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Sample records for vibdv-infected bursa tlr7

  1. The Processed Amino-Terminal Fragment of Human TLR7 Acts as a Chaperone To Direct Human TLR7 into Endosomes

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    Shepherd, Dawn; Booth, Sarah; Waithe, Dominic; Reis e Sousa, Caetano

    2015-01-01

    TLR7 mediates innate immune responses to viral RNA in endocytic compartments. Mouse and human (h)TLR7 undergo proteolytic cleavage, resulting in the generation of a C-terminal fragment that accumulates in endosomes and associates with the signaling adaptor MyD88 upon receptor triggering by TLR7 agonists. Although mouse TLR7 is cleaved in endosomes by acidic proteases, hTLR7 processing can occur at neutral pH throughout the secretory pathway through the activity of furin-like proprotein convertases. However, the mechanisms by which cleaved hTLR7 reaches the endosomal compartment remain unclear. In this study, we demonstrate that, after hTLR7 proteolytic processing, the liberated amino (N)-terminal fragment remains bound to the C terminus through disulfide bonds and provides key trafficking information that ensures correct delivery of the complex to endosomal compartments. In the absence of the N-terminal fragment, the C-terminal fragment is redirected to the cell surface, where it is functionally inactive. Our data reveal a novel role for the N terminus of hTLR7 as a molecular chaperone that provides processed hTLR7 with the correct targeting instructions to reach the endosomal compartment, hence ensuring its biological activity and preventing inadvertent cell surface responses to self-RNA. PMID:25917086

  2. The TIR-domain containing adaptor TRAM is required for TLR7 mediated RANTES production.

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    Enda Shevlin

    Full Text Available Toll-like receptor 7 (TLR7 plays a vital role in the immune response to ssRNA viruses such as human rhinovirus (HRV and Influenza, against which there are currently no treatments or vaccines with long term efficacy available. Clearly, a more comprehensive understanding of the TLR7 signaling axis will contribute to its molecular targeting. TRIF related adaptor molecule (TRAM plays a vital role in TLR4 signaling by recruiting TRIF to TLR4, followed by endosomal trafficking of the complex and initiation of IRF3 dependent type I interferon production as well as NF-κB dependent pro-inflammatory cytokine production. Towards understanding the molecular mechanisms that regulate TLR7 functionality, we found that TRAM(-/- murine macrophages exhibited a transcriptional and translational impairment in TLR7 mediated RANTES, but not TNFα, production. Suppression of TRAM expression in human macrophages also resulted in an impairment in TLR7 mediated CCL5 and IFN-β, but not TNFα, gene induction. Furthermore, suppression of endogenous human TRAM expression in human macrophages significantly impaired RV16 induced CCL5 and IFNβ, but not TNFα gene induction. Additionally, TRAM-G2A dose-dependently inhibited TLR7 mediated activation of CCL5, IFNβ and IFNα reporter genes. TLR7-mediated phosphorylation and nuclear translocation of IRF3 was impaired in TRAM(-/- cells. Finally, co-immunoprecipitation studies indicated that TRAM physically interacts with MyD88 upon TLR7 stimulation, but not under basal conditions. Our results clearly demonstrate that TRAM plays a, hitherto unappreciated, role in TLR7 signaling through a novel signaling axis containing, but not limited to, MyD88, TRAM and IRF3 towards the activation of anti-viral immunity.

  3. Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes.

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    Li, Xiaobing; Saitoh, Shin-Ichiroh; Shibata, Takuma; Tanimura, Natsuko; Fukui, Ryutaro; Miyake, Kensuke

    2015-02-01

    Toll-like receptor 7 (TLR7) and TLR9 sense microbial single-stranded RNA (ssRNA) and ssDNA in endolysosomes. Nucleic acid (NA)-sensing in endolysosomes is thought to be important for avoiding TLR7/9 responses to self-derived NAs. Aberrant self-derived NA transportation to endolysosomes predisposes to autoimmune diseases. To restrict NA-sensing in endolysosomes, TLR7/9 trafficking is tightly controlled by a multiple transmembrane protein Unc93B1. In contrast to TLR7/9 trafficking, little is known about a mechanism underlying NA transportation. We here show that Mucolipin 1 (Mcoln1), a member of the transient receptor potential (TRP) cation channel gene family, has an important role in ssRNA trafficking into lysosomes. Mcoln1(-/-) dendritic cells (DCs) showed impaired TLR7 responses to ssRNA. A mucolipin agonist specifically enhanced TLR7 responses to ssRNAs. The channel activity of Mcoln1 is activated by a phospholipid phosphatidylinositol (3,5) bisphosphate (PtdIns(3,5)P2), which is generated by a class III lipid kinase PIKfyve. A PIKfyve inhibitor completely inhibited TLR7 responses to ssRNA in DCs. Confocal analyses showed that ssRNA transportation to lysosomes in DCs was impaired by PIKfyve inhibitor as well as by the lack of Mcoln1. Transportation of TLR9 ligands was also impaired by the PIKfyve inhibitor. These results demonstrate that the PtdIns(3,5)P2-Mcoln1 axis has an important role in ssRNA transportation into lysosomes in DCs. © The Japanese Society for Immunology. 2014. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  4. Structure Based Modeling of Small Molecules Binding to the TLR7 by Atomistic Level Simulations

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    Francesco Gentile

    2015-05-01

    Full Text Available Toll-Like Receptors (TLR are a large family of proteins involved in the immune system response. Both the activation and the inhibition of these receptors can have positive effects on several diseases, including viral pathologies and cancer, therefore prompting the development of new compounds. In order to provide new indications for the design of Toll-Like Receptor 7 (TLR7-targeting drugs, the mechanism of interaction between the TLR7 and two important classes of agonists (imidazoquinoline and adenine derivatives was investigated through docking and Molecular Dynamics simulations. To perform the computational analysis, a new model for the dimeric form of the receptors was necessary and therefore created. Qualitative and quantitative differences between agonists and inactive compounds were determined. The in silico results were compared with previous experimental observations and employed to define the ligand binding mechanism of TLR7.

  5. Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders

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    Møller-Larsen, Steffen; Nyegaard, Mette; Haagerup, Annette

    2008-01-01

    the TLR7 and TLR8 genes. METHODS: We investigated the involvement of TLR7 and TLR8 in the aetiology of asthma and related disorders by a family based association analysis of two independently ascertained family samples comprising 540 and 424 individuals from 135 and 100 families, respectively. Ten...

  6. A Novel Interaction Between the TLR7 and a Colchicine Derivative Revealed Through a Computational and Experimental Study

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    Francesco Gentile

    2018-02-01

    Full Text Available The Toll-Like Receptor 7 (TLR7 is an endosomal membrane receptor involved in the innate immune system response. Its best-known small molecule activators are imidazoquinoline derivatives such as imiquimod (R-837 and resiquimod (R-848. Recently, an interaction between R-837 and the colchicine binding site of tubulin was reported. To investigate the possibility of an interaction between structural analogues of colchicine and the TLR7, a recent computational model for the dimeric form of the TLR7 receptor was used to determine a possible interaction with a colchicine derivative called CR42-24, active as a tubulin polymerization inhibitor. The estimated values of the binding energy of this molecule with respect to the TLR7 receptor were comparable to the energies of known binders as reported in a previous study. The binding to the TLR7 was further assessed by introducing genetic transformations in the TLR7 gene in cancer cell lines and exposing them to the compound. A negative shift of the IC50 value in terms of cell growth was observed in cell lines carrying the mutated TLR7 gene. The reported study suggests a possible interaction between TLR7 and a colchicine derivative, which can be explored for rational design of new drugs acting on this receptor by using a colchicine scaffold for additional modifications.

  7. Poly-thymidine oligonucleotides mediate activation of murine glial cells primarily through TLR7, not TLR8.

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    Min Du

    Full Text Available The functional role of murine TLR8 in the inflammatory response of the central nervous system (CNS remains unclear. Murine TLR8 does not appear to respond to human TLR7/8 agonists, due to a five amino acid deletion in the ectodomain. However, recent studies have suggested that murine TLR8 may be stimulated by alternate ligands, which include vaccinia virus DNA, phosphothioate oligodeoxynucleotides (ODNs or the combination of phosphothioate poly-thymidine oligonucleotides (pT-ODNs with TLR7/8 agonists. In the current study, we analyzed the ability of pT-ODNs to induce activation of murine glial cells in the presence or absence of TLR7/8 agonists. We found that TLR7/8 agonists induced the expression of glial cell activation markers and induced the production of multiple proinflammatory cytokines and chemokines in mixed glial cultures. In contrast, pT-ODNs alone induced only low level expression of two cytokines, CCL2 and CXCL10. The combination of pT-ODNs along with TLR7/8 agonists induced a synergistic response with substantially higher levels of proinflammatory cytokines and chemokines compared to CL075. This enhancement was not due to cellular uptake of the agonist, indicating that the pT-ODN enhancement of cytokine responses was due to effects on an intracellular process. Interestingly, this response was also not due to synergistic stimulation of both TLR7 and TLR8, as the loss of TLR7 abolished the activation of glial cells and cytokine production. Thus, pT-ODNs act in synergy with TLR7/8 agonists to induce strong TLR7-dependent cytokine production in glial cells, suggesting that the combination of pT-ODNs with TLR7 agonists may be a useful mechanism to induce pronounced glial activation in the CNS.

  8. Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system.

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    Tomoko Hayashi

    Full Text Available The Toll-like receptors (TLR have been advocated as attractive therapeutic targets because TLR signaling plays dual roles in initiating adaptive immune responses and perpetuating inflammation. Paradoxically, repeated stimulation of bone marrow mononuclear cells with a synthetic TLR7 ligand 9-benzyl-8-hydroxy-2-(2-methoxyethoxy adenine (called 1V136 leads to subsequent TLR hyporesponsiveness. Further studies on the mechanism of action of this pharmacologic agent demonstrated that the TLR7 ligand treatment depressed dendritic cell activation, but did not directly affect T cell function. To verify this mechanism, we utilized experimental allergic encephalitis (EAE as an in vivo T cell dependent autoimmune model. Drug treated SJL/J mice immunized with proteolipid protein (PLP(139-151 peptide had attenuated disease severity, reduced accumulation of mononuclear cells in the central nervous system (CNS, and limited demyelination, without any apparent systemic toxicity. Splenic T cells from treated mice produced less cytokines upon antigenic rechallenge. In the spinal cords of 1V136-treated EAE mice, the expression of chemoattractants was also reduced, suggesting innate immune cell hyposensitization in the CNS. Indeed, systemic 1V136 did penetrate the CNS. These experiments indicated that repeated doses of a TLR7 ligand may desensitize dendritic cells in lymphoid organs, leading to diminished T cell responses. This treatment strategy might be a new modality to treat T cell mediated autoimmune diseases.

  9. 2'-O-methyl-modified RNAs act as TLR7 antagonists.

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    Robbins, Marjorie; Judge, Adam; Liang, Lisa; McClintock, Kevin; Yaworski, Ed; MacLachlan, Ian

    2007-09-01

    RNA molecules such as single-stranded RNA (ssRNA) and small interfering RNA (siRNA) duplexes induce Toll-like receptor (TLR)-mediated immune stimulation after intracellular delivery. We have previously shown that selective incorporation of 2'-O-methyl (2'OMe) residues into siRNA abrogates cytokine production without reduction of gene silencing activity. Here we show that 2'OMe-modified RNA acts as a potent inhibitor of RNA-mediated cytokine induction in both human and murine systems. This activity does not require the direct incorporation of 2'OMe nucleotides into the immunostimulatory RNA or that the 2'OMe nucleotide-containing RNA be annealed as a complementary strand to form a duplex. Our results indicate that 2'OMe RNA acts as a potent antagonist of immunostimulatory RNA. We further show that 2'OMe RNA is able significantly to reduce both interferon-alpha (IFN-alpha) and interleukin-6 (IL-6) induction by the small-molecule TLR7 agonist loxoribine in human peripheral blood mononuclear cells (human PBMCs), in murine Flt3L dendritic cells (Flt3L DCs), and in vivo in mice. These results indicate that 2'OMe-modified RNA may have utility as an inhibitor of TLR7 with potential applications in the treatment of inflammatory and autoimmune diseases that involve TLR7-mediated immune stimulation.

  10. Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7.

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    Coleman, Leon G; Zou, Jian; Crews, Fulton T

    2017-01-25

    Toll-like receptor (TLR) signaling is emerging as an important component of neurodegeneration. TLR7 senses viral RNA and certain endogenous miRNAs to initiate innate immune responses leading to neurodegeneration. Alcoholism is associated with hippocampal degeneration, with preclinical studies linking ethanol-induced neurodegeneration with central innate immune induction and TLR activation. The endogenous miRNA let-7b binds TLR7 to cause neurodegeneration. TLR7 and other immune markers were assessed in postmortem human hippocampal tissue that was obtained from the New South Wales Tissue Bank. Rat hippocampal-entorhinal cortex (HEC) slice culture was used to assess specific effects of ethanol on TLR7, let-7b, and microvesicles. We report here that hippocampal tissue from postmortem human alcoholic brains shows increased expression of TLR7 and increased microglial activation. Using HEC slice culture, we found that ethanol induces TLR7 and let-7b expression. Ethanol caused TLR7-associated neuroimmune gene induction and initiated the release let-7b in microvesicles (MVs), enhancing TLR7-mediated neurotoxicity. Further, ethanol increased let-7b binding to the danger signaling molecule high mobility group box-1 (HMGB1) in MVs, while reducing let-7 binding to classical chaperone protein argonaute (Ago2). Flow cytometric analysis of MVs from HEC media and analysis of MVs from brain cell culture lines found that microglia were the primary source of let-7b and HMGB1-containing MVs. Our results identify that ethanol induces neuroimmune pathology involving the release of let-7b/HMGB1 complexes in microglia-derived microvesicles. This contributes to hippocampal neurodegeneration and may play a role in the pathology of alcoholism.

  11. The TLR7 agonist Imiquimod promote the immunogenicity of msenchymal stem cells

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    Li Zhang

    2015-01-01

    Full Text Available BACKGROUND: Mesenchymal stem cells (MSCs are considered the best candidate in stem cells therapy due to their multipotent differentiation ability, low expression of co-stimulatory molecules (CD80, CD86, CD34 and HLA-II and immunosuppression effects on in vivo immune responses. MSCs were now widely used in clinical trials but received no encourage results. The major problem was the fate of engrafted MSCs in vivo could not be defined. Some studies indicated that MSCs could induce immune response and result in the damage and rejection of MSCs. As toll like receptors (TLRs are important in inducing of immune responses, in this study we study the role of TLR7 in mediating the immune status of MSCs isolated from umbilical cord. RESULTS: Our results indicated that TLR7 agonist Imiquimod could increase the proliferation of PBMC isolated from healthy human volunteers and release of lactate dehydrogenase (LDH in supernatant from PBMC-UCMSCs co-culture system. Flow cytometry and quantitative PCR also confirmed the regulated expression of surface co-stimulatory molecules and pro-inflammatory genes (IL-6, IL-8, IL-12, TGF-β and TNF-α. And the down-regulation expression of stem cell markers also confirmed the loss of stemness of UCMSCs. We also found that the osteo-differentiation ability of UCMSCs was enhanced in the presence of Imiquimod. CONCLUSION: To our knowledge, this is the first report that activation of TLR7 pathway increases the immunogenicity of UCMSCs. Extensive researches have now been conducted to study whether the change of immune status will be help in tumor rejection based on the tumor-tropism of MSCs.

  12. Association of TLR7 variants with AIDS-like disease and AIDS vaccine efficacy in rhesus macaques.

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    Roman A Siddiqui

    Full Text Available In HIV infection, TLR7-triggered IFN-α production exerts a direct antiviral effect through the inhibition of viral replication, but may also be involved in immune pathogenesis leading to AIDS. TLR7 could also be an important mediator of vaccine efficacy. In this study, we analyzed polymorphisms in the X-linked TLR7 gene in the rhesus macaque model of AIDS. Upon resequencing of the TLR7 gene in 36 rhesus macaques of Indian origin, 12 polymorphic sites were detected. Next, we identified three tightly linked single nucleotide polymorphisms (SNP as being associated with survival time. Genotyping of 119 untreated, simian immunodeficiency virus (SIV-infected male rhesus macaques, including an 'MHC adjusted' subset, revealed that the three TLR7 SNPs are also significantly associated with set-point viral load. Surprisingly, this effect was not observed in 72 immunized SIV-infected male monkeys. We hypothesize (i that SNP c.13G>A in the leader peptide is causative for the observed genotype-phenotype association and that (ii the underlying mechanism is related to RNA secondary structure formation. Therefore, we investigated a fourth SNP (c.-17C>T, located 17 bp upstream of the ATG translation initiation codon, that is also potentially capable of influencing RNA structure. In c.13A carriers, neither set-point viral load nor survival time were related to the c.-17C>T genotype. In c.13G carriers, by contrast, the c.-17C allele was significantly associated with prolonged survival. Again, no such association was detected among immunized SIV-infected macaques. Our results highlight the dual role of TLR7 in immunodeficiency virus infection and vaccination and imply that it may be important to control human AIDS vaccine trials, not only for MHC genotype, but also for TLR7 genotype.

  13. Activation of autoreactive B cells by endogenous TLR7 and TLR3 RNA ligands.

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    Green, Nathaniel M; Moody, Krishna-Sulayman; Debatis, Michelle; Marshak-Rothstein, Ann

    2012-11-16

    The key step in the activation of autoreactive B cells is the internalization of nucleic acid containing ligands and delivery of these ligands to the Toll-like Receptor (TLR) containing endolysosomal compartment. Ribonucleoproteins represent a large fraction of autoantigens in systemic autoimmune diseases. Here we demonstrate that many uridine-rich mammalian RNA sequences associated with common autoantigens effectively activate autoreactive B cells. Priming with type I IFN increased the magnitude of activation, and the range of which RNAs were stimulatory. A subset of RNAs that contain a high degree of self-complementarity also activated B cells through TLR3. For the RNA sequences that activated predominantly through TLR7, the activation is proportional to uridine-content, and more precisely defined by the frequency of specific uridine-containing motifs. These results identify parameters that define specific mammalian RNAs as ligands for TLRs.

  14. Low TLR7 gene expression in atherosclerotic plaques is associated with major adverse cardio- and cerebrovascular events

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    Karadimou, Glykeria; Folkersen, Lasse; Berg, Martin

    2016-01-01

    Aims: Processes in the development of atherosclerotic lesions can lead to plaque rupture or erosion, which can in turn elicit myocardial infarction or ischaemic stroke. The aims of this study were to determine whether Toll-like receptor 7 (TLR7) gene expression levels influence patient outcome an...

  15. Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis

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    Greiff Lennart

    2012-06-01

    Full Text Available Abstract Background Interactions between Th1 and Th2 immune responses are of importance to the onset and development of allergic disorders. A Toll-like receptor 7 agonist such as AZD8848 may have potential as a treatment for allergic airway disease by skewing the immune system away from a Th2 profile. Objective To evaluate the efficacy and safety of intranasal AZD8848. Methods In a placebo-controlled single ascending dose study, AZD8848 (0.3-600 μg was given intranasally to 48 healthy subjects and 12 patients with allergic rhinitis (NCT00688779. In a placebo-controlled repeat challenge/treatment study, AZD8848 (30 and 60 μg was given once weekly for five weeks to 74 patients with allergic rhinitis out of season: starting 24 hours after the final dose, daily allergen challenges were given for seven days (NCT00770003. Safety, tolerability, pharmacokinetics, and biomarkers were monitored. During the allergen challenge series, nasal symptoms and lavage fluid levels of tryptase and α2-macroglobulin, reflecting mast cell activity and plasma exudation, were monitored. Results AZD8848 produced reversible blood lymphocyte reductions and dose-dependent flu-like symptoms: 30–100 μg produced consistent yet tolerable effects. Plasma interleukin-1 receptor antagonist was elevated after administration of AZD8848, reflecting interferon production secondary to TLR7 stimulation. At repeat challenge/treatment, AZD8848 reduced nasal symptoms recorded ten minutes after allergen challenge up to eight days after the final dose. Tryptase and α2-macroglobulin were also reduced by AZD8848. Conclusions Repeated intranasal stimulation of Toll-like receptor 7 by AZD8848 was safe and produced a sustained reduction in the responsiveness to allergen in allergic rhinitis. Trial registration NCT00688779 and NCT00770003 as indicated above.

  16. Imaging of bursae around the shoulder joint

    International Nuclear Information System (INIS)

    Bureau, N.J.; Dussault, R.G.; Keats, T.E.

    1996-01-01

    The authors present a review of the anatomy of the major bursae around the shoulder joint and discuss the use of the different imaging modalities which demonstrate their radiologic features. The calcified subacromial-subdeltoid bursa has a characteristic appearance on plain radiographs. When inflamed it can be visualized by ultrasound and magnetic resonance imaging. Calcific bursitis may involve the subcoracoid bursa. This bursa may mimic adhesive capsulitis of the shoulder or complete rotator cuff tear when injected inadvertently during shoulder arthrography. Less well known are three coracoclavicular ligament bursae. These are also subject to calcific bursitis and have a typical radiologic appearance. (orig.). With 6 figs

  17. Imaging of bursae around the shoulder joint

    Energy Technology Data Exchange (ETDEWEB)

    Bureau, N.J. [Department of Radiology, Hotel-Dieu de Montreal Hospital, Montreal, Quebec (Canada); Dussault, R.G. [Department of Radiology, Health Sciences Center, University of Virginia, Charlottesville, Virginia (United States); Keats, T.E. [Department of Radiology, Health Sciences Center, University of Virginia, Charlottesville, Virginia (United States)

    1996-08-01

    The authors present a review of the anatomy of the major bursae around the shoulder joint and discuss the use of the different imaging modalities which demonstrate their radiologic features. The calcified subacromial-subdeltoid bursa has a characteristic appearance on plain radiographs. When inflamed it can be visualized by ultrasound and magnetic resonance imaging. Calcific bursitis may involve the subcoracoid bursa. This bursa may mimic adhesive capsulitis of the shoulder or complete rotator cuff tear when injected inadvertently during shoulder arthrography. Less well known are three coracoclavicular ligament bursae. These are also subject to calcific bursitis and have a typical radiologic appearance. (orig.). With 6 figs.

  18. Interferon-alpha suppressed granulocyte colony stimulating factor production is reversed by CL097, a TLR7/8 agonist.

    LENUS (Irish Health Repository)

    Tajuddin, Tariq

    2012-02-01

    BACKGROUND AND AIM: Neutropenia, a major side-effect of interferon-alpha (IFN-alpha) therapy can be effectively treated by the recombinant form of granulocyte colony stimulating factor (G-CSF), an important growth factor for neutrophils. We hypothesized that IFN-alpha might suppress G-CSF production by peripheral blood mononuclear cells (PBMCs), contributing to the development of neutropenia, and that a toll-like receptor (TLR) agonist might overcome this suppression. METHODS: Fifty-five patients who were receiving IFN-alpha\\/ribavirin combination therapy for chronic hepatitis C virus (HCV) infection were recruited. Absolute neutrophil counts (ANC), monocyte counts and treatment outcome data were recorded. G-CSF levels in the supernatants of PBMCs isolated from the patients and healthy controls were assessed by enzyme-linked immunosorbent assay following 18 h of culture in the absence or presence of IFN- alpha or the TLR7\\/8 agonist, CL097. RESULTS: Therapeutic IFN-alpha caused a significant reduction in neutrophil counts in all patients, with 15 patients requiring therapeutic G-CSF. The reduction in ANC over the course of IFN-alpha treatment was paralleled by a decrease in the ability of PBMCs to produce G-CSF. In vitro G-CSF production by PBMCs was suppressed in the presence of IFN-alpha; however, co-incubation with a TLR7\\/8 agonist significantly enhanced G-CSF secretion by cells obtained both from HCV patients and healthy controls. CONCLUSIONS: Suppressed G-CSF production in the presence of IFN-alpha may contribute to IFN-alpha-induced neutropenia. However, a TLR7\\/8 agonist elicits G-CSF secretion even in the presence of IFN-alpha, suggesting a possible therapeutic role for TLR agonists in treatment of IFN-alpha-induced neutropenia.

  19. Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.

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    Khan, Adnan R; Amu, Sylvie; Saunders, Sean P; Hams, Emily; Blackshields, Gordon; Leonard, Martin O; Weaver, Casey T; Sparwasser, Tim; Sheils, Orla; Fallon, Padraic G

    2015-06-01

    B cells have been described as having the capacity to regulate cellular immune responses and suppress inflammatory processes. One such regulatory B-cell population is defined as IL-10-producing CD19(+) CD1d(hi) cells. Previous work has identified an expansion of these cells in mice infected with the helminth, Schistosoma mansoni. Here, microarray analysis of CD19(+) CD1d(hi) B cells from mice infected with S. mansoni demonstrated significantly increased Tlr7 expression, while CD19(+) CD1d(hi) B cells from uninfected mice also demonstrated elevated Tlr7 expression. Using IL-10 reporter, Il10(-/-) and Tlr7(-/-) mice, we formally demonstrate that TLR7 ligation of CD19(+) CD1d(hi) B cells increases their capacity to produce IL-10. In a mouse model of allergic lung inflammation, the adoptive transfer of TLR7-elicited CD19(+) CD1d(hi) B cells reduced airway inflammation and associated airway hyperresponsiveness. Using DEREG mice to deplete FoxP3(+) T regulatory cells in allergen-sensitized mice, we show that that TLR7-elicited CD19(+) CD1d(hi) B cells suppress airway hyperresponsiveness via a T regulatory cell dependent mechanism. These studies identify that TLR7 stimulation leads to the expansion of IL-10-producing CD19(+) CD1d(hi) B cells, which can suppress allergic lung inflammation via T regulatory cells. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Identification, characterization and genetic mapping of TLR7, TLR8a1 and TLR8a2 genes in rainbow trout (Oncorhynchus mykiss)

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    Palti, Yniv; Gahr, Scott A.; Purcell, Maureen K.; Hadidi, Sima; Rexroad, Caird E.; Wiens, Gregory A.

    2010-01-01

    Induction of the innate immune pathways is critical for early anti-viral defense but there is limited understanding of how teleost fish recognize viral molecules and activate these pathways. In mammals, Toll-like receptors (TLR) 7 and 8 bind single-stranded RNA of viral origin and are activated by synthetic anti-viral imidazoquinoline compounds. Herein, we identify and describe the rainbow trout (Oncorhynchus mykiss) TLR7 and TLR8 gene orthologs and their mRNA expression. Two TLR7/8 loci were identified from a rainbow trout bacterial artificial chromosome (BAC) library using DNA fingerprinting and genetic linkage analyses. Direct sequencing of two representative BACs revealed intact omTLR7 and omTLR8a1 open reading frames (ORFs) located on chromosome 3 and a second locus on chromosome 22 that contains an omTLR8a2 ORF and a putative TLR7 pseudogene. We used the omTLR8a1/2 nomenclature for the two trout TLR8 genes as phylogenetic analysis revealed that they and all the other teleost TLR8 genes sequenced to date are similar to the zebrafish TLR8a, but are distinct from the zebrafish TLR8b. The duplicated trout loci exhibit conserved synteny with other fish genomes extending beyond the tandem of TLR7/8 genes. The trout TLR7 and 8a1/2 genes are composed of a single large exon similar to all other described TLR7/8 genes. The omTLR7 ORF is predicted to encode a 1049 amino acid (aa) protein with 84% similarity to the Fugu TLR7 and a conserved pattern of predicted leucine-rich repeats (LRR). The omTLR8a1 and omTLR8a2 are predicted to encode 1035- and 1034-aa proteins, respectively, and have 86% similarity to each other. omTLR8a1 is likely the ortholog of the only Atlantic salmon TLR8 gene described to date as they have 95% aa sequence similarity. The tissue expression profiles of omTLR7, omTLR8a1 and omTLR8a2 in healthy trout were highest in spleen tissue followed by anterior and then posterior kidney tissues. Rainbow trout anterior kidney leukocytes produced elevated

  1. IN VITRO INTERACTION OF INFLUENZA VIRUS A(H1N1pdm09 WITH MONOCYTIC MACROPHAGES: INDIVIDUAL RESPONSES OF TLR7 AND RIG1 RECEPTOR GENES

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    T. M. Sokolova

    2017-01-01

    Full Text Available In vitro differentiation of donor blood monocytes to macrophages (Mph following GM-CSF treatment was accompanied by a significant increase in the levels of gene transcription signaling receptors TLR7 or RIG1. The levels of intracellular viral RNA (M1 gene in Mph remained high upon infection by influenza virus A H1N1pdm (Moscow 2009 for 24-96 hours. The innate immunity reactions caused by influenza virus show individual features: they are decreased in Mph from donor 1 which had initially high level of endosomal TLR7 gene activity, and it increased by influenza virus in MPh from donor 2 who had a very low level of TLR7 gene expression. The influenza H1N1pdm virus weakly stimulated expression of gene RIG1 and production of inflammatory cytokines in Mf in donor 1. The differences may be connected with individual sensitivity of the donors to influenza infection.

  2. Effects of Gui Zhi Ma Huang Ge Ban Tang on the TLR7 Pathway in Influenza Virus Infected Mouse Lungs in a Cold Environment.

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    Qin, Hong-Qiong; Shi, Shan-Shan; Fu, Ying-Jie; Yan, Yu-Qi; Wu, Sha; Tang, Xiao-Long; Chen, Xiao-Yin; Hou, Guang-Hui; Jiang, Zhen-You

    2018-01-01

    We wished to investigate the effects of the traditional Chinese medicine Gui Zhi Ma Huang Ge Ban Tang on controlling influenza A virus (IAV) infection and improving inflammation in mouse lungs. Mice were maintained in normal and cold environments and infected with IAV by intranasal application, respectively. Real-time quantitative polymerase chain reaction was used to measure mRNA expression of TLR7, myeloid differentiation primary response 88 (MyD88), and nuclear factor-kappa B (NF- κ B)p65 in the TLR7 signaling pathway and virus replication in lungs. Western blotting was used to measure expression levels of TLR7, MyD88, and NF- κ B p65 proteins. Flow cytometry was used to detect the proportion of T-helper (Th)1/Th2 and Th17/T-regulatory (Treg) cells. Application of Gui Zhi Ma Huang Ge Ban Tang in influenza-infected mice in a cold environment showed (i) downregulation of TLR7, MyD88, and NF- κ Bp65; (ii) inhibition of transcriptional activities of promoters coding for TLR7, MyD88, and NF- κ Bp65; (iii) reduction in the proportion of Th1/Th2 and Th17/Treg cells. Gui Zhi Ma Huang Ge Ban Tang had a good therapeutic effect on mice infected with IAV, especially in the cold environment. It could reduce lung inflammation in mice significantly and elicit an anti-influenza effect by downregulating expression of the key factors in TLR7 signaling pathway.

  3. Immunizations with hepatitis B viral antigens and a TLR7/8 agonist adjuvant induce antigen-specific immune responses in HBV-transgenic mice

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    Ying Wang

    2014-12-01

    Conclusions: Immunization with CL097-conjugated HBV-Ag reversed immune tolerance in HBV-Tg mice and induced antigen-specific immune responses. TLR7/8 agonists appear to be potent adjuvants for the induction of antigen-specific Th1 responses in an immune tolerant state.

  4. Imaging of nasopharyngeal cysts and bursae

    International Nuclear Information System (INIS)

    Ben Salem, D.; Ricolfi, Frederic; Duvillard, Christian; Ballester, Michel; Assous, Dorothee; Krause, Denis

    2006-01-01

    Cysts and bursae of the nasopharynx are uncommon and seldom symptomatic when compared with malignant tumors of this region. However, it is noteworthy that in the presence of symptoms, a good knowledge of their radiological appearance is useful to establish the correct diagnosis. Cysts of Rathke's pouch, pharyngeal bursa of Luschka, Tornwaldt's cysts, retentional cysts of the seromucinous glands, oncocytic cysts, intra-adenoid cysts, branchial cysts, prevertebral or retropharyngeal abscess and pseudocysts of the nasopharynx will be discussed in this paper. (orig.)

  5. Stimulation of TLR7 with Gardiquimod Enhances Protection and Activation of Immune Cells from γ-Irradiation Exposure

    International Nuclear Information System (INIS)

    Yang, Young-Mi; Bang, Ji-Young; Lee, Suhl-Hyeong; Moon, Tae-Min; Jung, Yu-Jin

    2007-01-01

    Radiotherapy for cancer patients is based on the radiation-induced cell death, but high dose of radiation is able to cause break of immune system. Thus, protection of immune cells from radiation damage is required to enhance the efficiency and reduce the harmful side effects during cancer radiotherapy. Toll-like receptors (TLRs) are important not only in initiating innate immunity against microbial infection, but also inducing Th1-mediated immunity with producing cytokines and chemokines. Cell stimulation via TLRs leads to downstream activation of NF-kB and other transcription factors. Consequently, several genes encoding mediators and effector molecules of the innate as well as the adaptive immune response are transcribed. There are several previous findings that activated immune cells via TLR9 inducing pathways are resistant to chemical or radiation exposure. But it is not clear that the other TLRs also have the same abilities to protect immune cells against cellular damages including γ-irradiation. This research was performed to evaluate protective effect of immune cells from γ-irradiation through TLR-7 activation pathway

  6. TLR7/TLR8 Activation Restores Defective Cytokine Secretion by Myeloid Dendritic Cells but Not by Plasmacytoid Dendritic Cells in HIV-Infected Pregnant Women and Newborns.

    Directory of Open Access Journals (Sweden)

    Elaine Cristina Cardoso

    Full Text Available Mother-to-child transmission (MTCT of HIV-1 has been significantly reduced with the use of antiretroviral therapies, resulting in an increased number of HIV-exposed uninfected infants. The consequences of HIV infection on the innate immune system of both mother-newborn are not well understood. In this study, we analyzed peripheral blood and umbilical cord blood (CB collected from HIV-1-infected and uninfected pregnant women. We measured TNF-α, IL-10 and IFN-α secretion after the stimulation of the cells with agonists of both extracellular Toll-like receptors (TLRs (TLR2, TLR4 and TLR5 and intracellular TLRs (TLR7, TLR7/8 and TLR9. Moreover, as an indicator of the innate immune response, we evaluated the responsiveness of myeloid dendritic cells (mDCs and plasmacytoid DCs (pDCs to TLRs that are associated with the antiviral response. Our results showed that peripheral blood mononuclear cells (PBMCs from HIV-1-infected mothers and CB were defective in TNF-α production after activation by TLR2, TLR5, TLR3 and TLR7. However, the TNF-α response was preserved after TLR7/8 (CL097 stimulation, mainly in the neonatal cells. Furthermore, only CL097 activation was able to induce IL-10 and IFN-α secretion in both maternal and CB cells in the infected group. An increase in IFN-α secretion was observed in CL097-treated CB from HIV-infected mothers compared with control mothers. The effectiveness of CL097 stimulation was confirmed by observation of similar mRNA levels of interferon regulatory factor-7 (IRF-7, IFN-α and TNF-α in PBMCs of both groups. The function of both mDCs and pDCs was markedly compromised in the HIV-infected group, and although TLR7/TLR8 activation overcame the impairment in TNF-α secretion by mDCs, such stimulation was unable to reverse the dysfunctional type I IFN response by pDCs in the HIV-infected samples. Our findings highlight the dysfunction of innate immunity in HIV-infected mother-newborn pairs. The activation of the TLR7

  7. TLR7/TLR8 Activation Restores Defective Cytokine Secretion by Myeloid Dendritic Cells but Not by Plasmacytoid Dendritic Cells in HIV-Infected Pregnant Women and Newborns.

    Science.gov (United States)

    Cardoso, Elaine Cristina; Pereira, Nátalli Zanete; Mitsunari, Gabrielle Eimi; Oliveira, Luanda Mara da Silva; Ruocco, Rosa Maria S A; Francisco, Rossana Pulcineli Vieira; Zugaib, Marcelo; da Silva Duarte, Alberto José; Sato, Maria Notomi

    2013-01-01

    Mother-to-child transmission (MTCT) of HIV-1 has been significantly reduced with the use of antiretroviral therapies, resulting in an increased number of HIV-exposed uninfected infants. The consequences of HIV infection on the innate immune system of both mother-newborn are not well understood. In this study, we analyzed peripheral blood and umbilical cord blood (CB) collected from HIV-1-infected and uninfected pregnant women. We measured TNF-α, IL-10 and IFN-α secretion after the stimulation of the cells with agonists of both extracellular Toll-like receptors (TLRs) (TLR2, TLR4 and TLR5) and intracellular TLRs (TLR7, TLR7/8 and TLR9). Moreover, as an indicator of the innate immune response, we evaluated the responsiveness of myeloid dendritic cells (mDCs) and plasmacytoid DCs (pDCs) to TLRs that are associated with the antiviral response. Our results showed that peripheral blood mononuclear cells (PBMCs) from HIV-1-infected mothers and CB were defective in TNF-α production after activation by TLR2, TLR5, TLR3 and TLR7. However, the TNF-α response was preserved after TLR7/8 (CL097) stimulation, mainly in the neonatal cells. Furthermore, only CL097 activation was able to induce IL-10 and IFN-α secretion in both maternal and CB cells in the infected group. An increase in IFN-α secretion was observed in CL097-treated CB from HIV-infected mothers compared with control mothers. The effectiveness of CL097 stimulation was confirmed by observation of similar mRNA levels of interferon regulatory factor-7 (IRF-7), IFN-α and TNF-α in PBMCs of both groups. The function of both mDCs and pDCs was markedly compromised in the HIV-infected group, and although TLR7/TLR8 activation overcame the impairment in TNF-α secretion by mDCs, such stimulation was unable to reverse the dysfunctional type I IFN response by pDCs in the HIV-infected samples. Our findings highlight the dysfunction of innate immunity in HIV-infected mother-newborn pairs. The activation of the TLR7/8 pathway

  8. Aging Impairs the Ability of Conventional Dendritic Cells to Cross-Prime CD8+ T Cells upon Stimulation with a TLR7 Ligand.

    Directory of Open Access Journals (Sweden)

    Estefanía R Zacca

    Full Text Available The aging process is accompanied by altered immune system functioning and an increased risk of infection. Dendritic cells (DCs are antigen-presenting cells that play a key role in both adaptive and innate immunity, but how aging affects DCs and their influence on immunity has not been thoroughly established. Here we examined the function of conventional DCs (cDCs in old mice after TLR7 stimulation, focusing on their ability to cross-prime CD8+ T cells. Using polyU, a synthetic ssRNA analog, as TLR7 ligand and OVA as an antigen (Ag model, we found that cDCs from old mice have a poor ability to stimulate a CD8+ T cell-mediated cytotoxic response. cDCs from old mice exhibit alterations in Ag-processing machinery and TLR7 activation. Remarkably, CD8α+ cDCs from old mice have an impaired ability to activate naïve CD8+ T cells and, moreover, a lower capacity to mature and to process exogenous Ag. Taken together, our results suggest that immunosenescence impacts cDC function, affecting the activation of naïve CD8+ T cells and the generation of effector cytotoxic T cells.

  9. Imaging of nasopharyngeal cysts and bursae

    Energy Technology Data Exchange (ETDEWEB)

    Ben Salem, D.; Ricolfi, Frederic [CHU DIJON, Service de Neuroradiologie et de Radiologie des Urgences, Dijon, Cedex (France); Duvillard, Christian; Ballester, Michel [CHU DIJON, Service d' ORL, Dijon, Cedex (France); Assous, Dorothee [CHU DIJON, Service d' Anatomie et de Cytologie Pathologiques Faculte de Medecine, Dijon, Cedex (France); Krause, Denis [CHU DIJON, Service d' Imagerie Diagnostique et Interventionnelle, Dijon, Cedex (France)

    2006-10-15

    Cysts and bursae of the nasopharynx are uncommon and seldom symptomatic when compared with malignant tumors of this region. However, it is noteworthy that in the presence of symptoms, a good knowledge of their radiological appearance is useful to establish the correct diagnosis. Cysts of Rathke's pouch, pharyngeal bursa of Luschka, Tornwaldt's cysts, retentional cysts of the seromucinous glands, oncocytic cysts, intra-adenoid cysts, branchial cysts, prevertebral or retropharyngeal abscess and pseudocysts of the nasopharynx will be discussed in this paper. (orig.)

  10. Enhanced Replication of Virulent Newcastle Disease Virus in Chicken Macrophages Is due to Polarized Activation of Cells by Inhibition of TLR7.

    Science.gov (United States)

    Zhang, Pingze; Ding, Zhuang; Liu, Xinxin; Chen, Yanyu; Li, Junjiao; Tao, Zhi; Fei, Yidong; Xue, Cong; Qian, Jing; Wang, Xueli; Li, Qingmei; Stoeger, Tobias; Chen, Jianjun; Bi, Yuhai; Yin, Renfu

    2018-01-01

    Newcastle disease (ND), caused by infections with virulent strains of Newcastle disease virus (NDV), is one of the most important infectious disease affecting wild, peridomestic, and domestic birds worldwide. Vaccines constructed from live, low-virulence (lentogenic) viruses are the most accepted prevention and control strategies for combating ND in poultry across the globe. Avian macrophages are one of the first cell lines of defense against microbial infection, responding to signals in the microenvironment. Although macrophages are considered to be one of the main target cells for NDV infection in vivo , very little is known about the ability of NDV to infect chicken macrophages, and virulence mechanisms of NDV as well as the polarized activation patterns of macrophages and correlation with viral infection and replication. In the present study, a cell culture model (chicken bone marrow macrophage cell line HD11) and three different virulence and genotypes of NDV (including class II virulent NA-1, class II lentogenic LaSota, and class I lentogenic F55) were used to solve the above underlying questions. Our data indicated that all three NDV strains had similar replication rates during the early stages of infection. Virulent NDV titers were shown to increase compared to the other lentogenic strains, and this growth was associated with a strong upregulation of both pro-inflammatory M1-like markers/cytokines and anti-inflammatory M2-like markers/cytokines in chicken macrophages. Virulent NDV was found to block toll-like receptor (TLR) 7 expression, inducing higher expression of type I interferons in chicken macrophages at the late stage of viral infection. Only virulent NDV replication can be inhibited by pretreatment with TLR7 ligand. Overall, this study demonstrated that virulent NDV activates a M1-/M2-like mixed polarized activation of chicken macrophages by inhibition of TLR7, resulting in enhanced replication compared to lentogenic viruses.

  11. Development of a novel severe triple allergen asthma model in mice which is resistant to dexamethasone and partially resistant to TLR7 and TLR9 agonist treatment.

    Directory of Open Access Journals (Sweden)

    Matthias J Duechs

    Full Text Available Severe asthma is characterised by persistent inflammation, hyperreactivity and remodeling of the airways. No efficient treatment is available, this is particularly the case for steroid resistant phenotypes. Our aim therefore was to develop a preclinical model showing characteristics of severe human asthma including steroid insensitivity. Mice were first sensitized with ovalbumin, extracts of cockroach or house dust mite followed by a challenge period of seven weeks. Further to this, an additional group of mice was sensitized with all three allergens and then challenged with allergen alternating weekly between allergens. All three allergens applied separately to the mice induced comparably strong Th2-type airway inflammation, airway hyperreactivity and airway remodeling, which was characterised by fibrosis and increased smooth muscle thickness. In contrast, application of all three allergens together resulted in a greater Th2 response and increased airway hyperreactivity and a stronger albeit not significant remodeling phenotype compared to using HDM or CRA. In this triple allergen model dexamethasone application, during the last 4 weeks of challenge, showed no suppressive effects on any of these parameters in this model. In contrast, both TLR7 agonist resiquimod and TLR9 agonist CpG-ODN reduced allergen-specific IgE, eosinophils, and collagen I in the lungs. The TLR9 agonist also reduced IL-4 and IL-5 whilst increasing IFN-γ and strongly IL-10 levels in the lungs, effects not seen with the TLR7 agonist. However, neither TLR agonist had any effect on airway hyperreactivity and airway smooth muscle mass. In conclusion we have developed a severe asthma model, which is steroid resistant and only partially sensitive to TLR7 and TLR9 agonist treatment. This model may be particular useful to test new potential therapeutics aiming at treating steroid resistant asthma in humans and investigating the underlying mechanisms responsible for steroid

  12. Src Family Kinases Regulate Interferon Regulatory Factor 1 K63 Ubiquitination following Activation by TLR7/8 Vaccine Adjuvant in Human Monocytes and B Cells

    Directory of Open Access Journals (Sweden)

    Lorenza Tulli

    2018-03-01

    Full Text Available Toll-like receptors (TLRs play a key role in the activation of innate immune cells, in which their engagement leads to production of cytokines and co-stimulatory molecules. TLRs signaling requires recruitment of toll/IL-1R (TIR domain-containing adaptors, such as MyD88 and/or TRIF, and leads to activation of several transcription factors, such as NF-κB, the AP1 complex, and various members of the interferon regulatory factor (IRF family, which in turn results in triggering of several cellular functions associated with these receptors. A role for Src family kinases (SFKs in this signaling pathway has also been established. Our work and that of others have shown that this type of kinases is activated following engagement of several TLRs, and that this event is essential for the initiation of specific downstream cellular response. In particular, we have previously demonstrated that activation of SFKs is required for balanced production of pro-inflammatory cytokines by monocyte-derived dendritic cells after stimulation with R848, an agonist of human TLRs 7/8. We also showed that TLR7/8 triggering leads to an increase in interferon regulatory factor 1 (IRF-1 protein levels and that this effect is abolished by inhibition of SFKs, suggesting a critical role of these kinases in IRF-1 regulation. In this study, we first confirmed the key role of SFKs in TLR7/8 signaling for cytokine production and accumulation of IRF-1 protein in monocytes and in B lymphocytes, two other type of antigen-presenting cells. Then, we demonstrate that TLR7 triggering leads to an increase of K63-linked ubiquitination of IRF-1, which is prevented by SFKs inhibition, suggesting a key role of these kinases in posttranslational regulation of IRF-1 in the immune cells. In order to understand the mechanism that links SFKs activation to IRF-1 K63-linked ubiquitination, we examined SFKs and IRF-1 possible interactors and proved that activation of SFKs is necessary for their

  13. Lipoma arborescens of the bicipitoradial bursa

    International Nuclear Information System (INIS)

    Kord Valeshabad, Ali; De la Vara, Dallas; Shamim, Ejaz; Xie, Karen L.; Alsadi, Alaa

    2018-01-01

    Lipoma arborescens (LA) is a rare, benign articular lesion that is most commonly found within the suprapatellar recess of the knee. An extremely rare case of LA involving unilateral bicipitoradial bursa is described in this study. A 58-year-old male presented with a superficial soft mass on the volar aspect of the left forearm. The magnetic resonance imaging (MRI) examination demonstrated a lobulated complex mass containing multiple frond-like fatty nodules, along the distal biceps tendon in the bicipitoradial bursa. Ultrasound-guided biopsy of the lesion confirmed the diagnosis of LA and patient was scheduled for surgical excision. Recognizing the characteristic imaging of LA, particularly on MRI, is essential for accurate pre-procedural diagnosis. (orig.)

  14. Traumatic lipohemobursa of the infrapatellar bursa

    Directory of Open Access Journals (Sweden)

    Segen Aklilu, MD

    2018-04-01

    Full Text Available Displaced fractures allow spillage of bone marrow and blood into the surrounding soft tissues. When the fracture is intra-articular, the spilled marrow contents may be contained by the associated joint capsule, resulting in a lipohemarthrosis. This is sometimes visible as a fat-fluid level on imaging. At the knee, the characteristic appearance of lipohemarthrosis within the suprapatellar recess signifies the presence of an intra-articular fracture that may otherwise not be radiographically apparent. We present a case in which an extra-articular proximal tibia fracture allowed spillage of marrow contents into the deep infrapatellar bursa, resulting in a lipohemobursa. The radiologic appearance mirrors the classic appearance of lipohemarthrosis with a fat-fluid level. Keywords: Lipohemobursa, Infrapatellar bursa

  15. Lipoma arborescens of the bicipitoradial bursa

    Energy Technology Data Exchange (ETDEWEB)

    Kord Valeshabad, Ali [University of Illinois, Department of Radiology, Chicago, IL (United States); University of Illinois, Division of Interventional Radiology, Chicago, IL (United States); De la Vara, Dallas; Shamim, Ejaz; Xie, Karen L. [University of Illinois, Department of Radiology, Chicago, IL (United States); Alsadi, Alaa [University of Illinois, Department of Pathology, Chicago, IL (United States)

    2018-04-15

    Lipoma arborescens (LA) is a rare, benign articular lesion that is most commonly found within the suprapatellar recess of the knee. An extremely rare case of LA involving unilateral bicipitoradial bursa is described in this study. A 58-year-old male presented with a superficial soft mass on the volar aspect of the left forearm. The magnetic resonance imaging (MRI) examination demonstrated a lobulated complex mass containing multiple frond-like fatty nodules, along the distal biceps tendon in the bicipitoradial bursa. Ultrasound-guided biopsy of the lesion confirmed the diagnosis of LA and patient was scheduled for surgical excision. Recognizing the characteristic imaging of LA, particularly on MRI, is essential for accurate pre-procedural diagnosis. (orig.)

  16. IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance

    Science.gov (United States)

    Patin, Emmanuel C.; Jones, Adam V.; Thompson, Aiysha; Clement, Mathew; Liao, Chia-Te; Griffiths, James S.; Wallace, Leah E.; Bryant, Clare E.; Lang, Roland; Rosenstiel, Philip; Humphreys, Ian R.; Taylor, Philip R.

    2016-01-01

    Candida spp. elicit cytokine production downstream of various pathogen recognition receptors, including C-type lectin-like receptors, TLRs, and nucleotide oligomerization domain (NOD)–like receptors. IL-12 family members IL-12p70 and IL-23 are important for host immunity against Candida spp. In this article, we show that IL-27, another IL-12 family member, is produced by myeloid cells in response to selected Candida spp. We demonstrate a novel mechanism for Candida parapsilosis–mediated induction of IL-27 in a TLR7-, MyD88-, and NOD2-dependent manner. Our data revealed that IFN-β is induced by C. parapsilosis, which in turn signals through the IFN-α/β receptor and STAT1/2 to induce IL-27. Moreover, IL-27R (WSX-1)–deficient mice systemically infected with C. parapsilosis displayed enhanced pathogen clearance compared with wild-type mice. This was associated with increased levels of proinflammatory cytokines in the serum and increased IFN-γ and IL-17 responses in the spleens of IL-27R–deficient mice. Thus, our data define a novel link between C. parapsilosis, TLR7, NOD2, IFN-β, and IL-27, and we have identified an important role for IL-27 in the immune response against C. parapsilosis. Overall, these findings demonstrate an important mechanism for the suppression of protective immune responses during infection with C. parapsilosis, which has potential relevance for infections with other fungal pathogens. PMID:27259855

  17. Defective bursa regeneration after irradiation of young thymectomized chickens

    International Nuclear Information System (INIS)

    Bhogal, B.S.; Chi, D.S.; Galton, J.E.; Bell, M.K.; Thorbecke, G.J.

    1984-01-01

    The ability of the bursa of Fabricius to regenerate after gamma-irradiation and bone marrow reconstitution was examined in chickens thymectomized (TX) immediately after hatching. Irradiation (2 X 500 R) 3 weeks after hatching was followed by impaired bursa regeneration, as judged both by bursa/body weight ratios and by bursa follicle development 3-6 weeks later in TX as compared to control birds. Germinal center formation in the spleen was deficient, and immune responses to sheep erythrocytes (SRBC) and B. abortus (BA) were moderately reduced in the TX as compared to control birds irradiated at 3 weeks but not in TX birds irradiated at 5 weeks of age

  18. Capsella bursa + pastoris (L. Med. - another weed resistant to Simazine?

    Directory of Open Access Journals (Sweden)

    Janusz Lipecki

    2014-01-01

    Full Text Available Biotypes of Capsella bursa-pastoris resistant to Simazine were found in orchards in the Lublin region in the years 1984-1986. This resistance was confirmed in pot experiments in 1986. Capsella bursa-pastoris L. has not been listed up to now among species in which such a resistance was found.

  19. [Polymorphisms of TLR7 rs3853839 and rs179010 are associated with susceptibility to and severity of hand, foot and mouth disease caused by enterovirus 71 in male children].

    Science.gov (United States)

    Li, Yaping; Zhai, Song; Li, Mei; Wang, Yuan; Lu, Tong; Deng, Huiling; Zhang, Xin; Dang, Shuangsuo

    2017-07-01

    Objective To investigate whether the polymorphisms of TLR7/MyD88 signaling pathway is associated with the susceptibility to and severity of hand, foot and mouth disease (HFMD) caused by enterovirus 71 (EV71) in children. Methods We collected 180 EV71 HFMD cases and 201 healthy controls from both the Second Affiliated Hospital of Xi'an Jiaotong University and Xi'an Children's Hospital. The genotypes including rs3853839, rs179010 of TLR7, and rs7744 of MyD88 were detected in the 381 samples by SNPscan kit. Results The susceptibility risk (OR=2.343, 95%CI:1.516-3.621) and severity risk (OR=1.939, 95%CI: 1.064-3.521) of TLR7 rs3853839 allele C significantly increased in the male children with EV71 HFMD. Also, the susceptibility risk (OR=1.701, 95%CI: 1.142-2.535) and severity risk (OR=1.852, 95%CI: 1.038-3.305) of TLR7 rs179010 allele T significantly increased in the male children with EV71 HFMD. But there was no significant difference in the distribution of TLR7 rs179010 and rs3853839 genes between female children with EV71 HFMD and female controls. There was no correlation between the genetic polymorphisms of MyD88 rs7744 and the susceptibility to and severity of EV71 HFMD in the children. Conclusion Polymorphisms of TLR7 rs3853839 and rs179010 are correlated to the susceptibility to and severity of EV71 HFMD in male children.

  20. Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease

    Directory of Open Access Journals (Sweden)

    Muneer G. Hasham

    2017-03-01

    Full Text Available Systemic autoimmune diseases such as systemic lupus erythematosus (SLE and rheumatoid arthritis (RA show significant heart involvement and cardiovascular morbidity, which can be due to systemically increased levels of inflammation or direct autoreactivity targeting cardiac tissue. Despite high clinical relevance, cardiac damage secondary to systemic autoimmunity lacks inducible rodent models. Here, we characterise immune-mediated cardiac tissue damage in a new model of SLE induced by topical application of the Toll-like receptor 7/8 (TLR7/8 agonist Resiquimod. We observe a cardiac phenotype reminiscent of autoimmune-mediated dilated cardiomyopathy, and identify auto-antibodies as major contributors to cardiac tissue damage. Resiquimod-induced heart disease is a highly relevant mouse model for mechanistic and therapeutic studies aiming to protect the heart during autoimmunity.

  1. Delivery of TLR7 agonist to monocytes and dendritic cells by DCIR targeted liposomes induces robust production of anti-cancer cytokines

    DEFF Research Database (Denmark)

    Klauber, Thomas Christopher Bogh; Laursen, Janne Marie; Zucker, Daniel

    2017-01-01

    Tumor immune escape is today recognized as an important cancer hallmark and is therefore a major focus area in cancer therapy. Monocytes and dendritic cells (DCs), which are central to creating a robust anti-tumor immune response and establishing an anti-tumorigenic microenvironment, are directly...... targeted by the tumor escape mechanisms to develop immunosuppressive phenotypes. Providing activated monocytes and DCs to the tumor tissue is therefore an attractive way to break the tumor-derived immune suppression and reinstate cancer immune surveillance. To activate monocytes and DCs with high...... as their immune activating potential in blood-derived monocytes, myeloid DCs (mDCs), and plasmacytoid DCs (pDCs). Monocytes and mDCs were targeted with high specificity over lymphocytes, and exhibited potent TLR7-specific secretion of the anti-cancer cytokines IL-12p70, IFN-α 2a, and IFN-γ. This delivery system...

  2. Innate immune receptors in human airway smooth muscle cells: activation by TLR1/2, TLR3, TLR4, TLR7 and NOD1 agonists.

    Directory of Open Access Journals (Sweden)

    Anne Månsson Kvarnhammar

    Full Text Available BACKGROUND: Pattern-recognition receptors (PRRs, including Toll-like receptors (TLRs, NOD-like receptors (NLRs and RIG-I-like receptors (RLRs, recognize microbial components and trigger a host defense response. Respiratory tract infections are common causes of asthma exacerbations, suggesting a role for PRRs in this process. The present study aimed to examine the expression and function of PRRs on human airway smooth muscle cells (HASMCs. METHODS: Expression of TLR, NLR and RLR mRNA and proteins was determined using real-time RT-PCR, flow cytometry and immunocytochemistry. The functional responses to ligand stimulation were investigated in terms of cytokine and chemokine release, cell surface marker expression, proliferation and proteins regulating the contractile state. RESULTS: HASMCs expressed functional TLR2, TLR3, TLR4, TLR7 and NOD1. Stimulation with the corresponding agonists Pam3CSK4, poly(I:C, LPS, R-837 and iE-DAP, respectively, induced IL-6, IL-8 and GM-CSF release and up-regulation of ICAM-1 and HLA-DR, while poly(I:C also affected the release of eotaxin and RANTES. The proliferative response was slightly increased by LPS. Stimulation, most prominently with poly(I:C, down-regulated myosin light chain kinase and cysteinyl leukotriene 1 receptor expression and up-regulated β2-adrenoceptor expression. No effects were seen for agonist to TLR2/6, TLR5, TLR8, TLR9, NOD2 or RIG-I/MDA-5. CONCLUSION: Activation of TLR2, TLR3, TLR4, TLR7 and NOD1 favors a synthetic phenotype, characterized by an increased ability to release inflammatory mediators, acquire immunomodulatory properties by recruiting and interacting with other cells, and reduce the contractile state. The PRRs might therefore be of therapeutic use in the management of asthma and infection-induced disease exacerbations.

  3. Efficiency of Bursa Malaysia : analyzing Islamic indices and their counterparties

    OpenAIRE

    Kabbani, Abdul Latif

    2016-01-01

    Although Islamic capital markets are considered an emerging market, the improvement is significantly high which requires permanent study. In this empirical study, we go through the Malaysian index using the daily data of the FTSE Bursa Malaysia composite index (FBMKLCI) and two Shariah indices FTSE Bursa Malaysia (EMAS Shariah and HIJRA Shariah). First we analyse the efficient market hypothesis in the weak form using variance ratio and unit root test. Our results show that both markets (Shari...

  4. A tryptophan-rich motif in the human parainfluenza virus type 2 V protein is critical for the blockade of toll-like receptor 7 (TLR7)- and TLR9-dependent signaling.

    Science.gov (United States)

    Kitagawa, Yoshinori; Yamaguchi, Mayu; Zhou, Min; Komatsu, Takayuki; Nishio, Machiko; Sugiyama, Tsuyoshi; Takeuchi, Kenji; Itoh, Masae; Gotoh, Bin

    2011-05-01

    Plasmacytoid dendritic cells (pDCs) do not produce alpha interferon (IFN-α) unless viruses cause a systemic infection or overcome the first-line defense provided by conventional DCs and macrophages. We show here that even paramyxoviruses, whose infections are restricted to the respiratory tract, have a V protein able to prevent Toll-like receptor 7 (TLR7)- and TLR9-dependent IFN-α induction specific to pDCs. Mutational analysis of human parainfluenza virus type 2 demonstrates that the second Trp residue of the Trp-rich motif (Trp-X(3)-Trp-X(9)-Trp) in the C-terminal domain unique to V, a determinant for IRF7 binding, is critical for the blockade of TLR7/9-dependent signaling.

  5. TLR4 and TLR7/8 Adjuvant Combinations Generate Different Vaccine Antigen-Specific Immune Outcomes in Minipigs when Administered via the ID or IN Routes.

    Directory of Open Access Journals (Sweden)

    Paul F McKay

    Full Text Available The induction of high levels of systemic and mucosal humoral immunity is a key goal for many prophylactic vaccines. However, adjuvant strategies developed in mice have often performed poorly in the clinic. Due to their closer similarity to humans, minipigs may provide a more accurate picture of adjuvant performance. Based on their complementary signalling pathways, we assessed humoral immune responses to model antigens after co-administration with the toll-like receptor 4 (TLR4 stimulator glucopyranosyl lipid adjuvant (GLA-AF or the TLR7/8 agonist resiquimod (R848 (alone and in combination via the intradermal (ID, intranasal (IN or combined routes in the Gottingen minipig animal model. Surprisingly, we discovered that while GLA-AF additively enhanced the adjuvant effect of R848 when injected ID, it abrogated the adjuvant activity of R848 after IN inoculation. We then performed a route comparison study using a CN54 gp140 HIV Envelope model antigen adjuvanted with R848 + GLA-AF (ID or R848 alone (IN. Animals receiving priming inoculations via one route were then boosted by the alternate route. Although differences were observed in the priming phase (IN or ID, responses converged upon boosting by the alternative route with no observable impact resultant from the order of administration (ID/IN vs IN/ID. Specific IgG responses were measured at a distal mucosal site (vaginal, although there was no evidence of mucosal linkage as these closely reflected serum antibody levels. These data indicate that the complex in vivo cross-talk between innate pathways are likely tissue specific and cannot be predicted by simple in vitro models.

  6. High-resolution Sonographic Measurements of Lower Extremity Bursae in Chinese Healthy Young Men

    Directory of Open Access Journals (Sweden)

    Yong-Yan Gao

    2016-01-01

    Conclusions: Using HR-US imaging, we were able to analyze lower extremity bursae with high detection rates in healthy young men. The normal ranges of lower extremity bursa dimensions in healthy young men measured by HR-US in this study could be used as reference values for evaluation of bursa abnormalities in the lower extremity.

  7. The Determinants of FTSE4 Good Bursa Malaysia

    Directory of Open Access Journals (Sweden)

    Abu Nor ‘Asyiqin

    2017-01-01

    Full Text Available This study was conducted to identify the factors that influence the companies listed in Bursa Malaysia to be indexed as FTSE4Good Bursa Malaysia (F4GBM. The companies awarded as F4GBM are those with good sustainable practices. This study investigates the potential factors that explain the good sustainable practice (i.e. corporate size, financial performance, industry attachment and sharia-compliant. Analysis reveals that only corporate size which proxy by market capitalization has significant relationship with good sustainable practice.

  8. MR Imaging Features of Obturator Internus Bursa of the Hip

    International Nuclear Information System (INIS)

    Hwang, Ji Young; Lee, Sun Wha; Kim, Jong Oh

    2008-01-01

    The authors report two cases with distension of the obturator internus bursa identified on MR images, and describe the location and characteristic features of obturator internus bursitis; the 'boomerang'-shaped fluid distension between the obturator internus tendon and the posterior grooved surface of the ischium

  9. Determination of native woody landscape plants in Bursa and Uludag

    African Journals Online (AJOL)

    Around Bursa and Uludag is a wide range of native woody plants of which are commonly used for landscape planning. The present study pointed out a total of 72 plant species, consisting of 36 trees, 32 shrubs, 7 treelets and 4 climber groups, around the region which are notified to be suitable for rural and urban planning ...

  10. MR Imaging Features of Obturator Internus Bursa of the Hip

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Ji Young; Lee, Sun Wha; Kim, Jong Oh [School of Medicine, Ewha Womans University, Seoul (Korea, Republic of)

    2008-08-15

    The authors report two cases with distension of the obturator internus bursa identified on MR images, and describe the location and characteristic features of obturator internus bursitis; the 'boomerang'-shaped fluid distension between the obturator internus tendon and the posterior grooved surface of the ischium

  11. A Tryptophan-Rich Motif in the Human Parainfluenza Virus Type 2 V Protein Is Critical for the Blockade of Toll-Like Receptor 7 (TLR7)- and TLR9-Dependent Signaling▿

    OpenAIRE

    Kitagawa, Yoshinori; Yamaguchi, Mayu; Zhou, Min; Komatsu, Takayuki; Nishio, Machiko; Sugiyama, Tsuyoshi; Takeuchi, Kenji; Itoh, Masae; Gotoh, Bin

    2011-01-01

    Plasmacytoid dendritic cells (pDCs) do not produce alpha interferon (IFN-α) unless viruses cause a systemic infection or overcome the first-line defense provided by conventional DCs and macrophages. We show here that even paramyxoviruses, whose infections are restricted to the respiratory tract, have a V protein able to prevent Toll-like receptor 7 (TLR7)- and TLR9-dependent IFN-α induction specific to pDCs. Mutational analysis of human parainfluenza virus type 2 demonstrates that the second ...

  12. Multiresolution analysis of Bursa Malaysia KLCI time series

    Science.gov (United States)

    Ismail, Mohd Tahir; Dghais, Amel Abdoullah Ahmed

    2017-05-01

    In general, a time series is simply a sequence of numbers collected at regular intervals over a period. Financial time series data processing is concerned with the theory and practice of processing asset price over time, such as currency, commodity data, and stock market data. The primary aim of this study is to understand the fundamental characteristics of selected financial time series by using the time as well as the frequency domain analysis. After that prediction can be executed for the desired system for in sample forecasting. In this study, multiresolution analysis which the assist of discrete wavelet transforms (DWT) and maximal overlap discrete wavelet transform (MODWT) will be used to pinpoint special characteristics of Bursa Malaysia KLCI (Kuala Lumpur Composite Index) daily closing prices and return values. In addition, further case study discussions include the modeling of Bursa Malaysia KLCI using linear ARIMA with wavelets to address how multiresolution approach improves fitting and forecasting results.

  13. Bursae and abscess cavities communicating with the hip: diagnosis using arthrography and CT

    International Nuclear Information System (INIS)

    Steinbach, L.S.; Schneider, R.; Goldman, A.B.; Kazam, E.; Ranawat, C.S.; Ghelman, B.

    1985-01-01

    Bursae or abscess cavities communicating with the hip joint were demonstrated by hip arthrography or by computed tomography (CT) in 40 cases. The bursae or abscess cavities were associated with underlying abnormalities in the hip, including painful hip prostheses, infection, and inflammatory or degenerative arthritis. Symptoms may be produced directly as a result of infection or indirectly as a result of inflammation or pressure on adjacent structures. Hip arthrography can confirm a diagnosis of bursae and abscess cavities communicating with the hip joint in patients with hip pain or soft-tissue masses around the groin. Differentiation of enlarged bursae from other abnormalities is important to avoid unnecessary or incorrect surgery

  14. A radiographic study of the distal interphalangeal joint and navicular bursa of the horse

    International Nuclear Information System (INIS)

    Gibson, K.T.; McIlwraith, C.W.; Park, R.D.

    1990-01-01

    Radiographic contrast studies were used in 50 forelimbs from 13 live horses and 12 fresh adult cadavers to determine the frequency of communication between the navicular bursa and the distal interphalangeal joint. Injections of contrast medium were made into the dorsal aspect of the distal interphalangeal joint of one limb and into the navicular bursa of the other forelimb of each horse. In 25 limbs in which contrast medium was injected into the distal interphalangeal joint, no communication was demonstrated between the joint and the navicular bursa. In 20 of the 25 limbs in which injection was made into the navicular bursa, no communication between joint and bursa was seen. In five horses, contrast medium was visible in both the distal interphalangeal joint and the navicular bursa. However, in four of five horses the communication was clearly iatrogenic. In both limbs of one horse, contrast medium was seen to enter the digital flexor tendon sheath after injection into the navicular bursa.There is probably no naturally occurring communication between the navicular bursa and distal interphalangeal joint in the horse

  15. Cost of Capital and Bursa Malaysia Listed Company

    OpenAIRE

    Lim, Ru Po

    2005-01-01

    This study estimates the cost of capital of 226 securities listed in the Bursa Malaysia. The study's sample covers the period from January 1992 to August 2005. The cost of capital using Ordinary Least Squares Regression is first obtained. Next, the cost of capital using the 3 techniques which are the Scholes-Williams, the Dimson and Fowler-Rorke beta estimators for correction for nonsynchronous bias due to thin trading is applied. This study differs from the previous studies as this extends b...

  16. Effect of gamma rays on the larvae of Rhipicephalus bursa

    International Nuclear Information System (INIS)

    Gecheva, G.

    1979-01-01

    Rhipicephalus bursa larvae were exposed to a single acute gamma-irradiation from cobalt 60 source in doses from 0.5 to 40 kiloroentgen (kr). Doses higher than 20 kr rilled the larvae, lower than 10 kr produced disturbances in tick development, dependent on radiation; larvae irradiated with 2 to 3 kr started sucking blood as larvae ordinarily do, but could not undergo metamorphosis; larvae irradiated with lower doses (0.5 and 1 kr) had a prolonged metamorphosis, the onset of oviposition was delayed and the percentage of hatched second generation larvae was reduced. (A.B.)

  17. Intermetatarsal bursa primary synovial chondromatosis. Case report and review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Trevino, Manuel; Laks, Shaked; Sundarakumar, Dinesh K.; Smith, Crysela M. [Texas Tech Univ. Health Science Center, El Paso, TX (United States). Dept. of Radiology; Kafchinski, Lisa [Texas Tech Univ. Health Science Center, El Paso, TX (United States). Dept. of Orthopedic Surgery and Rehabilitation

    2017-12-15

    Primary synovial chondromatosis is a benign neoplastic process, occurring mostly in large joints, more rarely in tendon sheaths, and extremely uncommonly in bursae. We describe a patient with primary synovial chondromatosis arising in the fourth intermetatarsal bursa. Knowledge of the bursal anatomy of the forefoot, and of characteristic imaging findings and the pathogenesis of synovial chondromatosis, is essential in including this uncommon entity in the differential when occurring in unusual locations. (orig.)

  18. Considering the Effect of Hydro Alcoholic Extract of Capsella Bursa Pastoris on Menorrhagia

    Directory of Open Access Journals (Sweden)

    Mahdis Naafe

    2016-04-01

    Full Text Available Abstract Background: Heavy menstrual bleeding has a negative impact on quality of life. In this study, the effect of hydroalcoholic extract of capsella bursa pastoris on menorrhagia is evaluated. Materials and Methods: This clinical trial was carried out on 90 women with complaint of heavy menstrual bleeding. Samples, after a control cycle of primary bleeding, were randomly divided to capsella bursa pastoris and control groups. Both groups were subjected to mefenamic acid treatment with 500 mg every 8 hours, from the first day to the end of bleeding, up to seven days, for two consecutive cycles. In capsella bursa pastoris group, in addition to mefenamic acid, capsella bursa pastoris capsule 500 mg every12 hours, from the first day to the end of bleeding, up to seven days, was prescribed. In control group, instead of capsella bursa pastoris capsules,it,s placebo was prescribed with the same order. Data were checked and compared before and after treatment using SPSS software. Results: The average amount of bleeding reduced in capsella bursa pastoris group from 135.27 in control cycle to 69.13 in third cycle and in control group reduced from 133.91 to 75.44 in third cycle(p<0.001. The average duration of bleeding was reduced in capsella bursa pastoris group from 7.38 in control cycle to 5.40 in third cycle and in control group was reduced from 6.91 to 5.31 in third cycle(p<0.001. Conclusion: It seems that the extract of capsella bursa pastoris can be effective in reducing the amount and duration of bleeding in women of reproductive age with heavy menstrual bleeding.

  19. Bacterial colonization of the ovarian bursa in dogs with clinically suspected pyometra and in controls.

    Science.gov (United States)

    Rubio, Alejandro; Boyen, Filip; Tas, Olaf; Kitshoff, Adriaan; Polis, Ingeborgh; Van Goethem, Bart; de Rooster, Hilde

    2014-10-15

    Septic peritonitis occurs relatively commonly in dogs. Secondary septic peritonitis is usually associated with perforation of intestines or infected viscera, such as the uterus in pyometra cases. The aim of this study was to evaluate the bacterial flora in the ovarian bursae of intact bitches as a potential source of contamination. One hundred forty dogs, clinically suspected of pyometra, were prospectively enrolled. The control group consisted of 26 dogs that underwent elective ovariohysterectomies and 18 dogs with mammary gland tumors that were neutered at the time of mastectomy. Bacteriology samples were taken aseptically at the time of surgery from the bursae and the uterus in all dogs. Twenty-two dogs that were clinically suspected of pyometra had sterile uterine content ("mucometra" cases); the remaining 118 had positive uterine cultures ("pyometra" cases) and septic peritoneal fluid was present in 10% of these cases. Of the 118 pyometra cases, 9 had unilateral and 15 had bilateral bacterial colonization of their ovarian bursae. However, the bacteria from the ovarian bursa were similar to those recovered from the uterine pus in only half of the cases. Furthermore, positive bursae were also seen in one mucometra dog (unilateral) and in four control dogs (two unilateral and two bilateral). The data illustrate that the canine ovarian bursa can harbor bacteria. The biological importance of these isolations remains unclear. Copyright © 2014 Elsevier Inc. All rights reserved.

  20. Potential of bursa-immigrated hematopoietic precursor cells to differentiate to functional B and T cells

    International Nuclear Information System (INIS)

    Weber, W.T.; Alexander, J.E.

    1978-01-01

    The potential of hematopoietic precursor cells, recently immigrated into the 13- and 14-day-old embryonic bursa, to migrate to the thymus and to differentiate to functional T cells was investigated. Chromosomally marked cell populations obtained from 13- and 14-day-old embryonic bursas were transferred i.v. to 780 R γ-irradiated chick embryos of equivalent age. When appropriate chimeras were examined at 4 to 12 weeks after cell transfer, donor cells were found to proliferate primarily in the bursa. Significant donor cell influx into the thymus was not detected. In correlation with these findings, Con A- and PHA-responsive T cells in thymus and spleen cell cultures of recipients remained of host origin whereas the number of anti-CIg responsive B cells of donor type increased gradually in the spleens of recipients. An initial lag period preceded the accumulation of functional donor B cells in the spleens of recipients, despite the predominant presence of dividing donor cells in the bursa. This suggests that the transferred bursal cell population required substantially longer to mature and emigrate from the bursa as functional B cells than the host cell population remaining in the irradiated bursas at time of cell transfer. The failure to detect significant influx of donor cells into the thymus and their failure to differentiate to functional T cells suggest that the recently bursa-immigrated hematopoietic stem cells of 13- and 14-day-old embryos may not be pluripotential cells, but rather cells already committed to the B cell line of differentiation

  1. Metabolic Syndrome among Women: A Study from Bursa Turkey

    Directory of Open Access Journals (Sweden)

    Hasan Orhan

    2011-08-01

    Full Text Available AIM: Obesity is one of the risk factors of metabolic syndrome (MetS and its prevalence is rapidly increasing in Turkey. The purpose of this study was to assess the prevalence of MetS and obesity among women aged 20 years and older. METHOD: This is a cross- sectional study, undergone in a primary health care setting in Bursa /Turkey in the year 2008. A total of 807 women were included in the study. Body weight, height, waist circumference, blood pressure, total and HDL cholesterol, fasting plasma glucose and triglyceride levels were measured. Metabolic Syndrome definition was made according to the International Diabetes Federation (IDF criteria. RESULTS: The mean age was 42.713.2 years, 96.4% were married, 50.7% had education of less than 8 years, 93.7% were housewives and 85.3% had a monthly family income of $650 or less. The prevalence of MetS and abdominal obesity were 17.5 % and 87.7% respectively. Those with diabetes mellitus and elevated plasma lipids had increased risk of developing MetS 11.3 and 4.5 times more than those without these situations respectively. The risk of MetS increases with age and increasing BMI. CONCLUSION: Obesity is an alarming risk factor for the development of MetS in our study group. [TAF Prev Med Bull 2011; 10(4.000: 421-432

  2. Chemical composition and biological screening of Capsella bursa-pastoris

    Directory of Open Access Journals (Sweden)

    Clara Grosso

    2011-06-01

    Full Text Available Capsella bursa-pastoris (L. Medik. (Brassicaceae is a wild herb with high nutritional value that can be eaten raw or cooked. A metabolomic study was performed with different extracts of its aerial parts that were tested concerning their antiradical, acetylcholinesterase inhibitory and antibacterial activities. Phenolic compounds were identified and quantified by HPLC-DAD, organic acids and amino acids were determined by HPLC-UV, while free fatty acids and sterols were analysed by GC-ITMS. The vegetal material was rich in kaempferol-3-O-rutinoside (mean value 2247.09 mg/kg of dry plant, quinic acid (95628.00 mg/kg of dry plant, arginine (mean value of 1.18 mg/kg of dry plant, palmitic acid (284.48 mg/kg and β-sitosterol (28%. The extracts presented a concentration-dependent antiradical activity (against DPPH•, O2•- and LOO•, being most effective against •NO (EC25 0.20 µg/mL. In addition, the extracts were also acetylcholinesterase inhibitors and antibacterial active, revealing that, besides the plant's good nutritional value, it presents important biological properties as well.

  3. Chemical composition and biological screening of Capsella bursa-pastoris

    Directory of Open Access Journals (Sweden)

    Clara Grosso

    2011-08-01

    Full Text Available Capsella bursa-pastoris (L. Medik. (Brassicaceae is a wild herb with high nutritional value that can be eaten raw or cooked. A metabolomic study was performed with different extracts of its aerial parts that were tested concerning their antiradical, acetylcholinesterase inhibitory and antibacterial activities. Phenolic compounds were identified and quantified by HPLC-DAD, organic acids and amino acids were determined by HPLC-UV, while free fatty acids and sterols were analysed by GC-ITMS. The vegetal material was rich in kaempferol-3-O-rutinoside (mean value 2247.09 mg/kg of dry plant, quinic acid (95628.00 mg/kg of dry plant, arginine (mean value of 1.18 mg/kg of dry plant, palmitic acid (284.48 mg/kg and β-sitosterol (28%. The extracts presented a concentration-dependent antiradical activity (against DPPH•, O2•- and LOO•, being most effective against •NO (EC25 0.20 µg/mL. In addition, the extracts were also acetylcholinesterase inhibitors and antibacterial active, revealing that, besides the plant's good nutritional value, it presents important biological properties as well.

  4. Radial and ulnar bursae of the wrist: cadaveric investigation of regional anatomy with ultrasonographic-guided tenography and MR imaging

    International Nuclear Information System (INIS)

    Aguiar, R.O.C.; Gasparetto, E.L.; Marchiori, E.; Escuissato, D.L.; Trudell, D.J.; Haghighi, P.; Resnik, D.

    2006-01-01

    To demonstrate the anatomy of the radial and ulnar bursae of the wrist using MR and US images. Ultrasonographic-guided tenography of the tendon sheath of flexor pollicis longus (FPL) and the common tendon sheath of the flexor digitorum of the fifth digit (FD5) of ten cadaveric hands was performed, followed by magnetic resonance imaging and gross anatomic correlation. Patterns of communication were observed between these tendon sheaths and the radial and ulnar bursae of the wrist. The tendon sheath of the FPL communicated with the radial bursa in 100% (10/10) of cases, and the tendon sheath of the FD5 communicated with the ulnar bursa in 80% (8/10). Communication of the radial and ulnar bursae was evident in 100% (10/10), and presented an ''hourglass'' configuration in the longitudinal plane. The ulnar and radial bursae often communicate. The radial bursa communicates with the FPL tendon sheath, and the ulnar bursa may communicate with the FD5 tendon sheath

  5. MR imaging after therapeutic injection of the subacromial bursa

    Energy Technology Data Exchange (ETDEWEB)

    Major, N.M. [Duke University Medical Center, Department of Radiology, Division Musculoskeletal, Durham, NC (United States)

    1999-11-01

    Objective. As a therapeutic injection into the subacromial bursa (SAB) is commonly performed for impingement syndrome, it is important to know whether this fluid can be retained for a period of time and cause confusion with a pathologic collection of fluid. This study identifies and describes the appearance of recent subacromial injection using MR imaging, and the appearance of a potential complication.Design and patients. Fourteen asymptomatic shoulders were studied with MR imaging using fast spin echo T2-weighted imaging (1.5 T) prior to injection with 7 cm{sup 3} of xylocaine. Four shoulders had subacromial fluid and were eliminated from the study. The remaining 10 (9 men, 1 woman; age range 27-36 years, average age 33 years) were then re-imaged immediately, and at 6, 12 and 24 h after the injection or until fluid resolved. Each set of images was reviewed for the presence of fluid in the SAB and for additional abnormalities.Results. Fluid was identified in all subjects in the SAB in the immediate, 6 and 12 h post-injection images. At 24 h, fluid was not identified within the SAB in eight of 10 patients. In one patient fluid resolved in 48 h. The other continued to demonstrate fluid in the SAB and in the joint as well as abnormal signal in the infraspinatus muscle from a presumed myositis. Imaging was performed up to 10 days after the injection in this patient.Conclusions. It is known that fluid identified in the SAB without evidence of a cuff tear may be due to bursitis. However, if MR imaging is performed within 24 h of injection, the presence of the fluid may be iatrogenic. In addition, the history of recent therapeutic injection is very important as complications such as myositis can occur as a result of the injection. Knowledge of injection prior to imaging is vital for accurate interpretation of MR shoulder examinations. (orig.)

  6. Electrical and Electronical Waste Generation in Turkey: Bursa Case Study

    Directory of Open Access Journals (Sweden)

    Güray SALİHOĞLU

    2016-10-01

    Full Text Available Electrical and electronical equipment that gradually take more place in our daily life, spend their service life in short times and become an e-waste problem to be solved.  Because of the hazardous components they contain, e-waste can cause environmental and human health threats if they are not properly managed. If they are managed properly, they can be a valuable raw material source, since they contain valuable metals such as copper, silver, gold, palladium and recyclable components such as plastics and metals. According to a research conducted in 2014, the global e-waste amount accounts to a source worth 52 billion $; however, only 16% of this source has been properly recycled. It is important to know the potential e-waste amount and the behaviors of people in the production of e-waste to realize a proper e-waste management in our country. The amount and property of electrical and electronic equipment and e-waste generation potential per person in Bursa was investigated in this study. A questionnaire was prepared and applied to a group of people including 31 families (100 person. The questions were to investigate the behaviors in the use, replacement, and management of electrical and electronical equipment. The findings showed that usage of lamps (fluorescent and others were higher than the other equipment, and usage of mobile phones were found to be highest in terms of devices. It was also found that when the mobiles become e-waste since the owners do not want to use them, they are not just thrown away and kept at homes instead. E-waste generation potential of a person from the families investigated was estimated to be 8.14 kg/year.

  7. MR imaging after therapeutic injection of the subacromial bursa

    International Nuclear Information System (INIS)

    Major, N.M.

    1999-01-01

    Objective. As a therapeutic injection into the subacromial bursa (SAB) is commonly performed for impingement syndrome, it is important to know whether this fluid can be retained for a period of time and cause confusion with a pathologic collection of fluid. This study identifies and describes the appearance of recent subacromial injection using MR imaging, and the appearance of a potential complication.Design and patients. Fourteen asymptomatic shoulders were studied with MR imaging using fast spin echo T2-weighted imaging (1.5 T) prior to injection with 7 cm 3 of xylocaine. Four shoulders had subacromial fluid and were eliminated from the study. The remaining 10 (9 men, 1 woman; age range 27-36 years, average age 33 years) were then re-imaged immediately, and at 6, 12 and 24 h after the injection or until fluid resolved. Each set of images was reviewed for the presence of fluid in the SAB and for additional abnormalities.Results. Fluid was identified in all subjects in the SAB in the immediate, 6 and 12 h post-injection images. At 24 h, fluid was not identified within the SAB in eight of 10 patients. In one patient fluid resolved in 48 h. The other continued to demonstrate fluid in the SAB and in the joint as well as abnormal signal in the infraspinatus muscle from a presumed myositis. Imaging was performed up to 10 days after the injection in this patient.Conclusions. It is known that fluid identified in the SAB without evidence of a cuff tear may be due to bursitis. However, if MR imaging is performed within 24 h of injection, the presence of the fluid may be iatrogenic. In addition, the history of recent therapeutic injection is very important as complications such as myositis can occur as a result of the injection. Knowledge of injection prior to imaging is vital for accurate interpretation of MR shoulder examinations. (orig.)

  8. Investigating early modern Ottoman consumer culture in the light of Bursa probate inventories.

    Science.gov (United States)

    Karababa, Eminegül

    2012-01-01

    This study investigates the development of early modern Ottoman consumer culture. In particular, the democratization of consumption, which is a significant indicator of the development of western consumer cultures, is examined in relation to Ottoman society. Sixteenth- and seventeenth-century probate inventories of the town of Bursa combined with literary and official sources are used in order to identify democratization of consumption and the macro conditions shaping this development. Findings demonstrate that commercialization, international trade, urbanization which created a fluid social structure, and the ability of the state to negotiate with guilds were possible contextual specificities which encouraged the democratization of consumption in the Bursa context.

  9. Aspectos determinantes en la presentación de la enfermedad infecciosa de la bursa

    OpenAIRE

    Jaimes-Olaya, Javier Andrés; Álvarez Espejo, Diana Claudia; Correa, Jairo Jaime; Vera Alfonso, Víctor Julio

    2009-01-01

    La enfermedad infecciosa de la bursa, o enfermedad de Gumboro, es una patología inmunosupresiva de las aves de gran importancia en la industria avícola, debido a las grandes pérdidas económicas que produce no sólo por su efecto directo, sino por la predisposición a infecciones secundarias y a la interferencia con las vacunas comerciales, disminuyendo la eficacia de éstas. Es producida por el virus de la enfermedad infecciosa de la bursa (IBDV), el cual es un birnavirus de genoma RNA, con alta...

  10. Dynamic enhanced MRI of the subacromial bursa: correlation with arthroscopic and histological findings

    International Nuclear Information System (INIS)

    Matsuzaki, S.; Yoneda, M.; Kobayashi, Y.; Fukushima, S.; Wakitani, S.

    2003-01-01

    Objective: To assess dynamic MRI with Gd-DTPA enhancement for evaluating inflammatory changes in the subacromial bursa. Design and patients: We detected the signal intensity changes in dynamic MRI of the subacromial bursa, and confirmed these macroscopically by arthroscopy and histologically. The signal intensity was measured using built-in software, and the enhancement ratio (E ratio) was calculated from dynamic MR images. In addition, as a parameter of the rate of the increase in the signal intensity from 0 to 80 s, the mean increase per second in the E ratio was obtained as the coefficient of enhancement (CE). The correlation was studied of the E ratio and CE with the arthroscopic findings (redness, villous formation, thickening and adhesion), and of the E ratio and CE with the histological findings (capillary proliferation, papillary hyperplasia, fibrosis and inflammatory cell infiltration) of the subacromial bursa. Of patients with shoulder pain, this study included those with rotator cuff injury; patients with rheumatoid arthritis or pitching shoulder disorders were excluded. There were 27 patients (15 men, 12 women) ranging in age from 25 to 73 years (mean 49.1 years). Dynamic MRI of the shoulder was also performed on the healthy side of 10 patients and in five normal young volunteers. Results and conclusions: Changes in signal intensity on dynamic MRI were measured in the subacromial bursa. The E ratio (80 s) and CE (0-80 s) were significantly correlated with redness and villous formation as arthroscopic findings, positively correlated with capillary proliferation and papillary hyperplasia as histological findings (p < 0.05), and negatively correlated with fibrosis as a histological finding (p < 0.05) in the subacromial bursa. The patterns of dynamic curves were well correlated with the bursoscopic and histological findings of the synovium of the subacromial bursa. Dynamic MRI appears to correlate with inflammatory activity of synovium of the subacromial

  11. [Treatment of traumatic lesions of the bursa olecrani and chronic bursitis olecrani].

    Science.gov (United States)

    Saul, D; Dresing, K

    2017-06-01

    Complete olecranon bursectomy with debridement, protection of veins and nerves. Risk-adapted antibiotic therapy and early functional aftercare. Acute, traumatic laceration of the bursa olecrani, chronic therapy-resistant bursitis olecrani. For traumatic bursa injuries: general contraindications for anesthesia and surgery; chronic bursitis: initially not closable skin defect (plastic surgery required), hemodynamically instable patient (e.g. systemic inflammatory response syndrome [SIRS] or sepsis), pre-existing skin infection. Local anesthesia beyond the lesion, careful debridement, identification and removal of the entire bursa, excision of contaminated skin, lavage, drain insertion (Redon, Easy-flow, Penrose). Wound closure, elastic bandage, and splint. Elastic bandage for 2 days, followed by drain removal. Wound assessment, early functional aftercare without splint, antibiotic therapy in septic bursitis for 2 weeks, PRICE scheme. Removal of stitches after 10-12 days. Over 5 years, 138 cases of traumatic bursa lesion or chronic bursitis olecrani were treated in our clinic, 82 patients underwent surgery. Ten patients were treated with vacuum-assisted closure therapy and consecutive wound healing; fistulae occurred in two patients and in another two dehiscence developed. All of the defects could be closed without flaps.

  12. Retrocalcaneal bursitis but not Achilles tendinopathy is characterized by increased pressure in the retrocalcaneal bursa.

    Science.gov (United States)

    Lohrer, Heinz; Nauck, Tanja

    2014-03-01

    We questioned whether different forms of Achilles tendon overuse injuries can be differentiated by retrocalcaneal bursa pressure measurement. Retrocalcaneal bursa pressure was determined by using invasive pressure measurement in patients suffering from retrocalcaneal bursitis (n=13) or Achilles tendinopathy (n=15), respectively. Standardized measurements were taken with the subject lying prone. Initially, the foot and ankle was in a spontaneous, unsupported position. Then passive dorsiflexion was induced by an increasing pressure which was applied in five defined steps against the plantar forefoot. Mean pressures found in unloaded position were 30.5 (SD 28.9) mmHg in retrocalcaneal bursitis and -9.9 (SD 17.2) mmHg in Achilles tendinopathy (pbursitis and 32.5 (SD 48.9) mmHg for Achilles tendinopathy (p=0,051). Higher retrocalcaneal bursa pressure values were found in patients suffering from chronic retrocalcaneal bursitis. This result supports the hypothesis that retrocalcaneal bursa hypertension leads to an impingement lesion of the corresponding anterior Achilles tendon. Copyright © 2013 Elsevier Ltd. All rights reserved.

  13. Apoptosis in the chicken bursa of fabricius induced by X-irradiation.

    Science.gov (United States)

    Arai, S; Kowada, T; Takehana, K; Miyoshi, K; Nakanishi, Y H; Hayashi, M

    1996-10-01

    Immature B lymphocytes in the chicken bursa of Fabricius have previously been reported to undergo apoptosis by low doses of ionizing radiation. In the present study, newly hatched chickens were subjected to whole-body X-irradiation, and the bursa of Fabricius was examined at various postirradiation times by light and electron microscopy to obtain information on the change of ultrastructure of irradiated bursal cells as well as on the time course and dose-response for the induction of apoptosis. Histological examination by light microscopy showed that pyknotic cells started to increase in the bursa within a few hours after irradiation and the frequency of occurrence reached a maximum at 6 hr. An evident increase of the pyknotic cells in number was observed at a dose of as little as 1 Gy, and the frequency increased with increases in the dose, reaching over 90% at 15 Gy. Electron microscopy of the irradiated bursa revealed typical apoptotic morphology such as chromatin condensation, nuclear fragmentation, formation of apoptotic bodies and phagocytosis of pyknotic cells. Induction of apoptosis was also confirmed by the appearance of a typical DNA ladder pattern on agarose gel. Thus, the present results demonstrate that the chicken bursal cells are hypersensitive to X-irradiation with regard to induction of apoptosis, and that the apoptotic bursal cells exhibit most of the ultrastructural features known to be typical of apoptosis.

  14. Genomic signature of successful colonization of Eurasia by the allopolyploid shepherd's purse (Capsella bursa-pastoris).

    Science.gov (United States)

    Cornille, A; Salcedo, A; Kryvokhyzha, D; Glémin, S; Holm, K; Wright, S I; Lascoux, M

    2016-01-01

    Polyploidization is a dominant feature of flowering plant evolution. However, detailed genomic analyses of the interpopulation diversification of polyploids following genome duplication are still in their infancy, mainly because of methodological limits, both in terms of sequencing and computational analyses. The shepherd's purse (Capsella bursa-pastoris) is one of the most common weed species in the world. It is highly self-fertilizing, and recent genomic data indicate that it is an allopolyploid, resulting from hybridization between the ancestors of the diploid species Capsella grandiflora and Capsella orientalis. Here, we investigated the genomic diversity of C. bursa-pastoris, its population structure and demographic history, following allopolyploidization in Eurasia. To that end, we genotyped 261 C. bursa-pastoris accessions spread across Europe, the Middle East and Asia, using genotyping-by-sequencing, leading to a total of 4274 SNPs after quality control. Bayesian clustering analyses revealed three distinct genetic clusters in Eurasia: one cluster grouping samples from Western Europe and Southeastern Siberia, the second one centred on Eastern Asia and the third one in the Middle East. Approximate Bayesian computation (ABC) supported the hypothesis that C. bursa-pastoris underwent a typical colonization history involving low gene flow among colonizing populations, likely starting from the Middle East towards Europe and followed by successive human-mediated expansions into Eastern Asia. Altogether, these findings bring new insights into the recent multistage colonization history of the allotetraploid C. bursa-pastoris and highlight ABC and genotyping-by-sequencing data as promising but still challenging tools to infer demographic histories of selfing allopolyploids. © 2015 John Wiley & Sons Ltd.

  15. Effects of Shepherd’s Purse (Capsella bursa pastoris (L. Medic. on the Chemical Composition of Lucerne (Medicago sativa L.

    Directory of Open Access Journals (Sweden)

    Tsvetanka Dimitrova

    2008-01-01

    Full Text Available A study was conducted in a pure stand of lucerne (variety Viktoria under natural weed infestation with shepherd’s purse (Capsella bursa pastoris (L. Medic. on a slightly leached chernozem soil under nonirrigated conditions in the experimental field of the Institute ofForage Crops – Pleven during the 2006-2007 period. The effect of shepherd’s purse Capsella bursa pastoris (L. Medic. on the chemical composition of lucerne Medicago sativa (L. was analyzed.Statistically significant (P<0.05 functional relations were found between the chemical characteristics and percentage of Capsella bursa pastoris (L. Medic. participation in the lucerne sward, and forage quality. These relations indicated a multiple practical relevance and a necessity to control Capsella bursa pastoris (L. Medic. in lucerne stands in order to decrease weed density and improve forage quality.

  16. Stability of Durum Wheat Genotypes in Some Agronomic Traits Under Bursa Ecological Conditions

    Directory of Open Access Journals (Sweden)

    Esra Aydoğan Çiftçi

    2017-11-01

    Full Text Available In the study it is aimed to determine the stabilities of some agronomic traits of 10 different durum wheats over the years in conditions of Bursa. Research was carried out in randomized complete block design with three replications between the years of 2008-2013. Averages of genotypes of agronomic characteristics, Eberhart and Russell’s regression coefficient and deviation from regression, Francis and Kannenberg’s coefficient of variation and environmental variance used as stability parameters. When the results of the study evaluated at the stability analysis, Amb × Çak-30 lines were determined to be stable in most of the agronomic traits. As for grain yield, which is of great importance for the producer, breeding lines of Amb × Çak -26 and Amb × Çak-30 were determined in good harmony at Bursa under different climatic conditions over five years.

  17. ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI UNDERPRICING SAHAM PADA PENAWARAN SAHAM PERDANA DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Reza Widhar Pahlevi

    2016-01-01

    Full Text Available Penelitian empiris ini dimaksudkan untuk mengetahui pengaruh Reputasi Underwriter, Reputasi Auditor, Persentase Saham yang ditawarkan ke Publik, Financial Leverage, Profitabilitas (ROA, Profitabilitas (NPM, Current Ratio, Ukuran Perusahaan, Umur Perusahaan, dan Jenis Industri terhadap Underpricing saham pada penawaran saham perdana di Bursa Efek Indonesia tahun 2000-2012. Berdasarkan hasil analisis data, pengujian secara parsial menunjukkan variabelvariabel Reputasi Underwriter, Reputasi Auditor, Persentase Saham yang ditawarkan ke Publik, dan Jenis Industri tidak mempunyai pengaruh yang signifikan terhadap Underpricing, Variabel Financial Leverage berpengaruh positif dan signifikan terhadap Underpricing. Sedangkan Variabel Profitabilitas (ROA, Profitabilitas (NPM, Current Ratio, Ukuran Perusahaan, dan Umur Perusahaan berpengaruh negatif dan signifikan terhadap Underpricing saham pada penawaran saham perdana di Bursa Efek Indonesia.Kata kunci : Initial Public Offering, Initial Return dan Underpricing

  18. Vitamin E as a radioprotector of bursa of Fabricius in chicks

    International Nuclear Information System (INIS)

    Malhotra, N.; Rana, K.; Malhotra, R.K.

    1993-01-01

    Radioprotective influence of vitamin E has been studied on the bursa of Fabricius 1 and 7 day old white leghorn chicks exposed to 2.25 Gy whole body γ-radiations. The study has revealed that the loss of lymphocytic population in the bursal follicles due to irradiation was very small in vitamin E treated animals compared to the untreated irradiated chicks. Also, the rate of reparation and lymphocytic repopulation was enhanced with vitamin E administration. (author). 8 refs., 8 figs

  19. What Managers Really Do? An Emprical Study about Managers’ Roles in Bursa

    Directory of Open Access Journals (Sweden)

    Nilüfer Rüzgar

    2013-12-01

    Full Text Available lthough many studies focus on roles and profiles of the managers in the literature, the roles and the profiles of the managers in Turkish business system has been remained unexplored. This study aims to reveal roles of managers from Bursa based on Mintzberg’s managerial roles categories: interpersonal, informational and decisional roles. According to the findings that managers prominently play interpersonal (leader and informational (monitor roles.

  20. An Analysis of Capital Control and Long Memory Effects in Bursa Malaysia Stock Exchange

    OpenAIRE

    Feng, Weishan

    2006-01-01

    On 1 September 1998, the Malaysian government imposed capital control to recover its economy from Asian financial crisis. This study examined the effect of capital control on Bursa Malaysia Main Board indices. It found the indices reacted quickly to reflect the effect of capital control announcement. The ARFIMA (p, d, q) model then was employed to examine the long memory effects in all indices during five different periods. It is found that long memory existed in Consumer Products Index, and ...

  1. A Power Case Study for Monocrystalline and Polycrystalline Solar Panels in Bursa City, Turkey

    OpenAIRE

    Taşçıoğlu, Ayşegül; Taşkın, Onur; Vardar, Ali

    2016-01-01

    It was intended to reveal the time dependent power generation under different loads for two different solar panels under the conditions of Bursa province in between August 19 and 25, 2014. The testing sets include solar panels, inverter, multimeter, accumulator, regulator, pyranometer, pyrheliometer, temperature sensor, and datalogger. The efficiency of monocrystalline and polycrystalline solar panels was calculated depending on the climatic data’s measurements. As the result of the study, th...

  2. Identification and characterization of a novel adenovirus in the cloacal bursa of gulls

    International Nuclear Information System (INIS)

    Bodewes, R.; Bildt, M.W.G. van de; Schapendonk, C.M.E.; Leeuwen, M. van; Boheemen, S. van; Jong, A.A.W. de; Osterhaus, A.D.M.E.; Smits, S.L.; Kuiken, T.

    2013-01-01

    Several viruses of the family of Adenoviridae are associated with disease in birds. Here we report the detection of a novel adenovirus in the cloacal bursa of herring gulls (Larus argentatus) and lesser black-backed gulls (Larus fuscus) that were found dead in the Netherlands in 2001. Histopathological analysis of the cloacal bursa revealed cytomegaly and karyomegaly with basophilic intranuclear inclusions typical for adenovirus infection. The presence of an adenovirus was confirmed by electron microscopy. By random PCR in combination with deep sequencing, sequences were detected that had the best hit with known adenoviruses. Phylogenetic analysis of complete coding sequences of the hexon, penton and polymerase genes indicates that this novel virus, tentatively named Gull adenovirus, belongs to the genus Aviadenovirus. The present study demonstrates that birds of the Laridae family are infected by family-specific adenoviruses that differ from known adenoviruses in other bird species. - Highlights: ► Lesions typical for adenovirus infection detected in cloacal bursa of dead gulls. ► Confirmation of adenovirus infection by electron microscopy and deep sequencing. ► Sequence analysis indicates that it is a novel adenovirus in the genus Aviadenovirus. ► The novel (Gull) adenovirus was detected in multiple organs of two species of gulls

  3. Ultrasound characteristics of gouty tophi in the olecranon bursa and evaluation of their reproducibility

    International Nuclear Information System (INIS)

    Fernandes, Eloy A.; Lopes, Matheus G.; Mitraud, Sônia A.V.; Ferrari, Antonio J.L.; Fernandes, Artur R.C.

    2012-01-01

    Objectives: To describe the ultrasound characteristics of gouty tophi in the olecranon bursa and to evaluate their reproducibility. Methods: A prospective study of the ultrasound features of 35 sites of tophi nodulations in the elbows of 31 men (mean 54.6 years). The findings were evaluated dynamically following pre-established standards. The static images were evaluated by another radiologist and were reviewed by the first examiner. Results: The most frequent characteristics of tophi are: hyperechogenicity (91.7%), poorly defined contours (88.6%), multiple grouped nodules (85.6%) and heterogeneity (68.6%). Intra-observer agreement is almost perfect for echogenicity (K = 1.0), moderate for the involvement of the olecranon bursa (K = 0.47) and fair for other characteristics. Inter-observer agreement is substantial for the echogenicity (K = 0.65), fair for the echotexture (K = 0.27) and the presence of a perilesional hypoechoic halo (K = 0.34) and slight for other characteristics. Conclusions: The most frequent characteristic of tophi is hyperechogenicity. The intra-observer and inter-observer concordance for echogenicity are almost perfect and substantial, respectively. Knowledge of characteristics of the tophi in the elbow and their intra and inter-observer reproducibility may assist in establishing parameters for monitoring treatment and setting up criteria for differential diagnosis of processes involving the olecraneon bursa.

  4. Contra trading in Bursa Malaysia Securities Berhad: a Sharīʿah and legal appraisal

    Directory of Open Access Journals (Sweden)

    Noor Suhaida Kasri

    2017-07-01

    Full Text Available Purpose - The purpose of this paper is to analyze the practice of contra trading in Bursa Malaysia Securities Berhad. Through a critical examination of the practice, it aims to discuss the issues from the angles of Sharīʿah and Malaysian common law. Design/methodology/approach - The paper uses a qualitative research methodology. The information on the practice of contra trading is obtained through the Bursa Malaysia Securities Berhad’s website and literature as well as series of meetings and discussions held with Bursa Malaysia Securities Berhad. In comprehending and dissecting the Sharīʿah and legal issues, classical along with contemporary Sharīʿah literature including local and international Sharīʿah advisory bodies’ resolutions and standards have been referred to. The Sharīʿah analysis of these issues is further supported by reference to the statute and by-laws of Bursa Malaysia Securities Berhad as well as other related legal literature. Findings - This paper finds that contra trading involves a real sale and purchase of shares; the shares are not taken into the possession of the contra trader, neither physically nor constructively; the liability of shares is not transferred to the contra trader; though the practice of profiting in contra trading may contradict the prohibition on profiting without bearing liability, the permissibility of contra trading could still be argued from the contextual approach of public interest (maṣlaḥah and needs (hājah; and contra trading is not gambling. Research limitations/implications - This paper is limited in its analysis to only Sharīʿah and legal perspectives. It does not cover a thorough empirical and quantitative investigation that would measure the extent of the public needs for contra trading and the real benefits that contra trading brings about to the society in the long run. Such studies will further demonstrate whether contra trading deserves a relaxation from the strict Shar

  5. Perspective Research Progress in Cold Responses of Capsella bursa-pastoris

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    Ali Noman

    2017-08-01

    Full Text Available Plants respond to cold stress by modulating biochemical pathways and array of molecular events. Plant morphology is also affected by the onset of cold conditions culminating at repression in growth as well as yield reduction. As a preventive measure, cascades of complex signal transduction pathways are employed that permit plants to endure freezing or chilling periods. The signaling pathways and related events are regulated by the plant hormonal activity. Recent investigations have provided a prospective understanding about plant response to cold stress by means of developmental pathways e.g., moderate growth involved in cold tolerance. Cold acclimation assays and bioinformatics analyses have revealed the role of potential transcription factors and expression of genes like CBF, COR in response to low temperature stress. Capsella bursa-pastoris is a considerable model plant system for evolutionary and developmental studies. On different occasions it has been proved that C. bursa-pastoris is more capable of tolerating cold than A. thaliana. But, the mechanism for enhanced low or freezing temperature tolerance is still not clear and demands intensive research. Additionally, identification and validation of cold responsive genes in this candidate plant species is imperative for plant stress physiology and molecular breeding studies to improve cold tolerance in crops. We have analyzed the role of different genes and hormones in regulating plant cold resistance with special reference to C. bursa-pastoris. Review of collected data displays potential ability of Capsella as model plant for improvement in cold stress regulation. Information is summarized on cold stress signaling by hormonal control which highlights the substantial achievements and designate gaps that still happen in our understanding.

  6. The Effect of Hydroalcoholic Extracts of Capsella Bursa-Pastoris on Heavy Menstrual Bleeding: A Randomized Clinical Trial.

    Science.gov (United States)

    Naafe, Mahdis; Kariman, Nourossadat; Keshavarz, Zohreh; Khademi, Nasim; Mojab, Faraz; Mohammadbeigi, Abolfazl

    2018-03-20

    Heavy menstrual bleeding (HMB) is one of the leading causes of low quality of life and iron deficiency anemia in women. This study aimed to determine the effect of hydroalcoholic extracts of Capsella bursa-pastoris on HMB. This study is a triple-blinded, randomized clinical trial. The study was conducted in gynecology clinics affiliated to Shahid Beheshti University of Medical Sciences, Tehran, Iran. Our patients affected to a complaint of HMB. After obtaining a complete medical history of the women and filling out the demographic forms, the participants were assigned randomly into the experimental (n = 42) and control groups (n = 42). The eligible participants were given a pictorial blood loss assessment chart (PBLAC) to confirm HMB during the menstrual cycle. The experimental group received two capsules of mefenamic acid (500 mg) every 8 h and two Capsella bursa-pastoris capsules every 12 h. The intervention started from the first day of menstruation to the end of this period up to 7 days for two consecutive cycles. In the control group, the patients received mefenamic acid and placebo instead of Capsella bursa-pastoris capsules. The PBLAC score and number of bleeding days, incidence of any possible problems, as well as participant satisfaction were measured. The data were analyzed using t-test, Chi-square, repeated-measures ANOVA, and ANCOVA tests in PASW Statistics ver. 18. After the intervention, there was observed significant decrease in the amount of menstrual bleeding in both groups. However, the mean decrease in the amount of bleeding was significantly more in the Capsella bursa-pastoris group (p < 0/001). Compared with control group, hydroalcoholic extracts of Capsella bursa-pastoris capsule appeared to be effective in reducing menstrual bleeding in this study. Further research regarding the efficacy and safety of Capsella bursa-pastoris is required.

  7. The dynamic relationship between Bursa Malaysia composite index and macroeconomic variables

    Science.gov (United States)

    Ismail, Mohd Tahir; Rose, Farid Zamani Che; Rahman, Rosmanjawati Abd.

    2017-08-01

    This study investigates and analyzes the long run and short run relationships between Bursa Malaysia Composite index (KLCI) and nine macroeconomic variables in a VAR/VECM framework. After regression analysis seven out the nine macroeconomic variables are chosen for further analysis. The use of Johansen-Juselius Cointegration and Vector Error Correction Model (VECM) technique indicate that there are long run relationships between the seven macroeconomic variables and KLCI. Meanwhile, Granger causality test shows that bidirectional relationship between KLCI and oil price. Furthermore, after 12 months the shock on KLCI are explained by innovations of the seven macroeconomic variables. This indicate the close relationship between macroeconomic variables and KLCI.

  8. Fractional Ornstein-Uhlenbeck for index prices of FTSE Bursa Malaysia KLCI

    Science.gov (United States)

    Chen, Kho Chia; Bahar, Arifah; Ting, Chee-Ming

    2014-07-01

    This paper studies the Ornstein-Uhlenbeck model that incorporates long memory stochastic volatility which is known as fractional Ornstein-Uhlenbeck model. The determination of the existence of long range dependence of the index prices of FTSE Bursa Malaysia KLCI is measured by the Hurst exponent. The empirical distribution of unobserved volatility is estimated using the particle filtering method. The performance between fractional Ornstein -Uhlenbeck and standard Ornstein -Uhlenbeck process had been compared. The mean square errors of the fractional Ornstein-Uhlenbeck model indicated that the model describes index prices better than the standard Ornstein-Uhlenbeck process.

  9. Pendapat Auditor atas Laporan Keuangan untuk Perusahaan yang Terdaftar di Bursa Efek Jakarta

    Directory of Open Access Journals (Sweden)

    Antonius Herusetya

    2007-03-01

    Full Text Available Reports are essentials to audit and assurance engagements because they communicate the result of auditor’s findings. The reason for this research is to study what types of the audit report has been issued for listed public companies in Bursa Efek Jakarta (BEJ. Audited reports from 106 sample companies are examined. Our findings reveal that most of the audit opinion among listed companies in Indonesia is unqualifed opinion (51.89%, followed by unqualified opinion with explanatory paragraph (39.79%, qualified opinion (7.55%, and disclaimer opinion (3.77%. Each audit opinion has its own condition that varies among many companies.

  10. Static vs stochastic optimization: A case study of FTSE Bursa Malaysia sectorial indices

    Science.gov (United States)

    Mamat, Nur Jumaadzan Zaleha; Jaaman, Saiful Hafizah; Ahmad, Rokiah@Rozita

    2014-06-01

    Traditional portfolio optimization methods in the likes of Markowitz' mean-variance model and semi-variance model utilize static expected return and volatility risk from historical data to generate an optimal portfolio. The optimal portfolio may not truly be optimal in reality due to the fact that maximum and minimum values from the data may largely influence the expected return and volatility risk values. This paper considers distributions of assets' return and volatility risk to determine a more realistic optimized portfolio. For illustration purposes, the sectorial indices data in FTSE Bursa Malaysia is employed. The results show that stochastic optimization provides more stable information ratio.

  11. Static vs stochastic optimization: A case study of FTSE Bursa Malaysia sectorial indices

    Energy Technology Data Exchange (ETDEWEB)

    Mamat, Nur Jumaadzan Zaleha; Jaaman, Saiful Hafizah; Ahmad, Rokiah Rozita [School of Mathematical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor (Malaysia)

    2014-06-19

    Traditional portfolio optimization methods in the likes of Markowitz' mean-variance model and semi-variance model utilize static expected return and volatility risk from historical data to generate an optimal portfolio. The optimal portfolio may not truly be optimal in reality due to the fact that maximum and minimum values from the data may largely influence the expected return and volatility risk values. This paper considers distributions of assets' return and volatility risk to determine a more realistic optimized portfolio. For illustration purposes, the sectorial indices data in FTSE Bursa Malaysia is employed. The results show that stochastic optimization provides more stable information ratio.

  12. Static vs stochastic optimization: A case study of FTSE Bursa Malaysia sectorial indices

    International Nuclear Information System (INIS)

    Mamat, Nur Jumaadzan Zaleha; Jaaman, Saiful Hafizah; Ahmad, Rokiah Rozita

    2014-01-01

    Traditional portfolio optimization methods in the likes of Markowitz' mean-variance model and semi-variance model utilize static expected return and volatility risk from historical data to generate an optimal portfolio. The optimal portfolio may not truly be optimal in reality due to the fact that maximum and minimum values from the data may largely influence the expected return and volatility risk values. This paper considers distributions of assets' return and volatility risk to determine a more realistic optimized portfolio. For illustration purposes, the sectorial indices data in FTSE Bursa Malaysia is employed. The results show that stochastic optimization provides more stable information ratio

  13. Dermatitis caused by the tropical fowl mite Ornithonyssus bursa (Berlese (Acari: Macronyssidae: a case report in humans

    Directory of Open Access Journals (Sweden)

    Márcia Bohrer Mentz

    2015-12-01

    Full Text Available Abstract: We herein report human dermatitis caused by the tropical fowl mite Ornithonyssus bursa (Berlese. The cases occurred in an apartment in a residential district of Porto Alegre City, State of Rio Grande do Sul, Brazil, where three members of the same family presented with pruritic lesions on the arms and legs. On inspecting the bathroom, several mites measuring approximately 1.0mm in length were observed coming from a nest of Rufous Hornero, Furnarius rufus (Gmelin. This is the first report of O. bursa in the urban area of Porto Alegre City, from a nest of F. rufus that bites humans.

  14. Suspected nitrite poisoning in pigs caused by Capsella bursa-pastoris (L. Medik. ('herderstassie', shepherd's purse : case report

    Directory of Open Access Journals (Sweden)

    W.J. Wiese

    2001-07-01

    Full Text Available Nitrite poisoning in pigs was suspected when 4 of 18 pigs died in a piggery near Ellisras in the Northern Province. The pigs showed typical brownish discolouration of the blood at autopsy. It was established that they ingested vegetable tops and weeds from the adjacent garden as part of their daily ration. Of the available plants, only Capsella bursa-pastoris contained nitrites. The drinking water and some of the other plants tested positive for nitrates but not for nitrites. This is the first report of suspected nitrite poisoning in pigs caused by Capsella bursa-pastoris.

  15. Stochastic differential equation (SDE) model of opening gold share price of bursa saham malaysia

    Science.gov (United States)

    Hussin, F. N.; Rahman, H. A.; Bahar, A.

    2017-09-01

    Black and Scholes option pricing model is one of the most recognized stochastic differential equation model in mathematical finance. Two parameter estimation methods have been utilized for the Geometric Brownian model (GBM); historical and discrete method. The historical method is a statistical method which uses the property of independence and normality logarithmic return, giving out the simplest parameter estimation. Meanwhile, discrete method considers the function of density of transition from the process of diffusion normal log which has been derived from maximum likelihood method. These two methods are used to find the parameter estimates samples of Malaysians Gold Share Price data such as: Financial Times and Stock Exchange (FTSE) Bursa Malaysia Emas, and Financial Times and Stock Exchange (FTSE) Bursa Malaysia Emas Shariah. Modelling of gold share price is essential since fluctuation of gold affects worldwide economy nowadays, including Malaysia. It is found that discrete method gives the best parameter estimates than historical method due to the smallest Root Mean Square Error (RMSE) value.

  16. Spatial Distribution of Polycyclic Aromatic Hydrocarbon (PAH) Concentrations in Soils from Bursa, Turkey.

    Science.gov (United States)

    Karaca, Gizem

    2016-02-01

    The objectives of this study were to identify regional variations in soil polycyclic aromatic hydrocarbon (PAH) contamination in Bursa, Turkey, and to determine the distributions and sources of various PAH species and their possible sources. Surface soil samples were collected from 20 different locations. The PAH concentrations in soil samples were analyzed using gas chromatography-mass spectrometry (GC-MS). The total PAH concentrations (∑12 PAH) varied spatially between 8 and 4970 ng/g dry matter (DM). The highest concentrations were measured in soils taken from traffic+barbecue+ residential areas (4970 ng/g DM) and areas with cement (4382 ng/g DM) and iron-steel (4000 ng/g DM) factories. In addition, the amounts of ∑7 carcinogenic PAH ranged from 1 to 3684 ng/g DM, and between 5 and 74 % of the total PAHs consisted of such compounds. Overall, 4-ring PAH compounds (Fl, Pyr, BaA and Chr) were dominant in the soil samples, with 29-82 % of the ∑12 PAH consisting of 4-ring PAH compounds. The ∑12 BaPeq values ranged from 0.1 to 381.8 ng/g DM. Following an evaluation of the molecular diagnostic ratios, it was concluded that the PAH pollution in Bursa soil was related to pyrolytic sources; however, the impact of petrogenic sources should not be ignored.

  17. Capsella bursa-pastoris (L.) Medic. as a biomonitor of heavy metals

    International Nuclear Information System (INIS)

    Aksoy, A.; Hale, W.H.G.; Dixon, J.M.

    1999-01-01

    Capsella bursa-pastoris (L.) Medic. (shepherd's purse) has been tested as a possible biomonitor of heavy metals in the city of Bradford, UK and compared with Poa annua L. (annual meadow-grass), a species with a similar ecology that had previously been studied for biomonitoring potential. Forty-two sites (urban roadside, urban, urban park, suburban and rural) in and around Bradford were investigated. Concentrations of Pb, Cd, Zn and Cu have been determined in soils and in washed and unwashed plant leaves. Differences between the washed and unwashed samples, reflecting airborne and soil entry routes, respectively, varied according to the metal pollutant. There were significant relationships between the heavy metal concentration in samples of surface soil (depth 0-10 cm) and washed leaves, the concentrations being greater with progressively increased urbanisation of the sites. Capsella bursa-pastoris has been found to be a useful biomonitor of the four heavy metals studied, and it may be a particularly useful species since it could monitor short-term changes in pollution in urban areas. (Copyright (c) 1999 Elsevier Science B.V., Amsterdam. All rights reserved.)

  18. Capsella bursa-pastoris (L.) Medic. as a biomonitor of heavy metals

    Energy Technology Data Exchange (ETDEWEB)

    Aksoy, A. [University of Erciyes, Faculty of Science and Arts, Department of Biology, 38039 Kayseri (Turkey); Hale, W.H.G.; Dixon, J.M. [Department of Environmental Science, University of Bradford, Bradford (United Kingdom)

    1999-02-09

    Capsella bursa-pastoris (L.) Medic. (shepherd's purse) has been tested as a possible biomonitor of heavy metals in the city of Bradford, UK and compared with Poa annua L. (annual meadow-grass), a species with a similar ecology that had previously been studied for biomonitoring potential. Forty-two sites (urban roadside, urban, urban park, suburban and rural) in and around Bradford were investigated. Concentrations of Pb, Cd, Zn and Cu have been determined in soils and in washed and unwashed plant leaves. Differences between the washed and unwashed samples, reflecting airborne and soil entry routes, respectively, varied according to the metal pollutant. There were significant relationships between the heavy metal concentration in samples of surface soil (depth 0-10 cm) and washed leaves, the concentrations being greater with progressively increased urbanisation of the sites. Capsella bursa-pastoris has been found to be a useful biomonitor of the four heavy metals studied, and it may be a particularly useful species since it could monitor short-term changes in pollution in urban areas. (Copyright (c) 1999 Elsevier Science B.V., Amsterdam. All rights reserved.)

  19. A Power Case Study for Monocrystalline and Polycrystalline Solar Panels in Bursa City, Turkey

    Directory of Open Access Journals (Sweden)

    Ayşegül Taşçıoğlu

    2016-01-01

    Full Text Available It was intended to reveal the time dependent power generation under different loads for two different solar panels under the conditions of Bursa province in between August 19 and 25, 2014. The testing sets include solar panels, inverter, multimeter, accumulator, regulator, pyranometer, pyrheliometer, temperature sensor, and datalogger. The efficiency of monocrystalline and polycrystalline solar panels was calculated depending on the climatic data’s measurements. As the result of the study, the average performances of monocrystalline and polycrystalline panels are 42.06 and 39.80 Wh, respectively. It was seen that 87.14 W instantaneous power could be obtained from monocrystalline solar panel and that 80.17 W instantaneous power could be obtained from polycrystalline solar panel under maximum total radiation (1001.13 W/m2. Within this frame, it was determined that monocrystalline solar panel is able to operate more efficiently under the conditions of Bursa compared to polycrystalline solar panel. When the multivariate correlations coefficients were examined statistically, a significant relationship in positive direction was detected between total and direct radiation and ambient temperature on energy generation from monocrystalline and polycrystalline panel.

  20. Pengaruh Growth Opportunity, Liquidity, Profitability, dan Tangibility terhadap Struktur Modal pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia

    OpenAIRE

    Harahap, Artika Hemdi

    2015-01-01

    Rumusan masalah dalam penelitian ini adalah bagaimana pengaruh komponen growth opportunity, liquidity, profitability, dan tangibility terhadap struktur modal pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia (BEI). Tujuan penelitian ini adalah untuk mengetahui dan menganalisis pengaruh komponen growth opportunity, liquidity, profitability, dan tangibility terhadap struktur modal. Hipotesis dalam penelitian ini adalah komponen growth opportunity, liquidity, profitability, d...

  1. Deep and superficial infrapatellar bursae: cadaveric investigation of regional anatomy using magnetic resonance after ultrasound-guided bursography

    Energy Technology Data Exchange (ETDEWEB)

    Viegas, Flavio C.; Trudell, Debbie J.; Haghighi, Parviz; Resnick, Donald [Veterans Affairs Medical Center - San Diego, San Diego, CA (United States); Aguiar, Rodrigo O.C. [Veterans Affairs Medical Center - San Diego, San Diego, CA (United States); Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ (Brazil); Gasparetto, Emerson; Marchiori, Edson [Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ (Brazil)

    2007-01-15

    To demonstrate the anatomy of the deep and superficial infrapatellar bursae using magnetic resonance (MR) imaging and anatomic correlation in cadavers. MR imaging of the infrapatellar bursae of nine cadaveric knees was performed after ultrasound-guided bursography. The images were compared with those seen on anatomic sectioning. Histologic analysis was obtained in two specimens. The deep infrapatellar bursa (DIB) was visualized in all specimens (n=9) and the superficial infrapatellar bursa (SIB) in five specimens (55%). The mean dimensions of the DIB in the craniocaudal, mediolateral, and anteroposterior planes were respectively 25, 28.7, and 6 mm, and for SIB 19.5, 21.2 and 2.2 mm. A fat apron dividing the DIB was depicted in eight knees (89%). Lateral extension of the DIB beyond the patellar tendon was observed in 100% of cases. Cadaveric analysis depicted a thin septum in the SIB in four of five cases (80%). The DIB is generally present and extends beyond the lateral margin of the patellar tendon. A fat apron partially separating this structure is usual. The SIB is not an unusual finding and may have a septum separating its compartments. (orig.)

  2. Tinjauan Rencana Adopsi IAS 41 pada Perusahaan Agrikultur di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Heny Kurniawati

    2013-05-01

    Full Text Available The purpose of this study is to analyze the adoption plan of IAS 41 Agriculture as a part of IFRS Convergence in Indonesia by investigating the characteristics of biological assets and agriculture produce in public listed companies in Bursa Efek Indonesia (BEI. The methodology used in this study is qualitative approach by investigating financial statements of agricultural public listed companies for the year 2011. Thestudy shows that the biological assets recorded in the public listed companies range from consumable biological assets and bearer biological assets. It also shows that many bearer biological assets need more than one reporting period to be ready to produce other biological assets or agriculture produce to be harvest. According to IAS 41, these biological assets should be recorded using fair value model, however this model will not be appropriate. This findings lead to another questions what is the valuation appropriate for biological assets which have different characteristics.

  3. Flavonoids from Capsella bursa-pastoris and their hepatoprotective activities in vitro

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    Qinge Ma

    Full Text Available ABSTRACT Two new flavonoids (1 and 2, named 4',7-dihydroxy-5-hydroxymethyl-8-prenylflavonoid and 4',7-dihydroxy-5-hydroxymethyl-6,8-diprenylflavonoid, together with seven known flavonoids (3–9 were isolated from the aerial parts of Capsella bursa-pastoris (L. Medik., Brassicaceae, for the first time. The chemical structures of the purified compounds (1–9 were identified by their spectroscopic data and references. Moreover, compounds (1–9 were evaluated for their hepatoprotective activities against D-galactosamine induced toxicity in WB-F344 cells by using a MTT colorimetric method. As a result, compounds 2, 3, 6, and 9 (10 µM exhibited moderate hepatoprotective activities.

  4. Phenolic Glycosides from Capsella bursa-pastoris (L. Medik and Their Anti-Inflammatory Activity

    Directory of Open Access Journals (Sweden)

    Joon Min Cha

    2017-06-01

    Full Text Available A new sesquilignan glycoside 1, together with seven known phenolic glycosides 2–8 were isolated from the aerial parts of Capsella bursa-pastoris. The chemical structure of the new compound 1 was elucidated by extensive nuclear magnetic resonance (NMR data (1H- and 13C-NMR, 1H-1H correlation spectroscopy (1H-1H COSY, heteronuclear single-quantum correlation (HSQC, heteronuclear multiple bond correlation (HMBC, and nuclear overhauser effect spectroscopy (NOESY and HR-FABMS analysis. The anti-inflammatory effects of 1–8 were evaluated in lipopolysaccharide (LPS-stimulated murine microglia BV-2 cells. Compounds 4 and 7 exhibited moderate inhibitory effects on nitric oxide production in LPS-activated BV-2 cells, with IC50 values of 17.80 and 27.91 µM, respectively.

  5. Black-Scholes finite difference modeling in forecasting of call warrant prices in Bursa Malaysia

    Science.gov (United States)

    Mansor, Nur Jariah; Jaffar, Maheran Mohd

    2014-07-01

    Call warrant is a type of structured warrant in Bursa Malaysia. It gives the holder the right to buy the underlying share at a specified price within a limited period of time. The issuer of the structured warrants usually uses European style to exercise the call warrant on the maturity date. Warrant is very similar to an option. Usually, practitioners of the financial field use Black-Scholes model to value the option. The Black-Scholes equation is hard to solve analytically. Therefore the finite difference approach is applied to approximate the value of the call warrant prices. The central in time and central in space scheme is produced to approximate the value of the call warrant prices. It allows the warrant holder to forecast the value of the call warrant prices before the expiry date.

  6. A Rare Case of Deep Digital Flexor Tendinopathy following Centesis of the Navicular Bursa

    Directory of Open Access Journals (Sweden)

    Tim J. Froydenlund

    2017-10-01

    Full Text Available Navicular bursa (NB centesis is a common diagnostic and therapeutic procedure in equine practice. This case report documents the clinical, diagnostic imaging and histological findings in a horse with a suspected iatrogenic deep digital flexor tendon (DDFT injury following centesis of the NB via a modified distal plantar approach (placement of two needles in a weight bearing position. Although it cannot be proven with absolute certainty, the authors believe that this is the first reported case where NB centesis is the likely cause of a DDFT lesion, and with magnetic resonance imaging performed both pre- and post-centesis. With this potential, though rare, complication of the procedure, alternative tendon sparing injection techniques should be considered prior to NB centesis in certain cases.

  7. Synovial Chondromatosis of the Subacromial Bursa Causing a Bursal-Sided Rotator Cuff Tear

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    Julie A. Neumann

    2015-01-01

    Full Text Available Synovial chondromatosis is an uncommon condition, and involvement of the shoulder is even more rare. We report on a 39-year-old female who presented with symptoms, radiographic features, and intraoperative findings consistent with multiple subacromial loose bodies resulting in a partial-thickness, bursal-sided rotator cuff tear of the supraspinatus muscle. She was treated with an arthroscopic removal of loose bodies, complete excision of the subacromial/subdeltoid bursa, acromioplasty, and rotator cuff repair. To our knowledge, this is the first report of arthroscopic treatment for a bursal-sided, partial-thickness rotator cuff tear treated with greater than two-year clinical and radiographic follow-up. We utilized shoulder scores, preoperative and postoperative range of motion, and imaging to assess the results of treatment and surveillance for recurrence in our patient after two-year follow-up.

  8. PERANCANGAN PREDIKSI FINANCIAL DISTRESS PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Rina Sri Wulandari

    2016-12-01

    Full Text Available Krisis ekonomi global menyebabkan banyak perusahaan terutama perusahaan manufaktur mengalami financial distress. Financial distress adalah keadaan dimana perusahaan dalam kondisi kesulitan keuangan sebelum mengalami kebangkrutan. Melakukan prediksi terhadap kondisi keuangan penting dilakukan oleh manajer, auditor serta investor untuk melakukan kebijakan pengambilan keputusan. Semakin akurat prediksi yang dilakukan, maka resiko yang akan ditanggung semakin kecil baik oleh perusahaan maupun oleh investor. Oleh karena itu, penelitian ini bertujuan untuk merancang model prediksi financial distress perusahaan manufaktur yang terdaftar di bursa efek Indonesia. Penelitian ini menggunakan metode Data Envelopment Analysis (DEA. Metode DEA digunakan untuk mengukur efisiensi perusahaan. Perusahaan yang dinyatakan tidak efisien menunjukkan bahwa perusahaan tersebut terancam mengalami kebangkrutan. Rasio-rasio laporan keuangan perusahaan digunakan sebagai data yang akan diolah dengan menggunakan metode DEA.

  9. Signalment Factors, Comorbidity in Behavior Diagnoses in Dogs in Bursa Region, Turkey (2000 - 2004

    Directory of Open Access Journals (Sweden)

    E. Yalcin

    2007-01-01

    Full Text Available The aim of this study was to classify the behaviour problems of dogs reported by owners in the Bursa region. A survey was conducted with the owners of 80 dogs with behaviour problems in 2000 - 2004. The questionnaire consisted of questions related to the demographics of the problems the owners observed in their dogs. Sixty eight dogs were selected from animals referred to the Clinic of the Internal Medicine Department of the Uludag University, Faculty of Veterinary Medicine and 12 dogs were selected at a private kennel. The 68 dogs diagnosed at the clinic as having behaviour problems represented 6.2% of the 1086 patient dogs older than 6 months seen in the same period. Twelve dogs with behaviour problems were selected from a total of 150 dogs at a private kennel. A total of 110 behavioural problems were detected. Some dogs showed more than one behavioural disorder. The classification of the problems was as follows: 65 dogs (59% with aggression, 13 dogs (12% with separation anxiety, 12 dogs (10.5% with phobia of veterinary clinics and high-volume noises such as thunders and fireworks, 12 dogs (10.5% with compulsive disorders (9 dogs with tail chasing, 2 dogs with lick dermatitis, 1 dog with self mutilation, 4 dogs (4% with inappropriate elimination, 2 dogs (2% with coprophagia, and 1 dog (1% with puppy killing, 1 dog (1% with false pregnancy. The breeds most often presented in our study were: German shepherd (19%, Terrier (18%, mixed breed (15%, Anatolian sheepdog (10%. The results of the study showed that behavioural problems are common among dogs in Bursa and aggression ranks first, followed by separation anxiety, phobia and tail chasing.

  10. An Assessment of the Seismicity of the Bursa Region from a Temporary Seismic Network

    Science.gov (United States)

    Gok, Elcin; Polat, Orhan

    2012-04-01

    A temporary earthquake station network of 11 seismological recorders was operated in the Bursa region, south of the Marmara Sea in the northwest of Turkey, which is located at the southern strand of the North Anatolian Fault Zone (NAFZ). We located 384 earthquakes out of a total of 582 recorded events that span the study area between 28.50-30.00°E longitudes and 39.75-40.75°N latitudes. The depth of most events was found to be less than 29 km, and the magnitude interval ranges were between 0.3 ≤ ML ≤ 5.4, with RMS less than or equal to 0.2. Seismic activities were concentrated southeast of Uludag Mountain (UM), in the Kestel-Igdir area and along the Gemlik Fault (GF). In the study, we computed 10 focal mechanisms from temporary and permanents networks. The predominant feature of the computed focal mechanisms is the relatively widespread near horizontal northwest-southeast (NW-SE) T-axis orientation. These fault planes have been used to obtain the orientation and shape factor (R, magnitude stress ratio) of the principal stress tensors (σ1, σ2, σ3). The resulting stress tensors reveal σ1 closer to the vertical (oriented NE-SW) and σ2, σ3 horizontal with R = 0.5. These results confirm that Bursa and its vicinity could be defined by an extensional regime showing a primarily normal to oblique-slip motion character. It differs from what might be expected from the stress tensor inversion for the NAFZ. Different fault patterns related to structural heterogeneity from the north to the south in the study area caused a change in the stress regime from strike-slip to normal faulting.

  11. PEMBENTUKAN PORTOFOLIO OPTIMAL SAHAM-SAHAM PADA PERIODE BULLISH DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Suramaya Suci Kewal

    2013-04-01

    Full Text Available Abstrak: Pembentukan Portofolio Optimal Saham-Saham Pada Periode Bullish Di Bursa Efek Indonesia. Penelitian ini dilakukan dengan tujuan untuk menyusun portofolio optimal saham yang tercatat di Bursa Efek Indonesia dengan menggunakan model indeks tunggal pada periode Bullish. Periode penelitian yang digunakan dalam penelitian ini adalah 2009-2011. Hasilnya adalah tersusunnya sebuah portofolio saham yang terdiri dari empat saham, yaitu ASRI (48,72%, INDF (28,24%, BBNI (16,32%, dan BKSL (6.71%. Hasil pengujian hipotesis pertama menunjukkan bahwa ada perbedaan dalam return saham dari portofolio candidate dibandingkan dengan portofolio noncandidate. Hasil pengujian hipotesis kedua menunjukkan bahwa tidak ada perbedaan dalam risiko saham yang termasuk dalam portofolio candidate dibandingkan dengan portofolio noncandidate. Kata kunci: portofolio optimal, model single-index   Abstract: Establishment of Optimal Portfolio Shares On Bullish Period In Indonesia Stock Exchange. This study was conducted in order to establish an optimal portfolio of stocks listed on the Indonesia Stock Exchange using a single index model on Bullish conditions. Period of research used in this study is 2009-2011. The result is the formation of a stock portfolio consisting of four stocks, namely ASRI (48.72%, INDF (28.24%, BBNI (16.32%, and BKSL (6.71%. The test results of the first hypothesis suggests that there are differences in stock returns a stock portfolio of candidates as compared to the noncandidate portfolio. The results of testing the second hypothesis suggests that there is no difference in the risk of stocks included in candidate portfolios as compared to the noncandidate portfolio. Keywords: optimal portfolios, single-index models

  12. Histomorphology of bursa of Fabricius: effects of stock densities on commercial broilers

    Directory of Open Access Journals (Sweden)

    EC Muniz

    2006-12-01

    Full Text Available During the past few years, there has been considerable interest on the effects of stocking density on broiler behavior and immunity. Stress may cause immunodeficiency by affecting cell and humoral responses, as well as body weight decrease, and foot-pad dermatitis. The aim of this study was to study histomorphological changes of the bursa of Fabricius in broilers submitted to three different stocking densities (10, 15, and 20 birds/m² from one to 42 days of age. Three birds from each group were sacrifieced on days 7 and 42. The bursa was collected, fixed, and processed for histomorphometric assessment using a Kontrom KS 400 image analyzer. Data were analyzed by Biostat 3.0 (Tukey Test. The results of average cortical area percentage in bursal follicles of 6-week-old birds were 45.12a (10 birds/m², 30.43b (15 birds/m², and 23.77b (20 birds/m². Average body weight was 2.58a kg (10 birds/m², 2.56a Kg (15 birds/m², and 2.47b Kg (20 birds/m², respectively. The percentage of foot-pad dermatitis in 6-week-old birds was 3.33a (10 birds/m², 17.76b (15 birds/m², and 49.17c (20 birds/m². These differences were statistically significant at a P<0.05 level. Under these experimental conditions,, it was concluded that the best stocking density to produce broilers is between 10-15 birds per square meter.

  13. The role of the thymus for maturation of transferred bursa cells into immuno-competent B cells in chickens treated with cyclophosphamide

    International Nuclear Information System (INIS)

    Hirota, Y.; Bito, Y.

    1978-01-01

    Chickens injected with cyclophosphamide and X-ray irradiated in the newly hatched period were immunized with a mixture of sheep red blood cells, Brucella abortus and Salmonella pullorum at 4, 5 and 6 weeks of age, and were examined for serum antibody titres, serum immunoglobulin concentration and bursal and splenic structures at 7 weeks of age. The neonatal treatments suppressed completely or almost completely antibody responses, immunoglobulin production and formation of bursal follicles and splenic germinal centres. The transplantation of bursa cells into the chickens immunologically impaired by the treatments restored these functions and structures. In contrast, the transfer of bursa cells into chickens thymectomized, cyclophosphamide-treated and X-ray irradiated did not result in efficient restoration of the bursa-dependent immune system; 10-day-old bursa cells hardly restore the system, although 4-week-old bursa cells did so slightly. The chickens thymectomized, cyclophosphamide-treated, X-ray irradiated and re-populated with 10-day-old bursa cells were examined for the existence of functional B cells with the use of a syngeneic cell transfer system. The experiments verified that immunocompetent B cells had not developed in the chickens thus treated. (author)

  14. Gambaran Patologi Bursa Fabricius Embrio Ayam Pascavaksinasi Gumboro Secara In Ovo Menggunakan Vaksin Lokal dan Komersial (PATHOLOGIC DESCRIPTION OF BURSA FABRICIUS CHICKEN EMBYROS AFTER IN OVO VACCINATED WITH LOCAL AND COMMERSIAL GUMBORO VACCINES

    Directory of Open Access Journals (Sweden)

    Sutiastuti Wahyuwardani

    2015-10-01

    Full Text Available Bursa Fabricius is a target organ of gumboro virus infection which is often damaged after vaccinationusing hot intermediate gumboro live vaccine. The purpose of this study was to assess pathologic effect oflocal and commercial gumboro vaccines . As many as 45 embryo chicken eggs at nine day old were used inthis research, then grouped into three groups of 15 embryos chicken eggs each, these were: Embryo chickeneggs without vaccination (Group I, vaccinated with IBD intermediate plus commercial vaccine (Group IIand IBD intermediate plus local vaccine (Group III. Vaccinations were done at 14 days old. All groups thenterminated each three embryos at 12 hours, 1, 2, 3 days post vaccination. The results showed that pathologicanatomic lesions could not be detected. Whereas pathologic lesions were detected in the group that werevaccinated with intermediate plus local IBD observed more severe than in the group that vaccinated withintermediate plus commercial IBD. Lesions such as edema, hemorrhages, necrosis of lymphoid cells wereobserved microscopically in embryo at 12 hours, 1, 2 and 3 days post vaccination in Group II and group III.The lesions were more severe at two days post vaccination causing some lymphoid follicles disappeared at three days post vaccination. However, they were not detected again in the bursa Fabricius three days afterhatching. Cells containing antigens of gumboro were detected in the bursa Fabricius of chicken embryo atone day until three days post vaccination, then disappeared after three days post hatch. It was concludedthat pathologic description of bursa fabricius showed that virus vaccines used for vaccinated IBD in ovowere still virulent, that can cause histopathologic lesions. The viruses are suggested to be more attenuatedbefore using as vaccine in ovo.

  15. A Comparative History of Gender and Factory Labour in Ottoman Bursa and Colonial Bombay, c.1850-1910

    OpenAIRE

    Yildiz, Hatice

    2017-01-01

    This thesis explores the gendered dynamics of industrialisation in the late Ottoman Empire and British India. It examines the ways in which gendered notions of skill, waged work, domesticity and technology shaped employment patterns, labour processes and politics in silk factories in Bursa and cotton mills in Bombay between 1850 and 1910. The project undermines the notion that women's labour was incidental to the development of large-scale factory enterprise in Ottoman and Indian lands. I arg...

  16. Aplikasi Analisis Diskriminan Dalam Penentuan Rasio-Rasio Keuangan Yang Mempengaruhi Tingkat Kesehatan Perusahaan Pada Bursa Efek Indonesia

    OpenAIRE

    Zulham, Muhammad

    2011-01-01

    Discriminant Analysis is a multivariate analysis which used to classificating experiment object to a group whom have variables certainly and make a predictive model. This model must have dependent (non metric) variable like categorical or nominal data and have independent (metric) variable like interval or ratio. Both of them must be normal distribution. In this research, discriminant analysis used to choosing financial ratios which make a influence of company healthness level in Bursa Efek I...

  17. Investigating the Intraday Interdependence Between the Index Futures and Stock Index at Different Time Scales : Evidence from Bursa Malaysia

    OpenAIRE

    Kunle-Ogunlusi, Nene

    2016-01-01

    This study examines the intraday dynamic association between the Bursa Malaysia futures and its underlying spot markets. Specifically, the study focuses on the price discovery concept and volatility transmission mechanism between the FKLI futures and the FBMKLC index using three high-frequency (10 minutes, 30 minutes and 1 hour time-scales) intraday data sets over two sample periods covering June 04, 2013 to September 30, 2013 and May 12, 2015 to June 10, 2015. The cointegration tests, VECM, ...

  18. NEIGHBORHOOD NAMES OF BURSA IN THE WRITINGS OF GAZZIZÂDE ABDULLATIF EFENDI - GAZZİZÂDE ABDÜLLATİF EFENDİ’NİN KALEMİNDEN BURSA MAHALLE ADLARI

    Directory of Open Access Journals (Sweden)

    Ayşe Nur SIR DÜNDAR

    2015-08-01

    Full Text Available During the Ottoman period, cities were administrative units representing the existence of central authority and hegemony. It collected several activities and services within the domain and constituted a whole with its sub units in terms of administrative and civil duties. The development of city was dependent on the development of common life areas, which are neighborhoods. It was possible to see this structure, which is the basis of Ottoman urbanism, in Bursa, Edirne, Istanbul and some other Anatolian cities. Particularly Bursa has rapidly grown within the two centuries following the conquest and displayed a fine example of urbanization as a historical and cultural center. The idle fields in the city were allocated to Turkish tribes, new neighborhoods were established and the nearby villages were transformed into neighborhoods, increasing the total number of neighborhoods in the city. Beside this physical development, the newly established neighborhoods were given Turkish names as the old neighborhoods’ names were also made Turkish. Within this context, it was important to create a neighborhood in the localization of Bursa and the names given to those neighborhoods were also important. Because the names of places are the living documents for the habitation (settlement history of a nation. Studies to be conducted on neighborhood names are the research subjects of several social sciences such as sociology and anthropology and also the linguistics. Evaluation of the names of places phonetically and morphologically will contribute to the development of toponomy, which is an important branch of linguistics. This study has reviewed the neighborhood names in Hulâsatü’l-Vefeyât, a work of Gazzizâde Abdüllatif Effendi, which is considered as an urban monograph among the monographs on Bursa. The review was conducted on the copy of the author which was registered in Süleymaniye Library Assad Effendi, numbers 2257. First, information is provided

  19. Estimation of stochastic volatility with long memory for index prices of FTSE Bursa Malaysia KLCI

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Kho Chia; Kane, Ibrahim Lawal; Rahman, Haliza Abd [Department of Mathematical Sciences, Faculty of Science, Universiti Teknologi Malaysia, 81310, Johor Bahru (Malaysia); Bahar, Arifah [UTM Centre for Industrial and Applied Mathematics (UTM-CIAM), Universiti Teknologi Malaysia, 81310, Johor Bahru and Department of Mathematical Sciences, Faculty of Science, Universiti Teknologi Malaysia, 81310, Johor Bahru (Malaysia); Ting, Chee-Ming [Center for Biomedical Engineering, Universiti Teknologi Malaysia, 81310, Johor Bahru (Malaysia)

    2015-02-03

    In recent years, modeling in long memory properties or fractionally integrated processes in stochastic volatility has been applied in the financial time series. A time series with structural breaks can generate a strong persistence in the autocorrelation function, which is an observed behaviour of a long memory process. This paper considers the structural break of data in order to determine true long memory time series data. Unlike usual short memory models for log volatility, the fractional Ornstein-Uhlenbeck process is neither a Markovian process nor can it be easily transformed into a Markovian process. This makes the likelihood evaluation and parameter estimation for the long memory stochastic volatility (LMSV) model challenging tasks. The drift and volatility parameters of the fractional Ornstein-Unlenbeck model are estimated separately using the least square estimator (lse) and quadratic generalized variations (qgv) method respectively. Finally, the empirical distribution of unobserved volatility is estimated using the particle filtering with sequential important sampling-resampling (SIR) method. The mean square error (MSE) between the estimated and empirical volatility indicates that the performance of the model towards the index prices of FTSE Bursa Malaysia KLCI is fairly well.

  20. Estimation of stochastic volatility with long memory for index prices of FTSE Bursa Malaysia KLCI

    Science.gov (United States)

    Chen, Kho Chia; Bahar, Arifah; Kane, Ibrahim Lawal; Ting, Chee-Ming; Rahman, Haliza Abd

    2015-02-01

    In recent years, modeling in long memory properties or fractionally integrated processes in stochastic volatility has been applied in the financial time series. A time series with structural breaks can generate a strong persistence in the autocorrelation function, which is an observed behaviour of a long memory process. This paper considers the structural break of data in order to determine true long memory time series data. Unlike usual short memory models for log volatility, the fractional Ornstein-Uhlenbeck process is neither a Markovian process nor can it be easily transformed into a Markovian process. This makes the likelihood evaluation and parameter estimation for the long memory stochastic volatility (LMSV) model challenging tasks. The drift and volatility parameters of the fractional Ornstein-Unlenbeck model are estimated separately using the least square estimator (lse) and quadratic generalized variations (qgv) method respectively. Finally, the empirical distribution of unobserved volatility is estimated using the particle filtering with sequential important sampling-resampling (SIR) method. The mean square error (MSE) between the estimated and empirical volatility indicates that the performance of the model towards the index prices of FTSE Bursa Malaysia KLCI is fairly well.

  1. Waste-heat recovery potential in Turkish textile industry. Case study for city of Bursa

    Energy Technology Data Exchange (ETDEWEB)

    Pulat, E.; Etemoglu, A.B.; Can, M. [Uludag University, Faculty of Engineering and Architecture, Mechanical Engineering Department, Gorukle, TR-16059, Bursa (Turkey)

    2009-04-15

    Textile sector of Turkey has a large production capacity and it is one of the important sectors. Many industrial heating processes generate waste energy in textile industry. Therefore, there is a tremendous waste-heat potential to utilize in textile applications. This study assesses the potential of waste-heat obtained from particularly dyeing process at textile industry in Bursa where textile center of Turkey. Energy consumptions could be decreased by using of waste-heat recovery systems (WHRSs). A thermodynamic analysis is performed in this study. An exergy-based approach is performed for optimizing the effective working conditions for WHRSs with water-to-water shell and tube heat exchanger. The payback period is found to be less than 6 months. The variations of the parameters which affect the system performance such as waste-water inlet temperature, mass flow rate, cooling water inlet pressure and dead state conditions are examined respectively. The results of the analysis show that the exergy destruction rate and economical profit increase with increasing of mass flow rate of the waste water. Similarly, exergy destruction rate, effectiveness and economical profit increase while the second law efficiency decreases as the waste-water inlet temperature increases. (author)

  2. Estimation of stochastic volatility with long memory for index prices of FTSE Bursa Malaysia KLCI

    International Nuclear Information System (INIS)

    Chen, Kho Chia; Kane, Ibrahim Lawal; Rahman, Haliza Abd; Bahar, Arifah; Ting, Chee-Ming

    2015-01-01

    In recent years, modeling in long memory properties or fractionally integrated processes in stochastic volatility has been applied in the financial time series. A time series with structural breaks can generate a strong persistence in the autocorrelation function, which is an observed behaviour of a long memory process. This paper considers the structural break of data in order to determine true long memory time series data. Unlike usual short memory models for log volatility, the fractional Ornstein-Uhlenbeck process is neither a Markovian process nor can it be easily transformed into a Markovian process. This makes the likelihood evaluation and parameter estimation for the long memory stochastic volatility (LMSV) model challenging tasks. The drift and volatility parameters of the fractional Ornstein-Unlenbeck model are estimated separately using the least square estimator (lse) and quadratic generalized variations (qgv) method respectively. Finally, the empirical distribution of unobserved volatility is estimated using the particle filtering with sequential important sampling-resampling (SIR) method. The mean square error (MSE) between the estimated and empirical volatility indicates that the performance of the model towards the index prices of FTSE Bursa Malaysia KLCI is fairly well

  3. Puncture wounds into the navicular bursa of the horse: role of radiographic evaluation

    International Nuclear Information System (INIS)

    Richardson, G.L.; O'Brien, T.R.

    1985-01-01

    Radiography was used to evaluate 32 horses presented for puncture wounds into the navicular bursa. At the initial radiographic examination, 21 horses had no radiographic signs of osteomyelitis, while 11 did. The mean-time interval between injury and radiographic examination was 20.6 days for horses without evidence of osteomyelitis and 59.3 days for those with evidence of osteomyelitis. Radiographic signs of osteomyelitis of the navicular bone included flexor cortical destruction and irregularity of the flexor surface. Other abnormalities included pathologic fracture of the navicular bone, subluxation of the distal interphalangeal joint, or secondary joint disease. The lateromedial and palmaroproximal-palmarodistal oblique projections were most useful for identifying abnormalities of the navicular bone. There was a high correlation between horses that had positive presurgical radiographic signs and surgical findings. However, approximately 50% of horses that had negative radiographic findings initially had positive surgical findings. Ten of 21 horses with negative radiographic findings on initial examination had evidence of bony lesions when reevaluated from 3 weeks to 6 years later. Nine of 11 horses with radiographic signs of osteomyelitis on initial radiographic examination were euthanatized or had an unsatisfactory outcome. Seven of 10 horses with radiographic signs on reexamination were euthanatized. Thirteen of 20 horses with positive surgical findings for navicular bone infection were euthanatized or had an unsatisfactory outcome

  4. Evaluation of radon concentration in well and tap waters in Bursa (Turkey)

    International Nuclear Information System (INIS)

    Akar Tarim, U.; Gurler, O.; Akkaya, G.; Kilic, N.; Yalcin, S.; Kaynak, G.; Gundogdu, O.

    2012-01-01

    222 Rn measurements in water samples collected from 27 wells and 19 taps that were supplied from the investigated wells were conducted using the AlphaGUARD PQ 2000PRO radon gas analyser at sites across several geologic formations within the city of Bursa (Turkey). The measured radon concentrations ranged from 1.46 to 53.64 Bq l -1 for well water and from 0.91 to 12.58 Bq l -1 for tap water. Of the 27 sites sampled, only 7 had radon levels above the safe limit of 11.1 Bq l -1 recommended by the USEPA. In general, all determined concentrations were well below the 100 Bq l -1 revised reference level proposed by the European Union. These values of radon concentrations in water samples are compared with those reported from other countries. Doses resulting from the consumption of these waters were calculated. The minimum and the maximum annual mean effective doses due to 222 Rn intake through water consumption were 0.02 μSv a -1 and 1.11 μSv a -1 , respectively. (authors)

  5. Calcaneus, calcaneal tendon and retrocalcaneal bursa. Historical overview and plea for an accurate terminology.

    Science.gov (United States)

    Kachlik, D; Musil, V; Vasko, S; Klaue, K; Stingl, J; Baca, V

    2010-01-01

    Diseases and injuries of several specific structures in the heel region have been an enduring focus of medicine: The anatomical terminology of many of these structures has not been established until recently. The aim of the study was a historical analysis of the advances of anatomical terminology of three selected morphological units in the heel region--the Achilles tendon, calcaneus and retrocalcaneal bursa. It starts with a critical evaluation of the mythological eposes, the Illiad and Odyssey, describing the exploits of heroes in the Trojan war, followed by a review of relevant terms used for the designation of selected heel structures in the Middle Ages as well as in the 18" and 19" centuries. Principal versions of Latin anatomical terms used for the denotation of the mentioned structures are discussed. Recently applicable Latin terms and their recommended English synonyms, according to the latest version of Terminologia Anatomica (1998) are summed up. It surveys examples of "not very appropriate" terms, which are frequently used in clinical literature. The authors consider the use of official anatomical terms (both Latin and English) as an important step for the improvement of the clinical expressions and formulations.

  6. The Tail Exponent for Stock Returns in Bursa Malaysia for 2003-2008

    Science.gov (United States)

    Rusli, N. H.; Gopir, G.; Usang, M. D.

    2010-07-01

    A developed discipline of econophysics that has been introduced is exhibiting the application of mathematical tools that are usually applied to the physical models for the study of financial models. In this study, an analysis of the time series behavior of several blue chip and penny stock companies in Main Market of Bursa Malaysia has been performed. Generally, the basic quantity being used is the relative price changes or is called the stock price returns, contains daily-sampled data from the beginning of 2003 until the end of 2008, containing 1555 trading days recorded. The aim of this paper is to investigate the tail exponent in tails of the distribution for blue chip stocks and penny stocks financial returns in six years period. By using a standard regression method, it is found that the distribution performed double scaling on the log-log plot of the cumulative probability of the normalized returns. Thus we calculate α for a small scale return as well as large scale return. Based on the result obtained, it is found that the power-law behavior for the probability density functions of the stock price absolute returns P(z)˜z-α with values lying inside and outside the Lévy stable regime with values α>2. All the results were discussed in detail.

  7. ANALISIS PENGARUH EVA DAN MVA TERHADAP RETURN SAHAM PADA INDUSTRI PROPERTI DI BURSA EFEK INDONESIA PERIODE 2007-2012

    Directory of Open Access Journals (Sweden)

    Ryan Pahlawan

    2015-04-01

    Full Text Available Abstrak: Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis: (1 pengaruh Economic Value Added (EVA terhadap return saham (2 pengaruh Market Value Added (MVA terhadap return saham (3 pengaruh Economic Value Added (EVA dan Market Value Added (MVA terhadap return saham antara variabel kinerja keuangan industri properti di Bursa Efek Indonesia pada periode 2007-2012. Kegunaan teoritis adalah untuk memberikan kontribusi tentang pengetahuan manajemen keuangan, yang dapat digunakan sebagai acuan untuk penelitian berikutnya kinerja keuangan terutama tentang industri properti di Bursa Efek Indonesia. Kegunaan praktis adalah untuk mengetahui pengaruh tingkat Economic Value Added (EVA dan Market Value Added (MVA terhadap kinerja keuangan untuk kontribusi memberi kepada manajemen properti umum dalam mengelola variabel kinerja industri properti Bursa Efek Indonesia.Penelitian ini menggunakan data sekunder yang dikumpulkan dari data Bursa Efek Indonesia, dan Departemen Riset menurut sifat laporan keuangan pada periode 2007-2012. Sampel adalah 54 variabel dan dianalisis dengan regresi berganda metode statistik linier. Total nilai determinasi adalah 0,368, artinya ini adalah 36,8% informasi dalam data dapat dijelaskan oleh model dan 63,2% di bawah variabel lain dan error. Kesimpulan dari penelitian ini adalah: (1 Variabel Economic Value Added (EVA berpengaruh positif terhadap return saham; (2 Variabel Market Value Added (MVA memiliki pengaruh negatif terhadap Return Saham; Mengacu pada kesimpulan penelitian diatas maka disarankan adalah: (1 Dioptimalkan Economic Value Added (EVA untuk mencapai pendapatan dan keuntungan dari return saham (2 Mengelola Variabel Market Value Added (MVA pada kondisi baik untuk menjaga stabilitas keuangan dan mendapatkan dipercaya dari investor Bursa Efek Indonesia (3 Fokus ke Manajemen Risiko, Jasa, perusahaan Visi & Misi, dan Active keterampilan dan pengetahuan karyawan perusahaan yang lebih tinggi untuk

  8. ANALISIS VARIABEL YANG BERPENGARUH TERHADAP SPREAD HARGA SAHAM PADA INDUSTRI MANUFAKTUR DI BURSA EFEK JAKARTA

    Directory of Open Access Journals (Sweden)

    SRI UTAMI ADY

    2012-05-01

    Full Text Available ABSTRAK Spread adalah selisih harga jual dan harga beli saham di pasar modal. Harga jual dan harga beli ditentukan oleh Broker. Besar kecilnya spread dipengaruhi oleh dua faktor yaitu ketidakseimbangan informasi dan persaingan di antara pelaku pasar. Semakin tinggi ketidakseimbangan informasi diantara pelaku pasar maka semakin besar spread. Dan semakin kuat persaingan di pasar modal maka harga jual semakin rendah dan harga beli semakin tinggi sehingga spread mengecil. Pengumuman dividen diharapkan dapat memberikan informasi ke pasar modal dan mengurangi informasi asimetri sehingga spread mengecil. Sebagai proxy dari informasi digunakan variabel kapitalisasi pasar dan lama terdaftar. Tujuan penelitian ini adalah untuk mengetahui : (1 pengaruh dari variabel-variabel dividend yield, volume perdagangan, varian return, harga saham, kapitalisasi pasar dan lama terdaftar terhadap spread baik secara simultan ataupun parsial. (2 Manakah diantara variabel-variabel tersebut yang paling berpengaruh terhadap spread Penelitian dilakukan pada 25 perusahaan manufaktur yang terdaftar di Bursa Efek Jakarta (BEJ sebagai sampel penelitian. Teknik pengambilan sampel yang digunakan adalah purposive, yaitu pada perusahaan manufaktur yang membayarkan cash dividend dan aktif diperdagangkan pada tahun 1999. Penelitian menggunakan data harian saham di Bursa Efek Jakarta (BEJ pada periode Januari sampai dengan Desember 1999, metode analisis yang digunakan adalah Regresi Linier Berganda. Hasil penelitian menyimpulkan bahwa : (1 Variabel dividend yield dan volume perdagangan mempunyai pengaruh negatif signifikan, varian return berpengaruh positif signifikan. (2 Harga saham berpengaruh negatif tidak signifikan dan lama terdaftar berpengaruh positif signifikan. (3 Terdapat multikolinier antara volume perdagangan dan kapitalisasi pasar sehingga kapitalisasi pasar dikeluarkan dari model. (4 Varian return adalah variabel yang paling berpengaruh terhadap spread. Kemungkinan hasil

  9. Solitary Osteochondroma of the Ventral Scapula Associated with Large Bursa Formation and Pseudowinging of the Scapula: A Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    Kiyohisa Ogawa

    2018-01-01

    Full Text Available Osteochondroma (OC is the most common benign bone tumor and may occur on any bone in which endochondral ossification develops. Although scapular OC accounts for less than 5% of the cases of solitary OC, OC is the most common lesion among the tumors and tumor-like lesions of the scapula. OC that develops near the medial scapular border easily causes friction with the ribcage; hence, almost half the number of cases of OC associated with marked bursa formation develops in the ventral scapula. We report a case of a 27-year-old female with a painful OC of the ventral scapular surface associated with large bursa formation and pseudowinging of the scapula. After l2 years of follow-up with magnetic resonance imaging, we confirm that the accompanied bursa left at surgery disappears.

  10. ECONOMY AND CULTURE IN TRANSITIONS: A COMPARATIVE STUDY OF TWO ARCHITECTURAL HERITAGE SITES OF BAZARS AND HANS OF BURSA AND DHAKA

    Directory of Open Access Journals (Sweden)

    Tasleem Shakur

    2013-11-01

    Full Text Available Chawkbazar in Dhaka and Covered Bazaar in Bursa are two unique examples showing the contradiction among the traditional and the contemporary life-styles and their reflections on space uses and architecture. The first example in Dhaka is one of the prime icons of Mughal architecture in Bangladesh, whereas the second one in Bursa is the first example of the typical nucleus of traditional Ottoman city. Based on these two case studies in Dhaka (Bangladesh and Bursa (Turkey, this paper attempts to illustrate how the emerging cultures and spaces are continuously being either negotiated or contested with their adjacent historic sites (Shakur, 2005. This comparative research between two similar historical sites (Mughal and Ottoman but miles apart geographically is intended to understand the commonalities in its economic, social, cultural aspects through its transformation from the historic to the contemporary period. It highlights the socio-economic and cultural transformation and its implications for future conservation and development.

  11. Atmospheric dry deposition fluxes of trace elements measured in Bursa, Turkey

    International Nuclear Information System (INIS)

    Tasdemir, Yuecel; Kural, Can

    2005-01-01

    Trace element dry deposition fluxes were measured using a smooth, greased, knife-edge surrogate surface (KSS) holding greased Mylar strips in Bursa, Turkey. Sampling program was conducted between October 2002 and June 2003 and 46 dry deposition samples were collected. The average fluxes of crustal metals (Mg, Ca, and Fe) were one to four orders of magnitude higher than the fluxes of anthropogenic metals. Trace element fluxes ranged from 3 (Cd) to 24 230 (Ca) μg m -2 d -1 . The average trace element dry deposition fluxes measured in this study were similar to those measured in other urban areas. In addition, ambient air samples were also collected simultaneously with flux samples and concentrations of trace elements, collected with a TSP sampler, were between 0.7 and 4900 ng m -3 for Cd and Ca, respectively. The overall trace element dry deposition velocities, calculated by dividing the fluxes to the particle phase concentrations ranged from 2.3±1.7 cm s -1 (Pb) to 11.1±6.4 cm s -1 (Ni). These values are in good agreement with the values calculated using similar techniques. The anthropogenic and crustal contributions were estimated by employing enrichment factors (EFs) calculated relative to the average crustal composition. Low EFs for dry deposition samples were calculated. This is probably due to contamination of local dust and its important contribution to the collected samples. - Mechanical turbulence has an important influence on re-suspension and dry deposition of trace elements in an urban area

  12. PENGARUH PENERBITAN OPINI GOING CONCERN PADA PERGANTIAN AUDITOR PADA PERUSAHAAN YANG TERDAFTAR PADA BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Made Wahyu Adhiputra

    2015-10-01

    Full Text Available Tujuan penelitian ini adalah untuk membuktikan secara empiris pengaruh opini going concern pada pergantian auditor, kemampuan ketepatwaktuan pelaporan keuangan dan komite audit memoderasi pengaruh opini going concern pada pergantian auditor, dan pengaruh interaksi opini going concern, ketepatwaktuan pelaporan keuangan, dan komite audit pada pergantian auditor. Populasi yang digunakan dalam penelitian ini adalah seluruh perusahaan yang terdaftar di Bursa Efek Indonesia tahun 2011-2013 dengan metode pemilihan sampel menggunakan purposive sampling. Pengujian hipotesis dilakukan dengan menggunakan regresi logistik binari dengan dua model penelitian. Hasil penelitian menunjukkan penerbitan opini going concern berpengaruh positif pada kemungkinan terjadinya pergantian auditor. Ketepatwaktuan pelaporan keuangan dan komite audit tidak memoderasi pengaruh penerbitan opini going concern pada kemungkinan terjadinya pergantian auditor. Hasil penelitian juga menunjukkan interaksi penerbitan opini going concern, ketepatwaktuan pelaporan keuangan dan komite audit tidak berpengaruh pada kemungkinan perusahaan melakukan pergantian auditor.The purpose of this study are to determine the effect of going concern opinion at the auditor switching, to determine the ability of timeliness of financial reporting and the audit committee to moderate the effect of going concern opinion at the auditor switching, and to determine the effect of the interaction of the going concern opinion, timeliness of financial reporting and the audit committee at the auditor switching. The population used in this study are all companies listed on the Indonesia Stock Exchange in 2011-2013 with selection method sample using purposive sampling. Hypothesis testing is performed using binary logistic regression. The results showed the issuance of going concern opinion has a positive effect on the possibility of auditor switching. Timeliness of financial reporting and the audit committee did not

  13. DETERMINAN PENGUNGKAPAN SUSTAINABILITY REPORT PADA PERUSAHAAN YANG TERDAFTAR DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Sri Wiwik Anggiyani

    2017-05-01

    Full Text Available Penelitian ini bertujuan untuk memperoleh bukti secara empiris pengaruh tipe industri, independensi komite audit, ukuran perusahaan, rasio leverage (DER, rasio profitabilitas (ROA terhadap pengungkapan sustaianbility report. Populasi dalam penelitian ini adalah seluruh perusahaan yang terdaftar di Bursa Efek Indonesia (BEI tahun 2009-2013. Teknik pengambilan sampel dilakukan dengan menggunakan metode purposive sampling yang menghasilkan 26 dari tahun 2009 – 2013. Alat analisis untuk menguji hipotesis adalah path analysis dengan software AMOS versi 21. Hasil penelitian ini menunjukkan bahwa tipe industri berpengaruh negatif dan signifikan terhadap ukuran perusahaan, selanjutnya tipe industri berpengaruh negatif dan signifikan terhadap rasio leverage, kemudian ukuran perusahaan berpengaruh positif dan signifikan terhadap rasio leverage. Rasio leverage berpengaruh negatif dan signifikan terhadap profitabilitas dan rasio leverage berpengaruh negatif dan signifikan terhadap pengungkapan sustainability report. Juga ukuran perusahaan yang berpengaruh positif dan signifikan terhadap pengungkapan sustainability report. The aim of this study was to obtain empirical evidence of the impact of the type of industry, the independency audit committee, company size, leverage ratio (DER, profitability ratio (ROA to the sustainability report. The population on this research is all the company that registered in Indonesia Stock Exchange (IDX on 2009-2013. The sampling technique was conducted using purposive sampling method. Base on this method, obtained the sample of 26 companies since 2009-2013. This research used path analysis software with AMOS version 21 as the instrument to test the hypothese. The result of this research shows that the type of the industry negatively affect and significant to the company size. Next, the type of the industry negatively affect and significant to leverage ratio, then company’s standard positively affect and significant to

  14. FRAUD DETECTION LAPORAN KEUANGAN PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK NDONESIA

    Directory of Open Access Journals (Sweden)

    Indarti Inova Fitri Siregar Nurhayani Lubis

    2016-03-01

    Full Text Available Abstrak : Penelitian ini bertujuan untuk menganalisis pendeteksian laporan keuangan dengan menggunakan Leverage, Financial Stability, dan Financial Targets, studi Empiris pada Perusahaan Manufaktur yang terdaftar di Bursa Efek Indonesia untuk tahun laporan 2012 sampai dengan 2014. Mengingat pentingnya peran yang dimiliki oleh laporan keuangan, maka hanya laporan keuangan berkualitas dan terbebas dari salah saji material baik yang disengaja (fraud maupun yang tidak disengaja (error yang dapat dipercaya sebagai sumber informasi untuk pengambilan keputusan. Untuk itu sebagai tujuan jangka panjangnya adalah agar setiap perusahaan dapat mendeteksi laporan keuangannya secara dini oleh bagian internal kontrol atau bagian internal audit perusahaannya agar terhindar dari kemungkinan kecurangan penyajian Laporan Keuangan.Adapun objek yang menjadi penelitian ini Laporan Keuangan yang terdaftar di Bursa Efek Indonesia. Populasi dalam penelitian ini adalah Perusahaan Manufaktur yang terdaftar di Bursa Efek Indonesia untuk tahun laporan 2012 sampai dengan 2014.  Sampel pada penelitian ini dipilih berdasarkan metode  purposive sampling dengan  jumlah  populasi  sebanyak  134  perusahaan  dan  sampel  sebanyak  20 perusahaan.  Metode  analisis  yang  digunakan  adalah  analisis  regresi  berganda dengan program SPSS versi 20. Teknik analisis yang digunakan pada penelitian ini  adalah  analisis  statistik  deskriptif,  uji  asumsi  klasik,  uji  hipotesis  F-statistik untuk  menguji  pengaruh  secara  bersama-sama  dengan  tingkat  kepercayaan  5% serta  menggunakan  t-statistik  untuk  menguji  koefisien  regresi  parsial. Penelitian ini dilakukan untuk menganalisis seberapa besar pengaruh Leverage, Financial stability pressure, dan Financial Targets terhadap Fraud Detection pada pelaporan keuangan dengan menggunakan Manajemen Laba Riil.Hasil penelitian  ini  menunjukkan  bahwa  secara  simultan  Leverage

  15. Retrieval of a self-expanding metal stent after migration and incorporation in the omental bursa, using a gastroscopic-transgastric laparoscopic rendezvous technique.

    Science.gov (United States)

    Patrzyk, Maciej; Dierzek, Przemyslaw; Glitsch, Anne; Paul, Hartmut; Heidecke, Claus-Dieter

    2015-01-01

    Endoscopic drainage is a widely used treatment for pancreatic pseudocysts. Drainage-related complications may be related directly to the procedure or may occur later as stents migrate or erode into adjacent structures. Migration of a self-expanding metal stent into peritoneal cavity and incorporation in the omental bursa is rare. When endoscopic retrieval fails a combined laparoscopic-endoscopic (rendezvous technique) approach offers an alternative to open surgery. We report a case of successful gastroscopic-transgastric laparoscopic removal of a stent that was dislocated into the omental bursa after a ½ year observation period.

  16. Retrieval of a self-expanding metal stent after migration and incorporation in the omental bursa, using a gastroscopic-transgastric laparoscopic rendezvous technique

    Directory of Open Access Journals (Sweden)

    Maciej Patrzyk

    2015-01-01

    Full Text Available Endoscopic drainage is a widely used treatment for pancreatic pseudocysts. Drainage-related complications may be related directly to the procedure or may occur later as stents migrate or erode into adjacent structures. Migration of a self-expanding metal stent into peritoneal cavity and incorporation in the omental bursa is rare. When endoscopic retrieval fails a combined laparoscopic-endoscopic (rendezvous technique approach offers an alternative to open surgery. We report a case of successful gastroscopic-transgastric laparoscopic removal of a stent that was dislocated into the omental bursa after a ΍ year observation period.

  17. WORK AND ORGANIZATION IN THE OTTOMAN EMPIRE: NOTES ON THE TRADE GUILDS OF SIXTEENTH- AND SEVENTEENTH CENTURY BURSA

    Directory of Open Access Journals (Sweden)

    Dr. Ömer DÜZBAKAR

    2008-09-01

    Full Text Available The primary function of artisans’ and commercial guilds was toperform and maintain daily activities of economic life in harmony andsocial consolidation with minimal conflict. Thus, the state would get ridof the heavy burden of bureaucratic procedures on the one hand, and yetwould also have the guilds yield to a standard of production as well aseliminate unfair competition through their autonomous internal workingson the other. Through such an auto-control mechanism the guilds wouldsolve their own problems with minimum resort to administrative andjudicial institutions. This article sheds light on the origins of Ottomanguild system, workings of trade guilds of Bursa and the supervisoryfunctions of their managers as well as on the various roles and activitiesplayed by the guilds in imperial public life. It also examines the conflictsof interest, unruly acts and forms of resolution taking place within andacross the guilds, with or without having recourse to judicial and otherimperial authorities. The study is based on a set of original historical documents surveyed from the Shari’a Court records of Bursa in the 16thand 17th centuries.

  18. Influence of sex, age, and fasting on blood parameters and body, bursa, spleen and yolk sac weights of broiler chicks

    Directory of Open Access Journals (Sweden)

    DL Pires

    2007-12-01

    Full Text Available The effects of water and feed fasting for 24, 48 and 72 hours post-hatching on blood parameters (mean corpuscular volume, MCV; red blood-cell, RBC; hematocrit, HCT; hemoglobin, HGB; plasma glucose, CGP; plasma total protein, PP, and differential leukocytes count, and on body, liver, spleen, bursa, and yolk sac weights were analyzed. Erythrogram data were obtained with a blood cell counter. Total plasma protein and plasma glucose were determined by using the Bradford method (1976 and a glucose PAP liquiform kit (Labtest, cat. n. 84, respectively. Specific leukocyte counts were carried out on blood smears stained with Rosenfeld solution. According to the obtained data, water and feed post-hatching fasting reduced MCV values, which also were lower in males than that in females. Fasting for 48 hours promoted an increase in PP, while fasting for 72 hours reduced HCT. Chicks submitted to fasting presented lower body weights as compared to fed chicks, but their liver weight did not increase between 48 and 72 hours of age. Fasting decreased spleen weight, but bursa and yolk sac weight were not affected. Data showed that female and male chicks react in a similar way to post-hatching fasting, which affects body weight, liver and spleen weight, and HCT and PP values. Moreover, 72 hours of fasting affected more intensely HCT and MCV values.

  19. Power Doppler Ultrasound Evaluation of Peripheral Joint, Entheses, Tendon, and Bursa Abnormalities in Psoriatic Patients: A Clinical Study.

    Science.gov (United States)

    Tang, Yuanjiao; Yang, Yujia; Xiang, Xi; Wang, Liyun; Zhang, Lingyan; Qiu, Li

    2018-04-15

    To evaluate the prevalence rates of peripheral joint, enthesis, tendon, and bursa abnormalities by power Doppler (PD) ultrasonic examination in patients with psoriatic arthritis (PsA), psoriatic patients without clinical signs of arthritis (non-PsA psoriasis group), and healthy individuals, to detect subclinical PsA. A total of 253 healthy volunteers, 242 non-PsA psoriatic patients, and 86 patients with PsA were assessed by 2-dimensional and power Doppler (PD) ultrasound. Peripheral joint, enthesis, tendon, and bursa abnormalities were observed, characterizing abnormal PD. The affected patients and sites with abnormalities in various ages were compared among groups; PD signal grades for the abnormalities were also compared. In the PsA group, significantly higher percentages of sites showing joint effusion/synovitis, enthesitis, and tenosynovitis in all age groups, and markedly higher rates of sites with bursitis were found in young and middle age groups, compared with the non-PsA and control groups (all p the non-PsA group showed significantly higher rates of joint effusion/synovitis and enthesitis sites, and elevated PD signal grades of synovitis, enthesitis, and tenosynovitis in comparison with the control group, both in young and middle age groups (all p tenosynovitis.

  20. IDENTIFIKASI MANAJEMEN ASET DAN KINERJA KEUANGAN TERHADAP NILAI PASAR PADA PERUSAHAAN PROPERTI YANG TERDAFTAR DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Santy Mayda Batubara

    2017-06-01

    Full Text Available Tujuan penelitian ini adalah untuk menganalisis seberapa besar pengaruh manajemen aset dan kinerja keuangan berpengaruh terhadap nilai pasar pada perusahaan properti yang terdaftar di Bursa Efek Indonesia. Rancangan penelitian ini menggunakan data sekunder, dengan teknik purposive sampling, yaitu perusahaan sektor properti, dengan sub sektor properti dan real estate dan konstruksi bangunan, yang terdaftar di Bursa Efek Indonesia, sebanyak 72 pengamatan. Operasional variabel penelitian ini adalah Manajemen Aset diukur berdasarkan Fixed Asset Turnover (FAT dan Inventory Turnover (IT; dan Kinerja Keuangan diukur berdasarkan Return On Asset (ROA dan Return on Equity (ROE terhadap Nilai Pasar yang diukur berdasarkan Harga Saham Penutupan (HSP. Analisis penelitian ini menggunakan uji asumsi klasik dan uji hipotesis. Hasil penelitian ini yaitu (1 Manajemen Aset dan Kinerja Keuangan berdasarkan uji Simultan menyatakan bahwa secara bersama-sama atau serempak berpengaruh positif dan signifikan terdapat Nilai Pasar, (2 Namun berdasarkan uji parsial menyatakan bahwa yang berpengaruh positif dan signifikan adalah IT, sementara FAT, ROA dan ROE tidak berpengaruh positif dan signifikan, (3 Berdasarkan koefisien Determinasi menyatakan bahwa Manajemen Keuangan dan Kinerja Keuangan memiliki hubungan yang cukup erat terhadap Nilai Pasar dan memiliki peningkatan sebesar 11,4%.

  1. Teori Pecking Order dan Trade-Off dalam Analisis Struktur Modal di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    D Agus Harjito

    2014-06-01

    Full Text Available AbstractThis study aims to test the pecking order theory and trade-off theory of capital structure in the analysis of the Indonesia Stock Exchange. Pecking order theory is represented by the variable profitability and growth, while the variables volatility of earnings, tangibility of assets and the size represents a trade-off theory. The company's goal is prosperity of shareholder value. To achieve these objectives the company needs funds from internal sources and external sources. Internal sources in the form of retained earnings, while the external sources of debt and shareholders' approval in the pecking order theory. This study uses the data of financial ratios of the firms during the period 2000-2010. To analyze the data, this study uses a multiple regression with the dependent variable is the debt ratio, while profitability, growth, volatility of earnings, tangibility of assets and size as independent variables. The results show that asset structure and company size has a positive and significant impact on capital structure, while profitability has a negative effect on debt ratios. But company's growth rate has not relationship with the debt ratio or capital structure. Simultaneously, the all independent variables affect capital structure significantly.Keywords: pecking order, trade-off, capital structure, debt rasioAbstrakPenelitian ini bertujuan untuk menguji teori pecking order dan teori trade-off dalam analisis struktur modal di Bursa Efek Indonesia. Teori pecking order diwakili oleh variabel profitability dan growth, sementara variabel-variabel volatility of earnings, tangibility of assets dan size mewakili teori trade-off. Tujuan perusahaan adalah memakmurkan nilai pemegang saham. Untuk mencapai tujuan tersebut perusahaan membutuhkan dana yang diperoleh dari sumber internal dan sumber eksternal. Sumber internal berupa laba ditahan, sedangkan sumber eksternal berupa hutang dan saham sebagaimana dijelaskan dalam teori pecking order

  2. Obturator externus bursa: prevalence of communication with the hip joint and associated intra-articular findings in 200 consecutive hip MR arthrograms

    International Nuclear Information System (INIS)

    Kassarjian, Ara; Llopis, Eva; Schwartz, Richard B.; Bencardino, Jenny T.

    2009-01-01

    The purpose of the study was to demonstrate the prevalence of communication between the hip joint and the obturator externus bursa on hip MR arthrography. Following institutional review board approval, 200 hip MR arthrograms in 196 subjects were independently reviewed by two musculoskeletal radiologists. Discrepancies were resolved by adjudication. The presence or absence of communication between the hip joint and the obturator externus bursa was recorded. Associated lesions involving the acetabular labrum and articular cartilage were recorded. The obturator externus bursa was shown to communicate with the hip joint in 11 of the 200 (5.5%) hip MR arthrograms. Of these, six were in men and five were in women. The age range was 15-63 years with a mean age of 34 years. All 11 patients had labral tears. Eight of the 11 had cartilage lesions. The obturator externus bursa can be seen to communicate with the hip joint in 5.5% of hip MR arthrograms. Associated labral and cartilage lesions are common. (orig.)

  3. Obturator externus bursa: prevalence of communication with the hip joint and associated intra-articular findings in 200 consecutive hip MR arthrograms

    Energy Technology Data Exchange (ETDEWEB)

    Kassarjian, Ara [Corades, S.L., Majadahonda-Madrid (Spain); Massachusetts General Hospital, Division of Musculoksleletal Radiology, Boston, MA (United States); Llopis, Eva [Hospital de la Ribera, Department of Radiology, Alzira (Valencia) (Spain); Schwartz, Richard B. [Longwood MRI Specialists, Brookline, MA (United States); Bencardino, Jenny T. [NYU Department of Radiology, New York, NY (United States)

    2009-11-15

    The purpose of the study was to demonstrate the prevalence of communication between the hip joint and the obturator externus bursa on hip MR arthrography. Following institutional review board approval, 200 hip MR arthrograms in 196 subjects were independently reviewed by two musculoskeletal radiologists. Discrepancies were resolved by adjudication. The presence or absence of communication between the hip joint and the obturator externus bursa was recorded. Associated lesions involving the acetabular labrum and articular cartilage were recorded. The obturator externus bursa was shown to communicate with the hip joint in 11 of the 200 (5.5%) hip MR arthrograms. Of these, six were in men and five were in women. The age range was 15-63 years with a mean age of 34 years. All 11 patients had labral tears. Eight of the 11 had cartilage lesions. The obturator externus bursa can be seen to communicate with the hip joint in 5.5% of hip MR arthrograms. Associated labral and cartilage lesions are common. (orig.)

  4. Effects of chemical treatments and environmental factors on seed dormancy and germination of shepherd's purse (Capsella bursa-pastoris (L. Medic.

    Directory of Open Access Journals (Sweden)

    Mohammad Rezvani

    2014-12-01

    Full Text Available Shepherd's purse (Capsella bursa-pastoris is a problematic weed in citrus orchards and crop fields in northern Iran. In a series of laboratory and greenhouse experiments, we evaluated the effects that treatment with gibberellic acid (GA3 and potassium nitrate (KNO3, as well as environmental factors, including temperature, the duration of pre-chilling (wet and dry, drought stress, salt stress, pH, and sowing depth, have on seed dormancy breaking and germination in C. bursa-pastoris. Treatment with GA3 strongly stimulated germination of C. bursa-pastoris in conditions of light/dark and continuous darkness. The germination rate was highest (40.08% for seeds treated with 400 ppm of GA3 in the light/dark condition. Treatment with KNO3 did not significantly influence seed germination. Longer wet pre-chilling promoted germination and was more successful in seed dormancy breaking than was dry pre-chilling. Seed germination occurred at 10-30ºC and within a range of pH of 3-11. Drought and salt stress both strongly inhibited germination. Seedling emergence decreased in proportion to sowing depth. The rates of C. bursa-pastoris germination and seedling emergence were highest for seeds on the soil surface.

  5. A Study on Evaluation of the Biology Projects Submitted to the TUBITAK Secondary Education Research Projects Contest from the Bursa Region

    Science.gov (United States)

    Zeren Özer, Dilek; Güngör, Sema Nur; Özkan, Muhlis

    2015-01-01

    This study evaluates, through the employment of scientific methods and techniques, a total of 107 Biology projects submitted by secondary education students to the Bursa Region Coordinatorship of TUBITAK (a region which encompasses the municipalities of Afyonkarahisar, Balikesir, Bilecik, Canakkale, Eskisehir, Kutahya, and Yalova). The projects…

  6. Analisis Pengaruh Ukuran Kantor Akuntan Publik, Audit Fee, Audittenure, Dan Karakteristik Komite Audit Terhadap Audit Quality Pada Perusahaan Manufaktur Yang Terdaftar Di Bursa Efek Indonesia

    OpenAIRE

    William, Richi

    2017-01-01

    130503129 Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh ukuran kantor akuntan publik, audit fee, audit tenure, dan karakteristik komite audit terhadap kualitas audit pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia. Indikator karakteristik komite audit yaitu gender dan usia komite audit. Populasi penelitian ini sebanyak 151 perusahaan manufaktur. Metode pengambilan sampel yang digunakan adalah purposive sampling, sehingga diperoleh 27 perusahaan s...

  7. Concurrent Fowlpox and Candidiasis Diseases in Backyard Chickens with Unusual Pox Lesions in the Bursa of Fabricius.

    Science.gov (United States)

    Ogasawara, Fusae; Yamamoto, Yu; Sato, Yasuo; Fukunari, Kazuhiro; Murata, Ken-Ichi; Yaegashi, Gakuji; Goto, Makiko; Murakami, Ryukoh

    2016-09-01

    Concurrent fowlpox and candidiasis diseases occurred in a backyard chicken flock. Four deceased chickens (one Nagoya breed and three white silkie chickens) were examined for diagnosis. At necropsy, white curd-like plaques were observed in the crop. Fungal elements that stained positive for Candida albicans with immunohistochemistry were distributed throughout the tongue, choanal mucosa, esophagus, and crop. Typical fowlpox lesions, composed of proliferating epithelial cells with ballooning degeneration and viral intracytoplasmic inclusions, were observed in the conjunctiva, nasal mucosa, and skin around the cloaca. Interestingly, hyperplastic interfollicular epithelium with rare virus inclusions was observed in the bursa of Fabricius (BF). Some bursal follicles were replaced by proliferating epithelial cells. These proliferating cells immunohistochemically stained positive for cytokeratin. PCR and subsequent genetic sequencing detected the C. albicans gene in the crop, and fowlpox virus genes in the BF. These results indicate that this outbreak was a rare presentation of fowlpox in spontaneously infected chickens, with unusual pox lesions in the BF.

  8. Food composition of Uludağ frog, Rana macrocnemis Boulenger, 1885 in Uludağ (Bursa, Turkey

    Directory of Open Access Journals (Sweden)

    Kerim Çiçek

    2011-06-01

    Full Text Available Feeding habit and food preferences of Uludağ frog, Rana macrocnemis were studied in 2006 and 2007 in Uludağ (Bursa, Turkey. Stomach contents of 165 (87 males, 58 females, 20 juveniles individuals were analyzed and a total of 2,129 prey items were determined. It was found that the species fed mainly on a variety of invertebrates and especially on insects (96.5%. The most frequently consumed prey items were Coleoptera (62.8%, Diptera (14.4%, and Hymenoptera (9.8%. There was no significant sex- and age-dependent difference in the feeding regime. It appears that the species is feeding less in the breeding period and more in the post-breeding period. It was also evident that there was an increase in the consumption of Coleoptera depending on the elevation.

  9. 30 Years Retrospective Review of Tuberculosis Cases in a Tuberculosis Dispensary in Bursa/Nilufer, Turkey (1985-2014

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    Kayıhan PALA

    2016-11-01

    Full Text Available Abstract Objective: The aim of this study was to evaluate tuberculosis control programmes of patients who applied to the Bursa Nilufer Tuberculosis Dispensary and by investigating the changes in the variables over 3 decades. Method: In this retrospective descriptive study, the records of all tuberculosis cases (1662 people treated in the last 30 years (1985-2014 at the Bursa Nilufer Tuberculosis Dispensary were examined. In the analysis, the chi-square test, the trend chi-square test and Fisher's exact test were used. Results: Males comprised 65.2% of the patients. The ages of the patients ranged from 1 to 87 years, and the mean age was 37.4 (95% CI:36.6-38.2. Among the cases, 86.7% were new and 74.1% were pulmonary tuberculosis. In the last decade, the proportion of women, the education level, the proportion of patients who had received a BCG vaccination and the proportion of active employees among women increased by a statistically significant amount, while the proportion of employees among men decreased. Clinical symptoms, such as weakness, anorexia, weight loss, and cough, decreased to a statistically significant degree. In the last decade, the mortality rate was 3.6%, a statistically significant increase compared with previous decades. Mortality was statistically significant higher among patients who were elderly, male, did not have a BCG scar or had a chronic disease. Conclusion: This study reveals the need for studies that determine the risk factors associated with tuberculosis mortality and examine the effectiveness of tuberculosis control programmes. Direct measures to address mortality risk factors can reduce the number of deaths from tuberculosis.

  10. Optimized sample preparation for two-dimensional gel electrophoresis of soluble proteins from chicken bursa of Fabricius

    Directory of Open Access Journals (Sweden)

    Zheng Xiaojuan

    2009-10-01

    Full Text Available Abstract Background Two-dimensional gel electrophoresis (2-DE is a powerful method to study protein expression and function in living organisms and diseases. This technique, however, has not been applied to avian bursa of Fabricius (BF, a central immune organ. Here, optimized 2-DE sample preparation methodologies were constructed for the chicken BF tissue. Using the optimized protocol, we performed further 2-DE analysis on a soluble protein extract from the BF of chickens infected with virulent avibirnavirus. To demonstrate the quality of the extracted proteins, several differentially expressed protein spots selected were cut from 2-DE gels and identified by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS. Results An extraction buffer containing 7 M urea, 2 M thiourea, 2% (w/v 3-[(3-cholamidopropyl-dimethylammonio]-1-propanesulfonate (CHAPS, 50 mM dithiothreitol (DTT, 0.2% Bio-Lyte 3/10, 1 mM phenylmethylsulfonyl fluoride (PMSF, 20 U/ml Deoxyribonuclease I (DNase I, and 0.25 mg/ml Ribonuclease A (RNase A, combined with sonication and vortex, yielded the best 2-DE data. Relative to non-frozen immobilized pH gradient (IPG strips, frozen IPG strips did not result in significant changes in the 2-DE patterns after isoelectric focusing (IEF. When the optimized protocol was used to analyze the spleen and thymus, as well as avibirnavirus-infected bursa, high quality 2-DE protein expression profiles were obtained. 2-DE maps of BF of chickens infected with virulent avibirnavirus were visibly different and many differentially expressed proteins were found. Conclusion These results showed that method C, in concert extraction buffer IV, was the most favorable for preparing samples for IEF and subsequent protein separation and yielded the best quality 2-DE patterns. The optimized protocol is a useful sample preparation method for comparative proteomics analysis of chicken BF tissues.

  11. Ecotypic and allozyme variation of Capsella bursa-pastoris and C. rubella (Brassicaceae along latitude and altitude gradients on the Iberian Peninsula

    Directory of Open Access Journals (Sweden)

    Hoffrogge, Raimund

    1999-12-01

    Full Text Available Life-history traits (onset of flowering, leaf number, rosette diameter, plant height, branching number, fruit dimensions, seed number of Capsella species from the Iberian Península associated with colotúzing ability were compared in a random block field experiment. Data were evaluated by a principal component analysis. Allozymes (AAT, LAP, GDH and leaf types were recorded. C. bursa-pastoris plants originating from low and high elevations of the summer dry Mediterranean climatic zone (Sierra Nevada were early flowering, whereas those originating from the Pyrenees with an alpine climate were late. In C. bursa-pastoris the "rhomboidea" leaf type was very frequent, whereas in C. rubella it was the "heteris" leaf type. There was a change of leaf type frequencies along geographical clines which is explained by adaptive components of the leaf shape. The allozymes displayed a geographical distribuüon pattem and in C. bursa-pastoris a certain multilocus genotype appeared to be a molecular marker for an early flowering ecotype(inicio de la floración, número de hojas, diámetro de la roseta, altura de la planta, número de ramas, dimensiones del fruto y número de semillas de plantas de Capsella procedentes de la Península Ibérica mediante un experimento de bloques aleatorios en el campo. Los datos se evaluaron con un análisis de componentes principales. También se registraron el tipo de hojas y el perfil aloenzimático de las plantas. Las plantas de Capsella bursa-pastoris procedentes de altitudes altas y bajas de la zona climática Mediterránea de verano seco (Sierra Nevada mostraron ser de floración temprana, mientras que las plantas de los Pirineos, con un clima alpino, presentaron una floración tardía. En C. bursa-pastoris el tipo de hoja "rhomboidea" resultó ser el más frecuente, en tanto que en C. rubella lo fue el tipo "heteris". Se observó un cambio en las frecuencias de los tipos de hojas a lo largo de una clina geográfica, lo

  12. PENGARUH CAR, NPL, DAN LDR TERHADAP ROA (STUDI PADA BANK UMUM YANG LISTING DI BURSA EFEK INDONESIA TAHUN 2007-2011)

    OpenAIRE

    SANTOSA, ANGGITA PUJI

    2012-01-01

    2012 Pengaruh CAR, NPL, Dan LDR Terhadap ROA(Studi Pada Bank Umum Yang Listing Di Bursa Efek Indonesia Tahun 2007-2011) The Effect of Capital Adequacy Ratio, Non Performing Loan, and Loan to Deposit Ratio to Return On Assets( A study in Commercial Banking that Listed on Indonesian Stock Exchange Period 2007-2011) Anggita Puji Santosa Cepi Pahlevi Gamalca Penelitian ini bertujuan untuk menganalisis pengaruh CAR, NPL dan LDR terhadap ROA.Data yang digunakan dalam penelitia...

  13. PENGARUH KOMITE AUDIT, RETURN ON ASSETS DAN DEBT TO TOTAL ASSETS TERHADAP AUDIT REPORT LAG PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA

    OpenAIRE

    Ariani,

    2014-01-01

    Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh independensi komite audit terhadap audit report lag, mengetahui pengaruh return on assets terhadap audit report lag dan mengetahui pengaruh debt to total assets terhadap audit report lag. Penelitian ini dilakukan pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia tahun 2010 – 2012. Hasil penelitian menunjukkan bahwa independensi komite audit berpengaruh negatif terhadap audit report lag, return on assets berpen...

  14. Detection of immunoglobulins containing plasma cells in the thymus, bursa of Fabricius and spleen of vaccinated broiler chickens with Newcastle disease virus vaccine

    Directory of Open Access Journals (Sweden)

    Md. Abdul Masum

    2014-12-01

    Full Text Available Mobilization of immunoglobulins (Igs-containing plasma cells (IgA, IgG and IgM in the spleen, bursa of Fabricius and thymus was investigated in broiler chickens that were vaccinated with Newcastle disease virus (NDV vaccine. In the thymus, the Igs-containing plasma cells were distributed in the cortex and medulla. Their frequency and distribution were higher at D14 and at D28. The number of IgG- and IgM-positive cells was greater than IgA-positive cells in thymus. In the bursa of Fabricius, Igs-containing plasma cells were distributed beneath the capsules; within and around the bursal follicles. Their frequency of occurrence significantly peaked at D14 and at D28 in comparison to day-old chickens, and IgG-positive cells were significantly greater than the IgA- and IgM-positive cells in the bursa of vaccinated chickens. In the spleen, Igs-containing plasma cells were distributed in the white pulp, around the trabeculae, and in the periarterial lymphatic sheath. In this secondary lymphatic tissue, IgG- and IgM-positive cell numbers significantly greater than IgA-positive cells. In conclusion, mobilization of more Igs-positive cells in lymphoid tissues of broiler chickens is due to the effect of NDV vaccine as well as the advancement of age.

  15. The Impact of Structural Transformation in the Retail Sector on the Producer and Consumer Market in Bursa

    Directory of Open Access Journals (Sweden)

    Ebru SEÇKİN

    2015-02-01

    Full Text Available There has been transformation of the food retail sector in the last 20 years, accompanied by multi-nationalization of the supermarket sector itself. Modern supply chains comprise the production and trade of high-value produce, usually destined for export to high-income markets or for supermarket retail. Two striking changes in the retail food sector have been the movement of supermarket chains towards specialized wholesalers in the organization of their procurement systems, and the emergence of strict quality and safety standards. Debates on the supermarket revolution and its impact on small farmers continue in the literature. Some writers suggest that small farmers are excluded from modern supply chains because they cannot meet supermarkets’ requirements. However, some writers imply that small farmers are not under threat. In this context, this paper aimed to examine the relationship between buyer and supplier, and reveal the structural and behavioural stresses of the modern supply chain in the context of the pear supply chain in Bursa (Gürsu. There are two research questions: 1 Are small farmers excluded from modern supply chains? 2 Are there differences between farmers in modern and traditional supply chains? The study concluded that there is a dual structure at work, in which traditional and modern supply chains intertwine and operate side by side. The study also found that small farmers are not excluded from the modern supply chain, and that there are no differences between farmers in modern and traditional supply chains.

  16. Pengembangan Sistem Informasi Berbasis Web untuk Peningkatan Kinerja Unit Bursa Kerja Khusus SMK Negeri 1 Tanjung Raya

    Directory of Open Access Journals (Sweden)

    Amalina Amalina

    2018-01-01

    Full Text Available SMK Negeri 1 Tanjung Raya merupakan salah satu satuan pendidikan yang berada di Kabupaten Agam. SMK Negeri 1 Tanjung Raya memiliki sebuah unit Bursa Kerja Khusus (BKK yang bertugas memberikan informasi kepada siswa praktik kerja industri (prakerin mengenai tempat magang yang dapat mereka pilih. Unit BKK juga berfungsi untuk memberikan informasi kepada alumni terkait lowongan pekerjaan. Informasi yang diberikan kepada siswa dan alumni dilakukan menggunakan papan pengumuman di sekolah. Cara tersebut dirasa kurang efektif karena informasi tidak cepat sampai kepada siswa dan lulusan yang membutuhkan. Siswa dan alumni harus sering datang ke sekolah agar mendapat informasi yang mutakhir sedangkan sebagian siswa dan alumni tinggal jauh dari sekolah dalam kondisi transportasi yang kurang baik. Untuk mengatasi permasalahan tersebut, dikembangkan sistem informasi berbasis web untuk pengelolaan data di unit BKK. Sistem informasi dirancang menggunakan bahasa pemrograman PHP dan basis data MySQL. Sistem melibatkan lima user yakni admin, operator BKK, operator prakerin, siswa dan alumni. Kelima level user yang terdaftar memiliki akun private untuk dapat masuk ke dalam sistem yakni username dan password dengan enkripsi MD5. Halaman utama sistem menampilkan informasi berita, lowongan kerja, dan rekapitulasi data alumni. Sistem diharapkan dapat meningkatkan kinerja unit BKK dalam memberikan informasi tentang lowongan kerja kepada siswa prakerin dan alumni.

  17. REAKSI PASAR MODAL TERHADAP PELAPORAN SELISIH KURS PERSPEKTIF FOREIGN CURRENCY FORWARD EXCHANGE-IFRS (STUDI EMPIRIS DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    R. Anastasia Endang Susilawati

    2011-02-01

    Full Text Available Penelitian ini bertujuan memberikan bukti empiris mengenai pelaporan selisih kurs terhadap reaksi pasar modal dengan menggunakan return saham sebagai proxy. Sampel penelitian diperoleh 31 perusahaan dari Bursa Efek Indonesia pada periode pengamatan antara tahun 2007-2010 menggunakan metode purposive sampling. Temuan penelitian ini mendukung hipotesis satu dan hipotesis dua bahwa terdapat hubungan signifikan antara pelaporan rugi selisih kurs yang diakui sebagai pendapatan/biaya dengan return saham. Return saham tidak berkorelasi secara signifikan dengan perubahan pendapatan bersih atau revenue. Return saham berkorelasi negatif dan signifikan dengan perubahan cash flow dibagi dengan total assets. Return saham tidak berkorelasi secara signifikan dengan pelaporan rugi selisih kurs. Dari uji beda, investor merespon tidak berbeda dengan melihat return saham terhadap dua metode pelaporan akuntansi atas laba/rugi selisih kurs yaitu yang mengakui sebagai pendapatan/biaya dan yang mengkapitalisasi laba/rugi selisih kurs tersebut. Penelitian selanjutnya diharapkan memasukkan perusahaan yang mengkapitalisasi laba/rugi selisih kurs sebagian pada seluruh jenis industri dan membandingkan ketiga metode pelaporan selisih kurs 

  18. Estimation of soil erosion risk within an important agricultural sub-watershed in Bursa, Turkey, in relation to rapid urbanization.

    Science.gov (United States)

    Ozsoy, Gokhan; Aksoy, Ertugrul

    2015-07-01

    This paper integrates the Revised Universal Soil Loss Equation (RUSLE) with a GIS model to investigate the spatial distribution of annual soil loss and identify areas of soil erosion risk in the Uluabat sub-watershed, an important agricultural site in Bursa Province, Turkey. The total soil loss from water erosion was 473,274 Mg year(-1). Accordingly, 60.3% of the surveyed area was classified into a very low erosion risk class while 25.7% was found to be in high and severe erosion risk classes. Soil loss had a close relationship with land use and topography. The most severe erosion risk typically occurs on ridges and steep slopes where agriculture, degraded forest, and shrubs are the main land uses and cover types. Another goal of this study was to use GIS to reveal the multi-year urbanization status caused by rapid urbanization that constitutes another soil erosion risk in this area. Urbanization has increased by 57.7% and the most areal change was determined in class I lands at a rate of 80% over 25 years. Urbanization was identified as one of the causes of excessive soil loss in the study area.

  19. KOINTEGRASI BURSA-BURSA SAHAM DI ASIA

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    Riko Hendrawan

    2017-03-01

    Full Text Available One important indicator of capital market development could be seen from the value of the composite stockprice index. Composite stock price index reflected the performance of all shares registered in particular country.The objective of this research was to know whether there was co integration or long-term equilibriumamong Indonesia, Malaysia, Singapore, Thailand, Philippines, Hongkong, Japan, South Korea and China,either in groups or in pairs using the method of co-integration during January 2000 - January 2010. Theresults of this research using Johansen Co-Integration test indicated that there was long-term equilibriumamong Indonesia, Malaysia, Singapore, Thailand, Philippines, Hongkong, Japan, South Korea and China inthe period of January 2000 - January 2010, in groups and in pairs. The results showed that the South Koreastock market was the most influential to the Indonesian stock markets, and China’s stock market was the mostdominant stock market among these countries during January 2000 - January 2010.

  20. Ocorrência de Ornithonyssus bursa (Berlese, 1888 (Acari: Macronyssidae em filhotes de Megascops choliba (corujinha-do-mato e Pitangus sulphuratus (bem-te-vi, no Rio Grande do Sul, Brasil Ocurrence of Ornithonyssus bursa (Berlese, 1888 (Acari: Macronyssidae on Megascops choliba (tropical screech-owl and Pitangus sulphuratus (great kiskadee nestlings in the Rio Grande do Sul State, Brazil

    Directory of Open Access Journals (Sweden)

    Carolina S. Mascarenhas

    2009-12-01

    Full Text Available O Núcleo de Reabilitação da Fauna Silvestre e Centro de Triagem de Animais Silvestres da Universidade Federal de Pelotas - RS atendeu dois filhotes de Megascops choliba (corujinha-do-mato (Strigiformes - Strigidae e dois de Pitangus sulphuratus (bem-te-vi (Passeriformes - Tyrannidae intensamente parasitados por ácaros, em maio de 2005 e dezembro de 2006, respectivamente. Os filhotes e o ninho de P. sulphuratus foram recolhidos na zona urbana da cidade de Pelotas - RS após forte temporal. Os ácaros foram removidos, colocados em álcool 70% e levados ao laboratório de parasitologia para identificação. Os espécimes foram clarificados em lactofenol, montados em meio de Hoyer e identificados como Ornithonyssus bursa (Acari - Macronyssidae. Registra-se Megascops choliba e Pitangus sulphuratus como hospedeiros de Ornithonyssus bursa, no Rio Grande do Sul, Brasil.The Center for Rehabilitation of Wildlife and Center for Selection of Wild Animal of the Federal University of Pelotas has attended two nestlings of Megascops choliba (tropical screech-owl (Strigiformes - Strigidae and two of Pitangus sulphuratus (great kiskadee (Passeriformes - Tyrannidae heavily parasitized by mites, in May 2005 and December 2006, respectively. The nestlings and the nest of P. sulphuratus were collected in the Pelotas urban area after severe storms. The mites were removed, clarified in lactofenol, permanently mounted in Hoyer's medium and identified as Ornithonyssus bursa (Acari - Macronyssidae. Megascops choliba and Pitangus sulphuratus are reported as host of Ornithonyssus bursa in Rio Grande do Sul State, Brazil.

  1. Development of the auto gas and LPG-powered vehicle sector in Turkey: A statistical case study of the sector for Bursa

    International Nuclear Information System (INIS)

    Karamangil, M. Ihsan

    2007-01-01

    In this paper, the development of LPG-powered vehicle sector in Turkey and the policies applied by the Turkish Government as well as the total fleet of LPG-powered vehicles in Bursa province, which is assumed as typical district to represent whole Turkey, are analyzed. We also tried to point out economical losses and applicational problems caused by wrong energy and environmental policies in Turkey. We aimed to focus a guiding light on the newly developing auto gas markets in different countries through the problems resulting from the fast growth of the sector and the experiences in Turkish application

  2. Lipoma arborescens: rare case of rotator cuff tear associated with the presence of lipoma arborescens in the subacromial-subdeltoid and glenohumeral bursa

    OpenAIRE

    Benegas, Eduardo; Ferreiro Neto, Arnaldo Amado; Teodoro, Daniel Sabatini; Silva, Marcos Vinícius Muriano da; Oliveira, Augusto Medaglia de; Filippi, Renée Zon; Prada, Flávia de Santis

    2012-01-01

    Lipoma arborescens é uma condição rara de moléstia intra-articular, usualmente monoarticular, caracterizada por extensa proliferação dos vilos sinoviais e hiperplasia da gordura subsinovial. O tecido sinovial é progressivamente substituído por células maduras de gordura na membrana sinovial. O presente trabalho é o relato de caso de uma condição rara de lipoma arborescens tanto intra-articular (glenoumeral) como da bursa subacromial-subdeltoide além de ruptura do tendão do supraespinhoso. As ...

  3. The Gene Ontology Differs in Bursa of Fabricius Between Two Breeds of Ducks Post Hatching by Enriching the Differentially Expressed Genes

    Directory of Open Access Journals (Sweden)

    H Liu

    Full Text Available ABSTRACT The bursa of Fabricius (BF is the central humoral immune organ unique to birds. The present study investigated the possible difference on a molecular level between two duck breeds. The digital gene expression profiling (DGE technology was used to enrich the differentially expressed genes (DEGs in BF between the Jianchang and Nonghua-P strains of ducks. DGE data identified 195 DEGs in the bursa. Gene Ontology (GO analysis suggested that DEGs were mainly enriched in the metabolic pathways and ribosome components. Pathways analysis identified the spliceosome, RNA transport, RNA degradation process, Jak-STAT signaling pathway, TNF signaling pathway and B cell receptor signaling pathway. The results indicated that the main difference in the BF between the two duck strains was in the capabilities of protein formation and B cell development. These data have revealed the main divergence in the BF on a molecular level between genetically different duck breeds and may help to perform molecular breeding programs in poultry in the future.

  4. Expression analysis and functional characterization of a novel cold-responsive gene CbCOR15a from Capsella bursa-pastoris.

    Science.gov (United States)

    Zhou, Mingqi; Wu, Lihua; Liang, Jing; Shen, Chen; Lin, Juan

    2012-05-01

    The cold-responsive (COR) genes involved in C-repeat binding factor signaling pathway function essentially in cold acclimation of higher plants. A novel COR gene CbCOR15a from shepherd's purse (Capsella bursa-pastoris) was predicted to be a homolog of COR15 in Arabidopsis. The analysis of tissue specific expression pattern as well as characterization of the CbCOR15a promoter revealed that the expression of CbCOR15a was induced by coldness not only in leaves and stem but also in roots. Sequence analysis showed that a 909 bp promoter region of CbCOR15a contained two CRT/DRE elements, two ABRE elements, one auxin-responsive TGA-element and one MeJA-responsive CGTCA-motif. In young seedlings the expression of CbCOR15a could be apparently increased by SA, ABA, MeJA and IAA, and transiently increased by GA(3) accompanied by obvious feedback suppression. According to the altered physiological index values in tobacco under cold treatments, the overexpression of CbCOR15a significantly increased the cold tolerance of transgenic tobacco plants. It can be suggested that CbCOR15a was involved in cold response of Capsella bursa-pastoris associated with SA, ABA, MeJA, IAA and GA(3) regulation and confers enhanced cold acclimation in transgenic plants.

  5. PENGARUH PROFITABILITY DAN INVESTMENT OPPORTUNITY SET TERHADAP KEBIJAKAN DIVIDEN TUNAI DENGAN LIKUIDITAS SEBAGAI VARIABEL PENGUAT (Studi pada Perusahaan yang Terdaftar di Bursa Efek Jakarta

    Directory of Open Access Journals (Sweden)

    Michell Suharli

    2007-01-01

    Full Text Available The objective of this research is to study influence of profitability and investment opportunity as independent variable, and liquidity as moderating variable toward cash dividend. It is interesting to analyze factors that influence dividend policy because to many considerations. Sometimes those considerations cause conflict between many parties. Research object is companies that delisting in Bursa Efek Jakarta that paid dividend. Research sample using purposive sampling of companies for period ended 2002 and 2003. This research concludes that both of two independent variables have significant influence toward dividend amount policy, and liquidity moderate the influence. Abstract in Bahasa Indonesia : Penelitian ini bermaksud menguji pengaruh profitabilitas dan kesempatan investasi terhadap kebijakan jumlah dividen kas perusahaan publik di Jakarta dengan menggunakan likuiditas sebagai variabel penguat (variabel moderator. Profitabilitas diukur dengan return on investment (ROI, kesempatan investasi diproksikan oleh fixed assets, dan liquiditas sebagai variabel moderat diproksikan oleh current ratio di Bursa Efek Jakarta.. Populasi penelitian ini adalah seluruh perusahaan di Indonesia yang listing di BEJ dan membagikan dividen pada tahun 2002-2003. Hasil penelitian ini adalah kebijakan jumlah pembagian dividen perusahaan dipengaruhi oleh profitabilitas dan diperkuat oleh likuiditas perusahaan. Kata kunci: dividen, profitabilitas, return on investment

  6. PENGARUH ROTASI AUDIT, WORKLOAD, DAN SPESIALISASI TERHADAP KUALITAS AUDIT PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA PADA TAHUN 2009-2013

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    Febrian Adhi Pratama Ishak

    2016-01-01

    Full Text Available This purpose research is for to understand the effect of structure corporate governance to performance companies listing on the Indonesia Stock Exchange in 2012-2014. The sample used in this study were manufacturing  sector companies for the year 2012-2014. The method used in data collection is the secondary method of data collection, financial report its being obtained from website IDX. The method of analysis of this study used multiple regression .The result from research is indicate that structure corporate governance is significant effect on performance of manufacturing companies. Tujuan penelitian ini adalah untuk memahami efek dari struktur tata kelola perusahaan pada perusahaan yang listing di Bursa Efek Indonesia pada 2012-2014. Sampel yang digunakan dalam penelitian ini adalah perusahaan manufaktur sektor untuk tahun 2012-2014. Metode yang digunakan dalam pengumpulan data adalah metode pengumpulan data sekunder berupa laporan keuangan yang diperoleh dari website Bursa Efek Indonesia. Metode analisis penelitian ini menggunakan regresi berganda. Hasil dari penelitian adalah menunjukkan struktur yang tata kelola perusahaan yang berpengaruh signifikan terhadap kinerja perusahaan manufaktur.

  7. Antibacterial activity of Tribulus terrestris and its synergistic effect with Capsella bursa-pastoris and Glycyrrhiza glabra against oral pathogens: an in-vitro study.

    Science.gov (United States)

    Soleimanpour, Saman; Sedighinia, Fereshteh Sadat; Safipour Afshar, Akbar; Zarif, Reza; Ghazvini, Kiarash

    2015-01-01

    In this study, antimicrobial activities of an ethanol extract of Tribulus terrestris aloneand in combination with Capsella bursa-pastoris and Glycyrrhiza glabra were examined in vitro against six pathogens namely Streptococcus mutans, Streptococcus sanguis, Actinomyces viscosus, Enterococcus faecalis Staphylococcus aureus, and Escherichia coli. Antibacterial activities of the extracts were examined using disc and well diffusion methods and the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of ethanol extracts were determined against these microorganisms using agar and broth dilution methods. Chlorhexidine was used as positive control. Tribulus terrestris extract exhibited good antibacterial activity against all bacteria. Antibacterial activity of mixed extract was evaluated and exhibited that mixed extract was more effective against all bacteria than any of the cases alone which indicates the synergistic effect between these three extracts (p˂0.05). No strain showed resistance against these extracts. In agar dilution, Tribulus terrestris exhibited MIC values ranging from 35.0 to 20.0 mg/ml and mixed extract showed MIC values ranging from 12.5 to 5.0 mg/ml. The results of broth dilution method were consistent with the findings of the agar dilution method. This in-vitro study was a preliminary evaluation of antibacterial activity of the plants. It provided scientific evidence to support uses of T. terrestris and its mixture with C. bursa-pastoris and G. glabra for the treatment of oral infections. In-vivo studies are also required to better evaluate the effect of these extracts.

  8. ANALISIS VARIABEL YANG MEMPENGARUHI PRICE EARNING RATIO DALAM PENILAIAN HARGA SAHAM DI BURSA EFEK JAKARTA (TAHUN 1998 – 2001

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    Marli - -

    2012-05-01

    Full Text Available ABSTRAK Penilaian harga saham berdasarkan analisa fundamental diklasifikasikan pada pendekatan dividend discount model dan P/E ratio. Permasalahan yang penting dalam penelitian ini menyangkut tentang aplikasi penilaian harga saham berdasarkan pendekatan PER dengan menggunakan variabel bebas yang dianggap relevan mempengaruhi harga saham. Selain itu, juga dapat digunakan untuk menjelaskan kondisi harga saham, variabel mana yang dominan dan bagaimana perubahan harga sahamnya dengan acuan pada pendekatan P/E ratio. Variabel yang dipertimbangkan oleh investor dalam melakukan investasi di pasar modal diantaranya dividend payout ratio, standard deviation of EPS, return on equity dan debt to equity ratio sedangkan earning growth tetap dipertimbangkan tetapi dengan tingkat signifikansi yang lebih rendah. Return on equity merupakan variabel penelitian yang paling dominan mempengaruhi harga saham. Harga saham di Bursa efek Jakarta belum menunjukkan harga yang wajar dan berdasarkan analisa teknikal dengan menggunakan indikator moving average dan trend, kecenderungan perubahan harga sahamnya tidak selalu menuju nilai intrinsiknya. Kata kunci: P/E ratio, return on equity, debt to equity ratio ABSTRACT The assessment of stock price based on fundamental analyse is grouped on model discount dividend approach and P/E ratio. The important problems in this research include assessment stock price application based on PER approach using independent variable which have relevant influence at stock price. It also used to explain stock price condition, dominant variable, and how is the changing of stock price with based on P/E ratio approach. Variable considered by investor on conducting investment in stock exchange market are: dividend payout ratio, standard deviation of EPS, return on equity, and debt to equity ratio while earning growth also considered but at lower significance level. Return on equity is dominant influence research variable on stock price. Stock

  9. PENGARUH RISIKO KREDIT DAN EFISIENSI OPERASIONAL TERHADAP KINERJA BANK (Studi Empirik pada Bank yang Terdaftar di Bursa Efek Indonesia

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    Bambang Sudiyatno

    2015-04-01

    Full Text Available Penelitian ini menguji pengaruh risiko kredit dan efisiensi operasional, terhadap kinerja bank yang terdaftar di Bursa Efek Indonesia periode 2007-2010. Risiko kredit diproksi dengan Loan to Deposit Ratio (LDR, dan efisiensi operasional diproksi dengan Capital Adecuacy Ratio (CAR dan Biaya Operasi (BOPO, sedangkan kinerja bank diproksi dengan Return on Asset (ROA. Tujuan penelitian ini adalah untuk mengidentifikasi faktor mana, dari risiko kredit dan efisiensi operasi yang pengaruhnya lebih besar terhadap kinerja bank. Sampel yang diambil dalam penelitian ini sebanyak 96 perusahaan perbankan selama tahun 20072010, yang dipilih dengan metode purposive sampling. Untuk mendapatkan informasi yang dibutuhkan dilakukan proses pengumpulan data melalui dokumentasi. Tehnik analisis data dilakukan dengan analisis regresi linier berganda, untuk mengetahui adanya pengaruh CAR, BOPO, dan LDR terhadap ROA. Hasil analisis menunjukan bahwa rasio keuangan, yang terdiri dari rasio CAR dan LDR berpengaruh positif tetapi tidak signifikan terhadap ROA. Sedangkan BOPO berpengaruh negative dan signifikan terhadap ROA. Kemampuan prediksi dari tiga variabel tersebut terhadap ROA sebesar 18,8% sebagaimana yang telah ditunjukan oleh adjusted R square sebesar 0,188. This study examined the effect of credit risk and operational efficiency on the performance of banks listed on the Indonesia Stock Exchange between 2007-2010. Credit risk proxied by Loan to Deposit Ratio (LDR, and operational efficiency proxied by Capital Adecuacy Ratio (CAR and Operating Costs (BOPO, while the bank's performance proxied by Return on Assets (ROA. The purpose of this study was to identify which factors, from credit risk and operating efficiencies greatest influence on the performance of banks. Samples taken in this study were 96 banking companies during the years 2007 to 2010, were selected by purposive sampling method. To get the required information, performed the data collection process

  10. Potential Cost-Effectiveness of RSV Vaccination of Infants and Pregnant Women in Turkey: An Illustration Based on Bursa Data.

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    Koen B Pouwels

    Full Text Available Worldwide, respiratory syncytial virus (RSV is considered to be the most important viral cause of respiratory morbidity and mortality among infants and young children. Although no active vaccine is available on the market yet, there are several active vaccine development programs in various stages. To assess whether one of these vaccines might be a future asset for national immunization programs, modeling the costs and benefits of various vaccination strategies is needed.To evaluate the potential cost-effectiveness of RSV vaccination of infants and/or pregnant women in Turkey.A multi-cohort static Markov model with cycles of one month was used to compare the cost-effectiveness of vaccinated cohorts versus non-vaccinated cohorts. The 2014 Turkish birth cohort was divided by twelve to construct twelve monthly birth cohorts of equal size (111,459 new-borns. Model input was based on clinical data from a multicenter prospective study from Bursa, Turkey, combined with figures from the (international literature and publicly available data from the Turkish Statistical Institute (TÜÏK. Incremental cost-effectiveness ratios (ICERs were expressed in Turkish Lira (TL per quality-adjusted life year (QALY gained.Vaccinating infants at 2 and 4 months of age would prevent 145,802 GP visits, 8,201 hospitalizations and 48 deaths during the first year of life, corresponding to a total gain of 1650 QALYs. The discounted ICER was estimated at 51,969 TL (26,220 US $ in 2013 per QALY gained. Vaccinating both pregnant women and infants would prevent more cases, but was less attractive from a pure economic point of view with a discounted ICER of 61,653 TL (31,106 US $ in 2013 per QALY. Vaccinating only during pregnancy would result in fewer cases prevented than infant vaccination and a less favorable ICER.RSV vaccination of infants and/or pregnant women has the potential to be cost-effective in Turkey. Although using relatively conservative assumptions, all evaluated

  11. Popüler Roman ve Gençler Üzerindeki Etkileri- Bursa Örneği- Popular Novel and Its Effects on the Young-Bursa Example-

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    Fatih ACER

    2013-07-01

    study many topics such as why popular novel has such popularity among the young, what it adds to the young's lives, the family and the environment factors in the preference of this novel, whether it will become a transition step to the aesthetic novel, the meaning of popular novel in the eye of the young, the influence of the school types on the novels selected, have been presented through the questionnaires and conclusions from their results. The research area was restricted to Bursa province. The questionnaires were conducted in 2011-2012 Education Year in a sample school from each type of the secondary education institutions in Bursa. In these schools, the questionnaires were applied to 421 students who were reading popular novel and chosen by literature teachers. In this study cross-graphics were obtained by using SPSS programme 15. In conclusion and suggestions part of this study, the results were presented as conclusions deduced from the comparisons made in the tables. Bu makalenin amacı öncelikle gençlerin popüler romanları tercih sebeplerini tespit etmektir. Tercih edilen popüler romanların gençlerin hayatına nasıl bir anlam kattığı ve bu türün estetik romanlara oranla çok okunmasının altında yatan sebepler ortaya konmuştur. Giriş bölümünde popüler romanın genel özellikleri verilmiştir. Bu bölümde popüler romanın çok da kayda değer bir tür olmadığı algısının yaygın olduğu belirtilmiştir. Yazarı açısından estetik gaye güdülmeksizin kaleme alınan; yayılıp yazılmasında başta ticari kaygı olmak üzere, sanat dışı sebepler bulunan; okurun fikrinden çok duygu ve heyecanlarını harekete geçirmeyi hedefleyen; çok sayıda okura ulaşan; kolay anlaşılıp rahat çözümlenen; okurda belli bir seviye aramayan basma kalıp bir yapı arz eden; bir çoğu filme alınarak okur dışında sinema ve televizyonda da çok sayıda izleyiciye ulaşmış nitelikteki romanlardır. Bunun yanında yazarı taraf

  12. ANALISIS VARIABEL YANG MEMPENGARUHI EARNINGS PER SHARE PADA INDUSTRI FOOD AND BAVERAGES YANG GO PUBLIC DI BURSA EFEK JAKARTA

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    SUTEJO - -

    2012-05-01

    Full Text Available ABSTRAK Ide penelitian ini didasarkan pada kenyataan bahwa para investor bersedia melakukan investasi, kalau obyek investasi tersebut mampu menghasilkan keuntungan yang lebih tinggi dari obyek investasi lainya, sehingga perusahaan yang go public harus menarik bagi calon investor. Earnings per share merupakan salah satu indikator utama yang digunakan investor dalam melihat daya tarik suatu saham. Informasi ini akan bermanfaat bagi pengambilan keputusan di bidang keuangan pada industri food and baverages yang menjual sahamnya di Bursa Efek Jakarta. Tujuan penelitian ini adalah untuk mengidentifikasi pengaruh variabel-variabel return on equity (X1, net sales (X2, current ratio (X3, debt to equity (X4, inventory turnover (X5, total assets turnover (X6, dan net profit margin (X7 terhadap earnings per share, baik secara simultan maupun secara partial. Penelitian ini dilakukan dengan mengambil keseluruhan elemen populasi industri food and baverages yang go public di Bursa Efek Jakarta, mulai tahun 1992 sampai dengan tahun 1996 dengan rincian sebagai berikut: tahun 1992 berjumlah 9 perusahaan, tahun 1993 berjumlah 15 perusahaan, tahun 1994 berjumlah 19 perusahaan, tahun 1995 berjumlah 20 perusahaan dan tahun 1996 berjumlah 20 perusahaan. Analisis yang digunakan dalam penelitian ini adalah analisis regresi berganda, dengan hasil sebagai berikut : Pertama, return on equity (X1, net sales (X2, current ratio (X3, debt to equity (X4, inventory turnover (X5, total assets turnover (X6, dan net profit margin (X7 secara simultan berpengaruh dalam menentukan variabilitas earnings per share. Kedua, diantara berbagai variabel bebas tersebut hanya inventory turnover (X5 yang tidak berpengaruh secara signifikan dalam menentukan variabilitas earnings per share, hal ini tentunya tidak terlepas dari kenyataan pada industri food and baverages di Indonesia, dimana untuk menjamin kelancaran dan kualitas bahan baku yang dibeli, perusahaan harus memberikan bantuan teknis

  13. PENGARUH CORPORATE SOCIAL RESPONSIBILITY INDEKS TERHADAP KINERJA PERUSAHAAN (STUDY PADA PERUSAHAAN INFRASTRUKTUR, UTILITAS, DAN TRANSPORTASI YANG LISTING DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Ika Mar’atus Sholihah

    2013-10-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui pengaruh corporate social responsibility indeks terhadap kinerja perusahaan. Dalam penelitian ini, kinerja keuangan perusahaan diukur dengan menggunakan ROA (Return On Asset. Sampel yang digunakan dalam penelitian ini adalah semua perusahaan infrastruktur, utilitas, dan transportasi yang listing di Bursa Efek Indonesia dan menerbitkan annual report pada tahun 2010-2012 di website www.idx.co.id dengan menggunakan metode purposive judgemen. Metode analisis yang digunakan pada penelitian regresi berganda. Berdasarkan hasil pengujian, ditemukan bahwa variabel corporate social responsibility (CSR berpengaruh positif terhadap kinerja perusahaan. Sementara hasil uji signifikasi diketahui corporate social responsibility indeks secara parsial tidak berpengaruh terhadap kinerja perusahaan, hanya variabel kontrol leverage saja yang berpengaruh secara signifikan terhadap kinerja perusahaan

  14. ANALISIS PERBANDINGAN KEMAMPUAN PREDIKSI KEBANGKRUTAN ANTARA ANALISIS ALTMAN, ANALISIS OHLSON DAN ANALISIS ZMIJEWSKI PADA SEKTOR INDUSTRI TEKSTIL YANG GO PUBLIC DI BURSA EFEK INDONESIA PERIODE 2008-2012

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    Bethani Suryawardani

    2016-03-01

      Abstrak - Penelitian ini bertujuan untuk mengetahui perbedaan antara Altman Modifikasi Model, Model Zmijewski dan Model Ohlson dalam memprediksi kebangkrutan pada perusahaan Tekstil dan Garment yang terdaftar di Bursa Efek Indonesia dari tahun 2008 sampai 2012. Metode penelitian yang digunakan dalam penelitian ini adalah deskriptif komparatif untuk menjelaskan dan membandingkan tiga metode untuk prediksi kebangkrutan. Hasil penelitian ini menunjukkan bahwa Metode Ohlson (O-Score terbukti lebih akurat dalam memprediksi kebangkrutan (kesulitan keuangan, terutama untuk Industri Tekstil dan Garmen karena memiliki akurasi yang lebih tinggi yaitu dengan tingkat probabilitas akurasi 97,8%, itu dibuktikan dengan hasil perhitungan, dimana hanya perusahaan HDTX pada tahun 2011 yang tidak diprediksi bangkrut di masa depan. Sedangkan metode Altman Modifikasi (Z" Score hanya dapat memprediksi kondisi kesulitan keuangan (financial distress untuk perusahaan dengan akurasi 73,3%. Model Zmijewski (X-Score dapat memprediksi kebangkrutan bagi perusahaan sebesar 60% selama periode penelitian.   Kata Kunci: Kebangkrutan, Altman Modifikasi, Ohlson, Zmijewski, Kesulitan Keuangan

  15. MRI of adhesive capsulitis of the shoulder: Distension of the bursa in the superior subscapularis recess is a suggestive sign of the pathology

    Energy Technology Data Exchange (ETDEWEB)

    Carbone, Stefano, E-mail: stefcarbone@yahoo.it [Department of Orthopaedic and Traumatology, University of Rome Sapienza (Italy); Napoli, Alessandro [Department of Radiologic Sciences, University of Rome Sapienza (Italy); Gumina, Stefano [Department of Orthopaedic and Traumatology, University of Rome Sapienza (Italy)

    2014-02-15

    Objective: To evaluate the diagnostic values of the superior subscapularis recess sign in patients with shoulder adhesive capsulitis. The sign consists in evaluating in MRI of the shoulder the presence of fluid distension of the bursa in the superior subscapularis recess. Materials and methods: We evaluated MRI of 165 shoulders in 48 consecutive patients with a diagnosis of shoulder adhesive capsulitis in the freezing phase (group I), in 49 short-wide superior cuff tear (group II) and in 65 controls (group III) between 2010 and 2013. On the T2 weighted images, we evaluated the presence of an high intensity signal within the superior subscapularis recess, consistent with fluid distension of the bursa. Results: The sign was found in 43/48 patients (89.58%) with shoulder adhesive capsulitis in 3/49 (6.12%) patients with superior cuff tear and in 1/65 controls (1.53%) (p < 0.001). The mean diagnostic values were: sensibility 0.91; specificity 0.96–0.98; positive predictive value 0.93–0.97; negative predictive value 0.92–0.94; likelihood ratios for an abnormal test result 15.16–60.6; likelihood ratios for a normal test result 0.086–0.095. Conclusion: For the orthopedic surgeon or the clinician, the sign is useful to confirm in MRI the clinical diagnosis of shoulder adhesive capsulitis; accordingly, the radiologist should describe and relate this sign to the pathology in the report, looking eventually for further typical sign of shoulder adhesive capsulitis.

  16. Antibacterial activity of Tribulus terrestris and its synergistic effect with Capsella bursa-pastoris and Glycyrrhiza glabra against oral pathogens: an in-vitro study

    Science.gov (United States)

    Soleimanpour, Saman; Sedighinia, Fereshteh Sadat; Safipour Afshar, Akbar; Zarif, Reza; Ghazvini, Kiarash

    2015-01-01

    Objective: In this study, antimicrobial activities of an ethanol extract of Tribulus terrestris aloneand in combination with Capsella bursa-pastoris and Glycyrrhiza glabra were examined in vitro against six pathogens namely Streptococcus mutans, Streptococcus sanguis, Actinomyces viscosus, Enterococcus faecalis Staphylococcus aureus, and Escherichia coli. Materials and methods: Antibacterial activities of the extracts were examined using disc and well diffusion methods and the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of ethanol extracts were determined against these microorganisms using agar and broth dilution methods. Chlorhexidine was used as positive control. Results: Tribulus terrestris extract exhibited good antibacterial activity against all bacteria. Antibacterial activity of mixed extract was evaluated and exhibited that mixed extract was more effective against all bacteria than any of the cases alone which indicates the synergistic effect between these three extracts (p˂0.05). No strain showed resistance against these extracts. In agar dilution, Tribulus terrestris exhibited MIC values ranging from 35.0 to 20.0 mg/ml and mixed extract showed MIC values ranging from 12.5 to 5.0 mg/ml. The results of broth dilution method were consistent with the findings of the agar dilution method. Conclusion: This in-vitro study was a preliminary evaluation of antibacterial activity of the plants. It provided scientific evidence to support uses of T. terrestris and its mixture with C. bursa-pastoris and G. glabra for the treatment of oral infections. In-vivo studies are also required to better evaluate the effect of these extracts. PMID:26101754

  17. Testing some of Benjamin Graham’s Stock Selection Criteria: A Case of the FTSE Bursa Malaysia EMAS Index from Year 2000 to 2009

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    Desmond Chang

    2011-01-01

    Full Text Available Benjamin Graham, also known as the “father of value investing” proposed that investment in the stock exchange can be a safe endeavor while receiving gains that outperform the market if the investor makes carefully thought out purchases. This study aims to determine if the use of some of Benjamin Graham’s stock selection criteria is able to generate returns that are significantly greater than the returns in the stock exchange of Malaysia, particularly, the comprehensive FTSE Bursa Malaysia EMAS Index. This study collected secondary data regarding fundamentals of companies listed in the FTSE Bursa Malaysia EMAS Index from the year 2000 to 2009. Five criteria were set up in this research based on one or a combination of price-to-earnings ratio, price-to-book value, current ratio and dividend yield. The listed companies were screened using those criteria. An equally weighted portfolio was created using the screened companies and their one-year and two-year returns calculated. The returns were compared to the market return. Hypotheses of this research were tested using t-test statistic to determine the significance of the data. This research found that most of the screening criteria used generated returns that were higher than the market return in almost every year they were tested in. Benjamin Graham’s stock selection criteria although have been conceived over 80 years ago is still applicable today in the Malaysian market. Further research can be conducted with different criteria with varying holding periods and in different markets.

  18. Antibacterial activity of Tribulus terrestris and its synergistic effect with Capsella bursa-pastoris and Glycyrrhiza glabra against oral pathogens: an in-vitro study

    Directory of Open Access Journals (Sweden)

    Saman Soleimanpour

    2015-04-01

    Full Text Available Objective: In this study, antimicrobial activities of an ethanol extract of Tribulus terrestris aloneand in combination with Capsella bursa-pastoris and Glycyrrhiza glabra were examined in vitro against six pathogens namely Streptococcus mutans, Streptococcus sanguis, Actinomyces viscosus, Enterococcus faecalis Staphylococcus aureus, and Escherichia coli. Materials and methods: Antibacterial activities of the extracts were examined using disc and well diffusion methods and the minimum inhibitory concentration (MIC and minimum bactericidal concentration (MBC of ethanol extracts were determined against these microorganisms using agar and broth dilution methods. Chlorhexidine was used as positive control. Results: Tribulus terrestris extract exhibited good antibacterial activity against all bacteria. Antibacterial activity of mixed extract was evaluated and exhibited that mixed extract was more effective against all bacteria than any of the cases alone which indicates the synergistic effect between these three extracts (p˂0.05. No strain showed resistance against these extracts. In agar dilution, Tribulus terrestris exhibited MIC values ranging from 35.0 to 20.0 mg/ml and mixed extract showed MIC values ranging from 12.5 to 5.0 mg/ml. The results of broth dilution method were consistent with the findings of the agar dilution method. Conclusion: This in-vitro study was a preliminary evaluation of antibacterial activity of the plants. It provided scientific evidence to support uses of T. terrestris and its mixture with C. bursa-pastoris and G. glabra for the treatment of oral infections. In-vivo studies are also required to better evaluate the effect of these extracts.

  19. Molecular cloning and functional analysis of peafowl (Pavo cristatus) Toll-like receptor 7.

    Science.gov (United States)

    Song, H; Zhang, M; Gao, W; Wu, L; Li, G

    2018-01-01

    In order to clone the peafowl (Pavo cristatus) Toll-like receptor 7 (TLR7) gene and study its biological function, the peafowl TLR7 coding sequences (CDS) were amplified by PCR of cDNA from the whole spleen of peafowl. The full-length sequence of the peafowl TLR7 gene CDS is 3,141 bp and encodes a 1,046-amino acid protein with a classic TLR composition of 16 leucine-rich repeats (LRR). Insertions of amino acids were found at position 15 of LRR2, LRR5, LRR7, LRR9, LRR11, LRR12, LRR14, and LRR15; and position 10 of LRR11. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis showed that the peafowl TLR7 gene was highly expressed in lymphoid tissues of the spleen, bursa, bone marrow, lung, and peripheral blood mononuclear cells (PBMC). HEK293T cells were transfected with a peafowl TLR7 plasmid, and functional analysis showed that peafowl TLR7 could respond to R848, leading to activation of NF-κB. Following R848 stimulation or Newcastle disease virus infection of peafowl PBMC, the levels of IL-1β, IFN-γ, CCLi2, and TGF-β4 mRNA, assessed by quantitative real-time PCR, increased significantly. Triggering peafowl TLR7 results in upregulation of inflammatory cytokines and chemokines, suggesting that peafowl TLR7 plays an important role in the innate immune response. © 2017 Poultry Science Association Inc.

  20. ANALISIS VARIABEL YANG MEMPENGARUHI EARNINGS PER SHARE PADA INDUSTRI FOOD AND BAVERAGES YANG GO PUBLIC DI BURSA EFEK JAKARTA

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    Sutejo - -

    2012-05-01

    Full Text Available ABSTRAK Tujuan penelitian ini adalah untuk mengidentifikasi pengaruh variabel-variabel return on equity (X1, net sales (X2, current ratio (X3, debt to equity (X4, inventory turnover (X5, total assets turnover (X6, dan net profit margin (X7 terhadap earnings per share, baik secara simultan maupun secara partial. Penelitian ini dilakukan dengan mengambil keseluruhan elemen populasi industri food and baverages yang go public di Bursa Efek Jakarta, mulai tahun 1992 sampai dengan tahun 1996 dengan rincian sebagai berikut: tahun 1992 berjumlah 9 perusahaan, tahun 1993 berjumlah 15 perusahaan, tahun 1994 berjumlah 19 perusahaan, tahun 1995 berjumlah 20 perusahaan dan tahun 1996 berjumlah 20 perusahaan. Hasil penelitian menunjukkan bahwa return on equity (X1, net sales (X2, current ratio (X3, debt to equity (X4, inventory turnover (X5, total assets turnover (X6, dan net profit margin (X7 secara simultan berpengaruh dalam menentukan variabilitas earnings per share. Variabel inventory turnover (X5 tidak mempengaruhi variabilitas earnings per share, hal ini tentunya tidak terlepas dari kenyataan pada industri food and baverages di Indonesia, dimana untuk menjamin kelancaran dan kualitas bahan baku yang dibeli, perusahaan harus memberikan bantuan teknis maupun modal kerja kepada para supplier lokal, sehingga perusahaan harus menyediakan modal atau kredit lunak dalam rangka kerja sama yang saling menguntungkan. Di sisi lain bahan baku industri food and baverages dalam prakteknya dipengaruhi oleh keberhasilan dan kegagalan panen para supplier, sehingga dari berbagai kendala yang dihadapi industri food and baverages tersebut sebagai akibatnya kadang-kadang bahan baku melimpah dan tidak jarang mengalami kekurangan atau menghadapi kelangkaan. Oleh karena itu tingginya tingkat perputaran persediaan tidak dapat menunjukan efisiensi perusahaan. Diantara variabel bebas yang berpengaruh signifikan tersebut net sales (X2, dan current ratio (X3 mempunyai pengaruh

  1. Bursa'da Tüketime Sunulan Bazı Gıdalarda Yersinia enterocolitica 'nın Varlığının Araştırılması

    OpenAIRE

    Evrensel, Süreyya Saltan; Yüksek, Nur; Temelli, Seran

    2006-01-01

    A toal of 100 samples composed of various cheese types (white pickled cheese, kashar, tulum, mihalic, processed and curd cheese) and meat products (ground beef, meat balls, fermented-pasteurized sausage and sausage) purchased from supermarkets in Bursa, were examined for the presence of Yersinia enterocolitica (Y. enterocolitica). Six out of 100 of these samples were found to be Y. enterocolitica positive. Y. enterocolitica was identified in 2 of the white pickled cheese, 2 of the ground beef...

  2. Thermoresponsive polymer nanoparticles co-deliver RSV F trimers with a TLR-7/8 adjuvant

    Czech Academy of Sciences Publication Activity Database

    Francica, J. R.; Lynn, G. M.; Laga, Richard; Joyce, M. G.; Ruckwardt, T. J.; Morabito, K. M.; Chen, M.; Chaudhuri, R.; Zhang, B.; Sastry, M.; Druz, A.; Ko, K.; Choe, M.; Pechar, Michal; Georgiev, I. S.; Kueltzo, L. A.; Seymour, L. W.; Mascola, J. R.; Kwong, P. D.; Graham, B. S.; Seder, R. A.

    2016-01-01

    Roč. 27, č. 10 (2016), s. 2372-2385 ISSN 1043-1802 R&D Projects: GA ČR(CZ) GJ16-14957Y; GA MŠk(CZ) LQ1604 Institutional support: RVO:61389013 Keywords : thermoresponsive polymers * polymer vaccines * toll-like receptor agonists Subject RIV: CD - Macromolecular Chemistry Impact factor: 4.818, year: 2016

  3. 2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation.

    Science.gov (United States)

    Weterings, Jimmy J; Khan, Selina; van der Heden van Noort, Gerbrand J; Melief, Cornelis J M; Overkleeft, Herman S; van der Burg, Sjoerd H; Ossendorp, Ferry; van der Marel, Gijsbert A; Filippov, Dmitri V

    2009-04-15

    The synthesis of an array of 2-azidoalkoxy substituted 7-hydro-8-oxoadenines is described. The relation of the structure of these compounds and their ability to induce maturation of dendritic cells is evaluated.

  4. Pengaruh Struktur Kepemilikan Saham Leverage Faktor Intern Dan Faktor Ekstern Terhadap Nilai Perusahaan (Studi empirik pada perusahaan manufaktur dan non manufaktur di Bursa Efek Jakarta

    Directory of Open Access Journals (Sweden)

    Sujoko

    2007-01-01

    Full Text Available The main objective of the study is to examine the impact of ownership structure%2C leverage%2C external factor%2C internal factor on the value of the firms in Jakarta Stock Exchange. It is argued that unlike the agency problem advanced stock market%2C the agency problem in the Jakarta Stock Exchange is the divergence of interest between the minority holders and majority holders. This is because the Jakarta Stock Exchange is characterized%2C among other things%2C by the domination of large shareholders. It is hypotheses that :(1 there are the impact ownership structure %2C external factor%2C internal factor%2C on leverage%2C (2 there are the impact of ownership structure %2C external factor%2C internal factor%2C leverage on value of the firm . This study is to examine Agency Theory%2C Jensen and Meckling (1976%2C Pecking Order Theory%2C Myers (1984%2C Trade Off Model and Signaling Theory (1979. Population in this study are public company listed in Jakarta Stock Exchange during 2000 – 2004. As much as 134 firms listed in Jakarta Stock Exchange were taken as a sample using a purposive sampling method.The data were then analyzed by the structural equation modeling ( SEM analysis%2C using the AMOS Program version 4.01.The results of this study show that (1 there are the impact of ownership structure %2C external factor%2C internal factor on leverage%2C(2there are the impact of ownership structure%2C external factor%2C internal factor%2C leverage%2C on valueof the firm . The result of the study is not support the Agency Theory%2C Jensen and Meckling (1976%2C but the result of the study is support Pecking Order Theory%2C Myers (1984%2C Trade off model and Signaling Theory%2C Battacharya (1979. Abstract in Bahasa Indonesia : Tujuan utama dari studi ini adalah untuk menguji pengaruh struktur kepemilikan%2C leverage%2C faktor ekstern%2C dan faktor intern terhadap nilai perusahaan di Bursa Efek Jakarta. Tidak seperti pada permasalahan keagenan di pasar

  5. Vascular endothelial growth factor 121 and 165 in the subacromial bursa are involved in shoulder joint contracture in type II diabetics with rotator cuff disease.

    Science.gov (United States)

    Handa, Akiyoshi; Gotoh, Masafumi; Hamada, Kazutoshi; Yanagisawa, Kazuhiro; Yamazaki, Hitoshi; Nakamura, Masato; Ueyama, Yoshito; Mochida, Joji; Fukuda, Hiroaki

    2003-11-01

    Vascular endothelial growth factor (VEGF) is a glycoprotein that plays an important role in neovascularization and increases vascular permeability. We reported that VEGF is involved in motion pain of patients with rotator cuff disease by causing synovial proliferation in the subacromial bursa (SAB). The present study investigates whether VEGF is also involved in the development of shoulder contracture in diabetics with rotator cuff disease. We examined 67 patients with rotator cuff disease, including 36 with complete cuff tears, 20 with incomplete tears, and 11 without apparent tears (subacromial bursitis). The patients were into groups according to the presence or absence of diabetes (14 type II diabetics and 53 non-diabetics). Specimens of the synovium of the SAB were obtained from all patients during surgery. Expression of the VEGF gene in the synovium of the subacromial bursa was evaluated by using the reverse transcriptase polymerase chain reaction. The VEGF protein was localized by immunohistochemistry, and the number of vessels was evaluated based on CD34 immunoreactivity. The results showed that VEGF mRNA was expressed in significantly more diabetics (100%, 14/14) than in non-diabetics (70%, 37/53) (P=0.0159, Fisher's test). Investigation of VEGF isoform expression revealed VEGF121 in all 14 diabetics and in 37 of the 53 non-diabetics, VEGF165 in 12 of the 14 diabetics and in 21 of the 53 non-diabetics, and VEGF189 in 1 of the 14 diabetics and in 2 of the 53 non-diabetics. No VEGF206 was expressed in either group. VEGF protein was localized in both vascular endothelial cells and synovial lining cells. The mean number of VEGF-positive vessels and the vessel area were also significantly greater in the diabetics (pshoulder joint contracture were more common in the diabetics (P=0.0329 and P=0.073, respectively; Fisher's test). The mean preoperative range of shoulder motion significantly differed in terms of elevation between two groups: 103.8 degrees in

  6. Lipoma arborescens: caso raro de ruptura do manguito rotador associado à presença de lipoma arborescens na bursa subacromial-subdeltoidea e glenoumeral Lipoma arborescens: rare case of rotator cuff tear associated with the presence of lipoma arborescens in the subacromial-subdeltoid and glenohumeral bursa

    Directory of Open Access Journals (Sweden)

    Eduardo Benegas

    2012-01-01

    Full Text Available Lipoma arborescens é uma condição rara de moléstia intra-articular, usualmente monoarticular, caracterizada por extensa proliferação dos vilos sinoviais e hiperplasia da gordura subsinovial. O tecido sinovial é progressivamente substituído por células maduras de gordura na membrana sinovial. O presente trabalho é o relato de caso de uma condição rara de lipoma arborescens tanto intra-articular (glenoumeral como da bursa subacromial-subdeltoide além de ruptura do tendão do supraespinhoso. As apresentações clínicas, histológicas e radiográficas assim como o tratamento são discutidos no presente estudo. A apresentação do caso contempla também a avaliação radiográfica, ressonância magnética e exame patológico. Apesar do lipoma arborescens ser uma condição rara, tal hipótese deve ser considerada frente a um caso com hiperproliferação sinovial e lipossubstituição da sinovial.Lipoma arborescens is a rare intra-articular disease that is usually monoarticular and is characterized by extensive proliferation of the synovial villi and hyperplasia of the subsynovial fat. The synovial tissue is progressively replaced by mature fat cells in the synovial membrane. The present study reports a case of a rare condition of lipoma arborescens that was simultaneously intra-articular (glenohumeral joint and in the subacromial-subdeltoid bursa, in association with a torn supraspinatus tendon. The clinical, histological and radiographic presentations and treatment are discussed here. The description of this case includes radiographic and magnetic resonance evaluations and pathological examination. Although lipoma arborescens is a rare condition, it should be taken into consideration in cases presenting synovial hyperproliferation and synovial fat replacement.

  7. Effects of turmeric (Curcuma longa) and vitamin E on histopathological lesions induced in bursa of Fabricius of broiler chicks by salinomycin.

    Science.gov (United States)

    Sayrafi, Reza; Mirzakhani, Navideh; Mobaseri, Reza

    2017-01-01

    The aim of this study was to evaluate the protective effects of the turmeric in comparison to vitamin E on bursal damages induced by salinomycin in broiler chickens. In this study, forty one day-old broiler chicks were randomly divided into four treatment groups: 1- basal diet as control, 2- basal diet plus salinomycin, 3- basal diet plus salinomycin (SLM) and vitamin E (Vit. E) and 4- basal diet plus salinomycin and turmeric powder. The chicks were treated for two weeks. At the end of the experiment, the bursal tissues were removed and fixed in 10% formalin solution. Tissue sections were stained with hematoxylin and eosin stain for histopathological studies. Light microscopic observations showed that, SLM diminished cortex thickness of bursal tissue, enhanced its medulla zone and caused severe lymphocytic necrosis. In addition, SLM led to fibrosis of interstitium along with sever edema of medulla zone in the bursal tissue of the chicken. Administration of Vit. E and TP significantly inhibited the SLM-induced derangements and comparing the Vit. E and TP showed no significant differences. The results of this study indicated that the turmeric may protect bursa of Fabricius against toxicity induced by salinomycin in chicks.

  8. Muscle shortening maneuver and not topical anti-inflammatory therapy is effective in reducing the width of subacromial-subdeltoid bursa in shoulder impingement syndrome

    Science.gov (United States)

    Melchiorre, Daniela; Lippi, Paolo; Marchi, Alberto; Maresca, Marco; Bravi, Riccardo; Eros, Quarta; Lazzerini, Patrizia; Bagni, Maria Angela

    2018-04-01

    Aim of the study was to compare the efficacy of a muscle shortening maneuver (MSM) with the efficacy of a topical NSAID (flurbiprofen) in patients with subacromial impingement syndrome (SIS). The effects of these therapies were evaluated by sonographic exam (US). SIS was diagnosed by US in 78 patients with painful shoulder. Thirty patients (first group) were treated with topical flurbiprofen for 15 days. Forty-eight patients (second group) were treated with MSM, which was performed once. The shoulder was analyzed in all patients by US before and after treatment. Before treatment and 15 days after treatment, pain by Visual Analogue Scale (VAS), range of motion (ROM) and Neer's Test were evaluated. Pain was decreased by both treatments. In only 8 patients of the first group, the encroachment of acromion into the rotator cuff was no more detectable by US after the treatment; ROM increased (> 45°) only in 11 patients (36%) and the width of subacromial-subdeltoid bursa (SSB) was not significantly reduced. At variance with the results obtained in the first group, in all patients of the second group the encroachment of acromion was no more detectable by US, ROM increased (> 45°) and the width of SSB was significantly reduced after the maneuver. Both topical flurbiprofen and MSM were helpful in pain control, but better results, with decrease of width of SSB assessed by US, were obtained by MSM.

  9. Verbascum bombyciferum Boiss. (Scrophulariaceae) as possible bio-indicator for the assessment of heavy metals in the environment of Bursa, Turkey.

    Science.gov (United States)

    Arslan, Hülya; Güleryüz, Gürcan; Leblebici, Zeliha; Kirmizi, Serap; Aksoy, Ahmet

    2010-04-01

    In this study, we determined the heavy metal content (Cd(2+), Cr(3+), Cu(2+), Fe(3+), Ni(2+), Pb(2+), and Zn(2+)) in the soil surrounding the roots and different organs of Verbascum bombyciferum Boiss. (Scrophulariaceae), which is endemic to Uludağ Mountain, Bursa, Turkey. Plant samples were collected from roadsides, and heavy metal accumulation capabilities were tested. This is one of the pioneer species of ruderal plant communities on roadsides, building sites, rubbish dumps, etc. Different organs of plant samples (roots, stems, leaves, and flowers) and their soils were analyzed by inductively couple plasma optical emission spectroscopy for their heavy metal contents. Some of the analyzed heavy metals (Cd(2+), Cr(3+), Pb(2+), and Zn(2+)) were usually increased depending on the traffic in the sample sites, and this variation was also reflected in heavy metal content of plant samples. Our results show that this plant can be used as a bio-indicator species in the monitoring of increased Cd(2+), Cr(3+), Pb(2+), and Zn(2+) in the environment. We also concluded that V. bombyciferum have the capability of Cd(2+), Cr(3+), Cu(2+), Ni(2+), Pb(2+), and Zn(2+) accumulation.

  10. CbRCI35, a cold responsive peroxidase from Capsella bursa-pastoris regulates reactive oxygen species homeostasis and enhances cold tolerance in tobacco

    Directory of Open Access Journals (Sweden)

    Juan Lin

    2016-10-01

    Full Text Available Low temperature affects gene regulatory networks and alters cellular metabolism to inhibit plant growth. Peroxidases are widely distributed in plants and play a large role in adjusting and controlling reactive oxygen species (ROS homeostasis in response to abiotic stresses such as low temperature. The Rare Cold-Inducible 35 gene from Capsella bursa-pastoris (CbRCI35 belongs to the type III peroxidase family and has been reported to be a cold responsive gene in plants. Here we performed an expressional characterization of CbRCI35 under cold and ionic liquid treatments. The promoter of CbRCI35 was also cloned and its activity was examined using the GUS reporter system. CbRCI35 protein was localized in the cytoplasm according to sequence prediction and GFP fusion assay. Heterologous expression tests revealed that CbRCI35 conferred enhanced resistance to low temperature and activated endogenous cold responsive signaling in tobacco. Furthermore, in the normal condition the ROS accumulation was moderately enhanced while after chilling exposure superoxide dismutase (SOD activity was increased in CbRCI53 transgenic plants. The ROS metabolism related genes expression was altered accordingly. We conclude that CbRCI35 modulates ROS homeostasis and contributes to cold tolerance in plants.

  11. PENGARUH PROFIT MARGIN, ASSETS TURNOVER DAN LEVERAGE TERHADAP SUSTAINABLE GROWTH RATE PADA PERUSAHAAN SEKTOR JASA YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2010-2012

    Directory of Open Access Journals (Sweden)

    Arim Nasim

    2015-04-01

    Full Text Available This study aims to determine the effect of Profit Margin, Assets Turnover and Leverage on Sustainable Growth Rate. The variables used are profit margin, asset turnover and leverage as independent variable and sustainable growth rate as dependent variable. This study also aims to describe the state of profit margin projected by Net Profit Margin (NPM, asset turnover proxied by Total Assets Turnover (TATO, leverage which is proxied by Debt to Equity Ratio (DER and Sustainable Growth Rate (SGR Service sector. This research was conducted on service sector companies listed in Indonesia Stock Exchange 2010-2012.Data obtained from website Bursa Efek Indonesia.Teknik data analysis used is multiple linear regression and use t-statistics to test the influence of each independent variable to variable Dependent partially.Previously done classical assumption test that includes data normality test, multicolinierity test, heteroskedastisitas test and autocorrelation test.Based on data normality test, multicolinierity test, heteroscedasticity test and autocorrelation test did not found any variables that deviate from the classical assumption.From the results of research Shows that profit margin positively affect sustainable growth rate, asset turnover have positive effect to sustainable growth rate, and leverage have positive effect to sustainable growth rate.

  12. Use Of New Media In The Local Press: Comparative Analysis Of Local Newspapers Websites In İzmir, Adana and Bursa

    Directory of Open Access Journals (Sweden)

    Berrin Kalsin

    2016-01-01

    Full Text Available Local press is defined as a press that serves to introduce and train the public and to provide the public opinion.  Local press gives information about the cases happen around the region that it is published and it forms public opinion about the problems of that region.  New communication technologies havehave an important role in the forming and enhancing the news contents in the media. Changeovers have occurred in the production,  process and distributiondistribution of the news by developing the new media. On the other hand,  Internet journalism used by many press institutions is occurredoccurred as a new concept in mass communication.  National and local newspapers do not remain insensitive to this new mass communication and it attempts the Internet journalism. Firstly,  pressed newspaper had been turned into Web sites as similar but later new application about the transferring the news to the reader have occurred when we look at this application about the transferring of the pressed newspaper to the Internet environment.  In this study, the Internet websites if Adanaher from Adana,  Olay from Bursa and Ege'nin Sesi from Izmir have been compared with each other.  The form, content and interaction of these three newspapers have been discussed and the usage of social media and importance given to the local news have been analyzed.

  13. Food composition of Uludağ frog, Rana macrocnemis Boulenger, 1885 in Uludağ (Bursa, Turkey

    Directory of Open Access Journals (Sweden)

    Kerim CICEK

    2011-06-01

    -ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} --> Feeding habit and food preferences of Uludağ frog, Rana macrocnemis were studied in 2006 and 2007 in Uludağ (Bursa, Turkey. Stomach contents of 165 (87 ♂♂, 58 ♀♀, 20 juveniles individuals were analyzed and a total of 2,129 preys were determined. It was found that the species fed mainly on a variety of invertebrates and especially on insects (96.5%. The most frequently consumed preys were Coleoptera (62.8%, Diptera (14.4%, and Hymenoptera (9.8%. It was observed that there was no significant sex- and age-dependent difference in the feeding regime. The species was found to feed less in the breeding period and more in the post-breeding period. It was also striking that there was an increase in the consumption of Coleoptera depending on elevation. In conclusion, the species is an opportunistic and widely-foraging predator that feeds on terrestrial and aquatic insects and its food composition varies by the availability of prey items around it.

  14. Analisis Fundamеntal untuk Mеnilai Kеwajaran Harga Saham Dеngan Pеndеkatan Discountеd Cash Flow (Studi pada Pеrusahaan Dеngan Kapitalisasi Pasar Tеrbеsar dari Jakarta Islamic Indеx dan Ftsе Bursa Malaysia Hijrah Shariah Indеx Pеriodе 2011-2015)

    OpenAIRE

    Jatnika, Oktana Indriyatna; Nuzula, Nila Firdausi

    2017-01-01

    Thе rеsеarch is conductеd to find out thе fairnеss of sharе pricе of sharia companiеs listеd in Bursa Еfеk Indonеsia and Bursa Malaysia and to givе rеcommеndation rеlatеd to thе valuation rеsult obtainеd by using fundamеntal analysis of Discountеd Cash Flow (DCF) approach. Thе rеsеarch typе is dеscriptivе rеsеarch with quantitativе approach. Thе population in this study arе all companiеs listеd in Jakarta Islamic Indеx (JII) and FTSЕ Bursa Malaysia Hijrah Shariah Indеx (FBMHS) in 2015. Total ...

  15. PENGARUH LABA BERSIH, ARUS KAS OPERASIONAL, INVESTMENT OPPORTUNITY SET DAN FIRM SIZE TERHADAP DIVIDEN KAS (Studi Kasus Pada Perusahaan Manufaktur di Bursa Efek Indonesia Tahun 2010 – 2012

    Directory of Open Access Journals (Sweden)

    Luluk Muhimatul Ifada

    2014-12-01

    Full Text Available This study aimed to investigate the influence of net profit, operating cash flow, investment opportunity set, and firm size on cash dividend. The sample of this research is manufacturing companies list on Indonesia Stock Exchange (BEI in period 2010-2012 published by www.idx.co.idand posted at Indonesia Capital Market Directory (ICMD. There are 28 acquired companies that meet the criteria specified. The analysis method use multiple regression analysis with level of significance 5%. The conclusion of this research based on  t-statistic result.The result of this research proved that variable net profit have significantly positive influence on cash dividend. Operating cash flow have significantly positive influence on cash dividend. Investment opportunity set hasn’t significantly and have negative correlation influence towards cash dividend. Firm size hasn’t significantly but have positive correlation influence toward cash dividend.Penelitian   ini   bertujuan   untuk   menganalisis   pengaruh   laba   bersih, arus kas operasi, investment opportunity set, dan firm size terhadap dividen kas. Sampel penelitian ini adalah perusahaan manufaktur yang terdaftar di Bursa EfekIndonesia periode tahun 2010-2012. Data yang digunakan adalah laporan keuangan dari masing-masing perusahaan sampel, yang dipublikasikan melalui website www.idx.co.id. dan termuat dalam Indonesia Capital Market Dierctory (ICMD. Data yang memenuhi kriteria penelitian terdapat 28 perusahaan. Penelitian ini menggunakan alat uji statistik dengan pendekatan analisis regresi linier berganda dengan tingkat signifikansi 5%. Kesimpulan pengujian diambil berdasarkan hasil uji t-Statistik. Hasil pengujian ini menunjukkan bahwa pengujian pada variabel laba bersih terhadap dividen kas terbukti berpengaruh positif dan signifikan. Pengujian pada variabel arus kas operasional terhadap dividen kas terbukti berpengaruh positif dan signifikan.Pengujian pada variabel investment

  16. Targeted knockout of TNF-α by injection of lentivirus-mediated siRNA into the subacromial bursa for the treatment of subacromial bursitis in rats.

    Science.gov (United States)

    Wang, Yi; Li, Quan; Wei, Xianzhao; Xu, Jie; Chen, Qi; Song, Shuang; Lu, Zhe; Wang, Zimin

    2015-09-01

    Subacromial bursitis (SAB) is the major source of pain in rotator cuff disease. Although multiple investigations have provided support for the role of inflammatory cytokines in SAB, few have focussed on the use these cytokines in the treatment of SAB. The aim of the present study was to observe the therapeutic efficacy of lentivirus‑mediated RNA interference (RNAi) on carrageenan‑induced SAB by injecting lentivirus‑tumor necrosis factor (TNF)‑α‑RNAi expressing TNF‑α small interfering (si)RNA. Using screened siRNA segments, an siRNA was designed. A lentivirus vector expressing siRNA was established and packed as lentivirus particles. A lentivirus that expressed the negative sequence was used as a lentivirus‑negative control (NC). The carrageenan‑induced SAB model was established in 32 male Sprague‑Dawley rats. The modeled rats were randomly assigned to four groups: Lentivirus‑RNAi treatment group, lentivirus‑NC group, SAB group and phosphate‑buffered saline (PBS) blank control group. The lentivirus was injected (1x10(7) transducing units) into the subacromial bursa of the rats in the lentivirus‑RNAi group and lentivirus‑NC group, whereas 100 µl PBS was injected at the same site in the SAB group and the PBS blank control group. At 5 weeks following injection, the animals were sacrificed and venous blood was obtained. The effect of TNF‑α interference and the expression of inflammatory cytokines were determined by reverse transcription‑quantitative polymerase chain reaction, western blotting, hematoxylin and eosin staining, Van Gieson's staining and immunofluorescence. The expression of TNF‑α was decreased in the lentivirus‑TNF‑α‑RNAi group compared with that in the SAB group. Morphological observations revealed that the number of inflammatory cells were reduced and damage to tendon fibers was attenuated in this group, suggesting that the downregulation of the protein expression levels of TNF‑α‑associated nuclear

  17. One case report of pharyngeal bursa invasive fungal disease with lower cranial nerve involvement as the first manifestation%以后组脑神经受累为首要表现的咽囊侵袭性真菌病1例

    Institute of Scientific and Technical Information of China (English)

    陈静; 袁虎

    2013-01-01

    To increase the identification of pharyngeal bursa invasive fungal disease with lower cranial nerve involvement,reduce the misdiagnosis and improve the awareness of invasive fungal disease.We report the clinical data of a case with lower cranial nerve involvement as the first manifestation and reviewed the related literature.

  18. Changing trends in the development of bursa Fabricius of yellow quails%黄羽鹌鹑腔上囊发育的增龄变化

    Institute of Scientific and Technical Information of China (English)

    何敏; 汪开毓; 方静; 陈正礼; 唐丽; 邓天怀; 刘铁秋

    2011-01-01

    采用常规解剖组织学方法,对l~268d黄羽鹌鹑的腔上囊大小、绝对质量、生长指数进行测定及解剖组织结构分析,探讨了其形态、生长、组织学结构及发育规律,为鹌鹑的免疫接种和疾病研究提供理论基础。结果显示,黄羽鹌鹑腔上囊呈盲囊状,乳白色,位于肠道末端,泄殖腔背侧并与之相连;绝对质量、长和宽随日龄逐渐增大,39d最大,以后逐渐减小;生长指数随日龄增高,8d最高,以后逐渐下降;基本结构从内至外依次由黏膜、黏膜下层、肌层和浆膜组成,各层宽度及黏膜大褶皱高度于39d最大;组织构成随日龄逐渐发育,39d后逐渐纤维化萎缩,雌性比雄性退化的早且快,最后成为残迹。%By measuring the size,absolute weight,growth index of the bursa Fabricius(BF) and using routine HE method,the morphology,growth,histological structure and development of the BF in 1 to 268 days yellow quails were studied, which will provide basic and theoretical proof for the quail's immune capacity and disease resistance. The results demonstrated that the BF,lying in the end of intestinal tract, back of the cloaca and connecting with the latter,is ellipsoid and milk white. The absolute weight and size of the BF increased as the quails grew during the given period and reached the largest on the 39th day,it started to lose its original shape gradually at a later time. The growth index of the BF increased as the quails grew and reached its peak on the 8th day,then decreased gradually. Moreover,the basic structure of the BF from the outer layer to the inner one is made of mucous layer, submucous layer,muscular layer and serosa. The thickness of these layers and the height of the large plica reached the top on the 39th day. Composition of the organ gradually developed with the ages,fibrosis and atrophy gradually after the 39th day,and the degeneration of female quails' BF was earlier and faster than males' ,moreover

  19. PENGARUH RISIKO SISTEMATIS DAN RISIKO TIDAK SISTEMATIS TERHADAP EXPECTED RETURN SAHAM DALAM RANGKA PEMBENTUKAN PORTOFOLIO SAHAM LQ-45 YANG TERDAFTAR DI BURSA EFEK INDONESIA DENGAN SINGLE INDEX MODEL PERIODE TAHUN 2009

    Directory of Open Access Journals (Sweden)

    Ratih Paramitasari

    2015-04-01

    Tujuan dari penelitian ini adalah untuk menguji pengaruh risiko sistematis dan risiko sistematis pada hasil saham yang diharapkan portofolio terhadap perusahaan LQ45 dengan menggunakan model indeks tunggal. Populasi penelitian ini adalah semua saham yang tercatat pada Bursa Efek Indonesia. Sampel dari penelitian ini adalah saham dari kategori LQ45 dan ini ditentukan secara purposive sampling, dan itu terdiri dari 37 saham. Analisis data penelitian ini menggunakan analisis regresi berganda. Parsial dan simultan, hasilnya menunjukkan bahwa risiko sistematis dan risiko sistematis berpengaruh signifikan terhadap pengembalian yang diharapkan dari portofolio saham. Hasil ini menunjukkan perubahan variasi risiko sistematis dan risiko tidak sistematis digunakan untuk memprediksi perubahan variasi keuntungan yang diharapkan dari portofolio saham. Hasil ini sesuai dengan teori bahwa hubungan positif dan linier antara laba yang diharapkan dan risiko.

  20. Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and Tlr7) in wild rodents (MURINAE)

    Czech Academy of Sciences Publication Activity Database

    Fornůsková, Alena; Vinkler, M.; Pages, M.; Galan, M.; Jousselin, E.; Cerqueira, F.; Morand, S.; Charbonnel, N.; Bryja, Josef; Cosson, J.-F.

    2013-01-01

    Roč. 13, č. 194 (2013), s. 194 ISSN 1471-2148 R&D Projects : GA ČR GA206/08/0640 Institutional support: RVO:68081766 Keywords : Arms race * Host-pathogen interaction * Pattern recognition receptors * Adaptive evolution * Pathogen-Associated Molecular Pattern (PAMP) Subject RIV: EG - Zoology Impact factor: 3.407, year: 2013 http://www.biomedcentral.com/1471-2148/13/194

  1. First-line therapy for human cutaneous leishmaniasis in Peru using the TLR7 agonist imiquimod in combination with pentavalent antimony.

    Directory of Open Access Journals (Sweden)

    Cesar Miranda-Verastegui

    2009-07-01

    Full Text Available Current therapies for cutaneous leishmaniasis are limited by poor efficacy, long-term course of treatment, and the development of resistance. We evaluated if pentavalent antimony (an anti-parasitic drug combined with imiquimod (an immunomodulator was more effective than pentavalent antimony alone in patients who had not previously been treated.A randomized double-blind clinical trial involving 80 cutaneous leishmaniasis patients was conducted in Peru. The study subjects were recruited in Lima and Cusco (20 experimental and 20 control subjects at each site. Experimental arm: Standard dose of pentavalent antimony plus 5% imiquimod cream applied to each lesion three times per week for 20 days. Control arm: Standard dose of pentavalent antimony plus placebo (vehicle cream applied as above. The primary outcome was cure defined as complete re-epithelization with no inflammation assessed during the 12 months post-treatment period.Of the 80 subjects enrolled, 75 completed the study. The overall cure rate at the 12-month follow-up for the intention-to-treat analysis was 75% (30/40 in the experimental arm and 58% (23/40 in the control arm (p = 0.098. Subgroup analyses suggested that combination treatment benefits were most often observed at the Cusco site, where L. braziliensis is the prevalent species. Over the study period, only one adverse event (rash was recorded, in the experimental arm.The combination treatment of imiquimod plus pentavalent antimony performed better than placebo plus pentavalent antimony, but the difference was not statistically significant.Clinical Trials.gov NCT00257530.

  2. Activation of human CD141+ and CD1c+ dendritic cells in vivo with combined TLR3 and TLR7/8 ligation.

    Science.gov (United States)

    Pearson, Frances E; Chang, Karshing; Minoda, Yoshihito; Rojas, Ingrid M Leal; Haigh, Oscar L; Daraj, Ghazal; Tullett, Kirsteen M; Radford, Kristen J

    2018-04-01

    Mice reconstituted with human hematopoietic stem cells are valuable models to study aspects of the human immune system in vivo. We describe a humanized mouse model (hu mice) in which fully functional human CD141 + and CD1c + myeloid and CD123 + plasmacytoid dendritic cells (DC) develop from human cord blood CD34 + cells in immunodeficient mice. CD141 + DC are the human equivalents of murine CD8 + /CD103 + DC which are essential for the induction of tumor-inhibitory cytotoxic T lymphocyte responses, making them attractive targets to exploit for the development of new cancer immunotherapies. We used CD34 + -engrafted NSG-A2 mice to investigate activation of DC subsets by synthetic dsRNA or ssRNA analogs polyinosinic-polycytidylic acid/poly I:C and Resiquimod/R848, agonists for TLR3 and TLR8, respectively, both of which are expressed by CD141 + DC. Injection of hu mice with these agonists resulted in upregulation of costimulatory molecules CD80, CD83 and CD86 by CD141 + and CD1c + DC alike, and their combination further enhanced expression of these molecules by both subsets. When combined, poly I:C and R848 enhanced serum levels of key cytokines associated with cross-presentation and the induction of cytotoxic T lymphocyte responses including IFN-α, IFN-β, IL-12 and CXCL10. These data advocate a combination of poly I:C and R848 TLR agonists as means of activating human DC for immunotherapy. © 2018 Australasian Society for Immunology Inc.

  3. Apoptose e expressão de VP2 e GAPDH na infecção precoce pelo vírus da doença infecciosa da bursa de Fabricius em pintos SPF Apoptosis and expression of VP2 and GADPH in an experimental infectious bursal disease in SPF chicks

    Directory of Open Access Journals (Sweden)

    J.J. Batista

    2007-04-01

    Full Text Available Vinte e nove pintos SPF de um dia foram inoculados com o vírus da doença infecciosa da bursa de Fabricius (VDIB para avaliar a ocorrência precoce de apoptose e a expressão da proteína viral 2 (VP2 e da enzima gliceraldeído fosfato dehidrogenase (GAPDH. Os animais foram distribuídos em cinco grupos: 1-controle; e 2 a 5- com 24, 48, 72 e 96 horas pós-inoculação, respectivamente. Fragmentos da bursa de Fabricius foram colhidos para processamento histológico e extração de RNA. Lâminas coradas em HE e TUNEL (marcação in situ da fragmentação do genoma com transferase terminal de deoxinucleotídeo foram utilizadas na morfometria do índice apoptótico. Amostras de mRNA foram testadas para a expressão dos genes VP2 e GAPDH utilizando-se transcrição reversa e RT-PCR. Utilizou-se um kit SYBR GREEN PCR, e a reação foi desenvolvida em ABI Prism 7000 SDS. Os índices apoptóticos cresceram progressivamente indicando uma relação na atrofia bursal causada pelo VDIB. Paralelamente, os resultados da PCR em tempo real demonstraram queda da carga viral nas células linfóides da bursa nos diferentes intervalos de tempo do experimento. Esses resultados sugerem um papel protetor da apoptose na diminuição da replicação viral.Twenty-nine SPF 1-day-old chicks were inoculated with infectious bursal disease virus (IBDV to evaluate early apoptosis and the expression of viral protein 2 (VP2 and glyceraldehyde-3-phosphate dehydrogenease (GAPDH. Five groups were formed: G1-control -and G2 to G5, - 24, 48, 72 and 96 hours post inoculation, respectively. Half of each BF was fixed and processed by routine techniques. To quantify apoptosis, 5µm-thick sections were stained with HE and submitted to TUNEL (terminal transferase UDP nick end labeling technique. mRNA was extracted from pooled samples of 3 animals/group and used for the expression of VP2 and GADPH genes using the reverse transcription and real-time polymerase chain reaction (RT-PCR. A SYBR

  4. Analisis Pengaruh Indeks Bursa Saham Asing Dan Kurs Dolar Amerika Serikat Terhadap Indeks Bursa Efek Indonesia

    OpenAIRE

    Siregar, Adlin Syahputra Angkasa

    2011-01-01

    Examining the development of the Indonesia Stock Exchange is an interesting and challenging since the government removed the foreign ownership limit on the Indonesia Stock Exchange September 1997. In relative terms, the amount of factors influence the foreign stock market indices of the development of a stock shows the stock level of integration with world capital markets. Stock markets are more integrated with world capital markets, which are more influenced by foreign factors, the potential...

  5. Rasio Utang Memediasi Pengaruh Kemampulabaan Dan Ukuran Aktiva Terhadap Kebijakan Dividen: Studi Empiris Pada Perusahaan Perkebunan Kelapa Sawit Yang Terdaftar Di Bursa Efek Indonesia [Debt Ratio to Mediate Effect of Profitability and Asset Size on Dividend Policy: An Empirical Study on Oil Palm Plantation Companies Listed with the Indonesia Stock Exchange

    Directory of Open Access Journals (Sweden)

    Rudolf Lumbantobing

    2017-06-01

    Full Text Available This research explores the influence of the debt policy, profitability, and size of asset toward company's dividend policy on oil palm plantation companies listed with the Indonesia Stock Exchange for the years 2011-2015. The secondary data used in this research were obtained directly from the company website and the Indonesia Stock Exchange (IDX. The data collection was conducted by direct observation upon the research object. The data were analyzed using path analysis and logistical regression model. The result showed that profitability has a significant and negative effect on the debt ratio. Size of asset does not have a significant and positive effect on the debt ratio. Profitability and size of assets have significant and positive effects on dividend policy, which proves that the larger profitability and the size of assets, the greater the probabilty of paying dividends. Debt ratio does not have a significant and positive effect on dividend policy. Debt ratio has a significant positively partial mediating effect toward the influence of profitability on dividend policy. Otherwise, debt ratio does not have a significant negatively mediating effect toward the positive effect of size of asset on dividend policy.  BAHASA INDONESIA ABSTRAK: Penelitian ini mengeksplorasi engaruh kebijakan utang, kemampulabaan dan ukuran aktiva terhadap kebijakan dividen perusahaan perkebunan kelapa sawit yang terdaftar di Bursa Efek Indonesia periode tahun 2011-2015. Data yang digunakan adalah data sekunder yang diperoleh secara langsung dari website perusahaan dan Bursa Efek Indonesia. Pengumpulan data dilakukan dengan observasi tidak langsung terhadap objek penelitian yaitu perusahaan kelapa sawit. Data dianalisis dengan menggunakan path analysis dan model regresi logistik. Temuan penelitian ini menunjukkan bukti bahwa kemampulabaan signifikan berpengaruh negatif terhadap rasio utang. Ukuran aktiva tidak signifikan berpengaruh positif terhadap rasio

  6. Prediksi Financial Distress Pada Perusahaan Manufaktur Di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Randy Kurnia Permana

    2017-06-01

    Full Text Available Financial Distress Prediction in Manufacturing Companies at Indonesian Stock ExchangeThis study aims to identify, analyze, demonstrate and test the differences in health status between the model results Grover, Springate, and Zmijewski. The model used by investors who will invest in the company. This study has a characteristic that is tested three models and find the one best model. Data was tested using chi-square test. Results showed Hypothesis 1 accepted that there are differences in health status in the test model of Grover, Springate, and Zmijewski on manufacturing companies listed on the Stock Exchange 2006-2015. Model Springate is the best predictive model than the model Grover and Springate, because it has more components than the other models and models Springate have EBIT  To Current Liabilities component is how much profit the ability to pay debts. This component is a very important component to see financial distress, due to financial distress occur because one debt that not covered by the companyDOI: 10.15408/ess.v7i2.4797

  7. Bond Ratings dan Antesedennya: Studi Empiris di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Wendy Wendy

    2017-01-01

    Full Text Available This paper provides the empirical evidence of corporate growth, maturity, and operating cash flows on the bond ratings. It was conducted on 34 bonds issued by the 16 non-financial companies on the Indonesia Stock Exchange (IDX which also issued bonds, registered in the Indonesia Bond Market Directory, and rated by PEFINDO during 2012 - 2014. The hypotheses were tested using the logistic regression analysis. The result shows that corporate growth has significant effect on the bond ratings, while maturity and operating cash flow have no significant effect. Another finding shows that the firm size can also affect the bond ratings.

  8. Performance of Syariah and Composite Indices: Evidence from Bursa Malaysia

    OpenAIRE

    Mohamed Albaity; Rubi Ahmad

    2008-01-01

    This study provides new evidence on the risk and return performance of the Kuala Lumpur Syariah Index (KLSI) and the Kuala Lumpur Composite Index (KLCI). An Islamic stock market index such as KLSI selects stocks according to Islamic laws, and thus has a more stringent screening process than its conventional counterpart, KLCI. Our results, however, provide no evidence of significant statistical differences in risk-adjusted returns between Islamic and conventional stock market indices during 19...

  9. ANALISIS KONTRAK BERJANGKA OLEIN DI BURSA BERJANGKA JAKARTA

    Directory of Open Access Journals (Sweden)

    Andam Dewi

    2011-09-01

    Full Text Available Normal 0 false false false MicrosoftInternetExplorer4 st1\\:*{behavior:url(#ieooui } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Study about efficient market hypothesis is a common object for many financial researchers. Nevertheless, there are still limited studies about futures contract market particularly in the emerging market. The purposes of this study were to test the weak form efficiency of the Olein futures contract in the Jakarta Futures Exchange and to seek factors that can affect the fluctuation of Olein futures contract price. ARIMA and GARCH models were used as the basis for the analyses. Results of the study indicated that using weekly data, the weak form efficient market (random walk hypothesis was rejected for the Olein futures contract in the Jakarta Futures Exchange, meaning that the market was in efficient.This implies that some one will be able to outperform the market using technical analysis for predicting future price changes. Furthermore, using monthly data, the fluctuation of Olein futures contract returnis influenced significantly by interest rate, exchange rate and CPO price.   Keywords : Jakarta Futures Exchange, Efficient Market Hypothesis, ARIMA, GARCH

  10. Serological Detection of Infectious Bursa Disease Virus Antibodies ...

    African Journals Online (AJOL)

    (AGPT). The results showed that local chickens had the highest distribution with 446 ... that the chickens are more at risk, susceptible and have higher potential of being infected by ..... In many homes the local birds are ... sample collection.

  11. Candlestick Charting and Trading Volume: Evidence from Bursa Malaysia

    OpenAIRE

    Chin, Chee-Ling; Jais, Mohamad; Balia, Sophee Sulong; Ahmad, Ayoib Che; Abidin, Azlan Zainol

    2016-01-01

    Technical analysis is deemed to be a futile practice among academicians who propose efficient market hypothesis, typically the weak form market efficiency which strongly protests the application of past prices and trading volume data for prediction of future market movement. As candlestick charting is one of the oldest technical indicators for short term investment, therefore this study examines the predictability of candlestick charting with combination to trading volume for Malaysian stock ...

  12. EXECUTIVE STOCK OPTION EXERCISING BEHAVIOR: EVIDENCE FROM BURSA MALAYSIA

    OpenAIRE

    Ahmad Ibn Ibrahimy; Dr. Rubi Ahmad

    2012-01-01

    In spite of the fact that shareholders exercise their options when it is in the money, s eparation of ownership and control creates the necessity of verifying the adoption of corporate governance mechanism, such as Executive Stock Option Scheme (ESOs). This study verifies the relationship between Executive Stock Option (ESO) exercise and firm performance to explore the exercise pattern of Malaysian executives whether there is any differences in trading option. We found a significant positive ...

  13. Sağlık politikaları ile meslek ahlakı arasında ilişki var mı? Bursa Tabip Odası’na yapılan başvurular örneğinde bir değerlendirme

    Directory of Open Access Journals (Sweden)

    Kayıhan Pala

    2016-12-01

    Full Text Available Amaç:Hekimlik pratiğine dair meslek örgütüne yansıyan ihlal iddialarını ve belirleyenlerini incelemektir. Yöntem:Araştırma, Bursa Tabip Odası (BTO Yönetim Kurulu’nun 1991-2014 yılları arasındaki tüm kayıtlarının, Onur Kurulu dosyalarının ve bilgisayar kayıtlarının taranmasıyla gerçekleştirilmiştir.Bulgular:İncelenen dönemde BTO’ya yapılan 593 başvuruda toplam 623 ihlal iddiası bulunmaktadır. İhlal iddialarının %46.2’si Onur Kurulu’na iletilmiş ve %29.5’ine yaptırım uygulanmasına karar verilmiştir. Başvurular en çok hasta, hasta yakını ya da hastanın vekili tarafından yapılmıştır (%34.1. Hakkında başvuru yapılan hekimlerin %75.7’si uzman,  %23.3’ü pratisyen, %1.0’i asistan hekimdir. En sık üç ihlal iddiası sırasıyla; tanıtım kurallarının ihlali, haksız kazanç/rekabete aykırılık (%24.8, tıbbi uygulama hatası (%21.4 ve gerçek dışı belge/rapor düzenlemektir (%18.2. ‘Gerçek dışı belge/rapor düzenlemek’, ‘Hasta haklarına saygısızlık’ ve ‘Aracılık, yönlendirme, çıkar ilişkisi’ eylemlerinin Sağlıkta Dönüşüm Programı (SDP sonrasında anlamlı derecede arttığı saptanmıştır. Zorunlu Mesleki Sorumluluk Sigortası sonrasında tıbbi uygulama hatası iddialarının sayısında ve bu iddia sonucunda yaptırıma uğratılan hekim sayısında anlamlı bir artış saptanmamıştır. Sonuç:Bu çalışma ile hekimlik uygulamalarına dair meslek ahlakı ihlallerini anlayabilmek ve sorunları saptayabilmek açısından önemli çıkarımlar elde edilmiş, bulgular SDP ile uygulamaya konulan politikaların mesleki yükümlülüklerin yaşama geçirilmesini güçleştirebileceği yönünde yorumlanmıştır.Anahtar kelimeler:Hekim, meslek ahlakı, etik, tabip odası, onur kurulu

  14. P-16: Takım Sporu Yapan Bireylerde Görülen Sakatlık Türleri ve Bu Sakatlıkların Çeşitli Değişkenlere Göre İncelenmesi (Bursa Örneği

    Directory of Open Access Journals (Sweden)

    İlker Kirişci

    2017-03-01

    Full Text Available u araştırma; Voleybol, basketbol, futbol, hentbol branşlarında 16 – 28 yaş aralığındaki erkek sporcuların sakatlıklarla ilgili bilgi düzeylerini tespit etmek ve branşlar arasındaki farklılıkları ortaya çıkarmak amacıyla yapılmıştır.Araştırma kapsamındaki ankette Bursa il sınırlarında voleybol, basketbol, futbol, hentbol branşlarındaki lisanslı erkek sporcuların karşılaştıkları sakatlıkların ve sakatlıklardan korunma konusundaki bilgi düzeylerinin, bu parametrelerin branşlara göre farklılıkları ortaya konulmuştur. Uygulama, çalışmanın uygulandığı süre içerisinde ulaşılan toplam 250 sporcu üzerinde yapılmıştır. Yaş ortalaması 19,2±2,79 olarak hesaplanmıştır. Verilerin analizi bilgisayarda SPSS 16.0 programı kullanılarak gerçekleştirilmiştir. Sürekli değişkenlerin karşılaştırılmasında T testi ve ANOVA kullanılmıştır. Kategorik veriler ise çapraz tablolar, ki kare testi ve Pearson Korelasyon Testi kullanılarak analiz edilmiştir.Yapılan çalışmada kas sakatlıkları, bağ ve menisküs sakatlıkları ve burkulma olayları daha sık görülmektedir. Sakatlıkları en az önemseyenler basketbolcular, daha çok önemseyenler ise voleybolcular olmuştur. Büyük bölümü sakatlanmaya karşı özel bir önlem almaya gerek duymamışlardır. 250 sporcunun 216’sı en az 1 kez sakatlanmış ve 156’sı futbolu daha riskli görmektedir. Futbol, basketbol ve hentbolda en çok rakibin darbesiyle sakatlanma yaşanmakta, voleybolda ise yetersiz ısınma sakatlığa neden olmaktadır. Sporcuların çoğu sakatlıklar karşısında doktora gitmeyi tercih etmektedir. Yarısından fazlası ise (%53,2 sağlık kontrolünden geçmemişler ve sakatlıklar en çok kullanılan uzuvlar üzerinde oluşmaktadır. Futbolda alt ekstremite sakatlıkları çok beklenirken üst ekstremite sakatlıkları daha sık görülmüştür. Bunun sebebi; düşme tekniğini yanlış uygulama

  15. Pengaruh Intellectual Capital Terhadap Produktivitas, Profitabilitas, Nilai Pasar Pada Perusahaan Manufaktur Di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Eva Wany

    2010-10-01

    Full Text Available The research to testing and analysis the influence of intellectual capital to productivity, profitability, market value, to testing and analysis the influence of intellectual capital to market value with productivity as intervening variable, to testing and analysis the influence of intellectual capital to market value with profitability as intervening variable of manufacture company listed in Indonesia Stock Exchange. The sample of this study consists of 48 financial company listed in Indonesia Stock Exchange in period 2005-2007. The research data is analysis by using descriptive technique and tested by using using multiple regression analysis. Result of test of simple linier regression model proves that intellectual capital influence does not productivity, intellectual capital influence to profitability, intellectual capital influence to market value, intellectual capital influence to market value with productivity as intervening variable but direct influence productivity don't overweening influence to market value, intellectual capital influence to market value with profitability as intervening variable and direct influence profitability to market value statistically proven signifikan.

  16. ANALISIS KOMPONEN REVERSE MEAN PADA HARGA SAHAM MELALUI PERSPEKTIF EKONOMI MAKRO DI BURSA EFEK JAKARTA

    Directory of Open Access Journals (Sweden)

    Aster Indah Widowati

    2012-05-01

    Full Text Available ABSTRACTSReverse mean reversion and predictability of stock return is probably the most well researched topic in the empirical research of financial economics. Numerous empirical studies have been unable to reject the hypothesis that return unpredictable and that stock price follows a random walk or martingale process. The essence of the mean-reversion hypothesis is that the stocks price contains a temporary component. Thus, the market value of stock deviates from the fundamental value but will revert to its mean. The objective of this study is to test the mean reversion hypothesis in Indonesian capital market, by investigate the size and significance of mean reversion component of stock prices at the Jakarta Stock Exchange, for the period of January 1990 through December 2003, and to investigate the size of the forecast error variance decomposition for real stock prices which is caused by permanent innovation and temporary innovation for a horizon of 2, 3, 4, 6, 12 and 24 months. By placing appropriate structural restrictions on a vector auto-regressive system estimated for the period of January 1990 through December 2003, it was found that the temporary component in the stock prices at the Jakarta Stock Exchange has significant size. From this, it can be inferred that the pattern of share price movements at the Jakarta Stock Exchange has a temporary component which will gradually disperse or undergo reverse mean. This evidence supports the mean reversion hypothesis that stock price are not pure random walks and predictability of stock return and reject the random walk hypothesis. Keywords: Reverse mean component, Macroeconomic Perspective

  17. PENGARUH STRUKTUR KEPEMILIKAN TERHADAP KEMUNGKINAN KESULITAN KEUANGAN PADA BURSA EFEK INDONESIA

    OpenAIRE

    Indra Hastuti

    2015-01-01

    Financial distresses have strong relationships with the company’s bankruptcy. The financial distress can be predicted by using information contained in the financial statements and the company’s corporate governance mechanisms. The purpose of this study is to prove the effect of ownership structure, liquidity ratios, leverage ratios, activity ratios, and the size of the company to possible financial distress of manufacturing companies in Indonesia Stock Exchange. Populations of this study are ma...

  18. REAKSI PASAR ATAS PENGUMUMAN CORPORATE GORVERNANCE PERCEPTION INDEX (Studi Peristiwa di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    I GDE ARY WIRAJAYA

    2011-01-01

    Full Text Available Corporate governance perception index (CGPI is a research project ongrading good corporate governance in Indonesia. This program is expected topositively influenced investors’ confidence to invest. This research examinesmarket reaction by detecting market reaction differences between high-rankand low-rank companies around the date of CGPI announcement in 2006 –2008 through seven days of observation.This research was conducted in Indonesia Stock Exchange. Sampleconsisted of 52 companies which were drawn using purposive samplingmethod. Data were analyzed using descriptive, statistic, and sensitivityanalysis. Result showed that market reacted to CGPI announcement, whichwas demonstrated by abnormal return and changes of stock traded volumearound the date of CGPI announcement. There was no significant differenceabout market reaction between high and low rank companies on CGPI during2006 – 2008. This implies that investors have not considered CGPI properly instock market transactions.

  19. PENGARUH LIKUIDITAS MODAL KERJA TERHADAP PROFITABILITAS PERUSAHAAN SEKTOR PERUNGGASAN YANG TERDAFTAR DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Cosmas A.I. Wardojo

    2016-11-01

    Full Text Available Working capital management is one of the most frequently discussed topics in researches, for companies attempt to obtain liquidity and operational efficiency in managing their working capital. Hence, this study aimed to analyze the company profitability and capital policy influences performed by the poultry sector company towards company profitability in the same period. The method in the study was a panel regression by adopting Ordinary Least Square estimation method and by using fixed effects in reference to Chow test results. Classic assumption test and Goodness of Fit Tests were also conducted to examine the selected models. The results showed that the components of cash conversion cycle and net trade cycle have significant positive effects on profitability, enabling the industry to increase profits by effectively managing each part of net working capital.Keywords: cash conversion cycle, net working capital, net trade cycle, profitability, working capital management, ordinary least squareABSTRAKManajemen modal kerja merupakan topik yang paling sering didiskusikan dalam penelitian, perusahaan berusaha mendapatkan likuiditas dan efisiensi operasional dalam mengelola modal kerja mereka. Penelitian ini bertujuan menganalisis profitabilitas perusahaan dan  pengaruh kebijakan modal kerja yang dilakukan oleh perusahaan disektor perunggasan terhadap profitabilitas perusahaan dalam kurun waktu yang sama. Metode  yang digunakan adalah regresi panel dengan metode pendugaan Ordinary Least Square menggunakan efek tetap berdasarkan hasil uji Chow. Uji asumsi klasik dan Goodness of Fit Uji juga telah dilakukan untuk menguji model yang terpilih. Hasil penelitian menunjukkan bahwa konversi kas komponen siklus dan siklus perdagangan bersih berpengaruh positif signifikan terhadap profitabilitas, sehingga industri dapat meningkatkan keuntungan dengan mengelola secara efektif setiap bagian dari modal kerja bersih.Kata kunci: siklus konversi kas, modal kerja bersih, net trade cycle, profitabilitas, pengelolaan modal kerja, ordinary least square.

  20. Probabilitas Tingkat Laba Bursa Efek Indonesia Periode 1 Juli 1997 – 1 Juli 2011

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    Tomy G. Soemapradja

    2011-11-01

    Full Text Available Capital market investor should considers whether the higher expected return, the more risk should be taken, to minimize speculative decision. The research objectives are measuring and describes the probability distribution of market return of IHSG, in July 1, 1997- July 1, 2011, according to availability of public data provided by Indonesian Stock Exchange (IDX. Classification were made with several considered assumptions, results that the largest probability movements of Indonesian Stock Exchange, represented by IHSG percentage of change, is relatively stable of 89,1%, the cumulative probability of downtrend and market crash is 6.3%, whether the cumulative probability of uptrend and booming is 4,6%. This research results the expected return based on probability distribution is 0.049% per day. Assumed 12% pa of time deposits interest rate or 0.033% per day, it means the market risk premium only 0.17% per day or 6% pa. The Capital market is suitable for risk seeker rather than risk averter or risk normal. But risk averter and risk normal may use other alternative instrument such mutual funds when they want to invest their money into capital market. 

  1. Pengaruh Dividend Initiations dan Dividend Cut/Omissions terhadap Return Saham di Bursa Efek Jakarta

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    Sri Dwi Ari Ambarwati

    2009-08-01

    Full Text Available This research investigates market reactions to initiations and cut/omissions of cash dividend payment. Consistent with prior literature, the result of this research tend to support the propositions that shareholders make considerable use of the information implicit in dividend announcement. Shareholders react positively significant to the dividend initiations announcement and negatively significant to the dividend cut/omissions announcement. A multiple regression model is formulated to identify the factors that contribute significantly to the capital gain (loss suffered by shareholders when firm decide to initiate (cut/omit dividend. Result indicate that, in conformity with the information content hypothesis, the shareholders’s respond to dividend initiations significantly depends on  the firm size and the cumulative return movement (CARM in the preceding period. Whereas, the shareholders’s re¬spond to dividend cut/omissions significantly depends on the cumulative return movement (CARM in the preced¬ing period and risk/corrected beta of the firm at alpha 1% and 5%.Keywords: Signaling hypothesis, Dividend initiations, dividend cut/omissions

  2. A review on Black-Scholes model in pricing warrants in Bursa Malaysia

    Science.gov (United States)

    Gunawan, Nur Izzaty Ilmiah Indra; Ibrahim, Siti Nur Iqmal; Rahim, Norhuda Abdul

    2017-01-01

    This paper studies the accuracy of the Black-Scholes (BS) model and the dilution-adjusted Black-Scholes (DABS) model to pricing some warrants traded in the Malaysian market. Mean Absolute Error (MAE) and Mean Absolute Percentage Error (MAPE) are used to compare the two models. Results show that the DABS model is more accurate than the BS model for the selected data.

  3. Analisis Pengaruh Publikasi Laporan Keuangan Interim Terhadap Abnormal Return Saham Di Bursa Efek Indonesia (Bei)

    OpenAIRE

    jatiningrum, citrawati

    2009-01-01

    Target of financial statement is provide the information which is concerning financial position of an worthwhile company to a large amount of user in economic decision. Interim financial statement represent the financial statement published among annual financial statement, able to be compiled in monthly, quarterly or other period is which less than one year including entire all financial statement component.This research is aim to prove empirically whether what there is influence which signi...

  4. VALUE RELEVANCE DAN IFRS ADOPTION DI INDONESIA: INVESTIGASI PADA PERUSAHAAN LQ-45 BURSA EFEK INDONESIA

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    Triandi ,

    2017-02-01

    Full Text Available Value relevance is being defined as the ability of information disclosed by financial statements to capture and summarize firm value. earnings per share (EPS and book value of shares (BVS and stock market price (SMP, both before and after IFRS adoption. Based on theresult,test there the valuerelevancebefore and after IFRS adoptio. The value relevance after IFRS adoption decreased. These findings differ from the findings in several countries have adopted IFRS. In many countries have adopted IFRS tends to increase the value relevance. Keyword : value relevance, earning per share, book value of equity, stock price, IFRS adoption, LQ-45

  5. PERBANDINGAN MODEL OPSI BLACKSCHOLES DAN MODEL OPSI GARCH DI BURSA EFEK INDONESIA

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    Riko Hendrawan

    2017-03-01

    Full Text Available The purpose of this research was to compare the accuracy of Black-Scholes Opt ionModel and GARCH opt ion models for Stock opt ion ut ilizing data f rom Ast ra, BCA, Indofoodand Telkom at the Indonesian Stock Exchange. The intraday stock return of Astra, BCA, Indofoodand Telkom exhibited an overwhelming presence of volat ilit y cluster, suggesting that GARCHmodel had an ef fect which best corresponded with the actual price. The best model wasconst ructed using ARIMA model and the best lag in GARCH model was ext racted. The findingf rom this research showed that by comparing the average percentage mean squared errors ofthe GARCH Opt ion Model and the Black-Scholes Opt ion Model, the former was found moreaccurate than the lat ter. GARCH Model relat ively improved average percentage mean squarederrors of Black-Scholes Model; one month opt ion showed a twent y eight point ten percentimprovement , two month option showed twenty three point thirt y percent and three monthopt ion showed twent y percent .

  6. PENDEKATAN MODEL PENILAIAN DALAM PENGAMBILAN KEPUTUSAN INVESTASI SAHAM DI BURSA EFEK INDONESIA

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    Sri Isworo Ediningsih

    2017-03-01

    Full Text Available A valuation model was a mechanism that converted a set of forecast, a series of company and economic variablesinto a forecast of market value for the company’s stock. The purpose of this study was to examine relevance amongdividend yield, retained earnings, book value and total debt on stock price: approximation valuation model in theIndonesia Stock Exchange. Samples in this study were manufacture firms listed on the Indonesia Stock Exchangeperiod 2008–2011 and divided dividend. The results showed that few of samples were undervalue and the otherswere overvalue. It meant valuation model could be applicated in the Indonesian stock exchange. By using multipleregressions, this study found that: valuation model relevans used in investment decission in manufacturefirms in the Indonesia Stock Exchange could prove simultaneously dividend yield, retained earnings, book valueand total debt had significant effect to stock price and partially dividend yield had no significant effect to stockprice and whereas retained earnings, book value and total debt had significant effect in partial to stock price.

  7. STRATEGI VALUATION MODEL: PENGAMBILAN KEPUTUSAN INVESTASI PADA PERUSAHAAN MANUFAKTUR DI BURSA EFEK INDONESIA

    OpenAIRE

    Hasa Nurrohim KP; Sri Dwi Ari Ambarwati

    2017-01-01

    This research was based upon Riahi-Belkaoui & Picur (2001) and Richard G Baker(1999) result which supposed there was relation between IOS with dividend and retained earningpolicy. Purpose of this research was to know empirically impact of valuation model strategy toinvestment decision making on manufacturing company. Using data of manufacturing companieswas listed during 2000-2005 in Indonesia Stock Exchange and analyzed with multiple regression.The results found were: 1). There was no ef...

  8. STRATEGI VALUATION MODEL: PENGAMBILAN KEPUTUSAN INVESTASI PADA PERUSAHAAN MANUFAKTUR DI BURSA EFEK INDONESIA

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    Hasa Nurrohim KP

    2017-03-01

    Full Text Available This research was based upon Riahi-Belkaoui & Picur (2001 and Richard G Baker(1999 result which supposed there was relation between IOS with dividend and retained earningpolicy. Purpose of this research was to know empirically impact of valuation model strategy toinvestment decision making on manufacturing company. Using data of manufacturing companieswas listed during 2000-2005 in Indonesia Stock Exchange and analyzed with multiple regression.The results found were: 1. There was no effect between stock price with dividend on companiesand High IOS (Investment Opportunity Sets although Low IOS. 2. There was significantlypositive effect between stock price with retained earning on companies and High IOS (InvestmentOpportunity Sets.

  9. ANALISIS FUNDAMENTAL MAKRO DAN INTEGRASI PASAR SAHAM DUNIA DENGAN BURSA EFEK INDONESIA

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    Luh Gede Sri Artini

    2017-11-01

    Full Text Available Penelitian ini merupakan gabungan dari penelitian sebelumnya mengenai hubungan antara harga saham dengan kinerja ekonomi makro, dan penelitian mengenai integrasi Pasar Modal internasional.Variabel ekonomi makro dalam penelitian ini dibatasi pada pertumbuhan PDB, tingkat suku bunga SBI dan nilai Kurs dolar Amerika terhadap Rupiah dan Indeks saham digunakan adalah Indeks Dow Jones, Indeks Saham Australia, Indeks Shanghai dan Indeks Singapura. Data dikumpulkan dari tahun 2011 sampai tahun 2015 secara bulanan dengan teknik analisis regresi linier dengan bantuan Statistical Package For Social Science (SPSS

  10. PERENCANAAN PENYALURAN TENAGA KERJA OLEH BURSA KERJA KHUSUS (BKK SMK MIGAS CEPU

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    Aldila Prajamudi Karaning Utami

    2014-11-01

    Full Text Available Metode penelitiaan yang digunakan adalah kualitatif. Teknik pengumpulan data yang digunakan observasi, wawancara dan dokumentasi. Teknik analisis data menggunakan teknik deskriptif kualitatif. Hasil penelitian pada pertanyaan pertama yaitu proses identifikasi lowongan pekerjaan, dalam proses identifikasi tersebut terdapat beberapa perusahaan mitra BKK meliputi bidang teknik dan industri, jasa dan niaga. Kemudian fasilitas-fasilitas pelayanan yang disediakan BKK terdiri dari: (1 Pusat Informasi Lowongan Pekerjan, (2 Blog/Web Khusus Alumni SMK MIGAS, (3 Brosur Lowongan Pekerjaan, (4 Bimbingan Karir dan Analisis Jabatan. Sedangkan teknik atau/metode yang digunakan dalam pemasaran lulusan meliputi beberapa segi, diantaranya yaitu: (1 Segi pengelolaan BKK, (2 Segi pengelolaan calon alumni, (3 Segi pengelolaan DU/DI, (4 Segi pengelolaan kemitraan. Terakhir adalah prosedur/tahapan dalam penyaluran dan penempatan tenaga kerja, dilihat dari prosesnya BKK terdiri dari 3 kegiatan inti yaitu (1 pemetaan (alumni/lulusan dan DU/DI, (2 penyaluran alumni/lulusan, dan (3 jalinan kerjasama dengan pihak DU/DI. Berdasarkan hasil penelitian di atas, dapat disimpulkan bahwa ada bebrapa kegiatan BKK yang berkaitan dengan penyaluran tenaga kerja. Beberapa hal meliputi Proses identifikasi lowongan pekerjaan, Fasilitas-fasilitas pelayanan dalam rangka memberikan informasi tentang lowongan pekerjaan/dunia kerja, Teknik/metode BKK untuk memasarkan lulusannya, Prosedur/tahapan dalam penyaluran dan penempatan tenaga kerja merupakan hal-hal yang sangat mempengaruhi proses perencanaan penyaluran tenaga kerja. The results of research on the first question, namely the identification of a job, in the identification process, there are several companies BKK partners include engineering and industry, services and commerce. Then the service facilities provided by BKK consists of: (1 The job Job Information Center, (2 Blog / Alumni Special Web CMS Oil and Gas, (3 Brochure Jobs, (4 Career Guidance and Job Analysis. While the technique or / methods used in marketing graduates include several aspects, among which are: (1 the management aspect BKK, (2 the management aspect of prospective graduates, (3 the management aspect DU / DI, (4 facet of the management of the partnership. Last is the procedure / stages in the distribution and placement of workers, seen from BKK process consists of three core activities: (1 mapping (the alumni / graduates and DU / DI, (2 the distribution of the alumni / graduates, and (3 a system of alliances with the DU / DI. Based on the above results, it can be concluded that there is a miraculous BKK activities related to the distribution of labor. Some of the jobs include identification process, service facilities in order to provide information on jobs / employment, Engineering / BKK method for marketing graduates, procedures / stages in the distribution and employment are the things that influence the process of planning for the distribution labor.

  11. Kinerja Portofolio Saham pada Perusahaan Makanan, Property dan Pertambangan di Bursa Efek Indonesia

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    Nasri Zarman

    2017-06-01

    Full Text Available The Stock Portfolios' Performance of Food, Property, and Mining IndustryThis research aimed to analyze the Portfolio's performance of food industry, property, and mining. There are three parameters, namely: Sharpe Performance, Traynor Performance, and Jensen Performance. The three performance measurements assume that there is a linear connection between the return portfolios with the return of some market index. During the period, 2009 to 2013, and the mining and gas sub-sector are more productive than the other sub-sectors. The mining sector is better than the Property Sector and the Food Sector. Then based on the method of Jensen ALPHA it showed the highest performance group of mining stocks, in proportion to the risk which is also very high. The study suggests that the existing has to be maintained and further improved so that the mission to develop sources of potential energy into a profitable investment portfolio can sustain.DOI: 10.15408/ess.v7i2.5354

  12. PERAN INDIKATOR KEKAYAAN INTELEKTUAL TERHADAP KINERJA PERUSAHAAN PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Elen Puspitasari

    2015-04-01

    Full Text Available Capability of knowledge and technology becomes a key factor for the progress of the economy in many developed countries, so there is a necessity intended for companies to change their business strategy, which was originally based labor force towards knowledge-based businesses. Companies need to communicate some other information to users of financial statements related to the value added that is owned by the company i.e. intellectual capital (IC.This study will describe the role of IC indicators as measured by VAICTM, which consists of VACA, VAHU, and STVA to the company's performance measured by market valuation, profitability and productivity,which firm size as a control variable. The population in this study is manufacturing companies listed on the IDX from 2007 to 2010, with purposive sampling to obtain a sample of 20 companies with 80 data observations. The results of statistical hypothesis testing using multiple linear regression test showed that the IC has a positive and significant influence on company's performance. Kemampuan pengetahuan dan teknologi menjadi faktor kunci bagi kemajuan ekonomi di banyak negara maju, sehingga ada kebutuhan yang ditujukan bagi perusahaan untuk mengubah strategi bisnis mereka, yang pada awalnya berbasis tenaga kerja terhadap usaha berbasis pengetahuan. Perusahaan perlu berkomunikasi beberapa informasi lain untuk pengguna laporan keuangan yang berkaitan dengan nilai tambah yang dimiliki oleh perusahaan yaitu modal intelektual (IC. Penelitian ini akan menjelaskan peran IC indikator yang diukur dengan VAIC, yang terdiri dari VACA, VAHU, dan STVA untuk kinerja perusahaan yang diukur dengan nilai pasar, profitabilitas dan produktivitas, yang ukuran perusahaan sebagai variabel kontrol. Populasi dalam penelitian ini adalah perusahaan manufaktur yang terdaftar di BEI 2007-2010, dengan purposive sampling untuk mendapatkan sampel dari 20 perusahaan dengan 80 data pengamatan. Hasil pengujian hipotesis statistik menggunakan uji regresi linier berganda menunjukkan bahwa IC berpengaruh positif dan signifikan terhadap kinerja perusahaan.

  13. Spesialisasi Industri Auditor Sebagai Prediktor Earnings Response Coefficient Perusahaan Publik yang Terdaftar di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Hans Hananto Andreas

    2012-01-01

    Full Text Available This study investigates the effect of auditor’s industry specialisation on the ERC of public companies listed on the BEI in the period of 2006-2010. The purpose of this study is to examine the relationship between audit quality as proxied by auditor’s industry specialisation and the earnings information quality as measured by ERC. Hypothesis testing was conducted using multiple linear regression technique. Using purposive sampling technique, 134 public companies listed on the BEI were selected as the sample of this study. This study finds that there is a positive relationship between auditor’s industry specialisation and company’s ERC. The ERC of companies that use auditors with industry specialisation is higher than ERC of companies that do not use auditors with industry specialisation.

  14. KOREKSI BIAS BETA SAHAM DI BURSA EFEK INDONESIA PERIODE 2009-2012

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    Indah Saptorini

    2016-04-01

    Full Text Available This  study  aims  to  determine  whether  the  beta  value  of  shares  listed  on  the Indonesia Stock Exchange (BEI is a bias beta due to nonsynchronous trading activities.  There  are  310  companies  listed  on  the  Stock  Exchange  2009-2012 period  sampled  in  this  study.  The  bias  needs  to  be  corrected.  From  three methods employed : the Scholes and Williams (1977, the Dimson (1979, and the Fowler and Rorke (1983. Results of the analysis conclude that the shares on the Stock Exchange has a bias beta caused by not having a securities trading for  some  time.  This  resulted  in  the  calculation  of  IHSG  the  period  of  t  was biased because it uses the closing price of the period t-1.  In  this  study  bias  beta  correction  method  Scholes  and  Williams  (1977,  both one lag one lead and two lag two lead are better than the bias beta correction method Dimson (1979 and the bias beta correction method Fowler and Rorke (1983 because the value of beta Scholes and Williams after corrected close to one. Keywords : Nonsynchronous tradings, thin tradings, bias

  15. ANALISIS KINERJA SAHAM SEKTOR FARMASI PADA BURSA EFEK INDONESIA (BEI TAHUN 2012-2014.

    Directory of Open Access Journals (Sweden)

    Firman Hidayat

    2016-08-01

      Abstrak. Pasar Modal merupakan salah satu sarana untuk melakukan investasi, yaitu memungkinan para pemodal (investor untuk melakukan diversifikasi invetasi, membentuk portofolio sesuai dengan risiko yang bersedia mereka tanggung dan tingkat keuntungan yang mereka harapkan. Pasar modal adalah pertemuan antara yang memiliki kelebihan dana (pihak investor dengan pihak yang membutuhkan dana ( pihak perusahaan dengan cara memperjualbelikan sekuritas. Investasi dalam bentuk saham memiliki resiko yang sangat besar. Kesalahan dalam pemilihan saham yang akan dibeli dapat mengakibatkan kerugian yang fatal. Oleh karena itu, investor harus dapat memilih dengan baik saham yang dibelinya. Pemilihan ini dapat dilakukan dengan melihat kinerja perusahaan selama kurun waktu tertentu. Salah satu cara yang umum untuk menilai kinerja perusahaan adalah dengan cara mengukur kinerja keuangan perusahaan dengan menggunakan rasio keuangan. Rasio keuangan terdiri dari rasio likuiditas, rasio aktivitas, rasio solvabilitas dan rasio profitabilitas. Dalam hal ini penulis menggunakan Rasio Likuiditas yang diwakili oleh Current Ratio dan Rasio Profitabilitas yang diwakili oleh Earning Per Share dan Net Profit Margin.Berdasarkan hasil pengujian hipotesis dengan menggunakan analisis regresi berganda yang disertai dengan asumsi klasik menunjukkan bahwa Current Ratio (CR, Earning Per Share (EPS, Net Profit Margin (NPM berpengaruh signifikan    terhadap Return Saham. Hal ini dapat ditunjukkan dengan nilai probabilitas nya atau p-value yang mempunyai nilai < Kata Kunci: Current Ratio (CR; Earning Per Share (EPS;  Net Profit Margin (NPM;  Return Saham

  16. Relevansi Nilai Modal Intelektual Terhadap Nilai Pasar Perusahaan di Bursa Efek Indonesia

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    Akbar yusuf

    2015-08-01

    Full Text Available The purpose of this study was to test the direct and moderation relationship between intellectual capital and components with market value. This study analyzed secondary data available at the Indonesia Stock Exchange in 2008-2012, using multiple linier regression analysis techniques and moderation. Four factors are used to reduce bias control models of the Leverage (DEBT, Size, R&D expenditure, and Advertising expenditure. The result is intellectual capital and its components have the relevant value with market value. The presence of R&D expenditure increase its market value. Interaction human capital and structural capital provides relevant value to market value, but negatively.

  17. DETERMINAN STRUKTUR MODAL PADA SEKTOR KEUANGAN YANG LISTING DI BURSA EFEK INDONESIA

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    NI KETUT SUKASIH

    2011-07-01

    Full Text Available The purpose of this study is to investigate the influence of partial and simultaneous determinants of capital structure, including the cost of interest, dividend policy, size of the company, return on equity (ROE and return on investment (ROI and taxes paid in the financial sector. This research is limited to banking and lease corporation listing on the Indonesia Stock Exchange. Hypothesis is tested using multiple regression analysis and chow test. The results show that banking interest expense, dividend policy, company size, ROE, ROI and paid taxes simultaneously affect capital structure with adjusted R square value of 0.298 (29.8% which means that 29.8% of the variation in capital structure can be explained by the six independent variables, interest, dividend policy, company size, ROE, ROI and taxes while the remaining 70.2% is explained by other variables. Results of the lease obtain the adjusted R square of 0.353 (35.3% meaning that variation in capital structure can be explained by the six independent variables, while the remaining 64.7% is explained by other variables.

  18. PENGARUH LEVERAGE TERHADAP PROFITABILITAS PADA INDUSTRI MAKANAN DAN MINUMAN YANG TERDAFTAR DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Henny Setyo Lestari

    2009-03-01

    In this study, selected on food and beverage manufacturing subindustry listed on the Indonesia Stock Exchange during a periode of 11 years from 1999 — 2009. Using Kruskal Wallis testing, spearman correlation analysis and the classical assumption of normality. The result showed that the data DFL, DOL, and DCL didn't differ significantly in manufacturing subindustry. fry the DER and EPS data show that differ significantly in manufacturing subindustry of food and beverages. In addition these studies show that the DFL and DCL have a positive relationship to the EPS, while the DOL and the DER ha.s'a negative relationship to the EPS. Keywords : DCL, DER, DFL, DOL, Earning Per Share, Leverage, and Profitability

  19. Subdeltoid Bursa Tuberculosis with Rice Body Formation–A Case Report

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    Santosh L. Munde

    2015-01-01

    Full Text Available Tuberculous tenosynovitis and bursitis account for approximately 1%. A 56 years old female presented with swelling in left shoulder, gradually increasing in size with slight restriction in movement since last three months. X-ray revealed no abnormality of humerus head. Histopathological examination showed granulomatous tissue with multiple rice bodies. A positive culture of mycobacterium tuberculosis confirmed the diagnosis of tuberculosis. We here report a case of subdeltoid bursitis with rice body formation and without active bone and joint tuberculosis.

  20. Merger Auditor dan Kualitas Audit: Bukti Empiris Dari Bursa Efek Indonesia

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    Sansaloni Butar-Butar

    2016-06-01

    Full Text Available Merge rof Pricewaterhouse and Coopers & Lybrands that occurred in 1998 creates PricewaterhouseCoopers as the biggest accounting firm in history. Conceptually and supported by previous empirical result firm size is expected to be positively correlated with audit quality. Large accounting firms have financial ability to improve its auditors skill and can act more independently because major part of their income do not come from one or two clients. They spend huge investment in audit technology as well. However, this positive relationship only applies to environments where punishment is strictly imposed on audit failure. Unlike their counterparts in the United States and Europe, auditors working in Indonesia rarely face legal issues related to the audit assignment. In addition, empirical studies in Indonesia have always classified local auditors as Big N auditors if they affiliate with one of Big N auditors assuming same quality with that of Big N auditors. This assumption does not necessarily hold. Therefore, in the context of Indonesia environtments, this study predicts PricewaterhouseCoopers merger does not affect the quality of the audit. Using abnormal accruals as a proxy for audit quality, the results show that after the merger audit quality has declined significantly.

  1. PENGARUH BULAN RAMADHAN TERHADAP RETURN PASAR SAHAM DI BURSA EFEK INDONESIA (1425H-1434H

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    Aprida Rusmayanti

    2016-06-01

    Full Text Available The phenomenon of monthly effect is when the desire of financiers on the liquidity of stock changes from month to month in a year. This monthly effect of course is contrary to the concept of efficient markets, but it gives confidence to investors that there is still a gap to benefit by using information of price and sales volume in past. Ramadhan effect is monthly effect, it has been investigated several time in Islamic countries and it was found that there was a difference in market return during Ramadhan month rather than during any other months. The purpose of this study was to describe the effect of Ramadhan on the stock market return in the Indonesia Stock Exchange (IDX. Ramadhan effect, is a seasonal anomaly in the financial markets, when stock returns during Ramadhan is different from the other. The unit of analysis used in this study is a JSX composite of 1425H-1434H (February 21, 2004 -3 November 2013. The statistical method used to test the hypothesis is nonparametric test (sign test, because the data are not normally distributed. The results showed that there was no influence of Ramadhan on the stock market return in the Indonesia Stock Exchange.  The cause of the lack of differences in returns among others due to the stability of the value of JSX Composite which is basic calculation of returns, but it also may be due to cultural differences and different conditions during the month of Ramadhan between Indonesia and other countries. Investor behavior changes that occur in other countries during Ramadhan does not occur in Indonesia due to the investors’s composition in Indonesia is still dominated by foreign and institutional investors. The results of this study indicate that the capital market in Indonesia efficient in weak form, because the pattern of stock price movement is random or unpredictable  Keywords:Return of stock market, Ramadhan

  2. TIMELINESS LAPORAN KEUANGAN DI INDONESIA (STUDI EMPIRIS TERHADAP EMITEN BURSA EFEK JAKARTA)

    OpenAIRE

    Michell Suharli; Sofyan S. Harahap

    2008-01-01

    This Research examines variables which are predicted influencing timeliness finandal statement in Indonesia. Factors that are predicted influencing timeliness in this research are focused on 4 factors: firm scale, profitability, big 4 worldwide accounting firm , and securities return . This research can examines financial statement of 30 companies are listed Jakarta Stock Exchange for period ended December31, 2002 until December31, 2003. Data is collected from Jakarta Stock Exchange and Indon...

  3. Timeliness Laporan Keuangan di Indonesia (Studi Empiris terhadap Emiten Bursa Efek Jakarta)

    OpenAIRE

    Suharli, Michell; Harahap, Sofyan S

    2008-01-01

    This Research examines variables which are predicted influencing timeliness finandal statement in Indonesia. Factors that are predicted influencing timeliness in this research are focused on 4 factors: firm scale, profitability, big 4 worldwide accounting firm , and securities return . This research can examines financial statement of 30 companies are listed Jakarta Stock Exchange for period ended December31, 2002 until December31, 2003. Data is collected from Jakarta Stock Exchange and Indon...

  4. Pengaruh Rasio Keuangan Terhadap Pertumbuhan Laba Pada Perusahaan Barang Konsumsi Yang Terdaftar Di Bursa Efek Indonesia

    OpenAIRE

    Nasution, Sulfida Syahliza Amin

    2011-01-01

    Profit is the increase in economic benefits during one accounting period in the form of income or assets increase or decrease in liabilities. It is important for users of financial statements to determine the profit growth because of the increased profits from the company will determine the rate of return to shareholders or for prospective investors to take a decision whether to invest in the company. In analyzing and assessing the financial conditions necessary tools of financial analysis of...

  5. TANGGUNG JAWAB SOSIAL BERDASARKAN ISO 26000 DAN NILAI PERUSAHAAN YANG LISTED DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Sri Wahjuni Latifah

    2012-01-01

    Full Text Available The research topic concern with corporate responsibility towards the environment related to the firm value. The objective of this research is to test compliance level of the public company in Indonesia against ISO 26000. The samples in this research are 36 companies which include LQ 45 that was chosen by using purposive sampling method. Techniques of data analysis were conducted by using the index that was analyzed with descriptive statistical techniques. The results of this study found that compliance levels are high (0.68. Similarly, seen from the value of the firm as measured by Tobin’q that the company has conducted environmental responsibility is also high (2.12.

  6. Pengaruh Dividen Inisiasi dan Dividen Omisi terhadap Return Saham di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Azizah Ayu Sielvia

    2011-03-01

    Full Text Available The objective of this study is to determine the effect of dividend initiations and dividend omission of stock returns in Indonesia Stock Exchange (BEI. Variables in this study consist of dividends, dividend announcements, and a significant stock return on dividend announcement reflected the presence of abnormal return during the event period. This study employs the company's shares listed on Indonesia Stock Exchange and are actively traded. Samples used as many as 50 companies, where 37 companies as a dividend initiation and 13 companies as a dividend omission. The sample selection was done by purposive sampling method that is research based on certain criteria. Results of analysis testing the effect of the abnormal return of dividend announcements indicate a significant influence. Announcements of dividend initiations have significant positive influence, while the announcements of dividend omissions have significant negative market reaction. That means the announcement of dividend initiations have a signal or a specific information content that causes the market to react more than normal state of the information, while the announcement of dividend omissions affect investors to remove their stock price moves down or there is a significant abnormal return.Keywords: dividend initiation, dividend omission, dividend announcement, stock return

  7. ANALISIS MODEL PREDIKSI PEMERINGKATAN OBLIGASI SYARIAH PERUSAHAAN DENGAN PENDEKATAN RASIO KEUANGAN DI BURSA EFEK INDONESIA

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    Karima Tamara

    2014-03-01

    Full Text Available This study aimed to determine whether financial ratio was a predictor to predict future bond ratings, and which one was significant. This study concentrates on techniques to predict bond ratings. Bond rating is important because these rankings provide an informative statement and provide a signal about the probability of default of a company's debt. The Islamic bond companies listed in Indonesia Stock Exchange (IDX and assessed by rating agencies PEFINDO in 2009- 2011 were used to answer the research question. Leverage (LTLTA, liquidity (CaCl, solvency (CFOTL, profitability (OIS, and productivity (STA were used as variable of financial ratio. This study examined the financial ratios that can establish sharia bond rating prediction model using discriminant analysis (MDA. The results were : (1 there were different level of Islamic bond in financial ratios of liquidity (CaCl, solvency (CFOTL, profitability (OIS, and productivity (STA; (2 financial ratios, that could form the prediction model of Islamic bonds ranking, were CaCl , OIS , STA, (3 the accuracy level of the formed model were 94.3%.

  8. PENGARUH STRUKTUR KEPEMILIKAN TERHADAP KEMUNGKINAN KESULITAN KEUANGAN PADA BURSA EFEK INDONESIA

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    Indra Hastuti

    2015-10-01

    Full Text Available Financial distresses have strong relationships with the company’s bankruptcy. The financial distress can be predicted by using information contained in the financial statements and the company’s corporate governance mechanisms. The purpose of this study is to prove the effect of ownership structure, liquidity ratios, leverage ratios, activity ratios, and the size of the company to possible financial distress of manufacturing companies in Indonesia Stock Exchange. Populations of this study are manufacturing companies in Indonesia Stock Exchange, which are published in the financial statements from the years 2008-2012,samples of the research  are 156 financial. Data analysis uses a logistic regression .The results of this study indicate that managerial ownership significantly influence of financial distress. While institutional ownership does not significantly influence of financial distress. Liquidity ratios and activity ratios significantly influence of financial distress. While the leverage ratio and firm size had no significant effect on the financial distress. The results can be used for decision making corporate leaders and investors as well as potential investors to always attention Managerial ownership, liquidity ratio, and the ratio of the activity, because these three variables has a contribution in influencing the potential for financial distress.

  9. Pengaruh Perputaran Modal Kerja Terhadap Likuiditas Pada Perusahaan Makanan & Minuman yang Terdaftar di Bursa Efek Indonesia

    OpenAIRE

    Silalahi, Ade Oktavia

    2013-01-01

    Formulation of the problem in this study is whether the turnover of working capital consisting of cash turnover, receivables turnover and inventory turnover affect the liquidity of the company. So this study aims to determine the effect of working capital turnover is comprised of cash turnover, receivables turnover and inventory turnover of the company's liquidity. This study is a kind of causal research and replication of past research is the study population of food and beverage companie...

  10. Simulasi Perdagangan Kontrak Berjangka CPO pada Bursa Malaysia dengan Cyclic Forecasting Periode Januari-Desember 2009

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    Tomy G. Soemapradja

    2011-05-01

    Full Text Available Crude palm oil (CPO is one commodity that could be consumed and also as one alternative of non- fossil fuel: biodiesel. Since 2006, CPO commodity trade has its significant raise, followed by forward contract trade. The increasing of CPO price in 2006 is the lowest in historic analysis data period 2007-2008. Cyclic forecasting model is used following cycle pattern of twice-a-year, with a combination of Solver function in Ms. Excel that could minimize MSE as 161,02, Beta 0,0688 and intercept in -11,0396. Cyclic forecasting period is supposed to be used along with technical analysis, using stop loss to reduce risk. It needs additional research to adjust confidence level so VaR value is not too high that could fix trading strategy along this research. 

  11. Analisis Pengaruh Rasio Camels terhadap Pertumbuhan Laba pada Perusahaan Perbankan yang Terdaftar di Bursa Efek Indonesia

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    Hidayatullah Hidayatullah

    2012-11-01

    Full Text Available This study aims to analyze the influence of CAMELS method of profit growth in banking companies listed on stock exchanges of Indonesia. The methodology this research is t use purposive sampling, namely by taking a sample of 20 from a total of 30 banking companies listed on the Indonesia Stock Exchange. The type of data used are secondary data. Secondary data were obtained in the form of documentation of routine financial statements issued annually by competent parties contained in the Indonesia Capital Market Directory (ICMD and the official site www.idx.co.id. This study tested the effect of CAR, NPLs, NIM, BO / PO, LDR, and the reserve requirement on profit growth at banks listed on the Indonesia Stock Exchange. Techniques of data analysis in this study using multiple linear regression analysis. F test results indicate that the variable CAR, NPLs, NIM, BO / PO, LDR, and the reserve requirement is jointly significant effect on the variable income changes. While partially by t-test, indicates that the variable has positive and significant CAR, NPLs and no significant negative effect, NIM has positive and insignificant, BO / PO and a significant negative effect, LDR has positive and significant, negative effect and the reserve requirement no significant effect on bank profit growth. The results also showed an adjusted R2 value of 18.3%. The limitations of this study is the sample data and the year that is used relatively little. The results of this study is expected to be taken into consideration for management to predict the growth of bank earnings and improve overall performance by improving business efficiency and credit portfolio without ignoring the precautionary principle.

  12. Analisa Korelasi Return Indeks – Indeks Saham terhadap Indeks Harga Saham Gabungan pada Bursa Efek Indonesia

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    Mulyono Mulyono

    2015-08-01

    Full Text Available Stock market generally has the stock price index that measures the performance of stock trading, the Indonesia Stock Exchange has a stock price index that is widely known as Jakarta Composite Index (IHSG. During its development, the Indonesia Stock Exchange has many alternative indexes that measure the performance of stock trading. Research that is to be conducted on the correlation between return of the stock index listed in Indonesia Stock Exchange and return of Jakarta Composite Index. Return stock index listed on the Indonesia Stock Exchange, namely, LQ45 Index, Jakarta Islamic Index (JII, KOMPAS100 Index, BISNIS-27 Index, PEFINDO25 Index and SRI-KEHATI Index, has a close relationship with the return Jakarta Composite,Index which is a reflection of the movement of all existing stock in the market. Return of stocks index that have the highest coefficient correlation is KOMPAS100 In dex, which have return index coefficient correlation is 0.949, thus KOMPAS100 Index that consisting of 100 stocks, based on the results of the study can be used as an alternative investment to get a return that is at least equal or close to the yield given by Jakarta Composite Index(IHSG that consists of 445 stocks

  13. Determinant Keputusan investasi dan Pengaruhnya Terhadap Return Saham Pada Perusahaan Manufaktur di Bursa Efek Indonesia

    OpenAIRE

    Silalahi, Alistraja Dison

    2012-01-01

    Determinant investment decision and its influence to return stock. This research aimed to know whether capital structure, ROI, net profit and firm size are influence to investment decision. This research is also to test and analize the influence of capital structure, ROI, net profit and investment decision toward return stock at manufacture companies in Indonesian Stock Exchange. The population in this research is manufacture companies which are registered in Indonesian stock exchange at ...

  14. PEMODELAN DISTRIBUSI TINGKAT IMBAL HASIL INDEKS HARGA DI TUJUH BURSA ASIA

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    Brady Rikumahu

    2017-03-01

    Full Text Available This paper examines the return distributions of 7 markets in the Asian region, namely Hongkong, Indonesia, Malaysia, Korea, Japan, Shanghai, and Singapore, to find out whether the return distributions in those markets follow a specific distribution. Using data from January 2000 to September 2009, the return distributions of each market were constructed and was first fitted to the normal distribution to find out whether or not each market behaves according to the standard theory of finance and investment – which stated that the financial time series follow a random walk – and thus would fit the normal distribution. The result of fitting the return distributions of the 7 markets to normal distribution shows that none of the return distributions follows the normal distribution as evident from the leptokurtic phenomena marked by the excess kurtosis compared to the normal distribution curve and also from the fatter than normal distribution tails and the existence of returns that lie outside the area predictedby the normal distribution.The return distributions were then fitted to a series of theoretical probability distribution. Each of the distribution was fitted to the theoretical. The results are: the Hongkong and Shanghai markets follow the Laplace distribution while the other five markets: Indonesia, Malaysia, Korea, Japan, and Singapore follow the Johnson SU distribution.

  15. Profitabilitas Strategi Momentum di Bursa Efek Indonesia (Periode Januari 2003 – Desember 2007

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    B Yuliarto Nugroho

    2008-12-01

    Full Text Available Momentum trading strategy present challenges to the concept of efficient market theory. Many studies investigate the profitability of momentum trading strategy in international and domestic equity market and evidence has shown that this strategy could lead to abnormal profit. The purpose of this paper are to examine and analyse the profitability of momentum strategy in the Indonesia equity market from January 2003 to December 2007. This paper also investigates factor such as size and trading volume to identify potential source of profits in momentum strategy. The result of this research show that short-term momentum strategy are profitable on all stock listed on IDX. The findings of the research also show that in the shortterm, trading volume have significant effects and could be potential source of profits in momentum strategy.Keywords: profitability, momentum, size, trading volume

  16. Spatiotemporal Change Detection Using Landsat Imagery: the Case Study of Karacabey Flooded Forest, Bursa, Turkey

    Science.gov (United States)

    Akay, A. E.; Gencal, B.; Taş, İ.

    2017-11-01

    This short paper aims to detect spatiotemporal detection of land use/land cover change within Karacabey Flooded Forest region. Change detection analysis applied to Landsat 5 TM images representing July 2000 and a Landsat 8 OLI representing June 2017. Various image processing tools were implemented using ERDAS 9.2, ArcGIS 10.4.1, and ENVI programs to conduct spatiotemporal change detection over these two images such as band selection, corrections, subset, classification, recoding, accuracy assessment, and change detection analysis. Image classification revealed that there are five significant land use/land cover types, including forest, flooded forest, swamp, water, and other lands (i.e. agriculture, sand, roads, settlement, and open areas). The results indicated that there was increase in flooded forest, water, and other lands, while the cover of forest and swamp decreased.

  17. NILAI TUKAR RUPIAH DAN KINERJA PASAR SAHAM: STUDI EMPIRIK PADA BURSA SAHAM INDONESIA

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    Siti Saadah

    2016-10-01

    Full Text Available This study examines the impact of rupiah exchange rate movement to the stock market performance in Indone-sia, using a dailytime series data from January 2013-December, 15, 2015. Data shows that the characteristic of volatility clustering (heteroskedastic is the reason for applicating TGARCH estimation method in this study. By applicating this method, it shows that the fluctuation of rupiah is in a quite deep depreciation during the period of this analysis, although the cause of stocks return declined but did not lead to investment in Indonesia capital market becomes more risky. This is reflected in the empirical findings of this study, that the volatility of stock returns in the Indonesia Stock Exchange does not increase significantly due to the deprecia-tion trend experienced during the analysis period.

  18. FAKTOR PENENTU RETURN SAHAM DENGAN PRICE TO BOOK VALUE SEBAGAI VARIABEL MODERASI DI BURSA EFEK INDONESIA

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    Sri Lestari Kurniawati

    2017-03-01

    Full Text Available The purpose of this study was to exemine the effect of the company’s financial performance variables consistingof earning growth ratio, dividend payout ratio and size, the variable return equity price to book value as amoderating variable. The samples in this study were all companies listed on the Indonesia Stock Exchangefrom 2005 to 2010 by using purposive sampling with criteria that the company had a positive book value ofequity during the study period. The company splitted the cash dividend and the company did not do corporateactions such as stock splits, reverse stock, stock dividend. The data used in this study were all companies listedon the Indonesia Stock Exchange from 2005 to 2010 (except for companies engaged in finance and banking byusing multiple linear regression to test the interaction or Multiple Regresion Analysis (MRA. The studyfound that the price to book value was not able to significantly moderate the effect of earning growth ratio,dividend payout ratio and size toward the stock return variable for the interaction test results showed thesignificant value was greater than interaction of alpha as 5%.

  19. PENGARUH PENGUMUMAN STRATEGI PENGUNGKAPAN INFORMASI EMITEN PADA RETURN SAHAM DI BURSA EFEK INDONESIA

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    I GEDE SUPARTA WISADHA

    2010-07-01

    Full Text Available The objective of this research is to the empirical test hyphotesis (1 theeffect of the information disclosures strategy to the stocks return.,(2 thelower average abnormal return after the announcement of informationdisclosures strategy then average abnormal return before of theannouncement it, (3 the lower average abnormal return after theannouncement of information disclosurse strategy then average abnormalreturn on the date of announcement it.The methodology of this research is expalanatory survey by usingsecondary data and 154 of listing companys at Indonesia StockExchanges as sample size, the sampling method used is a purposiverandom which category only the company sending the disclosures strategyto the Bapepam. The analysist data method is used the marketmodel(Markowitz with the events study -3 days before and +3 days afterat the date announcement of disclosures strategy.The results of these research are (1 the effect of the informationdisclosures strategy to the stocks return is significantly.,(2 the loweraverage abnormal return after the announcement of informationdisclosures strategy then average abnormal return before of theannouncement has an empirical prove, (3 the lower average abnormalreturn after the announcement of information disclosures strategy thenaverage abnormal return on the date of announcement has an empiricalprove .The conclusion of this research are the results of these research isconsistently with the study before, however the assumption is used didnot the efficient market in the semi-strong form, but in the weak-formespecially for the Indonesia Capital Market.

  20. KANDUNGAN INFORMASI PENGUMUMAN SAHAM BONUS: STUDI EMPIRIS DI BURSA EFEK INDONESIA

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    Lydia Angela Natasya

    2017-03-01

    Full Text Available The aim of this paper was to investigate the market reaction of bonus share announcement in Indonesia StockExchange. Bonus share was the signal given by company to public or stockholders. If bonus shares announcementconsisted of the information, it would be reacted by the market. There were pro’s and con’s about thefinding of bonus share’s announcement. The Standard of event study method had been used for the purpose ofstudying the bonus share issues announcement reaction. The proxies of market reaction were abnormal returnand trading volume activity. In this study, the researcher found a significant negative abnormal return and itmeant that the announcement of bonus share had negative information content. This finding probably meantthat most companies had liquidity problem. The study also found that the average of trading volume activitywas insignificantly decreased after bonus share announcement. This empirical study showed that bonus shareindicated a bad signal for the Indonesia market.

  1. Pengaruh Profitability Dan Investment Opportunity Set Terhadap Dividen Tunai Pada Perusahaan Terbuka Di Bursa Efek Jakarta

    OpenAIRE

    Sadalia, Isfenti; Saragih, Nurul Sari Syafitri

    2010-01-01

    The purpose of the research is to examine the influence of the profitability which is consists of the Return On Equity (ROE) and Net Profit Margin (NPM), and Investment Oppurtunity Set (IOS) which is consists of Market to Book Value of Assets (MVA/BVA), dan Property,Plant & Equipment to the Book Value of Assets(PPE/BVA) to Cash Dividend in Go Public Company as listing at Indonesian Stock Exchange. The result of research indicate that the the profitability which is consists of the Return On...

  2. ANALISIS DEBT FINANCING PADA PERUSAHAAN INTERNASIONAL DAN PERUSAHAAN DOMESTIK YANG TERDAFTAR DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Nilmawati Nilmawati

    2017-03-01

    Full Text Available The purpose of the research was to analyze and find empirical evidence of theeffect of categories of companies (international and domestic on the level of debt using in thelisted companies in Indonesian Stock Exchange by controlling variables such as: risk, profitability,size, tangible fixed asset, growth, and agency problem. Multiple linier regression and chowtest were used for instrument analysis. The results showed that firm category did not effect thelevel of debt using, and there were only 2 control variables (profitability and agency affectingthe level of debt using.

  3. PENGARUH BOND RATING TERHADAP IMBAL HASIL SAHAM DI BURSA EFEK INDONESIA

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    Gatot Nazir Ahmad

    2011-09-01

    Full Text Available The purpose of this study is to determine the effect of bond rating on stock returns. Sample of this study covers 20 firms listed on Indonesia Stock Exchange. The research period is from 2006 until 2008. Controlling for systematic risk, earning per share and liquidity, the result show that bond rating has insignificant effect on stock returns. This suggests the bond rating announcement has no news to the investor. Further, contrast to the theory, the coefficient of bond rating is positive meaning the higher risk the low return and vice versa.

  4. PENGARUH STOCK SPLIT TERHADAP LIKUIDITAS DAN RETURN SAHAM DI BURSA EFEK JAKARTA

    Directory of Open Access Journals (Sweden)

    Wang Sutrisno

    2000-01-01

    Full Text Available Research on stock splits has frequently been undertaken. The results vary, but fundamentally can be classified into two groups. First, the stock split is purely "cosmetic". Second, the stock split has a real effect on stocks. The difference between these opinions raises controversy. The purpose of this study is to examine whether stock splits influence stock liquidity and return of an individual stock as well as in a group of stocks as a portfolio. Overall, the results of this study show that stock splits did influence stock price, trading volume and bid-ask spread but did not influence stock risk and abnormal return from the point of view of an individual stock as well as in a group of stocks as a portfolio. The test of a relationship between bid-ask spread and stock price, trading volume and stock risk for each stock shows that all three variable did not significantly affect the bid-ask spread. On the other hand, the test of a relationship in a portfolio reveals that only stock prices significantly affect the bid-ask spread. Abstract in Bahasa Indonesia : Penelitian mengenai stock split sudah sering dilakukan. Hasil dari penelitian- penelitian tersebut bermacam - macam, tetapi pada dasarnya dapat dibedakan menjadi dua kelompok. Pertama, stock split dinyatakan murni hanya sebagai "kosmetik". Kedua, stock split dinyatakan mempunyai efek yang nyata terhadap saham. Perbedaan pendapat ini sering menimbulkan kontroversi. Tujuan dari penelitian ini adalah untuk menguji kembali apakah betul stock split dapat mempengaruhi likuiditas dan return saham baik ditinjau secara individual untuk masing - masing saham maupun seluruh saham sebagai sebuah portofolio. Secara keseluruhan, hasil dari penelitian ini menunjukkan bahwa stock split hanya mempengaruhi harga, volume perdagangan dan persentase spread, tetapi tidak mempengaruhi varians dan abnormal return baik ditinjau secara individual maupun sebagai sebuah portofolio. Sedangkan pengujian hubungan antara persentase spread terhadap harga, volume, dan varians untuk masing - masing saham menunjukkan bahwa ketiga variabel tersebut tidak berpengaruh secara signifikan terhadap spread. Sebaliknya, jika ditinjau sebagai sebuah portofolio, hanya harga yang mempunyai pengaruh yang signifikan terhadap spread. Kata kunci: stock split, likuiditas, abnormal return, bid - ask spread, return saham

  5. PENGARUH KINERJA KEUANGAN BANK YANG TERDAFTAR DI BURSA EFEK INDONESIA TERHADAP RETURN SAHAM

    OpenAIRE

    ' Sumarno

    2014-01-01

    ABSTRACT Financial performance is information acquired regarding company’s internal condition such as portrayed in financial statements. Financial statement information is composed of various ratios such as liquidity,  activity, profitability, and leverage ratios. The purpose of this study was to assess financial performances of national  private banks which have foreign exchange division based on impact of Debt To Equity Ratio (DER), Loan to Deposit Ratio (LDR), Price to Book Value (PBV),...

  6. Pengujian Fenomena Efek Senin (Monday Effect) dan Weekfour Effectdi Bursa Efek Indonesia

    OpenAIRE

    Silaban, Delia Tika; Alvia, Liza

    2009-01-01

    The objective of this research is to reexamine the anomaly of Monday effect and week four effect at Indonesian Stock Exchange (ISE). Using Jakarta Composite Index from 2003 until 2007 and ANOVA to answer the research questions. The results of this research show that there was no difference return between Monday and Tuesday until Friday. The first hypothesis said that Monday return would be lower than another day return was rejected. And also for the second hypothesis, Monday return would be l...

  7. ANALISIS ANOMALI PASAR PERDAGANGAN PADA RETURN SAHAM DI BURSA EFEK INDONESIA

    OpenAIRE

    Sadalia, Isfenti; Pandiangan, Octavianus

    2010-01-01

    The purpose of this research is to examine and to analyze the day of week effect, week four effect, rogalsky effect and january effect at Indonesian Stock Exchnge. Sample were choosen by Purposive Sampling. For the samples of this research are 34 companies was listed as LQ45 stock during 2008. The data’s analyzed statisctically by using SPSS 16.0 for wondows program such as ANOVA, One sample ttest, and Independent sample ttest. The result of this research show that anomaly of trade day market...

  8. Potential Contributions of Olives and Olive Oil in the Developing Tourism in Mudanya (Bursa)

    OpenAIRE

    UYLAŞER, Vildan

    2017-01-01

    Turkey is the 3rd country in olive production and 4th country in olive oil production in the world. Olive oil and olive farming has significant economic value both in the national and international arena for Turkey. Olive and olive oil, which are irreplaceable ingredients in our breakfasts, many meals and salads in Turkish kitchen, are the primary source of income for the families in Mudanya. Mudanya has a historical past and it has a significant potential in terms ...

  9. LABA AKUNTANSI, LEVERAGE, DAN UKURAN PERUSAHAAN TERHADAP HARGA SAHAM DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Pujo Gunarso

    2017-03-01

    Full Text Available Research data observed in 2008-2010 coincided with the global financial crisis that caused the stock price todecline and could trigger the companies listed in Indonesia Stock Exchange to perform income smoothingpractices, with the condition of the researcher wanted to examine the effect of variable earnings, leverage andfirm size on stock prices. The purpose of this study was to analyze the effect of accounting earnings, leverageand firm size on stock prices of public companies listed in the Indonesia Stock Exchange. The method of dataanalysis used was multiple linear regression analysis. The results showed that some of the first findings ofaccounting earnings and firm size significantly affected stock prices. Both leverages did not significantlyaffect the stock price. The empirical results showed that the higher the accounting profit and the size of thecompany were, the higher the price of shares outstanding was, and conversely the smaller the size of thecompany’s stock price was, the less the price of shares outstanding was. The results of this study supported thetheory and the researches done by Ball & Brown (1968, Susan (2008, Sasongko & Wulandari (2006, Daniati& Suhairi (2006.

  10. Analisis Efficient Market Hypothesis (EMH) di Bursa Saham Syariah, 2005:1 – 2008:11

    OpenAIRE

    Cahyadin, Malik; Milandari, Devi Oktaviana

    2009-01-01

    Study on sharia stocks exchange takes an important place and consideration since transactions and financial activities within a stocks exchange market will determine the mode of market itself and will have impact on economic activities in a country where the market is established. This paper is mainly focused to oversee sharia stocks exchanges in Indonesia, United States, Saudi Arabia, and Malaysia using efficient market hypothesis (EHM) method. Data used in this study were collected from mon...

  11. Analisis Efficient Market Hypothesis (EMH) Di Bursa Saham Syariah, 2005:1 – 2008:11

    OpenAIRE

    Cahyadin, Malik; Milandari, Devi Oktaviana

    2009-01-01

    Study on sharia stocks exchange takes an important place and consideration since transactions and financial activities within a stocks exchange market will determine the mode of market itself and will have impact on economic activities in a country where the market is established. This paper is mainly focused to oversee sharia stocks exchanges in Indonesia, United States, Saudi Arabia, and Malaysia using efficient market hypothesis (EHM) method. Data used in this study were collected from mon...

  12. Penggunaan Hedging oleh Perusahaan Telekomunikasi yang Tercatat Pada Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Basyid Ahmad

    2017-09-01

    Full Text Available The aims of this research were to have a comprehensive understanding on hedging implementation in telecommunication companies and to comprehend the impact of hedge to firm value of the companies. In this research, hedging is the moderating variable between independent variable and dependent variable. The independent variables included profit, firm size, leverage, growth, dividend and liquidity while the dependent variable included firm value. The method used was the ordinary least Square. The samples were taken from 2 telecommunication companies, and the data observed included the quarterly financial data from 2006 to 2015. The findings showed that derivative transactions used as hedge by the companies included cross currency swap, forward and option. Furthermore, the use of hedging foreign exchange was not seen to affect the firm value for the telecommunication company. This is because the 5 moderating variables did not significantly affect the firm value and only 1 moderating variable had a significantly negative effect on the firm value. Keywords: derivative, foreign exchange, firm value, hedge, telecommunication’ companyAbstrak: Tujuan dari penelitian ini adalah untuk menggambarkan penerapan hedging pada perusahaan telekomunikasi publik serta mengetahui dampak hedging terhadap nilai perusahaan. Dalam penelitian ini, hedging merupakan variabel moderating terhadap berbagai variabel yang memengaruhi nilai perusahaan yaitu variabel profitabilitas, firm size, leverage, growth, dividen dan likuiditas. Teknik analisis yang dipakai, yaitu regresi (ordinary least Square. Sedangkan perusahaan yang diteliti sebanyak 2 perusahaan publik dengan data keuangan triwulan sejak tahun 2006 sampai dengan 2015. Hasil penelitian menunjukkan bahwa hedging dilakukan perusahaan telekomunikasi adalah melalui transaksi derivatif, yaitu cross currency swap, forward dan option. Secara umum hedging tidak memengaruhi nilai perusahaan mengingat 5 variabel yang telah dimoderasi tidak berpengaruh signifikan dan hanya 1 variabel yang telah dimoderasi yaitu profitabilitas berpengaruh signifikan negatif terhadap nilai perusahaan.Kata kunci: transaksi derivatif, mata uang asing, nilai perusahaan, lindung nilai, perusahaan telekomunikasi

  13. Determinan Intensitas Transaksi Afiliasi pada Perusahaan-perusahaan dalam Grup Bisnis di Bursa Efek Indonesia

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    Martua Eliakim Tambunan

    2016-08-01

    Full Text Available Abstract. Related party transactions are important corporate actions with the highest incidence rate of all issuers’ corporate actions listed in the Indonesia Stock Exchange. Related party transactions' intensity allows minority holders' expropriation right and affects company's value. This study aimed to analyze the determinants affecting related party transactions’ intensity in companies in the business groups in the Indonesia Stock Exchange. The determinants were ultimate shareholders, good corporate governance (with independent commissioner and the Big Four public accounting firms as proxies, debt to equity ratio, and period of crisis. This study used panel data with quarterly time period from 2006 to 2013. Samples were determined by purposive sampling focusing on companies’ typology, namely companies in the three business groups representing the market capitalization’s three layers. The results showed that ultimate shareholders insignificantly had positive effect on related party transactions’ intensity. Independent commisioners and debt to equity ratio significantly had positive effect on related party transactions’ intensity. The Big Four public accounting firms significantly had negative effect on related party transactions’ intensity. Period of crisis insignificantly had negative effect on related party transactions’ intensity. The determinants as a whole have an effect on the intensity of related party transactions. Keywords: related party transaction, business group, ultimate shareholder, good corporate governance, debt to equity ratio

  14. PENGUJIAN PECKING ORDER THEORY PADA EMITEN SYARIAH DI BURSA EFEK JAKARTA

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    Sutapa Sutapa

    2017-03-01

    Full Text Available The objective of this study was to test empirically whether capital structure decisionof Indonesian firms followed a hierarchy of sources of finance called Pecking Order. Samplesin this study were 29 firms listed in Jakarta Islamic Index (JII from 2001 to 2004. Variabelsused as proxy of Pecking Order Theory (POT were profitability, investment opportunity andfirm size. The results of this study were as follows: a. simultaneously, all proxies for POT couldexplain capital structure at Indonesian Capital Market, b. more profitable firms were lesslevered, c. bigger firms were more levered, d. result for investment opportunity did notsupport hypothesis. Firms listed at JII tended to follow POT in their financing decision. Part ofresults of this study was consistent with study of Wiwattanakantang (1999, Fama and French(2002, Benito (2003 and Mutamimah (2003.

  15. Prediksi Risiko Sistematik Saham-Saham LQ45 Bursa Efek Indonesia

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    A An Arief Jusuf

    2016-06-01

    Full Text Available Beta has been argued, both conceptually as well as empirically. In 1960's, many practitioners used superior advantages in calculation attempted at CAPM theory for investing in asset which has high Beta. Many empirical researches on the later years refused the existence of security market line from CAPM. Afterwards, many practitioners and academicians stated the death of CAPM. Linear regression method could be used to make decision if it had already matched the criteria for Best Linear Unbiased Estimator. Prediction model is a statistic testing which aimsat knowing whether there is a relationship or effect between researched variables. Nonparametric method is an alternative action which is taken when the research model does not match normality assumption. This research, as shown by the use of weekly data, could be free from technical trading problems in predicted systematic risk. While ASII, HRUM, and TLKM stock returns are affected more by other factors. This condition has caused systematic risk not to affect significantly on those stocks. Another result has shown that banking stocks, which became part of LQ45, have higher systematic risk respectively.

  16. Pengaruh Modal Kerja terhadap Profitabilitas pada Perusahaan Food And Beverages di Bursa Efek Indonesia

    OpenAIRE

    Putri Nawalani, Arinda; Lestari, Wiwik

    2015-01-01

    Working capital is defined as capital used by companies to finance daily operations. Working capital can also be interpreted as the whole current assets owned by a company. Working capital is expressed as current assets or short-term assets, such as; cash, mar-ketable securities, accounts receivable, inventory, and other current assets. The purpose of this study is to test the effect of working capital turnover, cash turnover, receivables turnover, and inventory turnover on the profitability ...

  17. ANALISIS PENENTUAN MODEL MERGER-AKUISISI YANG SINERGIS DI BURSA EFEK INDONESIA

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    Muhamad Umar Mai

    2016-10-01

    Full Text Available The aim of this study was as follow: a to examine the differences in financial performance and the value of the firm before and after the merger-acquisition of go public company in Indonesia Stock Exchange for the period of 2000-2012;b to identify and analyze the critical success factors of mergers-acquisitions; c designing a model of synergistic merger-acquisition. Wilcoxon signed ranks test results showed that the financial performance and the value of the company for certain years are different, in the sense of increased, significantly. The determinant factors of successfull merger-acquisition of 30 synergistic firms, are: a current ratio and cash ratio was below the industry average; b debt to asset ratio and debt to equity ratio is above the industry average; c return on investment and return on equity also above the industry average. Analysis of the 30 synergisticbidders firm shows that the company has a very adequate corporate governance mechanism, namely: a more than 50% of its stocks owned by other institutions; b the shares held by the management is below 5%; c the membership of the board of commissioners and directors have an independent boards and outside directors of more than 30%; and d the average number of commissioners as many as six people.

  18. Efektifitas Mekanisme Bonding Dividen dan Hutang untuk Mengurangi Masalah Agensi pada Perusahaan di Bursa Efek Jakarta

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    Zaenal Arifin

    2009-08-01

    Full Text Available Jensen (1986 said that the agency problem can be minimized by reducing the free cash flows in a company. These free cash flows can be reduced by increasing the debt or by increasing the dividend. This theory was developed in the United State of America in which most of the listed companies have a dispersed ownership structure. It is interesting to evaluate the effectiveness of this bonding mechanism for the listed companies in Jakarta Stock Exchange in which most of them have a concentrated ownership structure. The purpose of this research is to examine the effectiveness of this bonding mechanism.By investigating the same sample of listed companies in Jakarta Stock Exchange in 1996 and in 2000, this research discovers that in 1996, the debt bonding mechanism is not effective to reduce an agency problem but it increases the agency problem instead. In 2000, the debt bonding mechanism is still not effective but it does not increase the agency problem anymore. Meanwhile, the dividend bonding mechanism is effective to reduce the agency problem both in 1996 and in 2000. However, the dividend bonding mechanism is avoided by the companies that have a family ownership that closed to a minimum portion of majority or domination.Kata Kunci: Agency Problem, Bonding, Hutang, Dividen, Kepemilikan Keluarga

  19. STRUKTUR KEPEMILIKAN SAHAM TERHADAP KEBIJAKAN UTANG PERUSAHAAN DI BURSA EFEK INDONESIA

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    Luh Gede Sri Artini

    2017-03-01

    Full Text Available This paper examined the effects of insider ownership, institutional investors and shareholders dispersion ondebt ratio by pooled regression model. The research Population was all the firms in LQ 45 in Indonesia StockExchange (IDX from 2009 until 2012, and sampling conducted in this research was purposive samplingmethod. Based on the criteria obtained by purposive sampling, 15 companies were eligible to be utilized as theresearch sample. The results of this research were that the impact of insider ownership was positive significanton debt ratio, the institutional investor had a significant positive impact on debt ratio, shareholder dispersionwas not significantly effect on debt ratio.

  20. FAKTOR-FAKTOR YANG MEMENGARUHI KEBIJAKAN UTANG PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA

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    Christine Dwi Karya Susilawati

    2017-03-01

    Full Text Available In the last several years, there had been an increase on the research emphasized on the agent-principal conceptat financial corporation. The objective of this research was to test empirically the agency concept and theirrelation toward the debt policy of corporations. This research analyzed the factors influencing debt policy atmanufacturing firms in Indonesia. Analyzing instruments in this research was multiple regression analysis.The result of this research showed that firm size, profitability and free cash flow had significant influence todebt policy while managerial ownership, institutional ownership, dividend policy and structure asset did nothave significant influence to debt policy. However, simultaneously the seven variables had significant influenceto debt policy.

  1. Faktor-Faktor yang Mempengaruhi Investor Individu dalam Pengambilan Keputusan Investasi Sekuritas di Bursa Efek Indonesia (BEI)

    OpenAIRE

    Septyanto, Dihin

    2013-01-01

    The goal is to examine and obtain empirical evidence about the factors that affect the behavior of investors in securities investment decision in the Indonesia Stock Exchange using the benefits of financial information (information usefulness ). This study uses causality - explanatory . The study subjects were selected existing individual investors in the Indonesia Stock Exchange 135 respondents . This selection is determined to find out the benefits of financial information in investment , s...

  2. Pengaruh Beta Saham Terhadap Expected Return Dengan Model Capital Asset Pricing Pada Perusahaan Publik Di Bursa Efek Jakarta

    OpenAIRE

    Nasser, Etty M

    2007-01-01

    The objective of this research is to obtain empirical evidence of whether market beta has a significant influence on the expected return. This research examines 30 manufacturing companies listed in Jakarta Stock Exchange during 2001-2005 period. Data are mostly secondary data, obtained from Indonesian Capita! Market Directory and annual reports of the companies from 'Pusat Referensi Pasar Modal Indonesia' in Jakarta Stock Exchange. The statistical method used to test the hypothesis is multipl...

  3. PENGARUH BETA SAHAM TERHADAP EXPECTED RETURN DENGAN MODEL CAPITAL ASSET PRICING PADA PERUSAHAAN PUBLIK DI BURSA EFEK JAKARTA

    OpenAIRE

    Etty M. Nasser

    2007-01-01

    The objective of this research is to obtain empirical evidence of whether market beta has a significant influence on the expected return. This research examines 30 manufacturing companies listed in Jakarta Stock Exchange during 2001-2005 period. Data are mostly secondary data, obtained from Indonesian Capita! Market Directory and annual reports of the companies from 'Pusat Referensi Pasar Modal Indonesia' in Jakarta Stock Exchange. The statistical method used to test the hypothesis is multipl...

  4. Analisis Perbandingan Kinerja Pada Bank Nasional, Bank Campuran, Dan Bank Asing Yang Terdaftar Di Bursa Efek Indonesia

    OpenAIRE

    Angel, Christania Graciella

    2014-01-01

    Bank performance appraisal is based on bank financial report itself. The financial report can be form balance report which give information about the financial position to the outside of bank that can be used of eksternal to assess the level of risk exist in a bank. Based on ownership consist of national bank, mixture bank and foreign bank. These banks has tight compete to show a good performance to the public. This research aimed to analyze the financial performance difference of national ba...

  5. Analisis Pengaruh Hari Perdagangan dan Nilai Tukar terhadap Indeks Harga Saham Gabungan (IHSG di Bursa Efek Indonesia Tahun 2009

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    Erric Wijaya

    2011-09-01

    Full Text Available Before making investment decisions, investors need to analyze the pattern of trading days which change daily because of investors’ behavior in stock trading activity that affects the pattern of daily stock price movements. Changes in macro variables like exchange rates for instance, also can affect share price. To determine the influence of independent variables (day of the week effect and exchange rate on the dependent variable (Jakarta Composite Index (JCI, a research is conducted using multiple linear regression analysis. The initial test uses a test of normality and is resumed by testing multiple linear regression analysis and classical assumption. The hypothesis test uses t-statistics and F-statistics with a significance level of 5%. A descriptive statistics implies that there is an effect of trading days on stock prices. However, using backward stepwise linier regression model and multivariate analysis, the result indicates that there is no effect of trading days on stock prices. Using multivariate data analysis, it is found that stock prices is influenced by exchange rate.

  6. Pengaruh Intellectual Capital terhadap Market Value pada Perusahaan Telekomunikasi yang Terdaftar di Bursa Efek Indonesia Tahun 2006-2011

    OpenAIRE

    Psp, Doni Diwaf; Efni, Yulia; Wijaya, Errin Yani

    2014-01-01

    This study examined the effect of Intellectual Capital (IC) on financial performance. the variable is the Human Capital Efficiency (HCE), Structural Capital Efficiency (SCE) and Customer Capital Efficiency (CCE) to variable Market to Book Value (MB).The population on this research is the entire of telecommunications sector companies that have go public and listed on the Indonesia Stock Exchange (IDX) during the period of 2006-2011. The sampling technique used was a saturated sampling (census)...

  7. ANALISIS PENGARUH MEKANISME CORPORATE GOVERNANCE TERHADAP KINERJA KEUANGAN PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA

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    Hamdani .

    2016-04-01

    Full Text Available This  study  was  conducted  to  analyze  the  effect  of  corporate  governance mechanisms, (Ownership Concentration, Size of the Board of Commissioners, Board  Size,  Komisarin  Independent Audit  Committee,  Debt  Policy  and  Firm Size on financial performance. This research was conducted on a manufacturing company in Indonesia Stock Exchange. The population in this study amounted to 148 companies manufacturing and samples were taken of 20 companies with a passing stage purposive sampling. The data used in this research is secondary data. Data taken from the companies listed  in  Indonesia  Stock  Exchange  in  2010-2012  were  obtained  from  the Indonesian  Capital  Market  Director  (ICMD.  Data  collection  techniques using methods of documentation and analysis techniques using multiple linear regression model. Based on the results of hypothesis testing is known that the variable size of the board  of  directors,  audit  committee  and  manufacturing  company  size  has  no effect on CFROA on manufacturing companies in Indonesia Stock Exchange. Sementra  independent  commissioner  terhdap  CFROA  significant  negative effect on manufacturing companies in Indonesia Stock Exchange. Means that the more the number of independent komasaris sekamin lowering CFROA and vice versa. Variable concentration of ownership, board size and debt policies CFROA significant positive effect on the manufacturing company in Indonesia Stock Exchange Keywords: Corporate Governance Mechanisms, CFROA, Ownership Concentration, Size BOC, Size Independent Commissioner Board, Audit Committee, Debt Policy, Company Size

  8. Analisis Perbandingan Kinerja Keuangan Bank Swasta Nasional Dan Bank Pemerintah Yang Terdaftar Di Bursa Efek Indonesia (Bei

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    Sri Hastuti

    2011-10-01

    Full Text Available Performance or performance of bank is the image of reached achievement in banking operational in all aspect, covering monetary management of bank and ability of bank’s assets had to yield profit efficiently, so bank can stay and compete in the middle of inflation distortion and policy of Bank Indonesia, hence the bank had to have up to standard performance or performance - condition health of bank determined by Bank Indonesia. This research aim to analyse and prove the difference flattens which isn't it in monetary performance Private National Bank and State Bank pursuant to ratioes of CAMEL. Sampel the used to amount to 12 banks, consist of 9 Private National Bank and 3 taken State Bank pursuant to Purposive Sampling with criterion enlist in Indonesia Stock Exchange (BEI, routine deliver financial statement, period of year 2005-2007.

  9. Kebijakan Dividen dari Perspektive Agency Cost Model (Studi Kasus Perusahaan yang Terdaftar di Bursa Efek Indonesia periode 2011-2013

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    Akhmad Hitten

    2016-04-01

    Full Text Available The paper examines the influence of agency theory on dividend policies with free cash flow,maturity, capital structure, and ownership dividend variables. The sample used in this research isIndonesian listed companies with observation period from 2010 to 2013, and the data collectiontechnique used is data pooling or merging data. The data is analyzed with multiple linearregression analysis in SPSS program. The result of this study indicates that free cash flow,maturity, and ownership structure do not influence devidend policies, however capital structureinfluences dividend policies in Indonesian listed companies. The research also implies thatagency cost theory, as the main model of relevance dividend preposition, cannot explaindividend policies in Indonesian Companies. The investors cannot rely solely on dividend policiesin term of investment decisions in the future.

  10. Pengaruh Informasi Laba Akuntnasi dan Arus Kas Terhadap Harga Saham Pada Perusahaan Perbankan Yang Terdaftar Di Bursa Efek Indonesia

    OpenAIRE

    Rona, Elvis Christison

    2010-01-01

    This study analyzed the influence of accounting profit and cash flow statement information to the stock prices of the banking companies that listed in Indonesia stocks exchange since 2006 up to 2008. This study was also intended to know which performances measured have the most significant effect to the stock price. Data that used in this research are financial statements from each company, published through website www.idx.co.id and companies financial data that get from ICMD (Indonesia...

  11. PENGARUH PER DAN EV/EBITDA TERHADAP HARGA SAHAM PERUSAHAAN PADA INDUSTRI BARANG-BARANG KONSUMSI DI BURSA EFEK JAKATA

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    Dini Onasis

    2016-10-01

    Full Text Available Abstrak: Penjualan saham di pasar modal merupakan salah satu sumber pendanaan bagi suatu perusahaan, bagi seorang investor pasar modal merupakan suatu investasi dalam bentuk saham. Bagi seorang Analisis Saham dan Investor, valuation memainkan peran yang berarti pada analisis fundamental. Analisis Saham dan Investor menggunakan valuation untuk menilai suatu perusahaan, dimana valuation digunakan untuk menentukan harga saham suatu perusahaan under atau overvalued. PER dan EV/EBITDA merupakan salah satu dari metode valuation yang sering digunakan oleh analisis dan investor untuk menilai harga saham suatu perusahaan.Penilitian ini menganalisis PER dan EV/EBITDA dan pengaruhnya terhadap harga saham 33 perusahaan yang telah tercatat pada industri barang-barang konsumsi dari tahun 1999 hingga tahun 2001. Variabel yang diteliti adalah PER, EBITDA dan Harga Saham. Pengujian hipotesis dilakukan dengan Uji F statistik dan Uji t Statistik pada taraf nyata 5 %.Hasil uji Simultan menunjukkan bahwa terdapat pengaruh signifikan dari seluruh variabel PER dan EV/EBITDA terhadap variabel Harga Saham. Berdasarkan hasil analisis yang didapat 68,8 % harga saham dapat dipengaruhi oleh PER dan EV/EBITDA secara bersama-sama. Hasil uji Parsial menunjukkan bahwa terdapat pengaruh signifikan dari EV/EBITDA terhadap harga saham. Sedangkan variabel PER tidak menunjukkan pengaruh yang signifikan. Abstract: The sale of shares in the capital market is one source of funding for a company, for a capital market investors is an investment in shares. For an Analysis of Stocks and Investors, valuation plays a meaningful role in fundamental analysis. Analysis of Stocks and investors use to assess a company valuation, which valuation is used to determine a company's stock price under or overvalued. PER and EV/EBITDA is one of the valuation methods are often used by investors to assess the analysis and stock price of a company.This research analyzes PER and EV/EBITDA and the impact on stock prices of 33 companies that have been recorded in the consumer goods industry from 1999 to 2001. The variables studied were PER, EBITDA and stock price. Hypothesis testing is done by the F test statistic and t test statistics at the 5% significance level.Simultaneous test results indicate that there is significant influence of all the variables PER and EV/EBITDA to variable stock price. Based on the analysis results obtained 68.8% stock price may be affected by PER and EV/EBITDA jointly. Partial assay results indicate that there is significant influence of EV/EBITDA on stock prices. While the PER variables showed no significant effect. Keywords: Saham, EV/EBITDA, PER

  12. Analisis Laporan Keuangan Dalam Menilai Kinerja Perusahaan Pada Kelompok Industri Alas Kaki Yang Terdaftar Di Bursa Efek Indonesia

    OpenAIRE

    Nasution, Yasmi Chadijah

    2010-01-01

    The main purpose of this research is to know whether the finance performance in footwear industry that licency in BEI has reached the safety situation or not yet. The writer restricted the evaluation of finance performance by using ten finance ratios. The finance ratios consist of Current Ratio, Quick Ratio, Debt to Equity Ratio, Inventory Turnover, Total Asset Turnover, Gross Profit Margin, Net Profit Margin, Return on Investment, Return on Equity, dan PER. The finance performance is evalua...

  13. PENGARUH MANAJEMEN LABA DAN UKURAN PERUSAHAAN TERHADAP BIAYA MODAL EKUITAS PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA

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    Lisa Kurnia

    2015-07-01

    Full Text Available Lisa Kurnia, 2015. The influence of the earning management and firm size againts the cost of equity capital at the manufacturing companies listed on the Indonesia Stock Exchange 2010-2012 period. This research aimed to (1 find out the influence of the earning management againts the cost of equity capital (COEC at the manufacturing companies listed on the Indonesian Stock Exchange 2010-2012 period, (2 find out the influence of companies size againts the cost of equity capital (COEC at the manufacturing companies listed on the Indonesian Stock Exchange 2010-2012 period. The population in the research were manufacturing companies of consumption goods industry which listed Indonesian stock exchange 2010-2012. Sample selection technique used was purposive sampling method. The sample of this research consist of 81 manufacturing company . The method used was multiple linear regression analysis. Based on the t test result show that earnings management and company size significantly and negatively related to the cost of equity capital.

  14. Pengaruh Investment Opportunity Set Berbasis Pada Harga Saham Terhadap Real Growth Perusahaan Properti Dan Real Estate Di Bursa Efek Indonesia

    OpenAIRE

    Silvia, Ditha

    2013-01-01

    This Study aims to analyze the influence of investment opportunity set (IOS) based on the share price to the real growth of the companies either simultaneously or partially on the real estate and property companies at Indonesian Stock Exchange (IDX). The sampling method used is purposive sampling method with the population of 40 real estate companies and from properties listed on Indonesia Stock Exchange , 28 companies sampled acquired in the period 2009 – 2011 . the data resource in this st...

  15. Peranan Konservatisme Akuntansi dan Faktor Risiko Makro dalam Model Laba Residual: Sebuah Studi di Bursa Efek Indonesia

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    Andry Irwanto

    2015-01-01

    Full Text Available This study examines the association of accounting conservatism, growth and macro-economic risk factors and valuation error of residual income model in Indonesian Stock Exchange. We use beta, book to market ratio, and size as proxies for macro-economic risk. Using sample of 186 companies taken from LQ-45 for the year of 2001 – 2005, we find that accounting conservatism and growth, have no significant influence toward residual income model valuation error. B/M has significant influence toward valuation error and has consistent sign as predicted by theory. Beta and Size has no significant influence toward valuation error. Overall, macro-economic risk factors can explain the valuation error better than accounting-based factors.Future research is expected to find accounting variables that can represent macro-economic risk and test their ability to explain valuation error. Also, future research need to confirm the relevance of accounting conservatism in stock valuation after implementation of IFRS in Indonesia.

  16. Pengaruh Pergantian Auditor dan Kualitas Audit terhadap Opini Audit Going Concern: Studi Empiris Perusahaan Manufaktur di Bursa Efek Indonesia

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    Arlen Djunaidi

    2013-05-01

    Full Text Available This study aims to analyze the effect of auditor switching and audit quality on going concern audit opinion in listed manufacturing companies of the Indonesia Stock Exchange (BEI in the year 2006 to 2008. Auditor switching was marked by a change to the Public Accountant firms (KAP who perform the audits or companies used the services of an auditor different than before. Audit quality is proxied by the scale of the BigFour auditors or non-Big Four. Going-concern audit opinion is the explanation given by the auditor if there is any doubt regarding the ability of the company to survive in the future. This study used 70 samples out of 452 populations, using purposive sampling technique in which the main criterion is the sample company received going-concern audit opinion in the year preceding the auditor switched. Results of the study showed that the change of auditors and audit quality is not a factor in determining going concern audit opinion of the company.

  17. PENGARUH MODAL INTELEKTUAL PADA KINERJA PASAR PERUSAHAAN (Studi Empiris pada Perusahaan Keuangan yang Terdaftar di Bursa Efek Indonesia

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    NI WAYAN YUNIASIH

    2011-07-01

    Full Text Available Intellectual capital is believed to be a contributing factor to companies’ performances and values. Several studies have been carried out on the influence of this capital to a company’s performance. However, the results still show some inconsistencies. Therefore, this study aims at re-evaluating the influence of intellectual capital through the addition of ownership structure as a control variable. Ownership structure needs to be controlled since, in Indonesia, it is likely to be concentrated due to the low rate of investor protection. Intellectual capital is measured by the VAICTM method, while the market performance is determined by the price to book value ratio. The sample is financial companies listed on Indonesian Stock Market during the 2004-2008 periods. The result of the analysis fails to support the hypothesis that intellectual capital is associated with firm’s values. The result probably is an indication that market is incapable to assess the value of a company’s intellectual capital because it has no standardized measure and the limited quantitative disclosure regarding intellectual capital.

  18. Pengaruh Atribut Perusahaan dan Faktor Audit Terhadap Keterlambatan Audit pada Perusahaan yang Terdaftar di Bursa Efek Malaysia

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    Apriayanti Apriayanti

    2014-01-01

    Full Text Available Audit delay is interval of days between balance sheet date and audit report date. The purpose of this research is to analyze the effect of company attributes and audit factors to audit delay. This research uses 611 companies listed in Malaysian Stock Exchange from the period of 2006 until 2011 as sample. The independent variables used are size of the company, debt to equity ratio, profitability, subsidiaries of multinational companies, audit firm size, audit fees, industry type,  age of company, company financial year end, and audit opinion. The method of analysis in this research is multiple linear regressions. The results of this study shows that size of the company, debt to equity ratio, profitability, subsidiaries of multinational companies, audit firm size, audit fees, industry type, age of company, and audit opinion have significant influence on audit delay while financial year end does not have significant influence on audit delay.

  19. Faktor-Faktor Yang Mempengaruhi Perusahaan Dalam Auditor Switchng Pada Perusahaan Pertambangan Yang Terdaftar Di Bursa Efek Indonesia

    OpenAIRE

    Azmi, Laila

    2015-01-01

    Auditor independence issue occupied first position in auditing literature. On the other side, this issue often triggers debate regarding auditor switching. This is related with company action to do auditor switching. Some of past research regarding auditor switching, shows different results. Because of that, another research needs to be done to verify theory of auditor switching. The purpose of this research is to find empirical evidences about the factors that influence mining companie...

  20. DAMPAK RISIKO DEFAULT BANK TERHADAP RISIKO SISTEMIK PERBANKAN DAN RISIKO SISTEMATIK BURSA SAHAM DI LIMA NEGARA ASEAN

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    Buddi Wibowo

    2016-05-01

    Full Text Available Abstract Global financial crisis in 2008 has driven special attention to systemic banking sector risk that cause byindividual bank default. Though, banking crisis significantly affect economic growth and national macroeco-nomic condition. Individual bank default non only affect banking industry but also has serious injured theeconomy. Bank default risk not only affect systemic risk but also systematic risk.ASEAN financial integrationplan raise a need to understand characteristics of ASEAN banking industry. Close relationship and intercon-nection between ASEAN economies will make individual bank default a serious issue that its effect will spreadto all ASEAN economy. This research aimed to investigate the effect of bank default risk on systemic andsystematic risk in 5 ASEAN countries. We find that bank default risk significantlyraised systemic risk, esspeciallyin country with high concentration in its banking industry structure. Big banks tend to more serious effect onsystemic risk. Systematic risk tend to be affected by macroeconomy condition, rather than default risk ofindividual bank.

  1. PRAKTEK PENGUNGKAPAN SOSIAL PADA LAPORAN TAHUNAN DI PERUSAHAAN-PERUSAHAAN YANG TERDAFTAR DI PT BURSA EFEK INDONESIA PADA TAHUN 2016

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    Era Delena

    2018-02-01

    Full Text Available This paper is mainly to get the new perspective on those Indonesian go public companies, which listed in Indonesia Stock Exchange, that presently practice the social disclosure on their annual report and at the same time also aims to find out the type of the industries, size of the companies and the ownership of the companies which effect on the practice of social disclosure in those companies that listed in Indonesia Stock Exchange. Social disclosure practice is divided into 6 categories, among others : environment, energy, employee, product/consumer, society and share holders. Industrial type is divided into: sensitive and non-sensitive industrial. Company ownership is divided into two types: domestic ownership and foreign ownership. While the size of the company is measured based on the  total  asset belongs to the company. These researched data is obtained from 45 public listed companies in Indonesia Stock Exchange by using simple random sampling with multiply regression data analysis method. Based on the regression test with Anova Table, it is known that F 7.362 with p-value 0,000 < alpha 0,05 hence Ho is refused, which means the type, size and ownership of the companies altogether will effect the social disclosure on the annual report on those listed companies at Indonesia Stock Exchange in 2016.

  2. Analisa Environmental Cost pada Perusahaan Non-Keuangan yang Terdaftar di Bursa Efek Indonesia Periode 2011, 2012 dan 2013

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    Kartike Dewi

    2014-11-01

    Full Text Available Environmental damage due to over-exploitation by employers without thinking about environmental improvements result in long-term environmental damage. Allocation of environmental costs, making high expenses on companies that ultimately will reduce net income. This study will examine companies that have great potential to damage the environment, but the company is willing to make the allocation of environmental costs in its income statement, and the company also wants to follow the PROPER program created by the Ministry of Environment for the period 2011 to 2013. The research was conducted using secondary data in www.idx.co.id and www.proper.menlh.go.id. Financial Statements of the company that made the sample examined by checking whether there is environmental damage costs are allocated and check the results of PROPER (Program Performance Rating. This study will determine whether the company identifying, recognizing, measuring and presenting the cost of environmental damage in the Financial Statements. Results obtained from secondary data is that many companies have yet to identify, acknowledge, measure and present the cost of the destruction of nature in the financial statement, the company may have a cost allocation but still use the Incidental Charges account, so that when the pages are checked through www.idx.co.id charge is not visible. It is expected that in the future the company create its own environmental cost allocation account so that it can be easily identified by users of Financial Statements.

  3. STRUKTUR KEPEMILIKAN, MEKANISME TATA KELOLA PERUSAHAAN, DAN BIAYA KEAGENAN DI INDONESIA (Studi Empirik pada Perusahaan di Bursa Efek Indonesia

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    Paulus Basuki Hadiprajitno

    2013-05-01

    Full Text Available This study is to examine the effect of corporate governance (the owners’s character and thegovernance mechanism on agency cost. This research shows that family ownership, financialinstitution ownership, government ownership, and foreign ownership have negative effects onagency cost that is proxied as managerial operation cost and or as assets turnover, compared topublic ownership. Furthermore, ownership concentration of at least 5 percent each is not provento effect the agency cost. Results of other examination show that the proportion of independentboard and the number of board meetings have negative effects to the agency cost that is proxiedas assets turnover. However, these two variables and the number of audit committee meetinghave the opposite effect to the agency cost when it is proxied as managerial operation cost.Theseinconsistencies are caused by the ineffective implementation of corporate governance mechanismin Indonesia even after 10 years of implementation.

  4. FAKTOR-FAKTOR YANG BERPENGARUH TERHADAP SET KESEMPATAN INVESTASI (IOS) PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA

    OpenAIRE

    Yendrawati, Reni; Adhianza, Feby Rezki

    2015-01-01

    The increase inhigh-growth companies and rapidly be characterized by highlevels of investment opportunity set. IOS provides guidance where the value ofthe company as the company's goals dependson investment opportunities and spending in the future. This Study aims to identify and examine the dividend policy, the investment risk, profitability, liquidity, activity and solvency of the investment opportunity set. The population in this study all manufacturing companies listed on the Indonesian S...

  5. Penentuan Struktur Modal Optimal Pada Perusahaan Sektor Properti, Real Estate, dan Kontruksi yang Terdaftar di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    M. Rustam

    2015-04-01

    Full Text Available The purpose of this study is to determine the optimal capital structure of property, real estate, and construction companies listed in Indonesia Stock Exchange. The motivation of this study is due to the current research results are still not able to answer whether the optimal capital structure exists. Based on trade-off theory, the optimal capital structure occurs when a company has a minimum capital cost. However,  it is not explained how much capital structure needed to achieve the company maximum value. In addition, this sample business sector is chosen because there are a numeours firms with an adequate long-term debt which make it possible to examine their capital structure. The method used are the nonlinear regression and Monte Carlo simulation method. These methods were chosen because the formulation of optimal capital structure is arguably complex. There are 47 samples from all property, real estate, and construction companies. The data set covered 11 years ie (2000-2010. The results showed that the optimal capital structure of properties, real estate and construction companies which are measured by the ratio between the long-term debt and equity is 0.99. Most companies of these sectors have not reached the optimal capital structure yet because the average results from these companies are 0.31.

  6. HUBUNGAN ANTARA FLUKTUASI NILAI TUKAR RUPIAH, SUKU BUNGA DAN HARGA SAHAM INDUSTRI MANUFAKTUR DI BURSA EFEK JAKARTA

    Directory of Open Access Journals (Sweden)

    M. Budiantara

    2016-11-01

    Full Text Available In this study, we examine the relation between exchange rate, interest rate, and stock price of manufacturing industries. Despite Engle-Granger procedure and Johansen Criterion, error correction model (ECM of the two variables is employed to simultaneously estimate the short run and long run dynamics of the variables. Using monthly data covering the May 1996 – September 2003 period, empirical results show that there is a causal relation between variables in the crisis period and before the crisis period. The result of the ECM estimation proves that an increase in stock price of manufacturing industries has a positive effect on the exchange rate, because foreign investors enter the domestic stock market. Depreciation of domestic currency has a negative effect on the stock price. In the crisis period, we can prove that the stock price has a significant effect on the exchange rate variable in the long run. We also prove that the effect of the exchange rate on the stock price only occur in the long run. On the other hand, the result of ECM estimation also proves that an increase in deposit rate has a negative effect on the stock price in the long run and in the short run, because the gain from the deposit would be more than the gain from stock exchange, and we also prove that the stock price of manufacturing industries has a significant effect on the deposit rate variable only in the short run. Keywords: exchange rate, stock price, interest rate, Error Correction Model

  7. Pengaruh Corporate Social Responsibility Terhadap Kinerja Keuangan Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia periode 2008-2014

    Directory of Open Access Journals (Sweden)

    Rilla Gantino

    2016-10-01

    Full Text Available This study examine the influence of firm size, firm risk, capital intensity, leverage, tax, litigation, ownership structure, and growth opportunity for accounting conservatism.The study population was 129 manufacturing companies listed in Indonesian Stock Exchange between 2009 and 2011. Based on purposive sampling method, 38 manufaturing companies was selected (or 114 observations. Data was selected from the companies’ financial reports and analysed by using multiple linear regression. This study uncovered that. the firm size, firm risk, capital intensity, leverage, tax, litigation, ownership structure, and growth opportunity have influence for accounting conservatism collectively. But, only firm size, firm risk, capital intensity, ownership structure and growth opportunity affect accounting conservatism individually in the studied companies

  8. Pengaruh Mekanisme Corporate Governance Terhadap Pelaksanaan Enterprise Risk Manegement pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia

    OpenAIRE

    Sitinjak, Mauritz P I

    2016-01-01

    This study aimed to examine the effect of corporate governance mechanism on the implementation of enterprise risk management. Variable corporate governance mechanism in this study consisted of, independent board, board size and audit committee size. The population in this research is manufacturing companies that listed in Indonesia Stock Exchange 2013-2014 period. Sample selection is done by purposive sampling method so that samples obtained for this study amounted to 89 companies. Data an...

  9. Pengaruh Pengungkapan Informasi di Internet dan Status Perusahaan Terhadap Frekuensi Perdagangan Saham Perusahaan Kompas100 di Bursa Efek Indonesia

    OpenAIRE

    Aruan, Beatrice

    2016-01-01

    Because of rapidly growth of internet technology, communication through internet has been adopted by business sector as important tool to share information. Growth of information technology especially internet influenced traditional form of company information disclosure until additional media to disclose financial information that which is Internet Financial Reporting (IFR) has emerged. Then, there are efforts of companies to reduce asymmetry information by disclose information about compani...

  10. Analisis Faktor-Faktor yang Memengaruhi Dividend Payout Ratio pada Perusahaan Sektor Industri yang Terdaftar di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Sunaryo Sunaryo

    2014-05-01

    Full Text Available The primary objective of this research is to learn the effect among return on assets (ROA, current ratio (CR, debt to equity ratio (DER, debt to total assets (DTA, and net income after tax (NIAT with dividend payout ratio (DPR, either partially or simultaneously. Research used qualitative method with secondary data collected by purposive sampling from industrial companies sector listed in IDX and preceding journals of scientific articles. Research used simple regression to test the hypothesis simultaneously with F test and t test for testing the partial hypothesis. Results of this research describe that return on assets (ROA and net income aftar tax (NIAT have significant effects to dividend payout ratio, but current ratio (CR, debt to equity ratio (DER, and debt to total assets do not have significant effects to dividend payout ratio. It is recommended to further research that the topic of this reseach can be continued using merchandising and distribution company groups, or service company groups either general or special, like: hotels, insurances, hospitals, and banks.

  11. Pengaruh Corporate Social Responsibility Disclosure Dan Environmental Performance Terhadap Economic Performance Pada Perusahaan Manufaktur Yang Terdaftar Di Bursa Efek Indonesia

    OpenAIRE

    Saputri, Novitasari; Heriningsih, Sucahyo

    2012-01-01

    This research is aimed to examine effect Corporate Social Responsibility(CSR) Disclosure and EnvironmentalPerformance on Economic Performance.This research used Corporate Social Responsibility Index (CSDI) asmeasure of CSR, Proper Index as measure of Environmental Performance and Return on Equity (ROE) asmeasure of Economic Performance. The samples of this research are 11 manufactur firms listed at IndonesianStock Exchange year 2006 until 2009. The research hyphotesis were tested using mu...

  12. Etiology of Burn Injuries Among 0-6 Aged Children in One University Hospital Burn Unit, Bursa, Turkey

    Directory of Open Access Journals (Sweden)

    Neriman Akansel

    2013-01-01

    Full Text Available Background; Children whose verbal communications are not fully developed are the ones at risk for burn injuries. Causes of burn injuries vary among different age groups and scald injuries are the common cause of burn injuries among children. The majority of burns result from contact with thermal agents such as flame, hot surfaces, or hot liquids.Aim: The aim of this study was to determine etiologic factors of the burn injured children Methods: Data were collected for burn injured children treated in Uludag University Medical Hospital Burn Unit between January 2001 – December 2008. Patients’ demographic variables, etiology of burn injury, TBSA(total body surface area, degree of the burn injury, duration of hospitalization was detected from medical records of the hospitalized patients.Results: The mean age of the children was 2.5±1.5 (median=2. Although 4.6 % of burned patients were under one year of age, most of the children (67.8% were between 1-3 years. All of the patients were burned as a result of accident and house environment was the place where the burn incident occurred. Burn injuries occurredmostly during summer (29.9% and spring (28.7%. Scald injuries (75.3% were mostly seen burn injury types all among other burn injuries.Conclusions: Lack of supervision and observation are usually the most common causes of burn injuries in children. Statistical differences were found among age groups according to their burn etiology (p<0.05. An effect of TBSA on patient survival was statistically significant (p<0.000 and also statistically significant results were seen among age groups according to their TBSA’s (p<0.005.

  13. RESPON MAHASISWA PERBANKAN SYARI’AH TERHADAP PENDIRIAN GALERI INVESTASI BURSA EFEK INDONESIA SEKOLAH TINGGI AGAMA ISLAM NEGERI PAMEKASAN

    Directory of Open Access Journals (Sweden)

    Lely Shofa Imama

    2015-12-01

    Full Text Available BEI Investment gallery STAIN Pamekasan as a realization of capital market laboratory will always engage academician, especially Perbankan Syari’ah students, as the object of the investment gallery. This research is field research employing descriptive quantitative method. Its objective is to identify the level of knowledge and response toward the existence of BEI Investment gallery in STAIN Pamekasan. The result shows that students of Syariah Banking Program just simply know, whereas they absolutely agree with the urgency of laboratory capital market and the founding of BEI investment gallery STAIN Pamekasan.

  14. Pengaruh Mekanisme Corporate Governance Terhadap Peringkat Obligasi Yang Tercatat Di Bursa Efek Indonesia Periode Tahun 2008 – 2010

    Directory of Open Access Journals (Sweden)

    M Mariana

    2016-05-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh mekanisme corporate governance terhadap default risk yang diproksikan dengan peringkat obligasi. Mekanisme corporate governance diproksikan dengan jumlah blockholder, kepemilikan institusi, kepemilikan insider, kualitas audit, komite audit, ukuran dewan komisaris, dan proporsi dewan komisaris independen. Penelitian ini menggunakan leverage, ROA, dan ukuran perusahaan sebagai variable kontrol. Sampel dalam penelitian ini terdiri dari 81 obligasi yang diterbitkan oleh perusahaan yang terdaftar di BEI selama periode 2008-2010 yang telah diperingkat. Penelitian ini menggunakan model analisis ordinal logistic regression untuk menguji pengaruh dari mekanisme corporate governance terhadap peringkat obligasi. Hasil penelitian membuktikan bahwa blockholder, kualitas audit, dan proporsi dewan komisaris independen berpengaruh signifikan terhadap peringkat obligasi. Penelitian ini tidak berhasil membuktikan bahwa kepemilikan institusi, kepemilikan insider, komite audit dan ukuran dewan komisaris berpengaruh secara signifikan terhadap peringkat obligasi.

  15. Pengaruh Faktor Eksternal Terhadap Nilai Perusahaan (PBV dan Harga Saham Terhadap Perusahaan Manufaktur di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Ni Putu Santi Suryantini

    2015-08-01

    Full Text Available The  aims  of this research  i s  to examine  the  influence  of    external  factors on  f irm  value,   the effect  of   companyvalue  on stock  price,  and influence  of  external factors  on  stock  price. The  samples  were 30  manufacturingcompanies  li sted  in  Indonesia  Stock  Exchange  through  pusposive  sampling.  This  study  applied  secondarydata  based  on  documentation  of the  companies.   Data  analysis  was performed  by  using  Smart  PLS.  Out  of thethree indicators of external factors, two of them i.e.  inflation and exchange rate,  met  the criterion,  becausethey have loading factor above 0,5 .  The resul ts  show that, external factors negatively effect firm value withcoefficient  value  of  0.0933,  means  that  i f  external   factors  changes,  company’ s  value  thr ough  PBV ,  movetowar d  negative  di r ection.  V alue  of  company  influence  stock  price  positively  with  coeff icient  value  of   0.0637.Additionally,  external   factors  show  negat ive  effect   on  stock  price  with  coefficient  value  of  0.1019,  as  anindication that the  changes of  external factor  has negative  impl ication to  the  stock price

  16. Pengaruh Biaya Agensi, Tahap Daur Hidup Perusahaan, dan Regulasi terhadap Kebijakan Dividen pada Perusahaan Manufaktur di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Djumahir Djumahir

    2009-01-01

    Full Text Available The purpose of the article was to investigation the influence agency cost that proxy with Dispersion of Ownership; Institutional Ownership; Free Cash Flow, life cycle of the firm and industries regulation on dividend policy in manufacture industry IndonesiaCapital Market (BEI. Agency theory, risk market theory and investment opportunity theory were used to develop theoretical framework to address three hypotheses. Secondary data from Indonesian Capital Market Directory was use to test hypothesis effect agency cost that proxy with Dispersion of Ownership; Institutional Ownership; Free Cash Flow, life cycle of the firm and industries regulation on dividend policy. The number of sample are 31 company as part of 153 manufacturing company in BEI. It pound that agency cost, institusional ownership, free cash flow, life cycle of the firm and industry characteristic simultanously have effcet to dividend policy. As partialy only institusional ownership that not have effect. Meanwile free cash flow is the higest effect to dividend policy. This reserach enrich the fact of empirical study about agency theory, , risk market theory and investment opportunity. Dispersion of Ownership, Free Cash Flow dan Collaterilazable Assets add as proxy agency cost that difference with previous reserach. This reserach offer new information about dividend policy in manufacturer industri in BEI that overall management more concern to minority investor than institutional ownership.

  17. Pengaruh Return on Assets dan Debt to Equity Ratio terhadap Harga Saham pada Institusi Finansial di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Rani Ramdhani

    2013-03-01

    Full Text Available This study aims to determine the effect of Return on Assets and Debt to Equity Ratio of Stock Price on Financial Institutions in Indonesia Stock Exchange. This study used secondary data, with samples 2 financial companies in Indonesia Stock Exchange during the study period 2004-2010. Independent variables in this study are Return on Assets and Debt to Equity Ratio. This study used purposive sampling technique. The method of data analysis used classical assumption test, hypothesis test, multiple regression analysis, the F test and t test. Based on results of the study, Return on Assets and Debt to Equity Ratio have no significant effect on stock price. Meanwhile, the F test result shows that Return on Assets and Debt to Equity Ratio jointly have no effect on stock price.

  18. Analisis Perbedaan Earnings Response Coefficient (ERC) Sebelum Dan Setelah Adopsi IFRS Pada Perusahaan Yang Tercatat Dalam Bursa Efek Indonesia

    OpenAIRE

    Galantika, Fransisca Intan; Siswantaya, I Gede

    2016-01-01

    Convergence of International Financial Reporting Standards (IFRS) causes the Pedoman Standar Akuntansi Keuangan (PSAK) undergo some changes. This then leads to differences in comparability of financial statements declining so that investors from various countries is difficult to make investment decisions. Then appeared IFRS as the global accounting standards as a reference in generating quality of financial reporting. This study aimed to analyze whether there was a significant difference betw...

  19. Pengaruh Rasio Profitabilitas dan Rasio Solvabilitas terhadap Harga Saham pada Industri Makanan dan Minuman yang Terdaftar di Bursa Efek Indonesia

    OpenAIRE

    Pertiwi, Nels Suvanni Kusuma

    2016-01-01

    This research aims to analyze the influence of Profit Margin on Sales (NPM), Return On Investment (ROI), Return On Equity (ROE), Earning Per Share (EPS), Debt to Asset Ratio (DAR), Debt to Equity Ratio (DER), Long Term Debt to Equity Ratio (LTDtER) toward the stock price of food and beverage companies listed in Indonesia Stock Exchange. The design used in this research is causal associative. Population of this research are 19 food and beverage companies listed in Indonesia Stock Exchange d...

  20. Analisis Pengaruh Tingkat Profitabilitas dan Harga Saham Terhadap Volume Penjualan Saham Pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia

    OpenAIRE

    Setiadi, Dedi

    2015-01-01

    The formulation of the problem in this research is the extent to which the influence of the level of profitability and share price of the stock on the sales volume manufacturing companies listed on the Indonesia Stock Exchange. The purpose of this study is to investigate and analyze the effect of the level of profitability and share price of the stock on the sales volume manufacturing companies listed on the Indonesia Stock Exchange. The independent variable in this study is represented by Pr...

  1. PENGARUH STRUKTUR MODAL, KEBIJAKAN DIVIDEN DAN SIZE TERHADAP NILAI PERUSAHAAN(Studi Pada Perusahaan Properti Di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Zainal Abidin

    2016-04-01

    Full Text Available Company has a normative goal to maximize the value of the companies, which aims to maximize shareholder wealth. This study aims to analyze the factors that value effect of the company. The variables used in this study are the Debt to Equity Ratio (DER, Dividend Yield (DYD and Size. The research was conducted on property companies listed on the Stock Exchange, period from 2009 to 2011. The dependent variable in this study is measured by the value of the company’s, Price to Book Value (PBV. The independent variable in this study is capital structure is measured by Debt to Equity Ratio (DER, dividend policy as measured by Dividend Yield (DYD and Size. Sampling was conducted using purposive sampling method which produces 17 companies as the  study  of  a  population  sample  of  52  companies.  The  method  used  in  this research is the analysis of linier regression. This  result  showed  by  together  DER,  DYD  and  Size  has  effect  on  PBV.  The partially  DER  indicated  positive  and  significant  effect  of  PBV.  Size  had  no significant positive effect on PBV. DYD has significant effects and negatively to PBV. Keyword : Debt  to  Equity  Ratio  (DER,  Divident  Yield  (DYD,  Size  and  Proce  to  Book Value (PBV

  2. Potential Cost-Effectiveness of RSV Vaccination of Infants and Pregnant Women in Turkey : An Illustration Based on Bursa Data

    NARCIS (Netherlands)

    Pouwels, Koen B.; Bozdemir, Sefika E.; Yegenoglu, Selen; Celebi, Solmaz; McIntosh, E. David; Unal, Serhat; Postma, Maarten J.; Hacimustafaoglu, Mustafa

    2016-01-01

    Background Worldwide, respiratory syncytial virus (RSV) is considered to be the most important viral cause of respiratory morbidity and mortality among infants and young children. Although no active vaccine is available on the market yet, there are several active vaccine development programs in

  3. PENGARUH CORPORATE SOCIAL RESPONSIBILITY DISCLOSURE TERHADAP RETURN ON ASSETS PADA PERUSAHAAN TELEKOMUNIKASI YANG TERDAFTAR DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Christian Noel Filemon

    2017-04-01

    Full Text Available Dewasa ini, konsep CSR berkaitan erat dengan keberlangsungan perusahaan. Menurut konsep CSR, sebuah perusahaan dalam melaksanakan aktivitas dan pengambilan keputusan tidak hanya berdasarkan faktor keuangan dan keuntungan semata melainkan juga berdasarkan konsekuensi sosial dan lingkungan untuk saat ini maupun masa yang akan datang. Secara teori, CSR dapat dimanfaatkan untuk memaksimalkan nilai pemegang saham, strategi untuk mencapai keunggulan kompetitif dalam jangka panjang, serta sebagai media pemasaran. Selain itu juga dapat mengurangi biaya penyesuaian yang dikeluarkan apabila perusahaan dinilai merugikan masyarakat maupun lingkungan ketika beroperasi. Sebagai salah satu bentuk aktivitas perusahaan, maka setiap kegiatan CSR perlu diungkapkan kepada pemegang saham. Penelitian ini akan membahas tentang bagaimana pengungkapan CSR dapat mempengaruhi financial performance khususnya ROA perusahaan-perusahaan yang berasal dari industri yang bertumbuh tinggi saat ini, yakni industri telekomunikasi, dengan periode penelitian pada tahun 2010 hingga 2013. Penelitian ini menggunakan teknik analisis regresi data panel terhadap lima perusahaan telekomunikasi dengan CSR Disclosure sebagai variabel independen, Return on Assets sebagai variabel dependen dan dua variabel kontrol yakni Leverage dan Company Size. Berdasarkan hasil penelitian, ditemukan bahwa tidak terdapat pengaruh signifikan dari CSR Disclosure terhadap Return on Assets. Di sisi lain, hanya variabel kontrol Company Size yang memiliki pengaruh positif dan signifikan terhadap Return on Assets.

  4. PERATAAN LABA (INCOME SMOOTHING DAN ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHINYA (STUDI PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA

    Directory of Open Access Journals (Sweden)

    NI LUH PUTU ARIK PRABAYANTI

    2011-01-01

    Full Text Available The aim of this research is to identify factors influencing incomesmoothing. Income smoothing is an active manipulation of earnings toward apredetermined target. The target may be set by the management, requested bythe analysts, or expected by a particular group of stakeholders (Chong, 2006.The factors being examined were size of the company, company’s profitabilityratios, company’s financial leverage ratios, company’s institutional ownershipratio and auditor reputation. Index Eckel is used to determine the incomesmoothing practices.The sample of 41 manufacturers listed on Indonesian StockExchange, during a period between 2004-2008.The hypothesis were tested using binary logistic regression. The firsthypothesis was formulated to consisted examine the effect of size of thecompany on income smoothing. The second hypothesis was formulated toexamine the effect of company’s profitability ratios on income smoothing Thethird hypothesis was to examine the effect of company’s financial leverage onincome smoothing. The fourth hypothesis was formulated to examine the effect ofcompany’s institutional ownership ratio on income smoothing. The fifthhypothesis was to examine the effect of auditor reputation on income smoothing.The result of this research showed that some of the listed manufacturerson Indonesian Stock Exchange committed income smoothing practices. Binarylogistic regression showed that just company’s profitability ratios affect incomesmoothing,while size of the company, company’s financial leverage ratios,company’s institutional ownership ratio and auditor reputation did not affect theincome smoothing.

  5. PRAKTEK PENGUNGKAPAN SOSIAL PADA LAPORAN TAHUNAN DI PERUSAHAAN-PERUSAHAAN YANG TERDAFTAR DI PT BURSA EFEK INDONESIA PADA TAHUN 2016

    OpenAIRE

    Era Delena

    2018-01-01

    This paper is mainly to get the new perspective on those Indonesian go public companies, which listed in Indonesia Stock Exchange, that presently practice the social disclosure on their annual report and at the same time also aims to find out the type of the industries, size of the companies and the ownership of the companies which effect on the practice of social disclosure in those companies that listed in Indonesia Stock Exchange. Social disclosure practice is divided into 6 categories, am...

  6. Retrocalcaneal bursitis (image)

    Science.gov (United States)

    Retrocalcaneal bursitis is an inflammation of the bursa at the back of the heel bone. A bursa is a ... bursa to become irritated and inflamed. Symptoms of bursitis include pain in the heel, especially with walking, ...

  7. Four new single nucleotide polymorphisms (SNPs) of toll-like ...

    African Journals Online (AJOL)

    In order to reveal the single nucleotide polymorphisms (SNPs), genotypes and allelic frequencies of each mutation site of TLR7 gene in Chinese native duck breeds, SNPs of duck TLR7 gene were detected by DNA sequencing. The genotypes of 465 native ducks from eight key protected duck breeds were determined by ...

  8. Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans

    Science.gov (United States)

    Ochi, Atsuo; Graffeo, Christopher S.; Zambirinis, Constantinos P.; Rehman, Adeel; Hackman, Michael; Fallon, Nina; Barilla, Rocky M.; Henning, Justin R.; Jamal, Mohsin; Rao, Raghavendra; Greco, Stephanie; Deutsch, Michael; Medina-Zea, Marco V.; Saeed, Usama Bin; Ego-Osuala, Melvin O.; Hajdu, Cristina; Miller, George

    2012-01-01

    Pancreatic ductal adenocarcinoma is an aggressive cancer that interacts with stromal cells to produce a highly inflammatory tumor microenvironment that promotes tumor growth and invasiveness. The precise interplay between tumor and stroma remains poorly understood. TLRs mediate interactions between environmental stimuli and innate immunity and trigger proinflammatory signaling cascades. Our finding that TLR7 expression is upregulated in both epithelial and stromal compartments in human and murine pancreatic cancer led us to postulate that carcinogenesis is dependent on TLR7 signaling. In a mouse model of pancreatic cancer, TLR7 ligation vigorously accelerated tumor progression and induced loss of expression of PTEN, p16, and cyclin D1 and upregulation of p21, p27, p53, c-Myc, SHPTP1, TGF-β, PPARγ, and cyclin B1. Furthermore, TLR7 ligation induced STAT3 activation and interfaced with Notch as well as canonical NF-κB and MAP kinase pathways, but downregulated expression of Notch target genes. Moreover, blockade of TLR7 protected against carcinogenesis. Since pancreatic tumorigenesis requires stromal expansion, we proposed that TLR7 ligation modulates pancreatic cancer by driving stromal inflammation. Accordingly, we found that mice lacking TLR7 exclusively within their inflammatory cells were protected from neoplasia. These data suggest that targeting TLR7 holds promise for treatment of human pancreatic cancer. PMID:23023703

  9. Genetic diversity among some blackberry cultivars and their ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-10-05

    Oct 5, 2009 ... Bursa 3, Chester, Dirckson Thornless, Jumbo, Navaho and Loch. Ness) and a Boysenberry clone were included in this study for. AFLP analysis. While eight of these are known cultivars from North. America, remaining three, Bursa 1, Bursa 2 and Bursa 3, are the blackberry genotypes with unknown origin.

  10. 75 FR 35291 - Foreign Futures and Options Transactions

    Science.gov (United States)

    2010-06-22

    ..., 28981 and 29002. On July 13, 2009, Bursa Malaysia Berhad (Bursa Derivatives' holding company) originally... relevant laws in Malaysia, any regulations promulgated thereunder and Bursa Derivatives regulations; (d... Commission (Commission or CFTC) is granting an exemption to firms designated by Bursa Malaysia Derivatives...

  11. Pengaruh Struktur Kepemilikan Terhadap Nilai Perusahaan Dengan Keputusan Keuangan Sebagai Variabel Intervening Pada Perusahaan Dalam Industri Manufaktur Yang Terdaftar di Bursa Efek Indonesia Tahun 2009

    Directory of Open Access Journals (Sweden)

    Khalisa Rahmina Suryani

    2016-06-01

    Full Text Available This research aimed at empirically proving both direct and  indirect influence of ownership structure to the firm value with financial decision as intervening variable on manufacturing companies listed on Indonesia Stock Exchange 2009. The object is 56 manufacturing companies listed on Indonesia Stock Exchange 2009. This research uses path analysis with SPSS 16.0 version as analizing tools. The result of this study indicate that both institutional ownership and managerial ownership directly and indirectly do not influence the investment decision, the financing decision and the dividend policy. Ownership structure does not influence the firm value.The investment decision influences the financing decision and the dividend policy but the financing decision does not influence the dividend policy. As a whole the investment decision, financing decision and the dividend policy influence the firm value.   Keywords : Ownership Structure, Financial Decision, Firm Value, Path Analysis

  12. ANALISIS PENGARUH NILAI TUKAR, TINGKAT SUKU BUNGA DAN INFLASI TERHADAP INDEKS HARGA SAHAM Studi Kasus Pada Perusahaan Properti yang Terdaftar di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Umi Mardiyati

    2013-04-01

    Full Text Available This study aims to analyze the effect of variable exchange rates, interest rates and inflation on share prices of listed property sector in Indonesia Stock Exchange. The population in this study is a company incorporated in the listed property sector in Indonesia Stock Exchange (BEI for the period from 2007 to 2011. Samples obtained using purposive sampling method to obtain 48 companies. This study uses Ordinary Least Square analysis to determine the effect of independent variables on the stock price index of the listed property sector in Indonesia Stock Exchange. Based on t test, the exchange rate a significant negative effect on property sector stock price index, while the variable interest rates have a positive but not significant and variable inflation is positive but not significant effect on the property sector stock price index. Results simultaneously with the F test showed that all the independent variables significantly influence the stock price index property sector. So that only the exchange rate has an influence on stock price index of listed property sector in Indonesia Stock Exchange.

  13. Pengaruh Internet Financial Reporting dan Tingkat Pengungkapan Informasi Website terhadap Frekuensi Perdagangan Saham Perusahaan Property dan Real Estate yang terdapat di Bursa Efek Indonesia

    OpenAIRE

    Saragih, Veronika

    2016-01-01

    This study was aimed to examine how the influence of Internet Financial Reporting and the level of websites information disclosure on the frequency of company trading stock. The company in this research are property and real estate companies contained or listed in Indonesia Stock Exchange during the years of 2012-2014. The techniques of data analysis used in this research is multiple linear regression analysis using SPSS. There are three types of variables used in this study. Consists of t...

  14. Pengaruh faktor ukuran, pertumbuhan, risiko keuangan, struktur aktiva dan non debt tax shield perusahaan terhadap struktur modal pada Bursa Efek Enam Negara ASEAN

    OpenAIRE

    Situmorang, Christina Verawaty

    2015-01-01

    The objective of the research was to analyze the influence of some factors such as measurement, growth, financial risk, assets structure, and non debt tax shield simultaneously and partially on the capital structure of a real estate company. The population was 285 real estate companies listed in the Stock Exchanges of six ASEAN countries : Indonesia, Malaysia, Philippines, Singapore, Thailand and Vietnam in 2011, and 210 of them with 210 analysis units were used as the samples, using purposiv...

  15. MOTIVASI BONUS, PAJAK, DAN UTANG DALAM TINDAKAN MANAJEMEN LABA (STUDI PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2013-2015

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    Novia Fitri Kusumawardani

    2017-10-01

    Full Text Available The objective of the empirical study is to examine and analyze the influence of Bonus Motivation, Tax Motivation, and Debt Motivation in Earning Management. The variables studied are bonus, tax, debt, firm size, and earning management. The sample of this study is the manufacture company that listed in Indonesia Stock Exchange in 2013 until 2015. The sample used in this study were 165 samples. The classical assumption used is normality test, multicollinearity, autocorrelation, and heteroscedasticity test. Hypothesis test used is the coefficient of determination (R ², simultant test (F-test and invidual test(t-test. The results of this study indicate that (1 Bonus Motivation has positive significant influence in earning management. (2 Tax Motivation has positive significant influence in earning management (3 Debt Motivation has positive significant influence in earning management. Keywords: Earning Management, Bonus, Income Tax, Debt to Assets Ratio, Firm Size.

  16. PENGARUH KEPEMILIKAN MANAJERIAL, KEBIJAKAN UTANG, KEBIJAKAN DIVIDENTERHADAP KINERJA KEUANGAN DAN BIAYA AGENSI (Studi Pada Perusahaan Manufaktur Yang Terdaftar Di Bursa Efek Indonesia

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    Yuni Kusuma Arumsari

    2016-04-01

    Full Text Available This  study  aims  to  analyze  and  explain  the  effect  of  managerial  ownership, debt  policy,  dividend  policy  on  fi nancial  performance  and  agency  costs  in manufacturing companies in Indonesia. This study used quantitative methods with positivism approach. 20 research object manufacturing company. Collecting data using secondary data from annual reports and fi nancial statements. Data were analyzed using path analysis.  The analysis showed that managerial ownership, debt policy, dividend policy affect the fi nancial performance; managerial ownership, debt policy, dividend policy, and fi nancial performance affects the agency costs. The implication of this research is a manufacturing company needs to continue to pay attention to the shares owned by the portion of managerial control in the company, debt mana gement and distribution of large dividends. Thirdly it will lead to improved fi nancial performance so that confl icts of interest and agency costs will decrease.  managerial  ownership,  debt  policy,  dividend  policy,  fi nancial  performance, agency costs  Keywords : Managerial  ownership,  debt  policy,  dividend  policy,  fi nancial  performance, agency costs

  17. Analisis Nilai Perusahaan Melalui Penetapan Struktur Modal Perusahaan (Studi Pada PT. Unilever Indonesia Tbk Dan Anak Perusahaan Yang Terdaftar Di Bursa Efek Indonesia Periode Tahun 2010-2012)

    OpenAIRE

    Khireta, Mirza Ainurani

    2014-01-01

    The purpose of this research was to determine the composition of the capital structure determination of PT. Unilever Indonesia Tbk at years 2010-2012, the determination of the composition of an optimal capital structure, and the value of the company after the composition of the optimal capital structure. Methods used in this research is descriptive. Analysis of data used in this research are counting the ratio of profitability, the ratio of leverage, capital cost, value of enterprise and anal...

  18. Pengaruh Downside Beta, Upside Beta, Dan Beta Terhadap Expected Return (Studi Pada Saham Yang Termasuk Dalam 50 Leading Market Capitalization Di Bursa Efek Indonesia Periode 2012-2015)

    OpenAIRE

    Sinaga, Maria Goretty; Sulasmiyati, Sri

    2017-01-01

    Return or return on an investment is required by the investor. Most investors currently prefer shares in emerging markets. Return in the emerging market is not always symmetrical, it shows return in the emerging market is not normally distributed. The purposive of this research want to learn, compare, and explain about some model of stock risk. On this research downside risk expressed with beta downside. The models used in this research among others, dowside beta, upside beta, and beta. The k...

  19. Pengaruh Asimetri Informasi dan Tingkat Disclosure Terhadap Biaya Ekuitas Dengan Kepemilikan Manajerial Sebagai Variabel Moderating (Studi Empiris Pada Perusahaan Manufaktur Di Bursa Efek Indonesia

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    Ratri Nurjanati

    2016-01-01

    Full Text Available The objective of this research, the first to analyze the effect information asymmetric toward the cost of equity, the second to analyze the effect level of disclosure toward the cost of equity, and the third to analyze the effect the managerial ownership toward the cost of equity of the manufacturing industry which are listed in Indonesian Stock Exchange (IDX in 2010-2013. This research used samples of 35 manufacturing industry which are listed in Indonesian Stock Exchange. The sample selection method used purposive sampling method. The statistical testing were used by Partial Least Square (PLS. The result of this research indicate that (1 information asymmetry have influences significanctly toward the cost of equity, (2 the level of disclosure don’t have influences significantly toward the cost of equity, and (3 the managerial ownership have influences significantly toward the cost of equity.DOI: 10.15408/ess.v5i2.2339

  20. Pengaruh Profitabilitas, Interest Coverage Ratio, Retained Earning, Dan Pertumbuhan Perusahaan Terhadap Peringkat Obligasi Pada Perusahaan Non Keuangan Yang Terdaftar Di Bursa Efek Indonesia Tahun 2012-2014

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    Syawal, Teuku Muhammad; Fachrizal, Fachrizal

    2016-01-01

    The aim of this study is to examine the influence of profitability, interest coverage ratio, retained earning, and growth to bond ratings on non-financial companies listed in Indonesia stock exchange based on the information from the annual financial statement, Indonesia capital market directory, and Indonesia bond market directory with observation ranging from 2012 until 2014. The study type used in this study is hypothesis testing. The type of data used is secondary data. The study employed...

  1. ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PER ANTARA SAHAM YANG TERCATAT DALAM INDEX SYARIAH DAN SAHAM BIASA (Studi pada Perusahaan Non Keuangan di Bursa Efek Indonesia 2006 -2008

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    Ratnaningrum Ratnaningrum

    2011-06-01

    Full Text Available Price Earning ratio (PER shows how much investors are willing to pay per rupiah of reported profit. Since a high PER shows that investor think that the firm has good growth opportunity, so factors determining of PER become very important means to investors in making investment decisions. This study examined the influence of current ratio, debt to equity ratio, return on equity, net profit margin, dividend payout ratio, and inventory turn over  on PER between stock listed in syariah index and common stock of non financial companies in the Indonesia  Stock Exchange (IDX. Samples used in this study consisted on 38 companies listed in IDX and 10 of them listed in Jakarta Islamic Index (JII. The data was analized using regression model and Chow test. The result showed  return on equity has negative influence on the join  PER. This coefficient was contrary with the expectation. This might due to the fact that the PER could increase because of  decreasing of the profit but not from the increasing of the stock price. Other result is a difference of the regression coefficient between stock listed in syariah index and common stock.

  2. ANALISIS BOOK TAX DIFFERENCES TERHADAP PERSISTENSI LABA DAN LABA AKRUAL SEBAGAI VARIABEL MODERATING PADA PERUSAHAAN YANG TERDAFTAR DI BURSA EFEK INDONESIA

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    Bety Pramitasari

    2016-10-01

    Full Text Available The research aims at examining the role of book tax differences to the persistence of earnings and earnings of accruals as moderate variable. This research also include control variable, that is industial factor. The hypothesis alternative is (1a large positive book tax differences influence to  the less persistence of earning; (1b large negative book tax differences influence to the less persistence of earning; (2a large positive book tax differences releated to earning of accruals caused the less persistence of earnings; (2b large negative book tax differences releated to earning of accruals caused the less persistence of earnings. The sample of this reaserch was all companies listed Indonesian Stock Exchange (ISX within the period of 2000-2006. The data ware collected using purposive sampling method, that is taked with based on specific.  The amount of the sample was 50 companies with 160 data to be analyzed. This statistic method used multiple regression. The results of this research showed that large positive (negative book tax differences does not influence to the less persistence of earning. Large positive (negative book tax differences releated to earning of accruals does not cause the less persistence of earnings. The conclusion of the research is information in book tax differences can not measure persistence of earnings and information in accrual of earnings in book tax differences can not measure persistence of earning, so the information in book tax differences can not use to measure future earning  performence.

  3. Faktor-Faktor Yang Mempengaruhi Struktur Modal (Studi kasus pada Perusahaan Manufaktur yang terdaftar di Bursa Efek Indonesia Periode 2011 – 2014

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    Mukhlan Khariry

    2016-09-01

    Full Text Available This study aimed to analyze and test the effects of firm size, tangible assets, profitability, asset growth, sales growth and financial risks to the capital structure of the companies listed on the Indonesia Stock Exchange period 2011-2014. Methods used in this research was quantitative method using manufacturing companies listed on the Indonesia Stock Exchange (BEI in the period of 2011-2014 as the research population. The samples of 54 companies were selected by using purposive sampling method. The study hypothesis was tested by multiple linear regression which have fulfilled classical assumption test. The results showed that firm size (X1, asset growth (X4, and financial risks (X6 had significant influence with the positive directional effect towards the capital structure. Profitability factor (X3 had significant influence with the negative directional effect towards the capital structure. Meanwhile, the factors of tangible asset (X2 and sales growth (X5 had no significant effect towards the capital structure.   Keywords: Firm size, tangible asset, profitability, asset growth, sales growth,    financial risk and capital structure.

  4. PENGARUH MEKANISME GOOD CORPORATE GOVERNANCE (GCG PADA NILAI PERUSAHAAN (Studi Pada Perusahaan Yang Masuk Indeks LQ45 Di Bursa Efek Indonesia

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    Zanera Saroh Firdausya

    2016-04-01

    Full Text Available This study aimed to analyze the effect of managerial ownership, institutional ownership, board size, independent board size, board size and the size of the value of the company on the companies included in the LQ 45 index in Indonesia Stock Exchange. The sampling method used was purposive sampling. Of the population of firms that  enter  in  LQ  45  during  the  period  of  2009-2011,  taken  nineteen  sampel. Alat  companies  that  meet  the  criteria  of  analysis  used  is  multiple  linear regression analysis by first covering the classical assumption of normality test, multikolonieritas, autocorrelation, heteroskedasticity. is partially managerial ownership. While the variable institutional ownership, board size, board size independent, board size and size has no effect on firm value. Keywords: agency theory, corporate governance, corporate performance

  5. ANALISIS REAKSI INVESTOR TERHADAP PENGUMUMAN RIGHT ISSUE DI BURSA EFEK JAKARTA (Suatu Pengamatan pada Return, Abnormal Return, Aktivitas Volume Perdagangan dan Bid-Ask Spread Saham

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    SRI DEWI YUSUF

    2012-05-01

    Full Text Available ABSTRACT Development of stock market activity, which grows very fast lead to significant changes on the demand of information quality. To make the rational investor decision making, it is needed a relevant information in order to identify any work of the company. Event study is a study which analyze any market reactions toward an event which the information is published as announcement. Right issue announcement can affect market, it is depent on the existence of the content of the information in the right issue announcement above. If the right issue announcement contains some information so the market will react and the market won’t react if no information. The research sample is determined by a purposive sampling method, and there are 17 companies which announce right issue between 2000-2003. Statistical experiment used is T-test experiment (paired two samples for means. The Observation period which is done in 11 day, consist of 5 day before, 1 day in the moment, and 5 day after the announce right issue. Results show that there is a significant difference between return and abnormal return in the period of between at the moment, and after the announce right issue. The result in the before-after announce right issue period shows that there is no significant difference. The result in the variable activity of stock’s trade volume shows that there is signification difference in the before-at the moment and after period, but in the result of before-after period show that there is no significant difference there. And the result of bid-ask spread variable shows that there is no significant different in the before-at the moment and after period of announce right issue, but in the before-after period the result shows that there is no significant different there. And the result of bid-ask spread variable shows that there is no significant different in the before-at the moment and after period of announce right issue, but in the before-after period the result shows that there is significant different there. Cumulatively, this research gives a conclusion that announcement right issue have no information contents positive so that the market in general give no reaction. Keywords: Right Issue announcement, Return, Abnormal Return, TVA, Bid-Ask Spread

  6. PENGARUH VARIABEL INTERNAL DAN EKSTERNAL PERUSAHAAN TERHADAP RISIKO SISTEMATIS SAHAM PADA KONDISI PASAR YANG BERBEDA (STUDI PADA SAHAM-SAHAM ILQ 45 DI BURSA EFEK JAKARTA

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    Nining Setyowati Dwi Andayani

    2012-05-01

    Full Text Available ABSTRAK   Fluktuasi harga saham di pasar modal sebagai cerminan ketidakpastian kondisi pasar secara langsung maupun tidak akan berpengaruh terhadap pertimbangan investor dalam mengambil keputusan investasi.  Investor yang rasional, pengambilan keputusan investasi didasarkan pada penilaian return maupun risiko yang terkandung dalam alternatif investasi.  Penelitian ini bertujuan untuk mengetahui pengaruh kondisi internal dan eksternal perusahaan terhadap risiko sistematis saham pada kondisi pasar yang berbeda. Data yang digunakan adalah data sekunder berupa data laporan keuangan harga saham.  Populasi penelitian adalah seluruh emiten yang masuk dalam perhitungan indeks LQ45 selama periode 1999 sampai 2003.  Pengambilan sampel dilakukan dengan teknk purposive sampling dan menghasilkan 15 emiten yang memenuhi syarat ditetapkan sebagai sampel. Dengan melakukan analisis regresi linier berganda terhadap variabel penelitian, diperoleh hasil bahwa secara simultan variabel-variabel internal dan eksternal perusahaan berpengaruh terhadap risiko sistematis saham pada kondisi pasar bullish maupun bearish. Secara parsial, variabel TATO, DER, ROI, PER berpengaruh secara signifikan terhadap risiko sistematis saham pada kondisi pasar bullish, dengan variabel TATO yang dominan mempengaruhi.  Sedangkan pada kondisi pasar bearish, variabel CR, TATO, DER, PER, PBV, dan AS berpengaruh secara signifikan terhadap risiko sistematis saham, dengan variabel AS yang dominan mempengaruhi.   Kata kunci: risiko sistematis, pasar bullish, pasar bearish     ABSTRACT   Fluctuation of stock price in the capital market as an indicator of uncertainty market, it can influence any investment decision of investors. Any rational investors, their investment decisions  are based on return valuation and risk assessment in any investment alternatives.  This research aimed to analyze effects of internal and external variables on the systematic risk of stock at different condition of market. Secondary data used ion this research are  financial report of stock price. Research population is all of emiten which involve in calculation of LQ45 indexes during periode of 1999 – 2003. Purposive sampling is used in this research and result in 15 emiten as a research sample. Results of research show that internal and external variables simultaneously  influence the systematic risk of stock at the bullish market and bearish market. Partially, variables of TATO, DER, ROI, PER significantly influence the systematic risk of stock at bullish market, the dominant variable is TATO.  At the bearish market condition, variables of  CR, TATO, DER, PER, PBV, and AS significantly influence the systemnatic risk of stock, the dominant variables is AS.   Keywords: systematic risk, bullish market, bearish market.

  7. Enfermedad de Gumboro. Histopatología de la Bursa de Fabricio en la enfermedad natural y experimental en pollos de engorde

    OpenAIRE

    E, Babaahmady; R, Joa.-; Julia, Noda.

    2005-01-01

    La Enfermedad de Gumboro, o Enfermedad Infecciosa de la Bolsa de Fabricio (EIBF) es una enfermedad viral, infectocontagiosa de los pollos jóvenes, que puede afectar al pollo de engorde provocando inmunosupresión y mortalidad. Las cepas del virus EIBF se diferencian en su patogenicidad basado en el efecto que producen en los órganos linfoides principalmente la bolsa de Fabricio y como consecuencia la reducida respuesta inmune a infecciones con otros patógenos o vacunas que se aplican. En este ...

  8. PENGARUH INTELLECTUAL CAPITAL TERHADAP KINERJA KEUANGAN PADA PERUSAHAAN RETAIL YANG TERDAFTAR DI BURSA EFEK INDONESIA (BEI PADA TAHUN 2009 – 2011

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    Nono Supriatna

    2013-04-01

    Full Text Available The research aims to examine the influence of intellectual capital to company’s financial performance (profitability, productivity, and market valuation. Profitability measured by Return On Asset (ROA, productiviy measured by Asset Turn Over (ATO, and market valuation measured by Market to Book Value (MB. Independent variabel used in this research is intellectual capital which measured by VAIC™, while dependent variable are ROA, ATO, and MB. In this research, the authors used a quantitative verificative. Data obtainable from retail company listed in Indonesia Stock Exchange (IDX year period 2009-2011. The samples in this research using the method of purposive. Based on sampling criteria the final sample in this research is 7 retail companies. This research use simple linear regression for data analysis. From the research that has been done shows that intellectual capital has positive influence to profitability, intellectual capital has negative influence to productivity, and intellectual capital has no effect to market valuation.

  9. ANALISIS ABNORMAL RETURN SAHAMSEBELUM DAN SESUDAH PENGUMUMAN PERATURAN LOAN TO VALUE KPR(Studi Pada Perusahaan Properti Di Bursa Efek Indonesia

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    Dwi Suharyanto

    2016-04-01

    Full Text Available This study aims to analyze the abnormal stock return of property companies in Indonesia Stock Exchange as a result of the announcement of Bank Indonesia on  the  restriction  of  the  maximum  Loan  to  Value  (LTV  of  the  mortgage loans.  This  study  uses  event  study,  which  observed  the  average  abnormal return over the 10 days prior to the announcement up to 10 days thereafter. The  results  showed  that  there  was  no  signifi cant  difference  between  the abnormal  returns  before  and  after  the  announcement.  However,  there  is  an increase  in  the  number  of  days  that  experienced  abnormal  returns,  ie  2 (two  days  in  the  period before the announcement of a 5 (fi ve days in the period thereafter. While at the moment of announcement there is no abnormal return. This suggests that the effect of the  announcement  was  not  immediately responded by the market, but there is a lag time for the market to react. These conditions may be caused investors do not have the experience to identify and measure the impact of LTV mortgage regulation. Signifi cant  abnormal  return occurs also varies, which is experiencing abnormal gain 3 days and 4 days of having abnormal loss, which shows the confusion in the market so it happened a few times stock price correction. Another possibility for the market considers these policies also have a positive side. Properties company performance may be declining, but the industry would likely have a positive impact in the long run because it will reduce the risk of price bubbles. Keyword : Abnormal Return, Event Study, Mortgage Loan, Loan to Value.

  10. Pengaruh Opinion Shopping, Reputasi Auditor, Disclosure, dan Ukuran Perusahaan terhadap Penerimaan Opini Audit Going Concern pada Perusahaan Manufaktur 2011-2013 yang Listing di Bursa Efek Indonesia

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    Diyanto, Volta; Putri, Tria Widiastuti

    2014-01-01

    The users of financial statements need informations as a basic of their economic decision making. Not only in judging the fairness of financial report or detecting a fraud, but also auditors have responsibility to judge the company ability to maintain company going concern. Going concern audit opinion defined as opinion state by the auditors based on their audit, concludes that substantial doubt exists with regard to the company€™s ability to continue functioning as a business entity.In this ...

  11. Analisa Pengaruh Karakteristik Perusahaan terhadap Tingkat Pengungkapan Tanggung Jawab Sosial Perusahaan pada Perusahaan High Profile yang Tercatat di Bursa Efek Indonesia pada Tahun 2005-2007

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    Muhammad Yusuf

    2011-05-01

    Full Text Available This research is to examine corporate social responsibility disclosure and its level in Indonesian companies. Based on a review of previous researches, six independents variables are extracted for a multiple regression analysis. They are company size, profitability, age, leverage, liquidity, and public ownership. The technique for examining multiple regression analysis by using spss 11,5 programs. Samples of this research are 41 high profile companies that listed in Indonesia Stock Exchange in 2005, 2006, and 2007 acquired using purposive sampling method. The results of this research sowed that on significance rate of 5%, the company size, age, leverage, and liquidity has a significance effect with corporate social responsibilities disclosures. While for the profitability and public ownership has no effect with corporate social responsibilities. These results generally coincide with previous research findings on corporate social responsibilities disclosures.

  12. ANALISA DAMPAK KONVERGENSI IFRS KE DALAM PSAK 13, 16, DAN 30 TERHADAP AKTIVITAS PERDAGANGAN SAHAM PERUSAHAAN YANG TERDAFTAR DI BURSA EFEK INDONESIA

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    Arya Maulana

    2014-03-01

    Full Text Available The application of PSAK has been revised in reference with the IAS in the convergence of IFRS perspective. The objective of the research is to elaborate influence of this application on Trading Volume Activity (TVA companies that implement it. This research uses quantitative method that focus to a single incident within a certain period of publication an annual financial statements of 56 companies who implemented PSAK 13, 16, and 30 revised in 2007. This study indicates that the publication of financial statements has not give a significant influence on the TVA despite there is an increase in trading activity at the time after publication.JEL Classification : M 41, L51Keywords : IAS, PSAK, Financial Statement Publication, Trading Volume Activity

  13. Pengaruh Komite Audit Terhadap Kualitas Pelaporan Keuangan Dengan Kualitas Audit Sebagai Variabel Moderating Pada Perusahaan Manufaktur Di Bursa Efek Indonesia (Bei)

    OpenAIRE

    Puspa, Wywyk

    2015-01-01

    Financial report is one of stakeholder’s tools for making decision, therefore financial report are expected to have qualitative characteristics, which are relevant and reliable. To reduce the delay in submitting financial report, companies create good corporate governance mechanism. One of them is audit committee. The purpose of this study is to analyze the effect of audit committee to financial report quality and audit quality as moderating variable. The population in this study are all m...

  14. Pengaruh Good Corporate Governance Terhadap Kinerja Keuangan Perusahaan Property dan Real Estaate yang Terdaftar di Bursa Efek Indonesia (BEI) Tahun 2010 - 2013

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    Admi, Aldy Pelita

    2015-01-01

    The purpose of this research is to test the influence of Good Corporate Governance to financial company performance. Public ownership, size board of directors, activity of board commissioners meeting and proportion independent commissioners are independent variables in this study and the company's financial performance as dependent variables which is proxied by cash flow return on assets (CFROA). The population of this research are property and real estate companies that listed in the y...

  15. Pengaruh Good Corporate Governance Terhadap Kinerja Perusahaan Property Dan Real Estate Yang Terdaftar Di Bursa Efek Indonesia Tahun 2008-2010

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    Alhamdi, Ridha

    2013-01-01

    The purpose of this research is to know the influence of Good Corporate Governance to company performance. Board of commissioners, independent commissioners, board of directors and audit committee are independent variables in this study and the company's financial performance as dependent variables which is proxied by return on equity (ROE). The population of this research are property and real estate companies that listed in the year 2008 up to 2010, which publishes an annual report and a...

  16. Analisis Prediksi Kebangkrutan Menggunakan Metode Altman (Z-Score Pada Perusahaan Farmasi (Studi Kasus Pada Perusahaan yang Terdaftar di Bursa Efek Indonesia Tahun 2011 – 2015

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    fitria wulandari

    2017-06-01

    Full Text Available This study aimed to analyze the condition of the company using the Altman Z-Score to predict the potential bankruptcy of the five pharmaceutical companies listed on the Indonesia Stock Exchange in 2011 to 2015. The sampling method  is using purposive sampling with a sample of five pharmaceutical companies. This research is descriptive with quantitative approach. The results showed that: (1  in 2011 to 2015 the five pharmaceutical companies are in the good category, the number of  Z-Score from all companies are  ≥ 2.99. (2 Moreover  from the five pharmaceutical companies that were analyzed PT Merck Tbk in 2011, 2013 and 2014 had the highest number for Z-Score at 8.45, 6.3 and 5.92. (3 PT Kalbe Farma Tbk in 2012 and 2014 had the highest number for Z Score at 6.08 and 5.91. The results of this study are expected for pharmaceutical companies to maintain liquidity to meet all its obligations so that will interest   investors and creditors. Companies are expected  to manage assets to increase sales and generate profits.

  17. ANALISIS PERATAAN LABA ( INCOME SMOOTHING : FAKTOR YANG MEMPENGARUHINYA DAN PENGARUHNYA TERHADAP RETURN DAN RISIKO SAHAM PERUSAHAAN GO PUBLIC DI BURSA EFEK JAKARTA

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    Zulfa Irawati

    2008-06-01

    whether there was risk ( beta difference between smoother aand non smoother. This hypothesis was tested with independent sample t test and concluded that there was no risk (beta difference between smoother and non smoother.

  18. Pengaruh Determinan P/e Dan P/e Rasio Terhadap Kepemilikan Institusi : Studi Di Bursa Efek Indonesia Tahun 2004-2008

    OpenAIRE

    Anggraini, Mita; Mahastanti, Linda Ariany

    2012-01-01

    Institutional investors needs analysis in making decisions for investing activities. Analysis of the most widely used is the fundamental analysis approach is through a P/E ratio. P/E (price earnings ratio) can be interpreted as an indicator of market confidence in the company's growth prospects in the future. High P/E indicates that the better performance of the company and this caught a lot of institutional investors to buy shares so that the percentage of institutional ownership in the comp...

  19. Faktor-Faktor yang Mempengaruhi Pengungkapan Corporate Social Responsibility di dalam Laporan Sustainability (Studi Empiris Pada Perusahaan yang listing di Bursa Efek Indonesia Tahun 2010-2013

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    Dita Rohmah

    2016-01-01

    Full Text Available The study aims to examine the effect of corporate governance, firm size, and profitability to corporate social responsibility disclosure in sustainability report. The mechanism of corporate governance used are independent commissioner, institutional ownership, and foreign ownership.This research is a quantitative study using scientific research in the form of positive economics. The nature and type of this research is descriptive with the method used by literature survey. Data used is secondary data obtained from www.idx.co.id and corporate websites. The analytical method used is multiple linear regression analysis with SPSS version 22. The populations in this study are all companies listed on the Indonesia Stock Exchange during the period 2010 until 2013. Samples are taken by purposive sampling method amount 21companies with 4 years observation. Based on the results of multiple regression analysis with a significant level of 5%, the results of this study concluded that: (1 Independent Commissary does not signicantly influence the effect on the disclosure of CSR in the sustainability report with the significant value 0.390 > 0.05. (2 Institutional Ownership has a significant effect on the disclosure of CSR in the sustainability report with the significant value 0.003 < 0.05. (3 Foreign Ownership does not signicantly influence the effect on the disclosure of CSR in the sustainability report with the significant value 0.221 > 0.05. (4 Firm Size has a significant effect on the disclosure of CSR in the sustainability report with the significant value 0.000 < 0.05. (5 Profitability has a significant effect on the disclosure of CSR in the sustainability report with the significant value 0.001< 0.05.DOI: 10.15408/ess.v5i2.2347

  20. Pengaruh Kebijakan Dividen, Earning Volatility, dan Leverage terhadap Volatilitas Harga Saham pada Perusahaan Non-financing yang Terdaftar di Bursa Efek Indonesia Tahun 2010-2014

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    Jannah, Raudhatul; Haridhi, Musfiari

    2016-01-01

    The research examines the effect of dividend policy, earnings volatility, and leverage on share price volatility of non financing companies listed in Indonesia Stock Exchange in 2010-2014. Dividend policy variabel using dividend payout ratio and leverage variabel using debt to equity ratio. Secondary data were sourced from the financial statements, published by the capital market reference center at the Indonesia Stock Exchange. The research type used in this research is hypothesis testing, b...

  1. PENGARUH MANAJEMEN ASET, MANAJEMEN LIABILITI, MANAJEMEN ASET LIABILITI TERHADAP ECONOMIC VALUE ADDED (EVA PADA PERBANKAN KONVENSIONAL YANG TERDAFTAR DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    H Hamidah

    2013-08-01

    Full Text Available Generally, company wants to optimize its profit. Properly manage the asset management, liability management and asset liability management can provide value added profits for the company. A sample of research consists of 18 banking companies listed at Indonesia Stock Exchange (IDX during the 2005-2009. This research investigate the relationship net loans/total earning assets (NLA, non performing loan (NPL, liabilities/total assets (LA, equity/total assets (EA, net interest margin (NIM, loan to deposite ratio (LDR on economic value added (EVA. The research use regression of panel data. The result show that net loans/total earning assets (NLA, liabilities/total assets (LA, equity/total assets (EA, net interest margin (NIM, loan to deposite ratio (LDR are have significant effect on economic value added (EVA but non performing loan (NPL.

  2. Pengaruh Indikator Rasio Keuangan Perusahaan Price Earning Ratio (PER dan Price to Book Value (PBV terhadap Return Portfolio Saham di Bursa Efek Jakarta

    Directory of Open Access Journals (Sweden)

    Barbara Gunawan

    2016-02-01

    Full Text Available This emerged during a kind of perception that the financial statements do not quite believable as the basis of capital market investment decisions. Using the results of the ratio of the financial statements as an object to be examined, the study will look at the extent of the influence indicator Price Earning Ratio and Price to Book Value of the Return Portfolio Shares on the Jakarta Stock Exchange. The results showed that of the portfolio is formed, it turns out the low indicators of Price Earning Ratio and Price to Book Value does not affect the portfolio return.

  3. ANALISIS FAKTOR YANG MEMPENGARUHI AGRESIVITAS PAJAK (Studi Empiris Pada Perusahaan Manufaktur Yang Terdaftar di Bursa Efek Indonesia Pada Tahun 2012-2014

    Directory of Open Access Journals (Sweden)

    Luke Luke

    2016-05-01

    Full Text Available This study aims to examine empirically the effect of corporate social responsibility (CSR, return on asset (ROA, inventory intensity, and size of firm to tax aggressiveness. The population of this research was all manufacturing companies listed on the Indonesia Stock Exchange in the period 2012-2014. Sampling technique used was purposive sampling method. There were 190 companies that fulfilled the criteria of sampling. The result of this study showed that corporate social responsibility (CSR and inventory intensity have negative significant influence to tax aggressivensess. Meanwhile, return on asset (ROA and size of firm have positive significant relationship to tax aggressiveness.

  4. ANALISIS VARIABEL-VARIABEL FUNDAMENTAL YANG BERPENGARUH TERHADAP PRICE EARNING RATIO SEBAGAI DASAR PENILAIAN SAHAM (Studi Pada Saham-Saham indeks LQ 45 di Bursa Efek Jakarta

    Directory of Open Access Journals (Sweden)

    Yulianti - -

    2012-05-01

    Full Text Available ABSTRACT   The existence of the Indonesian Capital Market is very important for Indonesian economic activity, due to the fact that capital market development is one indicated of the betterment of national economy. In terms of investment, capital market development is determined by the economic fundamentals, public company performance, and investor’s tendency to invest. Stock, being the main investment object, offers several preferences to choose by the investor, one of which is LQ 45 stock indices. The Jakarta Stock Exchange (JSX focus is put on the trade of LQ 45 stock indices. Therefore, it is necessary to evaluate the LQ 45 stock indices by taking into account the four main variables as suggested by the Gordon model. In line with the above, this study concerns stock evaluation based on the fundamental analysis by the price earning ratio approach. Explanatory variable is dividend payout ratio, return on equity, earning growth and financial leverage, dependent variable is price earning ratio. Purposive random sampling and multiple regression using 16 emittent of LQ 45 stock indices samples were used]. The aims of this research is to know the influence of the fundamental variables on the price earning ratio, and the naturalness of LQ 45 stock indices value. The samples used are the big, established and stable companies included in  calculation of LQ 45 indices, and thus would not apply to non LQ 45 indices at the JSX from 1999 through 2000. The results of the study indicate that (1 out of the four explanatory variables used: dividend payout ratio, return on equity, earning growth and financial leverage whereas simultaneously, all the variables showed significant influence; (2 dividend payout ratio was the most significant explanatory variable influencing the price earning ratio; (3 based on the price earning ratio analysis, no natural value was evidence of LQ 45 stock indices at the JSX.   Keywords: Price Earning Ratio as Bases in Stock Valuation

  5. Pengaruh Current Ratio, Debt to Equity Ratio, dan Devidend Pay Out Ratio terhadap Price Earning Ratio pada Kelompok Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Sunaryo Sunaryo

    2011-11-01

    Full Text Available The primary objectives of this research is to learn correlation and effecting among CR, DER, and DPR with PER neither partial nor simultaneous. Data secondary collected by industrial random sampling groups listed at IDX and the journal preceding research persons. The results of the research describe that CR and DER have not any effecting significant, negative medium correlation for CR, and negative high correlation to PER, and DPR have effecting significant, positive low correlation to PER. But CR, DER, and DPR have the effecting significant simultaneous to PER. Recommended that the topic of this research can be continued with merchandising company groups, or service company groups either general or special service company groups likely banking, hotel, or insurance, or added with new independence variables. 

  6. How parental attitudes affect the risky computer and Internet usage patterns of adolescents: a population-based study in the Bursa District of Turkey.

    Science.gov (United States)

    Uncu, Yeşim; Vural, Pinar; Büyükuysal, Cağatay; Alper, Züleyha; Kiliç, Emine Zinnur

    2014-12-01

    We aimed to evaluate the computer usage patterns of adolescents and to determine the effects of family life and parental attitude on these patterns. This was a descriptive, cross-sectional, population-based survey that included 935 children between 11 and 16 years of age who were students in the second level of primary school and their parents as well. The following instruments were used in the survey: student and parent questionnaires on computer usage patterns and the Parental Attitude Research Instrument (PARI) to assess parental attitudes towards child-rearing and family life. Of the study population, the majority of the students had a computer in their homes and spent a lot of time on the Internet. Parental control over the amount of time spent on the Internet and the websites that were visited had sometimes limited and contradictory effects on computer usage among the students. A democratic parental attitude was the best approach. Using the computer as a reward or punishment had a negative impact on the children's computer usage patterns. Although parents are confused concerning the benefits and harms of the Internet for their children and not certain how to manage their children's use of the computer and safe navigation of the Internet, a democratic parental attitude appears to be the best approach for reaching the most beneficial computer usage patterns for students.

  7. PENGARUH TANGGUNG JAWAB SOSIAL PERUSAHAAN TERHADAP KUALITAS PENGUNGKAPAN INFORMASI TANGGUNG JAWAB SOSIAL DAN DAMPAKNYA PADA NILAI PERUSAHAAN (Studi Empiris Pada Perusahaan Publik Di Bursa Efek Indonesia)

    OpenAIRE

    Ade Adriani

    2016-01-01

    This  research  was  intended  to  examine  :  (1)  the  effect  of  Corporate  Social Responsibility activities (consisting of social responsibility, product responsibility, labor practices responsibility and environmental responsibility) related to the quality  of  social  responsibility  information  disclosures,  and  (2)  the  effect  of Corporate Social Responsibility activities (consisting of social responsibility, product  responsibility,  labor  practices  responsibility,  environmen...

  8. HUBUNGAN FINANCIAL DISTRESS & MEKANISME GCG TERHADAP PELAPORAN AUDIT PADA PERUSAHAAN PERBANKAN YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2005-2010

    Directory of Open Access Journals (Sweden)

    Mario Pratama Putra Riyanda

    2013-03-01

    Full Text Available This study examines the relation between the composition of financially distressed banks, boards of director Committees and institutional ownership to the likelihood of receiving going concern reports. The composition board of director Committees and institutional ownership represent Good Corporate Governance (GCG mechanism in banks. Financial firms were highly regulated, so we combine BAPEPAM regulation and Altman Z score to identify banks that fit for the financial distress category. For banks experiencing financial distress during 2005-2010, by using logistic regression we find that the greater percentage of financial distress in banks, the smaller the probability the Auditor will issue a going concern report. This empirical study did not support role GCG mechanism on Audit reporting. These results can give us a little sight about implementation of GCG in Indonesia specially for financial firm. The contribution will go to support regulators’ concern about financial reporting, firms behavior (financial and non financial firms in making healthy environment with GCG and the need of balancing proportion in ownership structure in form of the composition board committee and institutional ownership to minimize moral hazard .

  9. Pengaruh Rasio Likuiditas, Rasio Profitabilitas, Rasio Rentabilitas Ekonomi dan Rasio Leverage terhadap Prediksi Financial Distress (Suatu Studi pada Perusahaan Transportasi di Bursa Efek Indonesia)

    OpenAIRE

    Rambe, Erlina Sari

    2016-01-01

    The purpose of this research is to know the influence of liqudity ratio, profitability ratio, economic rentability ratio and leverage ratio either partially or simultaneously toward financial distress prediction in the transportation companies on the Indonesia Stock Exchange. This research is classified as causal research with 16 transportation firms listed in Indonesia Stocks Exchange during 2012 to 2014. This study uses a Altman financial ratio with Z-Score value to prediction of finan...

  10. Pengaruh Resiko, Kualitas Manajemen, Ukuran dan Likuiditas Bank terhadap Capital Adequacy Ratio Bank-Bank yang Terdaftar di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Farah Margaretha

    2011-01-01

    Full Text Available The purposive of this research is to examine the effect of risk, management quality, size and liquidity toward Capital Adequacy Ratio (CAR. This research designed as an explorative research with used purposive sampling method to take the data. Data for this study was collected is publication financial report of banks listed in Indonesian Stock Exchange the period 2003-2008. Statistical analysis by using method of Ordinary Least Square (OLS and Fixed Effect Method. Result of best examination by using method of Fixed Effect Method. The result of research indicated that index risk (risk of asset turnover, management quality, and asset liquidity have the negative impact toward Capital Adequacy Ratio (CAR. While liquidity of liability have the positive impact toward Capital Adequacy Ratio (CAR.

  11. PENGARUH VARIABEL FUNDAMENTAL TERHADAP HARGA SAHAM DAN LABA PER SAHAM (Studi Kasus Pada Industri Properti Yang Go Public di Bursa Efek Jakarta

    Directory of Open Access Journals (Sweden)

    Wahyu Budi Santoso

    2012-05-01

    Full Text Available ABSTRACT This research aims at investigating two issues. First, Whether the several fundamental variables simultantly and partially influence toward the stock price and earning per share on property companies that go public at Jakarta Stock Exchange. Second, Which of several fundamental variables have the most dominant influence either toward the stock price or earning per share. Population used in this research include the entire property companies that go public at Jakarta Stock Exchange with criteria that those companies had the data availibility during 4 periods, those are from the year of 1998 until 2001, from that criteria are obtained about 31 companies where the 24 companies were selected as sample with the simple random sampling technically. The method of analysis is Structural Equation Modelling (SEM. Research results indicate that (1 Simultantly, fundamental indicators have the positive influence toward the stock price (Y1 and earning per share (Y2, these are indicated by positive coefficient for the two variables, however the influence to the earning per share are stronger than to the stock price because its coefficient is bigger than another. In addition, partially there are the significant influence for the variables of earning quality (X7, capital expenditure (X3, gross margin (X4, selling and administration expenses (X5 and inventory (X1 because the p-value are smaller than the 5% significant level, while the variables of account recievable (X2, effective tax rate (X6 and labour force (X9 have not the significant influence. (2 And for the variable of earning quality (X7 has the most dominant influence either to the stock price or earning per share because the p-value is the smallest.   Key Words: Fundamental Analysis, Stock Price, EPS

  12. Analisis Faktor-Faktor Yang Mempengaruhi Bid Ask Spread Pada Masa Sebelum Dan Sesudah Stock Split Di Bursa Efek Indonesia Periode 2008-2013

    OpenAIRE

    Pakpahan, Quitsyah Agnes

    2014-01-01

    Bid Ask Spread is the difference of ask-price and bid-price of shares on the capital market. Bid ask spread is a factor that can influence the investor decision whether hold or sell their shares and make profit from spread of ask price and bid price. This is indicates that the stock liquidity as reflected in the stock price, trading volume, stock return will affect bid ask spread. Bid ask spread will increase if the risk of stock is increase, such as the less liquidity of stock, the higher ri...

  13. PENGARUH KEPEMILIKAN INSTITUSIONAL, UKURAN PERUSAHAAN, PROFITABILITAS DAN RISIKO BISNIS TERHADAP KEBIJAKAN HUTANG PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2008-2012

    Directory of Open Access Journals (Sweden)

    Umi Mardiyati

    2014-04-01

    Full Text Available The purpose of this study is to know the effect of Institutional Ownership, Firm Size, Profitability, and Business Risk on Manufacture Firm Debt Policy Listed in Indonesia Stock Exchange. The sample using purposive sampling. The research model in this study employs panel data analysis with fixed effect approach. The empirical results show that institutional ownership and firm size have positive and significant effect on debt policy. ROA have negative significant effect on debt policy, but business risk have negative and not significant effect on debt policy. Simultaneous test showed that institutional ownership, firm size, profitability, and business risk effect the debt policy.

  14. Pengaruh Mekanisme Good Corporate Governance, Financial Distress terhadap Earning Management dengan Variabel Financial Distress sebagai Mediasi : Studi Empiris pada Perusahaan Pertambangan yang Terdaftar di Bursa Efek Indonesia

    OpenAIRE

    Fathoni, Ahmad Fauzan; Ewanto, Muhammad

    2014-01-01

    This study aims to determine the effect of good corporate governance on Earning Management and Financial Distress on mining companies listed on Indonesia Stock Exchange (BEI ) in the year 2009-2011. Variables tested in this study consists of institutional ownership,managerial ownership, the proportion of audit committee and independent commissioners, earningsmanagement and financial distress.The sample was mining companies listed on the Indonesia Stock Exchange ( IDX years 2009-2011). The sam...

  15. Relative quantification and detection of different types of infectious bursal disease virus in bursa of Fabricius and cloacal swabs using real time RT-PCR SYBR green technology

    DEFF Research Database (Denmark)

    Li, Yiping; Handberg, K.J.; Kabell, Susanne

    2007-01-01

    or F52/70 inoculation were detected as virus positive at day I post inoculation (p.i.). The D78 viral load peaked at day 4 and day 8 p.i., while the DK01 and F52/70 viral load showed relatively high levels at day 2 p.i. In cloacal swabs, viruses detectable were at day 2 p.i. for DK01 and F52/70, day 8...

  16. Analisis Pengaruh Tingkat Profitabilitas dan Harga Saham Terhadap Volume Penjualan Saham Pada Perusahaan Real Estate dan Property yang Terdaftar di Bursa Efek Indonesia

    OpenAIRE

    Matius, Pebri

    2016-01-01

    The formulation of the problem in this research is the extent to which the influence of the level of profitability and share price of the stock on the sales volume Real estate and Property companies listed on the Indonesia Stock Exchange. The purpose of this study is to investigate and analyze the effect of the level of profitability and share price of the stock on the sales volume Real Estate and Property companies listed on the Indonesia Stock Exchange. The independent variable in this stud...

  17. Pengaruh Audit Quality, Audit Tenure, Audit Report Lag, dan Profitabilitas terhadap Opini Audit Going Concern pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia Periode 2010-2013

    OpenAIRE

    Grace N. Rgg, Hermin

    2015-01-01

    The purpose of this research is to analyze the effect of audit quality using proxy auditor industry specialization, audit tenure, audit report lag, and profitability using proxy net profit margin ratio on going concern opinion. Population used in this research is manufacturing companies listed in Indonesian Directory Exchange from 2010-2013. This research uses 20 sample companies achieved using purposive sampling. Data used in this research is secondary data are financial statement and indepe...

  18. MENDETEKSI EARNINGS MANAGEMENT DAN AKUN-AKUN YANG BERPENGARUH (Studi Pada Perusahaan Yang Melakukan Aktivitas Penawaran Saham Perdana Di Bursa Efek Jakarta

    Directory of Open Access Journals (Sweden)

    OTTO - BUDIHARDJO

    2012-05-01

    Full Text Available ABSTRACT Earnings Management (EM is an effort performed by company management as financial report issuer on purpose to influence the readers and stakeholders behavior who rely on financial reports as their primary information source, in accordance with firm managements’ direction.   EM motivations may vary, from remuneration reason, merger and acquisition event, to comply with particular requirement and regulation, to initial public offering (IPO motivation. This study revealed EM effort in IPO event due to management motivation to demonstrate good performance to public before and during such activity. This study took 50 IPO firms listed at Jakarta Stock Exchange (JSX within 1998-2002. EM detection adopted Modified Jones Model as a powerful model to detect EM. Test result proved that EM was occurred on JSX IPO firms as stated by positive discretionary accruals (DA.                  Further study tried to reveal accounts used as EM tools. This study utilized linear regression with DA as fixed variable to indicate EM and predicted accounts on financial reports used as way to do EM as explanatory variables. Such explanatory variables are account receivable, account payable, inventory, accrued liability, accumulated depreciation, expenses (selling and general administrative and other income (expense. Test result showed that only two variables statistically significant to dependent variable, i.e. DA, they were account receivable and account payable. This result supports a study by Marquardt and Wiedman (2002 who found that EM during IPO activity was influenced by account receivable in positive direction. However, this study does not support Wiedyaningdyah (2001 who concluded IPO activity in JSX during 1994-1997 was significantly influenced by liability (leverage. This study recommends investors or any other parties who rely on firm financial report during IPO activity on JSX to behave more conservative on net income as reported by related firms and considers account receivable and account payable as accounts need to be reviewed prior to any economical decision making related to the financial reports. Key words: Earnings Management, Discretionary Accruals, Initial Public Offerings (IPO.

  19. PENGARUH PROFITABILITAS, SOLVABILITAS, REPUTASI AUDITOR, UKURAN PERUSAHAAN, KANDUNGAN LABA, DAN JENIS INDUSTRI PADA KETIDAKTEPATWAKTUAN PUBLIKASI LAPORAN KEUANGAN DI PT BURSA EFEK INDONESIA PERIODE 2007 - 2009

    Directory of Open Access Journals (Sweden)

    MADE GEDE WIRAKUSUMA

    2011-07-01

    Full Text Available The usefulness of financial report would decrease if it is not timely reported. The purpose of this study is to examine the impact of profitability, solvency, auditor reputation, company size, earnings content, and industry type on late publication of financial report on Indonesia Stock Market during period of 2007-2009. The hypotheses are tested using multiple regression technique. The results show that auditor reputation and company size significantly affect the late publication of financial reports of companies listed on Indonesia Stock Market during 2007-2009. Other variables, i.e profitability, solvency, and earnings information content do not affect the late publication. The control variable, industry type, also does not have any impact on the late financial report publication of the listed companies.

  20. Pengaruh Right Issue Terhadap Volume Perdagangan Saham Dan Return Saham Perusahaan Yang Terdaftar Di Bursa Efek Indonesia Tahun 2010-2013

    OpenAIRE

    Kristy, Herico

    2015-01-01

    The purpose of this study is to find partially the empirical evidence about the difference of stock trading volume and stock return of listed companies before and after right issue in Indonesia Stock Exchange. This study is conducted by using even study. Data used in this study is stock trading volume and stock return data in five days before and after right issue that obtained from Indonesia Stock Exchange publication, reference books, internet, and scie...

  1. Analisis Kebangkrutan Perusahaan dengan Menggunakan Metode Z Score (Studi Kasus pada Industri Consumer Goods di Bursa Efek Jakarta Periode 1997 – 2000

    Directory of Open Access Journals (Sweden)

    Nuning Kriesnawati

    2016-02-01

    Full Text Available This study aimed to analyze bankruptcy using the Z score. Research done in the consumer goods industry listed in Jakarta Stock Exchange 1997-2000 period. The results found that in 2000 the value of Z score companies has decreased, this is possible because the value of the variable X3 and X4 has decreased, but in 2001 the value of Z score Integration again experienced an increase, although not as high as in 1999, this means that the company can improve its performance. PT Mandom value of Z score indicates that the company is in a good condition or not bankruptcy. Z score value of the company from 1997 to 2001 continues to increase, it suggests that good corporate performance which proved that despite the crisis the company was still able to survive even continue to increase. Analysis of the bankruptcy of PT Unilever shows that the company is in a good condition. As in PT Mandom, the company is also not affected by the crisis. Z score value of the company from 1997 to 2001 have increased constantly, this indicates that the performance is good. Analysis of the bankruptcy of the PT Procter and Gamble shows that the company is in conditions that are less stable, this is indicated by the value of Z score in 1997 shows that the company is in the condition of the gray area, in 1998 based on assessment standards of bankruptcy, the company in 1998 experienced bankruptcy, in 1999 the company experienced a slight improvement from the beginning in a state of bankruptcy changes on the condition of the gray area, in 2000 the company was in good condition or not bankrupt, this is possible because the company sells most of its fixed assets in order to operate properly. However, in 2001 the company back on the condition of the gray area, it is because the value X2 to X5 has decreased.

  2. Pengaruh Pertumbuhan Penjualan, Likuiditas, Profitabilitas, dan Working Capital Terhadap Struktur Modal Pada Perusahaan Otomotif Dan Komponen yang Terdaftar Di Bursa Efek Indonesia (BEI) Tahun 2010-2013

    OpenAIRE

    Faisal, Aldi

    2015-01-01

    This study aimed to test whether the Growth of Sales, Liquidity, Profitability, and Working Capital has the effect of partially or simultaneously to Capital Stock in automotive and components companies listed in Indonesia Stock Exchange period 2010 to 2013. This research is a type of causal research, which used data from a population of 16 automotive and components companies listed in Indonesia Stock Exchange. The sampling method used in this research is purposive sampling and acquired co...

  3. PERBANDINGAN KINERJA KEUANGAN PERUSAHAAN SEBELUM DAN SESUDAH MERGER DAN AKUISISI (PADA PERUSAHAAN PENGAKUISISI YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2004-2006

    Directory of Open Access Journals (Sweden)

    Hamidah Hamidah

    2013-04-01

    Full Text Available The purpose of this study was to examine the differences in the financial performance of the acquirer pre and post mergers and acquisitions. Financial performance is measured with some ratios, Current Ratio (CR, Total Assets Turnover (TATO, Debt Ratio (DR, Return on Assets (ROA, and Price Earnings Ratio (PER. Population of this study included all public company which conducted merger and acquisition(M & A activity in the period 2004-2006. The samples were 10 companies that were taken by purposive sampling method. Analysis of the data used to test hypotheses using Paired Sample t-Test. Empirical results shows that there are no significant difference for DR and TATO in testing 1 year before and 1 year after M & A up to 1 year before and 5 years after M & A. However, CR shows significant difference in test 1 year before with 2, 4, and 5 years after M & A; ROA shows significant difference in test 1 year before with 4 years after M & A; then PER shows significant difference in test 1 year before with 3 years after M & A.

  4. Pengaruh Keputusan Investasi, Keputusan Pendanaan Terhadap Nilai Perusahaan Dengan Growth Sebagai Variabel Intervening pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia Periode 2010-2014

    OpenAIRE

    Firnando, Sandi Agung

    2017-01-01

    The problem of this research are the extent to which the effect of investment decision which is measured by Price Earning Ratio (PER) toward growth; the extent to which the effect of financing decision which is measured by Debt to Equity Ratio (DER) toward growth; the extent to which the effect of investment decision which is measured by Price Earning Ratio (PER) toward firm value which is measured by Price to Book Value (PBV); the extent to which the effect of financing decision which is mea...

  5. Penerapan IFRS Dan Pengaruhnya terhadap Keterlambatan Penyampaian Laporan Keuangan: Studi Empiris Perusahana Manufaktur di Bursa Efek Indonesia Periode Tahun 2008-2010

    Directory of Open Access Journals (Sweden)

    Stepvanny Margaretta

    2012-11-01

    Full Text Available There are several factors that affect the company's delay in submitting the financial statements are often referred to as Audit Delay, among others IFRS (International Financial Reporting Standards, firm size, profitability, size public accounting firm, audit opinion, and complexity. One factor that is quite prominent is the application of IFRS that have not been uniform across all companies in Indonesia. It could also lead to Audit Delay. Firm size theoretically means companies bigger scale required to submit financial reports on time. As for profitability, KAP size, and complexity of the audit opinion is also decent enough to be considered as one of the influential factors on Audit Delay. The results of this study indicate that the application of IFRS, profitability, size KAP, audit opinion, and complexity does not have a significant impact on the delay for submission of financial statements. Finaly, a factor that leads to significant effect of time delay submission of financial statements is the size of the company.

  6. Role of toll like receptors in bacterial and viral diseases – A ...

    African Journals Online (AJOL)

    Avishek Das

    2017-05-20

    May 20, 2017 ... Cellular Immunology Laboratory, Department of Zoology, University of North ... Background: Toll like receptors are key-receptors of the innate immune ...... Triggering TLR7 in mice induces immune activation and lymphoid.

  7. True bursal pigmented villonodular synovitis

    International Nuclear Information System (INIS)

    Abdelwahab, Ibrahim Fikry; Kenan, Samuel; Steiner, German C.; Abdul-Quader, Mohammed

    2002-01-01

    We describe two cases of pigmented villonodular synovitis affecting true bursae. This study was also designed to discuss the term ''pigmented villonodular bursitis'', not confined to true synovial bursae, sometimes creating misunderstanding. (orig.)

  8. True bursal pigmented villonodular synovitis

    Energy Technology Data Exchange (ETDEWEB)

    Abdelwahab, Ibrahim Fikry [Department of Radiology, New York Methodist Hospital, Affiliated with New York Hospital-Cornell Medical Center, Brooklyn, NY (United States); Kenan, Samuel [Department of Orthopedics, New York University Medical Center, NY (United States); Steiner, German C. [Department of Pathology, Hospital for Joint Diseases/Orthopedic Institute, New York, NY (United States); Abdul-Quader, Mohammed [Department of Radiology, New York Presbyterian Hospital, Columbia University, New York, NY (United States)

    2002-06-01

    We describe two cases of pigmented villonodular synovitis affecting true bursae. This study was also designed to discuss the term ''pigmented villonodular bursitis'', not confined to true synovial bursae, sometimes creating misunderstanding. (orig.)

  9. 76 FR 80673 - Registration of Foreign Boards of Trade

    Science.gov (United States)

    2011-12-23

    ... Exchange, Inc. (NGX), and Bursa Malaysia Derivatives Exchange (Bursa Derivatives). A direct access no..., fitness review, or qualification of persons through whom customer orders are solicited and accepted; (ii...

  10. Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells.

    Directory of Open Access Journals (Sweden)

    Besma Aouar

    Full Text Available Crosslinking of regulatory immunoreceptors (RR, such as BDCA-2 (CD303 or ILT7 (CD85g, of plasmacytoid dendritic cells (pDCs efficiently suppresses production of type-I interferon (IFN-α/β and other cytokines in response to Toll-like receptor (TLR 7/9 ligands. This cytokine-inhibitory pathway is mediated by spleen tyrosine kinase (Syk associated with the ITAM-containing adapter of RR. Here we demonstrate by pharmacological targeting of Syk that in addition to the negative regulation of TLR7/9 signaling via RR, Syk also positively regulates the TLR7/9 pathway in human pDCs. Novel highly specific Syk inhibitor AB8779 suppressed IFN-α, TNF-α and IL-6 production induced by TLR7/9 agonists in primary pDCs and in the pDC cell line GEN2.2. Triggering of TLR9 or RR signaling induced a differential kinetics of phosphorylation at Y352 and Y525/526 of Syk and a differential sensitivity to AB8779. Consistent with the different roles of Syk in TLR7/9 and RR signaling, a concentration of AB8779 insufficient to block TLR7/9 signaling still released the block of IFN-α production triggered via the RR pathway, including that induced by hepatitis B and C viruses. Thus, pharmacological targeting of Syk partially restored the main pDC function-IFN-α production. Opposing roles of Syk in TLR7/9 and RR pathways may regulate the innate immune response to weaken inflammation reaction.

  11. Infectious pancreatic necrosis the trout farmers' dilemma

    Science.gov (United States)

    Parisot, T.J.

    1965-01-01

    Induction of the innate immune pathways is critical for early anti-viral defense but there is limited understanding of how teleost fish recognize viral molecules and activate these pathways. In mammals, Toll-like receptors (TLR) 7 and 8 bind single-stranded RNA of viral origin and are activated by synthetic anti-viral imidazoquinoline compounds. Herein, we identify and describe the rainbow trout (Oncorhynchus mykiss) TLR7 and TLR8 gene orthologs and their mRNA expression. Two TLR7/8 loci were identified from a rainbow trout bacterial artificial chromosome (BAC) library using DNA fingerprinting and genetic linkage analyses. Direct sequencing of two representative BACs revealed intact omTLR7and omTLR8a1 open reading frames (ORFs) located on chromosome 3 and a second locus on chromosome 22 that contains an omTLR8a2 ORF and a putative TLR7pseudogene. We used the omTLR8a1/2 nomenclature for the two trout TLR8 genes as phylogenetic analysis revealed that they and all the other teleost TLR8 genes sequenced to date are similar to the zebrafish TLR8a, but are distinct from the zebrafish TLR8b. The duplicated trout loci exhibit conserved synteny with other fish genomes extending beyond the tandem of TLR7/8 genes. The trout TLR7 and 8a1/2 genes are composed of a single large exon similar to all other described TLR7/8 genes. The omTLR7 ORF is predicted to encode a 1049 amino acid (aa) protein with 84% similarity to the Fugu TLR7and a conserved pattern of predicted leucine-rich repeats (LRR). The omTLR8a1 andomTLR8a2 are predicted to encode 1035- and 1034-aa proteins, respectively, and have 86% similarity to each other. omTLR8a1 is likely the ortholog of the only Atlantic salmonTLR8 gene described to date as they have 95% aa sequence similarity. The tissue expression profiles of omTLR7, omTLR8a1 and omTLR8a2 in healthy trout were highest in spleen tissue followed by anterior and then posterior kidney tissues. Rainbow trout anterior kidney leukocytes produced elevated levels of

  12. Pengaruh Profitabilitas Terhadap Intial Return Dilihat Dari Aspek Cash Basis Dan Accrual Basis (Studi Pada Perusahaan Yang Melakukan Initial Public Offering (Ipo Di Bursa Efek Indonesia Periode Januari 2011 – Agustus 2015

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    Miranti Dewi Febriani

    2017-07-01

    Full Text Available The study aims to examine the effect of profitability on Initial Return based on cash basis and accrual basis. The population in this study is companies performing IPO in period of January 2011 – Augustus 2015 as many as 111 companies and are adjusted to several criteria in order to get as many as 70 companies for model 1, 72 companies for model 2, and 53 companies for model 3. It uses simple regression analysis technique assisted by Gretl Software. Interstingly, only ROE affect Initial Return and model 1 has highest R2.

  13. Analisis Perbandingan Model Altman, Springate, Ohlson, Fulmer, CA-Score dan Zmijewski dalam Memprediksi Financial Distress (Studi Empiris pada Perusahaan Food And Beverages yang Terdaftar di Bursa Efek Indonesia Periode 2010-2012)

    OpenAIRE

    DP, Emrinaldi Nur; Wulandari, Veronita

    2014-01-01

    This study purpose to determine wheter there are differences among Altman model, Springate model, Ohlson model, Fulmer model, CA-Score model and Zmijewski model to predict financial distress, and to find out which the Financial Distress prediction model has the most excellent implementation on food and beverages company in Indonesia. Comparison of those six models were made by analyzing the accuracy of each model, by using the real condition of a companys net income.The data used in the form ...

  14. Analisis Metode Capital Asset Pricing Model Dalam Upaya Pengambilan Keputusan Terhadap Investasi Saham (Studi Pada Saham-saham Perusahaan Sektor Properti Dan Real Estate Di Bursa Efek Indonesia (Bei) Periode 2010 – 2012)

    OpenAIRE

    Nasuha, Rizky

    2013-01-01

    The research was motivated by the development of the business world, where companies rely heavily on investment. Before investing, stock investment in this case, it is necessary to consider the possibilities that will be faced by investors. One method used to assess investment decisions is the CAPM (Capital Asset Pricing Model). This study aims to analyze the CAPM method related to stock investment decisions. Types of research used in this research is descriptive research with quantitative ap...

  15. Penerapan Metode Capital Asset Pricing Model (Capm) Untuk Penetapan Kelompok Saham-saham Efisien (Studi Pada Perusahaan Industri Barang Konsumsi Yang Terdaftar Di Bursa Efek Indonesia Periode 2011 -2013)

    OpenAIRE

    Kurniawan, Fauzi Adi

    2015-01-01

    This research purpose to determine the performance of stock based on the return and risk to determine the group of efficient stocks and inefficient stock by the use of methods of Capital Asset Pricing Model (CAPM). The sample used in this study were 15 company shares consumer goods industry sector listed in Indonesia Stock Exchange 2011-2013 that selected based on certain criteria. The analysis showed there is 1 stock companies included in the group of inefficient stock (overvalued) and 14 st...

  16. Pengaruh Proporsi Dewan Komisaris, Ukuran Perusahaan, Leverage, Ukuran Kantor Auditor Publik, dan Frekuensi Rapat Dewan terhadap Pembentukan Risk Management Committee pada Perusahaan Perbankan yang terdaftar di Bursa Efek Indonesia

    OpenAIRE

    Yahya, Ilham

    2016-01-01

    Risk Management Committee is a committee established by the board of directors together with the Audit Committee, Remuneration Committee and Nomination Committee. RMC in the company responsible for determining risk management strategies, evaluate risk management operations, assessing financial reporting and ensuring the organization runs in accordance with the laws and regulations. The population in this study is a banking company that is listed on the Indonesia Stock Exchange as many as 4...

  17. PENGARUH EARNING PER SHARE (EPS, DEBT TO EQUITY RATIO (DER DAN RETURN ON EQUITY (ROE TERHADAP HARGA SAHAM (Studi Empiris Pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia Tahun 2007-2011

    Directory of Open Access Journals (Sweden)

    Arum Desmawati Murni Mussalamah

    2016-08-01

    Full Text Available The aim of this study is to test the effect of Earning Per Share (EPS, Debt to Equity Ratio (DER, and Return On Equity (ROE to stock price. This study was chosen because there were still differences between one study and another. There was also distinct condition between theory and the reality. This study was conducted using secondary data. Samples were taken using purposive sampling technic. From one hundred and twenty manufacture company, sixty were chosen due to its complete financial report from 2007-2011. The analysis methods used for this study is double linier regression analysis. Using regression analysis,it was showed that Earning Per Share (EPS had a positive and significant effect, Debt to Equity Ratio (DER had a negative dan significant effect, meanwhile Return On Equity (ROE had a positive and significant effect to stock price. Taken together, it was showed that 90,4% variation and stock price could be described by EPS, DER and ROE variable.The rest (9,6% could be described by other variables outside the model.

  18. Perbandingan Analisis Prediksi Kebangkrutan Menggunakan Model Altman Pertama, Altman Revisi, dan Altman Modifikasi dengan Ukuran dan Umur Perusahaan sebagai Variabel Penjelas (Studi Pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Ayu Suci Ramadhani

    2011-03-01

    Full Text Available This study observes the bankruptcy prediction models introduced by Altman; the First Altman model, the Revised Altman model, and the Modified Altman model to predict bankruptcy for manufacturing companies listed in the Indonesian Stock Exchange. The research was conducted for forty-two manufacturing companies that matched criteria in the selection of the sample over the years 2004-2007 based on published data for the same period. To accommodate various Almant models, the data was then calculated based on financial ratio and the data have been processed further to find the bancruptcy index as suggested by the models. The results of the three models are then compared with the use of company’s age and size as descriptive information to predict the company’s bankruptcy potential. The result of comparative data in bankruptcy prediction is that; the first Altman provides the highest percentage in predicting the bankruptcy. The research also found that the company categorized under small groups and under the age of 30 were likely to go bankcrupt in compare to the other groups. Keywords:    financial distress, bankruptcy Index, bankruptcy prediction model, size of the company, age of the company.

  19. Analisis Portofolio Menggunakan Capital Asset Pricing Model (Capm) Untuk Penetapan Kelompok Saham-saham Efisien (Studi Pada Seluruh Saham Perusahaan Yang Terdaftar Di Bursa Efek Indonesia Tahun 2010-2012)

    OpenAIRE

    Elvira, Nasika

    2014-01-01

    The objective of research is to explain the analysis against the performance of stocks of the companies listed in Indonesia Stock Exchange based on their return and risk, and to explain the analysis of the determination of efficient stock group based on Capital Asset Pricing Model (CAPM) over the stocks of the companies listed in Indonesia Stock Exchange for portfolio establishment in period 2010-2012. The USAge of Capital Asset Pricing Model (CAPM) in this research is that CAPM method can ex...

  20. Pengaruh Ukuran Perusahaan, Profitability, Dan Debt Equity Ratio Terhadap Ketepatan Waktu Pelaporan Keuangan (Studi Pada Perusahaan Sektor Industri Food And Beverages Dan Sektor Industri Tekstile Yang Terdaftar Di Bursa Efek Indonesia

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    Ine Aprianti

    2017-07-01

    Full Text Available The research objective was to show how the development of the growth of company size, profitability and debt to equity ratio of the timeliness of financial reporting. This study uses deskiptif research and verification. With data analysis techniques using parametric statistics. The population in this study amounted to 43 companies sector of food and beverages industry and textile industry sectors in the study period of 2006 to 2008. That was then acquired 15 companies in the sample using purposive sampling method of sample collection techniques with particular consideration.The data used in this research is secondary data derived from the Corner Exchange ITB and www.idx.co.id official website that the company's financial statement data sectors of food and beverages industry and textile industry sectors listed on the Stock Exchange. The results of multiple linear regression t test showed that the variables of profitability and debt to equity affect the timeliness of financial reporting, while the size of the company does not affect the timeliness of financial reporting. In the F test shows that together variables company size, profitability and debt to equity affect the timeliness of financial reporting. Keywords: debt to equity ratio, timeliness, firm size, profitability, financial reporting.

  1. Differential expression of viral PAMP receptors mRNA in peripheral blood of patients with chronic hepatitis C infection

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    Riñón Marta

    2007-11-01

    Full Text Available Abstract Background Pathogen-associated molecular patterns (PAMP receptors play a key role in the early host response to viruses. In this work, we determined mRNA levels of two members of the Toll-like Receptors family, (TLR3 and TLR7 and the helicase RIG-I, all of three recognizing viral RNA products, in peripheral blood of healthy donors and hepatitis C virus (HCV patients, to observe if their transcripts are altered in this disease. Methods IFN-α, TLR3, TLR7 and RIG-I levels in peripheral blood from healthy controls (n = 18 and chronic HCV patients (n = 18 were quantified by real-time polymerase chain reaction. Results Our results show that IFN-α, TLR3, TLR7 and RIG-I mRNA levels are significantly down-regulated in patients with chronic HCV infection when compared with healthy controls. We also found that the measured levels of TLR3 and TLR7, but not RIG-I, correlated significantly with those of IFN-α Conclusion Monitoring the expression of RNA-sensing receptors like TLR3, TLR7 and RIG-I during the different clinical stages of infection could bring a new source of data about the prognosis of disease.

  2. Anti-tumor Activity of Toll-Like Receptor 7 Agonists

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    Huju Chi

    2017-05-01

    Full Text Available Toll-like receptors (TLRs are a class of pattern recognition receptors that play a bridging role in innate immunity and adaptive immunity. The activated TLRs not only induce inflammatory responses, but also elicit the development of antigen specific immunity. TLR7, a member of TLR family, is an intracellular receptor expressed on the membrane of endosomes. TLR7 can be triggered not only by ssRNA during viral infections, but also by immune modifiers that share a similar structure to nucleosides. Its powerful immune stimulatory action can be potentially used in the anti-tumor therapy. This article reviewed the anti-tumor activity and mechanism of TLR7 agonists that are frequently applied in preclinical and clinical investigations, and mainly focused on small synthetic molecules, including imiquimod, resiquimod, gardiquimod, and 852A, etc.

  3. Differential induction of Toll-like receptors & type 1 interferons by Sabin attenuated & wild type 1 polioviruses in human neuronal cells.

    Science.gov (United States)

    Mohanty, Madhu C; Deshpande, Jagadish M

    2013-01-01

    Polioviruses are the causative agent of paralytic poliomyelitis. Attenuated polioviruses (Sabin oral poliovirus vaccine strains) do not replicate efficiently in neurons as compared to the wild type polioviruses and therefore do not cause disease. This study was aimed to investigate the differential host immune response to wild type 1 poliovirus (wild PV) and Sabin attenuated type 1 poliovirus (Sabin PV) in cultured human neuronal cells. By using flow cytometry and real time PCR methods we examined host innate immune responses and compared the role of toll like receptors (TLRs) and cytoplasmic RNA helicases in cultured human neuronal cells (SK-N-SH) infected with Sabin PV and wild PV. Human neuronal cells expressed very low levels of TLRs constitutively. Sabin PV infection induced significantly higher expression of TLR3, TLR7 and melanoma differentiation-associated protein-5 (MDA-5) m-RNA in neuronal cells at the beginning of infection (up to 4 h) as compared to wild PV. Further, Sabin PV also induced the expression of interferon α/β at early time point of infection. The induced expression of IFN α/β gene by Sabin PV in neuronal cells could be suppressed by inhibiting TLR7. Neuronal cell innate immune response to Sabin and wild polioviruses differ significantly for TLR3, TLR7, MDA5 and type 1 interferons. Effects of TLR7 activation and interferon production and Sabin virus replication in neuronal cells need to be actively investigated in future studies.

  4. Differential induction of Toll-like receptors & type 1 interferons by Sabin attenuated & wild type 1 polioviruses in human neuronal cells

    Directory of Open Access Journals (Sweden)

    Madhu C Mohanty

    2013-01-01

    Full Text Available Background & objectives: Polioviruses are the causative agent of paralytic poliomyelitis. Attenuated polioviruses (Sabin oral poliovirus vaccine strains do not replicate efficiently in neurons as compared to the wild type polioviruses and therefore do not cause disease. This study was aimed to investigate the differential host immune response to wild type 1 poliovirus (wild PV and Sabin attenuated type 1 poliovirus (Sabin PV in cultured human neuronal cells. Methods: By using flow cytometry and real time PCR methods we examined host innate immune responses and compared the role of toll like receptors (TLRs and cytoplasmic RNA helicases in cultured human neuronal cells (SK-N-SH infected with Sabin PV and wild PV. Results: Human neuronal cells expressed very low levels of TLRs constitutively. Sabin PV infection induced significantly higher expression of TLR3, TLR7 and melanoma differentiation-associated protein-5 (MDA-5 m-RNA in neuronal cells at the beginning of infection (up to 4 h as compared to wild PV. Further, Sabin PV also induced the expression of interferon α/β at early time point of infection. The induced expression of IFN α/β gene by Sabin PV in neuronal cells could be suppressed by inhibiting TLR7. Interpretation & conclusions: Neuronal cell innate immune response to Sabin and wild polioviruses differ significantly for TLR3, TLR7, MDA5 and type 1 interferons. Effects of TLR7 activation and interferon production and Sabin virus replication in neuronal cells need to be actively investigated in future studies.

  5. Toll-like receptor 7-mediated enhancement of contextual fear memory in mice.

    Science.gov (United States)

    Kubo, Yasunori; Yanagawa, Yoshiki; Matsumoto, Machiko; Hiraide, Sachiko; Kobayashi, Masanobu; Togashi, Hiroko

    2012-10-01

    Toll-like receptor (TLR) 7 recognizes viral single-stranded RNA and triggers production of the type I interferons (IFNs) IFN-α and IFN-β. Imiquimod, a synthetic TLR7 ligand, induces production of type I IFNs and is used clinically as an antiviral and antitumor drug. In the present study, we examined the effect of imiquimod on conditioned and innate fear behaviors in mice. Imiquimod was administered 2, 4, or 15 h before contextual fear conditioning. Imiquimod treatment 4 or 15 h before fear conditioning significantly enhanced context-dependent freezing behavior. This imiquimod-induced enhancement of fear-related behaviors was observed 120 h after fear conditioning. In contrast, imiquimod failed to enhance context-dependent freezing behavior in TLR7 knockout mice. Imiquimod had no significant effect on pain threshold or on innate fear-related behavior, as measured by the elevated plus-maze. The levels of type I IFN mRNA in the brain were significantly increased at 2 h after imiquimod treatment. Imiquimod also increased interleukin (IL)-1β mRNA expression in the brain at 4 h following administration, while mRNA expression of F4/80, a macrophage marker, was unaffected by imiquimod treatment. Our findings suggest that TLR7-mediated signaling enhances contextual fear memory in mice, possibly by inducing the expression of type I IFNs and IL-1β in the brain. Copyright © 2012 Elsevier Inc. All rights reserved.

  6. Development of immune memory to glial brain tumours after tumour regression induced by immunotherapeutic Toll-like receptor 7/8 activation

    NARCIS (Netherlands)

    Stathopoulos, A.; Pretto, C.; Devilliers, L.; Hofman, F.M.; Kruse, C.A.; Jadus, M.; Chen, T.C.; Schijns, V.E.J.C.

    2012-01-01

    The efficacy of immunotherapeutic TLR7/8 activation by resiquimod (R848) was evaluated in vivo, in the CNS-1 rat glioma model syngeneic to Lewis rats. The immune treatment was compared with cytotoxic cyclophosphamide chemotherapy, and as well, was compared with the combination cytotoxic and

  7. in Egyptian patients with chronic hepatitis C Infection and ...

    African Journals Online (AJOL)

    Tahany A. Abdel-Raouf

    2014-08-28

    Aug 28, 2014 ... correlating it with both serum levels of IFN-a and viral load. Results: The .... samples was then determined by comparing the optical density of the samples ... TLR7, a sensor for viral ssRNA, plays a significant role in anti HCV ...

  8. Toll like receptor7 polymorphisms in relation to disease susceptibility and progression in Chinese patients with chronic HBV infection.

    Science.gov (United States)

    Zhu, Junping; Zhang, Tong; Cao, Lina; Li, Aixin; Zheng, Kai; Zhang, Nan; Su, Bin; Chen, Zhiyun; Chen, Ning; Wu, Hao; He, Qiushui

    2017-09-29

    Toll-like receptors (TLRs) play a key role in innate and adaptive immunity, protecting the host from viral pathogens. We studied the effect of TLR7 polymorphisms on disease susceptibility and progression of chronic hepatitis B (CHB) infection in Chinese adults. Blood samples were taken from 612 patients with confirmed CHB, hepatitis B virus (HBV)-related liver cirrhosis (LC) or hepatocellular carcinoma (HCC) and 293 controls. TLR7 polymorphisms (rs179010-C > T, rs2074109-T > C, and rs179009-A > G) were analyzed by PCR-based sequencing. A significantly higher frequency of TLR7 rs179010 C allele was found in male CHB patients than in controls (74.8% vs 59.5%, P = 0.002). The frequency of rs179009 G allele was markedly increased with disease progression when male patients with CHB, LC and HCC were compared (P = 0.012). The haplotype CTA was significantly associated with an increased susceptibility to CHB among male patients (P = 0.000). Frequency of the haplotype CTG was higher in male patients with HCC than CHB (P = 0.005). No such differences in these allele frequencies were found between female patients and controls. Our results indicated that TLR7 polymorphisms play an important role in disease susceptibility and the progression of CHB infections in Chinese adults, and may partly explain the high incidence of HBV related diseases in Chinese men.

  9. TOLL-LIKE RECEPTOR 7 GENE Gln11Leu MISSENSEMUTATION AND SUSCEPTIBILITY TO PSORIASIS

    Directory of Open Access Journals (Sweden)

    E. S. Galimova

    2017-01-01

    Full Text Available Toll-like receptor (TLR are responsible for recognizing various molecular patterns associated with pathogens. Their expression have been detected in skin cells such as keratinocytes and melanocytes. Numerous experimental studies demonstrate the key role of TLRs in the pathogenesis of immune diseases, including psoriasis. The objective of this study is to analyze the associations of polymorphisms in TLR7 gene and the risk of psoriasis development. DNA samples were collected from 138 patients with psoriasis and 317 healthy controls. Genotyping of rs179003, rs179008, rs179020, rs850632, rs12013728 polymorphic loci in TLR7 gene was performed using the SNPlex™method (AB, USA. SNP in the TLR7 gene rs179008 (Gln11Leu was associated with psoriasis in entire psoriasis, late onset and sporadic subgroups (Рс = 0.0065, OR = 1.95; Рс = 0.0004, OR = 2.50; Рс = 0.0078, OR = 2.2, respectively. In conclusion, this study is the first to identify genetic variants of the TLR7 gene significantly associated with psoriasis. 

  10. Results of a Phase 1 Dose Escalation Study of Intravesical TMX-101 in Patients with Nonmuscle Invasive Bladder Cancer

    NARCIS (Netherlands)

    Falke, Johannes; Lammers, Rianne J. M.; Arentsen, Harm C.; Ravic, Miroslav; Pozzi, Raffaella; Cornel, Erik B.; Vergunst, Henk; de Reijke, Theo M.; Witjes, J. Alfred

    2013-01-01

    Purpose: Imiquimod, a toll like receptor 7 (TLR-7) agonist, is effective as a topical treatment for skin malignancies. TMX-101 is a liquid formulation of imiquimod. In this study we establish a safety profile of TMX-101 in patients with nonmuscle invasive bladder cancer. Materials and Methods: We

  11. Results of a phase 1 dose escalation study of intravesical TMX-101 in patients with nonmuscle invasive bladder cancer

    NARCIS (Netherlands)

    Falke, J.; Lammers, R.; Arentsen, H.C.; Ravic, M.; Pozzi, R.; Cornel, E.B.; Vergunst, H.; Reijke, T.M. de; Witjes, J.A.

    2013-01-01

    PURPOSE: Imiquimod, a toll like receptor 7 (TLR-7) agonist, is effective as a topical treatment for skin malignancies. TMX-101 is a liquid formulation of imiquimod. In this study we establish a safety profile of TMX-101 in patients with nonmuscle invasive bladder cancer. MATERIALS AND METHODS: We

  12. TOLL-LIKE RECEPTOR 7 GENE Gln11Leu MISSENSEMUTATION AND SUSCEPTIBILITY TO PSORIASIS

    Directory of Open Access Journals (Sweden)

    E. S. Galimova

    2017-01-01

    Full Text Available Toll-like receptor (TLR are responsible for recognizing various molecular patterns associated with pathogens. Their expression have been detected in skin cells such as keratinocytes and melanocytes. Numerous experimental studies demonstrate the key role of TLRs in the pathogenesis of immune diseases, including psoriasis. The objective of this study is to analyze the associations of polymorphisms in TLR7 gene and the risk of psoriasis development. DNA samples were collected from 138 patients with psoriasis and 317 healthy controls. Genotyping of rs179003, rs179008, rs179020, rs850632, rs12013728 polymorphic loci in TLR7 gene was performed using the SNPlex™method (AB, USA. SNP in the TLR7 gene rs179008 (Gln11Leu was associated with psoriasis in entire psoriasis, late onset and sporadic subgroups (Рс = 0.0065, OR = 1.95; Рс = 0.0004, OR = 2.50; Рс = 0.0078, OR = 2.2, respectively. In conclusion, this study is the first to identify genetic variants of the TLR7 gene significantly associated with psoriasis.

  13. Detection of Infectious Bursal Disease Virus (IBDV) in naturally ...

    African Journals Online (AJOL)

    The Reverse Transcription - Polymerase Chain Reaction (RT-PCR) was used for the identification of Infectious bursal disease virus (IBDV). The technique was applied on bursa of Fabricius of infected chicken. Some of these bursae have been kept in the freezer for 16years under conditions of regular electric power ...

  14. Small mammals from Sima de los Huesos.

    Science.gov (United States)

    Cuenca-Bescós, G; Laplana Conesa, C; Canudo, J I; Arsuaga, J L

    1997-01-01

    A small collection of rodents from Sima de los Huesos helps to clarify the stratigraphic position of this famous human locality. The presence of Allocricetus bursae and Pliomys lenki relictus and the size of A. bursae, Apodemus sylvaticus and Eliomys quercinus suggest a Middle Pleistocene age (Saalian) to the Clays where humans have been found.

  15. Appearance of the weight-bearing lateral radiograph in retrocalcaneal bursitis

    NARCIS (Netherlands)

    van Sterkenburg, M.N.; Muller, B.; Maas, M.; Sierevelt, I.N.; van Dijk, C.N.

    2010-01-01

    Background and purpose A retrocalcaneal bursitis is caused by repetitive impingement of the bursa between the Achilles tendon and the posterosuperior calcaneus. The bursa is situated in the posteroinferior corner of Kager's triangle (retrocalcaneal recess), which is a radiolucency with sharp borders

  16. Anti-WASP intrabodies inhibit inflammatory responses induced by Toll-like receptors 3, 7, and 9, in macrophages

    Energy Technology Data Exchange (ETDEWEB)

    Sakuma, Chisato [Animal Immune and Cell Biology Research Unit, National Institute of Agrobiological Sciences, 1-2 Ohwashi, Tsukuba, Ibaraki, 305-8634 (Japan); Sato, Mitsuru, E-mail: mitsuru.sato@affrc.go.jp [Animal Immune and Cell Biology Research Unit, National Institute of Agrobiological Sciences, 1-2 Ohwashi, Tsukuba, Ibaraki, 305-8634 (Japan); Oshima, Takuma [Department of Biological Science and Technology, Graduate School of Faculty of Industrial Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510 (Japan); Takenouchi, Takato [Animal Immune and Cell Biology Research Unit, National Institute of Agrobiological Sciences, 1-2 Ohwashi, Tsukuba, Ibaraki, 305-8634 (Japan); Chiba, Joe [Department of Biological Science and Technology, Graduate School of Faculty of Industrial Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510 (Japan); Kitani, Hiroshi [Animal Immune and Cell Biology Research Unit, National Institute of Agrobiological Sciences, 1-2 Ohwashi, Tsukuba, Ibaraki, 305-8634 (Japan)

    2015-02-27

    Wiskott-Aldrich syndrome protein (WASP) is an adaptor molecule in immune cells. Recently, we showed that the WASP N-terminal domain interacted with the SH3 domain of Bruton's tyrosine kinase (Btk), and that the complex formed by WASP and Btk was important for TLR2 and TLR4 signaling in macrophages. Several other studies have shown that Btk played important roles in modulating innate immune responses through TLRs in immune cells. Here, we evaluated the significance of the interaction between WASP and Btk in TLR3, TLR7, and TLR9 signaling. We established bone marrow–derived macrophage cell lines from transgenic (Tg) mice that expressed intracellular antibodies (intrabodies) that specifically targeted the WASP N-terminal domain. One intrabody comprised the single-chain variable fragment and the other comprised the light-chain variable region single domain of an anti-WASP N-terminal monoclonal antibody. Both intrabodies inhibited the specific interaction between WASP and Btk, which impaired the expression of TNF-α, IL-6, and IL-1β in response to TLR3, TLR7, or TLR9 stimulation. Furthermore, the intrabodies inhibited the phosphorylation of both nuclear factor (NF)-κB and WASP in response to TLR3, TLR7, or TLR9 stimulation, in the Tg bone marrow-derived macrophages. These results suggested that WASP plays important roles in TLR3, TLR7, and TLR9 signaling by associating with Btk in macrophages. - Highlights: • The interaction between WASP and Btk is critical for TLR3, TLR7, and TLR9 signaling. • Anti-WASP intrabodies inhibited several TLR pathways that led to cytokine expression. • Phosphorylation of NF-κB via TLR signaling was inhibited by anti-WASP intrabodies. • WASP phosphorylation via several TLR ligands was inhibited by anti-WASP intrabodies.

  17. Anti-WASP intrabodies inhibit inflammatory responses induced by Toll-like receptors 3, 7, and 9, in macrophages

    International Nuclear Information System (INIS)

    Sakuma, Chisato; Sato, Mitsuru; Oshima, Takuma; Takenouchi, Takato; Chiba, Joe; Kitani, Hiroshi

    2015-01-01

    Wiskott-Aldrich syndrome protein (WASP) is an adaptor molecule in immune cells. Recently, we showed that the WASP N-terminal domain interacted with the SH3 domain of Bruton's tyrosine kinase (Btk), and that the complex formed by WASP and Btk was important for TLR2 and TLR4 signaling in macrophages. Several other studies have shown that Btk played important roles in modulating innate immune responses through TLRs in immune cells. Here, we evaluated the significance of the interaction between WASP and Btk in TLR3, TLR7, and TLR9 signaling. We established bone marrow–derived macrophage cell lines from transgenic (Tg) mice that expressed intracellular antibodies (intrabodies) that specifically targeted the WASP N-terminal domain. One intrabody comprised the single-chain variable fragment and the other comprised the light-chain variable region single domain of an anti-WASP N-terminal monoclonal antibody. Both intrabodies inhibited the specific interaction between WASP and Btk, which impaired the expression of TNF-α, IL-6, and IL-1β in response to TLR3, TLR7, or TLR9 stimulation. Furthermore, the intrabodies inhibited the phosphorylation of both nuclear factor (NF)-κB and WASP in response to TLR3, TLR7, or TLR9 stimulation, in the Tg bone marrow-derived macrophages. These results suggested that WASP plays important roles in TLR3, TLR7, and TLR9 signaling by associating with Btk in macrophages. - Highlights: • The interaction between WASP and Btk is critical for TLR3, TLR7, and TLR9 signaling. • Anti-WASP intrabodies inhibited several TLR pathways that led to cytokine expression. • Phosphorylation of NF-κB via TLR signaling was inhibited by anti-WASP intrabodies. • WASP phosphorylation via several TLR ligands was inhibited by anti-WASP intrabodies

  18. Relationship of peripheral blood TLRs and Tespa1 expression levels with cytokines and oxidative stress in patients with chronic urticarial

    Directory of Open Access Journals (Sweden)

    Yun Xu

    2017-05-01

    Full Text Available Objective: To study the relationship of peripheral blood TLRs and Tespa1 expression levels with cytokines and oxidative stress in patients with chronic urticaria. Methods: A total of 68 patients who were diagnosed with chronic urticaria and treated in Songzi People’s Hospital clinic between June 2014 and April 2017 were selected as the CU group of the research, and 80 healthy volunteers who received physical examination were selected as the control group. TLR2, TLR7 and Tespa1 mRNA expression in peripheral blood mononuclear cells as well as the levels of Th1/Th2 cytokines and oxidative stress indexes in serum were detected. Results: TLR2 and TLR7 mRNA expression in peripheral blood mononuclear cells of CU group were significantly higher than those of control group while Tespa1 mRNA expression was significantly lower than that of control group. Serum IFN-γ, IL-2, TNF-α, T-AOC, SOD and GSH-Px levels of CU group were significantly lower than those of control group, negatively correlated with peripheral blood TLR2 and TLR7 mRNA expression, and positively correlated with Tespa1 mRNA expression; serum IL-4, IL-5, IL-10, IL-31 and MDA levels were significantly higher than those of control group, positively correlated with peripheral blood TLR2 and TLR7 mRNA expression, and negatively correlated with Tespa1 mRNA expression. Conclusions: The changes in peripheral blood TLR2, TLR7 and Tespa1 expression in patients with chronic urticaria can cause the changes in Th1/Th2 immune response and the activation of oxidative stress.

  19. Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Positively Modulates Matrix Metalloproteinase-9 Production in Alveolar Macrophages upon Toll-Like Receptor 7 Signaling and Influenza Virus Infection

    Directory of Open Access Journals (Sweden)

    Yu-Hsiang Lee

    2017-09-01

    Full Text Available Influenza A virus (IAV infection causes significant morbidity and mortality worldwide. Matrix metalloproteinase-9 (MMP-9 degrades extracellular matrix and is involved in the pathology of influenza. It has been reported that MMP-9 mediates neutrophil migration in IAV infection. Whether alveolar macrophages, the first immune cells that encounter IAV, produce MMP-9, and the mechanism of its regulation have never been investigated. As Toll-like receptor 7 (TLR7 is one of the receptors in innate immune cells that recognize IAV, we used TLR7 agonists and IAV to stimulate alveolar macrophage MH-S cells, primary macrophages, and bone marrow neutrophils. Results showed that MMP-9 expression in macrophages is inducible by TLR7 agonists and IAV, yet, MMP-9 production by neutrophils is not inducible by either one of them. We hypothesized that MMP-9 production in macrophages is mediated through TLR7-NF-κB pathway and used microarray to analyze TLR7 agonist-induced NF-κB-related genes. Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1, a positive regulator of NF-κB, is amongst the top highly induced genes. By use of MALT1 inhibitor (z-VRPR-fmk and alveolar macrophages from MALT1-deficient mice, we found that MMP-9 production is MALT1-dependent. While MALT1 can act as a paracaspase in lymphocytes through degrading various signaling proteins, we discovered that MALT1 functions to reduce a negative regulator of NF-κB, cylindromatosis (CYLD, in alveolar macrophages. IAV-induced MMP-9, TNF, and IL-6 in lungs of MALT1-deficient mice are significantly lower than in wild-type mice after intratracheal infection. MALT1-deficient mice also have less body weight loss and longer survival after infection. Taken together, we demonstrated a novel role of MALT1 in regulating alveolar macrophage MMP-9 production whose presence exacerbates the severity of influenza.

  20. Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production.

    Science.gov (United States)

    Tsukamoto, Yumiko; Nagai, Yoshinori; Kariyone, Ai; Shibata, Takuma; Kaisho, Tsuneyasu; Akira, Shizuo; Miyake, Kensuke; Takatsu, Kiyoshi

    2009-04-01

    IL-4 and 8-mercaptoguanosine (8-SGuo) stimulation of CD38-activated B cells induces mu to gamma1 class switch recombination (CSR) at the DNA level leading to a high level of IgG1 production. Although some of signaling events initiated by IL-4 in activated B cells have been characterized, the involvement of TLR/MyD88 and Btk pathway in IL-4-dependent mu to gamma1 CSR has not been thoroughly evaluated. In this study, we characterized receptors for 8-SGuo and differential roles of 8-SGuo and IL-4 in the induction and mu to gamma1 CSR and IgG1 production. The role of TLR7 and MyD88 in 8-SGuo-induced AID expression and mu to gamma1 CSR was documented, as 8-SGuo did not act on CD38-stimulated splenic B cells from Tlr7(-/-) and Myd88(-/-) mice. CD38-activated B cells from Btk-deficient mice failed to respond to TLR7 ligands for the AID expression and CSR, indicating that Btk is also indispensable for the system. Stimulation of CD38-activated B cells with 8-SGuo induced significant AID expression and DNA double strand breaks, but IL-4 stimulation by itself did not trigger mu to gamma1 CSR. Intriguingly, the mu to gamma1 CSR in the B cells stimulated with CD38 and 8-SGuo totally depends on IL-4 stimulation. Similar results were obtained in the activated B cells through BCR and loxoribine, a well-known TLR7 ligand, in place of 8-SGuo. In vivo administration of TLR7 ligand and anti-CD38 antibody induced the generation of CD138(+) IgG1(+) cells. These results indicate that TLR7 is a receptor for 8-SGuo and plays an essential role in the AID and Blimp-1 expression; however it is not enough to complete mu to gamma1 CSR in CD38-activated B cells. IL-4 may be required for the induction of DNA repair system together with AID for the completion of CSR.

  1. Subacromial bursitis with rice bodies : a case report

    International Nuclear Information System (INIS)

    Kim, Bong Soo; Joo, Kyung Bin; Park, Dong Woo; Lee, Hak Soo; Oh, Jae Cheon; Lee, Yong Joo; Lee, Won Mi

    1998-01-01

    Multiple rice bodies in joints or bursae are rarely encountered in patients with rheumatoid arthritis. We report the radiologic findings of massive subacromial bursitis with innumerable rice bodies on the right shoulder of a 38-year-old man with rheumatoid arthritis. Subacromial bursography showed markedly distended bursa with multiple nodular filling defects. Precontrast CT scanning revealed well-demarcated hypodense lesion without calcification in subacromio-subdeltoid bursa. Multiple rice bodies showed slightly high signal intensity of T1WI and T2WI, and no enhancement after gadolinium injection. (author). 7 refs., 4 figs

  2. Traumatic olecranon bursitis

    International Nuclear Information System (INIS)

    Saini, M.; Canoso, J.J.

    1982-01-01

    The affected elbow of 28 patients with traumatic olecranon bursitis was radiographically compared with the homologous elbow of 28 matched controls. Olecranon spurs, amorphous calcium deposits, or both, were present in 16 patients and 4 controls (p<0.01). Air was injected in the bursa in 12 additional patients. Nodules in the bursal floor were noted in 10, and the bursa was partially septated in 8. Olecranon spurs, present in 6 patients, corresponded to the insertion of the triceps tendon. With elbow flexion the bursa flattened and lengthened while the olecranon process glided distally beneath the bursal floor. (Auth.)

  3. Subacromial bursitis with rice bodies : a case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Bong Soo; Joo, Kyung Bin; Park, Dong Woo; Lee, Hak Soo; Oh, Jae Cheon; Lee, Yong Joo; Lee, Won Mi [Hanyang Univ., Seoul (Korea, Republic of). Coll. of Medicine

    1998-04-01

    Multiple rice bodies in joints or bursae are rarely encountered in patients with rheumatoid arthritis. We report the radiologic findings of massive subacromial bursitis with innumerable rice bodies on the right shoulder of a 38-year-old man with rheumatoid arthritis. Subacromial bursography showed markedly distended bursa with multiple nodular filling defects. Precontrast CT scanning revealed well-demarcated hypodense lesion without calcification in subacromio-subdeltoid bursa. Multiple rice bodies showed slightly high signal intensity of T1WI and T2WI, and no enhancement after gadolinium injection. (author). 7 refs., 4 figs.

  4. Pengaruh Pola MACD Histogram IHSG Terhadap Pola MACD Histogram Perusahaan Dari Daftar Indeks LQ45 (Periode Februari s.d Juli 2015 Bursa Efek Jakarta [Effect of MACD Histogram IHSG Patterns to Patterns of Companies Listed on the Jakarta Stock Exchange LQ-45 (Period February till July 2015

    Directory of Open Access Journals (Sweden)

    Heri Fatkhurrokhim

    2015-09-01

    Full Text Available The purpose of this study is to determine the effect of MACDIHSG pattern to the MACD Company pattern in the L045 index on the period of February until July 2015 at the Indonesia Stock Exchange. This study also aims to facilitate investors to make investment decisions in the stock market. This study provides benefits to capital market investors, especially for stock investors in the Indonesia Stock Exchange as a mean of enhancing their insights in the development of technical analysis on investing. For the general public as well in order to know that investing in the stock market differs from gambling since there are analyzes that easy and can be applied very simply. In addition, this research aims to enhance the reader's desire to invest in the stock market. The samples were the closing data price of IHSG and shares ofLQ45 in the period of February until July 2015 in the Indonesia Stock Exchange. Based on the hypothesis testing, it can be explained that the MACD Histogram IHSG has a significant effect on 38 issuers listed in LQ45. As for the difference between the MACD Histogram effect against one company with another company that is very small. From the 38 stocks that rank on the top 3 company, the Summarecon Agung Tbk is on the top 1, that amounted to 98.3348%, then Alam Sutera Reality Lestari Tbk amounted to 98.2376%, and Adhi Katya (Persero Tbk amounted to 98.1320%. The third of these shares have MACD Histogram movement that approaching the MACD Histogram IHSG.

  5. Analgesia para a sutura artroscópica do manguito rotador: estudo comparativo entre o bloqueio interescalênico do plexo braquial e o bloqueio da bursa subacromial contínuo Management of pain after the rotator cuff arthroscopic suture: comparative study among the interescalenic blockade and the continuous intrabursal infusion

    Directory of Open Access Journals (Sweden)

    Alexandre Almeida

    2007-10-01

    Full Text Available OBJETIVO: Comparar o nível de dor pós-operatória de pacientes submetidos à sutura artroscópica da lesão do manguito rotador (MR que receberam protocolos diferentes de analgesia pós-operatória. Demonstrar a relação entre dor e o sexo do paciente, a dimensão da lesão suturada e a utilização da capsulotomia interna. Verificar a prevalência dos efeitos colaterais. MÉTODO: Foram analisados três grupos de pacientes operados entre 1º de junho de 2004 e 31 de maio de 2007. O grupo I foi composto pelos pacientes que receberam bloqueio interescalênico com ropivacaína a 0,75%. No grupo II, o mesmo bloqueio foi acrescido de 150µg de clonidina. No grupo III foi administrado um bolus de 30ml de ropivacaína a 0,75% para infiltração dos portais artroscópicos e diretamente no espaço subacromial, seguido de infusão contínua de ropivacaína a 0,2% em bomba de infusão. Os pacientes foram submetidos à medição da escala analógica visual (EAV com 24 horas após o procedimento. As variáveis estudadas foram: EAV, sexo, tamanho da lesão, necessidade de capsulotomia interna e prevalência dos efeitos colaterais. O estudo avaliou 196 pacientes, dos quais foram excluídos 51, totalizando n = 145 pacientes. O total de pacientes no grupo I foi de 65; no grupo II, de 19; e no grupo III, de 61. RESULTADOS: O índice da EAV médio encontrado no grupo I foi de 3,88 ± 1,737 (3; no grupo II, de 3,8 ± 1,6 (3; e no grupo III, de 1,95 ± 1,6 (2. Houve diferença significativa ao comparar os grupos I e III (p OBJECTIVE: To compare the level of postoperative pain in patients submitted to arthroscopic suture of a rotator cuff lesion who had different analgesia protocols. To demonstrate the relationship between pain and the gender of the patient, the dimension of the lesion sutured, and the use of internal capsulotomy. To check the prevalence of side effects. METHODS: Three groups of patients operated on between June 01, 2004 and May 31, 2007 were analyzed. Group I comprised patients who received interescalenic blockade with 0.75% ropivacaine. In group II, the same blockade was added with 150 µg of clonidine. In group III, a 30 ml bolus of 0.75% ropivacaine was administered to infiltrate the arthroscopic portals and directly in the subacromial space, followed by a continuous infusion of 0.2% ropivacaine with an infusion pump. The patients were submitted to the medication of the EAV analogue-visual scale 24 hours after the procedure. The variables studied were EAV, gender, size of the lesion, need of internal capsulotomy, and prevalence of side effects. The study evaluated 196 patients, 51 of whom were excluded, thus giving a total " n" = 145 patients. The total of patients in group I was 65, in group II, 19, and in group III, 61. RESULTS: The mean EAV index found for group I was 3.88 ± 1,737 (3; in group II, it was 3.8 ± 1.6 (3, and in group III, 1.95 ± 1.6 (2. There was a significant difference when comparing group I to group III (p < 0.001 and when comparing group II to group III (p < 0.001 suggesting less pain felt by patients in group III. There was no pain perception difference between genders (p = 0.700 and among the different sizes of rotator cuff lesion (p = 0.546. There was a pain perception difference between patients that were and those that were not submitted to internal capsulotomy (p = 0.038. There was reduced prevalence of nausea and/or vomiting (p = 0.089 and of pruritus (p = 0.092 in group III as compared to groups I and II. CONCLUSIONS: The protocol of postoperative analgesia with continuous infusion of ropivacaine showed that it is better than the protocols using morphine after the end of the interescalenic blockade effects. There was no difference in pain perception between the genders and according to different sizes of sutured lesions. There was a difference in pain perception by the patients who had and those who have not had internal capsulotomy. The rate of side effects was similar among the analgesia protocols.

  6. Toll-like receptor induced pro-interleukin-1β and interleukin-6 in monocytes are lower in healthy infants compared to adults.

    Science.gov (United States)

    Libraty, Daniel H; Zhang, Lei; Woda, Marcia; Acosta, Luz P; Obcena, Anamae; Brion, Job D; Capeding, Rosario Z

    2013-01-01

    Infants have long been known to have higher infectious diseases morbidity and mortality and suboptimal vaccination responses compared to older children and adults. A variety of differences in innate and adaptive immune responses have been described between these two groups. We compared Toll-like receptor (TLR)-induced production of pro-interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α between 2-month-old infants and adults. TLR 7/8-induced production of pro-IL-1β and IL-6 in monocytes was lower in 2-month-old infants compared to adults. There was no difference in TLR 7/8-induced production of TNF-α. Lower TLR-induced production of pro-IL-1β and IL-6 in innate immune cells during early infancy likely contributes to suboptimal vaccine responses and infectious diseases susceptibility.

  7. Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infants.

    Science.gov (United States)

    Wang, Jennifer P; Zhang, Lei; Madera, Rachel F; Woda, Marcia; Libraty, Daniel H

    2012-07-06

    Sex differences in response to microbial infections, especially viral ones, may be associated with Toll-like receptor (TLR)-mediated responses by plasmacytoid dendritic cells (pDCs). In this study, we identified sex differences in human infant pDC interferon-α production following challenge with the TLR7/8 agonist R-848. Male pDC responses were significantly lower than those of females during early infancy. This difference may be attributed to the androgen surge experienced by males during the early infancy period. Pretreatment of human pDCs with dihydrotestosterone produced a significant reduction in interferon-α production following R-848 challenge. Androgen-mediated regulation of pDC TLR7-driven innate immune responses may contribute to the observed sex differences in response to infections during early infancy.

  8. Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infants

    Directory of Open Access Journals (Sweden)

    Wang Jennifer P

    2012-07-01

    Full Text Available Abstract Background Sex differences in response to microbial infections, especially viral ones, may be associated with Toll-like receptor (TLR-mediated responses by plasmacytoid dendritic cells (pDCs. Results In this study, we identified sex differences in human infant pDC interferon-α production following challenge with the TLR7/8 agonist R-848. Male pDC responses were significantly lower than those of females during early infancy. This difference may be attributed to the androgen surge experienced by males during the early infancy period. Pretreatment of human pDCs with dihydrotestosterone produced a significant reduction in interferon-α production following R-848 challenge. Conclusions Androgen-mediated regulation of pDC TLR7-driven innate immune responses may contribute to the observed sex differences in response to infections during early infancy.

  9. Toll-like receptor induced pro-interleukin-1β and interleukin-6 in monocytes are lower in healthy infants compared to adults.

    Directory of Open Access Journals (Sweden)

    Daniel H Libraty

    Full Text Available Infants have long been known to have higher infectious diseases morbidity and mortality and suboptimal vaccination responses compared to older children and adults. A variety of differences in innate and adaptive immune responses have been described between these two groups. We compared Toll-like receptor (TLR-induced production of pro-interleukin (IL-1β, IL-6, and tumor necrosis factor (TNF-α between 2-month-old infants and adults. TLR 7/8-induced production of pro-IL-1β and IL-6 in monocytes was lower in 2-month-old infants compared to adults. There was no difference in TLR 7/8-induced production of TNF-α. Lower TLR-induced production of pro-IL-1β and IL-6 in innate immune cells during early infancy likely contributes to suboptimal vaccine responses and infectious diseases susceptibility.

  10. Functional effects of Toll-like receptor (TLR3, 7, 9, RIG-I and MDA-5 stimulation in nasal epithelial cells.

    Directory of Open Access Journals (Sweden)

    Lotta Tengroth

    Full Text Available The human nasal epithelium is an important physical barrier, and a part of the innate immune defense that protect against pathogens. The epithelial cells recognize microbial components by pattern-recognition receptors (PRRs, and thereby trigger an immune response. Even though TLR3, TLR7, TLR9, RIG-I and MDA-5 are all known to respond to viral stimulation, their potential role in chronic airway inflammation triggered by local cytokine release remains to be established.mRNA and corresponding protein expression of TLR3, TLR7, TLR9, RIG-I and MDA-5 were analyzed in nasal biopsies and various upper airway epithelial cell lines using real-time reverse transcription PCR, immunohistochemistry and flow cytometry. Ligand induced, cytokine release, was evaluated with ELISA.Nasal biopsies were found to express TLR3, TLR7, TLR9, RIG-I and MDA-5, with the most abundant expression in the surface epithelium. These receptors were verified in primary human nasal epithelial cell (HNEC as well as in the airway epithelial cell lines Detroit-562 and FaDu. Poly(I:C (TLR3 and R-837 (TLR7 stimulation increased secretion of IL-6 and GM-CSF from the nasal mucosa and the epithelial cell lines. CpG (TLR9 stimulation caused release of IL-8 in the nasal mucosa and in FaDu. Poly(I:C/LyoVec (RIG-I/MDA-5 stimulation activated the secretion of IFN-β in the nasal mucosa. A corresponding release was also detected from HNEC and Detroit-562.The nasal epithelium has the ability to recognize viral intrusion through TLR and RLR receptors, and the subsequent response might have a role in exacerbation of inflammatory diseases like allergic rhinitis and chronic rhinosinusitis.

  11. Suppression of the toll-like receptor 7-dependent type I interferon production pathway by autophagy resulting from enterovirus 71 and coxsackievirus A16 infections facilitates their replication.

    Science.gov (United States)

    Song, Jie; Hu, Yajie; Li, Jiaqi; Zheng, Huiwen; Wang, Jingjing; Guo, Lei; Shi, Haijng; Liu, Longding

    2018-01-01

    Toll-like receptors (TLRs) act as molecular sentinels, detecting invading viral pathogens and triggering host innate immune responses, including autophagy. However, many viruses have evolved a series of strategies to manipulate autophagy for their own benefit. Enterovirus 71 (EV71) and coxsackievirus A16 (CA16), as the primary agents causing hand, foot and mouth disease (HFMD), can induce autophagy leading to their replication. Therefore, the objective of this study was to investigate whether enhanced viral replication caused by autophagy in EV71 and CA16 infections was associated with a TLR-related signaling pathway. Our results demonstrate that complete autophagy and incomplete autophagy were observed in human bronchial epithelial (16HBE) cells infected with EV71 and CA16. Moreover, suppression of autophagy by the pharmacological modulator 3-MA significantly and clearly decreased the survival rates and viral replication of EV71 and CA16 in 16HBE cells. Inhibition of autophagy also enhanced the expression of molecules related to the TLR7-dependent type I interferon (IFN-I) production pathway, such as TLR7, MyD88, IRF7 and IFN-α/β. Finally, immunofluorescence staining demonstrated that TLR7 endosome marker M6PR levels were clearly reduced in EV71- and CA16-infected cells, while they were markedly elevated in infected cells treated with 3-MA. These findings suggest that increased EV71 and CA16 replication meditated by autophagy in 16HBE cells might promote degradation of the endosome, leading to suppression of the TLR7-mediated IFN-I signaling pathway.

  12. Map Coordinate Referencing and the use of GPS Datasets in Ghana ...

    African Journals Online (AJOL)

    Map Coordinate Referencing and the use of GPS Datasets in Ghana. ... Journal of Science and Technology (Ghana) ... systems used in Ghana (the Ghana war office system and also the Clarke1880 system) using the Bursa-Wolf model.

  13. Download this PDF file

    African Journals Online (AJOL)

    Jane

    2011-08-15

    Aug 15, 2011 ... formation, aedeagus enters into female corpus bursa and endophallus enters ... Eupryene spermatozoa are nucleated and can fertilize the eggs, ... cantly reduced fecundity and fertility of subsequent adults and hatchability of ...

  14. Analysis of Methods for Ellipsoidal Height Estimation – The Case of ...

    African Journals Online (AJOL)

    Michael

    2016-12-02

    Dec 2, 2016 ... parameter similarity transformation model of Bursa-Wolf. The performance of each of ..... indices are capable of quantifying the size of the error produced by the ..... Certificate in Disaster Risk Management and Environ-mental ...

  15. expansion method for solving nonlinear space–time fractional

    Indian Academy of Sciences (India)

    2016-07-06

    Jul 6, 2016 ... Department of Mathematics, Faculty of Arts and Sciences, Uludag University, 16059, Bursa, Turkey. ∗ ... of fractional calculus dates back to three hundred years ago. ... tions by fractional complex transformation [12,13].

  16. The relationship between chondromalacia patella, medial meniscal tear and medial periarticular bursitis in patients with osteoarthritis

    Directory of Open Access Journals (Sweden)

    Resorlu Mustafa

    2017-11-01

    Full Text Available This study investigated the presence of bursitis in the medial compartment of the knee (pes anserine, semimembranosus-tibial collateral ligament, and medial collateral ligament bursa in osteoarthritis, chondromalacia patella and medial meniscal tears.

  17. Giant iliopectineal bursitis presenting as neuropathy and severe edema of the lower limb: case illustration and review of the literature.

    Science.gov (United States)

    Iwata, Takahiro; Nozawa, Satoshi; Ohashi, Minoru; Sakai, Hiroshi; Shimizu, Katsuji

    2013-05-01

    We report a 61-year-old woman with rheumatoid arthritis (RA: Steinblocker stage III, class 3) who developed severe swelling and neuropathy of the right lower limb caused by an iliopectineal bursa associated with destruction of the hip joint. Physical examination revealed an inguinal mass and groin pain. X-ray examination indicated destruction of the hip joint. Contrast-enhanced computed tomography showed the bursa connected with the hip joint and a markedly compressed external iliac vein among the inguinal ligament, pubis, and bursa. The patient underwent partial synovial resection and total hip arthroplasty for recovery of hip function, and this led to successful resolution of the symptoms and bursa. We present the characteristic images from this case and review all previously reported cases of RA iliopsoas bursitis causing leg swelling or neuropathy, and summarize the background. Since this lesion may cause various symptoms, clinical awareness that iliopsoas bursitis may present with unique clinical symptoms may aid correct diagnosis.

  18. Kurtuncu et al., Afr J Tradit Complement Altern Med. (2016) 13(3):66 ...

    African Journals Online (AJOL)

    1Bülent Ecevit University, Zonguldak School of Nursing, Department of Pediatric ... 2Uludag University, Health Science Faculty, Division of Nursing, Bursa/Turkey ... cause a remission of the sickness and initiate a potential cure to prevent the.

  19. SPACE AND MEANING CHANGE IN URBANIZATION AND MODERNIZATION PROCESS: An Urban Park in the First Capital of the Ottoman Empire

    Directory of Open Access Journals (Sweden)

    Gul ATANUR

    2015-03-01

    Full Text Available The foundations of Westernization Movement in Turkey were laid in late Ottoman Empire. Following the fall of the Ottoman Empire and the proclamation of the republic, urban space became highly important and modernist architects from the west planned a large number of Turkish cities. The concept of urban park was introduced and parks became significant components of modern life in this period. Bursa, too, was influenced by this movement; it was planned by western planners and an urban park was built. However, the meaning of urban parks within the ideal of modern life in Turkey and in Bursa has changed over time.  This study is based on urban development periods in Turkey and it presents the change Bursa Kültürpark in Bursa, the early modern city of Turkey, underwent during the process from modernization to globalization.

  20. Bursitis

    Science.gov (United States)

    ... be ordered include: Removing fluid from the bursa Culture of the fluid Ultrasound MRI Treatment Your provider ... JJ. Bursitis, tendinitis, and other periarticular disorders of sports medicine. In: Goldman L, Schafer AI, eds. Goldman- ...

  1. Experiment list: SRX208212 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available id cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of...SRX208212 mm9 Unclassified Unclassified Blood B-Lymphocytes MeSH Description=Lympho

  2. Experiment list: SRX208218 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available id cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of...SRX208218 mm9 Unclassified Unclassified Blood B-Lymphocytes MeSH Description=Lympho

  3. The Immunomodulatory Small Molecule Imiquimod Induces Apoptosis in Devil Facial Tumour Cell Lines.

    Directory of Open Access Journals (Sweden)

    Amanda L Patchett

    Full Text Available The survival of the Tasmanian devil (Sarcophilus harrisii is threatened by devil facial tumour disease (DFTD. This transmissible cancer is usually fatal, and no successful treatments have been developed. In human studies, the small immunomodulatory molecule imiquimod is a successful immunotherapy, activating anti-tumour immunity via stimulation of toll-like receptor-7 (TLR7 signaling pathways. In addition, imiquimod is a potent inducer of apoptosis in human tumour cell lines via TLR7 independent mechanisms. Here we investigate the potential of imiquimod as a DFTD therapy through analysis of treated DFTD cell lines and Tasmanian devil fibroblasts. WST-8 proliferation assays and annexin V apoptosis assays were performed to monitor apoptosis, and changes to the expression of pro- and anti-apoptotic genes were analysed using qRT-PCR. Our results show that DFTD cell lines, but not Tasmanian devil fibroblasts, are sensitive to imiquimod-induced apoptosis in a time and concentration dependent manner. Induction of apoptosis was accompanied by down-regulation of the anti-apoptotic BCL2 and BCLXL genes, and up-regulation of the pro-apoptotic BIM gene. Continuous imiquimod treatment was required for these effects to occur. These results demonstrate that imiquimod can deregulate DFTD cell growth and survival in direct and targeted manner. In vivo, this may increase DFTD vulnerability to imiquimod-induced TLR7-mediated immune responses. Our findings have improved the current knowledge of imiquimod action in tumour cells for application to both DFTD and human cancer therapy.

  4. The histidine transporter SLC15A4 coordinates mTOR-dependent inflammatory responses and pathogenic antibody production.

    Science.gov (United States)

    Kobayashi, Toshihiko; Shimabukuro-Demoto, Shiho; Yoshida-Sugitani, Reiko; Furuyama-Tanaka, Kaori; Karyu, Hitomi; Sugiura, Yuki; Shimizu, Yukiko; Hosaka, Toshiaki; Goto, Motohito; Kato, Norihiro; Okamura, Tadashi; Suematsu, Makoto; Yokoyama, Shigeyuki; Toyama-Sorimachi, Noriko

    2014-09-18

    SLC15A4 is a lysosome-resident, proton-coupled amino-acid transporter that moves histidine and oligopeptides from inside the lysosome to the cytosol of eukaryotic cells. SLC15A4 is required for Toll-like receptor 7 (TLR7)- and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) and is involved in the pathogenesis of certain diseases including lupus-like autoimmunity. How SLC15A4 contributes to diseases is largely unknown. Here we have shown that B cell SLC15A4 was crucial for TLR7-triggered IFN-I and autoantibody productions in a mouse lupus model. SLC15A4 loss disturbed the endolysosomal pH regulation and probably the v-ATPase integrity, and these changes were associated with disruption of the mTOR pathway, leading to failure of the IFN regulatory factor 7 (IRF7)-IFN-I regulatory circuit. Importantly, SLC15A4's transporter activity was necessary for the TLR-triggered cytokine production. Our findings revealed that SLC15A4-mediated optimization of the endolysosomal state is integral to a TLR7-triggered, mTOR-dependent IRF7-IFN-I circuit that leads to autoantibody production. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Increased expression of endosomal members of toll-like receptor family abrogates wound healing in patients with type 2 diabetes mellitus.

    Science.gov (United States)

    Singh, Kanhaiya; Agrawal, Neeraj K; Gupta, Sanjeev K; Mohan, Gyanendra; Chaturvedi, Sunanda; Singh, Kiran

    2016-10-01

    The inflammatory phase of wound healing cascade is an important determinant of the fate of the wound. Acute inflammation is necessary to initiate proper wound healing, while chronic inflammation abrogates wound healing. Different endosomal members of toll-like receptor (TLR) family initiate inflammatory signalling via a range of different inflammatory mediators such as interferons, internal tissue damaged-associated molecular patterns (DAMPs) and hyperactive effector T cells. Sustained signalling of TLR9 and TLR7 contributes to chronic inflammation by activating the plasmacytoid dendritic cells. Diabetic wounds are also characterised by sustained inflammatory phase. The objective of this study was to analyse the differential expression of endosomal TLRs in human diabetic wounds compared with control wounds. We analysed the differential expression of TLR7 and TLR9 both at transcriptional and translational levels in wounds of 84 patients with type 2 diabetes mellitus (T2DM) and 6 control subjects without diabetes using quantitative real-time polymerase chain reaction (RT-PCR), western blot and immunohistochemistry. TLR7 and TLR9 were significantly up-regulated in wounds of the patients with T2DM compared with the controls and were dependent on the infection status of the diabetic wounds, and wounds with microbial infection exhibited lower expression levels of endosomal TLRs. Altered endosomal TLR expression in T2DM subjects might be associated with wound healing impairment. © 2015 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

  6. Candida septic arthritis with rice body formation: A case report and review of literature

    International Nuclear Information System (INIS)

    Jeong, Yu Mi; Cho, Hyun Yee; Lee, Sheen Woo; Hwang, Yun Mi; Kim, Young Kyu

    2013-01-01

    Rice body formation in a joint or bursa is a rare condition, and is usually associated with rheumatoid arthritis or tuberculous arthritis. Here we describe a case of multiple rice body formation in a shoulder joint and in adjacent bursae, which was confirmed to be due to septic arthritis by Candida species. To the best of our knowledge, rice body formation in Candida septic arthritis in an immune-competent patient has not been previously reported.

  7. Candida septic arthritis with rice body formation: A case report and review of literature

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Yu Mi; Cho, Hyun Yee; Lee, Sheen Woo; Hwang, Yun Mi; Kim, Young Kyu [Gachon University, Gil Hospital, Incheon (Korea, Republic of)

    2013-06-15

    Rice body formation in a joint or bursa is a rare condition, and is usually associated with rheumatoid arthritis or tuberculous arthritis. Here we describe a case of multiple rice body formation in a shoulder joint and in adjacent bursae, which was confirmed to be due to septic arthritis by Candida species. To the best of our knowledge, rice body formation in Candida septic arthritis in an immune-competent patient has not been previously reported.

  8. VALORACION DEL TRATAMIENTO CON ACUPUNTURA Y MOXIBUSTION EN PACIENTES CON BURSITIS DE HOMBRO DE LA CLINICA DE ACUPUNTURA DE LA ESCUELA NACIONAL DE MEDICINA Y HOMEOPATIA.

    OpenAIRE

    DE LEON POLANCO, ALEJANDRO PACIANO

    2009-01-01

    LA BURSITIS ES LA INFLAMACION DE LAS BURSAS, QUE SON PEQUENAS BOLSAS LLENAS DE LIQUIDO SEROSO QUE SE ENCUENTRAN ENTRE LOS TENDONES Y EL PLANO OSEO. LA CINTURA ESCAPULAR TIENE 11 BURSAS LAS CUALES SE PUEDEN AFECTAR UNA O MAS EN FORMA SIMULTANEA CONDICIONANDO DOLOR, INFLAMACION Y LIMITACION FUNCIONAL QUE TRAE COMO CONSECUENCIA TRASTORNOS EN LA VIDA COTIDIANA DEL INDIVIDUO. LA BURSITIS SE CLASIFICA EN AGUDAS Y CRONICAS. LAS POSIBLES ETIOLOGIAS DE LA BURSITIS PUEDEN SER TRAUMATISMOS AGUDOS, PROC...

  9. PENGARUH FREE CASH FLOW DAN STRUKTUR KEMPEMILIKAN TERHADAP DIVIDEND PAYOUT RATIO

    OpenAIRE

    Jurica Lucyanda; Lilyana -

    2012-01-01

    Penelitian ini bertujuan menguji bagaimana free cash flow dan struktur kepemilikan berpengaruh terhadap dividend payout ratio pada perusahaan nonkeuangan yang terdaftar pada Bursa Efek Indonesia. Metode analisis yang digunakan adalah regresi berganda. Penelitian ini menggunakan data empiris dari Bursa Efek Indonesia dengan sampel sebanyak 70 perusahaan per tahun untuk tiga periode (2007-2009). Berdasarkan hasil pengujian, ditemukan bahwa variabel yang mempunyai pengaruh yang signifikan terhad...

  10. Testing the Semi-Strong Form efficiency to differentiate stock returns between Islamic and Non-Islamic firms: Empirical evidence using dividend announcement from Malaysia.

    OpenAIRE

    Saya, Muhammad Mujtuba

    2015-01-01

    This dissertation conducts an event study in the specific area of Efficient Market Hypothesis (EMH). It concentrates on the semi-strong form and focuses on exploring the impact of dividend announcements on share prices’ of Malaysian stock market (Bursa Malaysia). Further, it commences a comparison of Islamic (Shariah) compliant stocks and non-Islamic compliant stocks. A sample of 60 companies (30 Shariah and 30 Non-Shraiah compliant) were selected from the main board of Bursa Malaysia. An eve...

  11. Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity.

    Science.gov (United States)

    Cubillos-Ruiz, Juan R; Engle, Xavier; Scarlett, Uciane K; Martinez, Diana; Barber, Amorette; Elgueta, Raul; Wang, Li; Nesbeth, Yolanda; Durant, Yvon; Gewirtz, Andrew T; Sentman, Charles L; Kedl, Ross; Conejo-Garcia, Jose R

    2009-08-01

    The success of clinically relevant immunotherapies requires reversing tumor-induced immunosuppression. Here we demonstrated that linear polyethylenimine-based (PEI-based) nanoparticles encapsulating siRNA were preferentially and avidly engulfed by regulatory DCs expressing CD11c and programmed cell death 1-ligand 1 (PD-L1) at ovarian cancer locations in mice. PEI-siRNA uptake transformed these DCs from immunosuppressive cells to efficient antigen-presenting cells that activated tumor-reactive lymphocytes and exerted direct tumoricidal activity, both in vivo and in situ. PEI triggered robust and selective TLR5 activation in vitro and elicited the production of hallmark TLR5-inducible cytokines in WT mice, but not in Tlr5-/- littermates. Thus, PEI is a TLR5 agonist that, to our knowledge, was not previously recognized. In addition, PEI-complexed nontargeting siRNA oligonucleotides stimulated TLR3 and TLR7. The nonspecific activation of multiple TLRs (specifically, TLR5 and TLR7) reversed the tolerogenic phenotype of human and mouse ovarian tumor-associated DCs. In ovarian carcinoma-bearing mice, this induced T cell-mediated tumor regression and prolonged survival in a manner dependent upon myeloid differentiation primary response gene 88 (MyD88; i.e., independent of TLR3). Furthermore, gene-specific siRNA-PEI nanocomplexes that silenced immunosuppressive molecules on mouse tumor-associated DCs elicited discernibly superior antitumor immunity and enhanced therapeutic effects compared with nontargeting siRNA-PEI nanocomplexes. Our results demonstrate that the intrinsic TLR5 and TLR7 stimulation of siRNA-PEI nanoparticles synergizes with the gene-specific silencing activity of siRNA to transform tumor-infiltrating regulatory DCs into DCs capable of promoting therapeutic antitumor immunity.

  12. Cytokine overproduction and crosslinker hypersensitivity are unlinked in Fanconi anemia macrophages.

    Science.gov (United States)

    Garbati, Michael R; Hays, Laura E; Rathbun, R Keaney; Jillette, Nathaniel; Chin, Kathy; Al-Dhalimy, Muhsen; Agarwal, Anupriya; Newell, Amy E Hanlon; Olson, Susan B; Bagby, Grover C

    2016-03-01

    The Fanconi anemia proteins participate in a canonical pathway that repairs cross-linking agent-induced DNA damage. Cells with inactivated Fanconi anemia genes are universally hypersensitive to such agents. Fanconi anemia-deficient hematopoietic stem cells are also hypersensitive to inflammatory cytokines, and, as importantly, Fanconi anemia macrophages overproduce such cytokines in response to TLR4 and TLR7/8 agonists. We questioned whether TLR-induced DNA damage is the primary cause of aberrantly regulated cytokine production in Fanconi anemia macrophages by quantifying TLR agonist-induced TNF-α production, DNA strand breaks, crosslinker-induced chromosomal breakage, and Fanconi anemia core complex function in Fanconi anemia complementation group C-deficient human and murine macrophages. Although both M1 and M2 polarized Fanconi anemia cells were predictably hypersensitive to mitomycin C, only M1 macrophages overproduced TNF-α in response to TLR-activating signals. DNA damaging agents alone did not induce TNF-α production in the absence of TLR agonists in wild-type or Fanconi anemia macrophages, and mitomycin C did not enhance TLR responses in either normal or Fanconi anemia cells. TLR4 and TLR7/8 activation induced cytokine overproduction in Fanconi anemia macrophages. Also, although TLR4 activation was associated with induced double strand breaks, TLR7/8 activation was not. That DNA strand breaks and chromosome breaks are neither necessary nor sufficient to account for the overproduction of inflammatory cytokines by Fanconi anemia cells suggests that noncanonical anti-inflammatory functions of Fanconi anemia complementation group C contribute to the aberrant macrophage phenotype and suggests that suppression of macrophage/TLR hyperreactivity might prevent cytokine-induced stem cell attrition in Fanconi anemia. © Society for Leukocyte Biology.

  13. Identification of Glial Activation Markers by Comparison of Transcriptome Changes between Astrocytes and Microglia following Innate Immune Stimulation.

    Science.gov (United States)

    Madeddu, Silvia; Woods, Tyson A; Mukherjee, Piyali; Sturdevant, Dan; Butchi, Niranjan B; Peterson, Karin E

    2015-01-01

    The activation of astrocytes and microglia is often associated with diseases of the central nervous system (CNS). Understanding how activation alters the transcriptome of these cells may offer valuable insight regarding how activation of these cells mediate neurological damage. Furthermore, identifying common and unique pathways of gene expression during activation may provide new insight into the distinct roles these cells have in the CNS during infection and inflammation. Since recent studies indicate that TLR7 recognizes not only viral RNA but also microRNAs that are released by damaged neurons and elevated during neurological diseases, we first examined the response of glial cells to TLR7 stimulation using microarray analysis. Microglia were found to generate a much stronger response to TLR7 activation than astrocytes, both in the number of genes induced as well as fold induction. Although the primary pathways induced by both cell types were directly linked to immune responses, microglia also induced pathways associated with cellular proliferation, while astrocytes did not. Targeted analysis of a subset of the upregulated genes identified unique mRNA, including Ifi202b which was only upregulated by microglia and was found to be induced during both retroviral and bunyavirus infections in the CNS. In addition, other genes including Birc3 and Gpr84 as well as two expressed sequences AW112010 and BC023105 were found to be induced in both microglia and astrocytes and were upregulated in the CNS following virus infection. Thus, expression of these genes may a useful measurement of glial activation during insult or injury to the CNS.

  14. Identification of Glial Activation Markers by Comparison of Transcriptome Changes between Astrocytes and Microglia following Innate Immune Stimulation.

    Directory of Open Access Journals (Sweden)

    Silvia Madeddu

    Full Text Available The activation of astrocytes and microglia is often associated with diseases of the central nervous system (CNS. Understanding how activation alters the transcriptome of these cells may offer valuable insight regarding how activation of these cells mediate neurological damage. Furthermore, identifying common and unique pathways of gene expression during activation may provide new insight into the distinct roles these cells have in the CNS during infection and inflammation. Since recent studies indicate that TLR7 recognizes not only viral RNA but also microRNAs that are released by damaged neurons and elevated during neurological diseases, we first examined the response of glial cells to TLR7 stimulation using microarray analysis. Microglia were found to generate a much stronger response to TLR7 activation than astrocytes, both in the number of genes induced as well as fold induction. Although the primary pathways induced by both cell types were directly linked to immune responses, microglia also induced pathways associated with cellular proliferation, while astrocytes did not. Targeted analysis of a subset of the upregulated genes identified unique mRNA, including Ifi202b which was only upregulated by microglia and was found to be induced during both retroviral and bunyavirus infections in the CNS. In addition, other genes including Birc3 and Gpr84 as well as two expressed sequences AW112010 and BC023105 were found to be induced in both microglia and astrocytes and were upregulated in the CNS following virus infection. Thus, expression of these genes may a useful measurement of glial activation during insult or injury to the CNS.

  15. Porcine neonatal blood dendritic cells, but not monocytes, are more responsive to TLRs stimulation than their adult counterparts.

    Directory of Open Access Journals (Sweden)

    Gael Auray

    Full Text Available The neonatal immune system is often considered as immature or impaired compared to the adult immune system. This higher susceptibility to infections is partly due to the skewing of the neonatal immune response towards a Th2 response. Activation and maturation of dendritic cells (DCs play an important role in shaping the immune response, therefore, DCs are a target of choice for the development of efficient and protective vaccine formulations able to redirect the neonatal immune response to a protective Th1 response. As pigs are becoming more important for vaccine development studies due to their similarity to the human immune system, we decided to compare the activation and maturation of a subpopulation of porcine DCs in adult and neonatal pigs following stimulation with different TLR ligands, which are promising candidates for adjuvants in vaccine formulations. Porcine blood derived DCs (BDCs were directly isolated from blood and consisted of a mix of conventional and plasmacytoid DCs. Following CpG ODN (TLR9 ligand and imiquimod (TLR7 ligand stimulation, neonatal BDCs showed higher levels of expression of costimulatory molecules and similar (CpG ODN or higher (imiquimod levels of IL-12 compared to adult BDCs. Another interesting feature was that only neonatal BDCs produced IFN-α after TLR7 or TLR9 ligand stimulation. Stimulation with CpG ODN and imiquimod also induced enhanced expression of several chemokines. Moreover, in a mixed leukocyte reaction assay, neonatal BDCs displayed a greater ability to induce lymphoproliferation. These findings suggest that when stimulated via TLR7 or TLR9 porcine DCs display similar if not better response than adult porcine DCs.

  16. Recent insights into the implications of metabolism in plasmacytoid dendritic cell innate functions: Potential ways to control these functions [version 2; referees: 1 approved, 2 approved with reservations

    Directory of Open Access Journals (Sweden)

    Philippe Saas

    2017-06-01

    Full Text Available There are more and more data concerning the role of cellular metabolism in innate immune cells, such as macrophages or conventional dendritic cells. However, few data are available currently concerning plasmacytoid dendritic cells (PDC, another type of innate immune cells. These cells are the main type I interferon (IFN producing cells, but they also secrete other pro-inflammatory cytokines (e.g., tumor necrosis factor or interleukin [IL]-6 or immunomodulatory factors (e.g., IL-10 or transforming growth factor-β. Through these functions, PDC participate in antimicrobial responses or maintenance of immune tolerance, and have been implicated in the pathophysiology of several autoimmune diseases, as well as in tumor immune escape mechanisms. Recent data support the idea that the glycolytic pathway (or glycolysis, as well as lipid metabolism (including both cholesterol and fatty acid metabolism may impact some innate immune functions of PDC or may be involved in these functions after Toll-like receptor (TLR 7/9 triggering. The kinetics of glycolysis after TLR7/9 triggering may differ between human and murine PDC. In mouse PDC, metabolism changes promoted by TLR7/9 activation may depend on an autocrine/paracrine loop, implicating type I IFN and its receptor IFNAR. This could explain a delayed glycolysis in mouse PDC. Moreover, PDC functions can be modulated by the metabolism of cholesterol and fatty acids. This may occur via the production of lipid ligands that activate nuclear receptors (e.g., liver X receptor [LXR] in PDC or through limiting intracellular cholesterol pool size (by statin or LXR agonist treatment in these cells. Finally, lipid-activated nuclear receptors (i.e., LXR or peroxisome proliferator activated receptor may also directly interact with pro-inflammatory transcription factors, such as NF-κB. Here, we discuss how glycolysis and lipid metabolism may modulate PDC functions and how this may be harnessed in pathological situations

  17. Polymorphisms of Mannose-binding Lectin and Toll-like Receptors 2, 3, 4, 7 and 8 and the Risk of Respiratory Infections and Acute Otitis Media in Children.

    Science.gov (United States)

    Toivonen, Laura; Vuononvirta, Juho; Mertsola, Jussi; Waris, Matti; He, Qiushui; Peltola, Ville

    2017-05-01

    Mannose-binding lectin (MBL) and toll-like receptors (TLRs) are important components of the innate immune system. We assessed the susceptibility of children with genetic variants in these factors to respiratory infections, rhinovirus infections and acute otitis media. In a prospective cohort study, blood samples from 381 Finnish children were analyzed for polymorphisms in MBL2 at codons 52, 54 and 57, TLR2 Arg753Gln, TLR3 Leu412Phe, TLR4 Asp299Gly, TLR7 Gln11Leu and TLR8 Leu651Leu. Children were followed up for respiratory infections until 24 months of age with daily diaries. Polymerase chain reaction and antigen tests were used for detection of respiratory viruses from nasal swabs. Children with MBL variant genotype had a mean of 59 days with symptoms of respiratory infection per year, compared with 49 days in those with wild-type (P = 0.01). TLR8 polymorphisms were associated with an increased risk and TLR7 polymorphisms with a decreased risk of recurrent rhinovirus infections (P = 0.02 for both). TLR2 polymorphisms were associated with recurrent acute otitis media (P = 0.02). MBL polymorphisms were associated with an increased and TLR7 polymorphisms with a decreased risk of rhinovirus-associated acute otitis media (P = 0.03 and P = 0.006, respectively). Genetic polymorphisms in MBL and TLRs promote susceptibility to or protection against respiratory infections. In addition to environmental factors, genetic variations may explain why some children are more prone to respiratory infections.

  18. Human and Mouse Eosinophils Have Antiviral Activity against Parainfluenza Virus.

    Science.gov (United States)

    Drake, Matthew G; Bivins-Smith, Elizabeth R; Proskocil, Becky J; Nie, Zhenying; Scott, Gregory D; Lee, James J; Lee, Nancy A; Fryer, Allison D; Jacoby, David B

    2016-09-01

    Respiratory viruses cause asthma exacerbations. Because eosinophils are the prominent leukocytes in the airways of 60-70% of patients with asthma, we evaluated the effects of eosinophils on a common respiratory virus, parainfluenza 1, in the lung. Eosinophils recruited to the airways of wild-type mice after ovalbumin sensitization and challenge significantly decreased parainfluenza virus RNA in the lungs 4 days after infection compared with nonsensitized animals. This antiviral effect was also seen in IL-5 transgenic mice with an abundance of airway eosinophils (NJ.1726) but was lost in transgenic eosinophil-deficient mice (PHIL) and in IL-5 transgenic mice crossed with eosinophil-deficient mice (NJ.1726-PHIL). Loss of the eosinophil granule protein eosinophil peroxidase, using eosinophil peroxidase-deficient transgenic mice, did not reduce eosinophils' antiviral effect. Eosinophil antiviral mechanisms were also explored in vitro. Isolated human eosinophils significantly reduced parainfluenza virus titers. This effect did not involve degradation of viral RNA by eosinophil granule RNases. However, eosinophils treated with a nitric oxide synthase inhibitor lost their antiviral activity, suggesting eosinophils attenuate viral infectivity through production of nitric oxide. Consequently, eosinophil nitric oxide production was measured with an intracellular fluorescent probe. Eosinophils produced nitric oxide in response to virus and to a synthetic agonist of the virus-sensing innate immune receptor, Toll-like receptor (TLR) 7. IFNγ increased expression of eosinophil TLR7 and potentiated TLR7-induced nitric oxide production. These results suggest that eosinophils promote viral clearance in the lung and contribute to innate immune responses against respiratory virus infections in humans.

  19. Septic bursitis in immunocompromised patients.

    Science.gov (United States)

    Roschmann, R A; Bell, C L

    1987-10-01

    A retrospective analysis of 29 patients with septic bursitis was undertaken to ascertain if immunocompromised patients differed in their clinical presentations, type of organisms cultured, and outcome when compared with their non-immunocompromised cohorts. Thirty episodes of septic bursitis occurred in 29 patients, 43 percent of which occurred in immunocompromised patients. Despite similar clinical presentations, the bursae of immunocompromised patients took three times longer to sterilize and had a much higher bursal white blood cell count when compared with the bursae of non-immunocompromised patients. The bacteriologic spectrum was essentially identical in both groups; there were no cases in which gram-negative organisms were recovered from infected bursae. No cases of septic bursitis were seen in neutropenic patients. The most common factors contributing to an immunocompromised state were alcoholism or steroid therapy. A successful resolution of septic bursitis was seen in all the patients in the immunocompromised groups.

  20. Bicipitoradial Bursitis: A Review of Clinical Presentation and Treatment

    Directory of Open Access Journals (Sweden)

    Tsz-Lung Choi

    2014-06-01

    Full Text Available The bicipitoradial bursa lies at the insertion of the biceps tendon on the radial tuberosity. It is an unusual site for chronic bursitis and most often results from repetitive mechanical trauma or overuse. Other causes include tuberculosis, immunological complications of rheumatological disease and synovial chondromatosis. Accurate diagnosis requires imaging studies and sometimes histological study. It can be treated conservatively with aspiration and steroid injection. Surgical excision of the bursa is indicated in the case of infection cause, failed conservative treatment with recurrence of the enlarged bursa and pain after aspiration, presence of nerve compression with neurological impairment, mechanical limitation to flexion, and extension of the elbow or biceps tendon degeneration and/or functional impairment.

  1. Olecranon Bursitis Caused by Candida parapsilosis in a Patient with Rheumatoid Arthritis

    Directory of Open Access Journals (Sweden)

    Carla F. Gamarra-Hilburn

    2016-01-01

    Full Text Available Septic bursitis is usually caused by bacterial organisms. However, infectious bursitis caused by fungi is very rare. Herein, we present a 68-year-old woman with long-standing rheumatoid arthritis who developed pain, erythema, and swelling of the right olecranon bursa. Aspiration of the olecranon bursa showed a white blood cell count of 3.1×103/μL (41% neutrophils, 30% lymphocytes, and 29% monocytes. Fluid culture was positive for Candida parapsilosis. She was treated with caspofungin 50 mg intravenously daily for 13 days followed by fluconazole 200 mg orally daily for one week. She responded well to this treatment but had recurrent swelling of the bursa. Bursectomy was recommended but she declined this option. This case, together with other reports, suggests that the awareness of uncommon pathogens, their presentation, and predisposing risk factors are important to establish an early diagnosis and prevent long-term complications.

  2. High-resolution real-time sonography and MR imaging in assessment of osteocartilaginous exostoses

    International Nuclear Information System (INIS)

    Prayer, L.M.; Kropej, D.H.; Wimberger, D.M.; Wurnig, C.F.; Kramer, J.; Kainberger, F.M.; Braun, O.H.; Ritschl, P.W.; Imhof, H.

    1991-01-01

    High-resolution real-time ultrasonography (US) and MR imaging, using both spin-echo (SE) and gradient-echo (GE) sequences, were performed prospectively in 14 patients with solitary osteocartilaginous exostoses to assess cartilage cap thickness and bursa formation. Results were compared to surgical and histopathologic findings in all cases. Both US and MR imaging were useful in evaluating exostotic cartilage cap thickness, which is supposed to be the most reliable sign of malignant transformation. Hyaline cartilage matrix had distinctive features in US and MR imaging caused by its specific histologic composition. The formation of bursae over the protruding exostoses, which results in pain and clinically could raise the suspicion of growth and malignant transformation, was demonstrated best using GE sequences. MR imaging was thus superior to US in the detection of bursa formation. (orig.)

  3. High-resolution real-time sonography and MR imaging in assessment of osteocartilaginous exostoses

    Energy Technology Data Exchange (ETDEWEB)

    Prayer, L.M.; Kropej, D.H.; Wimberger, D.M.; Wurnig, C.F.; Kramer, J.; Kainberger, F.M.; Braun, O.H.; Ritschl, P.W.; Imhof, H. (Vienna Univ. (Austria). Depts. of Radiology, Orthopedic Surgery, Pathology, and the MR Inst.)

    1991-09-01

    High-resolution real-time ultrasonography (US) and MR imaging, using both spin-echo (SE) and gradient-echo (GE) sequences, were performed prospectively in 14 patients with solitary osteocartilaginous exostoses to assess cartilage cap thickness and bursa formation. Results were compared to surgical and histopathologic findings in all cases. Both US and MR imaging were useful in evaluating exostotic cartilage cap thickness, which is supposed to be the most reliable sign of malignant transformation. Hyaline cartilage matrix had distinctive features in US and MR imaging caused by its specific histologic composition. The formation of bursae over the protruding exostoses, which results in pain and clinically could raise the suspicion of growth and malignant transformation, was demonstrated best using GE sequences. MR imaging was thus superior to US in the detection of bursa formation. (orig.).

  4. Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Graham F.; Altman, Michael D.; Andresen, Brian; Baker, James; Brubaker, Jason D.; Chen, Hongmin; Chen, Yiping; Childers, Matthew; Donofrio, Anthony; Ferguson, Heidi; Fischer, Christian; Fischmann, Thierry O.; Gibeau, Craig; Hicks, Alexander; Jin, Sue; Kattar, Sam; Kleinschek, Melanie A.; Leccese, Erica; Lesburg, Charles; Li, Chaomin; Lim, Jongwon; Liu, Duan; Maclean, John K.F.; Mansoor, Faruk; Moy, Lilly Y.; Mulrooney, Erin F.; Necheva, Antoaneta S.; Presland, Jeremy; Rakhilina, Larissa; Yang, Ruojing; Torres, Luis; Zhang-Hoover, Jie; Northrup, Alan (Merck); (Oncorus); (Theravance Biopharma); (AstraZeneca); (Blueprint Medicines)

    2017-06-01

    Interleukin-1 receptor associated kinase 4 (IRAK4) has been implicated in IL-1R and TLR based signaling. Therefore selective inhibition of the kinase activity of this protein represents an attractive target for the treatment of inflammatory diseases. Medicinal chemistry optimization of high throughput screening (HTS) hits with the help of structure based drug design led to the identification of orally-bioavailable quinazoline based IRAK4 inhibitors with excellent pharmacokinetic profile and kinase selectivity. These highly selective IRAK4 compounds show activity in vivo via oral dosing in a TLR7 driven model of inflammation.

  5. Regulación de la actividad biológica de las células NK por receptores de tipo toll y por células dendríticas. Implicancias en la inmunidad contra tumores.

    OpenAIRE

    Girart, María Victoria

    2009-01-01

    Las células NK son células linfoides importantes en la defensa del huésped contra patógenos intracelulares y en la inmunovigilancia contra tumores. Ejercen su actividad biológica a través de la elaboración de citoquinas y el desarrollo de actividad citotóxica, funciones reguladas por familias de receptores activadores e inhibidores. Las células NK humanas expresan receptores de tipo Toll (TLRs) tales como TLR3, TLR7, TLR8 y TLR9, entre otros. Sin embargo poco se conoce acerca del impacto de l...

  6. HMGB1 Is Involved in IFN-α Production and TRAIL Expression by HIV-1-Exposed Plasmacytoid Dendritic Cells: Impact of the Crosstalk with NK Cells.

    OpenAIRE

    Héla Saïdi; Marlène Bras; Pauline Formaglio; Marie-Thérèse Melki; Bruno Charbit; Jean-Philippe Herbeuval; Marie-Lise Gougeon

    2016-01-01

    Plasmacytoid dendritic cells (pDCs) are innate sensors of viral infections and important mediators of antiviral innate immunity through their ability to produce large amounts of IFN-?. Moreover, Toll-like receptor 7 (TLR7) and 9 (TLR9) ligands, such as HIV and CpG respectively, turn pDCs into TRAIL-expressing killer pDCs able to lyse HIV-infected CD4+ T cells. NK cells can regulate antiviral immunity by modulating pDC functions, and pDC production of IFN-? as well as cell?cell contact is requ...

  7. Novel In Vitro/Ex Vivo Animal Modeling for Filovirus Aerosol Infection

    Science.gov (United States)

    2013-09-01

    mycoplasma, and yeast . Whereas, TLR 7 and TLR 8 recognize the ssRNA in most viruses along with anti-viral compounds like imiquimod (Greene 2005). TLR9...type II cell: defender of the alveolus revisited, Respir Res 2001; 2(1):33-46 Greene CM, McElvaney Toll-like receptor expression and function in the...2008, Sept 15; 5(7): 778-82 King BA, Kingma PS, Surfactant protein D deficiency increases lung injury during endotoxemia.Am J Respir Cell Mol

  8. Calcific haemorrhagic bursitis anterior to the knee mimicking a soft tissue sarcoma: report of two cases

    Energy Technology Data Exchange (ETDEWEB)

    Stahnke, M.; Davies, A.M. [Department of Radiology, Royal Orthopaedic Hospital, Woodlands, B31 2AP, Northfield, Birmingham (United Kingdom); Mangham, D.C. [Department of Pathology, Royal Orthopaedic Hospital, Woodlands, B31 2AP, Northfield, Birmingham (United Kingdom)

    2004-06-01

    We describe the radiological and pathological findings of two cases of calcific haemorrhagic bursitis, one involving the superficial infrapatellar bursa and the other the prepatellar bursa. It was the presence of dystrophic calcification within the lesion that suggested a mineralizing soft tissue sarcoma such as synovial sarcoma. As the radiographic and MR features of the two conditions can be similar but the appropriate management very different, rare calcifying haemorrhagic bursitis needs to be included in the differential diagnosis of masses adjacent to the knee joint showing calcification. (orig.)

  9. Calcific haemorrhagic bursitis anterior to the knee mimicking a soft tissue sarcoma: report of two cases

    International Nuclear Information System (INIS)

    Stahnke, M.; Davies, A.M.; Mangham, D.C.

    2004-01-01

    We describe the radiological and pathological findings of two cases of calcific haemorrhagic bursitis, one involving the superficial infrapatellar bursa and the other the prepatellar bursa. It was the presence of dystrophic calcification within the lesion that suggested a mineralizing soft tissue sarcoma such as synovial sarcoma. As the radiographic and MR features of the two conditions can be similar but the appropriate management very different, rare calcifying haemorrhagic bursitis needs to be included in the differential diagnosis of masses adjacent to the knee joint showing calcification. (orig.)

  10. Management and outcome of infective prepatellar bursitis.

    Science.gov (United States)

    Wilson-MacDonald, J.

    1987-01-01

    Forty seven cases of prepatellar bursitis are reported. Twenty one patients had sustained a recent injury with a break in the skin which had caused the infection and seventeen patients were employed in jobs which involved kneeling. Oral antibiotics proved to be inadequate treatment in many cases. Splintage and intravenous antibiotics with or without aspiration of the bursa were usually successful in treating the condition, although nine patients required surgical drainage of the bursa. Twelve patients continued to have symptoms months or years after the infection, particularly those with preexisting chronic bursitis, or those who kneeled at work. There was little difference in the results between the different treatment groups. PMID:3447109

  11. New tentacled leech Ceratobdella quadricornuta n. g., n. sp. (Hirudinida: Piscicolidae) parasitic on the starry skate Raja georgiana Norman from the Scotia Sea, Antarctica.

    Science.gov (United States)

    Utevsky, Andrei; Gordeev, Ilya

    2015-07-01

    A new fish leech Ceratobdella quadricornuta n. g., n. sp. (Hirudinida: Piscicolidae), a parasite of the Antarctic skate Raja georgiana Norman (Rajiformes: Rajidae) collected between the Falkland Islands and South Georgia Island in the Scotia Sea, is described and compared with related genera. Ceratobdella quadricornuta is characterised by an uncommon appearance of its anterior sucker bearing four well-developed tentacles and a unique combination of features of the reproductive and digestive systems: crop and intestine equally developed, posterior crop caeca separated; accessory glands, conductive tissue and external copulatory area lacking; common part of ejaculatory ducts (common atrium) voluminous and muscular, male copulatory bursa short, small ovisacs opening into female copulatory bursa (vagina).

  12. PENGARUH GOOD CORPORATE GOVERNANCE, KUALITAS AUDIT, VOLUNTARY DISCLOSURE TERHADAP COST OF DEBT PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BEI TAHUN 2010-2013

    Directory of Open Access Journals (Sweden)

    Ratu Kistiah

    2014-03-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui apakah good corporate governance, kualitas audit dan voluntary disclosure berpengaruh signifikan terhadap cost of debt. Good corporate governance diproksikan dengan proporsi dewan komisaris independen, kepemilikan manajerial, kepemilikan institusional. Penelitian ini menggunakan data sekunder yaitu perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia Hasil penelitian membuktikan bahwa secara parsial proporsi kepemilikan manajerial berpengaruh signifikan terhadap cost of debt. Sementara itu dewan komisaris independen, kepemilikan institusional, kualitas audit dan voluntary disclosure tidak berpengaruh signifikan terhadap cost of debt. Penelitian ini menggunakan data sekunder yaitu perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia tahun 2010-2013.

  13. Bropirimine inhibits osteoclast differentiation through production of interferon-β

    International Nuclear Information System (INIS)

    Suzuki, Hiroaki; Mochizuki, Ayako; Yoshimura, Kentaro; Miyamoto, Yoichi; Kaneko, Kotaro; Inoue, Tomio; Chikazu, Daichi; Takami, Masamichi; Kamijo, Ryutaro

    2015-01-01

    Bropirimine is a synthetic agonist for toll-like receptor 7 (TLR7). In this study, we investigated the effects of bropirimine on differentiation and bone-resorbing activity of osteoclasts in vitro. Bropirimine inhibited osteoclast differentiation of mouse bone marrow-derived macrophages (BMMs) induced by receptor activator of nuclear factor κB ligand (RANKL) in a concentration-dependent manner. Furthermore, it suppressed the mRNA expression of nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATc1), a master transcription factor for osteoclast differentiation, without affecting BMM viability. Bropirimine also inhibited osteoclast differentiation induced in co-cultures of mouse bone marrow cells (BMCs) and mouse osteoblastic UAMS-32 cells in the presence of activated vitamin D_3. Bropirimine partially suppressed the expression of RANKL mRNA in UAMS-32 cells induced by activated vitamin D_3. Finally, the anti-interferon-β (IFN-β) antibody restored RANKL-dependent differentiation of BMMs into osteoclasts suppressed by bropirimine. These results suggest that bropirimine inhibits differentiation of osteoclast precursor cells into osteoclasts via TLR7-mediated production of IFN-β.

  14. Role of toll-like receptors 3, 4 and 7 in cellular uptake and response to titanium dioxide nanoparticles

    Directory of Open Access Journals (Sweden)

    Peng Chen, Koki Kanehira and Akiyoshi Taniguchi

    2013-01-01

    Full Text Available Innate immune response is believed to be among the earliest provisional cellular responses, and mediates the interactions between microbes and cells. Toll-like receptors (TLRs are critical to these interactions. We hypothesize that TLRs also play an important role in interactions between nanoparticles (NPs and cells, although little information has been reported concerning such an interaction. In this study, we investigated the role of TLR3, TLR4 and TLR7 in cellular uptake of titanium dioxide NP (TiO2 NP agglomerates and the resulting inflammatory responses to these NPs. Our data indicate that TLR4 is involved in the uptake of TiO2 NPs and promotes the associated inflammatory responses. The data also suggest that TLR3, which has a subcellular location distinct from that of TLR4, inhibits the denaturation of cellular protein caused by TiO2 NPs. In contrast, the unique cellular localization of TLR7 has middle-ground functional roles in cellular response after TiO2 NP exposure. These findings are important for understanding the molecular interaction mechanisms between NPs and cells.

  15. Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation

    Directory of Open Access Journals (Sweden)

    Chao-Yang Lai

    2017-01-01

    Full Text Available Psoriasis is a chronic inflammatory autoimmune disease that can be initiated by excessive activation of endosomal toll-like receptors (TLRs, particularly TLR7, TLR8, and TLR9. Therefore, inhibitors of endosomal TLR activation are being investigated for their ability to treat this disease. The currently approved biological drugs adalimumab, etanercept, infliximab, ustekinumab, ixekizumab, and secukizumab are antibodies against effector cytokines that participate in the initiation and development of psoriasis. Several immune modulatory oligonucleotides and small molecular weight compounds, including IMO-3100, IMO-8400, and CPG-52364, that block the interaction between endosomal TLRs and their ligands are under clinical investigation for their effectiveness in the treatment of psoriasis. In addition, several chemical compounds, including AS-2444697, PF-05387252, PF-05388169, PF-06650833, ML120B, and PHA-408, can inhibit TLR signaling. Although these compounds have demonstrated anti-inflammatory activity in animal models, their therapeutic potential for the treatment of psoriasis has not yet been tested. Recent studies demonstrated that natural compounds derived from plants, fungi, and bacteria, including mustard seed, Antrodia cinnamomea extract, curcumin, resveratrol, thiostrepton, azithromycin, and andrographolide, inhibited psoriasis-like inflammation induced by the TLR7 agonist imiquimod in animal models. These natural modulators employ different mechanisms to inhibit endosomal TLR activation and are administered via different routes. Therefore, they represent candidate psoriasis drugs and might lead to the development of new treatment options.

  16. Bropirimine inhibits osteoclast differentiation through production of interferon-β

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Hiroaki [Department of Biochemistry, Showa University School of Dentistry, Tokyo 142-8555 (Japan); Mochizuki, Ayako [Department of Oral Physiology, Showa University School of Dentistry, Tokyo 142-8555 (Japan); Yoshimura, Kentaro; Miyamoto, Yoichi [Department of Biochemistry, Showa University School of Dentistry, Tokyo 142-8555 (Japan); Kaneko, Kotaro [Department of Biochemistry, Showa University School of Dentistry, Tokyo 142-8555 (Japan); Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo 160-0023 (Japan); Inoue, Tomio [Department of Oral Physiology, Showa University School of Dentistry, Tokyo 142-8555 (Japan); Chikazu, Daichi [Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo 160-0023 (Japan); Takami, Masamichi [Department of Pharmacology, Showa University School of Dentistry, Tokyo 142-8555 (Japan); Kamijo, Ryutaro, E-mail: kamijor@dent.showa-u.ac.jp [Department of Biochemistry, Showa University School of Dentistry, Tokyo 142-8555 (Japan)

    2015-11-06

    Bropirimine is a synthetic agonist for toll-like receptor 7 (TLR7). In this study, we investigated the effects of bropirimine on differentiation and bone-resorbing activity of osteoclasts in vitro. Bropirimine inhibited osteoclast differentiation of mouse bone marrow-derived macrophages (BMMs) induced by receptor activator of nuclear factor κB ligand (RANKL) in a concentration-dependent manner. Furthermore, it suppressed the mRNA expression of nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATc1), a master transcription factor for osteoclast differentiation, without affecting BMM viability. Bropirimine also inhibited osteoclast differentiation induced in co-cultures of mouse bone marrow cells (BMCs) and mouse osteoblastic UAMS-32 cells in the presence of activated vitamin D{sub 3}. Bropirimine partially suppressed the expression of RANKL mRNA in UAMS-32 cells induced by activated vitamin D{sub 3}. Finally, the anti-interferon-β (IFN-β) antibody restored RANKL-dependent differentiation of BMMs into osteoclasts suppressed by bropirimine. These results suggest that bropirimine inhibits differentiation of osteoclast precursor cells into osteoclasts via TLR7-mediated production of IFN-β.

  17. Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors.

    LENUS (Irish Health Repository)

    Higgs, Rowan

    2010-01-01

    Ro52 is a member of the TRIM family of single-protein E3 ligases and is also a target for autoantibody production in systemic lupus erythematosus and Sjögren\\'s syndrome. We previously demonstrated a novel function of Ro52 in the ubiquitination and proteasomal degradation of IRF3 following TLR3\\/4 stimulation. We now present evidence that Ro52 has a similar role in regulating the stability and activity of IRF7. Endogenous immunoprecipitation of Ro52-bound proteins revealed that IRF7 associates with Ro52, an effect which increases following TLR7 and TLR9 stimulation, suggesting that Ro52 interacts with IRF7 post-pathogen recognition. Furthermore, we show that Ro52 ubiquitinates IRF7 in a dose-dependent manner, resulting in a decrease in total IRF7 expression and a subsequent decrease in IFN-alpha production. IRF7 stability was increased in bone marrow-derived macrophages from Ro52-deficient mice stimulated with imiquimod or CpG-B, consistent with a role for Ro52 in the negative regulation of IRF7 signalling. Taken together, these results suggest that Ro52-mediated ubiquitination promotes the degradation of IRF7 following TLR7 and TLR9 stimulation. As Ro52 is known to be IFN-inducible, this system constitutes a negative-feedback loop that acts to protect the host from the prolonged activation of the immune response.

  18. Low adiposity during early infancy is associated with a low risk for developing dengue hemorrhagic fever: a preliminary model.

    Directory of Open Access Journals (Sweden)

    Daniel H Libraty

    Full Text Available Dengue virus (DENV infections range from asymptomatic or mild illness to a severe and potentially life threatening disease, dengue hemorrhagic fever (DHF. DHF occurs in primary DENV infections during early infancy. A prospective clinical study of DENV infections during infancy was conducted in San Pablo, Philippines. We found that infants who developed DHF with a primary DENV infection had higher WHO weight-for-age z scores before and at the time of infection compared to infants with primary DENV infections who did not develop DHF. In addition, TLR 7/8-stimulated tumor necrosis factor-α (TNF-α production from myeloid-derived cells was higher among well-nourished infants. Leptin augmented TLR 7/8-mediated TNF-α production in monocytes and decreased intracellular cAMP levels. Circulating leptin levels were elevated during early infancy and correlated with WHO weight-for-age z scores. Our data support a plausible hypothesis as to why well-nourished infants are at risk for developing DHF with their first DENV infection.

  19. Low adiposity during early infancy is associated with a low risk for developing dengue hemorrhagic fever: a preliminary model.

    Science.gov (United States)

    Libraty, Daniel H; Zhang, Lei; Woda, Marcia; Giaya, Kris; Kathivu, Chido Loveness; Acosta, Luz P; Tallo, Veronica; Segubre-Mercado, Edelwisa; Bautista, Analisa; Obcena, AnaMae; Brion, Job D; Capeding, Rosario Z

    2014-01-01

    Dengue virus (DENV) infections range from asymptomatic or mild illness to a severe and potentially life threatening disease, dengue hemorrhagic fever (DHF). DHF occurs in primary DENV infections during early infancy. A prospective clinical study of DENV infections during infancy was conducted in San Pablo, Philippines. We found that infants who developed DHF with a primary DENV infection had higher WHO weight-for-age z scores before and at the time of infection compared to infants with primary DENV infections who did not develop DHF. In addition, TLR 7/8-stimulated tumor necrosis factor-α (TNF-α) production from myeloid-derived cells was higher among well-nourished infants. Leptin augmented TLR 7/8-mediated TNF-α production in monocytes and decreased intracellular cAMP levels. Circulating leptin levels were elevated during early infancy and correlated with WHO weight-for-age z scores. Our data support a plausible hypothesis as to why well-nourished infants are at risk for developing DHF with their first DENV infection.

  20. A designated centre for people with disabilities operated by St Michael's House, Dublin 5

    LENUS (Irish Health Repository)

    Higgs, Rowan

    2010-01-01

    Ro52 is a member of the TRIM family of single-protein E3 ligases and is also a target for autoantibody production in systemic lupus erythematosus and Sjögren\\'s syndrome. We previously demonstrated a novel function of Ro52 in the ubiquitination and proteasomal degradation of IRF3 following TLR3\\/4 stimulation. We now present evidence that Ro52 has a similar role in regulating the stability and activity of IRF7. Endogenous immunoprecipitation of Ro52-bound proteins revealed that IRF7 associates with Ro52, an effect which increases following TLR7 and TLR9 stimulation, suggesting that Ro52 interacts with IRF7 post-pathogen recognition. Furthermore, we show that Ro52 ubiquitinates IRF7 in a dose-dependent manner, resulting in a decrease in total IRF7 expression and a subsequent decrease in IFN-alpha production. IRF7 stability was increased in bone marrow-derived macrophages from Ro52-deficient mice stimulated with imiquimod or CpG-B, consistent with a role for Ro52 in the negative regulation of IRF7 signalling. Taken together, these results suggest that Ro52-mediated ubiquitination promotes the degradation of IRF7 following TLR7 and TLR9 stimulation. As Ro52 is known to be IFN-inducible, this system constitutes a negative-feedback loop that acts to protect the host from the prolonged activation of the immune response.

  1. A new and primitive retrobursal planarian from Australian fresh waters (Platyhelminthes, Turbellaria, Tricladida)

    NARCIS (Netherlands)

    Ball, Ian R.

    1977-01-01

    A primitive freshwater planarian, Eviella hynesae gen. et sp. nov. is described from Australia. It is characterized by its lack of eyes and pigment, possession of caudally branched oviducts, and fully fused testes. Although a primary bursa is absent, its function being taken over by the modified

  2. A New Record from Mount Uludağ for Turkey: Solidago gigantea Aiton

    OpenAIRE

    Yılmaz, Özer

    2017-01-01

    Solidago gigantea Aiton (Asteraceae) is reported for the first time (Uludağ, Bursa) for theFlora of Turkey. Solidago gigantea isclosely related to S. canadensis L.,however, it is differs in having glabrous stems, sparse inflorescence andoblanceolate achenes that are black or fawn coloured. A new identification keyfor Solidago species in Turkey isgiven. Also the distributions of these species are mapped.

  3. Kualitas Corporate Social Responsibility Dan Penghindaran Pajak Dengan Kinerja Laba Sebagai Moderator

    OpenAIRE

    Tjondro, Elisa; Widuri, Retnaningtyas; Maria Katopo, Jacqueline

    2016-01-01

    Tujuan penelitian ini adalah meneliti pengaruh kualitas corporate social responsibility (CSR) terhadap penghindaran pajak dengan kinerja laba sebagai variabel moderator. Penelitian ini menggunakan CSR award sebagai indikator kualitas corporate social responsibility (CSR). Data dianalisis menggunakan Moderated Regression Analysis. Sampel penelitian sebanyak 137 Perusahaan yang terdaftar di Bursa Efek Indonesia dengan 615 pengamatan. Hasil penelitian membuktikan kualitas corporate social respon...

  4. Pigmented villonodular synovitis: MR findings

    International Nuclear Information System (INIS)

    Soler, R.; Rivera, E.; Perez Fontan, F.J.; Yebra, T.; Fuente, C. de la

    1994-01-01

    Pigmented villonodular synovitis is an un-common lesion of the synovium that typically involves diffusely the knee. We present the MR findings of two cases involving the knee,one of them diffuse and the other one localized in the supra patellar bursa. (Author)

  5. Steroid injection for painful shoulder: Usefulness of ultrasound-guided approach

    International Nuclear Information System (INIS)

    Lee, Min Hee

    2004-01-01

    To evaluate the efficacy of steroid injection into the subacromial bursa and biceps tendon sheath for painful shoulders and the usefulness of ultrasound-guided approach. Seventeen shoulders of twelve patients with shoulder pain and limited motion were included, and these patient were clinically diagnosed as a painful arc syndrome. Under ultrasound guidance, steroid injection was performed into the subacormial bursa (13 cases) and biceps tendon sheath (4 cases). In 7 cases, 1 mL of steroid was used while the remaining six patients received a mixture of 1 mL of steroid and 1 ml of lidocaine. Both shoulders of two patients received 0.5 mL of steroid. The location of needle and injection duration of fluid were continuously monitored, and complications such as leakage of steroid were recorded. Medical records were reviewed for the presence of pain relief and increasing range of motion following the injection. On ultrasonogram, the needle within the subacromial bursa and biceps tendon sheath was seen as a linear echogenic structure, and injected fluid was identified. There was neither the leakage of steroid injection nor any other complications. In 16 (94%) of 17 shoulders, there was decreased intensity of shoulder pain while increased range of motion was noted in three patients following the injection. Steroid injection into the subacormial bursa and biceps tendon sheath is effective in treating shoulder pain and limited range of motion of the shoulder, and ultrasound is useful guiding method.

  6. Effects of honeybee ( Apis mellifera ) pollination on seed set in ...

    African Journals Online (AJOL)

    This study was carried out to determine the efficiency of pollination with honeybee (Apis mellifera) on sunflower hybrid seed production under different types of pollination during 2005 and 2006 in Mustafakemalpasa-Bursa, Turkey. Three pollination types (1) in cages with honeybees, (2) hand pollination (in cages) and (3) in ...

  7. Relationship between Teachers' Perceptions of Mobbing and Their Problem Solving Skills

    Science.gov (United States)

    Mutlu Gö?men, Nejla; Güle?, Selma

    2018-01-01

    The purpose of this study is to determine the relationship between classroom teachers' perception of mobbing phenomenon and their problem solving skills. The sample of the study is composed of 208 classroom teachers working in the primary schools in the Osmangazi district of Bursa during the 2013-2014 educational year. The data required for the…

  8. Composition and physical properties of arugula, shepherd's purse, and upland cress oils

    Science.gov (United States)

    The fatty acid, tocopherol and phytosterol profiles of arugula [AO; Eruca vesicaria (L.) Cav. subsp. sativa (Mill.) Thell.], upland cress [UCO; Barbarea verna (Mill.) Asch.], and shepherd's purse [SPO; Capsella bursa-pastoris (L.) Medik.] oils are reported, along with their physical properties. The...

  9. Hybridization between Helicoverpa armigera and Helicoverpa assulta (Lepidoptera: Noctuidae): development and morphological characterization of F1 hybrids

    NARCIS (Netherlands)

    Zhao, X.C.; Dong, J.F.; Tang, Q.B.; Yan, Q.B.; Celbic, I.; Loon, van J.J.A.; Wang, C.Z.

    2005-01-01

    Reciprocal hybridizations between Helicoverpa armigera (Hubner) and Helicoverpa assulta (Guenee) were studied. The cross between females of H. armigera and males of H. assulta yielded only fertile males and sterile individuals lacking an aedeagus, valva or ostium bursae. A total of 492 larvae of the

  10. Anatomy Journal of Africa - Vol 4, No 1 (2015)

    African Journals Online (AJOL)

    Gastro-Pancreatic and Gastro-Duodenopancreatic Ligaments: A Case of Two Unusual Inhabitants of the Omental bursa and their Clinical Implications · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. JO Ashaolu, OO Abimbola, VO Ukwenya, 440 - 443 ...

  11. EFFECTS OF IMMUNOSTIMULANTS ON BROILERS SUFFERING FROM INFECTIOU: BURSAL DISEASE

    Directory of Open Access Journals (Sweden)

    F. Mushtaq, S. A. Khan, A. Aslam, K. Saeed1, G. Saleem and H. Mushtaq

    2003-01-01

    Full Text Available This project was aimed to evaluate immunostimulatory effects of three therapeutic substances in broilers suffering from infectious bursal disease (IBD. For this purpose, 150 chicks were divided into five equal groups i.e. A, B, C, D and E having 30 birds each. Group A, B, C and D were challenged with infectious bursal disease virus. There were three immunostimulatory treatments i.e. levamisole (group A, vitamin E (group B, and bursinex (group C. Groups D and E were untreated control. Bursa body weight index, histopathology of bursa of Fabricius, plasma cell counting in Harderian gland and estimation of antibody response against infectious bursal disease virus was recorded. Vitamin E played a major role in improving the condition of birds suffering from infectious bursal disease, as it showed increased bursa body weight index (BBIx, less histopathological lesions in bursa of Fabricius, increased number of plasma cells in Harderian gland and high antibody response in infectious bursal disease infected broilers as compared to levamisole and bursinex. Levamisole played a minor role in improving condition of birds, while bursinex did not seem to be much effective against infectious bursal disease virus in this study.

  12. THE PATHOLOGY OF INFECTIOUS BURSAL DISEASE IN ...

    African Journals Online (AJOL)

    An outbreak of infectious bursal disease (IBD) occurred in a flock of 11-week old crossbreeds of Harco cocks and indigenous Nigerian hens (referred to as exotic and locals respectively in the text). Clinical signs observed include depression, anorexia, ruffled feathers and diarrhoea. Haemorrhages were present in the bursa ...

  13. REKONSTRUKSI LAPORAN KEUANGAN BERBASIS ZAKAT UNTUK PERUSAHAAN DAGANG

    OpenAIRE

    Pratiwi, A.Iswi

    2008-01-01

    2013 Penelitian ini bertujuan untuk merekonstruksi laporan keuangan berbasis zakat pada perusahaan dagang. Metode penelitian yang digunakan adalah deskriptif. Data yang digunakan adalah data sekunder, berupa laporan keuangan PT. Ramayana Lestari Sentosa Tbk untuk periode yang berakhir 31 Desember 2010 dan telah diaudit oleh akuntan publik. Perusahaan ini telah terdaftar di Bursa Efek Indonesia sekaligus terdaftar pada Jakarta ...

  14. A Study on the Evaluation of Science Projects of Primary School Students Based on Scientific Criteria

    Science.gov (United States)

    Gungor, Sema Nur; Ozer, Dilek Zeren; Ozkan, Muhlis

    2013-01-01

    This study re-evaluated 454 science projects that were prepared by primary school students between 2007 and 2011 within the scope of Science Projects Event for Primary School Students. Also, submitted to TUBITAK BIDEB Bursa regional science board by MNE regional work groups in accordance with scientific research methods and techniques, including…

  15. Effect of Low Protein-Methionine-and-Lysine-Supplemented Diets ...

    African Journals Online (AJOL)

    Two experiments were conducted to investigate the effect of supplementing low CP diets with methionine and lysine on broiler performance, carcass measure and their immune response against Infectious Bursa Disease (IBD) virus. In Experiment 1, ten diets were formulated. Diet 1 (control diet) contained 23.0% CP and ...

  16. A new species of nematode (Molineidae) from Rhinella marina (Amphibia: Bufonidae) in Guerrero, México.

    Science.gov (United States)

    Ruiz-Torres, Nallely; García-Prieto, Luis; Osorio-Sarabia, David; Violante-González, Juan

    2013-06-01

    Oswaldocruzia lamotheargumedoi n. sp., inhabiting the intestine of the cane toad, Rhinella marina (L.), in Laguna de Coyuca, Guerrero, México, is described here. The new species differs from 10 congeners infecting bufonid hosts because it has a type I bursa. In contrast, 7 of these species have type II bursa and 3 more a type III bursa. The species most similar to the species described herein is Oswaldocruzia pipiens Walton, 1929 . These 2 species share traits such as body size, bursa type, presence of cervical alae, and dorsal ray morphology. Nevertheless, both species can be distinguished based on the number of synlophe ridges at mid-body (54-56 for O. lamotheargumedoi vs. 45-48 for O. pipiens) and by the presence of a chitinous support in the long, and well developed, cervical alae of O. pipiens. In the new species, these structures are short, poorly developed, and lack chitinous support. Previous records of species of Oswaldocruzia in México include Oswaldocruzia subauricularis (Rudolphi, 1819) Travassos, 1917 in the Neotropical Realm and O. pipiens in the Nearctic.

  17. Burnout Syndrome Levels of Teachers in Special Education Schools in Turkey

    Science.gov (United States)

    Kucuksuleymanoglu, Ruyam

    2011-01-01

    The purpose of this study is to determine whether burnout levels of special education teachers working with hearing, orthopedic and mentally impaired students in Bursa, Turkey differ according to some independent variables such as gender, family status, years of teaching experience, educational background and school type. A descriptive approach…

  18. Ergonomic varicocele ligation: laparoscopic intracorporeal knot-tying

    African Journals Online (AJOL)

    Department of Pediatric Surgery, Sevket Yilmaz Education and Research. Hospital, Bursa, Turkey ... laparoscopic approach to varicocelectomy has been the high associated ... bilateral varicoceles, a 3 mm trocar was placed at the right. McBurney's .... open-high or subinguinal ligation (microsurgical), laparo- scopic methods ...

  19. Achilles Pain.

    Science.gov (United States)

    Connors, G. Patrick

    Five ailments which can cause pain in the achilles tendon area are: (1) muscular strain, involving the stretching or tearing of muscle or tendon fibers; (2) a contusion, inflammation or infection called tenosynovitis; (3) tendonitis, the inflammation of the tendon; (4) calcaneal bursitis, the inflammation of the bursa between the achilles tendon…

  20. Rice body formation in bicipito-radial bursitis: ultrasound, CT, and MRI findings

    International Nuclear Information System (INIS)

    Spence, L.D.; Adams, J.; Eustace, S.; Gibbons, D.; Mason, M.D.

    1998-01-01

    The bicipito-radial bursa, which lies at the biceps tendon insertion on the radial tuberosity, is a rare site of chronic bursitis. We describe the clinical, radiological, and pathological findings in a case complicated by multiple rice body formation. In so doing, we describe MR appearances that allow discrimination of this entity from both synovial chondromatosis and pigmented villonodular synovitis. (orig.)