation-IV reactors that integrates the features of probabilistic safety analysis within deterministic. This ensures a higher degree of integration between the classical deterministic and probabilistic methodologies.

  13. Counsellors Respond to the DSM-IV-TR (United States)

    Strong, Tom; Gaete, Joaquin; Sametband, Ines N.; French, Jared; Eeson, Jen


    The Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) is an administrative fact for many counsellors. This psychiatric approach to formulating client concerns runs counter to those used by counsellors of many approaches (e.g., systemic, feminist). Using an online survey of counsellors (N = 116), invited contributions to a website…

  14. Coefficient of work-hardening in stage-IV

    CSIR Research Space (South Africa)

    Nabarro, FRN


    Full Text Available The theory of work hardening in stage IV depends on the relation between the relative misorientation Psi of neighbouring subgrains and the plastic strain gamma (Psi = B gamma exp). The value of the constant B is suggested to be better related...

  15. Hafnium(IV) complexation with oxalate at variable temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Friend, Mitchell T.; Wall, Nathalie A. [Washington State Univ., Pullmanm, WA (United States). Dept. of Chemistry


    Appropriate management of fission products in the reprocessing of spent nuclear fuel (SNF) is crucial in developing advanced reprocessing schemes. The addition of aqueous phase complexing agents can prevent the co-extraction of these fission products. A solvent extraction technique was used to study the complexation of Hf(IV) - an analog to fission product Zr(IV) - with oxalate at 15, 25, and 35 C in 1 M HClO{sub 4} utilizing a {sup 175+181}Hf radiotracer. The mechanism of the solvent extraction system of 10{sup -5} M Hf(IV) in 1 M HClO{sub 4} to thenoyltrifluoroacetone (TTA) in toluene demonstrated a 4{sup th}-power dependence in both TTA and H{sup +}, with Hf(TTA){sub 4} the only extractable species. The equilibrium constant for the extraction of Hf(TTA){sub 4} was determined to be log K{sub ex}=7.67±0.07 (25±1 C, 1 M HClO{sub 4}). The addition of oxalate to the aqueous phase decreased the distribution ratio, indicating aqueous Hf(IV)-oxalate complex formation. Polynomial fits to the distribution data identified the formation of Hf(ox){sup 2+} and Hf(ox){sub 2(aq)} and their stability constants were measured at 15, 25, and 35 C in 1 M HClO{sub 4}. van't Hoff analysis was used to calculate Δ{sub r}G, Δ{sub r}H, and Δ{sub r}S for these species. Stability constants were observed to increase at higher temperature, an indication that Hf(IV)-oxalate complexation is endothermic and driven by entropy.

  16. Cytomorphologic features distinguishing Bethesda category IV thyroid lesions from parathyroid

    Directory of Open Access Journals (Sweden)

    Simon Sung


    Full Text Available Background: Thyroid follicular cells share similar cytomorphological features with parathyroid. Without a clinical suspicion, the distinction between a thyroid neoplasm and an intrathyroidal parathyroid can be challenging. The aim of this study was to assess the distinguishing cytomorphological features of parathyroid (including intrathyroidal and Bethesda category IV (Beth-IV thyroid follicular lesions, which carry a 15%–30% risk of malignancy and are often followed up with surgical resection. Methods: A search was performed to identify “parathyroid” diagnoses in parathyroid/thyroid-designated fine-needle aspirations (FNAs and Beth-IV thyroid FNAs (follicular and Hurthle cell, all with diagnostic confirmation through surgical pathology, immunocytochemical stains, Afirma® analysis, and/or clinical correlation. Unique cytomorphologic features were scored (0-3 or noted as present versus absent. Statistical analysis was performed using R 3.3.1 software. Results: We identified five FNA cases with clinical suspicion of parathyroid neoplasm, hyperthyroidism, or thyroid lesion that had an eventual final diagnosis of the parathyroid lesion (all female; age 20–69 years and 12 Beth-IV diagnoses (11 female, 1 male; age 13–64 years. The following cytomorphologic features are useful distinguishing features (P value: overall pattern (0.001, single cells (0.001, cell size compared to red blood cell (0.01, nuclear irregularity (0.001, presence of nucleoli (0.001, nuclear-to-cytoplasmic ratio (0.007, and nuclear chromatin quality (0.028. Conclusions: There are cytomorphologic features that distinguish Beth-IV thyroid lesions and (intrathyroidal parathyroid. These features can aid in rendering correct diagnoses and appropriate management.

  17. Endogeneity in Panel Data Models with Time-Varying and Time-Fixed Regressors: To IV or not IV?

    DEFF Research Database (Denmark)

    Mitze, Timo

    We analyse the problem of parameter inconsistency in panel data econometrics due to the correlation of exogenous variables with the error term.A common solution in this setting is to use Instrumental-Variable (IV) estimation in the spirit of Hausman-Taylor (1981). However, some potential shortcom...

  18. The Effect of Doping with Ti(IV) and Sn(IV) on Oxygen Reduction at Hematite Electrodes

    Energy Technology Data Exchange (ETDEWEB)

    Balko, Barbara A.(4112); Clarkson, Kathleen M.(Lewis and Clark College)


    We examined the reduction of oxygen at doped hematite (a-Fe2O3) electrodes to determine how the identity of the dopant affected the reaction and how changes in reactivity compared with changes in dopant concentration. Our results indicated that Sn(IV) and Ti(IV) dopants have a similar effect on the open-circuit potential, cathodic transfer coefficient, and exchange current density, suggesting that any bandgap states associated with the introduction of dopants and directly involved in the reduction of oxygen have similar energies. The greatest difference between the electrodes doped with Sn(IV) and Ti(IV) was in the apparent cathodic transfer coefficient. The cathodic transfer coefficients for the Sn-doped electrodes were slightly smaller than those for the Ti-doped, suggesting that the density of interface states is greater in the Sn-doped electrodes. In comparing electrodes with two different dopant concentrations, we found that the relative increase in reactivity was significantly less than the increase in dopant concentration. This may be due to the electrochemical creation of surface Fe(II) sites that catalyze the reduction of O2. Other factors that may also contribute include bandgap states associated with the dopants and the fact that not all the dopants lead to creation of Fe(II) sites.

  19. Functionalization of group IV semiconductors; Funktionalisierung von Gruppe IV-Halbleitern

    Energy Technology Data Exchange (ETDEWEB)

    Hoeb, Marco Andreas


    The present work is focused on the structural and electronic properties of thermally and photochemically grafted alkene molecules. The semiconductor substrates used in this work are the group IV-semiconductors silicon, diamond, and silicon carbide. On silicon, functionalization via the commonly known hydrosilylation reaction was performed. During thermal treatment in vacuum-distilled 1-octadecene, the alkene molecules covalently added to the substrate via Si-C bond formation, resulting in self-assembled organic monolayers. The reaction resulted in smooth and homogeneous alkyl-terminated surfaces. Static water contact angles were determined to be 113 . Photoelectron spectroscopy was performed and showed no evidence of surface oxidation. The high packing of the organic layers is indicated by the asymmetric methylene vibrational mode, which has been redshifted by -4 cm{sup -1} with respect to the liquid alkene mode position. The average molecular tilt-angle of the alkyl-molecules, relative to the surface normal, has been identified to be 34 . The transport properties have been determined to be dominated by tunneling processes. On diamond, first results on the thermal functionalization of hydrogen- and oxygen-terminated surfaces are demonstrated. Thermal functionalization with octadecene showed high selectivity, while hydrogenated diamond surfaces were found to be inert to the thermally induced reaction with alkenes. In contrast, alkene molecules were successfully grafted to oxygen-terminated sites via covalent C-O-C bonds. Reaction temperatures as high as 160 C were necessary to initiate the functionalization process.Wetting experiments on the alkyl-modified surfaces revealed contact angle values of 103 . The high quality of the monolayers on oxygenated surfaces was confirmed by IR-spectroscopy. In addition, polarized IR-measurements indicated a tilt angle of 23 . On silicon carbide, thermal and UV-induced alkoxylation were studied. Hydrofluoric acid treatment

  20. Outcome of surgical treatment of type IV capitellum frac-

    Directory of Open Access Journals (Sweden)

    Singh Ajay Pal


    Full Text Available 【Abstract】 Objective: Fractures of the capitellum and trochlea constitute less than 1% of all elbow fractures and a shear fracture involving the capitellum and extending medially into most of the trochlea is rarely reported. Type IV capitellum fracture is still controversial in regard to its ra-diographic appearance, surgical approach and osteosynthesis. We report 10 cases of type IV capitellum fracture with a view to elucidating its clinical features and treatment outcome. Methods: We treated 10 patients of type IV capitellum fracture with a mean age of 32 years. A uniform surgical approach and postoperative rehabilitation were followed. Results: Nine patients presented to us after a mean of 4 days of injury and one patient was nonunion after 6 months of injury who had been treated conservatively by a bone setter. Double arc sign was absent in 6 cases. Intraopera-tively 6 capitellotrochlear fragments were devoid of soft Chin J Traumatol 2012;15(4:201-205 DOI: 10.3760/cma.j.issn.1008-1275.2012.04.002 Punjab Civil Medical Services-I Mukerian, Punjab, In-dia (Singh AP Department of Orthopaedics, UCMS & GTB Hospital, Delhi, India (Dhammi IK and Garg V Swami Premanand Hospital, Mukerian, Punjab, India (Singh AP *Corresponding author: Tel: 98-72069734, Email: C oronal shear fractures of distal end of humeral articular surface involve the capitellum and trochlea. These fractures are difficult to assess accurately on plain radiographs and the limited amount of subchondral bone available for stable internal fixation makes the operative treatment equally difficult. 1 Joint stiffness, instability and osteoarthrosis are complications resulting from treatment failures. 2 The major classification systems are proposed by Bryan and Dubberley et al. 3,4 Type IV fracture is a fracture involving the capitellum and extends to more than lateral half of the trochlea. 1 We report an analysis of ten cases of type IV capi-tissue attachments. By

  1. STRAP IV - High accuracy, low drift attitude control system. (United States)

    Shrewsberry, D. J.; Budney, T. J.; Riley, D. C.; Schuler, B. C.


    The STRAP IV attitude control system was designed, tested, and successfully launched to provide stable high accuracy pointing at nontrackable X-ray sources. On its initial flight (May 19, 1972), the STRAP IV control system updated its high accuracy, rate integrating gyros on two successive stellar targets and then maneuvered the rocket body to point the experimental payload at two separate X-ray sources and an X-ray-free background location. The third axis, which remained under the control of a coarse free gyro, was updated by a technique of successive star-target coordinate transformation to ensure the correct fine-axis azimuth alignment for the high accuracy inertial maneuvers. Pointing accuracies of 4 arc min with limit cycle stability of less than 20 arc sec peak to peak were obtained on all targets.

  2. Validation of the Portuguese DSM-IV-MR-J. (United States)

    Calado, Filipa; Alexandre, Joana; Griffiths, Mark D


    Youth problem gambling is viewed as an emergent public health issue in many countries, and is also an emerging area of public concern in Portugal. However, there is currently no Portuguese instrument that focuses specifically on the measurement of problem gambling among young people. Consequently, the present study aimed to validate the DSM-IV-MR-J for use among Portuguese adolescents and to examine its' psychometric properties. A cross-cultural adaption of this instrument to the Portuguese language was performed using the translation and back translation method. The final version of the instrument was administered to 753 Portuguese high school and first year college students. The findings revealed an acceptable internal reliability and replicated the one-factor structure of this scale. Based on these findings, the Portuguese DSM-IV-MR-J appears to be a valid and reliable instrument, and provides a much needed psychometric tool for the development of more research on youth gambling in Portugal.

  3. Target Selection for the SDSS-IV APOGEE-2 Survey

    Energy Technology Data Exchange (ETDEWEB)

    Zasowski, G. [Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112 (United States); Cohen, R. E.; Carlberg, J. K.; Fleming, Scott W. [Space Telescope Science Institute, Baltimore, MD 21218 (United States); Chojnowski, S. D.; Holtzman, J. [Department of Astronomy, New Mexico State University, Las Cruces, NM 88001 (United States); Santana, F. [Departamento de Astronomía, Universidad de Chile, Santiago (Chile); Oelkers, R. J.; Bird, J. C. [Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37235 (United States); Andrews, B. [PITT PACC, Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, PA 15260 (United States); Beaton, R. L. [The Observatories of the Carnegie Institution for Science, Pasadena, CA 91101 (United States); Bender, C.; Cunha, K. [Steward Observatory, The University of Arizona, Tucson, AZ 85719 (United States); Bovy, J. [Department of Astronomy and Astrophysics and Dunlap Institute for Astronomy and Astrophysics, University of Toronto, Toronto, ON M5S 3H4 (Canada); Covey, K. [Department of Physics and Astronomy, Western Washington University, Bellingham, WA 98225 (United States); Dell’Agli, F.; García-Hernández, D. A. [Departamento de Astrofísica, Universidad de La Laguna, and Instituto de Astrofísica de Canarias, La Laguna, Tenerife (Spain); Frinchaboy, P. M. [Department of Physics and Astronomy, Texas Christian University, Fort Worth, TX 76129 (United States); Harding, P. [Department of Astronomy, Case Western Reserve University, Cleveland, OH 44106 (United States); Johnson, J. A., E-mail: [Department of Astronomy, The Ohio State University, Columbus, OH 43210 (United States); and others


    APOGEE-2 is a high-resolution, near-infrared spectroscopic survey observing ∼3 × 10{sup 5} stars across the entire sky. It is the successor to APOGEE and is part of the Sloan Digital Sky Survey IV (SDSS-IV). APOGEE-2 is expanding on APOGEE’s goals of addressing critical questions of stellar astrophysics, stellar populations, and Galactic chemodynamical evolution using (1) an enhanced set of target types and (2) a second spectrograph at Las Campanas Observatory in Chile. APOGEE-2 is targeting red giant branch and red clump stars, RR Lyrae, low-mass dwarf stars, young stellar objects, and numerous other Milky Way and Local Group sources across the entire sky from both hemispheres. In this paper, we describe the APOGEE-2 observational design, target selection catalogs and algorithms, and the targeting-related documentation included in the SDSS data releases.


    Directory of Open Access Journals (Sweden)

    Dejаn Gojković


    Full Text Available Problem physical activities children younger school-age children, with the basic tasks research is construction kinesitherapy adequate prevention and avoid postural disorders spinal column, optimal ontogenetic level morphological( anthropological development.The main objective research is contents teaching physical education as well as and content that can be put in regular program teaching physical education with the basic task prevention potential and eliminate disorders spinal column, with auxiliary a harmonious biological development. The entities from which he was carried out sample size for this research is defined as population students male primary schools I- IV grade.The first and basic condition was that they are included in teaching physical education in the course of this research sample is taked 400 respondents.-according to the manner elections respondents sample was targeted selected.were taken I- IV grade elementary schools in Bijeljina, Teslic, Foca and Pale.

  5. Spinal type IV arteriovenous malformations (perimedullary fistulas) in children. (United States)

    Sure, U; Wakat, J P; Gatscher, S; Becker, R; Bien, S; Bertalanffy, H


    Intradural perimedullary spinal arteriovenous fistula (AVF) is a synonym for type IV spinal arteriovenous malformation (AVM). It is an important clinical differential diagnosis in all patients with slowly progressive or acute spinal symptoms. Perimedullary AVFs are rare in the paediatric age group. We report the treatment regimen and the clinico-radiological findings for these malformations at our institution. Of four paediatric patients, three individuals with persistent fistulas after endovascular treatment were operated on. The malformations were obliterated completely in all patients without any morbidity. In three patients previously documented neurological symptoms resolved during follow-up. If slowly progressive or acute radicular or medullary symptoms arise in children, a spinal arteriovenous malformation should be ruled out by MRI. A combined endovascular and surgical treatment of paediatric spinal AVM type IV (perimedullary AVFs) carries a low risk of morbidity and is reasonably effective.

  6. Kinetic determination of Se(IV in pharmaceutical samples

    Directory of Open Access Journals (Sweden)

    D. A. KOSTIC


    Full Text Available A kinetic method is described for the determination of Se(IV based on its inhibiting effect on the Fe(III catalysis of the oxidation of C6H5COONa with hydrogen peroxide. The detection limit is 0.06 µg cm-3. The relative error ranges between 2.1 and 9.5 % for the concentration interval 0.26 to 2.6 µg cm-3. Kinetic equations are proposed for the investigated process. The effects of certain foreign ions upon the reaction rate were determined in order to assess the selectivity of the method. the method was applied for the determination of Se(IV in pharmaceutical samples.

  7. Sequence Domain Harmonic Modeling of Type-IV Wind Turbines

    DEFF Research Database (Denmark)

    Guest, Emerson; Jensen, Kim Høj; Rasmussen, Tonny Wederberg


    A sequence domain (SD) harmonic model of a gridconnected voltage-source converter is developed for decoupling converter generated voltage harmonics from voltage harmonics in the external grid. The modeling procedure includes a derivation of the baseband frequency response for regular......-sampled pulsewidth modulation and an analysis of converter generated voltage harmonics due to compensated dead-time. The decoupling capabilities of the proposed the SD harmonic model are verified through a power quality (PQ) assessment of a 3MW Type-IV wind turbine. The assessment shows that the magnitude and phase...... of low-order odd converter generated voltage harmonics are dependent on the converter operating point and the phase of the fundamental component of converter current respectively. The SD harmonic model can be used to make PQ assessments of Type-IV wind turbines or incorporated into harmonic load flows...

  8. DSM-5 Personality Traits and DSM-IV Personality Disorders (United States)

    Hopwood, Christopher J.; Thomas, Katherine M.; Markon, Kristian E.; Wright, Aidan G.C.; Krueger, Robert F.


    Two issues pertinent to the DSM-5 proposal for personality pathology, the recovery of DSM-IV personality disorders (PDs) by proposed DSM-5 traits and the validity of the proposed DSM-5 hybrid model which incorporates both personality pathology symptoms and maladaptive traits, were evaluated in a large undergraduate sample (N = 808). Proposed DSM-5 traits as assessed with the Personality Inventory for DSM-5 explained a substantial proportion of variance in DSM-IV PDs as assessed with the Personality Diagnostic Questionnaire-4+, and trait indicators of the six proposed DSM-5 PDs were mostly specific to those disorders with some exceptions. Regression analyses support the DSM-5 hybrid model in that pathological traits and an indicator of general personality pathology severity provided incremental information about PDs. Findings are discussed in the context of broader issues around the proposed DSM-5 model of personality disorders. PMID:22250660

  9. Mirizzi syndrome grades III and IV: surgical treatment. (United States)

    Reverdito, Ronald; Moricz, André DE; Campos, Tércio DE; Pacheco, Adhemar Monteiro; Silva, Rodrigo Altenfelder


    : to evaluate the epidemiology and outcomes of surgical treatment of patients with Mirizzi Syndrome (MS) grades III and IV, the most advanced according to Csendes classification. : we conducted a retrospective, cross-sectional study by reviewing records of thirteen patients with grades III and IV MS operated from December 2001 to September 2013, among the 3,691 cholecystectomies performed in the period. : the incidence of MS was 0.6% (23 cases) and grades III and IV amounted to 0.35% of this number. There was a predominance of type IV (12 cases). The preoperative diagnosis was possible in 53.8% of cases. The preferred approach was biliary-digestive derivation (10 cases), and "T" tube drainage with suture of the bile duct was the choice in three special occasions. Three patients had biliary fistula resolved with clinical management, and one coliperitoneum case required reoperation. In the outpatient follow-up of patients who underwent biliodigestive anastomosis (eight), 50% are asymptomatic, 25% had anastomotic stricture and 25% lost follow-up. The mean follow-up was 41.8 months. : MS in advanced degrees has low incidence, preoperative diagnosis in only half of cases, and has the biliodigestive anastomosis as the best conduct, but not without morbidity. avaliar a epidemiologia e os resultados do tratamento cirúrgico de doentes portadores de graus III e IV, mais avançados, da Síndrome de Mirizzi (SM) de acordo com a classificação de Csendes. estudo retrospectivo, de corte transversal através da revisão de prontuários de 13 pacientes portadores de graus III e IV da SM operados de dezembro de 2001 a setembro de 2013, entre 3691 colecistectomias realizadas neste período. a incidência da SM foi 0,6% (23 casos) e os graus III e IV perfizeram 0,35% deste número. Houve um predomínio de tipo IV (12 casos). O diagnóstico pré-operatório foi possível em 53,8% dos casos. A conduta preferencial foi derivação biliodigestiva (10 casos) e foi optado por drenagem

  10. [The possible temporal lobe syndrome of Ivan IV the Terrible]. (United States)

    Espinoza G, Ricardo; Benavides S, Evelyn


    Ivan IV "The Terrible" was the first Tsar of all Russias and was crowned in 1547. He extended Russian territories and opened the route to Siberia in successful campaigns against Tartars. He increased his personal power to the point of generating an autocracy that isolated him progressively from the council of Boyars. He had a complex personality and his acts were impregnated by a profound religiousness, episodes of rage, mood changes and a sense of "personal fate". All these traits configure the controversial "temporal lobe personality". The possible association between these personality traits and the eventual epilepsy that Ivan IV could suffer, is discussed. This association is called "temporal lobe syndrome". Considering the mood changes, with severe irritability and episodes of control loss alternated with feelings of guilt, sadness and isolation, another possibility is that the Tsar had an affective bipolar disorder or, less probably, a personality disorder.

  11. Target Selection for the SDSS-IV APOGEE-2 Survey (United States)

    Zasowski, G.; Cohen, R. E.; Chojnowski, S. D.; Santana, F.; Oelkers, R. J.; Andrews, B.; Beaton, R. L.; Bender, C.; Bird, J. C.; Bovy, J.; Carlberg, J. K.; Covey, K.; Cunha, K.; Dell’Agli, F.; Fleming, Scott W.; Frinchaboy, P. M.; García-Hernández, D. A.; Harding, P.; Holtzman, J.; Johnson, J. A.; Kollmeier, J. A.; Majewski, S. R.; Mészáros, Sz.; Munn, J.; Muñoz, R. R.; Ness, M. K.; Nidever, D. L.; Poleski, R.; Román-Zúñiga, C.; Shetrone, M.; Simon, J. D.; Smith, V. V.; Sobeck, J. S.; Stringfellow, G. S.; Szigetiáros, L.; Tayar, J.; Troup, N.


    APOGEE-2 is a high-resolution, near-infrared spectroscopic survey observing ∼3 × 105 stars across the entire sky. It is the successor to APOGEE and is part of the Sloan Digital Sky Survey IV (SDSS-IV). APOGEE-2 is expanding on APOGEE’s goals of addressing critical questions of stellar astrophysics, stellar populations, and Galactic chemodynamical evolution using (1) an enhanced set of target types and (2) a second spectrograph at Las Campanas Observatory in Chile. APOGEE-2 is targeting red giant branch and red clump stars, RR Lyrae, low-mass dwarf stars, young stellar objects, and numerous other Milky Way and Local Group sources across the entire sky from both hemispheres. In this paper, we describe the APOGEE-2 observational design, target selection catalogs and algorithms, and the targeting-related documentation included in the SDSS data releases.

  12. Campylobacteremia in stage IV gliosarcoma with bevacizumab treatment

    Directory of Open Access Journals (Sweden)

    Ping Liu


    Full Text Available Primary campylobacter enteritis with secondary bacteremia was diagnosed in an immunocompromised patient with stage IV gliosarcoma. She developed mild diarrhea followed by systemic symptoms with transient generalized weakness and fever. She was treated with azithromycin and had a full recovery and without relapse through 2 months of follow-up. Her diagnosis was confirmed by a positive stool culture for Campylobacter sp. and blood culture for Campylobacter jejuni/coli.

  13. Stark widths and shifts for spectral lines of Sn IV (United States)

    de Andrés-García, I.; Alonso-Medina, A.; Colón, C.


    In this paper, we present theoretical Stark widths and shifts calculated corresponding to 66 spectral lines of Sn IV. We use the Griem semi-empirical approach and the COWAN computer code. For the intermediate coupling calculations, the standard method of least-squares fitting from experimental energy levels was used. Data are presented for an electron density of 1017 cm-3 and temperatures T = 1.1-5.0 (104 K). The matrix elements used in these calculations have been determined from 34 configurations of Sn IV: 4d10ns(n = 5-10), 4d10nd(n = 5-8), 4d95s2, 4d95p2, 4d95s5d, 4d85s5p2 and 4d105g for even parity and 4d10np(n = 5-8), 4d10nf (n = 4-6), 4d95snp(n = 5-8), 4d85s25p and 4d95snf (n = 4-10) for odd parity. Also, in order to test the matrix elements used in our calculations, we present calculated values of radiative lifetimes of 14 levels of Sn IV. There is good agreement between our calculations and the experimental radiative lifetimes obtained from the bibliography. The spectral lines of Sn IV are observed in UV spectra of HD 149499 B obtained with the Far Ultraviolet Spectroscopic Explorer, the Goddard High Resolution Spectrograph and the International Ultraviolet Explorer. Theoretical trends of the Stark broadening parameter versus the temperature for relevant lines are presented. Also our values of Stark broadening parameters have been compared with the data available in the bibliography.

  14. Fluorescent antitumor titanium(iv) salen complexes for cell imaging. (United States)

    Tzubery, Avia; Melamed-Book, Naomi; Tshuva, Edit Y


    Two differently substituted fluorescent salen Ti(iv) complexes were developed. One was inactive on human cancer cells, whereas the other showed high cytotoxicity. Based on live cell imaging, both complexes penetrated the cell, but were not detected in the nuclei. Moreover, the inactive complex was trapped in endocytic vesicles, whereas the active complex accumulated in the perinuclear region and inflected phototoxicity upon continuous irradiation.

  15. Proliferation resistances of Generation IV recycling facilities for nuclear fuel


    Åberg Lindell, Matilda


    The effects of global warming raise demands for reduced CO2 emissions, whereas at the same time the world’s need for energy increases. With the aim to resolve some of the difficulties facing today’s nuclear power, striving for safety, sustainability and waste minimization, a new generation of nuclear energy systems is being pursued: Generation IV. New reactor concepts and new nuclear facilities should be at least as resistant to diversion of nuclear material for weapons production, as were th...

  16. Deconstructing the DSM-IV-TR: a critical perspective. (United States)

    Warelow, Philip; Holmes, Colin A


    This paper examines and offers a critique of the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR), underlying principles and assumptions, and the nature and consequences of its nosological framework. The reason for this critique is to look at the rationale for some of the diagnostic categories and also why some categories are retained, including some of the long-standing diagnostic groups, such as schizophrenia. It is not the intention here to rehearse the problems of biological psychiatric thinking, nor argue the strengths and weaknesses of the DSM-IV-TR in its definitions and descriptions of particular syndromes and illnesses. The ideas presented here derive from a range of previous research that argued that the DSM-IV-TR colludes in a system of psychiatric care in which all people, by virtue of characteristically human foibles and idiosyncrasies, are potentially classifiable into a variety of diagnostic mental health categories. In the present study, it was argued that because of resource constraints, professional dispute, and public concern, the major criterion for attracting a formal diagnosis is not classifiability according to the DSM-IV-TR, but rather, that of 'social risk', defined in terms of risk to oneself and/or others and embodying obvious social control functions. Here, we expand and develop some of these ideas, and relate them more specifically to insights offered by critical or deconstructive psychology and the development of the forthcoming the DSM-V. © 2011 The Authors. International Journal of Mental Health Nursing © 2011 Australian College of Mental Health Nurses Inc.

  17. Dipeptidyl peptidase IV inhibitory activity of protein hydrolyzates ...

    African Journals Online (AJOL)

    Dipeptidyl peptidase IV inhibitory activity of protein hydrolyzates from Amaranthus hypochondriacus L. Grain and their influence on postprandial glycemia in Streptozotocin-induced diabetic mice. S-S Jorge, R-B Raúl, G-L Isabel, P-A Edith, E-BH Bernardo, A-PJ César, D-G Gerardo, R-R Rubén ...

  18. Botswana; Staff Report for the 2002 Article IV Consultation


    International Monetary Fund


    This 2002 Article IV Consultation highlights that real GDP growth of Botswana slipped to an estimated 1¼ percent in 2001/02 (July–June), largely reflecting a downturn in the global diamond market and a drop in Botswana’s diamond production. The non-mining sectors performed better, especially the service industries. Their success is in part a product of Botswana’s market-friendly environment, sound macroeconomic policies, and investments in education and physical infrastructure. The overall fi...

  19. An Introductory Description of the ILLIAC IV System. Volume 1 (United States)


    m r AN INTRODUCTORY DESCRIPTION OF THE ILLIAC IV SYSTEM Volume I by- Stewart A. Denenberg I Accession For NTIS 6RA&I DTIC TAB Unannounced... MANIAC (Los Alamos) and WEIZIAC (Woizman Institute of Israel) soon followed and were patterned after the IAS machine. They all had addition times of...ultrasonic storage is the long access time. The time required for an accumulator to access a bit in storage varies from near zero, to the time it takes a

  20. Association of systemic collagen type IV formation with survival among patients undergoing hemodialysis

    DEFF Research Database (Denmark)

    Leeming, Diana Julie; Karsdal, Morten A; Rasmussen, Lars M


    The 7S domain of collagen type IV (P4NP_7S) assessed in plasma represents systemic collagen type IV formation. The objective of the study was to investigate the association of systemic collagen type IV formation with survival among patients undergoing hemodialysis.......The 7S domain of collagen type IV (P4NP_7S) assessed in plasma represents systemic collagen type IV formation. The objective of the study was to investigate the association of systemic collagen type IV formation with survival among patients undergoing hemodialysis....

  1. Recent advances on the difructose anhydride IV preparation from levan conversion. (United States)

    Hang, Hua


    Difructose anhydride IV (DFA IV) is a cyclic disaccharide consisting of two fructose residues, which is obtained from levan conversion with levan fructotransferase (LFTase) and rarely found in nature as a low-calorie sugar substitute. Some beneficial effects of DFA IV connected with its consumption have been described. The article reviews the properties and physiological functions of DFA IV, levan conversion, resources and properties of LFTase and the produced methods of DFA IV. LFTase as a relatively novel enzyme and its molecular evolution are discussed as well. The aim is to better understand a novel sugar-substituting sweetener of DFA IV as a food additive.

  2. Group IV direct band gap photonics: Methods, Challenges and Opportunities

    Directory of Open Access Journals (Sweden)

    Richard eGeiger


    Full Text Available The concept of direct band gap group IV materials offers a paradigm change for Si-photonics concerning the monolithic implementation of light emitters: The idea is to integrate fully compatible group IV materials with equally favorable optical properties as the chemically incompatible group III-V-based systems. The concept involves either mechanically applied strain on Ge or alloying of Ge with Sn and permits to drastically improve the insufficient radiative efficiency of Ge. The favorable optical properties result from a modified band structure transformed from an indirect to a direct one. The first demonstration of such a direct band gap laser, accomplished in GeSn, exemplifies the capability of this new concept. These systems may permit a qualitative as well as a quantitative expansion of Si-photonics into traditional but also new areas of applications, provided they can be operated energy efficiently, under ambient conditions and integrated with current Si technologies. This review aims to discuss the challenges along this path in terms of fabrication, characterization and fundamental understanding, and will elaborate on evoking opportunities of this new class of group IV-based laser materials.

  3. Dibutylammonium bis(hydrogen methylphosphonato-κOtriphenylstannate(IV

    Directory of Open Access Journals (Sweden)

    Tidiane Diop


    Full Text Available The asymmetric unit of the title organotin salt, (C8H20N[Sn(C6H53(CH4O3P2], contains two dibutylammonium cations and two stannate(IV anions consisting each of two monodentately bonding methyl hydrogenphosphate groups attached to an Sn(C6H5 unit. The overall coordination environment of the two SnIV atoms is trigonal–bipyramidal defined by three phenyl C atoms in equatorial positions and two methyl hydrogenphosphate O atoms at the apical sites. In the crystal, the stannate(IV anions are linked to each other via pairs of short O—H...O hydrogen bonds, leading to an infinite chain extending parallel to the b-axis direction. Neighbouring chains are linked by N—H...O hydrogen bonds involving the butylammonium cations, giving a two-dimensional structure parallel to the ab plane. The crystal under investigation was found to be twinned by reticular merohedry with twin fractions of 0.5342 (7:0.4658 (7.

  4. Transformation of Tri-Titanium(IV)-Substituted α-Keggin Polyoxometalate (POM) into Tetra-Titanium(IV)-Substituted POMs : Reaction Products of Titanium(IV) Sulfate with the Dimeric Keggin POM Precursor under Acidic Conditions


    Kenji Nomiya; Shoko Yoshida; Yoshitaka Kobayashi; Yoshitaka Sakai; Yuki Mouri


    Reaction products of titanium(IV) sulfate in HCl-acidic aqueous solution with the dimeric species linked through three intermolecular Ti-O-Ti bonds of the two tri-titanium(IV)-substituted α-Keggin polyoxometalate (POM) subunits are described. Two novel titanium(IV)-containing α-Keggin POMs were obtained under different conditions. One product was a dimeric species through two intermolecular Ti-O-Ti bonds of the two tetra-titanium(IV)-substituted α-Keggin POM subunits, i.e., [[{Ti(H2O)3}2(μ-O)...

  5. Selections from 2017: Mapping the Universe with SDSS-IV (United States)

    Kohler, Susanna


    Editors note:In these last two weeks of 2017, well be looking at a few selections that we havent yet discussed on AAS Nova from among the most-downloaded paperspublished in AAS journals this year. The usual posting schedule will resume in January.Sloan Digital Sky Survey IV: Mapping the Milky Way, Nearby Galaxies, and the Distant UniversePublished June2017Main takeaway:The incredibly prolific Sloan Digital Sky Survey has provided photometric observations of around 500 million objects and spectra for more than 3 million objects. The survey has now entered its fourth iteration, SDSS-IV, with the first public data release made in June 2016. A publication led by Michael Blanton (New York University) describes the facilities used for SDSS-IV, its science goals, and itsthree coreprograms.Why its interesting:Since data collection began in 2000, SDSS has been one of the premier surveysproviding imaging and spectroscopy for objects in both the near and distant universe.SDSS has measured spectra not only for the stars in our own Milky Way, but also for galaxies that lie more than 7 billion light-years distant making itan extremelyuseful and powerful tool for mapping our universe.What SDSS-IV is looking for:SDSS image of an example MaNGA target galaxy (left), with some of the many things we can learn about it shown in the right and bottom panels: stellar velocity dispersion, stellar mean velocity, stellar population age, metallicity, etc. [Blanton et al. 2017]SDSS-IV containsthree core programs:Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2)provides high-resolution near-infrared spectra of hundreds of thousands of Milky-Way stars with the goal ofimproving our understanding of the history of the Milky Way and of stellar astrophysics.Mapping Nearby Galaxies at Apache Point Observatory (MaNGA)obtains spatially resolved spectra for thousands of nearby galaxiesto better understand the evolutionary histories of galaxies and what regulates their star formation

  6. Amine and Titanium (IV Chloride, Boron (III Chloride or Zirconium (IV Chloride-Promoted Baylis-Hillman Reactions

    Directory of Open Access Journals (Sweden)

    Shi-Cong Cui


    Full Text Available The Baylis-Hillman reactions of various aryl aldehydes with methyl vinyl ketone at temperatures below -20oC using Lewis acids such as titanium (IV chloride, boron (III chloride or zirconium (IV chloride in the presence of a catalytic amount of selected amines used as a Lewis bases afford the chlorinated compounds 1 as the major product in very high yields. Acrylonitrile can also undergo the same reaction to give the corresponding chlorinated product in moderate yield. A plausible reaction mechanism is proposed. However, if the reaction was carried out at room temperature (ca. 20oC, then the Z-configuration of the elimination product 3, derived from 1, was formed as the major product.

  7. The Universal Arrow of Time III-IV:(Part III) Nonquantum gravitation theory (Part IV) Quantum gravitation theory


    Kupervasser, Oleg


    The paper consists of the two independent papers - the first one about Nonquantum Gravitation theory, the second one about Quantum Gravitation theory (Part III: Nonquantum Gravitation theory) The first paper is dealing with the analysis of general relativity theory (theory of gravitation) from the point of view of thermodynamic time arrow. Within this framework "informational paradox" for black holes and "paradox with the grandfather" for time travel "wormholes" are resolved. (Part IV: Quantu...

  8. Vom work Book Journal, 2011 2nd Edition Victor

    African Journals Online (AJOL)


    with vector control programmes, have been the main stay of trypanosomosis control in Africa in the absence of effective vaccine against the disease. Drug control ..... Febiger. Philadelphia. SOULSBY, E.J.L. (1986): Helminths, Arthropods and th. Protozoa of domesticated animals. 8 edition. Balliere tindall, London. 514 – 533.

  9. Vom work Book Journal, 2011 2nd Edition Victor

    African Journals Online (AJOL)


    SUMMARY. Thirty six BALB/C mice were divided into three groups of twelve each (10 infected and 2 control) and cyclically infected with three genetically distinct types of Trypanosoma congolense (Savannah; SV, Riverine/Forest; RF, and. Kenya Coast; KC). Parasitaemia, haematology and gross and microscopic lesions ...

  10. Vom work Book Journal, 2011 2nd Edition Victor

    African Journals Online (AJOL)


    accelerators or nuclear reactors and fall out. X-rays. People have always been exposed to very low levels of ionizing radiation, their existence was th not appreciated until November 8 1895 when. Wilhelm Conrad Roentgen, a German Physicists, investigating the properties of electrical charges through cathode ray tubes, ...

  11. Vom work Book Journal, 2011 2nd Edition Victor

    African Journals Online (AJOL)


    occurring in parts of West Africa shared the same cause (i.e. virus now called Peste de petits ruminants). Investigators ..... sensitive, and differentiates between PPR and rinderpest. Standardized reagent kits for ICE are ... hooves and less hairy parts of the body and lameness (Radostits et al., 2000). Coccidiosis: This is a ...

  12. Vom work Book Journal, 2011 2nd Edition Victor

    African Journals Online (AJOL)


    6. Table I: Prevalence level of some dental abnormalities in Nigerian Camels. Table II. Prevalence and severity of dental abnormalities in Camels from Sokoto, North West Nigeria. Skull ID. SPLIT. TOOTH. ATTRI-. TION. GR. STAINS. EROSION.

  13. Vom work Book Journal, 2011 2nd Edition Victor

    African Journals Online (AJOL)


    their handling, storage and use due to internal. (ingestion, or inhalation or absorption through broken or intact skin) or external exposure. Radiation doses absorbed are often difficult to evaluate and depend on physical and chemical factor forms of the materials, mode of entry and the individual's metabolism. An irradiated ...

  14. Vom work Book Journal, 2011 2nd Edition Victor

    African Journals Online (AJOL)


    cycle stages and transovarial passage within the tick vector (Uilenberg, 2006). Other theileria species that have been recorded in dogs using. 18S rRNA gene includes Theileria equi and. Theileria annulata (Criado-Fornelio et al.,. 2003b). In essence, the previous notion of. Babesia spp being solely responsible for canine.

  15. Vom work Book Journal, 2011 2nd Edition Victor

    African Journals Online (AJOL)


    of Trypanosomes in Trypanosoma congolense Infected Balb/C Mice. GARBA, M. Comparative Pathology Laboratory ... Human chagasic infection with T.cruzi was evaluated also using the immunoperoxidase method in order to .... endogenous tissue peroxidase activity. Horseradish peroxidase and rabbit anti- horseradish ...

  16. Vom work Book Journal, 2011 2nd Edition Victor

    African Journals Online (AJOL)


    SUMMARY. A retrospective cohort study on slaughter–mediated pregnancy wastage in abattoirs and slaughter points record from January 1998 to December 2009 in the Sahel region of Nigeria revealed an incidence of 22.78 % in sheep and. 17.88 % in goats. During the study period, a total of. 440,917 sheep and 826,435 ...

  17. Victor or Villain? Wernher von Braun and the Space Race (United States)

    O'Brien, Jason L.; Sears, Christine E.


    Set during the Cold War and space race, this historical role-play focuses on Wernher von Braun's involvement in and culpability for the use of slave laborers to produce V-2 rockets for Nazi Germany. Students will grapple with two central questions. Should von Braun have been allowed to emigrate to the United States given his affiliation with the…

  18. Emem ......... 53 geria: A Victor S. .......... 69 ocratic - Osuya

    African Journals Online (AJOL)

    Strength is the high capacity and potency of body and mind required to sustain commitment. Hence ... relationship between the character and the action is betrayed by his later claim, in Poetics XV, that “Tragedy is .... bodies floating " and warns that all that can be done to avoid this fire is “Caution” (15). He receives Gallwey ...

  19. Epacadostat and Vaccine Therapy in Treating Patients With Stage III-IV Melanoma (United States)


    Mucosal Melanoma; Recurrent Melanoma; Recurrent Uveal Melanoma; Stage IIIA Skin Melanoma; Stage IIIA Uveal Melanoma; Stage IIIB Skin Melanoma; Stage IIIB Uveal Melanoma; Stage IIIC Skin Melanoma; Stage IIIC Uveal Melanoma; Stage IV Skin Melanoma; Stage IV Uveal Melanoma

  20. Towards Revised Step IV MICE Optics in the Absence of M1 SSD

    Energy Technology Data Exchange (ETDEWEB)

    Bayes, R. [Univ. of Glasgow, Scotland (United Kingdom); Berg, J. S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Blackmore, V. [Imperial College, London (United Kingdom); Hunt, C. [Imperial College, London (United Kingdom); Liu, A. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Pasternak, J. [Imperial College, London (United Kingdom); Rogers, C. T. [Science and Technology Facilities Council (STFC), Oxford (United Kingdom). Rutherford Appleton Lab. (RAL)


    During magnet commissioning in September 2015, the leads on coil M1 of the downstream spectrometer solenoid failed. The coil will not be operational for MICE Step IV. Revised optics settings for the Step IV data taking are reviewed.

  1. Complexes of Ge(IV)- and Sn(IV)-fluorides with cyclic and acyclic carbenes: bis(dialkylamino)-difluoromethylenes as carbene sources. (United States)

    Böttcher, Tobias; Bassil, Bassem S; Röschenthaler, Gerd-Volker


    Carbene complexes of Ge(IV)- and Sn(IV)-fluorides have been synthesized by oxidative addition of 2,2-difluoro-1,3-dimethylimidazolidine and bis(dimethylamino)difluoromethane to GeCl(2)•dioxane and SnF(2). Chloride analogs of the Ge(IV) complexes were also isolated. All compounds were characterized in the solid state by single-crystal X-ray diffraction.

  2. Domain and basement membrane specificity of a monoclonal antibody against chicken type IV collagen



    A monoclonal antibody, IV-IA8, generated against chicken type IV collagen has been characterized and shown to bind specifically to a conformational-dependent site within a major, triple helical domain of the type IV molecule. Immunohistochemical localization of the antigenic determinant with IV-IA8 revealed that the basement membranes of a variety of chick tissues were stained but that the basement membrane of the corneal epithelium showed little, if any, staining. Thus, basement membranes ma...

  3. Long-term risk of complications after mid-urethral sling IVS implantation

    Directory of Open Access Journals (Sweden)

    Grzegorz Surkont


    In the case of post-IVS complication, as much tape as possible should be excised. Long-term follow up on patients with IVS implantation should be recommended to the centres where IVS tape was used, even to patients after removal of the tape. Risk of erosion, extrusion and infection after midurethral multifilament microporous IVS tape implantation is too high – which is the reason it should no longer be used.

  4. Indicators of suboptimal performance embedded in the Wechsler Memory Scale : Fourth Edition (WMS-IV)

    NARCIS (Netherlands)

    Bouman, Z.; Hendriks, M.P.H.; Schmand, B.A.; Kessels, R.P.C.; Aldenkamp, A.P.


    INTRODUCTION: Recognition and visual working memory tasks from the Wechsler Memory Scale-Fourth Edition (WMS-IV) have previously been documented as useful indicators for suboptimal performance. The present study examined the clinical utility of the Dutch version of the WMS-IV (WMS-IV-NL) for the

  5. Effects of difructose dianhydride (DFA)-IV on in vitro fertilization in pigs. (United States)

    Yi, Young-Joo; Kamala-Kannan, S; Lim, Jeong-Muk; Oh, Byung-Taek; Lee, Sang-Myeong


    Difructose dianhydride IV (DFA-IV) is produced from levan, which is a natural polysaccharide that belongs to the fructan family, through the activity of levan fructotransferase (LF) derived from microorganisms. Recently, DFA-IV has been expected to have diverse applications in the food and medical industry. Here, we examined the potential application of DFA-IV forin vitro fertilization (IVF) in pigs. In the assessment of acrosomal integrity during incubation, intact acrosomal or viable spermatozoa were highly sustained in 0.1% or 0.25% DFA-IV (69.8%-70.8%,PDFA-IV, and 0.1%-0.5% DFA-IV in particular significantly decreased ROS production relative to that seen with no addition or 0.75% DFA-IV. Total fertilization (mono+ polyspermic oocyte) rate was significantly higher in the addition of 0.1% DFA-IV (94.2%) than with other concentrations (71.8%-86.7%,PDFA-IV significantly increased the fertilization rate (PDFA-IV exhibited higher embryonic development and blastocyst formation than those treated with other concentrations (PDFA-IV during IVF improved fertilization and embryonic development, suggesting the possible use of novel sugars for enhancement of assisted reproductive technology (ART) in mammals.

  6. Synthesis of Oxovanadium(IV Complexes with Tetraaza Coordinating Ligands

    Directory of Open Access Journals (Sweden)

    Sanjay Singh


    Full Text Available Oxovanadium(IV complexes of the type [VO(mac]SO4 (where mac = tetraaza macrocyclic ligands derived by condensation of thenil with 1,4-diaminobenzene or 3,4-diaminopyridine and their reaction with β-diketones have been prepared using vanadyl ion as kinetic template. The prepared macrocyclic complexes were characterized by elemental analyses, molar conductance, magnetic moments, and infrared, electronic, and electron spin resonance data. From the spectroscopic studies, five-coordinate square-pyramidal geometry for the VO2+ complexes have been proposed wherein derived ligands act as tetradentate chelating agents.

  7. Terra e terror em Phase IV, de Saul Bass

    Directory of Open Access Journals (Sweden)

    Juliana Fausto


    Full Text Available Os anos 1970 foram palco de uma onda de filmes do gênero eco-horror, dos quais se destaca Phase IV (1974, único longa-metragem dirigido por Saul Bass. O filme é tomado no artigo como um experimento diante da interpelação de povos não-humanos, no caso, as formigas, à humanidade, representada pelo discurso científico. Tendo em vista a atual catástrofe ambiental, propõe-se que o cinema seja um lugar privilegiado para o desenvolvimento de um aparato mítico-real capaz de lidar com o fim do mundo humano.

  8. Stage IV Primary Vaginal Leiomyosarcoma with Lung and Breast Metastases (United States)

    Gong, Lin; Liu, Hui; Yang, Kai-Xuan; Peng, Zhi-Lan


    Background Reproductive tract sarcomas metastasizing to the breast are uncommon. To our knowledge, metastasis of vaginal leiomyosarcoma to the breast has not been previously reported in the literature. Case Report We present the first report of a FIGO stage IV primary vaginal leiomyosarcoma with metastases to the lung and left breast. Treatment included neoadjuvant chemotherapy followed by surgery and postoperative chemotherapy. Lung metastasis disappeared but recurred 14 months later in conjunction with left breast metastasis which was resected. Conclusion Primary vaginal sarcoma with lung and breast metastases is very rare in female genital malignancies. We present this case to alert gynecologists to the need for early diagnosis and aggressive management. PMID:22740804

  9. Unta palloon -toimintapäivät nuorille


    Vesamäki, Tiia; Pohjalainen, Emmi


    UNTA PALLOON - TOIMINTAPÄIVÄT NUORILLE Pohjalainen, Emmi & Vesamäki, Tiia Satakunnan ammattikorkeakoulu Terveydenhoitotyön koulutusohjelma Maaliskuu 2012 Ohjaaja: Lahtinen, Elina Sivumäärä: 50 Liitteitä: 32 Asiasanat: uni, nuoret, terveyden edistäminen Opinnäytetyön tarkoituksena oli järjestää Unta palloon -toimintapäivä Rauman ylä-koulujen kahdeksasluokkalaisille (n=397), Ankkurin koulun 7 – 9 luokkalaisille oppilaille (n=34) sekä WinNovan oppipajaryhmälle (n...

  10. Tribenzylchlorido(triphenylphosphine oxide-κOtin(IV

    Directory of Open Access Journals (Sweden)

    Kong Mun Lo


    Full Text Available In the title tribenzylchloridotin–triphenylphosphine adduct, [Sn(C7H73Cl(C18H15OP], the SnIV atom is in a trans-C3SnClO trigonal–bipyramidal geometry and is displaced out of the C3Sn girdle in the direction of the axial Cl atom by 0.112 (1 in one independent molecule and by 0.167 (1 Å in the other. The phenyl ring of one of the six benzyl units was refined as equally disordered over two sets of sites.

  11. MAX-IV lattice, dynamic properties and magnet system

    Energy Technology Data Exchange (ETDEWEB)

    Tarawneh, H. E-mail:; Eriksson, M.; Lindgren, L-J.; Anderberg, B


    At MAX-LAB the next synchrotron light source MAX-IV is currently studied (Proceedings of the seventh European Particle Accelerator Conference, EPAC 02, Paris, France, 2002). In this paper, we present a possible lattice with horizontal emittance of 1.2 nm rad at an energy of 3 GeV. The possibilities to realise the main magnetic system with high gradient integrated magnets are studied with 2D and 3D magnetic field programs. The dynamic properties for the lattice are also studied and some higher order corrections are discussed.

  12. Clinical Outcome of a FIGO Stage IV Gestational Choriocarcinoma

    Directory of Open Access Journals (Sweden)

    Vera Milenković


    Full Text Available Choriocarcinoma is the most malignant tumor of gestational trophoblastic disease arising from any gestation. It has a tendency toward relapse as well as metastasis. Here, a case of relapsed high-risk choriocarcinoma (FIGO stage IV, WHO score 12 in a 37-year-old female presenting with vaginal bleedings is described. Relapse developed at the site of the surgical scar from hysterectomy that had been performed 2 years earlier. Although the patient was treated with aggressive chemotherapy, she was in a bad general condition and died from infection and liver insufficiency.

  13. Short range order in elemental liquids of column IV. (United States)

    Mayo, M; Shor, S; Yahel, E; Makov, G


    The short range order (SRO) in liquid elements of column IV is analysed within the quasi-crystalline model across a wide range of temperatures. It is found that l-Si, Ge, and Sn are well described with a beta-tin like SRO. In contrast, Pb retains a bcc-like SRO similar to other simple elemental liquids. However, a distinction is found between the SRO in Si and Ge and that in Sn, where the latter has a more rigid structure. This difference persists across the entire temperature range examined but is overcome in Si at pressures above 8 GPa, where the liquid structure evolves towards that of Sn.

  14. La sucesión de Enrique IV

    Directory of Open Access Journals (Sweden)

    María Isabel del Val Valdivieso


    Full Text Available Quizá resulte superfluo señalar que el problema que se plantea a lo largo del reinado de Enrique IV, en torno a su sucesión, no es sino uno de los episodios más espectaculares de la lucha por el poder que tiene lugar en la Castilla de ese momento. No obstante se hace necesario partir de esa observación a la hora de explicar las causas y el desarrollo de esa lucha, así como el por qué de la aparición del problema sucesorio.

  15. Iron(II)- or vanadium(IV)-containing siliceous gels


    Hutter, Frank; Schmidt, Helmut K.; Scholze, Horst


    Iron(II)-containing SiO2 gels can be prepared by the hydrolysis and condensation of tetramethoxysilane in methanolic solutions of iron(II) chloride. These gels show an absorption at 1000 nm indicating the presence of iron(II). In opposition to that, iron(II) cannot be introduced into organically modified gels of the 3-glycidyloxypropyltrimethoxysilane type. Vanadium(IV) can be incorporated into both gels. Unlike the SiO2 gels, the organically modified gels are compact and elastic. The spectra...

  16. Oulusa opitaan! : Täydennyskoulutuspäivä optikoille


    Heikkinen, Marita; Kaikkonen, Katri; Kujala, Johanna; Välkky, Titta


    Nykypäivän työelämän muutokset tuovat omat haasteensa myös optiselle alalle. Optikkoliikkeiden tarve tarjota entistä enemmän palveluita kasvaa lähivuosina. Optikon toimenkuva silmän terveydentilan tutkijana tulee korostumaan ja tämän seurauksena on suunnattava enemmän voimavaroja koulutukseen ja ammattiosaamisen ylläpitämiseen. Optikko on laillistettu terveydenhuollon ammattihenkilö, jolla on lain velvoite ylläpitää asiakastyössä tarvittavaa ammattiosaamista. Opinnäytetyönämme suunnitteli...

  17. Calysolins I-IV, resin glycosides from Calystegia soldanella. (United States)

    Takigawa, Ayako; Muto, Haruka; Kabata, Kiyotaka; Okawa, Masafumi; Kinjo, Junei; Yoshimitsu, Hitoshi; Nohara, Toshihiro; Ono, Masateru


    Four new resin glycosides having intramolecular cyclic ester structures (jalapins), named calysolins I-IV (1-4), were isolated from the methanol extract of leaves, stems, and roots of Calystegia soldanella , along with one known jalapin (5) derivative. The structures of 1-4 were determined on the basis of spectroscopic data and chemical evidence. They fall into two types, one having a 22-membered ring (1 and 4) and the other with a 27-membered ring (2 and 3). The sugar moieties of 1-4 were partially acylated by some organic acids. Compound 4 is the first example of a hexaglycoside of jalapin.

  18. VIP interview: John D. (Jay) Rockefeller IV, United States Senator. (United States)

    Rockefeller, J D


    John D. (Jay) Rockefeller IV has proudly served the people of West Virginia for nearly 30 years. After coming to the town of Emmons in 1964 as a VISTA worker, Jay Rockefeller made the Mountain State his home. In 1966, he was elected to a two-year term in the West Virginia House of Delegates. He then served four years as Secretary of State, three years as President of West Virginia Wesleyan College, and eight years as Governor of West Virginia. In 1984, he was elected to the United States Senate and was reelected in 1990.

  19. Apollonius de Perges, Coniques tome 2.2, livre IV

    CERN Document Server

    Rashed, Roshdi


    Book IV of the Konika consists of two parts; the first presents a theory of poles and polars, the second deals with the number of intersections and points of contact in a conic section. Previously the book was only extant as the very unreliable text of a Greek commentary by Eutocius. Roshdi Rashed here presents for the first time an edition of an Arabic translation based on a text independent of this Greek version. This is a valuable re-discovery, for which reason it is published here as a separate volume. It contains an edition princeps of the Arabic text, together with a faithful translation

  20. Terra e terror em Phase IV, de Saul Bass


    Juliana Fausto


    Os anos 1970 foram palco de uma onda de filmes do gênero eco-horror, dos quais se destaca Phase IV (1974), único longa-metragem dirigido por Saul Bass. O filme é tomado no artigo como um experimento diante da interpelação de povos não-humanos, no caso, as formigas, à humanidade, representada pelo discurso científico. Tendo em vista a atual catástrofe ambiental, propõe-se que o cinema seja um lugar privilegiado para o desenvolvimento de um aparato mítico-real capaz de lidar com o fim do mundo ...

  1. Angiotensin IV possibly acts through PKMzeta in the hippocampus to regulate cognitive memory in rats. (United States)

    Chow, Lok-Hi; Tao, Pao-Luh; Chen, Yuan-Hao; Lin, Yu-Hui; Huang, Eagle Yi-Kung


    Ang IV is an endogenous peptide generated from the degradation of angiotensin II. Ang IV was found to enhance learning and memory in CNS. PKMzeta was identified to be a fragment of PKCzeta (protein kinase Czeta). Its continuous activation was demonstrated to be correlated with the formation of memory in the hippocampus. Therefore, we investigated whether PKMzeta participates in the effects of Ang IV on memory. We first examined the effect of Ang IV on non-spatial memory/cognition in modified object recognition test in rats. Our data showed that Ang IV could increase the exploration time on novel object. The co-administration of ZIP (PKMzeta inhibitor) with Ang IV significantly blocked the effect by Ang IV. The effects of Ang IV on hippocampal LTP at the CA1 region were also evaluated. Ang IV significantly increased the amplitude and slope of the EPSPs, which was consistent with other reports. Surprisingly, instead of potentiating LTP, Ang IV caused a failed maintenance of LTP. Moreover, there was no quantitative change in PKMzeta induced by Ang IV and/or ZIP after behavioral experiments. Taken together, our data re-confirmed the finding of the positive effect of Ang IV to enhance memory/cognition. The increased strength of EPSPs with Ang IV could also have certain functional relevance. Since the behavioral results suggested the involvement of PKMzeta, we hypothesized that the enhancement of memory/cognition by Ang IV may rely on an increase in PKMzeta activity. Overall, the present study provided important advances in our understanding of the action of Ang IV in the hippocampus. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Shape and assembly of type IV procollagen obtained from cell culture.


    Oberbäumer, I; Wiedemann, H.; Timpl, R; Kühn, K


    Type IV procollagen was isolated from the culture medium of the teratocarcinoma cell line PYS-2 by affinity chromatography on heparin-Sepharose. Immunological studies showed that type IV procollagen is composed of pro-alpha 1(IV) and pro-alpha 2(IV) chains and contains two potential cross-linking sites which are located in the short triple-helical 7S domain and the globular domain NC1 . The 7S domain was also identified as the heparin binding site. Rotary shadowing visualized type IV procolla...

  3. Iisalmelaisten vanhempien kokemuksia osallisuudestaan lastensa päivähoitoon


    Rieppo, Niina; Valta, Paula


    Opinnäytetyössä tutkittiin iisalmelaisten vanhempien kokemuksia osallisuudestaan lastensa päivähoitoon. Tarkoituksena oli saada tietoa päivähoidon toteutumisesta vanhempien osallisuuden näkökulmasta. Tavoitteena oli selvittää kuinka vanhemmat kokevat osallisuutensa lastensa päivähoitoon ja vaikuttaako päivähoitomuoto vanhempien kokemuksiin. Tutkimustulosten myötä toimeksiantaja saa tilannekartoituksen vanhempien osallisuuden kokemuksista ja ehdotuksista, joita voidaan käyttää päivähoidon kehi...

  4. Palmar spiny keratoderma associated with type IV hyperlipoproteinemia. (United States)

    Urbani, C E; Moneghini, L


    We report the case of a 35-year-old man with acquired palmar spiny keratoderma (SK) in association with type IV hyperlipoproteinemia. Cutaneous lesions appeared 11 years before with no history of any previous skin conditions, topical medication or systemic treatment with Vitamin A-derived drugs, x-irradiation, arsenic poisoning or prolonged sun exposure. Family aggregation for SK or other disorders of keratinization was ruled out. Blood chemistries demonstrated hypertriglyceridemia (422 mg/dl) and elevation in plasma concentration of the pre-beta fraction (VLDL) of lipoproteins pattern compatible with a type IV hyperlipoproteinemia. Family aggregation for this metabolic defect was then confirmed. The histologic hallmark of the 'spine' lesion was a compact column of hyperparakeratotic cells (columnar hyperparakeratosis) continuous with a hypogranular layer, without further evidence of dyskeratotic or vacuolated keratinocytes and inflammatory cells in the corresponding dermis. SK represents a well-definite entity which fulfills precise clinico-histologic criteria. However, three main questions are related to SK: differential diagnosis with porokeratosis on histologic examination (columnar hyperparakeratosis or hyperorthokeratosis alone in SK vs. cornoid lamella accompanied by remarkable dermoepidermal changes in porokeratosis); classificative scheme (proper nomenclature to avoid misleading and confounding names); and nosological arrangement (probably two subsets exist: hereditary or benign; and acquired, or idiopathic, which may be paraneoplastic in about 50% of the patients). To the best of our knowledge this is the first case reporting the association between SK and a metabolic impairment although the real connections linking these conditions are still unclear.


    Directory of Open Access Journals (Sweden)

    Muhammad Lukman Syafii


    Full Text Available ABSTRACT The textbook is designed to serve the basic principles or aspects containing in the medium of instruction. At SDN Kwagean II Loceret Nganjuk, the textbook becomes the most dominant medium in the instructional process. Another problem in the utilization of the textbook, the textbook has not met the feasibility aspect due to the theory, model, students’ need and the improvement of the students’ motivation. Therefore, the developer aims at developing a product of Social Science (IPS instructional package for IV graders of Elementary School to solve the existing problem concerning the textbook at SDN Kwagean II Loceret Nganjuk. Regarding the problems, the developer considers the importance for reorganizing the social science material for the fourth graders of elementary school by designing, trying out and producing it in the form of complete instructional package. The conclusion of the field test done after going through expert analysis, individual and small group tests can be said that the textbook has fulfilled the students’ need even though there are some matters to be revised. It is expected that IPS Textbook for IV graders is able to solve the problems concerning the instructional package development that comply with the theory and learning model, so it can generate a learning source that is proper with the students’ characteristics, assist the students’ learning and create such learning condition that may improve the students’ motivation.

  6. Pengembangan Paket Pembelajaran Ilmu Pengetahuan Sosial Kelas IV SD

    Directory of Open Access Journals (Sweden)

    Mohammad Lukman Syafii


    Full Text Available The textbook is designed to serve the basic principles or aspects containing in the medium of instruction. At SDN Kwagean II Loceret Nganjuk, the textbook becomes the most dominant medium in the instructional process. Another problem in the utilization of the textbook, the textbook has not met the feasibility aspect due to the theory, model, students’ need and the improvement of the students’ motivation. Therefore, the developer aims at developing a product of Social Science (IPS instructional package for IV graders of Elementary School to solve the existing problem concerning the textbook at SDN Kwagean II Loceret Nganjuk. Regarding the problems, the developer considers the importance for reorganizing the social science material for the fourth graders of elementary school by designing, trying out and producing it in the form of complete instructional package. The conclusion of the field test done after going through expert analysis, individual and small group tests can be said that the textbook has fulfilled the students’ need even though there are some matters to be revised. It is expected that IPS Textbook for IV graders is able to solve the problems concerning the instructional package development that comply with the theory and learning model, so it can generate a learning source that is proper with the students’ characteristics, assist the students’ learning and create such learning condition that may improve the students’ motivation.

  7. Impeding 99Tc(IV) mobility in novel waste forms (United States)

    Lee, Mal-Soon; Um, Wooyong; Wang, Guohui; Kruger, Albert A.; Lukens, Wayne W.; Rousseau, Roger; Glezakou, Vassiliki-Alexandra


    Technetium (99Tc) is an abundant, long-lived radioactive fission product whose mobility in the subsurface is largely governed by its oxidation state. Tc immobilization is crucial for radioactive waste management and environmental remediation. Tc(IV) incorporation in spinels has been proposed as a novel method to increase Tc retention in glass waste forms during vitrification. However, experiments under high-temperature and oxic conditions show reoxidation of Tc(IV) to volatile pertechnetate, Tc(VII). Here we examine this problem with ab initio molecular dynamics simulations and propose that, at elevated temperatures, doping with first row transition metal can significantly enhance Tc retention in magnetite in the order Co>Zn>Ni. Experiments with doped spinels at 700 °C provide quantitative confirmation of the theoretical predictions in the same order. This work highlights the power of modern, state-of-the-art simulations to provide essential insights and generate theory-inspired design criteria of complex materials at elevated temperatures.

  8. Audiological findings in children with mucopolysaccharidoses type i-iv. (United States)

    Vargas-Gamarra, María F; de Paula-Vernetta, Carlos; Vitoria Miñana, Isidro; Ibañez-Alcañiz, Isabel; Cavallé-Garrido, Laura; Alamar-Velazquez, Agustín

    The aim of our study is to reflect hearing impairment of 23children diagnosed with mucopolysaccharidosis (MPS) typeI, II, III and IV. Retrospective study of the clinical, audiological and treatment (medical vs surgical) findings of 23children diagnosed with MPS typeI, II, III or IV followed at a Tertiary Referral Hospital between 1997 and 2015. Six cases of MPSI, 8 of MPSII, 4 of MPSIII and 5 of MPSIV were reviewed. 71.2% of patients had secretory otitis media (SOM) and 54% of patients had some type of hearing loss (HL). The behaviour of hearing loss was variable in each of the subgroups of MPS, finding greater involvement and variability in typesI and II. Children with MPS have a high risk of hearing loss. A significant percentage of transmissive HL progressing to mixed or sensorineural HL was observed. This was more common in typesI and II. Periodic follow up of these patients is mandatory because of hearing impairment and consequences for their development and quality of life. Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Otorrinolaringología y Cirugía de Cabeza y Cuello. All rights reserved.

  9. Usefulness of WISC-IV in Determining Intellectual Giftedness. (United States)

    Molinero, Clara; Mata, Sara; Calero, M Dolores; García-Martín, M Belén; Araque-Cuenca, Arsenio


    Several studies question the usefulness of the Wechsler Intelligence Scale for Children (WISC-IV) in determining giftedness due to the importance of speed in some of its subtests, which may penalize children of high intellectual level. This study analyzes the factor structure of the WISC-IV of gifted children based on confirmatory factor analysis. Participants were eighty-seven gifted children from Spain (6-13 years old). Score discrepancies were also examined for the main indexes: Verbal Comprehension, Processing Speed, Working Memory and Perceptual Organization. Results pointed out four models with a good fit from the five models analyzed: a two-factor model according to GAI subscales (RMSEA = .001, p = .84), a four-factor first-order model including main indexes (RMSEA = .05, p = .19), a four-factor model with g as a direct factor (RMSEA = .001, p = .84) and a four-factor model with g as an indirect higher-order factor (RMSEA = .05, p = .13). Discrepancies were found between Verbal Comprehension and Processing Speed, and between Perceptual Organization and Processing Speed. Verbal Comprehension yielded the highest score, whereas the lowest scores were obtained in Processing Speed and Working Memory. These results support the use of this scale in the assessment and diagnosis of Spanish children with a high intellectual level.

  10. Synthesis and Properties of Group IV Graphane Analogues (United States)

    Goldberger, Joshua

    Similar to how carbon networks can be sculpted into low-dimensional allotropes such as fullerenes, nanotubes, and graphene with fundamentally different properties, it is possible to create similar ligand terminated sp3-hybridized honeycomb graphane derivatives containing Ge or Sn that feature unique and tunable properties. Here, we will describe our recent success in the creation of hydrogen and organic-terminated group IV graphane analogues, from the topochemical deintercalation of precursor Zintl phases, such as CaGe2. We will discuss how the optical, electronic, and thermal properties of these materials can be systematically controlled by substituting either the surface ligand or via alloying with other Group IV elements. Additionally, we have also developed an epitopotaxial approach for integrating precise thicknesses of germanane layers onto Ge wafers that combines the epitaxial deposition of CaGe2 precursor phases with the topotactic interconversion into the 2D material. Finally, we will describe our recent efforts on the synthesis and crystal structures of Sn-containing graphane alloys in order to access novel topological phenomena predicted to occur in these graphanes.

  11. Analytical modeling of PEM fuel cell i-V curve

    Energy Technology Data Exchange (ETDEWEB)

    Haji, Shaker [College of Engineering, Department of Chemical Engineering, University of Bahrain, P.O. Box 32038 (Bahrain)


    The performance of a fuel cell is characterized by its i-V curve. In this study, the performance of a bench scale fuel cell stack, run on hydrogen/air, is measured experimentally for different air flow rates and temperatures. The experimental data, obtained from the 40-W proton exchange membrane fuel cell (PEMFC), are used in estimating the parameters of a completely analytical model that describes the i-V curve. The analytical model consists of the three fundamental losses experienced by a fuel cell, namely: activation, ohmic, and concentration losses. The current loss is also considered in the model. While the Tafel constants, ohmic resistance, and the concentration loss constant are estimated through regression, the limiting current density and the current loss are obtained through measurements. The effect of temperature on the fuel cell performance, exchange current density, and current loss is also investigated. Both the exchange current density and the current loss are plotted against temperature on an Arrhenius-like plot and the related parameters are estimated. The theoretical equations derived in the literature, which model fuel cell performance, are found to reasonably fit the obtained experimental data. (author)

  12. Named entity recognition for bacterial Type IV secretion systems.

    Directory of Open Access Journals (Sweden)

    Sophia Ananiadou


    Full Text Available Research on specialized biological systems is often hampered by a lack of consistent terminology, especially across species. In bacterial Type IV secretion systems genes within one set of orthologs may have over a dozen different names. Classifying research publications based on biological processes, cellular components, molecular functions, and microorganism species should improve the precision and recall of literature searches allowing researchers to keep up with the exponentially growing literature, through resources such as the Pathosystems Resource Integration Center (PATRIC, We developed named entity recognition (NER tools for four entities related to Type IV secretion systems: 1 bacteria names, 2 biological processes, 3 molecular functions, and 4 cellular components. These four entities are important to pathogenesis and virulence research but have received less attention than other entities, e.g., genes and proteins. Based on an annotated corpus, large domain terminological resources, and machine learning techniques, we developed recognizers for these entities. High accuracy rates (>80% are achieved for bacteria, biological processes, and molecular function. Contrastive experiments highlighted the effectiveness of alternate recognition strategies; results of term extraction on contrasting document sets demonstrated the utility of these classes for identifying T4SS-related documents.

  13. Identification and characterization of a dipeptidyl peptidase IV inhibitor from aronia juice

    Energy Technology Data Exchange (ETDEWEB)

    Kozuka, Miyuki [Department of Health and Nutrition, Faculty of Human Science, Hokkaido Bunkyo University, Eniwa 061-1449 (Japan); Yamane, Takuya, E-mail: [Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812 (Japan); Nakano, Yoshihisa [Center for Research and Development Bioresources, Research Organization for University-Community Collaborations, Osaka Prefecture University, Sakai, Osaka 599-8570 (Japan); Nakagaki, Takenori [Institute of Food Sciences, Nakagaki Consulting Engineer Co., Ltd, Nishi-ku, Sakai 593-8328 (Japan); Ohkubo, Iwao [Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Higashi-ku, Sapporo 065-0013 (Japan); Ariga, Hiroyoshi [Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812 (Japan)


    Aronia berries have many potential effects on health, including an antioxidant effect, effect for antimutagenesis, hepatoprotection and cardioprotection, an antidiabetic effect and inhibition of cancer cell proliferation. Previous human studies have shown that aronia juice may be useful for treatment of obesity disorders. In this study, we found that aronia juice has an inhibitory effect against dipeptidyl peptidase IV (DPP IV) (EC DPP IV is a peptidase that cleaves the N-terminal region of incretins such as glucagon-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). Inactivation of incretins by DPP IV induces reduction of insulin secretion. Furthermore, we identified that cyanidin 3, 5-diglucoside as the DPP IV inhibitor in aronia juice. DPP IV was inhibited more strongly by cyanidin 3, 5-diglucoside than by cyanidin and cyanidin 3-glucoside. The results suggest that DPP IV is inhibited by cyanidin 3, 5-diglucoside present in aronia juice. The antidiabetic effect of aronia juice may be mediated through DPP IV inhibition by cyanidin 3, 5-diglucoside. - Highlights: • DPP IV activity is inhibited by aronia juice. • DPP IV inhibitor is cyanidin 3, 5-diglucoside in aronia juice. • DPP IV is inhibited by cyanidin 3, 5-diglucoside more than cyanidin and cyanidin 3-glucoside.


    Directory of Open Access Journals (Sweden)

    Diana Rakhmawaty Eddy


    Full Text Available Pada penelitian ini telah dilakukan fotodegradasi pestisida jenis sipermetrin dengan adanya fotokatalis titanium (IV oksida-platina. Fotokatalis tersebut dibuat dengan merefluks larutan titanium(IV oksida tetraminplatina(II klorida selama 2 jam kemudian diuapkan pelarutnya dan dipanaskan selama 12 jam. Padatan fotokatalis kemudian dikalsinasi selama 3 jam pada 500 °C. Hasil sintesis titanium(IV oksida-platina 0,5% dan 1% dikarakterisasi dengan XRD, SEM, dan SEM-EDX. Kemampuan dalam mengkatalisis fotodegradasi diuji untuk pestisida sipermetrin yang dilakukan selama 4 jam. Hasil fotodegradasi dinyatakan sebagai COD (Chemical Oxygen Demand yang diukur setiap 1 jam. Penurunan COD terbesar untuk titanium(IV oksida platina 0,5% dan titanium(IV oksida-platina 1% masing-masing yaitu 77% dan 79%. Sementara TiO2 standar sebesar 68,42 %. Fotokatalis titanium(IV oksida-platina lebih baik dibanding titanium(IV oksida untuk degradasi sipermetrin.

  15. The I-V Measurement System for Solar Cells Based on MCU

    Energy Technology Data Exchange (ETDEWEB)

    Chen Fengxiang; Ai Yu; Wang Jiafu; Wang Lisheng, E-mail: [Department of physics science and technology, Wuhan University of Technology, Wuhan city, Hubei Province, 430070 (China)


    In this paper, an I-V measurement system for solar cells based on Single-chip Microcomputer (MCU) is presented. According to the test principles of solar cells, this measurement system mainly comprises of two parts-data collecting, data processing and displaying. The MCU mainly used as to acquire data, then the collecting results is sent to the computer by serial port. The I-V measurement results of our test system are shown in the human-computer interaction interface based on our hardware circuit. By comparing the test results of our I-V tester and the results of other commercial I-V tester, we found errors for most parameters are less than 5%, which shows our I-V test result is reliable. Because the MCU can be applied in many fields, this I-V measurement system offers a simple prototype for portable I-V tester for solar cells.

  16. Development of alternate paragraphs for the Logical Memory subtest of the Wechsler Memory Scale-IV. (United States)

    Morris, Jeri; Swier-Vosnos, Amy; Woodworth, Craig; Umfleet, Laura Glass; Czipri, Sheena; Kopald, Brandon


    The purpose of the two studies included in this article was to validate an alternate form, the Morris Revision-Fourth Edition (MR-IV), to the Logical Memory paragraphs of the Wechsler Memory Scale-Fourth Edition (LM-IV) for use when retesting of individuals is desired. Study I demonstrated high correlation with the LM-IV paragraphs. Study II was a replication that again demonstrated high correlation between the original LM-IV and the new MR-IV paragraphs. High interrater reliability also was demonstrated. Consequently, the MR-IV paragraphs can be considered an alternate form to the LM-IV paragraphs. Although other attempts have been made to develop alternate stories, these new paragraphs are the only ones that are equivalent in structure, affective tone, and number of scorable units. They have considerable clinical utility and research potential.

  17. The dependence of C IV broad absorption line properties on accompanying Si IV and Al III absorption: relating quasar-wind ionization levels, kinematics, and column densities

    Energy Technology Data Exchange (ETDEWEB)

    Filiz Ak, N.; Brandt, W. N.; Schneider, D. P.; Trump, J. R. [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States); Hall, P. B. [Department of Physics and Astronomy, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3 (Canada); Anderson, S. F. [Astronomy Department, University of Washington, Seattle, WA 98195 (United States); Hamann, F. [Department of Astronomy, University of Florida, Gainesville, FL 32611-2055 (United States); Myers, Adam D. [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82071 (United States); Pâris, I. [Departamento de Astronomía, Universidad de Chile, Casilla 36-D, Santiago (Chile); Petitjean, P. [Institut d' Astrophysique de Paris, Universite Paris 6, F-75014 Paris (France); Ross, Nicholas P. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Shen, Yue [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); York, Don, E-mail: [Department of Astronomy and Astrophysics, The University of Chicago, Chicago, IL 60637 (United States)


    We consider how the profile and multi-year variability properties of a large sample of C IV Broad Absorption Line (BAL) troughs change when BALs from Si IV and/or Al III are present at corresponding velocities, indicating that the line of sight intercepts at least some lower ionization gas. We derive a number of observational results for C IV BALs separated according to the presence or absence of accompanying lower ionization transitions, including measurements of composite profile shapes, equivalent width (EW), characteristic velocities, composite variation profiles, and EW variability. We also measure the correlations between EW and fractional-EW variability for C IV, Si IV, and Al III. Our measurements reveal the basic correlated changes between ionization level, kinematics, and column density expected in accretion-disk wind models; e.g., lines of sight including lower ionization material generally show deeper and broader C IV troughs that have smaller minimum velocities and that are less variable. Many C IV BALs with no accompanying Si IV or Al III BALs may have only mild or no saturation.

  18. Particulate emissions from new heavy duty vehicles (Euro IV and V); Partikeludslip fra nye tunge koeretoejer (Euronorm IV og V)

    Energy Technology Data Exchange (ETDEWEB)

    Jordal-Joergensen, J.; Ohm, A.; Willumsen, E. (COWI A/S, Kgs. Lyngby (DK))


    The new Danish act on environmental zones allows local authorities to define zones where EURO III or older heavy duty vehicles should be equipped with a particulate filter. The introduction of EURO IV and V has reduced particulate emissions from heavy duty vehicles by approximately 80 % based on the mass of particles. There is, however, substantial uncertainty about the impact on the number of ultrafine particles, since they are not covered by Euronorm standards. When passing the bill, the Danish Minister for the Environment of the time stated that all relevant knowledge about particle emission from heavy duty vehicles needed to be collected for subsequent publication. To this end, the Danish Environmental Protection Agency (DEPA) commissioned a literature survey. The purpose of the survey is to provide an overview of the latest knowledge in the field of particle emissions from heavy duty vehicles, with special focus on the average size of the particle emissions. Another objective of the study is to analyse the direct emissions of NO{sub 2} from heavy duty vehicles classified under EURO IV and V. (au)

  19. Genome wide identification and expression analysis of Homeodomain leucine zipper subfamily IV (HDZ IV gene family from Musa accuminata

    Directory of Open Access Journals (Sweden)

    Ashutosh ePandey


    Full Text Available The homedodomain zipper family (HD-ZIP of transcription factors is present only in plants and plays important role in the regulation of plant-specific processes. The subfamily IV of HDZ transcription factors (HD-ZIP IV has primarily been implicated in the regulation of epidermal structure development. Though this gene family is present in all lineages of land plants, members of this gene family have not been identified in banana, which is one of the major staple fruit crops. In the present work, we identified 21 HDZIV genes in banana by the computational analysis of banana genome resource. Our analysis suggested that these genes putatively encode proteins having all the characteristic domains of HDZIV transcription factors. The phylogenetic analysis of the banana HDZIV family genes further confirmed that after separation from a common ancestor, the banana and poales lineages might have followed distinct evolutionary paths. Further, we conclude that segmental duplication played a major role in the evolution of banana HDZIV genes. All the identified banana HDZIV genes expresses in different banana tissue, however at varying levels. The transcript levels of some of the banana HDZIV genes were also detected in banana fruit pulp, suggesting their putative role in fruit attributes. A large number of genes of this family showed modulated expression under drought and salinity stress. Taken together, the present work lays a foundation for elucidation of functional aspects of the banana HDZIV genes and for their possible use in the banana improvement programs.

  20. Time in Physics IV: Aristotle's reductionistic vision in four movements (United States)

    Roark, Anthony Phillip

    Aristotle's definition of time in Physics IV.11 as ``a number of motion with respect to the before and after'' is often claimed to be viciously circular, since it is thought that `before' and `after' are terms that cannot be explicated independently of temporal concepts. My project in this dissertation is to defend Aristotle's theory against this charge of circularity and, further, to argue that it succeeds where some modern theories of time fail. The centerpiece of my interpretation is an explication of theoretical entities that Aristotle calls `the before and after in motion', entities that I have dubbed `kinetic positions'. Kinetic positions are instantaneous happenings within a movement that can be specified as functions of a moving object's actual spatial location and the telos, or end, of the movement. On Aristotle's view, time is an aspect of motion, and kinetic positions are the lower-level metaphysical counterparts of instants. It is in this sense that Aristotle's account is reductionistic: time derives its existence and structure from that of motion, and motion derives its existence and structure from that of spatial magnitudes. The success of my project requires that I: (i)establish that Aristotle's kinetic theory can be explicated independently of temporal concepts; (ii)explain how the asymmetrically-ordered kinetic continuum derives from the symmetrically-ordered spatial continuum; (iii)show that my interpretation of kinetic positions is consistent with Aristotle's claim in Physics VI that motion in an instant is impossible; (iv)explain the significance of Aristotle's placement of time within the genus number; (v)justify Aristotle's claim in IV.14 that time would not exist if there were no perceptive souls; (vi)how that Aristotle's account integrates temporal passage, the ``flow'' of time, in such a way as to be immune from devastating arguments, devised by McTaggart and others, against its possibility. I conclude that Aristotle ultimately conceives

  1. IV Magnesium Sulfate for Bronchiolitis: A Randomized Trial. (United States)

    Alansari, Khalid; Sayyed, Rafah; Davidson, Bruce L; Al Jawala, Shahaza; Ghadier, Mohamed


    The goal of this study was to determine if IV magnesium, useful for severe pediatric asthma, reduces time to medical readiness for discharge in patients with bronchiolitis when added to supportive care. We compared a single dose of 100 mg/kg of IV magnesium sulfate vs placebo for acute bronchiolitis. Patients received bronchodilator therapy, nebulized hypertonic saline, and 5 days of dexamethasone if there was eczema and/or a family history of asthma. Time to medical readiness for discharge was the primary efficacy outcome. Bronchiolitis severity scores and need for infirmary or hospital admission and for clinic revisits within 2 weeks were secondary outcomes. Cardiorespiratory instability onset was the safety outcome. A total of 162 previously healthy infants diagnosed with bronchiolitis aged 22 days to 17.6 months (median, 3.7 months) were enrolled. Approximately one-half of patients had eczema and/or a family history of asthma; 86.4% had positive findings on nasopharyngeal virus swabs. Geometric mean time until medical readiness for discharge was 24.1 h (95% CI, 20.0-29.1) for the 78 magnesium-treated patients and 25.3 h (95% CI, 20.3-31.5) for the 82 patients receiving placebo (ratio, 0.95 [95% CI, 0.52-1.80]; P = .91). Mean bronchiolitis severity scores over time were similar for the two groups. The frequency of clinic visits in the subsequent 2 weeks (33.8% and 27.2%, respectively) was also similar. Fifteen magnesium recipients (19.5%) vs five placebo recipients (6.2%) were readmitted to the infirmary or hospital within 2 weeks (P = .016). No acute cardiorespiratory side effects were reported. IV magnesium did not provide benefit for patients with acute bronchiolitis and may be harmful.; No.: NCT02145520; URL: Copyright © 2017 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

  2. Organic / IV, III-V semiconductor hybrid solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Ong, P.-L. [Emitech, Inc., Fall River, Massachusetts, 02720 (United States); Levitsky, I. A. [Emitech, Inc., Fall River, Massachusetts, 02720 (United States); Department of Chemistry, University of Rhode Island, Kingston, Rhode Island, 02881 (United States)


    We present a review of the emerging class of hybrid solar cells based on organic-semiconductor (Group IV, III-V), nanocomposites, which states separately from dye synthesized, polymer-metal oxides and organic-inorganic (Group II-VI) nanocomposite photovoltaics. The structure of such hybrid cell comprises of an organic active material (p-type) deposited by coating, printing or spraying technique on the surface of bulk or nanostructured semiconductor (n-type) forming a heterojunction between the two materials. Organic components include various photosensitive monomers (e.g., phtalocyanines or porphyrines), conjugated polymers, and carbon nanotubes. Mechanisms of the charge separation at the interface and their transport are discussed. Also, perspectives on the future development of such hybrid cells and comparative analysis with other classes of photovoltaics of third generation are presented. (author)

  3. Organic / IV, III-V Semiconductor Hybrid Solar Cells

    Directory of Open Access Journals (Sweden)

    Pang-Leen Ong


    Full Text Available We present a review of the emerging class of hybrid solar cells based on organic-semiconductor (Group IV, III-V, nanocomposites, which states separately from dye synthesized, polymer-metal oxides and organic-inorganic (Group II-VI nanocomposite photovoltaics. The structure of such hybrid cell comprises of an organic active material (p-type deposited by coating, printing or spraying technique on the surface of bulk or nanostructured semiconductor (n-type forming a heterojunction between the two materials. Organic components include various photosensitive monomers (e.g., phtalocyanines or porphyrines, conjugated polymers, and carbon nanotubes. Mechanisms of the charge separation at the interface and their transport are discussed. Also, perspectives on the future development of such hybrid cells and comparative analysis with other classes of photovoltaics of third generation are presented.

  4. CRR/CRD IV: the trees and the forest

    Directory of Open Access Journals (Sweden)

    Rainer Masera


    Full Text Available This paper offers a review of the new CRR/CRD IV capital regulatory framework for banks in the EU, which represents the transposition into European law of the Basel III standard. Major shortcomings of the Second Capital Accord are examined, and the repair work is assessed in the light of the recognised need to amend the flaws. It is argued that the necessary adjustments must be evaluated in the holistic framework provided by the Banking Union approach. The main features of the new system are reviewed as components of an interconnected, complex network. The critical analysis highlights the significant improvements with respect to the Basel II standard, but it also brings to the fore the weaknesses which continue to characterise the new capital regulatory framework.

  5. Automation Of An I-V Characterization System

    Directory of Open Access Journals (Sweden)

    J. R. Noriega


    Full Text Available In this paper, an accurate I-V virtual instrument (VI that has been developed to characterize electronic devices forresearch and teaching purposes is demonstrated. The virtual instrument can be used to highlight principles ofmeasurement, instrumentation, fundamental principles of electronics, VI programming, device testing andcharacterization in wafer or discrete device level. It consists of a Keithley electrometer, model 6514, a programmablepower supply BK Precision, model 1770, a Keithley source meter, model 2400-LV, an Agilent digital multimeter, model34401, a PC computer and LabVIEW software. The instruments are interconnected using an IEEE 488 protocol. Thecharacteristic VI devices graphs are generated from measured data previous computational processing. Theinstrument is used in basic courses of physical electronics as well as in advance curses of VLSI design and inresearch work for characterization of semiconductor materials and devices. This paper describes the VI instrumentdesign, implementation and characterization experiments.

  6. ACME-III and ACME-IV Final Campaign Reports

    Energy Technology Data Exchange (ETDEWEB)

    Biraud, S. C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)


    The goals of the Atmospheric Radiation Measurement (ARM) Climate Research Facility’s third and fourth Airborne Carbon Measurements (ACME) field campaigns, ACME-III and ACME-IV, are: 1) to measure and model the exchange of CO2, water vapor, and other greenhouse gases by the natural, agricultural, and industrial ecosystems of the Southern Great Plains (SGP) region; 2) to develop quantitative approaches to relate these local fluxes to the concentration of greenhouse gases measured at the Central Facility tower and in the atmospheric column above the ARM SGP Central Facility, 3) to develop and test bottom-up measurement and modeling approaches to estimate regional scale carbon balances, and 4) to develop and test inverse modeling approaches to estimate regional scale carbon balance and anthropogenic sources over continental regions. Regular soundings of the atmosphere from near the surface into the mid-troposphere are essential for this research.

  7. Eutrophication levels of some South African impoundments. IV. Vaal Dam

    CSIR Research Space (South Africa)

    Steyn, DJ


    Full Text Available -nt clischargc?cl directly itito tlit- impottnclment_ These vititi t-o,n1iarc lavt,tiralilv with the rc-spccti~ t? valttcs ?or Rietvlci Da (817 and 1-1:3: Stcc-n it of,. 1975a). l-larthitcspoort Darn (7. audI 13,0: Stc~n et of., 19751i) and Rttodcplaat Dam (7...,17 2.4: StcVn it of,, 1975t3, VatI Dam water with thc? addition of ID per cent Iv!?) I?Il was limited tlirottghotit hr tntrogi-n (Fig, 1)_This was also t case hr Rictylci IStcS~u tt (if., 1975:6, Hartliccspoort (Ste5/n TABLE I THE ALGAL GROWTH RATE...

  8. Pyrazine Carboxylic Acid Derivatives of Dichlorobis(Cyclopentadienyltitanium(IV

    Directory of Open Access Journals (Sweden)

    Satish Chandra Dixit


    Full Text Available Reactions of dichlorobis(cyclopentadienyltitanium(IV with pyrazine carboxylic acids viz. 2-pyrazine carboxylic acid (2-PzCH, 5-methyl-2-pyrazine carboxylic acid (MPzCH and 2,3-pyrazine dicarboxylic acid (2,3-PzDCH2 were carried out in different stoichiometric ratios. Complexes of the type Cp2Ti(2-PzCCl , Cp2Ti(2-PzC2 ,Cp2Ti(MPzCCl,Cp2Ti(MPzC2, Cp2Ti(2,3-PzDCHCl and Cp2Ti(2,3-PzDCH2 were obtained. These newly synthesized complexes were characterized on the basis of elemental analyses, electrical conductance, magnetic moment and spectral data.

  9. A structurally characterized organometallic plutonium(IV) complex

    Energy Technology Data Exchange (ETDEWEB)

    Apostolidis, Christos; Walter, Olaf [European Commission, Joint Research Centre, Directorate G - Nuclear Safety and Security, Karlsruhe (Germany); Vogt, Jochen; Liebing, Phil; Edelmann, Frank T. [Chemisches Institut, Otto-von-Guericke-Universitaet Magdeburg (Germany); Maron, Laurent [Laboratoire de Physique et Chimie des Nanoobjets (LPCNO), Universite de Toulouse/INSA/CNRS (UMR5215), Toulouse (France)


    The blood-red plutonocene complex Pu(1,3-COT'')(1,4-COT'') (4; COT''=η{sup 8}-bis(trimethylsilyl)cyclooctatetraenyl) has been synthesized by oxidation of the anionic sandwich complex Li[Pu(1,4-COT''){sub 2}] (3) with anhydrous cobalt(II) chloride. The first crystal structure determination of an organoplutonium(IV) complex revealed an asymmetric sandwich structure for 4 where one COT'' ring is 1,3-substituted while the other retains the original 1,4-substitution pattern. The electronic structure of 4 has been elucidated by a computational study, revealing a probable cause for the unexpected silyl group migration. (copyright 2017 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

  10. Severe type IV hypersensitivity to 'black henna' tattoo. (United States)

    Vasilakis, Vasileios; Knight, Bernice; Lidder, Satnam; Frankton, Sarah


    A 16-year-old Bangladeshi girl presented with a 9-day history of an extensive pruritic, erythematous, papulovesicular skin eruption to both forearms. Appearance was 5 days following application of a home-made henna preparation. Examination revealed ulceration and scabbing along the whole henna pattern and early keloid formation. A diagnosis of type IV delayed hypersensitivity reaction superimposed by infection was initially made. As in this case, home-made henna preparations commonly combine commercial henna with black hair dye, paraphenylenediamine (PPD). PPD, widely known as 'black henna', darkens the pigment and precipitates the drying process. PPD is a potent contact allergen associated with a high incidence of hypersensitivity reactions. Despite treatment the patient was left with extensive keloid scarring in the pattern of the henna tattoo.

  11. Severe type IV hypersensitivity to ‘black henna’ tattoo (United States)

    Vasilakis, Vasileios; Knight, Bernice; Lidder, Satnam; Frankton, Sarah


    A 16-year-old Bangladeshi girl presented with a 9-day history of an extensive pruritic, erythematous, papulovesicular skin eruption to both forearms. Appearance was 5 days following application of a home-made henna preparation. Examination revealed ulceration and scabbing along the whole henna pattern and early keloid formation. A diagnosis of type IV delayed hypersensitivity reaction superimposed by infection was initially made. As in this case, home-made henna preparations commonly combine commercial henna with black hair dye, paraphenylenediamine (PPD). PPD, widely known as ‘black henna’, darkens the pigment and precipitates the drying process. PPD is a potent contact allergen associated with a high incidence of hypersensitivity reactions. Despite treatment the patient was left with extensive keloid scarring in the pattern of the henna tattoo. PMID:22778139

  12. Introduction to The neurosciences and music IV: learning and memory. (United States)

    Altenmüller, E; Demorest, S M; Fujioka, T; Halpern, A R; Hannon, E E; Loui, P; Majno, M; Oechslin, M S; Osborne, N; Overy, K; Palmer, C; Peretz, I; Pfordresher, P Q; Särkämö, T; Wan, C Y; Zatorre, R J


    The conference entitled "The Neurosciences and Music-IV: Learning and Memory'' was held at the University of Edinburgh from June 9-12, 2011, jointly hosted by the Mariani Foundation and the Institute for Music in Human and Social Development, and involving nearly 500 international delegates. Two opening workshops, three large and vibrant poster sessions, and nine invited symposia introduced a diverse range of recent research findings and discussed current research directions. Here, the proceedings are introduced by the workshop and symposia leaders on topics including working with children, rhythm perception, language processing, cultural learning, memory, musical imagery, neural plasticity, stroke rehabilitation, autism, and amusia. The rich diversity of the interdisciplinary research presented suggests that the future of music neuroscience looks both exciting and promising, and that important implications for music rehabilitation and therapy are being discovered. © 2012 New York Academy of Sciences.

  13. Rhodamine 6G hexachloridostannate(IV acetonitrile disolvate

    Directory of Open Access Journals (Sweden)

    Ramaiyer Venkatraman


    Full Text Available In the title compound, bis({6-ethylamino-10-[2-(methoxycarbonylphenyl]-2,7-dimethylxanthen-3-ylidene}ethanaminium hexachloridotin(IV acetonitrile disolvate, (C27H29N2O32[SnCl6]·2C2H3N, the octahedral SnCl62− anion lies on an inversion center. The xanthene ring system is essentially planar, with an average deviation of 0.020 Å, and the substituent benzene ring forms a dihedral angle of 85.89 (2° with it. The Sn—Cl distances are in the range 2.4237 (3–2.4454 (3 Å. There are N—H...Cl hydrogen bonds between SnCl62− ions and rhodamine 6G cations as well as π–π stacking interactions between rhodamine 6G cations (interplanar distance of 3.827 Å.

  14. Adding source positions to the IVS combination—First results (United States)

    Bachmann, Sabine; Thaller, Daniela


    The consistent estimation of terrestrial reference frames (TRF), celestial reference frames (CRF) and Earth orientation parameters (EOP) is still an open subject and offers a large field of investigations. Until now, source positions resulting from Very Long Baseline Interferometry (VLBI) observations are not routinely combined on the level of normal equations in the same way as it is a common process for station coordinates and EOPs. The combination of source positions based on VLBI observations is now integrated in the IVS combination process. We present the studies carried out to evaluate the benefit of the combination compared to individual solutions. On the level of source time series, improved statistics regarding weighted root mean square have been found for the combination in comparison with the individual contributions. In total, 67 stations and 907 sources (including 291 ICRF2 defining sources) are included in the consistently generated CRF and TRF covering 30 years of VLBI contributions. The rotation angles A_1, A_2 and A_3 relative to ICRF2 are -12.7, 51.7 and 1.8 μas, the drifts D_α and D_δ are -67.2 and 19.1 μas/rad and the bias B_δ is 26.1 μas. The comparison of the TRF solution with the IVS routinely combined quarterly TRF solution shows no significant impact on the TRF, when the CRF is estimated consistently with the TRF. The root mean square value of the post-fit station coordinate residuals is 0.9 cm.

  15. Identification of Anaplasma marginale type IV secretion system effector proteins.

    Directory of Open Access Journals (Sweden)

    Svetlana Lockwood

    Full Text Available Anaplasma marginale, an obligate intracellular alphaproteobacterium in the order Rickettsiales, is a tick-borne pathogen and the leading cause of anaplasmosis in cattle worldwide. Complete genome sequencing of A. marginale revealed that it has a type IV secretion system (T4SS. The T4SS is one of seven known types of secretion systems utilized by bacteria, with the type III and IV secretion systems particularly prevalent among pathogenic Gram-negative bacteria. The T4SS is predicted to play an important role in the invasion and pathogenesis of A. marginale by translocating effector proteins across its membrane into eukaryotic target cells. However, T4SS effector proteins have not been identified and tested in the laboratory until now.By combining computational methods with phylogenetic analysis and sequence identity searches, we identified a subset of potential T4SS effectors in A. marginale strain St. Maries and chose six for laboratory testing. Four (AM185, AM470, AM705 [AnkA], and AM1141 of these six proteins were translocated in a T4SS-dependent manner using Legionella pneumophila as a reporter system.The algorithm employed to find T4SS effector proteins in A. marginale identified four such proteins that were verified by laboratory testing. L. pneumophila was shown to work as a model system for A. marginale and thus can be used as a screening tool for A. marginale effector proteins. The first T4SS effector proteins for A. marginale have been identified in this work.

  16. Group IV nanotube transistors for next generation ubiquitous computing

    KAUST Repository

    Fahad, Hossain M.


    Evolution in transistor technology from increasingly large power consuming single gate planar devices to energy efficient multiple gate non-planar ultra-narrow (< 20 nm) fins has enhanced the scaling trend to facilitate doubling performance. However, this performance gain happens at the expense of arraying multiple devices (fins) per operation bit, due to their ultra-narrow dimensions (width) originated limited number of charges to induce appreciable amount of drive current. Additionally arraying degrades device off-state leakage and increases short channel characteristics, resulting in reduced chip level energy-efficiency. In this paper, a novel nanotube device (NTFET) topology based on conventional group IV (Si, SiGe) channel materials is discussed. This device utilizes a core/shell dual gate strategy to capitalize on the volume-inversion properties of an ultra-thin (< 10 nm) group IV nanotube channel to minimize leakage and short channel effects while maximizing performance in an area-efficient manner. It is also shown that the NTFET is capable of providing a higher output drive performance per unit chip area than an array of gate-all-around nanowires, while maintaining the leakage and short channel characteristics similar to that of a single gate-all-around nanowire, the latter being the most superior in terms of electrostatic gate control. In the age of big data and the multitude of devices contributing to the internet of things, the NTFET offers a new transistor topology alternative with maximum benefits from performance-energy efficiency-functionality perspective. © (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

  17. A phase 3 trial of IV immunoglobulin for Alzheimer disease. (United States)

    Relkin, Norman R; Thomas, Ronald G; Rissman, Robert A; Brewer, James B; Rafii, Michael S; van Dyck, Christopher H; Jack, Clifford R; Sano, Mary; Knopman, David S; Raman, Rema; Szabo, Paul; Gelmont, David M; Fritsch, Sandor; Aisen, Paul S


    We tested biweekly infusions of IV immunoglobulin (IVIg) as a possible treatment for mild to moderate Alzheimer disease (AD) dementia. In a phase 3, double-blind, placebo-controlled trial, we randomly assigned 390 participants with mild to moderate AD to receive placebo (low-dose albumin) or IVIg (Gammagard Liquid; Baxalta, Bannockburn, IL) administered IV at doses of 0.2 or 0.4 g/kg every 2 weeks for 18 months. The primary cognitive outcome was change from baseline to 18 months on the 11-item cognitive subscale of the Alzheimer's Disease Assessment Scale; the primary functional outcome was 18-month change on the Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory. Safety and tolerability data, as well as serial MRIs and plasma samples, were collected throughout the study from all enrolled participants. No beneficial effects were observed in the dual primary outcome measures for the 2 IVIg doses tested. Significant decreases in plasma Aβ42 (but not Aβ40) levels were observed in IVIg-treated participants. Analysis of safety data showed no difference between IVIg and placebo in terms of the rate of occurrence of amyloid-related imaging abnormalities (brain edema or microhemorrhage). IVIg-treated participants had more systemic reactions (chills, rashes) but fewer respiratory infections than participants receiving placebo. Participants with mild to moderate AD showed good tolerability of treatment with low-dose human IVIg for 18 months but did not show beneficial effects on cognition or function relative to participants who received placebo. NCT00818662. This study provides Class II evidence that IVIg infusions performed every 2 weeks do not improve cognition or function at 18 months in patients with mild to moderate AD. © 2017 American Academy of Neurology.

  18. Supporting Technology for Enhanced Oil Recovery-EOR Thermal Processes Report IV-12

    Energy Technology Data Exchange (ETDEWEB)

    Izequeido, Alexandor


    This report contains the results of efforts under the six tasks of the Ninth Amendment and Extension of Annex IV, Enhanced Oil Recovery Thermal Processes of the Venezuela/USA Agreement. The report is presented in sections (for each of the 6 tasks) and each section contains one or more reports prepared by various individuals or groups describing the results of efforts under each of the tasks. A statement of each task, taken from the agreement, is presented on the first page of each section. The tasks are numbered 62 through 67. The first, second, third, fourth, fifth, sixth, seventh, eight, and ninth reports on Annex IV, [Venezuela MEM/USA-DOE Fossil Energy Report IV-1, IV-2, IV-3, IV-4, IV-5, IV-6, IV-7, and IV-8 (DOE/BETC/SP-83/15, DOE/BC-84/6/SP, DOE/BC-86/2/SP, DOE/BC-87/2/SP, DOE/BC-89/1/SP, DOE/BC-90/1/SP) DOE/BC-92/1/SP, DOE/BC-93/3/SP, and DOE/BC-95/3/SP] contain the results from the first 61 tasks. Those reports are dated April 1983, August 1984, March 1986, July 1! 987, November 1988, December 1989, October 1991, February 1993, and March 1995 respectively.

  19. Long-term risk of complications after mid-urethral sling IVS implantation

    Directory of Open Access Journals (Sweden)

    Grzegorz Surkont


    Full Text Available [b]Introduction[/b]. Results of short-term evaluation of multifilament microporous midurethral tape IVS differ a great deal. During the first year of implantation, erosions have been observed in 0%–26% of operated women. Long-term observations are rare. They suggest high risk of extrusion and infection even after years of implantation. [b]Objective[/b]. The purpose of the study was to evaluate long-term risk of complications after IVS implantation. Material and methods. Between 2001–2005, 72 women were operated on with the use of IVS mid-urethral tape. [b]Results[/b]. Two women had vaginal erosions during the first 3 months after the operation. Twelve women had vaginal erosions, purulent vaginal discharge, with IVS tape sticking out of the abdominal wall or vagina, and abdominal abscess. These complications were diagnosed between 9 months and 6 years after IVS implantation. The patients were operated on vaginally and open abdominally, 1–5 times because of complications after IVS implantation. [b]Conclusions[/b]. In the case of post-IVS complication, as much tape as possible should be excised. Long-term follow up on patients with IVS implantation should be recommended to the centres where IVS tape was used, even to patients after removal of the tape. Risk of erosion, extrusion and infection after midurethral multifilament microporous IVS tape implantation is too high – which is the reason it should no longer be used.

  20. Facile and reversible formation of iron(III)-oxo-cerium(IV) adducts from nonheme oxoiron(IV) complexes and cerium(III)

    Energy Technology Data Exchange (ETDEWEB)

    Draksharapu, Apparao; Rasheed, Waqas; Klein, Johannes E.M.N.; Que, Lawrence Jr. [Department of Chemistry and Center for Metals in Biocatalysis, University of Minnesota, Minneapolis, MN (United States)


    Ceric ammonium nitrate (CAN) or Ce{sup IV}(NH{sub 4}){sub 2}(NO{sub 3}){sub 6} is often used in artificial water oxidation and generally considered to be an outer-sphere oxidant. Herein we report the spectroscopic and crystallographic characterization of [(N4Py)Fe{sup III}-O-Ce{sup IV}(OH{sub 2})(NO{sub 3}){sub 4}]{sup +} (3), a complex obtained from the reaction of [(N4Py)Fe{sup II}(NCMe)]{sup 2+} with 2 equiv CAN or [(N4Py)Fe{sup IV}=O]{sup 2+} (2) with Ce{sup III}(NO{sub 3}){sub 3} in MeCN. Surprisingly, the formation of 3 is reversible, the position of the equilibrium being dependent on the MeCN/water ratio of the solvent. These results suggest that the Fe{sup IV} and Ce{sup IV} centers have comparable reduction potentials. Moreover, the equilibrium entails a change in iron spin state, from S=1 Fe{sup IV} in 2 to S=5/2 in 3, which is found to be facile despite the formal spin-forbidden nature of this process. This observation suggests that Fe{sup IV}=O complexes may avail of reaction pathways involving multiple spin states having little or no barrier. (copyright 2017 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

  1. Utility of the APACHE IV, PPI, and combined APACHE IV with PPI for predicting overall and disease-specific ICU and ACU mortality. (United States)

    Burkmar, Jennifer A; Iyengar, Rajesh


    The Acute Physiology and Chronic Health Evaluation (APACHE) IV and Palliative Performance Index (PPI) are scales commonly used to assess prognosis in intensive care units (ICUs) and acute care units (ACUs). To compare the utility of APACHE IV, PPI, and combined APACHE IV with PPI for predicting overall and disease-specific mortality. This is a prospective cohort study using admission data during the first 24 hours. Chi-square contingency tables were used to analyze mortality data for each scale. This study was conducted at a community hospital. Participants were admitted between December 24, 2008 and April 2, 2010. The APACHE IV, PPI, and APACHE IV plus PPI (n = 599) were significant for predicting overall mortality (P APACHE IV was also significant in predicting mortality in patients with congestive heart failure (CHF), pulmonary edema (PULEDEM), stroke (cerebrovascular accident [CVA]), terminal or metastatic cancer (CA), and dementia. The PPI was significant for predicting mortality in PULEDEM, CA, and dementia but not CVA or CHF, while the APACHE IV with PPI was significant for all diseases but CVA. The APACHE IV was the most robust in predicting ICU/ACU mortality. The combined APACHE IV and PPI improved the specificity of the PPI to predict mortality but caused a decline in sensitivity. Limitations are due to the subjective nature of the PPI and Glasgow Coma scale (GCS), differences in illness trajectories, and a lack of reliable follow-up of all participants. The benefits of combining scales were best exemplified in participants with dementia. Inconsistencies in the predictive value of specific participant populations are likely due to difference in the illness trajectories of disease processes.

  2. Upgrading a Stage III A engine for Stage IV; Ertuechtigung eines Stufe-III-A-Motors fuer Stufe IV

    Energy Technology Data Exchange (ETDEWEB)

    Schrewe, Klaus; Lamotte, Dominik; Zirka, Ingo [HJS Emission Technology GmbH und Co. KG, Menden (Germany)


    In the field of construction and agricultural machinery proven simple technique is estimated especially in countries with lower development standards as in Central Europe. A 4.4 l, 65 to 95 kW diesel engine that is certified in line with Stage III A, equipped with a fully mechanical injection system and open loop-controlled exhaust-gas recirculation system has now been upgraded from HJS through a low-maintenance and fully autarkic exhaust aftertreatment system that complies with the Stage IV standard. The reduction of nitrogen oxides by selective catalytic reduction is carried out with a NO{sub x} reduction greater than 90 %. The particulate emissions are reduced by a maintenance-free bypass filter with a particle reduction rate exceeds by more than 60 %. (orig.)

  3. "Pieni silta lapsen arkipäivään" : päiväkoti Nuotin osallistavat vanhempaintapahtumat


    Salmenoja-Tümmers, Krista; Tapola, Anna


    Opinnäytetyömme on laadullinen tutkimus, jossa tutkimuskohteena on helsinkiläisen päiväkoti Nuotin vanhempaintapahtumat. Tutkimustehtävämme on toteuttaa kooste Nuotissa ajan saatossa järjestetyistä vanhempaintapahtumista. Tämä kooste on tarkoitus jakaa hyvinä käytäntöinä muiden varhaiskasvatusyksiköiden käyttöön Pääkaupunkiseudun varhaiskasvatuksen kehittämisyksikön, VKK-Metron kautta. Tutkimustehtävämme lisäksi opinnäytetyömme etsii vastauksia tutkimuskysymyksiin, jotka liittyvät vanhempien ...

  4. Preliminary findings on the interactive effects of IV ethanol and IV nicotine on human behavior and cognition: a laboratory study. (United States)

    Ralevski, Elizabeth; Perry, Edward B; D'Souza, D Cyril; Bufis, Vanessa; Elander, Jacqueline; Limoncelli, Diana; Vendetti, Michael; Dean, Erica; Cooper, Thomas B; McKee, Sherry; Petrakis, Ismene


    There are mixed reports on nicotine's effects on alcohol-induced impairment in cognitive performance and behavior in humans. The main objective of this study was to characterize the interactive effects of acute intravenous (IV) alcohol and nicotine administration on behavior and cognition in healthy nonsmokers. Healthy subjects aged 21-44 years participated in 3 test days. On each test day, they received in a double-blind randomized manner one of three IV alcohol infusion conditions using a "clamp": placebo, targeted breathalyzer of 40 mg%, or targeted breathalyzer of 80 mg%. Alcohol infusion was delivered over 20 min and lasted for 120 min. They also received both placebo and active nicotine in a fixed order delivered intravenously. Placebo nicotine was delivered first over 10 min at the timepoint when the breath alcohol was "clamped"; active nicotine (1.0 mcg/kg/min) was delivered for 10 min, 70 min after the alcohol infusion was clamped. Subjective effects of alcohol were measured using the Biphasic Alcohol Effects Scale and the Number of Drinks Scale. Cognitive inhibition and attention were measured by the Continuous Performance Task-Identical Pairs and working memory by the Rey Auditory Verbal Learning Task (RAVLT). Nicotine significantly reversed subjective intoxication and sedation of alcohol at the low dose. Alcohol impaired performance on the RAVLT, and nicotine further impaired verbal learning and recall at both doses of alcohol. The data showed that nicotine had an effect on subjective alcohol effects but did not reverse and actually worsened alcohol-induced deficits in memory.

  5. Explorations of new phases in the Ga(III)/In(III)-Mo(VI)-Se(IV)/Te(IV)-O systems. (United States)

    Kong, Fang; Hu, Chun-Li; Hu, Ting; Zhou, Yong; Mao, Jiang-Gao


    Systematic explorations of new phases in the Ga(III)/In(III)-Mo(VI)-Se(IV)/Te(IV)-O systems by hydrothermal syntheses or solid-state reactions at high-temperature led to four new quaternary compounds, namely, Ga(2)MoQ(2)O(10) (Q = Se, Te), In(2)Mo(2)Se(2)O(13)(H(2)O) and In(2)MoTe(2)O(10). Ga(2)MoQ(2)O(10) (Q = Se, Te) are isostructural and their structures feature a 3D network of gallium selenite/tellurite with 12-member ring tunnels along b-axis, the distorted MoO(6) octahedra are attached on the wall of the above tunnels. The structure of In(2)Mo(2)Se(2)O(13)(H(2)O) features a new pillared-layered architecture composed of 2D indium(III) selenite layers that are interconnected by Mo(2)O(10) dimers, forming 8-membered ring tunnels along the b-axis. The structure of In(2)MoTe(2)O(10) features a 2D indium oxide layer formed by corner- and edge-sharing InO(6) and InO(7) polyhedra with MoO(4) tetrahedra and TeO(n) (n = 4, 5) polyhedra hanging on both sides of the layer, there are weak interlayer Te-O bonds of 2.512 A. Results of optical diffuse reflectance spectrum measurements indicate that all four compounds are insulators, which are in agreement with results of band structure calculations based on DFT methods.

  6. Determination of the solubility of Np(IV), Pu(III) - (VI),Am(III) - (VI), and Te(IV), (V) hydroxo compounds in 0.5 - 14 M NaOH solutions

    Energy Technology Data Exchange (ETDEWEB)

    Delegard, C.H.


    The solubilities of Am(III), Np(IV), Pu(IV), Tc(IV), Np(V), Pu(V), Am(V), and Tc(V) hydroxo compounds were studied in 0.5 to 14 M NaOH solutions at 25{+-}2 {degrees}C. The effects of fluoride, phosphate, carbonate, oxalate, and some other organic complexing agents on the solubilities of Np(IV), Pu(IV), and TC(IV) hydroxides were investigated at 1.0 and 4.0 M NAOH. Some predictions were made on the dissolved (I.V) and (V) species present in alkali solutions.

  7. Vanhempien tyytyväisyys päiväkodin liikuntakasvatukseen : tutkimus Turun Touhula-liikuntapäiväkotien vanhemmille


    Ahosola, Teija


    Tutkimuksellisen opinnäytetyön aihe oli selvittää Turun Touhula-liikuntapäiväkotien vanhempien tyytyväisyyttä ja toiveita liittyen päiväkodin liikuntakasvatukseen kvantitatiivisin tutkimusmenetelmin. Tutkimukseen osallistui kaikki neljä Turun Touhulaa, joiden asiakasperheiden vanhemmille tein kyselymuotoisen tutkimuslomakkeen. Tutkimuskysymysten mukaan tutkimuksessa selvitettiin vanhempien tyytyväisyyttä päiväkodin liikuntakasvatukseen ja liikuntaympäristöön. Tämän lisäksi kartoitettiin vanhe...

  8. 40 CFR Appendix IV to Part 600 - Sample Fuel Economy Labels for 2008 and Later Model Year Vehicles (United States)


    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Sample Fuel Economy Labels for 2008 and Later Model Year Vehicles IV Appendix IV to Part 600 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Pt. 600, App. IV Appendix IV to Part 600...

  9. Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells


    Christie, Peter J.; Vogel, Joseph P.


    Several bacterial pathogens utilize conjugation machines to export effector molecules during infection. Such systems are members of the type IV or ‘adapted conjugation’ secretion family. The prototypical type IV system is the Agrobacterium tumefaciens T-DNA transfer machine, which delivers oncogenic nucleoprotein particles to plant cells. Other pathogens, including Bordetella pertussis, Legionella pneumophila, Brucella spp. and Helicobacter pylori, use type IV machines to export effector prot...

  10. Recombinant expression, refolding, purification and characterization of Pseudomonas aeruginosa protease IV in Escherichia coli. (United States)

    Zhao, Mingzhi; Cai, Man; Wu, Feilin; Zhang, Yao; Xiong, Zhi; Xu, Ping


    Several protease IV enzymes are widely used in proteomic research. Specifically, protease IV from Pseudomonas aeruginosa has lysyl endopeptidase activity. Here, we report the recombinant expression, refolding, activation, and purification of this protease in Escherichia coli. Proteolytic instability of the activated intermediate, a major obstacle for efficient production, is controlled through ammonium sulfate precipitation. The purified protease IV exhibits superior lysyl endopeptidase activity compared to a commercial product. Copyright © 2016. Published by Elsevier Inc.

  11. Generation of Dipeptidyl Peptidase-IV-Inhibiting Peptides from β-Lactoglobulin Secreted by Lactococcus lactis

    Directory of Open Access Journals (Sweden)

    Suguru Shigemori


    Full Text Available Previous studies showed that hydrolysates of β-lactoglobulin (BLG prepared using gastrointestinal proteases strongly inhibit dipeptidyl peptidase-IV (DPP-IV activity in vitro. In this study, we developed a BLG-secreting Lactococcus lactis strain as a delivery vehicle and in situ expression system. Interestingly, trypsin-digested recombinant BLG from L. lactis inhibited DPP-IV activity, suggesting that BLG-secreting L. lactis may be useful in the treatment of type 2 diabetes mellitus.

  12. A Stable Coordination Complex of Rh(IV) in an N,O-Donor Environment

    Energy Technology Data Exchange (ETDEWEB)

    Sinha, Shashi B. [Department of Chemistry, Yale University, 225 Prospect; Shopov, Dimitar Y. [Department of Chemistry, Yale University, 225 Prospect; Sharninghausen, Liam S. [Department of Chemistry, Yale University, 225 Prospect; Vinyard, David J. [Department of Chemistry, Yale University, 225 Prospect; Mercado, Brandon Q. [Department of Chemistry, Yale University, 225 Prospect; Brudvig, Gary W. [Department of Chemistry, Yale University, 225 Prospect; Crabtree, Robert H. [Department of Chemistry, Yale University, 225 Prospect


    We describe facial and meridional isomers of [RhIII(pyalk)3], as well as meridional [RhIV(pyalk)3]+ {pyalk =2-(2-pyridyl)-2-propanoate}, the first coordination complex in an N,O-donor environment to show a clean, reversible RhIII/IV redox couple and to have a stable Rh(IV) form, which we characterize by EPR and UV–visible spectroscopy as well as X-ray crystallography. The unprecedented stability of the Rh(IV) species is ascribed to the exceptional donor strength of the ligands, their oxidation resistance, and the meridional coordination geometry.

  13. Lapsen itsetunnon tukeminen ja vahvistaminen päiväkodissa


    Pessi, Jenna; Lammi, Sonja


    Tarkastelemme opinnäytetyössämme lapsen itsetunnon tukemista ja vahvistamista päiväkodissa. Tutkimuksemme tavoitteena oli selvittää, millä tavoin lapsen itsetunto ja sen tukeminen ja vahvistaminen otetaan huomioon päiväkodin arjessa, ja miten kyseisen päiväkodin kasvattajat kokevat omassa työssään tukevansa ja vahvistavansa lapsen itsetuntoa. Yhteistyökumppaninamme toimi eräs Seinäjoen kaupungin päiväkoti, jossa tutkimus toteutettiin keväällä 2015. Teoriaosuudessa käymme läpi itsetunnon k...

  14. The effect of Paragraph IV decisions and generic entry before patent expiration on brand pharmaceutical firms. (United States)

    Panattoni, Laura E


    This purpose of this paper is to investigate the impact of Paragraph IV patent infringement decisions on brand drug pharmaceutical firms. Paragraph IV decisions determine whether a generic firm can enter before the period of exclusivity ends. I construct a novel dataset of all Paragraph IV decisions and find that they disproportionately involve the highest revenue drugs, significant periods of patent protection, and a non-trivial portion of all brand drugs facing generic entry. I also estimate the impact of Paragraph IV decisions on brand firm profitability and find they have large value consequences. Copyright © 2010 Elsevier B.V. All rights reserved.

  15. Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma (United States)


    Acral Lentiginous Malignant Melanoma; Lentigo Maligna Malignant Melanoma; Nodular Malignant Melanoma; Recurrent Melanoma; Solar Radiation-related Skin Melanoma; Stage IV Melanoma; Superficial Spreading Malignant Melanoma

  16. Pembrolizumab and Ruxolitinib Phosphate in Treating Patients With Metastatic Stage IV Triple Negative Breast Cancer (United States)


    Breast Carcinoma Metastatic in the Bone; Estrogen Receptor Negative; HER2/Neu Negative; Progesterone Receptor Negative; Recurrent Breast Carcinoma; Stage IV Breast Cancer; Triple-Negative Breast Carcinoma

  17. Removal of Se(IV) from aqueous solution using sulphuric acid-treated peanut shell. (United States)

    El-Shafey, E I


    A carbonaceous sorbent was prepared from peanut shell via sulphuric acid treatment. Se(IV) removal from aqueous solution on the sorbent was studied varying time, pH, Se(IV) concentration, temperature and sorbent status (wet and dry). Se(IV) removal was faster using the wet sorbent than the dry sorbent following a pseudo-first-order model. Se(IV) removal increases at low pH values, and decreases as pH increases until pH 7. Sorption was found to fit the Langmuir equation and sorption capacity for the wet sorbent was higher than that for the dry one. Both sorbents showed an increased selenium sorption by rising the temperature. Redox processes between Se(IV) and the carbon sorbent are involved. Analysis by scanning electron microscope and X-ray powder diffraction for the sorbent after the reaction with acidified Se(IV) confirmed the availability of elemental selenium as particles on the sorbent surface as a result of Se(IV) reduction. Physicochemical tests showed an increase in sorbent acidity, cation exchange capacity (CEC) and surface functionality after the reaction with acidified Se(IV), indicating the oxidation processes occurring on the sorbent surface. Due to its reduction properties, the sorbent seems efficient for Se(IV) removal from aqueous solution.

  18. Restauration de la statue de Henri IV

    Directory of Open Access Journals (Sweden)

    Stéphanie Celle


    Full Text Available Cette intervention de conservation du bronze de la statue de Henri IV était la première depuis sa création en 1818 : on héritait de la surface originale de l’œuvre altérée par les vicissitudes du temps et les événements historiques traversés. Le protocole de conservation se voulait respectueux de cette authenticité de la patine et a cherché à en laisser les marques tout en apportant une réponse pour contrer la corrosion active de l’alliage. C’est en conformité aux principes de conservation établis par Cesare Brandi, qu’ont été définis le nettoyage sélectif des surfaces et l’application de couches protectives sur le bronze. Par ailleurs, le moment du chantier est un moment privilégié pour observer un monument et mieux connaître son histoire particulière. Ce chantier nous a permis de redécouvrir deux ensembles de boîtes déposées dans l’antre du cheval dans des situations parfois surprenantes.This conservation treatment for the bronze statue of Henri IV is the first since its creation in 1818. While the original surface of the work remains, it has been altered by natural and human forces; including the weathering of the material from exposure to the elements and damage caused by historic events. The conservation protocol is respectful of this authenticity of the surface patina and the marks of damage due to historical events, while developing a treatment plan to counter the active corrosion of the alloy. In keeping with the principles of conservation established by Cesare Brandi, the treatment program defines the selective cleaning of the surface and the application of several layers of a protective coating on the bronze. In addition, the conservation project is an opportunity to carefully study a monument to better understand its unique history. This project allowed us to rediscover two sets of boxes placed inside the cavity of the horse; an unxpected discovery.

  19. Cyanide vs. azide "magnetic arm wrestling": Mn(II)-Nb(IV) and Mn(II)-Mo(IV) magnetic coordination polymers with mixed bridging. (United States)

    Handzlik, Gabriela; Kozieł, Marcin; Olejniczak, Anna; Sieklucka, Barbara; Pinkowicz, Dawid


    Two magnetic coordination polymers with mixed cyanide-azide bridging based on octacyanoniobate(iv) and octacyanomolybdate(iv) are reported: {(NH4)[(H2O)Mn(II)-(μ-N3)-Mn(II)(H2O)][M(IV)(CN)8]·3H2O}n Mn2MN3 (M = Nb or Mo). Cyanide ligands form the 3-D framework of Mn2MN3, while azide ligands connect two Mn(II) centres together. Both CN(-) and N3(-) are known in magnetochemistry for their marked magnetic coupling abilities which in the case of Mn2NbN3 lead to competitive antiferromagnetic interactions within the Nb(IV)-CN-Mn(II) and Mn(II)-N3-Mn(II) structural motifs. This competition results in a peculiar magnetic behaviour consistent with a non-collinear magnetic structure.

  20. Trypanosoma cruzi strain TcIV infects raccoons from Illinois

    Directory of Open Access Journals (Sweden)

    Cailey Vandermark

    Full Text Available BACKGROUND The northern limits of Trypanosoma cruzi across the territory of the United States remain unknown. The known vectors Triatoma sanguisuga and T. lecticularia find their northernmost limits in Illinois; yet, earlier screenings of those insects did not reveal the presence of the pathogen, which has not been reported in vectors or reservoir hosts in this state. OBJECTIVES Five species of medium-sized mammals were screened for the presence of T. cruzi. METHODS Genomic DNA was isolated from heart, spleen and skeletal muscle of bobcats (Lynx rufus, n = 60, raccoons (Procyon lotor, n = 37, nine-banded armadillos (Dasypus novemcinctus, n = 5, Virginia opossums (Didelphis virginiana, n = 3, and a red fox (Vulpes vulpes. Infections were detected targeting DNA from the kinetoplast DNA minicircle (kDNA and satellite DNA (satDNA. The discrete typing unit (DTU was determined by amplifying two gene regions: the Spliced Leader Intergenic Region (SL, via a multiplex polymerase chain reaction, and the 24Sα ribosomal DNA via a heminested reaction. Resulting sequences were used to calculate their genetic distance against reference DTUs. FINDINGS 18.9% of raccoons were positive for strain TcIV; the rest of mammals tested negative. MAIN CONCLUSIONS These results confirm for the first time the presence of T. cruzi in wildlife from Illinois, suggesting that a sylvatic life cycle is likely to occur in the region. The analyses of sequences of SL suggest that amplicons resulting from a commonly used multiplex reaction may yield non-homologous fragments.

  1. Prediction of survival in patients with Stage IV kidney cancer

    Directory of Open Access Journals (Sweden)

    L. V. Mirilenko


    Full Text Available The efficiency of treatment was evaluated and the predictors of adjusted survival (AS were identified in patients with disseminated kidney cancer treated at the Republican Research and Practical Center for Oncology and Medical Radiology in 1999 to 2011 (A.E. Okeanov, P.I. Moiseev, L.F. Levin. Malignant tumors in Belarus, 2001–2012. Edited by O.G. Sukonko. Seven factors (regional lymph node metastases; distant bone metastases; a high-grade tumor; sarcomatous tumor differentiation; hemoglobin levels of < 125 g/l in women and < 150 g/l in men; an erythrocyte sedimentation rate of 40 mm/h; palliative surgery were found to have an independent, unfavorable impact on AS. A multidimensional model was built to define what risk group low (no more than 2 poor factors, moderate (3–4 poor factors, and high (more than 4 poor factors the patients with Stage IV kidney cancer belonged to. In these groups, the median survival was 34.7, 17.2, and 4.0 months and 3-year AS rates were 48.6, 24.6, and 3.2 %, respectively. 

  2. Factors affecting surgical results of Wassel type IV thumb duplications. (United States)

    Patel, A U C; Tonkin, M A; Smith, B J; Alshehri, A H; Lawson, R D


    The aim of this study is to review the outcomes of Wassel type IV thumb duplications with a minimum of one year follow-up, and to identify any factors that may compromise the quality of results. Forty one patients (42 thumbs) returned for assessment of thumb alignment, metacarpophalangeal joint and interphalangeal joint stability and motion; carpometacarpal joint motion; pinch and grip strengths; and thumb size. The subjective assessment considered thumb shape and contour, scarring, nail deformity and examiner and patient/parent satisfaction. The mean age at surgery was 16 months and the mean follow-up time was 79 months. Metacarpophalangeal joint and interphalangeal joint mal-alignment was present in 56% and 38% of cases, respectively. Interphalangeal ulnar collateral ligament laxity was significant. Metacarpophalangeal joint and interphalangeal joint motion was significantly decreased. Pinch and grip strength measurements were normal. A novel and comprehensive assessment scale is introduced, which revealed results of one (2.5%) excellent, 23 (59%) good, 14 (36%) fair and one (2.5%) poor. We consider that greater attention should be directed to the avoidance of mal-alignment and instability to improve these results. © The Author(s) 2013.

  3. People Are Primary: A Perspective from the Keystone IV Conference. (United States)

    Etz, Rebecca S


    As a person invested in personal doctoring, what promises are you willing to make about when and where you will "be there" for others? Attendees of the G. Gayle Stephens Keystone IV Conference answered that question on submitted index cards and through ongoing conference discussions. Those data were analyzed using grounded theory and combined to develop the following answer in aggregate: We will be held accountable to those who need us. We understand the need for expertise and compassion as we help others to navigate the intersection of science and humanism. We will serve as leaders in personal, public, and political conversations. We will mark a path for the profession ensuring alignment of personal practices with professional principles. We will not allow the needed conversations of processes, data points, and determinations of value to undermine our relationships with our patients. We will be there for you. Attentive and fully present. We will care for you when you have no need and you do not ask. We will center that care in your lived experience of health and illness, knowing you over time. We will be here for you now, over time and across distance, in ways that foster the feeling of wholeness and belonging. We will use the best knowledge, best tailored to meet our shared understanding of your goals and aspirations. © Copyright 2016 by the American Board of Family Medicine.

  4. Role of Mitochondrial Complex IV in Age-Dependent Obesity

    Directory of Open Access Journals (Sweden)

    Ines Soro-Arnaiz


    Full Text Available Aging is associated with progressive white adipose tissue (WAT enlargement initiated early in life, but the molecular mechanisms involved remain unknown. Here we show that mitochondrial complex IV (CIV activity and assembly are already repressed in white adipocytes of middle-aged mice and involve a HIF1A-dependent decline of essential CIV components such as COX5B. At the molecular level, HIF1A binds to the Cox5b proximal promoter and represses its expression. Silencing of Cox5b decreased fatty acid oxidation and promoted intracellular lipid accumulation. Moreover, local in vivo Cox5b silencing in WAT of young mice increased the size of adipocytes, whereas restoration of COX5B expression in aging mice counteracted adipocyte enlargement. An age-dependent reduction in COX5B gene expression was also found in human visceral adipose tissue. Collectively, our findings establish a pivotal role for CIV dysfunction in progressive white adipocyte enlargement during aging, which can be restored to alleviate age-dependent WAT expansion.

  5. An Economic Analysis of Generation IV Small Modular Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, J S; Lamont, A D; Rothwell, G S; Smith, C F; Greenspan, E; Brown, N; Barak, A


    This report examines some conditions necessary for Generation IV Small Modular Reactors (SMRs) to be competitive in the world energy market. The key areas that make nuclear reactors an attractive choice for investors are reviewed, and a cost model based on the ideal conditions is developed. Recommendations are then made based on the output of the cost model and on conditions and tactics that have proven successful in other industries. The Encapsulated Nuclear Heat Source (ENHS), a specific SMR design concept, is used to develop the cost model and complete the analysis because information about the ENHS design is readily available from the University of California at Berkeley Nuclear Engineering Department. However, the cost model can be used to analyze any of the current SMR designs being considered. On the basis of our analysis, we determined that the nuclear power industry can benefit from and SMRs can become competitive in the world energy market if a combination of standardization and simplification of orders, configuration, and production are implemented. This would require wholesale changes in the way SMRs are produced, manufactured and regulated, but nothing that other industries have not implemented and proven successful.

  6. Synergistic extraction of vanadium (V, IV) with dithizone

    Energy Technology Data Exchange (ETDEWEB)

    Akaiwa, H.; Kawamoto, H.; Hiyamuta, E. (Gunma Univ., Kiryu (Japan). Faculty of Technology)


    By employing the synergistic extraction technique, vanadium (V, IV) has been found to form the primary dithizonate in the presence of a synergist. The extraction of the element proceeds according to the following equations. VO/sub 2//sup +/ + H/sub 2/dz,sub(org) + TBPO sub(org) reversible VO/sub 2/(Hdz)(TBPO)sub(org) + H/sup +/, and VOOH/sup +/ + H/sub 2/dz,sub(org) + TOPO sub(org) reversible VOOH(Hdz)(TOPO)sub(org) + H/sup +/, where H/sub 2/dz, TBPO, and TOPO denote dithizone, tributylphosphine oxide and trioctylphosphine oxide, respectively, and the subscript org indicates the benzene phase. The resulting adduct VO/sub 2/(Hdz)(TBPO) has an absorption maximum at 503 nm and is stable for at least 1 h. However, the red color of VOOH(Hdz)(TOPO) in benzene fades away during the standing time, probably due to the dimerization of the initially extracted monomeric species.

  7. II-IV-V Based Thin Film Tandem Photovoltaic Cell

    Energy Technology Data Exchange (ETDEWEB)

    Newman, Nathan [Arizona State Univ., Mesa, AZ (United States); van Schilfgaarde, Mark [Arizona State Univ., Mesa, AZ (United States)


    [Through a combination of theory and experiment that, absent unknown mitigating factors, a tandem cell whose (wide-gap. 1.8 eV) top layer is made of ZnSnP2 and whose (narrow gap, 1.1 eV) bottom layer consisting of ZnGeAs2 are near-ideal materials for a tandem cell. Not only are there gaps optimally adjusted to the solar spectrum, but the two compounds are lattice-matched, and their energy band structure and optical absorption are also near-ideal (they closely resemble that of GaAs). Our first major challenge is to establish that high-quality II-IV-V thin films can be synthesized. We have begun growing and characterizing films of ZnGeAs2 and ZnSnP2, initially grown on Ge substrates (the lattice constant of Ge matches these compounds) by pulsed laser ablation and sputtering. In tandem are theoretical calculations to guide the experiments. The goal is to develop methods that can be used to produce a pair of lattice-matched thin films that will be useful in tandem cells.

  8. Two-dimensional multiferroics in monolayer group IV monochalcogenides (United States)

    Wang, Hua; Qian, Xiaofeng


    Low-dimensional multiferroic materials hold great promises in miniaturized device applications such as nanoscale transducers, actuators, sensors, photovoltaics, and nonvolatile memories. Here, using first-principles theory we predict that two-dimensional (2D) monolayer group IV monochalcogenides including GeS, GeSe, SnS, and SnSe are a class of 2D semiconducting multiferroics with giant strongly-coupled in-plane spontaneous ferroelectric polarization and spontaneous ferroelastic lattice strain that are thermodynamically stable at room temperature and beyond, and can be effectively modulated by elastic strain engineering. Their optical absorption spectra exhibit strong in-plane anisotropy with visible-spectrum excitonic gaps and sizable exciton binding energies, rendering the unique characteristics of low-dimensional semiconductors. More importantly, the predicted low domain wall energy and small migration barrier together with the coupled multiferroic order and anisotropic electronic structures suggest their great potentials for tunable multiferroic functional devices by manipulating external electrical, mechanical, and optical field to control the internal responses, and enable the development of four device concepts including 2D ferroelectric memory, 2D ferroelastic memory, and 2D ferroelastoelectric nonvolatile photonic memory as well as 2D ferroelectric excitonic photovoltaics.

  9. Cloning, expression, and activity of type IV antifreeze protein from cultured subtropical olive flounder (Paralichthys olivaceus

    Directory of Open Access Journals (Sweden)

    Jong Kyu Lee


    Full Text Available Abstract Antifreeze proteins (AFPs lower the freezing point but not the melting point of aqueous solutions by inhibiting the growth of ice crystals via an adsorption-inhibition mechanism. However, the function of type IV AFP (AFP IV is questionable, as its antifreeze activity is on the verge of detectable limits, its physiological concentration in adult fish blood is too low to function as a biological antifreeze, and its homologues are present even in fish from tropic oceans as well as freshwater. Therefore, we speculated that AFP IV may have gained antifreeze activity not by selective pressure but by chance. To test this hypothesis, we cloned, expressed, and assayed AFP IV from cultured subtropical olive flounder (Paralichthys olivaceus, which do not require antifreeze protein for survival. Among the identified expressed sequence tags of the flounder liver sample, a 5′-deleted complementary DNA (cDNA sequence similar to the afp4 gene of the longhorn sculpin was identified, and its full-length cDNA and genome structure were examined. The deduced amino acid sequence of flounder AFP IV shared 55, 53, 52, and 49 % identity with those of Pleuragramma antarcticum, Myoxocephalus octodecemspinosus, Myoxocephalus scorpius, and Notothenia coriiceps, respectively. Furthermore, the genomic structure of this gene was conserved with those of other known AFP IVs. Notably, the recombinant AFP IV showed a weak but distinct thermal hysteresis of 0.07 ± 0.01 °C at the concentration of 0.5 mg/mL, and ice crystals in an AFP IV solution grew star-shaped, which are very similar to those obtained from other polar AFP IVs. Taken together, our results do not support the hypothesis of evolution of AFP IV by selective pressure, suggesting that the antifreeze activity of AFP IV may have been gained by chance.

  10. Expression of 72 kilodalton type IV collagenase (gelatinase A) in benign and malignant ovarian tumors. (United States)

    Autio-Harmainen, H; Karttunen, T; Hurskainen, T; Höyhtyä, M; Kauppila, A; Tryggvason, K


    72 Kilodalton (kd) type IV collagenase is a matrix metalloproteinase that specifically cleaves type IV collagen molecules. The enzyme has been postulated to have an important role in the invasion and spread of malignant tumors. In situ hybridization was used to study the expression of the 72 kd type IV collagenase mRNA in 24 benign, 2 semimalignant, and 15 malignant ovarian tumors and in 5 metastases of ovarian serous adenocarcinomas. The results were correlated with the expression of the mRNA for the alpha 1(IV) chain of type IV collagen and with the corresponding immunohistochemical distribution of the enzyme. The results showed that the more malignant an ovarian tumor was, the more clearly mRNA expressions for both 72 kd type IV collagenase and the alpha 1(IV) chain could be detected in tumor cells. The expression of both types of mRNAs was localized within the cells of tumor stroma and occurred mainly in fibroblasts and vascular endothelial cells. Epithelial tumor cells only rarely expressed these mRNAs. Immunohistochemical stainings localized the 72 kd collagenase as well to the stromal cells as to the epithelial cells of both benign and malignant tumors. The findings indicate that genes for the 72 kd type IV collagenase and for its substrate are simultaneously active in the same cells of the tumor stroma. The difference in the in situ hybridization and immunohistochemical findings could be explained by a possible variation in the metabolic balance between synthesis and accumulation of the protein in different cell types. It can also be proposed that the activity of the 72 kd type IV collagenase would be mediated through a receptor-like mechanism present on epithelial cells which could bind the 72 kd type IV collagenase synthesized elsewhere. There is also a possibility that the gelatinolytic activity of the mesenchymally synthesized 72 kd type IV collagenase would be consumed to degrade extracellular matrix proteins other than basement membranes.

  11. Transformation of Tri-Titanium(IV-Substituted α-Keggin Polyoxometalate (POM into Tetra-Titanium(IV-Substituted POMs : Reaction Products of Titanium(IV Sulfate with the Dimeric Keggin POM Precursor under Acidic Conditions

    Directory of Open Access Journals (Sweden)

    Kenji Nomiya


    Full Text Available Reaction products of titanium(IV sulfate in HCl-acidic aqueous solution with the dimeric species linked through three intermolecular Ti-O-Ti bonds of the two tri-titanium(IV-substituted α-Keggin polyoxometalate (POM subunits are described. Two novel titanium(IV-containing α-Keggin POMs were obtained under different conditions. One product was a dimeric species through two intermolecular Ti-O-Ti bonds of the two tetra-titanium(IV-substituted α-Keggin POM subunits, i.e., [[{Ti(H2O3}2(μ-O](α-PW9Ti2O38]26- (1. The other product was a monomeric α-Keggin species containing the tetra-titanium(IV oxide cluster and two coordinated sulfate ions, i.e., [{Ti4(μ-O3(SO42(H2O8}(α-PW9O34]3- (2. Molecular structures of 1 and 2 were also discussed based on host (lacunary site-guest (titanium atom chemistry.

  12. Evaluation of the PLATO IV Computer-based Education System in the Community College. Final Report. (United States)

    Murphy, Richard T.; Appel, Lola Rhea

    PLATO IV (Programmed Logic for Automatic Teaching Operations) is the fourth generation of a computer assisted instructional system developed at the University of Illinois. The use of PLATO IV at five community colleges, and an evaluation of its educational impact on participating students, instructors, and colleges are described. The PLATO system…

  13. Type IV Neonatal Early-Onset Group B Streptococcal Disease in a United States Hospital▿ (United States)

    Puopolo, Karen M.; Madoff, Lawrence C.


    Group B streptococcus (GBS) serotypes causing neonatal disease vary by geographic region. Surveillance at the Brigham and Women's Hospital in Boston, Massachusetts, revealed a case of neonatal early-onset sepsis caused by type IV GBS. Neonatal type IV disease occurs in the Middle East but has not recently been described in U.S. infants. PMID:17267636

  14. Xylanase XYN IV from Trichoderma reesei showing exo- and endo-xylanase activity (United States)

    A novel xylanase from Trichoderma reesei Rut C30, named XYN IV, was purified from the cellulolytic system of the fungus. The enzyme was discovered on its ability to attack aldotetraohexenuronic acid (HexA-2Xyl-4Xyl-4Xyl, HexA3Xyl3), releasing the reducing-end xylose residue. XYN IV exhibited catalyt...

  15. Portable and wireless IV-curve tracer for >5 kV organic photovoltaic modules

    DEFF Research Database (Denmark)

    Garcia Valverde, Rafael; Chaouki-Almagro, Samir; Corazza, Michael


    The practical design of a wirelessly controlled portable IV-curve tracer based on a capacitive load is described. The design is optimized for the measurement of solar cell modules presenting a high open circuit voltage of up to 6 kV and a low short circuit current below 100 mA. The portable IV-tr...

  16. Vanadium speciation by chromatographic separation of V(IV) and V ...

    African Journals Online (AJOL)

    A new method for vanadium speciation has been developed. The method is based on chromatographic separation of vanadium(IV) and vanadium(V) in acidic medium followed by the determination with ICP-OES. Vanadium species exist in acidic solution (pH < 3) as VO2+ for vanadium(IV) and VO2 + for vanadium(V).

  17. Cross-Mapping APACHE IV "Reasons for Intensive Care Admission" Classification to SNOMED CT

    NARCIS (Netherlands)

    Bakhshi-Raiez, F.; Cornet, R.; de Keizer, N. F.


    The APACHE IV classification is used to capture diagnostic information for calculation of mortality risks in intensive care (IC). The lack of structured and formal definitions for concepts in APACHE IV classification as in any classification results in shortcomings when scaling up for re-use. The

  18. Construct Validity of the WISC-IV with a Referred Sample: Direct versus Indirect Hierarchical Structures (United States)

    Canivez, Gary L.


    The Wechsler Intelligence Scale for Children--Fourth Edition (WISC-IV) is one of the most frequently used intelligence tests in clinical assessments of children with learning difficulties. Construct validity studies of the WISC-IV have generally supported the higher order structure with four correlated first-order factors and one higher-order…

  19. Formation of U(IV) Nanoparticles and Their Growth Mechanism in Mildly Acidic Aqueous Phases

    Energy Technology Data Exchange (ETDEWEB)

    Cha, Wan Sik; Kim, Sun Tae; Cho, Hye Ryun; Jung, Euo Chang [KAERI, Daejeon (Korea, Republic of)


    Previous studies suggest that U(IV) nanoparticle (NP) formation is one of key steps in mineralization or immobilization of uranium which can be mediated either by microbes or by abiotic geochemical reactions. Colloidal NPs in a groundwater system are potential carrier phases influencing RN migration in subsurface environment. However, the mechanism of U(IV) NP formation and the potential reaction intermediates during this solid phase formation process have not been elucidated in detail so far. In this study we attempted to examine the U(IV) nanoparticle formation reactions preceded by the hydrolysis of U{sup 4+} at different pHs, concentrations and temperatures. The kinetics of U(IV) NP formation from dissolved U(IV) species was monitored under mildly acidic conditions (pH 2 ∼ 3) mainly by using UV-Vis absorption spectrophotometry. Dynamic light scattering (DLS) analysis, nanoparticle tracking analysis (NTA) and transmission electron microscopy (TEM) were used to characterize the NPs produced during the reactions. The results demonstrate that the U(IV) NP formation process is very sensitive toward temperature variation. The main outcome of this study is the discovery of the autocatalytic nature of U(IV) NP formation from the supersaturated U(OH){sup 3+} solution in a mildly acidic aqueous solution. The structure of reaction intermediates is proposed to contain oxide linkage. In the presentation the proposed mechanism of the U(IV) NP formation reaction and the properties of primary NPs and their clusters will be discussed in detail.

  20. The Bulimia Test--Revised: Validation with "DSM-IV" Criteria for Bulimia Nervosa. (United States)

    Thelen, Mark H.; And Others


    The Bulimia Test--Revised (BULIT-R) was given to 23 female subjects who met the criteria for bulimia in the "Diagnostic and Statistical Manual of Mental Disorders" (DSM-IV) and 124 female controls. The BULIT-R appears to be a valid instruction for identifying individuals who meet DSM-IV criteria for bulimia. (SLD)

  1. 77 FR 1267 - National Emission Standards for Hazardous Air Pollutant Emissions: Group IV Polymers and Resins... (United States)


    ... Hazardous Air Pollutant Emissions: Group IV Polymers and Resins; Pesticide Active Ingredient Production; and... Emission Standards for Hazardous Air Pollutant Emissions: Group IV Polymers and Resins; Pesticide Active... Polymers and Resins; NESHAP for Pesticide Active Ingredient Production; and NESHAP for Polyether Polyols...

  2. Assessment of High School Students' Understanding of DSM-IV-MR-J Items (United States)

    Pelletier, Amelie; Ladouceur, Robert; Fortin, Josee-Melanie; Ferland, Francine


    The current study examines the understanding of the DSM-IV-MR-J items to assess pathological gambling among adolescents aged 12 to 15, and explores its accuracy. The DSM-IV-MR-J was first administered in the classroom. Participants were assigned to either an experimental or a control group. Participants in the first group were asked to explain the…

  3. Comportamiento de las líneas de Si IV en estrellas calientes (United States)

    Venero, R. O.; Cidale, L. S.; Ringuelet, A. E.

    We study the atmospheric structure of hot stars by means of the analysis of ultraviolet line profiles of Si IV. Our goal is to obtain velocity and temperature laws of the wind as well as ionization structures for atmospheres in NLTE and with radiative equilibrium departures. We present a possible explanation on the appearance of narrow absorption components in Si IV line profiles.

  4. Dipeptidyl peptidase IV is sorted to the secretory granules in pancreatic islet A-cells

    DEFF Research Database (Denmark)

    Poulsen, Mona Dam; Hansen, Gert Helge; Dabelsteen, Erik


    labeling using a monoclonal glucagon antibody as the second primary antibody. These results show that DP IV is sorted to secretory granules in the pig pancreatic islet A-cells. Furthermore, this secretory granule enzyme, as opposed to intestinal brush border DP IV, is suggested to be a soluble protein...

  5. Type IV neonatal early-onset group B streptococcal disease in a United States hospital. (United States)

    Puopolo, Karen M; Madoff, Lawrence C


    Group B streptococcus (GBS) serotypes causing neonatal disease vary by geographic region. Surveillance at the Brigham and Women's Hospital in Boston, Massachusetts, revealed a case of neonatal early-onset sepsis caused by type IV GBS. Neonatal type IV disease occurs in the Middle East but has not recently been described in U.S. infants.

  6. Uranium(IV) adsorption by natural organic matter in anoxic sediments

    Energy Technology Data Exchange (ETDEWEB)

    Bone, Sharon E.; Dynes, James; Cliff, John B.; Barger, John


    Uranium is an important fuel source and a global environmental contaminant. It accumulates in the tetravalent state, U(IV), in anoxic sediments, including ore deposits, marine basins, and contaminated aquifers. However, very little is known about the speciation of U(IV) in low temperature geochemical environments, inhibiting the development of a conceptual model of U behavior. Until recently, U(IV) was assumed to exist predominantly as the sparingly soluble mineral uraninite (UO2) in anoxic sediments; yet studies now show that UO2 is not often dominant in these environments. However, a model of U(IV) speciation under environmentally relevant conditions has not yet been developed. Here we show that complexes of U(IV) adsorb on organic carbon and organic carbon-coated clays in an organic-rich natural substrate under field-relevant conditions. Whereas previous research assumed that the U(IV) product depended on the reduction pathway, our results demonstrate that UO2 formation can be inhibited simply by decreasing the U:solid ratio. Thus, it is the number and type of surface ligands that controls U(IV) speciation subsequent to U(VI) reduction. Projections of U transport and bioavailability, and thus its threat to human and ecosystem health, must consider retention of U(IV) ions within the local sediment environment.

  7. Cerium(IV) carboxymethylcellulose (CMC−Ce ) as an efficient and ...

    Indian Academy of Sciences (India)


    Abstract. Cerium(IV) carboxymethylcellulose (CMC−CeIV) was found to be a highly efficient, eco-friendly and recyclable heterogeneous catalyst for the synthesis of 2,4,6-triarylpyridine derivatives in excellent yields via one-pot multicomponent reaction of various benzaldehydes, acetophenones, and ammonium acetate ...

  8. Reliability of DSM-IV Symptom Ratings of ADHD: Implications for DSM-V (United States)

    Solanto, Mary V.; Alvir, Jose


    Objective: The objective of this study was to examine the intrarater reliability of "DSM-IV" ADHD symptoms. Method: Two-hundred-two children referred for attention problems and 49 comparison children (all 7-12 years) were rated by parents and teachers on the identical "DSM-IV" items presented in two different formats, the…

  9. An Item Response Theory Analysis of DSM-IV Conduct Disorder (United States)

    Gelhorn, Heather; Hartman, Christie; Sakai, Joseph; Mikulich-Gilbertson, Susan; Stallings, Michael; Young, Susan; Rhee, Soo; Corley, Robin; Hewitt, John; Hopfer, Christian; Crowley, Thomas


    Interviews with over 3,000 adolescents were made to evaluate the extent to which DSM-IV criteria characterizes the range of severity of adolescent antisocial behavior within and across sex. The DSM-IV conduct disorder (CD) criteria are a useful indicator of severe adolescent antisocial behavior but some CD criteria display sex bias.

  10. Validation of DSM-IV Model of Psychiatric Syndromes in Children with Autism Spectrum Disorders (United States)

    Lecavalier, Luc; Gadow, Kenneth D.; DeVincent, Carla J.; Edwards, Michael C.


    The objective of this study was to assess the internal construct validity of the DSM-IV as a conceptual model for characterizing behavioral syndromes in children with ASD. Parent and teachers completed the Child Symptom Inventory-4, a DSM-IV-referenced rating scale, for 6-to-12 year old clinic referrals with an ASD (N = 498). Ratings were…

  11. Plutonium(IV) precipitates formed in alkaline media in the presence of various anions

    Energy Technology Data Exchange (ETDEWEB)

    Krot, N.N.; Shilov, V.P.; Yusov, A.B.; Tananaev, I.G.; Grigoriev, M.S.; Garnov, A.Yu.; Perminov, V.P.; Astafurova, L.N.


    The tendency of Pu(IV) to hydrolyze and form true solutions, colloid solutions, or insoluble precipitates has been known since the Manhattan Project. Since then, specific studies have been performed to examine in detail the equilibria of Pu(IV) hydrolytic reactions in various media. Great attention also has been paid to the preparation, structure, and properties of Pu(IV) polymers or colloids. These compounds found an important application in sol-gel technology for the preparation of nuclear fuel materials. A most important result of these works was the conclusion that Pu(IV) hydroxide, after some aging, consists of very small PuO{sub 2} crystallites and should therefore be considered to be Pu(IV) hydrous oxide. However, studies of the properties and behavior of solid Pu(IV) hydroxide in complex heterogeneous systems are rare. The primary goal of this investigation was to obtain data on the composition and properties of Pu(IV) hydrous oxide or other compounds formed in alkaline media under different conditions. Such information is important to understand Pu(IV) behavior and the forms of its existence in the Hanford Site alkaline tank waste sludge. This knowledge then may be applied in assessing plutonium criticality hazards in the storage, retrieval, and treatment of Hanford Site tank wastes as well as in understanding its contribution to the transuranic waste inventory (threshold at 100 nCi/g or about 5 {times} 10{sup {minus}6} M) of the separate solution and solid phases.

  12. 40 CFR 147.1401 - State administered program-Class I, III, IV and V wells. (United States)


    ... CONTROL PROGRAMS Nebraska § 147.1401 State administered program—Class I, III, IV and V wells. The UIC program for Class I, III, IV, and V wells in the State of Nebraska, except those on Indian lands, is the... 40 Protection of Environment 22 2010-07-01 2010-07-01 false State administered program-Class I...

  13. Defining interactions between DNA-PK and ligase IV/XRCC4

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, Hsin-Ling; Yannone, Steven M.; Chen, David J.


    Non-homologous end joining (NHEJ) is a major pathway for the repair of DNA double-strand breaks in mammalian cells. DNA-dependent protein kinase (DNA-PK), ligase IV, and XRCC4 are all critical components of the NHEJ repair pathway. DNA-PK is composed of a heterodimeric DNA-binding component, Ku, and a large catalytic subunit, DNA-PKcs. Ligase IV and XRCC4 associate to form a multimeric complex that is also essential for NHEJ. DNA-PK and ligase IV/XRCC4 interact at DNA termini which results in stimulated ligase activity. Here we define interactions between the components of these two essential complexes, DNA-PK and ligase IV/XRCC4. We find that ligase IV/XRCC4 associates with DNA-PK in a DNA-independent manner. The specific protein-protein interactions that mediate the interaction between these two complexes are further identified. Direct physical interactions between ligase IV and Ku as well as between XRCC4 and DNA-PKcs are shown. No direct interactions are observed between ligase IV and DNA-PKcs or between XRCC4 and Ku. Our data defines the specific protein pairs involved in the association of DNA-PK and ligase IV/XRCC4, and suggests a molecular mechanism for coordinating the assembly of the DNA repair complex at DNA breaks.

  14. Reg IV is a direct target of intestinal transcriptional factor CDX2 in gastric cancer.

    Directory of Open Access Journals (Sweden)

    Yutaka Naito

    Full Text Available REG4, which encodes Reg IV protein, is a member of the calcium-dependent lectin superfamily and potent activator of the epidermal growth factor receptor/Akt/activator protein-1 signaling pathway. Several human cancers overexpress Reg IV, and Reg IV expression is associated with intestinal phenotype differentiation. However, regulation of REG4 transcription remains unclear. In the present study, we investigated whether CDX2 regulates Reg IV expression in gastric cancer (GC cells. Expression of Reg IV and CDX2 was analyzed by Western blot and quantitative reverse transcription-polymerase chain reaction in 9 GC cell lines and 2 colon cancer cell lines. The function of the 5'-flanking region of the REG4 gene was characterized by luciferase assay. In 9 GC cell lines, endogenous Reg IV and CDX2 expression were well correlated. Using an estrogen receptor-regulated form of CDX2, rapid induction of Reg IV expression was observed in HT-29 cells. Reporter gene assays revealed an important role in transcription for consensus CDX2 DNA binding elements in the 5'-flanking region of the REG4 gene. Chromatin immunoprecipitation assays showed that CDX2 binds directly to the 5'-flanking region of REG4. These results indicate that CDX2 protein directly regulates Reg IV expression.

  15. Functionalized nonporous silica nanoparticles as carriers for Pt(iv) anticancer prodrugs. (United States)

    Ravera, M; Gabano, E; Zanellato, I; Perin, E; Arrais, A; Osella, D


    Nonporous silica nanoparticles (SNPs) with an external shell containing primary amino groups were proposed as potential delivery systems for Pt(iv) antitumor prodrugs. Spherical SNPs containing two different external arms, i.e. 3-aminopropyl and N-(6-aminohexyl)aminomethylene, of around 125 nm hydrodynamic diameter were loaded with two different cisplatin-based Pt(iv) complexes, namely (OC-6-44)-diamminedichloridoethoxidosuccinatoplatinum(iv) and (OC-6-44)-diamminedichloridoacetylamidosuccinatoplatinum(iv), through the formation of amide bonds between the pendant amino groups on SNPs and the free carboxylic group of the complexes. In the presence of the N-(6-aminohexyl)aminomethylene arm, the Pt(iv)-SNP conjugates showed a negligible (unwanted) Pt release by hydrolysis, whereas in the presence of ascorbic acid the reduction of Pt(iv) → Pt(ii) caused the substantial release of the active metabolite cisplatin. Conjugate Pt(iv)-SNP exhibited better antiproliferative activity on the Pt-sensitive A2780 human ovarian cancer cell line than the parent cisplatin and their free Pt(iv) precursors, due to their more efficient cellular uptake, likely by endocytosis.

  16. 76 FR 58020 - Prescription Drug User Fee Act IV Information Technology Plan (United States)


    ... HUMAN SERVICES Food and Drug Administration Prescription Drug User Fee Act IV Information Technology... Administration (FDA) is announcing the availability of an updated information technology (IT) plan entitled ``PDUFA IV Information Technology Plan'' (updated plan) to achieve the objectives defined in the...

  17. Plutonium(IV) complexation by diglycolamide ligands - coordination chemistry insight into TODGA-based actinide separations

    NARCIS (Netherlands)

    Reilly, S.D.; Gaunt, A.J.; Scott, B.L.; Modolo, G.; Iqbal, M.; Verboom, Willem; Sarsfield, M.J.


    Complexation of Pu(IV) with TMDGA, TEDGA, and TODGA diglycolamide ligands was followed by vis-NIR spectroscopy. A crystal structure determination reveals that TMDGA forms a 1:3 homoleptic Pu(IV) complex with the nitrate anions forced into the outer coordination sphere

  18. Karel IV. a dvojí Te Deum aneb Jak to bylo tehdy a jak dnes

    Czech Academy of Sciences Publication Activity Database

    Maňour, Ondřej


    Roč. 3, č. 2 (2016) ISSN 2533-6940 Institutional support: RVO:68378076 Keywords : Czech medieval music * Charles IV * society Subject RIV: AL - Art, Architecture, Cultural Heritage

  19. Critical Issues on Materials for Gen-IV Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Caro, M; Marian, J; Martinez, E; Erhart, P


    Within the LDRD on 'Critical Issues on Materials for Gen-IV Reactors' basic thermodynamics of the Fe-Cr alloy and accurate atomistic modeling were used to help develop the capability to predict hardening, swelling and embrittlement using the paradigm of Multiscale Materials Modeling. Approaches at atomistic and mesoscale levels were linked to build-up the first steps in an integrated modeling platform that seeks to relate in a near-term effort dislocation dynamics to polycrystal plasticity. The requirements originated in the reactor systems under consideration today for future sources of nuclear energy. These requirements are beyond the present day performance of nuclear materials and calls for the development of new, high temperature, radiation resistant materials. Fe-Cr alloys with 9-12% Cr content are the base matrix of advanced ferritic/martensitic (FM) steels envisaged as fuel cladding and structural components of Gen-IV reactors. Predictive tools are needed to calculate structural and mechanical properties of these steels. This project represents a contribution in that direction. The synergy between the continuous progress of parallel computing and the spectacular advances in the theoretical framework that describes materials have lead to a significant advance in our comprehension of materials properties and their mechanical behavior. We took this progress to our advantage and within this LDRD were able to provide a detailed physical understanding of iron-chromium alloys microstructural behavior. By combining ab-initio simulations, many-body interatomic potential development, and mesoscale dislocation dynamics we were able to describe their microstructure evolution. For the first time in the case of Fe-Cr alloys, atomistic and mesoscale were merged and the first steps taken towards incorporating ordering and precipitation effects into dislocation dynamics (DD) simulations. Molecular dynamics (MD) studies of the transport of self


    Energy Technology Data Exchange (ETDEWEB)

    Yan, Renbin; Sánchez-Gallego, José R. [Department of Physics and Astronomy, University of Kentucky, 505 Rose St., Lexington, KY 40506-0057 (United States); Tremonti, Christy; Bershady, Matthew A.; Eigenbrot, Arthur; Wake, David A. [Department of Astronomy, University of Winsconsin-Madison, 475 N. Charter Street, Madison, WI 53706-1582 (United States); Law, David R. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Schlegel, David J. [Physics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720-8160 (United States); Bundy, Kevin [Kavli IPMU (WPI), UTIAS, The University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Drory, Niv [McDonald Observatory, Department of Astronomy, University of Texas at Austin, 1 University Station, Austin, TX 78712-0259 (United States); MacDonald, Nicholas [Department of Astronomy, Box 351580, University of Washington, Seattle, WA 98195 (United States); Bizyaev, Dmitry [Apache Point Observatory, P.O. Box 59, sunspot, NM 88349 (United States); Blanc, Guillermo A. [Departamento de Astronomía, Universidad de Chile, Camino el Observatorio 1515, Las Condes, Santiago (Chile); Blanton, Michael R.; Hogg, David W. [Center for Cosmology and Particle Physics, Department of Physics, New York University, 4 Washington Place, New York, NY 10003 (United States); Cherinka, Brian [Dunlap Institute for Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto, Ontario M5S 3H4 (Canada); Gunn, James E. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Harding, Paul [Department of Astronomy, Case Western Reserve University, Cleveland, OH 44106 (United States); Sánchez, Sebastian F., E-mail: [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, A.P. 70-264, 04510 Mexico D.F. (Mexico); and others


    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA), one of three core programs in the Sloan Digital Sky Survey-IV, is an integral-field spectroscopic survey of roughly 10,000 nearby galaxies. It employs dithered observations using 17 hexagonal bundles of 2″ fibers to obtain resolved spectroscopy over a wide wavelength range of 3600–10300 Å. To map the internal variations within each galaxy, we need to perform accurate spectral surface photometry, which is to calibrate the specific intensity at every spatial location sampled by each individual aperture element of the integral field unit. The calibration must correct only for the flux loss due to atmospheric throughput and the instrument response, but not for losses due to the finite geometry of the fiber aperture. This requires the use of standard star measurements to strictly separate these two flux loss factors (throughput versus geometry), a difficult challenge with standard single-fiber spectroscopy techniques due to various practical limitations. Therefore, we developed a technique for spectral surface photometry using multiple small fiber-bundles targeting standard stars simultaneously with galaxy observations. We discuss the principles of our approach and how they compare to previous efforts, and we demonstrate the precision and accuracy achieved. MaNGA's relative calibration between the wavelengths of Hα and Hβ has an rms of 1.7%, while that between [N ii] λ6583 and [O ii] λ3727 has an rms of 4.7%. Using extinction-corrected star formation rates and gas-phase metallicities as an illustration, this level of precision guarantees that flux calibration errors will be sub-dominant when estimating these quantities. The absolute calibration is better than 5% for more than 89% of MaNGA's wavelength range.

  1. Evolution of conjugation and type IV secretion systems. (United States)

    Guglielmini, Julien; de la Cruz, Fernando; Rocha, Eduardo P C


    Genetic exchange by conjugation is responsible for the spread of resistance, virulence, and social traits among prokaryotes. Recent works unraveled the functioning of the underlying type IV secretion systems (T4SS) and its distribution and recruitment for other biological processes (exaptation), notably pathogenesis. We analyzed the phylogeny of key conjugation proteins to infer the evolutionary history of conjugation and T4SS. We show that single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) conjugation, while both based on a key AAA(+) ATPase, diverged before the last common ancestor of bacteria. The two key ATPases of ssDNA conjugation are monophyletic, having diverged at an early stage from dsDNA translocases. Our data suggest that ssDNA conjugation arose first in diderm bacteria, possibly Proteobacteria, and then spread to other bacterial phyla, including bacterial monoderms and Archaea. Identifiable T4SS fall within the eight monophyletic groups, determined by both taxonomy and structure of the cell envelope. Transfer to monoderms might have occurred only once, but followed diverse adaptive paths. Remarkably, some Firmicutes developed a new conjugation system based on an atypical relaxase and an ATPase derived from a dsDNA translocase. The observed evolutionary rates and patterns of presence/absence of specific T4SS proteins show that conjugation systems are often and independently exapted for other functions. This work brings a natural basis for the classification of all kinds of conjugative systems, thus tackling a problem that is growing as fast as genomic databases. Our analysis provides the first global picture of the evolution of conjugation and shows how a self-transferrable complex multiprotein system has adapted to different taxa and often been recruited by the host. As conjugation systems became specific to certain clades and cell envelopes, they may have biased the rate and direction of gene transfer by conjugation within prokaryotes.

  2. Structural Characterization of Novel Pseudomonas aeruginosa Type IV Pilins

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Y.; Jackson, S; Aidoo, F; Junop, M; Burrows, L


    Pseudomonas aeruginosa type IV pili, composed of PilA subunits, are used for attachment and twitching motility on surfaces. P. aeruginosa strains express one of five phylogenetically distinct PilA proteins, four of which are associated with accessory proteins that are involved either in pilin posttranslational modification or in modulation of pilus retraction dynamics. Full understanding of pilin diversity is crucial for the development of a broadly protective pilus-based vaccine. Here, we report the 1.6-{angstrom} X-ray crystal structure of an N-terminally truncated form of the novel PilA from strain Pa110594 (group V), which represents the first non-group II pilin structure solved. Although it maintains the typical T4a pilin fold, with a long N-terminal {alpha}-helix and four-stranded antiparallel {beta}-sheet connected to the C-terminus by a disulfide-bonded loop, the presence of an extra helix in the {alpha}{beta}-loop and a disulfide-bonded loop with helical character gives the structure T4b pilin characteristics. Despite the presence of T4b features, the structure of PilA from strain Pa110594 is most similar to the Neisseria gonorrhoeae pilin and is also predicted to assemble into a fiber similar to the GC pilus, based on our comparative pilus modeling. Interactions between surface-exposed areas of the pilin are suggested to contribute to pilus fiber stability. The non-synonymous sequence changes between group III and V pilins are clustered in the same surface-exposed areas, possibly having an effect on accessory protein interactions. However, based on our high-confidence model of group III PilA{sub PA14}, compensatory changes allow for maintenance of a similar shape.

  3. Can children undergoing ophthalmologic examinations under anesthesia be safely anesthetized without using an IV line?

    Directory of Open Access Journals (Sweden)

    Vigoda M


    Full Text Available Michael M Vigoda, Azeema Latiff, Timothy G Murray, Jacqueline L Tutiven, Audina M Berrocal, Steven GayerBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USAPurpose: To document that with proper patient and procedure selection, children undergoing general inhalational anesthesia for ophthalmologic exams (with or without photos, ultrasound, laser treatment, peri-ocular injection of chemotherapy, suture removal, and/or replacement of ocular prosthesis can be safely anesthetized without the use of an intravenous (IV line. Children are rarely anesthetized without IV access placement. We performed a retrospective study to determine our incidence of IV access placement during examinations under anesthesia (EUA and the incidence of adverse events that required intraoperative IV access placement.Methods: Data collected from our operating room (OR information system includes but is not limited to diagnosis, anesthesiologist, surgeon, and location of IV catheter (if applicable, patient’s date of birth, actual procedure, and anesthesia/procedure times. We reviewed the OR and anesthetic records of children (>1 month and <10 years who underwent EUAs between January 1, 2003 and May 31, 2009. We determined the percentage of children who were anesthetized without IV access placement, as well as the incidence of any adverse events that required IV access placement, intraoperatively.Results: We analyzed data from 3196 procedures performed during a 77-month period. Patients’ ages ranged from 1 month to 9 years. Overall, 92% of procedures were performed without IV access placement. Procedure duration ranged from 1–39 minutes. Reasons for IV access placement included parental preference for antinausea medication and/or attending preference for IV access placement. No child who underwent anesthesia without an IV line had an intraoperative adverse event requiring insertion of an IV line.Conclusion: Our data suggest that for

  4. Generation IV{sup +f}usion fission hybrid engineering

    Energy Technology Data Exchange (ETDEWEB)

    Suh, Kune Y. [Seoul National Univ., Seoul (Korea, Republic of)


    World energy outlook requires environmental friendliness, sustatinability and improved economic feasibility. The Exploratory Energy Utilization Systemics (XEUS) is being developed at the Seoul National University (SNU) to satisfy these demands. Generation IV (Gen IV) and fusion reactors are considered as candidates for the primary system. Battery omnibus Reactor Integral System (BORIS) is a liquid metal cooled fast reactor which is one of the Gen IV concepts. Fusion Engineering Lifetime Integral Explored (FELIX) is a fusion demonstration reactor for power generation. These two concepts are considered as dominant options for future nuclear energy source from the environmental, commercial and nonproliferation points of view. XEUS may as well be applied to the fusion fission hybrid system. The system code is being developed to analyze the steady state and transient behavior of the primary system. Compact and high efficiency heat exchangers are designed in the Loop Energy Exchanger Integral System (LEXIS). Modular Optimized Brayton Integral System (MOBIS) incorporates a Brayton cycle with supercritical fluid to achieve high power conversion ratio. The high volumetric energy density of the Brayton cycle enables designers to reduce the size and eventually the cost of the system when compared with that of the Ranking cycle. MOBIS is home to heat exchangers and turbo machineries. The advanced shell and tube or printed circuit heat exchanger is considered as heat transfer components to reduce size of the system. the supercritical fluid driven turbines and compressor are designed to achieve higher component efficiency. The fusion breeder FELIX is a fusion reactor designed with special blankets to maximize the transmutation by 14MeV neutrons of {sup 9}2{sup U2}38{sup t}o {sup 9}4{sup P}u{sup 2}39{sup o}r {sup 9}0{sup T}h{sup 2}32{sup t}o {sup 9}2{sup U2}33{sup f}or use as a fuel for fission reactors. Breeding fissile fuels has not been a goal of the Korean fusion energy

  5. Monitoring and Fault Detection in Photovoltaic Systems Based On Inverter Measured String I-V Curves

    DEFF Research Database (Denmark)

    Spataru, Sergiu; Sera, Dezso; Kerekes, Tamas


    Most photovoltaic (PV) string inverters have the hardware capability to measure at least part of the current-voltage (I-V) characteristic curve of the PV strings connected at the input. However, this intrinsic capability of the inverters is not used, since I-V curve measurement and monitoring......-of-system components through increased series resistance losses, or shunting of the PV modules. To achieve this, we propose and experimentally demonstrate three complementary PV system monitoring methods that make use of the I-V curve measurement capability of a commercial string inverter. The first method is suitable...... for monitoring single or independent PV strings, and is based on evaluating the ratio of certain operation points on the string I-V curve. The second method is applicable to PV systems with identical strings, and is based on monitoring and inter-comparison of string I-V curve parameters. For PV systems with non...

  6. DSM-V from the perspective of the DSM-IV experience. (United States)

    Walsh, B Timothy


    This article provides a brief overview of the development of the diagnostic criteria for eating disorders in DSM-IV. The process by which DSM-IV was developed is reviewed, including perspectives on what constitutes diagnostic validity and clinical utility, and their importance in assessing proposed changes in diagnostic criteria. The question of whether alterations in diagnostic criteria would clearly improve clinical utility was a major consideration in the DSM-IV process. Because of concerns that changes in diagnostic criteria would be disruptive and might entail loss of established knowledge, the DSM-IV Task Force assumed a generally conservative stance vis-à-vis change. The process of developing DSM-V is just beginning, and it is far from clear what alterations in diagnostic criteria for eating disorders will occur. However, the evolution of DSM-IV may provide a useful perspective on the development of DSM-V. (c) 2007 by Wiley Periodicals, Inc.

  7. Analysis of Cadmium in Undissolved Anode Materials of Mark-IV Electrorefiner

    Energy Technology Data Exchange (ETDEWEB)

    Tae-Sic Yoo; Guy L. Fredrickson; DeeEarl Vaden; Brian R. Westphal


    The Mark-IV electrorefiner (Mk-IV ER) contains an electrolyte/molten cadmium system for refining uranium electrochemically. Typically, the anode of the Mk-IV ER consists of the chopped sodium-bonded metallic driver fuels, which have been primarily U-10Zr binary fuels. Chemical analysis of the residual anode materials after electrorefining indicates that a small amount of cadmium is removed from the Mk-IV ER along with the undissolved anode materials. Investigation of chemical analysis data indicates that the amount of cadmium in the undissolved anode materials is strongly correlated with the anode rotation speeds and the residence time of the anode in the Mk-IV ER. Discussions are given to explain the prescribed correlation.

  8. RNA polymerases IV and V influence the 3' boundaries of Polymerase II transcription units in Arabidopsis. (United States)

    McKinlay, Anastasia; Podicheti, Ram; Wendte, Jered M; Cocklin, Ross; Rusch, Douglas B


    Nuclear multisubunit RNA polymerases IV and V (Pol IV and Pol V) evolved in plants as specialized forms of Pol II. Their functions are best understood in the context of RNA-directed DNA methylation (RdDM), a process in which Pol IV-dependent 24 nt siRNAs direct the de novo cytosine methylation of regions transcribed by Pol V. Pol V has additional functions, independent of Pol IV and 24 nt siRNA biogenesis, in maintaining the repression of transposons and genomic repeats whose silencing depends on maintenance cytosine methylation. Here we report that Pol IV and Pol V play unexpected roles in defining the 3' boundaries of Pol II transcription units. Nuclear run-on assays reveal that in the absence of Pol IV or Pol V, Pol II occupancy downstream of poly A sites increases for approximately 12% of protein-coding genes. This effect is most pronounced for convergently transcribed gene pairs. Although Pols IV and V are detected near transcript ends of the affected Pol II - transcribed genes, their role in limiting Pol II read-through is independent of siRNA biogenesis or cytosine methylation for the majority of these genes. Interestingly, we observed that splicing was less efficient in pol IV or pol V mutant plants, compared to wild-type plants, suggesting that Pol IV or Pol V might affect pre-mRNA processing. We speculate that Pols IV and V (and/or their associated factors) play roles in Pol II transcription termination and pre-mRNA splicing by influencing polymerase elongation rates and/or release at collision sites for convergent genes.

  9. DSM-IV diagnosis in depressed primary care patients with previous psychiatric ICD-10 bipolar disorder. (United States)

    Angst, Jules; Hantouche, Elie; Caci, Hervé; Gaillard, Raphael; Lancrenon, Sylvie; Azorin, Jean-Michel


    In the past 20 years, much evidence has accumulated against the overly restrictive diagnostic concepts of hypomania in DSM-IV and DSM-IV-TR. We tested DSM-IV-TR and a broader modified version (DSM-IV-TRm) for their ability to detect bipolarity in patients who had been treated for bipolar disorders (BD) in psychiatric settings, and who now consulted general practitioners (GPs) for new major depressive episodes (MDE). Bipolact II was an observational, single-visit survey involving 390 adult patients attending primary care for MDE (DSM-IV-TR criteria) in 201 GP offices in France. The participating GPs (53.3 ± 6.5 years old, 80.1% male) were trained by the Bipolact Educational Program, and were familiar with the medical care of depressive patients. Of the 390 patients with MDE, 129 (33.1%) were previously known as bipolar patients (ICD-10 criteria). Most of the latter bipolar patients (89.7%) had previously been treated with antidepressants. Only 9.3% of them met DMS-IV-TR criteria for BD. Conversely, 79.1% of the 129 bipolar patients met DMS-IV-TRm criteria for BD and showed strong associations with impulse control disorders and manic/hypomanic switches during antidepressant treatment. Limited training of participating GPs, recall bias of patients, and the study not being representative for untreated bipolar patients. Very few ICD-10 bipolar patients consulting French GPs for MDE met DSM-IV-TR criteria for bipolar diagnosis, which suggests that DSM-IV-TR criteria are insufficient and too restrictive for the diagnosis of BD. DSM-IV-TRm was more sensitive, but 20% of bipolar patients were undetected. © 2013 Elsevier B.V. All rights reserved.

  10. Astragaloside IV protects rat gastric mucosa against aspirin-induced damage. (United States)

    Fan, Dan-Dan; Lin, Shan; Song, Yan-Ping; Wang, Ze-Yu; Liu, Bo; Gao, Sai-Nan; Fan, Yu-Hua; Zhu, Shan; Li, Sen; Jiang, Lei


    Aspirin (Asp) is commonly used as an anti-inflammatory drug, but the long-term usage of Asp can lead to severe gastrointestinal damage. Thus the co-administering of Asp with another drug that can suppress its side effect while having no impact on its anti-inflammatory activity would be ideal. Astragaloside IV (AST-IV) is a natural anti-inflammatory compound that has been shown to protect rat gastric mucosa from anhydrous ethanol-inflicted damage. In this study, we investigated whether AST-IV could protect rat gastric mucosa against Asp-induced gastric mucosal damage. Wistar rats administered 150mg/kg Asp showed significant damage to the gastric mucosa, as revealed by gastric damage score and histological evaluation. However, this was largely abolished by co-administering Asp and 25mg/kg or 50mg/kg AST-IV. The protective mechanism of AST-IV involved the suppression of Asp-induced inhibition of cycloxygenase-1 (COX-1) expression, prostaglandin E2 (PGE2) production, superoxide dismutase (SOD) activity and nitric oxide (NO) production. AST-IV blocked Asp-induced inhibition of SOD activity through preventing Asp from inhibiting the expression of SOD-1, both at the mRNA and protein levels. AST-IV did not appear to interfere with the anti-inflammatory activity of Asp since COX-2 level in model gastritis rats treated with Asp plus AST-IV was equally suppressed as in model gastritis rats treated with Asp alone. The results clearly showed that AST-IV could neutralize the toxicity of Asp while having no impact on its anti-inflammatory activity. AST-IV could therefore be considered as a potential drug for relieving the side effect associated with the long-term usage of Asp. Copyright © 2016 Elsevier B.V. All rights reserved.


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    Nidialkova N. А.


    Full Text Available The purpose of the research was to investigate the influence of stanum (IV and germanium (IV coordination compounds on peptidases 1 and 2 of Bacillus thuringiensis var. israelensis ІМV В-7465 activity. The study of coordination compounds effect on peptidase activity was carried out by complexes with the enzymes incubation and residual activity to the collagen, elastin and fibrin determination. It was revealed the regularity in the influence of different structure complex compounds on peptidases of B. thuringiensis var. israelensis ІМV В-7465 activity. The stanum (IV complexes with salicyloylhydrazones of aromatic aldehydes increase collagenase and elastase activities. Substituents replacement in aldehyde fragment of stanum (IV with isonicotinoylhydrazones of aromatic aldehydes complexes by the less polar ones contributed to increase of elastase activity of both enzymes while an absence of substituents enables to increase peptidase 2 fibrinolytic activity. The complexes of germanіum (IV with isonicotinoylhydrazone of salicylic aldehyde which contain Zn and Co, increased collagenase activity of the peptidase 1 as well as elastase and fibrinolytic activities of the peptidase 2. In general, all tested complexes may be considered as peptidase effectors of B. thuringiensis var. israelensis ІМV В-7465. A difference of complexes effect on activities of the both enzymes is due to the characteristics of the structure of coordination compounds.

  12. Revised values of the bond-valence parameters for Te(IV)-O, Te(VI)-O and Te(IV)-Cl. (United States)

    Mills, Stuart J; Christy, Andrew G


    Bond-valence parameters r0 and b have been re-determined for Te(IV)-O: r0 = 1.9605 Å, b = 0.41; Te(VI)-O: r0 = 1.921 Å, b = 0.56; and Te(IV)-Cl: r0 = 2.3115 Å, b = 0.555. Bond distance data from 208 independent Te(IV)-O polyhedra, 118 Te(VI)-O polyhedra and 26 Te(IV)-Cl polyhedra were used, and all neighbours out to 3.5 Å were included. Root-mean square deviations of bond-valence sums on Te from ideal values were 0.1934, 0.1939 and 0.0865 v.u. The good fit for Te(IV)-O over a range of Te coordination numbers from 3 to 12 demonstrates that there is no essential difference in character between short `primary' Te-O bonds, oriented away from the Te lone pair, and longer `secondary' Te-O bonds on the same side of the Te atom as the lone pair. Comparison of bond-valence sums for Te-O polyhedra obtained using the new parameters with those calculated using earlier literature values shows that the new parameters give a narrower spread of calculated bond-valence sums, which means much closer to the formal valence for both oxidation states of tellurium.

  13. Role of i.v. urography in patients with haematuria. (United States)

    Mishra, Vibhash C; Rowe, Edward; Rao, Amrith R; Laniado, Marc E; Motiwala, Hanif G; Hudd, Charles; Karim, Omer M A


    Traditionally, patients presenting with haematuria undergo a series of investigations, including urine cytology, cystoscopy, i.v. urography (IVU) and renal tract ultrasound (US). Studies have suggested that the omission of IVU as a routine investigation for painless haematuria does not dramatically reduce the detection rate of malignant conditions. In this large retrospective study we evaluated the impact of the omission of IVU on the diagnosis of renal tract malignancies and other non-malignant but significant conditions. A retrospective analysis of all patients attending our haematuria clinic between January 2000 and August 2002 was carried out. The diagnostic yields of IVU and a US scan were compared and the significance of abnormalities missed by either modality was assessed with regard to the overall management of patients. Diagnoses were divided into those that were significant and potentially harmful [e.g. tumour, pelvi-ureteric junction (PUJ) obstruction, hydronephrosis] and those that were insignificant and harmless (e.g. simple cyst, non-obstructing calculus). Liddell's exact test for matched pairs was used to test for statistical significance and to give the relative risk of a positive result. A total of 1211 patients were included in the study. When cytology, cystoscopy and US were normal, IVU did not detect any additional malignant pathology. Performing IVU instead of a US scan would have resulted in 74 non-malignant conditions remaining undiagnosed. Similarly, US alone would have missed 64 non-malignant lesions. Six non-malignant but significant conditions, including PUJ obstruction (n = 5) and benign ureteric stricture with hydronephrosis (n = 1), were missed by US but detected by IVU. In this cohort of retrospectively studied patients attending a haematuria clinic, IVU could safely have been omitted without decreasing the overall detection of malignant pathologies. Nevertheless, significant non-malignant pathologies would have remained undiagnosed

  14. Structural Basis of DNA Ligase IV-Artemis Interaction in Nonhomologous End-Joining

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    Pablo De Ioannes


    Full Text Available DNA ligase IV (LigIV and Artemis are central components of the nonhomologous end-joining (NHEJ machinery that is required for V(DJ recombination and the maintenance of genomic integrity in mammalian cells. We report here crystal structures of the LigIV DNA binding domain (DBD in both its apo form and in complex with a peptide derived from the Artemis C-terminal region. We show that LigIV interacts with Artemis through an extended hydrophobic surface. In particular, we find that the helix α2 in LigIV-DBD is longer than in other mammalian ligases and presents residues that specifically interact with the Artemis peptide, which adopts a partially helical conformation on binding. Mutations of key residues on the LigIV-DBD hydrophobic surface abolish the interaction. Together, our results provide structural insights into the specificity of the LigIV-Artemis interaction and how the enzymatic activities of the two proteins may be coordinated during NHEJ.

  15. Characterization of AWAP IV, the C-terminal domain of the avian protein AWAK. (United States)

    Townes, C L; Milona, P; Hall, J


    AWAP IV constitutes the C-terminal domain of the larger 81 kDa protein AWAK [Avian WAP (whey acidic protein) domain- and Kunitz domain-containing], which is predicted, through conserved domain database searching, to contain at least four WAP domains and one Kunitz domain. RT (reverse transcription)-PCR analyses revealed mRNA transcripts encoding AWAP IV in the small intestinal and kidney tissues of 5-day-old Salmonella-infected chicks. Time-kill antimicrobial assays using rAWAP IV (recombinant AWAP IV) cell lysate indicated antimicrobial activity against gram-positive and gram-negative bacteria including Salmonella, Streptococcus and Staphylococcus spp. In addition, permeabilization of the outer membrane of Salmonella, as shown by the NPN (N-phenyl-1-naphthylamine) fluorescent probe assay, supported the ability of rAWAP IV to disrupt prokaryotic membranes. WAP domains can function as inhibitors of serine protease activity, and the microbial serine proteases subtilisin and proteinase K were inhibited by rAWAP IV cell lysate. However, at comparable concentrations, no significant inhibition of the mammalian serine protease elastase was observed. The combined broad-spectrum antibacterial and anti-protease activities of AWAP IV suggest a novel role in the avian innate defence mechanisms operating against microbial infection.

  16. Clinical characteristics of patients with Rutherford category IV, compared with V and VI

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    Taketsugu Tsuchiya


    Full Text Available Objective: Patients categorized Rutherford category IV might have different characteristics compared with Rutherford category V and VI. Our study aims were to estimate the clinical differences between Rutherford category IV and Rutherford category V and VI, for those underwent endovascular therapy for isolated infrapopliteal disease, and also to find risk factors for endovascular therapy in Rutherford category IV. Methods: Based on the Japanese multi-center registry data, 1091 patients with 1332 limbs (Rutherford category IV: 226 patients with 315 limbs, Rutherford category V and VI: 865 patients with 1017 limbs were analyzed retrospectively. Results: Patients’ backgrounds and lesions’ characteristics had significant differences. Both freedom rate from major adverse limb event with perioperative death and amputation-free survival rate at 1 year were better in Rutherford category IV than Rutherford category V and VI (93.6% vs 78.3%, 87.7% vs 66.7% and those maintained to 3 years (p  3.0 mg/dL, chronic obstructive pulmonary disease, and coronary artery disease in Rutherford category IV. Conclusion: From the present results, Rutherford category IV should be recognized to have quite different backgrounds and better outcome from Rutherford category V and VI.

  17. Truncation of class IV chitinases from Arabidopsis by secreted fungal proteases. (United States)

    Naumann, Todd A; Price, Neil P J


    Plant class IV chitinases have a small amino-terminal chitin-binding domain and a larger chitinase domain, and are involved in plant defence against fungal infection. Our previous work on the chitinases ChitA and ChitB from the model monocotyledon Zea mays showed that the chitin-binding domain is removed by secreted fungal proteases called fungalysins. In this article, we extend this work to dicotyledons. The effects of fungalysin-like proteases on four class IV chitinases from the model dicotyledon Arabidopsis thaliana were analysed. Four Arabidopsis chitinases were heterologously expressed in Pichia pastoris, purified and shown to have chitinase activity against a chitohexaose (dp6) substrate. The incubation of these four chitinases with Fv-cmp, a fungalysin protease secreted by Fusarium verticillioides, resulted in the truncation of AtchitIV3 and AtchitIV5. Moreover, incubation with secreted proteins from Alternaria brassicae, a pathogen of A. thaliana and brassica crops, also led to a similar truncation of AtchitIV3 and AtchitIV4. Our finding that class IV chitinases from both dicotyledons (A. thaliana) and monocotyledons (Z. mays) are truncated by proteases secreted by specialized pathogens of each plant suggests that this may be a general mechanism of plant-fungal pathogenicity. © 2012 THE AUTHORS. MOLECULAR PLANT PATHOLOGY © 2012 BSPP AND BLACKWELL PUBLISHING LTD.

  18. Infection control in IV therapy: a review of the chain of infection. (United States)

    Lavery, Irene

    The aim of this article is to review the principles of infection control relating to intravenous (IV) therapy. IV therapy and peripheral IV cannulation are common procedures. Zingg and Pittet (2009) noted that as many as 80% of hospitalized patients will have a cannula in situ, and Hart (2008) suggested that patients who require IV therapy are often seriously ill and immunocompromised, thus are more susceptible to infection. The Department of Health (DH) (2007a) estimated that 6000 patients acquire a catheter-related bloodstream infection every year in the UK. Robust standards of practice are therefore paramount to ensure safe and competent practice, both in peripheral IV cannulation and IV care. Using the chain of infection as a framework to review practice will enable practitioners to ensure thorough standards of practice, and the Royal College of Nursing (RCN) (2005) stated that only trained and competent staff using strict aseptic techniques should be involved in IV or cannulae care. Furthermore, the Code (Nursing and Midwifery Council (NMC), (2008) stipulates all practitioners must deliver care based on the best available evidence and/or best practice, and that knowledge and skills for safe and effective practice must be kept up-to-date throughout each health professional's working life.

  19. Solvent extraction separation of zirconium(IV from succinate media with N-n-octylaniline

    Directory of Open Access Journals (Sweden)



    Full Text Available The extraction behavior of zirconium(IV from succinate (0.01 – 0.03 M medium (25 mL with 10 mL 3 % N-n-octylaniline in xylene was investigated. The pH range 3.7 – 5.0 was effective for the quantitative extraction of zirconium(IV. Zirconium(IV was back extracted with 0.5 M HNO3 (3 × 5 mL. The method was free from interferences of a large number of cations and anions. Zirconium(IV was separated from associated elements in its binary mixture with Mo(VI, Nb(V, Re(VII, La(III, Ti(IV, Th(IV and Al(III. The proposed method was applied to synthetic mixtures. The results of analysis indicate that trace amounts of zirconium(IV could be separated effectively from higher amounts of other elements. The method is simple, selective, rapid and eco-friendly.

  20. Astragaloside IV enhances cardioprotection of remote ischemic conditioning after acute myocardial infarction in rats. (United States)

    Cheng, Songyi; Yu, Peng; Yang, Li; Shi, Haibo; He, Anxia; Chen, Hanyu; Han, Jie; Xie, Liang; Chen, Jiandong; Chen, Xiaohu


    Remote ischemic conditioning (RIC) has been shown to be a practical method for protecting the heart from ischemic/reperfusion (I/R) injury. In the present study, we investigated whether or not the combination of RIC and Astragaloside IV (AS-IV) could improve cardioprotection against acute myocardial infarction (AMI)-induced heart failure (HF) when compared with individual treatments. A rat model of AMI was established via permanent ligation of the left anterior descending coronary artery (LAD). Postoperatively, the rats were randomly grouped into a sham group (n=10), a model group (n=15), an AS-IV alone group (n=15), an RIC alone group (n=15) and a combined treatment group (AS-IV+RIC; n=15). All treatments were administered for 2 weeks. After treatment for 2 weeks, the survival rate was improved, the cardiac function was preserved and the infarcted size was limited in AS-IV alone and RIC alone treatment groups compared to the model group, whereas the combined treatment yielded the most optimal protective effects. Additional studies suggested that AS-IV enhanced the cardioprotective effects of RIC by alleviating myocardial fibrosis, suppressing inflammation, attenuating apoptosis and ameliorating impairment of the myocardial ultrastructural. AS-IV enhances the cardioprotective effects of RIC against AMI-induced HF and ventricular remodeling, which represents a potential therapeutic approach for preserving cardiac function and improving the prognosis of AMI.

  1. Characteristics of SCCmec IV and V Methicillin-Resistant Staphylococcus aureus (MRSA) in Israel. (United States)

    Shitrit, Pnina; Openhaim, Michal; Reisfeld, Sharon; Paitan, Yossi; Regev-Yochay, Gili; Carmeli, Yehuda; Chowers, Michal


    Isolation of methicillin-resistant Staphylococcus aureus (MRSA) in healthy individuals is not common in Israel. In our hospital, about 30% of MRSA isolates were SCCmec types IV and V. To identify the demographic and clinical characteristics of patients carrying MRSA SCCmec type IV or V, and to compare them with each other and with those of patients with SCCmec types I-III. We conducted a case-control study that included 501 patients from whom MRSA was isolated: 254 with SCCmec type I, II, or III, and 243 isolates from SCCmec types IV or V. MRSA was isolated from surveillance cultures in 75% of patients and from a clinical site in 25%. The majority of our study population was elderly, from nursing homes, and with extensive exposure to health care. First, we compared characteristics of patients identified through screening. Statistically significant predictors of SCCmec V vs. IV were Arab ethnicity (OR 7.44, 95% CI 1.5-37.9) and hospitalization in the year prior to study inclusion (OR 5.7, 95% CI 1.9-16.9). No differences were found between patients with SCCmec types I-III and patients with SCCmec type IV or V. Analysis of the subset of patients who had clinical cultures yielded similar results. SCCmec types IV and V were common in the hospital setting although rare in the community. It seems that in Israel, SCCmec IV and V are predominantly health care-associated MRSA.

  2. Inconspicuous portable audio/visual recording: transforming an IV pole into a mobile video capture stand. (United States)

    Pettineo, Christopher M; Vozenilek, John A; Kharasch, Morris; Wang, Ernest; Aitchison, Pam; Arreguin, Andrew


    Although a traditional simulation laboratory may have excellent installed audio/visual capabilities, often large classes overwhelm the limited space in the laboratory. With minimal monetary investment, it is possible to create a portable audio/visual stand from an old IV pole. An IV pole was transformed into an audio/visual stand to overcome the burden of transporting individual electronic components during a patient safety research project conducted in an empty patient room with a standardized patient. The materials and methods for making the modified IV pole are outlined in this article. The limiting factor of production is access to an old IV pole; otherwise a few purchases from an electronics store complete the audio/visual IV pole. The modified IV pole is a cost-effective and portable solution to limited space or the need for audio/visual capabilities outside of a simulation laboratory. The familiarity of an IV pole in a clinical setting reduces the visual disturbance of relocated audio/visual equipment in a room previously void of such instrumentation.

  3. Pol IV-Dependent siRNA Production is Reduced in Brassica rapa (United States)

    Huang, Yi; Kendall, Timmy; Mosher, Rebecca A.


    Plants produce a diverse array of small RNA molecules capable of gene regulation, including Pol IV-dependent short interfering (p4-si)RNAs that trigger transcriptional gene silencing. Small RNA transcriptomes are available for many plant species, but mutations affecting the synthesis of Pol IV-dependent siRNAs are characterized only in Arabidopsis and maize, leading to assumptions regarding nature of p4-siRNAs in all other species. We have identified a mutation in the largest subunit of Pol IV, NRPD1, that impacts Pol IV activity in Brassica rapa, an agriculturally important relative of the reference plant Arabidopsis. Using this mutation we characterized the Pol IV-dependent and Pol IV-independent small RNA populations in B. rapa. In addition, our analysis demonstrates reduced production of p4-siRNAs in B. rapa relative to Arabidopsis. B. rapa genomic regions are less likely to generate p4-siRNAs than Arabidopsis but more likely to generate Pol IV-independent siRNAs, including 24 nt RNAs mapping to transposable elements. These observations underscore the diversity of small RNAs produced by plants and highlight the importance of genetic studies during small RNA analysis. PMID:24833221

  4. Pol IV-Dependent siRNA Production is Reduced in Brassica rapa

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    Rebecca A. Mosher


    Full Text Available Plants produce a diverse array of small RNA molecules capable of gene regulation, including Pol IV-dependent short interfering (p4-siRNAs that trigger transcriptional gene silencing. Small RNA transcriptomes are available for many plant species, but mutations affecting the synthesis of Pol IV-dependent siRNAs are characterized only in Arabidopsis and maize, leading to assumptions regarding nature of p4-siRNAs in all other species. We have identified a mutation in the largest subunit of Pol IV, NRPD1, that impacts Pol IV activity in Brassica rapa, an agriculturally important relative of the reference plant Arabidopsis. Using this mutation we characterized the Pol IV-dependent and Pol IV-independent small RNA populations in B. rapa. In addition, our analysis demonstrates reduced production of p4-siRNAs in B. rapa relative to Arabidopsis. B. rapa genomic regions are less likely to generate p4-siRNAs than Arabidopsis but more likely to generate Pol IV-independent siRNAs, including 24 nt RNAs mapping to transposable elements. These observations underscore the diversity of small RNAs produced by plants and highlight the importance of genetic studies during small RNA analysis.

  5. Tapaturmien ehkäisy ja hoito päiväkodissa - Tapaturmakartoitus päiväkoti Meripirtin hoitohenkilökunnalle


    Mäkinen, Ida; Käki, Elina


    Tämän opinnäytetyön tavoitteina oli selvittää, minkälaisia tapaturmia leikki-ikäiselle lapselle päiväkodissa tapahtuu, miten henkilökunta osaa toimia tapaturmatilanteissa sekä mitkä puutteet nousevat esille Kotkassa sijaitsevan päiväkoti Meripirtin henkilökunnan tapaturmatilanteiden hallinnassa. Tavoitteena oli myös luoda päiväkodille tapaturmien ehkäisy- ja hoito-ohjeita sisältävä kansio. Ohjekansion tavoitteena oli lisätä hoitohenkilökunnan tietoa lasten tilastollisesti yleisimpien tapaturm...

  6. An efficient strategy for heterologous expression and purification of active peptide hainantoxin-IV.

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    Hui Zhang

    Full Text Available Hainantoxin-IV (HNTX-IV from the venom of the spider Selenocosmia hainana is a potent antagonist that specifically inhibits the tetrodotoxin-sensitive (TTX-S sodium channels. The toxin peptide consists of 35 amino acids and adopts a typical inhibitory cystine knot (ICK motif. To obtain adequate HNTX-IV peptides for further insight into the structure-activity relationships of the toxin, a novel strategy including cloning, expression and purification was developed in an E. coli expression system. For this purpose, a seamless restriction-free (RF cloning method was employed for the construction of an expression vector to avoid introducing unwanted sequences into the target gene. Furthermore, the solubility of recombinant HNTX-IV could be promoted efficiently by the combination of a glutathione S-transferase (GST tag and a small ubiquitin-related modifier (SUMO tag. Finally, an affinity-chromatography-free purification strategy was developed by cut-off dialysis tubing combined with trichloroacetic acid (TCA extraction. Further HPLC purification yielded recombinant, tag-free HNTX-IV with high yield and purity. The molecular weight of recombinant HNTX-IV (rHNTX-IV is identical to its theoretical value according to Matrix-Assisted Laser Desorption / Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS analysis. The recombinant toxin has similar activity (IC50 value of 120 nM on the tetrodotoxin-sensitive (TTX-S sodium channels in adult rat dorsal root ganglion (DRG neurons to native toxins. In the report, an efficient and cost-effective strategy for producing rHNTX-IV was developed, which paved the way for the further study of structure-activity relationships of rHNTX-IV and its pharmaceutical applications.

  7. Formation of uranium(IV)-silica colloids at near-neutral pH (United States)

    Dreissig, Isabell; Weiss, Stephan; Hennig, Christoph; Bernhard, Gert; Zänker, Harald


    Evidence is provided by photon correlation spectroscopy, ultrafiltration and ultracentrifugation that uranium(IV) can form silicate-containing colloids of a size of ⩽20 nm. A concentration of up to 10 -3 M of colloid-borne U(IV) was observed. The particles are generated in near-neutral to slightly alkaline solutions containing background chemicals of geogenic nature (carbonate, silicate, sodium ions). They remain stable in aqueous suspension over years. Electrostatic repulsion due to a negative zeta potential in the near-neutral to alkaline pH range caused by the silicate stabilizes the U(IV) colloids. The isoelectric point of the nanoparticles is shifted toward lower pH values by the silicate. The mechanism of the colloidal stabilization can be regarded as "sequestration" by silicate, a phenomenon well known from heavy metal ions of high ion potential such as iron(III) or manganese(III,IV), but never reported for uranium(IV) so far. Extended X-ray absorption fine structure (EXAFS) spectroscopy showed that U-O-Si bonds, which increasingly replace the U-O-U bonds of the amorphous uranium(IV) oxyhydroxide with increasing silicate concentrations, make up the internal structure of the colloids. The next-neighbor coordination of U(IV) in the U(IV)-silica colloids is comparable with that of coffinite, USiO 4. The assessment of uranium behavior in the aquatic environment should take the possible existence of U(IV)-silica colloids into consideration. Their occurrence might influence uranium migration in anoxic waters.

  8. Predicting multiplanar cervical spine injury due to head-turned rear impacts using IV-NIC. (United States)

    Ivancic, Paul C; Panjabi, Manohar M; Tominaga, Yasuhiro; Malcolmson, George F


    Intervertebral Neck Injury Criterion (IV-NIC) hypothesizes that dynamic three-dimensional intervertebral motion beyond physiological limit may cause multiplanar soft-tissue injury. Present goals, using biofidelic whole human cervical spine model with muscle force replication and surrogate head in head-turned rear impacts, were to: (1) correlate IV-NIC with multiplanar injury, (2) determine IV-NIC injury threshold at each intervertebral level, and (3) determine time and mode of dynamic intervertebral motion that caused injury. Impacts were simulated at 3.5, 5, 6.5, and 8 g horizontal accelerations of T1 vertebra (n = 6; average age: 80.2 years; four male, two female donors). IV-NIC was defined at each intervertebral level and in each motion plane as dynamic intervertebral rotation divided by physiological limit. Three-plane pre- and post-impact flexibility testing measured soft-tissue injury; that is significant increase in neutral zone (NZ) or range of motion (RoM) at any intervertebral level, above baseline. IV-NIC injury threshold was average IV-NIC peak at injury onset. IV-NIC extension peaks correlated best with multiplanar injuries (P NIC injury thresholds ranged between 1.1 at C0-C1 and C3-C4 to 2.9 at C7-T1. IV-NIC injury threshold times were attained between 83.4 and 150.1 ms following impact. Correlation between IV-NIC and multiplanar injuries demonstrated that three-plane intervertebral instability was primarily caused by dynamic extension beyond the physiological limit during head-turned rear impacts.

  9. Distribution of Basement Membrane Molecules, Laminin and Collagen Type IV, in Normal and Degenerated Cartilage Tissues (United States)

    Toh, Wei Seong; Gomoll, Andreas H.; Olsen, Bjørn Reino; Spector, Myron


    Objective: The objective of the present study was to investigate the presence and distribution of 2 basement membrane (BM) molecules, laminin and collagen type IV, in healthy and degenerative cartilage tissues. Design: Normal and degenerated tissues were obtained from goats and humans, including articular knee cartilage, the intervertebral disc, and meniscus. Normal tissue was also obtained from patella-tibial enthesis in goats. Immunohistochemical analysis was performed using anti-laminin and anti–collagen type IV antibodies. Human and goat skin were used as positive controls. The percentage of cells displaying the pericellular presence of the protein was graded semiquantitatively. Results: When present, laminin and collagen type IV were exclusively found in the pericellular matrix, and in a discrete layer on the articulating surface of normal articular cartilage. In normal articular (hyaline) cartilage in the human and goat, the proteins were found co-localized pericellularly. In contrast, in human osteoarthritic articular cartilage, collagen type IV but not laminin was found in the pericellular region. Nonpathological fibrocartilaginous tissues from the goat, including the menisci and the enthesis, were also positive for both laminin and collagen type IV pericellularly. In degenerated fibrocartilage, including intervertebral disc, as in degenerated hyaline cartilage only collagen type IV was found pericellularly around chondrocytes but with less intense staining than in non-degenerated tissue. In calcified cartilage, some cells were positive for laminin but not type IV collagen. Conclusions: We report differences in expression of the BM molecules, laminin and collagen type IV, in normal and degenerative cartilaginous tissues from adult humans and goats. In degenerative tissues laminin is depleted from the pericellular matrix before collagen type IV. The findings may inform future studies of the processes underlying cartilage degeneration and the functional

  10. Evidence for a Di-μ-oxo Diamond Core in the Mn(IV)/Fe(IV) Activation Intermediate of Ribonucleotide Reductase from Chlamydia trachomatis. (United States)

    Martinie, Ryan J; Blaesi, Elizabeth J; Krebs, Carsten; Bollinger, J Martin; Silakov, Alexey; Pollock, Christopher J


    High-valent iron and manganese complexes effect some of the most challenging biochemical reactions known, including hydrocarbon and water oxidations associated with the global carbon cycle and oxygenic photosynthesis, respectively. Their extreme reactivity presents an impediment to structural characterization, but their biological importance and potential chemical utility have, nevertheless, motivated extensive efforts toward that end. Several such intermediates accumulate during activation of class I ribonucleotide reductase (RNR) β subunits, which self-assemble dimetal cofactors with stable one-electron oxidants that serve to initiate the enzyme's free-radical mechanism. In the class I-c β subunit from Chlamydia trachomatis, a heterodinuclear Mn(II)/Fe(II) complex reacts with dioxygen to form a Mn(IV)/Fe(IV) intermediate, which undergoes reduction of the iron site to produce the active Mn(IV)/Fe(III) cofactor. Herein, we assess the structure of the Mn(IV)/Fe(IV) activation intermediate using Fe- and Mn-edge extended X-ray absorption fine structure (EXAFS) analysis and multifrequency pulse electron paramagnetic resonance (EPR) spectroscopy. The EXAFS results reveal a metal-metal vector of 2.74-2.75 Å and an intense light-atom (C/N/O) scattering interaction 1.8 Å from the Fe. Pulse EPR data reveal an exchangeable deuterium hyperfine coupling of strength |T| = 0.7 MHz, but no stronger couplings. The results suggest that the intermediate possesses a di-μ-oxo diamond core structure with a terminal hydroxide ligand to the Mn(IV).

  11. Vanhempien kokemuksia lapsen psykososiaalisesta kehityksestä vuoropäivähoidossa


    Jaakkola, Johanna; Takkinen, Reeta


    Jaakkola, Johanna & Takkinen, Reeta. Vanhempien kokemuksia lapsen psykososiaalisesta kehityksestä vuoropäivähoidossa. Oulu, kevät 2011, 49 s. 2 liitettä. Diakonia-ammattikorkeakoulu, Diak Pohjoinen Oulu. Sosiaalialan koulutusohjelma, sosionomi (AMK). Opinnäytetyömme tavoitteena oli tuoda esille vanhempien kokemuksia lapsen psykososiaalisesta kehityksestä vuoropäivähoidossa. Opinnäytetyön tarkoituksena oli kehittää käytännön työtä vuoropäiväkodissa sekä lisätä omaa ammatillista osaamis...

  12. Maahanmuuttajavanhempien kokemuksia päivähoidosta Mikkelissä


    Manninen, Inni


    KUVAILULEHTI Opinnäytetyön päivämäärä 25.1.2011 Tekijä(t) Inni Manninen Koulutusohjelma ja suuntautuminen Sosiaalialan koulutusohjelma, Sosionomi (AMK) Nimeke Maahanmuuttajavanhempien kokemuksia päivähoidosta Mikkelissä Tiivistelmä Tässä opinnäytetyössä kartoitetaan maahanmuuttajavanhempien kokemuksia päivähoidosta Mikkelissä. Opinnäytetyössä halutaan tuoda esille kasvatuskumppanuus maahanmuuttajavanhemman näkökulmasta. Enemmän on tehty opinnäytetöitä p...

  13. Understanding Humic Acid / Zr(IV) Interaction — A Spectromicroscopy Approach (United States)

    Rothe, Jörg; Plaschke, Markus; Denecke, Melissa A.


    Complexation of Zr(IV) by humic acid (HA) and polyacrylic acid (PAA) is investigated from the point of view of the organic ligand. STXM Spectromicroscopy and C 1s-NEXAFS point to different interaction mechanisms between Zr(IV) cations and oxo/hydroxo colloids and PAA. Under conditions where the metal aquo ion is stable, strong complexes are formed. In contrast, unspecific surface coating is identified when PAA is contacted with Zr(IV) oxo/hydroxide colloids. HA exhibits similar C 1s-NEXAFS features indicating a complexation reaction.

  14. Acid-base properties of sorbents based on zirconium(IV) phosphates

    Energy Technology Data Exchange (ETDEWEB)

    Bekrenev, A.V. [Research Center of Environmental Safety, St. Petersburg (Russian Federation); Pyartman, A.K. [St. Petersburg Institute of Technology (Russian Federation)


    The objective of this work was to investigate the acid-base properties of materials based on zirconium(IV) phosphate and diphosphate and to calculate the equilibrium constants for corresponding heterogeneous reactions of binary ion exchange, that is, to calculate the characteristics of the ion-exchange properties for use in calculating more complicated ion-exchange equilibria. The objects of investigation were zirconium(IV) hydroxyphosphate (ZHP) and zirconium(IV) diphosphate (ZDP), as well as composite materials based on said compounds and a porous support material.

  15. Influence of shelf life on the setting time of type IV gypsum (United States)

    Hapsari, M. L.; Irawan, B.; Damiyanti, M.


    Although expired materials can exhibit a deterioration in their properties, expired type IV gypsum can still be found on the market. In order to evaluate the influence of the shelf life on its setting time, two groups of type IV gypsum (GC Fuji rock EP) with different expiration dates were used in this research. The setting time tests were done in a mold using a Vicat Needle apparatus. The results of the statistical analysis showed a significant difference (p<0.05) between the two different expiration date groups. Therefore, the shelf life did influence the setting time of the type IV gypsum.

  16. Mahdollisuus vaikuttaa : Kauhanojan päiväkodin lasten vanhempien kokemuksia vaikuttamisesta varhaiskasvatuksessa


    Järvenpää, Marjaana


    Tämän tutkimuksellisen opinnäytetyön tarkoituksena on selvittää vanhempien mahdollisuuksia vaikuttaa Loimaan kaupungin Kauhanojan päiväkodin varhaiskasvatukseen. Tavoitteena on kasvatusyhteistyön parantaminen päiväkodin ja kodin välillä sekä päiväkodin toiminnan kehittäminen. Vaikuttaminen varhaiskasvatuksen toimintaan luo mahdollisuuden vanhemmille osallisuuden kokemiseen. Selvitän haastattelututkimuksen avulla neljän vanhemman kokemuksia varhaiskasvatukseen vaikuttamisesta, kasvatusyhteisty...

  17. Solvent extraction separation of zirconium(IV) with macrobicyclic polyether from chloride media

    Energy Technology Data Exchange (ETDEWEB)

    Mathev, V.J.; Khopkar, S.M. [University of Bombay, Bombay (India)


    Zirconium(IV) was qualitatively extracted at pH 3.4 with 0.01 mol l{sup -1} cryptand 2.2.2 in chloroform. From the organic phase zirconium(IV) was stripped with 1 mol l{sup -1} nitric acid and was subsequently determined spectrophotometrically at 385 nm as a complex with 8-hydroxyquinoline. Zirconium(IV) was separated from large number of anions and transition metals in binary as well as in the multicomponent mixtures. 11 refs, 1 fig., 5 tabs.

  18. Effects of Temperature Dependence of Energy Bandgap on I-V Characteristics in CNTFETs Models (United States)

    Marani, R.; Perri, A. G.

    In this paper, we analyze the effects of temperature dependence of energy bandgap on I-V characteristics in some carbon nanotube field effect transistors (CNTFETs) models proposed in literature in order to identify the one more suitable for computer aided design (CAD) applications. At first we consider a compact, semi-empirical model, already proposed by us, performing I-V characteristic simulations at different temperatures. Our results are compared with those obtained with the Stanford-Source virtual carbon nanotube field-effect transistor model (VS-CNFET), obtaining I-V characteristics comparable, but with lower CPU calculation time.

  19. Mechanism of C-F reductive elimination from palladium(IV) fluorides. (United States)

    Furuya, Takeru; Benitez, Diego; Tkatchouk, Ekaterina; Strom, Alexandra E; Tang, Pingping; Goddard, William A; Ritter, Tobias


    The first systematic mechanism study of C-F reductive elimination from a transition metal complex is described. C-F bond formation from three different Pd(IV) fluoride complexes was mechanistically evaluated. The experimental data suggest that reductive elimination occurs from cationic Pd(IV) fluoride complexes via a dissociative mechanism. The ancillary pyridyl-sulfonamide ligand plays a crucial role for C-F reductive elimination, likely due to a kappa(3) coordination mode, in which an oxygen atom of the sulfonyl group coordinates to Pd. The pyridyl-sulfonamide can support Pd(IV) and has the appropriate geometry and electronic structure to induce reductive elimination.

  20. Mechanism of C–F Reductive Elimination from Palladium(IV) Fluorides (United States)

    Furuya, Takeru; Benitez, Diego; Tkatchouk, Ekaterina; Strom, Alexandra E.; Tang, Pingping; Goddard, William A.; Ritter, Tobias


    The first systematic mechanism study of C–F reductive elimination from a transition metal complex is described. C–F bond formation from three different Pd(IV) fluoride complexes was mechanistically evaluated. The experimental data suggest that reductive elimination occurs from cationic Pd(IV) fluoride complexes via a dissociative mechanism. The ancillary pyridyl-sulfonamide ligand plays a crucial role for C–F reductive elimination, likely due to a κ3 coordination mode, in which an oxygen atom of the sulfonyl group coordinates to Pd. The pyridyl-sulfonamide can support Pd(IV) and has the appropriate geometry and electronic structure to induce reductive elimination. PMID:20196595

  1. Electrocatalytic Oxidation and Determination of Cysteine at Oxovanadium(IV Salen Coated Electrodes

    Directory of Open Access Journals (Sweden)

    Piyush Kumar Sonkar


    Full Text Available A transition metal complex, oxovanadium(IV salen (where salen represents N,N′-bis(salicylideneethylenediamine is immobilized on glassy carbon (GC electrodes and utilized for electrocatalytic oxidation of cysteine. In presence of oxovanadium(IV salen, increased oxidation current is observed due to the effective oxidation of cysteine by the electrogenerated oxovanadium(V salen species. The oxidation current linearly varies with the concentration of cysteine from 0.1 to 1.0 mM. The modified electrode has good sensitivity and low limit of detection. These properties make the oxovanadium(IV salen as an effective electrocatalyst for the determination of cysteine.

  2. 75 FR 26747 - Meadow Lake Wind Farm IV LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes... (United States)


    ...] Meadow Lake Wind Farm IV LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...-referenced proceeding of Meadow Lake Wind Farm IV LLC's application for market-based rate authority, with an...

  3. U.S. Level III and IV Ecoregions (U.S. EPA) (United States)

    U.S. Environmental Protection Agency — This map service displays Level III and Level IV Ecoregions of the United States and was created from ecoregion data obtained from the U.S. Environmental Protection...

  4. Removal of thorium(IV) from aqueous solutions by natural sepiolite

    Energy Technology Data Exchange (ETDEWEB)

    Erden, Kadriye Esen [Pamukkale Univ., Denizli (Turkey). Dept. of Electricity and Energy; Donat, Ramazan [Pamukkale Univ., Denizli (Turkey). Dept. of Chemistry


    Natural sepiolite has been tested as a potential sorbent for the removal of Th(IV) from aqueous solutions by batch technique. Effects of various parameters on the adsorption process have been investigated. Under optimum conditions, Th(IV) was adsorbed with high adsorption efficiency. The results indicated that sorption of Th(IV) on sepiolite was strongly affected by pH values and temperature. The adsorption patterns of thorium on the sepiolite adsorbent followed the Langmuir, Freundlich and Dubinin-Radushkevich (D-R) isotherms. The thermodynamic data (ΔH , ΔS , ΔG ) are calculated from the temperature-dependent sorption isotherms. The results suggest that sorption process of Th(IV) on sepiolite is spontaneous and endothermic.

  5. Oxyhydroxy Silicate Colloids: A New Type of Waterborne Actinide(IV) Colloids (United States)

    Weiss, Stephan; Hennig, Christoph; Brendler, Vinzenz; Ikeda‐Ohno, Atsushi


    Abstract At the near‐neutral and reducing aquatic conditions expected in undisturbed ore deposits or in closed nuclear waste repositories, the actinides Th, U, Np, and Pu are primarily tetravalent. These tetravalent actinides (AnIV) are sparingly soluble in aquatic systems and, hence, are often assumed to be immobile. However, AnIV could become mobile if they occur as colloids. This review focuses on a new type of AnIV colloids, oxyhydroxy silicate colloids. We herein discuss the chemical characteristics of these colloids and the potential implication for their environmental behavior. The binary oxyhydroxy silicate colloids of AnIV could be potentially more mobile as a waterborne species than the well‐known mono‐component oxyhydroxide colloids. PMID:27957406

  6. Narrative report: Calendar year 1972: Lake Ilo National Wildlife Refuge & Easement Refuges - District IV (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Lake Ilo NWR and the District IV Easement Refuges outlines Refuge accomplishments during the 1972 calendar year. The report begins...

  7. Kaubamaja Lastemaailm IV korrusel = Children's World on the fourth floor of Tallinn Department Store

    Index Scriptorium Estoniae


    Lastemaailm Tallinna Kaumabaja IV korrusel Gonsiori tänav 2. Arhitektuuri Sihtkapitali äramärkimine 2012 visuaalselt atraktiivse ning kontseptuaalselt tervikliku laste- ja vanemasõbraliku fantaasiamaailma loomise eest. Sisearhitektid Janno Roos, Andres Labi, Liisa Põime (Ruumilabor)

  8. MEBES IV: a new generation raster-scan electron-beam lithography system (United States)

    Abboud, Frank E.; Poreda, John T.; Smith, Robert L.


    The MEBES IV Electron Beam Lithography System was developed to meet requirements for advanced maskmaking. This necessitates support of 16- and 64-Mbit DRAM production and early development of 256-Mbit DRAMs. Using the original MEBES concepts and Etec's many years of experience with MEBES manufacturing, several major subsystems were redesigned, including the electron beam column and electron source. New test methods and test patterns were also developed to characterize system performance. As a result of the combined efforts of Etec Manufacturing and Engineering, a number of MEBES IV systems have already been built and tested. This paper provides a brief description of the MEBES IV systems. The new test patterns and methods are discussed. System performance data collected during factory acceptance of MEBES IV-LaB6 and -TFE (thermal field emission) systems are also presented.

  9. Tuning reactivity and mechanism in oxidation reactions by mononuclear nonheme iron(IV)-oxo complexes. (United States)

    Nam, Wonwoo; Lee, Yong-Min; Fukuzumi, Shunichi


    Mononuclear nonheme iron enzymes generate high-valent iron(IV)-oxo intermediates that effect metabolically important oxidative transformations in the catalytic cycle of dioxygen activation. In 2003, researchers first spectroscopically characterized a mononuclear nonheme iron(IV)-oxo intermediate in the reaction of taurine: α-ketogultarate dioxygenase (TauD). This nonheme iron enzyme with an iron active center was coordinated to a 2-His-1- carboxylate facial triad motif. In the same year, researchers obtained the first crystal structure of a mononuclear nonheme iron(IV)-oxo complex bearing a macrocyclic supporting ligand, [(TMC)Fe(IV)(O)](2+) (TMC = 1,4,8,11-tetramethyl-1,4,8,11-tetraazacyclotetradecene), in studies that mimicked the biological enzymes. With these breakthrough results, many other studies have examined mononuclear nonheme iron(IV)-oxo intermediates trapped in enzymatic reactions or synthesized in biomimetic reactions. Over the past decade, researchers in the fields of biological, bioinorganic, and oxidation chemistry have extensively investigated the structure, spectroscopy, and reactivity of nonheme iron(IV)-oxo species, leading to a wealth of information from these enzymatic and biomimetic studies. This Account summarizes the reactivity and mechanisms of synthetic mononuclear nonheme iron(IV)-oxo complexes in oxidation reactions and examines factors that modulate their reactivities and change their reaction mechanisms. We focus on several reactions including the oxidation of organic and inorganic compounds, electron transfer, and oxygen atom exchange with water by synthetic mononuclear nonheme iron(IV)-oxo complexes. In addition, we recently observed that the C-H bond activation by nonheme iron(IV)-oxo and other nonheme metal(IV)-oxo complexes does not follow the H-atom abstraction/oxygen-rebound mechanism, which has been well-established in heme systems. The structural and electronic effects of supporting ligands on the oxidizing power of iron(IV

  10. Math anxiety differentially affects WAIS-IV arithmetic performance in undergraduates. (United States)

    Buelow, Melissa T; Frakey, Laura L


    Previous research has shown that math anxiety can influence the math performance level; however, to date, it is unknown whether math anxiety influences performance on working memory tasks during neuropsychological evaluation. In the present study, 172 undergraduate students completed measures of math achievement (the Math Computation subtest from the Wide Range Achievement Test-IV), math anxiety (the Math Anxiety Rating Scale-Revised), general test anxiety (from the Adult Manifest Anxiety Scale-College version), and the three Working Memory Index tasks from the Wechsler Adult Intelligence Scale-IV Edition (WAIS-IV; Digit Span [DS], Arithmetic, Letter-Number Sequencing [LNS]). Results indicated that math anxiety predicted performance on Arithmetic, but not DS or LNS, above and beyond the effects of gender, general test anxiety, and math performance level. Our findings suggest that math anxiety can negatively influence WAIS-IV working memory subtest scores. Implications for clinical practice include the utilization of LNS in individuals expressing high math anxiety.

  11. Item Response Theory Analysis of DSM-IV Cannabis Abuse and Dependence Criteria in Adolescents (United States)

    Hartman, Christie A.; Gelhorn, Heather; Crowley, Thomas J.; Sakai, Joseph T.; Stallings, Michael; Young, Susan E.; Rhee, Soo Hyun; Corley, Robin; Hewitt, John K.; Hopfer, Christian J.


    A study to examine the DSM-IV criteria for cannabis abuse and dependence among adolescents is conducted. Results conclude that abuse and dependence criteria were not found to affect the different levels of severity in cannabis use.

  12. Comportamiento del concreto con bajos porcentajes de ceniza volante (termopaipa IV) y agua constante

    National Research Council Canada - National Science Library

    Luz Elena Santaella Valencia; Rodrigo Salamanca Correa


    Este artículo se realiza con base en el trabajo de grado titulado Influencia de la ceniza volante procedente de Termopaipa IV adicionada en bajos porcentajes al concreto desarrollada por los estudiantes Milena Puerta...

  13. Rapid IV Versus Oral Rehydration: Responses to Subsequent Exercise Heat Stress

    National Research Council Canada - National Science Library

    Kenefick, Robert W; O'Moore, Kathleen M; Mahood, Nicholas V; Castellani, John W


    This study sought to determine the effect of rapid intravenous (IV) versus oral (ORAL) rehydration immediately after dehydration, on cardiovascular, thermoregulatory, and perceptual responses during subsequent exercise in the heat.

  14. DSM-IV Diagnoses and Obstructive Sleep Apnea in Children Before and 1 Year after Adenotonsillectomy (United States)

    Dillon, James E.; Blunden, Sarah; Ruzicka, Deborah L.; Guire, Kenneth E.; Champine, Donna; Weatherly, Robert A.; Hodges, Elise K.; Giordani, Bruno J.; Chervin, Ronald D.


    DSM-IV criteria-based psychiatric diagnoses done in children before and one year after adenotonsillectomy are assessed to record any improvement in behavior. It is found that surgery might be associated with reduced behavioral morbidity.

  15. A Chiral, Photoluminescent, and Spin-Canted {Cu(I)Re(IV)2}n Branched Chain. (United States)

    Martínez-Lillo, José; Armentano, Donatella; Fortea-Pérez, Francisco R; Stiriba, Salah-Eddine; De Munno, Giovanni; Lloret, Francesc; Julve, Miguel; Faus, Juan


    A new heteroleptic 1D Cu(I)-Re(IV) coordination polymer of the formula {Cu(I)Re(IV)Cl4(μ-Cl)(μ-pyz)[Re(IV)Cl4(μ-bpym)]}n·nMeNO2 (1; pyz = pyrazine, bpym = 2,2'-bipyrimidine) has been prepared through the Cu(I)-mediated self-assembly of two different Re(IV) metalloligands, namely, [ReCl5(pyz)](-) and [ReCl4(bpym)]. 1 consists of chiral branched chains with an overall rack-type architecture displaying photoemission and magnetic ordering. These results constitute a first step toward making new multifunctional magnetic materials based on mixed 3d-5d molecular systems.

  16. 31. III - 3. IV toimub Helsingis ja Tallinnas rahvusvaheline kunstihoonete konverents "Concrete Visions"

    Index Scriptorium Estoniae


    Konverentsi eesmärgist, osalejatest. 3. IV avatud paneeldiskussioonil arutletakse Tallinna Kunstihoones kunstihoone kui institutsiooni rolli ja näituste korraldamise ning Viinistu kunstimuuseumis kunstihoonete koostöö üle

  17. Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants

    DEFF Research Database (Denmark)

    Klausen, M.; Heydorn, Arne; Ragas, Paula Cornelia


    Biofilm formation by Gfp-tagged Pseudomonas aeruginosa PAO1 wild type, flagella and type IV pili mutants in flow chambers irrigated with citrate minimal medium was characterized by the use of confocal laser scanning microscopy and comstat image analysis. Flagella and type IV pili were not necessary...... for P. aeruginosa initial attachment or biofilm formation, but the cell appendages had roles in biofilm development, as wild type, flagella and type IV pili mutants formed biofilms with different structures. Dynamics and selection during biofilm formation were investigated by tagging the wild type...... and flagella/type IV mutants with Yfp and Cfp and performing time-lapse confocal laser scanning microscopy in mixed colour biofilms. The initial microcolony formation occurred by clonal growth, after which wild-type P. aeruginosa bacteria spread over the substratum by means of twitching motility. The wild-type...

  18. A study on adsorptivity of monoamide resins to U(IV) in HNO{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Masanobu Nogami; Yuichi Sugiyama; Yasuhisa Ikeda [Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology, 2-12-1-N1-34 O-okayama, Meguro-ku, Tokyo 152-8550 (Japan)


    As a part of the development of resins with selectivity for U(VI) in HNO{sub 3} media, adsorptivities of some silica-supported monoamide resins to U(IV) in HNO{sub 3} solutions were examined. It was found that Silica-DMAA resins consisting of N,N-dimethyl-acrylamide showed higher selectivities for U(VI) than for U(IV) under all the concentration range of HNO{sub 3}. On the other hand, Silica-MVBAA resin consisting of N-methyl- N-vinyl-benzyl-acetamide was found to show a higher selectivity for U(IV) in HNO{sub 3} solutions higher than ca. 3M (=mol/dm{sup 3}). The difference in the selectivity for U(IV) and U(VI) was explained by the steric hindrance on the complexation between the functional carbonyl groups of the monoamides and uranium species. (authors)


    Energy Technology Data Exchange (ETDEWEB)

    William E. Kastenberg; Edward Blandford; Lance Kim


    This project has developed quantitative safety goals for Generation IV (Gen IV) nuclear energy systems. These safety goals are risk based and technology independent. The foundations for a new approach to risk analysis has been developed, along with a new operational definition of risk. This project has furthered the current state-of-the-art by developing quantitative safety goals for both Gen IV reactors and for the overall Gen IV nuclear fuel cycle. The risk analysis approach developed will quantify performance measures, characterize uncertainty, and address a more comprehensive view of safety as it relates to the overall system. Appropriate safety criteria are necessary to manage risk in a prudent and cost-effective manner. This study is also important for government agencies responsible for managing, reviewing, and for approving advanced reactor systems because they are charged with assuring the health and safety of the public.

  20. Talimogene Laherparepvec and Pembrolizumab in Treating Patients With Stage III-IV Melanoma (United States)


    Recurrent Melanoma; Stage III Cutaneous Melanoma AJCC v7; Stage IIIA Cutaneous Melanoma AJCC v7; Stage IIIB Cutaneous Melanoma AJCC v7; Stage IIIC Cutaneous Melanoma AJCC v7; Stage IV Cutaneous Melanoma AJCC v6 and v7