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Sample records for vibroacoustic diagnostic monitoring

  1. Vibroacoustic diagnostic monitoring of selected primary coolant circuit components of the Bohunice V-1 nuclear power plant

    Energy Technology Data Exchange (ETDEWEB)

    Bahna, J.; Jaros, I. (Forschungsinstitut fuer Kernkraftwerke, Jaslovske Bohunice (Czechoslovakia))

    1983-02-01

    An information is given about vibroacoustic monitoring systems installed at the two units of the Bohunice V-1 nuclear power plant for oscillation monitoring of the reactor coolant pumps and reactor pressure vessel. Signal processing and analysis techniques have been developed for diagnostic measurements. It is reported on some experience gained from oscillation measurements at the reactor coolant pumps of the V-1 nuclear power plant since commissioning of the plant.

  2. Vibro-acoustic condition monitoring of Internal Combustion Engines: A critical review of existing techniques

    Science.gov (United States)

    Delvecchio, S.; Bonfiglio, P.; Pompoli, F.

    2018-01-01

    This paper deals with the state-of-the-art strategies and techniques based on vibro-acoustic signals that can monitor and diagnose malfunctions in Internal Combustion Engines (ICEs) under both test bench and vehicle operating conditions. Over recent years, several authors have summarized what is known in critical reviews mainly focused on reciprocating machines in general or on specific signal processing techniques: no attempts to deal with IC engine condition monitoring have been made. This paper first gives a brief summary of the generation of sound and vibration in ICEs in order to place further discussion on fault vibro-acoustic diagnosis in context. An overview of the monitoring and diagnostic techniques described in literature using both vibration and acoustic signals is also provided. Different faulty conditions are described which affect combustion, mechanics and the aerodynamics of ICEs. The importance of measuring acoustic signals, as opposed to vibration signals, is due since the former seem to be more suitable for implementation on on-board monitoring systems in view of their non-intrusive behaviour, capability in simultaneously capturing signatures from several mechanical components and because of the possibility of detecting faults affecting airborne transmission paths. In view of the recent needs of the industry to (-) optimize component structural durability adopting long-life cycles, (-) verify the engine final status at the end of the assembly line and (-) reduce the maintenance costs monitoring the ICE life during vehicle operations, monitoring and diagnosing system requests are continuously growing up. The present review can be considered a useful guideline for test engineers in understanding which types of fault can be diagnosed by using vibro-acoustic signals in sufficient time in both test bench and operating conditions and which transducer and signal processing technique (of which the essential background theory is here reported) could be

  3. Monitoring of the stress-strain state of the surface layer of a part in the cutting process using vibroacoustic diagnostics

    Directory of Open Access Journals (Sweden)

    Allenov Dmitry

    2017-01-01

    Full Text Available The state of the surface layer after mechanical process influences on the performance characteristics of the parts: corrosion and fatigue resistance, dimensional stability during the operating time. The wear of tools can have a decisive influence on the surface deformation. The present paper is devoted to monitoring the influence of wear on the surface layer using the analysis of vibration signals.

  4. Feasibility of using vibroacoustic monitoring for assessment of technical condition of hoist drives

    Energy Technology Data Exchange (ETDEWEB)

    Spalek, J.; Fober, S. (Politechnika Slaska, Gliwice (Poland). Instytut Mechanizacji Gornictwa)

    1990-01-01

    Analyzes use of vibroacoustic testing of gears for hoists used in underground coal mining. Accuracy of vibroacoustic testing is evaluated on the example of 4 hoists used in the Katowice black coal mine (in a main hoisting shaft, in an auxiliary shaft and in 2 blind shafts). Types of electric motors, their rated power and types of gears are compared. Effects of wear on vibroacoustic emission are analyzed. Design and use of a system for measuring vibroacoustic emission of gears are described. Measurement results are evaluated. Effects of damping mechanical vibrations and acoustic emission by individual elements of the mechanical transmissions on reliability and accuracy of vibroacoustic testing are analyzed. 10 refs.

  5. Computerized fetal heart rate monitoring after vibroacoustic stimulation in the anencephalic fetus.

    Science.gov (United States)

    Park, Yong-Jin; Park, Seon-Hye; Kim, Young-Jae; Hoh, Jeong-Kyu; Park, Young-Sun; Park, Moon-Il

    2010-09-01

    To quantify changes in fetal heart rate (FHR) parameters after vibroacoustic stimulation (VAS) and to evaluate the usefulness of VAS testing (VAST) in anencephalic fetuses. Our findings may also help to clarify the route(s) of vibration and sound transmission during VAST. We obtained the antepartum FHR tracings of 16 anencephalic fetuses, including both the nonstress test (NST) and VAST. Using a computerized monitoring system, HYFM, we determined all FHR parameters from data collected for 10 min before and 10 min after VAS, at successive gestational stages. We observed three false reactive responses at term. The false reactive rate for VAST (3/16) was higher than that for NST (1/16). No FHR parameters increased significantly after VAS except for the number of fetal movements (FM), which increased significantly in all gestational groups (25th-32nd and 33rd-40th weeks). These findings call attention to an increased probability of a false reactive response in VAST analysis, when the fetus is affected by a CNS disorder. Increased numbers of FM after VAS suggest that the vibratory pathway is more likely to elicit fetal response than the auditory pathway in this setting, and that the vibratory stimulation travels by subcortical rather than by cortical pathways. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  6. Evaluation of diagnostic thresholds dependability for tribologic signals received in the environment disturbed by vibroacoustic and functional signals

    Directory of Open Access Journals (Sweden)

    Lindstedt Paweł

    2015-12-01

    Full Text Available Determination of dependable diagnostic thresholds for tribologic signals received e.g. from antifriction bearings (in particular for insufficient number of measurements, only 4÷5 is a really difficult task due to complexity of working environment where such bearings are operated. Typical working environment for such objects must take account for operation time under various working conditions and accompanying (and disturbing signals, e.g. vibroacoustic ones. The sought assessment of the relationship between diagnostic signals and environmental noise can be determined from convolution of both diagnostic and environments signals that make up the complete set of received information. The convolution of these two series of signals can be obtained from an algorithm based on the Cauchy product. Then one has to find the coherence factor and the square of amplitude gain for the set of diagnostic signals with reference to various sets of signals received from environment, which makes it possible to evaluate cohesion of the investigated series of signals, thus their suitability to determine diagnostic threshold for tribologic signals intended for the analysis.

  7. A vibroacoustic diagnostic system as an element improving road transport safety.

    Science.gov (United States)

    Komorska, Iwona

    2013-01-01

    Mechanical defects of a vehicle driving system can be dangerous on the road. Diagnostic systems, which monitor operations of electric and electronic elements and devices of vehicles, are continuously developed and improved, while defects of mechanical systems are still not managed properly. This article proposes supplementing existing on-board diagnostics with a system of diagnosing selected defects to minimize their impact. It presents a method of diagnosing mechanical defects of the engine, gearbox and other elements of the driving system on the basis of a model of the vibration signal obtained adaptively. This method is suitable for engine valves, engine head gasket, main gearbox, joints, etc.

  8. Monitoring and diagnostics systems for nuclear power plant operating regimes

    Energy Technology Data Exchange (ETDEWEB)

    Abagyan, A.A.; Dmitriev, V.M.; Klebanov, L.A.; Kroshilin, A.E.; Larin, E.P.; Morozov, S.K.

    1988-05-01

    The development of new monitoring and diagnostics systems for Soviet reactors is discussed. An experimental test station is described where industrial operation of new experimental systems can be conducted for purposes of bringing their performance to the level of standard Soviet systems for monitoring reactor operation regimes and equipment resources. The requirements and parameters of the systems are described on a unit-by-unit basis, including the sensor reading monitoring unit, the vibroacoustic monitoring unit, the noise monitoring unit, the accident regime identification unit, and the nonstationary regime monitoring unit. Computer hardware and software requirements are discussed. The results of calculational and experimental research on two complex nonstationary regimes of reactor operation are given. The accident regimes identification unit for the VVER-1000 is analyzed in detail.

  9. Vibroacoustic diagnostics of main circulating pump of primary coolant circuit of WWER reactor power plant

    Energy Technology Data Exchange (ETDEWEB)

    Samarin, A.A.; Adamenkov, K.A.

    1983-02-01

    The theoretical foundations are briefly described of the method and the noise sources given. Measurements on the main circulating pumps of the Novovoronezh nuclear power plant have shown that the range of frequencies of structural noises of the main circulating pumps lies within 10 and 20,000 Hz. These vibrations and noise have a broad band random character and therefore the mathematical apparatus of the theory of random processes is used for processing measured data. The ''signature'' method is used for diagnostics of the main circulating pumps - this is an analytical method consisting in that the measured spectrum is compared with a spectrum measured in a failure-free state. Experience with practical applications shows that a poor state of the main circulating pump is always accompanied by changes in noise spectrum.

  10. Vibroacoustic Skin Diagnostics Modeling

    Directory of Open Access Journals (Sweden)

    Svetlana М. Yatsun

    2013-01-01

    Full Text Available The article deals with the mathematical modeling of biological diagnosis of complex heterogeneous structure (skin, using non-destructive control method. The mathematical model, describing interaction of the material with electrodynamic vibration generator and sensor system, controlling the propagation of small disturbances was developed. The influence of material model parameters on the spectrum in the course of the propagation of the surface disturbance

  11. Vibroacoustic disease.

    Science.gov (United States)

    Branco, N A A Castelo; Alves-Pereira, M

    2004-01-01

    Vibroacoustic disease (VAD) is a whole-body, systemic pathology, characterized by the abnormal proliferation of extra-cellular matrices, and caused by excessive exposure to low frequency noise (LFN). VAD has been observed in LFN-exposed professionals, such as, aircraft technicians, commercial and military pilots and cabin crewmembers, ship machinists, restaurant workers, and disk-jockeys. VAD has also been observed in several populations exposed to environmental LFN. This report summarizes what is known to date on VAD, LFN-induced pathology, and related issues. In 1987, the first autopsy of a deceased VAD patient was performed. The extent of LFN induced damage was overwhelming, and the information obtained is, still today, guiding many of the associated and ongoing research projects. In 1992, LFN-exposed animal models began to be studied in order to gain a deeper knowledge of how tissues respond to this acoustic stressor. In both human and animal models, LFN exposure causes thickening of cardiovascular structures. Indeed, pericardial thickening with no inflammatory process, and in the absence of diastolic dysfunction, is the hallmark of VAD. Depressions, increased irritability and aggressiveness, a tendency for isolation, and decreased cognitive skills are all part of the clinical picture of VAD. LFN is a demonstrated genotoxic agent, inducing an increased frequency of sister chromatid exchanges in both human and animal models. The occurrence of malignancies among LFN-exposed humans, and of metaplastic and displastic appearances in LFN-exposed animals, clearly corroborates the mutagenic outcome of LFN exposure. The inadequacy of currently established legislation regarding noise assessments is a powerful hindrance to scientific advancement. VAD can never be fully recognized as an occupational and environmental pathology unless the agent of disease--LFN--is acknowledged and properly evaluated. The worldwide suffering of LFN-exposed individuals is staggering and it is

  12. Vibroacoustic system for monitoring vibrations of heavy equipment with rotary elements

    Energy Technology Data Exchange (ETDEWEB)

    Lipowczan, A.; Rabsztyn, T.

    1983-03-01

    A system for continuous monitoring of mechanical vibrations of blowers for ventilation of underground coal mines is presented. Use of the system prevents damage to bearings and other damage caused by excessive mechanical vibrations of a blower wheel. The monitoring system uses the PPWa converter (developed by the Central Mining Institute in Poland) which transforms mechanical signals which characterize vibration intensity into electrical signals. The PPWa converters are used with amplifiers and other auxiliary equipment. Design of the continuous monitoring equipment is shown. The following types of converter systems are characterized: the PPWa-1, the PPWa-2, the PPWa-3, the PPWa-4, the PPWa-5 and the PPWa-6. Specifications of the 6 converters are shown in a table. Performance of the continuous monitoring systems for ventilation blowers in coal mines is evaluated. 4 references

  13. Skylab vibroacoustic test program

    Science.gov (United States)

    Jewell, R. E.

    1974-01-01

    Vibroacoustic testing was performed on the orbital workshop dynamic test article and the payload assembly, the two major elements of the Skylab payload. The testing was conducted on each of the Skylab elements separately in the reverberation chamber at the Johnson Space Center. The two test configurations were high fidelity flight article simulations. The testing was conducted in two phases; in the first phase, acoustic tests were performed at levels simulating the lift-off and atmospheric flight acoustic criteria. In the second phase, low frequency sinusoidal vibration tests were conducted to obtain modal response data. The objectives of the Skylab vibroacoustic test program were to: verify the vibration design and test criteria; qualify selected flight components to the vibroacoustic criteria; and verify analytical models used for dynamic load analyses. This paper describes the vibroacoustic testing and discusses the results.

  14. Automatic cough episode detection using a vibroacoustic sensor.

    Science.gov (United States)

    Mlynczak, Marcel; Pariaszewska, Katarzyna; Cybulski, Gerard

    2015-08-01

    Cough monitoring is an important element of the diagnostics of respiratory diseases. The European Respiratory Society recommends objective assessment of cough episodes and the search for methods of automatic analysis to make obtaining the quantitative parameters possible. The cough "events" could be classified by a microphone and a sensor that measures the vibrations of the chest. Analysis of the recorded signals consists of calculating the features vectors for selected episodes and of performing automatic classification using them. The aim of the study was to assess the accuracy of classification based on an artificial neural networks using vibroacoustic signals collected from chest. Six healthy, young men and eight healthy, young women carried out an imitated cough, hand clapping, speech and shouting. Three methods of parametrization were used to prepare the vectors of episode features - time domain, time-frequency domain and spectral modeling. We obtained the accuracy of 95% using artificial neural networks.

  15. Vibro-acoustics

    CERN Document Server

    Nilsson, Anders

    2015-01-01

    This three-volume book gives a thorough and comprehensive presentation of vibration and acoustic theories. Different from traditional textbooks which typically deal with some aspects of either acoustic or vibration problems, it is unique of this book to combine those two correlated subjects together. Moreover, it provides fundamental analysis and mathematical descriptions for several crucial phenomena of Vibro-Acoustics which are quite useful in noise reduction, including how structures are excited, energy flows from an excitation point to a sound radiating surface, and finally how a structure radiates noise to a surrounding fluid. Many measurement results included in the text make the reading interesting and informative. Problems/questions are listed at the end of each chapter and the solutions are provided. This will help the readers to understand the topics of Vibro-Acoustics more deeply. The book should be of interest to anyone interested in sound and vibration, vehicle acoustics, ship acoustics and inter...

  16. Vibroacoustic benchmarking; Vibroakustisches Benchmarking

    Energy Technology Data Exchange (ETDEWEB)

    Kaesler, R.; Prinzler, H. [Freudenberg Dichtungs- und Schwingungstechnik KG, Weinheim (Germany). Technische Entwicklungszentrum

    2000-03-01

    Improved driving comfort is one of the main enhancements in the automotive industry today. It affects not only the constructive design of a car and its equipment but also the vibroacoustic adaptation of the entire vehicle. For several years now, Freudenberg Dichtungs- und Schwingungstechnik has been benchmarking automobiles with respect to their vibroacoustic performance, with the aim of optimising the vibrational layout of engine mounting systems, chassis mounting concepts and finally the overall adaptation of the vehicle. The results of this benchmarking programme are listed according to vehicle class (luxury, mid-range, compact or subcompact class) and constitute an impressive vibroacoustic assessment of current developments in this field. (orig.) [German] Die Steigerung des Fahrkomforts gehoert zu den aktuellen Hauptentwicklungen der Fahrzeughersteller. Dies betrifft nicht nur die konstruktive Gestaltung und Ausstattung der Kraftfahrzeuge, sondern insbesondere die vibroakustische Abstimmung des Gesamtfahrzeugs. Freudenberg Dichtungs- und Schwingungstechnik fuehrte seit mehreren Jahren ein vibroakustisches Fahrzeug-Benchmarking durch, um die schwingungstechnische Auslegung von Aggregatelagerungssystem, Fahrwerklagerungskonzepten und in der Endstufe die Gesamtabstimmung zu optimieren. Die Ergebnisse werden nach Fahrzeugklassen (Luxus-, Mittel-, Kompaktklasse und Kleinwagen) geordnet und stellen eine vibroakustische Bestandsaufnahme der aktuellen Entwicklungen dar. (orig.)

  17. Maturation of Human Fetal Responses to Vibroacoustic Stimulation.

    Science.gov (United States)

    Kisilevsky, Barbara S.; And Others

    1992-01-01

    Fetuses received vibroacoustic stimulation while movement and heart rate were monitored. From 29 weeks, at least 83 percent of fetuses responded to stimulation with heart rate acceleration. Between 26 and 36 weeks, the percentage of fetuses responding to stimulation with movement increased from 58 to 100 percent. (BC)

  18. A Method of Abnormal States Detection Based on Adaptive Extraction of Transformer Vibro-Acoustic Signals

    Directory of Open Access Journals (Sweden)

    Liang Zou

    2017-12-01

    Full Text Available State monitoring is very important for the safe operation of high-voltage transformers. A non-contact vibro-acoustic detection method based on the Blind Source Separation (BSS was proposed in this paper to promote the development of transformer on-line monitoring technology. Firstly, the algorithm of Sparse Component Analysis (SCA was applied for the adaptive extraction of vibro-acoustic signals, which utilizes the sorted local maximum values of the potential function. Then, the operating states of the transformer were detected by analyzing the vibro-acoustic signal eigenvectors. Different conditions including running normally, increasing of transformer vibro-acoustic amplitude and changing of frequency component of transformer vibro-acoustic were simulated. Moreover, experiments were carried out in a 220 kV substation. The research results show that the number of mixed noise sources can be estimated and the transformer vibro-acoustic signal was always ranked first in the separation signals. The source signals were effectively separated from the mixed signals while all of the correlation coefficients are more than 0.98 and the quadratic residuals are less than −32 dB. As for the experiments, the vibro-acoustic signal was separated out successfully from two voice signals and two interference signals. The acoustic signal reflection is considered as the main cause of the signal interference, and the transformer volume source model is considered as the main reason of unstable vibro-acoustic signal amplitude. Finally, the simulated abnormal states of the transformer were well recognized and the state of the tested transformer was judged to be normal.

  19. Vibroacoustic testing of gear transmissions for hoist drives

    Energy Technology Data Exchange (ETDEWEB)

    Antoniak, J.; Spalek, J. (Politechnika Slaska, Gliwice (Poland). Instytut Mechanizacji Gornictwa)

    1990-01-01

    The drive system of a hoist used in the Knurow black coal mine in Poland was investigated using vibroacoustic testing. The system consisted of 2 electric motors each with a power of 1,300 kW (600 r.p.m.) and the GCD-17 gear transmission. Vibrations and acoustic emission generated by individual elements of the mechanical transmission (roller bearings, gear wheels etc.) are evaluated. Design and operation of a measuring system, site selection of measuring points, frequency range of vibrations generated by the bearings or gears are analyzed. Examples of vibration spectra are evaluated. Recommendations for use of vibroacoustic testing in diagnostics of heavy-duty mining equipment are made. 3 refs.

  20. Vibroacoustical analysis of rail vehicle

    Directory of Open Access Journals (Sweden)

    Králíček J.

    2007-11-01

    Full Text Available The article deals with the vibroacoustical analysis of rail vehicle and is the extension of the previously presented work “Modelování podvozku kolejového vozidla s poddajným rámem”. The vibroacoustical analysis uses the outcomes of the dynamical analysis of rail vehicle bogie i.e. surface velocities of the bogie frame to compute the acoustic power radiated by the bogie frame and forces acting in the bogie-body interface. The radiated power and the force spectra are then used as the excitation to the rail body model in the environment Auto-SEA to compute the interior acoustic quantities.

  1. Vibroacoustic: The challenges of a mission impossible?

    Science.gov (United States)

    Sestieri, Aldo; Carcaterra, Antonio

    2013-01-01

    Why it is difficult to solve a vibroacoustic problem; what are the hidden pitfalls that one is called to overcome; are there methods or techniques suggested in other fields of physics that can help to formulate an efficient vibroacoustic prediction model? The authors provide personal answers to these questions and suggest also a classification of the numerous prediction methods proposed in the literature.

  2. VIBROACOUSTIC DIAGNOSING OF DISTURBANCES IN THE CAR IGNITION SYSTEM BY AMPLITUDE ESTIMATES

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    Piotr CZECH

    2014-06-01

    Full Text Available An important issue in vibroacoustic examination of engines is a correct interpretation of complex measured signals by applying property methods of their processing. The main tasks in diagnostics include: separation of a useful vibroacoustic signal and selection of characteristic, damage-sensitive features of the processed signal. The paper presents an attempt of detecting disturbances in the ignition system by measuring vibrations and noise. The object of the tests was a four-cylinder engine of a Volkswagen Polo car with swept capacity 1,0 dm3, adjusted to alternative power supply with the use of LPG gas fuel

  3. Principles of vibroacoustic testing of technological equipment of nuclear power plant primary coolant circuit

    Energy Technology Data Exchange (ETDEWEB)

    Samarin, A.A.; Adamenkov, K.A.; Krasyuk, V.Y.; Nozdrin, G.N.; Ivanov, Y.S.; Pospelko, K.A.

    1982-04-01

    Main principles are discussed of noise analysis as is its inclusion in the system of inspecting technological equipment of nuclear power plant primary circuits. Vibrations and noise resulting as system response to external perturbations are used as diagnostic signals. The mathematical formulation of the problem is done, the sources of vibrations and noise are determined, and the possibilities are discussed of analyzing the vibroacoustic signal and the changes in frequency characteristics to diagnose equipment failure states. Experiences are outlined with the placement of transducers in the Novovoronezh Nuclear Power Plant, which considerably affects the quality of control. A flow chart is shown for the vibroacoustic testing organization, and main trends are indicated of the study of vibroacoustic testing systems in nuclear power plants.

  4. A Framework for Systematic Benchmarking of Monitoring and Diagnostic Systems

    Data.gov (United States)

    National Aeronautics and Space Administration — In this paper, we present an architecture and a formal framework to be used for systematic benchmarking of monitoring and diagnostic systems and for producing...

  5. Fetal tachyarrhythmia associated with vibroacoustic stimulation.

    Science.gov (United States)

    Laventhal, Naomi T; Dildy, Gary A; Belfort, Michael A

    2003-05-01

    Vibroacoustic stimulation is commonly used in antepartum fetal testing and has known benefits. Although the procedure has been deemed safe, questions have been raised as to potentially adverse effects, and the adult cardiology literature identifies a link between abrupt sound stimulation and severe tachyarrhythmias. A fetus with premature atrial contractions converted to supraventricular tachycardia immediately after vibroacoustic stimulation. The tachyarrhythmia spontaneously reverted to baseline after 4 minutes. The infant was treated for junctional reentry tachycardia at birth. Although the cardiac effects of vibroacoustic stimulation have previously been characterized as benign, the use of this modality may warrant restriction in the setting of known fetal arrhythmias.

  6. Technical note: simple vibroacoustic foetal stimulator.

    Science.gov (United States)

    Stojanović, D; Frković, A; Filiplić-Stojanović, H; Kirincić, N

    2001-01-01

    To build and test a simple vibroacoustic foetal stimulator. A vibroacoustic foetal stimulator was constructed and subjected to bench testing. Clinical trial was carried out in comparison to an electro laynx. Screening specificity of 98% and 100% sensitivity was achieved, with no decrease in specificity due to user's maladjustments. The device was characterized by simple use, maintenance and disinfection. The device is a good screening instrument for foetal health in prenatal care, despite its simplicity and low price.

  7. Problems of nuclear power facility vibroacoustic diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Ananiev, V.D. [Frank Lab. of Neutron Physics, Joint Inst. for Nuclear Research (FLNP, JINR), Dubna, Moscow (Russian Federation); Vinogradov, A.V. [Frank Lab. of Neutron Physics, Joint Inst. for Nuclear Research (FLNP, JINR), Dubna, Moscow (Russian Federation); Baranov, I.M. [The Russia Minatom Engineering Center of Nuclear Equipment Strength, Reliability and Lifetime (ECS MAE RDIPE), Moscow (Russian Federation); Syzarev, V.D. [The Russia Minatom Engineering Center of Nuclear Equipment Strength, Reliability and Lifetime (ECS MAE RDIPE), Moscow (Russian Federation); Menyailov, A.I. [Inst. for Problems in Mechanics, Russia Academy of Sciences (IPM RAS), Moscow (Russian Federation)

    1995-12-31

    Measurable vibrations and noise in reactor signals may, after proper processing, provide valuable information about the internal state of a reactor. A brief survey of certain algorithms for such processes is presented, including estiamtions of structure damping ratios; detection of restoring force non-linearity from the measured response of reactor elements and, as a result, finding the defect`s position; and location of the main sources of oscillation and vibration excitation. (orig.)

  8. Leda Beam Diagnostics Instrumentation Beam Position Monitors

    CERN Document Server

    Barr, D

    2000-01-01

    The Low Energy Demonstration Accelerator (LEDA) facility located at Los Alamos National Laboratory (LANL) accelerates protons to an energy of 6.7-MeV and current of 100-mA operating in either a pulsed or cw mode. Of key importance to the commissioning and operations effort is the Beam Position Monitor system (BPM). The LEDA BPM system uses five micro-stripline beam position monitors processed by log ratio processing electronics with data acquisition via a series of custom TMS32OC40 Digital Signal Processing (DSP) boards. Of special interest to this paper is the operation of the system, the log ratio processing, and the system calibration technique. This paper will also cover the DSP system operations and their interaction with the main accelerator control system.

  9. Active imaging for monitoring and technical diagnostics

    Directory of Open Access Journals (Sweden)

    Marek Piszczek

    2014-08-01

    Full Text Available The article presents the results of currently running work in the field of active imaging. The term active refers to both the image acquisition methods, so-called methods of the spatio-temporal framing and active visualization method applying augmented reality. Also results of application of the HMD and 6DoF modules as well as the experimental laser photography device are given. The device works by methods of spatio-temporal framing and it has been developed at the IOE WAT. In terms of image acquisition - active imaging involves the use of illumination of the observed scene. In the field of information visualization - active imaging directly concerns the issues of interaction human-machine environment. The results show the possibility of using the described techniques, among others, rescue (fire brigade, security of mass events (police or the protection of critical infrastructure as well as broadly understood diagnostic problems. Examples presented in the article show a wide range of possible uses of the methods both in observational techniques and measurement. They are relatively innovative solutions and require elaboration of series of hardware and algorithmic issues. However, already at this stage it is clear that active acquisition and visualization methods indicate a high potential for this type of information solutions.[b]Keywords[/b]: active imaging, augmented reality, digital image processing

  10. Mastitis diagnostics and performance monitoring: a practical approach

    NARCIS (Netherlands)

    Lam, T.J.G.M.; Olde Riekerink, R.; Sampimon, O.C.; Smith, H.E.

    2009-01-01

    In this paper a review is given of frequently used mastitis diagnostic methods in modern dairy practice. Methods used at the quarter, cow, herd and regional or national level are discussed, including their usability for performance monitoring in udder health. Future developments, such as systems in

  11. A vibroacoustic model of selected human larynx diseases.

    Science.gov (United States)

    Engel, Zbigniew Witold; Kłaczyński, Maciej; Wszołek, Wiesław

    2007-01-01

    With the present development of digital registration and methods for processing speech it is possible to make effective objective acoustic diagnostics for medical purposes. These methods are useful as all pathologies and diseases of the human vocal tract influence the quality of a patient's speech signal. Diagnostics of the voice organ can be defined as an unambiguous recognition of the current condition of a specific voice source. Such recognition is based on an evaluation of essential acoustic parameters of the speech signal. This requires creating a vibroacoustic model of selected deformations of Polish speech in relation to specific human larynx diseases. An analysis of speech and parameter mapping in 29-dimensional space is reviewed in this study. Speech parameters were extracted in time, frequency and cepstral (quefrency) domains resulting in diagrams that qualified symptoms and conditions of selected human larynx diseases. The paper presents graphically selected human larynx diseases.

  12. SOME PROBLEMS WITH VIBROACOUSTIC METHOD IN RELATION TO THE TRANSMISSION GEARBOX OF A MILITARY HELICOPTER

    Directory of Open Access Journals (Sweden)

    Paweł MAJEWSKI

    2016-12-01

    Full Text Available The article presents the results of a laboratory gear stage with regard to deepening its consumption. In addition, the study looked at the construction of the transmission gearbox of a military helicopter, according to the basic kinematic results of the analysis of vibroacoustic signals, in order to determine the diagnostic criteria for the assessment of the technical condition of a military helicopter’s transmission gearbox.

  13. The problem of carrying out a diagnosis of an internal combustion engine by vibroacoustical parameters

    Science.gov (United States)

    Lukanin, V. N.; Sidorov, V. I.

    1973-01-01

    The physics of noise formation in an internal combustion engine is discussed. A dependence of the acoustical radiation on the engine operating process, its construction, and operational parameters, as well as on the degree of wear on its parts, has been established. An example of tests conducted on an internal combustion engine is provided. A system for cybernetic diagnostics for internal combustion engines by vibroacoustical parameters is diagrammed.

  14. Neurological aspects of vibroacoustic disease.

    Science.gov (United States)

    Martinho Pimenta, A J; Castelo Branco, N A

    1999-03-01

    Mood and behavioral abnormalities are the most common early findings related to vibroacoustic disease (VAD). Other signs and symptoms have been observed in VAD patients. Brain MRI discloses small multifocal lesions in about 50% of subjects with more than 10 yr of occupational exposure to large pressure amplitude (> or = 90 dB SPL) and low frequency (< or = 500 Hz) (LPALF) noise. However, to date, there have been no studies globally integrating all the neurological, imaging and neurophysiological data of VAD patients. This is the main goal of this study. The 60 male Caucasians diagnosed with VAD were neurologically evaluated in extreme detail in order to systematically identify the most common and significant neurological disturbances in VAD. This population demonstrates cognitive changes (identified through psychological and neurophysiological studies (ERP P300)), vertigo and auditory changes, visual impairment, epilepsy, and cerebrovascular diseases. Neurological examination reveals pathological signs and reflexes, most commonly the palmo-mental reflex. A vascular pattern underlying the multifocal hyperintensities in T2 MR imaging, with predominant involvement of the small arteries of the white matter, is probably the visible organic substratum of the neurological picture. However, other pathophyisological mechanisms are involved in epileptic symptomatology.

  15. Advanced monitoring, fault diagnostics, and maintenance of cryogenic systems

    CERN Document Server

    Girone, Mario; Pezzetti, Marco

    In this Thesis, advanced methods and techniques of monitoring, fault diagnostics, and predictive maintenance for cryogenic processes and systems are described. In particular, in Chapter 1, mainstreams in research on measurement systems for cryogenic processes are reviewed with the aim of dening key current trends and possible future evolutions. Then, in Chapter 2, several innovative methods are proposed. A transducer based on a virtual ow meter is presented for monitoring helium distribution and consumption in cryogenic systems for particle accelerators [1]. Furthermore, a comprehensive metrological analysis of the proposed transducer for verifying the metrological performance and pointing out most critical uncertainty sources is described [2]. A model-based method for fault detection and early-stage isolation, able to work with few records of Frequency Response Function (FRF) on an unfaulty compressor, is then proposed [3]. To enrich the proposal, a distributed diagnostic procedure, based on a micro-genetic...

  16. Process Diagnostics and Monitoring Using the Multipole Resonance Probe (MRP)

    Science.gov (United States)

    Harhausen, J.; Awakowicz, P.; Brinkmann, R. P.; Foest, R.; Lapke, M.; Musch, T.; Mussenbrock, T.; Oberrath, J.; Ohl, A.; Rolfes, I.; Schulz, Ch.; Storch, R.; Styrnoll, T.

    2011-10-01

    In this contribution we present the application of the MRP in an industrial plasma ion assisted deposition (PIAD) chamber (Leybold optics SYRUS-pro). The MRP is a novel plasma diagnostic which is suitable for an industrial environment - which means that the proposed method is robust, calibration free, and economical, and can be used for ideal and reactive plasmas alike. In order to employ the MRP as process diagnostics we mounted the probe on a manipulator to obtain spatially resolved information on the electron density and temperature. As monitoring tool the MRP is installed at a fixed position. Even during the deposition process it provides stable measurement results while other diagnostic methods, e.g. the Langmuir probe, may suffer from dielectric coatings. In this contribution we present the application of the MRP in an industrial plasma ion assisted deposition (PIAD) chamber (Leybold optics SYRUS-pro). The MRP is a novel plasma diagnostic which is suitable for an industrial environment - which means that the proposed method is robust, calibration free, and economical, and can be used for ideal and reactive plasmas alike. In order to employ the MRP as process diagnostics we mounted the probe on a manipulator to obtain spatially resolved information on the electron density and temperature. As monitoring tool the MRP is installed at a fixed position. Even during the deposition process it provides stable measurement results while other diagnostic methods, e.g. the Langmuir probe, may suffer from dielectric coatings. Funded by the German Ministry for Education and Research (BMBF, Fkz. 13N10462).

  17. Saliva: a potential media for disease diagnostics and monitoring.

    Science.gov (United States)

    Liu, Jingyi; Duan, Yixiang

    2012-07-01

    Within the past 10 years, the use of saliva as a diagnostic tool has gained considerable attention and become a well-accepted method. As a diagnostic fluid, saliva offers superiority over serum due to both a noninvasive collection method by specially trained persons and a cost-effective approach for screening of large populations. Collection of saliva offers a reduced risk of infection compared to the collection of serum. Moreover, obtaining saliva samples from infant, disabled or anxious patients, is much easier than obtaining other samples. There is a lot of useful components-changing information in saliva when a person is in sick. Therefore, we define these changing components as "biomarkers". The utilization of biomarkers as early predictors for clinical disease not only contributes to the effective prevention and treatment of diseases, but also enhances the assessment of potential health risks. In this article, we have reviewed the properties of saliva, the salivary analysis method for biomarker discovery, and the diagnostic potentials of salivary biomarkers in monitoring and detecting periodontal disease, Oral and Breast cancers, and Sjögren's syndrome. We also discussed some barriers of applications of saliva as a diagnostic media as well as recent improvements. We also prospected the future processing directions of using biomarkers in disease diagnosis and draw a conclusion that saliva is indeed an effective media in various disease monitoring and diagnosis. Copyright © 2012 Elsevier Ltd. All rights reserved.

  18. Ares I-X Vibroacoustic Environments

    Science.gov (United States)

    Larsen, Curtis E.; Schuster, David M.; Kaufman, Daniel S.

    2009-01-01

    This paper provides a summary of the NASA Engineering and Safety Center (NESC) team recommendations and observations following participation with the Ares I-X Vibroacoustic (VA) Environments Panel in meetings at the Kennedy Space Center (KSC) and the Marshall Space Flight Center (MSFC) in March and April 2008, respectively.

  19. Selection of informative parameters of vibroacoustic processes

    Science.gov (United States)

    Koshek, L. N.

    1973-01-01

    The problem of selecting informative parameters of vibro-acoustic processes and the construction of apparatus for their determination are discussed. It is assumed that the processes being investigated are structurally uniform and either purely random or contain not very many determinative components.

  20. Nonlinear vibroacoustic wave modulations for structural damage detection: an overview

    Science.gov (United States)

    Pieczonka, Lukasz; Klepka, Andrzej; Martowicz, Adam; Staszewski, Wieslaw J.

    2016-01-01

    We present an overview of research developments related to the nonlinear vibroacoustic modulation technique used for structural damage detection. The method of interest is based on nonlinear interactions of a low-frequency pumping wave and a high-frequency probing wave. These two waves are introduced to monitored structures simultaneously. Then the presence of damage is exhibited by additional frequency components that result from nonlinear damage-wave interactions. A vast amount of research has been performed in this area over the last two decades. We aim to present the state-of-the-art of these developments. The major focus is on monitoring approaches, modeling aspects, actuation/sensing, signal processing, and application examples.

  1. Vibroacoustic sound therapy improves pain management and more.

    Science.gov (United States)

    Boyd-Brewer, Chris; McCaffrey, Ruth

    2004-01-01

    Vibroacoustic therapy is a new sound technology that uses audible sound vibrations to reduce symptoms, invoke relaxation, and alleviate stress. This technology is developed based on the recognition that external vibration can influence body function. Research demonstrates the effectiveness of vibroacoustic therapy. Implications for nurses include investigating the possibilities of vibroacoustic therapy in various nursing settings to promote patient well-being and improve the therapeutic environment.

  2. Noninvasive multianalyte diagnostic assay for monitoring bladder cancer recurrence

    Directory of Open Access Journals (Sweden)

    Shore ND

    2012-10-01

    Full Text Available Neal D Shore,1 Cecilia A Fernandez,2 Anthony P Shuber21Carolina Urologic Research Center/Atlantic Urology Clinics, Myrtle Beach, SC, 2Predictive Biosciences Inc, Lexington, MA, USABackground: The purpose of this study was to establish the clinical performance of a urine-based assay, called a multianalyte diagnostic readout, in monitoring for bladder cancer recurrence.Methods: This was a prospective, multicenter, single assessment observational study. The multianalyte diagnostic readout uses a combination of one protein and three DNA biomarkers. Urine samples from 733 patients undergoing monitoring for bladder cancer recurrence were analyzed for matrix metalloproteinase-2 levels, the presence of mutant FGFR3 DNA, and hypermethylation of the NID2 and VIM genes. The probability of a patient having (positive predictive value or not having (negative predictive value recurrent bladder cancer was determined by FGFR3 alone or all four biomarkers combined, respectively.Results: Cystoscopy/biopsy diagnosed 63 patients with bladder cancer recurrence at the time of study assessment. The four-biomarker assay identified 237 patients as having a low probability of disease recurrence, 231 of whom were determined by cystoscopy as not having recurrent cancer, resulting in a negative predictive value of 97.5% at 90.5% sensitivity. The FGFR3 assay identified 49 patients with FGFR3 mutations, 19 of whom were confirmed by biopsy as having cancer, resulting in a positive predictive value of 38.8%, with 95.5% specificity.Conclusion: The urine-based multianalyte diagnostic readout assay was able to delineate the patient population into those highly likely to have bladder cancer recurrence, those unlikely to have recurrent disease, and those with an average risk for bladder cancer recurrence.Keywords: FGFR3, matrix metalloproteinase-2, NID2, VIM, recurrent bladder cancer

  3. Vibro-acoustics of lightweight sandwich structures

    CERN Document Server

    Lu, Tianjian

    2014-01-01

    Vibro-Acoustics of Lightweight Sandwich Structures introduces the study of the coupled vibration and acoustic behavior of lightweight sandwich structures in response to harmonic force and sound pressure. This book focuses on the theoretical modeling and experimental investigation of lightweight sandwich structures in order to provide a predictive framework for vibro-acoustic characteristics of typical engineering structures. Furthermore, by developing solution tools, it concentrates on the influence of key systematic parameters leading to effective guidance for optimal structure design toward lightweight, high-stiffness and superior sound insulation capability. This book is intended for researchers, scientists, engineers and graduate students in mechanical engineering especially in structural mechanics, mechanics and acoustics. Fengxian Xin and Tianjian Lu both work at the School of Aerospace, Xi’an Jiaotong University.

  4. Very High Frequency Monitoring System for Engine Gearbox and Generator Health Management (Postprint)

    National Research Council Canada - National Science Library

    Watson, Matthew J; Byington, Carl S; Behbahani, Alireza

    2007-01-01

    ...) vibration monitoring system that integrates various vibro-acoustic data with intelligent feature extraction and fault isolation algorithms to effectively assess engine gearbox and generator health...

  5. CONCEPTION OF USE VIBROACOUSTIC SIGNALS AND NEURAL NETWORKS FOR DIAGNOSING OF CHOSEN ELEMENTS OF INTERNAL COMBUSTION ENGINES IN CAR VEHICLES

    Directory of Open Access Journals (Sweden)

    Piotr CZECH

    2014-03-01

    Full Text Available Currently used diagnostics systems are not always efficient and do not give straightforward results which allow for the assessment of the technological condition of the engine or for the identification of the possible damages in their early stages of development. Growing requirements concerning durability, reliability, reduction of costs to minimum and decrease of negative influence on the natural environment are the reasons why there is a need to acquire information about the technological condition of each of the elements of a vehicle during its exploitation. One of the possibilities to achieve information about technological condition of a vehicle are vibroacoustic phenomena. Symptoms of defects, achieved as a result of advanced methods of vibroacoustic signals processing can serve as models which can be used during construction of intelligent diagnostic system based on artificial neural networks. The work presents conception of use artificial neural networks in the task of combustion engines diagnosis.

  6. Smart Structures and Intelligent Systems for Health Monitoring and Diagnostics

    Directory of Open Access Journals (Sweden)

    M. A. El-Sherif

    2005-01-01

    Full Text Available “Smart and intelligent” structures are defined as structures capable of monitoring their own “health” condition and structural behavior, such structures are capable of sensing external environmental conditions, making decisions, and sending the information to other locations. Available conventional devices and systems are not technologically mature for such applications. New classes of miniature devices and networking systems are urgently needed for such applications. In this paper, two examples of the successful work achieved so far, in biomedical application of smart structures, are presented. The first one is based on the development of a smart bone fixation device for rehabilitation and treatment. This device includes a smart composite bar that can sense physical stress applied to the fractured bones, and send the information to the patient's physician remotely. The second is on the development of smart fabrics for many applications including health monitoring and diagnostics. Successful development of such smart fabrics with embedded fiber optic sensors and networks is mainly dependent on the development of the proper miniature sensor technology, and on the integration of these sensors into textile structures. The developed smart structures will be discussed and samples of the results will be presented.

  7. Diagnostics monitor of the braking efficiency in the on board diagnostics system for the motor vehicles

    Science.gov (United States)

    Gajek, Andrzej

    2016-09-01

    The article presents diagnostics monitor for control of the efficiency of brakes in various road conditions in cars equipped with pressure sensor in brake (ESP) system. Now the brake efficiency of the vehicles is estimated periodically in the stand conditions on the base of brake forces measurement or in the road conditions on the base of the brake deceleration. The presented method allows to complete the stand - periodical tests of the brakes by current on board diagnostics system OBD for brakes. First part of the article presents theoretical dependences between deceleration of the vehicle and brake pressure. The influence of the vehicle mass, initial speed of braking, temperature of brakes, aerodynamic drag, rolling resistance, engine resistance, state of the road surface, angle of the road sloping on the deceleration have been analysed. The manner of the appointed of these parameters has been analysed. The results of the initial investigation have been presented. At the end of the article the strategy of the estimation and signalization of the irregular value of the deceleration are presented.

  8. Shuttle payload vibroacoustic test plan evaluation

    Science.gov (United States)

    Stahle, C. V.; Gongloff, H. R.; Young, J. P.; Keegan, W. B.

    1977-01-01

    Statistical decision theory is used to evaluate seven alternate vibro-acoustic test plans for Space Shuttle payloads; test plans include component, subassembly and payload testing and combinations of component and assembly testing. The optimum test levels and the expected cost are determined for each test plan. By including all of the direct cost associated with each test plan and the probabilistic costs due to ground test and flight failures, the test plans which minimize project cost are determined. The lowest cost approach eliminates component testing and maintains flight vibration reliability by performing subassembly tests at a relatively high acoustic level.

  9. Social network diagnostics: a tool for monitoring group interventions.

    Science.gov (United States)

    Gesell, Sabina B; Barkin, Shari L; Valente, Thomas W

    2013-10-01

    Many behavioral interventions designed to improve health outcomes are delivered in group settings. To date, however, group interventions have not been evaluated to determine if the groups generate interaction among members and how changes in group interaction may affect program outcomes at the individual or group level. This article presents a model and practical tool for monitoring how social ties and social structure are changing within the group during program implementation. The approach is based on social network analysis and has two phases: collecting network measurements at strategic intervention points to determine if group dynamics are evolving in ways anticipated by the intervention, and providing the results back to the group leader to guide implementation next steps. This process aims to initially increase network connectivity and ultimately accelerate the diffusion of desirable behaviors through the new network. This article presents the Social Network Diagnostic Tool and, as proof of concept, pilot data collected during the formative phase of a childhood obesity intervention. The number of reported advice partners and discussion partners increased during program implementation. Density, the number of ties among people in the network expressed as a percentage of all possible ties, increased from 0.082 to 0.182 (p 0.05) in the discussion network. The observed two-fold increase in network density represents a significant shift in advice partners over the intervention period. Using the Social Network Tool to empirically guide program activities of an obesity intervention was feasible.

  10. Vibroacoustic stimulation in normal term human pregnancy.

    Science.gov (United States)

    D'Elia, A; Pighetti, M; Vanacore, F; Fabbrocini, G; Arpaia, L

    2005-05-01

    To examine the effects of vibroacoustic stimulation (VAS) on fetal heart rate (FHR) in term human fetuses by computerized carditocography system. FHR was analyzed 20 min before and 30 min after vibroacoustic stimulation using the Oxford Sonicaid System 8002 for computerized FHR measurement. Recordings were made in 31 uncomplicated pregnancies at 36-42 weeks' gestation. Vibroacustic stimulation of the fetus evoked a significant increase in all the parameters evaluated (number of fetal movements, of accelerations above 10 and 15 bpm, in high- and low-variability episodes, and in short-term variations). Concerning the effect of behavioural states on the response to VAS, some changes (FHR, high-variability episodes) occurred independently of behavioural states, while other parameters (accelerations >10 and 15 bpm: short-term variation) underwent statistically significant changes only for behavioural states 1F and 2F. Our study supports the hypothesis of a significant fetal response in normal term pregnancy, as clearly shown by computerized cardiotocography. The immediate response occurred independently of behavioural states, although some differences were present (mainly for F1 and F2 states) if the evaluation was extended in time.

  11. Vibro-acoustic Imaging at the Breazeale Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Smith, James Arthur [Idaho National Lab. (INL), Idaho Falls, ID (United States); Jewell, James Keith [Idaho National Lab. (INL), Idaho Falls, ID (United States); Lee, James Edwin [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-09-01

    The INL is developing Vibro-acoustic imaging technology to characterize microstructure in fuels and materials in spent fuel pools and within reactor vessels. A vibro-acoustic development laboratory has been established at the INL. The progress in developing the vibro-acoustic technology at the INL is the focus of this report. A successful technology demonstration was performed in a working TRIGA research reactor. Vibro-acoustic imaging was performed in the reactor pool of the Breazeale reactor in late September of 2015. A confocal transducer driven at a nominal 3 MHz was used to collect the 60 kHz differential beat frequency induced in a spent TRIGA fuel rod and empty gamma tube located in the main reactor water pool. Data was collected and analyzed with the INLDAS data acquisition software using a short time Fourier transform.

  12. Fetal vibroacoustic stimulation for facilitation of tests of fetal wellbeing.

    Science.gov (United States)

    Tan, Kelvin H; Smyth, Rebecca M D; Wei, Xing

    2013-12-07

    Acoustic stimulation of the fetus has been suggested to improve the efficiency of antepartum fetal heart rate testing. To assess the advantages and disadvantages of the use of fetal vibroacoustic stimulation in conjunction with tests of fetal wellbeing. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 September 2013). All published and unpublished randomised controlled trials assessing the merits of the use of fetal vibroacoustic stimulation in conjunction with tests of fetal wellbeing. All review authors independently extracted data and assessed trial quality. Authors of published and unpublished trials were contacted for further information. Altogether 12 trials with a total of 6822 participants were included. Fetal vibroacoustic stimulation reduced the incidence of non-reactive antenatal cardiotocography test (nine trials; average risk ratio (RR) 0.62, 95% confidence interval (CI) 0.48 to 0.81). Vibroacoustic stimulation compared with mock stimulation evoked significantly more fetal movements when used in conjunction with fetal heart rate testing (one trial, RR 0.23, 95% CI 0.18 to 0.29). Vibroacoustic stimulation offers benefits by decreasing the incidence of non-reactive cardiotocography and reducing the testing time. Further randomised trials should be encouraged to determine not only the optimum intensity, frequency, duration and position of the vibroacoustic stimulation, but also to evaluate the efficacy, predictive reliability, safety and perinatal outcome of these stimuli with cardiotocography and other tests of fetal wellbeing.

  13. Low-cost fiber Bragg grating vibroacoustic sensor for voice and heartbeat detection.

    Science.gov (United States)

    Tosi, Daniele; Olivero, Massimo; Perrone, Guido

    2008-10-01

    A fiber Bragg grating (FBG) vibroacoustic sensor exploiting an intensity-based interrogation principle is presented. The optical system is complemented by signal processing techniques that allow disturbances to be mitigated and improve the spectral estimation. The sensor is capable of performing frequency analysis of sounds up to 3 kHz, with top sensitivity in the 100-500 Hz frequency range, and of dynamically tracking pulsed phenomena that induce a strain to the FBG. The sensor has been applied to the detection of voice, showing a great intelligibility of the speech despite the low-quality environment, and to the monitoring of the heartbeat rate from the wrist.

  14. NuSTAR: Vibro-Acoustic Tests

    Energy Technology Data Exchange (ETDEWEB)

    Kasim, K.

    2004-09-03

    NuSTAR is a satellite that will be carrying X-ray optics that consist of many nested glass cylinders. Due to different acoustic environments, the glass may react such that cracks and/or fractures may form. Cracks and/or fractures in the glass would not allow the optic to work properly. Therefore, it is necessary to test the glass and optic prototypes to determine if they will be able to withhold when experiencing certain acoustic environments. The vibro-acoustic testing conducted at the Jet Propulsion Laboratory (JPL) in Pasadena determined that under the minimum workmanship acoustic environments, the glass on the optics will not fail. Overall, the results of the test were successful which gives confidence that when the satellite is launched into the air and then dropped into space, the glass in the optics will not fail.

  15. Aero and vibroacoustics of automotive turbochargers

    CERN Document Server

    Nguyen-Schäfer, Hung

    2013-01-01

    Aero and Vibroacoustics of Automotive Turbochargers is a topic involving aspects from the working fields of thermodynamics of turbomachinery, aerodynamics, rotordynamics, and noise propagation computation.   In this broadly interdisciplinary subject, thermodynamics of turbomachinery is used to design the turbocharger and to determine its operating conditions.  Aerodynamics is needed to study the compressor flow dynamics and flow instabilities of rotating stall and surge, which can produce growling and whining-type noises. Rotordynamics is necessary to study rotor unbalance and self-excited oil-whirl instabilities, which lead to whistling and constant tone-type noises in rotating floating oil-film type bearings. For the special case of turbochargers using ball bearings, some high-order harmonic and wear noises also manifest in the rotor operating range. Lastly, noise propagation computation, based on Lighthill’s analogy, is required to investigate airborne noises produced by turbochargers in passenger vehi...

  16. Fetal heart rate after vibroacoustic stimulation.

    Science.gov (United States)

    Hoh, Jeong Kyu; Park, Young-Sun; Cha, Kyung-Joon; Park, Moon-Il

    2009-07-01

    To define reference ranges for fetal heart rate (FHR) parameters after vibroacoustic stimulation (VAS) according to gestational age by determining the relationship between FHR and gestational age using a computerized analysis system. Data were analyzed from 3453 women using 10-minute observational recordings during nonstress testing (NST) and VAS testing. FHR parameters were analyzed according to gestational age. All FHR parameters were related to gestational age except for mean baseline FHR, which did not vary significantly with gestational age. All other parameters followed trends similar to the NST results, except for decelerations. FHR parameters after VAS differed significantly according to gestational age. The results suggest that the gestational age of the fetus should be considered when interpreting FHR patterns after VAS.

  17. Shuttle payload minimum cost vibroacoustic tests

    Science.gov (United States)

    Stahle, C. V.; Gongloff, H. R.; Young, J. P.; Keegan, W. B.

    1977-01-01

    This paper is directed toward the development of the methodology needed to evaluate cost effective vibroacoustic test plans for Shuttle Spacelab payloads. Statistical decision theory is used to quantitatively evaluate seven alternate test plans by deriving optimum test levels and the expected cost for each multiple mission payload considered. The results indicate that minimum costs can vary by as much as $6 million for the various test plans. The lowest cost approach eliminates component testing and maintains flight vibration reliability by performing subassembly tests at a relatively high acoustic level. Test plans using system testing or combinations of component and assembly level testing are attractive alternatives. Component testing alone is shown not to be cost effective.

  18. Quantitative optical diagnostics in pathology recognition and monitoring of tissue reaction to PDT

    Science.gov (United States)

    Kirillin, Mikhail; Shakhova, Maria; Meller, Alina; Sapunov, Dmitry; Agrba, Pavel; Khilov, Alexander; Pasukhin, Mikhail; Kondratieva, Olga; Chikalova, Ksenia; Motovilova, Tatiana; Sergeeva, Ekaterina; Turchin, Ilya; Shakhova, Natalia

    2017-07-01

    Optical coherence tomography (OCT) is currently actively introduced into clinical practice. Besides diagnostics, it can be efficiently employed for treatment monitoring allowing for timely correction of the treatment procedure. In monitoring of photodynamic therapy (PDT) traditionally employed fluorescence imaging (FI) can benefit from complementary use of OCT. Additional diagnostic efficiency can be derived from numerical processing of optical diagnostics data providing more information compared to visual evaluation. In this paper we report on application of OCT together with numerical processing for clinical diagnostic in gynecology and otolaryngology, for monitoring of PDT in otolaryngology and on OCT and FI applications in clinical and aesthetic dermatology. Image numerical processing and quantification provides increase in diagnostic accuracy. Keywords: optical coherence tomography, fluorescence imaging, photod

  19. Improving Inspection and Maintenance Performance and On-board Diagnostics Monitor Readiness Memo

    Science.gov (United States)

    This EPA memorandum transmits an updated list of vehicles that exhibit issues related to OBD (on board diagnostics) monitor readiness and makes suggestions for how Inspection/Maintenance (I/M) programs can improve operational performance by addressing

  20. Growth monitoring and diagnostic work-up of short stature: An International Inventorization

    NARCIS (Netherlands)

    Grote, F.K.; Oostdijk, W.; Muinck Keizer-Schrama, S.M.P.F. de; Dekker, F.W.; Verkerk, P.H.; Wit, J.M.

    2005-01-01

    Background/Aims: Growth monitoring is almost universally performed, but few data are available on which referral criteria and diagnostic work-up are used worldwide for children with short stature. Methods: A short questionnaire, containing questions on auxological screening and on diagnostic

  1. The Galileo PPS expert monitoring and diagnostic prototype

    Science.gov (United States)

    Bahrami, Khosrow

    1989-01-01

    The Galileo PPS Expert Monitoring Module (EMM) is a prototype system implemented on the SUN workstation that will demonstrate a knowledge-based approach to monitoring and diagnosis for the Galileo spacecraft Power/Pyro subsystems. The prototype will simulate an analysis module functioning within the SFOC Engineering Analysis Subsystem Environment (EASE). This document describes the implementation of a prototype EMM for the Galileo spacecraft Power Pyro Subsystem. Section 2 of this document provides an overview of the issues in monitoring and diagnosis and comparison between traditional and knowledge-based solutions to this problem. Section 3 describes various tradeoffs which must be considered when designing a knowledge-based approach to monitoring and diagnosis, and section 4 discusses how these issues were resolved in constructing the prototype. Section 5 presents conclusions and recommendations for constructing a full-scale demonstration of the EMM. A Glossary provides definitions of terms used in this text.

  2. Energy Harvesting with Piezoelectric Element Using Vibroacoustic Coupling Phenomenon

    Directory of Open Access Journals (Sweden)

    Hiroyuki Moriyama

    2013-01-01

    Full Text Available This paper describes the vibroacoustic coupling between the structural vibrations and internal sound fields of thin structures. In this study, a cylindrical structure with thin end plates is subjected to the harmonic point force at one end plate or both end plates, and a natural frequency of the end plates is selected as the forcing frequency. The resulting vibroacoustic coupling is then analyzed theoretically and experimentally by considering the dynamic behavior of the plates and the acoustic characteristics of the internal sound field as a function of the cylinder length. The length and phase difference between the plate vibrations, which maximize the sound pressure level inside the cavity, are clarified theoretically. The theoretical results are validated experimentally through an excitation experiment using an experimental apparatus that emulates the analytical model. Moreover, the electricity generation experiment verifies that sufficient vibroacoustic coupling can be created for the adopted electricity generating system to be effective as an electric energy-harvesting device.

  3. Mobile point-of-care monitors and diagnostic device design

    CERN Document Server

    Karlen, Walter

    2014-01-01

    PrefaceEditorsContributorsSensors and SystemsInterfacing Diagnostics with Consumer ElectronicsPakorn Preechaburana, Anke Suska, and Daniel FilippiniLab on a CellphoneAhmet F. Coskun, Hongying Zhu, Onur Mudanyali, and Aydogan OzcanThe Phone OximeterChristian Leth PetersenCurrent Technology and Advances in Transepidermal Water Loss SensorsPietro Salvo, Bernardo Melai, Nicola Calisi, and Fabio Di FrancescoPortable High-Frequency Ultrasound Imaging System Design and Hardware Considerations

  4. Vibration-based monitoring and diagnostics using compressive sensing

    Science.gov (United States)

    Ganesan, Vaahini; Das, Tuhin; Rahnavard, Nazanin; Kauffman, Jeffrey L.

    2017-04-01

    Vibration data from mechanical systems carry important information that is useful for characterization and diagnosis. Standard approaches rely on continually streaming data at a fixed sampling frequency. For applications involving continuous monitoring, such as Structural Health Monitoring (SHM), such approaches result in high volume data and rely on sensors being powered for prolonged durations. Furthermore, for spatial resolution, structures are instrumented with a large array of sensors. This paper shows that both volume of data and number of sensors can be reduced significantly by applying Compressive Sensing (CS) in vibration monitoring applications. The reduction is achieved by using random sampling and capitalizing on the sparsity of vibration signals in the frequency domain. Preliminary experimental results validating CS-based frequency recovery are also provided. By exploiting the sparsity of mode shapes, CS can also enable efficient spatial reconstruction using fewer spatially distributed sensors. CS can thereby reduce the cost and power requirement of sensing as well as streamline data storage and processing in monitoring applications. In well-instrumented structures, CS can enable continued monitoring in case of sensor or computational failures.

  5. Saliva-Based Biosensors: Noninvasive Monitoring Tool for Clinical Diagnostics

    Directory of Open Access Journals (Sweden)

    Radha S. P. Malon

    2014-01-01

    Full Text Available Saliva is increasingly recognised as an attractive diagnostic fluid. The presence of various disease signalling salivary biomarkers that accurately reflect normal and disease states in humans and the sampling benefits compared to blood sampling are some of the reasons for this recognition. This explains the burgeoning research field in assay developments and technological advancements for the detection of various salivary biomarkers to improve clinical diagnosis, management, and treatment. This paper reviews the significance of salivary biomarkers for clinical diagnosis and therapeutic applications, with focus on the technologies and biosensing platforms that have been reported for screening these biomarkers.

  6. Saliva-based biosensors: noninvasive monitoring tool for clinical diagnostics.

    Science.gov (United States)

    Malon, Radha S P; Sadir, Sahba; Balakrishnan, Malarvili; Córcoles, Emma P

    2014-01-01

    Saliva is increasingly recognised as an attractive diagnostic fluid. The presence of various disease signalling salivary biomarkers that accurately reflect normal and disease states in humans and the sampling benefits compared to blood sampling are some of the reasons for this recognition. This explains the burgeoning research field in assay developments and technological advancements for the detection of various salivary biomarkers to improve clinical diagnosis, management, and treatment. This paper reviews the significance of salivary biomarkers for clinical diagnosis and therapeutic applications, with focus on the technologies and biosensing platforms that have been reported for screening these biomarkers.

  7. Vibroacoustic test plan evaluation: Parameter variation study

    Science.gov (United States)

    Stahle, C. V.; Gongloef, H. R.

    1976-01-01

    Statistical decision models are shown to provide a viable method of evaluating the cost effectiveness of alternate vibroacoustic test plans and the associated test levels. The methodology developed provides a major step toward the development of a realistic tool to quantitatively tailor test programs to specific payloads. Testing is considered at the no test, component, subassembly, or system level of assembly. Component redundancy and partial loss of flight data are considered. Most and probabilistic costs are considered, and incipient failures resulting from ground tests are treated. Optimums defining both component and assembly test levels are indicated for the modified test plans considered. modeling simplifications must be considered in interpreting the results relative to a particular payload. New parameters introduced were a no test option, flight by flight failure probabilities, and a cost to design components for higher vibration requirements. Parameters varied were the shuttle payload bay internal acoustic environment, the STS launch cost, the component retest/repair cost, and the amount of redundancy in the housekeeping section of the payload reliability model.

  8. The effects of maternal depression on fetal heart rate response to vibroacoustic stimulation.

    Science.gov (United States)

    Allister, L; Lester, B M; Carr, S; Liu, J

    2001-01-01

    To better understand the effects of untreated maternal depression on the fetus, this study examined fetal heart rate (FHR) and FHR reactivity to vibroacoustic stimulation in pregnant women with untreated depression. The 20 participants were 32- to 36-week pregnant women divided into groups with depression (N = 10) and without depression (N = 10) based on the Beck Depression Inventory (BDI; Beck, 1977; Beck & Steer, 1987). Participants were attached to a fetal heart monitor, and 10 min of baseline FHR were recorded. A vibroacoustic stimulus (VAS) was presented, and an additional 10 min of FHR were recorded. Fetuses of mothers with depression had an elevated baseline FHR and a 3.5-fold delay in return to baseline FHR after VAS presentation. Additionally, mothers with depression had significantly higher anxiety levels and took fewer prenatal vitamins during pregnancy. Delayed habituation of FHR in the fetuses of mothers with depression may be due to alterations in the internal hormonal environment and could have implications for postnatal information processing.

  9. TRTViewer: the ATLAS TRT detector monitoring and diagnostics tool

    CERN Document Server

    Smirnov, S.Yu.

    2013-01-01

    The Transition Radiation Tracker (TRT) is the outermost of the three sub-systems of the ATLAS Inner Detector at the LargeHadron Collider (LHC) at CERN. It is designed to combine the drift tube tracker with transition radiation detector, providing an important contribution to the charged particles precise momentum measurement and particle (mainly electron) identification. The TRT consists of a barrel section at small pseudo rapidity (eta) and two separate end-cap partitions at large eta. The detector performance and its operational conditions were permanently monitored during all commissioning and data-taking stages using various software tools, one of which -- TRTViewer -- is described in the present paper. The TRTViewer is the dedicated program for monitoring the TRT raw data quality and detector performance at different hardware levels: individual straws, readout chips and electronic boards. The data analysis results can be presented on the event-by-event basis or in the form of color maps representing the ...

  10. Apparatus and method for monitoring breath acetone and diabetic diagnostics

    Science.gov (United States)

    Duan, Yixiang [Los Alamos, NM; Cao, Wenqing [Los Alamos, NM

    2008-08-26

    An apparatus and method for monitoring diabetes through breath acetone detection and quantitation employs a microplasma source in combination with a spectrometer. The microplasma source provides sufficient energy to produce excited acetone fragments from the breath gas that emit light. The emitted light is sent to the spectrometer, which generates an emission spectrum that is used to detect and quantify acetone in the breath gas.

  11. TRTViewer: the ATLAS TRT detector monitoring and diagnostics tool.

    CERN Document Server

    Smirnov, S Yu; The ATLAS collaboration

    2011-01-01

    The Transition Radiation Tracker (TRT) is the outermost of the three sub-systems of the ATLAS Inner Detector at the Large Hadron Collider (LHC) at CERN. It consists of close to 300000 thin-walled drift tubes (straws), providing on average 30 two-dimensional space points with 130 um resolution for charged particle tracks. Along with continuous tracking, it provides particle identification capability through the detection of transition radiation X-ray photons generated by high velocity particles in the many polymer fibers or films that fill the spaces between the straws, thus enabling the detector to separate electrons from pions over the energy range between 1 and 200 GeV. The TRT performance and its operation conditions have been permanently monitored during all commissioning and data-taking periods using various software tools, one of which - TRTViewer - is described in the present paper. The TRTViewer is the dedicated program for monitoring the TRT raw data quality and detector performance at different hard...

  12. Diagnostic Capacity of Central Hemodynamic Monitoring at Thoracic Cancer Surgery

    Directory of Open Access Journals (Sweden)

    A. M. Batyrshina

    2011-01-01

    Full Text Available Objective: to study hemodynamic changes and the development rate of adaptive reactions in patients with hypokinetic circulation during lung resections varying in volumes. Subjects and methods. Thirty-eight patients with hypo-kinetic circulation, who had undergone sublobar resections, lobectomies, and pneumonectomies, were examined. The values of hemodynamics and gas exchange were recorded at the basic surgical stages and in the early postoperative period (on days 1, 3, 7, and 10. Results. When the patient is placed in the lateral position, the lung is switched off, or the surgical pneumothorax is less than 10—12%, cardiac index changes generally fail to give rise to the decompensation of adaptive processes in the cardiovascular system if the volume of a surgical intervention does not exceed that of sublobar resections or lobectomies. A 15% or more change in cardiac index during controlled lung collapse even with the minimum volume of surgery is indicative of the breakdown of physiological adaptation processes and may manifest itself through the symptoms of cardiorespiratory decompensation in both intra- and postoperative periods. Conclusion. The patients with baseline poor, hypokinetic circulation need not only adequate preoperative estimation of central hemodynamic values, but also continuous intraoperative monitoring of the basic parameters of central hemodynamics. The magnitude of a reduction in cardiac index is prognostically important at the stage of one-lung ventilation during surgical pneumothorax. Key words: hypokinetic circulation, thoracic cancer surgery, central hemodynamic monitoring.

  13. Vibroacoustic Model Validation for a Curved Honeycomb Composite Panel

    Science.gov (United States)

    Buehrle, Ralph D.; Robinson, Jay H.; Grosveld, Ferdinand W.

    2001-01-01

    Finite element and boundary element models are developed to investigate the vibroacoustic response of a curved honeycomb composite sidewall panel. Results from vibroacoustic tests conducted in the NASA Langley Structural Acoustic Loads and Transmission facility are used to validate the numerical predictions. The sidewall panel is constructed from a flexible honeycomb core sandwiched between carbon fiber reinforced composite laminate face sheets. This type of construction is being used in the development of an all-composite aircraft fuselage. In contrast to conventional rib-stiffened aircraft fuselage structures, the composite panel has nominally uniform thickness resulting in a uniform distribution of mass and stiffness. Due to differences in the mass and stiffness distribution, the noise transmission mechanisms for the composite panel are expected to be substantially different from those of a conventional rib-stiffened structure. The development of accurate vibroacoustic models will aide in the understanding of the dominant noise transmission mechanisms and enable optimization studies to be performed that will determine the most beneficial noise control treatments. Finite element and boundary element models of the sidewall panel are described. Vibroacoustic response predictions are presented for forced vibration input and the results are compared with experimental data.

  14. Vibro-acoustics of porous materials - waveguide modeling approach

    DEFF Research Database (Denmark)

    Darula, Radoslav; Sorokin, Sergey V.

    2016-01-01

    The porous material is considered as a compound multi-layered waveguide (i.e. a fluid layer surrounded with elastic layers) with traction free boundary conditions. The attenuation of the vibro-acoustic waves in such a material is assessed. This approach is compared with a conventional Biot's model...

  15. Monitoring and Diagnostics for C/C++ Real-Time Applications

    CERN Document Server

    Fischer, Yves

    Knowledge about the internal state of computational processes is essential for problem diagnostics as well as for constant monitoring and pre-failure recognition. The CMX li- brary provides monitoring capabilities similiar to the Java Management Extensions (JMX) for C and C++ applications. This thesis provides a detailed analysis of the requirements for monitoring and diagnos- tics of the C/C++ processes at CERN. The developed CMX library enables real-time C/C++ processes to expose values with- out harming their normal execution. CMX is portable and can be integrated in different monitoring architectures.

  16. Non-linear multimodal imaging for disease diagnostics and treatment monitoring

    Science.gov (United States)

    Bocklitz, Thomas; Schmitt, Michael; Lukić, Aleksandar; Heuke, Sandro; Chernavskaia, Olga; Meyer, Tobias; Popp, Jürgen

    2017-04-01

    Molecular imaging modalities, like multimodal imaging, e.g. the combination of coherent-anti-Stokes Raman scattering (CARS), second-harmonic generation (SHG) and two-photon-excited fluorescence (TPEF), feature a unique potential for disease diagnostics and treatment monitoring. In order to use the full potential of multi-modal imaging for diagnostic tasks powerful image analysis methods are necessary, which translate the physical measurements into medical meaningful information. This translation process requires standardization, correction procedures and statistical models like regression or classification models. With the help of these techniques medical relevant information can be extracted and used for the diagnostics of cancer or inflammation related diseases.

  17. 4th International Conference on Condition Monitoring of Machinery in Non-Stationary Operations

    CERN Document Server

    Zimroz, Radoslaw; Bartelmus, Walter; Haddar, Mohamed

    2016-01-01

    The book provides readers with a snapshot of recent research and technological trends in the field of condition monitoring of machinery working under a broad range of operating conditions. Each chapter, accepted after a rigorous peer-review process, reports on an original piece of work presented and discussed at the 4th International Conference on Condition Monitoring of Machinery in Non-stationary Operations, CMMNO 2014, held on December 15-16, 2014, in Lyon, France. The contributions have been grouped into three different sections according to the main subfield (signal processing, data mining, or condition monitoring techniques) they are related to. The book includes both theoretical developments as well as a number of industrial case studies, in different areas including, but not limited to: noise and vibration; vibro-acoustic diagnosis; signal processing techniques; diagnostic data analysis; instantaneous speed identification; monitoring and diagnostic systems; and dynamic and fault modeling. This book no...

  18. Velocity measurement by vibro-acoustic Doppler.

    Science.gov (United States)

    Nabavizadeh, Alireza; Urban, Matthew W; Kinnick, Randall R; Fatemi, Mostafa

    2012-04-01

    We describe the theoretical principles of a new Doppler method, which uses the acoustic response of a moving object to a highly localized dynamic radiation force of the ultrasound field to calculate the velocity of the moving object according to Doppler frequency shift. This method, named vibro-acoustic Doppler (VAD), employs two ultrasound beams separated by a slight frequency difference, Δf, transmitting in an X-focal configuration. Both ultrasound beams experience a frequency shift because of the moving objects and their interaction at the joint focal zone produces an acoustic frequency shift occurring around the low-frequency (Δf) acoustic emission signal. The acoustic emission field resulting from the vibration of the moving object is detected and used to calculate its velocity. We report the formula that describes the relation between Doppler frequency shift of the emitted acoustic field and the velocity of the moving object. To verify the theory, we used a string phantom. We also tested our method by measuring fluid velocity in a tube. The results show that the error calculated for both string and fluid velocities is less than 9.1%. Our theory shows that in the worst case, the error is 0.54% for a 25° angle variation for the VAD method compared with an error of -82.6% for a 25° angle variation for a conventional continuous wave Doppler method. An advantage of this method is that, unlike conventional Doppler, it is not sensitive to angles between the ultrasound beams and direction of motion.

  19. Performance testing of diesel engines using vibrational-acoustical diagnostic methods

    Energy Technology Data Exchange (ETDEWEB)

    Maack, H.H.; Neumann, G.

    1982-01-01

    Vibroacoustic condition monitoring is based on the measurement, processing and analysis of the solid-borne and airborne vibration signals emanating from a machine. Several assemblies belonging to diesel engines have a characteristic signal structure induced by impact excitation. The author proceeds from a generalised condition monitoring process to discuss the problem of the origin, transmission, measurement and analysis of vibroacoustic signals from diesel engines and presents a procedure based on a combination of frequency analysis in the temporary elimination of signal components.

  20. Filaria control and elimination: diagnostic, monitoring and surveillance needs.

    Science.gov (United States)

    Molyneux, David H

    2009-04-01

    Gold standard diagnosis using blood films or skin snips has dimished relevance as mass drug distribution programmes for control of filaria infections expand. The view of 'diagnosis' and its relevance at the individual level has changed, as it has been recognised that the spectrum of programmatic processes (mapping, mass drug interventions, monitoring and evaluation, and surveillance) require different approaches as different questions are asked at each stage. The feasibility and relevance of skin biopsy or blood film examination is challenged when mass drug distribution seeks to treat all eligibles in communities. The need to expand programmes rapidly by identifying the highest risk communities has seen the development of rapid assessment methods, such as rapid epidemiological mapping of onchocerciasis (REMO) and rapid epidemiological assessment (REA) for onchocerciasis, immunochromatographic test (ICT)-based mapping for lymphatic filariasis (LF), and Rapid Assessment Procedure for Loiasis (RAPLOA) for Loa, to reduce the risk of serious adverse events and to guide projects in high-risk communities. As programmes reduce the prevalence through mass drug distribution, more sensitive techniques are required to define endpoints, for LF in particular where the programmatic goal is elimination; for onchocerciasis, sensitive surveillance tools are required particularly in those areas where such risks of recrudescence are high. Whilst much progress has been made in the development and deployment of rapid methods, there are still specific needs for antigen detection in onchocerciasis, whilst standardisation of a panel of tools for LF will allow the definition of endpoint parameters so that countries can decide when mass drug administration (MDA) can be stopped and have a sensitive post-MDA surveillance system.

  1. Mechatronics in monitoring, simulation, and diagnostics of industrial and biological processes

    Science.gov (United States)

    Golnik, Natalia; Dobosz, Marek; Jakubowska, Małgorzata; Kościelny, Jan M.; Kujawińska, Małgorzata; Pałko, Tadeusz; Putz, Barbara; Sitnik, Robert; Wnuk, Paweł; Woźniak, Adam

    2013-10-01

    The paper describes a number of research projects of the Faculty of Mechatronics of Warsaw University of Technology in order to illustrate the use of common mechatronics and optomechatronics approach in solving multidisciplinary technical problems. Projects on sensors development, measurement and industrial control systems, multimodal data capture and advance systems for monitoring and diagnostics of industrial processes are presented and discussed.

  2. System for vibroacoustic inspection of equipment in the first loop of an atomic electric power plant. [PWR

    Energy Technology Data Exchange (ETDEWEB)

    Samarin, A.A.; Krasyuk, V.Ya.; Ivanov, Yu.S.; Pospelko, A.A.

    1975-11-01

    A system is described for vibroacoustic inspection of equipment in the first loop of a nuclear power plant with water-moderated water-cooled power reactors. This monitoring system is now in operation at the Novovoronezh Power Plant. The installation performs the following functions: measurement and registration of effective and peak levels of structural noise and vibrations of the main technological equipment in the first loop; amplitude-frequency analysis of structural noises and vibration of equipment; (sound and light) signaling when the current noise level and vibration level exceed the present level; provides facilities for an operator to listen to structural noise of running equipment.

  3. Abnormal respiratory drive in vibroacoustic disease.

    Science.gov (United States)

    Ferreira, João Reis; Albuquerque e Sousa, José; Foreld, Peter; Antunes, Marco; Cardoso, Sofia; Alves-Pereira, Mariana; Castelo Branco, Nuno A A

    2006-01-01

    Central nervous system disorders in workers exposed to low frequency noise (LFN, vibroacoustic disease (VAD) is defined as the systemic pathology caused by excessive exposure to LFN. The respiratory tract continues to be under heavy scrutiny in both LFN-exposed humans and animal models and has been confirmed as a major target for LFN-induced damage. Given that both the respiratory and central nervous systems were compromised in these workers, it became pertinent to investigate the status of the neurological control of breathing in VAD patients. The P- 0.1 value, a measure of the suction pressure developed at the mouth 0.1 seconds after the start of inspiration, depends on the respiratory centres and the autonomic nervous system pathway of the neural control of respiratory function. By rebreathing CO2, (6% in air) normal individuals present an average seven-fold increase in P0.1 (CO2) as compared to basal P- 0.1. Twenty-two male VAD patients (ave. age 50.5 +/- 8.5 years, range: 36-66 years) underwent the P0.1(CO2) index respiratory drive tests, as well as standard pulmonary function tests. Seven individuals (ave. age 42.4 +/-14 years, range: 25- 61 years) with reduced LFN exposure served as controls. Pulmonary function tests were normal in both VAD patients and controls. The P0.1 (CO2) in- dex was below average value in VAD patients (average: 22.9%) while it presented normal values in the control group (average > 60%). In the involuntary response to increased PCO2 levels, central chemoreceptors are responsible for 70% of the ventilatory stimulus. In VAD patients, this dysfunction may originate in the brainstem. This is corroborated by the fact that VAD patients register abnormal values for auditory brainstem evoked potentials, and disclose lesions with magnetic resonance imaging. The neurological control of breathing is compromised in VAD patients. The P0.1 (CO2) index may be a useful clinical indicator for VAD diagnosis and follow-up.

  4. Respiratory squamous cell carcinomas in vibroacoustic disease.

    Science.gov (United States)

    Reis Ferreira, José; Mendes, Carla P; Alves-Pereira, Mariana; Castelo Branco, Nuno A A

    2006-01-01

    In 1987, the autopsy of a vibroacoustic disease (VAD) patient disclosed two tumours: a renal cell carcinoma and a malignant glioma in the brain. Since 1987, malignancy in VAD patients has been under close surveillance. To date, in a universe of 945 individuals, there are 46 cases of malignancies, of which 11 are multiple. Of the 11 cases of respiratory tract tumours, all were squamous cell carcinomas (SqCC). This report focuses on the morphological features of these tumours. Tumour fragments were collected (endoscopic biopsy or surgery) from 11 male VAD patients (ave. age: 58+/-9 years, 3 non-smokers): 2 in glottis and 9 in the lung. In the 3 non-smokers, 2 had lung tumours and 1 had a glottis tumour. All were employed as or retired aircraft technicians, military or commercial pilots. Fragments were fixed either for light and electron microscopy. Immunohistochemistry studies used chromagranine and synaptophysine staining. All lung tumours were located in the upper right lobe bronchi and were histologically poorly differentiated SqCC (Figs. 1, 2). The search with neuroendocrine markers was negative. The average age of tumour onset in helicopter pilots was below 50 years old while for the other professional groups it was above 50. Nine patients are deceased. The 2 surviving patients are heavy smokers (> 2 packs/day). Smoking habits had no influence on tumour outcome and progression. Epidemiological studies indicate that squamous cell carcinomas account for approximately 40% of all lung tumours in men. It seems to be highly relevant that all VAD patient respiratory tract tumours are squamous cell carcinomas. It is not surprising that helicopter pilots are the ones who are affected the earliest because previous studies have shown that helicopter pilots exhibited the highest values for the frequency of sister chromatid exchanges. Generally, epidemiological tumor studies do not take histological tumor type into account, but given the results herein, it would seem of the

  5. Development and Optimisation of the SPS and LHC beam diagnostics based on Synchrotron Radiation monitors

    CERN Document Server

    AUTHOR|(CDS)2081364; Roncarolo, Federico

    Measuring the beam transverse emittance is fundamental in every accelerator, in particular for colliders, where its precise determination is essential to maximize the luminosity and thus the performance of the colliding beams.
 Synchrotron Radiation (SR) is a versatile tool for non-destructive beam diagnostics, since its characteristics are closely related to those of the source beam. At CERN, being the only available diagnostics at high beam intensity and energy, SR monitors are exploited as the proton beam size monitor of the two higher energy machines, the Super Proton Synchrotron (SPS) and the Large Hadron Collider (LHC). The thesis work documented in this report focused on the design, development, characterization and optimization of these beam size monitors. Such studies were based on a comprehensive set of theoretical calculations, numerical simulations and experiments. A powerful simulation tool has been developed combining conventional softwares for SR simulation and optics design, thus allowing t...

  6. Comparison of the vibroacoustical characteristics of different pianos

    CERN Document Server

    Boutillon, Xavier; Paulello, Stephen

    2012-01-01

    On the basis of a recently proposed vibro-acoustical model of the piano soundboard (X. Boutillon and K. Ege, Vibroacoustics of the piano soundboard: reduced models, mobility synthesis, and acoustical radiation regime. \\emph{submitted to the Journal of Sound and Vibration}, 2011.), we present several models for the coupling between the bridge and the ribbed plate of the soundboard. The models predict the modal density and the characteristic impedance at the bridge as a function of the frequency. Without parameter adjustment, the sub-structure model turns out to fit the experimental data with an excellent precision. The influence of the elastic parameters of wood is discussed. The model predictions are compared for pianos of different sizes and types.

  7. Vibroacoustic Analysis of Large Heat Rejection Radiators for Future Spacecraft

    Science.gov (United States)

    Larko, Jeffrey M.; McNelis, Mark E.; Hughes, William O.

    2006-01-01

    Spacecraft structures such as antennas, solar arrays and radiator panels significantly respond to high acoustic levels seen at lift-off. Some future spacecraft may utilize nuclear electric propulsion that require large radiator panels to reject waste heat. A vibroacoustic assessment was performed for two different radiator panel designs. Results from the analysis of the two designs using different analytical approaches are presented and discussed.

  8. Vibro-acoustic modulation–based damage identification in a composite skin–stiffener structure

    NARCIS (Netherlands)

    Ooijevaar, T.H.; Rogge, M.D.; Loendersloot, Richard; Warnet, Laurent; Akkerman, Remko; Tinga, Tiedo

    2016-01-01

    Vibro-acoustic modulation–based damage identification relies on the modulation of a high-frequency carrier signal by an intenser low-frequency vibration signal due to damage-induced structural nonlinearities. A time domain analysis of the vibro-acoustic modulation phenomena was presented at multiple

  9. Experimental studies of the vibroacoustic characteristics of a large-scale energy pump

    Energy Technology Data Exchange (ETDEWEB)

    Gaev, G.P.; Kail, I.I.; Kinski, D.; Koban, I.; Zhileiko, P.G.

    1986-06-01

    The results are given from experimental studies of the vibroacoustic characteristics of a large-scale energy (velocity) pump for the purpose of diagnosing its state under various service operating conditions. Recommendations are given for measuring the statistical characteristics of vibroacoustic pump noise.

  10. Effects of Vibroacoustic Music on Challenging Behaviors in Individuals with Autism and Developmental Disabilities

    Science.gov (United States)

    Lundqvist, Lars-Olov; Andersson, Gunilla; Viding, Jane

    2009-01-01

    Vibroacoustic music has been proposed to be an effective treatment for individuals with developmental disorders and challenging behaviors. The present study experimentally tested the effects of vibroacoustic music on self-injurious, stereotypical, and aggressive destructive behaviors in 20 individuals with autism spectrum disorders and…

  11. Application of the Bootstrap Statistical Method in Deriving Vibroacoustic Specifications

    Science.gov (United States)

    Hughes, William O.; Paez, Thomas L.

    2006-01-01

    This paper discusses the Bootstrap Method for specification of vibroacoustic test specifications. Vibroacoustic test specifications are necessary to properly accept or qualify a spacecraft and its components for the expected acoustic, random vibration and shock environments seen on an expendable launch vehicle. Traditionally, NASA and the U.S. Air Force have employed methods of Normal Tolerance Limits to derive these test levels based upon the amount of data available, and the probability and confidence levels desired. The Normal Tolerance Limit method contains inherent assumptions about the distribution of the data. The Bootstrap is a distribution-free statistical subsampling method which uses the measured data themselves to establish estimates of statistical measures of random sources. This is achieved through the computation of large numbers of Bootstrap replicates of a data measure of interest and the use of these replicates to derive test levels consistent with the probability and confidence desired. The comparison of the results of these two methods is illustrated via an example utilizing actual spacecraft vibroacoustic data.

  12. An Approximate Analytical Method of the Nonlinear Vibroacoustic Coupling System

    Directory of Open Access Journals (Sweden)

    Qizheng Zhou

    2014-01-01

    Full Text Available An approximate analytical method of the nonlinear vibroacoustic coupling system is proposed for the first time. Taking the Duffing oscillator-plate-medium system as an example, the nonlinear vibroacoustic coupling equations are developed using variational principle. The two major difficulties which lie in solving the coupling equations are the uncertain motion of the oscillator and the surface acoustic pressure on the plate, a system for which the fluid-structure coupling cannot be neglected. Based on the incremental harmonic balance (IHB method, the motion of the oscillator is expressed in the form of the Fourier series, and then the modal expression method and the incoherent assumption are employed to discretize the displacement and the surface pressure of the plate. Then the approximate analytical solution is given by the IHB method. The characteristics of acoustic radiation and surface quadratic velocity of the plate, the nonlinear characteristics of oscillator, and the influence of the excitation frequency and the nonlinear stiffness on the results are investigated by the numerical simulation. The results show that the excitation at the frequency close to the natural frequency of the oscillator can produce a significant response of the third-harmonic generation which determines the vibroacoustic characteristics of the plate.

  13. Filtration of sunflower oil in the field of vibroacoustic effects

    Directory of Open Access Journals (Sweden)

    S. A. Bredikhin

    2017-01-01

    Full Text Available Purification of crude unrefined sunflower oil along with the removal of primary oxidation products is an urgent task to remove the solid constituents formed during the processing of sunflower seeds. All of them irrespective of the chemical composition negatively affect the quality of the food product and, over time, saturate the oil with coagulants that affect its organoleptic and physico-mechanical characteristics. The problem of cleaning unrefined sunflower oil by filtration with the use of vibroacoustic action is considered. The calculation scheme of the process is given, and an experimental setup has been developed that makes it possible to vary the angle of inclination of the filter element. The research of sunflower oil filtration in the field of vibroacoustic impact is carried out. In the study, a decision was made to expand the energy effects to create a cumulative system in the liquid medium that improves the hydrodynamic situation at the scale of the oil purification plant. It is established that the process speed can be intensified by creating additional microflows that provide an active influence on the motion of liquid, gas and solid particles. The results are obtained, which testify to the effectiveness of the use of vibroacoustic effects during the filtration of sunflower oil.

  14. Diagnostic value and prognostic evaluation of dynamic video-electroencephalogram monitoring in children with epilepsy

    Science.gov (United States)

    Wu, Xiaobo; Su, Ying; Liu, Wei; Jia, Xiaoyu; Zhang, Yanling; Zhang, Xinyang; Wang, Guilan

    2017-01-01

    The diagnostic and prognostic value of dynamic video-electroencephalogram (V-EEG) monitoring in children with epilepsy were investigated. From February 2014 to February 2016, in total 200 children with epilepsy were selected during their stay in the First Hospital of Qinghuangdao and were randomly allocated to a dynamic and a conventional V-EEG monitoring group (n=100). The detection rate of epileptiform discharges in the two groups was evaluated. The V-EEG monitoring index was used to select treatment methods for patients with epilepsy. After 3 months, the patients were rechecked. Disease features and incidence of epilepsy were recorded. There were no significant differences in the course of disease, seizure frequency and age between the two groups (P>0.05). The detection rate of epileptiform discharges in the dynamic V-EEG was significantly higher than in the routine monitoring group (P<0.01). The accuracy and specificity of monitoring in the V-EEG were significantly higher than in the routine monitoring group (P<0.01). Seizure frequency and number of epilepsy attacks in patients in the V-EEG group were significantly lower than in the routine monitoring group (P<0.01). Dynamic V-EEG can improve epilepsy detection rate. The high accuracy and specificity of dynamic V-EEG suggest that it may be of great clinical value in the diagnosis and prognosis of epilepsy. PMID:28962191

  15. Diagnostic Yield of Extended Cardiac Patch Monitoring in Patients with Stroke or TIA.

    Science.gov (United States)

    Tung, Christie E; Su, Derek; Turakhia, Mintu P; Lansberg, Maarten G

    2014-01-01

    It is important to evaluate patients with transient ischemic attack (TIA) or stroke for atrial fibrillation (AF) because the detection of AF changes the recommended anti-thrombotic regimen from treatment with an antiplatelet agent to oral anticoagulation. This study describes the diagnostic yield of a patch-based, single-use, and water-resistant 14-day continuous cardiac rhythm monitor (ZIO Patch) in patients with stroke or TIA. We obtained data from the manufacturer and servicer of the ZIO Patch (iRhythm Technologies). Patients who were monitored between January 2012 and June 2013 and whose indication for monitoring was TIA or stroke were included. The duration of monitoring, the number and type of arrhythmias, and the time to first arrhythmia were documented. One thousand one hundred seventy-one monitoring reports were analyzed. The mean monitor wear time was 10.9 days and the median wear time was 13.0 days (interquartile range 7.2-14.0). The median analyzable time relative to the total wear time was 98.7% (IQR 96.0-99.5%). AF was present in 5.0% of all reports. The mean duration before the first episode of paroxysmal AF (PAF) was 1.5 days and the median duration was 0.4 days. 14.3% of first PAF episodes occurred after 48 h. The mean PAF burden was 12.7% of the total monitoring duration. Excellent quality of the recordings and very good patient compliance coupled with a substantial proportion of AF detection beyond the first 48 h of monitoring suggest that the cardiac patch is superior to conventional 48-h Holter monitors for AF detection in patients with stroke or TIA.

  16. Diagnostic Yield of Extended Cardiac Patch Monitoring in Patients with Stroke or TIA

    Directory of Open Access Journals (Sweden)

    Christie E Tung

    2015-01-01

    Full Text Available Background: It is important to evaluate patients with TIA or stroke for atrial fibrillation (AF because the detection of AF changes the recommended anti-thrombotic regimen from treatment with an antiplatelet agent to oral anticoagulation. This study describes the diagnostic yield of a patch-based, single-use, and water-resistant 14-day continuous cardiac rhythm monitor (ZIO Patch in patients with stroke or TIA.Methods: We obtained data from the manufacturer and servicer of the ZIO Patch (iRhythm Technologies. Patients who were monitored between January 2012 and June 2013 and whose indication for monitoring was TIA or stroke were included. The duration of monitoring, the number and type of arrhythmias, and the time to first arrhythmia were documented. Results: 1,171 monitoring reports were analyzed. The mean monitor wear time was 10.9 days and the median wear time was 13.0 days (interquartile range 7.2-14.0. The median analyzable time relative to the total wear time was 98.7% (IQR 96.0-99.5%. AF was present in 5.0% of all reports. The mean duration before the first episode of paroxysmal AF (PAF was 1.5 days and the median duration was 0.4 days. 14.3% of first PAF episodes occurred after 48 hours. The mean PAF burden was 12.7% of the total monitoring duration. Conclusion: Excellent quality of the recordings and very good patient compliance coupled with a substantial proportion of AF detection beyond the first 48 hours of monitoring suggest that the cardiac patch is superior to conventional 48-hour Holter monitors for AF detection in patients with stroke or TIA.

  17. Optical diagnostics of selective laser melting and monitoring of single-track formation

    Directory of Open Access Journals (Sweden)

    Gusarov Andrey

    2017-01-01

    Full Text Available The article presents the optical diagnostics results of the selective laser melting process of single-track production. The track defects detection (such as balling effect, powder free zone formation, sparking was shown, as well as the visualization of the independent particles consolidation in a solid track. The metal evaporation and the formation of the melt pool specific gas dynamic conditions were considered as important physical phenomena. The velocities of the particle emission from the melt pool, the rate of their involvement, and the velocity of the gas flow were estimated. The results make it possible to evaluate the kinetics of mass transfer under selective laser melting process. The surface thermal field of the laser-irradiated zone strongly influences the material qualitative characteristics after selective laser melting. The results becomes the basis for the development of optical monitoring and diagnostic systems for laser additive manufacturing processes based on the melt pool temperature online controlling.

  18. Diagnostic value and prognostic evaluation of dynamic video-electroencephalogram monitoring in children with epilepsy.

    Science.gov (United States)

    Wu, Xiaobo; Su, Ying; Liu, Wei; Jia, Xiaoyu; Zhang, Yanling; Zhang, Xinyang; Wang, Guilan

    2017-09-01

    The diagnostic and prognostic value of dynamic video-electroencephalogram (V-EEG) monitoring in children with epilepsy were investigated. From February 2014 to February 2016, in total 200 children with epilepsy were selected during their stay in the First Hospital of Qinghuangdao and were randomly allocated to a dynamic and a conventional V-EEG monitoring group (n=100). The detection rate of epileptiform discharges in the two groups was evaluated. The V-EEG monitoring index was used to select treatment methods for patients with epilepsy. After 3 months, the patients were rechecked. Disease features and incidence of epilepsy were recorded. There were no significant differences in the course of disease, seizure frequency and age between the two groups (P>0.05). The detection rate of epileptiform discharges in the dynamic V-EEG was significantly higher than in the routine monitoring group (Pmonitoring in the V-EEG were significantly higher than in the routine monitoring group (Pmonitoring group (P<0.01). Dynamic V-EEG can improve epilepsy detection rate. The high accuracy and specificity of dynamic V-EEG suggest that it may be of great clinical value in the diagnosis and prognosis of epilepsy.

  19. A Vibroacoustic Database Management Center for Shuttle and expendable launch vehicle payloads

    Science.gov (United States)

    Thomas, Valerie C.

    1987-01-01

    A Vibroacoustic Database Management Center has recently been established at the Jet Propulsion Laboratory (JPL). The center uses the Vibroacoustic Payload Environment Prediction System (VAPEPS) computer program to maintain a database of flight and ground-test data and structural parameters for both Shuttle and expendable launch-vehicle payloads. Given the launch-vehicle environment, the VAPEPS prediction software, which employs Statistical Energy Analysis (SEA) methods, can be used with or without the database to establish the vibroacoustic environment for new payload components. This paper summarizes the VAPEPS program and describes the functions of the Database Management Center at JPL.

  20. Parametric evaluation of the cost effectiveness of Shuttle payload vibroacoustic test plans

    Science.gov (United States)

    Stahle, C. V.; Gongloff, H. R.; Keegan, W. B.; Young, J. P.

    1978-01-01

    Consideration is given to alternate vibroacoustic test plans for sortie and free flyer Shuttle payloads. Statistical decision models for nine test plans provide a viable method of evaluating the cost effectiveness of alternate vibroacoustic test plans and the associated test levels. The methodology is a major step toward the development of a useful tool for the quantitative tailoring of vibroacoustic test programs to sortie and free flyer payloads. A broader application of the methodology is now possible by the use of the OCTAVE computer code.

  1. Damage imaging in nonlinear vibro-acoustic modulation tests

    Science.gov (United States)

    Pieczonka, Lukasz; Klepka, Andrzej; Uhl, Tadeusz; Staszewski, Wieslaw J.

    2015-03-01

    The paper deals with the nonlinear vibro-acoustic modulation technique (VAM) used for nondestructive damage detection in composites. In its original form the technique allows only for the determination of the presence of damage in a structure. This paper presents an enhancement of the technique that allows also for the determination of damage location. Experimental testing of the proposed procedure is performed on carbon fiber/epoxy laminated composite plates with barely visible impact damage that was generated in an impact test. Shearography was used to verify damage location. Piezoceramic actuators are used for vibration excitation and a scanning laser vibrometer is used for data acquisition.

  2. Mechanical modelling and application of vibroacoustic isolators in railway tracks

    Directory of Open Access Journals (Sweden)

    Zbiciak Artur

    2017-01-01

    Full Text Available The paper presents systematization and description of vibroacoustic isolators used in railway tracks (due to track structure type, with special attention paid to resilient mats. As in the second part of the paper the state-space mechanical model of a system with Under-Ballast Mat is formulated. Also some numerical problems arising from the mass matrix singularity are discussed. The poles of the system were calculated by using Matlab. Moreover, the influence of various parameters on the system’s insertion loss and its transmissibility was visualized in figures.

  3. Feasibility Investigation on the Development of a Structural Damage Diagnostic and Monitoring System for Rocket Engines

    Science.gov (United States)

    Shen, Ji Y.; Sharpe, Lonnie, Jr.

    1998-01-01

    The research activity for this project is mainly to investigate the necessity and feasibility to develop a structural health monitoring system for rocket engines, and to carry out a research plan for further development of the system. More than one hundred technical papers have been searched and reviewed during the period. We concluded after this investigation that adding a new module in NASA's existing automated diagnostic system to monitor the healthy condition of rocket engine structures is a crucial task, and it's possible to develop such a system based upon the vibrational-based nondestructive damage assessment techniques. A number of such techniques have been introduced. Their advantages and disadvantages are also discussed. A global research plan has been figured out. As the first step of the overall research plan, a proposal for the next fiscal year has been submitted.

  4. Reverse iontophoresis of urea in health and chronic kidney disease: a potential diagnostic and monitoring tool?

    Science.gov (United States)

    Ebah, Leonard M; Read, Ian; Sayce, Andrew; Morgan, Jane; Chaloner, Christopher; Brenchley, Paul; Mitra, Sandip

    2012-01-01

    Background Patients with chronic kidney disease (CKD) need regular monitoring, usually by blood urea and creatinine measurements, needing venepuncture, frequent attendances and a healthcare professional, with significant inconvenience. Noninvasive monitoring will potentially simplify and improve monitoring. We tested the potential of transdermal reverse iontophoresis of urea in patients with CKD and healthy controls. Methods Using a MIC 2® Iontophoresis Controller, reverse iontophoresis was applied on the forearm of five healthy subjects (controls) and 18 patients with CKD for 3–5 h. Urea extracted at the cathode was measured and compared with plasma urea. Results Reverse iontophoresis at 250 μA was entirely safe for the duration. Cathodal buffer urea linearly correlated with plasma urea after 2 h (r = 0·82, P urea (y) from cathodal urea after 2 and 3 h, respectively. Cathodal urea concentration in controls was significantly lower than in patients with CKD after a minimum current application of 2 h (P urea cut-off of 30 μM gave a sensitivity of 83·3% and positive predictive value of 87% CKD. During haemodialysis, the fall in cathodal urea was able to track that of blood urea. Conclusion Reverse iontophoresis is safe, can potentially discriminate patients with CKD and healthy subjects and is able to track blood urea changes on dialysis. Further development of the technology for routine use can lead to an exciting opportunity for its use in diagnostics and monitoring. PMID:22409780

  5. A Model-based Health Monitoring and Diagnostic System for the UH-60 Helicopter. Appendix D

    Science.gov (United States)

    Patterson-Hine, Ann; Hindson, William; Sanderfer, Dwight; Deb, Somnath; Domagala, Chuck

    2001-01-01

    Model-based reasoning techniques hold much promise in providing comprehensive monitoring and diagnostics capabilities for complex systems. We are exploring the use of one of these techniques, which utilizes multi-signal modeling and the TEAMS-RT real-time diagnostic engine, on the UH-60 Rotorcraft Aircrew Systems Concepts Airborne Laboratory (RASCAL) flight research aircraft. We focus on the engine and transmission systems, and acquire sensor data across the 1553 bus as well as by direct analog-to-digital conversion from sensors to the QHuMS (Qualtech health and usage monitoring system) computer. The QHuMS computer uses commercially available components and is rack-mounted in the RASCAL facility. A multi-signal model of the transmission and engine subsystems enables studies of system testability and analysis of the degree of fault isolation available with various instrumentation suites. The model and examples of these analyses will be described and the data architectures enumerated. Flight tests of this system will validate the data architecture and provide real-time flight profiles to be further analyzed in the laboratory.

  6. Materiomics for Oral Disease Diagnostics and Personal Health Monitoring: Designer Biomaterials for the Next Generation Biomarkers

    Science.gov (United States)

    Zhang, Wenjun; Wang, Ming L.; Khalili, Sammy

    2016-01-01

    Abstract We live in exciting times for a new generation of biomarkers being enabled by advances in the design and use of biomaterials for medical and clinical applications, from nano- to macro-materials, and protein to tissue. Key challenges arise, however, due to both scientific complexity and compatibility of the interface of biology and engineered materials. The linking of mechanisms across scales by using a materials science approach to provide structure–process–property relations characterizes the emerging field of ‘materiomics,’ which offers enormous promise to provide the hitherto missing tools for biomaterial development for clinical diagnostics and the next generation biomarker applications towards personal health monitoring. Put in other words, the emerging field of materiomics represents an essentially systematic approach to the investigation of biological material systems, integrating natural functions and processes with traditional materials science perspectives. Here we outline how materiomics provides a game-changing technology platform for disruptive innovation in biomaterial science to enable the design of tailored and functional biomaterials—particularly, the design and screening of DNA aptamers for targeting biomarkers related to oral diseases and oral health monitoring. Rigorous and complementary computational modeling and experimental techniques will provide an efficient means to develop new clinical technologies in silico, greatly accelerating the translation of materiomics-driven oral health diagnostics from concept to practice in the clinic. PMID:26760957

  7. Global sensitivity analysis of analytical vibroacoustic transmission models

    Science.gov (United States)

    Christen, Jean-Loup; Ichchou, Mohamed; Troclet, Bernard; Bareille, Olivier; Ouisse, Morvan

    2016-04-01

    Noise reduction issues arise in many engineering problems. One typical vibroacoustic problem is the transmission loss (TL) optimisation and control. The TL depends mainly on the mechanical parameters of the considered media. At early stages of the design, such parameters are not well known. Decision making tools are therefore needed to tackle this issue. In this paper, we consider the use of the Fourier Amplitude Sensitivity Test (FAST) for the analysis of the impact of mechanical parameters on features of interest. FAST is implemented with several structural configurations. FAST method is used to estimate the relative influence of the model parameters while assuming some uncertainty or variability on their values. The method offers a way to synthesize the results of a multiparametric analysis with large variability. Results are presented for transmission loss of isotropic, orthotropic and sandwich plates excited by a diffuse field on one side. Qualitative trends found to agree with the physical expectation. Design rules can then be set up for vibroacoustic indicators. The case of a sandwich plate is taken as an example of the use of this method inside an optimisation process and for uncertainty quantification.

  8. The Effect of Vibroacoustic Stimulation and Music on Fetal Movement

    Directory of Open Access Journals (Sweden)

    Masoume Pirhadi

    2015-09-01

    Full Text Available Introduction Fetal movement started at the 7th weeks of pregnancy and by the end of pregnancy will gradually be perfect and harmonious. Near-term fetuses can discriminate acoustic features, such as frequencies and spectra, and process complex auditory streams. In this study, we aimed to evaluate fatal movement in response to music and vibration stimulation. Materials and Methods This study is a clinical trial that was conducted in two groups and two-steps. Participants were pregnant women (primigravida who have referring to the Shahid Beheshti Hospital in Isfahan during 2013 to receive routine prenatal care. The 64 pregnant women (32-36 weeks were randomly assigned to the groups of Vibroacoustic stimulation (n= 32 and Music (n=32. They were stimulated immediately after the first non stress test and before the second test. The researchers’ evaluated and analyzed possible changes in non-stress test results using SPSS software version 20. Results Mean age of the subjects in vibroacoustic group and in music group were (25.5±2.6 (24.9±4.4 respectively. Paired t-test showed there was no relationship between the average number of acceleration of the fetal heart rate before and after the intervention (P>0.05.On the other hand, there was a significant correlation between the average number of fetal movements in the music group before and after the intervention (P

  9. Vibroacoustic stimulation in abnormal biophysical profile: verification of facilitation of fetal well-being.

    Science.gov (United States)

    Papadopoulos, Vassilis G; Decavalas, George O; Kondakis, Xenophon G; Beratis, Nicholas G

    2007-03-01

    To verify the effect of vibroacoustic stimulation on biophysical profile score, with a prospective randomised study. All women with singleton pregnancy, gestational age >or=30 weeks, intact membranes and biophysical profile score vibroacoustic stimulation does not alter test's statistical parameters. 1349 patients were randomised in group A and 1484 in group B (2833 in total). When comparing group A to B, application of vibroacoustic stimulation significantly decreased the number of positive tests (4.74% vs. 6.67%, pVibroacoustic stimulation improves the efficiency of biophysical profile score by decreasing false positive tests and improving test accuracy and should be considered as a means of a more thorough fetal evaluation when fetal compromise is suspected.

  10. Pointers, Lessons Learned, and Rules of Thumb for Successful Vibro-Acoustic Data Acquisition

    Science.gov (United States)

    Rossoni, Peter

    1998-01-01

    This presentation contains helpful pointers for successful vibroacoustic data acquisition in the following three areas: Instrumentation, Vibration Control and Pyro-shock data acquisition and analysis. A helpful bibliography is provided.

  11. Gender responsiveness diagnostic of national monitoring and evaluation systems – methodological reflections

    Directory of Open Access Journals (Sweden)

    Madri S. Jansen van Rensburg

    2017-04-01

    Full Text Available Background: This article reflects on the implementation of a diagnostic study carried out to understand the gender responsiveness of the national monitoring and evaluation (M&E systems of Benin, South Africa and Uganda. Carrying out the study found that the potential for integrating the cross-cutting systems of gender and monitoring and evaluation (M&E are strong. At the same time, it highlighted a range of challenges intersecting these two areas of work. This article explores these issues, which range from logistical to conceptual.Objectives: This article aims to share reflections from the gender diagnostic study to enable more appropriate capacity building in the field of gender responsiveness in national M&E systems. Developing more sophisticated tools to measure gender responsiveness in complex contexts is critical. A better understanding of how gender and national M&E systems intersect is important to understanding firstly how we can more accurately measure the gender responsiveness of existing systems and secondly how better to engender capacity development initiatives.Method: As part of the Twende Mbele programme, Centre for Learning on Evaluation and Results (CLEAR commissioned Africa Gender and Development Evaluator’s Network (AGDEN to coordinate teams of researchers in Benin, Uganda, and South Africa to collaboratively develop the diagnostic tool, and then implement it by conducting a review of key documentation and to interview officials within the government wide monitoring and evaluation systems as well as the national gender machinery in each country.Results: The study found that the gender responsiveness of M&E systems across all three systems was unequal, but more importantly, it is important to do more work on how M&E and gender are conceptualised, to ensure this can be studied in a more meaningful way. To strengthen national monitoring and evaluation systems, gender responsiveness and equity must serve as a foundation for

  12. Cross-over trial of fetal heart rate response to halogen light and vibroacoustic stimulation.

    Science.gov (United States)

    Bolnick, Jay M; Garcia, Greg; Fletcher, Beverly G; Rayburn, William F

    2006-04-01

    The purpose of this study was to compare the effect of halogen light and vibroacoustic stimulation on fetal heart rate (FHR) responsiveness and on nonstress test (NST) results. Sixty consecutively-chosen patients between 33 and 39 weeks of gestation underwent an NST on at least three weekly occasions. Each received halogen light (Vector Compact Sport Spot, Ft Lauderdale, FL, USA), vibroacoustic (SolaTone Artificial Larynx, Temecula, CA, USA), and no stimulation in a randomized order. The transabdominal light or vibroacoustic stimulation lasted for 10 seconds. If no initial FHR acceleration occurred, then the stimulus was repeated 10 minutes later up to a maximum of three times. The investigators who interpreted the FHR patterns were blinded as to the type of stimulus used. Reactive results were present in 171 tests (vibroacoustic: 98.3%; light: 96.6%; none: 93.3%). Compared with no stimulation, the mean difference in time from the onset of recorded "stimulation" to the first FHR acceleration was shorter (p vibroacoustic stimulation (2.6 minutes, 95% CI 0.8-4.4 minutes). The mean time difference until a reactive result was also shorter (p vibroacoustic stimulation (2.4 minutes, 95% CI 0.1-4.7 minutes) than with no stimulation. The need for repeated stimulation during each test was infrequent (light: 5.0%; vibroacoustic: 3.3%). No adverse effect from external stimulation was noted on the FHR tracing. Halogen light stimulation is an acceptable alternative to vibroacoustic stimulation in provoking a more rapid fetal heart rate response and in shortening the time before a reactive nonstress test result.

  13. Research activities on vibro-acoustics of satellites during rocket launch

    OpenAIRE

    Murakami, Keiichi; Inada, Yoshinobu; Aoyama, Takashi; Takahashi, Takashi; Aiso, Hideaki; 村上 桂一; 稲田 喜信; 青山 剛史; 高橋 孝; 相曽 秀昭

    2006-01-01

    A study to establish a prediction method for vibro-acoustics of satellites during rocket launch has been conducted using a multidisciplinary analysis method of fluid, acoustic, and vibration. This coupling method consists of following four elements: numerical analyses of (1) sound generation, (2) sound propagation, (3) sound permeation, and (4) vibro-acoustics of payload. In the sound generation analysis, it can be seen from FEM analysis of a simply modeled deflector that a strong resonance o...

  14. Non-Destructive Testing for Building Diagnostics and Monitoring: Experience Achieved with Case Studies

    Directory of Open Access Journals (Sweden)

    Tavukçuoğlu Ayşe

    2018-01-01

    Full Text Available Building inspection on site, in other words in-situ examinations of buildings is a troublesome work that necessitates the use of non-destructive investigation (NDT techniques. One of the main concerns of non-destructive testing studies is to improve in-situ use of NDT techniques for diagnostic and monitoring studies. The quantitative infrared thermography (QIRT and ultrasonic pulse velocity (UPV measurements have distinct importance in that regard. The joint use of QIRT and ultrasonic testing allows in-situ evaluation and monitoring of historical structures and contemporary ones in relation to moisture, thermal, materials and structural failures while the buildings themselves remain intact. For instances, those methods are useful for detection of visible and invisible cracks, thermal bridges and damp zones in building materials, components and functional systems as well as for soundness assessment of materials and thermal performance assessment of building components. In addition, those methods are promising for moisture content analyses in materials and monitoring the success of conservation treatments or interventions in structures. The in-situ NDT studies for diagnostic purposes should start with the mapping of decay forms and scanning of building surfaces with infrared images. Quantitative analyses are shaped for data acquisition on site and at laboratory from representative sound and problem areas in structures or laboratory samples. Laboratory analyses are needed to support in-situ examinations and to establish the reference data for better interpretation of in situ data. Advances in laboratory tests using IRT and ultrasonic testing are guiding for in-situ materials investigations based on measurable parameters. The knowledge and experience on QIRT and ultrasonic testing are promising for the innovative studies on today’s materials technologies, building science and conservation/maintenance practices. Such studies demand a multi

  15. PREFACE: 25th International Congress on Condition Monitoring and Diagnostic Engineering (COMADEM 2012)

    Science.gov (United States)

    Ball, Andrew; Mishra, Rakesh; Gu, Fengshou; Rao, Raj B. K. N.

    2012-05-01

    The proactive multidisciplinary conceptual philosophy of Condition Monitoring and Diagnostic Engineering Management (COMADEM) was conceived and has been nurtured, developed and sustained since 1988. Since then, it is gratifying to note that the condition monitoring, diagnostic and prognostic community worldwide (representing industrialists, academics, research and development organizations, professional/private establishments and many hardware/software vending organizations) has warmly welcomed and supported this venture. As is evidenced, many have reaped (and are reaping) the benefits of COMADEM interdiscipline through continuous knowledge discovery, generation and dissemination. We are now proud to celebrate the 25th Annual Event (Silver Jubilee) in Huddersfield, the most beautiful part of the United Kingdom. The theme of this Congress is 'Sustained Prosperity through Proactive Monitoring, Diagnosis, Prognosis and Management'. This proceedings is enriched by contributions from many keynote experts representing many industry and academic establishments worldwide. Authors from more than 30 different countries have pooled their rich multidisciplinary up-to-date knowledge, in order to share their invaluable experience with the COMADEM community. In this proceedings, the readers will find more than 120 refereed papers encompassing a number of topical areas of interest relating to the theme of the congress. The proceedings of COMADEM 2012 will appear in the Open Access Journal of Physics: Conference Series (JPCS), which is part of the IOP Conference Series. All papers published in the IOP Conference Series are fully citable and upon publication will be free to download. We would like to express our deep gratitude to all the keynote speakers, authors, referees, exhibitors, Technical Co-Sponsoring Organizations, Gold Sponsors, IOP Publishers, COMADEM 2012 organizing committee members, delegates and many others on whom the success of this prestigious event depends

  16. Diagnostic means, possibilities and prospects of using them in the coal industry

    Energy Technology Data Exchange (ETDEWEB)

    Levites, I.A.; Shumeiko, S.V. (Donetskii Nauchno-Issledovatel' skii Ugol' nyi Institut (Ukraine))

    1992-10-01

    Reports on portable, sparkproof, vibroacoustic diagnostic equipment developed at the DonUGI institute. Indicators of leakage in hydraulic systems, the condition of reductors or electric induction motors (IGK, ISR, IDEh respectively) were produced and delivered in 1992. Prototypes of stands for dynamic balancing of components of rotating machines are planned to be built in 1992. Diagnostic equipment is capable of evaluating the quality of manufacturing or repair by measuring vibroacoustic parameters. Development of apparatus for location of faults in electric power cables used in coal mines is planned for 1992-1993. Specifications of equipment produced are provided.

  17. An Integrated Architecture for On-Board Aircraft Engine Performance Trend Monitoring and Gas Path Fault Diagnostics

    Science.gov (United States)

    Simon, Donald L.

    2010-01-01

    Aircraft engine performance trend monitoring and gas path fault diagnostics are closely related technologies that assist operators in managing the health of their gas turbine engine assets. Trend monitoring is the process of monitoring the gradual performance change that an aircraft engine will naturally incur over time due to turbomachinery deterioration, while gas path diagnostics is the process of detecting and isolating the occurrence of any faults impacting engine flow-path performance. Today, performance trend monitoring and gas path fault diagnostic functions are performed by a combination of on-board and off-board strategies. On-board engine control computers contain logic that monitors for anomalous engine operation in real-time. Off-board ground stations are used to conduct fleet-wide engine trend monitoring and fault diagnostics based on data collected from each engine each flight. Continuing advances in avionics are enabling the migration of portions of the ground-based functionality on-board, giving rise to more sophisticated on-board engine health management capabilities. This paper reviews the conventional engine performance trend monitoring and gas path fault diagnostic architecture commonly applied today, and presents a proposed enhanced on-board architecture for future applications. The enhanced architecture gains real-time access to an expanded quantity of engine parameters, and provides advanced on-board model-based estimation capabilities. The benefits of the enhanced architecture include the real-time continuous monitoring of engine health, the early diagnosis of fault conditions, and the estimation of unmeasured engine performance parameters. A future vision to advance the enhanced architecture is also presented and discussed

  18. Handbook of Coherent-Domain Optical Methods Biomedical Diagnostics, Environmental Monitoring, and Materials Science

    CERN Document Server

    2013-01-01

    This Handbook provides comprehensive coverage of laser and coherent-domain methods as applied to biomedicine, environmental monitoring, and materials science. Worldwide leaders in these fields describe the fundamentals of light interaction with random media and present an overview of basic research. The latest results on coherent and polarization properties of light scattered by random media, including tissues and blood, speckles formation in multiple scattering media, and other non-destructive interactions of coherent light with rough surfaces and tissues, allow the reader to understand the principles and applications of coherent diagnostic techniques. The expanded second edition has been thoroughly updated with particular emphasis on novel coherent-domain techniques and their applications in medicine and environmental science. Volume 1 describes state-of-the-art methods of coherent and polarization optical imaging, tomography and spectroscopy; diffusion wave spectroscopy; elastic, quasi-elastic and inelasti...

  19. Final Report on the Research Project Ringhals Diagnostics and Monitoring. Stage 4

    Energy Technology Data Exchange (ETDEWEB)

    Demaziere, C.; Arzhanov, V.; Karlsson, Joakim K.H.; Pazsit, I

    1999-07-01

    This report gives an account of the work performed by the Department of Reactor Physics in the frame of a research contract with Ringhals, Vattenfall AB. The contract constitutes Stage 4 of a long-term co-operative research work concerning diagnostics and monitoring of the BWR and PWR units. The work in Stage 4 has been performed between 1 October 1998 and 1 September 1999. In Stage 4 we have worked with four items as follows: 1. Regional modes in R1 stability measurements; 2. Analysis of data from the measurement 980604; 3. Study of the possibility of measuring the moderator temperature coefficient using noise methods. Literature survey and measurement evaluation; 4. Transfer of the method for determining axial control rod elevation. Current situation and progress.

  20. Method for Evaluating Information to Solve Problems of Control, Monitoring and Diagnostics

    Science.gov (United States)

    Vasil'ev, V. A.; Dobrynina, N. V.

    2017-06-01

    The article describes a method for evaluating information to solve problems of control, monitoring and diagnostics. It is necessary for reducing the dimensionality of informational indicators of situations, bringing them to relative units, for calculating generalized information indicators on their basis, ranking them by characteristic levels, for calculating the efficiency criterion of a system functioning in real time. The design of information evaluation system has been developed on its basis that allows analyzing, processing and assessing information about the object. Such object can be a complex technical, economic and social system. The method and the based system thereof can find a wide application in the field of analysis, processing and evaluation of information on the functioning of the systems, regardless of their purpose, goals, tasks and complexity. For example, they can be used to assess the innovation capacities of industrial enterprises and management decisions.

  1. Multipronged diagnostic approaches for monitoring the treatment of Brucella abortus infected patient: a case report

    Directory of Open Access Journals (Sweden)

    Rajeswari Shome

    2015-07-01

    Full Text Available Brucellosis caused by Brucella species is readily transmissible to humans, causing acute febrile illness and undulant fever which may progress to a more chronic form and can also produce serious complications affecting the musculoskeletal, cardiovascular, and central nervous systems. A veterinary livestock inspector presented to the institute with symptoms of intermittent fever, pain involving muscles and joints, loss of weight, anxiety and weakness for about three months has been investigated. The isolation, serological tests and PCR were performed for diagnosis of brucellosis. Based on history of constant professional association with animals, characteristic symptoms, hematological and biochemical, multiple serological and PCR assay results, the patient was diagnosed as brucellosis. Detection of Brucella abortus directly in the clinical samples by gel based PCRs were highly useful for diagnosis and monitoring of treatment. This diagnostic protocol will facilitate in a simple way to map major Brucella species infecting humans in a geographical region.

  2. Diagnosing psychogenic nonepileptic seizures: Video-EEG monitoring, suggestive seizure induction and diagnostic certainty.

    Science.gov (United States)

    Popkirov, Stoyan; Jungilligens, Johannes; Grönheit, Wenke; Wellmer, Jörg

    2017-08-01

    Psychogenic nonepileptic seizures (PNES) can remain undiagnosed for many years, leading to unnecessary medication and delayed treatment. A recent report by the International League Against Epilepsy Nonepileptic Seizures Task Force recommends a staged approach to the diagnosis of PNES (LaFrance, et al., 2013). We aimed to investigate its practical utility, and to apply the proposed classification to evaluate the role of long-term video-EEG monitoring (VEEG) and suggestive seizure induction (SSI) in PNES workup. Using electronic medical records, 122 inpatients (mean age 36.0±12.9years; 68% women) who received the diagnosis of PNES at our epilepsy center during a 4.3-year time period were included. There was an 82.8% agreement between diagnostic certainty documented at discharge and that assigned retroactively using the Task Force recommendations. In a minority of cases, having used the Task Force criteria could have encouraged the clinicians to give more certain diagnoses, exemplifying the Task Force report's utility. Both VEEG and SSI were effective at supporting high level diagnostic certainty. Interestingly, about one in four patients (26.2%) had a non-diagnostic ("negative") VEEG but a positive SSI. On average, this subgroup did not have significantly shorter mean VEEG recording times than VEEG-positive patients. However, VEEG-negative/SSI-positive patients had a significantly lower habitual seizure frequency than their counterparts. This finding emphasizes the utility of SSI in ascertaining the diagnosis of PNES in patients who do not have a spontaneous habitual event during VEEG due to, for example, low seizure frequency. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Final report on the research project Ringhals diagnostics and monitoring. Stage 5

    Energy Technology Data Exchange (ETDEWEB)

    Demaziere, C.; Arzhanov, V.; Pazsit, I

    2000-09-01

    This report gives an account of the work performed by the Department of Reactor Physics in the frame of a research contract with Ringhals, Vattenfall AB. The contract constitutes Stage 5 of a long-term co-operative research work concerning diagnostics and monitoring of the BWR and PWR units. The work in Stage 5 has been performed between October 1999 and September 2000. In Stage 5 we have worked with four items as follows: 1. MTC measurement using the boron dilution method: Analysis of a measurement performed at Ringhals-4; 2. Analysis of the noise measurement performed at Ringhals-2 with the use of gamma thermometers; 3. Development of a method for diagnostics of shell-mode core-barrel vibrations via noise measurements with in-core neutron detectors; 4. A preliminary inventory of the needs and possibilities of measuring water flow in the primary circuit of the PWR and BWR units as well as in the BWR recirculation flow with the detection of N-16 activity induced in the core.

  4. Human response to vibroacoustic environments of space vehicles

    Science.gov (United States)

    Willshire, K. F.

    1984-01-01

    To insure efficient utilization of the system, space station design and operations will require special habitability considerations for the occupants and crew because of the relatively long duration missions. Of particular concern is the environment in which the personnel will live and work, and how it affects both the performance and comfort of the occupants. Current criteria do not consider possible effects of reduced gravity, long duration, and confinement. Preliminary to developing space station vibroacoustic habitability criteria, the adequacy of criteria for other space vehicles has been reviewed. In this paper, responses to the noise and vibration environments of both Skylab and Shuttle are discussed. Some astronauts have reported sleep interference, communication interference, distraction, and general annoyance as noise related complaints. In addition, information from the Russian Salyut missions, as well as similar based situtations (e.g., submarines), is reviewed.

  5. Effect of Stagger on the Vibroacoustic Loads from Clustered Rockets

    Science.gov (United States)

    Rojo, Raymundo; Tinney, Charles E.; Ruf, Joseph H.

    2016-01-01

    The effect of stagger startup on the vibro-acoustic loads that form during the end- effects-regime of clustered rockets is studied using both full-scale (hot-gas) and laboratory scale (cold gas) data. Both configurations comprise three nozzles with thrust optimized parabolic contours that undergo free shock separated flow and restricted shock separated flow as well as an end-effects regime prior to flowing full. Acoustic pressure waveforms recorded at the base of the nozzle clusters are analyzed using various statistical metrics as well as time-frequency analysis. The findings reveal a significant reduction in end- effects-regime loads when engine ignition is staggered. However, regardless of stagger, both the skewness and kurtosis of the acoustic pressure time derivative elevate to the same levels during the end-effects-regime event thereby demonstrating the intermittence and impulsiveness of the acoustic waveforms that form during engine startup.

  6. Establishment of Diagnostic Doses of Five Pyrethroids for Monitoring Physiological Resistance in Aedes Albopictus in Thailand.

    Science.gov (United States)

    Thanispong, Kanutcharee; Sathantriphop, Sunaiyana; Malaithong, Naritsara; Bangs, Michael J; Chareonviriyaphap, Theeraphap

    2015-12-01

    Monitoring insecticide resistance of Aedes albopictus is required for implementing effective dengue and chikungunya vector control in Thailand. The World Health Organization standard susceptibility test for adult mosquitoes was used to determine the baseline susceptibility of a pyrethroid-susceptible laboratory strain of Ae. albopictus to 5 different pyrethroids (deltamethrin, permethrin, bifenthrin, cypermethrin, and α-cypermethrin). Subsequently, the respective established diagnostic doses (0.026% deltamethrin, 1.024% permethrin, 0.570% bifenthrin, 0.237% cypermethrin, and 0.035% α-cypermethrin) were used to test field-collected Ae. albopictus from Rayong, Koh Chang, and Pong Nom Ron. As expected, the laboratory strain was completely susceptible to all pyrethroid insecticides at the established concentrations. Rayong mosquitoes were found to be highly susceptible to bifenthrin, cypermethrin, and α-cypermethrin. Koh Chang mosquitoes were susceptible to only deltamethrin and permethrin. Pong Nom Ron mosquitoes were resistant to all pyrethroids tested. Routine assessment of these baseline results should guide future resistance monitoring to pyrethroid insecticides in Ae. albopictus in Thailand.

  7. Can vibroacoustic stimulation improve the efficiency of a tertiary care antenatal testing unit?

    Science.gov (United States)

    Turitz, Amy L; Bastek, Jamie A; Sammel, Mary D; Parry, Samuel; Schwartz, Nadav

    2012-12-01

    Our primary objective was to determine whether vibroacoustic stimulation (VAS) decreases time to fetal reactivity in the antenatal testing unit (ATU) of a tertiary care center. We performed a prospective, quality assurance initiative to determine whether VAS could increase the efficiency of our ATU. On pre-specified "VAS days," VAS was applied for 3 s, if the non-stress test was non-reactive in the first 10 min. Generalized estimating equations models were used to account for within subject correlation due to multiple appointments per patient. VAS use was associated with a 3.76-min reduction in time to reactivity (21.79 vs 25.55, p = 0.011) and a 56% reduction in the need for a biophysical profile (OR: 0.44, 95% CI: 0.21-0.90). Overall, however, we found no significant decrease in time spent on the monitor or in the ATU. Compliance with a strict VAS protocol may improve the efficiency of increasingly busy ATUs.

  8. Fetal habituation to vibroacoustic stimulation in uncomplicated postterm pregnancies.

    Science.gov (United States)

    van Heteren, C F; Boekkooi, P F; Schiphorst, R H; Jongsma, H W; Nijhuis, J G

    2001-08-01

    Testing of fetal habituation to repeated vibroacoustic stimulation might give additional information concerning the fetal condition and central nervous system (CNS) functioning in postterm pregnancies. This study is designed to investigate whether healthy postterm fetuses are able to habituate and if so, if the habituation pattern of postterm fetuses differs from that of term fetuses. Twenty women with an uncomplicated pregnancy beyond 41 weeks gestational age (GA) participated, and 37 women with a GA between 37 and 40 weeks served as controls. The vibroacoustic stimulus was repeatedly applied to the maternal abdomen above the fetal legs for a period of 1s every 30s. A fetal trunk movement within 1s of stimulus application was considered a positive response. Lack of response to four consecutive stimuli indicated habituation. The habituation rate is defined as the number of stimuli applied before the fetus stopped responding. Data were compared using Mann-Whitney U test. Of the 18 postterm fetuses in which the presence or absence of habituation could be established, 14 habituated and four persisted in responding. Twenty-six of the 32 term fetuses, in which the presence or absence of habituation could be established, habituated and six persisted in responding. The habituation rate varied widely in postterm (median of eight stimuli, quartile ranges of 6 and 18) as well as in term fetuses (median of 9.5 stimuli, quartile ranges of 6 and 15). There was no difference in median habituation rate between postterm and term fetuses. The ongoing maturation of the CNS in the last weeks of pregnancy appears not to be reflected in the fetal habituation pattern. Furthermore, the interfetal variability in habituation of healthy postterm fetuses is such that testing of habituation appears not to be suitable for the identification of the fetus at risk for an adverse neonatal outcome.

  9. Vibro-acoustic performance of newly designed tram track structures

    Science.gov (United States)

    Haladin, Ivo; Lakušić, Stjepan; Ahac, Maja

    2017-09-01

    Rail vehicles in interaction with a railway structure induce vibrations that are propagating to surrounding structures and cause noise disturbance in the surrounding areas. Since tram tracks in urban areas often share the running surface with road vehicles one of top priorities is to achieve low maintenance and long lasting structure. Research conducted in scope of this paper gives an overview of newly designed tram track structures designated for use on Zagreb tram network and their performance in terms of noise and vibration mitigation. Research has been conducted on a 150 m long test section consisted of three tram track types: standard tram track structure commonly used on tram lines in Zagreb, optimized tram structure for better noise and vibration mitigation and a slab track with double sleepers embedded in a concrete slab, which presents an entirely new approach of tram track construction in Zagreb. Track has been instrumented with acceleration sensors, strain gauges and revision shafts for inspection. Relative deformations give an insight into track structure dynamic load distribution through the exploitation period. Further the paper describes vibro-acoustic measurements conducted at the test site. To evaluate the track performance from the vibro-acoustical standpoint, detailed analysis of track decay rate has been analysed. Opposed to measurement technique using impact hammer for track decay rate measurements, newly developed measuring technique using vehicle pass by vibrations as a source of excitation has been proposed and analysed. Paper gives overview of the method, it’s benefits compared to standard method of track decay rate measurements and method evaluation based on noise measurements of the vehicle pass by.

  10. A new molecular diagnostic tool for surveying and monitoring Triops cancriformis populations

    Directory of Open Access Journals (Sweden)

    Graham S. Sellers

    2017-05-01

    Full Text Available The tadpole shrimp, Triops cancriformis, is a freshwater crustacean listed as endangered in the UK and Europe living in ephemeral pools. Populations are threatened by habitat destruction due to land development for agriculture and increased urbanisation. Despite this, there is a lack of efficient methods for discovering and monitoring populations. Established macroinvertebrate monitoring methods, such as net sampling, are unsuitable given the organism’s life history, that include long lived diapausing eggs, benthic habits and ephemerally active populations. Conventional hatching methods, such as sediment incubation, are both time consuming and potentially confounded by bet-hedging hatching strategies of diapausing eggs. Here we develop a new molecular diagnostic method to detect viable egg banks of T. cancriformis, and compare its performance to two conventional monitoring methods involving diapausing egg hatching. We apply this method to a collection of pond sediments from the Wildfowl & Wetlands Trust Caerlaverock National Nature Reserve, which holds one of the two remaining British populations of T. cancriformis. DNA barcoding of isolated eggs, using newly designed species-specific primers for a large region of mtDNA, was used to estimate egg viability. These estimates were compared to those obtained by the conventional methods of sediment and isolation hatching. Our method outperformed the conventional methods, revealing six ponds holding viable T. cancriformis diapausing egg banks in Caerlaverock. Additionally, designed species-specific primers for a short region of mtDNA identified degraded, inviable eggs and were used to ascertain the levels of recent mortality within an egg bank. Together with efficient sugar flotation techniques to extract eggs from sediment samples, our molecular method proved to be a faster and more powerful alternative for assessing the viability and condition of T. cancriformis diapausing egg banks.

  11. Early evaluation of a second generation information monitoring and diagnostic system

    Energy Technology Data Exchange (ETDEWEB)

    Piette, Mary Ann; Kinney, Satkartar; Bourassa, Norman; Xu, Peng; Haves, Philip; Kinney, Kristopher; Shockman, Christine

    2002-03-25

    Private sector commercial office buildings are challenging environments for energy efficiency projects. This challenge is related to the complexity of business environments that involve ownership, operation, and tenant relationships. Whether it is poor quality design, inefficient operations, degradation of equipment over time, or merely the increasing use of energy by tenants and inattention from landlords, commercial office building energy use continues to increase. This research project was developed to examine the environment for building operations and identify causes of inefficient use of energy related to technical and organizational issues. This report discusses a second-generation Information Monitoring and Diagnostic System (IMDS) installed at a leased office building in Sacramento, California. The report begins with a brief summary of the IMDS research at the previous building, followed by a discussion of the building selection process, the IMDS design and installation, recent use of the IMDS, costs and benefits, and fault detection and diagnostic research using the IMDS. A web site describes the IMDS in detail (see imds.lbl.gov). The underlying principle of this research project is that high quality building performance data can help show where energy is being used and how buildings systems actually perform is an important first step toward improving building energy efficiency. The project utilizes a high-quality monitoring system that has been developed during the past decade by a partnership between LBNL and private industry. This research project has been successful in demonstrating that the IMDS is tremendously valuable to the building operators at the Sacramento site. The building operators not only accept the technology, but it has become the core of their day-to-day building control concepts. The innovative property management company, Jones Lang LaSalle, is interested in installing more sites to determine if the system could provide an economic

  12. The diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance?

    Science.gov (United States)

    Rossi, Esther Diana; Bizzarro, Tommaso; Longatto-Filho, Adhemar; Gerhard, Rene; Schmitt, Fernando

    2015-01-01

    Here, we evaluate the diagnostic and prognostic role of liquid-based cytology (LBC) in different body lesions, including thyroid, lung, effusions and malignant breast lesions. LBC has gained consensus after being applied to both non-gynecologic and fine-needle aspiration cytology. Although some remain sceptical regarding the diagnostic efficacy of LBC, mainly when used alone, in recent years, good results have been obtained as long as it showed a high diagnostic accuracy. Here, we discuss the additional possibility of storing material for the application of ancillary techniques (immunocytochemistry-molecular analysis) with several diagnostic and prognostic advantages, which may pave the way for the challenging evaluation of both monitoring responses to treatment and resistance to targeted therapies in thyroid, lung, breast carcinoma or malignant effusions. Furthermore, it provides the use of several molecular spots as specific targets for personalized therapy.

  13. Performance assessment and adoption processes of an information monitoring and diagnostic system prototype

    Energy Technology Data Exchange (ETDEWEB)

    Piette, Mary Ann

    1999-10-01

    This report addresses the problem that buildings do not perform as well as anticipated during design. We partnered with an innovative building operator to evaluate a prototype Information Monitoring and Diagnostic System (IMDS). The IMDS consists of high-quality measurements archived each minute, a data visualization tool, and a web-based capability. The operators recommend similar technology be adopted in other buildings. The IMDS has been used to identify and correct a series of control problems. It has also allowed the operators to make more effective use of the building control system, freeing up time to take care of other tenant needs. They believe they have significantly improved building comfort, potentially improving tenant health, and productivity. The reduction in hours to operate the building are worth about $20,000 per year, which could pay for the IMDS in about five years. A control system retrofit based on findings from the IMDS is expected to reduce energy use by 20 percent over the next year, worth over $30,000 per year. The main conclusion of the model-based chiller fault detection work is that steady-state models can be used as reference models to monitor chiller operation and detect faults. The ability of the IMDS to measure cooling load and chiller power to one-percent accuracy with a one-minute sampling interval permits detection of additional faults. Evolutionary programming techniques were also evaluated, showing promise in the detection of patterns in building data. We also evaluated two technology adoption processes, radical and routine. In routine adoption, managers enhance features of existing products that are already well understood. In radical adoption, innovative building managers introduce novel technology into their organizations without using the rigorous payback criteria used in routine innovations.

  14. Challenges to Providing a Successful Central Configuration Service to Support CERN’s New Controls Diagnostics and Monitoring System

    CERN Document Server

    Makonnen, Z; Zaharieva, Z

    2014-01-01

    The Controls Diagnostic and Monitoring service (DIAMON) provides monitoring and diagnostics tools to the operators in the CERN Control Centre. A recent reengineering presented the opportunity to restructure its data management and to integrate it with the central Controls Configuration Service (CCS). The CCS provides the Configuration Management for the Controls System for all accelerators at CERN. The new facility had to cater for the configuration management of all agents monitored by DIAMON, (>3000 computers of different types), provide deployment information, relations between metrics, and historical information. In addition, it had to be integrated into the operational CCS, while ensuring stability and data coherency. An important design decision was to largely reuse the existing infrastructure in the CCS and adapt the DIAMON data management to it e.g. by using the device/property model through a Virtual Devices framework to model the DIAMON agents. This article will show how these challenging requiremen...

  15. Polarization sensitive camera for the in vitro diagnostic and monitoring of dental erosion

    Science.gov (United States)

    Bossen, Anke; Rakhmatullina, Ekaterina; Lussi, Adrian; Meier, Christoph

    Due to a frequent consumption of acidic food and beverages, the prevalence of dental erosion increases worldwide. In an initial erosion stage, the hard dental tissue is softened due to acidic demineralization. As erosion progresses, a gradual tissue wear occurs resulting in thinning of the enamel. Complete loss of the enamel tissue can be observed in severe clinical cases. Therefore, it is essential to provide a diagnosis tool for an accurate detection and monitoring of dental erosion already at early stages. In this manuscript, we present the development of a polarization sensitive imaging camera for the visualization and quantification of dental erosion. The system consists of two CMOS cameras mounted on two sides of a polarizing beamsplitter. A horizontal linearly polarized light source is positioned orthogonal to the camera to ensure an incidence illumination and detection angles of 45°. The specular reflected light from the enamel surface is collected with an objective lens mounted on the beam splitter and divided into horizontal (H) and vertical (V) components on each associate camera. Images of non-eroded and eroded enamel surfaces at different erosion degrees were recorded and assessed with diagnostic software. The software was designed to generate and display two types of images: distribution of the reflection intensity (V) and a polarization ratio (H-V)/(H+V) throughout the analyzed tissue area. The measurements and visualization of these two optical parameters, i.e. specular reflection intensity and the polarization ratio, allowed detection and quantification of enamel erosion at early stages in vitro.

  16. Advancing Measurement Science to Assess Monitoring, Diagnostics, and Prognostics for Manufacturing Robotics.

    Science.gov (United States)

    Qiao, Guixiu; Weiss, Brian A

    2016-01-01

    Unexpected equipment downtime is a 'pain point' for manufacturers, especially in that this event usually translates to financial losses. To minimize this pain point, manufacturers are developing new health monitoring, diagnostic, prognostic, and maintenance (collectively known as prognostics and health management (PHM)) techniques to advance the state-of-the-art in their maintenance strategies. The manufacturing community has a wide-range of needs with respect to the advancement and integration of PHM technologies to enhance manufacturing robotic system capabilities. Numerous researchers, including personnel from the National Institute of Standards and Technology (NIST), have identified a broad landscape of barriers and challenges to advancing PHM technologies. One such challenge is the verification and validation of PHM technology through the development of performance metrics, test methods, reference datasets, and supporting tools. Besides documenting and presenting the research landscape, NIST personnel are actively researching PHM for robotics to promote the development of innovative sensing technology and prognostic decision algorithms and to produce a positional accuracy test method that emphasizes the identification of static and dynamic positional accuracy. The test method development will provide manufacturers with a methodology that will allow them to quickly assess the positional health of their robot systems along with supporting the verification and validation of PHM techniques for the robot system.

  17. Characterization and monitoring of host immune responses to infectious agents: what a future for microbiological diagnostics?

    Directory of Open Access Journals (Sweden)

    Riccardo Dolcetti

    2009-06-01

    Full Text Available Our knowledge on the mechanisms underlying microbial pathogenesis and host-microbe interactions has greatly improved over the last decade. In particular, the development of new and specific analytical methods has allowed the detailed characterization of innate and adaptive immune responses against clinically relevant microbial infections. Immunogenetic studies are continuously providing new insights on the genetic bases of individual differences in susceptibility to specific pathogens and most of the genetic markers identified so far include polymorphisms in genes controlling both innate and adaptive immune responses. Moreover, new standardized T cell assays allow reliable and reproducible evaluations of T cell phenotype and functions (i.e.: ELISPOT, including the identification of distinct functional signatures that are associated with the control of the infection.Although the number of these assays currently used in clinical practice is limited, a considerable increase is foreseen for the near future.This perspective constitutes an unprecedented opportunity for Clinical Microbiologists, who may now develop and apply integrated microbiologic/immunologic assays that may be useful for a more precise diagnostic definition and a more accurate clinical monitoring of the disease.

  18. Diagnostic Utility of Impedance-pH Monitoring in Refractory Non-erosive Reflux Disease.

    Science.gov (United States)

    Khan, Mohammed Q; Alaraj, Ali; Alsohaibani, Fahad; Al-Kahtani, Khalid; Jbarah, Sahar; Al-Ashgar, Hamad

    2014-10-30

    Approximately one-third of non-erosive reflux disease (NERD) patients are refractory to proton pump inhibitors (PPI) and face a therapeutic challenge. Therefore, it is important to differentiate between pathological and non-pathological reflux utilizing multichannel intraluminal impedance-pH (MII-pH) to analyze symptom-reflux association and diagnose true NERD versus hyper-sensitive esophagus (HE) and functional heartburn (FH). Herein, we evaluated the diagnostic yield of MII-pH in refractory NERD and sub-classified it based on quantity and quality of acid/non-acid reflux and reflux-symptom association. Sixty symptomatic NERD patients on twice daily PPI for > 2 months were prospectively evaluated by MII-pH. Distal and prox-imal refluxes, bolus exposure time (BET), esophageal acid exposure time, symptom index (SI) and symptom association proba-bility (SAP) were measured. Thirty-two (53%) patients had BET > 1.4% (MII-pH positive-true NERD), while 28 (47%) had BET 80% of symptoms were associated with non-acid reflux. The number of distal refluxes in true NERD versus FH or HE were significantly different, but not between FH and HE. Approximately 60% of refractory PPI NERD patients had positive reflux-symptom association, primarily due to non-acid reflux. Nearly half of NERD patients on PPI had normal MII-pH monitoring, sub-divided further into FH and HE equally.(J Neurogastroenterol Motil 2014;20:497-505).

  19. Vibroacoustic optimization of anti-tetrachiral and auxetic hexagonal sandwich panels with gradient geometry

    Science.gov (United States)

    Ranjbar, Mostafa; Boldrin, Luca; Scarpa, Fabrizio; Neild, Simon; Patsias, Sophoclis

    2016-05-01

    The work describes the vibroacoustic behavior of anti-tetrachiral and auxetic hexagonal gradient sandwich panels using homogenized finite element models to determine the mechanical properties of the auxetic structures, the natural frequencies and radiated sound power level of sandwich panels made by the auxetic cores. The mechanical properties and the vibroacoustic behavior of auxetic hexagonal sandwich panels are investigated as a benchmark. The radiated sound power level of the structure over the frequency range of 0-1000 Hz is minimized by modifying the core geometry of the gradient auxetic sandwich panels. Several excitation cases are considered. First-order and random optimization methods are used for the minimization of radiated sound power level of the structures. The results of this study present significant insights into the design of auxetic structures with respect to their vibroacoustical properties.

  20. Vibroacoustic disease: biological effects of infrasound and low-frequency noise explained by mechanotransduction cellular signalling.

    Science.gov (United States)

    Alves-Pereira, Mariana; Castelo Branco, Nuno A A

    2007-01-01

    At present, infrasound (0-20 Hz) and low-frequency noise (20-500 Hz) (ILFN, 0-500 Hz) are agents of disease that go unchecked. Vibroacoustic disease (VAD) is a whole-body pathology that develops in individuals excessively exposed to ILFN. VAD has been diagnosed within several professional groups employed within the aeronautical industry, and in other heavy industries. However, given the ubiquitous nature of ILFN and the absence of legislation concerning ILFN, VAD is increasingly being diagnosed among members of the general population, including children. VAD is associated with the abnormal growth of extra-cellular matrices (collagen and elastin), in the absence of an inflammatory process. In VAD, the end-product of collagen and elastin growth is reinforcement of structural integrity. This is seen in blood vessels, cardiac structures, trachea, lung, and kidney of both VAD patients and ILFN-exposed animals. VAD is, essentially, a mechanotransduction disease. Inter- and intra-cellular communication is achieved through both biochemical and mechanotranduction signalling. When the structural components of tissue are altered, as is seen in ILFN-exposed specimens, the mechanically mediated signalling is, at best, impaired. Common medical diagnostic tests, such as EKG, EEG, as well as many blood chemistry analyses, are based on the mal-function of biochemical signalling processes. VAD patients typically present normal values for these tests. However, when echocardiography, brain MRI or histological studies are performed, where structural changes can be identified, all consistently show significant changes in VAD patients and ILFN-exposed animals. Frequency-specific effects are not yet known, valid dose-responses have been difficult to identify, and large-scale epidemiological studies are still lacking.

  1. Vibroacoustic payload environment prediction system (VAPEPS): Data base management center remote access guide

    Science.gov (United States)

    Thomas, V. C.

    1986-01-01

    A Vibroacoustic Data Base Management Center has been established at the Jet Propulsion Laboratory (JPL). The center utilizes the Vibroacoustic Payload Environment Prediction System (VAPEPS) software package to manage a data base of shuttle and expendable launch vehicle flight and ground test data. Remote terminal access over telephone lines to a dedicated VAPEPS computer system has been established to provide the payload community a convenient means of querying the global VAPEPS data base. This guide describes the functions of the JPL Data Base Management Center and contains instructions for utilizing the resources of the center.

  2. Improvement of vibroacoustic properties of toothed gears through constructional modifications of gear teeth

    Directory of Open Access Journals (Sweden)

    Andrzej WIECZOREK

    2009-01-01

    Full Text Available The paper draws attention to methods of minimizing values of vibroacoustic factors by reducing the sources. In the case of toothed gears such causes include, first of all, deviations in workmanship, excitations generated when teeth move in and out of mesh, as well as mesh stiffness variations. The paper presents results of experimental research on vibroacoustic properties of gear wheels with modified and non-modified high-profile teeth. Basing on these results, it was determined that the best results in counteracting vibrations and noise are obtained by using jointly an increased gear contact ratio and a tooth profile modification.

  3. Using the Saturn V and Titan III Vibroacoustic Databanks for Random Vibration Criteria Development

    Science.gov (United States)

    Ferbee, R C.

    2009-01-01

    This is an update to TN D-7159, "Development and Application of Vibroacoustic Structural Data Banks in Predicting Vibration Design and Test Criteria for Rocket Vehicle Structures", which was originally published in 1973. Errors in the original document have been corrected and additional data from the Titan III program have been included. Methods for using the vibroacoustic databanks for vibration test criteria development are shown, as well as all of the data with drawings and pictures of the measurement locations. An Excel spreadsheet with the data included is available from the author.

  4. Development of a vibroacoustic data base management and prediction system for payloads

    Science.gov (United States)

    On, F. J.; Hendricks, W.

    1982-01-01

    A data base management and prediction system called vibroacoustic payload environment prediction system (VAPEPS) was developed to serve as a repository for shuttle or extendable booster payload component flight and ground test data. This system is to be made available to the aerospace community for multiple uses including that of establishing the vibroacoustic environment for new payload components. The VAPEPS data includes that spectral information normally processed from vibration and acoustic measurements (e.g., power spectra, sound pressure level spectra, etc.). Results of development to provide this capability by NASA Goddard Space Flight Center and Lockheed Missiles and Space Company are described.

  5. Predicting the vibroacoustic response of satellite equipment panels.

    Science.gov (United States)

    Conlon, S C; Hambric, S A

    2003-03-01

    Modern satellites are constructed of large, lightweight equipment panels that are strongly excited by acoustic pressures during launch. During design, performing vibroacoustic analyses to evaluate and ensure the integrity of the complex electronics mounted on the panels is critical. In this study the attached equipment is explicitly addressed and how its properties affect the panel responses is characterized. FEA and BEA methods are used to derive realistic parameters to input to a SEA hybrid model of a panel with multiple attachments. Specifically, conductance/modal density and radiation efficiency for nonhomogeneous panel structures with and without mass loading are computed. The validity of using the spatially averaged conductance of panels with irregular features for deriving the structure modal density is demonstrated. Maidanik's proposed method of modifying the traditional SEA input power is implemented, illustrating the importance of accounting for system internal couplings when calculating the external input power. The predictions using the SEA hybrid model agree with the measured data trends, and are found to be most sensitive to the assumed dynamic mass ratio (attachments/structure) and the attachment internal loss factor. Additional experimental and analytical investigations are recommended to better characterize dynamic masses, modal densities and loss factors.

  6. Voice acoustic patterns of patients diagnosed with vibroacoustic disease.

    Science.gov (United States)

    Mendes, Ana; Alves-Pereira, Mariana; Castelo Branco, Nuno A A

    2006-01-01

    Long-term low frequency noise exposure (LFN) (vibroacoustic disease (VAD), a systemic pathology characterized by the abnormal growth of extra-cellular matrices. The respiratory system is a target for LFN. Fibrosis of the respiratory tract epithelia was observed in VAD patients through biopsy, and confirmed in animal models exposed to LFN. Voice acoustic analysis can detect vocal fold variations of mass, tension, muscular and neural activity. Frequency perturbation (jitter), amplitude perturbation (shimmer) and harmonic-to-noise ratio (HNR) are used in the evaluation of the vocal function, and can be indicators of the presence and degree of severity of vocal pathology. Since the respiratory system is the energy source of the phonation process, this raises questions about the effects of VAD on voice production. The purpose of this study was to determine if voice acoustic parameters of VAD patients are different from normative data. Nine individuals (5 males and 4 females) diagnosed with VAD were recorded performing spoken and sung tasks. The spoken tasks included sustaining vowels and fricatives. The sung tasks consisted of maximum phonational frequency range (MPFR). Voice acoustic parameters ana- lysed were: fundamental frequency (F0), jitter, shimmer, HNR and temporal measures. Compared with normative data, both males and females diagnosed with VAD exhibited increased F0, shimmer and HNR. Jitter, MPFR and one temporal measure were reduced. VAD individuals presented voice acoustic parameter differences in spectral, temporal and perturbation measures, which may be indicative of small morphological changes in the phonatory system.

  7. The palmo-mental reflex in vibroacoustic disease.

    Science.gov (United States)

    Martinho Pimenta, A J; Castelo Branco, M S; Castelo Branco, N A

    1999-03-01

    Vibroacoustic disease (VAD), is a multisystemic nosological entity, caused by occupational exposure to large pressure amplitude (> or = 90 dB SPL) and low frequency (< or = 500 Hz) (LPALF) noise. The most common neurological finding in patients with VAD is the palmomental reflex (PMR). The aim of this study is to evaluate the frequency and characteristics of this primitive reflex in a population of VAD patients. Sixty individuals, occupationally exposed to LPALF noise underwent a neurological examination. In each one, unilateral contraction of the chin muscles was triggered through the stimulation of the thenar eminence. When a response habituation was observed, or when there was no response except previously existing skin retraction and small dimples, an EMG was performed. All these subjects also received brain MRI and measurement of endogenous evoked potentials. Thirty individuals presented unilateral or bilateral PMR; 26 of these presented changes in the brain MRI. EMG measurement evidenced continuous contraction of the chin muscles, without visible PMR, triggered by the stimulation of the thenar eminence. PMR is present in 50% of the patients with VAD. In the VAD patients, the frequency of abnormal chin muscle activity is higher than the frequency of PMR and represents a loss of the cortical control over the brainstem structures.

  8. Vibroacoustic Response Data of Stiffened Panels and Cylinders

    Science.gov (United States)

    Cabell, Randolph; Klos, Jake; Buehrle, Ralph; Schiller, Noah

    2008-01-01

    NASA has collected vibroacoustic response data on a variety of complex, aerospace structures to support research into numerical modeling of such structures. This data is being made available to the modeling community to promote the development and validation of analysis methods for these types of structures. Existing data from two structures is described, as well as plans for a data set from a third structure. The first structure is a 1.22 m by 1.22 m stiffened aluminum panel, typical of a commercial aircraft sidewall section. The second is an enclosed, stiffened aluminum cylinder, approximately 3.66 m long and 1.22 m in diameter, constructed to resemble a small aircraft fuselage with no windows and a periodic structure. The third structure is a filament-wound composite cylinder with composite stiffeners. Numerous combinations of excitation and response variables were measured on the structures, including: shaker excitation; diffuse acoustic field; velocity response from a laser vibrometer; intensity scans; and point acceleration.

  9. Fetal brain activity and hemodynamic response to a vibroacoustic stimulus.

    Science.gov (United States)

    Fulford, Jonathan; Vadeyar, Shantala H; Dodampahala, Sanani H; Ong, Stephen; Moore, Rachel J; Baker, Philip N; James, David K; Gowland, Penny

    2004-06-01

    Previous studies have demonstrated the practicality of using functional magnetic resonance imaging (fMRI) techniques to assess fetal brain activity. The purpose of this study was to compare the fetal hemodynamic response to that of the adult. Seventeen pregnant subjects, all of whom were at more than 36 weeks gestation were scanned while the fetus was exposed to a vibroacoustic stimulus. Thirteen adult subjects were scanned with an equivalent acoustic stimulus. Of the fetal subjects, two could not be analyzed due to technical problems, eight did not show significant activation, and seven showed significant activation. In all cases, activation was localized within the temporal region. Measures of fetal hemodynamic responses revealed an average time to peak (ttp) of 7.36 +/- 0.94 sec and an average percentage change of 2.67 +/- 0.93%. In contrast, activation was detected in 5 of 13 adults with an average ttp of 6.54 +/- 0.54 sec and an average percentage change of 1.02 +/- 0.40%. The measurement of changes in the fetal hemodynamic response may be important in assessing compromised pregnancies. Copyright 2004 Wiley-Liss, Inc.

  10. Epilepsy in the vibroacoustic disease: a case report.

    Science.gov (United States)

    Martinho Pimenta, A J; Castelo Branco, N A

    1999-03-01

    Late-onset epilepsy was one of the first neurological problems identified in patients diagnosed with vibroacoustic disease. Other clinical situations, such as automatisms and rage-like reaction crises were also observed. Some cases of epileptic seizures were triggered by different types of stimuli. This study describes the clinical case of a 30-yr-old male metal-worker who had epileptic seizures when he used vibratory tools common to his profession, such as drills and sanders. We performed a 21-channel EEG during a seizure induced in the laboratory by direct contact of a vibratory tool with his right hand. This allowed us to view the electrical discharge of his left hemisphere. The entire procedure was simultaneously videotaped while a partial motor crisis was observed. Brain MRI of this subject revealed multiple hyperintense focal lesions in the sub-cortical white matter. Echocardiography revealed thickening of the pericardium and valve structures. To the authors' knowledge, this is the first documented case of reflex epilepsy due to vibratory stimuli. We briefly discuss the possible pathophysiological mechanisms of this clinical event.

  11. Involvement of central airways in vibroacoustic disease patients.

    Science.gov (United States)

    Ferreira, José Reis; Monteiro, Miguel B; Tavares, Fernanda; Serrano, Isabel; Monteiro, Emanuel; Mendes, Carla P; Alves-Pereira, Mariana; Branco, Nuno A A Castelo

    2006-01-01

    Vibroacoustic disease (VAD) is the whole-body pathology caused by excessive exposure to LFN. For the past 25 years, it has been know that low frequency noise (LFN, < 500 Hz, including infrasound) targets the respiratory system. In LFN-exposed rodents, the morphological changes of respiratory tract tissue partially explained some respiratory symptoms reported by VAD patients. However, many questions remain unanswered. Recently, some volunteer VAD patients underwent bronchoscopy in order to ascertain possible damage that could be associated with their respiratory complaints. Fourteen fully-informed and volunteer VAD patients were submitted to bronchoscopy, and biopsies were removed for analysis. All patients exhibited small submucosal vascular-like lesions near the spurs, consisting of increased collagen and elastin fibres. Histology disclosed cilliary abnormalities, basal membrane hyperplasia, and thickening of vessel walls. In five patients, collagen bundles appeared degenerative and disrupted. No inflammatory process was ever identified, and no differences were seen between smokers and non-smokers. Data is in accordance with what was observed in LFN-exposed animal models and also in 8 VAD patients who developed lung tumours. Collagen disruption and degeneration was also observed in electron microscopy images of the respiratory tract of LFN-exposed rodents. Thickened blood and lymphatic vessel walls have been consistently seen in images of VAD patients and of LFN-exposed rodents. During bronchoscopy performed by other reasons, this sort of structural aspects is not frequently seen. Taken together, it is strongly suggested that these findings could be VAD-specific.

  12. Decentralized diagnostics based on a distributed micro-genetic algorithm for transducer networks monitoring large experimental systems

    Science.gov (United States)

    Arpaia, P.; Cimmino, P.; Girone, M.; Commara, G. La; Maisto, D.; Manna, C.; Pezzetti, M.

    2014-09-01

    Evolutionary approach to centralized multiple-faults diagnostics is extended to distributed transducer networks monitoring large experimental systems. Given a set of anomalies detected by the transducers, each instance of the multiple-fault problem is formulated as several parallel communicating sub-tasks running on different transducers, and thus solved one-by-one on spatially separated parallel processes. A micro-genetic algorithm merges evaluation time efficiency, arising from a small-size population distributed on parallel-synchronized processors, with the effectiveness of centralized evolutionary techniques due to optimal mix of exploitation and exploration. In this way, holistic view and effectiveness advantages of evolutionary global diagnostics are combined with reliability and efficiency benefits of distributed parallel architectures. The proposed approach was validated both (i) by simulation at CERN, on a case study of a cold box for enhancing the cryogeny diagnostics of the Large Hadron Collider, and (ii) by experiments, under the framework of the industrial research project MONDIEVOB (Building Remote Monitoring and Evolutionary Diagnostics), co-funded by EU and the company Del Bo srl, Napoli, Italy.

  13. Implementation of the quality control of diagnostic monitors; Puesta en marcha del control de calidad de monitores de diagnostico

    Energy Technology Data Exchange (ETDEWEB)

    Ramos Pacho, J. A.; Gomez Llorente, P. L.; Gomez Llorente, N.; Cons Perez, N.; Verde Velasco, J. M.; Perez Alvarez, M. E.; Delgado Aparicio, J. M.; Garcia Repiso, S.; Montes Fuentes, C.; Martin Rincon, C.

    2013-07-01

    The optimization of the quality of Radiology is aimed at obtaining greater diagnostic information minimizing the risks to the patient. This is essential, among other factors, not only that the image acquisition system works properly, but that the display device is capable of representing the information contained. (Author)

  14. The responses to repeated vibroacoustic stimulation in a fetus with trisomy 18.

    Science.gov (United States)

    van Heteren, C F; Focco Boekkooi, P; Jongsma, H W; Nijhuis, J G

    2001-05-01

    Observation of the fetal movement and fetal heart rate responses to repeated vibroacoustic stimulation might be useful as a measure to assess fetal well-being. Studies of abnormal fetuses are needed to gain insight in the spectrum of possible responses to stimulation. We present a case of a fetus with trisomy 18 that failed to respond to repeated stimulation.

  15. [Vibroacoustic factors hygienic regulation principles in Russia and abroad evolution and succession].

    Science.gov (United States)

    Prokopenko, L V; Kravchenko, O K; Ermolenko, A E; Kurierov, N N; Lagutina, A V; Tseitlina, G S

    2013-01-01

    Brief historical summary about Institute' vibroacoustic factors investigations development in the XXth century is presented. There are shown the data of noise, vibration, ultra- and infrasound hygienic rating in comparison with international approaches; the ways of its international harmonization in modern social and economic situation are selected.

  16. Utilization of old vibro-acoustic measuring equipment to grasp basic concepts of vibration measurements

    DEFF Research Database (Denmark)

    Darula, Radoslav

    2013-01-01

    The aim of the paper is to show that even old vibro-acoustic (analog) equipment can be used as a very suitable teaching equipment to grasp basic principles of measurements in an era, when measurement equipments are more-or-less treated as ‘black-boxes’, i.e. the user cannot see directly how...

  17. Joint motion quality in vibroacoustic signal analysis for patients with patellofemoral joint disorders.

    Science.gov (United States)

    Bączkowicz, Dawid; Majorczyk, Edyta

    2014-12-12

    Chondromalacia, lateral patellar compression syndrome and osteoarthritis are common patellofemoral joint disorders leading to functional and/or structural disturbances in articular surfaces. The objective of the study was to evaluate their impact on joint motion quality via the vibroacoustic signal generated during joint movement analysis. Seventy-three patients (30 with chondromalacia, 21 with lateral patellar compression syndrome, and 22 with osteoarthritis) and 32 healthy controls were tested during flexion/extension knee motion for vibroacoustic signals using an acceleration sensor. Estimated parameters: variation of mean square (VMS), difference between mean of four maximum and mean of four minimum values (R4), power spectral density for frequency of 50-250 Hz (P1) and 250-450 Hz (P2) were analyzed. Vibroacoustic signals recorded for particular disorders were characterized by significantly higher values of parameters in comparison to the control group. Moreover, differences were found among the various types of patellofemoral joint disturbances. Chondromalacia and osteoarthritis groups showed differences in all parameters examined. In addition, osteoarthritis patients exhibited differences in VMS, P1 and P2 values in comparison to lateral patellar compression syndrome patients. However, only the value of R4 was found to differ between knees with lateral patellar compression syndrome and those with chondromalacia. Our results suggest that particular disorders are characterized by specific vibroacoustic patterns of waveforms as well as values of analyzed parameters.

  18. The effect of antenatal steroid administration on the fetal response to vibroacoustic stimulation.

    Science.gov (United States)

    Rotmensch, S; Celentano, C; Liberati, M; Sadan, O; Glezerman, M

    1999-11-01

    Betamethasone transiently suppresses multiple fetal biophysical activities, including breathing movements, limb and trunk movements, heart rate variability, and heart rate accelerations. Unnecessary iatrogenic delivery of preterm fetuses due to the false diagnosis of fetal compromise has been described in this setting. The sonographically observed startle response of the fetus to vibroacoustic stimulation has been described as another modality to provide reassurance about fetal well-being. It is unknown, however, whether the startle response is also suppressed by betamethasone. The purpose of this study was to examine the effect of betamethasone on this biophysical parameter. A prospective cohort study. Vibroacoustic stimulation was applied to the maternal abdomen and fetal movement responses were sonographically observed prior to (0 hours), 48 hours after, and 96 hours after betamethasone administration. We recorded the presence or absence of the fetal startle response, and, if a response was present, graded semi-quantitatively the intensity of the movements (vigorous versus sluggish). Twenty-two of 26 fetuses (84.6%) displayed a vigorous vibroacoustic startle response prior to betamethasone administration, in comparison to three of 26 fetuses (11.5%) at 48 hours after exposure (pvibroacoustic stimulation. Accordingly, this modality cannot be used for the ascertainment of fetal well-being of steroid exposed fetuses. Betamethasone seems to suppress central nervous system dependent biophysical activities. including the brain-stem dependent vibroacoustic startle reflex.

  19. Vibroacoustic Response of Residential Housing due to Sonic Boom Exposure: A Summary of two Field Tests

    Science.gov (United States)

    Klos, Jacob; Buehrle, Ralph; Sullivan, Brenda; Gavin, Joseph; Salamone, Joseph; Haering, Edward A., jr.; Miller, Denise M.

    2008-01-01

    Two experiments have been performed to measure the vibroacoustic response of houses exposed to sonic booms. In 2006, an old home in the base housing area of Edwards Air Force Base, built around 1960 and demolished in 2007, was instrumented with 288 transducers. During a 2007 follow-on test, a newer home in the base housing area, built in 1997, was instrumented with 112 transducers. For each experiment, accelerometers were placed on walls, windows and ceilings in bedrooms of the house to measure the vibration response of the structure. Microphones were placed outside and inside the house to measure the excitation field and resulting interior sound field. The vibroacoustic response of each house was measured for sonic boom amplitudes spanning from 2.4 to 96 Pa (0.05 to 2 lbf/sq ft). The boom amplitudes were systematically varied using a unique dive maneuver of an F/A-18 airplane. In total, the database for both houses contains vibroacoustic response data for 154 sonic booms. In addition, several tests were performed with mechanical shaker excitation of the structure to characterize the forced response of the houses. The purpose of this paper is to summarize all the data from these experiments that are available to the research community, and to compare and contrast the vibroacoustic behavior of these two dissimilar houses.

  20. Vibro-Acoustic modulation based damage identification in a composite skin-stiffener structure

    NARCIS (Netherlands)

    Ooijevaar, T.H.; Loendersloot, Richard; Rogge, M.D.; Akkerman, Remko; Tinga, Tiedo; Le Cam, V.; Mevel, L.; Schoefs, F.

    2014-01-01

    The vibro-acoustic modulation method is applied to a composite skin-stiffener structure to investigate the possibilities to utilise this method for damage identification in terms of detection, localisation and damage quantification. The research comprises a theoretical part and an experimental part.

  1. Vibro-Acoustic Numerical Analysis for the Chain Cover of a Car Engine

    National Research Council Canada - National Science Library

    Enrico Armentani; Raffaele Sepe; Antonio Parente; Mauro Pirelli

    2017-01-01

    In this work, a vibro-acoustic numerical and experimental analysis was carried out for the chain cover of a low powered four-cylinder four-stroke diesel engine, belonging to the FPT (FCA Power Train) family called SDE (Small Diesel Engine...

  2. Development of Monitoring and Diagnostic Methods for Robots Used In Remediation of Waste Sites - Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Martin, M.

    2000-04-01

    This project is the first evaluation of model-based diagnostics to hydraulic robot systems. A greater understanding of fault detection for hydraulic robots has been gained, and a new theoretical fault detection model developed and evaluated.

  3. Respiratory pathology in vibroacoustic disease: 25 years of research.

    Science.gov (United States)

    Branco, Nuno A A Castelo; Ferreira, José Reis; Alves-Pereira, Mariana

    2007-01-01

    Respiratory pathology induced by low frequency noise (LFN, vibroacoustic disease (VAD), a whole-body pathology caused by excessive exposure to LFN, respiratory pathology takes on specific features. Initially, respiratory pathology was not considered a con- sequence of LFN exposure; but today, LFN can be regarded as a major agent of disease that targets the respiratory system. The goal of this report is to put forth what is known to date on the clinical signs of respiratory pathology seen in VAD patients. Data from the past 25 years of research will be taken together and presented. In persons exposed to LFN on the job, respiratory complaints appear af- ter the first 4 years of professional activity. At this stage, they disappear during vacation periods or when the person is removed form his /her workstation for other reasons. With long-term exposure, more serious situations can arise, such as, atypical pleural effusion, respiratory insufficiency, fibrosis and tumours. There is no correlation with smoking habits. In LFN-exposed animal models, morphological changes of the pleura, and loss of the phagocytic ability of pleural mesothelial cells (explaining the atypical pleural effusions). Fibrotic lesions and neo-vascularization were observed along the entire respiratory tract. Fibrosis lesions and neovascularisation were observed through- out the respiratory tract of the animals seen. Pre-malignant lesions, metaplasia e displasia, were also identified. LFN is an agent of disease and the respiratory tract is one of its preferential targets. The respiratory pathology associated with VAD needs further in-depth studies in order to achieve a greater understanding, and develop methods of pharmaco- logical intervention.

  4. Vibroacoustic stimulation enhances visualization of the four-chamber cardiac view in the third trimester.

    Science.gov (United States)

    Lazebnik, N; Hill, L M; Costantino, J P; Many, A; Martin, J G

    1996-11-01

    The objective of this study was to determine whether vibroacoustic stimulation would improve the visualization rate of the four-chamber cardiac view. Patients between 26 and 42 weeks' gestation were considered to be candidates for this study if the amniotic fluid index (AFI) was between 8.0 and 24.0 cm, no malformations were detected on a careful fetal anatomical survey and a four-chamber cardiac view was not obtainable. Once a four-chamber view was considered to be not obtainable due to fetal position, the patient was asked to withdraw a sealed envelope and was assigned to either the study or the control group. The 164 study patients received one to three 3-s vibroacoustic stimulations. Five minutes later a second attempt was made to visualize the four-chamber view adequately. The control group consisted of another 198 subjects in whom a four-chamber view could not be obtained. The control group did not receive vibroacoustic stimulation. A similar 5-min time interval was allowed to elapse before an attempt was made to visualize the four-chamber view. The study and control groups were similar with respect to fetal presentation, placental location, fetal weight category, biophysical profile score, gestational age, AFI and estimated fetal weight. The rate of the four-chamber view was significantly higher among fetuses receiving vibroacoustic stimulation (20.1%), in comparison to the control group (11.1%) (p = 0.019). Successful repositioning was more likely among fetuses with estimated fetal weight between 2251 and 3050 g, and at a gestational age between 33.1 and 37.0 weeks. We conclude that in a selected group of patients vibroacoustic stimulation can be used to enhance visualization of the four-chamber view.

  5. Comparison of halogen light and vibroacoustic stimulation on nonreactive fetal heart rate pattern.

    Science.gov (United States)

    Rahimikian, Fatemeh; Rahiminia, Tahereh; Modarres, Maryam; Mehran, Abbas

    2013-03-01

    One of the first-line assessment tools for fetal surveillance is nonstress test (NST), although it is limited by a high rate of false-nonreactive results. This study was performed to investigate if external stimulation from vibroacoustic and halogen light could help in provoking fetal responsiveness and altering NST results. This is a clinical trial. Sampling was done from April to July 2010. One hundred pregnant women with nonreactive NST for 20 min were allocated in two groups: Vibroacoustic stimulated NST (VNST, n = 50) who received vibration from a standard fetal vibratory stimulator and halogen light stimulated NST (LNST, n = 50) who received a halogen light source for 3 and 10 sec, respectively. Results were compared together and then compared to biophysical profile (BPP) scores as a backup test. We used Mann-Whitney U test, Chi-square test, and Fisher's exact test to compare the variables in the two groups through SPSS version 14. P vibroacoustic stimulation group changed to reactive patterns. Time to onset of the first acceleration (VNST: 2.17 min; LNST: 2.27 min) and the test duration (VNST: 4.91 min; LNST: 5.26 min) were the same in the two groups. In VNST 89.5% and in LNST 87.5% of nonreactivity followed by score 8 in BPP. There was no significant relation between stimulus NSTs and BPPs. Vibroacoustic and light stimulation offer benefits by decreasing the incidence of nonreactive results and reducing the test time. Both halogen light stimulation and vibroacoustic stimulation are safe and efficient in fetal well-being assessment services.

  6. How the factoid of wind turbines causing ‘vibroacoustic disease’ came to be ‘irrefutably demonstrated’

    National Research Council Canada - National Science Library

    Chapman, Simon; St George, Alexis

    2013-01-01

    ... of these, “vibroacoustic disease” (VAD) is frequently mentioned. The aim of this study is to examine the quality of the evidence on how VAD came to be associated with wind turbine exposure by wind farm opponents. Methods...

  7. Use of acoustic emission for continuous monitoring of steam generators. Die Nutzung der Schallemission zur kontinuierlichen Betriebsueberwachung des Dampferzeugers

    Energy Technology Data Exchange (ETDEWEB)

    Crha, J.; Silny, A.; Mezanec, K. (Eisenforschungsinstitut, Ostrava-Vitkovice (Czechoslovakia))

    1990-11-01

    Acoustic emission measurements at nuclear power plant components are presented and discussed. The knowledge gained by registering acoustic emission during the studied periods of time has shown the main direction for further application in nuclear energy. In the first place it will be necessary to perform detailed investigations into the influence of the operating technology in the frequency ranges used. Calculations are made on the basis of the reciprocal correlations of vibroacoustic and acoustic emission measurements performed by multichannel measuring systems. The shifting of diagnostic measurements to the range of over 100 kHz is proof of new applications of acoustic emission analysis (indication of outflow). Furthermore, the necessity of continuously monitoring the construction was confirmed by experiences gained from laboratory measurements. Damages occur according to a step mechanism. For this reason, no pressure test can replace continuous measuring. (orig.).

  8. Developing an automated database for monitoring ultrasound- and computed tomography-guided procedure complications and diagnostic yield.

    Science.gov (United States)

    Itri, Jason N; Jones, Lisa P; Kim, Woojin; Boonn, William W; Kolansky, Ana S; Hilton, Susan; Zafar, Hanna M

    2014-04-01

    Monitoring complications and diagnostic yield for image-guided procedures is an important component of maintaining high quality patient care promoted by professional societies in radiology and accreditation organizations such as the American College of Radiology (ACR) and Joint Commission. These outcome metrics can be used as part of a comprehensive quality assurance/quality improvement program to reduce variation in clinical practice, provide opportunities to engage in practice quality improvement, and contribute to developing national benchmarks and standards. The purpose of this article is to describe the development and successful implementation of an automated web-based software application to monitor procedural outcomes for US- and CT-guided procedures in an academic radiology department. The open source tools PHP: Hypertext Preprocessor (PHP) and MySQL were used to extract relevant procedural information from the Radiology Information System (RIS), auto-populate the procedure log database, and develop a user interface that generates real-time reports of complication rates and diagnostic yield by site and by operator. Utilizing structured radiology report templates resulted in significantly improved accuracy of information auto-populated from radiology reports, as well as greater compliance with manual data entry. An automated web-based procedure log database is an effective tool to reliably track complication rates and diagnostic yield for US- and CT-guided procedures performed in a radiology department.

  9. State-of-health monitoring of 18650 4S packs with a single-point impedance diagnostic

    Science.gov (United States)

    Love, Corey T.; Virji, Maheboob B. V.; Rocheleau, Richard E.; Swider-Lyons, Karen E.

    2014-11-01

    The state-of-health (SOH) of Li-ion batteries and battery packs must be monitored effectively for abuse to prevent failure and accidents. In a previous publication, we described a single-point impedance diagnostic method for detecting damage in single prismatic lithium polymer rechargeable cells subjected to overcharge abuse. We now determine whether the single-point impedance diagnostic method is applicable to 4S battery packs. At 316 Hz, commercial 18650 LiCoO2 cells are determined to have the least change in impedance response when cycled between 3.0 and 4.2 V, for states-of-charge (SOC) of 0-100%. The impedance response of single cells at 316 Hz changes dramatically during overcharge (SOC = 125%), presumably due to change in their solid electrolyte interface (SEI) layers at the electrodes. When a single cell is purposely subjected to such overcharge abuse and then integrated into a 4S pack with 3 other healthy cells, the impedance response of the 4S pack at 316 Hz also changes, despite variances in the impedance response of each of the 3 healthy cells. The results suggest that this single-point impedance method could serve as a diagnostic in an all-inclusive battery management system to identify overcharge abuse of single cells without individual cell monitoring.

  10. The use of diagnostic ratios, biomarkers and 3-way Kohonen neural networks to monitor the temporal evolution of oil spills.

    Science.gov (United States)

    Fernández-Varela, R; Gómez-Carracedo, M P; Ballabio, D; Andrade, J M

    2015-07-15

    Oil spill identification relies usually on a wealth of chromatographic data which requires advanced data treatment (chemometrics). A simple approach based on Kohonen neural networks to handle three-dimensional arrays is presented. A suite of 28 diagnostic ratios was considered to monitor six oils along four months. It was found that some traditional diagnostic ratios were not stable enough. In particular, alkylated PAHs (e.g. 1-methyldibenzothiophene, 4-methylpyrene, 27bbSTER and the TA21 and TA26 triaromatic steroids) seemed less resistant to medium-weathering than biomarkers. One (or two) ratios were found to differentiate each product: 30O, 28ab (and 25nor30ab), C3-dbt/C3-phe, 27Ts, TA26 and 29Ts characterized Ashtart, Brent, Maya, Sahara, IFO and Prestige oils, respectively. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Comparison of 3MP medical-grade to 1MP office-grade LCD monitors in mammographic diagnostic and perceptual performance.

    Science.gov (United States)

    Ong, Aaron H J; Pitman, Alexander G; Tan, Shu Yi; Gledhill, Samuel; Hennessy, Oliver; Lui, Belinda; Lemish, Wayne; Tauro, Paul; Styles, Colin; Pun, Emma; Waugh, John; Padmanabhan, Meenakshi; Lee, Allan

    2011-04-01

    Picture archiving and communication systems images designed to be viewed on high-resolution medical-grade monitors are routinely viewed on office-grade monitors on the wards or at home. This study aimed to determine whether a statistically significant difference in diagnostic (cancer detection) and perceptual (microcalcification detection) performance exists between 3MP grade and 1MP office-grade monitors. 3MP Dome medical-grade liquid crystal display (LCD) monitors (Planar, Beaverton, OR, USA) were compared to 1MP Dell office-grade LCD monitors (Dell Inc, Round Rock, TX, USA). Eight radiologists (reader experience 8-30 years) read the same set of 100 mammograms (23/100 with proven cancers and 52/100 with microcalcifications) presented in random order on three occasions separated by two time intervals of 12 weeks. Reads 1 and 3 utilised 3MP monitors and formed the baseline read. Read 2 utilised 1MP monitors and constituted the experimental read. Reading conditions were standardised. Readers were aware of which monitors they were using. Multivariate logistic regression analysis (to account for reader variability and monitor impact) was performed to assess for statistical significance. At α = 5%, confidence intervals analysis comparing the measured parameters between 1MP to 3MP monitors demonstrated no statistically significant difference in diagnostic and perceptual performance for the reader group. In cancer detection (the diagnostic task), reader accuracy remained high irrespective of monitor type. Regression analysis comparing performance with 1MP against 3MP monitors found P values of 0.693 and 0.324 for diagnostic and perceptual performance, respectively. There were no statistically and clinically significant differences between 3MP and 1MP monitors in mammographic diagnostic and perceptual performance. Comparable performance may be due to compensatory behaviour by readers. © 2011 The Authors. Journal of Medical Imaging and Radiation Oncology © 2011 The

  12. A Multi-Valued Diagnostic Model Synthesis Based on Descrete Wavelet Transform

    Directory of Open Access Journals (Sweden)

    Borowczyk Henryk

    2015-01-01

    Full Text Available The method of a multi-valued diagnostic model synthesis using discrete wavelet transform is presented. The method's algorithm consists of three stages: (1 - signal decomposition into low- and high frequency parts - approximations and details, (2 - approximations and details parameterization, (3 - multi-valued encoding parameters obtained in stage 2. The method is illustrated with vibroacoustic signal in real life experiment. The multi-valued diagnostic model is the final result.

  13. Diagnostic yield of oesophageal pH monitoring in patients with chronic unexplained cough

    NARCIS (Netherlands)

    Bogte, Auke; Bredenoord, Arjan J.; Smout, Andre J. P. M.

    2008-01-01

    Objective. One of the main causes of persistent cough is gastro-oesophageal reflux. In these patients, excessive oesophageal acid exposure and/or a temporal association between gastro-oesophageal reflux and cough can be demonstrated during 24-h pH monitoring. Impedance pH monitoring may have a

  14. Diagnostic yield of oesophageal pH monitoring in patients with chronic unexplained cough

    NARCIS (Netherlands)

    Bogte, Auke; Bredenoord, Arjan J.; Smout, André J. P. M.

    2008-01-01

    OBJECTIVE: One of the main causes of persistent cough is gastro-oesophageal reflux. In these patients, excessive oesophageal acid exposure and/or a temporal association between gastro-oesophageal reflux and cough can be demonstrated during 24-h pH monitoring. Impedance pH monitoring may have a

  15. A real-time diagnostic and performance monitor for UNIX. M.S. Thesis

    Science.gov (United States)

    Dong, Hongchao

    1992-01-01

    There are now over one million UNIX sites and the pace at which new installations are added is steadily increasing. Along with this increase, comes a need to develop simple efficient, effective and adaptable ways of simultaneously collecting real-time diagnostic and performance data. This need exists because distributed systems can give rise to complex failure situations that are often un-identifiable with single-machine diagnostic software. The simultaneous collection of error and performance data is also important for research in failure prediction and error/performance studies. This paper introduces a portable method to concurrently collect real-time diagnostic and performance data on a distributed UNIX system. The combined diagnostic/performance data collection is implemented on a distributed multi-computer system using SUN4's as servers. The approach uses existing UNIX system facilities to gather system dependability information such as error and crash reports. In addition, performance data such as CPU utilization, disk usage, I/O transfer rate and network contention is also collected. In the future, the collected data will be used to identify dependability bottlenecks and to analyze the impact of failures on system performance.

  16. Airway flow limitation in patients with vibroacoustic disease.

    Science.gov (United States)

    Reis Ferreira, J M; Couto, A R; Jalles-Tavares, N; Castelo Branco, M S; Castelo Branco, N A

    1999-03-01

    Vibroacoustic disease (VAD) is a pathology caused by occupational exposure to large pressure amplitude and low frequency (LPALF) noise (> or =90 dB SPL, < or =500 Hz), and has been the object of study by this group for the past 20 yr. In a group of 140 VAD-diagnosed patients, 7 non-smoker aircraft technicians developed clinical signs of respiratory insufficiency at an early age. Previously, multi-focal fibrosis had been observed in the lung of Wistar rats exposed to occupationally simulated LPALF noise and with no possibility of contamination by fumes, dust or other chemical agents. The goal of this study is to compare pulmonary imaging and/or functional changes in two age- and exposure-time matched groups of VAD-diagnosed aircraft technicians, with and without airflow limitation symptoms. In a population of 140 individuals occupationally exposed to LPALF noise and diagnosed with VAD, we excluded the smokers (45 cases) and selected 7 individuals with complaints of airway flow limitations, average age 42.3 yr (SD = 2.3). From the remaining non-smokers without respiratory complaints, we selected a group of 15, age-matched patients (average age 36 yr, SD = 6.5). All subjects received a high-resolution CT scan of the chest and respiratory function tests consisting of body plethysmography, spirometry and metacholine airway provocation. There is a significant relationship between the presence of symptoms and imaging of lung fibrosis through high-resolution CT scan (p = 0.03624). There are no significant differences when both groups are compared with respect to the percentage of predicted values of lung function: Vital Capacity (VC), Total Lung Capacity, Forced Expiratory Volume during the first second of expiration, Maximal Expiratory Flow at 50% VC, Total Airway Resistance, and Airway Reactivity after 25 mg of metacholine. High resolution CT scan is a valuable tool for diagnosis of lung fibrosis in VAD patients who have symptoms of airway flow limitations. The fact that

  17. Is intrapartum vibroacoustic stimulation an effective predictor of fetal acidosis?

    Science.gov (United States)

    Lin, C C; Vassallo, B; Mittendorf, R

    2001-01-01

    The hypothesis of this prospective study is that intrapartum vibroacoustic stimulation (VAS) is an effective predictor of fetal acidosis during labor. Various clinical conditions, such as term versus preterm gestation, first stage versus second stage of labor, and fetal heart rate (FHR) variable decelerations versus late decelerations will be tested. During the study period, 113 patients were studied prospectively in either active phase of first stage (n = 53) or during the second stage of labor (n = 60). They were selected from cases exhibiting moderate to severe FHR variable decelerations or late decelerations. The fetuses of study subjects received a VAS for three seconds and FHR changes were recorded. Fetal scalp blood pH or umbilical arterial blood pH was obtained within 15 minutes of VAS. The relationship between FHR responses to VAS and fetal blood pH in term and preterm gestations, the relationship of two tests (VAS and fetal blood pH) to type of FHR decelerations, and the predictability of neonatal morbidity by two tests were analyzed. Where appropriate, Fisher's exact test (p or = 7.20, and between a negative response to VAS (no acceleration or decelerations) and pH or = 37 weeks) and preterm ( or = 34 weeks) fetuses. Since the preterm fetuses enrolled in the study were limited in number, it is difficult to draw adequate conclusions. The positive predictive value (PPV) of fetal acidosis was 67% in both groups of FHR variable decelerations and late decelerations, but the false negative rate of acceleration VAS response for predicting no acidosis was significantly higher in the group of late decelerations (29% vs 8%, p = 0.034). Finally, both a negative VAS response and fetal acidosis (pH < 7.20) have equal predictability for neonatal morbidity. The PPV of NICU admission by a negative VAS response was two times higher than that of fetal acidosis (PPV = 61% vs 29%, p = 0.038). We found that intrapartum VAS was an effective predictor of fetal acidosis in

  18. Vibro-acoustic model of an active aircraft cabin window

    Science.gov (United States)

    Aloufi, Badr; Behdinan, Kamran; Zu, Jean

    2017-06-01

    This paper presents modeling and design of an active structural acoustic control (ASAC) system for controlling the low frequency sound field transmitted through an aircraft cabin window. The system uses stacked piezoelectric elements arranged in a manner to generate out-of-plane actuation point forces acting on the window panel boundaries. A theoretical vibro-acoustic model for an active quadruple-panel system is developed to characterize the dynamic behavior of the system and achieve a good understanding of the active control performance and the physical phenomena of the sound transmission loss (STL) characteristics. The quadruple-panel system represents the passenger window design used in some classes of modern aircraft with an exterior double pane of Plexiglas, an interior dust cover pane and a glazed dimmable pane, all separated by thin air cavities. The STL characteristics of identical pane window configurations with different piezoelectric actuator sets are analyzed. A parametric study describes the influence of important active parameters, such as the input voltage, number and location of the actuator elements, on the STL is investigated. In addition, a mathematical model for obtaining the optimal input voltage is developed to improve the acoustic attenuation capability of the control system. In general, the achieved results indicate that the proposed ASAC design offers a considerable improvement in the passive sound loss performance of cabin window design without significant effects, such as weight increase, on the original design. Also, the results show that the acoustic control of the active model with piezoelectric actuators bonded to the dust cover pane generates high structural vibrations in the radiating panel (dust cover) and an increase in sound power radiation. High active acoustic attenuation can be achieved by designing the ASAC system to apply active control forces on the inner Plexiglas panel or dimmable panel by installing the actuators on the

  19. Diagnostic monitoring of power plants. ; Key to predictive maintenance. Hatsudensho ni okeru shindan kanshi. ; Yobo hozen no yoten

    Energy Technology Data Exchange (ETDEWEB)

    Armor, A.; Scheidel, J.; Blanco, M. (Electric Power Research Institute, (USA))

    1990-10-15

    Together with experience, experienced by power plants at the primary stage of diagnostic monitoring, the present paper explained pioneer work by the EPRI in the field of predictive maintenance, to plan it for its future appearance on the stage. American industrial circle emphasizes the power generation plants to be continuously increasing in number for 30 to 40 years or more years from now on. Accordingly, the necessity is also increasing of pursuring the status of facilities. Actually, the economic profitability of old facilities depends upon ability of detecting unexpected troubles and prevention from main obstacles. It is believed that, by combination of uptodate ability of computer and recently developed ability of sensor, operating even under a severe condition, detection and diagnosis can be made of creep phenomenon, metallic fatigue, corrosion and other degradation effects. Approach by the expert system in the diagnosis has already widened the usability of monitoring unit, which widening is judged to continue from now on. 12 figs., 3 tabs.

  20. The Vector Population Monitoring Tool (VPMT: High-Throughput DNA-Based Diagnostics for the Monitoring of Mosquito Vector Populations

    Directory of Open Access Journals (Sweden)

    Chris Bass

    2010-01-01

    Full Text Available Regular monitoring of mosquito vector populations is an integral component of most vector control programmes. Contemporary data on mosquito species composition, infection status, and resistance to insecticides are a prerequisite for effective intervention. For this purpose we, with funding from the Innovative Vector Control Consortium (IVCC, have developed a suite of high-throughput assays based on a single “closed-tube” platform that collectively comprise the “Vector Population Monitoring Tool” (VPMT. The VPMT can be used to screen mosquito disease vector populations for a number of traits including Anopheles gambiae s.l. and Anopheles funestus species identification, detection of infection with Plasmodium parasites, and identification of insecticide resistance mechanisms. In this paper we focus on the Anopheles-specific assays that comprise the VPMT and include details of a new assay for resistance todieldrin Rdl detection. The application of these tools, general and specific guidelines on their use based on field testing in Africa, and plans for further development are discussed.

  1. A pilot study on diagnostic sensor networks for structure health monitoring.

    Science.gov (United States)

    2013-08-01

    The proposal was submitted in an effort to obtain some preliminary results on using sensor networks for real-time structure health : monitoring. The proposed work has twofold: to develop and validate an elective algorithm for the diagnosis of coupled...

  2. Involvement of central airways in vibroacoustic disease patients

    Directory of Open Access Journals (Sweden)

    José Reis Ferreira

    2006-03-01

    Full Text Available Introduction. Vibroacoustic disease (VAD is the whole-body pathology caused by excessive exposure to LFN. For the past 25 years, it has been know that low frequency noise (LFN, <500 Hz, including infrasound targets the respiratory system. In LFN-exposed rodents, the morphological changes of respiratory tract tissue partially explained some respiratory symptoms reported by VAD patients. However, many questions remain unanswered. Recently, some volunteer VAD patients underwent bronchoscopy in order to ascertain possible damage that could be associated with their respiratory complaints. Methods. Fourteen fully-informed and volunteer VAD patients were submitted to bronchoscopy, and biopsies were removed for analysis. Results. All patients exhibited small submucosal vascular-like lesions near the spurs, consisting of increased collagen and elastin fibres. Histology disclosed cilliary abnormalities, basal membrane hyperplasia, and thickening of vessel walls. In five patients, collagen bundles appeared degenerative and disrupted. No inflammatory process was ever identified, and no differences were seen between smokers and non-smokers. Discussion. Data is in accordance with what was observed in LFN-exposed animal models and also in 8 VAD patients who developed lung tumours. Collagen disruption and degeneration was also observed in electron microscopy images of the respiratory tract of LFN-exposed rodents. Thickened blood and lymphatic vessel walls have been consistently seen in images of VAD patients and of LFN-exposed rodents. During bronchoscopy performed by other reasons, this sort of structural aspects is not frequently seen. Taken together, it is strongly suggested that these findings could be VAD-specific. Resumo: Nos últimos vinte cinco anos constatou-se que o aparelho respiratório constitui um alvo do ruído de baixa frequência (RFB <500Hz, incluindo infra-sons. Denomina-se doença vibroacústica (VAD a patologia sistémica causada pela

  3. Respiratory pathology in vibroacoustic disease: 25 years of research

    Directory of Open Access Journals (Sweden)

    Nuno A.A. Castelo Branco

    2007-01-01

    Full Text Available Background: Respiratory pathology induced by low frequency noise (LFN, <500 Hz, including infrasound is not a novel subject given that in the 1960's, within the context of U.S. and U.S.S.R. Space Programs, other authors have already reported its existence. Within the scope of vibroacoustic disease (VAD, a whole-body pathology caused by excessive exposure to LFN, respiratory pathology takes on specific features. Initially, respiratory pathology was not considered a consequence of LFN exposure; but today, LFN can be regarded as a major agent of disease that targets the respiratory system. The goal of this report is to put forth what is known to date on the clinical signs of respiratory pathology seen in VAD patients. Methods: Data from the past 25 years of research will be taken together and presented. Results: In persons exposed to LFN on the job, respiratory complaints appear after the first 4 years of professional activity. At this stage, they disappear during vacation periods or when the person is removed form his /her workstation for other reasons. With long-term exposure, more serious situations can arise, such as, atypical pleural effusion, respiratory insufficiency, fibrosis and tumours. There is no correlation with smoking habits. In LFN--exposed animal models, morphological changes of the pleura, and loss of the phagocytic ability of pleural mesothelial cells (explaining the atypical pleural effusions. Fibrotic lesions and neo-vascularization were observed along the entire respiratory tract. Fibrosis lesions and neovascularisation were observed throughout the respiratory tract of the animals seen. Pre-malignant lesions, metaplasia e displasia, were also identified. Discussion: LFN is an agent of disease and the respiratory tract is one of its preferential targets. The respiratory pathology associated with VAD needs further in-depth studies in order to achieve a greater understanding, and develop methods of pharmacological intervention

  4. Fetal vibroacoustic stimulation in computerized cardiotocographic analysis: the role of short-term variability and approximate entropy.

    Science.gov (United States)

    Annunziata, Maria Laura; Scala, Mariamaddalena; Giuliano, Natascia; Tagliaferri, Salvatore; Imperato, Olga Carmela Maria; Esposito, Francesca Giovanna; Campanile, Marta; Di Lieto, Andrea

    2012-01-01

    The aim of this study was to evaluate the impact of vibroacoustic stimulation (VAS) on computerized cardiotocography short-term variability (STV) and approximate entropy (ApEn) in both low- and high-risk pregnancies. VAS was performed on 121 high- and 95 low-risk pregnancies after 10 minutes of continuous quiet, while their FHR parameters were monitored and recorded by cCTG analysis. Fetal heart rate was recorded using a computer-assisted equipment. Baseline FHR, accelerations, decelerations, STV, long-term irregularity (LTI), ApEn, and fetal movements (FMs) were calculated for defined observational periods before VAS and after 10 minutes. Data were also investigated in relationship with the perinatal outcome. In each group of patients, FHR after VAS remained almost unmodified. Fetal movements significantly increased after VAS in both groups. Results show that only in the high-risk pregnancies, the increase of STV and the decrease of ApEn after VAS were significantly associated with favorable perinatal outcomes.

  5. Fetal Vibroacoustic Stimulation in Computerized Cardiotocographic Analysis: The Role of Short-Term Variability and Approximate Entropy

    Directory of Open Access Journals (Sweden)

    Maria Laura Annunziata

    2012-01-01

    Full Text Available The aim of this study was to evaluate the impact of vibroacoustic stimulation (VAS on computerized cardiotocography short-term variability (STV and approximate entropy (ApEn in both low- and high-risk pregnancies. VAS was performed on 121 high- and 95 low-risk pregnancies after 10 minutes of continuous quiet, while their FHR parameters were monitored and recorded by cCTG analysis. Fetal heart rate was recorded using a computer-assisted equipment. Baseline FHR, accelerations, decelerations, STV, long-term irregularity (LTI, ApEn, and fetal movements (FMs were calculated for defined observational periods before VAS and after 10 minutes. Data were also investigated in relationship with the perinatal outcome. In each group of patients, FHR after VAS remained almost unmodified. Fetal movements significantly increased after VAS in both groups. Results show that only in the high-risk pregnancies, the increase of STV and the decrease of ApEn after VAS were significantly associated with favorable perinatal outcomes.

  6. Rapid and sensitive detection of Yersinia pestis using amplification of plague diagnostic bacteriophages monitored by real-time PCR.

    Directory of Open Access Journals (Sweden)

    Kirill V Sergueev

    Full Text Available BACKGROUND: Yersinia pestis, the agent of plague, has caused many millions of human deaths and still poses a serious threat to global public health. Timely and reliable detection of such a dangerous pathogen is of critical importance. Lysis by specific bacteriophages remains an essential method of Y. pestis detection and plague diagnostics. METHODOLOGY/PRINCIPAL FINDINGS: The objective of this work was to develop an alternative to conventional phage lysis tests--a rapid and highly sensitive method of indirect detection of live Y. pestis cells based on quantitative real-time PCR (qPCR monitoring of amplification of reporter Y. pestis-specific bacteriophages. Plague diagnostic phages phiA1122 and L-413C were shown to be highly effective diagnostic tools for the detection and identification of Y. pestis by using qPCR with primers specific for phage DNA. The template DNA extraction step that usually precedes qPCR was omitted. phiA1122-specific qPCR enabled the detection of an initial bacterial concentration of 10(3 CFU/ml (equivalent to as few as one Y. pestis cell per 1-microl sample in four hours. L-413C-mediated detection of Y. pestis was less sensitive (up to 100 bacteria per sample but more specific, and thus we propose parallel qPCR for the two phages as a rapid and reliable method of Y. pestis identification. Importantly, phiA1122 propagated in simulated clinical blood specimens containing EDTA and its titer rise was detected by both a standard plating test and qPCR. CONCLUSIONS/SIGNIFICANCE: Thus, we developed a novel assay for detection and identification of Y. pestis using amplification of specific phages monitored by qPCR. The method is simple, rapid, highly sensitive, and specific and allows the detection of only live bacteria.

  7. JAXA Activities on Prediction of Vibroacoustic Prediction for Panel Mounted Equipments

    Science.gov (United States)

    Akagi, Hiroki; Ando, Shigemasa; Yanagase, Keiichi; Shi, Qinzhong

    2012-07-01

    Spacecraft is exposed to the severe random vibration by acoustic during its launch. In the spacecraft design, random vibration of spacecraft equipments mounted on panel structure during launch environments needs to be predicted. In the present methods, SEA is the method for analyzing the high frequency band, FEA is for the low frequency band. This paper introduces major methods of recent years to predict the vibroacoustic response of spacecraft structure, including SEA, Joint Acceptance and most recent approach using Combination of FEA and SEA methods. The Combination method focuses on the vibroacoustic prediction which keeps advantages to use detail model of structure expressed by FEA and statistical energy approach expressed by SEA of reverberant acoustic excitation. These methods are applied to diffuse sound field excitation of honeycomb panel, and compared with the results in test verification.

  8. Prediction of the Vibroacoustic Response of the Equipment Mounted on the Infrared Space Telescope "SPICA"

    Science.gov (United States)

    Akagi, Hiroki; Ando, Shigemasa; Shi, Qinzhong; Yamawaki, Toshiko

    2014-06-01

    The infrared space telescope "SPICA" (Space Infrared Telescope for Cosmology and Astrophysics) is a structurally-complex spacecraft, which requires the less conservative prediction of the random vibration at interface in order to reduce the over-margin issue for designing the strength on critical structure of optical instrument in the early stage of development, and to relieve the risk of overweight designing. This paper proposes Combination of FEA and SEA Methods to predict the vibroacoustic response of the equipment mounted on SPICA, and less conservative specification of the random vibration environments. Furthermore, a method of force-limiting to notch the specification over a certain frequency range during designing and a random vibration test is shown. Force-limiting specification is calculated using a simplified approach by multiplying the article's apparent mass to the equivalent of vibroacoustic response at interface.

  9. Analytical coupled vibroacoustic modeling of membrane-type acoustic metamaterials: Plate model

    Science.gov (United States)

    Chen, Yangyang; Huang, Guoliang; Zhou, Xiaoming; Hu, Gengkai; Sun, Chin-Teh

    2014-12-01

    By considering the membrane's dissipation, the membrane-type acoustic metamaterial (MAM) has been demonstrated as a super absorber for low-frequency sound. In the paper, a theoretical vibroacoustic plate model is developed to reveal sound energy absorption mechanism within the MAM under a plane normal incidence. Based on the plate model in conjunction with the point matching method, the in-plane strain energy of the membrane due to the resonant and antiresonant motion of the attached masses can be accurately captured by solving the coupled vibroacoustic integrodifferential equation. Therefore, the sound absorption of the MAM is obtained and discussed, which is also in good agreement with the prediction from the finite element method. In particular, microstructure effects including eccentricity of the attached masses, the depth, thickness and loss factor of the membrane on sound absorption peak values are quantitatively investigated.

  10. Vibroacoustic Characterization of Corrugated-Core and Honeycomb-Core Sandwich Panels

    Science.gov (United States)

    Allen, Albert; Schiller, Noah

    2016-01-01

    The vibroacoustic characteristics of two candidate launch vehicle fairing structures, corrugated- core and honeycomb-core sandwich designs, were studied. The study of these structures has been motivated by recent risk reduction efforts focused on mitigating high noise levels within the payload bays of large launch vehicles during launch. The corrugated-core sandwich concept is of particular interest as a dual purpose structure due to its ability to harbor resonant noise control systems without appreciably adding mass or taking up additional volume. Specifically, modal information, wavelength dispersion, and damping were determined from a series of vibrometer measurements and subsequent analysis procedures carried out on two test panels. Numerical and analytical modeling techniques were also used to assess assumed material properties and to further illuminate underlying structural dynamic aspects. Results from the tests and analyses described herein may serve as a reference for additional vibroacoustic studies involving these or similar structures.

  11. Vibro-acoustics of ribbed structures: A compact modal formulation for SEA models

    Science.gov (United States)

    Bremner, Paul G.

    Rib-stiffening of plates and shells is a structurally-efficient construction technique common to aerospace, shipbuilding, automotive, and many other industries. Engineers need to be able to design the vibro-acoustic behavior of these panel systems. That is, the panel vibration response to excitation by a sound pressure field and the sound radiated by panel vibration. The effect of adding rib-stiffeners to a uniform thickness, isotropic panel is to cause scattering of the panel free bending waves. The superposition of these wavefields can also be described by modal methods, if the panel has finite dimensions. The effect of rib stiffening is shown to be the re-distribution of resonant frequencies and mode shapes of the panel, which can significantly alter its noise and vibration character. This paper describes a compact modal method for description of the vibro-acoustics of ribbed panels which is currently implemented in the Statistical Energy Analysis modeling package AutoSEA.

  12. Point-of-care coagulation monitoring: first clinical experience using a paper-based lateral flow diagnostic device.

    Science.gov (United States)

    Hegener, Michael A; Li, Hua; Han, Daewoo; Steckl, Andrew J; Pauletti, Giovanni M

    2017-09-01

    Vitamin K antagonists such as warfarin are the most widely used class of oral anticoagulants. Due to a narrow therapeutic window, patients on warfarin require regular monitoring. Self-testing using point-of-care (POC) diagnostic devices is available, but cost makes this monitoring method beyond reach for many. The main objective of this research was to assess the clinical utility of a low-cost, paper-based lateral flow POC diagnostic device developed for anticoagulation monitoring without the need for a separate electronic reader. Custom-fabricated lateral flow assay (LFA) test strips comprised of a glass fiber sample pad, a nitrocellulose analytical membrane, a cellulose wicking pad, and a plastic backing card were assembled in a plastic cassette. Healthy volunteers and patients on warfarin therapy were recruited for this prospective study. For each participant, a whole blood sample was collected via fingerstick to determine: (1) international normalized ratio (INR) using the CoaguChek® XS coagulometer, (2) hematocrit by centrifugation, and (3) red blood cell (RBC) travel distance on the experimental LFA device after 240 s using digital image analysis. RBC travel distance measured on the LFA device using blood samples obtained from warfarin patients positively correlated with increasing INR value and the LFA device had the capability to statistically distinguish between healthy volunteer INR values and those for patients groups with INR ≥ 2.6. From these data, it is predicted that this low-cost, paper-based LFA device can have clinical utility for identifying anticoagulated patients taking vitamin K antagonists who are outside of the desired therapeutic efficacy window.

  13. Shuttle payload vibroacoustic test plan evaluation. Free flyer payload applications and sortie payload parametric variations

    Science.gov (United States)

    Stahle, C. V.; Gongloff, H. R.

    1977-01-01

    A preliminary assessment of vibroacoustic test plan optimization for free flyer STS payloads is presented and the effects on alternate test plans for Spacelab sortie payloads number of missions are also examined. The component vibration failure probability and the number of components in the housekeeping subassemblies are provided. Decision models are used to evaluate the cost effectiveness of seven alternate test plans using protoflight hardware.

  14. The diagnostic value of initial video-EEG monitoring in children--review of 1000 cases.

    Science.gov (United States)

    Asano, Eishi; Pawlak, Carol; Shah, Aashit; Shah, Jagdish; Luat, Aimee F; Ahn-Ewing, Judy; Chugani, Harry T

    2005-01-01

    We retrospectively reviewed the clinical utility of initial video-EEG monitoring in a series of 1000 children suspected of epileptic disorders. The ages of patients (523 boys and 477 girls) ranged from 1 month to 17 years (median age: 7 years). The mean length of stay was 1.5 days (range: 1-10 days). Outcomes were classified as: 'useful-epileptic' (successful classification of epilepsy), 'useful-nonepileptic' (demonstration of nonepileptic habitual events), 'uneventful' (normal EEG without habitual events captured), and 'inconclusive' (inability to clarify the nature of habitual events with abnormal interictal EEG findings). A total of 315 studies were considered 'useful-epileptic'; 219 'useful-nonepileptic'; 224 'uneventful'; 242 'inconclusive'. Longer monitoring was associated with higher rate of a study classified as 'useful-epileptic' in all age groups (Chi square test: pepilepsy were assigned a specific diagnosis of epilepsy syndrome according to the International League Against Epilepsy (ILAE) classification. We found only 22 children with ictal EEG showing a seizure onset purely originating from a unilateral temporal region. Video-EEG monitoring may fail to capture habitual episodes. To maximize the utility of studies in the future, a video-EEG monitoring longer than 3 days should be considered in selected children such as adolescences with habitual events occurring on a less than daily basis. We recognize a reasonable clinical utility of the current ILAE classification in the present study. It may not be common to identify children with pure unilateral temporal lobe epilepsy solely based on video-EEG monitoring.

  15. Synthetic SXR diagnostic using GEM detectors on WEST: development in the prospect of tungsten monitoring

    CERN Document Server

    Jardin, A; O'Mullane, M; Chernyshova, M; Czarski, T; Malinowski, K; Kasprowicz, G; Wojenski, A; Pozniak, K; Malard, P; Bourdelle, C

    2016-01-01

    WEST (Tungsten Environment in Steady-State Tokamak) will be operating by the end of 2016 as a test bed for the ITER divertor components in long pulse operation. In this context, radiative cooling of highly ionized impurities like tungsten (W) sputtered from Plasma Facing Components (PFC) into the plasma core is a critical issue since even small impurity concentrations below 10-4 degrade significantly plasma performances and can lead to radiative collapse. In the plasma core, tungsten emission is dominant in the Soft X-ray (SXR) range 0.1 keV -- 15 keV with complex contributions from line transition, radiative recombination and Bremsstrahlung emission.This paper presents the recent development of a synthetic SXR diagnostic using GEM (Gas Electron Multiplier) detectors. This diagnostic will be used on WEST for W transport studies and will be equipped with two new GEM based poloidal cameras allowing 2D tomographic reconstructions with spectral resolution in energy bands. Thus once GEM response to plasma emissivi...

  16. A diagnostic signal selection scheme for planetary gearbox vibration monitoring under non-stationary operational conditions

    Science.gov (United States)

    Feng, Ke; Wang, KeSheng; Zhang, Mian; Ni, Qing; Zuo, Ming J.

    2017-03-01

    The planetary gearbox, due to its unique mechanical structures, is an important rotating machine for transmission systems. Its engineering applications are often in non-stationary operational conditions, such as helicopters, wind energy systems, etc. The unique physical structures and working conditions make the vibrations measured from planetary gearboxes exhibit a complex time-varying modulation and therefore yield complicated spectral structures. As a result, traditional signal processing methods, such as Fourier analysis, and the selection of characteristic fault frequencies for diagnosis face serious challenges. To overcome this drawback, this paper proposes a signal selection scheme for fault-emphasized diagnostics based upon two order tracking techniques. The basic procedures for the proposed scheme are as follows. (1) Computed order tracking is applied to reveal the order contents and identify the order(s) of interest. (2) Vold-Kalman filter order tracking is used to extract the order(s) of interest—these filtered order(s) constitute the so-called selected vibrations. (3) Time domain statistic indicators are applied to the selected vibrations for faulty information-emphasized diagnostics. The proposed scheme is explained and demonstrated in a signal simulation model and experimental studies and the method proves to be effective for planetary gearbox fault diagnosis.

  17. Vibroacoustic Tailoring of a Rod-Stiffened Composite Fuselage Panel with Multidisciplinary Considerations

    Science.gov (United States)

    Allen, Albert R.; Przekop, Adam

    2015-01-01

    An efficient multi-objective design tailoring procedure seeking to improve the vibroacoustic performance of a fuselage panel while maintaining or reducing weight is presented. The structure considered is the pultruded rod stitched efficient unitized structure, a highly integrated composite structure concept designed for a noncylindrical, next-generation flight vehicle fuselage. Modifications to a baseline design are evaluated within a six-parameter design space including spacing, flange width, and web height for both frame and stringer substructure components. The change in sound power radiation attributed to a design change is predicted using finite-element models sized and meshed for analyses in the 500 Hz, 1 kHz, and 2 kHz octave bands. Three design studies are carried out in parallel while considering a diffuse acoustic field excitation and two types of turbulent boundary-layer excitation. Kriging surrogate models are used to reduce the computational costs of resolving the vibroacoustic and weight objective Pareto fronts. The resulting Pareto optimal designs are then evaluated under a static pressurization ultimate load to assess structural strength and stability. Results suggest that choosing alternative configurations within the considered design space can reduce weight and improve vibroacoustic performance without compromising strength and stability of the structure under the static load condition considered, but the tradeoffs are significantly influenced by the spatial characteristics of the assumed excitation field.

  18. Correlation of FEM/BEM Vibroacoustic Prediction to System-Level Acoustic Test Results

    Science.gov (United States)

    Rodrigues, G.; Ngan, I.; Santiago-Prowald, J.

    2014-06-01

    Coupled FEM/BEM vibroacoustic analyses are employed for deriving spacecraft random vibration environments and supporting the design of low aerial density structures. They offer deterministic predictions which are very accurate at low-frequency and meaningful across all the spectrum of interest for vibroacoustic response.An assessment of the standard procedure of FEM/BEM vibroacoustic analyses was carried out by correlation to measurements from system-level tests of several spacecraft. This allowed a quantification of the typical errors committed, and concluded on the adequacy of applying the standard factor of safety +4dB to the predictions. It was observed that a major source of error is the lack of representativeness of the models of the spacecraft, which adds to the diffuse field idealization made on the acoustic environment inside the fairing and the test chambers. In particular, it was observed a clear impact from a lack of detail of the damping of the structure, and an often crude lumped representation of units and equipment as well as tanks and fixations.

  19. Blunted fetal response to vibroacoustic stimulation following chronic exposure to propranolol.

    Science.gov (United States)

    Sherer, D M; Bentolila, E

    1998-08-01

    A recent, prospective randomized trial has suggested that long-term use of prophylactic beta-adrenergic blocking agents may slow the rate of aortic dilation in those patients with Marfan's syndrome exhibiting evidence of existing dilation. Accordingly, administration of such medication from the midtrimester onward has been advocated in these patients. Acute oral administration of propranolol (80 mg) has been shown to depress fetal heart rate response to vibroacoustic stimulation. We present a case in which chronic administration of propranolol 150 mg/day to a patient with Marfan's syndrome with existing aortic root dilation was associated with repeated abnormal intrapartum fetal heart rate responses to vibroacoustic stimulation. Subsequent delivery of a nonhypoxic, nonacidotic infant suggests that maternal administration of beta-blockers should be considered in the interpretation of results of fetal vibroacoustic stimulation. This case also supports that in similar clinical presentations, ultrasonographic confirmation of the fetal startle response, or alternatively observation of the resulting fetal recoil may be utilized rather than the fetal heart rate, which may be modulated by maternal medications.

  20. Joint Motion Quality in Chondromalacia Progression Assessed by Vibroacoustic Signal Analysis.

    Science.gov (United States)

    Bączkowicz, Dawid; Majorczyk, Edyta

    2016-11-01

    Because of the specific biomechanical environment of the patellofemoral joint, chondral disorders, including chondromalacia, often are observed in this articulation. Chondromalacia via pathologic changes in cartilage may lead to qualitative impairment of knee joint motion. To determine the patellofemoral joint motion quality in particular chondromalacia stages and to compare with controls. Retrospective, comparative study. Voivodship hospitals, university biomechanical laboratory. A total of 89 knees with chondromalacia (25 with stage I; 30 with stage II and 34 with stage III) from 50 patients and 64 control healthy knees (from 32 individuals). Vibroacoustic signal pattern analysis of joint motion quality. For all knees vibroacoustic signals were recorded. Each obtained signal was described by variation of mean square, mean range (R4), and power spectral density for frequency of 50-250 Hz (P1) and 250-450 Hz (P2) parameters. Differences between healthy controls and all chondromalacic knees as well as chondromalacia patellae groups were observed as an increase of analyzed parameters (P vibroacoustic signals, and there seems to be a relationship between the level of signal amplitude as well as frequency and cartilage destruction from the superficial layer to the subchondral bone. IV. Copyright © 2016 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.

  1. Diagnostic uncertainty of herpangina and hand-foot-and-mouth disease and its impact on national enterovirus syndromic monitoring.

    Science.gov (United States)

    Yang, T O; Huang, W-T; Chen, M-H; Chen, P-C

    2016-05-01

    The community burden of enterovirus is often monitored through syndromic monitoring systems based on reported cases of enterovirus-related infection (EVI) diagnoses. The extent to which this is affected by under- and over-diagnosis has not been reported. In Taiwan, children often make more than one healthcare visit during an episode of infection. We used change of diagnosis within an episode of infection as a guide of diagnostic uncertainty in a nationally representative cohort of Taiwanese children (n = 13 284) followed from birth to the 9th birthday through electronic health records. We conducted a nested case-control analysis and estimated cross-diagnosis ratios (CDRs) as the observed proportion of acute respiratory infection (ARI) diagnoses following an EVI diagnosis in excess of background ARI burdens. With 19 357 EVI diagnoses in this cohort, the CDR within 7 days was 1·51 (95% confidence interval 1·45-1·57), confirming a significant excess of ARI diagnoses within the week following an EVI diagnosis. We used age-specific CDRs to calibrate the weekly EVI burden in children aged 3-5 years in 2008, and the difference between observed and calibrated weekly EVI burdens was small. Therefore, there was evidence suggesting a small uncertainty in EVI diagnosis, but the observed EVI burdens through syndromic monitoring were not substantially affected by the small uncertainty.

  2. High frequency bulk resonators for bio/chemical diagnostics and monitoring applications

    DEFF Research Database (Denmark)

    Cagliani, Alberto

    In the environmental monitoring eld there is a vast variety of possible applications for microfabricated MEMS sensors. As an example, a network of miniaturized sensors could detect toxic gases, harmful airbornes, explosives in air or, in liquid, monitor the quality of drinking water...... characterized in terms of electrical properties and mass sensing performance. Chemical and biological mass sensing experiments have been performed in order to investigate the behavior of these devices in dierent environments. The microresonators have been used to detect copper ions in drinking water...... and as temperature sensors in humid environment. Moreover, they have been used as tool to investigate the interaction between water molecules and DNA. Finally, nanograss have been etched into the body of the microresonators in order to improve the mass sensitivy of the devices. On the whole, the experimental results...

  3. Diagnostic indicators for shipboard mechanical systems using non-intrusive load monitoring

    OpenAIRE

    McKay, Thomas Duncan

    2006-01-01

    CIVINS (Civilian Institutions) Thesis document Approved for public release, distribution unlimited This thesis examines the use of Non-intrusive Load Monitoring (NILM) in auxiliary shipboard systems, such as a low pressure air system, to determine the state of equipment in larger connected systems, such as the main propulsion engines. Using data collected on previously installed NILM's at the Naval Surface Warfare Center, Philadelphia DDG-51 Land Based Engineering Site (LBES), major eve...

  4. Online fault diagnostics and testing of area gamma radiation monitor using wireless network

    Science.gov (United States)

    Reddy, Padi Srinivas; Kumar, R. Amudhu Ramesh; Mathews, M. Geo; Amarendra, G.

    2017-07-01

    Periodical surveillance, checking, testing, and calibration of the installed Area Gamma Radiation Monitors (AGRM) in the nuclear plants are mandatory. The functionality of AGRM counting electronics and Geiger-Muller (GM) tube is to be monitored periodically. The present paper describes the development of online electronic calibration and testing of the GM tube from the control room. Two electronic circuits were developed, one for AGRM electronic test and another for AGRM detector test. A dedicated radiation data acquisition system was developed using an open platform communication server and data acquisition software. The Modbus RTU protocol on ZigBee based wireless communication was used for online monitoring and testing. The AGRM electronic test helps to carry out the three-point electronic calibration and verification of accuracy. The AGRM detector test is used to verify the GM threshold voltage and the plateau slope of the GM tube in-situ. The real-time trend graphs generated during these tests clearly identified the state of health of AGRM electronics and GM tube on go/no-go basis. This method reduces the radiation exposures received by the maintenance crew and facilitates quick testing with minimum downtime of the instrument.

  5. A beam position monitor for the diagnostic line in MEBT2 of J-PARC linac

    Science.gov (United States)

    Miura, A.; Tamura, J.; Kawane, Y.

    2017-07-01

    In the linac of the Japan Proton Accelerator Research Complex (J-PARC), the neutral hydrogen (H0) beam from the negative hydrogen ion (H-) beam is one of key issues in mitigating beam losses. To diagnose H0 particles, we installed a set of beam-bump magnets to generate a chicane orbit of the H- beam. The beam position monitors (BPMs) in the beam line are used for orbit correction to maintain the beam displacement within 2.0 mm from the duct center. To measure the beam displacement under different drive currents of the beam-bump magnets, a new wide-range BPM was designed and manufactured to evaluate the horizontal beam position by using a correction function to compensate for non-linearity. We also employed the beam profile monitor (WSM: wire scanner monitor) to measure the H- beam profile, which helped us to compare the beam position measurements. In this paper, the design and the performance of the wide-range BPM are described. In addition, we present a comparison of the beam position measured by the BPM and the WSM.

  6. Frequency of positive results of vibroacoustic stimulation test in evaluating fetus health of pregnant women with non-reactive NST

    Directory of Open Access Journals (Sweden)

    soheila Akbari

    2014-03-01

    Full Text Available Background : Non-Stress Test (NST is one of the most common methods used to evaluat fetus health, which its results are presented as reactive and non-reactive. One of the limitations of this test is the high number of false non-reactive cases. Different studies have suggested a combination of vibroacoustic stimulation and NST to reduce the number of non-reactive cases and duration of the test. Materials and Methods: The present study examined a group of tests, and used simple randomized sampling. The number of the sample was 55 individuals and the data collection tools were NST, sonography instruments, NST result paper, a tooth brusher, a watch, a demographic questionnaire, and a checklist. Vibroacoustic stimulation with an electronic brush was performed on fetus head situated on mother’s abdomen for 3 seconds and then NST was continued for a further 20 minutes. Then the results were recorded. The obtained data were gathered by SPSS 19 software, and analyzed using descriptive statistics. Results: In this study, 85.5% of the non-reactive cases changed into reactive through vibroacoustic stimulation. The amount of false positive was lower with vibroacoustic stimulation in comparison with NST. Conclusion: Vibroacoustic stimulation, as a technique for evaluating fetus health, makes it possible to save time, costs and personnel. It is also leads to sooner and better diagnosis of fetus health.

  7. Distance from an intrauterine hydrophone as a factor affecting intrauterine sound pressure levels produced by the vibroacoustic stimulation test.

    Science.gov (United States)

    Eller, D P; Scardo, J A; Dillon, A E; Klein, A J; Stramm, S L; Newman, R B

    1995-08-01

    The purpose of this study was to determine whether intrauterine sound pressure levels produced by vibroacoustic stimulation were associated with distance from an intrauterine hydrophone in human parturients and to evaluate the effects of distance on the spectrum of the stimulus. Measurements of intrauterine sound were taken in eight volunteer parturients in normal active-phase labor by use of an intrauterine hydrophone. Vibroacoustic stimulation was performed on the maternal abdomen directly overlying the hydrophone; at distance of 5, 10, 15, 20, and 25 cm from the hydrophone; and at the maternal sternum. Intrauterine sound pressure levels were tape-recorded for later analysis. Fetal heart rate and fetal movement were assessed with each vibroacoustic stimulation. Spectral analyses were performed by taking the fast Fourier transform of the tape-recorded stimulation at each position. Analysis of variance with repeated measures indicated a statistically significant decrease (F = 4.1, p = 0.004) in the sound pressure levels as distance increased. Spectral analysis indicated large variability between and within subjects. Sound exposure of the fetal ear is on average decreased as the distance between the ear and the vibroacoustic stimulation is increased. The spectrum of the stimulus produced with vibroacoustic stimulation is highly variable.

  8. Nuclear Energy Research Initiative (NERI): On-Line Intelligent Self-Diagnostic Monitoring for Next Generation Nuclear Plants - Phase I Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    L. J. Bond; S. R. Doctor; R. W. Gilbert; D. B. Jarrell; F. L. Greitzer; R. J. Meador

    2000-09-01

    OAK-B135 This OSTI ID belongs to an IWO and is being released out of the system. The Program Manager Rebecca Richardson has confirmed that all reports have been received. The objective of this project is to design and demonstrate the operation of the real-time intelligent self-diagnostic and prognostic system for next generation nuclear power plant systems. This new self-diagnostic technology is titled, ''On-Line Intelligent Self-Diagnostic Monitoring System'' (SDMS). This project provides a proof-of-principle technology demonstration for SDMS on a pilot plant scale service water system, where a distributed array of sensors is integrated with active components and passive structures typical of next generation nuclear power reactor and plant systems. This project employs state-of-the-art sensors, instrumentation, and computer processing to improve the monitoring and assessment of the power reactor system and to provide diagnostic and automated prognostics capabilities.

  9. Are Standard Diagnostic Test Characteristics Sufficient for the Assessment of Continual Patient Monitoring?

    Science.gov (United States)

    2013-02-01

    Crit Care. 2001;5(4):184–8. 4. Lawless ST. Crying wolf: false alarms in a pediatric intensive care unit. Crit Care Med. 1994;22:981–5. 5. Wald A...8. Bogowicz P, Flores-Mir C, Major PW, Heo G. Sequential analysis applied to clinical trials in dentistry : a systematic review. Evid Based Dent... Pediatr Pulmonol. 2008;43(3):288–96. 28. Sibanda N, Lewsey JD, van der Meulen JH, Stringer MD. Con- tinuous monitoring tools for pediatric surgical outcomes

  10. Research and Development of Hybrid Electric Vehicles CAN-Bus Data Monitor and Diagnostic System through OBD-II and Android-Based Smartphones

    Directory of Open Access Journals (Sweden)

    Yalian Yang

    2013-01-01

    Full Text Available With the rapid development of the smartphone market, future cars seem to have more connections with intelligent cell phone and Internet. Intelligent transportation system (ITS and telematics system have become research focus in recent years. There is an increasing demand for remote monitoring and diagnostic system as the further research of hybrid electric vehicle (HEV goes on. In this paper, a remote controller area network bus (CAN-Bus data monitor and diagnostic system for HEV is presented using on board diagnostic version-II (OBD-II and Android-based smartphone. It is low-cost, convenient, and extensible with smartphone used in the system to realize communication with ELM327 and remote monitoring center wirelessly. The prototype of client and server is developed in Java language, and it is proved by the test that the system works stably and the collected data have practical values.

  11. Brain Functional Network in Alzheimer's Disease: Diagnostic Markers for Diagnosis and Monitoring

    Directory of Open Access Journals (Sweden)

    Guido Rodriguez

    2011-01-01

    Full Text Available Alzheimer's disease (AD is the most common type of dementia that is clinically characterized by the presence of memory impairment and later by impairment in other cognitive domains. The clinical diagnosis is based on interviews with the patient and his/her relatives and on neuropsychological assessment, which are also used to monitor cognitive decline over time. Several biomarkers have been proposed for detecting AD in its earliest stages, that is, in the predementia stage. In an attempt to find noninvasive biomarkers, researchers have investigated the feasibility of neuroimaging tools, such as MR, SPECT, and FDG-PET imaging, as well as neurophysiological measurements using EEG. In this paper, we investigate the brain functional networks in AD, focusing on main neurophysiological techniques, integrating with most relevant functional brain imaging findings.

  12. Development of a majority vote decision module for a self-diagnostic monitoring system for an air-operated valve system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Woo Shin [Dept. of Information and Communication Engineering, Sejong University, Seoul (Korea, Republic of); Chai, Jang Bom [Dept. of Mechanical Engineering, Ajou University, Suwon (Korea, Republic of); Kim, In Taek [Dept. of Information and Communication Engineering, Myongji University, Yongin (Korea, Republic of)

    2015-08-15

    A self-diagnostic monitoring system is a system that has the ability to measure various physical quantities such as temperature, pressure, or acceleration from sensors scattered over a mechanical system such as a power plant, in order to monitor its various states, and to make a decision about its health status. We have developed a self-diagnostic monitoring system for an air-operated valve system to be used in a nuclear power plant. In this study, we have tried to improve the self-diagnostic monitoring system to increase its reliability. We have implemented three different machine learning algorithms, i.e., logistic regression, an artificial neural network, and a support vector machine. After each algorithm performs the decision process independently, the decision-making module collects these individual decisions and makes a final decision using a majority vote scheme. With this, we performed some simulations and presented some of its results. The contribution of this study is that, by employing more robust and stable algorithms, each of the algorithms performs the recognition task more accurately. Moreover, by integrating these results and employing the majority vote scheme, we can make a definite decision, which makes the self-diagnostic monitoring system more reliable.

  13. A Multiband-Instability-Monitor for High-Frequency Intra-Bunch Beam Diagnostics

    CERN Document Server

    Steinhagen, R J; Lucas, T G

    2013-01-01

    The maximum beam particle intensity and minimum emittance that can be injected, accelerated and stored in high-brightness lepton as well as high-energy hadron accelerators is fundamentally limited by self-amplifying beam instabilities, intrinsic to unavoidable imperfections in accelerators. Traditionally, intra-bunch or head-tail particle motion has been measured using fast digitizers, with even using state-of-the-art technology being limited in their effective intra-bunch position resolution to few tens of um in the multi-GHz regime. To improve on the present signal processing, a multiband-instability-monitor (MIM) prototype system has been designed, constructed and tested at the CERN Super- Proton-Synchrotron (SPS) and Large Hadron Collider (LHC). The system splits the signal into multiple equallyspaced narrowfrequency bands that are processed and analysed in parallel. Working with narrow-band signals permits the use of much higher resolution analogue-to-digitalconverters that can be used to resolve nm-scal...

  14. Computation of 2D vibroacoustic wave's dispersion for optimizing acoustic power flow in interaction with adaptive metacomposites

    Science.gov (United States)

    Collet, M.; Ouisse, M.; Ichchou, M.; Ohayon, R.

    2013-04-01

    This paper presents an integrated methodology for optimizing vibroacoustic energy flow in interaction between an adaptive metacomposite made of periodically distributed shunted piezoelectric material glued onto passive plate and open acoustic domain. The computation of interacting Floquet-Bloch propagators is also used to optimize vibroacoustic behavior. The main purpose of this work is first to propose a numerical methodology to compute the fluid-structure multi-modal wave dispersions. In a second step, optimization of electric circuit is used to control the acoustic power flow. 3D standard computation is used to confirm the efficiency of the designed metacomposite in terms of acoustic emissivity and absorption.

  15. [Burn shock, diagnostics, monitoring and fluid therapy of severe burns--new look].

    Science.gov (United States)

    Drozdz, Łukasz; Madry, Ryszard; Struzyna, Jerzy

    2011-01-01

    Pathomechanism of burn shock is associated with an important endocrine disorder and cytokines storm. As a result of the burns are released to bloodstream kinins such as: histamine, serotonin and bradykinin and also inflammatory mediators such as: tromboxans, prostacyclins, prostaglandins and leukotrienes. Arises temporary endothelial failure. Comes to the escape of liquid blood to the tissues and a sudden decrease in the quantity of the fluid in the vessels and appear symptoms of burn shock. Offset of fluids by vascular wall to the extravascular space described mathematically with Landis-Starling law. Treatment of burn shock relies on intensive fluid therapy to fill vessels. Fluid rules are based on infusion crystalloids, colloids, hypersaline or plasma. Effect of fluid resuscitation after severe burn are edemas of whole body. Severe burn receives up to 25 000 ml of fluids intravenous in the first 48 hours after injury. The quantity of water defaulting tissue after 48 hours is even 13 000-18 500 ml which is 300-400% of the volume of blood flow. From 3rd day after burn this may produce symptoms of acute circulatory insufficiency or polycompartment syndrom. Enforces this restrictive fluid treatment and removing significant quantities of water from the bloodstream. In East Poland Burn Center and Reconstructive Surgery we remove even 300-350 ml fluid/h by ultrafiltration during CVVHD CiCa. Additional application hemodynamic monitoring such Vigileo-Flotrac has considerably reduce the amount of complications such as: intra-abdominal hypertension IAH, acute heart syndrome, cerebral edema and pulmonary edema.

  16. Laser-induced breakdown spectroscopy of dental lesions: diagnostic and therapeutic monitoring tool

    Science.gov (United States)

    Borisova, Ekaterina; Uzunov, Tzonko; Penev, Dimitar; Genova, Tsanislava; Avramov, Latchezar

    2016-01-01

    The carious decay develops a tiny area of demineralization on the enamel, which could be detected by element analytic techniques such as laser-induced breakdown spectroscopy (LIBS). That demineralization can quickly turn into a large lesion inside the tooth, it is often discovered too late to prevent the kind of decay that leads to cavities. The same optical LIBS detection approach could be used for monitoring of the caries removal using laser ablation or drilling techniques. For LIBS measurements we applied LIBS 2500Plus (Ocean Optics Inc., Dunedin, USA) system, which consists of seven spectrometric channels, covering spectral region from 200 to 980 nm, which optical resolution 0,05 nm, the spectrometers are connected with sample fiber bundle for 7-channels spectral system to the chamber for solid and liquid samples, Q-switched Nd:YAG laser, at 1 064 nm, with energy per pulse - 40 mJ, which is applied to induce plasma in the samples. LIBS spectra were obtained after single shot of the laser in the region of pathology. Samples investigated by LIBS are extracted teeth from patients, with periodontal problems on different stage of carious lesions, and their LIBS spectra are compared with the LIBS signals obtained from normal enamel and dentine tissues to receive complete picture of the carious lesion development. The major line of our investigations is related to the development of a methodology for real-time optical feedback control during selective ablation of tooth tissues using LIBS. Tooth structures, with and without pathological changes, are compared and their LIBS element analysis is used to differentiate major changes, which occur during tooth carious process and growth.

  17. Out of Hours Emergency Computed Tomography Brain Studies: Comparison of Standard 3 Megapixel Diagnostic Workstation Monitors With the iPad 2.

    Science.gov (United States)

    Salati, Umer; Leong, Sum; Donnellan, John; Kok, Hong Kuan; Buckley, Orla; Torreggiani, William

    2015-11-01

    The purpose was to compare performance of diagnostic workstation monitors and the Apple iPad 2 (Cupertino, CA) in interpretation of emergency computed tomography (CT) brain studies. Two experienced radiologists interpreted 100 random emergency CT brain studies on both on-site diagnostic workstation monitors and the iPad 2 via remote access. The radiologists were blinded to patient clinical details and to each other's interpretation and the study list was randomized between interpretations on different modalities. Interobserver agreement between radiologists and intraobserver agreement between modalities was determined and Cohen kappa coefficients calculated for each. Performance with regards to urgent and nonurgent abnormalities was assessed separately. There was substantial intraobserver agreement of both radiologists between the modalities with overall calculated kappa values of 0.959 and 0.940 in detecting acute abnormalities and perfect agreement with regards to hemorrhage. Intraobserver agreement kappa values were 0.939 and 0.860 for nonurgent abnormalities. Interobserver agreement between the 2 radiologists for both diagnostic monitors and the iPad 2 was also substantial ranging from 0.821-0.860. The iPad 2 is a reliable modality in the interpretation of CT brain studies in them emergency setting and for the detection of acute and chronic abnormalities, with comparable performance to standard diagnostic workstation monitors. Copyright © 2015 Canadian Association of Radiologists. Published by Elsevier Inc. All rights reserved.

  18. Vibroacoustic flexural properties of symmetric honeycomb sandwich panels with composite faces

    Science.gov (United States)

    Guillaumie, Laurent

    2015-05-01

    The vibroacoustic bending properties of honeycomb sandwich panels with composite faces are studied from the wavenumber modulus to the mechanical impedance, passing through the modal density. Numerical results extracted from finite element software computations are compared with analytical results. In both cases, the homogenization method is used to calculate the global properties of the sandwich panel. Since faces are made of composite material, the classical laminate theory serves as reference. With particular conditions used in the application for symmetric panels, the original orthotropic mechanical properties can be reduced simply to three parameters commonly used in vibroacoustic characterizations. These three parameters are the mass per unit area, the bending rigidity and the out-of-plane shear rigidity. They simultaneously govern the wavenumber modulus, the modal frequencies, the modal density and the mechanical impedance. For all of these vibroacoustic characterizations, a special frequency called the transition frequency separates two domains. In the first domain, below the transition frequency or for low frequencies, the orthotropic sandwich panel has a classical isotropic plate behavior. In the second domain, above the transition frequency or for high frequencies, the out-of-plane shear rigidity is very significant and changes the behavior. However, the results discussed are only valid up to a certain frequency which is determined by the thickness and out-of-plane shear stiffness of the honeycomb core, the thickness and the bending stiffness of the laminated face sheets and then the mass per unit area and bending stiffness of the total sandwich structure. All these parameters influence the final choice of model and simplifications presented. Experimental measurements of the bending wavenumber modulus and modal frequencies for our own application were carried out. In the vibroacoustic domain, the critical frequency is also an important frequency. It again

  19. Eigensolutions to a vibroacoustic interior coupled problem with a perturbation method

    Science.gov (United States)

    Claude, Bertille; Duigou, Laetitia; Girault, Gregory; Cadou, Jean-Marc

    2017-02-01

    In this paper, an efficient and robust numerical method is proposed to solve non-symmetric eigenvalue problems resulting from the spatial discretization with the finite element method of a vibroacoustic interior problem. The proposed method relies on a perturbation method. Finding the eigenvalues consists in determining zero values of a scalar that depends on angular frequency. Numerical tests show that the proposed method is not sensitive to poorly conditioned matrices resulting from the displacement-pressure formulation. Moreover, the computational times required with this method are lower than those needed with a classical technique such as, for example, the Arnoldi method.

  20. Determining generalized indicator for vibroacoustic hazard at workplaces of mining machines

    Energy Technology Data Exchange (ETDEWEB)

    Rezniko, I.G.

    1986-10-01

    A method is presented for calculating vibroacoustic damage to operators which is based on measuring the noise and vibration levels which occur at the workplace. A value for this indicator is presented for several types of mining machines (e.g. drills, cutter loaders, excavators etc.). It is emonstrated that when an operator is subjected to the combined effect of hazardous factors, the permissible levels of noise and vibration should be 1 1/2 times lower than those established in health and safety standards. 6 references.

  1. Vibroacoustic Payload Environment Prediction System (VAPEPS): VAPEPS management center remote access guide

    Science.gov (United States)

    Fernandez, J. P.; Mills, D.

    1991-01-01

    A Vibroacoustic Payload Environment Prediction System (VAPEPS) Management Center was established at the JPL. The center utilizes the VAPEPS software package to manage a data base of Space Shuttle and expendable launch vehicle payload flight and ground test data. Remote terminal access over telephone lines to the computer system, where the program resides, was established to provide the payload community a convenient means of querying the global VAPEPS data base. This guide describes the functions of the VAPEPS Management Center and contains instructions for utilizing the resources of the center.

  2. Vibroacoustic study of the NASA Goddard Space Flight Center OSS-1 payload

    Science.gov (United States)

    Lee, Y. A.; Henricks, W.

    1985-01-01

    A comparative evaluation of shuttle liftoff and ground test random response data obtained from the Office of Space Science-1 (OSS-1) pallet payload flown in the cargo bay of STS-3 is presented. The study was initiated to evaluate the possibility that the payload flight vibration response can exceed that occurred during ground test when the ground test acoustic excitation is normalized to the flight acoustic environment. In addition, the analytically derived response from the Vibroacoustic Payload Environment Prediction System (VAPEPS) is compared with OSS-1 ground test results.

  3. About the Big Graphs Arising when Forming the Diagnostic Models in a Reconfigurable Computing Field of Functional Monitoring and Diagnostics System of the Spacecraft Onboard Control Complex

    Directory of Open Access Journals (Sweden)

    L. V. Savkin

    2015-01-01

    Full Text Available One of the problems in implementation of the multipurpose complete systems based on the reconfigurable computing fields (RCF is the problem of optimum redistribution of logicalarithmetic resources in growing scope of functional tasks. Irrespective of complexity, all of them are transformed into an orgraph, which functional and topological structure is appropriately imposed on the RCF based, as a rule, on the field programmable gate array (FPGA.Due to limitation of the hardware configurations and functions realized by means of the switched logical blocks (SLB, the abovementioned problem becomes even more critical when there is a need, within the strictly allocated RCF fragment, to realize even more complex challenge in comparison with the problem which was solved during the previous computing step. In such cases it is possible to speak about graphs of big dimensions with respect to allocated RCF fragment.The article considers this problem through development of diagnostic algorithms to implement diagnostics and control of an onboard control complex of the spacecraft using RCF. It gives examples of big graphs arising with respect to allocated RCF fragment when forming the hardware levels of a diagnostic model, which, in this case, is any hardware-based algorithm of diagnostics in RCF.The article reviews examples of arising big graphs when forming the complicated diagnostic models due to drastic difference in formation of hardware levels on closely located RCF fragments. It also pays attention to big graphs emerging when the multichannel diagnostic models are formed.Three main ways to solve the problem of big graphs with respect to allocated RCF fragment are given. These are: splitting the graph into fragments, use of pop-up windows with relocating and memorizing intermediate values of functions of high hardware levels of diagnostic models, and deep adaptive update of diagnostic model.It is shown that the last of three ways is the most efficient

  4. Identification and differentiation of Panax ginseng, Panax quinquefolium, and Panax notoginseng by monitoring multiple diagnostic chemical markers

    Directory of Open Access Journals (Sweden)

    Wenzhi Yang

    2016-10-01

    Full Text Available To differentiate traditional Chinese medicines (TCM derived from congeneric species in TCM compound preparations is usually challenging. The roots of Panax ginseng (PG, Panax quinquefolium (PQ and Panax notoginseng (PN are used as popular TCM. They contain similar triterpenoid saponins (ginsenosides as the major bioactive constituents. Thus far, only a few chemical markers have been discovered to differentiate these three species. Herein we present a multiple marker detection approach to effectively differentiate the three Panax species, and to identify them in compound preparations. Firstly, 85 batches of crude drug samples (including 32 PG, 30 PQ, and 23 PN were analyzed by monitoring 40 major ginsenosides in the extracted ion chromatograms (EICs using a validated LC–MS fingerprinting method. Secondly, the samples were clustered into different groups by pattern recognition chemometric approaches using PLS-DA and OPLS-DA models, and 17 diagnostic chemical markers were discovered. Aside from the previously known Rf and p-F11, ginsenoside Rs1 could be a new marker to differentiate PG from PQ. Finally, the above multiple chemical markers were used to identify the Panax species in 60 batches of TCM compound preparations.

  5. On-Line Monitoring and Diagnostics of the Integrity of Nuclear Plant Steam Generators and Heat Exchangers

    Energy Technology Data Exchange (ETDEWEB)

    Belle R. Upadhyaya; J. Wesley Hines

    2004-09-27

    Integrity monitoring and flaw diagnostics of flat beams and tubular structures was investigated in this research task using guided acoustic signals. A piezo-sensor suite was deployed to activate and collect Lamb wave signals that propagate along metallic specimens. The dispersion curves of Lamb waves along plate and tubular structures are generated through numerical analysis. Several advanced techniques were explored to extract representative features from acoustic time series. Among them, the Hilbert-Huang transform (HHT) is a recently developed technique for the analysis of non-linear and transient signals. A moving window method was introduced to generate the local peak characters from acoustic time series, and a zooming window technique was developed to localize the structural flaws. The time-frequency analysis and pattern recognition techniques were combined for classifying structural defects in brass tubes. Several types of flaws in brass tubes were tested, both in the air and in water. The techniques also proved to be effective under background/process noise. A detailed theoretical analysis of Lamb wave propagation was performed and simulations were carried out using the finite element software system ABAQUS. This analytical study confirmed the behavior of the acoustic signals acquired from the experimental studies. The report presents the background the analysis of acoustic signals acquired from piezo-electric transducers for structural defect monitoring. A comparison of the use of time-frequency techniques, including the Hilbert-Huang transform, is presented. The report presents the theoretical study of Lamb wave propagation in flat beams and tubular structures, and the need for mode separation in order to effectively perform defect diagnosis. The results of an extensive experimental study of detection, location, and isolation of structural defects in flat aluminum beams and brass tubes are presented. The results of this research show the feasibility of on

  6. MINIMIZATION OF VIBROACOUSTIC EFFECTS AS A CRITERION FOR OPERATION OF GEAR TRANSMISSIONS IN ACCORDANCE WITH SUSTAINABLE DEVELOPMENT PRINCIPLES

    Directory of Open Access Journals (Sweden)

    Andrzej N. WIECZOREK

    2016-01-01

    Full Text Available In correctly functioning maintenance systems it is most important to prevent possible failures. A reduction of the vibroacoustic effects accompanying the operation of machines and equipment, including transmissions, is among the factors that lower the probability of a failure. The paper presents the results of the research on the impact of operational factors on vibroacoustic conditions of transmissions. The factors covered by the analysis included a change in the mating conditions of gear wheels associated with the wear of tooth surfaces, operation of transmissions in subharmonic conditions of the main resonance and the temperature of the lubricating oil. The study demonstrated that it was possible to reduce the vibroacoustic effects generated by gear transmissions by changing the conditions of their operation. Based on the results obtained, it has been found that the operation of gear transmissions in accordance with the sustainable development principles requires technical services to take active measures consisting in the search for optimal operating conditions in terms of the vibroacoustic conditions.

  7. Vibroacoustic analysis and experimental validation of the structural responses of NASA Mars Exploration Rover spacecraft due to acoustic launch load

    Science.gov (United States)

    Hwang, H. J.

    2003-01-01

    Structural responses of a spacecraft during liftoff are dominated by the intense acoustic pressure field imping on the exterior of the launch vehicle. Statistical Energy Analysis model of the NASA Mars Exploration Rover spacecraft has been developed and the SEA model was analyzed to predict vibroacoustic responses of the spacecraft under the diffuse acoustic loading condition.

  8. Effect of abdominal vibroacoustic stimulation on sound and acceleration levels at the head of the fetal sheep.

    Science.gov (United States)

    Abrams, R M; Peters, A J; Gerhardt, K J

    1997-08-01

    To measure the vibratory response of the fetal head and abdominal wall in sheep during vibroacoustic stimulation. A piezoresistive accelerometer was attached to the skulls of seven sheep fetuses (128-134 days' gestational age), and a miniature hydrophone was attached to the skin overlying the fetal temporal bone. During fetal preparation and vibroacoustic stimulation procedures, ewes were anesthetized and supine. Vibroacoustic stimulation of the maternal abdomen was produced by each of two clinical devices that differed in spectral content, and an electric toothbrush. The approximate fundamental frequencies (f0) and first overtones (f1), as determined by both recordings of intrauterine sound pressure level and fetal head acceleration, were as follows: fetal acoustic stimulator, 75 and 150 Hz; electronic larynx, 150 and 300 Hz; and electric toothbrush, 25 and 50 Hz, respectively. At fundamental frequencies and first overtones, the ranges of fetal head accelerations (expressed in 1/12-octave bands) were as follows: fetal acoustic stimulator, 10-53 and 25-224 mm/sec2; electronic larynx, 10-53 and 18-114 mm/sec2; and electric toothbrush, 33-792 and 8-116 mm/sec2, respectively. Sound pressure levels exceeded 110 dB in all cases. High sound pressure levels in the uterus were proportional to fetal head vibration levels. Vibroacoustic stimulation of the surface of the abdomen of pregnant sheep is accompanied by both acoustic and vibratory exposure of the fetus.

  9. Fuzzy structure theory modeling of sound-insulation layers in complex vibroacoustic uncertain systems: theory and experimental validation.

    Science.gov (United States)

    Fernandez, Charles; Soize, Christian; Gagliardini, Laurent

    2009-01-01

    The fuzzy structure theory was introduced 20 years ago in order to model the effects of complex subsystems imprecisely known on a master structure. This theory was only aimed at structural dynamics. In this paper, an extension of that theory is proposed in developing an elastoacoustic element useful to model sound-insulation layers for computational vibroacoustics of complex systems. The simplified model constructed enhances computation time and memory allocation because the number of physical and generalized degrees of freedom in the computational vibroacoustic model is not increased. However, these simplifications introduce model uncertainties. In order to take into account these uncertainties, the nonparametric probabilistic approach recently introduced is used. A robust simplified model for sound-insulation layers is then obtained. This model is controlled by a small number of physical and dispersion parameters. First, the extension of the fuzzy structure theory to elastoacoustic element is presented. Second, the computational vibroacoustic model including such an elastoacoustic element to model sound-insulation layer is given. Then, a design methodology to identify the model parameters with experiments is proposed and is experimentally validated. Finally, the theory is applied to an uncertain vibroacoustic system.

  10. Modeling of micro-perforated panels in a complex vibro-acoustic environment using patch transfer function approach.

    Science.gov (United States)

    Maxit, L; Yang, C; Cheng, L; Guyader, J-L

    2012-03-01

    A micro-perforated panel (MPP) with a backing cavity is a well known device for efficient noise absorption. This configuration has been thoroughly studied in the experimental conditions of an acoustic tube (Kundt tube), in which the MPP is excited by a normal incident plane wave in one dimension. In a more practical situation, the efficiency of MPP may be influenced by the vibro-acoustic behavior of the surrounding systems as well as excitation. To deal with this problem, a vibro-acoustic formulation based on the patch transfer functions (PTF) approach is proposed to model the behavior of a micro-perforated structure in a complex vibro-acoustic environment. PTF is a substructuring approach, which allows assembling different vibro-acoustic subsystems through coupled surfaces. Upon casting micro-perforations and the flexibility of the MPP under transfer function framework, the proposed PTF formulation provides explicit representation of the coupling between subsystems and facilitates physical interpretation. As an illustration example, application to a MPP with a backing cavity located in an infinite baffle is demonstrated. The proposed PTF formulation is finally validated through comparison with experimental measurements available in the literature. © 2012 Acoustical Society of America

  11. Vibroacoustic stimulation for fetal assessment in labour in the presence of a nonreassuring fetal heart rate trace.

    Science.gov (United States)

    East, C E; Smyth, R; Leader, L R; Henshall, N E; Colditz, P B; Tan, K H

    2005-04-18

    Fetal vibroacoustic stimulation is a simple, non-invasive technique where a device is placed on the maternal abdomen over the region of the fetal head and sound is emitted at a predetermined level for several seconds. It is hypothesized that the resultant startle reflex in the fetus and subsequent fetal heart rate acceleration or transient tachycardia following vibroacoustic stimulation provide reassurance of fetal well-being. This technique has been proposed as a tool to assess fetal well-being in the presence of a non-reassuring cardiotocographic trace during the first and second stages of labour. To evaluate the clinical effectiveness and safety of vibroacoustic stimulation in the assessment of fetal well-being during labour, compared with mock or no stimulation for women with a singleton pregnancy exhibiting a non-reassuring fetal heart rate pattern. We searched the Cochrane Pregnancy and Childbirth Group Trials Register (30 September 2004), the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 1, 2004), MEDLINE (January 1966 to January 2005), EMBASE (January 1966 to January 2005) and reference lists of all retrieved articles. We sought unpublished trials and abstracts submitted to major international congresses and contacted expert informants. All published and unpublished randomised trials that compared maternal and fetal/neonatal/infant outcomes when vibroacoustic stimulation was used to evaluate fetal status in the presence of a non-reassuring cardiotocographic trace during labour, compared with mock or no stimulation. Two independent review authors identified potential studies from the literature search and assessed them for methodological quality and appropriateness of inclusion, using a data extraction form. Attempts to contact study authors for additional information were unsuccessful. The search strategies yielded six studies for consideration of inclusion. However, none of these studies fulfilled the requirements for

  12. Technical Note: Nanometric organic photovoltaic thin film detectors for dose monitoring in diagnostic x-ray imaging

    Energy Technology Data Exchange (ETDEWEB)

    Elshahat, Bassem [Medical Physics Program, Department of Physics and Applied Physics, University of Massachusetts Lowell, Lowell, Massachusetts 01854 and Department of Medical Imaging, Royal Jubilee Hospital, Vancouver Island Health Authority, Victoria, British Columbia V8R 1J8 (Canada); Gill, Hardeep Singh; Kumar, Jayant [Department of Physics and Applied Physics, University of Massachusetts Lowell, Lowell, Massachusetts 01854 (United States); Filipyev, Ilya; Zygmanski, Piotr [Harvard Medical School, Dana Farber Cancer Institute and Brigham and Women’s Hospital, Boston, Massachusetts 02215 (United States); Shrestha, Suman; Karellas, Andrew [Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655 (United States); Hesser, Jürgen [Department of Radiation Oncology, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, Mannheim 68167 (Germany); Sajo, Erno [Medical Physics Program, Department of Physics and Applied Physics, University of Massachusetts Lowell, Lowell, Massachusetts 01854 (United States)

    2015-07-15

    Purpose: To fabricate organic photovoltaic (OPV) cells with nanometric active layers sensitive to ionizing radiation and measure their dosimetric characteristics in clinical x-ray beams in the diagnostic tube potential range of 60–150 kVp. Methods: Experiments were designed to optimize the detector’s x-ray response and find the best parameter combination by changing the active layer thickness and the area of the electrode. The OPV cell consisted of poly (3-hexylthiophene-2,5-diyl): [6,6]-phenyl C{sub 61} butyric acid methyl ester photoactive donor and acceptor semiconducting organic materials sandwiched between an aluminum electrode as an anode and an indium tin oxide electrode as a cathode. The authors measured the radiation-induced electric current at zero bias voltage in all fabricated OPV cells. Results: The net OPV current as a function of beam potential (kVp) was proportional to kVp{sup −0.5} when normalized to x-ray tube output, which varies with kVp. Of the tested configurations, the best combination of parameters was 270 nm active layer thicknesses with 0.7 cm{sup 2} electrode area, which provided the highest signal per electrode area. For this cell, the measured current ranged from approximately 0.7 to 2.4 nA/cm{sup 2} for 60–150 kVp, corresponding to about 0.09 nA–0.06 nA/mGy air kerma, respectively. When compared to commercial amorphous silicon thin film photovoltaic cells irradiated under the same conditions, this represents 2.5 times greater sensitivity. An additional 40% signal enhancement was observed when a 1 mm layer of plastic scintillator was attached to the cells’ beam-facing side. Conclusions: Since both OPVs can be produced as flexible devices and they do not require external bias voltage, they open the possibility for use as thin film in vivo detectors for dose monitoring in diagnostic x-ray imaging.

  13. The vibroacoustic response and sound absorption performance of multilayer, microperforated rib-stiffened plates

    Science.gov (United States)

    Zhou, Haian; Wang, Xiaoming; Wu, Huayong; Meng, Jianbing

    2017-10-01

    The vibroacoustic response and sound absorption performance of a structure composed of multilayer plates and one rigid back wall are theoretically analyzed. In this structure, all plates are two-dimensional, microperforated, and periodically rib-stiffened. To investigate such a structural system, semianalytical models of one-layer and multilayer plate structures considering the vibration effects are first developed. Then approaches of the space harmonic method and Fourier transforms are applied to a one-layer plate, and finally the cascade connection method is utilized for a multilayer plate structure. Based on fundamental acoustic formulas, the vibroacoustic responses of microperforated stiffened plates are expressed as functions of a series of harmonic amplitudes of plate displacement, which are then solved by employing the numerical truncation method. Applying the inverse Fourier transform, wave propagation, and linear addition properties, the equations of the sound pressures and absorption coefficients for the one-layer and multilayer stiffened plates in physical space are finally derived. Using numerical examples, the effects of the most important physical parameters—for example, the perforation ratio of the plate, sound incident angles, and periodical rib spacing—on sound absorption performance are examined. Numerical results indicate that the sound absorption performance of the studied structure is effectively enhanced by the flexural vibration of the plate in water. Finally, the proposed approaches are validated by comparing the results of stiffened plates of the present work with solutions from previous studies.

  14. The Vibro-Acoustic Modelling of Slab Track with Embedded Rails

    Science.gov (United States)

    VAN LIER, S.

    2000-03-01

    The application of concrete slab track in railways has certain advantages compared with conventional ballasted track, but conventional slab track structures generally produce more noise than ballasted track. For this reason a “silent slab track” has been developed in the Dutch ICES “Stiller Treinverkeer” project (silent railway traffic) by optimizing the track. In the design, the rails are embedded in a cork-filled elastomeric material. The paper discusses the vibro-acoustic modelling of this track using the simulation package “TWINS”, combined with finite element techniques. The model evaluates the one-third octave band sound power spectrum radiated by train wheels and track, and provides for a tool to optimize the track design. Three track types are compared using the vibro-acoustic model: an existing slab track with embedded UIC54 rails, a newly designed, acoustically optimized slab track with a less stiff rail embedded in a stiffer elastomere, and, as a reference, a ballasted track. The models of the existing tracks have been validated with measurements. Calculations indicate that the optimized slab track will emit between 4 and 6 dB(A) less noise than the ballasted track. The existing slab track produces between 1·5 and 3 dB(A) more noise than the ballasted track; this is caused by resonances in the elastomeric moulding material in the frequency range determining the dB(A)-level.

  15. Reconstruction of vibroacoustic responses of a highly nonspherical structure using Helmholtz equation least-squares method.

    Science.gov (United States)

    Lu, Huancai; Wu, Sean F

    2009-03-01

    The vibroacoustic responses of a highly nonspherical vibrating object are reconstructed using Helmholtz equation least-squares (HELS) method. The objectives of this study are to examine the accuracy of reconstruction and the impacts of various parameters involved in reconstruction using HELS. The test object is a simply supported and baffled thin plate. The reason for selecting this object is that it represents a class of structures that cannot be exactly described by the spherical Hankel functions and spherical harmonics, which are taken as the basis functions in the HELS formulation, yet the analytic solutions to vibroacoustic responses of a baffled plate are readily available so the accuracy of reconstruction can be checked accurately. The input field acoustic pressures for reconstruction are generated by the Rayleigh integral. The reconstructed normal surface velocities are validated against the benchmark values, and the out-of-plane vibration patterns at several natural frequencies are compared with the natural modes of a simply supported plate. The impacts of various parameters such as number of measurement points, measurement distance, location of the origin of the coordinate system, microphone spacing, and ratio of measurement aperture size to the area of source surface of reconstruction on the resultant accuracy of reconstruction are examined.

  16. The conformity of BPP and vibroacoustic stimulation results in fetal non reactive non stress test

    Directory of Open Access Journals (Sweden)

    M. Modarres

    2006-08-01

    Full Text Available Background: The most frequently used test for evaluation of fetal health is the Non Stress Test (NST. Unfortunately it has a high incidence of false positive results. The combination of vibroacoustic stimulation with the NTS has been shown to reduce non reactive results. Methods: A tests assessment method was chosen with a simple randomized sampling. 40 pregnant women with non reactive NST in the first 20 minutes who received VAS in one of Tehran University's Hospitals were compared with BPP scores. A vibroacoustic stimulation was applied for a 3 seconds on the maternal abdomen and fallowed within 10 minutes.Data collection tools were NST, sonography instruments ,NST result paper, tooth brusher, watch, demographic questioner and check list. Data analysis was made by descriptive static and by using the Fisher's Exact Test (with level of significant at p<0/05. All statistical analysis were performed using an spss/win. Results: After VAS, 70% of non reactive tracing became reactive. All cases with fetal reactivity response after a VAS had a subsequent BPP score of 8 (negative predictive value of 100%. False positivity of VAS was lower than NST. Conclusion: VAS offers benefits, by decreasing the incidence of non reactive test and reducing test time. VAS lowers the rate of false positive NST. VAS is safe and allows more efficient of prenatal services. This test could be used as a rapid antepartum test to predict fetal well-being.

  17. Stochastic BEM for the Vibroacoustic Analysis of Three-Dimensional Structures

    Directory of Open Access Journals (Sweden)

    R. D'Amico

    2011-01-01

    Full Text Available Nowadays, extending the NVH prediction reliability to the whole frequency range is an attractive goal of vibroacoustics. Deterministic methodologies are well established for the low-frequency range, but, decreasing the wavelength, energy-based methods are necessary. In such a range, a crucial role is played by small perturbations which highly influence the response sensitivity. Moreover, taking into account these variations allows to make the product design more robust and even quicker. Introducing geometrical uncertainties within the classic BEM formulation allows to obtain the so-called stochastic BEM. As a result, the solution shows deterministic behaviour at low frequencies; decreasing the wavelength, the effect of the uncertainties smooths the response. Consequently, it is possible to obtain an averaged trend over the whole frequency range which asymptotically tends to the deterministic one. In this paper, we deal with three-dimensional acoustic SBEM. First, the formulation and its basic assumptions are presented. Secondly, they are applied to academic cases to show its potentialities in predicting vibroacoustic behaviour over a wide frequency range.

  18. Reconstruction of vibroacoustic fields in half-space by using hybrid near-field acoustical holography.

    Science.gov (United States)

    Zhao, Xiang; Wu, Sean F

    2005-02-01

    In this paper we examine the accuracy and efficiency of reconstructing the vibroacoustic quantities generated by a vibrating structure in half-space by using hybrid near-field acoustic holography (NAH) and modified Helmholtz equation least squares (HELS) formulations. In hybrid NAH, we combine modified HELS with an inverse boundary element method (IBEM) to reconstruct a vibroacoustic field. The main advantage of this approach is that the majority of the input data can be regenerated but not measured, thus the efficiency is greatly enhanced. In modified HELS, we expand the field acoustic pressure in terms of outgoing and incoming spherical waves and specify the corresponding expansion coefficients by solving a system of equations obtained by matching the assumed-form solution to the measured acoustic pressure. Here the system of equations is ill conditioned and Tikhonov regularization is implemented through singular value decomposition (SVD) and the generalized cross-validation (GCV) method. Numerical examples of a dilating and oscillating spheres and finite cylinder are demonstrated. Test results show that hybrid NAH can yield a more accurate reconstruction than does a modified HELS, but a modified HELS is more efficient than is hybrid NAH [Work supported by NSF].

  19. Numerical vibroacoustic analysis of plates with constrained-layer damping patches.

    Science.gov (United States)

    Loredo, Alexandre; Plessy, Arnaud; El Hafidi, Ali; Hamzaoui, Nacer

    2011-04-01

    A numerical vibroacoustic model that can manage multilayered plates locally covered with damping patches is presented. All the layers can have an on-axis orthotropic viscoelastic behavior. Continuity of displacements and transverse shear stresses at each interface is enforced, which permits to write the entire displacement field in function of the displacements of the--common--first layer, leading to a two-dimensional plate model. The problem is then discretized by Rayleigh-Ritz's method using a trigonometric basis that includes both sine and cosine functions in order to treat various boundary conditions. The excitation can be of mechanical kind (concentrated or distributed forces) or of acoustic kind (plane wave of any incidence, diffuse field, etc.). The model permits to compute different vibroacoustic indicators: the mean square velocity of the plate, the radiation efficiency, and the transmission loss. Comparisons between the present model and numerical results from literature or finite element computations show that the model gives good results in both mechanical and acoustical aspects. Then, a comparison of the effects of different distributions of patches is presented. The role of the surface covering rate is first discussed, followed by a study involving different geometries for the same surface covering rate.

  20. Solving the vibroacoustic equations of plates by minimization of error on a sample of observation points.

    Science.gov (United States)

    Collery, Olivier; Guyader, Jean-Louis

    2010-03-01

    In the context of better understanding and predicting sound transmission through heterogeneous fluid-loaded aircraft structures, this paper presents a method of solving the vibroacoustic problem of plates. The present work considers fluid-structure coupling and is applied to simply supported rectangular plates excited mechanically. The proposed method is based on the minimization of the error of verification of the plate vibroacoustic equation of motion on a sample of points. From sampling comes an aliasing effect; this phenomenon is described and solved using a wavelet-based filter. The proposed approach is validated in presenting very accurate results of sound radiation immersed in heavy and light fluids. The fluid-structure interaction appears to be very well described avoiding time-consuming classical calculations of the modal radiation impedances. The focus is also put on different samplings to observe the aliasing effect. As perspectives sound radiation from a non-homogeneous plate is solved and compared with reference results proving all the power of this method.

  1. A study of vibroacoustic coupling between a pump and attached water-filled pipes.

    Science.gov (United States)

    Li, Bilong; Hodkiewicz, Melinda; Pan, Jie

    2007-02-01

    This paper presents a model for the vibroacoustical behavior of a pump coupled with water-filled pipes. Coupling between (a) the pump and the inlet and outlet pipes, and (b) the pipe wall and the fluid contained in the pipe, is investigated through analytical modeling and numerical simulation. In the model, the pump is represented by a rigid body supported by multiple elastic mounts, and the inlet and outlet pipes by two semi-infinite water-filled pipes. The vibration characteristics of the coupled system under the excitation of mechanical forces and fluid-borne forces at the pump are calculated. The results enhance our understanding about how the input mechanical and fluid excitation energy at the pump is transmitted to the pipes and how to relate the piping vibroacoustical response to the excitations at the pump. This study assists in predicting dynamic stress in pipes for given excitations at the pump, and in developing methods to identify the nature (fluid or mechanical) of the excitation forces at the pump using the vibration and dynamic pressure measurements on the pump/pipe system.

  2. How the factoid of wind turbines causing 'vibroacoustic disease' came to be 'irrefutably demonstrated'.

    Science.gov (United States)

    Chapman, Simon; St George, Alexis

    2013-06-01

    In recent years, claims have proliferated in cyberspace that wind turbines cause a large variety of symptoms and diseases. One of these, "vibroacoustic disease" (VAD) is frequently mentioned. The aim of this study is to examine the quality of the evidence on how VAD came to be associated with wind turbine exposure by wind farm opponents. Searches of the web (Google advanced) and major research databases for papers on VAD and wind turbines. Self-citation analysis of research papers on VAD. Google returned 24,700 hits for VAD and wind turbines. Thirty-five research papers on VAD were found, none reporting any association between VAD and wind turbines. Of the 35 papers, 34 had a first author from a single Portuguese research group. Seventy-four per cent of citations to these papers were self-citations by the group. Median self-citation rates in science are around 7%. Two unpublished case reports presented at conferences were found asserting that VAD was "irrefutably demonstrated" to be caused by wind turbines. The quality of these reports was abject. VAD has received virtually no scientific recognition beyond the group who coined and promoted the concept. There is no evidence of even rudimentary quality that vibroacoustic disease is associated with or caused by wind turbines. The claim that wind turbines cause VAD is a factoid that has gone 'viral' in cyberspace and may be contributing to nocebo effects among those living near turbines. © 2013 The Authors. ANZJPH © 2013 Public Health Association of Australia.

  3. Vibro-Acoustic Numerical Analysis for the Chain Cover of a Car Engine

    Directory of Open Access Journals (Sweden)

    Enrico Armentani

    2017-06-01

    Full Text Available In this work, a vibro-acoustic numerical and experimental analysis was carried out for the chain cover of a low powered four-cylinder four-stroke diesel engine, belonging to the FPT (FCA Power Train family called SDE (Small Diesel Engine. By applying a methodology used in the acoustic optimization of new FPT engine components, firstly a finite element model (FEM of the engine was defined, then a vibration analysis was performed for the whole engine (modal analysis, and finally a forced response analysis was developed for the only chain cover (separated from the overall engine. The boundary conditions applied to the chain cover were the accelerations experimentally measured by accelerometers located at the points of connection among chain cover, head cover, and crankcase. Subsequently, a boundary element (BE model of the only chain cover was realized to determine the chain cover noise emission, starting from the previously calculated structural vibrations. The numerical vibro-acoustic outcomes were compared with those experimentally observed, obtaining a good correlation. All the information thus obtained allowed the identification of those critical areas, in terms of noise generation, in which to undertake necessary improvements.

  4. Vibroacoustic Impact on the Architectonic Heritage When Using Replicas of 16th Century Weapons.

    Science.gov (United States)

    Lloret, Angel Tomas; Sendra, Sandra; Lloret, Jaime; Del Rey, Romina; Louis Cereceda, Miguel

    2017-08-14

    The recreation of historical battles next to old buildings, walls, churches, fortifications or historical facades belonging to the historical heritage of a city, has always been a source of controversy and discussion. In the absence of a clear legislation about how these buildings can be affected by the use of blunderbusses and pyrotechnics, it is necessary to carry out practical experiments to test the effect of these celebrations on these buildings. For this reason, this paper presents a set of practical experiments where the vibroacoustic effect of using weapons such as blunderbusses and harquebuses is analyzed. To gather these measurements, we have used several sound level meters and 3-axis accelerometers placed on the facade of an old building. The tests have been carried out at the Moors and Christians festival of Villajoyosa (Spain) which is internationally famous for this festival. In order to carry out the tests, six harquebusiers shot their firearms and the sensors placed along the facade of the building at different height collected the data. The results of these devices allow us to study the vibroacoustic impact on the facade depending on the height.

  5. Vibro-Acoustic Modulation Based Damage Identification in a Composite Skin-Stiffener Structure

    Science.gov (United States)

    Ooijevaar, T. H.; Loendersloot, R.; Rogge, M. D.; Akkerman, R.; Tinga, T.

    2014-01-01

    The vibro-acoustic modulation method is applied to a composite skin-stiffener structure to investigate the possibilities to utilize this method for damage identification in terms of detection, localisation and damage quantification. The research comprises a theoretical part and an experimental part. An impact load is applied to the skin-stiffener structure, resulting in a delamination underneath the stiffener. The structure is interrogated with a low frequency pump excitation and a high frequency carrier excitation. The analysis of the response in a frequency band around the carrier frequency is employed to assess the damage identification capabilities and to gain a better understanding of the modulations occurring and the underlying physical phenomena. Though vibro-acoustic is shown to be a sensitive method for damage identification, the complexity of the damage, combined with a high modal density, complicate the understanding of the relation between the physical phenomena and the modulations occurring. more research is recommended to reveal the physics behind the observations.

  6. Vibroacoustic response of panels under diffuse acoustic field excitation from sensitivity functions and reciprocity principles.

    Science.gov (United States)

    Marchetto, Christophe; Maxit, Laurent; Robin, Olivier; Berry, Alain

    2017-06-01

    This paper aims at developing an experimental method to characterize the vibroacoustic response of a panel to a diffuse acoustic field (DAF) excitation with a different laboratory setup than those used in standards (i.e., coupled rooms). The proposed methodology is based on a theoretical model of the DAF and on the measurement of the panel's sensitivity functions, which characterize its vibroacoustic response to wall plane waves. These functions can be estimated experimentally using variations of the reciprocity principle, which are described in the present paper. These principles can either be applied for characterizing the structural response by exciting the panel with a normal force at the point of interest or for characterizing the acoustic response (radiated pressure, acoustic intensity) by exciting the panel with a monopole and a dipole source. For both applications, the validity of the proposed approach is numerically and experimentally verified on a test case composed of a baffled simply supported plate. An implementation for estimating the sound transmission loss of the plate is finally proposed. The results are discussed and compared with measurements performed in a coupled anechoic-reverberant room facility following standards.

  7. Active vibration and noise control of vibro-acoustic system by using PID controller

    Science.gov (United States)

    Li, Yunlong; Wang, Xiaojun; Huang, Ren; Qiu, Zhiping

    2015-07-01

    Active control simulation of the acoustic and vibration response of a vibro-acoustic cavity of an airplane based on a PID controller is presented. A full numerical vibro-acoustic model is developed by using an Eulerian model, which is a coupled model based on the finite element formulation. The reduced order model, which is used to design the closed-loop control system, is obtained by the combination of modal expansion and variable substitution. Some physical experiments are made to validate and update the full-order and the reduced-order numerical models. Optimization of the actuator placement is employed in order to get an effective closed-loop control system. For the controller design, an iterative method is used to determine the optimal parameters of the PID controller. The process is illustrated by the design of an active noise and vibration control system for a cavity structure. The numerical and experimental results show that a PID-based active control system can effectively suppress the noise inside the cavity using a sound pressure signal as the controller input. It is also possible to control the noise by suppressing the vibration of the structure using the structural displacement signal as the controller input. For an airplane cavity structure, considering the issue of space-saving, the latter is more suitable.

  8. Computational Vibroacoustics in Low- and Medium- Frequency Bands: Damping, ROM, and UQ Modeling

    Directory of Open Access Journals (Sweden)

    Roger Ohayon

    2017-06-01

    Full Text Available Within the framework of the state-of-the-art, this paper presents a summary of some common research works carried out by the authors concerning computational methods for the prediction of the responses in the frequency domain of general linear dissipative vibroacoustics (structural-acoustic systems for liquid and gas in the low-frequency (LF and medium-frequency (MF domains, including uncertainty quantification (UQ that plays an important role in the MF domain. The system under consideration consists of a deformable dissipative structure, coupled with an internal dissipative acoustic fluid including a wall acoustic impedance, and surrounded by an infinite acoustic fluid. The system is submitted to given internal and external acoustic sources and to prescribed mechanical forces. An efficient reduced-order computational model (ROM is constructed using a finite element discretization (FEM for the structure and the internal acoustic fluid. The external acoustic fluid is treated using a symmetric boundary element method (BEM in the frequency domain. All the required modeling aspects required for the analysis in the MF domain have been introduced, in particular the frequency-dependent damping phenomena and model uncertainties. An industrial application to a complex computational vibroacoustic model of an automobile is presented.

  9. The efficiency of neurometabolic therapy in the prevention of arterial hypertension in workers of vibroacoustic professions of aircraft enterprises

    Directory of Open Access Journals (Sweden)

    Сергій Геннадійович Сова

    2015-04-01

    Full Text Available The article is dedicated to the problem of arterial hypertension, including hypertensive crisis prevention in aircraft enterprises’ workers of vibroacoustic professions. The article studies the influence of neurometabolic pharmaceutical medicine Vinpocetine on the course and prognosis of hypertension.Methods. Using the routine methods of cardiac patients’ clinical study we examined 63 persons delivered in an emergency to the inpatient units of the occupational diseases clinics with the diagnosis of "uncomplicated hypertensive crisis." The main group includes aircraft enterprises’ workers of vibroacoustic professions (n = 31 who were administered according to a therapeutic complex scheme the neurometabolic medicine Vinpocetine at a dose of 30-40 mg per day. The control group consists of the workers (n = 32 who didn’t encounter with vibroacoustic factor during their working activity and didn’t get any neurometabolic medicines according to the complex scheme of treatment.Results. The survey results have demonstrated the comparability of working groups by age, sex, main modifiable factors of cardiovascular risk, hemodynamic characteristics and cognitive abilities. Introduction of Vinpocetine into the scheme of treatment of vibroacoustic professions’ workers made it possible to achieve more significant, compared to control, decrease in blood pressure and the rates of hypertensive crises recurrence in the long-term dynamics, as well as improvement in left ventricular diastolic function of the heart and the significant increase in the scale of cognitive function data at the fifth month of observation (p<0,05.Conclusions. Using Vinpocetine can significantly improve the course and prognosis of hypertension among aircraft enterprises’ workers of vibroacoustic professions

  10. Evaluation of the effectiveness of vibroacoustic therapy treatment of patients with so-called "heel spur". A preliminary report.

    Science.gov (United States)

    Łukasiak, Adam; Krystosiak, Monika; Widłak, Patrycja; Woldańska-Okońska, Marta

    2013-01-01

    The so-called "heel spur" is a radiological term referring to adaptive bone growth as a result of chronic overload enthesopathy of the proximal attachment of the plantar fascia. The main cause of the pain is continued localised pressure on the surrounding soft tissues. Vibroacoustic wave therapy is a relatively new method gaining popularity among doctors, physiotherapists and patients. The aim of this study was to confirm the clinical efficacy of vibroacoustic therapy compared to laser and ultrasound therapy. The study enrolled 60 patients treated for plantar heel spurs who were divided into a study group of 40 patients who underwent vibroacoustic therapy and a control group of 20 patients treated with ultrasound and laser therapy. The outcome measure for evaluating the effectiveness of physiotherapy was a subjective assessment of pain intensity by VAS and the modified short-form McGill Pain Questionnaire. The mean pain intensity score in patients undergoing vibroacoustic therapy decreased by about 2.6 points according to the VAS scale and 17 points according to the McGill questionnaire, compared to reductions of 0.6 and 6 points, respectively, in the ultrasound and laser therapy group. The correlation between subjective assessment of pain according to the VAS scale and palpation-based assessment of pain was significantly positive between the two groups, demonstrating similarity of the two scales, with a slight dominance of the group undergoing laser and ultrasound therapy. These results represent a tentative confirmation of analgesic effectiveness of the vibro-acoustic method in musculoskeletal overload conditions. 2. In order to confirm its effectiveness, it is necessary to conduct further prospective randomized studies with blinding and evaluate the long-term results.

  11. Non-invasive, photonics-based diagnostic, imaging, monitoring, and light delivery techniques for the recognition, quantification and treatment of malignant and chronic inflammatory conditions

    Science.gov (United States)

    Davies, N.; Davies-Shaw, D.; Shaw, J. D.

    2007-02-01

    We report firsthand on innovative developments in non-invasive, biophotonic techniques for a wide range of diagnostic, imaging and treatment options, including the recognition and quantification of cancerous, pre-cancerous cells and chronic inflammatory conditions. These techniques have benefited from the ability to target the affected site by both monochromatic light and broad multiple wavelength spectra. The employment of such wavelength or color-specific properties embraces the fluorescence stimulation of various photosensitizing drugs, and the instigation and detection of identified fluorescence signatures attendant upon laser induced fluorescence (LIF) phenomena as transmitted and propagated by precancerous, cancerous and normal tissue. In terms of tumor imaging and therapeutic and treatment options, we have exploited the abilities of various wavelengths to penetrate to different depths, through different types of tissues, and have explored quantifiable absorption and reflection characteristics upon which diagnostic assumptions can be reliably based and formulated. These biophotonic-based diagnostic, sensing and imaging techniques have also benefited from, and have been further enhanced by, the integrated ability to provide various power levels to be employed at various stages in the procedure. Applications are myriad, including non-invasive, non destructive diagnosis of in vivo cell characteristics and functions; light-based tissue analysis; real-time monitoring and mapping of brain function and of tumor growth; real time monitoring of the surgical completeness of tumor removal during laser-imaged/guided brain resection; diagnostic procedures based on fluorescence life-time monitoring, the monitoring of chronic inflammatory conditions (including rheumatoid arthritis), and continuous blood glucose monitoring in the control of diabetes.

  12. On-Line Monitoring and Diagnostics of the Integrity of Nuclear Plant Steam Generators and Heat Exchangers, Volumes 1, 2

    Energy Technology Data Exchange (ETDEWEB)

    Upadhyaya, Belle R. [Univ. of Tennessee, Knoxville, TN (United States); Hines, J. Wesley [Univ. of Tennessee, Knoxville, TN (United States); Lu, Baofu [Univ. of Tennessee, Knoxville, TN (United States)

    2005-06-03

    The overall purpose of this Nuclear Engineering Education Research (NEER) project was to integrate new, innovative, and existing technologies to develop a fault diagnostics and characterization system for nuclear plant steam generators (SG) and heat exchangers (HX). Issues related to system level degradation of SG and HX tubing, including tube fouling, performance under reduced heat transfer area, and the damage caused by stress corrosion cracking, are the important factors that influence overall plant operation, maintenance, and economic viability of nuclear power systems. The research at The University of Tennessee focused on the development of techniques for monitoring process and structural integrity of steam generators and heat exchangers. The objectives of the project were accomplished by the completion of the following tasks. All the objectives were accomplished during the project period. This report summarizes the research and development activities, results, and accomplishments during June 2001 September 2004. Development and testing of a high-fidelity nodal model of a U-tube steam generator (UTSG) to simulate the effects of fouling and to generate a database representing normal and degraded process conditions. Application of the group method of data handling (GMDH) method for process variable prediction. Development of a laboratory test module to simulate particulate fouling of HX tubes and its effect on overall thermal resistance. Application of the GMDH technique to predict HX fluid temperatures, and to compare with the calculated thermal resistance.Development of a hybrid modeling technique for process diagnosis and its evaluation using laboratory heat exchanger test data. Development and testing of a sensor suite using piezo-electric devices for monitoring structural integrity of both flat plates (beams) and tubing. Experiments were performed in air, and in water with and without bubbly flow. Development of advanced signal processing methods using

  13. Diagnostic value of diffusion-weighted MRI for tumor characterization, differentiation and monitoring in pediatric patients with neuroblastic tumors

    Energy Technology Data Exchange (ETDEWEB)

    Neubauer, Henning [Univ. Hospital Ulm (Germany). Dept. of Diagnostic and Interventional Radiology; Univ. Hospital Wuerzburg (Germany). Dept. of Diagnostic and Interventional Radiology; Li, Mengxia [Univ. Hospital Wuerzburg (Germany). Dept. of Radiation Oncology; Mueller, Verena Rabea [Univ. Hospital Wuerzburg (Germany). Dept. of Paediatrics; Pabst, Thomas [Univ. Hospital Wuerzburg (Germany). Dept. of Diagnostic and Interventional Radiology; Beer, Meinrad [Univ. Hospital Ulm (Germany). Dept. of Diagnostic and Interventional Radiology

    2017-07-15

    We explored the diagnostic value of diffusion-weighted MRI (DWI) for tumor characterization, differentiation and therapy monitoring in pediatric patients with extracranial neuroblastic tumors. All 29 patients (14 girls, median age: 3 years) with neuroblastoma (NB, n = 19), ganglioneuroblastoma (GNB, n = 4) and ganglioneuroma (GN, n = 6) who had had at least one in-house DWI examination since 2005 were identified and retrospectively analyzed. Two independent blinded readers measured ADC values (unit: 10-3 mm{sup 2}/s) and signal intensity ratios (SIRs) of the primary tumor and, if applicable, of the tumor after chemotherapy, metastases and tumor relapse. The pre-treatment ADC was 0.90 ± 0.23 in NB/GNB and 1.70 ± 0.36 in GN without overlap between the two entities for both readers, 0.67 ± 0.14 in metastases and 0.72 ± 0.18 in tumor relapse. With chemotherapy, mean ADC increased to 1.54 ± 0.33 in NB/GNB and to 1.23 ± 0.27 in metastases (p < 0.05). The median SIRs of various tumor lesions vs. liver, vs. muscle tissue and vs. adjacent tissue were significantly higher on DWI (range: 2.4 -9.9) than on ce-T1w (range: 1.0 - 1.8, all p < 0.05). The coefficient of variation (CV) was ≤ 8.0% for ADC and ≤ 16.4% for signal intensity data. Based on mean ADC, DWI distinguishes between NB/GNB and GN with high certainty and provides plausible quantitative data on tumor response to therapy. Lesion conspicuity, as measured by SIR, is superior on DWI, compared to ce-T1w. DWI as a noninvasive, radiation-free and widely available imaging technique should be an integral part of MR imaging for neuroblastic tumors and should undergo prospective evaluation in multicenter studies.

  14. Wireless Infrastructure for Performing Monitoring, Diagnostics, and Control HVAC and Other Energy-Using Systems in Small Commercial Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Patrick O' Neill

    2009-06-30

    This project focused on developing a low-cost wireless infrastructure for monitoring, diagnosing, and controlling building systems and equipment. End users receive information via the Internet and need only a web browser and Internet connection. The system used wireless communications for: (1) collecting data centrally on site from many wireless sensors installed on building equipment, (2) transmitting control signals to actuators and (3) transmitting data to an offsite network operations center where it is processed and made available to clients on the Web (see Figure 1). Although this wireless infrastructure can be applied to any building system, it was tested on two representative applications: (1) monitoring and diagnostics for packaged rooftop HVAC units used widely on small commercial buildings and (2) continuous diagnosis and control of scheduling errors such as lights and equipment left on during unoccupied hours. This project developed a generic infrastructure for performance monitoring, diagnostics, and control, applicable to a broad range of building systems and equipment, but targeted specifically to small to medium commercial buildings (an underserved market segment). The proposed solution is based on two wireless technologies. The first, wireless telemetry, is used for cell phones and paging and is reliable and widely available. This risk proved to be easily managed during the project. The second technology is on-site wireless communication for acquiring data from sensors and transmitting control signals. The technology must enable communication with many nodes, overcome physical obstructions, operate in environments with other electrical equipment, support operation with on-board power (instead of line power) for some applications, operate at low transmission power in license-free radio bands, and be low cost. We proposed wireless mesh networking to meet these needs. This technology is relatively new and has been applied only in research and tests

  15. On-Line Monitoring and Diagnostics of the Integrity of Nuclear Plant Steam Generators and Heat Exchangers.

    Energy Technology Data Exchange (ETDEWEB)

    Belle R. Upadhyaya; J. Wesley Hines

    2004-09-27

    The overall purpose of this Nuclear Engineering Education Research (NEER) project was to integrate new, innovative, and existing technologies to develop a fault diagnostics and characterization system for nuclear plant steam generators (SG) and heat exchangers (HX). Issues related to system level degradation of SG and HX tubing, including tube fouling, performance under reduced heat transfer area, and the damage caused by stress corrosion cracking, are the important factors that influence overall plant operation, maintenance, and economic viability of nuclear power systems. The research at The University of Tennessee focused on the development of techniques for monitoring process and structural integrity of steam generators and heat exchangers. The objectives of the project were accomplished by the completion of the following tasks. All the objectives were accomplished during the project period. This report summarizes the research and development activities, results, and accomplishments during June 2001-September 2004. (1) Development and testing of a high-fidelity nodal model of a U-tube steam generator (UTSG) to simulate the effects of fouling and to generate a database representing normal and degraded process conditions. Application of the group method of data handling (GMDH) method for process variable prediction. (2) Development of a laboratory test module to simulate particulate fouling of HX tubes and its effect on overall thermal resistance. Application of the GMDH technique to predict HX fluid temperatures, and to compare with the calculated thermal resistance. (3) Development of a hybrid modeling technique for process diagnosis and its evaluation using laboratory heat exchanger test data. (4) Development and testing of a sensor suite using piezo-electric devices for monitoring structural integrity of both flat plates (beams) and tubing. Experiments were performed in air, and in water with and without bubbly flow. (5) Development of advanced signal

  16. Effect of LCD monitor type and observer experience on diagnostic performance in soft-copy interpretations of the maxillary sinus on panoramic radiographs

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Tae Young; Choi, Jin Woo; Lee, Sam Sun; Huh, Kyung Hoe; Yi, Won Jin; Heo, Min Suk; Choi, Soon Chul [School of Dentistry, Seoul National University, Seoul (Korea, Republic of)

    2011-03-15

    The aim of this study was to evaluate the effect of liquid crystal display (LCD) monitor type and observer experience on the diagnostic performance in soft-copy interpretations of maxillary sinus inflammatory lesions on panoramic radiographs. Ninety maxillary sinuses on panoramic images were grouped into negative and positive groups according to the presence of inflammatory lesions, using CT for confirmation. Monochrome and color LCDs were used. Six observers participated and ROC analysis was performed to evaluate the diagnostic performance. The reading time, fatigue score, and inter-/intra-observer agreements were assessed. The interpretation of maxillary sinus inflammatory lesions was affected by the LCD monitor type used and by the experience of the observer. The reading time was not significantly different, however the fatigue score was significantly different between two LCD monitors. Inter-observer agreement was relatively good in experienced observers, while the intra-observer agreement for all observers was good with monochrome LCD but not with color LCD. The less experienced observers showed lowered diagnostic ability with a general color LCD.

  17. Effect of LCD monitor type and observer experience on diagnostic performance in soft-copy interpretations of the maxillary sinus on panoramic radiographs.

    Science.gov (United States)

    Kim, Tae-Young; Choi, Jin-Woo; Lee, Sam-Sun; Huh, Kyung-Hoe; Yi, Won-Jin; Heo, Min-Suk; Choi, Soon-Chul

    2011-03-01

    The aim of this study was to evaluate the effect of liquid crystal display (LCD) monitor type and observer experience on the diagnostic performance in soft-copy interpretations of maxillary sinus inflammatory lesions on panoramic radiographs. Ninety maxillary sinuses on panoramic images were grouped into negative and positive groups according to the presence of inflammatory lesions, using CT for confirmation. Monochrome and color LCDs were used. Six observers participated and ROC analysis was performed to evaluate the diagnostic performance. The reading time, fatigue score, and inter-/intra-observer agreements were assessed. The interpretation of maxillary sinus inflammatory lesions was affected by the LCD monitor type used and by the experience of the observer. The reading time was not significantly different, however the fatigue score was significantly different between two LCD monitors. Inter-observer agreement was relatively good in experienced observers, while the intra-observer agreement for all observers was good with monochrome LCD but not with color LCD. The less experienced observers showed lowered diagnostic ability with a general color LCD.

  18. Soft-Copy Reading in Digital Mammography of Microcalcifications: Diagnostic Performance of a 5-Megapixel Cathode Ray Tube Monitor versus a 3-Megapixel Liquid Crystal Display Monitor in a Clinical Setting

    Energy Technology Data Exchange (ETDEWEB)

    Uematsu, T.; Kasami, M.; Uchida, Y. [Dept. of Diagnostic Radiology, Dept. of Pathology, and Breast Center, Shizuoka Cancer Center Hospital, Shizuoka (Japan)

    2007-09-15

    Background: A recent study using dedicated contrast-detail phantoms showed that the image quality of a 3-megapixel (M) monitor can approach that of a 5M monitor in digital mammography. Purpose: To compare a 5M cathode ray tube (CRT) monitor with a 3M liquid crystal display (LCD) monitor for soft-copy reading of digital mammography of microcalcifications in a clinical setting. Material and Methods: 100 screen-detected microcalcification lesions (34 malignant and 66 benign) without mass that had been evaluated with 11-gauge stereotactic vacuum-assisted breast biopsy or definitive surgery were recruited into the study. One radiologist analyzed the soft-copy mammograms on a 5M CRT monitor and a 3M LCD monitor with 5 months between interpretations and scored the likelihood of malignancy and calcification distribution on a five-point scale. Calcification morphology and breast density were scored on a four-point scale. Positive predictive value (PPV) and negative predictive value (NPV) were calculated on the basis of a Breast Imaging Reporting and Data System. The interpretation time was also measured. Results: There was no significant difference in the likelihood of malignancy (P = 0.655), calcification morphology (P = 0.168), calcification distribution (P = 0.11), and breast density (P = 0.0608). The PPV and NPV of soft-copy reading on the 5M CRT monitor was 57% (30/53) and 91% (43/47), respectively, identical to the results using the 3M LCD monitor. The total interpretation time averaged 88 s for the 5M CRT monitor and 67 s for the 3M LCD monitor (P<0.0001). Conclusion: Soft-copy reading of a digital mammography of microcalcifications with a 3M LCD monitor was similar in diagnostic performance to a 5M CRT monitor in this study.

  19. Effect of maternal stress on fetal heart rate assessed by vibroacoustic stimulation.

    Science.gov (United States)

    Makino, I; Matsuda, Y; Yoneyama, M; Hirasawa, K; Takagi, K; Ohta, H; Konishi, Y

    2009-01-01

    This study was designed to determine whether maternal stress levels, state and trait anxiety levels, and stress hormones affect fetal heart rate (FHR) patterns after vibroacoustic stimulation (VAS) at 30 weeks of gestation. A total of 24 healthy pregnant women with a single fetus pregnancy were enrolled. Corticotropin releasing hormone (CRH) and adrenocorticotropic hormone in maternal plasma and cortisol, and chromogranin A in saliva were measured. The FHR patterns after VAS were divided into three types: type I, a long period of acceleration or one acceleration lasting > 1 min or at least two accelerations lasting > 15 s; type II, a biphasic response with acceleration followed by deceleration; and type III, no response or prolonged deceleration. In the high trait anxiety group, CRH levels were significantly higher than in the low trait anxiety group, and FHR patterns after VAS showed mostly a type II response pattern. These findings suggest that stress in pregnant women with high trait anxiety may influence FHR patterns after VAS.

  20. Vibroacoustic Analysis of Cyclic Structures by Using Dof’s Size Reduction and Holographic Measurements

    Directory of Open Access Journals (Sweden)

    Abdelkhalak El Hami

    2006-01-01

    Full Text Available We propose a method for the vibroacoustic analysis of structures having symmetry properties. This method is based on the reduction of the number of the degrees of freedom involved (size reduction and the use of experimental data (confrontation numerical/experimental. We propose the extension of the method of the linear representations of finite symmetry groups to problems of coupling fluid-structure. This approach, while keeping the quality of the approximations, leads to a significant reduction of the number of degrees of freedom, with a maximal reduction for the so called repetitive structures. Finally, we present a practical case of modal analysis – in air and water – of a ship propeller formed by 3 stainless steel blades. The experimental results are obtained by using the whole-field, non-contact technique of electronic holography.

  1. Effects of vibroacoustic stimulation in music therapy for palliative care patients: a feasibility study.

    Science.gov (United States)

    Warth, Marco; Kessler, Jens; Kotz, Svenja; Hillecke, Thomas K; Bardenheuer, Hubert J

    2015-12-15

    The present study aimed at examining whether methodological strategies from a previously implemented study design could be transferred to the evaluation of the psychological and physiological effects of a music therapy intervention working with vibroacoustic stimulation in palliative care. Nine participants suffering from advanced cancer took part in single-sessions of music therapy, lasting for 30 min. The live music therapy intervention utilized singing chair sounds and vocal improvisation. Visual analogue scales (VAS) were used to assess self-ratings of pain, relaxation, and well-being before and after each session. During the intervention, we continuously recorded heart rate variability (HRV) as a measure of autonomic functioning. Data collection was complemented by a semi-structured interview to explore subjective experiences in more detail. Feasibility was defined as the ability to complete 80 % of the sessions in accordance with the study protocol. In 5 out of 9 sessions (55 %) it was possible to deliver the intervention and obtain all data as intended. VAS assessment was feasible, although graphical and statistical examination revealed only marginal mean changes between pre and post. HRV recordings were subject to artifacts. While HRV parameters differed between individuals, mean changes over time remained relatively constant. Interview data confirmed that the individual perception was very heterogeneous, ranging from "calming" to "overwhelming". The criterion of feasibility was not met in this study. Physiological data showed high attrition rates, most likely due to movement artifacts and reduced peripheral blood flow in some participants' extremities. Examination of individual-level trajectories revealed that vibroacoustic stimulation may have an impact on the autonomic response. However, the direction and mechanisms of effects needs to be further explored in future studies. German Clinical Trials Register - DRKS00006137 (July 4(th), 2014).

  2. The influence of vibroacoustic therapy on the functional status of patients with gonarthrosis. A preliminary report

    Directory of Open Access Journals (Sweden)

    Agnieszka Skopowska

    2014-11-01

    Full Text Available Aim of the study: Gonarthrosis is a degenerative disease of the articular cartilage. Its main symptoms are pain, swelling, stiffness, limitation of functions and deformations of the joint. One of the available methods of preservative treatment of gonarthrosis is vibroacoustic therapy (VT, which evokes micro-vibrations in the tissues – through the use of sound waves of variable frequency and amplitude. The aim of the study was to estimate the influence of VT on the functional status of people with gonarthrosis. Material and methods: Forty-four people, aged over 44, with gonarthrosis were subjected to 10 sessions of VT with the Vitafon-T device, in a variable range of frequencies between 30 and 18 000 Hz. The sessions lasted 15 minutes. In order to estimate the effectiveness of the therapy, double measurements (before and after therapy of the following parameters were taken: pain (VAS, joint circumferences and function tests (Timed Up and Go – TUG, the average free walking time at the 6 m distance and the knee bends test. The statistical analysis was carried out using the Wilcoxon test, with the significance level of p < 0.0001. Results : In the examined group a decrease was observed in: pain (by 1.9 VAS points among 77% of the patients, circumference of the joints among 91% and the time of conducting the TUG test in 96%. The number of knee bends increased in 82% of the patients. All the results reached statistical significance (p < 0.0001. The free walking improved among 91%; however, this result was not statistically significant. Conclusions : Vibroacoustic therapy has brought positive treatment effects of an analgesic and anti-swelling character, which has further influenced the functional efficiency of the patients with gonarthrosis. The research still needs to be expanded to other groups of patients before the method may be popularized in primary care rehabilitation facilities.

  3. Regularities of filtration of sunflower oil with the use of vibroacoustic exposure

    Directory of Open Access Journals (Sweden)

    S. A. Bredikhin

    2017-01-01

    Full Text Available The residue in sunflower oil is a dispersed phase consisting of particulate products grinding sunflower seeds in the form of particles of the pulp, oil cake, meal, residual quantities of metals, pesticides. In the recycling process they are in the oil in suspension and negatively affect its quality. For research an experimental setup was developed allowing to change the angle of inclination of the filter element. The regularities of filtration were determined without preliminary purification of sunflower oil by centrifugation and after centrifugation. It is established, the contamination of centrifuged oil in the initial period is 14.6 times lower. After 10 minutes of treatment, it decreases by 62%, after 20 minutes – by 79.4%. With a 30-minute treatment, particles of 0.005-0.1 mm in size are removed to 90%, which is approximated to the refined oil in terms of contamination. The influence of vibration-acoustic action on sunflower oil during its filtration is shown. At the last stage of production, the peroxide index is reduced to 2-3 moles of active oxygen, and after 3 months of storage – from 11.8 to 7.7, which according to GOST corresponds to the highest-grade oil. The regularities of the filtration without pre-treatment of sunflower oil by centrifugation and after centrifugation. Shows the effect of vibroacoustic exposure on sunflower oil when filtering. The obtained data on the change of qualitative parameters of sunflower oil during its filtration in the field of vibroacoustic impact.

  4. Initial Assessment of the Ares I-X Launch Vehicle Upper Stage to Vibroacoustic Flight Environments

    Science.gov (United States)

    Larko, Jeffrey M.; Hughes, William O.

    2008-01-01

    The Ares I launch vehicle will be NASA s first new launch vehicle since 1981. Currently in design, it will replace the Space Shuttle in taking astronauts to the International Space Station, and will eventually play a major role in humankind s return to the Moon and eventually to Mars. Prior to any manned flight of this vehicle, unmanned test readiness flights will be flown. The first of these readiness flights, named Ares I-X, is scheduled to be launched in April 2009. The NASA Glenn Research Center is responsible for the design, manufacture, test and analysis of the Ares I-X upper stage simulator (USS) element. As part of the design effort, the structural dynamic response of the Ares I-X launch vehicle to its vibroacoustic flight environments must be analyzed. The launch vehicle will be exposed to extremely high acoustic pressures during its lift-off and aerodynamic stages of flight. This in turn will cause high levels of random vibration on the vehicle's outer surface that will be transmitted to its interior. Critical flight equipment, such as its avionics and flight guidance components are susceptible to damage from this excitation. This study addresses the modelling, analysis and predictions from examining the structural dynamic response of the Ares I-X upper stage to its vibroacoustic excitations. A statistical energy analysis (SEA) model was used to predict the high frequency response of the vehicle at locations of interest. Key to this study was the definition of the excitation fields corresponding to lift off acoustics and the unsteady aerodynamic pressure fluctuations during flight. The predicted results will be used by the Ares I-X Project to verify the flight qualification status of the Ares I-X upper stage components.

  5. Development of diagnostic concentrations for insecticide resistance monitoring in soybean looper (Lepidoptera: Noctuidae) larvae using an artificial diet overlay bioassay.

    Science.gov (United States)

    Mascarenhas, R N; Boethel, D J

    2000-06-01

    Diagnostic concentrations for several standard and experimental insecticides were determined for a laboratory reference strain of soybean looper, Pseudoplusia includens (Walker), using an insecticide diet overlay bioassay to evaluate the relative susceptibility of field (P) and F1 generations of four field-collected strains of third-, fourth-, and fifth-instar soybean loopers in 1996 and 1997. Diagnostic concentrations were defined as concentrations that killed 90-95% of the susceptible individuals and were 5 ppm for permethrin, 1,300 ppm for thiodicarb, 60 ppm for chlorfenapyr, 5 ppm for emamectin benzoate, and 60 ppm for spinosad. Field strains exhibited significantly greater percentage survival than the laboratory reference strain in the permethrin bioassays in 1996 and 1997 in both the P and F1 generation bioassays and in the thiodicarb bioassays in 1997. Larvae exposed to diagnostic concentrations of the experimental insecticides chlorfenapyr, emamectin benzoate, and spinosad usually did not exhibit significantly higher percentage survival than the reference strain.

  6. Research and development program in reactor diagnostics and monitoring with neutron noise methods. Stage 7. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Pazsit, I.; Demaziere, C.; Arzhanov, V. [Chalmers Univ. of Technology, Goeteborg (Sweden). Department of Reactor Physics; Garis, N.S. [Swedish Nuclear Power Inspectorate, Stockholm (Sweden)

    2001-08-01

    This report constitutes stage 7 of a long-term research and development program concerning the development of diagnostics and monitoring methods for nuclear reactors. A proposal for the continuation of this program in stage 8 is also given at the end of the report. In stage 6, the basic principles of a 3-D fully coupled neutronic/thermal-hydraulic simulator in the frequency domain were presented. The neutronic model relied on the two-group diffusion approximation, whereas the thermal-hydraulic algorithms relied on the so called 'lumped' model. The key element of this simulator was that only the static data were required which could be obtained from the Studsvik Scandpower CASMO-4/TABLES-3/ SIMULATE-3 code package. The simulator was developed with this underlying idea, which means that the calculation of the static fluxes and the eigenvalue were avoided. Depending on what kind of spatial discretization scheme which is used in the noise simulator to calculate the 'leakage' noise, it is not granted that the system remains critical by using the group constants supplied by SIMULATE. Nevertheless, when the system is critical, the balance equations should be fulfilled in all nodes with respect to the discretization scheme used. In concrete terms, the calculation of the static fluxes and eigenvalue can be avoided if the system is brought back to criticality by modifying the cross-sections so that the balance equations are always fulfilled with the chosen spatial discretization scheme. This approach was used in this study with the finite difference scheme. As pointed out in stage 6, the finite difference scheme is relatively inefficient compared to finite elements or nodal methods, but on the other hand it is rather easy to implement. These two more sophisticated schemes are planned to be investigated at a later stage, but for the time being the simulator relying on the finite difference scheme was improved as much as possible so that a 2-D entirely

  7. Diagnostic performance in differentiation of breast lesion on digital mammograms: comparison among hard-copy film, 3-megapixel LCD monitor, and 5-megapixel LCD monitor.

    Science.gov (United States)

    Kamitani, Takeshi; Yabuuchi, Hidetake; Matsuo, Yoshio; Setoguchi, Taro; Sakai, Shuji; Okafuji, Takashi; Sunami, Shunya; Hatakenaka, Masamitsu; Ishii, Nobuhide; Kubo, Makoto; Tokunaga, Eriko; Yamamoto, Hidetaka; Honda, Hiroshi

    2011-01-01

    We compared observer performance of digital mammography among hard-copy readings and soft-copy readings using 3-megapixel (3M) and 5-megapixel (5M) liquid crystal display (LCD) monitors. Five experienced radiologists assessed 80 mammograms of 40 cancers and 40 benign lesions. There were no significant differences among the average A(z) of three modalities and among the κ values for intra- and interobserver agreement. The soft-copy reading using the 3M LCD monitor took a slightly longer time, although there were no significant differences. Copyright © 2011 Elsevier Inc. All rights reserved.

  8. Research and Development Program in Reactor Diagnostics and Monitoring with Neutron Noise Methods. Stage 11 and 12. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Sunde, C.; Pazsit, I.; Demaziere, C.; Dahl, O.; Mileshina, L. [Chalmers Univ. of Technology, Goeteborg (Sweden). Dept. of Nuclear Engineering

    2006-06-15

    This report describes the results obtained during Stage 11 and 12 of a long-term research and development program concerning the development of diagnostics and monitoring methods for nuclear reactors. The long-term goals are elaborated in more detail in e.g. the Final Reports of stage 1 and 2 (SKI Report 95:14 and 96:50). Higher order eigenfunctions and eigenvalues of the diffusion equation, describing a static core, have lost their significance when doing calculations in realistic systems, since there are usually made by nodal methods or other direct numerical techniques. However, there are situations when knowledge of the higher order modes is still useful. Such case is the separation of the global and regional flux oscillations in the case of BWR instability. Another case is the investigation of the stability properties of large inhomogeneous cores, which is usually quantified with the so-called eigenvalue separation, ES=1/k{sub 1} - 1/k{sub 0} where k{sub 0} and k{sub 1}, are the fundamental and first higher order eigenvalues, respectively. Numerical codes used for ICMF calculations usually do not have the option of calculating the higher order eigenvalues and eigenfunctions. In idealised systems, these can be calculated with semi-analytical methods. In order to get insight into the characteristics of the higher order eigenmodes of the neutron flux and the adjoint, these were calculated in a reflected homogeneous system with two-group theory. The adjoint eigenmodes are necessary if an orthogonality property needs to be used, such as the separation of the modes from a flux shape which is a sum of several eigenmodes. At the same time, the so-called numerical noise simulator, developed at the Dept., was extended such that it became suitable for the calculation of the higher order eigenmodes, both direct and adjoint ones. This simulator can treat real inhomogeneous cores, with an input deck compatible with that of SIMULATE. The simulator was used to calculate the

  9. Monitoring

    Science.gov (United States)

    ... Heart Disease and Diabetes Blood Glucose Monitoring Insulin Injection Resources Mental Health and Diabetes Healthy Holiday Eating Lifestyle Resources Improve Medication Taking Spanish Language Resources AADE7 Self-Care Behaviors ...

  10. Adaptive-spectral method of monitoring and diagnostic observability of static stresses of elements of mechanical constructions

    Science.gov (United States)

    Sedov, A. V.; Kalinchuk, V. V.; Bocharova, O. V.

    2017-10-01

    The evaluation of static stresses and strength of units and components is a crucial task for increasing reliability in the operation of vehicles and equipment, to prevent emergencies, especially in structures made of metal and composite materials. At the stage of creation and commissioning of structures to control the quality of manufacturing of individual elements and components, diagnostic control methods are widely used. They are acoustic, ultrasonic, X-ray, radiation methods and others. The using of these methods to control the residual life and the degree of static stresses of units and parts during operation is fraught with great difficulties both in methodology and in instrumentation. In this paper, the authors propose an effective method of operative control of the degree of static stresses of units and parts of mechanical structures which are in working condition, based on recording the changing in the surface wave properties of a system consisting of a sensor and a controlled environment (unit, part). The proposed method of low-frequency diagnostics of static stresses presupposes adaptive-spectral decomposition analysis of a surface wave created by external action (impact).

  11. Vibroacoustic Modeling and Path Control of Air-Borne Axle Whine Noise

    Directory of Open Access Journals (Sweden)

    Dong Guo

    2014-08-01

    Full Text Available The axle whine noise will eventually affect the vehicle noise performance. In this study, a systematic modeling approach is developed to analyze the axle whine problem by considering the hypoid gear mesh from the tooth contact process as well as the system dynamics effect with gear design parameters and shaft-bearing-housing system taken into account. Moreover, the tuning of the dominant air-borne path is modeled analytically by using the sound transmission loss idea. First, gear tooth load distribution results are obtained in a 3-dimensional loaded tooth contact analysis program. Then mesh parameters are synthesized and applied to a linear multibody gear dynamic model to obtain dynamic mesh and bearing responses. The bearing responses are used as the excitation force to a housing finite element model. Finally, the vibroacoustic analysis of the axle is performed using the boundary element method; sound pressure responses in the axle surface are then simulated. Transmission losses of different panel partitions are included in the final stage to guide the tuning of air-borne paths to reduce the radiated axle whine noise. The proposed approach gives a more in-depth understanding of the axle whine generation and therefore can further facilitate the system design and trouble-shooting.

  12. Overview of the Orion Vibroacoustic Test Capability at NASA Glenn Research Center

    Science.gov (United States)

    Hughes, William O.; Hozman, Aron D.; McNelis, Mark E.; Otten, Kim D.

    2008-01-01

    In order to support the environmental test needs for our new Orion and Constellation program, NASA is developing unique world-class test facilities. To optimize this testing of spaceflight hardware while minimizing transportation issues, a one-stop, under one roof test capability is being developed at the Space Power Facility at the NASA Glenn Research Center's Plum Brook Station. This facility will provide the capability to perform the following environmental testing: (1) reverberation acoustic testing, (2) mechanical base-shake sine testing, (3) modal testing, (4) thermal-vacuum testing, and (5) EMI/EMC (electromagnetic interference and compatibility) testing. An overview of this test capability will be provided in this presentation, with special focus on the two new vibroacoustic test facilities currently being designed and built, the Reverberant Acoustic Test Facility (RATF) and the Mechanical Vibration Facility (MVF). Testing of the engineering developmental hardware and qualification hardware of the Orion (Crew Exploration Vehicle) will commence shortly after the facilities are commissioned.

  13. Vibroacoustic Optimization of Stiffening Ribs and Damping Material Distribution on Sheet Metal Parts

    Directory of Open Access Journals (Sweden)

    M. Carfagni

    2004-01-01

    Full Text Available Vehicle noise and vibration levels are basic parameters in passenger comfort. Both static and dynamic stiffness of sheet metal parts is commonly increased by means of stiffening ribs. Vibrations are also reduced by adding a layer of damping material on the floor, the roof, the firewall and other parts of the vehicle. In common practice the panels to be treated are ribbed according to criteria based on the designer’s experience, rather than on well defined design procedures and are uniformly covered by a layer of damping material. However, these are not efficient design solutions, especially with regard to the effectiveness of vibration reduction and to weight containment. In this paper a novel approach to achieve an optimal distribution of stiffening ribs and damping material will be presented. The proposed method is based on a Genetic Algorithm (G.A. procedure which takes into account both the vibroacoustic performance and the weight and cost reduction. A simple case study will be illustrated to demonstrate the capabilities of the developed procedure.

  14. Recovery of Biot's transition frequency of air-saturated poroelastic media using vibroacoustic spectroscopy

    Science.gov (United States)

    Ogam, Erick; Fellah, Z. E. A.

    2014-08-01

    The transition frequency marks the passage from low-frequency viscosity dominated flow to high-frequency inertia dominated one in porous media. It was one of the principal characteristics predicted by Biot's theory. The transition frequency has been a theoretical concept for which only theoretical expressions have been developed in recent years. A vibroacoustic spectroscopy experimental method to recover the characteristic frequency (fC) and for gaining insight into the frequency response of fluid-saturated porous materials has been developed. Long thin air-saturated porous rods solicited mechanically are employed for the experiment. Changes in the fluid flow profile with excitation frequency results in relative motion between the skeleton and the saturating-fluid. This enhances the frictional viscous forces, which, in turn, increases damping of the skeletal motion. These transitions are signaled by observable cues in the acquired laser-vibrometry spectrum of the rods' longitudinal vibration mode patterns. The resonance peaks exhibit sudden attenuation (increase in damping) and are interrupted at the transition frequencies evoking a change of propagation medium. These patterns are compared with those of two plains, single phase material (viscoelastic) rods whose modes stand out as regularly spaced moderately damped peaks.

  15. Responses to vibroacoustic stimulation in a fetus with an encephalocele compared to responses of normal fetuses.

    Science.gov (United States)

    van Heteren, C F; Boekkooi, P F; Jongsma, H W; Nijhuis, J G

    2000-01-01

    Observation of fetal movement and fetal heart rate (FHR) responses to repeated vibroacoustic stimulation (VAS) might be useful as a measure to assess fetal well-being and to assess the integrity of the fetal central nervous system (CNS). We observed the movement and FHR responses to repeated VAS of a term fetus with a serious brain anomaly as compared to responses of normal term fetuses. In 37 normal term fetuses and in a term fetus with an encephalocele we studied movement and FHR response to repeated VAS. All normal fetuses responded within 1 s after stimulation with general body movement and FHR acceleration. At 36 gestational weeks, no movement or FHR responses were seen in the fetus with an encephalocele. Repetition of the test in this fetus after one week still showed no response to repeated VAS. Normal fetuses showed movement and FHR responses to external stimulation. The fetus with an encephalocele did not respond to repeated VAS with a movement or FHR acceleration. Case studies in fetuses with structural anomalies of the CNS are needed to gain insight into the spectrum of possible responses to VAS.

  16. Analytical coupled vibroacoustic modeling of membrane-type acoustic metamaterials: Membrane model

    Science.gov (United States)

    Chen, Yangyang; Huang, Guoliang; Zhou, Xiaoming; Hu, Gengkai; Sun, Chin-Teh

    2014-09-01

    Membrane-type Acoustic Metamaterials (MAMs) have demonstrated unusual capacity in controlling low-frequency sound transmission/reflection. In this paper, an analytical vibroacoustic membrane model is developed to study sound transmission behavior of the MAM under a normal incidence. The MAM is composed of a prestretched elastic membrane with attached rigid masses. To accurately capture finite-dimension rigid mass effects on the membrane deformation, the point matching approach is adopted by applying a set of distributed point forces along the interfacial boundary between masses and the membrane. The accuracy and capability of the theoretical model is verified through the comparison with the finite element method. In particular, microstructure effects such as weight, size and eccentricity of the attached mass, pretension and thickness of the membrane on the resulting transmission peak and dip frequencies of the MAM are quantitatively investigated. New peak and dip frequencies are found for the MAM with one and multiple eccentric attached masses. The developed model can be served as an efficient tool for design of such membrane-type metamaterials.

  17. Analysis of vibroacoustic properties of dimpled beams using a boundary value model

    Science.gov (United States)

    Myers, Kyle R.

    Attention has been given recently to the use of dimples as a means of passively altering the vibroacoustic properties of structures. Because of their geometric complexity, previous studies have modeled dimpled structures using the finite element method. However, the dynamics of dimpled structures are not completely understood. The goal of this study is to provide a better understanding of these structures through the development of a boundary value model (BVM) using Hamilton's Variational Principle. The focus of this study is on dimpled beams, which represent the simplest form of a dimpled structure. A general model of a beam with N dimples in free vibration is developed. Since dimples formed via a stamping process do not change the mass of the beam, the dimple thickness is less than that of the straight segments. Differential equations of motion that describe the normal and axial motion of the dimpled beams are derived. Their numerical solution yields the natural frequencies and analytical mode shapes of a dimpled beam. The accuracy of this model is checked against those obtained using the finite element method, as well as the analytical studies on the vibrations of arches, and shown to be accurate. The effect of dimple placement, dimple angle, its chord length, its thickness, as well as beam boundary conditions on beam natural frequencies and mode shapes are investigated. For beams with axially restrictive boundary conditions, the results.

  18. Vibroacoustic Characterization of a New Hybrid Wing-Body Fuselage Concept

    Science.gov (United States)

    Allen, Albert R.; Przekop, Adam

    2012-01-01

    A lighter, more robust airframe design is required to withstand the loading inherent to next generation non cylindrical commercial airliners. The Pultruded Rod Stitched Efficient Unitized Structure concept, a highly integrated composite design involving a stitched and co-cured substructure, has been developed to meet such requirements. While this structure has been shown to meet the demanding out-of-plane loading requirements of the flat-sided pressurized cabin design, there are concerns that the stiff co-cured details will result in relatively high acoustic radiation efficiencies at frequencies well below the thin skin acoustic coincidence frequency. To address this concern and establish a set of baseline vibroacoustic characteristics, a representative test panel was fabricated and a suite of tests were conducted that involved measurements of panel vibration and radiated sound power during point force and diffuse acoustic field excitations. Experimental results are shown and compared with Finite Element and Statistical Energy Analysis model predictions through the use of modal and energy correlation techniques among others. The behavior of the structure subject to turbulent boundary layer excitation is also numerically examined.

  19. Vibroacoustic behavior of clamp mounted double-panel partition with enclosure air cavity.

    Science.gov (United States)

    Xin, F X; Lu, T J; Chen, C Q

    2008-12-01

    A theoretical study on the vibroacoustic performance of a rectangular double-panel partition clamp mounted in an infinite acoustic rigid baffle is presented. With the clamped boundary condition taken into account by the method of modal function, a double Fourier series solution to the dynamic response of the structure is obtained by employing the weighted residual method (i.e., the Galerkin method). The double series solution can be considered as the exact solution of the problem, as the structural and acoustic-structural coupling effects are fully accounted for and the solution converges numerically. The accuracy of the theoretical predictions is checked against existing experimental data, with good agreement achieved. The influence of several key parameters on the sound isolation capability of the double-panel configuration is then systematically studied, including panel dimensions, thickness of air cavity, elevation angle, and azimuth angle of incidence sound. The present method is suitable for double-panel systems of finite or infinite extent and is applicable for both low- and high-frequency ranges. With these merits, the proposed method compares favorably with a number of other approaches, e.g., finite element method, boundary element method, and statistical energy analysis method.

  20. Identification of material properties of orthotropic elastic cylinders immersed in fluid using vibroacoustic techniques.

    Science.gov (United States)

    Rosario, Daniel E; Brigham, John C; Aquino, Wilkins

    2008-11-01

    A numerical study is presented to show the potential for using vibroacoustic-based experiments to identify elastic material properties of orthotropic cylindrical vessels immersed in fluids. Sensitivity analyses and a simulated inverse problem are shown to quantify the potential for material characterization through the use of acoustic emissions. For comparison purposes, the analyses are also shown with the normal component of the velocity at the surface of the cylinder as the measured response in place of the acoustic pressure. The simulated experiment consisted of an orthotropic cylinder immersed in water with an impact force applied to the surface of the cylinder. The material parameters of the cylinder considered in the analyses were the circumferential and longitudinal elastic moduli, and the in-plane shear modulus. The velocity response is shown to provide sufficient information for characterizing all three moduli from a single experiment. Alternatively, the acoustic pressure response is shown to provide sufficient information for characterizing only the two elastic moduli from a single experiment. The analyses show that the acoustic pressure response does not have sufficient sensitivity to the in-plane shear modulus for characterization purposes.

  1. Increase in CD8+ and CD4+ T lymphocytes in patients with vibroacoustic disease.

    Science.gov (United States)

    Castro, A P; Aguas, A P; Grande, N R; Monteiro, E; Castelo Branco, N A

    1999-03-01

    Some workers employed by the aviation industry are exposed to large pressure amplitude and low frequency (LPALF) noise (> or =90 dB SPL, vibroacoustic disease (VAD), a whole-body noise-induced pathology. Since VAD patients have an increased prevalence of respiratory and skin infections, we investigated whether these individuals had any quantitative changes in the number of peripheral blood cell populations. Also, we investigated whether different types of noise environments are related to cell quantification. Quantification of peripheral blood cell populations was performed in venous blood samples of 34 VAD-diagnosed patients, and 41 controls. Leukocytes, monocytes, granulocytes, and surface phenotypes of CD8+ and CD4+ T lymphocytes were considered. We found that VAD patients showed a statistically significant elevation in the number of circulating CD8+ and CD4+ T lymphocytes when compared with the control population, but not when compared among different noise-environments. Monocyte and granulocyte populations did not register significant differences. VAD patients present enhancement in the number of circulating cytotoxic T lymphocytes (CD8+ and CD4+ T cells) thus indicating that this environmental disease is associated with quantitative changes in immune cells.

  2. Efficient modeling of flat and homogeneous acoustic treatments for vibroacoustic finite element analysis. Direct field formulations

    Science.gov (United States)

    Alimonti, L.; Atalla, N.

    2016-04-01

    This paper is concerned with the development of a simplified model for noise control treatments to speed up finite element analysis in vibroacoustic applications. The methodology relies on the assumption that the acoustic treatment is flat and homogeneous. Moreover, its finite lateral extent is neglected. This hypothesis is justified by short wavelength and large dissipation, which suggest that the reflected field emanating from the acoustic treatment lateral boundaries does not substantially affect its dynamic response. Under these circumstances, the response of the noise control treatment can be formally obtained by means of convolution integrals involving simple analytical kernels (i.e. Green functions). Such fundamental solutions can be computed efficiently by the transfer matrix method. However, some arbitrariness arises in the formulation of the mathematical model, resulting in different baffling conditions at the two ends of the treatment to be considered. Thus, the paper investigates the possibility of different formulations (i.e. baffling conditions) within the same hybrid finite element-transfer matrix framework, seeking for the best strategy in terms of tradeoff between efficiency and accuracy. Numerical examples are provided to show strengths and limitations of the proposed methodology.

  3. Vibroacoustics of the piano soundboard: Reduced models, mobility synthesis, and acoustical radiation regime

    CERN Document Server

    Boutillon, Xavier

    2013-01-01

    In string musical instruments, the sound is radiated by the soundboard, subject to the strings excitation. This vibration of this rather complex structure is described here with models which need only a small number of parameters. Predictions of the models are compared with results of experiments that have been presented in Ege et al. [Vibroacoustics of the piano soundboard: (Non)linearity and modal properties in the low- and mid- frequency ranges, Journal of Sound and Vibration 332 (5) (2013) 1288-1305]. The apparent modal density of the soundboard of an upright piano in playing condition, as seen from various points of the structure, exhibits two well-separated regimes, below and above a frequency flim that is determined by the wood characteristics and by the distance between ribs. Above flim, most modes appear to be localised, presumably due to the irregularity of the spacing and height of the ribs. The low-frequency regime is predicted by a model which consists of coupled sub-structures: the two ribbed ar...

  4. Analytical coupled vibroacoustic modeling of membrane-type acoustic metamaterials: membrane model.

    Science.gov (United States)

    Chen, Yangyang; Huang, Guoliang; Zhou, Xiaoming; Hu, Gengkai; Sun, Chin-Teh

    2014-09-01

    Membrane-type acoustic metamaterials (MAMs) have demonstrated unusual capacity in controlling low-frequency sound transmission/reflection. In this paper, an analytical vibroacoustic membrane model is developed to study sound transmission behavior of the MAM under a normal incidence. The MAM is composed of a prestretched elastic membrane with attached rigid masses. To accurately capture finite-dimension rigid mass effects on the membrane deformation, the point matching approach is adopted by applying a set of distributed point forces along the interfacial boundary between masses and the membrane. The accuracy and capability of the theoretical model is verified through the comparison with the finite element method. In particular, microstructure effects such as weight, size, and eccentricity of the attached mass, pretension, and thickness of the membrane on the resulting transmission peak and dip frequencies of the MAM are quantitatively investigated. New peak and dip frequencies are found for the MAM with one and multiple eccentric attached masses. The developed model can be served as an efficient tool for design of such membrane-type metamaterials.

  5. COMPLEX DIAGNOSTICS AND MONITORING OF PRIMARY GLAUCOMA SIMPLEX WITH USE OF COMPUTER COLORIMETRIC ANALYSIS AND DUPLEX DOPPLEROGRAPHY

    Directory of Open Access Journals (Sweden)

    I.O. Kolbenev

    2009-09-01

    Full Text Available Glaucoma simplex is one of the basic causes of blindness. The main problem of glaucoma is its early recognition. It's well known that changes of anatomic structure of each organ are preceded by functional disorders, including disturbances of hemodynamics. Method of computer colorimetric analysis of disk of optic nerve (DON was worked out for the purpose of objective evaluation of its chroma as one of hemodynamics detection criteria. Computer program for analysis of DON chroma with calculation of integrated index (color index was developed. DON chroma was analyzed in the group of persons suspected of glaucoma, in the group of patients with glaucoma simplex and in healthy people. This method along with confocal scanning tomography of DON allows to evaluate objectively in dynamics its state in the presence of glaucoma simplex. These methods are necessary to be used in complex for diagnostics of early stages of glaucoma simplex.

  6. Modeling of micro-perforated panels in a complex vibro-acoustic environment using patch transfer function approach

    OpenAIRE

    Maxit, Laurent; C. Yang; Cheng, Li; Guyader, Jean-Louis

    2012-01-01

    International audience; The micro-perforated panel (MPP) with a backing cavity is a well known efficient device for noise absorption. This device has been thoroughly studied in the experimental conditions of an acoustic tube (Kundt tube), in which the MPP is excited by a normal incident plane wave in one dimension. In an industrial situation, the efficiency of MPP may be influenced by the vibro-acoustic behaviour of the surrounding systems as well as excitation. To deal with this problem, a v...

  7. Assessment of a novel device-based diagnostic algorithm to monitor patient status in moderate-to-severe heart failure: rationale and design of the CLEPSYDRA study.

    Science.gov (United States)

    Auricchio, Angelo; Brugada, Josep; Ellenbogen, Kenneth A; Gold, Michael R; Leyva, Francisco

    2010-12-01

    Monitoring systems integrated into electronic implantable devices for heart failure (HF) have significantly expanded the possibility of obtaining diagnostic information and can be used to enhance patient follow-up. The ability to obtain advance warning of worsening HF is currently being explored using a variety of diagnostic parameters. A novel device-based algorithm, physiological diagnostic (PhD), combines data from minute ventilation and accelerometer sensors to provide an indicator of the overall status of HF patients and detect clinically relevant acute HF events. The objective of this study was to evaluate the effectiveness of the PhD algorithm for detecting HF events in patients with HF. CLEPSYDRA is a multicentre, prospective, non-randomized, single-arm double-blinded study in 62 centres in Europe, the USA, and Canada. Patients with moderate-to-severe HF, on stable optimal pharmacological therapy, QRS≥120 ms, and ejection fraction≤0.35% will be included. Patients will be followed at 3-month intervals until study end, or for a minimum of 13 months. The primary endpoint is the sensitivity of the PhD (proportion of HF-related clinical events occurring within a 4-week period after a PhD HF indication). Secondary endpoints include the sensitivity of PhD with regard to HF events related to oral treatment modification, and adverse events. The first patient was included in October 2009. At the time of manuscript submission (Week 26, 2010), 214 patients had been enrolled. Study results are expected in 2012. CLEPSYDRA will provide essential data on the utility of the PhD algorithm in a HF population with blinded investigators and patients. A successful outcome will demonstrate the potential for the algorithm to be implemented in clinical practice. This would improve clinical management and further the ability to generate dynamic and reliable risk profiles for patients with HF.

  8. Guideline for Monitoring and Management of Pediatric Patients Before, During, and After Sedation for Diagnostic and Therapeutic Procedures: Update 2016.

    Science.gov (United States)

    2016-10-01

    The safe sedation of children for procedures requires a systematic approach that includes the following: no administration of sedating medication without the safety net of medical/dental supervision, careful presedation evaluation for underlying medical or surgical conditions that would place the child at increased risk from sedating medications, appropriate fasting for elective procedures and a balance between the depth of sedation and risk for those who are unable to fast because of the urgent nature of the procedure, a focused airway examination for large (kissing) tonsils or anatomic airway abnormalities that might increase thepotential for airway obstruction, a clear understanding of the medication's pharmacokinetic and pharmacodynamic effects and drug interactions, appropriate training and skills in airway management to allow rescue of the patient, age- and size-appropriate equipment for airway management and venous access, appropriate medications and reversal agents, sufficient numbers of staff to both carry out the procedure and monitor the patient, appropriate physiologic monitoring during and after the procedure, a properly equipped and staffed recovery area, recovery to the presedation level of consciousness before discharge from medical/dental supervision, and appropriate discharge instructions. This report was developed through a collaborative effort of the American Academy of Pediatrics and the American Academy of Pediatric Dentistry to offer pediatric providers updated information and guidance in delivering safe sedation to children.

  9. The effects of Vibroacoustic treatment on girls and women with Rett Syndrome: Paper to the 2nd International Scientific Research Workshop: Infant Behaviour

    DEFF Research Database (Denmark)

    Wigram, Anthony Lewis

    2003-01-01

    Vibroacoustic therapy is a treatment using the relaxing effects of sedative music combined with pulsed, sinusoidal low frequency tones between 35Hz-70Hz, transmitted through bass speakers built into a bed or chair. This treatment has shown effects in reducing arousal level in girls and women with...... with Rett syndrome, and also reducing muscle tone....

  10. Guidelines for Monitoring and Management of Pediatric Patients Before, During, and After Sedation for Diagnostic and Therapeutic Procedures: Update 2016.

    Science.gov (United States)

    Coté, Charles J; Wilson, Stephen

    2016-07-01

    The safe sedation of children for procedures requires a systematic approach that includes the following: no administration of sedating medication without the safety net of medical/dental supervision, careful presedation evaluation for underlying medical or surgical conditions that would place the child at increased risk from sedating medications, appropriate fasting for elective procedures and a balance between the depth of sedation and risk for those who are unable to fast because of the urgent nature of the procedure, a focused airway examination for large (kissing) tonsils or anatomic airway abnormalities that might increase the potential for airway obstruction, a clear understanding of the medication's pharmacokinetic and pharmacodynamic effects and drug interactions, appropriate training and skills in airway management to allow rescue of the patient, age- and size-appropriate equipment for airway management and venous access, appropriate medications and reversal agents, sufficient numbers of staff to both carry out the procedure and monitor the patient, appropriate physiologic monitoring during and after the procedure, a properly equipped and staffed recovery area, recovery to the presedation level of consciousness before discharge from medical/dental supervision, and appropriate discharge instructions. This report was developed through a collaborative effort of the American Academy of Pediatrics and the American Academy of Pediatric Dentistry to offer pediatric providers updated information and guidance in delivering safe sedation to children. Copyright © 2016 American Academy of Pediatric Dentistry and American Academy of Pediatrics. This report is being published concurrently in Pediatric Dentistry July 2016. The articles are identical. Either citation can be used when citing this report.

  11. Computerised decision support systems in order communication for diagnostic, screening or monitoring test ordering: systematic reviews of the effects and cost-effectiveness of systems.

    Science.gov (United States)

    Main, C; Moxham, T; Wyatt, J C; Kay, J; Anderson, R; Stein, K

    2010-10-01

    Order communication systems (OCS) are computer applications used to enter diagnostic and therapeutic patient care orders and to view test results. Many potential benefits of OCS have been identified including improvements in clinician ordering patterns, optimisation of clinical time, and aiding communication processes between clinicians and different departments. Many OCS now include computerised decision support systems (CDSS), which are information systems designed to improve clinical decision-making. CDSS match individual patient characteristics to a computerised knowledge base, and software algorithms generate patient-specific recommendations. To investigate which CDSS in OCS are in use within the UK and the impact of CDSS in OCS for diagnostic, screening or monitoring test ordering compared to OCS without CDSS. To determine what features of CDSS are associated with clinician or patient acceptance of CDSS in OCS and what is known about the cost-effectiveness of CDSS in diagnostic, screening or monitoring test OCS compared to OCS without CDSS. A generic search to identify potentially relevant studies for inclusion was conducted using MEDLINE, EMBASE, Cochrane Controlled Trials Register (CCTR), CINAHL (Cumulative Index to Nursing and Allied Health Literature), DARE (Database of Abstracts of Reviews of Effects), Health Technology Assessment (HTA) database, IEEE (Institute of Electrical and Electronic Engineers) Xplore digital library, NHS Economic Evaluation Database (NHS EED) and EconLit, searched between 1974 and 2009 with a total of 22,109 titles and abstracts screened for inclusion. CDSS for diagnostic, screening and monitoring test ordering OCS in use in the UK were identified through contact with the 24 manufacturers/suppliers currently contracted by the National Project for Information Technology (NpfIT) to provide either national or specialist decision support. A generic search to identify potentially relevant studies for inclusion in the review was

  12. Compliance and quality control monitoring of diagnostic X-ray facilities in Dar es Salaam city, Tanzania

    Energy Technology Data Exchange (ETDEWEB)

    Nkuba, Leonid L.; Nyanda, Pendo B., E-mail: leonid.nkuba@taec.or.tz [Tanzania Atomic Energy Commission, Radiation Control Directorate, Dar es Salaam (Tanzania, United Republic of)

    2017-09-01

    The compliance evaluation and quality control measurements on 60 diagnostic X-ray units were performed. The results on legal compliance show that 25 % of X-ray facilities operated without or with an expired license. The rest of the centers were new and had already applied for license and others had valid licenses. For basic requirements compliance, 47 % of X-ray facilities did not have the changing cubicles, 37 % of X-ray facilities did not post radiation warning sign and symbols also 46 % of units were found either without protective gear or operated by unqualified personnel. The QC test results showed that 93 % had X-ray tube voltage within the tolerance limit of 10 % and HVL ≥ 2.3 mmAl, at 80 kV was observed in 98.2 % of the units, whereas 98 % of exposure had acceptable kV reproducibility within the tolerance limit of 5 %. Of the X-ray generators assessed, 93 % had tolerable mAs linearity. 93 % and 97 % had acceptable beam alignment and light beam diaphragm. Of the assessed units, 13 (93 %) had tube leakage < 1000 μGy/hr at 1m. For shielding tests, 47 % of units had radiation levels above 0.5 μSv/hr at the main door leading to the X-ray rooms and the registration area. The dose rates > 10 μSv/hr were recorded at viewing windows, walls and doors of control cubicles and behind the doors of changing cubicles. These dose rates indicating higher health risk to workers and member of public. (author)

  13. Comparison of Estimation Techniques for Vibro-Acoustic Transfer Path Analysis

    Directory of Open Access Journals (Sweden)

    Paulo Eduardo França Padilha

    2006-01-01

    Full Text Available Vibro-acoustic Transfer Path Analysis (TPA is a tool to evaluate the contribution of different energy propagation paths between a source and a receiver, linked to each other by a number of connections. TPA is typically used to quantify and rank the relative importance of these paths in a given frequency band, determining the most significant one to the receiver. Basically, two quantities have to be determined for TPA: the operational forces at each transfer path and the Frequency Response Functions (FRF of these paths. The FRF are obtained either experimentally or analytically, and the influence of the mechanical impedance of the source can be taken into account or not. The operational forces can be directly obtained from measurements using force transducers or indirectly estimated from auxiliary response measurements. Two methods to obtain the operational forces indirectly – the Complex Stiffness Method (CSM and the Matrix Inversion Method (MIM – associated with two possible configurations to determine the FRF – including and excluding the source impedance – are presented and discussed in this paper. The effect of weak and strong coupling among the paths is also commented considering the techniques previously presented. The main conclusion is that, with the source removed, CSM gives more accurate results. On the other hand, with the source present, MIM is preferable. In the latter case, CSM should be used only if there is a high impedance mismatch between the source and the receiver. Both methods are not affected by a higher or lower degree of coupling among the transfer paths.

  14. A three-dimensional vibroacoustic model for the prediction of underwater noise from offshore pile driving

    Science.gov (United States)

    Tsouvalas, A.; Metrikine, A. V.

    2014-04-01

    Steel monopiles are nowadays widely used as foundations for a large number of offshore structures. The installation procedure commonly involves a pile driving process which can last up to several hours depending upon pile dimensions, soil conditions and input energy of the hydraulic hammer. In impact pile driving, a hydraulic hammer delivers a series of hammer blows at the head of the pile that drive the pile into the sediment. Each hammer strike results in pile vibrations that emit strong impulsive sounds into the water column which can be harmful for the marine ecosystem. With today's increasing concern regarding the environmental impact of such operations, engineering tools which will be able to provide reliable predictions of the underwater noise levels are required. In this study, a linear semi-analytical formulation of the coupled vibroacoustics of a complete pile-water-soil interaction model is addressed. The pile is described by a high order thin shell theory whereas both water and soil are modelled as three-dimensional continua. Results obtained with the developed model indicate that the near-field response in the water column consists mainly of pressure conical waves generated by the supersonic compressional waves in the pile excited by the impact hammer. The soil response is dominated by shear waves with almost vertical polarization. The Scholte waves are also generated at the water-seabed interface which can produce pressure fluctuations in the water column that are particularly significant close to the sea floor. The effects of soil elasticity and pile size are thoroughly investigated and their influence on the generated pressure levels is highlighted. The results are also compared with those ones of a similar model in which the soil is treated as an equivalent acoustic fluid. It is shown that the latter approximation can yield inaccurate results at low frequencies especially for harder soil sediments.

  15. Fetal habituation to vibroacoustic stimulation in relation to fetal states and fetal heart rate parameters.

    Science.gov (United States)

    van Heteren, C F; Boekkooi, P F; Jongsma, H W; Nijhuis, J G

    2001-03-01

    Fetal habituation to repeated stimulation has the potential to become a tool in the assessment of fetal condition and of the function of the fetal central nervous system (CNS). However, the influence of fetal quiescence and activity on habituation remains to be clarified. We studied habituation and the influence of fetal state and fetal heart rate (FHR) parameters on habituation in healthy term fetuses. We studied habituation in 37 healthy fetuses in two tests with an interval of 10 min. The vibroacoustic stimuli were applied to the maternal abdomen above the fetal legs for a period of 1 s every 30 s. A fetal trunk movement within 1 s after stimulation was defined as a positive response. Habituation rate is defined as the number of stimuli applied before an observed non-response to four consecutive stimuli. The FHR patterns (FHRP) of the 10 min observation period before and after the tests were visually classified. Fetal states were defined according to the FHRP. Baseline FHR, FHR variability and the number of accelerations were calculated in a subgroup of 25 fetuses. Of the 32 fetuses that responded normally during the first test, 26 habituated and six had persistent responses. The median habituation rate decreased significantly in the second test (P=0.001). There was no difference in habituation rate between fetuses that where initially in a quiet state and those in an active state. The FHR parameters before the first test and the difference between these FHR parameters before and after the test did not correlate with the habituation rate. Although the majority of healthy fetuses was able to habituate, the interfetal variability in habituation performance is such that testing of habituation seems not to be a sensitive tool for the assessment of the fetal CNS. This variability is neither the result of differences in fetal state nor of the various FHR parameters before testing, nor of the difference in change of FHR parameters arising from stimulation.

  16. Calcium carbonate crystallizations on hypogean mural paintings: a pilot study of monitoring and diagnostics in Roman catacombs

    Science.gov (United States)

    Tapete, D.; Fratini, F.; Mazzei, B.; Camaiti, M.; Cantisani, E.; Riminesi, C.; Manganelli Del Fà, R.; Cuzman, O.; Tiano, P.

    2012-04-01

    One of the deterioration processes affecting mural paintings and rock surfaces within manmade hypogea consists in the formation of calcium carbonate crystallizations, which can create thick coverage and incrustations, even in some cases speleothems. These chemical reactions necessarily require the availability of calcium sources, which can be also of anthropogenic origin (e.g., lime-based mortars). Microclimate parameters also represent environmental forcing factors, on which the morphology and the degree of crystallinity of the precipitated carbonates depend. Understanding past/recent dynamics of carbonate precipitation implies a deep knowledge of the relationships between the exposed surfaces and the microclimate conditions, the impacts of external factors (e.g., groundwater infiltration and percolation from the overlying soil) and how they change over time. This is particularly fundamental for the preservation of hypogean sites which have not comparison with other typologies of environment due to their uniqueness, such as the ancient catacombs carved underneath the suburbs of Rome (Italy), since the 2nd century AD. In this paper we present the multidisciplinary methodological approach designed for the instrumental monitoring of the microphysical environment of the Catacombs of Saints Mark, Marcellian and Damasus, in the framework of the co-operation between the Institute for the Conservation and Valorization of Cultural Heritage and Pontifical Commission for Sacred Archaeology, Vatican, on the project HYPOGEA. Temperature inside the catacomb and on the surfaces, air relative humidity and CO2 concentration are the main of the parameters continuously measured by means of data loggers installed within the cubicles. Contemporarily, standardized methods of photographic documentation and digital micro-photogrammetry are used for change detection analysis of the painted surfaces and ancient plasters, as well as of the test areas purposely realized by applying fresh

  17. Rotorcraft Diagnostics Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Under this SBIR program, Ridgetop will introduce the first low-cost, low-power, and lightweight data monitoring solution for rotorcraft diagnostics. The solution is...

  18. Laser-induced incandescence (LII) diagnostic for in situ monitoring of nanoparticle synthesis in a high-pressure arc discharge

    Science.gov (United States)

    Yatom, Shurik; Vekselman, Vladislav; Mitrani, James; Stratton, Brentley; Raitses, Yevgeny; LaboratoryPlasma Nanosynthesis Team

    2016-10-01

    A DC arc discharge is commonly used for synthesis of carbon nanoparticles, including buckyballs, carbon nanotubes, and graphene flakes. In this work we show the first results of nanoparticles monitored during the arc discharge. The graphite electrode is vaporized by high current (60 A) in a buffer Helium gas leading to nanoparticle synthesis in a low temperature plasma. The arc was shown to oscillate, which can possibly influence the nano-synthesis. To visualize the nanoparticles in-situ we employ the LII technique. The nanoparticles with radii >50 nm, emerging from the arc area are heated with a short laser pulse and incandesce. The resulting radiation is captured with an ICCD camera, showing the location of the generated nanoparticles. The images of incandescence are studied together with temporally synchronized fast-framing imaging of C2 emission, to connect the dynamics of arc instabilities, C2 molecules concentration and nanoparticles. The time-resolved incandescence signal is analyzed with combination of ex-situ measurements of the synthesized nanoparticles and LII modeling, to provide the size distribution of produced nanoparticles. This work was supported by US Department of Energy, Office of Science, Basic Energy Sciences, Materials Sciences and Engineering Division.

  19. An alpha-synuclein MRM assay with diagnostic potential for Parkinson's disease and monitoring disease progression

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Li [Department of Pathology, University of Washington, Seattle WA USA; Stewart, Tessandra [Department of Pathology, University of Washington, Seattle WA USA; Shi, Min [Department of Pathology, University of Washington, Seattle WA USA; Pottiez, Gwenael [Department of Pathology, University of Washington, Seattle WA USA; Dator, Romel [Department of Pathology, University of Washington, Seattle WA USA; Wu, Rui [Department of Pathology, University of Washington, Seattle WA USA; Department of Pathology, No. 3 Hospital of Beijing University, Beijing China; Aro, Patrick [Department of Pathology, University of Washington, Seattle WA USA; Schuster, Robert J. [Department of Pathology, University of Washington, Seattle WA USA; Ginghina, Carmen [Department of Pathology, University of Washington, Seattle WA USA; Pan, Catherine [Department of Pathology, University of Washington, Seattle WA USA; Gao, Yuqian [Pacific Northwest National Laboratory, Richland WA USA; Qian, Weijun [Pacific Northwest National Laboratory, Richland WA USA; Zabetian, Cyrus P. [Parkinson' s Disease Research and Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle WA USA; Department of Neurology, University of Washington School of Medicine, Seattle WA USA; Hu, Shu-Ching [Department of Neurology, University of Washington School of Medicine, Seattle WA USA; Quinn, Joseph F. [Department of Neurology, Oregon Health and Science University, Portland OR USA; Zhang, Jing [Department of Pathology, University of Washington, Seattle WA USA; Department of Pathology, Peking University Health Science Centre and Third Hospital, Beijing 100083 China

    2017-04-19

    Aim: The alpha-synuclein (α-syn) level in human cerebrospinal fluid (CSF), as measured by immunoassays, is promising as a Parkinson’s disease (PD) biomarker. However, the levels of total α-syn are inconsistent among studies with large cohorts and different measurement platforms. Total α-syn level also does not correlate with disease severity or progression. Here, we developed a highly sensitive Multiple Reaction Monitoring (MRM) method to measure absolute CSF α-syn peptide concentrations without prior enrichment or fractionation, aiming to discover new candidate biomarkers. Results: Six peptides covering 73% of protein sequence were reliably identified, and two were consistently quantified in cross-sectional and longitudinal cohorts. Absolute concentration of α-syn in human CSF was determined to be 2.1ng/mL. A unique α-syn peptide, TVEGAGSIAAATGFVK (81-96), displayed excellent correlation with previous immunoassay results in two independent PD cohorts (p < 0.001), correlated with disease severity, and its changes significantly tracked the disease progression longitudinally. Conclusions: An MRM assay to quantify human CSF α-syn was developed and optimized. Sixty clinical samples from cross-sectional and longitudinal PD cohorts were analyzed with this approach. Although further larger-scale validation is needed, the results suggest that α-syn peptide could serve as a promising biomarker in PD diagnosis and progression.

  20. Gearbox vibration diagnostic analyzer

    Science.gov (United States)

    1992-01-01

    This report describes the Gearbox Vibration Diagnostic Analyzer installed in the NASA Lewis Research Center's 500 HP Helicopter Transmission Test Stand to monitor gearbox testing. The vibration of the gearbox is analyzed using diagnostic algorithms to calculate a parameter indicating damaged components.

  1. Serum IgE Levels: An Effective Diagnostic Tool for Evaluation and Monitoring of Orbital Fungal Granuloma.

    Science.gov (United States)

    Afghani, Tayyab; Mansoor, Hassan; Syed, Abdullah Naeem

    2015-09-01

    To determine the changes in IgE levels in diagnosis and postoperative monitoring of orbital fungal granuloma. Descriptive analytical study. Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan, from July 2012 to June 2013. Cases with clinically high index of suspicion for orbital fungal granuloma and 50 healthy volunteers were inducted as control subjects. Patients with recurrent cases of orbital fungal granuloma, previous orbital surgery, and those with very low clinical suspicion of fungal granuloma were excluded. Total serum IgE level (IU/ml), eosinophil counts and skin prick test were performed in all subjects. Independent t-test was used for comparison of healthy volunteers and patients with biopsy proven orbital fungal granuloma. Repeated measures ANOVA was used for comparing the preoperative and postoperative total serum IgE level of patients with biopsy proven fungal granuloma. The mean total serum IgE level for the healthy volunteers was 208.82 ±41.43 IU/ml. The mean pre-operative IgE value of histologically confirmed cases of fungal granuloma was 1613.72 ±282.83 IU/ml. The total serum IgE level gradually declined after surgery and anti-fungal treatment. The mean serum IgE level 3, 6 and 9 months postoperatively were 1039.48 ±308.40, 568.77 ±162.01 and 224.92 ±51.55 IU/ml respectively. These tests showed that the drop in IgE level in cases of fungal granuloma with treatment was statistically significant (p granuloma.

  2. Monitoring and Analysis of In-Pile Phenomena in Advanced Test Reactor using Acoustic Telemetry

    Energy Technology Data Exchange (ETDEWEB)

    Agarwal, Vivek [Idaho National Lab. (INL), Idaho Falls, ID (United States). Dept. of Human Factors, Controls, and Statistics; Smith, James A. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Dept. of Fuel Performance and Design; Jewell, James Keith [Idaho National Lab. (INL), Idaho Falls, ID (United States). Dept. of Fuel Performance and Design

    2015-02-01

    The interior of a nuclear reactor presents a particularly harsh and challenging environment for both sensors and telemetry due to high temperatures and high fluxes of energetic and ionizing particles among the radioactive decay products. A number of research programs are developing acoustic-based sensing approach to take advantage of the acoustic transmission properties of reactor cores. Idaho National Laboratory has installed vibroacoustic receivers on and around the Advanced Test Reactor (ATR) containment vessel to take advantage of acoustically telemetered sensors such as thermoacoustic (TAC) transducers. The installation represents the first step in developing an acoustic telemetry infrastructure. This paper presents the theory of TAC, application of installed vibroacoustic receivers in monitoring the in-pile phenomena inside the ATR, and preliminary data processing results.

  3. Multi-GPU and multi-CPU accelerated FDTD scheme for vibroacoustic applications

    Science.gov (United States)

    Francés, J.; Otero, B.; Bleda, S.; Gallego, S.; Neipp, C.; Márquez, A.; Beléndez, A.

    2015-06-01

    The Finite-Difference Time-Domain (FDTD) method is applied to the analysis of vibroacoustic problems and to study the propagation of longitudinal and transversal waves in a stratified media. The potential of the scheme and the relevance of each acceleration strategy for massively computations in FDTD are demonstrated in this work. In this paper, we propose two new specific implementations of the bi-dimensional scheme of the FDTD method using multi-CPU and multi-GPU, respectively. In the first implementation, an open source message passing interface (OMPI) has been included in order to massively exploit the resources of a biprocessor station with two Intel Xeon processors. Moreover, regarding CPU code version, the streaming SIMD extensions (SSE) and also the advanced vectorial extensions (AVX) have been included with shared memory approaches that take advantage of the multi-core platforms. On the other hand, the second implementation called the multi-GPU code version is based on Peer-to-Peer communications available in CUDA on two GPUs (NVIDIA GTX 670). Subsequently, this paper presents an accurate analysis of the influence of the different code versions including shared memory approaches, vector instructions and multi-processors (both CPU and GPU) and compares them in order to delimit the degree of improvement of using distributed solutions based on multi-CPU and multi-GPU. The performance of both approaches was analysed and it has been demonstrated that the addition of shared memory schemes to CPU computing improves substantially the performance of vector instructions enlarging the simulation sizes that use efficiently the cache memory of CPUs. In this case GPU computing is slightly twice times faster than the fine tuned CPU version in both cases one and two nodes. However, for massively computations explicit vector instructions do not worth it since the memory bandwidth is the limiting factor and the performance tends to be the same than the sequential version

  4. Vibroacoustics of the piano soundboard: Reduced models, mobility synthesis, and acoustical radiation regime

    Science.gov (United States)

    Boutillon, Xavier; Ege, Kerem

    2013-09-01

    In string musical instruments, the sound is radiated by the soundboard, subject to the strings excitation. This vibration of this rather complex structure is described here with models which need only a small number of parameters. Predictions of the models are compared with the results of experiments that have been presented in Ege et al. [Vibroacoustics of the piano soundboard: (non)linearity and modal properties in the low- and mid-frequency ranges, Journal of Sound and Vibration 332 (5) (2013) 1288-1305]. The apparent modal density of the soundboard of an upright piano in playing condition, as seen from various points of the structure, exhibits two well-separated regimes, below and above a frequency flim that is determined by the wood characteristics and by the distance between ribs. Above flim, most modes appear to be localised, presumably due to the irregularity of the spacing and height of the ribs. The low-frequency regime is predicted by a model which consists of coupled sub-structures: the two ribbed areas split by the main bridge and, in most cases, one or two so-called cut-off corners. In order to assess the dynamical properties of each of the subplates (considered here as homogeneous plates), we propose a derivation of the (low-frequency) modal density of an orthotropic homogeneous plate which accounts for the boundary conditions on an arbitrary geometry. Above flim, the soundboard, as seen from a given excitation point, is modelled as a set of three structural wave-guides, namely the three inter-rib spacings surrounding the excitation point. Based on these low- and high-frequency models, computations of the point-mobility and of the apparent modal densities seen at several excitation points match published measurements. The dispersion curve of the wave-guide model displays an acoustical radiation scheme which differs significantly from that of a thin homogeneous plate. It appears that piano dimensioning is such that the subsonic regime of acoustical

  5. Assessment of usefulness of amplitude-spectrum discriminants for vibroacoustic diagnosis of gearheads of shearer loaders with ranging arms

    Energy Technology Data Exchange (ETDEWEB)

    Sikora, W.; Zakrzewski, T.

    1985-01-01

    Use of vibration and acoustic measurement is analyzed for detection of failures and wear assessment of gearheads of the KWB-3RDU shearer loaders with shearer drums on ranging arms. Problems associated with selecting the optimum measuring points on the gearheads as well as measuring methods and methods for statistical analysis of measurement results are analyzed. Amplitude and frequency range of vibrations generated by the elements of mechanical transmissions in the gearheads are investigated. Use of amplitude-spectrum discriminants for analyzing vibroacoustic processes during idle running and shearer drum operation under conditions of nominal loading is evaluated. Analyses showed that vibration and acoustic measurements are an efficienct method for wear assessment and forecasting service life of gearheads of the KWB-3RDU shearer loaders. The gearheads with the maximum vibrations were characterized by the lowest service life and the highest failure probability. Loading increase caused vibration increase under conditions of idle running and nominal loading. 13 references.

  6. Delta-He, Ret-He and a New Diagnostic Plot for Differential Diagnosis and Therapy Monitoring of Patients Suffering from Various Disease-Specific Types of Anemia.

    Science.gov (United States)

    Weimann, Andreas; Cremer, Malte; Hernáiz-Driever, Pablo; Zimmermann, Mathias

    2016-01-01

    The present study was aimed to prove the usefulness of a new diagnostic plot (Hema-Plot), illustrating the relationship between the hemoglobin content of reticulocytes (Ret-He) as a marker of functional iron deficiency and the difference between the reticulocyte and erythrocyte hemoglobin content (Delta-He) as a marker of an impaired hemoglobinization of newly formed reticulocytes occurring during inflammatory processes, to differentiate between various disease-specific types of anemia. A complete blood and reticulocyte count was performed on routine EDTA blood samples from 345 patients with and without various disease-specific types of anemia using the Sysmex XN-9000 hematology analyzer: blood healthy newborns (n = 23), blood healthy adults (n = 31), patients suffering from anemia of chronic disease (ACD) due to diverse oncological, chronic inflammatory, or autoimmune diseases (total n = 138) with (n = 65) and without therapy (n = 73), patients with thalassemia and/or hemoglobinopathy (n = 18), patients with iron deficiency anemia (IDA) (n = 35), patients with a combination of ACD and IDA (n = 17), as well as patients suffering from sepsis (total n = 83) with (n = 32) and without therapy (n = 51). The results for Ret-He, Delta-He, and C-reactive protein (CRP) were statistically compared (Mann-Whitney U Test) between the particular patient groups and the diagnostic plots were drawn. Delta-Hemoglobin showed a statistically significant difference between blood healthy newborns and blood healthy adults (p ≤ 0.05), while Ret-He and C-reactive protein did not. In addition, of all three biomarkers only Delta-He showed a statistically significant difference (p ≤ 0.05) between the ACD/IDA and IDA cohort. Delta-He, Ret-He, and CRP showed a statistically significant difference between patient cohorts with and without therapy suffering from ACD, ACD/IDA, and sepsis before and after medical therapy (p ≤ 0.05). The Hema-Plot illustrated the dynamic character of Ret-He and

  7. Vibro-Acoustic Analysis of Computer Disk Drive Components with Emphasis on Electro-Mechanical Noise Sources.

    Science.gov (United States)

    Lee, Ming-Ran

    Vibro-acoustic characteristics of compact electro -mechanical devices are not well understood. This study examines fundamental research issues in this area through the example case of a 3.5" personal computer hard disk drive. In particular, a narrow band mathematical model of the drive has been developed to predict prominent pure tones over the high frequency range (1-6.5 KHz). Through detailed analytical studies, it has been found that the motor torque pulsation of the brushless d.c. motor is the source for this noise problem. Accordingly, a simplified disk drive model consisting of motor driving a single disk is used to investigate key components, with emphasis on the development of new mathematical models to describe the source, path and radiator characteristics. Two different mathematical models have been developed for brushless d.c. motor to predict the torque spectrum associated with invertor switching logic, pulse width modulation control scheme, eccentricity, and magnetic saturation. Frequency contents of predicted variables are identified and matched with measured sound data. Additionally, the Galerkin's method (or modified harmonic balance) is also employed successfully to develop an efficient computational scheme which predicts the Fourier coefficients of torque pulsations directly including various effects associated with inductance harmonics and the fluctuation of rotor angular velocity. For the radiator (annular disk), modal base formulations of sound radiation have been developed by approximating disk eigen-functions. Specifically, the effects of modal coupling and source rotation on radiated sound are investigated. Analytical predictions match well with numerical results obtained by using a boundary element program. New mobility transfer functions (path) are derived to couple the source and radiator formulations in order to construct an overall vibro-acoustic model. Potential areas of further research including experimental validation are discussed.

  8. Development of an integrated condition monitoring and diagnostic system for motor-operated valves used in nuclear power plant; Desenvolvimento de sistema de monitoracao e diagnostico aplicado a valvulas moto-operadas utilizadas em centrais nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Carneiro, Alvaro Luiz Guimaraes

    2003-07-01

    The reliability question of the components, specifically of motor operated valves, became one of the most important issues to be investigated in nuclear power plants, considering security and life plant extension. Therefore, the necessity of improvements in monitoring and diagnosis methods started to be of extreme relevance in the maintenance predictive field, establishing as main goal the reliability and readiness of the system components. Specially in nuclear power plants, the predictive maintenance contributes in the security factor in order to diagnosis in advance the occurrence of a possible failure, preventing severe situations. It also presents a contribution on the economic side by establishing a better maintenance programming, and reducing unexpected shutdown. The development of non intrusive monitoring and diagnostic method makes it possible to identify malfunctions in plant components during normal plant operation. This dissertation presents the development of an integrated condition monitoring system for motor-operated valves used in nuclear power plants. The methodology used in this project is based on the electric motor power signatures analysis, during the closing and opening stroke time of the valve. Once the measurements baseline diagnostic of the motor-operated valve is taken, it is possible to detect long-term deviations during valve lifetime, detecting in advance valve failures. The system implements two parallel techniques for detection and categorization of anomalies: expert system using fuzzy logic based on rules and knowledge base, providing a systematic approach for decision making, and the Wavelet Transform Technique, where the main goal is to obtain more detailed information contained in the measured data, identifying and characterizing the transients phenomena in the time and frequency domains, correlating them to failures situations in the incipient stage. The conditioning monitoring and diagnostic system was designed and implemented at

  9. Evaluation of a multi-component approach to cognitive-behavioral therapy (CBT) using guided visualizations, cranial electrotherapy stimulation, and vibroacoustic sound.

    Science.gov (United States)

    Rogers, Donna R B; Ei, Sue; Rogers, Kim R; Cross, Chad L

    2007-05-01

    This pilot study examines the use of guided visualizations that incorporate both cognitive and behavioral techniques with vibroacoustic therapy and cranial electrotherapy stimulation to form a multi-component therapeutic approach. This multi-component approach to cognitive-behavioral therapy (CBT) was used to treat patients presenting with a range of symptoms including anxiety, depression, and relationship difficulties. Clients completed a pre- and post-session symptom severity scale and CBT skills practice survey. The program consisted of 16 guided visualizations incorporating CBT techniques that were accompanied by vibroacoustic therapy and cranial electrotherapy stimulation. Significant reduction in symptom severity was observed in pre- and post-session scores for anxiety symptoms, relationship difficulties, and depressive symptoms. The majority of the clients (88%) reported use of CBT techniques learned in the guided visualizations at least once per week outside of the sessions.

  10. A strategy for damage detection on large bearing constructions based on vibroacoustic signals. Ein Strategie zur Schadenserkennung an grossen Tragkonstruktionen auf vibroakustischer Signalbasis

    Energy Technology Data Exchange (ETDEWEB)

    Weber, A. (Akademie der Wissenschaften, Chemnitz (Germany))

    1991-01-01

    In the field of technical diagnosis analysis methods based on vibroacoustic signals are often used. Also modal system parameters can be used for the assessment of the bearing capacity of constructions. At present different institutes carry out research work in this area. Here the different approaches for the experimental determination of actual system parameters differ in the measuring technique as well as in the excitation mechanism used. The article gives a survey of the latest findings. (BWI).

  11. The relationship between the response to external light stimulation and behavioral states in the human fetus: how it differs from vibroacoustic stimulation.

    Science.gov (United States)

    Kiuchi, M; Nagata, N; Ikeno, S; Terakawa, N

    2000-05-01

    To determine the effects of external light stimulation on fetal behavioral states and know the difference from those of vibroacoustic stimulation. A flashlight and a vibroacoustic stimulator was applied directly on the maternal abdomen to determine the response of 56 normal fetuses at 36-40 weeks gestation. Fetal heart rate (FHR) and body movements were recorded using an actocardiograph, and fetal eye movements were observed using real-time ultrasonography. Using Nijhuis's criteria, the fetal behavioral states (1F-4F) were determined. FHR acceleration was considered a fetal response to the stimulations. The lag time between stimulation and fetal response was within 4 s. A positive response rate to the light stimulation was higher at behavioral states 2F (82%) and 3F (83%) than at state 1F (4%). Light stimulation changed the behavioral state of two of the six 3F fetuses (33%) from 3F to 4F. No change of state was observed in fetuses that were in states 1F and 2F. For vibroacoustic stimulation, fetal response was 100% positive and changes of states were observed frequently irrespective of the behavioral state before the stimulation. Fetal response to light stimulation is closely connected to fetal behavioral states and may reflect some distinct stages of the sleep-wakefulness cycle.

  12. A combined QC methodology in Ebro Delta HF radar system: real time web monitoring of diagnostic parameters and offline validation of current data

    Science.gov (United States)

    Lorente, Pablo; Piedracoba, Silvia; Soto-Navarro, Javier; Ruiz, Maria Isabel; Alvarez Fanjul, Enrique

    2015-04-01

    Over recent years, special attention has been focused on the development of protocols for near real-time quality control (QC) of HF radar derived current measurements. However, no agreement has been worldwide achieved to date to establish a standardized QC methodology, although a number of valuable international initiatives have been launched. In this context, Puertos del Estado (PdE) aims to implement a fully operational HF radar network with four different Codar SeaSonde HF radar systems by means of: - The development of a best-practices robust protocol for data processing and QC procedures to routinely monitor sites performance under a wide variety of ocean conditions. - The execution of validation works with in-situ observations to assess the accuracy of HF radar-derived current measurements. The main goal of the present work is to show this combined methodology for the specific case of Ebro HF radar (although easily expandable to the rest of PdE radar systems), deployed to manage Ebro River deltaic area and promote the conservation of an important aquatic ecosystem exposed to a severe erosion and reshape. To this aim, a web interface has been developed to efficiently monitor in real time the evolution of several diagnostic parameters provided by the manufacturer (CODAR) and used as indicators of HF radar system health. This web, updated automatically every hour, examines sites performance on different time basis in terms of: - Hardware parameters: power and temperature. - Radial parameters, among others: Signal-to-Noise Ratio (SNR), number of radial vectors provided by time step, maximum radial range and bearing. - Total uncertainty metrics provided by CODAR: zonal and meridional standard deviations and covariance between both components. - Additionally, a widget embedded in the web interface executes queries against PdE database, providing the chance to compare current time series observed by Tarragona buoy (located within Ebro HF radar spatial domain) and

  13. The concept and the principle of the diagnostic observability of the object in problems of monitoring and non-destructive testing

    Science.gov (United States)

    Sedov, A. V.

    2017-02-01

    The design of non-destructive testing systems relates to the solution of the problem of analysis of observability. It is the assessment of the opportunities of the set of measured parameters to diagnose the object, to identify emerging defects and the specific modes of operation. The term ‘observability’ in control theory does not correspond to the tasks of diagnosis and requires the model of the object’s state. The proposed concept of ‘diagnostic observability’ allows to use this term in tasks which aren’t related to the control. It doesn’t require the model of the object’s state, and realizes the estimation on the array of measurements performed for various diagnosed states of the object. The set of diagnostic state variables is determined as coordinates of diagnostic orthogonal space. The proposed principle of diagnostic observability is determined by the method of construction of the space of the diagnostics and by the analysis of the images of states of object. It can become a new basis for building an effective universal adaptive systems of non-destructive testing of complex technical and other objects.

  14. Experimental characterization of a bi-dimensional array of negative capacitance piezo-patches for vibroacoustic control

    Science.gov (United States)

    Tateo, F.; Collet, M.; Ouisse, M.; Ichchou, M. N.; Cunefare, K. A.

    2013-04-01

    A recent technological revolution in the fields of integrated MEMS has finally rendered possible the mechanical integration of active smart materials, electronics and power supply systems for the next generation of smart composite structures. Using a bi-dimensional array of electromechanical transducers, composed by piezo-patches connected to a synthetic negative capacitance, it is possible to modify the dynamics of the underlying structure. In this study, we present an application of the Floquet-Bloch theorem for vibroacoustic power flow optimization, by means of distributed shunted piezoelectric material. In the context of periodically distributed damped 2D mechanical systems, this numerical approach allows one to compute the multi-modal waves dispersion curves into the entire first Brillouin zone. This approach also permits optimization of the piezoelectric shunting electrical impedance, which controls energy diffusion into the proposed semi-active distributed set of cells. Furthermore, we present experimental evidence that proves the effectiveness of the proposed control method. The experiment requires a rectangular metallic plate equipped with seventy-five piezo-patches, controlled independently by electronic circuits. More specifically, the out-of-plane displacements and the averaged kinetic energy of the controlled plate are compared in two different cases (open-circuit and controlled circuit). The resulting data clearly show how this proposed technique is able to damp and selectively reflect the incident waves.

  15. Automation of vibroacoustic data bank for random vibration criteria development. [for the space shuttle and launch vehicles

    Science.gov (United States)

    Ferebee, R. C.

    1982-01-01

    A computerized data bank system was developed for utilization of large amounts of vibration and acoustic data to formulate component random vibration design and test criteria. This system consists of a computer, graphics tablet, and a dry-silver hard copier which are all desk-top type hardware and occupy minimal space. The data bank contains data from the Saturn V and Titan III flight and static test programs. The vibration and acoustic data are stored in the form of power spectral density and one-third octave band plots over the frequency range from 20 to 2000 Hz. The data was stored by digitizing each spectral plot by tracing with the graphics tablet. The digitized data was statistically analyzed and the resulting 97.5% probability levels were stored on tape along with the appropriate structural parameters. Standard extrapolation procedures were programmed for prediction of component random vibration test criteria for new launch vehicle and payload configurations. This automated vibroacoustic data bank system greatly enhances the speed and accuracy of formulating vibration test criteria. In the future, the data bank will be expanded to include all data acquired from the space shuttle flight test program.

  16. Analysis of Vibroacoustic Modulations for Crack Detection: A Time-Frequency Approach Based on Zhao-Atlas-Marks Distribution

    Directory of Open Access Journals (Sweden)

    A. Trochidis

    2014-01-01

    Full Text Available The vibro-acoustic modulation (VAM technique is probably the most widely used nonlinear method for crack detection. The VAM method is based on the effect of modulation of high-frequency acoustic waves by a low-frequency vibration. The intensity of the modulation is related to the severity of the damage and has been used so far as a damage index. The damage index simply based on the amplitude of the first side bands in the spectral domain often leads to controversial results about the severity of the damage. In this work, the nonlinear characteristics of the vibro-modulation were systematically investigated by employing time-frequency analysis based on the Zhao-Atlas-Marks (ZAM distribution. The results of the analysis show that the amplitude of the sideband components is modulated by the low frequency vibration and the modulation amplitude depends on the size of the crack. Based on the obtained results, a new damage index was defined in relation to the strength of the modulation. The new damage index is more sensitive and robust and correlates better with crack size compared to the index based on the amplitude of the sidebands.

  17. A hybrid approach for predicting the distribution of vibro-acoustic energy in complex built-up structures.

    Science.gov (United States)

    Maksimov, Dmitrii N; Tanner, Gregor

    2011-09-01

    Finding the distribution of vibro-acoustic energy in complex built-up structures in the mid-to-high frequency regime is a difficult task. In particular, structures with large variation of local wavelengths and/or characteristic scales pose a challenge referred to as the mid-frequency problem. Standard numerical methods such as the finite element method (FEM) scale with the local wavelength and quickly become too large even for modern computer architectures. High frequency techniques, such as statistical energy analysis (SEA), often miss important information such as dominant resonance behavior due to stiff or small scale parts of the structure. Hybrid methods circumvent this problem by coupling FEM/BEM and SEA models in a given built-up structure. In the approach adopted here, the whole system is split into a number of subsystems that are treated by either FEM or SEA depending on the local wavelength. Subsystems with relative long wavelengths are modeled using FEM. Making a diffuse field assumption for the wave fields in the short wave length components, the coupling between subsystems can be reduced to a weighted random field correlation function. The approach presented results in an SEA-like set of linear equations that can be solved for the mean energies in the short wavelength subsystems. © 2011 Acoustical Society of America

  18. Development of Fetal Movement between 26 and 36 Weeks’ Gestation in Response to Vibro-acoustic Stimulation

    Directory of Open Access Journals (Sweden)

    Marybeth eGrant-Beuttler

    2011-12-01

    Full Text Available Background: Ultrasound observation of fetal movement has documented general trends in motor development and fetal age when motor response to stimulation is observed. Evaluation of fetal movement quality, in addition to specific motor activity, may improve documentation of motor development and highlight specific motor responses to stimulation. Aims: The aim of this investigation was to assess fetal movement at 26 and 36 weeks gestation during three conditions (baseline, immediate response to vibro-acoustic stimulation (VAS, and post-response. Design: A prospective, longitudinal design was utilized. Subjects: Twelve normally developing fetuses, 8 females and 4 males, were examined with continuous ultrasound imaging. Outcome measures: The Fetal Neurobehavioral Coding System (FENS was used to evaluate the quality of motor activity during 10-second epochs over the three conditions. Results: Seventy-five percent of the fetuses at the 26 week assessment and 100% of the fetuses at the 36 week assessment responded with movement immediately following stimulation. Significant differences in head, fetal breathing, general, limb, and mouthing movements were detected between the 26 week and 36 week assessments. Movement differences between conditions were detected in head, fetal breathing, limb, and mouthing movements. Conclusions: Smoother and more complex movement was observed with fetal maturation. Following VAS stimulation, an immediate increase of large, jerky movements suggest instability in fetal capabilities. Fetal movement quality changes over gestation may reflect sensorimotor synaptogenesis in the central nervous system, while observation of immature movement patterns following VAS stimulation may reflect movement pattern instability.

  19. Experimental investigation of the influence of internal frames on the vibroacoustic behavior of a stiffened cylindrical shell using wavenumber analysis

    Science.gov (United States)

    Meyer, V.; Maxit, L.; Renou, Y.; Audoly, C.

    2017-09-01

    The understanding of the influence of non-axisymmetric internal frames on the vibroacoustic behavior of a stiffened cylindrical shell is of high interest for the naval or aeronautic industries. Several numerical studies have shown that the non-axisymmetric internal frame can increase the radiation efficiency significantly in the case of a mechanical point force. However, less attention has been paid to the experimental verification of this statement. That is why this paper proposes to compare the radiation efficiency estimated experimentally for a stiffened cylindrical shell with and without internal frames. The experimental process is based on scanning laser vibrometer measurements of the vibrations on the surface of the shell. A transform of the vibratory field in the wavenumber domain is then performed. It allows estimating the far-field radiated pressure with the stationary phase theorem. An increase of the radiation efficiency is observed in the low frequencies. Analysis of the velocity field in the physical and wavenumber spaces allows highlighting the coupling of the circumferential orders at the origin of the increase in the radiation efficiency.

  20. On a way to save memory when solving time domain boundary integral equations for acoustic and vibroacoustic applications

    Science.gov (United States)

    Thirard, Christophe; Parot, Jean-Marc

    2017-11-01

    Solving acoustic equations in the time domain, possibly coupled with the description of flexible structure dynamics, remains attractive as compared to solving the same in the frequency domain: this allows for better consideration of local non-linearities (acoustics/structure), and the boundary integral formulation (also known as BEM) offers an exact description of the infinite acoustic field based on a simple surface mesh (no need for 3D-volume discretization). Some issues remain however: the required memory space and computation time continue to grow rapidly when the number of elements of the surface mesh increases. In the case of a structure with a regular non-slender shape, the computational cost, measured in terms of required memory space, varies by Helmholtz number to the power of 4. This paper illustrates how the accelerating method called NGTD helps overcome this difficulty. This paper shows the applicability of 2 level NGTD to acoustic and vibroacoustic problems described solely by the hypersingular formulation for surfaces. It goes into more detail on some important aspects of the interpolation process and on the memory saving obtained. Implementation within the MOT (;March-On-Time;) ASTRYD code shows the benefits of this method. The memory requirement shows an estimated trend lower than power 1.35 of the number of surface elements.

  1. Plasma-derived parasitic microRNAs have insufficient concentrations to be used as diagnostic biomarker for detection of Onchocerca volvulus infection or treatment monitoring using LNA-based RT-qPCR.

    Science.gov (United States)

    Lagatie, Ole; Batsa Debrah, Linda; Debrah, Alex; Stuyver, Lieven J

    2017-03-01

    River blindness, caused by infection with the filarial nematode Onchocerca volvulus, is a neglected tropical disease affecting millions of people. There is a clear need for diagnostic tools capable of identifying infected patients, but that can also be used for monitoring disease progression and treatment efficacy. Plasma-derived parasitic microRNAs have been suggested as potential candidates for such diagnostic tools. We have investigated whether these parasitic microRNAs are present in sufficient quantity in plasma of Onchocerca-infected patients to be used as a diagnostic biomarker for detection of O. volvulus infection or treatment monitoring. Plasma samples were collected from different sources (23 nodule-positive individuals and 20 microfilaridermic individuals), microRNAs (miRNAs) were extracted using Qiagen miRNeasy kit, and a set of 17 parasitic miRNAs was evaluated on these miRNA extracts using miRCURY Locked Nucleic Acid (LNA) Universal RT microRNA PCR system. Of the 17 miRNAs evaluated, only 7 miRNAs were found to show detectable signal in a number of samples: bma-miR-236-1, bma-miR-71, ov-miR71-22nt, ov-miR-71-23nt, ov-miR-100d, ov-bantam-a, and ov-miR-87-3p. Subsequent melting curve analysis, however, indicated that the signals observed for ov-miR-71 variants and ov-miR-87-3p are non-specific. The other miRNAs only showed positive signal in one or few samples with Cq values just below the cutoff. Our data indicate that parasitic miRNAs are not present in circulation at a sufficiently high level to be used as biomarker for O. volvulus infection or treatment monitoring using LNA-based RT-qPCR analysis.

  2. Blood Glucose Monitoring Devices

    Science.gov (United States)

    ... In Vitro Diagnostics Blood Glucose Monitoring Devices Blood Glucose Monitoring Devices Share Tweet Linkedin Pin it More ... care settings to measure the amount of sugar (glucose) in your blood. What is glucose? Glucose is ...

  3. Vibroacoustic sound therapy: case studies with children with profound and multiple learning difficulties and the elderly in long-term residential care.

    Science.gov (United States)

    Ellis, Phil

    2004-01-01

    This paper describes the development of Vibroacoustic Sound Therapy, an approach which is being developed for use in special schools for children with profound and multiple learning difficulties, and in long-term care homes for the elderly and the elderly mentally infirm. Using non-invasive techniques and music/sound technology, children and the elderly are being empowered and enabled to (re)discover self expression and communication skills. Two case studies drawn from the world of the young disabled, and from the elderly, illustrate the potential for improving quality of life and well-being in these institutional settings.

  4. A comparison of the suitability of cathode ray tube (CRT) and liquid crystal display (LCD) monitors as visual stimulators in mfERG diagnostics.

    Science.gov (United States)

    Kaltwasser, Christoph; Horn, Folkert K; Kremers, Jan; Juenemann, Anselm

    2009-06-01

    The aim of this study was to determine up to which extent the specific characteristics of cathode ray tube (CRT) and liquid crystal display (LCD) monitors influence the retinal biosignal when used as stimulators in ocular electrophysiology. In a conventional CRT monitor, each pixel lights up only for a duration of a few milliseconds during each frame. In contrast, liquid crystal displays are quasi-static, i.e. each pixel has a constant luminance during the whole length of the frame, but lights up only with a certain delay after the trigger. These different display characteristics may affect the mfERG signal. The temporal and spatial luminance distributions of a CRT and an LCD monitor were measured in white flashes. The total amount of emitted light was calculated by integration of the intensity versus time curves. By means of an mfERG recording system (RETIsystem, Roland Consult, Brandenburg, Germany) first-order kernel (FOK) mfERG signals were computed and then analysed using customized MATLAB (TheMathWorks, Natick, MA, USA) software. With the two stimulator monitors, differences in the mfERG signal were observed. The latencies of mfERG responses recorded with the LCD monitor were significantly increased by 7.1 ms for N1 and 9.5 ms for P1 compared to the CRT. Due to a higher luminance, the N1 amplitude was significantly higher by approx. 2 dB in measurements with the LCD monitor while no significant difference could be detected with regard to the more contrast sensitive P1 amplitude. When using LCD monitors as stimulators the increase in latencies and differences in the luminance versus time profile must be taken into account. Prior to clinical application, the establishment of guidelines for the use of LCD monitors is recommended.

  5. Diagnostic hematology of reptiles.

    Science.gov (United States)

    Stacy, Nicole I; Alleman, A Rick; Sayler, Katherine A

    2011-03-01

    The hematologic evaluation of reptiles is an indispensable diagnostic tool in exotic veterinary practice. The diversity of reptile species, their characteristic physiologic features, and effects of intrinsic and extrinsic factors present unique challenges for accurate interpretation of the hemogram. Combining the clinical presentation with hematologic findings provides valuable information in the diagnosis and monitoring of disease and helps guide the clinician toward therapy and further diagnostic testing. This article outlines the normal and pathologic morphology of blood cells of reptile species. The specific comparative aspects of reptiles are emphasized, and structural and functional abnormalities in the reptilian hemogram are described. Copyright © 2011 Elsevier Inc. All rights reserved.

  6. Implementation of an occupational monitoring program in diagnostic radiology at the 'Hospital Universitario Clementino Fraga Filho'; Elaboracao de um programa de monitoracao ocupacional em radiologia para o Hospital Universitario Clementino Fraga Filho

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Sergio Ricardo de; Carvalho, Antonio Carlos Pires [Universidade Federal, Rio de Janeiro, RJ (Brazil). Faculdade de Medicina. Dept. de Radiologia; Azevedo, Ana Cecilia Pedrosa de [Fundacao Instituto Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ (Brazil). Escola Nacional de Saude Publica]. E-mail: acpa@ensp.fiocruz.br

    2003-02-01

    An occupational monitoring program in diagnostic radiology was implemented at the Hospital Clementino Fraga Filho of the Rio de Janeiro Federal University (UFRJ), Brazil, in accordance with the Brazilian legislation. Previously, a survey of all personnel involved with ionizing radiation was performed. Many problems were observed: the great majority of the workers were not properly monitored; only three departments of the hospital kept an independent survey of the occupational doses; there was not a follow-up control of the high doses. With the implementation of the program, a new laboratory was chosen to read the dosemeters and this initiative resulted in reduction of the hospital costs. The inclusion of seven more departments in the program represented an increase of 60% in the number of monitored workers. The program also provided a system to control the high doses, especially in the Hemodynamics department, which presented the highest mean dose value (0.32 mSv/month). An area survey program was performed during different periods in places considered of high risk for the workers and for the public as well. At the same time, a software was used to build a database with the aim of controlling all personnel data. The implementation of the program provided all personnel involved a better knowledge of the risks associated with ionizing radiation and of radioprotection, and also awareness of the need of correct use of the personal dose monitors. (author)

  7. The nature of alarm communication in Constrictotermes cyphergaster (Blattodea: Termitoidea: Termitidae): the integration of chemical and vibroacoustic signals.

    Science.gov (United States)

    Cristaldo, Paulo F; Jandák, Vojtĕch; Kutalová, Kateřina; Rodrigues, Vinícius B; Brothánek, Marek; Jiříček, Ondřej; DeSouza, Og; Šobotník, Jan

    2015-11-04

    Alarm signalling is of paramount importance to communication in all social insects. In termites, vibroacoustic and chemical alarm signalling are bound to operate synergistically but have never been studied simultaneously in a single species. Here, we inspected the functional significance of both communication channels in Constrictotermes cyphergaster (Termitidae: Nasutitermitinae), confirming the hypothesis that these are not exclusive, but rather complementary processes. In natural situations, the alarm predominantly attracts soldiers, which actively search for the source of a disturbance. Laboratory testing revealed that the frontal gland of soldiers produces a rich mixture of terpenoid compounds including an alarm pheromone. Extensive testing led to identification of the alarm pheromone being composed of abundant monoterpene hydrocarbons (1S)-α-pinene and myrcene, along with a minor component, (E)-β-ocimene. The vibratory alarm signalling consists of vibratory movements evidenced as bursts; a series of beats produced predominantly by soldiers. Exposing termite groups to various mixtures containing the alarm pheromone (crushed soldier heads, frontal gland extracts, mixture of all monoterpenes, and the alarm pheromone mixture made of standards) resulted in significantly higher activity in the tested groups and also increased intensity of the vibratory alarm communication, with the responses clearly dose-dependent. Lower doses of the pheromone provoked higher numbers of vibratory signals compared to higher doses. Higher doses induced long-term running of all termites without stops necessary to perform vibratory behaviour. Surprisingly, even crushed worker heads led to low (but significant) increases in the alarm responses, suggesting that other unknown compound in the worker's head is perceived and answered by termites. Our results demonstrate the existence of different alarm levels in termites, with lower levels being communicated through vibratory signals, and

  8. The nature of alarm communication in Constrictotermes cyphergaster (Blattodea: Termitoidea: Termitidae: the integration of chemical and vibroacoustic signals

    Directory of Open Access Journals (Sweden)

    Paulo F. Cristaldo

    2015-12-01

    Full Text Available Alarm signalling is of paramount importance to communication in all social insects. In termites, vibroacoustic and chemical alarm signalling are bound to operate synergistically but have never been studied simultaneously in a single species. Here, we inspected the functional significance of both communication channels in Constrictotermes cyphergaster (Termitidae: Nasutitermitinae, confirming the hypothesis that these are not exclusive, but rather complementary processes. In natural situations, the alarm predominantly attracts soldiers, which actively search for the source of a disturbance. Laboratory testing revealed that the frontal gland of soldiers produces a rich mixture of terpenoid compounds including an alarm pheromone. Extensive testing led to identification of the alarm pheromone being composed of abundant monoterpene hydrocarbons (1S-α-pinene and myrcene, along with a minor component, (E-β-ocimene. The vibratory alarm signalling consists of vibratory movements evidenced as bursts; a series of beats produced predominantly by soldiers. Exposing termite groups to various mixtures containing the alarm pheromone (crushed soldier heads, frontal gland extracts, mixture of all monoterpenes, and the alarm pheromone mixture made of standards resulted in significantly higher activity in the tested groups and also increased intensity of the vibratory alarm communication, with the responses clearly dose-dependent. Lower doses of the pheromone provoked higher numbers of vibratory signals compared to higher doses. Higher doses induced long-term running of all termites without stops necessary to perform vibratory behaviour. Surprisingly, even crushed worker heads led to low (but significant increases in the alarm responses, suggesting that other unknown compound in the worker's head is perceived and answered by termites. Our results demonstrate the existence of different alarm levels in termites, with lower levels being communicated through

  9. SmEdA vibro-acoustic modelling in the mid-frequency range including the effect of dissipative treatments

    Science.gov (United States)

    Hwang, H. D.; Maxit, L.; Ege, K.; Gerges, Y.; Guyader, J.-L.

    2017-04-01

    Vibro-acoustic simulation in the mid-frequency range is of interest for automotive and truck constructors. The dissipative treatments used for noise and vibration control such as viscoelastic patches and acoustic absorbing materials must be taken into account in the problem. The Statistical modal Energy distribution Analysis (SmEdA) model consists in extending Statistical Energy Analysis (SEA) to the mid-frequency range by establishing power balance equations between the modes of the different subsystems. The modal basis of uncoupled-subsystems that can be estimated by the finite element method in the mid-frequency range is used as input data. SmEdA was originally developed by considering constant modal damping factors for each subsystem. However, this means that it cannot describe the local distribution of dissipative materials. To overcome this issue, a methodology is proposed here to take into account the effect of these materials. This methodology is based on the finite element models of the subsystems that include well-known homogenized material models of dissipative treatments. The Galerkin method with subsystem normal modes is used to estimate the modal damping loss factors. Cross-modal coupling terms which appear in the formulation due to the dissipative materials are assumed to be negligible. An approximation of the energy sharing between the subsystems damped by dissipative materials is then described by SmEdA. The different steps of the method are validated experimentally by applying it to a laboratory test case composed of a plate-cavity system with different configurations of dissipative treatments. The comparison between the experimental and the simulation results shows good agreement in the mid-frequency range.

  10. The nature of alarm communication in Constrictotermes cyphergaster (Blattodea: Termitoidea: Termitidae): the integration of chemical and vibroacoustic signals

    Science.gov (United States)

    Cristaldo, Paulo F.; Jandák, Vojtĕch; Kutalová, Kateřina; Rodrigues, Vinícius B.; Brothánek, Marek; Jiříček, Ondřej; DeSouza, Og; Šobotník, Jan

    2015-01-01

    ABSTRACT Alarm signalling is of paramount importance to communication in all social insects. In termites, vibroacoustic and chemical alarm signalling are bound to operate synergistically but have never been studied simultaneously in a single species. Here, we inspected the functional significance of both communication channels in Constrictotermes cyphergaster (Termitidae: Nasutitermitinae), confirming the hypothesis that these are not exclusive, but rather complementary processes. In natural situations, the alarm predominantly attracts soldiers, which actively search for the source of a disturbance. Laboratory testing revealed that the frontal gland of soldiers produces a rich mixture of terpenoid compounds including an alarm pheromone. Extensive testing led to identification of the alarm pheromone being composed of abundant monoterpene hydrocarbons (1S)-α-pinene and myrcene, along with a minor component, (E)-β-ocimene. The vibratory alarm signalling consists of vibratory movements evidenced as bursts; a series of beats produced predominantly by soldiers. Exposing termite groups to various mixtures containing the alarm pheromone (crushed soldier heads, frontal gland extracts, mixture of all monoterpenes, and the alarm pheromone mixture made of standards) resulted in significantly higher activity in the tested groups and also increased intensity of the vibratory alarm communication, with the responses clearly dose-dependent. Lower doses of the pheromone provoked higher numbers of vibratory signals compared to higher doses. Higher doses induced long-term running of all termites without stops necessary to perform vibratory behaviour. Surprisingly, even crushed worker heads led to low (but significant) increases in the alarm responses, suggesting that other unknown compound in the worker's head is perceived and answered by termites. Our results demonstrate the existence of different alarm levels in termites, with lower levels being communicated through vibratory

  11. Vibroacoustics of the piano soundboard: (Non)linearity and modal properties in the low- and mid-frequency ranges

    Science.gov (United States)

    Ege, Kerem; Boutillon, Xavier; Rébillat, Marc

    2013-03-01

    The piano soundboard transforms the string vibration into sound and therefore, its vibrations are of primary importance for the sound characteristics of the instrument. An original vibro-acoustical method is presented to isolate the soundboard nonlinearity from that of the exciting device (here: a loudspeaker) and to measure it. The nonlinear part of the soundboard response to an external excitation is quantitatively estimated for the first time, at ≈-40 dB below the linear part at the ff nuance. Given this essentially linear response, a modal identification is performed up to 3 kHz by means of a novel high resolution modal analysis technique [K. Ege, X. Boutillon, B. David, High-resolution modal analysis, Journal of Sound and Vibration 325 (4-5) (2009) 852-869]. Modal dampings (which, so far, were unknown for the piano in this frequency range) are determined in the mid-frequency domain where FFT-based methods fail to evaluate them with an acceptable precision. They turn out to be close to those imposed by wood. A finite-element modelling of the soundboard is also presented. The low-order modal shapes and the comparison between the corresponding experimental and numerical modal frequencies suggest that the boundary conditions can be considered as blocked, except at very low frequencies. The frequency-dependency of the estimated modal densities and the observation of modal shapes reveal two well-separated regimes. Below ≈1 kHz, the soundboard vibrates more or less like a homogeneous plate. Above that limit, the structural waves are confined by ribs, as already noticed by several authors, and localised in restricted areas (one or a few inter-rib spaces), presumably due to a slightly irregular spacing of the ribs across the soundboard.

  12. Circulating Cell-Free DNA in Plasma of Locally Advanced Rectal Cancer Patients Undergoing Preoperative Chemoradiation: A Potential Diagnostic Tool for Therapy Monitoring

    Directory of Open Access Journals (Sweden)

    Matthias Zitt

    2008-01-01

    Full Text Available Circulating cell-free DNA opens up an interesting field for therapy monitoring, in particular during multimodal therapy protocols. The objective of this proof of principle study was to evaluate whether the amount of circulating plasma DNA has the potential to serve as a marker for therapy monitoring during the treatment course of locally advanced rectal cancer patients. We especially focused on kinetics of circulating DNA to assess whether variances in kinetics have the potential to discriminate between therapy responders and nonresponders.

  13. CD4 lymphocyte counts and serum p24 antigen of no diagnostic value in monitoring HIV-infected patients with pulmonary symptoms

    DEFF Research Database (Denmark)

    Orholm, M; Nielsen, T L; Nielsen, Jens Ole

    1990-01-01

    The diagnostic value of the CD4 cell counts and the HIV p24 antigen were evaluated in a consecutive series of 105 HIV-infected patients experiencing 128 episodes of pulmonary symptoms which required bronchoscopy. One-third of patients with opportunistic infection (OI) had CD4 counts greater than 0....... In conclusion, the CD4 cell counts and the presence of p24 antigen in serum had a very limited predictive value for the presence of OI in HIV-infected patients with pulmonary symptoms....

  14. Beamlet laser diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Burkhart, S.C.; Behrendt, W.C.; Smith, I.

    1996-06-01

    Beamlet is instrumented extensively to monitor the performance of the overall laser system and many of its subsystems. Beam diagnostics, installed in key locations, are used to fully characterize the beam during its propagation through the multipass cavity and the laser`s output section. This article describes the diagnostics stations located on Beamlet and discusses the design, calibration, and performance of the Beamlet calorimeters. The authors used Nova`s diagnostics packages to develop the Beamlet design to determine beam energy, spatial profile, temporal profile, and other beam parameters. Technologic improvements within the last several years in controls, charge-coupled device (CCD) cameras, and fast oscilloscopes have allowed the authors to obtain more accurate measurements on the Beamlet laser system. They briefly cover some of these techniques, including a description of their LabVIEW based data acquisition system.

  15. MONITORING OF CUTTING CONDITIONS WITH THE EMPIRICAL MODE DECOMPOSITION

    Directory of Open Access Journals (Sweden)

    Piotr Krzysztof Wolszczak

    2017-03-01

    Full Text Available In this paper we apply empirical mode decomposition by Huang and Hilbert transform to signals recorded during a milling process. Vibroacoustic sensors recorded vibrations of a tool-workpiece system while milling with the end mill of a special shape of "Hi-Feed." The results of Huang-Hilbert analysis provides the information about amplitudes and frequencies of the empirical modal components. Application of Huang-Hilbert transform to cutting conditions monitoring allows the separation of various vibration components caused by the phenomena associated the drive system and the machine components. Therefore, the analysis highlights the vibrations caused by known sources of vibration, such as spindle speed, the number of teeth of the cutting tool or the frequency of vibration tools. Furthermore, signal components generated in the cutting zone were identified. The resulting information helps to assess the working conditions of cutting tools, selection of cutting parameters and tool wear monitoring.

  16. Embedded diagnostics in combat systems

    Science.gov (United States)

    Miles, Christopher; Bankowski, Elena N.

    2004-07-01

    Diagnostics capability of combat systems shall be compatible with the Army Diagnostic Improvement Program. Present systems are capable of performing health monitoring and health checks using internal embedded resources. They employ standard sensors and data busses that monitor data signals and built-in test (BIT). These devices provide a comprehensive source of data to accomplish an accurate system level diagnostics and fault isolation at line replaceable unit (LRU) level. Prognostics routines provide capability to identify the cause of predicted failure and corrective action to prevent unscheduled maintenance action. Combat system"s health status and prognostic information are displayed to operator, crew, and maintenance personnel. Present systems use common data/information interchange network in accordance with standards defined in the Joint Technical Architecture (JTA) to provide access to vehicle"s health data. The technologies utilized in present systems include embedded diagnostics, combat maintainer, schematic viewer, etc. Implementation of these technologies significantly reduced maintenance hours of combat systems. Health monitoring, diagnostics and prognostics of future systems will utilize federated software and probes approach. Gauges will determine if the system operates within acceptable performance bands by monitoring data provided by the probes. Health monitoring system will use models of missions to make intelligent choices considering tasks criticality.

  17. CD4 lymphocyte counts and serum p24 antigen of no diagnostic value in monitoring HIV-infected patients with pulmonary symptoms

    DEFF Research Database (Denmark)

    Orholm, M; Nielsen, T L; Nielsen, Jens Ole

    1990-01-01

    .200 x 10(9)/l, and 60% of patients without OI had CD4 counts less than 0.200 x 10(9)/l; 47 and 42% of patients with and without OI, respectively, had detectable p24 antigen in serum. Only 36% of the patients with OI presented the combination of CD4 cells less than 0.200 x 10(9)/l and p24 in serum......The diagnostic value of the CD4 cell counts and the HIV p24 antigen were evaluated in a consecutive series of 105 HIV-infected patients experiencing 128 episodes of pulmonary symptoms which required bronchoscopy. One-third of patients with opportunistic infection (OI) had CD4 counts greater than 0....... In conclusion, the CD4 cell counts and the presence of p24 antigen in serum had a very limited predictive value for the presence of OI in HIV-infected patients with pulmonary symptoms....

  18. Detection Damage in Bearing System of Jet Engine Using the Vibroacoustic Method

    Directory of Open Access Journals (Sweden)

    Żokowski Mariusz

    2017-09-01

    Full Text Available The article discusses typical, operational systems for monitoring vibrations of jet engines, which constitute the propulsion of combat aircraft of the Armed Forces of the Republic of Poland. After that, the paper presents the stage of installing vibration measuring sensors in the direct area of one of the jet engine bearings, which is a support system for its rotor. The article discusses results of carried out analyses of data gathered during tests of the engine in the conditions a jet engine test bed. Results of detecting damages to the bear-ing, using sensors built in the direct area will be presented.

  19. Point -of -care testing (POCT) in molecular diagnostics: Performance evaluation of GeneXpert HCV RNA test in diagnosing and monitoring of HCV infection.

    Science.gov (United States)

    Gupta, Ekta; Agarwala, Pragya; Kumar, Guresh; Maiwall, Rakhi; Sarin, Shiv Kumar

    2017-03-01

    Molecular testing at the point-of-care may turn out to be game changer for HCV diagnosis and treatment monitoring, through increased sensitivity, reduced turnaround time, and ease of performance. One such assay GeneXpert(®) has recently been released. Comparative analysis between performances of GeneXpert(®) and Abbott HCV-RNA was done. 174 HCV infected patients were recruited and, one time plasma samples from 154 patients and repeated samples from 20 patients, obtained at specific treatment time-points (0, 4, 12 and 24) weeks were serially re-tested on Xpert(®). Genotype 3 was the commonest, seen in 80 (66%) of the cases, genotype 1 in 34 (28.3%), genotype 4 in 4 (3.3%) and genotypes 2 and 5 in 1 (0.8%) each. Median HCV RNA load was 4.69 log10 (range: 0-6.98log10) IU/ml. Overall a very good correlation was seen between the two assays (R(2)=0.985), concordance of the results between the assays was seen in 138 samples (89.6%). High and low positive standards were tested ten times on Xpert(®) to evaluate the precision and the coefficient of variation was 0.01 for HPC and 0.07 for the LPC. Monitoring of patients on two different regimes of treatment, pegylated interferon plus ribavirin and sofosbuvir plus ribavirin was done by both the systems at baseline, 4, 12 and 24 weeks. Perfect correlation between the assays in the course of therapy at different treatment time- point in genotypes 3 and 1 was seen. The study demonstrates excellent performance of the Xpert(®) HCV assay in viral load assessment and in treatment course monitoring consistency. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. The added diagnostic value of postreflux swallow-induced peristaltic wave index and nocturnal baseline impedance in refractory reflux disease studied with on-therapy impedance-pH monitoring.

    Science.gov (United States)

    Frazzoni, M; de Bortoli, N; Frazzoni, L; Tolone, S; Furnari, M; Martinucci, I; Mirante, V G; Marchi, S; Savarino, V; Savarino, E

    2017-03-01

    On-therapy impedance-pH monitoring in proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) yielded conflicting results. We aimed to assess the diagnostic value of postreflux swallow-induced peristaltic wave (PSPW) index and mean nocturnal baseline impedance (MNBI) in PPI-refractory heartburn. On-therapy impedance-pH tracings from 189 consecutive patients with PPI-refractory heartburn were blindly reviewed. Patients were subdivided into refractory reflux esophagitis (RRE), healed reflux esophagitis (HRE), non-erosive reflux disease (NERD), and functional heartburn (FH) according to endoscopic and conventional impedance-pH findings. The diagnostic accuracy of PSPW index and MNBI in separating NERD from FH was assessed with receiver-operating-characteristic (ROC) analysis. Objectively documented persistent reflux remission at 3-year follow-up in 53 patients who underwent laparoscopic fundoplication served to evaluate PSPW index and MNBI as independent predictors of PPI-refractory GERD confirmed by positive surgical outcome. Median PSPW index and MNBI values were significantly lower in 39 RRE (16%; 1145 Ω) than in 41 HRE (25%; 1741 Ω) and in 68 NERD (29%; 2374 Ω) patients, and in all three GERD subgroups compared to 41 FH cases (67%; 3488 Ω) (Prefractory GERD (odds ratio 0.6983, P=.012). At on-therapy impedance-pH monitoring, PSPW index and MNBI efficiently distinguish PPI-refractory NERD from FH. The PSPW index represents an independent predictor of PPI-refractory GERD. © 2016 John Wiley & Sons Ltd.

  1. The clinical psychological diagnostic system (KPD-38): sensitivity to change and validity of a self-report instrument for outcome monitoring and quality assurance.

    Science.gov (United States)

    Moessner, Markus; Gallas, Christine; Haug, Severin; Kordy, Hand

    2011-01-01

    Monitoring psychotherapeutic progress requires valid and economic measures to detect change of clinical relevance. We addressed validity and sensitivity to change of the 'Klinisch Psychologisches Diagnosesystem 38' (KPD-38, Clinical Psychological Diagnosis System), an instrument for outcome monitoring and quality assurance. Data from an inpatient sample (n = 1.377) were used to investigate the concurrent validity, the sensitivity to change, and the criterion validity of the KPD-38 in comparison to the Outcome Questionnaire (OQ-45) and the Brief Symptom Inventory (BSI). Sensitivity-specificity analyses showed similar sensitivity and higher specificity for the KPD-38 scales compared with the BSI and OQ total scores. Change rates on the KPD-38 distress scale (DIS) were found to be lower than on the BSI (KPD-38 DIS: 36.6%, GSI: 67.7%) and the OQ-45 (KPD-38 DIS: 44.3%, OQ tot: 57.1%) total scores. Concordance was low with the BSI ([κ = 0.24] and moderate with the OQ-45 [κ = 0.45]). Implications for applications in the field of outcome assessment and the challenge of further validation are discussed. The relation between sensitivity to change and criterion validity is highlighted. Copyright © 2010 John Wiley & Sons, Ltd.

  2. Saliva as a diagnostic fluid.

    Science.gov (United States)

    Malamud, Daniel

    2011-01-01

    Salivary diagnostics is a dynamic and emerging field utilizing nanotechnology and molecular diagnostics to aid in the diagnosis of oral and systemic diseases. In this article the author critically reviews the latest advances using oral biomarkers for disease detection. The use of oral fluids is broadening perspectives in clinical diagnosis, disease monitoring, and decision making for patient care. Important elements determining the future possibilities and challenges in this field are also discussed. Copyright © 2011 Elsevier Inc. All rights reserved.

  3. Saliva as a Diagnostic Fluid

    OpenAIRE

    Malamud, Daniel; Rodriguez-Chavez, Isaac R.

    2011-01-01

    Salivary diagnostics is a dynamic and emerging field utilizing nanotechnology and molecular diagnostics to aid in the diagnosis of oral and systemic diseases. Here, we critically review the latest advances using oral biomarkers for disease detection. The use of oral fluids is broadening perspectives in clinical diagnosis, disease monitoring and decision making for patient care. Important elements determining the future possibilities and challenges in this field are also discussed.

  4. Four-channel accelerometer for diagnostic testing of roller bearings of mine blowers

    Energy Technology Data Exchange (ETDEWEB)

    Lebiedzki, A.

    1992-01-01

    Discusses design, operation and use of a four-channel vibroacoustic monitoring system for control of the main blowers driven by electric motors with a revolution rate of 500 rpm and 1 MW power. The PPWa-22PN piezoelectric acceleration converters manufactured by the EKCEL plant in Katowice were used. The converters were equipped with built-in preamplifiers that enabled measuring cables up to 100 m long to be used. The converters were mounted on the casings of blower roller bearings. Rising acoustic emission and mechanical vibrations measured and recorded by the system were signalled to a driver by three lamps (green, yellow and red ones) showing acoustic emission increase by 2 dB, 4 dB or 6 dB. Reliability of blower control using the system is discussed. 3 refs.

  5. Companion diagnostics

    DEFF Research Database (Denmark)

    Jørgensen, Jan Trøst; Hersom, Maria

    2016-01-01

    . Despite having discussed personalized medicine for more than a decade, we still see that most drug prescriptions for severe chronic diseases are largely based on 'trial and error' and not on solid biomarker data. However, with the advance of molecular diagnostics and a subsequent increased understanding...

  6. Development and Evaluation of Sensor Concepts for Ageless Aerospace Vehicles: Report 6 - Development and Demonstration of a Self-Organizing Diagnostic System for Structural Health Monitoring

    Science.gov (United States)

    Batten, Adam; Edwards, Graeme; Gerasimov, Vadim; Hoschke, Nigel; Isaacs, Peter; Lewis, Chris; Moore, Richard; Oppolzer, Florien; Price, Don; Prokopenko, Mikhail; hide

    2010-01-01

    This report describes a significant advance in the capability of the CSIRO/NASA structural health monitoring Concept Demonstrator (CD). The main thrust of the work has been the development of a mobile robotic agent, and the hardware and software modifications and developments required to enable the demonstrator to operate as a single, self-organizing, multi-agent system. This single-robot system is seen as the forerunner of a system in which larger numbers of small robots perform inspection and repair tasks cooperatively, by self-organization. While the goal of demonstrating self-organized damage diagnosis was not fully achieved in the time available, much of the work required for the final element that enables the robot to point the video camera and transmit an image has been completed. A demonstration video of the CD and robotic systems operating will be made and forwarded to NASA.

  7. Computation of leaky guided waves dispersion spectrum using vibroacoustic analyses and the Matrix Pencil Method: a validation study for immersed rectangular waveguides.

    Science.gov (United States)

    Mazzotti, M; Bartoli, I; Castellazzi, G; Marzani, A

    2014-09-01

    The paper aims at validating a recently proposed Semi Analytical Finite Element (SAFE) formulation coupled with a 2.5D Boundary Element Method (2.5D BEM) for the extraction of dispersion data in immersed waveguides of generic cross-section. To this end, three-dimensional vibroacoustic analyses are carried out on two waveguides of square and rectangular cross-section immersed in water using the commercial Finite Element software Abaqus/Explicit. Real wavenumber and attenuation dispersive data are extracted by means of a modified Matrix Pencil Method. It is demonstrated that the results obtained using the two techniques are in very good agreement. Copyright © 2014 Elsevier B.V. All rights reserved.

  8. Antenatal fetal assessment: contraction stress test, nonstress test, vibroacoustic stimulation, amniotic fluid volume, biophysical profile, and modified biophysical profile--an overview.

    Science.gov (United States)

    Devoe, Lawrence D

    2008-08-01

    Antenatal fetal assessment was introduced into the United States in the 1970s. The initial antepartum test, the oxytocin challenge test, later renamed as the contraction stress test, became the gold standard for fetal surveillance. Its labor intensive requirements and contraindications made it inapplicable to some high-risk pregnancies. Other testing schemes were developed subsequently, the nonstress test and its alternative, vibroacoustic stimulation, the semiquantitative assessment of amniotic fluid volume, the biophysical profile and its modified version, the modified biophysical profile. This article is a brief critical review of these testing methods and focuses on the following: (1) physiologic bases; (2) testing methodologies; (3) supportive evidence from randomized controlled and observational trials; and (4) areas needing further investigation.

  9. Would turbine uprating be allowable with respect to cavitation? An example of vibroacoustic diagnosis; Turbinenleistungserhoehung - Waere sie zulaessig im Hinblick auf die Kavitation? Beispiel einer vibroakustischen Diagnose

    Energy Technology Data Exchange (ETDEWEB)

    Bajic, B.

    1999-04-01

    Velocity field disturbances at the inflow to the runner of a turbine caused by the stay and guide vanes alter the vibroacoustic cavitation signature. This telltale amplitude modulation can be a means to identify the incipient, weak, or moderate cavitation related to each vane/runner blade pair. An application of this method is presented identifying the turbine parts responsible for the increase of cavitation predicted when uprating a 60 MW Kaplan turbine. (orig.) [German] Stoerungen im Geschwindigkeitsfeld am Einlauf zu einem Turbinenlaufrad, hervorgerufen durch die Stuetz- und Leitschaufeln, veraendern die vibroakustischen Kavitationsanzeichen. Diese aussagekraeftige Amplitudenmodulation kann herangezogen werden, um die beginnende, schwache oder mittelmaessige Kavitation fuer jedes Paar aus Leitschaufel (Stuetz- und Leitschaufel) und Laufradschaufel zu bestimmen. Hier wird ein Anwendungsbeispiel dieser Methode vorgestellt, wobei diejenigen Turbinenteile identifiziert werden, die fuer die vorhergesagte Zunahme der Kavitation im Falle der Nennleistungserhoehung einer 60 MW Kaplan-Turbine verantwortlich sind. (orig.)

  10. Combination of vibroacoustic stimulation and acute variables of mFBP as a simple assessment method of low-risk fetuses.

    Science.gov (United States)

    Petrović, Oleg; Finderle, Aleks; Prodan, Mirko; Skunca, Elvira; Prpić, Igor; Zaputović, Sanja

    2009-02-01

    To observe a rate of fetal breathing and gross body movement appearance as physiologic reactions to the external vibroacoustic stimulation (VAS) and to establish a rapid and reliable antepartal method for accurate selecting of non-compromised fetuses in the low-risk population. Actual condition of 742-term and near-term structurally normal and otherwise healthy singleton fetuses with favourable outcome was assessed by previously established combination of the modified fetal biophysical profile and VAS. Only inactive fetuses at the beginning of the testing were included in the study. The combined biophysical testing has been started by a transabdominal real-time ultrasound examination, followed by vibroacoustic stimulus applied over the fetal head for 5 s during fetal quiescence. Fetal breathing and gross body movements were observed with particular attention in each case at measured time intervals from the application of external VAS until the moment at which either the first 60-s episode of breathing movements or all three fetal gross body movements were detected. Obtained results have been presented numerically in 5-min periods and cumulative percentages. After the external VAS, 84.5% of studied fetuses successfully manifested their normal breathing or gross body movements in the first 5 min of the modified biophysical testing. Furthermore, approximately 96% of them were able to demonstrate at least one of these two biophysical activities after 6-7 min. Because of its simplicity, non-invasiveness, independence of precise gestational dating, reproducibility and immediate individual results, ultrasonographic observation of normal fetal breathing and/or gross body movements after the external VAS stands a real chance to become a nearly optimal antenatal test for accurate and rapid information of actual non-compromised fetal condition. Authors strongly believe that the described antenatal method should represent a rather efficient assessment procedure of fetal well

  11. Ozone-Depleting Gases in the Atmosphere: Results From 28 Years of Measurements by the NOAA Climate Monitoring and Diagnostics Laboratory (CMDL)

    Science.gov (United States)

    Hurst, D. F.; Elkins, J. W.; Montzka, S. A.; Butler, J. H.; Dutton, G. S.; Hall, B. D.; Mondeel, D. J.; Moore, F. L.; Nance, J. D.; Romashkin, P. A.; Thompson, T. M.

    2005-12-01

    Back in 1978, NOAA/CMDL initiated the weekly filling of flasks at CMDL observatories in Alaska, Hawaii, American Samoa, and Antarctica for analyses of CFC-11, CFC-12 and N2O in the home laboratory. A decade later, each observatory was outfitted with an automated gas chromatograph to make routine, in situ measurements of these three source gases plus methyl chloroform and carbon tetrachloride. Both measurement programs are ongoing, having expanded over the years to include methyl halides and substitutes for regulated halocarbons, to presently account for 95% of the total burden of long-lived Cl and Br believed to enter the stratosphere. These long-term monitoring data have been assimilated into temporal records of the global tropospheric burdens of ozone-depleting chlorine and bromine which are critical input to models that predict future trends in stratospheric ozone. Other information pivotal to ozone projections, such as the atmospheric lifetimes of source gases, stratospheric entry values for total chlorine and total bromine, and identification of the stratospheric sink regions for long-lived source gases, has been gained from in situ measurements by NOAA/CMDL instruments aboard NASA high-altitude aircraft (ER-2 and WB-57) and balloons since 1991. Though CMDL's routine monitoring activities provide important historical records of halogenated source gases in the atmosphere, significant inaccuracies in ozone projections may propagate from the uncertain estimates of impending emissions of ozone-depleting gases. Scenarios of future halocarbon emissions require substantial assumptions about past and pending compliance with the Montreal Protocol, and the sizes and release rates of existing global reservoirs (banks) of halocarbons. Recent work by CMDL has focused on quantifying halocarbon bank emission rates in Russia, the USA, and Canada through geographically extensive measurements aboard trains and low-altitude aircraft. The USA and Canada results indicate that

  12. Clinical Utility of Ammonia Concentration as a Diagnostic Test in Monitoring of the Treatment with L-Asparaginase in Children with Acute Lymphoblastic Leukemia

    Directory of Open Access Journals (Sweden)

    Małgorzata Czogała

    2014-01-01

    Full Text Available L-asparaginase (ASP is an enzyme used as one of the basic regimens in the acute lymphoblastic leukemia (ALL therapy. Because of the possibility of the enzyme inactivation by antibodies, monitoring of ASP activity is essential. The aim of the study was to examine if plasma concentration of ammonia, a direct product of the reaction catalyzed by ASP, can be used in the assessment of ASP activity. A group of 87 patients with acute lymphoblastic leukemia treated in the Department of Pediatric Oncology and Hematology in Krakow was enrolled to the study. ASP activity and ammonia concentration were measured after ASP administrations during induction. A positive correlation was found between the ammonia concentration and ASP activity (R=0.44; P<0.0001 and between the medium values of ammonia concentration and ASP activity (R=0.56; P<0.0001. The analysis of ROC curves revealed the moderate accuracy of the ammonia concentration values in the ASP activity assessment. It was also found that the medium value of ammonia concentrations can be useful in identification of the patients with low (<100 IU/L and undetectable (<30 IU/L ASP activity. The plasma ammonia concentration may reflect ASP activity and can be useful when a direct measurement of the activity is unavailable.

  13. Strategies for the Assessment of Metabolic Profiles of Steroid Hormones in View of Diagnostics and Drug Monitoring: Analytical Problems and Challenges.

    Science.gov (United States)

    Plenis, Alina; Oledzka, Ilona; Kowalski, Piotr; Baczek, Tomasz

    2016-01-01

    During the last few years there has been a growing interest in research focused on the metabolism of steroid hormones despite that the study of metabolic hormone pathways is still a difficult and demanding task because of low steroid concentrations and a complexity of the analysed matrices. Thus, there has been an increasing interest in the development of new, more selective and sensitive methods for monitoring these compounds in biological samples. A lot of bibliographic databases for world research literature were structurally searched using selected review question and inclusion/exclusion criteria. Next, the reports of the highest quality were selected using standard tools (181) and they were described to evaluate the advantages and limitations of different approaches in the measurements of the steroids and their metabolites. The overview of the analytical challenges, development of methods used in the assessment of the metabolic pathways of steroid hormones, and the priorities for future research with a special consideration for liquid chromatography (LC) and capillary electrophoresis (CE) techniques have been presented. Moreover, many LC and CE applications in pharmacological and psychological studies as well as endocrinology and sports medicine, taking into account the recent progress in the area of the metabolic profiling of steroids, have been critically discussed. The latest reports show that LC systems coupled with mass spectrometry have the predominant position in the research of steroid profiles. Moreover, CE techniques are going to gain a prominent position in the diagnosis of hormone levels in the near future.

  14. Vibro-acoustic methods for the determination of the technical state of a refrigeration piston compressor. A check-up for the compressor. Vibroakustische Verfahren zur Bestimmung des technischen Zustandes eines Kaeltekolbenverdichters. Ein Check-up fuer den Verdichter

    Energy Technology Data Exchange (ETDEWEB)

    Milowanow, V.I.; Lopatinskaja, E.S.

    1990-10-01

    Independent of the kind of refrigeration plant the actual service life is limited by the service life of the compressor. In case of refrigeration machinery with small-type refrigeration compressors for refrigerated transport systems a periodical check of the system before setting out is particularly important. A spectral analysis process is recommended for the diagnosis. But due to the particularities of the plants this is only suited for systems for vibroacoustic diagnosis. This technique is presented using charts and diagrams. (BWI).

  15. Monitoring pharmacologically induced immunosuppression by immune repertoire sequencing to detect acute allograft rejection in heart transplant patients: a proof-of-concept diagnostic accuracy study.

    Directory of Open Access Journals (Sweden)

    Christopher Vollmers

    2015-10-01

    Full Text Available It remains difficult to predict and to measure the efficacy of pharmacological immunosuppression. We hypothesized that measuring the B-cell repertoire would enable assessment of the overall level of immunosuppression after heart transplantation.In this proof-of-concept study, we implemented a molecular-barcode-based immune repertoire sequencing assay that sensitively and accurately measures the isotype and clonal composition of the circulating B cell repertoire. We used this assay to measure the temporal response of the B cell repertoire to immunosuppression after heart transplantation. We selected a subset of 12 participants from a larger prospective cohort study (ClinicalTrials.gov NCT01985412 that is ongoing at Stanford Medical Center and for which enrollment started in March 2010. This subset of 12 participants was selected to represent post-heart-transplant events, with and without acute rejection (six participants with moderate-to-severe rejection and six without. We analyzed 130 samples from these patients, with an average follow-up period of 15 mo. Immune repertoire sequencing enables the measurement of a patient's net state of immunosuppression (correlation with tacrolimus level, r = -0.867, 95% CI -0.968 to -0.523, p = 0.0014, as well as the diagnosis of acute allograft rejection, which is preceded by increased immune activity with a sensitivity of 71.4% (95% CI 30.3% to 94.9% and a specificity of 82.0% (95% CI 72.1% to 89.1% (cell-free donor-derived DNA as noninvasive gold standard. To illustrate the potential of immune repertoire sequencing to monitor atypical post-transplant trajectories, we analyzed two more patients, one with chronic infections and one with amyloidosis. A larger, prospective study will be needed to validate the power of immune repertoire sequencing to predict rejection events, as this proof-of-concept study is limited to a small number of patients who were selected based on several criteria including the

  16. Diagnostic Challenges at SNS

    CERN Document Server

    Plum, M A

    2003-01-01

    The Spallation Neutron Source now being built in Oak Ridge, Tennessee, USA, accelerates an H- ion beam to 1000 MeV with an average power of 1.4 MW. The H- beam is then stripped to H+, compressed in a storage ring to a pulse length of 695 ns, and then directed onto a mercury neutron spallation target. Most of the acceleration is accomplished with superconducting rf cavities. The presence of these cavities, the high average beam power, and the large range of beam intensity in the storage ring, provide unique challenges to the beam diagnostics systems. In this talk we will discuss these challenges and some of our solutions, including the laser profile monitor system, the residual gas ionization profile monitors, and network attached devices. Measurements performed using prototype instrumentation will also be presented.

  17. Diagnostic performance of detecting breast cancer on computed radiographic (CR) mammograms: comparison of hard copy film, 3-megapixel liquid-crystal-display (LCD) monitor and 5-megapixel LCD monitor.

    Science.gov (United States)

    Yamada, Takayuki; Suzuki, Akihiko; Uchiyama, Nachiko; Ohuchi, Noriaki; Takahashi, Shoki

    2008-11-01

    The purpose was to compare observer performance in the detection of breast cancer using hard-copy film, and 3-megapixel (3-MP) and 5-megapixel (5-MP) liquid crystal display (LCD) monitors in a simulated screening setting. We amassed 100 sample sets, including 32 patients with surgically proven breast cancer (masses present, N = 12; microcalcifications, N = 10; other types, N = 10) and 68 normal controls. All the mammograms were obtained using computed radiography (CR; sampling pitch of 50 mum). Twelve mammographers independently assessed CR mammograms presented in random order for hard-copy and soft-copy reading at minimal 4-week intervals. Observers rated the images on seven-point (1 to 7) and continuous (0 to 100) malignancy scales. Receiver-operating-characteristics analysis was performed, and the average area under the curve (AUC) was calculated for each modality. The jackknife method with the Bonferroni correction was applied to multireader/multicase analysis. The average AUC values for the 3-MP LCD, 5-MP LCD, and hard-copy film were 0.954, 0.947, and 0.956 on the seven-point scale and 0.943, 0.923, and 0.944 on the continuous scale, respectively. There were no significant differences among the three modalities on either scale. Soft-copy reading using 3-MP and 5-MP LCDs is comparable to hard-copy reading for detecting breast cancer.

  18. Thyroid diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Scriba, P.C.; Boerner, W.; Emrich, S.; Gutekunst, R.; Herrmann, J.; Horn, K.; Klett, M.; Krueskemper, H.L.; Pfannenstiel, P.; Pickardt, C.R.

    1985-03-01

    None of the in-vitro and in-vivo methods listed permits on unambiguous diagnosis when applied alone, owing to the fact that similar or even identical findings are obtained for various individual parameters in different thyroid diseases. Further, especially the in-vitro tests are also subject to extrathyroidal effects which may mask the typical findings. The limited and varying specificity and sensitivity of the tests applied, as well as the falsification of results caused by the patients' idiosyncracies and the methodology, make it necessary to interpret and evaluate the in-vivo and in-vitro findings only if the clinical situation (anamnesis and physical examination) is known. For maximum diagnostic quality of the tests, the initial probability of the assumed type of thyroid disease must be increased (formulation of the clinical problem). The concepts of exclusion diagnosis and identification must be distinguished as well as the diagnosis of functional disturbances on the one hand and of thyroid diseases on the other. Both of this requires a qualified, specific and detailed anamnesis and examination procedure, and the clinical examination remains the obligatory basis of clinical diagnostics. In case of inexplicable discrepancies between the clinical manifestations and the findings obtained with specific methods, or between the findings obtained with a specific method, the patient should be referred to an expert institution, or the expert institution should be consulted.

  19. Ambient diagnostics

    CERN Document Server

    Cai, Yang

    2014-01-01

    Part I. FundamentalsIntroductionWhat is Ambient Diagnostics?Diagnostic ModelsMultimedia IntelligenceCrowd SourcingSoft SensorsScience of SimplicityPersonal DiagnosesBasic AlgorithmsBasic ToolsSummaryProblemsTransformationEarly Discoveries of Heartbeat PatternsTransforms, Features, and AttributesSequential FeaturesSpatiotemporal FeaturesShape FeaturesImagery FeaturesFrequency Domain FeaturesMulti-Resolution FeaturesSummaryProblemsPattern RecognitionSimilarities and DistancesClustering MethodsClassification MethodsClassifier Accuracy MeasuresSummaryProblemsPart II. Multimedia IntelligenceSound RecognitionMicrophone AppsModern Acoustic Transducers (Microphones)Frequency Response CharacteristicsDigital Audio File FormatsHeart Sound SensingLung Sound SensingSnore MeterSpectrogram (STFT)Ambient Sound AnalysisSound RecognitionRecognizing Asthma SoundPeak ShiftFeature CompressionRegroupingNoise IssuesFuture ApplicationsSummaryProblemsColor SensorsColor SensingHuman Color VisionColor SensorsColor Matching ExperimentsC...

  20. Transformer engineering design, technology, and diagnostics

    CERN Document Server

    Kulkarni, SV

    2012-01-01

    Transformer Engineering: Design, Technology, and Diagnostics, Second Edition helps you design better transformers, apply advanced numerical field computations more effectively, and tackle operational and maintenance issues. Building on the bestselling Transformer Engineering: Design and Practice, this greatly expanded second edition also emphasizes diagnostic aspects and transformer-system interactions. What's New in This Edition Three new chapters on electromagnetic fields in transformers, transformer-system interactions and modeling, and monitoring and diagnostics An extensively revised chap

  1. Clay as Thermoluminescence Dosemeter in diagnostic Radiology ...

    African Journals Online (AJOL)

    This paper reports the investigation of the basic thermoluminescence properties of clay at x-rays in the diagnostic radiology range, including dose monitoring in abdominal radiography. Clay sourced from Calabar, Nigeria, was tested for thermoluminescence response after irradiation at diagnostic radiology doses, including ...

  2. Glucosylsphingosine is a highly sensitive and specific biomarker for primary diagnostic and follow-up monitoring in Gaucher disease in a non-Jewish, Caucasian cohort of Gaucher disease patients.

    Directory of Open Access Journals (Sweden)

    Arndt Rolfs

    Full Text Available Gaucher disease (GD is the most common lysosomal storage disorder (LSD. Based on a deficient β-glucocerebrosidase it leads to an accumulation of glucosylceramide. Standard diagnostic procedures include measurement of enzyme activity, genetic testing as well as analysis of chitotriosidase and CCL18/PARC as biomarkers. Even though chitotriosidase is the most well-established biomarker in GD, it is not specific for GD. Furthermore, it may be false negative in a significant percentage of GD patients due to mutation. Additionally, chitotriosidase reflects the changes in the course of the disease belatedly. This further enhances the need for a reliable biomarker, especially for the monitoring of the disease and the impact of potential treatments.Here, we evaluated the sensitivity and specificity of the previously reported biomarker Glucosylsphingosine with regard to different control groups (healthy control vs. GD carriers vs. other LSDs.Only GD patients displayed elevated levels of Glucosylsphingosine higher than 12 ng/ml whereas the comparison controls groups revealed concentrations below the pathological cut-off, verifying the specificity of Glucosylsphingosine as a biomarker for GD. In addition, we evaluated the biomarker before and during enzyme replacement therapy (ERT in 19 patients, demonstrating a decrease in Glucosylsphingosine over time with the most pronounced reduction within the first 6 months of ERT. Furthermore, our data reveals a correlation between the medical consequence of specific mutations and Glucosylsphingosine.In summary, Glucosylsphingosine is a very promising, reliable and specific biomarker for GD.

  3. Functional MRI in schizophrenia. Diagnostics and therapy monitoring of cognitive deficits of schizophrenic patients by functional MRI; Funktionelle MRT bei Schizophreniepatienten. Diagnostik und Therapiemonitoring kognitiver Defizite schizophrener Patienten mittels funktioneller MRT

    Energy Technology Data Exchange (ETDEWEB)

    Furtner, J.; Prayer, D. [Medizinische Universitaet Wien, Univ.-Klinik fuer Radiodiagnostik, Wien (Austria); Sachs, G. [Medizinische Universitaet Wien, Univ.-Klinik fuer Psychiatrie und Psychotherapie, Wien (Austria)

    2010-02-15

    Cognitive impairments are core psychopathological components of the symptomatic of schizophrenic patients. These dysfunctions are generally related to attention, executive functions and memory. This report provides information on the importance of using functional magnetic resonance imaging (fMRI) for the diagnostics and therapy monitoring of the different subtypes of cognitive dysfunctions. Furthermore, it describes the typical differences in the activation of individual brain regions between schizophrenic patients and healthy control persons. This information should be helpful in identifying the deficit profile of each patient and create an individual therapy plan. (orig.) [German] Kognitive Defizite sind ein zentraler Bestandteil der Symptomatik schizophrener Patienten. Diese Defizite betreffen v. a. die Aufmerksamkeit, exekutive Funktionen sowie das Gedaechtnis. Der vorliegende Beitrag zeigt den Stellenwert der funktionellen Magnetresonanztomographie (fMRT) in Hinblick auf Diagnostik und Therapiemonitoring der unterschiedlichen kognitiven Teilbereiche auf. Darueber hinaus werden die Unterschiede in Bezug auf die Aktivierung der einzelnen Gehirnareale zwischen schizophrenen Patienten und gesunden Kontrollpersonen dargestellt. Diese Informationen sollen helfen, in der Praxis ein Profil der kognitiven Leistungsreduktionen sowie ein darauf angepasstes Therapiekonzept zu erstellen. (orig.)

  4. Glucosylsphingosine is a highly sensitive and specific biomarker for primary diagnostic and follow-up monitoring in Gaucher disease in a non-Jewish, Caucasian cohort of Gaucher disease patients.

    Science.gov (United States)

    Rolfs, Arndt; Giese, Anne-Katrin; Grittner, Ulrike; Mascher, Daniel; Elstein, Deborah; Zimran, Ari; Böttcher, Tobias; Lukas, Jan; Hübner, Rayk; Gölnitz, Uta; Röhle, Anja; Dudesek, Ales; Meyer, Wolfgang; Wittstock, Matthias; Mascher, Hermann

    2013-01-01

    Gaucher disease (GD) is the most common lysosomal storage disorder (LSD). Based on a deficient β-glucocerebrosidase it leads to an accumulation of glucosylceramide. Standard diagnostic procedures include measurement of enzyme activity, genetic testing as well as analysis of chitotriosidase and CCL18/PARC as biomarkers. Even though chitotriosidase is the most well-established biomarker in GD, it is not specific for GD. Furthermore, it may be false negative in a significant percentage of GD patients due to mutation. Additionally, chitotriosidase reflects the changes in the course of the disease belatedly. This further enhances the need for a reliable biomarker, especially for the monitoring of the disease and the impact of potential treatments. Here, we evaluated the sensitivity and specificity of the previously reported biomarker Glucosylsphingosine with regard to different control groups (healthy control vs. GD carriers vs. other LSDs). Only GD patients displayed elevated levels of Glucosylsphingosine higher than 12 ng/ml whereas the comparison controls groups revealed concentrations below the pathological cut-off, verifying the specificity of Glucosylsphingosine as a biomarker for GD. In addition, we evaluated the biomarker before and during enzyme replacement therapy (ERT) in 19 patients, demonstrating a decrease in Glucosylsphingosine over time with the most pronounced reduction within the first 6 months of ERT. Furthermore, our data reveals a correlation between the medical consequence of specific mutations and Glucosylsphingosine. In summary, Glucosylsphingosine is a very promising, reliable and specific biomarker for GD.

  5. NIO1 diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Zaniol, B., E-mail: zaniol@igi.cnr.it; Barbisan, M.; Pasqualotto, R.; Serianni, G. [Consorzio RFX, Corso Stati Uniti 4, I-35127 Padova (Italy); Cavenago, M. [INFN-LNL, v.le dell' Università 2, I-35020, Legnaro (PD) Italy (Italy); De Muri, M. [Consorzio RFX, Corso Stati Uniti 4, I-35127 Padova (Italy); INFN-LNL, v.le dell' Università 2, I-35020, Legnaro (PD) Italy (Italy); Mimo, A. [Università degli Studi di Padova, Via 8 Febbraio 2, I-35122 Padova (Italy)

    2015-04-08

    The radio frequency ion source NIO1, jointly developed by Consorzio RFX and INFN-LNL, will generate a 60kV-135mA hydrogen negative ion beam, composed of 9 beamlets over an area of about 40 × 40 mm{sup 2}. This experiment will operate in continuous mode and in conditions similar to those foreseen for the larger ion sources of the Neutral Beam Injectors for ITER. The modular design of NIO1 is convenient to address the several still open important issues related to beam extraction, optics, and performance optimization. To this purpose a set of diagnostics is being implemented. Electric and water cooling plant related measurements will allow monitoring current, pressure, flow, and temperature. The plasma in the source will be characterized by emission spectroscopy, cavity ring-down and laser absorption spectroscopy. The accelerated beam will be analyzed with a fast emittance scanner, its intensity profile and divergence with beam emission spectroscopy and visible tomography. The power distribution of the beam on the calorimeter will be monitored by thermocouples and by an infrared camera. This contribution presents the implementation and initial operation of some of these diagnostics in the commissioning phase of the experiment, in particular the cooling water calorimetry and emission spectroscopy.

  6. Vibrotactile and Vibroacoustic Communications

    DEFF Research Database (Denmark)

    Morrison, Ann; Manresa, Cristina; Knoche, Hendrik Ole

    2017-01-01

    period. Participants wearing the vest (and their pair) completed a set of tasks. We logged use and responses, recorded all activities on video, and conducted post-experiment interviews and questionnaires. Results: The results depicted the participants’ experience, communication and connection while...

  7. Glaucoma diagnostics.

    Science.gov (United States)

    Geimer, Sabina Andersson

    2013-02-01

    This thesis addresses several aspects of glaucoma diagnostics from both a clinical and a screening perspective. New instruments for diagnosing glaucoma have been developed over the past years, but little information is available regarding their performance as screening methods and their usefulness in ordinary clinical practice. PURPOSE OF THE RESEARCH UNDERLYING THIS THESIS:  The objectives of this research were as follows: to compare the accuracy of results of analysis of the optic nerve head (ONH) achieved by computerized imaging using the Heidelberg Retina Tomograph (HRT) and by subjective assessment performed by physicians with different degrees of experience of glaucoma (paper III); to evaluate the effect of a continuous medical education (CME) lecture on subjective assessment of the ONH for diagnosis of glaucoma (paper II); to investigate subjective assessment of perimetric test results by physicians with varying knowledge of glaucoma with a trained artificial neural network (ANN) and to compare the certainty of the classifications (paper IV); and to compare the diagnostic performance of time-domain Stratus optical coherence tomography (OCT) with that of spectral-domain Cirrus OCT (paper I), frequency doubling technology (FDT) screening perimetry and scanning laser polarimetry with the GDx variable corneal compensator (VCC) in a random population-based sample and in patients with glaucoma of varying disease severity.   In evaluation of the ONH, use of the HRT statistical tools, Moorfields regression analysis (MRA) and the Glaucoma Probability Score (GPS) was compared with subjective assessment performed by 45 physicians. Optic nerve head images and photographs from 138 healthy and 97 glaucoma subjects were included. The sensitivity of MRA was higher (87-94%) than that of the average physician (62-82%), considerably greater than that of ophthalmologists with subspecialties other than glaucoma (53-77%) and non-significantly better than that of glaucoma

  8. Neuroimaging diagnostic and monitoring approaches in ophthalmology.

    Science.gov (United States)

    Chwalisz, Bart K; Bouffard, Marc A; Prasad, Sashank; Cestari, Dean M

    2018-02-01

    We review new applications of optical coherence tomography (OCT) technology in neuro-ophthalmology. We also describe new technologies for visualizing the extracranial vessels in the diagnosis of giant cell arteritis (GCA). Newer OCT modalities are expanding the evaluation of the optic disc, and are being applied to a number of neurologic conditions such as demyelinating and neurodegenerative disease. Swept-source OCT and enhanced-depth imaging OCT are refining the fine-grained analysis of the optic nerve head in the diagnosis of papilledema and optic nerve drusen. OCT-angiography is opening up new avenues to the study of the vasculature of the optic nerve head and its disorders, including ischemic optic neuropathy. Newer technologies in the diagnosis of GCA include vascular ultrasound, magnetic resonance imaging (MRI) of the extracranial vasculature and PET imaging of the large vessels. OCT and several of its derivations are advancing diagnosis, and in some cases prognostication, in a variety of inflammatory, ischemic and compressive optic neuropathies. These technologies hold potential in the laboratory as well, yielding insights into the mechanisms of a variety of neurological conditions. In addition, further developments in MRI and ultrasonography techniques are shaping the approach to the diagnosis of GCA.

  9. Diagnostic thoracoscopy

    Directory of Open Access Journals (Sweden)

    Plavec Goran

    2002-01-01

    Full Text Available Diagnostic thoracoscopy in patients with pleural effusion of unclear origin mostly provides the correct diagnosis. Results from published reports of previous researches are not uniform. In 47 male and 20 female patients with pleural effusion of unknown etiology, after receiving negative results obtained from cytological finding of pleural effusion and percutaneous needle biopsy, thoracoscopy with biopsy of one or both pleurae was performed. Procedure was done in local anesthesia using Stortz rigid thoracoscope. In 37 patients with malignant disease (primary or metastatic diagnosis was confirmed histopathologically in 31 patient (81.12%. In 27 patients with inflammatory pleural disease diagnosis was confirmed histopathologically in 22 patients (81.4%. Among 11 patients with specific pleural effusions, tuberculosis was confirmed in 10 (90.91%. Normal finding in cases of spontaneous pneumothorax and pulmonary embolism was taken as a positive result. Total number of positive findings was 55 (82.10%. In one patient, the third spontaneous pneumothorax was the indication for thoracoscopy, and after numerous bullae were seen during the procedure, talcum powder pleurodesis was done. In four patients low intensity subcutaneous emphysema occurred one day after thoracoscopy. It can be concluded that thoracoscopy in local anesthesia out of the operating room is good and practical method for solving the unclear pleural effusions, with neglectable rate of complications.

  10. Diagnostic imaging of the prostate

    Energy Technology Data Exchange (ETDEWEB)

    Watanabe, Hiroki (Kyoto Prefectural Univ. of Medicine (Japan))

    1991-01-01

    Modalities for the diagnostic imaging of the prostate are surveyed. Transrectal sonography is thought to be the best method for the purpose, because of its non-invasive nature, fine picture quality, sufficient reproductivity and less expensive cost. Up-to-date utilizations of the method are described, such as diagnostic capability, staging, monitoring, screening and intervention. CT is less effective but MRI is promising to visualize internal structure inside the prostate. Two very new techniques, namely, ultrasonic Doppler color flow mapping and positron emission CT (PET), of which application to the prostate is being investigated originally in our laboratory, are introduced. (author) 100 refs.

  11. [The diagnostic possibilities of saliva].

    Science.gov (United States)

    Kochurova, E V; Kozlov, S V

    2014-01-01

    Saliva is a clinically informative biological fluid which contains multitude of bio-markers. This characteristic makes it possible to carry out numerous analyzes for developing mode to test patient in situ, express-tests included. The diagnostic by saliva is a new area of more simple application both markers and analyzers that can be useful in diagnostic of diseases of oral cavity, oncological diseases included. The using of saliva expands perspectives for making clinical diagnosis and establishment of dynamics and monitoring of disease.

  12. Beam diagnostics

    CERN Document Server

    Raich, U

    2008-01-01

    Most beam measurements are based on the electro-magnetic interaction of fields induced by the beam with their environment. Beam current transformers as well as beam position monitors are based on this principle. The signals induced in the sensors must be amplified and shaped before they are converted into numerical values. These values are further treated numerically in order to extract meaningful machine parameter measurements. The lecture introduces the architecture of an instrument and shows where in the treatment chain digital signal analysis can be introduced. Then the use of digital signal processing is presented using tune measurements, orbit and trajectory measurements as well as beam loss detection and longitudinal phase space tomography as examples. The hardware as well as the treatment algorithms and their implementation on Digital Signal Processors (DSPs) or in Field Programmable Gate Arrays (FPGAs) are presented.

  13. A self diagnostic system for piezoelectric sensors

    Science.gov (United States)

    Atherton, William J.; Flanagan, Patrick M.

    1989-01-01

    A technique for determining the mounting conditions of a piezoelectric accelerometer is presented. This technique electrically stimulates the piezoelectric element in the 'diagnostic' frequency band measuring the electrical frequency response characteristics across a capacitive load impedance. The diagnostic frequency band is tipically much higher than the operating bandwidth of the accelerometer. The resonant frequencies of the accelerometer are included in the diagnostic band. By monitoring the shift in these resonant frequencies, via electrical stimulation techniques, certain diagnostic conditions including mounting conditions can be determined. Experimental data from a compression mode accelerometer is used to demonstrate this technique.

  14. Accelerator Technology: Beam Instrumentation and Diagnostics

    CERN Document Server

    Jones, R; Schmickler, H

    2013-01-01

    This document is part of Subvolume C 'Accelerators and Colliders' of Volume 21 'Elementary Particles' of Landolt-Börnstein - Group I 'Elementary Particles, Nuclei and Atoms'. It contains the the Section '8.6 Beam Instrumentation and Diagnostics' of the Chapter '8 Accelerator Technology' with the content: 8.6 Beam Instrumentation and Diagnostics 8.6.1 Beam Position Measurement 8.6.2 Beam Current and Intensity Measurement 8.6.3 Diagnostics of Transverse Beam Motion 8.6.4 Beam Profile Measurements 8.6.5 Beam Loss Monitoring 8.6.6 Short Bunch Length Diagnostics

  15. Methods and equipment for diagnosis of components of Novovoronezh nuclear power plant

    Energy Technology Data Exchange (ETDEWEB)

    Prokop, K. (Energoinvest, Dukovany (Czechoslovakia). Zavod Jaderna Elektrarna)

    1981-12-01

    The results are reported obtained in applying diagnostic techniques adn diagnostic equipment in the Novovoronezh nuclear power plant. Vibroacoustic, neutron and hydrodynamic noiose of the installation was monitored. The test level method and the mean value comparison method were used for assessing the installation condition. Dispersion analysis methods are used for predicting the propagation of anomalies while for determining specific defects leading to the formation of anomalies the method is used based on the correlation analysis of vibroacoustic signals and other technological noise. The flow charts and descriptions are given of the systems of acoustic emission testing, reactor internals testing using neutron noise, pump testing, and the spectral analyzer.

  16. What Is Diagnostic Testing?

    Science.gov (United States)

    ... you want to learn. Search form Search Diagnostic testing You are here Home Testing & Services Testing for ... help you make the decision. What Is Diagnostic Testing? Diagnostic genetic testing can usually work out if ...

  17. Oral vs. salivary diagnostics

    Science.gov (United States)

    Marques, Joana; Corby, Patricia M.; Barber, Cheryl A.; Abrams, William R.; Malamud, Daniel

    2015-05-01

    The field of "salivary diagnostics" includes studies utilizing samples obtained from a variety of sources within the oral cavity. These samples include; whole unstimulated saliva, stimulated whole saliva, duct saliva collected directly from the parotid, submandibular/sublingual glands or minor salivary glands, swabs of the buccal mucosa, tongue or tonsils, and gingival crevicular fluid. Many publications state "we collected saliva from subjects" without fully describing the process or source of the oral fluid. Factors that need to be documented in any study include the time of day of the collection, the method used to stimulate and collect the fluid, and how much fluid is being collected and for how long. The handling of the oral fluid during and post-collection is also critical and may include addition of protease or nuclease inhibitors, centrifugation, and cold or frozen storage prior to assay. In an effort to create a standard protocol for determining a biomarker's origin we carried out a pilot study collecting oral fluid from 5 different sites in the mouth and monitoring the concentrations of pro- and anti-inflammatory cytokines detected using MesoScaleDiscovery (MSD) electrochemiluminesence assays. Our data suggested that 3 of the cytokines are primarily derived from the submandibular gland, while 7 of the cytokines come from a source other than the major salivary glands such as the minor salivary glands or cells in the oral mucosae. Here we review the literature on monitoring biomarkers in oral samples and stress the need for determining the blood/saliva ratio when a quantitative determination is needed and suggest that the term oral diagnostic be used if the source of an analyte in the oral cavity is unknown.

  18. Saliva as a diagnostic medium.

    Science.gov (United States)

    Pink, Richard; Simek, Jiri; Vondrakova, Jana; Faber, Edgar; Michl, Petr; Pazdera, Jindrich; Indrak, Karel

    2009-06-01

    This is a review of current knowledge on the use of saliva, gingival cervical fluid and mucosal transudate in the detection of some oral and systemic diseases as well as drugs. Oral fluid is a diagnostic medium that can be easily collected and with minimal invasion but it has been neglected in the past. Today, saliva is being used more often to diagnose: HIV virus, oro-facial and systemic tumors, cardiovascular disease and in detecting addictive substances. Neutropil levels in saliva may also indicate successful bone marrow transplant. Oral fluid is now systematically being researched and oral fluid analysis is being compared with the analysis of other diagnostic media such as blood and urine. A number of recent studies have focused on oncogenic marker detection and its monitoring in saliva. The latest clinical and laboratory findings on diagnostic markers of oropharyngeal carcinoma in oral fluid could be the beginning of their wider use as a diagnostic medium. Oral fluid can also be also used to diagnose other malignancies such as breast cancer which was one of the first malignant tumors to be detected using genetic protein biomarkers. Raised levels of CA15-3 and the epidermal growth factor (EGF) receptor have been found in patients with breast cancer and elevated levels of CA 125 and the glycoprotein complex in the saliva of ovarian cancer patients. Doubtless, the diagnostic value of saliva, aided by current technological development will increase rapidly in the near future.

  19. The diagnostics subsystem on board LISA Pathfinder and LISA

    Energy Technology Data Exchange (ETDEWEB)

    Canizares, P; Conchillo, A; Gesa, L; Lloro, I; Lobo, A; Mateos, I; Sanjuan, J; Sopuerta, C F [Institut de Ciencies de l' Espai, CSIC, Facultat de Ciencies, Torre C5 parell, 08193 Bellaterra (Spain); GarcIa-Berro, E [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Grimani, C [Universita degli Studi di Urbino, and INFN Florence, Istituto di Fisica, Via Santa Chiara 27, 61029 Urbino (Italy); Nofrarias, M [Max-Planck-Institut fuer Gravitationsphysik (Albert-Einstein-Institut), Callinstrasse 38, D-30167 Hannover (Germany); Ramos-Castro, J, E-mail: lobo@ieec.fcr.e [Departament d' Enginyeria Electronica, UPC, Campus Nord, Edifici C4, Jordi Girona 1-3, 08034 Barcelona (Spain)

    2009-05-07

    The data and diagnostics subsystem of the LTP hardware and software are at present essentially ready for delivery. In this presentation we intend to describe the scientific and technical aspects of this subsystem, which includes thermal diagnostics, magnetic diagnostics and a radiation monitor, as well as the prospects for their integration within the rest of the LTP. We will also sketch a few lines of progress recently open towards the more demanding diagnostics requirements which will be needed for LISA.

  20. Fuel-motion diagnostics and cineradiography

    Energy Technology Data Exchange (ETDEWEB)

    DeVolpi, A.

    1982-09-01

    Nuclear and non-nuclear applications of cineradiography are reviewed, with emphasis on diagnostic instrumentation for in-pile transient-reactor safety testing of nuclear fuel motion. The primary instrument for this purpose has been the fast-neutron hodoscope, which has achieved quantitative monitoring of time, location, mass, and velocity of fuel movement under the difficult conditions associated with transient-reactor experiments. Alternative diagnostic devices that have been developed have not matched the capabilities of the hodoscope. Other applications for the fuel-motion diagnostic apparatus are also evolving, including time-integrated radiography and direct time- and space-resolved fuel-pin power monitoring. Although only two reactors are now actively equipped with high-resolution fuel-motion diagnostic systems, studies and tests have been carried out in and for many other reactors.

  1. O vídeo-EEG dia no diagnóstico de eventos paroxísticos na infância The diagnostic value of short-term video-EEG monitoring in childhood

    Directory of Open Access Journals (Sweden)

    Alessandra Freitas

    2003-06-01

    and limitations of this procedure. PATIENTS AND METHODS: a prospective protocol, developed in the University of São Paulo, analyzed 38 consecutive patients (age ranging from 4 months to 17 years; mean 6.9 years. All patients were referred in order to establish the diagnosis. The patients were divided in the following groups according to the main clinical complaint: doubts about seizure/syndromic classification (Group I, n = 22; differential diagnosis with non-epileptic events (Group II, n = 8 and differential diagnosis between cognitive decline and status epilepticus (Group III, n = 8. RESULTS: clinical episodes were observed in 36 patients (94.7%. In group I, seizures were reclassified in 11/22 (50% patients and confirmed in eight (36.4%. One patient presented a sleep disorder and two did not present clinical events during monitoring. Syndromic classification was modified in nine (40.9%. In group II, four patients (50% presented epileptic seizures; two had movement disorders and two, non-epileptic events. The cognitive deterioration was correlated with non-convulsive status epilepticus in five children (62.5% of group III. Alterations of therapeutic and/or diagnostic approaches, as a consequence of monitoring, were performed in 21/38 (55.3% patients. CONCLUSION: in our series, short-term video-EEG monitoring established a reliable diagnosis in most patients due to correlation between clinical and EEG data. This procedure was well tolerated by children, including infants and those with psychiatric disorders.

  2. Thread as a substrate for microfluidic diagnostics

    OpenAIRE

    Ballerini, David Robert

    2017-01-01

    Strong need exists in the developing world for affordable diagnostics for health care and environmental monitoring. Diagnostic devices must meet a number of criteria to be suitable for these roles, including being cheap, easily used and transported, but also rapid and accurate, without the need for external equipment. The literature is crowded with studies which employed paper as a substrate for meeting this end, but a recently blossoming field of study has turned to the common ...

  3. Prediction of the vibroacoustic behavior of a submerged shell with non-axisymmetric internal substructures by a condensed transfer function method

    Science.gov (United States)

    Meyer, V.; Maxit, L.; Guyader, J.-L.; Leissing, T.

    2016-01-01

    The vibroacoustic behavior of axisymmetric stiffened shells immersed in water has been intensively studied in the past. On the contrary, little attention has been paid to the modeling of these shells coupled to non-axisymmetric internal frames. Indeed, breaking the axisymmetry couples the circumferential orders of the Fourier series and considerably increases the computational costs. In order to tackle this issue, we propose a sub-structuring approach called the Condensed Transfer Function (CTF) method that will allow assembling a model of axisymmetric stiffened shell with models of non-axisymmetric internal frames. The CTF method is developed in the general case of mechanical subsystems coupled along curves. A set of orthonormal functions called condensation functions, which depend on the curvilinear abscissa along the coupling line, is considered. This set is then used as a basis for approximating and decomposing the displacements and the applied forces at the line junctions. Thanks to the definition and calculation of condensed transfer functions for each uncoupled subsystem and by using the superposition principle for passive linear systems, the behavior of the coupled subsystems can be deduced. A plane plate is considered as a test case to study the convergence of the method with respect to the type and the number of condensation functions taken into account. The CTF method is then applied to couple a submerged non-periodically stiffened shell described using the Circumferential Admittance Approach (CAA) with internal substructures described by Finite Element Method (FEM). The influence of non-axisymmetric internal substructures can finally be studied and it is shown that it tends to increase the radiation efficiency of the shell and can modify the vibrational and acoustic energy distribution.

  4. Vibro-acoustic modeling and analysis of a coupled acoustic system comprising a partially opened cavity coupled with a flexible plate

    Science.gov (United States)

    Shi, Shuangxia; Su, Zhu; Jin, Guoyong; Liu, Zhigang

    2018-01-01

    This paper is concerned with the modeling and solution method of a three-dimensional (3D) coupled acoustic system comprising a partially opened cavity coupled with a flexible plate and an exterior field of semi-infinite size, which is ubiquitously encountered in architectural acoustics and is a reasonable representation of many engineering occasions. A general solution method is presented to predict the dynamic behaviors of the three-dimensional (3D) acoustic coupled system, in which the displacement of the plate and the sound pressure in the cavity are respectively constructed in the form of the two-dimensional and three-dimensional modified Fourier series with several auxiliary functions introduced to ensure the uniform convergence of the solution over the entire solution domain. The effect of the opening is taken into account via the work done by the sound pressure acting at the coupling aperture that is contributed from the vibration of particles on the acoustic coupling interface and on the structural-acoustic coupling interface. Both the acoustic coupling between finite cavity and exterior field and the structural-acoustic coupling between flexible plate and interior acoustic field are considered in the vibro-acoustic modeling of the three-dimensional acoustic coupled acoustic system. The dynamic responses of the coupled structural-acoustic system are obtained using the Rayleigh-Ritz procedure based on the energy expressions for the coupled system. The accuracy and effectiveness of the proposed method are validated through numerical examples and comparison with results obtained by the boundary element analysis. Furthermore, the influence of the opening and the cavity volume on the acoustic behaviors of opened cavity system is studied.

  5. Positive Emotional Experience: Induced by Vibroacoustic Stimulation Using a Body Monochord in Patients with Psychosomatic Disorders: Is Associated with an Increase in EEG-Theta and a Decrease in EEG-Alpha Power.

    Science.gov (United States)

    Sandler, H; Tamm, S; Fendel, U; Rose, M; Klapp, B F; Bösel, R

    2016-07-01

    Relaxation and meditation techniques are generally characterized by focusing attention, which is associated with an increase of frontal EEG Theta. Some studies on music perception suggest an activation of Frontal Midline Theta during emotionally positive attribution, others display a lateralization of electrocortical processes in the attribution of music induced emotion of different valence. The present study examined the effects of vibroacoustic stimulation using a Body Monochord and the conventional relaxation music from an audio CD on the spontaneous EEG of patients suffering from psychosomatic disorders (N = 60). Each treatment took about 20 min and was presented to the patients in random order. Subjective experience was recorded via self-rating scale. EEG power spectra of the Theta, Alpha-1 and Alpha-2 bands were analysed and compard between the two treatment conditions. There was no lateralization of electrocortical activity in terms of the emotional experience of the musical pieces. A reduction in Alpha-2 power occurred during both treatments. An emotionally positive attribution of the experience of the vibroacoustically induced relaxation state is characterized by a more pronounced release of control. In the context of focused attention this is interpreted as flow experience. The spontaneous EEG showed an increase in Theta power, particularly in the frontal medial and central medial area, and a greater reduction in Alpha-2 power. The intensity of positive emotional feelings during the CD music showed no significant effect on the increase in Theta power.

  6. 21 CFR 882.1610 - Alpha monitor.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Alpha monitor. 882.1610 Section 882.1610 Food and... NEUROLOGICAL DEVICES Neurological Diagnostic Devices § 882.1610 Alpha monitor. (a) Identification. An alpha monitor is a device with electrodes that are placed on a patient's scalp to monitor that portion of the...

  7. Saliva as a diagnostic fluid.

    Science.gov (United States)

    Samaranayake, Lakshman

    2007-10-01

    The use of saliva as a diagnostic fluid for various human ailments is gaining popularity as it offers distinct advantages over serum. These include the non-invasive nature of saliva collection compared with phlebotomy, simplicity of collection even for individuals with a modest training and the cost-effective applicability for screening large populations. Whole saliva is most frequently used for diagnosis of systemic diseases since it is readily collected and contains serum constituents while gland-specific saliva is useful for investigating pathology of major salivary glands. Broadly, saliva analysis is currently used for the diagnosis of infectious and malignant diseases, hereditary disorders, autoimmune diseases, and endocrine disorders, as well as for the assessment of therapeutic drug levels, particularly in monitoring drug abuse. This review addresses the current status of salivary diagnostics and their future potential.

  8. Prenatal Genetic Diagnostic Tests

    Science.gov (United States)

    ... Education & Events Advocacy For Patients About ACOG Prenatal Genetic Diagnostic Tests Home For Patients Search FAQs Prenatal ... Pamphlets - Spanish FAQ164, September 2016 PDF Format Prenatal Genetic Diagnostic Tests Pregnancy What is prenatal genetic testing? ...

  9. Thioaptamer Diagnostic System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — AM Biotechnologies (AM) will develop a diagnostic system in response to SBIR Topic X10.01 Reusable Diagnostic Lab Technology that will simultaneously detect and...

  10. Diagnostic Algorithm Benchmarking

    Science.gov (United States)

    Poll, Scott

    2011-01-01

    A poster for the NASA Aviation Safety Program Annual Technical Meeting. It describes empirical benchmarking on diagnostic algorithms using data from the ADAPT Electrical Power System testbed and a diagnostic software framework.

  11. INTEGRATED DIAGNOSTIC TECHNIQUE FOR NUCLEAR POWER PLANTS

    Directory of Open Access Journals (Sweden)

    AKIO GOFUKU

    2014-12-01

    Full Text Available It is very important to detect and identify small anomalies and component failures for the safe operation of complex and large-scale artifacts such as nuclear power plants. Each diagnostic technique has its own advantages and limitations. These facts inspire us not only to enhance the capability of diagnostic techniques but also to integrate the results of diagnostic subsystems in order to obtain more accurate diagnostic results. The article describes the outline of four diagnostic techniques developed for the condition monitoring of the fast breeder reactor “Monju”. The techniques are (1 estimation technique of important state variables based on a physical model of the component, (2 a state identification technique by non-linear discrimination function applying SVM (Support Vector Machine, (3 a diagnostic technique applying WT (Wavelet Transformation to detect changes in the characteristics of measurement signals, and (4 a state identification technique effectively using past cases. In addition, a hybrid diagnostic system in which a final diagnostic result is given by integrating the results from subsystems is introduced, where two sets of values called confidence values and trust values are used. A technique to determine the trust value is investigated under the condition that the confidence value is determined by each subsystem.

  12. Molecular diagnostics in genodermatoses.

    Science.gov (United States)

    Schaffer, Julie V

    2012-12-01

    In recent years, there has been tremendous progress in elucidating the molecular bases of genodermatoses. The interface between genetics and dermatology has broadened with the identification of "new" heritable disorders, improved recognition of phenotypic spectrums, and integration of molecular and clinical data to simplify disease categorization and highlight relationships between conditions. With the advent of next-generation sequencing and other technological advances, dermatologists have promising new tools for diagnosis of genodermatoses. This article first addresses phenotypic characterization and classification with the use of online databases, considering concepts of clinical and genetic heterogeneity. Indications for genetic testing related to medical care and patient/family decision making are discussed. Standard genetic testing is reviewed, including resources for finding specialized laboratories, methods of gene analysis, and patient/family counseling. The benefits and challenges associated with multigene panels, array-based analysis (eg, copy number variation, linkage, and homozygosity), and whole-exome or whole-genome sequencing are then examined. Specific issues relating to molecular analysis of mosaic skin conditions and prenatal/preimplantation diagnosis are also presented. Use of the modern molecular diagnostics described herein enhance our ability to counsel, monitor, and treat patients and families affected by genodermatoses, with broader benefits of providing insights into cutaneous physiology and multifactorial skin disorders. Copyright © 2012 Frontline Medical Communications. Published by Elsevier Inc. All rights reserved.

  13. Can monitoring of intrathoracic impedance reduce morbidity and mortality in patients with chronic heart failure? Rationale and design of the Diagnostic Outcome Trial in Heart Failure (DOT-HF)

    NARCIS (Netherlands)

    Braunschweig, Frieder; Ford, Ian; Conraads, Viviane; Cowie, Martin R.; Jondeau, Guillaume; Kautzner, Josef; Lunati, Maurizio; Aguilera, Roberto Munoz; Yu, Cheuk Man; Marijianowskii, Monique; Borggrefe, Martin; van Veldhuisen, Dirk J.

    Background: Chronic heart failure is associated with frequent hospitalisations which are often due to volume-overload decompensation. Monitoring of intrathoracic impedance, measured from an implanted device, can detect increases in pulmonary fluid retention early and facilitate timely treatment

  14. Predicting the conditions under which vibroacoustic resonances with external periodic loads occur in the primary coolant circuits of VVER-based NPPs

    Science.gov (United States)

    Proskuryakov, K. N.; Fedorov, A. I.; Zaporozhets, M. V.

    2015-08-01

    The accident at the Japanese Fukushima Daiichi nuclear power plant (NPP) caused by an earthquake showed the need of taking further efforts aimed at improving the design and engineering solutions for ensuring seismic resistance of NPPs with due regard to mutual influence of the dynamic processes occurring in the NPP building structures and process systems. Resonance interaction between the vibrations of NPP equipment and coolant pressure pulsations leads to an abnormal growth of dynamic stresses in structural materials, accelerated exhaustion of equipment service life, and increased number of sudden equipment failures. The article presents the results from a combined calculation-theoretical and experimental substantiation of mutual amplification of two kinds of external periodic loads caused by rotation of the reactor coolant pump (RCP) rotor and an earthquake. The data of vibration measurements at an NPP are presented, which confirm the predicted multiple amplification of vibrations in the steam generator and RCP at a certain combination of coolant thermal-hydraulic parameters. It is shown that the vibration frequencies of the main equipment may fall in the frequency band corresponding to the maximal values in the envelope response spectra constructed on the basis of floor accelerograms. The article presents the results from prediction of conditions under which vibroacoustic resonances with external periodic loads take place, which confirm the occurrence of additional earthquake-induced multiple growth of pressure pulsation intensity in the steam generator at the 8.3 Hz frequency and additional multiple growth of vibrations of the RCP and the steam generator cold header at the 16.6 Hz frequency. It is shown that at the elastic wave frequency equal to 8.3 Hz in the coolant, resonance occurs with the frequency of forced vibrations caused by the rotation of the RCP rotor. A conclusion is drawn about the possibility of exceeding the design level of equipment vibrations

  15. [Rapid diagnostic test for malaria].

    Science.gov (United States)

    Houzé, S

    2017-02-01

    The rapid diagnostic tests (RDTs) whose main interest lies in their implementation without special equipment by unskilled personnel have grown significantly over the past fifteen years to diagnose malaria. They rely on the detection of specific Plasmodium proteins, PfHRP2, pLDH and aldolase. If the detection of PfHRP2 has very good sensitivity for the diagnosis of Plasmodium falciparum malaria, the detection of pLDH or aldolase is less efficient for other species, leaving its place to the reference microscopic diagnosis. RDT could not generally be used to monitor therapeutic efficacy because they can remain positive after clinical and parasitological cure. Furthermore, the development of the use of these tests has highlighted the need for quality assurance programs to monitor their production as their use.

  16. Glucosylsphingosine Is a Highly Sensitive and Specific Biomarker for Primary Diagnostic and Follow-Up Monitoring in Gaucher Disease in a Non-Jewish, Caucasian Cohort of Gaucher Disease Patients

    OpenAIRE

    Rolfs, Arndt; Giese, Anne-Katrin; Grittner, Ulrike; Mascher, Daniel; Elstein, Deborah; Zimran, Ari; B?ttcher, Tobias; Lukas, Jan; H?bner, Rayk; G?lnitz, Uta; R?hle, Anja; Dudesek, Ales; Meyer, Wolfgang; Wittstock, Matthias; Mascher, Hermann

    2013-01-01

    Background Gaucher disease (GD) is the most common lysosomal storage disorder (LSD). Based on a deficient ?-glucocerebrosidase it leads to an accumulation of glucosylceramide. Standard diagnostic procedures include measurement of enzyme activity, genetic testing as well as analysis of chitotriosidase and CCL18/PARC as biomarkers. Even though chitotriosidase is the most well-established biomarker in GD, it is not specific for GD. Furthermore, it may be false negative in a significant percentag...

  17. Use of saliva as a diagnostic fluid in dentistry

    National Research Council Canada - National Science Library

    Todorovic, Tatjana; Dozic, Ivan; Pavlica, Dusan; Markovic, Dejan; Ivanovic, Mirjana; Brajovic, Gavrilo; Stefanovic, Gordana; Mirkovic, Silvija; Andjelski, Biljana

    2005-01-01

    .... Over the last few decades, saliva has been evaluated as a diagnostic fluid in medicine for determining systemic disease markers as well as for monitoring numerous drugs, narcotics, and hormones...

  18. Iodo-derivatives of dithizone with potential diagnostic application.

    Science.gov (United States)

    Lukasiewicz, A; Woźniak, I; Fiedor, P; Rowiński, W; Mazurek, A P; Licińska, I

    1994-01-01

    The mono and diiodo-derivatives of dithizone labelled with radioactive 131I isotope were obtained. Those compounds can be used for diagnostic of pancreas and other organs to monitor pathological states.

  19. In-vitro diagnostic devices introduction to current point-of-care diagnostic devices

    CERN Document Server

    Cheng, Chao-Min; Chen, Chien-Fu

    2016-01-01

    Addressing the origin, current status, and future development of point-of-care diagnostics, and serving to integrate knowledge and tools from Analytical Chemistry, Bioengineering, Biomaterials, and Nanotechnology, this book focusses on addressing the collective and combined needs of industry and academia (including medical schools) to effectively conduct interdisciplinary research. In addition to summarizing and detailing developed diagnostic devices, this book will attempt to point out the possible future trends of development for point-of-care diagnostics using both scientifically based research and practical engineering needs with the aim to help novices comprehensively understand the development of point-of-care diagnostics. This includes demonstrating several common but critical principles and mechanisms used in point-of-care diagnostics that address practical needs (e.g., disease or healthcare monitoring) using two well-developed examples so far: 1) blood glucose meters (via electrochemistry); and, 2) p...

  20. Pharmaceutical care and the use of routine diagnostic tools by ...

    African Journals Online (AJOL)

    Purpose: To evaluate the use of routine diagnostic tools among community pharmacists in Ibadan,. Nigeria. Methods: ... measurements in this setting is recommended by ... Development. Majority of respondents used routine diagnostic tools in their pharmacies. These tools included blood pressure monitors (87.6%), glucose.

  1. Electromagnetic-emission diagnostics of dielectric materials under ultrasonic loading

    Science.gov (United States)

    Chakhlov, V. L.; Simanchuk, V. I.; Kargapol'Tsev, A. V.

    1993-08-01

    The electromagnetic-emission diagnostic inspection of solid dielectrics subjected to ultrasonic loading created by a pulsed laser beam of nanosecond duration is investigated experimentally. The experimental apparatus and procedure are described. It is shown that the procedure is an effective diagnostic tool for monitoring the electrical state and structure of solid dielectric materials.

  2. Oxidative decomposition of methanol in a vibroacoustic fluidized bed of Ag-coated cenosphere core-shell catalyst

    Directory of Open Access Journals (Sweden)

    Berkowicz Gabriela

    2016-12-01

    Full Text Available The paper presents results of a study of oxidative decomposition of methanol in a fluidized bed of silver catalyst. The process of methanol oxidation was carried out on Ag-coated cenospheres core-shell catalyst. The catalyst was obtained by precipitation of silver from methanolic solution of silver nitrate on cenospheres. Cenospheres are lightweight, inert, hollow spheres, which can be easily introduced into a fluidized bed. Application of the catalyst in a form of fluidized bed should ensure good temperature equalization which is very important at low temperatures due to the possibility of generation of formaldehyde. It turned out that local hot points occur in that kind of a catalyst (in the form of a fluidized bed but with very low density, thus use of additional acoustic wave is necessary to ensure good control over the temperature of the process. The products of the process of methanol oxidation were monitored on-line by Fourier transform infrared spectroscopy (FTIR. The catalyst has proven to be highly active in the oxidative decomposition of methanol. Full of methanol conversion in reaction of complete oxidation was achieved at 350°C.

  3. A Framework to Debug Diagnostic Matrices

    Science.gov (United States)

    Kodal, Anuradha; Robinson, Peter; Patterson-Hine, Ann

    2013-01-01

    Diagnostics is an important concept in system health and monitoring of space operations. Many of the existing diagnostic algorithms utilize system knowledge in the form of diagnostic matrix (D-matrix, also popularly known as diagnostic dictionary, fault signature matrix or reachability matrix) gleaned from physical models. But, sometimes, this may not be coherent to obtain high diagnostic performance. In such a case, it is important to modify this D-matrix based on knowledge obtained from other sources such as time-series data stream (simulated or maintenance data) within the context of a framework that includes the diagnostic/inference algorithm. A systematic and sequential update procedure, diagnostic modeling evaluator (DME) is proposed to modify D-matrix and wrapper logic considering least expensive solution first. This iterative procedure includes conditions ranging from modifying 0s and 1s in the matrix, or adding/removing the rows (failure sources) columns (tests). We will experiment this framework on datasets from DX challenge 2009.

  4. Diagnostic Measurements for Power Transformers

    Directory of Open Access Journals (Sweden)

    Stefan Tenbohlen

    2016-05-01

    Full Text Available With the increasing age of the primary equipment of the electrical grids there exists also an increasing need to know its internal condition. For this purpose, off- and online diagnostic methods and systems for power transformers have been developed in recent years. Online monitoring is used continuously during operation and offers possibilities to record the relevant stresses which can affect the lifetime. The evaluation of these data offers the possibility of detecting oncoming faults early. In comparison to this, offline methods require disconnecting the transformer from the electrical grid and are used during planned inspections or when the transformer is already failure suspicious. This contribution presents the status and current trends of different diagnostic techniques of power transformers. It provides significant tutorial elements, backed up by case studies, results and some analysis. The broadness and improvements of the presented diagnostic techniques show that the power transformer is not anymore a black box that does not allow a view into its internal condition. Reliable and accurate condition assessment is possible leading to more efficient maintenance strategies.

  5. Modificações da hemodinâmica fetal pelo estímulo sonoro: avaliação pela dopplervelocimetria colorida Vibro-acoustic stimulation induced hemodynamic fetal changes assessed by color doppler

    Directory of Open Access Journals (Sweden)

    Francisco Mauad Filho

    1999-04-01

    Full Text Available Objetivos: verificar se ocorrem ou não alterações hemodinâmicas na aréria cerebral média (ACM aferido pela dopplervelocimetria colorida após realização de um estímulo sonoro. Métodos: trinta fetos de gestantes consideradas clinicamente normais com idade gestacional igual ou superior a 28 semanas foram submetidos a um estímulo sonoro. Examinamos as alterações da velocidade sangüínea na ACM fetal por meio do índice de resistência e da freqüência cardíaca fetal, pelo doppler colorido, antes e depois do estímulo acústico. Resultados: a média da freqüência cardíaca fetal (FCF antes do estímulo sonoro foi de 142,41 batimentos por minuto (bpm com desvio padrão de 9,01 e faixa de variação de 122 a 162 bpm. Após o estímulo sonoro, a média da FCF foi de 159,44 bpm com desvio padrão de 15,49, com faixa de variação de 130 a 187 bpm (pPurpose: to determine the possible occurrence of hemodynamic changes in the middle cerebral artery of the fetus (MCA using color doppler after vibro-acoustic stimulation. Methods: thirty fetuses from pregnant women considered to be clinically normal, with a gestational age of 28 weeks or more were submitted to vibro-acoustic stimulation. We examined the changes in blood flow rate in the middle cerebral artery of the fetus on the basis of resistance index (RI and fetal heart rate (FHR by color doppler before and after the sound stimulus. Results: mean FHR before vibro-acoustic stimulation was 142.41 beats per minute (bpm with a standard deviation of 9.01 and a range of 122 to 162 bpm. After stimulation, mean FHR was 159.44 bpm with a standard deviation of 15.49 and a range of 130 to 187 bpm (p<0.01. Mean RI in the MCA of the fetuses was 75.89% (range: 64 to 91% before the experiment. After the vibro-acoustic stimulation, mean RI was 66.93% (range: 47 to 83%; p < 0.01. Conclusions: we observed that a sound stimulus provokes the well-known immediate and significant elevation of FHR and a

  6. MODERN ASPECTS OF BRIDGES MONITORING

    Directory of Open Access Journals (Sweden)

    M. I. Kazakevych

    2007-12-01

    Full Text Available The major concepts of the elaboration and realization of the bridge construction monitoring systemic approach are presented in this paper. The main peculiarity of the bridge monitoring modern aspect is pointed out here, namely, the transition from the demands of providing the reliability to the demands of providing the whole complex of the structure consumer qualities. The criteria of diagnostics of the bridge exploitation reliability as the fundamental aim of monitoring are formulated here.

  7. Advanced Light Source beam diagnostics systems

    Energy Technology Data Exchange (ETDEWEB)

    Hinkson, J.

    1993-10-01

    The Advanced Light Source (ALS), a third-generation synchrotron light source, has been recently commissioned. Beam diagnostics were very important to the success of the operation. Each diagnostic system is described in this paper along with detailed discussion of its performance. Some of the systems have been in operation for two years. Others, in the storage ring, have not yet been fully commissioned. These systems were, however, working well enough to provide the essential information needed to store beam. The devices described in this paper include wall current monitors, a beam charge monitor, a 50 ohm Faraday cup, DC current transformers, broad-hand striplines, fluorescence screens, beam collimators and scrapers, and beam position monitors. Also, the means by which waveforms are digitized and displayed in the control room is discussed.

  8. Proceedings of the Annual Tri-Service Meeting for Aircraft Engine Monitoring and Diagnostics (7th) Held on 5-7 December 1978, at Arnold Engineering Development Center, Arnold AFS, Tennessee

    Science.gov (United States)

    1979-07-01

    eliminated. Efforts to accomplish air- borne vibration monitoring on the T-38, and to date, the A-1O have not beer successful. Generally, the output data...approximately, if the thrust setting is correct for a given control setting, (3) determine if the fuel comsumption is as it should be for a control setting

  9. Evaluating diagnostic tests

    African Journals Online (AJOL)

    Adele

    Appraising the predictive abilities of diagnostic tests can be surprisingly difficult. The purpose of this article is to provide an introduction to the principles underlying the objective evaluation of diagnostic tests. Starting from basic concepts about probability,. Bayes' theorem will be introduced and an explanation given as to.

  10. A Demonstration of Concrete Structural Health Monitoring Framework for Degradation due to Alkali-Silica Reaction

    Energy Technology Data Exchange (ETDEWEB)

    Mahadevan, Sankaran [Idaho National Lab. (INL), Idaho Falls, ID (United States); Agarwal, Vivek [Idaho National Lab. (INL), Idaho Falls, ID (United States); Neal, Kyle [Idaho National Lab. (INL), Idaho Falls, ID (United States); Nath, Paromita [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bao, Yanqing [Idaho National Lab. (INL), Idaho Falls, ID (United States); Cai, Guowei [Idaho National Lab. (INL), Idaho Falls, ID (United States); Orme, Peter [Idaho National Lab. (INL), Idaho Falls, ID (United States); Adams, Douglas [Idaho National Lab. (INL), Idaho Falls, ID (United States); Kosson, David [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-04-01

    Assessment and management of aging concrete structures in nuclear power plants require a more systematic approach than simple reliance on existing code margins of safety. Structural health monitoring of concrete structures aims to understand the current health condition of a structure based on heterogeneous measurements to produce high-confidence actionable information regarding structural integrity that supports operational and maintenance decisions. This ongoing research project is seeking to develop a probabilistic framework for health diagnosis and prognosis of aging concrete structures in a nuclear power plant that is subjected to physical, chemical, environment, and mechanical degradation. The proposed framework consists of four elements: monitoring, data analytics, uncertainty quantification and prognosis. This report focuses on degradation caused by ASR (alkali-silica reaction). Controlled specimens were prepared to develop accelerated ASR degradation. Different monitoring techniques – thermography, digital image correlation (DIC), mechanical deformation measurements, nonlinear impact resonance acoustic spectroscopy (NIRAS), and vibro-acoustic modulation (VAM) -- were used to detect the damage caused by ASR. Heterogeneous data from the multiple techniques was used for damage diagnosis and prognosis, and quantification of the associated uncertainty using a Bayesian network approach. Additionally, MapReduce technique has been demonstrated with synthetic data. This technique can be used in future to handle large amounts of observation data obtained from the online monitoring of realistic structures.

  11. High power microwave diagnostic for the fusion energy experiment ITER

    DEFF Research Database (Denmark)

    Korsholm, Søren Bang; Leipold, Frank; Goncalves, B.

    2016-01-01

    Microwave diagnostics will play an increasingly important role in burning plasma fusion energy experiments like ITER and beyond. The Collective Thomson Scattering (CTS) diagnostic to be installed at ITER is an example of such a diagnostic with great potential in present and future experiments....... The ITER CTS diagnostic will inject a 1 MW 60 GHz gyrotron beam into the ITER plasma and observe the scattering off fluctuations in the plasma — to monitor the dynamics of the fast ions generated in the fusion reactions....

  12. Status of Beam Diagnostic Systems for the PEFP

    CERN Document Server

    Park Jang Ho; Choi Byung Ho; Ha Hwang Woon; Han, Sang-Hyo; Park, Sung-Ju; Woon Parc, Yong; Yun Huang Jung

    2005-01-01

    A proton linear accelerator is currently the construction at the KAERI (Korea Atomic Research Institute) to the PEFP (Proton Engineering Frontier Project) in Korea. We are accomplished the technique development of beam diagnostic system to be currently the construction. We treat beam diagnostics for the high power proton linear accelerator. Prototype beam position & phase monitor (BPPM) electronics was made and tested successfully in one of the beam diagnostic systems. The beam position monitor pickup electrode is a capacitive type (electrostatic type) which has a button form. Button form electrode, in common use around electron synchrotrons and storage rings, are a variant of the electrode with small button form (e.g., sub mm diameter). However, we are designed button form electrode to measure beam position of proton beam. The BCM (Beam Current Monitor) is developed Tuned CT (Current Transformer) for collaborate with Bergoz Instruments. This paper describes the status of beam diagnostic systems for the P...

  13. Fundamentals of ophthalmic diagnostical methods based on laser light scattering

    Science.gov (United States)

    Tuchin, Valery V.; Maksimova, Irina L.; Kochubey, Vyacheslav I.; Semyonova, Tatjana N.; Tatarintsev, Sergey N.; Babkova, N. L.

    1995-05-01

    The basic principles of light scattering methods which should be very useful for ophthalmic disease diagnostics and monitoring are discussed. As an example a human eye lens tissue was considered. Angular-dependent scattering spectra and scattering matrix elements M12, M33, M34 and M44 are suggested as informative parameters for eye lens aging and cataract monitoring.

  14. National NIF Diagnostic Program Interim Management Plan

    Energy Technology Data Exchange (ETDEWEB)

    Warner, B

    2002-04-25

    , cost, and schedule. The NIF Director controls the NNDP Interim Management Plan. A Draft Program Execution Plan (PEP) for the National NIF Diagnostics Program has been also been prepared (NIF-0072083, Oct 2001, attached as Attachment 1) that describes the NNDP technical, cost, and schedule baselines, the method by which the NNDP will fund and monitor the work to be done by the participating laboratories; the process for controlling changes; and the associated reporting and review process. This plan is expected to be approved by the relevant stakeholders at the appropriate time; however, since October 2001, the NNDP has been operating according to the processes laid out in the draft PEP. Below is a summary of the most important aspects of the NNDP that are being applied during this interim period before approval of the full PEP.

  15. Diagnostics in critical conditions

    Directory of Open Access Journals (Sweden)

    SadchikovD.V.

    2011-09-01

    Full Text Available The purpose of research: improvement of quality of diagnostics at the patients in a critical condition in intensive care unit. Material and methods. In total have analyzed 1957 medical cards of the patients who have died in ICU»s. At the first stage studied the factors influencing on diagnostics of critically ill patients (medical cards of 1557 patients; at the second stage investigated influence of the diagnostic standards in ICU»s practice on improvement of quality of diag- nostics of critically ill patients (400 medical cards of the patients who have died. Entry criterions were standards and algorithm of diagnostics. Techniques of research: average bed-day in groups, first-day lethality, quantity of the carried out laboratory tests and tool methods of research, level of consciousness of the patients (Glasgow come score, severity of disease by ICU»s patients (APACHE II scores. Results. Quality of diagnostics depend on carried out laboratory tests and tool methods of research, level of consciousness of the patients (Glasgow come score, severity of disease by ICU»s patients (APACHE II score. The conclusion. The laboratory tests and tool methods of research conforming to the standards of diagnostics are necessary for improvement of quality of diagnostics, it is necessary to take into account an altered level of consciousness (Glasgow come score and severity of disease by ICU»s patients (APACHE II scores

  16. Cable Diagnostic Focused Initiative

    Energy Technology Data Exchange (ETDEWEB)

    Hartlein, R.A.; Hampton, R.N.

    2010-12-30

    This report summarizes an extensive effort made to understand how to effectively use the various diagnostic technologies to establish the condition of medium voltage underground cable circuits. These circuits make up an extensive portion of the electric delivery infrastructure in the United States. Much of this infrastructure is old and experiencing unacceptable failure rates. By deploying efficient diagnostic testing programs, electric utilities can replace or repair circuits that are about to fail, providing an optimal approach to improving electric system reliability. This is an intrinsically complex topic. Underground cable systems are not homogeneous. Cable circuits often contain multiple branches with different cable designs and a range of insulation materials. In addition, each insulation material ages differently as a function of time, temperature and operating environment. To complicate matters further, there are a wide variety of diagnostic technologies available for assessing the condition of cable circuits with a diversity of claims about the effectiveness of each approach. As a result, the benefits of deploying cable diagnostic testing programs have been difficult to establish, leading many utilities to avoid the their use altogether. This project was designed to help address these issues. The information provided is the result of a collaborative effort between Georgia Tech NEETRAC staff, Georgia Tech academic faculty, electric utility industry participants, as well as cable system diagnostic testing service providers and test equipment providers. Report topics include: •How cable systems age and fail, •The various technologies available for detecting potential failure sites, •The advantages and disadvantages of different diagnostic technologies, •Different approaches for utilities to employ cable system diagnostics. The primary deliverables of this project are this report, a Cable Diagnostic Handbook (a subset of this report) and an online

  17. 40 CFR 85.2231 - On-board diagnostic test equipment requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false On-board diagnostic test equipment... Warranty Short Tests § 85.2231 On-board diagnostic test equipment requirements. (a) The test system... be capable of checking for the monitors supported by the on-board diagnostic system and the...

  18. Trends in Laboratory Diagnostic Methods in Periodontology

    Directory of Open Access Journals (Sweden)

    Beáta Bolerázska

    2016-04-01

    Full Text Available This work presents a summary of current knowledge on the laboratory diagnosis of periodontitis. It focuses on the theoretical foundations and is supplemented with new knowledge. It subsequently describes specifically the laboratory diagnosis methods of periodontitis: the protein expression of inflammation, oral microbiology and molecular diagnostics. Periodontitis is a serious disease worldwide and its confirmed association with systemic diseases means its severity is increasing. Its laboratory diagnosis has the potential to rise to the level of clinical and diagnostic imaging. The transfer of diagnostic methods from laboratory to clinical use is increasingly used in the prevention and monitoring of the exacerbation and treatment of periodontal disease, as well as of its impact on systemic disease.

  19. National Convective Weather Diagnostic

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Current convective hazards identified by the National Convective Weather Detection algorithm. The National Convective Weather Diagnostic (NCWD) is an automatically...

  20. Thioaptamer Diagnostic System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — AM Biotechnologies (AM) in partnership with Sandia National Laboratories will develop a Thioaptamer Diagnostic System (TDS) in response to Topic X10.01 Reusable...

  1. Application of light and ultrasound for medical diagnostics and treatment

    Science.gov (United States)

    Esenaliev, Rinat O.

    2002-07-01

    We develop novel optical and ultrasound techniques for medical noninvasive diagnostics and treatment. In this review, we present our results on the development of: (1) optoacoustic technique for detection of small tumors; (2) optoacoustic monitoring of blood oxygenation; (3) optoacoustic monitoring during thermotherapy; (4) optical coherence tomography for monitoring of blood glucose concentration; and (5) laser- and ultrasound-based anti- cancer drug delivery technique. Motivation, experimental methods, results obtained in vitro and in vivo with the use of these techniques are presented.

  2. Revisiting Tversky's diagnosticity principle

    OpenAIRE

    Evers, Ellen R. K.; Daniel eLakens

    2014-01-01

    Similarity is a fundamental concept in cognition. In 1977 Amos Tversky published a highly influential feature-based model of how people judge the similarity between objects. The model highlights the context-dependence of similarity judgments, and challenged geometric models of similarity. One of the context-dependent effects Tversky describes is the diagnosticity principle. The diagnosticity principle determines which features are used to cluster multiple objects into subgroups. Perceived sim...

  3. Molecular diagnostics of periodontitis

    OpenAIRE

    Izabela Korona-Głowniak; Radosław Siwiec; Marcin Berger; Anna Malm; Jolanta Szymańska

    2017-01-01

    The microorganisms that form dental plaque are the main cause of periodontitis. Their identification and the understanding of the complex relationships and interactions that involve these microorganisms, environmental factors and the host’s health status enable improvement in diagnostics and targeted therapy in patients with periodontitis. To this end, molecular diagnostics techniques (both techniques based on the polymerase chain reaction and those involving nucleic acid analysis via hybridi...

  4. Beam Diagnostics for the J-PARC Main Ring Synchrotron

    CERN Document Server

    Toyama, Takeshi; Hashimoto, Yoshinori; Hayashi, Naoki; Kishiro, Junichi; Lee, Seishu; Miura, Takako; Muto, Suguru; Toyokawa, Ryoji

    2005-01-01

    Beam diagnostics: beam intensity monitors (DCCT, SCT, FCT, WCM), beam position monitors (ESM), beam loss monitors (proportional chamber, air ion chamber), beam profile monitors (secondary electron emission, gas-sheet) have been designed, tested, and will be installed for the Main Ring synchrotron of J-PARC (Japan Proton Accelerator Research Complex). This paper describes the basic design principle and specification of each monitor, with a stress on how to cope with high power beam (average circulation current of ~12 A) and low beam loss operation (less than 1 W/m except a collimator region). Some results of preliminary performance test using present beams and a radiation source will be reported.

  5. Monitoring pigmented skin lesions

    Science.gov (United States)

    Wallace, Vincent P.; Bamber, Jeffery C.; Ott, Robert J.; Crawford, Diane C.; Mortimer, Peter S.

    2002-06-01

    The rising incidence of skin cancer has led to an increase in the number of patients with skin lesions that require diagnosis, mostly using subjective visual examination. Successful treatment depends on early diagnosis. Unfortunately diagnostic accuracy, even by experts, can be as low as 56%; therefore, an accurate, objective diagnostic aid is greatly needed. Reflectance characteristics of pigmented skin lesions were documented to evaluate their diagnostic potential. Reflectance spectra in the wavelength range 320-1100nm were obtained from 260 lesions. Differences between spectra from benign and malignant lesions were utilized by extracting features with the best discriminating power. Discrimination was evaluated using two techniques: multivariate statistical analysis and artificial neural networks, using histology as the standard. Each technique was tested in a blind study and assessed in terms of its ability to diagnose new cases and compared to the clinical diagnosis. The artificial neural network achieved the best diagnostic performance for discriminating between malignant melanoma and benign nevi, having a sensitivity of 100% and a specificity of 65%. Utilization of visible and infrared techniques for monitoring skin lesions has lead to improvements in diagnostic accuracy. We conclude that these techniques are worthy of further development and evaluation in clinical practice as a screening tool.

  6. [Diagnostics in osteology].

    Science.gov (United States)

    Jakob, F; Genest, F; Seefried, L; Tsourdi, E; Lapa, C; Hofbauer, L C

    2016-07-01

    Clinical diagnostics in metabolic bone diseases cover a broad spectrum of conventional and state of the art methods ranging from the medical history and clinical examination to molecular imaging. Patient treatment is carried out in an interdisciplinary team due to the multiple interactions of bone with other organ systems. Diagnosis of osteoporosis is supported by high level national guidelines. A paradigm shift concerning the clinical relevance of bone mineral density measurement renders this now to be a strong risk factor rather than a diagnostic parameter, while strengthening the value of other clinical factors for risk assessment. The impact of parameters for muscle mass, structure and function is steadily increasing in all age groups. In order to identify underlying diseases that influence bone metabolism a panel of general laboratory diagnostic parameters is recommended. Markers for bone formation and resorption and specific parameters for the regulation of calcium and phosphate metabolism should be evaluated by specialists because they require diligence in preanalytics and experience in interpretation. Genetic diagnosis is well established for rare bone diseases while diagnostic panels are not yet available for routine diagnostics in polygenetic diseases such as osteoporosis. Conventional radiology is still very important to identify, e. g. fractures, osteolytic and osteoblastic lesions and extraosseous calcifications; however tomography-based methods which combine, e. g. scintigraphy or positron emission technologies with anatomical imaging are of increasing significance. Clinical diagnostics in osteology require profound knowledge and are subject to a dynamic evolution.

  7. Multilayer Thin Film Sensors for Damage Diagnostics

    Science.gov (United States)

    Protasov, A. G.; Gordienko, Y. G.; Zasimchuk, E. E.

    2006-03-01

    The new innovative approach to damage diagnostics within the production and maintenance/servicing procedures in industry is proposed. It is based on the real-time multiscale monitoring of the smart-designed multilayer thin film sensors of fatigue damage with the standard electrical input/output interfaces which can be connected to the embedded and on-board computers. The multilayer thin film sensors supply information about the actual unpredictable deformation damage, actual fatigue life, strain localization places, damage spreading, etc.

  8. Optics/Optical Diagnostics Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — The Optics/Optical Diagnostics Laboratory supports graduate instruction in optics, optical and laser diagnostics and electro-optics. The optics laboratory provides...

  9. Polymer microcantilevers for water quality monitoring

    CSIR Research Space (South Africa)

    Ojijo, Vincent O

    2012-10-01

    Full Text Available The microcantilever project aims to develop novel polymer based microcantilevers able to detect E.coli in water samples for use as a rapid diagnostic for on-site water quality monitoring....

  10. ATV Light MDPS Vibroacoustic Test

    Science.gov (United States)

    Destefanis, S.; Busa, F.; Ullio, R.

    2012-07-01

    Back in late 2010, the ATV (Automated Transfer Vehicle) program opted for the adoption of lighter MDPS (Meteoroid and Debris Protection Shield) panels, to be installed on future ATV units, starting from A TV#3. The rationale behind such decision was to save as much mass as possible, while keeping the MDPS design compliant to its requirements. One of the most critical issues was demonstrating that the installation of thinner MDPS panels (0.0012m thickness instead of 0.0016m) did not induce significant impacts on the currently defined ATV environments. If that had been the case, in fact, the proposed modification to the MDPS panels design might have been rejected, or anyway a costly and long analysis process at system level might have been necessary, to verify all ATV internal equipment environmental compatibility. Such detailed analysis cycle was not compatible with the program tight schedule.

  11. Vibroacoustic characteristics of mine locomotives

    Energy Technology Data Exchange (ETDEWEB)

    Chigirinskii, S.E.; Ponomarev, N.S.; Leiman, Ya.A.

    1982-11-01

    The paper discusses noise pollution caused by locomotives used for mine haulage in underground mining. Noise pollution in a mine working and at the driver working place is measured. Mechanical vibrations of the floor in the driver cab are also determined. Noise pollution and mechanical vibrations of 3 locomotive types are comparatively evaluated: the AM-8D electric locomotive, the GR-4 inertia-type locomotive and the 1D-8 diesel locomotive. The results of investigations are shown in 2 tables. The inertia-type locomotive causes the most intensive noise pollution. Noise pollution of the diesel locomotive has been successfully suppressed by a system of shock absorbers. The following methods for noise and vibration control are discussed: use of soundproof cabs, damping vibrations at the driver's seat, use of motors with noise abatement systems and shock absorbers. (In Russian)

  12. Diagnostic method based on the analysis of vibration and acoustic emission. Monitoring of emergency diesel NPP Garona; Metodo de diagnostico basado en el analisis de vibraciones y emision acustica. Monitorizacion de los diesel de emergencia de CN Garano

    Energy Technology Data Exchange (ETDEWEB)

    Paniagua, L.; Munoz, M.; Moreno, F.; Arroyo, J.; Monne, C.

    2014-04-01

    Maintenance Technicians, more and more, must dispose of predictive tools to diagnose the state of the equipment, especially if they are responsible for the emergency diesel in a Nuclear Power Plant. the use of these tools should be understood as a complement to more classic Preventive Maintenance of the equipment, thus increasing their availability because the parameters necessary for evaluating motor behaviour are taken while the engine is in operation. In this way, it facilitates the decision-making on whether to carry out certain preventive tasks. The basic information about this diagnostic tool presented in this article is based on the reading, recording and analysis of pressure, vibrations and acoustic emission in each engine cylinder during its operating cycle. A nice addition to the above diagnosis is carrying out and endoscopy of each cylinder, which enables the observation of: water leaks, injector leaks, the spraying of each injector, valve leaks,... etc. This article describes the fundamentals of a non-intrusive, easy to use and low cost tool, used to check the function of Emergency Diesel engines, as well as the experience of its use in the St. Maria Garona Nuclear Plant. The article also describes the case of a fault which occurred in the Nuclear Power plant in Garona that would hardly have been possible to detect by other means. This tool was developed jointly by the Engines Laboratory of the Department of Mechanical Engineering at the University of Zaragoza and the St. Maria Garona Nuclear Plant. It has been further improved, extended and optimized over the more than 10 years of its use. (Author)

  13. Anaesthesia monitoring using fuzzy logic.

    Science.gov (United States)

    Baig, Mirza Mansoor; Gholamhosseini, Hamid; Kouzani, Abbas; Harrison, Michael J

    2011-10-01

    Humans have a limited ability to accurately and continuously analyse large amount of data. In recent times, there has been a rapid growth in patient monitoring and medical data analysis using smart monitoring systems. Fuzzy logic-based expert systems, which can mimic human thought processes in complex circumstances, have indicated potential to improve clinicians' performance and accurately execute repetitive tasks to which humans are ill-suited. The main goal of this study is to develop a clinically useful diagnostic alarm system based on fuzzy logic for detecting critical events during anaesthesia administration. The proposed diagnostic alarm system called fuzzy logic monitoring system (FLMS) is presented. New diagnostic rules and membership functions (MFs) are developed. In addition, fuzzy inference system (FIS), adaptive neuro fuzzy inference system (ANFIS), and clustering techniques are explored for developing the FLMS' diagnostic modules. The performance of FLMS which is based on fuzzy logic expert diagnostic systems is validated through a series of off-line tests. The training and testing data set are selected randomly from 30 sets of patients' data. The accuracy of diagnoses generated by the FLMS was validated by comparing the diagnostic information with the one provided by an anaesthetist for each patient. Kappa-analysis was used for measuring the level of agreement between the anaesthetist's and FLMS's diagnoses. When detecting hypovolaemia, a substantial level of agreement was observed between FLMS and the human expert (the anaesthetist) during surgical procedures. The diagnostic alarm system FLMS demonstrated that evidence-based expert diagnostic systems can diagnose hypovolaemia, with a substantial degree of accuracy, in anaesthetized patients and could be useful in delivering decision support to anaesthetists.

  14. Ares I-X Launch Abort System, Crew Module, and Upper Stage Simulator Vibroacoustic Flight Data Evaluation, Comparison to Predictions, and Recommendations for Adjustments to Prediction Methodology and Assumptions

    Science.gov (United States)

    Smith, Andrew; Harrison, Phil

    2010-01-01

    The National Aeronautics and Space Administration (NASA) Constellation Program (CxP) has identified a series of tests to provide insight into the design and development of the Crew Launch Vehicle (CLV) and Crew Exploration Vehicle (CEV). Ares I-X was selected as the first suborbital development flight test to help meet CxP objectives. The Ares I-X flight test vehicle (FTV) is an early operational model of CLV, with specific emphasis on CLV and ground operation characteristics necessary to meet Ares I-X flight test objectives. The in-flight part of the test includes a trajectory to simulate maximum dynamic pressure during flight and perform a stage separation of the Upper Stage Simulator (USS) from the First Stage (FS). The in-flight test also includes recovery of the FS. The random vibration response from the ARES 1-X flight will be reconstructed for a few specific locations that were instrumented with accelerometers. This recorded data will be helpful in validating and refining vibration prediction tools and methodology. Measured vibroacoustic environments associated with lift off and ascent phases of the Ares I-X mission will be compared with pre-flight vibration predictions. The measured flight data was given as time histories which will be converted into power spectral density plots for comparison with the maximum predicted environments. The maximum predicted environments are documented in the Vibroacoustics and Shock Environment Data Book, AI1-SYS-ACOv4.10 Vibration predictions made using statistical energy analysis (SEA) VAOne computer program will also be incorporated in the comparisons. Ascent and lift off measured acoustics will also be compared to predictions to assess whether any discrepancies between the predicted vibration levels and measured vibration levels are attributable to inaccurate acoustic predictions. These comparisons will also be helpful in assessing whether adjustments to prediction methodologies are needed to improve agreement between the

  15. Revisiting Tversky's diagnosticity principle.

    Science.gov (United States)

    Evers, Ellen R K; Lakens, Daniël

    2014-01-01

    Similarity is a fundamental concept in cognition. In 1977, Amos Tversky published a highly influential feature-based model of how people judge the similarity between objects. The model highlights the context-dependence of similarity judgments, and challenged geometric models of similarity. One of the context-dependent effects Tversky describes is the diagnosticity principle. The diagnosticity principle determines which features are used to cluster multiple objects into subgroups. Perceived similarity between items within clusters is expected to increase, while similarity between items in different clusters decreases. Here, we present two pre-registered replications of the studies on the diagnosticity effect reported in Tversky (1977). Additionally, one alternative mechanism that has been proposed to play a role in the original studies, an increase in the choice for distractor items (a substitution effect, see Medin et al., 1995), is examined. Our results replicate those found by Tversky (1977), revealing an average diagnosticity-effect of 4.75%. However, when we eliminate the possibility of substitution effects confounding the results, a meta-analysis of the data provides no indication of any remaining effect of diagnosticity.

  16. Pitfalls in diagnostic radiology

    Energy Technology Data Exchange (ETDEWEB)

    Peh, Wilfred C.G. (ed.) [Khoo Teck Puat Hospital (Singapore). Dept. of Diagnostic Radiology

    2015-04-01

    Only textbook to focus primarily on the topic of pitfalls in diagnostic radiology. Highlights the pitfalls in a comprehensive and systematic manner. Written by experts in different imaging modalities and subspecialties from reputable centers across the world. The practice of diagnostic radiology has become increasingly complex, with the use of numerous imaging modalities and division into many subspecialty areas. It is becoming ever more difficult for subspecialist radiologists, general radiologists, and residents to keep up with the advances that are occurring year on year, and this is particularly true for less familiar topics. Failure to appreciate imaging pitfalls often leads to diagnostic error and misinterpretation, and potential medicolegal problems. Diagnostic errors may be due to various factors such as inadequate imaging technique, imaging artifacts, failure to recognize normal structures or variants, lack of correlation with clinical and other imaging findings, and poor training or inexperience. Many, if not most, of these factors are potentially recognizable, preventable, or correctable. This textbook, written by experts from reputable centers across the world, systematically and comprehensively highlights the pitfalls that may occur in diagnostic radiology. Both pitfalls specific to different modalities and techniques and those specific to particular organ systems are described with the help of numerous high-quality illustrations. Recognition of these pitfalls is crucial in helping the practicing radiologist to achieve a more accurate diagnosis.

  17. MJO Simulation Diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Waliser, D; Sperber, K; Hendon, H; Kim, D; Maloney, E; Wheeler, M; Weickmann, K; Zhang, C; Donner, L; Gottschalck, J; Higgins, W; Kang, I; Legler, D; Moncrieff, M; Schubert, S; Stern, W; Vitart, F; Wang, B; Wang, W; Woolnough, S

    2008-06-02

    The Madden-Julian Oscillation (MJO) interacts with, and influences, a wide range of weather and climate phenomena (e.g., monsoons, ENSO, tropical storms, mid-latitude weather), and represents an important, and as yet unexploited, source of predictability at the subseasonal time scale. Despite the important role of the MJO in our climate and weather systems, current global circulation models (GCMs) exhibit considerable shortcomings in representing this phenomenon. These shortcomings have been documented in a number of multi-model comparison studies over the last decade. However, diagnosis of model performance has been challenging, and model progress has been difficult to track, due to the lack of a coherent and standardized set of MJO diagnostics. One of the chief objectives of the US CLIVAR MJO Working Group is the development of observation-based diagnostics for objectively evaluating global model simulations of the MJO in a consistent framework. Motivation for this activity is reviewed, and the intent and justification for a set of diagnostics is provided, along with specification for their calculation, and illustrations of their application. The diagnostics range from relatively simple analyses of variance and correlation, to more sophisticated space-time spectral and empirical orthogonal function analyses. These diagnostic techniques are used to detect MJO signals, to construct composite life-cycles, to identify associations of MJO activity with the mean state, and to describe interannual variability of the MJO.

  18. {sup 18}F-F.D.G. PET for staging and monitoring of solitary plasmocytomas;La TEP au {sup 18}F-FDG dans le diagnostic et le suivi evolutif des plasmocytomes solitaires

    Energy Technology Data Exchange (ETDEWEB)

    Adib, S.; Robua, D.; Huglo, D.; Steinling, M. [CHU de Lille, rue Michel-Polonovski, Service de medecine nucleaire, hopital Claude-Huriez, 59 - Lille (France); Robua, D.; Leleu, X. [CHU de Lille, rue Michel-Polonovski, Service des maladies du sang, hopital Claude-Huriez, 59 - Lille (France)

    2010-02-15

    Aim: To assess the role of [{sup 18}F]F.D.G.-PET in solitary plasmocytomas with regards to staging, therapeutic follow-up and monitoring. Patients and methods. Twenty consecutive patients were included in the present study when following conditions were met: (1) solitary plasmocytomas histologically confirmed (bone, n = 16; extramedullary, n = 4); (2) [{sup 18}F]F.D.G.-PET scan from July 2004 to April 2009. The clinical follow-up was over than 2 years for 13 patients. Ten patients underwent a post-therapy PET scan. PET scans were visually analysed. Results. PET scan enabled confirmation of all main lesions (sensitivity: 100%) and also detected infra-clinical lesions in eight cases. Follow-up for more than 2 years showed a progression disease into myeloma in five from six cases (83%) with infra clinical lesions at the baseline PET scan. Among 10 patients who underwent post-therapeutic PET scan, six experienced a complete response at the main lesion site and four experienced a partial response. Conclusion: F.D.G.-PET may play an important role in plasmocytomas staging and enables detection of smaller lesions (otherwise undetected). (authors)

  19. Carcinomas epidermóides do pulmão na doença vibroacústica Respiratory squamous cell carcinomas in vibroacoustic disease

    Directory of Open Access Journals (Sweden)

    José Reis Ferreira

    2006-09-01

    de mutagénese em modelos animais e em trabalhadores expostos a RBF: a frequência de trocas de cromátides irmãs em pilotos de helicóptero está aumentada, bem como em modelos animais expostos a ruído e vibrações simultâneos, simulando o ambiente no cockpit de helicópteros.Background: In 1987, the autopsy of a vibroacoustic disease (VAD patient disclosed two tumours: a renal cell carcinoma and a malignant glioma in the brain. Since 1987, malignancy in VAD patients has been under close surveillance. To date, in a universe of 945 individuals, there are 46 cases of malignancies, of which 11 are multiple. Of the 11 cases of respiratory tract tumours, all were squamous cell carcinomas (SqCC. This report focuses on the morphological features of these tumours. Methods: Tumour fragments were collected (endoscopic biopsy or surgery from 11 male VAD patients (ave. age: 58±9 years, 3 non-smokers: 2 in glottis and 9 in the lung. In the 3 non-smokers, 2 had lung tumours and 1 had a glottis tumour. All were employed as or retired aircraft technicians, military or commercial pilots. Fragments were fixed either for light and electron microscopy. Immunohistochemistry studies used chromagranine and synaptophysine staining. Results: All lung tumours were located in the upper right lobe bronchi and were histologically poorly differentiated SqCC (Figs. 1, 2. The search with neuroendocrine markers was negative. The average age of tumour onset in helicopter pilots was below 50 years old while for the other professional groups it was above 50. Nine patients are deceased. The 2 surviving patients are heavy smokers (> 2 packs/day. Smoking habits had no i nfluence on tumour outcome and progression. Discussion: Epidemiological studies indicate that squamous cell carcinomas account for approximately 40% of all lung tumours in men. It seems to be highly relevant that all VAD patient respiratory tract tumours are squamous cell carcinomas. It is not surprising that helicopter pilots are

  20. Metabolomics for laboratory diagnostics.

    Science.gov (United States)

    Bujak, Renata; Struck-Lewicka, Wiktoria; Markuszewski, Michał J; Kaliszan, Roman

    2015-09-10

    Metabolomics is an emerging approach in a systems biology field. Due to continuous development in advanced analytical techniques and in bioinformatics, metabolomics has been extensively applied as a novel, holistic diagnostic tool in clinical and biomedical studies. Metabolome's measurement, as a chemical reflection of a current phenotype of a particular biological system, is nowadays frequently implemented to understand pathophysiological processes involved in disease progression as well as to search for new diagnostic or prognostic biomarkers of various organism's disorders. In this review, we discussed the research strategies and analytical platforms commonly applied in the metabolomics studies. The applications of the metabolomics in laboratory diagnostics in the last 5 years were also reviewed according to the type of biological sample used in the metabolome's analysis. We also discussed some limitations and further improvements which should be considered taking in mind potential applications of metabolomic research and practice. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. [Cytology in uropathological diagnostics].

    Science.gov (United States)

    Gaisa, N T; Lindemann-Docter, K

    2015-11-01

    Cytology in uropathological diagnostics is mainly performed for oncological purposes. The assessment of malignancy by urothelial cell morphology is therefore decisive; however, cytology is only sensitive enough to detect high-grade tumor cells and the different low-grade tumors cannot be reliably diagnosed. Thus, the four-tier classification system of cytological findings (i.e. negative, atypical cells but significance uncertain, suspicious and positive) refers to high-grade tumor cells only. Furthermore, for valid cytological diagnostics not only the cytological specimen but also clinical information on cystoscopy findings and, if applicable, a biopsy should be evaluated together. In difficult differential diagnostic settings, e.g. differentiation between reactive versus neoplastic atypia or difficult to access lesions in the upper urinary tract, additional fluorescence in situ hybridization of cytological preparations might be helpful. At the moment there are no indications for further immunocytology or additional biomarker tests.

  2. Saliva diagnostics - Current views and directions.

    Science.gov (United States)

    Kaczor-Urbanowicz, Karolina Elżbieta; Martin Carreras-Presas, Carmen; Aro, Katri; Tu, Michael; Garcia-Godoy, Franklin; Wong, David Tw

    2017-03-01

    In this review, we provide an update on the current and future applications of saliva for diagnostic purposes. There are many advantages of using saliva as a biofluid. Its collection is fast, easy, inexpensive, and non-invasive. In addition, saliva, as a "mirror of the body," can reflect the physiological and pathological state of the body. Therefore, it serves as a diagnostic and monitoring tool in many fields of science such as medicine, dentistry, and pharmacotherapy. Introduced in 2008, the term "Salivaomics" aimed to highlight the rapid development of knowledge about various "omics" constituents of saliva, including: proteome, transcriptome, micro-RNA, metabolome, and microbiome. In the last few years, researchers have developed new technologies and validated a wide range of salivary biomarkers that will soon make the use of saliva a clinical reality. However, a great need still exists for convenient and accurate point-of-care devices that can serve as a non-invasive diagnostic tool. In addition, there is an urgent need to decipher the scientific rationale and mechanisms that convey systemic diseases to saliva. Another promising technology called liquid biopsy enables detection of circulating tumor cells (CTCs) and fragments of tumor DNA in saliva, thus enabling non-invasive early detection of various cancers. The newly developed technology-electric field-induced release and measurement (EFIRM) provides near perfect detection of actionable mutations in lung cancer patients. These recent advances widened the salivary diagnostic approach from the oral cavity to the whole physiological system, and thus point towards a promising future of salivary diagnostics for personalized individual medicine applications including clinical decisions and post-treatment outcome predictions. Impact statement The purpose of this mini-review is to make an update about the present and future applications of saliva as a diagnostic biofluid in many fields of science such as dentistry

  3. Saliva diagnostics – Current views and directions

    Science.gov (United States)

    Kaczor-Urbanowicz, Karolina Elżbieta; Martin Carreras-Presas, Carmen; Aro, Katri; Tu, Michael; Wong, David TW

    2016-01-01

    In this review, we provide an update on the current and future applications of saliva for diagnostic purposes. There are many advantages of using saliva as a biofluid. Its collection is fast, easy, inexpensive, and non-invasive. In addition, saliva, as a “mirror of the body,” can reflect the physiological and pathological state of the body. Therefore, it serves as a diagnostic and monitoring tool in many fields of science such as medicine, dentistry, and pharmacotherapy. Introduced in 2008, the term “Salivaomics” aimed to highlight the rapid development of knowledge about various “omics” constituents of saliva, including: proteome, transcriptome, micro-RNA, metabolome, and microbiome. In the last few years, researchers have developed new technologies and validated a wide range of salivary biomarkers that will soon make the use of saliva a clinical reality. However, a great need still exists for convenient and accurate point-of-care devices that can serve as a non-invasive diagnostic tool. In addition, there is an urgent need to decipher the scientific rationale and mechanisms that convey systemic diseases to saliva. Another promising technology called liquid biopsy enables detection of circulating tumor cells (CTCs) and fragments of tumor DNA in saliva, thus enabling non-invasive early detection of various cancers. The newly developed technology—electric field-induced release and measurement (EFIRM) provides near perfect detection of actionable mutations in lung cancer patients. These recent advances widened the salivary diagnostic approach from the oral cavity to the whole physiological system, and thus point towards a promising future of salivary diagnostics for personalized individual medicine applications including clinical decisions and post-treatment outcome predictions. Impact statement The purpose of this mini-review is to make an update about the present and future applications of saliva as a diagnostic biofluid in many fields of science such

  4. Diagnostic Imaging for Implants

    Directory of Open Access Journals (Sweden)

    Sanjay M Mallya

    2004-01-01

    Full Text Available Dental implants are a popular modality for permanent tooth replacement. The key to successful implant placement, its subsequent osseointegration and the final prosthetic rehabilitation is proper preoperative assessment. Diagnostic imaging plays an important role in the pre- and post-surgical evaluation process. Imaging is used to evaluate suitability of implant sites, aid in selection of appropriate implants, and finally evaluate implant placement and osseointegration. This article reviews the role of diagnostic imaging in the various phases and the advantages and limitations of the numerous imaging modalities.

  5. Diagnostic Errors Study Findings

    Science.gov (United States)

    ... these efforts are focusing on other settings of care such as ambulatory settings, where many types of health conditions or ... AHRQ recently published a toolkit to help doctors, nurses and medical office ... of primary care office visits involve some type of diagnostic medical ...

  6. Diagnosing Diagnostic Language Assessment

    Science.gov (United States)

    Lee, Yong-Won

    2015-01-01

    Diagnostic language assessment (DLA) is gaining a lot of attention from language teachers, testers, and applied linguists. With a recent surge of interest in DLA, there seems to be an urgent need to assess where the field of DLA stands at the moment and develop a general sense of where it should be moving in the future. The current article, as the…

  7. Beam Diagnostics for Accelerators

    CERN Document Server

    Koziol, Heribert

    2005-01-01

    This introductory course aims at a reasonably complete coverage of beam diagnostic devices used in linear and circular accelerators and in primary beam lines. The weight is on the concepts and the indication of variants, while for technical details the reader is referred to the literature. The present updated version replaces those from previous General Accelerator Physics Courses.

  8. Equivalent Diagnostic Classification Models

    Science.gov (United States)

    Maris, Gunter; Bechger, Timo

    2009-01-01

    Rupp and Templin (2008) do a good job at describing the ever expanding landscape of Diagnostic Classification Models (DCM). In many ways, their review article clearly points to some of the questions that need to be answered before DCMs can become part of the psychometric practitioners toolkit. Apart from the issues mentioned in this article that…

  9. Diagnostic Algorithm for Encephalitis

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2013-12-01

    Full Text Available Diagnostic algorithm for initial evaluation of encephalitis in children is proposed with a consensus statement from the International Encephalitis Consortium, a committee begun in 2010 to serve as a practical aid to clinicians evaluating patients with suspected encephalitis.

  10. Diagnostic and interventional radiology

    Energy Technology Data Exchange (ETDEWEB)

    Vogl, Thomas J. [Klinikum der Johann Wolfgang Goethe-Universitaet, Frankfurt am Main (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie; Reith, Wolfgang [Universitaetsklinikum des Saarlandes, Homburg/Saar (Germany). Klinik fuer Diagnostische und Interventionelle Neuroradiologie; Rummeny, Ernst J. (ed.) [Technische Univ. Muenchen Klinikum rechts der Isar, Muenchen (Germany). Inst. fuer Radiologie

    2016-08-01

    This exceptional book covers all aspects of diagnostic and interventional radiology within one volume, at a level appropriate for the specialist. From the basics through diagnosis to intervention: the reader will find a complete overview of all areas of radiology. The clear, uniform structure, with chapters organized according to organ system, facilitates the rapid retrieval of information. Features include: Presentation of the normal radiological anatomy Classification of the different imaging procedures according to their diagnostic relevance Imaging diagnosis with many reference images Precise description of the interventional options The inclusion of many instructive aids will be of particular value to novices in decision making: Important take home messages and summaries of key radiological findings smooth the path through the jungle of facts Numerous tables on differential diagnosis and typical findings in the most common diseases offer a rapid overview and orientation Diagnostic flow charts outline the sequence of diagnostic evaluation All standard procedures within the field of interventional radiology are presented in a clinically relevant and readily understandable way, with an abundance of illustrations. This is a textbook, atlas, and reference in one: with more than 2500 images for comparison with the reader's own findings. This comprehensive and totally up-to-date book provides a superb overview of everything that the radiology specialist of today needs to know.

  11. Relaxation – Induced by Vibroacoustic Stimulation via a Body Monochord and via Relaxation Music – Is Associated with a Decrease in Tonic Electrodermal Activity and an Increase of the Salivary Cortisol Level in Patients with Psychosomatic Disorders

    Science.gov (United States)

    Sandler, Hubertus; Fendel, Uta; Buße, Petra; Rose, Matthias; Bösel, Rainer; Klapp, Burghard F.

    2017-01-01

    Vibroacoustic stimulation by a Body Monochord can induce relaxation states of various emotional valence. The skin conductance level (SCL) of the tonic electrodermal activity is an indicator of sympathetic arousal of the autonomic nervous system and thus an indicator of the relaxation response. Salivary cortisol is considered to be a stress indicator of the HPA-axis. The effects of the treatment with a Body Monochord and listening to relaxation music (randomized chronological presentation) on SCL and salivary cortisol in relation to the emotional valence of the experience were examined in patients with psychosomatic disorders (N = 42). Salivary cortisol samples were collected immediately before and after the expositions. Subjective experience was measured via self-rating scales. Overall, both the exposure to the Body Monochord as well as the exposure to the relaxation music induced an improvement of patients’ mood and caused a highly significant reduction of SCL. A more emotionally positive experience of relaxation correlated with a slightly stronger reduction of the SCL. Both treatment conditions caused a slight increase in salivary cortisol, which was significant after exposure to the first treatment. The increase of salivary cortisol during a relaxation state is contrary to previous findings. It is possible that the relaxation state was experienced as an emotional challenge, due to inner images and uncommon sensations that might have occurred. PMID:28114399

  12. Relaxation - Induced by Vibroacoustic Stimulation via a Body Monochord and via Relaxation Music - Is Associated with a Decrease in Tonic Electrodermal Activity and an Increase of the Salivary Cortisol Level in Patients with Psychosomatic Disorders.

    Science.gov (United States)

    Sandler, Hubertus; Fendel, Uta; Buße, Petra; Rose, Matthias; Bösel, Rainer; Klapp, Burghard F

    2017-01-01

    Vibroacoustic stimulation by a Body Monochord can induce relaxation states of various emotional valence. The skin conductance level (SCL) of the tonic electrodermal activity is an indicator of sympathetic arousal of the autonomic nervous system and thus an indicator of the relaxation response. Salivary cortisol is considered to be a stress indicator of the HPA-axis. The effects of the treatment with a Body Monochord and listening to relaxation music (randomized chronological presentation) on SCL and salivary cortisol in relation to the emotional valence of the experience were examined in patients with psychosomatic disorders (N = 42). Salivary cortisol samples were collected immediately before and after the expositions. Subjective experience was measured via self-rating scales. Overall, both the exposure to the Body Monochord as well as the exposure to the relaxation music induced an improvement of patients' mood and caused a highly significant reduction of SCL. A more emotionally positive experience of relaxation correlated with a slightly stronger reduction of the SCL. Both treatment conditions caused a slight increase in salivary cortisol, which was significant after exposure to the first treatment. The increase of salivary cortisol during a relaxation state is contrary to previous findings. It is possible that the relaxation state was experienced as an emotional challenge, due to inner images and uncommon sensations that might have occurred.

  13. Relaxation - Induced by Vibroacoustic Stimulation via a Body Monochord and via Relaxation Music - Is Associated with a Decrease in Tonic Electrodermal Activity and an Increase of the Salivary Cortisol Level in Patients with Psychosomatic Disorders.

    Directory of Open Access Journals (Sweden)

    Hubertus Sandler

    Full Text Available Vibroacoustic stimulation by a Body Monochord can induce relaxation states of various emotional valence. The skin conductance level (SCL of the tonic electrodermal activity is an indicator of sympathetic arousal of the autonomic nervous system and thus an indicator of the relaxation response. Salivary cortisol is considered to be a stress indicator of the HPA-axis. The effects of the treatment with a Body Monochord and listening to relaxation music (randomized chronological presentation on SCL and salivary cortisol in relation to the emotional valence of the experience were examined in patients with psychosomatic disorders (N = 42. Salivary cortisol samples were collected immediately before and after the expositions. Subjective experience was measured via self-rating scales. Overall, both the exposure to the Body Monochord as well as the exposure to the relaxation music induced an improvement of patients' mood and caused a highly significant reduction of SCL. A more emotionally positive experience of relaxation correlated with a slightly stronger reduction of the SCL. Both treatment conditions caused a slight increase in salivary cortisol, which was significant after exposure to the first treatment. The increase of salivary cortisol during a relaxation state is contrary to previous findings. It is possible that the relaxation state was experienced as an emotional challenge, due to inner images and uncommon sensations that might have occurred.

  14. Vanishing "tattoo" multisensor for biomedical diagnostics

    Science.gov (United States)

    Moczko, E.; Meglinski, I.; Piletsky, S.

    2008-02-01

    Currently, precise non-invasive diagnostics systems for the real-time multi detection and monitoring of physiological parameters and chemical analytes in the human body are urgently required by clinicians, physiologists and bio-medical researchers. We have developed a novel cost effective smart 'vanishing tattoo' (similar to temporary child's tattoos) consisting of environmental-sensitive dyes. Painlessly impregnated into the skin the smart tattoo is capable of generating optical/fluorescence changes (absorbance, transmission, reflectance, emission and/or luminescence within UV, VIS or NIR regions) in response to physical or chemical changes. These changes allow the identification of colour pattern changes similar to bar-code scanning. Such a system allows an easy, cheap and robust comprehensive detection of various parameters and analytes in a small volume of sample (e.g. variations in pH, temperature, ionic strength, solvent polarity, presence of redox species, surfactants, oxygen). These smart tattoos have possible applications in monitoring the progress of disease and transcutaneous drug delivery. The potential of this highly innovative diagnostic tool is wide and diverse and can impact on routine clinical diagnostics, general therapeutic management, skin care and cosmetic products testing as well as fundamental physiological investigations.

  15. New results in human eye laser diagnostics

    Science.gov (United States)

    Shubochkin, L. P.; Tuchin, Valery V.

    1991-05-01

    Different laser spectroscopy methods are applicable in ophthalmology for diseases diagnostics and biotissues state monitoring. Both groups of micro- and macrodiagnostics methods, especially laser Raman, resonance Raman, surface-enhanced Raman (SERS), Raman microprobe, fluorescence, Raman/fluorescence, infrared Fourier- transformation absorption method (FT-IR) and the method with the use of total reflection prism (ATR/FT-IR), FT-Raman , elastic and quasi-elastic light scattering spectroscopy have good possibilities in human and mammalia eye tissues diagnostics.''2 Microdiagnostics is realyzed with the help of all kinds of Raman, absorption and fluorescence spectroscopy and allows to study macromolecular structure and biochemical changes in eye tissues. These methods are very promising in analyzing of cataract mechanism formation, but not all of them can be used in early human cataract diagnostics, as far as they require comparatively high levels of laser radiation power. For example, modern means of Raman spectroscopy (computer controlled optical multichannel analyzer) in early cataract diagnostics need the crystalline lens has to be radiated by Ar laser with the power of 1 mW during is (Refs. 2,4). Macrodiagnostics of biotissues exploit such methods as elastic and quasi-elastic light scattering, interferometry, polarimetry and specle optics. These methods give information about form and dimensions of individual scattering particale of optically inhomogeneous media, distribution function of particales dimensions, optical constants, static characteristics of particles spatial location and presence of anisotropy. The investigations carried out for different eye. tissues demonstrate the possibility of use elastic light scattering techniques to diseases diagnostics and biotissues state monitoring in ophthalmology. Elastic scattering, interferometry and polarimetry methods require low levels of laser radiation power and comparatively simple installation for their

  16. The Implication of Diagnostic Errors.

    Science.gov (United States)

    Govindarajan, Raghav

    2017-10-01

    Diagnostic errors are mistakes in the diagnostic process that lead to a misdiagnosis, a missed diagnosis, or a delayed diagnosis. While the past decade's impetus to improve patient safety has focused on medication errors, health care-associated infections, and postsurgical complications, diagnostic errors have received comparatively less attention. Diagnostic errors will continue to play a major role in the patient safety and quality improvement movement because of their burden on care and their financial burden. Developing a patient-partnered diagnostic approach with self-reflection and awareness of cognitive biases is the key to minimizing the impact of diagnostic errors.

  17. Ares I-X Ground Diagnostic Prototype

    Science.gov (United States)

    Schwabacher, Mark A.; Martin, Rodney Alexander; Waterman, Robert D.; Oostdyk, Rebecca Lynn; Ossenfort, John P.; Matthews, Bryan

    2010-01-01

    The automation of pre-launch diagnostics for launch vehicles offers three potential benefits: improving safety, reducing cost, and reducing launch delays. The Ares I-X Ground Diagnostic Prototype demonstrated anomaly detection, fault detection, fault isolation, and diagnostics for the Ares I-X first-stage Thrust Vector Control and for the associated ground hydraulics while the vehicle was in the Vehicle Assembly Building at Kennedy Space Center (KSC) and while it was on the launch pad. The prototype combines three existing tools. The first tool, TEAMS (Testability Engineering and Maintenance System), is a model-based tool from Qualtech Systems Inc. for fault isolation and diagnostics. The second tool, SHINE (Spacecraft Health Inference Engine), is a rule-based expert system that was developed at the NASA Jet Propulsion Laboratory. We developed SHINE rules for fault detection and mode identification, and used the outputs of SHINE as inputs to TEAMS. The third tool, IMS (Inductive Monitoring System), is an anomaly detection tool that was developed at NASA Ames Research Center. The three tools were integrated and deployed to KSC, where they were interfaced with live data. This paper describes how the prototype performed during the period of time before the launch, including accuracy and computer resource usage. The paper concludes with some of the lessons that we learned from the experience of developing and deploying the prototype.

  18. The current and future state of companion diagnostics

    Directory of Open Access Journals (Sweden)

    Agarwal A

    2015-03-01

    consolidation and global expansion that the industry has already begun. Despite these potential obstacles, companion diagnostics have become one of the hottest areas of deal making in the diagnostic space in recent years, and the future trends continue to look bright. Keywords: companion diagnostics, theranostics, personalized medicine, prognosis, monitoring

  19. Clinical and diagnostic utility of saliva as a non-invasive diagnostic fluid: a systematic review

    OpenAIRE

    Nunes, Lazaro Alessandro Soares; MUSSAVIRA, Sayeeda; Bindhu, Omana Sukumaran

    2015-01-01

    This systematic review presents the latest trends in salivary research and its applications in health and disease. Among the large number of analytes present in saliva, many are affected by diverse physiological and pathological conditions. Further, the non-invasive, easy and cost-effective collection methods prompt an interest in evaluating its diagnostic or prognostic utility. Accumulating data over the past two decades indicates towards the possible utility of saliva to monitor overall hea...

  20. Nanobiosensors in diagnostics

    Directory of Open Access Journals (Sweden)

    Alejandro Chamorro-Garcia

    2016-11-01

    Full Text Available Medical diagnosis has been greatly improved thanks to the development of new techniques capable of performing very sensitive detection and quantifying certain parameters. These parameters can be correlated with the presence of specific molecules and their quantity. Unfortunately, these techniques are demanding, expensive, and often complicated. On the other side, progress in other fields of science and technology has contributed to the rapid growth of nanotechnology. Although being an emerging discipline, nanotechnology has raised huge interest and expectations. Most of the enthusiasm comes from new possibilities and properties of nanomaterials. Biosensors (simple, robust, sensitive, cost-effective combined with nanomaterials, also called nanobiosensors, are serving as bridge between advanced detection/diagnostics and daily/routine tests. Here we review some of the latest applications of nanobiosensors in diagnostics field.

  1. [Genetic diagnostics for cardiomyopathies].

    Science.gov (United States)

    Czepluch, Frauke; Wollnik, Bernd; Hasenfuß, Gerd

    2017-05-01

    Cardiomyopathies often have a genetic etiology. New genetic diagnostic strategies based on next generation sequencing (NGS)-approaches will continuously increase our knowledge about the genetic basis of cardiomyopathies within the following years. Diagnostics and therapy of rare, genetically-induced cardiac diseases increasingly require special cardiac and genetic knowledge. Interestingly, mutations in the same gene or even identical gene mutations can be associated with different cardiomyopathy phenotypes and can exhibit incomplete penetrance or variable expressivity. In the future, the correct interpretation and classification of novel gene variants identified in patients with inherited cardiomyopathy forms will represent a great challenge. Genetic counselling and - if appropriate - subsequent genetic testing for cardiomyopathy patients and their asymptomatic relatives is essential for an early diagnosis of the disease, a prognostic evaluation and possibly for the start of preventive or therapeutic measures. © Georg Thieme Verlag KG Stuttgart · New York.

  2. Obesitiy and Diagnostic Radiology

    Directory of Open Access Journals (Sweden)

    Erkan Gokce

    2013-09-01

    Full Text Available Use of medical imaging depending upon the comorbidity diseases and bariatric diseased for obese people has increased along with the increase at obesity prevalence. Due to large body structure and increased fatty tissue in obese patients, it is hard to carry out radiological studies and obtain images on diagnostic quality. Moreover, obese patients and #8217; subjecting to more radiation dose in examinations including ionizing radiation is another disadvantage. In order to perform diagnostic imaging process in obese patients, imaging equipment in accordance with the patient weight and diameter and examination rooms should be provided; and examination parameters should be organized according to the patient in a way that can be obtained the best imaging quality. [J Contemp Med 2013; 3(3.000: 218-226

  3. Cardiovascular modeling and diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Kangas, L.J.; Keller, P.E.; Hashem, S.; Kouzes, R.T. [Pacific Northwest Lab., Richland, WA (United States)

    1995-12-31

    In this paper, a novel approach to modeling and diagnosing the cardiovascular system is introduced. A model exhibits a subset of the dynamics of the cardiovascular behavior of an individual by using a recurrent artificial neural network. Potentially, a model will be incorporated into a cardiovascular diagnostic system. This approach is unique in that each cardiovascular model is developed from physiological measurements of an individual. Any differences between the modeled variables and the variables of an individual at a given time are used for diagnosis. This approach also exploits sensor fusion to optimize the utilization of biomedical sensors. The advantage of sensor fusion has been demonstrated in applications including control and diagnostics of mechanical and chemical processes.

  4. PROcess Based Diagnostics PROBE

    Science.gov (United States)

    Clune, T.; Schmidt, G.; Kuo, K.; Bauer, M.; Oloso, H.

    2013-01-01

    Many of the aspects of the climate system that are of the greatest interest (e.g., the sensitivity of the system to external forcings) are emergent properties that arise via the complex interplay between disparate processes. This is also true for climate models most diagnostics are not a function of an isolated portion of source code, but rather are affected by multiple components and procedures. Thus any model-observation mismatch is hard to attribute to any specific piece of code or imperfection in a specific model assumption. An alternative approach is to identify diagnostics that are more closely tied to specific processes -- implying that if a mismatch is found, it should be much easier to identify and address specific algorithmic choices that will improve the simulation. However, this approach requires looking at model output and observational data in a more sophisticated way than the more traditional production of monthly or annual mean quantities. The data must instead be filtered in time and space for examples of the specific process being targeted.We are developing a data analysis environment called PROcess-Based Explorer (PROBE) that seeks to enable efficient and systematic computation of process-based diagnostics on very large sets of data. In this environment, investigators can define arbitrarily complex filters and then seamlessly perform computations in parallel on the filtered output from their model. The same analysis can be performed on additional related data sets (e.g., reanalyses) thereby enabling routine comparisons between model and observational data. PROBE also incorporates workflow technology to automatically update computed diagnostics for subsequent executions of a model. In this presentation, we will discuss the design and current status of PROBE as well as share results from some preliminary use cases.

  5. ESPC Integrated Skill Diagnostics

    Science.gov (United States)

    2015-09-30

    1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. ESPC Integrated Skill Diagnostics Maria Flatau Naval...quantitative skill metrics to assess the advancements in the Earth System Prediction Capability (ESPC). This work will also implement automated...indicates the lack of skilled forecasts beyond 10 days. Lin et al. (2005, 2009) indicates that the skill of polar mode forecasts depends on MJO amplitude

  6. [Diagnostic means for tuberculosis].

    Science.gov (United States)

    Jabri, H; Lakhdar, N; El Khattabi, W; Afif, H

    2016-10-01

    Tuberculosis is a public health problem. In recent years, there is a change in the epidemiological profile of tuberculosis. The diagnosis of tuberculosis is based on clinical and radiological arguments but confirmation is bacteriological and/or histological. Culture remains the gold standard. Technological progress especially in molecular biology provides the clinician now new means of tuberculosis diagnostics. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  7. Performance of Advanced Light Source particle beam diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Hinkson, J.

    1993-05-01

    The Advanced Light Source (ALS), a third-generation synchrotron radiation facility, is complete. The particle beam diagnostics have been installed and tested. The beam injection systems have been running for two years. We have performance data on beam position monitors, beam intensity monitors, scintillators, beam collimators, a 50 {Omega} Faraday cup, and broad-band striplines and kickers used in the linac, transport lines, and the booster synchrotron. The single-turn monitoring capability of the booster beam position monitoring system has been particularly useful for studying beam dynamics. Beam diagnostics for the storage ring are being commissioned. In this paper we describe each instrument, show its performance, and outline how the instruments are controlled and their output data displayed.

  8. Arduino Based Infant Monitoring System

    Science.gov (United States)

    Farhanah Mohamad Ishak, Daing Noor; Jamil, Muhammad Mahadi Abdul; Ambar, Radzi

    2017-08-01

    This paper proposes a system for monitoring infant in an incubator and records the relevant data into a computer. The data recorded by the system can be further referred by the neonatal intensive care unit (NICU) personnel for diagnostic or research purposes. The study focuses on designing the monitoring system that consists of an incubator equipped with humidity sensor to measure the humidity level, and a pulse sensor that can be attached on an infant placed inside the incubator to monitor infant’s heart pulse. The measurement results which are the pulse rate and humidity level are sent to the PC via Arduino microcontroller. The advantage of this system will be that in the future, it may also enable doctors to closely monitor the infant condition through local area network and internet. This work is aimed as an example of an application that contributes towards remote tele-health monitoring system.

  9. SNS Diagnostics Timing Integration

    CERN Document Server

    Long, Cary D; Murphy, Darryl J; Pogge, James; Purcell, John D; Sundaram, Madhan

    2005-01-01

    The Spallation Neutron Source (SNS) accelerator systems will deliver a 1.0 GeV, 1.4 MW proton beam to a liquid mercury target for neutron scattering research. The accelerator complex consists of a 1 GeV linear accelerator, an accumulator ring and associated transport lines. The SNS diagnostics platform is PC-based running Windows XP Embedded for its OS and LabVIEW as its programming language. Coordinating timing among the various diagnostics instruments with the generation of the beam pulse is a challenging task that we have chosen to divide into three phases. First, timing was derived from VME based systems. In the second phase, described in this paper, timing pulses are generated by an in house designed PCI timing card installed in ten diagnostics PCs. Using fan-out modules, enough triggers were generated for all instruments. This paper describes how the Timing NAD (Network Attached Device) was rapidly developed using our NAD template, LabVIEW's PCI driver wizard, and LabVIEW Channel Access library. The NAD...

  10. Dosimetry in diagnostic radiology.

    Science.gov (United States)

    Meghzifene, Ahmed; Dance, David R; McLean, Donald; Kramer, Hans-Michael

    2010-10-01

    Dosimetry is an area of increasing importance in diagnostic radiology. There is a realisation amongst health professionals that the radiation dose received by patients from modern X-ray examinations and procedures can be at a level of significance for the induction of cancer across a population, and in some unfortunate instances, in the acute damage to particular body organs such as skin and eyes. The formulation and measurement procedures for diagnostic radiology dosimetry have recently been standardised through an international code of practice which describes the methodologies necessary to address the diverging imaging modalities used in diagnostic radiology. Common to all dosimetry methodologies is the measurement of the air kerma from the X-ray device under defined conditions. To ensure the accuracy of the dosimetric determination, such measurements need to be made with appropriate instrumentation that has a calibration that is traceable to a standards laboratory. Dosimetric methods are used in radiology departments for a variety of purposes including the determination of patient dose levels to allow examinations to be optimized and to assist in decisions on the justification of examination choices. Patient dosimetry is important for special cases such as for X-ray examinations of children and pregnant patients. It is also a key component of the quality control of X-ray equipment and procedures. Copyright © 2010. Published by Elsevier Ireland Ltd.

  11. Molecular diagnostics of periodontitis.

    Science.gov (United States)

    Korona-Głowniak, Izabela; Siwiec, Radosław; Berger, Marcin; Malm, Anna; Szymańska, Jolanta

    2017-01-28

    The microorganisms that form dental plaque are the main cause of periodontitis. Their identification and the understanding of the complex relationships and interactions that involve these microorganisms, environmental factors and the host's health status enable improvement in diagnostics and targeted therapy in patients with periodontitis. To this end, molecular diagnostics techniques (both techniques based on the polymerase chain reaction and those involving nucleic acid analysis via hybridization) come increasingly into use. On the basis of a literature review, the following methods are presented: polymerase chain reaction (PCR), real-time polymerase chain reaction (real-time PCR), 16S rRNA-encoding gene sequencing, checkerboard and reverse-capture checkerboard hybridization, microarrays, denaturing gradient gel electrophoresis (DGGE), temperature gradient gel electrophoresis (TGGE), as well as terminal restriction fragment length polymorphism (TRFLP) and next generation sequencing (NGS). The advantages and drawbacks of each method in the examination of periopathogens are indicated. The techniques listed above allow fast detection of even small quantities of pathogen present in diagnostic material and prove particularly useful to detect microorganisms that are difficult or impossible to grow in a laboratory.

  12. Molecular diagnostics of periodontitis

    Directory of Open Access Journals (Sweden)

    Izabela Korona-Głowniak

    2017-01-01

    Full Text Available The microorganisms that form dental plaque are the main cause of periodontitis. Their identification and the understanding of the complex relationships and interactions that involve these microorganisms, environmental factors and the host’s health status enable improvement in diagnostics and targeted therapy in patients with periodontitis. To this end, molecular diagnostics techniques (both techniques based on the polymerase chain reaction and those involving nucleic acid analysis via hybridization come increasingly into use. On the basis of a literature review, the following methods are presented: polymerase chain reaction (PCR, real-time polymerase chain reaction (real-time PCR, 16S rRNA-encoding gene sequencing, checkerboard and reverse-capture checkerboard hybridization, microarrays, denaturing gradient gel electrophoresis (DGGE, temperature gradient gel electrophoresis (TGGE, as well as terminal restriction fragment length polymorphism (TRFLP and next generation sequencing (NGS. The advantages and drawbacks of each method in the examination of periopathogens are indicated. The techniques listed above allow fast detection of even small quantities of pathogen present in diagnostic material and prove particularly useful to detect microorganisms that are difficult or impossible to grow in a laboratory.

  13. Spectroscopic diagnostics of high temperature plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Moos, W.

    1990-01-01

    A three-year research program for the development of novel XUV spectroscopic diagnostics for magnetically confined fusion plasmas is proposed. The new diagnostic system will use layered synthetic microstructures (LSM) coated, flat and curved surfaces as dispersive elements in spectrometers and narrow band XUV filter arrays. In the framework of the proposed program we will develop impurity monitors for poloidal and toroidal resolved measurements on PBX-M and Alcator C-Mod, imaging XUV spectrometers for electron density and temperature fluctuation measurements in the hot plasma core in TEXT or other similar tokamaks and plasma imaging devices in soft x-ray light for impurity behavior studies during RF heating on Phaedrus T and carbon pellet ablation in Alcator C-Mod. Recent results related to use of multilayer in XUV plasma spectroscopy are presented. We also discuss the latest results reviewed to q{sub o} and local poloidal field measurements using Zeeman polarimetry.

  14. Video integrated measurement system. [Diagnostic display devices

    Energy Technology Data Exchange (ETDEWEB)

    Spector, B.; Eilbert, L.; Finando, S.; Fukuda, F.

    1982-06-01

    A Video Integrated Measurement (VIM) System is described which incorporates the use of various noninvasive diagnostic procedures (moire contourography, electromyography, posturometry, infrared thermography, etc.), used individually or in combination, for the evaluation of neuromusculoskeletal and other disorders and their management with biofeedback and other therapeutic procedures. The system provides for measuring individual diagnostic and therapeutic modes, or multiple modes by split screen superimposition, of real time (actual) images of the patient and idealized (ideal-normal) models on a video monitor, along with analog and digital data, graphics, color, and other transduced symbolic information. It is concluded that this system provides an innovative and efficient method by which the therapist and patient can interact in biofeedback training/learning processes and holds considerable promise for more effective measurement and treatment of a wide variety of physical and behavioral disorders.

  15. Saliva as a potential diagnostic tool.

    Science.gov (United States)

    Deepa, T; Thirrunavukkarasu, N

    2010-07-01

    Saliva is a complex fluid consisting of secretions from the major and minor salivary glands. Gland-specific saliva can be used to diagnose any pathology from the specific major salivary gland. Whole saliva has serum constituents that are derived from the local vasculature of the salivary glands and gingival crevicular fluid. Saliva, as a diagnostic fluid, has distinctive advantages over serum as whole saliva can be collected non-invasively by individuals with limited training using simple equipments. This review aimed to explore the diagnostic applications of saliva in systemic and oral diseases. Analysis of saliva can offer a cost-effective approach to screen for a larger population. Salivary analysis may be useful for diagnosing systemic oral disorders, as well as for monitoring hormone and therapeutic levels of drug.

  16. Automated diagnostic kiosk for diagnosing diseases

    Science.gov (United States)

    Regan, John Frederick; Birch, James Michael

    2014-02-11

    An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes.

  17. An Ecological Diagnostic Classification Plan.

    Science.gov (United States)

    Hurst, James C.; McKinley, Donna L.

    1988-01-01

    Discusses the value of diagnostic classification systems to counseling professionals. Describes the Ecological Diagnostic Classification Plan, an approach to diagnosis that includes the environment as a possible cause of pathology and target of intervention. (Author/KS)

  18. On-board Diagnostics Framework

    OpenAIRE

    Olsson, Patrik

    2012-01-01

    For as long as complex machines have been around there has also been a need for accurate diagnostic and prognostic capabilities. Over the last decades there have been many attempts to develop and implement systems with various degrees of diagnostic and prognostic abilities, some successful some not. This master thesis presents a software architecture that is used to implement an on-board diagnostic framework capable of advanced diagnostics and prognostics in industrial vehicles. The presented...

  19. Use of saliva as a diagnostic fluid in dentistry

    OpenAIRE

    Todorović Tatjana; Dožić Ivan; Pavlica Dušan; Marković Dejan; Ivanović Mirjana; Brajović Gavrilo; Stefanović Gordana; Mirković Silvija; Anđelski Biljana

    2005-01-01

    Saliva is a secretion of the salivary and mucous glands and is of major importance in the maintainance of oral health. Over the last few decades, saliva has been evaluated as a diagnostic fluid in medicine for determining systemic disease markers as well as for monitoring numerous drugs, narcotics, and hormones. The biochemical analysis of saliva is particularly important in dentistry. The estimation of the risk of appearance and diagnosis of disease, monitoring of disease progression, evalua...

  20. Expert system applications in support of system diagnostics and prognostics at EBR-II

    Energy Technology Data Exchange (ETDEWEB)

    Lehto, W.K.; Gross, K.C. (Argonne National Lab., Idaho Falls, ID (USA); Argonne National Lab., IL (USA))

    1989-01-01

    Expert systems have been developed to aid in the monitoring and diagnostics of the Experimental Breeder Reactor-II (EBR-II) at the Idaho National Engineering Laboratory (INEL) in Idaho Falls, Idaho. Systems have been developed for failed fuel surveillance and diagnostics and reactor coolant pump monitoring and diagnostics. A third project is being done jointly by ANL-W and EG G Idaho to develop a transient analysis system to enhance overall plant diagnostic and prognostic capability. The failed fuel surveillance and diagnosis system monitors, processes, and interprets information from nine key plant sensors. It displays to the reactor operator diagnostic information needed to make proper decisions regarding technical specification conformance during reactor operation with failed fuel. 8 refs., 9 figs., 2 tabs.

  1. Modern methods of early diagnostics of juvenile arthritis

    Directory of Open Access Journals (Sweden)

    Chernenkov Y.V.

    2013-06-01

    Full Text Available The problem of inflammatory diseases of joints is one of the most important issues in the pediatrics. Nowadays the significant attention in this sphere is paid to the search of new accurate criteria of diagnostics. It will help estimate the severity of disease, determine the prognosis, choose the method of treatment and monitoring and evaluate the efficacy of the therapy.

  2. Diagnostic efficacy of handheld devices for emergency radiologic consultation.

    LENUS (Irish Health Repository)

    Toomey, Rachel J

    2010-02-01

    Orthopedic injury and intracranial hemorrhage are commonly encountered in emergency radiology, and accurate and timely diagnosis is important. The purpose of this study was to determine whether the diagnostic accuracy of handheld computing devices is comparable to that of monitors that might be used in emergency teleconsultation.

  3. Investigations of certain problems in reactor noise diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Karlsson, Joakim

    1997-06-01

    A number of problems in reactor noise diagnostics have been investigated within the framework of the present thesis. The papers presented cover three relatively different areas, namely neutron noise induced by small vibrations of a strong absorber, the decomposition of noise in BWRs with application to stability monitoring, and fluctuation analysis of soft x-ray signals from fusion plasmas. 18 refs, 6 figs.

  4. Electrocardiogram as prognostic and diagnostic parameter in follow ...

    African Journals Online (AJOL)

    Mohamed Sadaka

    2012-10-27

    Oct 27, 2012 ... Aim: To determine whether heart failure (ECG) conveys prognostic and diagnostic information in patients with HF. ... history taking, clinical examination, standard 12 lead ECG (at admission, discharge, and 3 month follow up) for ..... ECG monitoring and follow up are incorporated in clini- cian's routine work ...

  5. Sensorless PV Array Diagnostic Method for Residential PV Systems

    DEFF Research Database (Denmark)

    Sera, Dezso; Spataru, Sergiu; Mathe, Laszlo

    2011-01-01

    This work proposes a temperature and irradiance sensorless diagnostic method suitable for small residential PV installations, focusing on detection of partial shadows. The method works by detection of failures in crystalline silicone PV arrays by concomitant monitoring of some of their key...

  6. Potential diagnostic applications of biosensors: current and future directions

    OpenAIRE

    Song, Shiping; Xu, Hui; Fan, Chunhai

    2006-01-01

    This review describes recent advances in biosensors of potential clinical applications. Biosensors are becoming increasingly important and practical tools in pathogen detection, molecular diagnostics, environmental monitoring, food safety control as well as in homeland defense. Electrochemical biosensors are particularly promising toward these goals arising due to several combined advantages including low-cost, operation convenience, and miniaturized devices. We review the clinical applicatio...

  7. Cryogenic systems advanced monitoring, fault diagnostics, and predictive maintenance

    CERN Document Server

    Arpaia, Pasquale

    2017-01-01

    Cryogenics, the study and technology of materials and systems at very low temperature, is widely used for sensors and instruments requiring very highly precise measurements with low electrical resistance, especially for measurements of materials and energies at a very small scale. Thus, the need to understand how instruments operate and perform over time at temperatures below -2920 F (-1800 C) is critical, for applications from Magnetic Resonance Imaging (MRI) to Nuclear Magnetic Resonance Spectroscopy to instrumentation for particle accelerators of all kinds. This book brings to the reader guidance learned from work at the European Laboratory for Nuclear Research (CERN), and its large scale particle accelerator in Switzerland to help engineers and technicians implement best practices in instrumentation at cryogenic temperatures, including a better understanding of fault detection and predictive maintenance. Special problems with devices like flow meters, pressure gauges, and temperature gauges when operating...

  8. In Vivo Optical Measurements for Diagnostics and Monitoring of Treatment

    NARCIS (Netherlands)

    R.L.P. van Veen (Robert)

    2006-01-01

    textabstractThe interaction of light with tissue and its use for medical purposes has been under investigation for centuries. Since the early nineteen sixties, the development of novel optical technology and advances in laser design/technology allowed a wide range of innovative applications in

  9. ON IMPROVEMENT OF MONITORING OVER MICROBIOLOGICAL DIAGNOSTICS OF TUBERCULOSIS

    Directory of Open Access Journals (Sweden)

    E. V. Sevastianova

    2016-01-01

    Full Text Available The articles provides justification of principles and main provisions governing specialists who developed standard unified reporting forms for bacteriological laboratories of medical TB units in the Russian Federation.

  10. The diagnostic and monitoring value of serum anti-mutated ...

    African Journals Online (AJOL)

    The criteria may be insufficient for the diagnosis of early RA as they are based upon measurements of disease classification predominately featuring manifestations typical of later-stage disease. Measurement of serum anti-mutated citrullinated vimentin antibodies (MCV) has been shown to be a better marker for early adult ...

  11. 21 CFR 892.1540 - Nonfetal ultrasonic monitor.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Nonfetal ultrasonic monitor. 892.1540 Section 892...) MEDICAL DEVICES RADIOLOGY DEVICES Diagnostic Devices § 892.1540 Nonfetal ultrasonic monitor. (a) Identification. A nonfetal ultrasonic monitor is a device that projects a continuous high-frequency sound wave...

  12. 21 CFR 886.1510 - Eye movement monitor.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Eye movement monitor. 886.1510 Section 886.1510...) MEDICAL DEVICES OPHTHALMIC DEVICES Diagnostic Devices § 886.1510 Eye movement monitor. (a) Identification. An eye movement monitor is an AC-powered device with an electrode intended to measure and record...

  13. Instrumentation and diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Nakaishi, C.V.; Bedick, R.C.

    1990-12-01

    This Technology Status Report describes research and accomplishments for the Instrumentation and Diagnostics (I D) Projects within the Advanced Research and Technology Development (AR TD) Program of the United States Department of Energy (DOE) Office of Fossil Energy (FE). Process understanding and control can be improved through the development of advanced instrumentation and diagnostics. The thrust of the I D Projects is to further develop existing measurement and control techniques for application to advanced coal-based technologies. Project highlights are: an inductively coupled plasma (ICP) instrument has been developed to analyze trace elements in gasification and combustion process streams. An in situ two-color Mie scattering technique with LSS can simultaneously measure the size, velocity, and elemental composition of coal particles during combustion. A high-temperature, fluorescence thermometry technique has accurately measured gas temperatures during field testing in combustion and gasification environments. Expert systems have been developed to improve the control of advanced coal-based processes. Capacitance flowmeters were developed to determine the mass flowrate, solid volume fraction, and particle velocities of coal slurries. 32 refs., 9 figs.

  14. Diagnostic Technologies in Practice

    Science.gov (United States)

    Steinberg, Malcolm; Kwag, Michael; Chown, Sarah A.; Doupe, Glenn; Trussler, Terry; Rekart, Michael; Gilbert, Mark

    2015-01-01

    Diagnosing HIV-positive gay men through enhanced testing technologies that detect acute HIV infection (AHI) or recent HIV infection provides opportunities for individual and population health benefits. We recruited 25 men in British Columbia who received an acute (n = 13) or recent (n = 12) HIV diagnosis to engage in a longitudinal multiple-methods study over one year or longer. Our thematic analysis of baseline qualitative interviews revealed insights within men’s accounts of technologically mediated processes of HIV discovery and diagnosis. Our analysis illuminated the dialectic of new HIV technologies in practice by considering the relationship between advances in diagnostics (e.g., nucleic acid amplification tests) and the users of these medical technologies in clinical settings (e.g., clients and practitioners). Technological innovations and testing protocols have shifted experiences of learning of one’s HIV-positive status; these innovations have created new diagnostic categories that require successful interpretation and translation to be rendered meaningful, to alleviate uncertainty, and to support public health objectives. PMID:25201583

  15. Radiation hardening of diagnostics

    Science.gov (United States)

    Siemon, R. E.

    The world fusion program has advanced to the stage where it is appropriate to construct a number of devices for the purpose of burning DT fuel. In these next-generation experiments, the expected flux and fluence of 14 MeV neutrons and associated gamma rays will pose a significant challenge to the operation and diagnostics of the fusion device. Radiation effects include structural damage to materials such as vacuum windows and seals, modifications to electrical properties such as electrical conductivity and dielectric strength and impaired optical properties such as reduced transparency and luminescence of windows and fiber optics during irradiation. In preparation for construction and operation of these new facilities, the fusion diagnostics community needs to work with materials scientists to develop a better understanding of radiation effects, and to undertake a testing program aimed at developing workable solutions for this multi-faceted problem. A unique facility to help in this regard is the Los Alamos Spallation Radiation Effects Facility, a neutron source located at the beam stop of the world's most powerful accelerator, the Los Alamos Meson Physics Facility (LAMPF). The LAMPF proton beam generates 10(exp 16) neutrons per second because of spallation'reactions when the protons collide with the copper nuclei in the beam stop.

  16. Reflectometry diagnostics on TCV

    Science.gov (United States)

    Molina Cabrera, Pedro; Coda, Stefano; Porte, Laurie; Offeddu, Nicola; Tcv Team

    2017-10-01

    Both profile reflectometer and Doppler back-scattering (DBS) diagnostics are being developed for the TCV Tokamak using a steerable quasi-optical launcher and universal polarizers. First results will be presented. A pulse reflectometer is being developed to complement Thomson Scattering measurements of electron density, greatly increasing temporal resolution and also effectively enabling fluctuation measurements. Pulse reflectometry consists of sending short pulses of varying frequency and measuring the roundtrip group-delay with precise chronometers. A fast arbitrary waveform generator is used as a pulse source feeding frequency multipliers that bring the pulses to V-band. A DBS diagnostic is currently operational in TCV. DBS may be used to infer the perpendicular velocity and wave number spectrum of electron density fluctuations in the 3-15 cm-1 wave-number range. Off-the-shelf transceiver modules, originally used for VNA measurements, are being used in a Doppler radar configuration. See author list of S. Coda et al., 2017 Nucl. Fusion 57 102011.

  17. Magnetic Diagnostics for Ignitor

    Science.gov (United States)

    Alladio, F.

    2005-10-01

    All the electromagnetic diagnostics commonly used in present experiments to measure plasma parameters such as current, loop voltage, horizontal and vertical position, plasma beta, toroidal and poloidal modes, etc., are adopted for Ignitor. The moderate neutron fluence and very intense neutron flux expected in Ignitor demand the use of fully inorganic insulating materials, for which permanent radiation damage should be limited, but transient, reversible effects cannot be excluded. More data is needed to verify the sensitivity of the chosen materials to the radiation background, but in the meantime, an R&D program has started with the purpose of selecting insulator materials, testing impregnation techniques, verification of installation feasibility for all types of magnetic diagnostic coils. Full size prototypes are being manufactured. The magnetic coils system must be closely integrated with the plasma chamber as it requires early installation. While the initial positioning of the in-vessel components should be possible with relative ease (before the welding of the individual sectors of the plasma chamber), their replacement and maintenance in the course of the experimental life of the machine can be problematic. Therefore, an adequate level of redundancy is being considered.

  18. Current possibilities of chorioretinites diagnostics

    Directory of Open Access Journals (Sweden)

    O. V. Chudinova

    2014-07-01

    observation using OCt and monitoring of regional hemodynamics using USDG in patients with chorioreti- nites of different etiology are visualized the complications of the posterior part of the eye at early stages, to determine inflammatory process reactivation in time, as well as the dynamics of inflammation curing processes through the treatment performed. the prelimi- nary results obtained, as well as further studying this problem will allow to develop more constructive approaches to chorioretinites diagnostics.

  19. Diagnostic test evaluation for Trichinella infections in pigs: a renewed interaction between diagnostic test data and their statistical analysis

    NARCIS (Netherlands)

    Dopfer, D.D.V.; Maassen, C.B.M.; Achterberg, R.P.; Giessen, van der J.W.B.; Teunis, P.; Buist, W.G.; Molina, V.; Guarnera, E.; Gonzales, M.; Krivokapich, S.; Rodriguez, M.; Peralta, J.L.; Trabattoni, H.; Larrieu, E.; Engel, B.

    2006-01-01

    To evaluate the usefulness of serological tests applied to monitor Trichinella free herds, Bayesian methodology was used to estimate the diagnostic test parameters: sensitivity, specificity and prevalence in the absence of a Gold Standard test. In the absence of Dutch serum samples for positive

  20. An Assessment of Performance and Condition Monitoring Requirements of Foreign Marine Diesel Propulsion Systems

    National Research Council Canada - National Science Library

    1982-01-01

    This report presents a synopsis of the requirements and recommended practices for diesel engine diagnostic, performance and condition monitoring systems for medium and slow speed diesel propulsion systems...