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Sample records for vibdv-infected bursa tlr7

  1. TLR7 agonist induced repression of hepatocellular carcinoma via the TLR7-IKK-NF-?B-IL6 signaling pathway

    OpenAIRE

    REN, XINGBIN; WANG, FEI; JI, BAOJU; GAO, CHUNHAI

    2016-01-01

    Toll-like receptors (TLRs) are key members of innate immunity, involved in the defense against diseases, and evidence has revealed that TLR4/5 is involved in the carcinogenesis of hepatic cancer. TLR7 belongs to the TLR family, and its roles in immune-associated hepatic diseases have been well characterized; however, the consequences of agonist targeting of TLR7 in hepatic cancer have not previously been reported. The present study aimed to investigate the effects and underlying mechanisms of...

  2. TLR7 influences germinal center selection in murine SLE.

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    Boneparth, Alexis; Huang, Weiqing; Bethunaickan, Ramalingam; Woods, Megan; Sahu, Ranjit; Arora, Shitij; Akerman, Meredith; Lesser, Martin; Davidson, Anne

    2015-01-01

    TLR7 enhances germinal center maturation and migration of B cells to the dark zone where proliferation and somatic hypermutation occur. Our goal was to determine how Tlr7 dose influences selection of the autoreactive B cell repertoire in NZW/BXSB. Yaa mice bearing the site-directed heavy chain transgene 3H9 that encodes for the TLR7 regulated anti-CL response. To create a physiologic setting in which autoreactive B cells compete for survival with non-autoreactive B cells, we generated bone marrow chimeras in which disease onset occurred with similar kinetics and the transferred 3H9+ female non-Yaa, male Yaa or male TLR7(-/Yaa) cells could be easily identified by positivity for GFP. Deletion of 3H9 B cells occurred in the bone marrow and the remaining 3H9 follicular B cells manifested a decrease in surface IgM. Although there were differences in the naïve repertoire between the chimeras it was not possible to distinguish a clear pattern of selection against lupus related autoreactivity in TLR7(-/Yaa) or female chimeras. By contrast, preferential expansion of 3H9+ B cells occurred in the germinal centers of male Yaa chimeras. In addition, although all chimeras preferentially selected 3H9/Vκ5 encoded B cells into the germinal center and plasma cell compartments, 3H9 male Yaa chimeras had a more diverse repertoire and positively selected the 3H9/Vκ5-48/Jκ4 pair that confers high affinity anti-cardiolipin activity. We were unable to demonstrate a consistent effect of Tlr7 dose or Yaa on somatic mutations. Our data show that TLR7 excess influences the selection, expansion and diversification of B cells in the germinal center, independent of other genes in the Yaa locus.

  3. TLR7 influences germinal center selection in murine SLE.

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    Alexis Boneparth

    Full Text Available TLR7 enhances germinal center maturation and migration of B cells to the dark zone where proliferation and somatic hypermutation occur. Our goal was to determine how Tlr7 dose influences selection of the autoreactive B cell repertoire in NZW/BXSB. Yaa mice bearing the site-directed heavy chain transgene 3H9 that encodes for the TLR7 regulated anti-CL response. To create a physiologic setting in which autoreactive B cells compete for survival with non-autoreactive B cells, we generated bone marrow chimeras in which disease onset occurred with similar kinetics and the transferred 3H9+ female non-Yaa, male Yaa or male TLR7(-/Yaa cells could be easily identified by positivity for GFP. Deletion of 3H9 B cells occurred in the bone marrow and the remaining 3H9 follicular B cells manifested a decrease in surface IgM. Although there were differences in the naïve repertoire between the chimeras it was not possible to distinguish a clear pattern of selection against lupus related autoreactivity in TLR7(-/Yaa or female chimeras. By contrast, preferential expansion of 3H9+ B cells occurred in the germinal centers of male Yaa chimeras. In addition, although all chimeras preferentially selected 3H9/Vκ5 encoded B cells into the germinal center and plasma cell compartments, 3H9 male Yaa chimeras had a more diverse repertoire and positively selected the 3H9/Vκ5-48/Jκ4 pair that confers high affinity anti-cardiolipin activity. We were unable to demonstrate a consistent effect of Tlr7 dose or Yaa on somatic mutations. Our data show that TLR7 excess influences the selection, expansion and diversification of B cells in the germinal center, independent of other genes in the Yaa locus.

  4. The Processed Amino-Terminal Fragment of Human TLR7 Acts as a Chaperone To Direct Human TLR7 into Endosomes

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    Shepherd, Dawn; Booth, Sarah; Waithe, Dominic; Reis e Sousa, Caetano

    2015-01-01

    TLR7 mediates innate immune responses to viral RNA in endocytic compartments. Mouse and human (h)TLR7 undergo proteolytic cleavage, resulting in the generation of a C-terminal fragment that accumulates in endosomes and associates with the signaling adaptor MyD88 upon receptor triggering by TLR7 agonists. Although mouse TLR7 is cleaved in endosomes by acidic proteases, hTLR7 processing can occur at neutral pH throughout the secretory pathway through the activity of furin-like proprotein convertases. However, the mechanisms by which cleaved hTLR7 reaches the endosomal compartment remain unclear. In this study, we demonstrate that, after hTLR7 proteolytic processing, the liberated amino (N)-terminal fragment remains bound to the C terminus through disulfide bonds and provides key trafficking information that ensures correct delivery of the complex to endosomal compartments. In the absence of the N-terminal fragment, the C-terminal fragment is redirected to the cell surface, where it is functionally inactive. Our data reveal a novel role for the N terminus of hTLR7 as a molecular chaperone that provides processed hTLR7 with the correct targeting instructions to reach the endosomal compartment, hence ensuring its biological activity and preventing inadvertent cell surface responses to self-RNA. PMID:25917086

  5. TLR7-expressing cells comprise an interfollicular epidermal stem cell population in murine epidermis.

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    Yin, Chaoran; Zhang, Ting; Qiao, Liangjun; Du, Jia; Li, Shuang; Zhao, Hengguang; Wang, Fangfang; Huang, Qiaorong; Meng, Wentong; Zhu, Hongyan; Bu, Hong; Li, Hui; Xu, Hong; Mo, Xianming

    2014-07-25

    Normal interfollicular epidermis (IFE) homeostasis is maintained throughout the entire life by its own stem cells that self-renew and generate progeny that undergo terminal differentiation. However, the fine markers of the stem cells in interfollicular epidermis are not well defined yet. Here we found that TLR7 identified the existence of progenitors and interfollicular epidermal stem cells in murine skin. In vitro, TLR7-expressing cells comprised of two subpopulations that were competent to proliferate and exhibited distinct differentiation potentials. Three-dimensional (3D) organotypic culture and skin reconstitution assays showed that TLR7-expressing cells were able to reconstruct the interfollicular epidermis. Finally, TLR7-expressing cells maintained the intact interfollicular epidermal structures revealed in serial transplantation assays in vivo in mice. Taken together, our results suggest that TLR7-expressing cells comprise an interfollicular epidermal stem cell population.

  6. Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides.

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    Shinchi, Hiroyuki; Crain, Brian; Yao, Shiyin; Chan, Michael; Zhang, Shannon S; Ahmadiiveli, Alast; Suda, Yasuo; Hayashi, Tomoko; Cottam, Howard B; Carson, Dennis A

    2015-08-19

    Toll-like receptors (TLRs) in the innate immune system recognize specific pathogen-associated molecular patterns derived from microbes. Synthetic small molecule TLR7 agonists have been extensively evaluated as topical agents for antiviral and anticancer therapy, and as adjuvants for vaccine. However, safe and reproducible administration of synthetic TLR7 ligands has been difficult to achieve due to undesirable pharmacokinetics and unacceptable side effects. Here, we conjugated a versatile low molecular weight TLR7 ligand to various polysaccharides in order to improve its water solubility, enhance its potency, and maintain low toxicity. The synthetic TLR7 ligand, 2-methoxyethoxy-8-oxo-9-(4-carboxy benzyl)adenine, designated 1V209, was stably conjugated to primary amine functionalized Ficoll or dextran using benzoic acid functional groups. The conjugation ratios using specified equivalents of TLR7 ligand were dose responsive and reproducible. The zeta potential value of the polysaccharides was decreased in inverse proportion to the ratio of conjugated TLR7 ligand. These conjugates were highly water-soluble, stable for at least 6 months at room temperature in aqueous solution, and easy to lyophilize and reconstitute without altering potency. In vitro studies with murine mononuclear leukocytes showed that the TLR7 agonist conjugated to polysaccharides had 10- to 1000-fold higher potencies than the unconjugated TLR7 ligand. In vivo pharmacodynamics studies after injection indicate that the conjugates induced systemic cytokine production. When the conjugates were used as vaccine adjuvants, they enhanced antigen specific humoral and cellular immune responses to a much greater extent than did unconjugated TLR7 ligands. These results indicated that small molecule TLR7 ligands conjugated to polysaccharides have improved immunostimulatory potency and pharmacodynamics. Polysaccharides can be conjugated to a variety of molecules such as antigens, peptides, and TLR ligands

  7. Asparagine endopeptidase controls anti-influenza virus immune responses through TLR7 activation.

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    Sophia Maschalidi

    Full Text Available Intracellular Toll-like receptors (TLRs expressed by dendritic cells recognize nucleic acids derived from pathogens and play an important role in the immune responses against the influenza virus (IAV, a single-stranded RNA sensed by different receptors including TLR7. However, the importance of TLR7 processing in the development of anti-viral immune responses is not known. Here we report that asparagine endopeptidase (AEP deficient mice are unable to generate a strong anti-IAV response, as demonstrated by reduced inflammation, cross presentation of cell-associated antigens and priming of CD8(+ T cells following TLR7-dependent pulmonary infection induced by IAV. Moreover, AEP deficient lung epithelial- or myeloid-cells exhibit impaired TLR7 signaling due to defective processing of this receptor. Indeed, TLR7 requires a proteolytic cleavage by AEP to generate a C-terminal fragment competent for signaling. Thus, AEP activity is critical for TLR7 processing, opening new possibilities for the treatment of influenza and TLR7-dependent inflammatory diseases.

  8. The TIR-domain containing adaptor TRAM is required for TLR7 mediated RANTES production.

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    Enda Shevlin

    Full Text Available Toll-like receptor 7 (TLR7 plays a vital role in the immune response to ssRNA viruses such as human rhinovirus (HRV and Influenza, against which there are currently no treatments or vaccines with long term efficacy available. Clearly, a more comprehensive understanding of the TLR7 signaling axis will contribute to its molecular targeting. TRIF related adaptor molecule (TRAM plays a vital role in TLR4 signaling by recruiting TRIF to TLR4, followed by endosomal trafficking of the complex and initiation of IRF3 dependent type I interferon production as well as NF-κB dependent pro-inflammatory cytokine production. Towards understanding the molecular mechanisms that regulate TLR7 functionality, we found that TRAM(-/- murine macrophages exhibited a transcriptional and translational impairment in TLR7 mediated RANTES, but not TNFα, production. Suppression of TRAM expression in human macrophages also resulted in an impairment in TLR7 mediated CCL5 and IFN-β, but not TNFα, gene induction. Furthermore, suppression of endogenous human TRAM expression in human macrophages significantly impaired RV16 induced CCL5 and IFNβ, but not TNFα gene induction. Additionally, TRAM-G2A dose-dependently inhibited TLR7 mediated activation of CCL5, IFNβ and IFNα reporter genes. TLR7-mediated phosphorylation and nuclear translocation of IRF3 was impaired in TRAM(-/- cells. Finally, co-immunoprecipitation studies indicated that TRAM physically interacts with MyD88 upon TLR7 stimulation, but not under basal conditions. Our results clearly demonstrate that TRAM plays a, hitherto unappreciated, role in TLR7 signaling through a novel signaling axis containing, but not limited to, MyD88, TRAM and IRF3 towards the activation of anti-viral immunity.

  9. Massive prepatellar bursa.

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    Thompson, Terry L; Simpson, Bonnie M; Burgess, Derrick; Wilson, Robert H

    2006-01-01

    An adult male with cerebral palsy was admitted to our institution with a massive prepatellar bursa. The condition resulted from the patient's use of crawling as a means of household ambulation. The bursa had become infected secondarily, prompting him to seek medical attention. The bursa was excised in its entirety, allowing for relief of his symptoms. The patient expired three years later from unrelated causes.

  10. TLR7 deficiency contributes to attenuated diabetic retinopathy via inhibition of inflammatory response.

    Science.gov (United States)

    Liao, Yun-Ru; Li, Zi-Jing; Zeng, Peng; Lan, Yu-Qing

    2017-11-18

    Diabetic retinopathy (DR) is a major microvascular complication of diabetes, resulting in neuronal dysfunction, retinal vascular leakage, and apoptosis within the retina. Innate immunity plays an important role in the pathogenesis of type 2 diabetes (T2D) and related complications. The toll-like receptors (TLRs), central to innate immunity, are essential participants in the progression and pathogenesis of the disease and its complications. In the study, streptozotocin (STZ) was combined with whole-body hypoxia for quicker induction of early-stage diabetic retinopathy (DR) in the wild type (WT) and TLR7-knockout (KO) C57BL/6 mice. The effects of TLR7 were also investigated in fructose-treated retinal pigment epithelial (RPE) cells. In the retinas of WT/DR mice, abnormal a-wave and b-wave activity, hyperfluorescence, and reduced retinal thickness were observed. DR development was associated with enhanced TLR7 expression, whose deletion dramatically reduced VEGF expression levels. And the secretion of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, IL-18 and IL-12, was highly reduced by TLR7-deficiency in DR mice. Consistently, WT/DR mice exhibited higher phosphorylation of IκB kinase α (IKKα), inhibitor of NF-κB α (IκBα) and nuclear factor κB (NF-κB), which were found to be down-regulated in KO/DR mice. Similarly, DR-induced mitogen-activated protein kinases (MAPKs) activation was blocked by TLR7-knockout. In vitro, fructose incubation-triggered inflammation was reversed by TLR7 knockdown, accompanied with inactivated NF-κB and MAPKs pathways. And reduced reactive oxygen species (ROS) generation was observed in TLR7-knockdown cells with fructose treatment. Together, inhibiting TLR7 suppressed diabetic retinopathy by reducing inflammation and suggested a potential application in clinics. Copyright © 2017. Published by Elsevier Inc.

  11. Tumor promotion by intratumoral plasmacytoid dendritic cells is reversed by TLR7 ligand treatment.

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    Le Mercier, Isabelle; Poujol, Dominique; Sanlaville, Amélien; Sisirak, Vanja; Gobert, Michael; Durand, Isabelle; Dubois, Bertrand; Treilleux, Isabelle; Marvel, Jacqueline; Vlach, Jaromir; Blay, Jean-Yves; Bendriss-Vermare, Nathalie; Caux, Christophe; Puisieux, Isabelle; Goutagny, Nadège

    2013-08-01

    Plasmacytoid dendritic cells (pDC) are key regulators of antiviral immunity. In previous studies, we reported that pDC-infiltrating human primary breast tumors represent an independent prognostic factor associated with poor outcome. To understand this negative impact of tumor-associated pDC (TApDC), we developed an orthotopic murine mammary tumor model that closely mimics the human pathology, including pDC and regulatory T cell (Treg) infiltration. We showed that TApDC are mostly immature and maintain their ability to internalize antigens in vivo and to activate CD4(+) T cells. Most importantly, TApDC were specifically altered for cytokine production in response to Toll-like receptor (TLR)-9 ligands in vitro while preserving unaltered response to TLR7 ligands (TLR7L). In vivo pDC depletion delayed tumor growth, showing that TApDC provide an immune-subversive environment, most likely through Treg activation, thus favoring tumor progression. However, in vivo intratumoral administration of TLR7L led to TApDC activation and displayed a potent curative effect. Depletion of pDC and type I IFN neutralization prevented TLR7L antitumoral effect. Our results establish a direct contribution of TApDC to primary breast tumor progression and rationalize the application of TLR7 ligands to restore TApDC activation in breast cancer. Cancer Res; 73(15); 4629-40. ©2013 AACR.

  12. Structure Based Modeling of Small Molecules Binding to the TLR7 by Atomistic Level Simulations

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    Francesco Gentile

    2015-05-01

    Full Text Available Toll-Like Receptors (TLR are a large family of proteins involved in the immune system response. Both the activation and the inhibition of these receptors can have positive effects on several diseases, including viral pathologies and cancer, therefore prompting the development of new compounds. In order to provide new indications for the design of Toll-Like Receptor 7 (TLR7-targeting drugs, the mechanism of interaction between the TLR7 and two important classes of agonists (imidazoquinoline and adenine derivatives was investigated through docking and Molecular Dynamics simulations. To perform the computational analysis, a new model for the dimeric form of the receptors was necessary and therefore created. Qualitative and quantitative differences between agonists and inactive compounds were determined. The in silico results were compared with previous experimental observations and employed to define the ligand binding mechanism of TLR7.

  13. Steroid injections - tendon, bursa, joint

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    ... gov/ency/article/007678.htm Steroid injections - tendon, bursa, joint To use the sharing features on this ... can be injected into a joint, tendon, or bursa. Description Your health care provider inserts a small ...

  14. Imaging of the Bursae

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    Hirji, Zameer; Hunjun, Jaspal S; Choudur, Hema N

    2011-01-01

    When assessing joints with various imaging modalities, it is important to focus on the extraarticular soft tissues that may clinically mimic joint pathology. One such extraarticular structure is the bursa. Bursitis can clinically be misdiagnosed as joint-, tendon- or muscle-related pain. Pathological processes are often a result of inflammation that is secondary to excessive local friction, infection, arthritides or direct trauma. It is therefore important to understand the anatomy and pathology of the common bursae in the appendicular skeleton. The purpose of this pictorial essay is to characterize the clinically relevant bursae in the appendicular skeleton using diagrams and corresponding multimodality images, focusing on normal anatomy and common pathological processes that affect them. The aim is to familiarize radiologists with the radiological features of bursitis. PMID:21966619

  15. Respiratory virus-induced TLR7 activation controls IL-17-associated increased mucus via IL-23 regulation

    NARCIS (Netherlands)

    Lukacs, Nicholas W; Smit, Joost J; Mukherjee, Sumanta; Morris, Susan B; Nunez, Gabriel; Lindell, Dennis M

    2010-01-01

    The response to respiratory syncytial virus (RSV), negative strand ssRNA virus, depends upon the ability to recognize specific pathogen-associated targets. In the current study, the role of TLR7 that recognizes ssRNA was examined. Using TLR7(-/-) mice, we found that the response to RSV infection in

  16. 2'-O-methyl-modified RNAs act as TLR7 antagonists.

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    Robbins, Marjorie; Judge, Adam; Liang, Lisa; McClintock, Kevin; Yaworski, Ed; MacLachlan, Ian

    2007-09-01

    RNA molecules such as single-stranded RNA (ssRNA) and small interfering RNA (siRNA) duplexes induce Toll-like receptor (TLR)-mediated immune stimulation after intracellular delivery. We have previously shown that selective incorporation of 2'-O-methyl (2'OMe) residues into siRNA abrogates cytokine production without reduction of gene silencing activity. Here we show that 2'OMe-modified RNA acts as a potent inhibitor of RNA-mediated cytokine induction in both human and murine systems. This activity does not require the direct incorporation of 2'OMe nucleotides into the immunostimulatory RNA or that the 2'OMe nucleotide-containing RNA be annealed as a complementary strand to form a duplex. Our results indicate that 2'OMe RNA acts as a potent antagonist of immunostimulatory RNA. We further show that 2'OMe RNA is able significantly to reduce both interferon-alpha (IFN-alpha) and interleukin-6 (IL-6) induction by the small-molecule TLR7 agonist loxoribine in human peripheral blood mononuclear cells (human PBMCs), in murine Flt3L dendritic cells (Flt3L DCs), and in vivo in mice. These results indicate that 2'OMe-modified RNA may have utility as an inhibitor of TLR7 with potential applications in the treatment of inflammatory and autoimmune diseases that involve TLR7-mediated immune stimulation.

  17. Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system.

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    Tomoko Hayashi

    Full Text Available The Toll-like receptors (TLR have been advocated as attractive therapeutic targets because TLR signaling plays dual roles in initiating adaptive immune responses and perpetuating inflammation. Paradoxically, repeated stimulation of bone marrow mononuclear cells with a synthetic TLR7 ligand 9-benzyl-8-hydroxy-2-(2-methoxyethoxy adenine (called 1V136 leads to subsequent TLR hyporesponsiveness. Further studies on the mechanism of action of this pharmacologic agent demonstrated that the TLR7 ligand treatment depressed dendritic cell activation, but did not directly affect T cell function. To verify this mechanism, we utilized experimental allergic encephalitis (EAE as an in vivo T cell dependent autoimmune model. Drug treated SJL/J mice immunized with proteolipid protein (PLP(139-151 peptide had attenuated disease severity, reduced accumulation of mononuclear cells in the central nervous system (CNS, and limited demyelination, without any apparent systemic toxicity. Splenic T cells from treated mice produced less cytokines upon antigenic rechallenge. In the spinal cords of 1V136-treated EAE mice, the expression of chemoattractants was also reduced, suggesting innate immune cell hyposensitization in the CNS. Indeed, systemic 1V136 did penetrate the CNS. These experiments indicated that repeated doses of a TLR7 ligand may desensitize dendritic cells in lymphoid organs, leading to diminished T cell responses. This treatment strategy might be a new modality to treat T cell mediated autoimmune diseases.

  18. Differential TLR7-mediated expression of proinflammatory and antiviral cytokines in response to laboratory and clinical enterovirus strains.

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    Chehadeh, Wassim; Alkhabbaz, Marwa

    2013-06-01

    Enteroviruses (EVs) are single stranded RNA viruses associated with many serious diseases. The exact mechanism by which an EV is able to evade innate immunity and cause tissue damage still remain unknown. Toll-like receptor 7 (TLR7) mediates the activation of type I interferon genes and the development of inflammatory cytokine response. The main aim of the study was to explore the antiviral activity and the pattern of cytokine expression in human embryonic kidney cells (HEK-293 cells) expressing TLR7 protein following challenging with laboratory and clinical EV strains. The TLR7 open reading frame was cloned into the pcDNA3.1/nV5-DEST™ expression vector, followed by transfection into HEK-293 cells. TLR7- and mock-transfected cells were infected with laboratory and clinical strains of CVB1 and CVB5. The levels of cytokines (IL-6, IL-8, TNF-α, IFN-α and IFN-β) were measured by ELISA. The EV RNA concentrations were measured by real-time RT-PCR, and normalized against GAPDH RNA concentrations. The clinical EV strains were more effective activators of cytokines production in TLR7-transfected cells than the laboratory EV strains. The inhibition of EV replication in TLR7-transfected cells was correlated to the production of type I IFNs. The cytopathic effects observed in TLR7-transfected cells were correlated to the levels of IL-6 and TNF-α. The results suggest a clear segregation between laboratory and clinical EV strains on the basis of their cytokine induction ability, and a possible role of TLR7-induced proinflammatory cytokines in the pathogenesis of EV infection. Copyright © 2013 Elsevier B.V. All rights reserved.

  19. Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7.

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    Coleman, Leon G; Zou, Jian; Crews, Fulton T

    2017-01-25

    Toll-like receptor (TLR) signaling is emerging as an important component of neurodegeneration. TLR7 senses viral RNA and certain endogenous miRNAs to initiate innate immune responses leading to neurodegeneration. Alcoholism is associated with hippocampal degeneration, with preclinical studies linking ethanol-induced neurodegeneration with central innate immune induction and TLR activation. The endogenous miRNA let-7b binds TLR7 to cause neurodegeneration. TLR7 and other immune markers were assessed in postmortem human hippocampal tissue that was obtained from the New South Wales Tissue Bank. Rat hippocampal-entorhinal cortex (HEC) slice culture was used to assess specific effects of ethanol on TLR7, let-7b, and microvesicles. We report here that hippocampal tissue from postmortem human alcoholic brains shows increased expression of TLR7 and increased microglial activation. Using HEC slice culture, we found that ethanol induces TLR7 and let-7b expression. Ethanol caused TLR7-associated neuroimmune gene induction and initiated the release let-7b in microvesicles (MVs), enhancing TLR7-mediated neurotoxicity. Further, ethanol increased let-7b binding to the danger signaling molecule high mobility group box-1 (HMGB1) in MVs, while reducing let-7 binding to classical chaperone protein argonaute (Ago2). Flow cytometric analysis of MVs from HEC media and analysis of MVs from brain cell culture lines found that microglia were the primary source of let-7b and HMGB1-containing MVs. Our results identify that ethanol induces neuroimmune pathology involving the release of let-7b/HMGB1 complexes in microglia-derived microvesicles. This contributes to hippocampal neurodegeneration and may play a role in the pathology of alcoholism.

  20. Association of TLR7 variants with AIDS-like disease and AIDS vaccine efficacy in rhesus macaques.

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    Roman A Siddiqui

    Full Text Available In HIV infection, TLR7-triggered IFN-α production exerts a direct antiviral effect through the inhibition of viral replication, but may also be involved in immune pathogenesis leading to AIDS. TLR7 could also be an important mediator of vaccine efficacy. In this study, we analyzed polymorphisms in the X-linked TLR7 gene in the rhesus macaque model of AIDS. Upon resequencing of the TLR7 gene in 36 rhesus macaques of Indian origin, 12 polymorphic sites were detected. Next, we identified three tightly linked single nucleotide polymorphisms (SNP as being associated with survival time. Genotyping of 119 untreated, simian immunodeficiency virus (SIV-infected male rhesus macaques, including an 'MHC adjusted' subset, revealed that the three TLR7 SNPs are also significantly associated with set-point viral load. Surprisingly, this effect was not observed in 72 immunized SIV-infected male monkeys. We hypothesize (i that SNP c.13G>A in the leader peptide is causative for the observed genotype-phenotype association and that (ii the underlying mechanism is related to RNA secondary structure formation. Therefore, we investigated a fourth SNP (c.-17C>T, located 17 bp upstream of the ATG translation initiation codon, that is also potentially capable of influencing RNA structure. In c.13A carriers, neither set-point viral load nor survival time were related to the c.-17C>T genotype. In c.13G carriers, by contrast, the c.-17C allele was significantly associated with prolonged survival. Again, no such association was detected among immunized SIV-infected macaques. Our results highlight the dual role of TLR7 in immunodeficiency virus infection and vaccination and imply that it may be important to control human AIDS vaccine trials, not only for MHC genotype, but also for TLR7 genotype.

  1. Plant virus particles carrying tumour antigen activate TLR7 and Induce high levels of protective antibody.

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    Jantipa Jobsri

    Full Text Available Induction of potent antibody is the goal of many vaccines targeted against infections or cancer. Modern vaccine designs that use virus-like particles (VLP have shown efficacy for prophylactic vaccination against virus-associated cancer in the clinic. Here we used plant viral particles (PVP, which are structurally analogous to VLP, coupled to a weak idiotypic (Id tumour antigen, as a conjugate vaccine to induce antibody against a murine B-cell malignancy. The Id-PVP vaccine incorporates a natural adjuvant, the viral ssRNA, which acts via TLR7. It induced potent protective anti-Id antibody responses in an in vivo mouse model, superior to the "gold standard" Id vaccine, with prevalence of the IgG2a isotype. Combination with alum further increased antibody levels and maintained the IgG2a bias. Engagement of TLR7 in vivo was followed by secretion of IFN-α by plasmacytoid dendritic cells and by activation of splenic CD11chi conventional dendritic cells. The latter was apparent from up-regulation of co-stimulatory molecules and from secretion of a wide range of inflammatory cytokines and chemokines including the Th1-governing cytokine IL-12, in keeping with the IgG2a antibody isotype distribution. PVP conjugates are a novel cancer vaccine design, offering an attractive molecular form, similar to VLP, and providing T-cell help. In contrast to VLP, they also incorporate a safe "in-built" ssRNA adjuvant.

  2. A modified dinucleotide motif specifies tRNA recognition by TLR7.

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    Kaiser, Steffen; Rimbach, Katharina; Eigenbrod, Tatjana; Dalpke, Alexander H; Helm, Mark

    2014-09-01

    RNA can function as a pathogen-associated molecular pattern (PAMP) whose recognition by the innate immune system alerts the body to an impending microbial infection. The recognition of tRNA as either self or nonself RNA by TLR7 depends on its modification patterns. In particular, it is known that the presence of a ribose methylated guanosine at position 18, which is overrepresented in self-RNA, antagonizes an immune response. Here, we report that recognition extends to the next downstream nucleotide and the effectively recognized molecular detail is actually a methylated dinucleotide. The most efficient nucleobases combination of this motif includes two purines, while pyrimidines diminish the effect of ribose methylation. The constraints of this motif stay intact when transposed to other parts of the tRNA. The results argue against a fixed orientation of the tRNA during interaction with TLR7 and, rather, suggest a processive type of inspection. © 2014 Kaiser et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  3. Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders

    DEFF Research Database (Denmark)

    Møller-Larsen, Steffen; Nyegaard, Mette; Haagerup, Annette

    2008-01-01

    BACKGROUND: Toll-like receptors (TLRs) are structurally and functionally related and play important roles in the innate and adaptive immune system. By genome scanning, evidence of linkage between chromosome Xp22 and asthma and related atopic disorders has previously been obtained. Xp22 harbours...... the TLR7 and TLR8 genes. METHODS: The involvement of TLR7 and TLR8 in the aetiology of asthma and related disorders was investigated by a family based association analysis of two independently ascertained family samples comprising 540 and 424 individuals from 135 and 100 families, respectively. Ten......). CONCLUSION: The results provide strong evidence that TLR7 and 8 may confer susceptibility to asthma and related atopic disorders and highlight these receptors as interesting targets for individualised, causally directed treatment....

  4. Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders

    DEFF Research Database (Denmark)

    Møller-Larsen, Steffen; Nyegaard, Mette; Haagerup, Annette

    2008-01-01

    BACKGROUND: Toll-like receptors (TLRs) are structurally and functionally related and play important roles in the innate and adaptive immune system. By genome scanning, we have previously obtained evidence of linkage between chromosome Xp22 and asthma and related atopic disorders. Xp22 harbours...... the TLR7 and TLR8 genes. METHODS: We investigated the involvement of TLR7 and TLR8 in the aetiology of asthma and related disorders by a family based association analysis of two independently ascertained family samples comprising 540 and 424 individuals from 135 and 100 families, respectively. Ten......). CONCLUSION: The results presented, provide strong evidence that TLR7 and 8 may confer susceptibility to asthma and related atopic disorders and highlight these receptors as interesting targets for individualized, causally directed treatment....

  5. BANK1 Regulates IgG Production in a Lupus Model by Controlling TLR7-Dependent STAT1 Activation.

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    Ying-Yu Wu

    Full Text Available The purpose of our study was to investigate the effects of the adaptor Bank1 in TLR7 signaling using the B6.Sle1.yaa mouse, a lupus model that develops disease through exacerbated TLR7 expression. Crosses of B6.Sle1.yaa with Bank1-/- mice maintained several B and myeloid cell phenotypes close to normal wild-type levels. Most striking was the reduction in total serum IgG antibodies, but not of IgM, and reduced serum levels of autoantibodies, IL-6, and BAFF. Bank1 deficiency did modify numbers of MZ B cells and total B cell numbers, as well as expression of CXCR4 by follicular helper T cells. Other T cell changes were not observed. Bank1 deficiency did not modify numbers of germinal center B cells or plasma cells or clinical disease outcomes. Purified B cells from Bank1 deficient mice had strongly reduced Ifnb, Ifna4, Irf7, Aicda and Stat1 gene expression following TLR7 agonist stimulation. Interestingly, phosphorylation of Tyr701, but not of Ser727 of STAT1, was impaired in splenic B cells from B6.Sle1.yaa.Bank1-/- mice, as was the nuclear translocation of IRF7 in response to TLR7 agonist stimulation. Further, Bank1 deficiency in B6.Sle1.yaa mice reduced the production of IgG2c after in vitro TLR7 agonist stimulation. Our results demonstrate that Bank1 controls TLR7-mediated type I interferon production. Combined with the control of the nuclear translocation of IRF7, the modulation of STAT1 transcription and phosphorylation, Bank1 contributes to IgG production during development of autoimmune disease.

  6. BANK1 Regulates IgG Production in a Lupus Model by Controlling TLR7-Dependent STAT1 Activation

    Science.gov (United States)

    Iida, Ryuji; Bagavant, Harini; Alarcón-Riquelme, Marta E.

    2016-01-01

    The purpose of our study was to investigate the effects of the adaptor Bank1 in TLR7 signaling using the B6.Sle1.yaa mouse, a lupus model that develops disease through exacerbated TLR7 expression. Crosses of B6.Sle1.yaa with Bank1-/- mice maintained several B and myeloid cell phenotypes close to normal wild-type levels. Most striking was the reduction in total serum IgG antibodies, but not of IgM, and reduced serum levels of autoantibodies, IL-6, and BAFF. Bank1 deficiency did modify numbers of MZ B cells and total B cell numbers, as well as expression of CXCR4 by follicular helper T cells. Other T cell changes were not observed. Bank1 deficiency did not modify numbers of germinal center B cells or plasma cells or clinical disease outcomes. Purified B cells from Bank1 deficient mice had strongly reduced Ifnb, Ifna4, Irf7, Aicda and Stat1 gene expression following TLR7 agonist stimulation. Interestingly, phosphorylation of Tyr701, but not of Ser727 of STAT1, was impaired in splenic B cells from B6.Sle1.yaa.Bank1-/- mice, as was the nuclear translocation of IRF7 in response to TLR7 agonist stimulation. Further, Bank1 deficiency in B6.Sle1.yaa mice reduced the production of IgG2c after in vitro TLR7 agonist stimulation. Our results demonstrate that Bank1 controls TLR7-mediated type I interferon production. Combined with the control of the nuclear translocation of IRF7, the modulation of STAT1 transcription and phosphorylation, Bank1 contributes to IgG production during development of autoimmune disease. PMID:27228057

  7. Low TLR7 gene expression in atherosclerotic plaques is associated with major adverse cardio- and cerebrovascular events

    DEFF Research Database (Denmark)

    Karadimou, Glykeria; Folkersen, Lasse; Berg, Martin

    2016-01-01

    inhibitor. Immunofluorescent tissue analysis after TLR7 stimulation showed IL-10 expression in T cells, macrophages and vascular smooth muscle cells. TLR7 mRNA levels in the plaques were correlated with IL-10 receptor (r=0.4031, p....This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re...

  8. Plant Virus Particles Carrying Tumour Antigen Activate TLR7 and Induce High Levels of Protective Antibody

    Science.gov (United States)

    Jobsri, Jantipa; Allen, Alex; Rajagopal, Deepa; Shipton, Michael; Kanyuka, Kostya; Lomonossoff, George P.; Ottensmeier, Christian; Diebold, Sandra S.; Stevenson, Freda K.; Savelyeva, Natalia

    2015-01-01

    Induction of potent antibody is the goal of many vaccines targeted against infections or cancer. Modern vaccine designs that use virus-like particles (VLP) have shown efficacy for prophylactic vaccination against virus-associated cancer in the clinic. Here we used plant viral particles (PVP), which are structurally analogous to VLP, coupled to a weak idiotypic (Id) tumour antigen, as a conjugate vaccine to induce antibody against a murine B-cell malignancy. The Id-PVP vaccine incorporates a natural adjuvant, the viral ssRNA, which acts via TLR7. It induced potent protective anti-Id antibody responses in an in vivo mouse model, superior to the “gold standard” Id vaccine, with prevalence of the IgG2a isotype. Combination with alum further increased antibody levels and maintained the IgG2a bias. Engagement of TLR7 in vivo was followed by secretion of IFN-α by plasmacytoid dendritic cells and by activation of splenic CD11chi conventional dendritic cells. The latter was apparent from up-regulation of co-stimulatory molecules and from secretion of a wide range of inflammatory cytokines and chemokines including the Th1-governing cytokine IL-12, in keeping with the IgG2a antibody isotype distribution. PVP conjugates are a novel cancer vaccine design, offering an attractive molecular form, similar to VLP, and providing T-cell help. In contrast to VLP, they also incorporate a safe “in-built” ssRNA adjuvant. PMID:25692288

  9. TLR7 expression is decreased during tumour progression in transgenic adenocarcinoma of mouse prostate mice and its activation inhibits growth of prostate cancer cells.

    Science.gov (United States)

    Han, Ju-Hee; Park, Shin-Young; Kim, Jin-Bum; Cho, Sung-Dae; Kim, Bumseok; Kim, Bo-Yeon; Kang, Min-Jung; Kim, Dong-Jae; Park, Jae-Hak; Park, Jong-Hwan

    2013-10-01

    Although various Toll-like receptors (TLRs) have been associated with immune response and tumorigenesis in the prostate cells, little is known about the role of TLR7. Accordingly, we examined the expression of TLR7 during tumour progression of TRMAP (transgenic mouse model for prostate cancer) mice and its role on cell growth. Toll-like receptor7 expression was examined by RT-polymerase chain reaction (PCR), Western blot, and immunohistochemistry. Cell growth was examined by MTT assay. Colony formation was investigated by crystal violet staining. Strong expression of TLR7 was detected in the normal prostate epithelia of Wild-type (WT) mice, but not in TLR7-deficient mice. In contrast, TLR7 expression was weak in transgenic adenocarcinoma of mouse prostate (TRAMP)-C2 cells, as compared with murine bone marrow-derived macrophages (BMDMs). Moreover, TLR7 mRNA was markedly expressed in RWPE-1 cells (non-cancerous prostate epithelial cells), but not in PC3 and DU145 (prostate cancer cells). Immunohistochemically, TLR7 expression gradually decreased in TRAMP mice depending on the pathologic grade of the prostate cells. TLR7 agonists increased both the gene and protein expression of TLR7 and promoted production of proinflammatory cytokines/chemokines and IFN-β gene expression in prostate cancer cell lines. Moreover, loxoribine inhibited the growth and colony formation of TRAMP-C2 cells dependent of TLR7. These findings suggest that TLR7 may participate in tumour suppression in the prostate cells. © 2013 John Wiley & Sons Ltd.

  10. Sonography of the bicipitoradial bursa

    Science.gov (United States)

    Draghi, F.; Gregoli, B.; Sileo, C.

    2012-01-01

    Serous bursae consist of a synovial membrane enveloping a film of liquid. They are located at interfaces between moving structures where friction must be reduced. The bicipitoradial bursa lies between the distal tendon of the biceps brachii, which it surrounds, and the radial tuberosity. It is a relatively large bursa, with dimensions ranging from 2.4 to 3.9 cm. It sometimes presents septation. It does not communicate with the joint cavity, but it may communicate with the interosseous bursa of the elbow. Regardless of its cause, bicipitoradial bursitis presents as a mass in the cubital fossa and/or with neurological symptoms (sensorial and/or motorial) caused by compression of the radial nerve. On ultrasonography, the inflamed bursa is visualized as an anechoic formation surrounding the distal biceps tendon. In addition to its role in diagnosing the bursitis, sonography can provide information about radial nerve injury (in the presence of macroscopic damage), and it can also be used for guidance during intrabursal injections. PMID:23396577

  11. Imaging of bursae around the shoulder joint

    Energy Technology Data Exchange (ETDEWEB)

    Bureau, N.J. [Department of Radiology, Hotel-Dieu de Montreal Hospital, Montreal, Quebec (Canada); Dussault, R.G. [Department of Radiology, Health Sciences Center, University of Virginia, Charlottesville, Virginia (United States); Keats, T.E. [Department of Radiology, Health Sciences Center, University of Virginia, Charlottesville, Virginia (United States)

    1996-08-01

    The authors present a review of the anatomy of the major bursae around the shoulder joint and discuss the use of the different imaging modalities which demonstrate their radiologic features. The calcified subacromial-subdeltoid bursa has a characteristic appearance on plain radiographs. When inflamed it can be visualized by ultrasound and magnetic resonance imaging. Calcific bursitis may involve the subcoracoid bursa. This bursa may mimic adhesive capsulitis of the shoulder or complete rotator cuff tear when injected inadvertently during shoulder arthrography. Less well known are three coracoclavicular ligament bursae. These are also subject to calcific bursitis and have a typical radiologic appearance. (orig.). With 6 figs.

  12. The preparation and physico-chemical characterization of aluminum hydroxide/TLR7a, a novel vaccine adjuvant comprising a small molecule adsorbed to aluminum hydroxide.

    Science.gov (United States)

    Malyala, Padma; Laera, Donatello; Cianetti, Simona; Bufali, Simone; Aggravi, Marianna; Ianni, Elvira; Judge, Casey; Otten, Gillis; Singh, Manmohan; O' Hagan, Derek T

    2018-02-05

    Adjuvants are necessary to enable vaccine development against a significant number of challenging pathogens for which effective vaccines are not available [1]. We engineered a novel small-molecule immune potentiator (SMIP), a benzonaphthyridine agonist targeting toll-like receptor 7 (TLR7), as a vaccine adjuvant. TLR7 agonist (TLR7a) was engineered to be adsorbed onto aluminum hydroxide (AlOH), and the resulting AlOH/TLR7a was evaluated as a vaccine adjuvant [2-6]. AlOH/TLR7a exploits the flexibility of AlOH formulations, has an application in many vaccine candidates, and induced good efficacy and safety profiles against all tested antigens (bacterial- and viral-derived protein antigens, toxoids, glycoconjugates, etc.) in many animal models, including non-human primates [7]. In this paper, we describe the outcome of the physico-chemical characterization of AlOH/TLR7a. Reverse phase ultra-performance liquid chromatography (RP-UPLC), confocal microscopy, flow cytometry (FC), zeta potential (ZP) and phosphophilicity assays were used as tools to demonstrate the association of TLR7a to AlOH and to characterize this novel formulation. Raman spectroscopy, nuclear magnetic resonance and mass spectroscopy were also used to investigate the interaction between TLR7a and AlOH (data not shown). This pivotal work paved the way for AlOH/TLR7a to progress into the clinic for evaluation as an adjuvant platform for vaccines against challenging preventable diseases. Copyright © 2018. Published by Elsevier Inc.

  13. Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis

    Directory of Open Access Journals (Sweden)

    Greiff Lennart

    2012-06-01

    Full Text Available Abstract Background Interactions between Th1 and Th2 immune responses are of importance to the onset and development of allergic disorders. A Toll-like receptor 7 agonist such as AZD8848 may have potential as a treatment for allergic airway disease by skewing the immune system away from a Th2 profile. Objective To evaluate the efficacy and safety of intranasal AZD8848. Methods In a placebo-controlled single ascending dose study, AZD8848 (0.3-600 μg was given intranasally to 48 healthy subjects and 12 patients with allergic rhinitis (NCT00688779. In a placebo-controlled repeat challenge/treatment study, AZD8848 (30 and 60 μg was given once weekly for five weeks to 74 patients with allergic rhinitis out of season: starting 24 hours after the final dose, daily allergen challenges were given for seven days (NCT00770003. Safety, tolerability, pharmacokinetics, and biomarkers were monitored. During the allergen challenge series, nasal symptoms and lavage fluid levels of tryptase and α2-macroglobulin, reflecting mast cell activity and plasma exudation, were monitored. Results AZD8848 produced reversible blood lymphocyte reductions and dose-dependent flu-like symptoms: 30–100 μg produced consistent yet tolerable effects. Plasma interleukin-1 receptor antagonist was elevated after administration of AZD8848, reflecting interferon production secondary to TLR7 stimulation. At repeat challenge/treatment, AZD8848 reduced nasal symptoms recorded ten minutes after allergen challenge up to eight days after the final dose. Tryptase and α2-macroglobulin were also reduced by AZD8848. Conclusions Repeated intranasal stimulation of Toll-like receptor 7 by AZD8848 was safe and produced a sustained reduction in the responsiveness to allergen in allergic rhinitis. Trial registration NCT00688779 and NCT00770003 as indicated above.

  14. Baicalin inhibits TLR7/MYD88 signaling pathway activation to suppress lung inflammation in mice infected with influenza A virus

    Science.gov (United States)

    WAN, QIAOFENG; WANG, HAO; HAN, XUEBO; LIN, YUAN; YANG, YANHUI; GU, LIGANG; ZHAO, JIAQING; WANG, LI; HUANG, LING; LI, YANBIN; YANG, YURONG

    2014-01-01

    The present study aimed to investigate the protective effects and underlying mechanisms of baicalin on imprinting control region mice infected with influenza A/FM/1/47 (H1N1) virus. Oral administration of baicalin into mice infected with H1N1 prevented death, increased the mean time to death and inhibited lung index and lung consolidation. Subsequently, fluorescence quantitative polymerase chain reaction was used to assess the mRNA expression of toll-like receptor 7 (TLR7) and myeloid differentiation primary response gene 88 (MYD88), and western blot analysis was used to determine the expression of phosphorylated nuclear factor κB (NF-κB)-P65 and c-jun/activator protein 1 (AP-1). An enzyme-linked immunosorbent assay was applied to test for the inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-1β and IL-6, in the lung tissue. The findings indicated that baicalin downregulated the mRNA expression of TLR7 and MYD88, significantly downregulated the protein expression of NF-κB-P65 and AP-1 and also inhibited the secretion of TNF-α, IL-1β and IL-6. In conclusion, baicalin effectively reduced the pathological damage and inflammation of the lungs by downregulating the TLR7/MYD88-mediated signaling pathway. PMID:24748990

  15. Spontaneous Isolated Infection of the Subacromial Bursa

    Science.gov (United States)

    Al-Tawil, Karam

    2013-01-01

    Isolated infection of the subacromial bursa is a rare entity. We present the case of a previously fit man who was found to have staphylococcal infection of the sub-acromial bursa, without an obvious precipitant. Preoperative MRI scanning determined the specific locus of infection, and the patient was successfully treated with arthroscopic washout of the sub-acromial bursa followed by empirical antibiotic therapy. PMID:23984140

  16. Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico.

    Science.gov (United States)

    Pacheco, Guillermo Valencia; Cruz, Darig Cámara; González Herrera, Lizbeth J; Pérez Mendoza, Gerardo J; Adrián Amaro, Guadalupe I; Nakazawa Ueji, Yumi E; Angulo Ramírez, Angélica V

    2014-01-01

    Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the production of autoantibodies against self-antigens, which occurs most often in women between 15 and 40 years of age. The innate immunity is involved in the pathogenesis of SLE through TLR- 7. Genetic factors such as copy number variation (CNV) of target genes may contribute to disease development, but this possible risk has not yet been studied in SLE patients from Yucatan, Mexico. The CNV of TLR-7 gene was determined by quantitative polymerase chain reaction assay using TaqMan probes in 80 SLE women and 150 control subjects. The results showed that 10% of SLE patients exhibited more than two copies of TLR-7 gene, whereas no mRNA overexpression was detected. These data suggested that increased CNV of the TLR-7 gene in Yucatan SLE women can be a risk factor for this disease.

  17. TLR7 Gln11Leu single nucleotide polymorphism and response to treatment with imiquimod in patients with basal cell carcinoma: a pilot study.

    Science.gov (United States)

    Piaserico, Stefano; Michelotto, Anna; Frigo, Anna C; Alaibac, Mauro

    2015-11-01

    The Toll-like receptor 7 (TLR7) agonist, imiquimod, offers a topical and noninvasive therapeutic method for the clinical treatment of superficial basal cell carcinoma (BCC). In this study we explored the relationship between the functional X-linked TLR7 rs179008/Gln11Leu polymorphism and the response to imiquimod in patients with BCC. Thirty-four BCC patients treated with imiquimod were included in the study. SNP genotyping of the TLR7 promoter polymorphism was performed by TaqMan allelic discrimination assay. In the group of female nonresponders to imiquimod a higher frequency of the altered genotype compared with responders was observed. Similarly, in the group of male nonresponders to imiquimod both patients with the mutated genotype were nonresponders. The results of this study show that patients carrying at least one T allele of the TLR7 promoter polymorphism are associated with an increased probability to be resistant to imiquimod therapy.

  18. Expression of TLR-7, MyD88, NF-kB and INF-α in B lymphocytes of Mayan Women with Systemic Lupus Erythematosus, in Mexico

    Directory of Open Access Journals (Sweden)

    Guillermo eValencia Pacheco

    2016-02-01

    Full Text Available Background: Systemic Lupus Erythematosus (SLE is a chronic inflammatory autoimmune disease involving multiple organs. It is currently accepted that several genetic, environmental, and hormonal factors contributing to its development. Innate immunity may have a great influence in autoimmunity through Toll-like receptors (TLR. TLR-7 recognizing single-strand RNA has been involved in SLE. Its activation induces intracellular signal with attraction of MyD88 and NF-kB, leading to IFN-α synthesis which correlate with disease activity. Objective: To assess the expression of TLR-7, MyD88 and NF-kB in mononuclear cells of Mayan women with SLE. Methods: One hundred patients with SLE and one hundred healthy controls, all them Mayan women, were included. TLR-7 was analyzed on B and T lymphocytes, and MyD88 and NF-kB only in B lymphocytes. Serum INF-α level was evaluated by ELISA. Results: Significant expression (p < 0.0001 of TLR-7 in B and T lymphocytes and serum IFN-α increased (p = 0.034 was observed in patients. MyD88 and NF-kB were also increased in B lymphocytes of patients. TLR-7 and NF-kB expression correlated, but no correlation with INF-α and disease activity was detected. Conclusion: Data support the role of TLR-7 and signal proteins in the pathogenesis of SLE in the Mayan population of Yucatán.

  19. Interferon-alpha suppressed granulocyte colony stimulating factor production is reversed by CL097, a TLR7/8 agonist.

    LENUS (Irish Health Repository)

    Tajuddin, Tariq

    2012-02-01

    BACKGROUND AND AIM: Neutropenia, a major side-effect of interferon-alpha (IFN-alpha) therapy can be effectively treated by the recombinant form of granulocyte colony stimulating factor (G-CSF), an important growth factor for neutrophils. We hypothesized that IFN-alpha might suppress G-CSF production by peripheral blood mononuclear cells (PBMCs), contributing to the development of neutropenia, and that a toll-like receptor (TLR) agonist might overcome this suppression. METHODS: Fifty-five patients who were receiving IFN-alpha\\/ribavirin combination therapy for chronic hepatitis C virus (HCV) infection were recruited. Absolute neutrophil counts (ANC), monocyte counts and treatment outcome data were recorded. G-CSF levels in the supernatants of PBMCs isolated from the patients and healthy controls were assessed by enzyme-linked immunosorbent assay following 18 h of culture in the absence or presence of IFN- alpha or the TLR7\\/8 agonist, CL097. RESULTS: Therapeutic IFN-alpha caused a significant reduction in neutrophil counts in all patients, with 15 patients requiring therapeutic G-CSF. The reduction in ANC over the course of IFN-alpha treatment was paralleled by a decrease in the ability of PBMCs to produce G-CSF. In vitro G-CSF production by PBMCs was suppressed in the presence of IFN-alpha; however, co-incubation with a TLR7\\/8 agonist significantly enhanced G-CSF secretion by cells obtained both from HCV patients and healthy controls. CONCLUSIONS: Suppressed G-CSF production in the presence of IFN-alpha may contribute to IFN-alpha-induced neutropenia. However, a TLR7\\/8 agonist elicits G-CSF secretion even in the presence of IFN-alpha, suggesting a possible therapeutic role for TLR agonists in treatment of IFN-alpha-induced neutropenia.

  20. Magnetic resonance imaging of navicular bursa adhesions.

    Science.gov (United States)

    Holowinski, Maureen E; Solano, Mauricio; Maranda, Louise; García-López, José M

    2012-01-01

    Adhesions occur in the navicular bursa between the deep digital flexor tendon (DDFT) and other structures. Our objectives were to describe the appearance of navicular bursa adhesions on high-field magnetic resonance (MR) images, to compare these findings to findings at navicular bursoscopy, and to determine the prevalence of lesions in the remainder of the podotrochlear apparatus. Sixteen forelimbs from 14 horses that underwent MR imaging and navicular bursoscopy were evaluated. Adhesions were considered type 1 when characterized by a discontinuity in the navicular bursa fluid signal between two structures, type 2 when the navicular bursa fluid signal was disrupted and ill-defined tissue was present between two structures, and type 3 when the fluid signal was disrupted and well-defined tissue was present between two structures. Twenty-six adhesions were suspected on MR images and nineteen were visualized at surgery. The positive predictive value was 50% for type 1 adhesions, 67% for type 2 adhesions, and 100% for type 3 adhesions. Additional lesions were detected in the navicular bursa in 15 limbs, the DDFT in 13, the navicular bone in 15, the collateral sesamoidean ligaments in 9, and the distal sesamoidean impar ligament in 8. A discontinuity in the navicular bursa fluid signal with well-defined tissue between two structures detected on high-field MR images is diagnostic for a navicular bursa adhesion. Additional lesions in the podotrochlear apparatus are common in horses with navicular bursa adhesions. © 2012 Veterinary Radiology & Ultrasound.

  1. Kesan Anomali Bermusim Terhadap Bursa Malaysia

    OpenAIRE

    Nurfadhlina Binti Abdul Halim; How Teng Ying; Wan Muhamad Amir Bin Wan Ahmad

    2014-01-01

    Kajian ini mengkaji sama ada Bursa Malaysia adalah efisien dalam bentuk lemah. Penemuan kewujudan anomali bermusim iaitu kesan Januari atau bulanan dan kesan harian akan menolak hipotesis pasaran efisien bentuk lemah. Analisis regresi siri masa digunakan untuk menentukan kewujudan anomali bermusim dalam Indeks Komposit Bursa Malaysia dari tahun 1999 sehingga tahun 2006.

  2. Modulation of Murine Macrophage TLR7/8-Mediated Cytokine Expression by Mesenchymal Stem Cell-Conditioned Medium

    OpenAIRE

    Asami, Takahiro; Ishii, Makoto; Fujii, Hideki; Namkoong, Ho; Tasaka, Sadatomo; Matsushita, Kenichi; Ishii, Ken; Yagi, Kazuma; Fujiwara, Hiroshi; Funatsu, Yohei; Hasegawa, Naoki; Betsuyaku, Tomoko

    2013-01-01

    Increasing evidence suggests that mesenchymal stem cells (MSCs) play anti-inflammatory roles during innate immune responses. However, little is known about the effect of MSCs or their secretions on the ligand response of Toll-like receptor (TLR) 7 and TLR8, receptors that recognize viral single-stranded RNA (ssRNA). Macrophages play a critical role in the innate immune response to ssRNA virus infection; therefore, we investigated the effect of MSC-conditioned medium on cytokine expression in ...

  3. Co-expression of march5b and tlr7 in large yellow croaker Larimichthys crocea in response to Cryptocaryon irritans infection.

    Science.gov (United States)

    Zhang, D L; Yu, D H; Chen, J; Chen, C; Wang, Z Y

    2015-08-01

    In this study, molecular characteristics of march5b and co-expression of march5b and tlr7 in response to the infection of Cryptocaryon irritans in the large yellow croaker Larimichthys crocea were investigated. The full-length complementary (c)DNA of march5b was 1314 bp, including an open reading frame of 846 bp encoding a polypeptide of 281 amino acids, and the full-length genomic sequence was composed of 23,577 nucleotides, including six exons and five introns. The putative March5b protein contained a RINGv motif and four transmembrane domains. The march5b transcripts were broadly distributed in all detected tissues, with a strong expression in blood, brain and gills, and a weak expression in kidney by quantitative PCR analysis. The expression of march5b and tlr7 in the skin, gills, spleen and head kidney changed in the same manner at most time points post-primary infection with C. irritans. Significant increase was observed in the skin with march5b at days 2 and 3 by 26.10 and 6.88 fold, respectively, and with tlr7 at day 3 by 57.68 fold, when compared with the control. Their expressions, however, were decreased in the gills, especially at day 3 (march5b by 8.9%, tlr7 by 22.06%). In the spleen and head kidney, march5b and tlr7 transcripts were up-regulated early, then noticeably declined at day 3. These results suggested that march5b and tlr7 are co-expressed in response to parasite infection and March5b probably catalyses ubiquitination of some proteins of TLR7 signalling pathway. © 2015 The Fisheries Society of the British Isles.

  4. Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.

    Science.gov (United States)

    Khan, Adnan R; Amu, Sylvie; Saunders, Sean P; Hams, Emily; Blackshields, Gordon; Leonard, Martin O; Weaver, Casey T; Sparwasser, Tim; Sheils, Orla; Fallon, Padraic G

    2015-06-01

    B cells have been described as having the capacity to regulate cellular immune responses and suppress inflammatory processes. One such regulatory B-cell population is defined as IL-10-producing CD19(+) CD1d(hi) cells. Previous work has identified an expansion of these cells in mice infected with the helminth, Schistosoma mansoni. Here, microarray analysis of CD19(+) CD1d(hi) B cells from mice infected with S. mansoni demonstrated significantly increased Tlr7 expression, while CD19(+) CD1d(hi) B cells from uninfected mice also demonstrated elevated Tlr7 expression. Using IL-10 reporter, Il10(-/-) and Tlr7(-/-) mice, we formally demonstrate that TLR7 ligation of CD19(+) CD1d(hi) B cells increases their capacity to produce IL-10. In a mouse model of allergic lung inflammation, the adoptive transfer of TLR7-elicited CD19(+) CD1d(hi) B cells reduced airway inflammation and associated airway hyperresponsiveness. Using DEREG mice to deplete FoxP3(+) T regulatory cells in allergen-sensitized mice, we show that that TLR7-elicited CD19(+) CD1d(hi) B cells suppress airway hyperresponsiveness via a T regulatory cell dependent mechanism. These studies identify that TLR7 stimulation leads to the expansion of IL-10-producing CD19(+) CD1d(hi) B cells, which can suppress allergic lung inflammation via T regulatory cells. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Identification, characterization and genetic mapping of TLR7, TLR8a1 and TLR8a2 genes in rainbow trout (Oncorhynchus mykiss)

    Science.gov (United States)

    Palti, Yniv; Gahr, Scott A.; Purcell, Maureen K.; Hadidi, Sima; Rexroad, Caird E.; Wiens, Gregory A.

    2010-01-01

    Induction of the innate immune pathways is critical for early anti-viral defense but there is limited understanding of how teleost fish recognize viral molecules and activate these pathways. In mammals, Toll-like receptors (TLR) 7 and 8 bind single-stranded RNA of viral origin and are activated by synthetic anti-viral imidazoquinoline compounds. Herein, we identify and describe the rainbow trout (Oncorhynchus mykiss) TLR7 and TLR8 gene orthologs and their mRNA expression. Two TLR7/8 loci were identified from a rainbow trout bacterial artificial chromosome (BAC) library using DNA fingerprinting and genetic linkage analyses. Direct sequencing of two representative BACs revealed intact omTLR7 and omTLR8a1 open reading frames (ORFs) located on chromosome 3 and a second locus on chromosome 22 that contains an omTLR8a2 ORF and a putative TLR7 pseudogene. We used the omTLR8a1/2 nomenclature for the two trout TLR8 genes as phylogenetic analysis revealed that they and all the other teleost TLR8 genes sequenced to date are similar to the zebrafish TLR8a, but are distinct from the zebrafish TLR8b. The duplicated trout loci exhibit conserved synteny with other fish genomes extending beyond the tandem of TLR7/8 genes. The trout TLR7 and 8a1/2 genes are composed of a single large exon similar to all other described TLR7/8 genes. The omTLR7 ORF is predicted to encode a 1049 amino acid (aa) protein with 84% similarity to the Fugu TLR7 and a conserved pattern of predicted leucine-rich repeats (LRR). The omTLR8a1 and omTLR8a2 are predicted to encode 1035- and 1034-aa proteins, respectively, and have 86% similarity to each other. omTLR8a1 is likely the ortholog of the only Atlantic salmon TLR8 gene described to date as they have 95% aa sequence similarity. The tissue expression profiles of omTLR7, omTLR8a1 and omTLR8a2 in healthy trout were highest in spleen tissue followed by anterior and then posterior kidney tissues. Rainbow trout anterior kidney leukocytes produced elevated

  6. IN VITRO INTERACTION OF INFLUENZA VIRUS A(H1N1pdm09 WITH MONOCYTIC MACROPHAGES: INDIVIDUAL RESPONSES OF TLR7 AND RIG1 RECEPTOR GENES

    Directory of Open Access Journals (Sweden)

    T. M. Sokolova

    2017-01-01

    Full Text Available In vitro differentiation of donor blood monocytes to macrophages (Mph following GM-CSF treatment was accompanied by a significant increase in the levels of gene transcription signaling receptors TLR7 or RIG1. The levels of intracellular viral RNA (M1 gene in Mph remained high upon infection by influenza virus A H1N1pdm (Moscow 2009 for 24-96 hours. The innate immunity reactions caused by influenza virus show individual features: they are decreased in Mph from donor 1 which had initially high level of endosomal TLR7 gene activity, and it increased by influenza virus in MPh from donor 2 who had a very low level of TLR7 gene expression. The influenza H1N1pdm virus weakly stimulated expression of gene RIG1 and production of inflammatory cytokines in Mf in donor 1. The differences may be connected with individual sensitivity of the donors to influenza infection.

  7. Critical role of TLR7 signaling in the priming of cross-protective cytotoxic T lymphocyte responses by a whole inactivated influenza virus vaccine.

    Directory of Open Access Journals (Sweden)

    Natalija Budimir

    Full Text Available Current influenza vaccines fail to induce protection against antigenically distinct virus strains. Accordingly, there is a need for the development of cross-protective vaccines. Previously, we and others have shown that vaccination with whole inactivated virus (WIV induces cross-protective cellular immunity in mice. To probe the mechanistic basis for this finding, we investigated the role of TLR7, a receptor for single-stranded RNA, in induction of cross-protection. Vaccination of TLR7-/- mice with influenza WIV failed to protect against a lethal heterosubtypic challenge; in contrast, wild-type mice were fully protected. The lack of protection in TLR7-/- mice was associated with high viral load and a relative paucity of influenza-specific CD8+ cytotoxic T lymphocyte (CTL responses. Dendritic cells (DCs from TLR7-/- mice were unable to cross-present WIV-derived antigen to influenza-specific CTLs in vitro. Similarly, TLR7-/- DCs failed to mature and become activated in response to WIV, as determined by the assessment of surface marker expression and cytokine production. Plasmacytoid DCs (pDCs derived from wild-type mice responded directly to WIV while purified conventional DCs (cDCs did not respond to WIV in isolation, but were responsive in mixed pDC/cDC cultures. Depletion of pDCs prior to and during WIV immunization resulted in reduced numbers of influenza-specific CTLs and impaired protection from heterosubtypic challenge. Thus, TLR7 plays a critical role in the induction of cross-protective immunity upon vaccination with WIV. The initial target cells for WIV appear to be pDCs which by direct or indirect mechanisms promote activation of robust CTL responses against conserved influenza epitopes.

  8. Primary synovial osteochondromatosis of a subdeltoid bursa.

    Science.gov (United States)

    Kumar, Anil; Aggarwal, Arvind; Sahni, Virender K

    2010-01-01

    Primary synovial osteochondromatosis (SOC) is known to be intra-articular and wherever it is observed outside a synovial joint, it is associated with the involvement of the nearby joint. Primary SOC has not been reported to involve a subdeltoid bursa. We present a case of a 52-year-old woman having a large number of loose bodies in a large tumor in the subdeltoid bursa. The swelling was first noticed by the patient 2 years back. Plain roentgenogram revealed soft tissue swelling only with no areas of calcification. On MRI, multiple nonosseous loose bodies were visualized in the bursa deep to the deltoid muscle. A surgical excision of subdeltoid bursa was done. A biopsy confirmed it to be cartilaginous loose bodies in synovial lining sugestive of metaplastic transformation of the synovial tissue.

  9. Kesan Anomali Bermusim Terhadap Bursa Malaysia

    National Research Council Canada - National Science Library

    Nurfadhlina Binti Abdul Halim; How Teng Ying; Wan Muhamad Amir Bin Wan Ahmad

    2014-01-01

    Kajian ini mengkaji sama ada Bursa Malaysia adalah efisien dalam bentuk lemah. Penemuan kewujudan anomali bermusim iaitu kesan Januari atau bulanan dan kesan harian akan menolak hipotesis pasaran efisien bentuk lemah...

  10. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction

    OpenAIRE

    Uematsu, Satoshi; Sato, Shintaro; Yamamoto, Masahiro; Hirotani, Tomonori; Kato, Hiroki; Takeshita, Fumihiko; Matsuda, Michiyuki; Coban, Cevayir; Ishii, Ken J.; Kawai, Taro; Takeuchi, Osamu; Akira, Shizuo

    2005-01-01

    Toll-like receptors (TLRs) recognize microbial pathogens and trigger innate immune responses. Among TLR family members, TLR7, TLR8, and TLR9 induce interferon (IFN)-α in plasmacytoid dendritic cells (pDCs). This induction requires the formation of a complex consisting of the adaptor MyD88, tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) and IFN regulatory factor (IRF) 7. Here we show an essential role of IL-1 receptor-associated kinase (IRAK)-1 in TLR7- and TLR9-mediated IRF7...

  11. TLR-7 agonist attenuates airway reactivity and inflammation through Nrf2-mediated antioxidant protection in a murine model of allergic asthma.

    Science.gov (United States)

    Nadeem, Ahmed; Siddiqui, Nahid; Al-Harbi, Naif O; Al-Harbi, Mohammed M; Ahmad, Sheikh F

    2016-04-01

    Toll-like receptors (TLRs) through innate immune system recognize pathogen associated molecular patterns and play an important role in host defense against bacteria, fungi and viruses. TLR-7 is responsible for sensing single stranded nucleic acids of viruses but its activation has been shown to be protective in mouse models of asthma. The NADPH oxidase (NOX) enzymes family mainly produces reactive oxygen species (ROS) in the lung and is involved in regulation of airway inflammation in response to TLRs activation. However, NOX-4 mediated signaling in response to TLR-7 activation in a mouse model of allergic asthma has not been explored previously. Therefore, this study investigated the role TLR-7 activation and downstream oxidant-antioxidant signaling in a murine model of asthma. Mice were sensitized with ovalbumin (OVA) intraperitoneally and treated with TLR-7 agonist, resiquimod (RSQ) intranasally before each OVA challenge from days 14 to 16. Mice were then assessed for airway reactivity, inflammation, and NOX-4 and nuclear factor E2-related factor 2 (Nrf2) related signaling [inducible nitric oxide synthase (iNOS), nitrotyrosine, lipid peroxides and copper/zinc superoxide dismutase (Cu/Zn SOD)]. Treatment with RSQ reduced allergen induced airway reactivity and inflammation. This was paralleled by a decrease in ROS which was due to induction of Nrf2 and Cu/Zn SOD in RSQ treated group. Inhibition of MyD88 reversed RSQ-mediated protective effects on airway reactivity/inflammation due to reduction in Nrf2 signaling. SOD inhibition produced effects similar to MyD88 inhibition. The current study suggests that TLR-7 agonist is beneficial and may be developed into a therapeutic option in allergic asthma. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. The existence of cords in olecranon bursae.

    Science.gov (United States)

    Ecker, Jeff; Ebert, Jay R; Taheri, Arash; Mathew, Ravi K; Chee, Derserri Y; Breidahl, William

    2015-10-01

    The purpose of this study was to document the existence of transverse cords in olecranon bursae in patients undergoing excision of the bursa and to describe the unique clinical presentation of patients with these cords. A retrospective study was performed on 24 patients who had surgery to excise an olecranon bursa between 2006 and 2011. The patient's history, preoperative radiographs, ultrasound images, intraoperative photographs, and findings on histologic analysis were reviewed in all cases. Nine olecranon bursae had cords (cord group) and 15 did not have cords (noncord group). All patients in the cord group were male manual laborers, and nearly all had olecranon enthesophytes (n = 8). Patients in the noncord group had associated medical conditions or an infection. A higher level of satisfaction was reported in the noncord group after surgical excision. This study documents the existence of transverse cords oriented at right angles to the long axis of the olecranon. Olecranon bursae with cords have a unique presentation and are found in male manual workers, are nearly always associated with an olecranon enthesophyte, and do not present with infections. Copyright © 2015 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

  13. Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus

    Science.gov (United States)

    Bagnoli, Fabio; Fontana, Maria Rita; Soldaini, Elisabetta; Mishra, Ravi P. N.; Fiaschi, Luigi; Cartocci, Elena; Nardi-Dei, Vincenzo; Ruggiero, Paolo; Nosari, Sarah; De Falco, Maria Grazia; Lofano, Giuseppe; Marchi, Sara; Galletti, Bruno; Mariotti, Paolo; Bacconi, Marta; Torre, Antonina; Maccari, Silvia; Scarselli, Maria; Rinaudo, C. Daniela; Inoshima, Naoko; Savino, Silvana; Mori, Elena; Rossi-Paccani, Silvia; Baudner, Barbara; Pallaoro, Michele; Swennen, Erwin; Petracca, Roberto; Brettoni, Cecilia; Liberatori, Sabrina; Norais, Nathalie; Monaci, Elisabetta; Bubeck Wardenburg, Juliane; Schneewind, Olaf; O’Hagan, Derek T.; Valiante, Nicholas M.; Bensi, Giuliano; Bertholet, Sylvie; De Gregorio, Ennio; Rappuoli, Rino; Grandi, Guido

    2015-01-01

    Both active and passive immunization strategies against Staphylococcus aureus have thus far failed to show efficacy in humans. With the attempt to develop an effective S. aureus vaccine, we selected five conserved antigens known to have different roles in S. aureus pathogenesis. They include the secreted factors α-hemolysin (Hla), ess extracellular A (EsxA), and ess extracellular B (EsxB) and the two surface proteins ferric hydroxamate uptake D2 and conserved staphylococcal antigen 1A. The combined vaccine antigens formulated with aluminum hydroxide induced antibodies with opsonophagocytic and functional activities and provided consistent protection in four mouse models when challenged with a panel of epidemiologically relevant S. aureus strains. The importance of antibodies in protection was demonstrated by passive transfer experiments. Furthermore, when formulated with a toll-like receptor 7-dependent (TLR7) agonist recently designed and developed in our laboratories (SMIP.7–10) adsorbed to alum, the five antigens provided close to 100% protection against four different staphylococcal strains. The new formulation induced not only high antibody titers but also a Th1 skewed immune response as judged by antibody isotype and cytokine profiles. In addition, low frequencies of IL-17–secreting T cells were also observed. Altogether, our data demonstrate that the rational selection of mixtures of conserved antigens combined with Th1/Th17 adjuvants can lead to promising vaccine formulations against S. aureus. PMID:25775551

  14. TLR7/TLR8 Activation Restores Defective Cytokine Secretion by Myeloid Dendritic Cells but Not by Plasmacytoid Dendritic Cells in HIV-Infected Pregnant Women and Newborns.

    Science.gov (United States)

    Cardoso, Elaine Cristina; Pereira, Nátalli Zanete; Mitsunari, Gabrielle Eimi; Oliveira, Luanda Mara da Silva; Ruocco, Rosa Maria S A; Francisco, Rossana Pulcineli Vieira; Zugaib, Marcelo; da Silva Duarte, Alberto José; Sato, Maria Notomi

    2013-01-01

    Mother-to-child transmission (MTCT) of HIV-1 has been significantly reduced with the use of antiretroviral therapies, resulting in an increased number of HIV-exposed uninfected infants. The consequences of HIV infection on the innate immune system of both mother-newborn are not well understood. In this study, we analyzed peripheral blood and umbilical cord blood (CB) collected from HIV-1-infected and uninfected pregnant women. We measured TNF-α, IL-10 and IFN-α secretion after the stimulation of the cells with agonists of both extracellular Toll-like receptors (TLRs) (TLR2, TLR4 and TLR5) and intracellular TLRs (TLR7, TLR7/8 and TLR9). Moreover, as an indicator of the innate immune response, we evaluated the responsiveness of myeloid dendritic cells (mDCs) and plasmacytoid DCs (pDCs) to TLRs that are associated with the antiviral response. Our results showed that peripheral blood mononuclear cells (PBMCs) from HIV-1-infected mothers and CB were defective in TNF-α production after activation by TLR2, TLR5, TLR3 and TLR7. However, the TNF-α response was preserved after TLR7/8 (CL097) stimulation, mainly in the neonatal cells. Furthermore, only CL097 activation was able to induce IL-10 and IFN-α secretion in both maternal and CB cells in the infected group. An increase in IFN-α secretion was observed in CL097-treated CB from HIV-infected mothers compared with control mothers. The effectiveness of CL097 stimulation was confirmed by observation of similar mRNA levels of interferon regulatory factor-7 (IRF-7), IFN-α and TNF-α in PBMCs of both groups. The function of both mDCs and pDCs was markedly compromised in the HIV-infected group, and although TLR7/TLR8 activation overcame the impairment in TNF-α secretion by mDCs, such stimulation was unable to reverse the dysfunctional type I IFN response by pDCs in the HIV-infected samples. Our findings highlight the dysfunction of innate immunity in HIV-infected mother-newborn pairs. The activation of the TLR7/8 pathway

  15. SARS Coronavirus Papain-Like Protease Inhibits the TLR7 Signaling Pathway through Removing Lys63-Linked Polyubiquitination of TRAF3 and TRAF6.

    Science.gov (United States)

    Li, Shih-Wen; Wang, Ching-Ying; Jou, Yu-Jen; Huang, Su-Hua; Hsiao, Li-Hsin; Wan, Lei; Lin, Ying-Ju; Kung, Szu-Hao; Lin, Cheng-Wen

    2016-05-05

    Severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLPro) reportedly inhibits the production of type I interferons (IFNs) and pro-inflammatory cytokines in Toll-like receptor 3 (TLR3) and retinoic acid-inducible gene 1 (RIG-I) pathways. The study investigated the inhibitory effect and its antagonistic mechanism of SARS-CoV PLPro on TLR7-mediated cytokine production. TLR7 agonist (imiquimod (IMQ)) concentration-dependently induced activation of ISRE-, NF-κB- and AP-1-luciferase reporters, as well as the production of IFN-α, IFN-β, TNF-α, IL-6 and IL-8 in human promonocyte cells. However, SARS-CoV PLPro significantly inhibited IMQ-induced cytokine production through suppressing the activation of transcription factors IRF-3, NF-κB and AP-1. Western blot analysis with anti-Lys48 and anti-Lys63 ubiquitin antibodies indicated the SARS-CoV PLPro removed Lys63-linked ubiquitin chains of TRAF3 and TRAF6, but not Lys48-linked ubiquitin chains in un-treated and treated cells. The decrease in the activated state of TRAF3 and TRAF6 correlated with the inactivation of TBK1 in response to IMQ by PLPro. The results revealed that the antagonism of SARS-CoV PLPro on TLR7-mediated innate immunity was associated with the negative regulation of TRAF3/6-TBK1-IRF3/NF-κB/AP1 signals.

  16. A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells.

    Science.gov (United States)

    Cheadle, E J; Lipowska-Bhalla, G; Dovedi, S J; Fagnano, E; Klein, C; Honeychurch, J; Illidge, T M

    2017-07-01

    Anti-CD20 monoclonal antibodies (mAb) such as rituximab have been proven to be highly effective at improving outcome in B-cell malignancies. However, many patients ultimately relapse and become refractory to treatment. The glycoengineered anti-CD20 mAb obinutuzumab was developed to induce enhanced antibody-dependent cellular cytotoxicity, antibody-dependent phagocytosis and direct cell death and was shown to lead to improved outcomes in a randomized study in B-CLL. We hypothesized that immune stimulation through Toll-like receptor 7 (TLR7) agonism in combination with obinutuzumab would further enhance lymphoma clearance and the generation of long-term antitumor immune responses. Here we demonstrate, in syngeneic human CD20 (hCD20)-expressing models of lymphoma, that systemic administration of a TLR7 agonist (R848) increases responses when administered in combination with obinutuzumab and protects against disease recurrence. Depletion studies demonstrate that primary antitumor activity is dependent on both NK cells and CD4(+) T cells but not on CD8(+) T cells. However, both CD4(+) and CD8(+) T cells appear necessary for the generation of protective immunological memory. Importantly, increased tumor-free survival post obinutuzumab and R848 combination therapy was seen in hCD20 transgenic mice, which express hCD20 on normal B cells. These findings provide a rationale for clinical testing of obinutuzumab in combination with systemically administered TLR7 agonists to further improve outcome.

  17. Expression of TLR-7, MyD88, NF-kB, and INF-α in B Lymphocytes of Mayan Women with Systemic Lupus Erythematosus in Mexico.

    Science.gov (United States)

    Pacheco, Guillermo Valencia; Novelo Noh, Irene B; Velasco Cárdenas, Rubí M-H; Angulo Ramírez, Angélica V; López Villanueva, Ricardo F; Quintal Ortiz, Irma G; Alonso Salomón, Ligia G; Ruz, Norma Pavía; Rivero Cárdenas, Nubia A

    2016-01-01

    Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease involving multiple organs. It is currently accepted that several genetic, environmental, and hormonal factors are contributing to its development. Innate immunity may have a great influence in autoimmunity through Toll-like receptors. TLR-7 recognizing single-strand RNA has been involved in SLE. Its activation induces intracellular signal with attraction of MyD88 and NF-kBp65, leading to IFN-α synthesis which correlate with disease activity. To assess the expression of TLR-7, MyD88, and NF-kBp65 in B lymphocytes of Mayan women with SLE. One hundred patients with SLE and 100 healthy controls, all of them Mayan women, were included. TLR-7 was analyzed on B and T lymphocytes, and MyD88 and NF-kB only in B lymphocytes. Serum INF-α level was evaluated by ELISA. Significant expression (p Mayan population of Yucatán.

  18. Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice.

    Science.gov (United States)

    Goff, Peter H; Hayashi, Tomoko; He, Wenqian; Yao, Shiyin; Cottam, Howard B; Tan, Gene S; Crain, Brian; Krammer, Florian; Messer, Karen; Pu, Minya; Carson, Dennis A; Palese, Peter; Corr, Maripat

    2017-10-01

    We previously demonstrated that the combination of synthetic small-molecule Toll-like receptor 4 (TLR4) and TLR7 ligands is a potent adjuvant for recombinant influenza virus hemagglutinin, inducing rapid and sustained immunity that is protective against influenza viruses in homologous, heterologous, and heterosubtypic murine challenge models. Combining the TLR4 and TLR7 ligands balances Th1 and Th2-type immune responses for long-lived cellular and neutralizing humoral immunity against the viral hemagglutinin. Here, we demonstrate that the protective response induced in mice by this combined adjuvant is dependent upon TLR4 and TLR7 signaling via myeloid differentiation primary response gene 88 (MyD88), indicating that the adjuvants function in vivo via their known receptors, with negligible off-target effects, to induce protective immunity. The combined adjuvant acts via MyD88 in both bone marrow-derived and non-bone marrow-derived radioresistant cells to induce hemagglutinin-specific antibodies and protect mice against influenza virus challenge. The protective efficacy generated by immunization with this adjuvant and recombinant hemagglutinin antigen is transferable with serum from immunized mice to recipient mice in a homologous, but not a heterologous, H1N1 viral challenge model. Depletion of CD4+ cells after an established humoral response in immunized mice does not impair protection from a homologous challenge; however, it does significantly impair recovery from a heterologous challenge virus, highlighting an important role for vaccine-induced CD4+ cells in cross-protective vaccine efficacy. The combination of the two TLR agonists allows for significant dose reductions of each component to achieve a level of protection equivalent to that afforded by either single agent at its full dose.IMPORTANCE Development of novel adjuvants is needed to enhance immunogenicity to provide better protection from seasonal influenza virus infection and improve pandemic

  19. Chest wall ectopic synovial bursa cyst.

    Science.gov (United States)

    Michail, P; Filis, C; Pikoulis, E; Varelas, P; Kyrochristos, D; Mihail, S; Bastounis, E

    1999-11-01

    We report an unusual case of chest wall tumor in a 27-year-old patient. A complete resection was accomplished, and the patient had an excellent postoperative course. Histologically, the mass was confirmed to be an ectopic synovial bursa cyst. Although rare, synovial cysts should be considered in any case of a fluctuating chest wall mass. We also discuss the etiology and diagnostic approach of cystic masses of the chest wall.

  20. Complications following resection of the olecranon bursa.

    Science.gov (United States)

    Degreef, Ilse; De Smet, Luc

    2006-08-01

    We retrospectively reviewed 37 cases of resection of the olecranon bursa and noted wound healing problems in 10 (27%) and recurrence in 8 (22%). A lateral arm flap was necessary in one patient. Conservative treatment remains the treatment of choice for olecranon bursitis. Differentiation between septic and non-septic cases is challenging. The risk of wound healing problems and recurrence should be taken into account when planning surgical resection.

  1. Ultrasound evaluation of bursae: anatomy and pathological appearances.

    Science.gov (United States)

    Ruangchaijatuporn, Thumanoon; Gaetke-Udager, Kara; Jacobson, Jon A; Yablon, Corrie M; Morag, Yoav

    2017-04-01

    A bursa is an extra-articular sac that may communicate with a joint and functions to decrease friction between tendons and either bone or skin. Bursae can be classified as native and non-native (adventitious) bursae. The native bursae are lined with a synovial membrane and occur at predictable anatomical sites; knowledge of these normal structures can help distinguish them from other pathological entities. An adventitious bursa can form at sites of friction rather than at predictable anatomical sites, but otherwise have imaging features similar to native bursae. Bursal distention can occur from many pathological processes, most commonly resulting from chronic overuse injury. When imaging bursal pathological conditions, there is often an overlap of imaging findings, regardless of the cause. In general, ultrasound of a distended bursa reveals a fluid collection with either simple anechoic or more complex hypoechoic fluid. Bursal distention is characteristically unilocular and compressible, unlike other structures such as ganglion cysts, which are usually multilocular and non-compressible. This article reviews the anatomical locations of common bursae and shows pathological examples using ultrasound. Knowledge of typical locations and imaging appearances of bursae can aid in narrowing the differential diagnosis and guiding further management and treatment decisions.

  2. 2'-O-Methylation within Bacterial RNA Acts as Suppressor of TLR7/TLR8 Activation in Human Innate Immune Cells.

    Science.gov (United States)

    Rimbach, Katharina; Kaiser, Steffen; Helm, Mark; Dalpke, Alexander H; Eigenbrod, Tatjana

    2015-01-01

    Microbial RNA is an important stimulator of innate immune responses. Differences in posttranscriptional RNA modification profiles enable the immune system to discriminate between self and non-self nucleic acids. This principle may be exploited by certain bacteria to circumvent immune cell activation. In this regard, 2'-O-methylation of Escherichia coli tRNATyr at position 18 (Gm18) has recently been described to inhibit TLR7-mediated IFN-α production in human plasmacytoid dendritic cells (pDCs). Extending these findings, we now demonstrate that Gm18 also potently inhibits TLR7-independent human monocyte activation by RNA derived from a variety of bacterial strains. The half minimal inhibitory concentration values were similar to those found for IFN-α inhibition in pDCs. Mechanistically, 2'-O-methylated RNA impaired upstream signalling events, including MAP kinase and NFx03BA;B activation. Our results suggest that antagonizing effects of Gm18-modified RNA are due to competition with stimulatory RNA for receptor binding. The antagonistic effect was specific for RNA because the small molecule TLR7/8 agonist R848 was not inhibited. Despite the striking phenotype in human cells, 2'-O-methylated RNA did not interfere with TLR13 activation by bacterial 23S rRNA in murine DC and BMDM. Thus, we identify here Gm18 in E. coli tRNA(Tyr) as a universal suppressor of innate immune activation in the human but not the murine system. © 2015 S. Karger AG, Basel.

  3. TNF-α Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism

    Science.gov (United States)

    Lee, Jiyoung; Tian, Yongjun; Chan, Stephanie Tze; Kim, Ja Yeon; Cho, Cecilia; Ou, Jing-hsiung James

    2015-01-01

    Invasion by infectious pathogens can elicit a range of cytokine responses from host cells. These cytokines provide the initial host defense mechanism. In this report, we demonstrate that TNF-α, a pro-inflammatory cytokine, can be induced by hepatitis C virus (HCV) in its host cells in a biphasic manner. The initial induction of TNF-α by HCV was prompt and could be blocked by the antibody directed against the HCV E2 envelope protein and by chemicals that inhibit endocytosis, indicating the specificity of endocytic uptake of HCV in this induction. Further studies indicated that the induction of TNF-α was dependent on toll-like receptors 7 and 8 (TLR7/8) but not on other intracellular pattern recognition receptors. Consistently, siRNA-mediated gene silencing of the downstream effectors in the TLR7/8 signaling pathway including MyD88, IRAK1, TRAF6, TAK1 and p65 NF-κB suppressed the expression of TNF-α. The role of p65 NF-κB in the induction of TNF-α via transcriptional up-regulation was further confirmed by the chromatin immunoprecipitation assay. TNF-α induced by HCV could activate its own receptor TNFR1 on hepatocytes to suppress HCV replication. This suppressive effect of TNF-α on HCV was due to its role in supporting interferon signaling, as the suppression of its expression led to the loss of IFNAR2 and impaired interferon signaling and the induction of interferon-stimulated genes. In conclusion, our results indicate that hepatocytes can sense HCV infection via TLR7/8 to induce the expression of TNF-α, which inhibits HCV replication via an autocrine mechanism to support interferon signaling. PMID:26023919

  4. A West Nile virus NS4B-P38G mutant strain induces adaptive immunity via TLR7-MyD88-dependent and independent signaling pathways

    OpenAIRE

    Xie, Guorui; Welte, Thomas; Wang, Jia; Whiteman, Melissa C.; Wicker, Jason A.; Saxena, Vandana; Cong, Yingzi; Barrett, Alan D.T.; Wang, Tian

    2013-01-01

    Prior work shows that an attenuated West Nile virus (WNV), the nonstructural (NS)4B-P38G mutant infection in mice induced strong immune responses and protected host from subsequent lethal wild-type WNV infection. Here, we investigated NS4B-P38G mutant infection in myeloid differentiation factor 88-deficient (MyD88−/−) and Toll-like receptor 7-deficient (TLR7−/−) mice and found they had enhanced susceptibility compared to wild-type mice. Both groups had lower WNV-specific IgM response and redu...

  5. Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses.

    Science.gov (United States)

    Goff, Peter H; Hayashi, Tomoko; Martínez-Gil, Luis; Corr, Maripat; Crain, Brian; Yao, Shiyin; Cottam, Howard B; Chan, Michael; Ramos, Irene; Eggink, Dirk; Heshmati, Mitra; Krammer, Florian; Messer, Karen; Pu, Minya; Fernandez-Sesma, Ana; Palese, Peter; Carson, Dennis A

    2015-03-01

    Current vaccines against influenza virus infection rely on the induction of neutralizing antibodies targeting the globular head of the viral hemagglutinin (HA). Protection against seasonal antigenic drift or sporadic pandemic outbreaks requires further vaccine development to induce cross-protective humoral responses, potentially to the more conserved HA stalk region. Here, we present a novel viral vaccine adjuvant comprised of two synthetic ligands for Toll-like receptor 4 (TLR4) and TLR7. 1Z105 is a substituted pyrimido[5,4-b]indole specific for the TLR4-MD2 complex, and 1V270 is a phospholipid-conjugated TLR7 agonist. Separately, 1Z105 induces rapid Th2-associated IgG1 responses, and 1V270 potently generates Th1 cellular immunity. 1Z105 and 1V270 in combination with recombinant HA from the A/Puerto Rico/8/1934 strain (rPR/8 HA) effectively induces rapid and sustained humoral immunity that is protective against lethal challenge with a homologous virus. More importantly, immunization with the combined adjuvant and rPR/8 HA, a commercially available split vaccine, or chimeric rHA antigens significantly improves protection against both heterologous and heterosubtypic challenge viruses. Heterosubtypic protection is associated with broadly reactive antibodies to HA stalk epitopes. Histological examination and cytokine profiling reveal that intramuscular (i.m.) administration of 1Z105 and 1V270 is less reactogenic than a squalene-based adjuvant, AddaVax. In summary, the combination of 1Z105 and 1V270 with a recombinant HA induces rapid, long-lasting, and balanced Th1- and Th2-type immunity; demonstrates efficacy in a variety of murine influenza virus vaccine models assaying homologous, heterologous, and heterosubtypic challenge viruses; and has an excellent safety profile. Novel adjuvants are needed to enhance immunogenicity and increase the protective breadth of influenza virus vaccines to reduce the seasonal disease burden and ensure pandemic preparedness. We show

  6. Serological Detection of Infectious Bursa Disease Virus Antibodies ...

    African Journals Online (AJOL)

    The detection and distribution of infectious Bursa disease (IBD) virus antibody among local species of birds was investigated in 4,655 ... imply that the birds have the potentials of becoming carriers and serve as source of spread of the disease to other ..... In Nigeria we have some militating factors against the infectious bursa ...

  7. TLR9 agonist, but not TLR7/8, functions as an adjuvant to diminish FI-RSV vaccine-enhanced disease, while either agonist used as therapy during primary RSV infection increases disease severity.

    Science.gov (United States)

    Johnson, Teresa R; Rao, Srinivas; Seder, Robert A; Chen, Man; Graham, Barney S

    2009-05-18

    Agonists for TLR7, TLR8, and TLR9 have been shown to enhance vaccine immunogenicity. We evaluated the impact of TLR activation on RSV disease in a murine model by administering TLR7/8 and TLR9 agonists during FI-RSV immunization or RSV infection. CpG administered during immunization reduced disease following challenge as evidenced by decreased lung pathology, illness, and cytokines. In marked contrast, TLR7/8 agonist had little impact. To evaluate potential therapeutic use, TLR agonists were administered during primary infection. Although type 2 cytokine responses decreased and type 1 cytokines and MIP-1-alpha/beta increased, both TLR7/8 and TLR9 agonists increased clinical symptoms and pulmonary inflammation when administered during primary infection. Thus, TLR9-induced signaling during FI-RSV immunization reduced vaccine-enhanced disease whereas immunostimulatory properties of TLR agonists enhanced disease severity when used during RSV infection. Immunomodulation elicited by TLR9 agonist confirms the adjuvant potential of TLR agonists during RSV immunization. However, in contrast to work done with HIV-1 vaccines, the inability of TLR7/8 agonist to boost type 1 vaccine-induced RSV immunity demonstrates pathogen-TLR specificity. These data reveal that the timing of administration of immunomodulatory agents is critical. Furthermore, these data underscore that amplification of anti-viral immune responses may result in immunopathology rather than immune-mediated protection.

  8. Ultrasound-guided corticosteroid injections for treatment of greater trochanteric pain syndrome: greater trochanter bursa versus subgluteus medius bursa.

    Science.gov (United States)

    McEvoy, Jennifer R; Lee, Kenneth S; Blankenbaker, Donna G; del Rio, Alejandro Munoz; Keene, James S

    2013-08-01

    The purpose of this study was to evaluate the effectiveness of corticosteroid injections into the greater trochanteric bursa as opposed to the subgluteus medius bursa in patients with greater trochanteric pain syndrome. We retrospectively reviewed 183 injections (149 performed in women, 34 performed in men; age range 23-90 years; median, 53 years) performed for treatment of greater trochanteric pain syndrome. A 10-cm visual analog scale survey was used to assess pain level before the procedure and 14 days after the procedure. A 3-mL corticosteroid solution was injected into either the greater trochanteric bursa or the subgluteus medius bursa under direct ultrasound guidance. Procedure images were retrospectively reviewed to determine the site of injection. Diagnostic images obtained at the time of the procedure were also reviewed for findings of tendinopathy, bursitis, and enthesopathy. Statistical analysis of differences in pain reduction was performed, as was analysis for association between pain relief and demographic variables of age, sex, previous injections, and ultrasound findings. Sixty-five injections met the inclusion criteria; 56 performed in women and nine performed in men (age range, 30-82 years; median, 53 years). Forty-one injections were into the greater trochanteric bursa and 24 into the subgluteus medius bursa. There was a statistically significant difference in pain reduction between greater trochanteric bursa and subgluteus medius bursa injections with a median pain reduction of 3 as opposed to 0 (p bursa may be more effective than injections into the subgluteus medius bursa for treatment of greater trochanteric pain syndrome.

  9. Delivery of TLR7 agonist to monocytes and dendritic cells by DCIR targeted liposomes induces robust production of anti-cancer cytokines

    DEFF Research Database (Denmark)

    Klauber, Thomas Christopher Bogh; Laursen, Janne Marie; Zucker, Daniel

    2017-01-01

    as their immune activating potential in blood-derived monocytes, myeloid DCs (mDCs), and plasmacytoid DCs (pDCs). Monocytes and mDCs were targeted with high specificity over lymphocytes, and exhibited potent TLR7-specific secretion of the anti-cancer cytokines IL-12p70, IFN-α 2a, and IFN-γ. This delivery system...... targeted by the tumor escape mechanisms to develop immunosuppressive phenotypes. Providing activated monocytes and DCs to the tumor tissue is therefore an attractive way to break the tumor-derived immune suppression and reinstate cancer immune surveillance. To activate monocytes and DCs with high...... could be a way to improve cancer treatment either in the form of a vaccine with co-formulated antigen or as an immunotherapeutic vector to boost monocyte and DC activity in combination with other treatment protocols such as chemotherapy or radiotherapy. Cancer immunotherapy is a powerful new tool...

  10. Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease

    Science.gov (United States)

    Hasham, Muneer G.; Baxan, Nicoleta; Stuckey, Daniel J.; Branca, Jane; Perkins, Bryant; Dent, Oliver; Duffy, Ted; Hameed, Tolani S.; Stella, Sarah E.; Bellahcene, Mohammed; Schneider, Michael D.; Harding, Sian E.; Rosenthal, Nadia

    2017-01-01

    ABSTRACT Systemic autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) show significant heart involvement and cardiovascular morbidity, which can be due to systemically increased levels of inflammation or direct autoreactivity targeting cardiac tissue. Despite high clinical relevance, cardiac damage secondary to systemic autoimmunity lacks inducible rodent models. Here, we characterise immune-mediated cardiac tissue damage in a new model of SLE induced by topical application of the Toll-like receptor 7/8 (TLR7/8) agonist Resiquimod. We observe a cardiac phenotype reminiscent of autoimmune-mediated dilated cardiomyopathy, and identify auto-antibodies as major contributors to cardiac tissue damage. Resiquimod-induced heart disease is a highly relevant mouse model for mechanistic and therapeutic studies aiming to protect the heart during autoimmunity. PMID:28250051

  11. Innate immune receptors in human airway smooth muscle cells: activation by TLR1/2, TLR3, TLR4, TLR7 and NOD1 agonists.

    Directory of Open Access Journals (Sweden)

    Anne Månsson Kvarnhammar

    Full Text Available BACKGROUND: Pattern-recognition receptors (PRRs, including Toll-like receptors (TLRs, NOD-like receptors (NLRs and RIG-I-like receptors (RLRs, recognize microbial components and trigger a host defense response. Respiratory tract infections are common causes of asthma exacerbations, suggesting a role for PRRs in this process. The present study aimed to examine the expression and function of PRRs on human airway smooth muscle cells (HASMCs. METHODS: Expression of TLR, NLR and RLR mRNA and proteins was determined using real-time RT-PCR, flow cytometry and immunocytochemistry. The functional responses to ligand stimulation were investigated in terms of cytokine and chemokine release, cell surface marker expression, proliferation and proteins regulating the contractile state. RESULTS: HASMCs expressed functional TLR2, TLR3, TLR4, TLR7 and NOD1. Stimulation with the corresponding agonists Pam3CSK4, poly(I:C, LPS, R-837 and iE-DAP, respectively, induced IL-6, IL-8 and GM-CSF release and up-regulation of ICAM-1 and HLA-DR, while poly(I:C also affected the release of eotaxin and RANTES. The proliferative response was slightly increased by LPS. Stimulation, most prominently with poly(I:C, down-regulated myosin light chain kinase and cysteinyl leukotriene 1 receptor expression and up-regulated β2-adrenoceptor expression. No effects were seen for agonist to TLR2/6, TLR5, TLR8, TLR9, NOD2 or RIG-I/MDA-5. CONCLUSION: Activation of TLR2, TLR3, TLR4, TLR7 and NOD1 favors a synthetic phenotype, characterized by an increased ability to release inflammatory mediators, acquire immunomodulatory properties by recruiting and interacting with other cells, and reduce the contractile state. The PRRs might therefore be of therapeutic use in the management of asthma and infection-induced disease exacerbations.

  12. Clearing a blind spot in knee arthroscopy: popliteal bursa.

    Science.gov (United States)

    Ahn, Jin-Hwan; Lee, Dong-Hoon; Lee, Yong-Seuk; Wang, Joon-Ho; Ha, Hae-Chan

    2008-06-01

    Each arthroscopic portal to the knee has a blind area that cannot be inspected directly. In particular, visualization of the posterior compartment is difficult to access. Although arthroscopic procedures for the posterior compartment of the knee joint have been developed through posteromedial, posterolateral and posterior trans-septal portal, the popliteal bursa remains as an area that is difficult to access and manipulate. We report a surgical procedure that can examine one of the blind spots in knee arthroscopy, popliteal bursa.

  13. The Determinants of FTSE4 Good Bursa Malaysia

    OpenAIRE

    Abu Nor ‘Asyiqin; Baba Hajjah Hanim Norza; Basri Siti Aisyah; Mahat Zaleha

    2017-01-01

    This study was conducted to identify the factors that influence the companies listed in Bursa Malaysia to be indexed as FTSE4Good Bursa Malaysia (F4GBM). The companies awarded as F4GBM are those with good sustainable practices. This study investigates the potential factors that explain the good sustainable practice (i.e. corporate size, financial performance, industry attachment and sharia-compliant). Analysis reveals that only corporate size which proxy by market capitalization has significa...

  14. Web Document Analysis for Companies Listed in Bursa Malaysia

    OpenAIRE

    Juhana Salim; Lizawati Mi Yusuf; Mohd Shahizan Othman

    2009-01-01

    This paper discusses a research on web document analysis for companies listed on Bursa Malaysia which is the forerunner of financial and investment center in Malaysia. Data set used in this research are from the company web documents listed in the Main Board and Second Board on Bursa Malaysia. This research has used the Web Resources Extraction System which was developed by the research group mainly to extract information for the web documents involved. Our research findings have shown that t...

  15. Sonographically Guided Semimembranosus Bursa Injection: Technique and Validation.

    Science.gov (United States)

    Onishi, Kentaro; Sellon, Jacob L; Smith, Jay

    2016-01-01

    To describe and validate a sonographically guided (SG) semimembranosus (SM) bursa injection technique in an unembalmed cadaveric model. Prospective, cadaveric laboratory investigation. Academic institution procedural skills laboratory. Ten unembalmed cadaveric thigh-knee-ankle-foot specimens from 4 male and 6 female donors ages 55-92 years (mean 76.2 years) with body mass indices of 15.4-31.8 kg/m(2) (mean 21.9 kg/m(2)). A single, experienced operator completed SG SM bursa injections in 10 unembalmed cadaveric knees using 3 mL of diluted colored latex. At a minimum of 2 days after the injection, co-investigators dissected the specimens to assess the distribution of latex with respect to the SM bursa. Injections were graded for accuracy as follows: accurate (all latex contained within the SM bursa), accurate with overflow (latex within the SM bursa and extending into regions other than the needle track), or inaccurate (no latex within the SM bursa). All 10 injections (100%) accurately placed latex within the SM bursa and resulted in proximal spread to at least the level of the knee joint. Eight of 10 injections (80%) demonstrated minimal (<1 mL) extrabursal flow without extension into the intra-articular space. No neurovascular injury occurred in any specimen. SG SM injections are feasible and accurate and may be considered for diagnostic and therapeutic injections in patients with suspected distal SM disorders. Injection volumes less than 3 mL should be considered to reduce extrabursal spread as clinically indicated. Copyright © 2016 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.

  16. Clinical anatomy of the retrocalcaneal bursa.

    Science.gov (United States)

    Kachlik, D; Baca, V; Cepelik, M; Hajek, P; Mandys, V; Musil, V; Skala, P; Stingl, J

    2008-06-01

    The goal of the study was to perform a detailed anatomical description of the retrocalcaneal bursa (RB). Its morphological arrangement was studied on 10 fresh and 30 embalmed lower extremities by microdissection and light microscopy. The RB was present constantly and in all the cases contained 1-2 cm long synovial fold, beginning on the upper wall of RB and distally interposed between the anterior surface of the Achilles tendon and the posterior surface of the calcaneal tuberosity. The volume of RB was 1-1.5 ml. The histological analysis confirmed that the inner surface of the superior and posterior wall of RB have been covered by unilayered synovial membrane, projecting into synovial villi of different shapes and sizes. In the ceiling of RB, delicate fascicle of skeletal muscle fibers was discovered, radiating distally into the regularly present synovial fold. The whole bottom of RB has been covered by 200-500 microm layer of fibrous cartilage into which the calcaneal tendon attached. The cartilagineous layer continued anteroproximally to cover the whole bursal surface of the calcaneal tuberosity, where the thickness of the cortical bone was reduced on mere 50 microm. The obtained results can be used in the improvement of the differential diagnostics and therapy of diagnostics and therapy of the retrocalcaneal bursitis as well as of other kinds of achillar enthesopathies and heel pain.

  17. Sonography of the bicipitoradial bursa: A short pictorial essay.

    Science.gov (United States)

    Draghi, F; Gregoli, B; Sileo, C

    2012-02-01

    Serous bursae consist of a synovial membrane enveloping a film of liquid. They are located at interfaces between moving structures where friction must be reduced. The bicipitoradial bursa lies between the distal tendon of the biceps brachii, which it surrounds, and the radial tuberosity. It is a relatively large bursa, with dimensions ranging from 2.4 to 3.9 cm. It sometimes presents septation. It does not communicate with the joint cavity, but it may communicate with the interosseous bursa of the elbow. Regardless of its cause, bicipitoradial bursitis presents as a mass in the cubital fossa and/or with neurological symptoms (sensorial and/or motorial) caused by compression of the radial nerve. On ultrasonography, the inflamed bursa is visualized as an anechoic formation surrounding the distal biceps tendon. In addition to its role in diagnosing the bursitis, sonography can provide information about radial nerve injury (in the presence of macroscopic damage), and it can also be used for guidance during intrabursal injections.

  18. [Treatment concept for a traumatic lesion of the prepatellar bursa].

    Science.gov (United States)

    Kaiser, P; Schmidle, G; Raas, C; Blauth, M

    2015-10-01

    Rapid recovery of the skin and soft tissue of the affected knee joint with surgical debridement of the wound and gentle, as well as risk-balanced partial resection of the traumatic lacerated prepatellar bursa. Functional aftercare with directed administration of antibiotics only. Acute, traumatic laceration of the prepatellar bursa. Heavy contamination of the wound. Large, not closable skin defect or deep abrasion. Preexisting local infection. Additional fracture of the patella. Limited patient's cooperation, e. g., alcohol addiction or dementia. Subdermal application of local anesthesia through the exposed wound margins. Exploration of the wound and excision of the wound margins. Dissection of the boundary layer between the bursa and the subcutaneous fat. Debridement of the wound and excision of the bruised and contaminated bursa tissue. Repetitive rinsing. Insertion of loop drainage. Single-layer wound closure. Crepe bandage. Crepe bandage until the first wound inspection. Wound inspection on postoperative day 2 with removal of the loop. Pain-adapted functional treatment. Antithrombotic therapy until full weight-bearing. Removal of the stitches on postoperative day 14. Antibiotic prophylaxis (1st generation cephalosporin) for immunocompromised or polymorbid patients or heavily contaminated wounds. In 2013, we treated 50 traumatic lacerations of the prepatellar bursa. Four had to undergo further surgical treatment after primary care. In two other patients, one infected and one non-infected wound healing complication developed, which could be treated conservatively.

  19. High-resolution Sonographic Measurements of Lower Extremity Bursae in Chinese Healthy Young Men

    Directory of Open Access Journals (Sweden)

    Yong-Yan Gao

    2016-01-01

    Conclusions: Using HR-US imaging, we were able to analyze lower extremity bursae with high detection rates in healthy young men. The normal ranges of lower extremity bursa dimensions in healthy young men measured by HR-US in this study could be used as reference values for evaluation of bursa abnormalities in the lower extremity.

  20. Lipoma arborescens of the subdeltoid bursa: a case report.

    Science.gov (United States)

    Teusink, Matthew; El-Khoury, Georges; Buckwalter, Joseph

    2010-01-01

    Lipoma arborescens is a benign, diffuse villous proliferation of the synovium characterized by replacement of the subsynovial tissue by mature adipocytes. Its etiology is unknown and fewer than 100 cases have been reported. It resembles other collections of subsynovial fat, the only difference being its large size and villous macroscopic appearance. It typically presents in patients in their fifth through seventh decades of life. It is most commonly monoarticular and most frequently affects the suprapatellar pouch of the knee. There have been reports of involvement of the hip, shoulder, wrist, elbow, ankle, and associated bursae. To our knowledge there have been only three previous cases of lipoma arborescens of the subdeltoid bursa in the literature. We report on a case of unilateral lipoma arborescens of the subdeltoid bursa in an elderly patient presenting as a shoulder mass.

  1. Achilles enthesis ultrasound: the importance of the bursa in spondyloarthritis.

    Science.gov (United States)

    Falcao, Sandra; de Miguel, Eugenio; Castillo-Gallego, Concepción; Peiteado, Diana; Branco, Jaime; Martín Mola, Emilio

    2013-01-01

    This paper aims to assess the prevalence and relevance of the bursa-synovial lesion in spondyloarthritis (SpA). A transversal blind and controlled two-dimensional (2D) and three-dimensional (3D) ultrasound (US) study of Achilles enthesis bursa in early SpA was undertaken. Clinical outcome measures were collected. Bilateral Achilles enthesis of 66 early SpA patients (34 women) and 46 control patients (23 asymptomatic healthy subjects and 23 rheumatoid arthritis [RA] patients) were analysed. Mean BASDAI, BASFI and BASRI-spine were 4.55±2.08, 2.16±1.95 and 0.65±0.77, respectively. Mean erythrocyte sedimentation rate (ESR) was 10.93±12.35 mm/h and C-reactive protein (CRP) was 6.46±10.09 mg/l. The κ-values for intra-reader agreement for 2D and 3D images and bursa measurement were 0.82 and 0.98, respectively. Bursas were visualised in 89/132 SpA enthesis (67.4%) vs. 27/46 enthesis (58.7%) of healthy controls (pbursas were analysed, the SpA group had a mean of 1.52±1.47 mm versus 0.76±0.76 mm in the healthy control group (pbursa >2 was found. No Doppler signal was detected in controls, but 6.6% of SpA Achilles enthesis had Doppler bursitis. Heel pain was more frequent when bursa was present (pbursa and Doppler signal at retrocalcaneal bursa level could have a relevant contribution to differentiate SpA patients, and were correlated with clinical outcomes of SpA disease activity.

  2. Ultrasound-guided ischial bursa injection: technique and positioning considerations.

    Science.gov (United States)

    Wisniewski, Steve J; Hurdle, Mark; Erickson, Jason M; Finnoff, Jonathan T; Smith, Jay

    2014-01-01

    To 1) describe and validate an ultrasound-guided ischial bursa injection technique in an unembalmed cadaveric model and 2) to compare the distance between the ischial tuberosity and the sciatic nerve in a hip neutral versus 90° flexed hip position in asymptomatic volunteers. The first part was a single-blind prospective study. The second part was a prospective cohort study. An academic institution procedural skills laboratory and outpatient clinic. The first part of the study involved 1 cadaveric specimen. The second part of the study involved 20 asymptomatic subjects. The mean age of the subjects was 28 years, and the mean (standard deviation) body mass index was 23.2 ± 2.8 kg/m(2) (minimum, 18.3 kg/m(2); maximum, 29.5 kg/m(2)). In the first part of the study, a single operator completed bilateral ultrasound-guided ischial bursa injections in an unembalmed cadaveric specimen by using diluted colored latex. In the second part of the study, ultrasound was used in 20 asymptomatic volunteer subjects (10 men and 10 women) to measure the distance from the lateral edge of the ischial tuberosity to the sciatic nerve. The injections were graded for accuracy as follows: accurate (all injectate contained within the ischial bursa), accurate with overflow (injectate within the ischial bursa but also located in adjacent structures other than the needle track), or inaccurate (injectate not within the ischial bursa). The second part of the study measured the distance from the ischial tuberosity to the sciatic nerve with subjects in 2 different positions (prone and side lying with the tested hip flexed to 90°). Postinjection cadaveric dissections revealed that both ultrasound-guided injections accurately placed liquid latex within the ischial bursae. There was no evidence of injury to surrounding neurovascular structures. Among asymptomatic volunteers, the average distance between the ischial tuberosity and the sciatic nerve increased from 28.4 mm (range, 20.5-38.9 mm) in the

  3. The Determinants of FTSE4 Good Bursa Malaysia

    Directory of Open Access Journals (Sweden)

    Abu Nor ‘Asyiqin

    2017-01-01

    Full Text Available This study was conducted to identify the factors that influence the companies listed in Bursa Malaysia to be indexed as FTSE4Good Bursa Malaysia (F4GBM. The companies awarded as F4GBM are those with good sustainable practices. This study investigates the potential factors that explain the good sustainable practice (i.e. corporate size, financial performance, industry attachment and sharia-compliant. Analysis reveals that only corporate size which proxy by market capitalization has significant relationship with good sustainable practice.

  4. Evaluation of four techniques for injecting the trochanteric bursa of horses.

    Science.gov (United States)

    Tóth, Ferenc; Schumacher, Jim; Schramme, Michael; Hecht, Silke

    2011-06-01

    To describe the anatomic features of the equine trochanteric bursa and to evaluate 4 techniques for bursa centesis. Prospective, randomized design. Equine cadavers (n=2) and 20 live horses. The trochanteric bursae of 2 equine cadavers were injected with latex to identify the boundaries of the bursae. Four techniques for centesis of the trochanteric bursa were evaluated by attempting to inject dye into both trochanteric bursae of 20 live horses. Techniques included injection of the bursa with the limb-bearing weight and injection with the limb nonweight bearing and supported on a block, with or without ultrasonographic guidance of the needle. Ultrasonographic guidance of the needle was performed with or without the use of a guide channel attached to the ultrasound probe. Each of the 4 techniques was used to inject 10 bursae. The region of the bursa was dissected after horses were euthanatized to determine the location of the dye. The trochanteric bursa was most successfully injected with the limb positioned caudally with the foot on a block, even though topographic landmarks for centesis were more difficult to identify when the limb was in this position. The highest incidence of success was achieved when the needle was inserted using ultrasonographic guidance with the foot in a Hickman block. Positioning the limb caudally with the foot nonweight bearing and on a block facilitated centesis of the trochanteric bursa. © Copyright 2011 by The American College of Veterinary Surgeons.

  5. Serological Detection of Infectious Bursa Disease Virus Antibodies ...

    African Journals Online (AJOL)

    The detection and distribution of infectious Bursa disease (IBD) virus antibody among local species of birds was investigated in 4,655 sera sample using Agar Gel precipitation test (AGPT). The results showed that local chickens had the highest distribution with 446 (9.58%) followed by ducks 218 (4.68%), guinea fowl 131 ...

  6. MR Imaging Features of Obturator Internus Bursa of the Hip

    Science.gov (United States)

    Lee, Sun Wha; Kim, Jong Oh

    2008-01-01

    The authors report two cases with distension of the obturator internus bursa identified on MR images, and describe the location and characteristic features of obturator internus bursitis; the "boomerang"-shaped fluid distension between the obturator internus tendon and the posterior grooved surface of the ischium. PMID:18682677

  7. Postnatal Development Of Bursa Of Fabricius in the Nigerian Local ...

    African Journals Online (AJOL)

    Postnatal development of the Bursa of Fabricius was studied in Nigerian local and Isa brown chickens. The local chickens attained maximum weight (.94g) at week 7 and week 13 for cockerels and pullet respectively while the Isa brown attained maximum weight (a.02g and 3.12g) at week 1 and 17 for cockerels and pullets ...

  8. MR Imaging Features of Obturator Internus Bursa of the Hip

    OpenAIRE

    Hwang, Ji Young; Lee, Sun Wha; Kim, Jong Oh

    2008-01-01

    The authors report two cases with distension of the obturator internus bursa identified on MR images, and describe the location and characteristic features of obturator internus bursitis; the "boomerang"-shaped fluid distension between the obturator internus tendon and the posterior grooved surface of the ischium.

  9. MR Imaging Features of Obturator Internus Bursa of the Hip

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Ji Young; Lee, Sun Wha; Kim, Jong Oh [School of Medicine, Ewha Womans University, Seoul (Korea, Republic of)

    2008-08-15

    The authors report two cases with distension of the obturator internus bursa identified on MR images, and describe the location and characteristic features of obturator internus bursitis; the 'boomerang'-shaped fluid distension between the obturator internus tendon and the posterior grooved surface of the ischium

  10. MR imaging features of obturator internus bursa of the hip.

    Science.gov (United States)

    Hwang, Ji Young; Lee, Sun Wha; Kim, Jong Oh

    2008-01-01

    The authors report two cases with distension of the obturator internus bursa identified on MR images, and describe the location and characteristic features of obturator internus bursitis; the "boomerang"-shaped fluid distension between the obturator internus tendon and the posterior grooved surface of the ischium.

  11. Determination of native woody landscape plants in Bursa and Uludag

    African Journals Online (AJOL)

    PRECIOUS

    2009-11-02

    Nov 2, 2009 ... shrubs, 7 treelets and 4 climber groups, around the region which are notified to be suitable for rural and urban planning with the intentions of solitary, group, alley, wind-break, ground cover and attractive flowering and fruit. Key words: Woody plants, landscape planning, Bursa-Uludag. INTRODUCTION.

  12. Determination of native woody landscape plants in Bursa and Uludag

    African Journals Online (AJOL)

    Around Bursa and Uludag is a wide range of native woody plants of which are commonly used for landscape planning. The present study pointed out a total of 72 plant species, consisting of 36 trees, 32 shrubs, 7 treelets and 4 climber groups, around the region which are notified to be suitable for rural and urban planning ...

  13. An Unusual Prepatellar Bursa Swelling: Patellar Button Dissociation and Migration.

    Science.gov (United States)

    Hester, Thomas; Moftah, Farid

    2016-01-01

    Implant loosening is not a new phenomenon, nor is implant migration; however they are rarely seen after knee arthroplasty surgery. Complications with patellar buttons have been reported before with peg failure, loosening, and patella fracture; however extra-articular migration is extremely rare. We report an unusual case of patellar button migration 11 years after total knee arthroplasty to the prepatellar bursa.

  14. Ultrasound of the Gruberi Bursa With Cadaveric and MRI Correlation.

    Science.gov (United States)

    Gaetke-Udager, Kara; Jacobson, Jon A; Bhatti, Zeeshaan S; Smith, Jay; Parameswaran, Aishwarya; Fessell, David P

    2016-08-01

    The purpose of this study was to describe the appearance and ultrasound characteristics of the Gruberi bursa using a cadaveric model and retrospective ultrasound imaging review. For the cadaveric study, ultrasound of the dorsolateral ankle of a foot-ankle specimen was performed and was followed by injection of latex between the extensor digitorum longus (EDL) tendons and the talus and dissection. For the ultrasound imaging review, the radiology database was searched for ultrasound studies performed from September 15, 2000, through April 1, 2015, to identify subjects with a dorsolateral foot or ankle fluid collection detected on ultrasound. Images were retrospectively reviewed to characterize the location and size of the fluid collection, assess for the number of locules, and evaluate the compressibility of the fluid collection. It was determined whether the ultrasound findings were significantly different from chance: CI and p values were obtained from performing a test for one proportion. Dissection of a cadaveric specimen revealed latex within a well-defined region between the EDL tendons and the dorsolateral talus; this location is consistent with a Gruberi bursa. For the image review, the imaging examinations of 162 subjects (age range, 16-88 years; 31 male subjects and 131 female subjects) were reviewed. On the ultrasound images, a fluid collection with its epicenter between the dorsolateral talus and EDL was found in 93% of ankles. Of the fluid collections identified on ultrasound, 98% were unilocular and 94% were anechoic. Of these fluid collections, 133 were assessed for compressibility, and 89% were compressible. The positive findings for a Gruberi bursa that were different from chance (p bursa characteristically is located between the EDL and the talus; on ultrasound, the Gruberi bursa is most commonly unilocular, anechoic, and compressible.

  15. Clinical anatomy of the subacromial and related shoulder bursae: A review of the literature.

    Science.gov (United States)

    Kennedy, Marion S; Nicholson, Helen D; Woodley, Stephanie J

    2017-03-01

    The subacromial bursa (SAB) is the main bursa of the shoulder. It facilitates normal movement and is also commonly involved in shoulder disorders. Other shoulder bursae have been described but their anatomy has not been well studied. Anatomical variation of shoulder bursae has been suggested and this has implications for clinical practice. This article reviews current knowledge of the normal anatomy of the SAB and related shoulder bursae. A systematic review of the English and German literature was conducted using databases and a hand search of reference lists focusing on the clinical anatomy of the SAB, coracobrachial and subcoracoid bursae and subtendinous bursa of subscapularis. Twenty-four original sources and 13 textbooks were identified. Fifteen studies described the general morphology of the shoulder bursae using cadaveric specimens, eight examined innervation, and one provided information about the blood supply of the SAB. The literature agrees that the SAB is consistent and well innervated with a lateral subdeltoid part and a variable subcoracoid portion. There is variability regarding the consistency, location, and communications of the coracobrachial and subcoracoid bursae and the superior part of the subtendinous bursa of subscapularis, and little information on their nerve and blood supply. Several bursae are present around the shoulder joint. Further research is warranted to understand the precise attachments, dimensions, and communications of the bursae, as well as their nerve and blood supply. This information will improve understanding of the clinical relevance of these bursae and inform appropriate assessment and treatment. Clin. Anat. 30:213-226, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  16. The prepatellar bursa: cadaveric investigation of regional anatomy with MRI after sonographically guided bursography.

    Science.gov (United States)

    Aguiar, Rodrigo O; Viegas, Flavio C; Fernandez, Rodrigo Y; Trudell, Debra; Haghighi, Parviz; Resnick, Donald

    2007-04-01

    The purpose of this study was to use MRI and anatomic correlation in cadavers to show the macroscopic anatomic configuration of the prepatellar bursa. MRI of the prepatellar bursa of nine cadaveric knees was performed after sonographically guided bursography. The images were compared with those seen on anatomic sectioning. Histologic analysis was obtained in two specimens. Mean dimensions of the prepatellar bursa in the craniocaudal, lateromedial, and anteroposterior planes were 39.7, 40.5, and 3.2 mm, respectively. A trilaminar aspect of the bursa was shown in seven of the nine knees (78%) and a bilaminar appearance in two of the nine knees (22%). Lateral extension of the bursa over the patella was observed in three knees (33%) and medial extension in one knee (11%). On histopathologic analysis, three potential bursal spaces were found. The prepatellar bursa is most commonly a trilaminar structure, and variation in its relation to the patella can occur.

  17. Endoscopic Resection of the Lateral Ankle Bursa With Synovial Chondromatosis.

    Science.gov (United States)

    Lui, Tun Hing

    2016-06-01

    Bursal chondromatosis is synovial chondromatosis of the bursae. It is a rare disease entity that can involve the adventitial bursa of the lateral ankle. Complete synovectomy, removal of loose bodies, and bursectomy comprise the treatment of choice. Detailed preoperative radiologic assessment and surgical planning are the keys to success. Any accompanying synovial chondromatosis of the ankle or subtalar joint or tenosynovial chondromatosis of the peroneal tendon sheath should be treated together with the bursectomy. Endoscopic bursectomy can be performed through the bursal portal. The proximal and distal peroneal tendoscopy portals serve as viewing portals. The resection of the diseased tissues should be performed in a step-by-step zonal manner. Complete synovectomy and removal of loose bodies should be performed before bursectomy. Internal drainage of the bursal sac into the peroneal tendon sheath may be indicated if the sac is adherent to the skin. It should only be performed after complete synovectomy and removal of loose bodies.

  18. Bursa formation with scapular osteochondroma in hereditary multiple exostosis.

    Science.gov (United States)

    Ceberut, Kadri; Korkmaz, Murat; Ergin, Ismail; Müslehiddinoglu, Ahmet

    2013-07-01

    Osteochondroma is the most common benign bone tumour present multiple hereditary exostosis (HME). Scapular osteochondroma associated with pain and bursitis is rarely reported in literature. Here, we describe a 49-year-old male with the diagnosis of HME who was admitted to the Department of Thoracic Surgery with a painful and rapidly enlarging mass behind the left scapula. Computed tomography and magnetic resonance imaging indicated a large bursa formation associated with chest wall mass. Pre-operatively, the mass was diagnosed as osteochondroma and resected. Pathological findings confirmed that mass was a large bursa formation due to scapular osteochondroma without any evidence of malignancy. Osteochondroma should be considered in differential diagnosis of chest wall tumours located at this specific site. We discuss this rare complication of HME and emphasize the importance of early diagnosis and differentiation from malignant transformation of osteochondroma.

  19. Multiresolution analysis of Bursa Malaysia KLCI time series

    Science.gov (United States)

    Ismail, Mohd Tahir; Dghais, Amel Abdoullah Ahmed

    2017-05-01

    In general, a time series is simply a sequence of numbers collected at regular intervals over a period. Financial time series data processing is concerned with the theory and practice of processing asset price over time, such as currency, commodity data, and stock market data. The primary aim of this study is to understand the fundamental characteristics of selected financial time series by using the time as well as the frequency domain analysis. After that prediction can be executed for the desired system for in sample forecasting. In this study, multiresolution analysis which the assist of discrete wavelet transforms (DWT) and maximal overlap discrete wavelet transform (MODWT) will be used to pinpoint special characteristics of Bursa Malaysia KLCI (Kuala Lumpur Composite Index) daily closing prices and return values. In addition, further case study discussions include the modeling of Bursa Malaysia KLCI using linear ARIMA with wavelets to address how multiresolution approach improves fitting and forecasting results.

  20. Rapid Destruction of the Hip Joint Accompanied by an Enlarged Iliopsoas Bursa in a Healthy Man

    Science.gov (United States)

    Kim, Ju-Oh

    2014-01-01

    Association between enlarged iliopsoas bursa and hip lesions such as osteoarthritis of the hip or femoral head necrosis is infrequently seen. Enlarged iliopsoas bursa with a rapidly destructive arthropathy is claimed to be seen only in patients with rheumatoid arthritis. In this paper, we report a patient with a rapidly destructive arthropathy accompanied by an enlarged iliopsoas bursa that has been misdiagnosed as an infection. PMID:27536579

  1. Synovial osteochondromatosis in the subacromial bursa mimicking calcific tendinitis: sonographic diagnosis.

    Science.gov (United States)

    Kim, Tae-Kwon; Lee, Dae-Hee; Park, Jong-Hoon; Kim, Chul-Hwan; Jeong, Woong-Kyo

    2014-05-01

    Synovial osteochondromatosis is an idiopathic benign metaplasia of the synovial membrane rarely found in an extra-articular bursa. We describe the case of a 55-year-old woman with synovial osteochondromatosis in the subacromial bursa mimicking calcific tendinitis. Plain radiographs showed a radiopaque mass over the middle facet of the greater tuberosity, suggesting calcific tendinitis. Sonography, however, showed a loose body in the subacromial bursa, and no evidence of calcification inside the rotator cuff. Copyright © 2013 Wiley Periodicals, Inc.

  2. High-resolution Sonographic Measurements of Lower Extremity Bursae in Chinese Healthy Young Men

    Science.gov (United States)

    Gao, Yong-Yan; Wu, Chi-Qiu; Liu, Wei-Xing; Zhang, Lei; Li, Chun-Ling

    2016-01-01

    Background: Lower extremity bursae are very vulnerable to injury during strenuous physical exercises. Understanding the imaging characteristics of normal bursae is essential for early diagnosis of morphological abnormalities. Therefore, we evaluated the normal range of lower extremity bursae in healthy young men using high-resolution ultrasound (HR-US) imaging. Methods: Bursae in the lower extremities were examined by HR-US in 290 Chinese healthy young men with a median age of 18 years (range, 18–23 years). The bilateral suprapatellar bursa (SPB), deep infrapatellar bursa (DIPB), popliteal bursa (PB), and retrocalcaneal bursa (RCB) were imaged and measured for analysis. Results: The HR-US identification rates of the SPB, DIPB, PB, and RCB were 89.0% (517/580), 55.0% (319/580), 29.4% (171/580), and 49.5% (287/580), respectively. With the assumption that the bursae were normal in 95% of the study participants, the length and width values at the maximal cross-section of the SPB, DIPB, PB, and RCB were ≤18.00 and 6.09 mm, 8.10 and 2.11 mm, 7.67 and 3.93 mm, and 7.82 and 2.04 mm, respectively. Conclusions: Using HR-US imaging, we were able to analyze lower extremity bursae with high detection rates in healthy young men. The normal ranges of lower extremity bursa dimensions in healthy young men measured by HR-US in this study could be used as reference values for evaluation of bursa abnormalities in the lower extremity. PMID:26831233

  3. An Unusual Prepatellar Bursa Swelling: Patellar Button Dissociation and Migration

    Directory of Open Access Journals (Sweden)

    Thomas Hester

    2016-01-01

    Full Text Available Implant loosening is not a new phenomenon, nor is implant migration; however they are rarely seen after knee arthroplasty surgery. Complications with patellar buttons have been reported before with peg failure, loosening, and patella fracture; however extra-articular migration is extremely rare. We report an unusual case of patellar button migration 11 years after total knee arthroplasty to the prepatellar bursa.

  4. Comparison of two techniques for injection of the podotrochlear bursa in horses.

    Science.gov (United States)

    Piccot-Crézollet, Cyrille; Cauvin, Eddy R; Lepage, Olivier M

    2005-05-01

    To compare accuracy of 2 methods for injection of the podotrochlear bursa in horses. Observational study. 17 French Standardbreds. In each horse, contrast medium was injected into the podotrochlear bursa of 1 foot by use of a distal palmar approach with the needle inserted parallel to the sole (DPPS) and into the podotrochlear bursa of the other foot by use of a distal palmar approach to the navicular position (DPNP). Podotrochlear bursa injection was evaluated by means of radiographic examination in all horses and postmortem examination in 6. Contrast medium was successfully injected into the podotrochlear bursa in 6 of 16 feet in which the DPPS method was used and 14 of 17 feet in which the DPNP method was used; these results were significantly different. Failure was attributed to contrast medium invading the distal interphalangeal joint, contrast medium pooling palmar to the deep digital flexor tendon, contrast medium located in the podotrochlear bursa and the distal interphalangeal joint, contrast medium located in the podotrochlear bursa and the area palmar to the deep digital flexor tendon, and an inability to inject contrast medium despite adequate needle placement. Results suggest that the DPNP technique can be used successfully for injection into the podotrochlear bursa in horses. However, radiographic assessment should be used to confirm that material was injected into the bursa.

  5. Protection against apoptosis in chicken bursa and thymus cells by phorbol ester in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Asakawa, J.; Thorbecke, G.J. (Univ. of New York, New York (United States))

    1991-03-15

    Programmed suicide or apoptosis, due to activation of endogenous nucleases, occurs in immature CD4{sup {minus}}85{sup {minus}} mammalian thymus cells. Like the thymus, the bursa of Fabricius is a site of massive lymphopoiesis accompanied by cell death in vivo. In the present study the authors have, therefore, examined whether chicken bursa and thymus cells exhibit apoptosis. Bursa and thymus cells from SC chickens, 4-10 weeks of age, were incubated for 8-24 hrs with various reagents. Genomic DNA was isolated, electrophoresed in 3% Nusieve agarose gels, and examined for patterns of DNA fragmentation. A laddering of DNA in multiples of 200 base pairs, indicative of apoptosis, was observed with both bursa and thymus cells. These patterns of DNA fragmentation from bursa cells could be prevented by adding phorbol myristic acetate during culture and, more effectively, by PMA plus ionomycin, but not by ionomycin alone or by anti-{mu}. PMA did not affect the patterns of DNA fragmentation seen with spleen cells. Addition of the protein kinase C inhibitor staurosporin inhibited the preventive effect of PMA on apoptosis. PMA also greatly promoted the survival of bursa cells in culture, as assayed by percentage cell death and by {sup 3}H-thymidine incorporation. It is concluded that bursa and thymus cells from the chicken exhibit apoptosis. The data further suggest that protein kinase C activation protects apoptosis in cultured bursa cells.

  6. Expression of the ephrin receptor B2 in the embryonic chicken bursa of Fabricius

    Science.gov (United States)

    Chicken B-cells develop in a specific organ, the bursa of Fabricius. To understand the bursal microenvironment guiding B-cell development, previous studies identified ephrin (Eph) receptor B2 (EphB2) gene transcripts in the embryonic bursa. We hypothesize that the EphB2 receptors and their ligands r...

  7. ROLE OF ENVIRONMENTAL ANTIGEN IN THE DEVELOPMENT OF IGG(+) CELLS IN THE BURSA OF FABRICIUS

    NARCIS (Netherlands)

    EKINO, S; RIWAR, B; KROESE, FGM; SCHWANDER, EH; NIEUWENHUIS, P

    1995-01-01

    IgG(+) cells were detected in the bursa of Fabricius after hatching by immunofluorescence staining of single cells and immunohistologic studies using mAb anti-Ig gamma-heavy chain. The frequency of IgG(+) cells in the bursa increased rapidly immediately after hatching. In histologic studies, most of

  8. The deep infrapatellar bursa: prevalence and morphology on routine magnetic resonance imaging of the knee.

    Science.gov (United States)

    Aydingoz, Ustun; Oguz, Berna; Aydingoz, Onder; Comert, Ruhi Baris; Akgun, Isik

    2004-01-01

    To evaluate the presence, location, and dimensions of the deep infrapatellar bursa on routine magnetic resonance (MR) imaging of the knee. The study group consisted of 213 knees in 204 consecutive individuals who had undergone routine MR imaging examination of the knee within a 365-day period. Magnetic resonance examinations consisted of T1-, proton-density-, and T2-weighted sagittal; spectral presaturation inversion recovery coronal; and T2*-weighted transverse sequences. Exclusion criteria were previous knee arthroscopy or surgery or the presence of a mass lesion infiltrating the infrapatellar fat pad. The presence, location, and dimensions of the deep infrapatellar bursa were studied. The bursa was also analyzed with regard to knee joint synovial effusion (absent, mild, or marked). The deep infrapatellar bursa was detected in 68% of the knees, most commonly on the lateral paramedian sagittal MR images. There was no statistically significant difference between male and female subjects or between the knee sides with regard to the detection of the deep infrapatellar bursa (P > 0.05). No correlation was found between synovial effusion and the presence of the deep infrapatellar bursa. The mean anteroposterior and craniocaudal dimensions of the deep infrapatellar bursa on sagittal T2-weighted MR images were 2.1-2.7 mm and 7.3-9.1 mm, respectively, on its lateral, central, or medial location within the sagittal MR image stack. An awareness of the dimensions and location of the deep infrapatellar bursa is important in distinguishing it from pathologic lesions (eg, bursitis).

  9. Ossification of the infraspinatus tendon-bursa in 13 dogs.

    Science.gov (United States)

    McKee, W M; Macias, C; May, C; Scurrell, E J

    Ossification of the infraspinatus tendon-bursa was diagnosed in 13 labrador retrievers, 12 of which were lame in one thoracic limb and the other in both. They ranged in age from 28 to 121 months (mean 69.4 months). The lameness developed gradually and was progressive in 11 of the 14 affected joints. Scapular muscle atrophy and signs of pain on direct pressure over the infraspinatus tendon of insertion were key clinical signs. Caudocranial radiographs revealed multiple mineralised masses lateral to the proximal humerus or glenohumeral joint in 11 of the 26 joints and single masses in 12. An arthroscopic examination revealed concomitant ligament or tendon abnormalities in six of seven shoulders. The dogs were followed up from one to 55 months (mean 20 months). Of five shoulders treated with non-steroidal anti-inflammatory drugs (nsaids), one resolved, two improved and two were managed surgically. Of six shoulders treated by the injection of long-acting intra-articular corticosteroid (five before and one after surgery), three resolved, two improved and one was unchanged. Of six shoulders treated by the surgical resection of the infraspinatus tendon and bursa (three before and two after treatment with nsaids, and one after treatment with a long-acting intra-articular corticosteroid), four improved, one was unchanged and one was managed with an intra-articular long-acting corticosteroid. One shoulder was managed by restricted exercise and the lameness resolved. Histological examination of the excised tissues revealed heterotopic bone within the infraspinatus tendon and/or bursa.

  10. Minimal spanning tree for 100 companies in Bursa Malaysia

    Science.gov (United States)

    Bahaludin, Hafizah; Abdullah, Mimi Hafizah; Salleh, Supian Mat

    2015-02-01

    This paper investigates the stock market network among the stocks traded in Bursa Malaysia by using minimal spanning tree (MST) techniques. The daily closing prices from 2011 until 2013 of 100 companies based on market capitalization are chosen to construct the network. By constructing the stock market network, the most influential stocks in Malaysian stock market are identified by employing the centrality measurements which are degree, betweenness and closeness. The findings of this study ascertain that from the 100 companies studied, four companies are identified as the most influential in the Malaysian stock market.

  11. Case report: Lower extremity sparganosis in a bursa.

    Science.gov (United States)

    Ha, Kee-Yong; Oh, In-Soo

    2011-07-01

    Sparganosis is a rare parasitic infection caused by the plerocercoid tapeworm larva of the genus Spirometra. We report the case of a 67-year-old man with a mass over the anteromedial surface of the proximal extremity of the tibia. We surgically excised a bursa containing Spirometra larvae. Sparganosis is a rare parasitic infection. We found no cases of lower extremity sparganosis combined with bursitis reported in the literature. Sparganosis should be considered in the differential diagnosis of soft tissue tumors, especially among patients who frequently have consumed mountain water or raw snakes or frogs.

  12. Evaluation of the diffusion of corticosteroids between the distal interphalangeal joint and navicular bursa in horses.

    Science.gov (United States)

    Pauwels, Frederik E; Schumacher, James; Castro, Fernando A; Holder, Troy E; Carroll, Roger C; Sega, Gary A; Rogers, Chris W

    2008-05-01

    To determine whether clinically effective concentrations of methylprednisolone or triamcinolone can be achieved in the navicular bursa after injection of methylprednisolone acetate (MPA) or triamcinolone acetonide (TA) into the distal interphalangeal joint (DIPJ) and whether clinically effective concentrations of these drugs can be achieved in the DIPJ after injecting the navicular bursa with the same doses of MPA or TA. 32 healthy horses. Horses in groups 1 through 4 received 40 mg of MPA in the DIPJ, 10 mg of TA in the DIPJ, 40 mg of MPA in the navicular bursa, and 10 mg of TA in the navicular bursa, respectively. Concentrations of corticosteroids that diffused into the adjacent synovial structure were determined. For group 1, injection of MPA into the DIPJ yielded a mean +/- SD concentration of 0.24 +/- 0.072 microg of methylprednisolone/mL in the navicular bursa. For group 2, injection of TA into the DIPJ yielded 0.124 +/- 0.075 microg of triamcinolone/mL in the navicular bursa. For group 3, injection of MPA into the navicular bursa yielded 0.05 +/- 0.012 microg of methylprednisolone/mL in the DIPJ. For group 4, injection of TA into the navicular bursa yielded 0.091 +/- 0.026 microg of triamcinolone/mL in the DIPJ. A clinically effective concentration of methylprednisolone or triamcinolone diffused between the DIPJ and navicular bursa after intra-articular or intrabursal injection, which would justify injection of the DIPJ with MPA or TA to ameliorate inflammation of the navicular bursa.

  13. Synovial chondromatosis of pes anserine bursa secondary to osteochondroma.

    Science.gov (United States)

    Shallop, Brandon; Abraham, John A

    2014-08-01

    Osteochondromas are common benign bone tumors. Synovial chondromatosis is a benign cartilaginous metaplasia that occurs in the synovium. The authors describe a unique case of synovial chondromatosis developing in the pes anserine bursa secondary to an underlying osteochondroma of the proximal medial tibia. It is unusual to see both of these processes occurring simultaneously in 1 location. After appropriate consent was obtained, the patient's case was reviewed. A 17-year-old boy presented with a painless mass in the medial aspect of the right leg. Initial imaging of the right leg showed a cartilaginous-appearing lesion arising from the tibia and several distinct additional cartilaginous masses in the adjacent soft tissue. After 16 months of observation, the patient began to have increasing pain in the region of the lesion. The patient underwent surgery for excision of suspected synovial chondromatosis of the right pes anserine bursa and osteochondroma of the proximal right tibia. Postoperatively, the patient had complete resolution of symptoms and regained full range of motion of the knee. He returned to full activities, including walking and running. Osteochondromas are common benign bone tumors. Synovial chondromatosis is a benign synovial metaplastic cartilaginous proliferation that occurs primarily in joints, but can occur in any synovial-lined space. In this case report, the authors describe a unique occurrence of both of these lesions simultaneously. The treatment was excision of the osteochondroma and resection of the chondromatosis lesions, which resulted in an excellent outcome. Copyright 2014, SLACK Incorporated.

  14. Detection of subacromial bursa thickening by sonography in shoulder impingement syndrome.

    Science.gov (United States)

    Tsai, Yao-Hung; Huang, Tsung-Jen; Hsu, Wei-Hsiu; Huang, Kuo-Chin; Li, Yen-Yao; Peng, Kuo-Ti; Hsu, Robert Wen-Wei

    2007-01-01

    Normally, the subacromial-subdeltoid bursa is thinner than 2 mm using ultrasound examination. The subtle thickening of the bursa could be an early sign of subacromial impingement and possibly a rotator cuff tear. The aim of this study was to compare the thickness of subacromial bursa measured using ultrasonography in the painful shoulder with normal side, and also to differentiate Neer stages I and II impingements in patients with unilateral shoulder pain. We performed bilateral shoulder sonography in 268 consecutive patients with unilateral shoulder pain and clinical suggestion of rotator cuff pathology. The study group consisted of 102 cases of Neer stage I and 166 cases of Neer stage II impingement syndrome. The bursa thickness was calculated from the superficial peribursal fat to the upper margin of the supraspinatus. A statistically significant association was detected (p bursa in patients with Neer stage I impingement had no statistically important link the results of the patients with Neer stage II impingement. Increased bursa thickness in the symptomatic side may be an alternative sonographic indicator of subacromial bursitis and partial-thickness rotator cuff tears, even when measured to be less than 2 mm. Sonographic examination of subacromial bursa thickness is not an appropriate technique to differentiate the Neer stages I and II impingement. Further study is needed to quantify the echogenicity of the supraspinatus tendon and to show a level of accuracy in patients with rotator cuff tendinosis or partial tears.

  15. Positive contrast magnetic resonance bursography for assessment of the navicular bursa and surrounding soft tissues.

    Science.gov (United States)

    Maher, Michael C; Werpy, Natasha M; Goodrich, Laurie R; McIlwraith, C Wayne

    2011-01-01

    Magnetic resonance (MR) imaging is often performed to determine the cause of palmar heel pain. We evaluated how distension of the navicular bursa affected the MR appearance of the navicular bursa and associated structures. An MR evaluation was performed on normal cadaver limbs and cadaver limbs from horses with lameness localized to the foot. The normal navicular bursae were injected with 2, 4, or 6 ml of solution. The bursae of the feet from lame horses were injected with 4 or 6 ml, and the MR study was repeated. All bursae were examined grossly to verify the presence or absence of adhesions. Clinical patients that had initial MRI abnormalities suggesting adhesions were also evaluated. Distension of the proximal recess of the normal navicular bursa, proximal to the collateral sesamoidean ligament was achieved with 2 ml. Separation of the collateral sesamoidian ligament from the deep digital flexor tendon (DDFT) was achieved with 4 ml. The separation of the navicular bone from the DDFT and distal sesamoidian impar ligament required 6 ml. Adhesions were more clearly defined in the bursa of the two pathologic cadaver limbs following distension. MR bursography used on clinical patients allowed the determination of the presence or absence of adhesions. In these horses, this determination could not have been definitively made without this technique. MR bursography is useful in horses where the presence of adhesions cannot be clearly defined by MRI. © 2011 Veterinary Radiology & Ultrasound.

  16. Human fetal anatomy of the posterior semimembranosus complex at the knee with special reference to the gastrocnemio-semimembranosus bursa.

    Science.gov (United States)

    Nakamura, Takuo; Suzuki, Daisuke; Murakami, Gen; Cho, Baik Hwan; Fujimiya, Mineko; Kozuka, Naoki

    2011-08-01

    There is little information on the fetal anatomy of the posterior semimembranosus tendinous complex and its associated bursa. We examined histological sections (transverse or sagittal) of the right or left knee in 13 mid-term human fetuses (12-25 weeks of gestation). The medial head of the gastrocnemius provided an aponeurosis facing or attached to the muscles of the pes anserinus by 12 weeks of gestation. The peritendinous tissue of the semimembranosus provided a bursa continuous with a laterally extending plate-like tissue by 15 weeks, but sometimes the typical bursa was absent. The aponeurosis of the medial head consistently accompanied a bursa-like space (false bursa) surrounded by heterogenous structures including the popliteus and a wall of the semimembranosus bursa. Sagittal sections displayed notches on the medial head surface that received the semimembranosus and semitendinosus overriding the medial head of the gastrocnemius. In contrast to a real bursa originating from the peritendinous tissue of the semimembranosus, a false bursa without a homogeneous wall consistently develops at the origin of the medial head of the gastrocnemius. Due to mechanical stress from the tendons, the false bursa is likely to develop into a structure similar to a real bursa with a synovial lining even if the real bursa is absent in the fetus. We hypothesize that the adult gastrocnemio-semimembranosus bursa, largely or partly, originates from the fetal false bursa. Absolute resection of the false bursa is difficult because it is a mere gap between normal tissues. Copyright © 2010 Elsevier B.V. All rights reserved.

  17. Accuracy of ultrasound-guided versus unguided pes anserinus bursa injections.

    Science.gov (United States)

    Finnoff, Jonathan T; Nutz, David J; Henning, Philip T; Hollman, John H; Smith, Jay

    2010-08-01

    To compare the accuracy of ultrasound (US)-guided versus unguided pes anserinus bursa injections in a cadaveric model. Single blind, prospective study. Academic institution procedural skills laboratory. Twenty-four unembalmed, unpaired adult cadaveric lower extremity specimens. A single investigator performed 12 US-guided and 12 unguided pes anserinus bursa injections using colored liquid latex into 24 unembalmed adult cadaveric lower extremity specimens. The order of the injection techniques was randomized. The specimens were subsequently dissected by a co-investigator blinded to the injection technique used for each injection. The injections were graded for accuracy as follows: accurate (all injectate contained within the pes anserinus bursa), accurate with overflow (injectate within the pes anserinus bursa, but also located in adjacent structures), or inaccurate (injectate not within the pes anserinus bursa). The accuracy of the 2 approaches was compared using Pearson chi(2) test with Williams' correction for the small sample size (P = .05). The accuracy rate was 92% (11 of 12 specimens) in the US-guided condition and 17% (2 of 12 specimens) in the unguided condition. One US-guided injection was considered accurate with overflow, whereas 4 unguided injections were accurate with overflow. The US-guided injection technique was significantly more accurate than the unguided technique (Williams-corrected chi(2) = 12.528, P bursa injections rarely place the injectate within the pes anserinus bursa, whereas US-guided pes anserinus bursa injections have a high degree of accuracy. Therefore, clinicians should consider using US-guidance for diagnostic or therapeutic pes anserinus bursa injections when indicated. Copyright © 2010 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.

  18. Distances to the subacromial bursa from 3 different injection sites as measured arthroscopically.

    Science.gov (United States)

    Sardelli, Matthew; Burks, Robert T

    2008-09-01

    The purpose of this study was to assess the distance for a standard needle to reach the subacromial bursa through 3 commonly used approaches. Thirty patients without associated rotator cuff tears underwent arthroscopic evaluation of the shoulder. The bursa was entered without shaving or altering of the bursa. By use of standard arthroscopic portals, a spinal needle was inserted from an anterior, lateral, and posterior position and measured to define the distance to the subacromial bursa from the skin. The mean distance with anterior needle placement was 2.9 +/- 0.6 cm. The mean distance with lateral needle placement was 2.9 +/- 0.7 cm. The mean distance with posterior needle placement was 5.2 +/- 1.1 cm. The mean body mass index for the group of patients was 27.5. The minimum was 18.7, and the maximum was 42.8. The distance to the subacromial bursa from the anterior and lateral approaches appears to be consistent and within reach of a standard 22- or 25-gauge needle. The distance to the subacromial bursa from a posterior approach appears to be almost double that of the anterior and lateral approaches and may not be reachable by standard 22- and 25-gauge needles in all patients. There appears to be no correlation between distances to the subacromial bursa from the anterior, lateral, or posterior approaches and the patient's body mass index. Given the relative distances measured to the subacromial bursa from the anterior, lateral, and posterior positions, clinicians may choose a longer needle to improve the accuracy of placement when approaching the subacromial bursa from a posterior position. Use of a standard-length needle will provide reasonable accuracy from the anterior and lateral positions.

  19. Comparison of 2 methods of centesis of the bursa of the biceps brachii tendon of horses.

    Science.gov (United States)

    Schumacher, J; Livesey, L; Brawner, W; Taintor, J; Pinto, N

    2007-07-01

    Centesis of the bicipital bursa using an 8.9 cm long spinal needle has been reported but the alternative of employing a 3.8 cm long hypodermic needle requires validation. To compare the efficacy of 2 different methods of centesis of the bicipital bursa and to evaluate the usefulness of ultrasonographic imaging to determine the location of solution administered when centesis of the bursa is attempted. For Trial 1, 6 clinicians, who had no previous experience of centesis of the bicipital bursa, attempted to inject a solution composed of an aqueous radiopaque contrast medium and physiological saline solution (PSS) into the bicipital bursae of 2/12 horses using the previously described distal approach to inject one bursa and a proximal approach to inject the contralateral bursa. The bicipital tendon and bursa were examined ultrasonographically before and after injection; and both shoulders were examined radiographically to identify the location of the medium. In Trial 2, another 6 clinicians, also with no previous experience of centesis, repeated Trial 1, using 6 horses, but the radiopaque contrast medium was mixed with air instead of PSS. Accuracy of centesis using the proximal approach was 39% and that of the distal approach 28%. Ultrasonographic examination of the shoulder allowed the location of solution and air to be accurately predicted in all 12 shoulders examined. Clinicians who have had no previous experience performing centesis of the bicipital bursa are unlikely to be successful in centesis using either approach. Radiographic examination after injecting a radiopaque contrast medium may be necessary to assess the success of centesis especially if bursal fluid is not obtained during centesis. Injecting air along with the radiopaque contrast medium provides more accurate ultrasonographic confirmation of centesis and better radiographic definition than does injection without air.

  20. Endoscopic resection of the inflamed bicipitoradial bursa extended around the radial neck.

    Science.gov (United States)

    Lui, Tun Hing

    2013-05-22

    The bicipitoradial bursa lies at the insertion of the biceps tendon on the radial tuberosity. It is an unusual site for chronic bursitis and most often, results from repetitive mechanical trauma or overuse. Other causes include tuberculosis, immunological complications of the rheumatological disease, for example, psoriatic arthropathy, rheumatoid arthritis and synovial chondromatosis. Unlike ganglion cyst arising from the elbow joint, resection of the bursa through the elbow arthroscopy is not possible as the bursa is not communicated with the joint. We reported a patient with rheumatoid arthritis presenting with bicipitoradial bursitis extended around the radial neck which was successfully resected endoscopically.

  1. Swelling of olecranon bursa in uremic patients receiving hemodialysis.

    Science.gov (United States)

    Handa, S. P.; Khaliq, S. U.

    1978-01-01

    Three patients with chronic renal failure who received therapy with hemodialysis through arteriovenous fistulas in the forearm had fluctuating swelling over the elbow on the same side as the fistula used for the dialysis. The clinical findings in each case were compatible with olecranon bursitis with effusion. The aspirate obtained from the swellings contained lymphocytes, polymorphonuclear leukocytes and histiocytes, a finding similar to that in cases of uremic pericardial and pleural effusion. Biopsy of the bursa in one case showed hyalinized collagenous tissue with infiltration by histiocytes and lymphocytes, reflecting underlying chronic inflammation. Uremia was believed to be the causative factor. Bursitis with effusion is considered to be one of the clinical aspects of uremic polyserositis. Images FIG. 1 FIG. 2 PMID:638913

  2. ANALISIS MONDAY EFFECT DAN ROGALSKI EFFECT DI BURSA EFEK JAKARTA

    Directory of Open Access Journals (Sweden)

    Dwi Cahyaningdyah

    2010-09-01

    Full Text Available Penelitian ini bertujuan untuk menguji pengaruh hari perdagangan di Bursa Efek Indonesia dengan menggunakan 70 saham yang aktif di perdagangkan selama periode penelitian 2004-2006. Teknik sampling menggunakan purposive sampling dengan kriteria sampel adalah saham-saham yang aktif diperdagangkan selama periode penelitian. Pengujian hipotesis menggunakan regresi dengan variable dummy. Hasil penelitian mengindikasikan bahwa ada pengaruh hari perdagangan terhadap return saham di Bursa Efek Indonesia. Return tertinggi terjadi pada hari Jumat dan return terendah pada hari Senin. Dengan hasil tersebut, dapat dikatakan penelitian ini berhasil mengidentifikasi adanya Monday effect dan weekend effect. Pengujian Rogalski effect menunjukkan bahwa Rogalski effect terjadi pada bulan April. The paper investigates the day of the week effect in Indonesia Stock Exchange by using 70 active stocks during the period of 2004-2006. Sampling technique uses purposive sampling and the criteria of the sample is stocks which are trading actively during the period of study. Regression with dummy variables are use to test the hypothesis.  The findings indicate that there is a day of the week effect in Indonesia  Stock exchange, the highest returns are observed on Friday and the lowest returns are observed on Monday. It can be said that this study can identify Monday effect and weekend effect in Jakarta Stock Exchange. The Investigation about Rogalski effect  in JSX find that Rogalski effect presents in April.  Monday’s return being positive in April and remain negative in the other months, so Monday effect disappeared in April.

  3. Patella tendon rupture after arthroscopic resection of the prepatellar bursa--a case report.

    Science.gov (United States)

    Epstein, David M; Capeci, Craig M; Rokito, Andrew S

    2010-01-01

    The use of arthroscopic techniques for excision of the pre-patellar bursa has become more common in recent years for the treatment of prepatellar bursitis. The current literature includes several case series that report few complications with this technique. We report the case of a 73-year-old male who sustained a low-energy patella tendon rupture 2 months after arthroscopic resection of the prepatellar bursa. We hypothesize that during arthroscopic excision of the prepatellar bursa there was an iatrogenic injury to the patellar tendon, which contributed to the subsequent rupture. Surgical repair was successfully performed using an open technique with a 1-year follow-up. To our knowledge, this is the first case report of patella tendon rupture following arthroscopic excision of the prepatellar bursa.

  4. Blood supply of the subacromial bursa and rotator cuff tendons on the bursal side.

    Science.gov (United States)

    Põldoja, Elle; Rahu, Madis; Kask, Kristo; Weyers, Imke; Kolts, Ivo

    2017-07-01

    Vascularity of the subacromial bursa and rotator cuff tendons is key factors in the pathogenesis of subacromial bursitis and impingement syndrome, rotator cuff tendinitis, and rotator cuff tears. The purpose of this study was to investigate and describe blood supply to the cranial and caudal parts of the subacromial bursa and the vascularity of the rotator cuff tendons on the bursal side. Fourteen fresh cadaveric shoulders from six females and eight males with a mean age of 71.7 (±10.8) years were studied. Before dissection, an arterial injection of 10% aqueous dispersion of latex was administered. Post-injection, the shoulders were fixed in an alcohol-formalin-glycerol solution. The cranial and caudal bursa of all specimens was mainly supplied by the thoracoacromial, suprascapular, and anterior and posterior circumflex humeral arteries. The cranial part of the bursa was supplied anteriorly by the thoracoacromial artery, and posteriorly and medially by the posterior circumflex humeral artery as far as the medial third. The caudal part received arterial blood anteriorly from the anterior circumflex humeral artery, and posteriorly and medially by the posterior circumflex humeral artery as far as the medial third of the caudal bursa. In addition, the suprascapular artery branched at the upper surface of the coracohumeral ligament, and the subcoracoid artery branched at the under surface of the same ligament. The subacromial bursa appears well vascularized. The results of the present investigation showed that blood supply to the subacromial bursa at the caudal part and rotator cuff tendons on the bursal side was linked to the same arteries. The subcoracoid artery supplied interval rotator structures close to the caudal bursa. It is the wish of the authors that this meticulous anatomical work will help surgeons in their day-to-day clinical work, e.g. to minimize the risk of complications such as perioperative bleeding.

  5. Endoscopic evaluation of the navicular bursa: observations, treatment and outcome in 92 cases with identified pathology.

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    Smith, M R W; Wright, I M

    2012-05-01

    Diagnostic navicular bursoscopy has been described in limited cases. Review of greater numbers is needed to define its contribution to case management and prognostic values. To report: 1) clinical, diagnostic and endoscopic findings in a series of cases, 2) surgical techniques and case outcomes and 3) prognostic values. The authors hypothesise: 1) lameness localising to the navicular bursa is commonly associated with dorsal border deep digital flexor tendon (DDFT) lesions, 2) endoscopy allows extent of injuries to be assessed and treated, 3) case outcome relates to severity of DDFT injury and 4) the technique is safe and associated with little morbidity. All horses that underwent endoscopy of a forelimb navicular bursa for investigation of lameness were identified. Case files were reviewed and those with injuries within the bursa selected for further analysis. One-hundred-and-fourteen horses were identified. Ninety-two had injuries within the bursa and DDFT injuries were identified in 98% of bursae. Of those examined with magnetic resonance imaging (MRI), 56% had combination injuries involving the DDFT and navicular bone. Sixty-one percent of horses returned to work sound, 42% returned to previous performance. Horses with extensive tearing and combination injuries of the DDFT and navicular bone identified with MRI, had worse outcomes. Lameness localising to the navicular bursa is commonly associated with injuries to the dorsal border of the DDFT. Endoscopy permits identification and characterisation of injuries within the navicular bursa and enables lesion management. Outcome following debridement is related to severity of injury but overall is reasonable. Horses with lameness localising to the navicular bursa may have tears of the DDFT. Bursoscopy is able to contribute diagnostic and prognostic information and debridement of lesions improves outcome compared to cases managed conservatively. © 2011 EVJ Ltd.

  6. Development of a Novel Medial Synoviocentesis Approach to the Bicipital Bursa in an Equine Cadaver Model.

    Science.gov (United States)

    Grabski, Milosz; McNamara, Jennifer; Roper, Darren; Warren-Smith, Chris; Busschers, Evita

    2016-05-01

    To describe the volume and dimensions of the bicipital bursa and its position in relation to bony and soft tissue structures, in order to develop a novel medial synoviocentesis approach to the bicipital bursa. Cadaveric study. Adult equine cadaver limbs (n=19). Bicipital bursa dimensions, volume, and relationship to bony structures were obtained from positive contrast computed tomography images after distension of the bursa (n=7). Following an intra-bursal injection of polyurethane resin, the bicipital bursa (n=4) was dissected and its relationship to soft tissue structures described. After computed tomography and dissection, a novel medial bicipital bursocentesis approach was investigated on intact cadavers (n=8). Median (range) of measurements were: length 9.02 cm (8.48-9.45 cm); width 7.06 cm (6.71-8.01 cm); and volume 51 mL (45-58 mL). The medial aspect of the bicipital bursa was located at the junction of the subclavius and biceps muscles, which corresponds with the externally visible lateral pectoral sulcus. Needle insertion 5-10 mm craniolateral to the center of the lateral pectoral sulcus midway between the palpable distal aspect of the deltoid tuberosity and the cranial part of the greater tubercle was found to be a reliable landmark for the novel medial bursocentesis approach. This approach was successful in all cadavers. The novel approach to the bicipital bursa provided access to the medial aspect of the bursa and is an alternative to the lateral approaches. Further validation in live horses is warranted to establish the safety and efficacy of this technique. © Copyright 2016 by The American College of Veterinary Surgeons.

  7. Intermetatarsal bursa primary synovial chondromatosis: case report and review of the literature.

    Science.gov (United States)

    Trevino, Manuel; Laks, Shaked; Kafchinski, Lisa; Sundarakumar, Dinesh K; Smith, Crysela M

    2017-12-01

    Primary synovial chondromatosis is a benign neoplastic process, occurring mostly in large joints, more rarely in tendon sheaths, and extremely uncommonly in bursae. We describe a patient with primary synovial chondromatosis arising in the fourth intermetatarsal bursa. Knowledge of the bursal anatomy of the forefoot, and of characteristic imaging findings and the pathogenesis of synovial chondromatosis, is essential in including this uncommon entity in the differential when occurring in unusual locations.

  8. Arthroscopic treatment for synovial chondromatosis of the subacromial bursa: a case report.

    Science.gov (United States)

    Park, Jung Ho; Noh, Haeng Kee; Bada, Leela P; Wang, Joon Ho; Park, Jong Woong

    2007-10-01

    Synovial chondromatosis of the subacromial bursa has been reported rarely. To the best of our knowledge, there was no case report of arthroscopic treatment for synovial chondromatosis of the subacromial bursa in English literature. The authors present a case of synovial chondromatosis of the subacromial space in a 45-year-old male, which was managed by arthroscopy. This rare condition can be well managed on similar lines as the other joints through arthroscopic surgery.

  9. Ruptured semimembranosus bursa--an unusual complication following sports injury of the knee.

    Science.gov (United States)

    Andersen-Ranberg, F; Hejgaard, N

    1986-01-01

    An exceptional complication of a slight sports injury of the knee with rupture of the semimembranosus bursa in a 29-year-old male football player is reported. The diagnosis was verified by immediate arthrography, consequently the possibility of thrombophlebitis could be ruled out. Anticoagulation is dangerous and contraindicated in rupture of the semimembranosus bursa due to the risk of developing compartment syndrome. Simple bed-rest for a week gave complete relief of pain. Images Fig. 1 PMID:3697597

  10. VERB PROCESSING IN BURSA LOCAL DIALECTS BURSA YERLİ AĞIZLARINDA FİİL İŞLETİMİ

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    Şükrü BAŞTÜRK

    2010-01-01

    Full Text Available The affixes used during the verb processing in the Turkey Turkish dialects show important phonetic variations. These affixes, which are commonly used in all the Turkey Turkish dialects, differ from one region to another, even from one village to another in the same region, in having varying phonetic characteristics. Of these affixes, those which undergo change most frequently and function as a key to the determination of the ethnic structure of the region in question are the future tense and present continuous tense suffixes. In Bursa local dialects, the final phoneme /r/ of the present continuous tense suffix –(Iyor predominantly was omitted and the neighboring vowel was lengthened. However, we observe that the initial vowel of the future tense suffix –AcAk was omitted and the back vowel /a/ was changed to the front vowel /e/ in the second syllable. We come across some different uses in the person suffixes following these suffixes. In this article, it is aimed to put forth various uses of the affixes in question and other verb processing affixes used in the local dialects of Bursa. Türkiye Türkçesi ağızlarında fiil işletimi sırasında kullanılan ekler, önemli fonetik değişiklikler göstermektedir. Bütün Türkiye Türkçesi ağızlarında ortak olarak kullanılan bu ekler, bölgeden bölgeye hatta aynı bölgede bulunan yakın köyler arasında farklı ses özellikleriyle kullanılmaktadır. Bu ekler arasında en çok değişikliğe uğrayan ve bölgenin etnik yapısını belirlemede anahtar konumunda olan ekler, gelecek zaman ve şimdiki zaman ekidir.Bursa yerli ağızlarında –(Iyor şimdiki zaman ekinin ağırlıklı olarak sonundaki r sesi düşürülmüş ve yanındaki ünlü uzatılmış biçimde kullanılmaktadır. Gelecek zaman eki –AcAk ise başındaki ünlü düşürülüp ikinci hecedeki ünlüsü inceltilmiş biçimde karşımıza çıkar. Bu eklerin kullandığı kişi eklerinde de bazı değişik kullan

  11. Increased substance P expression in the trochanteric bursa of patients with greater trochanteric pain syndrome.

    Science.gov (United States)

    Fearon, Angela Margaret; Twin, Jane; Dahlstrom, Jane E; Cook, Jill L; Cormick, Wes; Smith, Paul N; Scott, Alexander

    2014-10-01

    Greater trochanteric pain syndrome (GTPS) is a pathology that can involve the trochanteric bursa or the tendons which attach to the greater trochanter. To clarify the potential importance of bursa versus tendon pathology and of substance P (SP) in contributing to pain in this condition tendon and bursa tissue biopsies were obtained from 34 patients with GTPS and 29 control subjects. Specimens were evaluated via light microscopy for histopathological and morphological differences, as well as using immunohistochemistry for macrophages (CD68), inflammatory cells (CD45) and SP. Bursa [stroma score, mean (SD): 4.18 (1.65) vs. 2.53 (1.61), p = 0.051] and tendon [Bonar score, mean (SD): GTPS mean (SD) 12.65 (2.0), control (10.43 (4.84), p = 0.04] from subjects with GTPS demonstrated more extensive signs of pathology than specimens from control subjects. There was a significantly greater presence of SP in the bursa (frequency: 9/12 vs. 6/16, p = 0.047), but not in the tendon (8/12 vs. 8/15, p = 0.484) of subjects with GTPS compared to controls. An increased presence of SP in the trochanteric bursa may be related to the pain associated with GTPS.

  12. Bacterial colonization of the ovarian bursa in dogs with clinically suspected pyometra and in controls.

    Science.gov (United States)

    Rubio, Alejandro; Boyen, Filip; Tas, Olaf; Kitshoff, Adriaan; Polis, Ingeborgh; Van Goethem, Bart; de Rooster, Hilde

    2014-10-15

    Septic peritonitis occurs relatively commonly in dogs. Secondary septic peritonitis is usually associated with perforation of intestines or infected viscera, such as the uterus in pyometra cases. The aim of this study was to evaluate the bacterial flora in the ovarian bursae of intact bitches as a potential source of contamination. One hundred forty dogs, clinically suspected of pyometra, were prospectively enrolled. The control group consisted of 26 dogs that underwent elective ovariohysterectomies and 18 dogs with mammary gland tumors that were neutered at the time of mastectomy. Bacteriology samples were taken aseptically at the time of surgery from the bursae and the uterus in all dogs. Twenty-two dogs that were clinically suspected of pyometra had sterile uterine content ("mucometra" cases); the remaining 118 had positive uterine cultures ("pyometra" cases) and septic peritoneal fluid was present in 10% of these cases. Of the 118 pyometra cases, 9 had unilateral and 15 had bilateral bacterial colonization of their ovarian bursae. However, the bacteria from the ovarian bursa were similar to those recovered from the uterine pus in only half of the cases. Furthermore, positive bursae were also seen in one mucometra dog (unilateral) and in four control dogs (two unilateral and two bilateral). The data illustrate that the canine ovarian bursa can harbor bacteria. The biological importance of these isolations remains unclear. Copyright © 2014 Elsevier Inc. All rights reserved.

  13. Nerve distributions in insertional Achilles tendinopathy - a comparison of bone, bursae and tendon.

    Science.gov (United States)

    Andersson, Gustav; Backman, Ludvig J; Christensen, Jens; Alfredson, Håkan

    2017-03-01

    In a condition of pain in the Achilles tendon insertion there are multiple structures involved, such as the Achilles tendon itself, the retrocalcaneal bursa and a bony protrusion at the calcaneal tuberosity called Haglund's deformity. The innervation patterns of these structures are scarcely described, and the subcutaneous calcaneal bursa is traditionally not considered to be involved in the pathology. This study aimed at describing the innervation patterns of the four structures described above to provide a better understanding of possible origins of pain at the Achilles tendon insertion. Biopsies were taken from 10 patients with insertional Achilles tendinopathy, which had pathological changes in the subcutaneous and retrocalcaneal bursae, a Haglund deformity and Achilles tendon tendinopathy as verified by ultrasound. The biopsies were stained using immunohistochemistry in order to delineate the innervation patterns in the structures involved in insertional Achilles tendinopathy. Immunohistochemical examinations found that the subcutaneous bursa scored the highest using a semi-quantitative evaluation of the degree of innervation when compared to the retrocalcaneal bursa, the Achilles tendon, and the calcaneal bone. These findings suggest that the subcutaneous bursa, which is traditionally not included in surgical treatment, may be a clinically important factor in insertional Achilles tendinopathy.

  14. An ultrasound-guided, tendon-sparing, lateral approach to injection of the navicular bursa.

    Science.gov (United States)

    Nottrott, K; De Guio, C; Khairoun, A; Schramme, M

    2017-09-01

    Navicular disease in the horse often requires injection of the navicular bursa. We have developed an ultrasound-guided, lateral needle approach to navicular bursocentesis, which avoids penetration of the deep digital flexor tendon (DDFT) and the need for radiographic control. To describe and evaluate the feasibility and efficacy of an ultrasound-guided, lateral bursocentesis technique. Cadaveric and in vivo experiments. The navicular bursa in 62 cadaveric forelimbs of 31 horses and in both forelimbs of 26 live horses, positioned with the foot flexed in a navicular block, were submitted to lateral, ultrasound-guided injection of 1.5 ml radiocontrast agent. Lateromedial radiographs were taken to locate the contrast. A second injection of 0.5 ml methylene blue was administered during needle withdrawal in cadaveric limbs to investigate the needle pathway during dissection. Contrast agent was successfully deposited in the navicular bursa in 104 of 114 (91%) limbs and in the navicular bursa alone in 89 of 114 (78%) limbs. Dissection showed no evidence of penetration of the DDFT in cadaver limbs. Failure to inject the navicular bursa was significantly associated with poor quality of the ultrasound image (P = 0.04) and resulted in aberrant injection of the distal interphalangeal joint in five of 114 (4%) limbs, the peribursal soft tissues in four of 114 (4%) limbs and the digital flexor tendon sheath in one of 114 (0.9%) limbs. Synovial fluid was observed at the needle hub in 58% of live horses. It is unknown whether injection results obtained in the limbs of horses without disease can be extrapolated to horses with clinical disease of the podotrochlear apparatus. The localisation of contrast medium on radiographs may not accurately reflect the behaviour of local anaesthetic solution or therapeutic medications injected in the navicular bursa. This lateral, ultrasound-guided technique for injecting the navicular bursa is effective, does not penetrate the DDFT and avoids

  15. Involvement of the anterior portion of the subacromial-subdeltoid bursa in the painful shoulder.

    Science.gov (United States)

    Stallenberg, Bernard; Destate, Nathalie; Feipel, Véronique; Gevenois, Pierre Alain

    2006-10-01

    The purpose of our study was to verify that increased widening of the anterior portion of the subacromial-subdeltoid bursa is associated with anteromedial shoulder pain. Bursography, sonography, and CT were performed in six cadaver shoulders and compared with anatomic sections in neutral position and while the humerus was extended and internally rotated. For the clinical study, the width of the anterior portion of the bursa was measured in both positions in both shoulders of 27 patients referred because of shoulder pain and in eight asymptomatic volunteers. Pain was coded as absent, experienced in the anteromedial portion of the shoulder, or experienced elsewhere but not anteromedially, and we compared the pain scores between shoulder positions. In all cadaver shoulders, when compared with CT scans and anatomic sections, sonography showed the morphology of the bursa, its relationships with surrounding structures, and morphologic changes associated with position. In volunteers, the mean width of the bursa was 0.74 +/- 0.05 and 0.93 +/- 0.09 mm (p = 0.013), respectively, in neutral and stress position. In patients, the same values were 0.70 +/- 0.07 and 0.81 +/- 0.14 mm (p = 0.286) in the asymptomatic side and 1.20 +/- 0.11 and 1.75 +/- 0.23 mm (p bursa was wider in patients experiencing pain anteromedially than in those who experienced pain elsewhere and volunteers (p = 0.002 and bursa was wider in symptomatic shoulders than in asymptomatic shoulders (p bursa is associated with anteromedial shoulder pain and the clinical syndrome of coracoid impingement.

  16. Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein.

    Science.gov (United States)

    Goutagny, Nadege; Jiang, Zhaozhao; Tian, Jane; Parroche, Peggy; Schickli, Jeanne; Monks, Brian G; Ulbrandt, Nancy; Ji, Hong; Kiener, Peter A; Coyle, Anthony J; Fitzgerald, Katherine A

    2010-02-01

    Human metapneumoviruses (HMPVs) are recently identified Paramyxoviridae that contribute to respiratory tract infections in children. No effective treatments or vaccines are available. Successful defense against virus infection relies on early detection by germ line-encoded pattern recognition receptors and activation of cytokine and type I IFN genes. Recently, the RNA helicase retinoic acid-inducible gene I (RIG-I) has been shown to sense HMPV. In this study, we investigated the abilities of two prototype strains of HMPV (A1 [NL\\1\\00] and B1 [NL\\1\\99]) to activate RIG-I and induce type I IFNs. Despite the abilities of both HMPV-A1 and HMPV-B1 to infect and replicate in cell lines and primary cells, only the HMPV-A1 strain triggered RIG-I to induce IFNA/B gene transcription. The failure of the HMPV-B1 strain to elicit type I IFN production was dependent on the B1 phosphoprotein, which specifically prevented RIG-I-mediated sensing of HMPV viral 5' triphosphate RNA. In contrast to most cell types, plasmacytoid dendritic cells displayed a unique ability to sense both HMPV-A1 and HMPV-B1 and in this case sensing was via TLR7 rather than RIG-I. Collectively, these data reveal differential mechanisms of sensing for two closely related viruses, which operate in cell type-specific manners.

  17. Chemical composition and biological screening of Capsella bursa-pastoris

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    Clara Grosso

    2011-06-01

    Full Text Available Capsella bursa-pastoris (L. Medik. (Brassicaceae is a wild herb with high nutritional value that can be eaten raw or cooked. A metabolomic study was performed with different extracts of its aerial parts that were tested concerning their antiradical, acetylcholinesterase inhibitory and antibacterial activities. Phenolic compounds were identified and quantified by HPLC-DAD, organic acids and amino acids were determined by HPLC-UV, while free fatty acids and sterols were analysed by GC-ITMS. The vegetal material was rich in kaempferol-3-O-rutinoside (mean value 2247.09 mg/kg of dry plant, quinic acid (95628.00 mg/kg of dry plant, arginine (mean value of 1.18 mg/kg of dry plant, palmitic acid (284.48 mg/kg and β-sitosterol (28%. The extracts presented a concentration-dependent antiradical activity (against DPPH•, O2•- and LOO•, being most effective against •NO (EC25 0.20 µg/mL. In addition, the extracts were also acetylcholinesterase inhibitors and antibacterial active, revealing that, besides the plant's good nutritional value, it presents important biological properties as well.

  18. Metabolic Syndrome among Women: A Study from Bursa Turkey

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    Hasan Orhan

    2011-08-01

    Full Text Available AIM: Obesity is one of the risk factors of metabolic syndrome (MetS and its prevalence is rapidly increasing in Turkey. The purpose of this study was to assess the prevalence of MetS and obesity among women aged 20 years and older. METHOD: This is a cross- sectional study, undergone in a primary health care setting in Bursa /Turkey in the year 2008. A total of 807 women were included in the study. Body weight, height, waist circumference, blood pressure, total and HDL cholesterol, fasting plasma glucose and triglyceride levels were measured. Metabolic Syndrome definition was made according to the International Diabetes Federation (IDF criteria. RESULTS: The mean age was 42.713.2 years, 96.4% were married, 50.7% had education of less than 8 years, 93.7% were housewives and 85.3% had a monthly family income of $650 or less. The prevalence of MetS and abdominal obesity were 17.5 % and 87.7% respectively. Those with diabetes mellitus and elevated plasma lipids had increased risk of developing MetS 11.3 and 4.5 times more than those without these situations respectively. The risk of MetS increases with age and increasing BMI. CONCLUSION: Obesity is an alarming risk factor for the development of MetS in our study group. [TAF Prev Med Bull 2011; 10(4.000: 421-432

  19. THE INVESTIGATION OF DEATHS IN NILUFER DISTRICT, BURSA

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    Erdinc OSMAN

    2006-08-01

    Full Text Available In the study performed for the purpose of stating deaths occuring in 2003 in Nilufer district, Bursa and evaluating the deaths in respect of setting (ICD 10 with the List of Brief General Death, 555 deaths in the recording of Nilufer Municipality were investigated. According to the results, three causes of deaths were heart failure (14,6 %, traffic accident (12,3 and cancers (%9,5. These causes in respect of ICD 10 the List of Brief General Death were other heart diseases (15,5%, symptoms or cases which is not defined clearly (13,7% and transportation accidents (12,3%. When the death reasons existed in recordings compared with the that of ICD 10 the List of Brief General Death, it was established that while 367 death reasons (66,1% were compatible, 188 reasons (33,9 % were uncompatible. The number of reports have reasons which were not death causes actually was % 33,5. In order to establish the causes of death exactly and truly, this subject should be emphasized in the training intended for doctors and medicine students. [TAF Prev Med Bull 2006; 5(4.000: 254-266

  20. Increased substance P in subacromial bursa and shoulder pain in rotator cuff diseases.

    Science.gov (United States)

    Gotoh, M; Hamada, K; Yamakawa, H; Inoue, A; Fukuda, H

    1998-09-01

    The subacromial bursa is recognized as a site associated with the shoulder pain caused by rotator cuff disease in the middle-aged and elderly. Substance P is contained in primary afferent nerves, and its quantity increases during chronic pain. The amount of substance P in the subacromial bursa of patients with rotator cuff disease was examined. Radioimmunoassay and immunohistochemistry were employed to quantify and localize substance P. The preoperative pain level was measured with a visual analogue scale with 0 as no pain, 5 as moderate, and 10 as severe. Thirty-seven patients that had undergone operation were divided into two groups: one composed of 19 patients with subacromial bursitis and a partial-thickness tear of the rotator cuff (nonperforated cuff) and the other composed of 18 patients with a full-thickness tear (perforated cuff). Subacromial bursae obtained from seven fresh cadavers with no shoulder pain before death were used as controls. The visual analogue scale showed significantly greater pain in the group with the nonperforated rotator cuff than in the group with the perforated cuff. Consistent with these results, the amount of substance P in the subacromial bursa was significantly greater in the former group than in the latter. Nerve fibers immunoreactive to substance P were localized around the vessels, with a larger number of fibers in the group with the nonperforated rotator cuff. Therefore, an increased amount of substance P in the subacromial bursa appears to correlate with the pain caused by rotator cuff disease.

  1. Inflammatory cytokines are overexpressed in the subacromial bursa of frozen shoulder.

    Science.gov (United States)

    Lho, Yun-Mee; Ha, Eunyoung; Cho, Chul-Hyun; Song, Kwang-Soon; Min, Byung-Woo; Bae, Ki-Cheor; Lee, Kyung-Jae; Hwang, Ilseon; Park, Hyung-Bin

    2013-05-01

    Frozen shoulder is a debilitating condition characterized by gradual loss of glenohumeral motion with chronic inflammation and capsular fibrosis. Yet its pathogenesis remains largely unknown. We hypothesized that the subacromial bursa may be responsible for the pathogenesis of frozen shoulder by producing inflammatory cytokines. We obtained joint capsules and subacromial bursae from 14 patients with idiopathic frozen shoulder and from 7 control subjects to determine the expression levels of interleukin (IL) 1α, IL-1β, IL-6, tumor necrosis factor α (TNF-α), cyclooxygenase (COX) 1, and COX-2 by real-time reverse transcriptase-polymerase chain reaction, immunohistochemistry, and enzyme-linked immunosorbent assay. IL-1α, IL-1β, TNF-α, COX-1, and COX-2 were expressed at significantly high levels in the joint capsules of the frozen shoulder group compared with those of the control group. Intriguingly, IL-1α, TNF-α, and COX-2 were also expressed at significantly high levels in the subacromial bursae of the frozen shoulder group compared with those of the control group. Immunohistochemical analysis showed increased expression of COX-2 in both the joint capsules and subacromial bursae of the frozen shoulder group. These findings imply that elevated levels of inflammatory cytokines in the subacromial bursa may be associated with the pathogenesis of inflammation evolving into fibrosis. Copyright © 2013 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Mosby, Inc. All rights reserved.

  2. Steroid diffusion into the navicular bursa occurs in horses affected by palmar foot pain.

    Science.gov (United States)

    Manfredi, J M; Boyce, M; Malone, E D; Anderson, C; Anderson, L B; Trumble, T N

    Palmar foot pain is frequently treated by steroid injections into the distal interphalangeal joint (DIPJ) in the anticipation that the steroid will diffuse to the navicular bursa and palmar foot structures. The object of this study was to determine if triamcinolone acetonide (TA) would in fact be able to locally diffuse from the DIPJ into the navicular bursa in horses affected by palmar foot pain. Both forelimb DIPJs (nine horses) were injected with 10 mg of TA. Navicular bursa fluid samples, both forelimb and one hind limb (systemic control), were analysed for TA with high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) six hours later. Foot radiographs were graded (0-4) on severity of changes. Forelimb navicular bursa TA concentrations (mean±sd log(10), 3.20±0.56) were significantly higher than systemic control concentrations (mean±sd log(10), 1.89±0.3) (P2 were four times as likely to have TA log(10) concentrations less than 3.2 (158.49 ng/ml). TA locally diffused from the DIPJ into the navicular bursa in horses affected by palmar foot pain; TA concentrations decreased as radiographic severity increased.

  3. Research of Internal Migration by Compartment Models: The Case of Erzurum-Bursa

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    Fatih Çakmak

    2017-04-01

    Full Text Available Migration, which consists of quite complex components, is a concept subjected in many scientific research areas. Internal migration refers a migration occurred in the boundaries of a country. Migration in Turkey usually tends to be directed towards larger and more industrialized provinces. Nevertheless, there exists a density on the direction of certain provinces such as migration from Erzurum to Bursa. Nowadays, the proceeding of the migration flows between Erzurum and Bursa since 1980’s is another point which necessitates to be examined. The purpose of this study is to investigate the migration between Erzurum and Bursa by using compartment models in the 1980-2015 period. The paper performs compartment models to explain the changes of migration flows in terms of gross domestic product, unemployment rate, and time. According to the results, there is a significant increase in migration from Erzurum to Bursa depending on the time of migration and unemployment rate. Nonetheless, there is no significant change related with the gross domestic product. In addition, the study has shown that migration increases as unemployment rate decreases; but there is no significant change in migration depending on time and gross domestic product from Bursa to Erzurum.

  4. PENGARUH LEVERAGE, PROFITABILITAS DAN SIZE TERHADAP PENGUNGKAPAN CORPORATE SOCIAL RESPONSIBILITY PADA PERUSAHAAN DI BURSA EFEK INDONESIA

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    syailend eka saputra

    2016-10-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui pengaruh leverage, profitabilitas dan size terhadap jumlah pengungkapan corporate social responsibility. Pada penelitian ini digunakan beberapa perusahaan high profile di Bursa Efek Indonesia. Periode penelitian yang digunakan dari tahun 2010 sampai 2014. Didalam penelitian ini variabel penelitian yang digunakan adalah leverage yang diukur dengan debt to equity ratio, profitabilitas diukur dengan menggunakan return on assets dan size diukur dengan LN total assets. Proses pengujian hipotesis dilakukan dengan menggunakan regresi panel yang diolah dengan menggunakan Eviews. Berdasarkan hasil pengujian ditemukan bahwa leverage dan profitabilitas berpengaruh sigbifikan terhadap pengungkapan corporate social responsibility pada perusahaan high profile di Bursa Efek Indonesia sedangkan size tidak berpengaruh signifikan terhadap jumlah pengungkapan corporate social responsibility pada perusahaan high profile di Bursa Efek Indonesia.

  5. Increased IL-1beta expression and myofibroblast recruitment in subacromial bursa is associated with rotator cuff lesions with shoulder stiffness.

    Science.gov (United States)

    Ko, Jih-Yang; Wang, Feng-Sheng; Huang, Hsuan-Ying; Wang, Ching-Jen; Tseng, Shin-Ling; Hsu, Chin

    2008-08-01

    We evaluated whether proinflammatory cytokine expression and myofibroblast recruitment in subacromial bursa was linked to rotator cuff lesions with shoulder stiffness. We analyzed expressions of IL-1beta, IL-6, and TNF-alpha in subacromial bursa and joint fluid collected from 14 patients with cuff tears with stiffness as a study group (Group I) and 14 patients with rotator cuff tears without shoulder stiffness as a control group (Group II) using real-time RT-PCR, immunohistochemistry, and ELISA. Myofibroblast apoptosis in subacromial bursa was analyzed using terminal deoxynucleotidyl transferase -mediated deoxyuridine triphosphate-biotin nick end-labeling (TUNEL) and alpha-smooth muscle actin immunofluorescence staining. Shoulder function was evaluated using the Constant score. Group I had higher mRNA expression (p bursa and IL-1beta levels in joint fluid were correlated with a preoperative deficit in shoulder motion (p bursa in rotator cuff lesions are linked to shoulder stiffness.

  6. Earning Management dan Expected Future Earning di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Taofiq Rachmat

    2017-09-01

    expected future earning yang rendah. Berdasarkan hasil penelitian ini, pemangku kepentingan disarankan menggunakan M-score ketika melakukan penilaian pada laporan keuangan.Kata kunci: earning management, expected future earning, bursa efek indonesia, m-score, data panel 

  7. MR imaging after therapeutic injection of the subacromial bursa

    Energy Technology Data Exchange (ETDEWEB)

    Major, N.M. [Duke University Medical Center, Department of Radiology, Division Musculoskeletal, Durham, NC (United States)

    1999-11-01

    Objective. As a therapeutic injection into the subacromial bursa (SAB) is commonly performed for impingement syndrome, it is important to know whether this fluid can be retained for a period of time and cause confusion with a pathologic collection of fluid. This study identifies and describes the appearance of recent subacromial injection using MR imaging, and the appearance of a potential complication.Design and patients. Fourteen asymptomatic shoulders were studied with MR imaging using fast spin echo T2-weighted imaging (1.5 T) prior to injection with 7 cm{sup 3} of xylocaine. Four shoulders had subacromial fluid and were eliminated from the study. The remaining 10 (9 men, 1 woman; age range 27-36 years, average age 33 years) were then re-imaged immediately, and at 6, 12 and 24 h after the injection or until fluid resolved. Each set of images was reviewed for the presence of fluid in the SAB and for additional abnormalities.Results. Fluid was identified in all subjects in the SAB in the immediate, 6 and 12 h post-injection images. At 24 h, fluid was not identified within the SAB in eight of 10 patients. In one patient fluid resolved in 48 h. The other continued to demonstrate fluid in the SAB and in the joint as well as abnormal signal in the infraspinatus muscle from a presumed myositis. Imaging was performed up to 10 days after the injection in this patient.Conclusions. It is known that fluid identified in the SAB without evidence of a cuff tear may be due to bursitis. However, if MR imaging is performed within 24 h of injection, the presence of the fluid may be iatrogenic. In addition, the history of recent therapeutic injection is very important as complications such as myositis can occur as a result of the injection. Knowledge of injection prior to imaging is vital for accurate interpretation of MR shoulder examinations. (orig.)

  8. Electrical and Electronical Waste Generation in Turkey: Bursa Case Study

    Directory of Open Access Journals (Sweden)

    Güray SALİHOĞLU

    2016-10-01

    Full Text Available Electrical and electronical equipment that gradually take more place in our daily life, spend their service life in short times and become an e-waste problem to be solved.  Because of the hazardous components they contain, e-waste can cause environmental and human health threats if they are not properly managed. If they are managed properly, they can be a valuable raw material source, since they contain valuable metals such as copper, silver, gold, palladium and recyclable components such as plastics and metals. According to a research conducted in 2014, the global e-waste amount accounts to a source worth 52 billion $; however, only 16% of this source has been properly recycled. It is important to know the potential e-waste amount and the behaviors of people in the production of e-waste to realize a proper e-waste management in our country. The amount and property of electrical and electronic equipment and e-waste generation potential per person in Bursa was investigated in this study. A questionnaire was prepared and applied to a group of people including 31 families (100 person. The questions were to investigate the behaviors in the use, replacement, and management of electrical and electronical equipment. The findings showed that usage of lamps (fluorescent and others were higher than the other equipment, and usage of mobile phones were found to be highest in terms of devices. It was also found that when the mobiles become e-waste since the owners do not want to use them, they are not just thrown away and kept at homes instead. E-waste generation potential of a person from the families investigated was estimated to be 8.14 kg/year.

  9. Multipotent Mesenchymal Stem Cells from Human Subacromial Bursa: Potential for Cell Based Tendon Tissue Engineering

    Science.gov (United States)

    Song, Na; Armstrong, April D.; Li, Feng; Ouyang, Hongsheng

    2014-01-01

    Rotator cuff injuries are a common clinical problem either as a result of overuse or aging. Biological approaches to tendon repair that involve use of scaffolding materials or cell-based approaches are currently being investigated. The cell-based approaches are focused on applying multipotent mesenchymal stem cells (MSCs) mostly harvested from bone marrow. In the present study, we focused on characterizing cells harvested from tissues associated with rotator cuff tendons based on an assumption that these cells would be more appropriate for tendon repair. We isolated MSCs from bursa tissue associated with rotator cuff tendons and characterized them for multilineage differentiation in vitro and in vivo. Human bursa was obtained from patients undergoing rotator cuff surgery and cells within were isolated using collagenase and dispase digestion. The cells isolated from the tissues were characterized for osteoblastic, adipogenic, chondrogenic, and tenogenic differentiation in vitro and in vivo. The results showed that the cells isolated from bursa tissue exhibited MSCs characteristics as evidenced by the expression of putative cell surface markers attributed to MSCs. The cells exhibited high proliferative capacity and differentiated toward cells of mesenchymal lineages with high efficiency. Bursa-derived cells expressed markers of tenocytes when treated with bone morphogenetic protein-12 (BMP-12) and assumed aligned morphology in culture. Bursa cells pretreated with BMP-12 and seeded in ceramic scaffolds formed extensive bone, as well as tendon-like tissue in vivo. Bone formation was demonstrated by histological analysis and immunofluorescence for DMP-1 in tissue sections made from the scaffolds seeded with the cells. Tendon-like tissue formed in vivo consisted of parallel collagen fibres typical of tendon tissues. Bursa-derived cells also formed a fibrocartilagenous tissue in the ceramic scaffolds. Taken together, the results demonstrate a new source of MSCs with a

  10. Lipoma arborescens associated with osseous/chondroid differentiation in subdeltoid bursa.

    Science.gov (United States)

    Kim, Ryuh Sup; Kim, Young Tae; Choi, Jong Min; Shin, Sang Hyun; Kim, Yeo Ju; Kim, Lucia

    2013-07-01

    Lipoma arborescens (LA) is a rare benign lesion of unknown etiology. It is characterized histologically by villous proliferation of the synovial membrane and diffuse replacement of the subsynovial tissue by mature fat cells. This condition affects the knee joint most commonly. Cases involving other locations including glenohumeral joint,[1] hip,[2] elbow,[3] hand[4] and ankle[5] have been rarely described. Involvement of the subdeltoid bursa has also been reported, but to date no case has described LA with osseous/chondroid differentiation of this bursa. Another significant finding in our case was the coexistence of LA with intermuscular lipoma, SLAP lesion and labral cyst.

  11. Dynamic enhanced MRI of the subacromial bursa: correlation with arthroscopic and histological findings

    Energy Technology Data Exchange (ETDEWEB)

    Matsuzaki, S. [Dept. of Radiology, Osaka Kosei-nenkin Hospital (Japan); Yoneda, M. [Shoulder and Sports Medicine Service, Osaka Kosei-nenkin Hospital, Osaka City, Osaka (Japan); Kobayashi, Y. [Dept. of Pathology, Osaka Kosei-nenkin Hospital (Japan); Fukushima, S. [Dept. of Orthopaedic Surgery, Sapporo Tokeidai Hospital, Osaka (Japan); Wakitani, S. [Dept. of Orthopaedic Surgery, Shinsyu Univ., Matsumato (Japan)

    2003-09-01

    Objective: To assess dynamic MRI with Gd-DTPA enhancement for evaluating inflammatory changes in the subacromial bursa. Design and patients: We detected the signal intensity changes in dynamic MRI of the subacromial bursa, and confirmed these macroscopically by arthroscopy and histologically. The signal intensity was measured using built-in software, and the enhancement ratio (E ratio) was calculated from dynamic MR images. In addition, as a parameter of the rate of the increase in the signal intensity from 0 to 80 s, the mean increase per second in the E ratio was obtained as the coefficient of enhancement (CE). The correlation was studied of the E ratio and CE with the arthroscopic findings (redness, villous formation, thickening and adhesion), and of the E ratio and CE with the histological findings (capillary proliferation, papillary hyperplasia, fibrosis and inflammatory cell infiltration) of the subacromial bursa. Of patients with shoulder pain, this study included those with rotator cuff injury; patients with rheumatoid arthritis or pitching shoulder disorders were excluded. There were 27 patients (15 men, 12 women) ranging in age from 25 to 73 years (mean 49.1 years). Dynamic MRI of the shoulder was also performed on the healthy side of 10 patients and in five normal young volunteers. Results and conclusions: Changes in signal intensity on dynamic MRI were measured in the subacromial bursa. The E ratio (80 s) and CE (0-80 s) were significantly correlated with redness and villous formation as arthroscopic findings, positively correlated with capillary proliferation and papillary hyperplasia as histological findings (p < 0.05), and negatively correlated with fibrosis as a histological finding (p < 0.05) in the subacromial bursa. The patterns of dynamic curves were well correlated with the bursoscopic and histological findings of the synovium of the subacromial bursa. Dynamic MRI appears to correlate with inflammatory activity of synovium of the subacromial

  12. One Dose of Staphylococcus aureus 4C-Staph Vaccine Formulated with a Novel TLR7-Dependent Adjuvant Rapidly Protects Mice through Antibodies, Effector CD4+ T Cells, and IL-17A.

    Science.gov (United States)

    Mancini, Francesca; Monaci, Elisabetta; Lofano, Giuseppe; Torre, Antonina; Bacconi, Marta; Tavarini, Simona; Sammicheli, Chiara; Arcidiacono, Letizia; Galletti, Bruno; Laera, Donatello; Pallaoro, Michele; Tuscano, Giovanna; Fontana, Maria Rita; Bensi, Giuliano; Grandi, Guido; Rossi-Paccani, Silvia; Nuti, Sandra; Rappuoli, Rino; De Gregorio, Ennio; Bagnoli, Fabio; Soldaini, Elisabetta; Bertholet, Sylvie

    2016-01-01

    A rapidly acting, single dose vaccine against Staphylococcus aureus would be highly beneficial for patients scheduled for major surgeries or in intensive care units. Here we show that one immunization with a multicomponent S. aureus candidate vaccine, 4C-Staph, formulated with a novel TLR7-dependent adjuvant, T7-alum, readily protected mice from death and from bacterial dissemination, both in kidney abscess and peritonitis models, outperforming alum-formulated vaccine. This increased efficacy was paralleled by higher vaccine-specific and α-hemolysin-neutralizing antibody titers and Th1/Th17 cell responses. Antibodies played a crucial protective role, as shown by the lack of protection of 4C-Staph/T7-alum vaccine in B-cell-deficient mice and by serum transfer experiments. Depletion of effector CD4+ T cells not only reduced survival but also increased S. aureus load in kidneys of mice immunized with 4C-Staph/T7-alum. The role of IL-17A in the control of bacterial dissemination in 4C-Staph/T7-alum vaccinated mice was indicated by in vivo neutralization experiments. We conclude that single dose 4C-Staph/T7-alum vaccine promptly and efficiently protected mice against S. aureus through the combined actions of antibodies, CD4+ effector T cells, and IL-17A. These data suggest that inclusion of an adjuvant that induces not only fast antibody responses but also IL-17-producing cell-mediated effector responses could efficaciously protect patients scheduled for major surgeries or in intensive care units.

  13. One Dose of Staphylococcus aureus 4C-Staph Vaccine Formulated with a Novel TLR7-Dependent Adjuvant Rapidly Protects Mice through Antibodies, Effector CD4+ T Cells, and IL-17A.

    Directory of Open Access Journals (Sweden)

    Francesca Mancini

    Full Text Available A rapidly acting, single dose vaccine against Staphylococcus aureus would be highly beneficial for patients scheduled for major surgeries or in intensive care units. Here we show that one immunization with a multicomponent S. aureus candidate vaccine, 4C-Staph, formulated with a novel TLR7-dependent adjuvant, T7-alum, readily protected mice from death and from bacterial dissemination, both in kidney abscess and peritonitis models, outperforming alum-formulated vaccine. This increased efficacy was paralleled by higher vaccine-specific and α-hemolysin-neutralizing antibody titers and Th1/Th17 cell responses. Antibodies played a crucial protective role, as shown by the lack of protection of 4C-Staph/T7-alum vaccine in B-cell-deficient mice and by serum transfer experiments. Depletion of effector CD4+ T cells not only reduced survival but also increased S. aureus load in kidneys of mice immunized with 4C-Staph/T7-alum. The role of IL-17A in the control of bacterial dissemination in 4C-Staph/T7-alum vaccinated mice was indicated by in vivo neutralization experiments. We conclude that single dose 4C-Staph/T7-alum vaccine promptly and efficiently protected mice against S. aureus through the combined actions of antibodies, CD4+ effector T cells, and IL-17A. These data suggest that inclusion of an adjuvant that induces not only fast antibody responses but also IL-17-producing cell-mediated effector responses could efficaciously protect patients scheduled for major surgeries or in intensive care units.

  14. Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes.

    Science.gov (United States)

    Ablasser, Andrea; Poeck, Hendrik; Anz, David; Berger, Michael; Schlee, Martin; Kim, Sarah; Bourquin, Carole; Goutagny, Nadege; Jiang, Zhaozhao; Fitzgerald, Katherine A; Rothenfusser, Simon; Endres, Stefan; Hartmann, Gunther; Hornung, Veit

    2009-06-01

    Detection of non-self RNA by TLRs within endosomes and by retinoic acid-inducible gene I (RIG-I)-like helicases in the cytosol is central to mammalian antiviral immunity. In this study, we used pathway-specific agonists and targeted delivery to address RNA immunorecognition in primary human immune cells. Within PBMC, plasmacytoid dendritic cells (pDC) and monocytes were found to be responsible for IFN-alpha production upon immunorecognition of RNA. The mechanisms of RNA recognition in pDC and monocytes were distinct. In pDC, recognition of ssRNA and dsRNA oligonucleotides was TLR7-dependent, whereas a 5' triphosphate moiety (RIG-I ligand activity) had no major contribution to IFN-alpha production. In monocytes, the response to RNA oligonucleotides was mediated by either TLR8 or RIG-I. TLR8 was responsible for IL-12 induction upon endosomal delivery of ssRNA oligonucleotides and RIG-I was responsible for IFN-alpha production upon delivery of 5' triphosphate RNA into the cytosol. In conclusion, the dissection of these pathways by selecting the appropriate structure and delivery of RNA reveals pDC as major producer of IFN-alpha upon TLR-mediated stimulation and monocytes as major producer of IFN-alpha upon RIG-I-mediated stimulation. Furthermore, our results uncover the potential of monocytes to function as major producers of IL-12p70, a key Th1 cytokine classically ascribed to myeloid dendritic cells that cannot be induced by CpG oligonucleotides in the human system.

  15. Ex Vivo Assessment of an Ultrasound-Guided Injection Technique of the Navicular Bursa in the Horse.

    Science.gov (United States)

    Perrin, R; Diguet, A C; Cantet, P; Bailly, C; Brogniez, L; Dugdale, A; Nisolle, J F; Vandeweerd, J M

    2016-12-01

    Synovitis of the navicular bursa is common in performance horses. The objective of this study was to describe an ultrasound-guided technique to inject a distended navicular bursa and to evaluate its feasibility for use by a clinician not trained in the technique. Twenty distal limbs of horses of various breeds and sizes were used. To produce synovial distension, the navicular bursa of each limb was injected with contrast medium using a lateral approach and radiography was performed to confirm that the contrast medium was distending the bursa. The digit was positioned with the distal interphalangeal joint in hyperextension. A microconvex ultrasound probe was placed in the hollow of the pastern, palmar to the middle phalanx and the region was assessed in a transverse plane slightly oblique to the horizontal plane. The ultrasound probe was rotated to visualize both the lateral and medial recesses and to select which side was more distended to inject. A 21G 0.8 × 50 mm needle was inserted abaxially to the probe in the plane of the ultrasound beam into the proximal recess of this navicular bursa and a methylene blue solution was injected. Following injection, dissection was performed to assess whether the navicular bursa had been successfully injected. This ultrasound-guided technique was reliably performed with a success rate of 68%. The success of injection is influenced by hyperextension of the foot, quality of ultrasound images and degree of distension of the bursa. © 2015 Blackwell Verlag GmbH.

  16. Ground Motion Simulations for Bursa Region (Turkey) Using Input Parameters derived from the Regional Seismic Network

    Science.gov (United States)

    Unal, B.; Askan, A.

    2014-12-01

    Earthquakes are among the most destructive natural disasters in Turkey and it is important to assess seismicity in different regions with the use of seismic networks. Bursa is located in Marmara Region, Northwestern Turkey and to the south of the very active North Anatolian Fault Zone. With around three million inhabitants and key industrial facilities of the country, Bursa is the fourth largest city in Turkey. Since most of the focus is on North Anatolian Fault zone, despite its significant seismicity, Bursa area has not been investigated extensively until recently. For reliable seismic hazard estimations and seismic design of structures, assessment of potential ground motions in this region is essential using both recorded and simulated data. In this study, we employ stochastic finite-fault simulation with dynamic corner frequency approach to model previous events as well to assess potential earthquakes in Bursa. To ensure simulations with reliable synthetic ground motion outputs, the input parameters must be carefully derived from regional data. In this study, using strong motion data collected at 33 stations in the region, site-specific parameters such as near-surface high frequency attenuation parameter and amplifications are obtained. Similarly, source and path parameters are adopted from previous studies that as well employ regional data. Initially, major previous events in the region are verified by comparing the records with the corresponding synthetics. Then simulations of scenario events in the region are performed. We present the results in terms of spatial distribution of peak ground motion parameters and time histories at selected locations.

  17. An optimised injection technique for the navicular bursa that avoids the deep digital flexor tendon.

    Science.gov (United States)

    Daniel, A J; Goodrich, L R; Barrett, M F; Werpy, N M; Morley, P S; McIlwraith, C W

    2016-03-01

    Injection of the navicular bursa is commonly performed from the palmar aspect of the limb, which results in penetration of the deep digital flexor tendon (DDFT). To report a radiographic guided injection from the lateral aspect of the limb that avoids puncture of the DDFT and to assess synovial and soft tissue penetration by the needle. Prospective clinical and cadaveric study. Prospective analysis of cadaver limbs and clinical cases in which the navicular bursa was injected from the lateral aspect. Cadaver limbs were placed in a stand to simulate weight bearing and injection was performed in limbs without synovial distension or with distension of either the distal interphalangeal (DIP) joint, digital flexor tendon sheath (DFTS) or navicular bursa. In cadaver and clinical limbs, contrast was injected and the needle position assessed with radiographs. Cadaver (but not clinical) limbs were also examined using magnetic resonance imaging with the needle in situ. Successful navicular bursal injection was achieved in all limbs (n = 71). Relative risk of DIP joint puncture was 19 times higher (95% confidence interval 1.3-285.4, Pbursae from clinical cases. The lateral injection technique for the navicular bursa avoids penetration of the DDFT, although risk of synovial penetration must be considered when there is potential DIP joint or DFTS infection. © 2015 EVJ Ltd.

  18. Injection of the subacromial-subdeltoid bursa: blind or ultrasound-guided?

    NARCIS (Netherlands)

    Rutten, M.J.C.M.; Maresch, B.J.; Jager, G.J.; Waal Malefijt, M.C. de

    2007-01-01

    BACKGROUND: Blind injection of the subacromial-sub-deltoid bursa (SSB) for diagnostic purposes (Neer test) or therapeutic purposes (corticosteroid therapy) is frequently used. Poor response to previous blind injection or side effects may be due to a misplaced injection. It is assumed that ultrasound

  19. Host responses in the bursa of Fabricius of chickens infected with virulent Marek's disease virus

    Science.gov (United States)

    Host responses associated with very virulent Marek’s disease virus (MDV) infection in the bursa of Fabricius of chicken was investigated. The expression of MDV pp38 antigen and MDV gB transcripts were higher at 4 days post-infection (dpi) and then showed a declining trend. On the contrary, the expre...

  20. Arranged Bursa Folk Songs for Fourhands Piano and Their Practice in Music Education Departments

    Science.gov (United States)

    Demirci, Sirin Akbulut

    2016-01-01

    The article presents the results of a study carried out within the scope of a project entitled, "Arranged Bursa Folk Songs for Fourhands Piano Extended Piano Techniques and Teaching in Music Education Departments." It is number KUAP (E)-2014/28 of the Uludag University Scientific Research Projects Unit and was supported by the Bursa…

  1. Lipoma arborescens arising in the extra-articular bursa of the knee joint

    Science.gov (United States)

    Minami, Shinji; Miyake, Yusuke; Kinoshita, Hirofumi

    2016-01-01

    Lipoma arborescens arising in the extra-articular bursa of the knee joint is extremely rare. We describe an 11-year-old boy who complained of a gradual swelling mass of the lateral knee joint. Magnetic resonance imaging (MRI) showed a high signal intensity tumor on T1- and T2-weighted images with a thickened septa and nodular lesion that showed low signal intensity. The radiologist suggested the possible differential diagnosis of well-differentiated liposarcoma. At operation, the tumor was found under the iliotibial tract and was not in contact with the knee joint. Histopathologically, this lesion was diagnosed as lipoma arborescens arising in the extra-articular bursa of the knee joint. On MRI, the appearance of lipoma arborescens arising in the extra-articular bursa of the knee joint differed from that of conventional intra-articular lipoma arborescens. In this report, we describe a case of extra-articular lipoma arborescens of the knee joint bursa and discuss the diagnosis and etiology. PMID:27382924

  2. Case reports: ossified mass of the rotator cuff tendon in the subacromial bursa.

    Science.gov (United States)

    Matsumoto, Isshin; Ito, Yoichi; Tomo, Hiroyasu; Nakao, Yoshihiro; Takaoka, Kunio

    2005-08-01

    Unlike calcification, ossification is infrequent in the rotator cuff. We describe the clinical, radiographic, and pathologic findings in 64-year-old man with an ossified mass arising from a calcified portion of the rotator cuff tendon within the subacromial bursa. Mechanical stress and ischemic events are possible causes of cartilage formation followed by endochondral ossification, producing a mass causing outlet impingement.

  3. [Treatment of traumatic lesions of the bursa olecrani and chronic bursitis olecrani].

    Science.gov (United States)

    Saul, D; Dresing, K

    2017-06-01

    Complete olecranon bursectomy with debridement, protection of veins and nerves. Risk-adapted antibiotic therapy and early functional aftercare. Acute, traumatic laceration of the bursa olecrani, chronic therapy-resistant bursitis olecrani. For traumatic bursa injuries: general contraindications for anesthesia and surgery; chronic bursitis: initially not closable skin defect (plastic surgery required), hemodynamically instable patient (e.g. systemic inflammatory response syndrome [SIRS] or sepsis), pre-existing skin infection. Local anesthesia beyond the lesion, careful debridement, identification and removal of the entire bursa, excision of contaminated skin, lavage, drain insertion (Redon, Easy-flow, Penrose). Wound closure, elastic bandage, and splint. Elastic bandage for 2 days, followed by drain removal. Wound assessment, early functional aftercare without splint, antibiotic therapy in septic bursitis for 2 weeks, PRICE scheme. Removal of stitches after 10-12 days. Over 5 years, 138 cases of traumatic bursa lesion or chronic bursitis olecrani were treated in our clinic, 82 patients underwent surgery. Ten patients were treated with vacuum-assisted closure therapy and consecutive wound healing; fistulae occurred in two patients and in another two dehiscence developed. All of the defects could be closed without flaps.

  4. In vivo temperature measurement in the subacromial bursa during arthroscopic subacromial decompression.

    Science.gov (United States)

    Barker, Scott L; Johnstone, Alan J; Kumar, Kapil

    2012-06-01

    The purpose of the study was to evaluate whether use of a bi-polar radiofrequency (RF) ablation wand would cause excess heating, which may lead to collateral damage to the surrounding tissues during arthroscopic subacromial decompression. Cadaveric studies have shown that high temperatures can potentially be reached when using RF ablation wands in arthroscopic shoulder surgery. Only 1 other published study assesses these temperature rises in the clinical setting. Fifteen patients were recruited to participate in the study. A standard arthroscopic subacromial decompression was performed using continuous flow irrigation, with intermittent use of the RF ablation wand for soft tissue debridement. The temperature of the irrigation fluid within the subacromial bursa and the outflow fluid from the suction port of the wand were measured during the procedure using fiber-optic thermometers. The mean peak temperature recorded in the subacromial bursa was 32.0°C (29.3-43.1°C), with a mean rise from baseline of 9.8°C. The mean peak temperature recorded from the outflow fluid from the wand was 71.6°C (65.6-77.6°C), with a mean rise from baseline of 49.4°C. High temperatures were noted in the outflow fluid from the wand; however, this was not evident in the subacromial bursa itself. Use of room temperature inflow fluid, maintenance of flow through the bursa, and avoidance of prolonged uninterrupted use of the wand all appear to ensure that safe temperatures are maintained in the subacromial bursa not only in the laboratory but also in a clinical setting. Copyright © 2012 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Mosby, Inc. All rights reserved.

  5. Effects of Shepherd’s Purse (Capsella bursa pastoris (L. Medic. on the Chemical Composition of Lucerne (Medicago sativa L.

    Directory of Open Access Journals (Sweden)

    Tsvetanka Dimitrova

    2008-01-01

    Full Text Available A study was conducted in a pure stand of lucerne (variety Viktoria under natural weed infestation with shepherd’s purse (Capsella bursa pastoris (L. Medic. on a slightly leached chernozem soil under nonirrigated conditions in the experimental field of the Institute ofForage Crops – Pleven during the 2006-2007 period. The effect of shepherd’s purse Capsella bursa pastoris (L. Medic. on the chemical composition of lucerne Medicago sativa (L. was analyzed.Statistically significant (P<0.05 functional relations were found between the chemical characteristics and percentage of Capsella bursa pastoris (L. Medic. participation in the lucerne sward, and forage quality. These relations indicated a multiple practical relevance and a necessity to control Capsella bursa pastoris (L. Medic. in lucerne stands in order to decrease weed density and improve forage quality.

  6. Adhesion of the subacromial bursa may cause subacromial impingement in patients with rotator cuff tears: pressure measurements in 18 patients.

    Science.gov (United States)

    Machida, Akitoshi; Sugamoto, Kazuomi; Miyamoto, Takashi; Inui, Hiroaki; Watanabe, Tetsu; Yoshikawa, Hideki

    2004-02-01

    In order to determine whether adhesion of the subacromial bursa leads to impingement, we measured the subacromial contact pressures before and after release of adhesion of this bursa. 18 shoulders with cuff tears and adhesion of the subacromial bursa were evaluated in 8 male and 10 female patients, of mean age 62 (53-71) years and who had no particular limitation of shoulder motion. We recorded subacromial pressures using a very sensitive film inserted under the acromion during surgery. In passive scapular plane elevation (scaption) at 100 degrees, the mean subacromial contact pressure and area declined from 1.43 (SD 0.23) MPa before release to 1.14 (SD 0.35) MPa after release (p bursa increases impingement between the acromion and the insertion of rotator cuff tendons.

  7. Vacunacion contra la enfermedad infecciosa de la Bursa via aspersion y via agua de bebida en pollos de carne

    National Research Council Canada - National Science Library

    Castellanos C., Diana; Icochea D., Eliana; Guzman G., John; Reyna S., Pablo; Perales C., Rosa

    2012-01-01

    Se comparo dos vias de aplicacion de vacunas contra la Enfermedad Infecciosa de la Bursa en pollos de engorde, usando vacunas con cepas intermedia-intermedia en un programa de vacunacion a los 7 y 17 dias de edad...

  8. 30 Years Retrospective Review of Tuberculosis Cases in a Tuberculosis Dispensary in Bursa/Nilufer, Turkey (1985-2014)

    National Research Council Canada - National Science Library

    PALA, Kayıhan; GERÇEK, Harika; AYDIN TAŞ, Tuncay; ÇAKIR, Rukiye; ÖZGÜÇ, Sedef; YILDIZ, Timur

    2016-01-01

    Abstract Objective: The aim of this study was to evaluate tuberculosis control programmes of patients who applied to the Bursa Nilufer Tuberculosis Dispensary and by investigating the changes in the variables over 3 decades. Method...

  9. The role of tendon and subacromial bursa in rotator cuff tear pain: a clinical and histopathological study.

    Science.gov (United States)

    Chillemi, Claudio; Petrozza, Vincenzo; Franceschini, Vincenzo; Garro, Luca; Pacchiarotti, Alberto; Porta, Natale; Cirenza, Mirko; Salate Santone, Francesco; Castagna, Alessandro

    2016-12-01

    To evaluate a possible association of shoulder pain with the clinical features and the histopathological changes occurring in the ruptured tendon and subacromial bursa of patients with rotator cuff tear. One hundred and eighty patients were clinically evaluated with the constant score and the visual analogue pain scale. Radiographs and MRI were performed. The chronology of the rupture, the muscle fatty degeneration according to Goutallier's scale and the tear size were evaluated. For each patient, a biopsy of the supraspinatus tendon and subacromial bursa was performed during arthroscopic rotator cuff tear repair and the specimens were histopathologically analysed. Clinically, the shoulder was more painful in females, in the presence of a chronic cuff lesion and a low Goutallier's grade (P bursa were directly associated with pain (P bursa compared with those in the rotator cuff. Considering that the bursa plays also an essential role during the healing process, this "new" role of the subacromial bursa as pain generator has important repercussions in both pharmacological and surgical treatments of rotator cuff tears. IV.

  10. Expression of bioactive bone morphogenetic proteins in the subacromial bursa of patients with chronic degeneration of the rotator cuff.

    Science.gov (United States)

    Neuwirth, Jana; Fuhrmann, Renée A E; Veit, Amanda; Aurich, Matthias; Stonâns, Ilmars; Trommer, Tilo; Hortschansky, Peter; Chubinskaya, Susanna; Mollenhauer, Juergen A

    2006-01-01

    Degeneration of the rotator cuff is often associated with inflammation of the subacromial bursa and focal mineralization of the supraspinatus tendon. Portions of the supraspinatus tendon distant from the insertion site could transform into fibrous cartilage, causing rotator-cuff tears owing to mechanical instability. Indirect evidence is presented to link this pathology to ectopic production and secretion of bioactive bone morphogenetic proteins (BMPs) from sites within the subacromial bursa. Surgically removed specimens of subacromial bursa tissue from patients with chronic tears of the rotator cuff were analyzed by immunohistochemistry and reverse transcription-PCR. Bioactive BMP was detected in bursa extracts by a bioassay based on induction of alkaline phosphatase in the osteogenic/myogenic cell line C2C12. Topical and differential expression of BMP-2/4 and BMP-7 mRNA and protein was found in bursa tissue. The bioassay of C2C12 cells revealed amounts of active BMP high enough to induce osteogenic cell types, and blocking BMP with specific antibodies or soluble BMP receptors Alk-3 and Alk-6 abolished the inductive properties of the extract. Sufficient information was gathered to explain how ectopic expression of BMP might induce tissue transformation into ectopic bone/cartilage and, therefore, promote structural degeneration of the rotator cuff. Early surgical removal of the subacromial bursa might present an option to interrupt disease progression.

  11. Diagnostic endoscopy of the navicular bursa using a needle endoscope by direct or transthecal approach: A comparative cadaver study.

    Science.gov (United States)

    Mählmann, Kathrin; Koch, Christoph; Bodó, Gábor

    2015-10-01

    To compare the practicability, visualization of structures, and iatrogenic damage of direct and transthecal approaches to the navicular bursa for diagnostic needle endoscopy. Descriptive study. Equine cadaver forelimbs (n = 30). Direct and transthecal approaches for insertion of a needle endoscope into the navicular bursa were performed. Video recordings of endoscopic procedures were assessed to determine all structures visualized within the navicular bursa. Number of attempts to gain access to the navicular bursa and total time for insertion and examination were recorded. Distribution and severity of iatrogenic lesions were assessed and scored after dissection. There were no statistical differences for number of attempts or time needed for insertion and examination between direct and transthecal approaches. The direct approach offered significantly increased visibility of the ipsilateral abaxial and proximal margins of the navicular bone, and ipsilateral collateral sesamoidean ligament. Iatrogenic lesions were superficial and focal, regardless of approach taken, or whether a blunt or sharp trocar tip was used. The direct approach provided significantly better visualization of the ipsilateral structures within the navicular bursa compared to the transthecal approach. Needle endoscopy offers a reliable technique to evaluate the navicular bursa and may complement or replace other diagnostic modalities in horses with lameness localized to the navicular region. © Copyright 2015 by The American College of Veterinary Surgeons.

  12. Stability of Durum Wheat Genotypes in Some Agronomic Traits Under Bursa Ecological Conditions

    Directory of Open Access Journals (Sweden)

    Esra Aydoğan Çiftçi

    2017-11-01

    Full Text Available In the study it is aimed to determine the stabilities of some agronomic traits of 10 different durum wheats over the years in conditions of Bursa. Research was carried out in randomized complete block design with three replications between the years of 2008-2013. Averages of genotypes of agronomic characteristics, Eberhart and Russell’s regression coefficient and deviation from regression, Francis and Kannenberg’s coefficient of variation and environmental variance used as stability parameters. When the results of the study evaluated at the stability analysis, Amb × Çak-30 lines were determined to be stable in most of the agronomic traits. As for grain yield, which is of great importance for the producer, breeding lines of Amb × Çak -26 and Amb × Çak-30 were determined in good harmony at Bursa under different climatic conditions over five years.

  13. Calcium pyrophosphate dihydrate deposition in the trochanteric hip bursa presenting as acute hip pain.

    Science.gov (United States)

    Salar, Omer; Mushtaq, Fizza; Ahmed, Mushtaq

    2012-07-10

    Acute hip pain is a common reason for attendance to hospital. Immediate diagnoses include occult fractures, infectious and non-infectious inflammatory processes such as gout and pseudogout. Calcium pyrophosphate deposition disease (CPDD) is a rheumatological syndrome affecting articular cartilage and/or synovial fluid. It can occur as a clinical presentation (pseudogout) where calcium pyrophosphate dihydrate (CPPD) crystals are deposited within the joint space or radiographically, as chondrocalcinosis (CC), where CPPD crystals are deposited onto articular cartilages. Extraarticular manifestations of CPDD are rare. The authors report a case of CPPD deposition in the trochanteric bursa of a 35-year-old woman presenting as acute hip pain. The patient was treated successfully during arthroscopy with removal of the deposits and excision of the bursa. The patient remains well at 6 month follow-up.

  14. ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI UNDERPRICING SAHAM PADA PENAWARAN SAHAM PERDANA DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Reza Widhar Pahlevi

    2016-01-01

    Full Text Available Penelitian empiris ini dimaksudkan untuk mengetahui pengaruh Reputasi Underwriter, Reputasi Auditor, Persentase Saham yang ditawarkan ke Publik, Financial Leverage, Profitabilitas (ROA, Profitabilitas (NPM, Current Ratio, Ukuran Perusahaan, Umur Perusahaan, dan Jenis Industri terhadap Underpricing saham pada penawaran saham perdana di Bursa Efek Indonesia tahun 2000-2012. Berdasarkan hasil analisis data, pengujian secara parsial menunjukkan variabelvariabel Reputasi Underwriter, Reputasi Auditor, Persentase Saham yang ditawarkan ke Publik, dan Jenis Industri tidak mempunyai pengaruh yang signifikan terhadap Underpricing, Variabel Financial Leverage berpengaruh positif dan signifikan terhadap Underpricing. Sedangkan Variabel Profitabilitas (ROA, Profitabilitas (NPM, Current Ratio, Ukuran Perusahaan, dan Umur Perusahaan berpengaruh negatif dan signifikan terhadap Underpricing saham pada penawaran saham perdana di Bursa Efek Indonesia.Kata kunci : Initial Public Offering, Initial Return dan Underpricing

  15. Interleukin-1β stimulates stromal-derived factor-1α expression in human subacromial bursa.

    Science.gov (United States)

    Blaine, Theodore A; Cote, Mindy A; Proto, Al; Mulcahey, Mary; Lee, Francis Y; Bigliani, Louis U

    2011-11-01

    Chemokines produced by synoviocytes of the subacromial bursa are up-regulated in subacromial bursitis and rotator cuff disease. We hypothesized that SDF-1α production in bursal synoviocytes may be induced by local cytokines such as interleukin IL-1β and IL-6. Subacromial bursa specimens were obtained from patients undergoing shoulder surgery. Bursal specimens were stained with anti-human antibodies to IL-1, IL-6, and SDF-1α by immunohistochemistry and compared to normal and rheumatoid controls. Bursal cells were also isolated from specimens and cultured. Early passaged cells were then treated with cytokines (IL-1β and IL-6) and SDF-1α expression was measured by ELISA and RT-PCR. SDF-1α, IL-1β, and IL-6 were expressed at high levels in bursitis specimens from human subacromial bursa compared to normal controls. In cultured bursal synoviocytes, there was a dose-dependent increase in SDF-1α production in the supernatants of cells treated with IL-1β. SDF-1α mRNA expression was also increased in bursal cells treated with IL-1β. IL-6 caused a minimal but not statistically significant increase in SDF-1α expression. SDF-1α, IL-1β, and IL-6 are expressed in the inflamed human subacromial bursal tissues in patients with subacromial bursitis. In cultured bursal synoviocytes, SDF-1α gene expression and protein production are stimulated by IL-1β. IL-1β produced by bursal syvoviocytes and inflammatory cells in the human subacromial bursa is an important signal in the inflammatory response that occurs in subacromial bursitis and rotator cuff disease. Copyright © 2011 Orthopaedic Research Society.

  16. A Power Case Study for Monocrystalline and Polycrystalline Solar Panels in Bursa City, Turkey

    OpenAIRE

    Ayşegül Taşçıoğlu; Onur Taşkın; Ali Vardar

    2016-01-01

    It was intended to reveal the time dependent power generation under different loads for two different solar panels under the conditions of Bursa province in between August 19 and 25, 2014. The testing sets include solar panels, inverter, multimeter, accumulator, regulator, pyranometer, pyrheliometer, temperature sensor, and datalogger. The efficiency of monocrystalline and polycrystalline solar panels was calculated depending on the climatic data’s measurements. As the result of the study, th...

  17. The caudal bursa in the Heligmonellidae (Nematoda: Trichostrongylina. Characterization and hypothesis on its evolution

    Directory of Open Access Journals (Sweden)

    Durette-Desset M.C.

    2012-02-01

    Full Text Available The different patterns of the caudal bursa of the Heligmonellidae (Nematoda are redefined, taking into account the grouping of rays 2-6 and the sequence of origin of these rays from their common trunk. The type of symmetry of the caudal bursa is also redefined. The following patterns were observed and characterized: the basic patterns: types 2-3, 2-2-1, 1-3-1 and 1-4 and the intermediary patterns: type 2-3 tending to type 2-2-1, type 2-2-1 tending to type 1-3-1, type 1-3-1 tending to type 1-4 and type 2-2-1 tending to type 1-4. An evolutionary interpretation of the patterns is attempted and seems to follow the direction: 2-3 to 2-2-1 to 1-3-1 to 1-4. Seven atypical patterns are described. The caudal bursae were classified based on their symmetry: subsymmetrical, dissymmetrical and asymmetrical. Independently of the type of symmetry, the two latero-ventral lobes may have the same or different patterns. The type of symmetry, the ratio between the two latero-ventral lobes and a characteristic pattern were utilized to characterize the caudal bursae at the level of the genus and the subfamily. The combination of the right/left ratio and the type of symmetry gives heterogeneous results, with no real association between these characters. The most conspicuous asymmetries and dissymmetries were found among the Nippostrongylinae. The most frequent pattern in the Heligmonellidae is the basic type 2-2-1; types 1-3-1 and 1-4 are less frequent but are characteristic of several genera; type 1-4 is absent from the Heligmonellinae. Whatever the pattern, in the Heligmonellidae rays 4 and 5 are the last to diverge from the common trunk of rays 2-6.

  18. The caudal bursa in the Heligmonellidae (Nematoda: Trichostrongylina). Characterization and hypothesis on its evolution.

    Science.gov (United States)

    Durette-Desset, M C; Digiani, M C

    2012-02-01

    The different patterns of the caudal bursa of the Heligmonellidae (Nematoda) are redefined, taking into account the grouping of rays 2-6 and the sequence of origin of these rays from their common trunk. The type of symmetry of the caudal bursa is also redefined. The following patterns were observed and characterized: the basic patterns: types 2-3, 2-2-1, 1-3-1 and 1-4 and the intermediary patterns: type 2-3 tending to type 2-2-1, type 2-2-1 tending to type 1-3-1, type 1-3-1 tending to type 1-4 and type 2-2-1 tending to type 1-4. An evolutionary interpretation of the patterns is attempted and seems to follow the direction: 2-3 to 2-2-1 to 1-3-1 to 1-4. Seven atypical patterns are described. The caudal bursae were classified based on their symmetry: subsymmetrical, dissymmetrical and asymmetrical. Independently of the type of symmetry, the two latero-ventral lobes may have the same or different patterns. The type of symmetry, the ratio between the two latero-ventral lobes and a characteristic pattern were utilized to characterize the caudal bursae at the level of the genus and the subfamily. The combination of the right/left ratio and the type of symmetry gives heterogeneous results, with no real association between these characters. The most conspicuous asymmetries and dissymmetries were found among the Nippostrongylinae. The most frequent pattern in the Heligmonellidae is the basic type 2-2-1; types 1-3-1 and 1-4 are less frequent but are characteristic of several genera; type 1-4 is absent from the Heligmonellinae. Whatever the pattern, in the Heligmonellidae rays 4 and 5 are the last to diverge from the common trunk of rays 2-6.

  19. Proinflammatory cytokines and metalloproteases are expressed in the subacromial bursa in patients with rotator cuff disease.

    Science.gov (United States)

    Voloshin, Ilya; Gelinas, Jill; Maloney, Michael D; O'Keefe, Regis J; Bigliani, Louis U; Blaine, Theodore A

    2005-09-01

    The pathophysiology of subacromial impingement syndrome is poorly understood. We investigated the expression of inflammatory cytokines, metalloproteases, and the cyclooxygenases in the subacromial bursa in control patients and in patients with rotator cuff tear. Basic science evaluation. Eighteen patients undergoing shoulder surgery had a subacromial bursa biopsy examination. Patients were divided into 2 groups. Group I (study group) had 10 patients with a full-thickness rotator cuff tear (RCT). Group II (control group) had 8 patients. Seven of 8 underwent shoulder arthroscopy with anterior capsular reconstruction for instability; 1 of 8 underwent open reduction internal fixation for acute proximal humerus fracture. None of the patients in group II had any history of symptoms or signs consistent with subacromial impingement. H&E and immunohistochemical antibody (MMP-1, MMP-9, IL-1, IL-6, TNF-alpha, COX-1, and COX-2) stained specimens were examined by 2 blinded observers using a histologic scale (grade 0 = no staining to grade 4 = intense staining). Histologic evidence of inflammation was present in all patients with RCT (group I). No or mild inflammation was noted in group II. The average staining grade for inflammatory cytokines (IL-1, IL-6, TNF-alpha) and proteinases (MMP-1 and MMP-9) was significantly more pronounced in the RCT group (P bursa of patients with rotator cuff tear. These findings support the role of nonsteroidal anti-inflammatory drugs and corticosteroids in RCT treatment, and emphasize the importance of subacromial bursectomy to reduce inflammation in RCT surgery.

  20. Identification and characterization of a novel adenovirus in the cloacal bursa of gulls

    Energy Technology Data Exchange (ETDEWEB)

    Bodewes, R.; Bildt, M.W.G. van de; Schapendonk, C.M.E. [Department of Viroscience, Erasmus Medical Centre, Dr. Molewaterplein 50, 3015 GE Rotterdam (Netherlands); Leeuwen, M. van [Viroclinics Biosciences, Marconistraat 16, 3029 AK Rotterdam (Netherlands); Boheemen, S. van [Department of Viroscience, Erasmus Medical Centre, Dr. Molewaterplein 50, 3015 GE Rotterdam (Netherlands); Jong, A.A.W. de [Department of Pathology, Erasmus Medical Centre, Dr. Molewaterplein 50, 3015 GE Rotterdam (Netherlands); Osterhaus, A.D.M.E.; Smits, S.L. [Department of Viroscience, Erasmus Medical Centre, Dr. Molewaterplein 50, 3015 GE Rotterdam (Netherlands); Viroclinics Biosciences, Marconistraat 16, 3029 AK Rotterdam (Netherlands); Kuiken, T., E-mail: t.Kuiken@erasmusmc.nl [Department of Viroscience, Erasmus Medical Centre, Dr. Molewaterplein 50, 3015 GE Rotterdam (Netherlands)

    2013-05-25

    Several viruses of the family of Adenoviridae are associated with disease in birds. Here we report the detection of a novel adenovirus in the cloacal bursa of herring gulls (Larus argentatus) and lesser black-backed gulls (Larus fuscus) that were found dead in the Netherlands in 2001. Histopathological analysis of the cloacal bursa revealed cytomegaly and karyomegaly with basophilic intranuclear inclusions typical for adenovirus infection. The presence of an adenovirus was confirmed by electron microscopy. By random PCR in combination with deep sequencing, sequences were detected that had the best hit with known adenoviruses. Phylogenetic analysis of complete coding sequences of the hexon, penton and polymerase genes indicates that this novel virus, tentatively named Gull adenovirus, belongs to the genus Aviadenovirus. The present study demonstrates that birds of the Laridae family are infected by family-specific adenoviruses that differ from known adenoviruses in other bird species. - Highlights: ► Lesions typical for adenovirus infection detected in cloacal bursa of dead gulls. ► Confirmation of adenovirus infection by electron microscopy and deep sequencing. ► Sequence analysis indicates that it is a novel adenovirus in the genus Aviadenovirus. ► The novel (Gull) adenovirus was detected in multiple organs of two species of gulls.

  1. Subacromial Bursa Injection of Hyaluronate with Steroid in Patients with Peri-articular Shoulder Disorders

    Science.gov (United States)

    Byun, Seung Deuk; Choi, Won Duck; Lee, Zee Ihn

    2011-01-01

    Objective To investigate the additive effect of sono-guided subacromial bursa injection of hyaluronate with steroid in patients with peri-articular shoulder disorders. Method This prospective randomized controlled trial involved 26 patients who had shoulder pain. Group A, consisting of 13 patients, was treated with a sono-guided subacromial bursa injection containing a mixture of 0.5% lidocaine (5 ml) and triamcinolone 40 mg (1 ml), followed by injection with sodium hyaluronate (2 ml) once a week for 3 weeks. The other 13 patients (Group B) were treated with a sono-guided subacromial bursa injection containing a mixture of 0.5% lidocaine (5 ml) and triamcinolone 40 mg (1 ml) once a week for 3 weeks. The effects were assessed using a visual analogue scale (VAS) of shoulder pain, active range of motion (AROM), shoulder function assessment scale (SFA), shoulder disability questionnaire (SDQ) at study entry and every week from first injection until 4 weeks after the 1st injection (= 2 weeks after 3rd injection). Results (1) Demographic features and all parameters measured before injection did not show a significant difference between the 2 groups. (2) Statistically significant improvements were shown in VAS, SFA, SDQ during the 1st, 2nd, and 4th week after the first injection in both groups (pbursa injection of hyaluronate with steroid in patients with peri-articular shoulder disorders has additive effects on functional improvement of the affected shoulder, including the AROM of internal rotation. PMID:22506189

  2. Finding the lost segment of the North Anatolian Fault in the Bursa Basin, Turkey

    Science.gov (United States)

    Kutoglu, S. H.; Deguchi, T.; Gundogdu, O.; Seker, D. Z.; Kuscu, S.

    2011-12-01

    After the 1999 Golcuk Mw=7.4, the seismic stress of the North Anatolian Fault has been transferred onto the segments in the Marmara Sea. The NAF is separated to three branches around the Marmara region; one branch runs into the Marmara Sea from the Yalova-Cinarcik location in the north, the second branch runs into the Marmara Sea from the Gemlik location in the south, and the last one goes toward the Bursa basin from the Sakarya-Pamukova location in the lower south. Some researchers consider that the south branch, which experienced the last major earthquake in the year 1064, poses a danger as much as the north branch.For that reason, this study has been conducted for monitoring the fault activities around the Bursa basin. In this respect, the four Palsar data having the best baseline condition have been obtained between the years 2007-2010. The processing of these data have been resulted in significant deformation interferograms for the data pairs of 31st Oct 2007-8th May 2010 and 31st Jan. 2008-24th Dec. 2010. There are seen deformation anomalies in the Bursa basin along 33 km long in E-W direction and 4.5 km long in N-S direction. The shape of the deformation fringes points out that there is a right lateral strike slip fault line passing through the Bursa basin. The geomorphologic characteristics in the region make us think this fault line may connect to the Sakarya-Geyve branch of the North Anatolian Fault system. The maximum amount of the deformation around the fault line has been determined 18 cm in three years. This amount is too much in comparison to 2.2 cm/yr slip rate of the NAF. As the deformation anomalies are investigated in detail a contraction draws attention, overlapping with a right lateral strike slip motion. Consequently, it can precociously be sad that there exits an uplifting combining with the lateral motion. In addition, significant deformation anomalies have been detected on the Gemlik location where the Iznik fault segment reaches the

  3. Mükelleflerin Yerel Vergi Algıları Üzerine Bir Analiz: Bursa Örneği(An Analysis of Local Tax Perceptions of Tax Payers: A Case Study in Bursa

    Directory of Open Access Journals (Sweden)

    R. Kutlu KORLU

    2016-12-01

    Full Text Available Awareness level of citizens about local taxes seem to affect their behaviours in this regard, that is to say their tax compliance. In this study, Bursa citizens’ perceptions on local taxes were measured through using a questionnaire study after providing theoretical information about tax compliance. In conclusion, this study revealed that Bursa citizens had an average level of knowledge on local taxes; that tax payment culture should be improved; that tax amnesty harms this culture; and that there are significant differences among the groups with regard to answers given in statements about the fact that taxpayment is a sacred duty

  4. Outcomes after fluoroscopy-guided iliopsoas bursa injection for suspected iliopsoas tendinopathy.

    Science.gov (United States)

    Agten, Christoph A; Rosskopf, Andrea B; Zingg, Patrick O; Peterson, Cynthia K; Pfirrmann, Christian W A

    2015-03-01

    To report patient outcomes up to 1 month after fluoroscopy-guided iliopsoas bursa injection for suspected iliopsoas tendinopathy. Thirty-nine consecutive patients (mean age 45 years; range 15-77) who underwent fluoroscopy-guided therapeutic iliopsoas bursa injection using an anterolateral approach and who returned an outcomes questionnaire were prospectively included. The Patients' Global Impression of Change (PGIC) scale was recorded 1 day, 1 week, and 1 month after the injection (primary outcome measure). Patients' subjective pain level data were collected prior to the injection (baseline) using a numeric rating scale (NRS; 0 = no pain; 10 = maximum pain). NRS scores were completed 15 min, 1 day, 1 week, and 1 month post-injection and compared to baseline. Forty-nine per cent of patients reported clinically relevant 'improvement' (PGIC) 1 month post-injection. Mean NRS score prior to injection was 5.9 ± 2.1. Mean NRS scores after 15 min (3.6 ± 2.7), 1 day (4.4 ± 2.7), 1 week (3.4 ± 1.9), and 1 month (3.5 ± 2.5) were statistically significantly lower (p ≤ 0.001) compared to baseline. Reduction of NRS ≥50 % after 15 min was achieved in 49 % (56 % of those unimproved at 1 month). Fluoroscopy-guided iliopsoas bursa injection leads to a relevant 'improvement' at 1 month or significant pain reduction after 15 min in most patients.

  5. Perspective Research Progress in Cold Responses of Capsella bursa-pastoris

    Science.gov (United States)

    Noman, Ali; Kanwal, Hina; Khalid, Noreen; Sanaullah, Tayyaba; Tufail, Aasma; Masood, Atifa; Sabir, Sabeeh-ur-Rasool; Aqeel, Muhammad; He, Shuilin

    2017-01-01

    Plants respond to cold stress by modulating biochemical pathways and array of molecular events. Plant morphology is also affected by the onset of cold conditions culminating at repression in growth as well as yield reduction. As a preventive measure, cascades of complex signal transduction pathways are employed that permit plants to endure freezing or chilling periods. The signaling pathways and related events are regulated by the plant hormonal activity. Recent investigations have provided a prospective understanding about plant response to cold stress by means of developmental pathways e.g., moderate growth involved in cold tolerance. Cold acclimation assays and bioinformatics analyses have revealed the role of potential transcription factors and expression of genes like CBF, COR in response to low temperature stress. Capsella bursa-pastoris is a considerable model plant system for evolutionary and developmental studies. On different occasions it has been proved that C. bursa-pastoris is more capable of tolerating cold than A. thaliana. But, the mechanism for enhanced low or freezing temperature tolerance is still not clear and demands intensive research. Additionally, identification and validation of cold responsive genes in this candidate plant species is imperative for plant stress physiology and molecular breeding studies to improve cold tolerance in crops. We have analyzed the role of different genes and hormones in regulating plant cold resistance with special reference to C. bursa-pastoris. Review of collected data displays potential ability of Capsella as model plant for improvement in cold stress regulation. Information is summarized on cold stress signaling by hormonal control which highlights the substantial achievements and designate gaps that still happen in our understanding. PMID:28855910

  6. Perspective Research Progress in Cold Responses of Capsella bursa-pastoris

    Directory of Open Access Journals (Sweden)

    Ali Noman

    2017-08-01

    Full Text Available Plants respond to cold stress by modulating biochemical pathways and array of molecular events. Plant morphology is also affected by the onset of cold conditions culminating at repression in growth as well as yield reduction. As a preventive measure, cascades of complex signal transduction pathways are employed that permit plants to endure freezing or chilling periods. The signaling pathways and related events are regulated by the plant hormonal activity. Recent investigations have provided a prospective understanding about plant response to cold stress by means of developmental pathways e.g., moderate growth involved in cold tolerance. Cold acclimation assays and bioinformatics analyses have revealed the role of potential transcription factors and expression of genes like CBF, COR in response to low temperature stress. Capsella bursa-pastoris is a considerable model plant system for evolutionary and developmental studies. On different occasions it has been proved that C. bursa-pastoris is more capable of tolerating cold than A. thaliana. But, the mechanism for enhanced low or freezing temperature tolerance is still not clear and demands intensive research. Additionally, identification and validation of cold responsive genes in this candidate plant species is imperative for plant stress physiology and molecular breeding studies to improve cold tolerance in crops. We have analyzed the role of different genes and hormones in regulating plant cold resistance with special reference to C. bursa-pastoris. Review of collected data displays potential ability of Capsella as model plant for improvement in cold stress regulation. Information is summarized on cold stress signaling by hormonal control which highlights the substantial achievements and designate gaps that still happen in our understanding.

  7. Antibodies, immunoglobulin genes and the bursa of Fabricius in chicken B cell development.

    Science.gov (United States)

    Ratcliffe, Michael J H

    2006-01-01

    The bursa of Fabricius is critical for the normal development of B lymphocytes in birds. It is productively colonized during embryonic life by a limited number of B cell precursors that have undergone the immunoglobulin gene rearrangements required for expression of cell surface immunoglobulin. Immunoglobulin gene rearrangement occurs in the absence of terminal deoxynucleotidyl transferase and generates minimal antibody diversity. In addition, observations that immunoglobulin heavy and light chain variable gene rearrangement occur at the same time and that allelic exclusion of immunoglobulin expression is regulated at the level of variable region gene rearrangement provide a striking contrast to rodent and primate models of immunoglobulin gene assembly. Following productive colonization of the bursa, developing B cells undergo rapid proliferation and the immunoglobulin V region genes that generate the specificity of the B cell surface immunoglobulin receptor undergo diversification. Immunoglobulin diversity in birds is generated by somatic gene conversion events in which sequences derived from upstream families of pseudogenes replace homologous sequences in unique and functionally rearranged immunoglobulin heavy and light chain variable region genes. This mechanism is distinct from and much more efficient than mechanisms of antibody diversification seen in rodents and primates. While the bursal microenvironment is not required for immunoglobulin gene rearrangement and expression, it is essential for the generation of antibody diversity by gene conversion. Following hatch, gut derived antigens are taken up by the bursa. While bursal development prior to hatch occurs in the absence of exogenous antigen, chicken B cell development after hatch may therefore be influenced by the presence of environmental antigen. This review focuses on the differences between B cell development in the chicken as compared to rodent and primate models.

  8. The climate and bioclimate of Bursa (Turkey) from the perspective of tourism

    Science.gov (United States)

    Çalışkan, Onur; Çiçek, Ihsan; Matzarakis, Andreas

    2012-02-01

    Climate is an important resource for tourism and an equally important element that needs to be included in tourism promotions. This study reveals Bursa's bioclimatological conditions. These conditions were identified by using physiologically equivalent temperature and a Climate-Tourism-Information-Scheme over 10-day periods and analyzing the mean thermal perception values that emerged. Evaluating bioclimatic conditions and meteorological parameters such as air temperature, duration of sunshine, number of wet days, amount of precipitation, and wind from the perspective of tourism will help people choose the best holiday times depending on their individual needs and circumstances.

  9. Static vs stochastic optimization: A case study of FTSE Bursa Malaysia sectorial indices

    Science.gov (United States)

    Mamat, Nur Jumaadzan Zaleha; Jaaman, Saiful Hafizah; Ahmad, Rokiah@Rozita

    2014-06-01

    Traditional portfolio optimization methods in the likes of Markowitz' mean-variance model and semi-variance model utilize static expected return and volatility risk from historical data to generate an optimal portfolio. The optimal portfolio may not truly be optimal in reality due to the fact that maximum and minimum values from the data may largely influence the expected return and volatility risk values. This paper considers distributions of assets' return and volatility risk to determine a more realistic optimized portfolio. For illustration purposes, the sectorial indices data in FTSE Bursa Malaysia is employed. The results show that stochastic optimization provides more stable information ratio.

  10. The effects of scapulothoracic bursa injections in patients with scapular pain: a pilot study.

    Science.gov (United States)

    Chang, Won Hyuk; Im, Sang Hee; Ryu, Jeong Ah; Lee, Sang Chul; Kim, Ji Sung

    2009-02-01

    To assess the effects of steroid plus hyaluronate injections for scapulothoracic bursitis in patients with scapular pain. Prospective open-label unicenter trial with a 3-month follow-up. University rehabilitation hospital. Twenty-two cases of suspected scapulothoracic bursitis. Injections into scapulothoracic bursa were performed with steroid plus hyaluronate. Injections were administered once a week for 3 weeks. Visual analog scale (VAS), Rubin scale, adverse events, and injection-associated complications. Mean outcome scores at 3-month follow-up visits showed significant improvements versus baseline (mean VAS increased from 7.8 to 2.2) (Pbursa provide an effective means of treating patients with scapulothoracic bursitis.

  11. The dynamic relationship between Bursa Malaysia composite index and macroeconomic variables

    Science.gov (United States)

    Ismail, Mohd Tahir; Rose, Farid Zamani Che; Rahman, Rosmanjawati Abd.

    2017-08-01

    This study investigates and analyzes the long run and short run relationships between Bursa Malaysia Composite index (KLCI) and nine macroeconomic variables in a VAR/VECM framework. After regression analysis seven out the nine macroeconomic variables are chosen for further analysis. The use of Johansen-Juselius Cointegration and Vector Error Correction Model (VECM) technique indicate that there are long run relationships between the seven macroeconomic variables and KLCI. Meanwhile, Granger causality test shows that bidirectional relationship between KLCI and oil price. Furthermore, after 12 months the shock on KLCI are explained by innovations of the seven macroeconomic variables. This indicate the close relationship between macroeconomic variables and KLCI.

  12. MANAJEMEN LABA (EARNING MANAGEMENT DAN PEMILIHAN METODE AKUNTANSI PADA SAAT IPO (STUDI PADA BURSA EFEK JAKARTA

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    Handriyono Handriyono

    2016-01-01

    Full Text Available Ada banyak faktor yang mempengaruhi perilaku manajer untuk mengendalikan tingkat keuntungan suatu perusahaan dan informasi keuangan. Studi empirik membuktikan ada 5 faktor yang berhubungan dengan manajemen laba yaitu ukuran perusahaan, tingkat pertumbuhan perusahaan, financial leverage, proporsi saham pemilik perusahaan, penjamin emisi. Penelitian ini menggunakan 34 perusahaan industri sebagai sampel penelitian yang go publik antara 1995 sampai dengan 1997 di Bursa Efek Jakarta. Hasil analisis dengan menggunakan Total Accrual Multivariate yaitu Ordinary Least Square model, menunjukkan bahwa hanya ukuran perusahaan yang mempunyai hubungan yang signifikan pada perusahaan yang go publik, dan variabel yang lain tidak signifikan.

  13. Static vs stochastic optimization: A case study of FTSE Bursa Malaysia sectorial indices

    Energy Technology Data Exchange (ETDEWEB)

    Mamat, Nur Jumaadzan Zaleha; Jaaman, Saiful Hafizah; Ahmad, Rokiah Rozita [School of Mathematical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor (Malaysia)

    2014-06-19

    Traditional portfolio optimization methods in the likes of Markowitz' mean-variance model and semi-variance model utilize static expected return and volatility risk from historical data to generate an optimal portfolio. The optimal portfolio may not truly be optimal in reality due to the fact that maximum and minimum values from the data may largely influence the expected return and volatility risk values. This paper considers distributions of assets' return and volatility risk to determine a more realistic optimized portfolio. For illustration purposes, the sectorial indices data in FTSE Bursa Malaysia is employed. The results show that stochastic optimization provides more stable information ratio.

  14. Fractional Ornstein-Uhlenbeck for index prices of FTSE Bursa Malaysia KLCI

    Science.gov (United States)

    Chen, Kho Chia; Bahar, Arifah; Ting, Chee-Ming

    2014-07-01

    This paper studies the Ornstein-Uhlenbeck model that incorporates long memory stochastic volatility which is known as fractional Ornstein-Uhlenbeck model. The determination of the existence of long range dependence of the index prices of FTSE Bursa Malaysia KLCI is measured by the Hurst exponent. The empirical distribution of unobserved volatility is estimated using the particle filtering method. The performance between fractional Ornstein -Uhlenbeck and standard Ornstein -Uhlenbeck process had been compared. The mean square errors of the fractional Ornstein-Uhlenbeck model indicated that the model describes index prices better than the standard Ornstein-Uhlenbeck process.

  15. Synovial osteochondromatosis of the suprapatellar bursa with an imperforate suprapatellar plica.

    Science.gov (United States)

    Boya, Hakan; Pinar, Halit; Ozcan, Ozal

    2002-04-01

    Synovial osteochondromatosis is a rare disease characterized by cartilaginous and osseous metaplasia of the joint synovium. While it may affect practically any synovial joint, the knee is most often affected. An imperforate suprapatellar plica is also a rare finding in the knee. We report an exceptionally rare case of synovial osteochondromatosis of the knee characterized by isolated multiple loose bodies in the suprapatellar bursa caused by imperforate suprapatellar plica in a 52-year-old woman. The case was successfully treated by arthroscopic surgery. A worse-case scenario and possible diagnostic and therapeutic challenges are discussed.

  16. Stochastic differential equation (SDE) model of opening gold share price of bursa saham malaysia

    Science.gov (United States)

    Hussin, F. N.; Rahman, H. A.; Bahar, A.

    2017-09-01

    Black and Scholes option pricing model is one of the most recognized stochastic differential equation model in mathematical finance. Two parameter estimation methods have been utilized for the Geometric Brownian model (GBM); historical and discrete method. The historical method is a statistical method which uses the property of independence and normality logarithmic return, giving out the simplest parameter estimation. Meanwhile, discrete method considers the function of density of transition from the process of diffusion normal log which has been derived from maximum likelihood method. These two methods are used to find the parameter estimates samples of Malaysians Gold Share Price data such as: Financial Times and Stock Exchange (FTSE) Bursa Malaysia Emas, and Financial Times and Stock Exchange (FTSE) Bursa Malaysia Emas Shariah. Modelling of gold share price is essential since fluctuation of gold affects worldwide economy nowadays, including Malaysia. It is found that discrete method gives the best parameter estimates than historical method due to the smallest Root Mean Square Error (RMSE) value.

  17. A Power Case Study for Monocrystalline and Polycrystalline Solar Panels in Bursa City, Turkey

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    Ayşegül Taşçıoğlu

    2016-01-01

    Full Text Available It was intended to reveal the time dependent power generation under different loads for two different solar panels under the conditions of Bursa province in between August 19 and 25, 2014. The testing sets include solar panels, inverter, multimeter, accumulator, regulator, pyranometer, pyrheliometer, temperature sensor, and datalogger. The efficiency of monocrystalline and polycrystalline solar panels was calculated depending on the climatic data’s measurements. As the result of the study, the average performances of monocrystalline and polycrystalline panels are 42.06 and 39.80 Wh, respectively. It was seen that 87.14 W instantaneous power could be obtained from monocrystalline solar panel and that 80.17 W instantaneous power could be obtained from polycrystalline solar panel under maximum total radiation (1001.13 W/m2. Within this frame, it was determined that monocrystalline solar panel is able to operate more efficiently under the conditions of Bursa compared to polycrystalline solar panel. When the multivariate correlations coefficients were examined statistically, a significant relationship in positive direction was detected between total and direct radiation and ambient temperature on energy generation from monocrystalline and polycrystalline panel.

  18. Fenómeno de vacío en la bursa iliopsoas como posible fuente de error diagnóstico radiológico Vacuum phenomena in iliopsoas bursa: a possible pitfall at CT and MR imaging

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    Esteban Mayayo Sinués

    2009-03-01

    Full Text Available El fenómeno de vacío es una alteración conocida en las articulaciones osteoartríticas. En ocasiones puede verse gas en las bursas adyacentes a las articulaciones debido a la existencia de una comunicación con la articulación. Presentamos un caso de fenómeno de vacío en la bursa iliopsoas en asociación a una cadera osteoartrítica sobre la base de una displasia acetabular en una mujer de 48 años que acudió a nuestra consulta con sospecha inicial de absceso de iliopsoas.Vacuum phenomena is a well-known alteration in osteoarthritis. It´s possible to see gas in bursas around osteoarthritic joints due to comunication between them. We describe an unusual case of vacuum phenomena arising within an enlarged iliopsoas bursa in association with mildly osteoarthritic and dysplastic hip in a 48-year-old woman who underwent radiologic study in our institution with an initial suspiction of iliopsoas abscess.

  19. [Isolated synovial chondromatosis of the subacromial bursa: report of a new case and review of the literature].

    Science.gov (United States)

    Bouhaouala, M H; Saïd, W; Salah, M Haj; Bouaziz, N; Mourali, S; Chaabane, S

    2006-01-01

    Synovial chondromatosis is a rare metaplasia of the synovium of unknown etiology that may involve occasionally the subacromial bursa. We report a new case diagnosed by ultrasound in a 30-year-old man and we present pathogenetic, diagnostic and therapeutic features of this disease with a literature review.

  20. Normative size of the osseous part of calcaneal bursa and its comparison with other calcaneal articular areas.

    Science.gov (United States)

    Mahato, Niladri Kumar

    2017-08-01

    The retro-calcaneal bursa presents a synovial and a non-synovial osseous part of variable dimensions. Studies objectively measuring the variability of the size of this osseous bursal surface cannot be found in literature. The objective of this study was to investigate (i) the dimension variability of the bony part of the bursa and (ii) the relationship of this surface to other articulating areas of the calcaneus. A digital planimeter was used to measure the bursae (n=86) and other articular surface areas of the calcaneus and statistically compared with ANOVA and correlation estimations. The osseous area measured 1.12 (±0.55) cm2, with only the superior articulating area demonstrating a weak correlation to this osseous surface. The osseous area presents a weak correlation with the axial articulating area of the calcaneus. Information on the size of the bony bursa may help safe excision of retrocalcaneal exostoses and in Achille's tendon repair around the posterior tuberosity. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Rapid destruction of the hip joint associated with enlarged iliopsoas bursa in a patient with refractory rheumatoid arthritis.

    Science.gov (United States)

    Yoshioka, Taro; Tachihara, Akitoshi; Koyama, Tairo; Iwakawa, Kayo; Sakane, Manabu; Nakamura, Hiroshi

    2008-08-01

    A case of refractory rheumatoid arthritis with a rapid destruction of the hip joint and an enlarged iliopsoas bursa is presented. Rapidly destructive coxarthrosis, chondrocalcinosis, suppurative arthritis, and pigmented villonodular synovitis were the differential diagnoses. Radiological examination showed that rheumatoid arthritis was most likely diagnosis. The patient was treated with total hip arthroplasty and etanercept, with good results.

  2. Evaluation of diffusion of triamcinolone acetonide from the distal interphalangeal joint into the navicular bursa in horses.

    Science.gov (United States)

    Boyce, Mary; Malone, Erin D; Anderson, Lorraine B; Park, Seijin; Godden, Sandra M; Jenner, Florien; Trumble, Troy N

    2010-02-01

    To determine whether triamcinolone acetonide diffuses from the distal interphalangeal joint (DIPJ) to the navicular bursa, diffusion is direct or systemic, and addition of sodium hyaluronan has an effect on diffusion in horses. 11 adult horses without forelimb lameness. 1 randomly chosen forelimb DIPJ of each horse received an injection of 10 mg of triamcinolone acetonide plus 20 mg of sodium hyaluronan (group 1), and the contralateral forelimb DIPJ received an injection of 10 mg of triamcinolone acetonide plus 2 mL of lactated Ringer's solution (group 2). Synovial fluid samples were taken from both forelimb navicular bursae and 1 hind limb navicular bursa (systemic control group) at 6 hours. Triamcinolone acetonide concentrations in synovial fluid were quantified by use of high-performance liquid chromatography plus tandem mass spectrometry. Data were logarithmically transformed, and contrast analysis was performed on the 3 groups. Triamcinolone acetonide was detected in navicular bursal samples in all groups. Groups 1 and 2 had significantly greater concentrations of triamcinolone acetonide than the systemic control group. There was no significant difference between groups 1 and 2. Triamcinolone acetonide diffused directly from the DIPJ into the navicular bursa in clinically normal horses, and diffusion was not affected by addition of hyaluronan. Injection into the DIPJ with triamcinolone acetonide or a triamcinolone acetonide-hyaluronan combination can potentially be used for treatment of navicular syndrome, but further studies are needed to determine whether triamcinolone acetonide diffuses similarly in horses with navicular syndrome.

  3. Effect of environmental antigens on the Ig diversification and the selection of productive V-J joints in the bursa.

    Science.gov (United States)

    Arakawa, Hiroshi; Kuma, Kei-ichi; Yasuda, Masahiro; Ekino, Shigeo; Shimizu, Akira; Yamagishi, Hideo

    2002-07-15

    In chickens, a single set of unique functional segments of both Ig H and L chain genes is rearranged during early embryogenesis to generate a pool of B cell progenitors that will be diversified in the bursa by gene conversion, forming the preimmune repertoire. After hatching, bursal cells are exposed to environmental Ags in the bursal lumen. We prepared B cells from each single bursal follicle and used PCR-directed Ig L chain gene analysis to study the differentiation of B cells and the effect of antigenic stimulation from the bursal lumen on the neonatal chicken B cell repertoire formation. Selective amplification of B cell clones with a productive V-J joint was observed during the late embryonic stage, possibly by the interaction with ligands expressed on the bursal stroma and further accelerated in the neonatal chicken. Administration of the artificial Ags into the bursal lumen before the isolation of bursa by bursal duct ligation in the embryo caused a significant increase in lymphocytes with a productive V-J joint in the neonatal chicken bursa compared with the isolated bursa. Intra- and interclonal diversity of a complementarity-determining region measured by an evolutionary distance increased during bursal development. Clonal diversification did not require stimulation by artificial Ags from the bursal lumen. Thus, the preimmune repertoire in the bursa is generated by gene conversion during Ag-independent B cell proliferation, and antigenic stimulation from the bursal epithelium to bursal B cells plays roles in the selection of clones with a productive V-J joint.

  4. Synovial chondromatosis of the subacromial bursa causing a bursal-sided rotator cuff tear.

    Science.gov (United States)

    Neumann, Julie A; Garrigues, Grant E

    2015-01-01

    Synovial chondromatosis is an uncommon condition, and involvement of the shoulder is even more rare. We report on a 39-year-old female who presented with symptoms, radiographic features, and intraoperative findings consistent with multiple subacromial loose bodies resulting in a partial-thickness, bursal-sided rotator cuff tear of the supraspinatus muscle. She was treated with an arthroscopic removal of loose bodies, complete excision of the subacromial/subdeltoid bursa, acromioplasty, and rotator cuff repair. To our knowledge, this is the first report of arthroscopic treatment for a bursal-sided, partial-thickness rotator cuff tear treated with greater than two-year clinical and radiographic follow-up. We utilized shoulder scores, preoperative and postoperative range of motion, and imaging to assess the results of treatment and surveillance for recurrence in our patient after two-year follow-up.

  5. Black-Scholes finite difference modeling in forecasting of call warrant prices in Bursa Malaysia

    Science.gov (United States)

    Mansor, Nur Jariah; Jaffar, Maheran Mohd

    2014-07-01

    Call warrant is a type of structured warrant in Bursa Malaysia. It gives the holder the right to buy the underlying share at a specified price within a limited period of time. The issuer of the structured warrants usually uses European style to exercise the call warrant on the maturity date. Warrant is very similar to an option. Usually, practitioners of the financial field use Black-Scholes model to value the option. The Black-Scholes equation is hard to solve analytically. Therefore the finite difference approach is applied to approximate the value of the call warrant prices. The central in time and central in space scheme is produced to approximate the value of the call warrant prices. It allows the warrant holder to forecast the value of the call warrant prices before the expiry date.

  6. A Rare Case of Deep Digital Flexor Tendinopathy following Centesis of the Navicular Bursa

    Science.gov (United States)

    Froydenlund, Tim J.; Meehan, Lucinda J.; Morrison, Linda R.; Labens, Raphael

    2017-01-01

    Navicular bursa (NB) centesis is a common diagnostic and therapeutic procedure in equine practice. This case report documents the clinical, diagnostic imaging and histological findings in a horse with a suspected iatrogenic deep digital flexor tendon (DDFT) injury following centesis of the NB via a modified distal plantar approach (placement of two needles in a weight bearing position). Although it cannot be proven with absolute certainty, the authors believe that this is the first reported case where NB centesis is the likely cause of a DDFT lesion, and with magnetic resonance imaging performed both pre- and post-centesis. With this potential, though rare, complication of the procedure, alternative tendon sparing injection techniques should be considered prior to NB centesis in certain cases. PMID:29085826

  7. Osteochondroma of the scapula associated with winging and large bursa formation.

    Science.gov (United States)

    Mohsen, Mahmoodi Seyed; Moosa, Nooruddin K; Kumar, Pradeep

    2006-01-01

    To report a case of scapular osteochondroma associated with pain and winging that is rarely reported in the medical literature. A 19-year-old male presented with pain and winging of the right scapula. CT scan revealed an osteochondroma of the medial border of the scapula with a large bursa between the chest wall and the tumour. Excision of the tumour relieved the symptoms. Pathological study showed osteochondroma of the scapula. In a follow-up 1 year later he was free of pain with no clinical or radiological sign of recurrence. A case of scapular osteochondroma associated with pain and winging treated by excision and follow-up showed no sign of clinical or radiological recurrence.

  8. PERANCANGAN PREDIKSI FINANCIAL DISTRESS PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Rina Sri Wulandari

    2016-12-01

    Full Text Available Krisis ekonomi global menyebabkan banyak perusahaan terutama perusahaan manufaktur mengalami financial distress. Financial distress adalah keadaan dimana perusahaan dalam kondisi kesulitan keuangan sebelum mengalami kebangkrutan. Melakukan prediksi terhadap kondisi keuangan penting dilakukan oleh manajer, auditor serta investor untuk melakukan kebijakan pengambilan keputusan. Semakin akurat prediksi yang dilakukan, maka resiko yang akan ditanggung semakin kecil baik oleh perusahaan maupun oleh investor. Oleh karena itu, penelitian ini bertujuan untuk merancang model prediksi financial distress perusahaan manufaktur yang terdaftar di bursa efek Indonesia. Penelitian ini menggunakan metode Data Envelopment Analysis (DEA. Metode DEA digunakan untuk mengukur efisiensi perusahaan. Perusahaan yang dinyatakan tidak efisien menunjukkan bahwa perusahaan tersebut terancam mengalami kebangkrutan. Rasio-rasio laporan keuangan perusahaan digunakan sebagai data yang akan diolah dengan menggunakan metode DEA.

  9. Phenolic Glycosides from Capsella bursa-pastoris (L. Medik and Their Anti-Inflammatory Activity

    Directory of Open Access Journals (Sweden)

    Joon Min Cha

    2017-06-01

    Full Text Available A new sesquilignan glycoside 1, together with seven known phenolic glycosides 2–8 were isolated from the aerial parts of Capsella bursa-pastoris. The chemical structure of the new compound 1 was elucidated by extensive nuclear magnetic resonance (NMR data (1H- and 13C-NMR, 1H-1H correlation spectroscopy (1H-1H COSY, heteronuclear single-quantum correlation (HSQC, heteronuclear multiple bond correlation (HMBC, and nuclear overhauser effect spectroscopy (NOESY and HR-FABMS analysis. The anti-inflammatory effects of 1–8 were evaluated in lipopolysaccharide (LPS-stimulated murine microglia BV-2 cells. Compounds 4 and 7 exhibited moderate inhibitory effects on nitric oxide production in LPS-activated BV-2 cells, with IC50 values of 17.80 and 27.91 µM, respectively.

  10. Tinjauan Rencana Adopsi IAS 41 pada Perusahaan Agrikultur di Bursa Efek Indonesia

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    Heny Kurniawati

    2013-05-01

    Full Text Available The purpose of this study is to analyze the adoption plan of IAS 41 Agriculture as a part of IFRS Convergence in Indonesia by investigating the characteristics of biological assets and agriculture produce in public listed companies in Bursa Efek Indonesia (BEI. The methodology used in this study is qualitative approach by investigating financial statements of agricultural public listed companies for the year 2011. Thestudy shows that the biological assets recorded in the public listed companies range from consumable biological assets and bearer biological assets. It also shows that many bearer biological assets need more than one reporting period to be ready to produce other biological assets or agriculture produce to be harvest. According to IAS 41, these biological assets should be recorded using fair value model, however this model will not be appropriate. This findings lead to another questions what is the valuation appropriate for biological assets which have different characteristics.

  11. Generation of a Transposon Mutant Library in Staphylococcus aureus and Staphylococcus epidermidis Using bursa aurealis.

    Science.gov (United States)

    Yajjala, Vijaya Kumar; Widhelm, Todd J; Endres, Jennifer L; Fey, Paul D; Bayles, Kenneth W

    2016-01-01

    Transposon mutagenesis is a genetic process that involves the random insertion of transposons into a genome resulting in the disruption of function of the genes in which they insert. Identification of the insertion sites through DNA sequencing allows for the identification of the genes disrupted and the creation of "libraries" containing a collection of mutants in which a large number of the nonessential genes have been disrupted. These mutant libraries have been a great resource for investigators to understand the various biological functions of individual genes, including those involved in metabolism, antibiotic susceptibility, and pathogenesis. Here, we describe the detailed methodologies for constructing a sequence defined transposon mutant library in both Staphylococcus aureus and S. epidermidis using the mariner-based transposon, bursa aurealis.

  12. ANALISIS RASIO KEUANGAN DALAM MEMPREDIKSI LABA YANG AKAN DATANG PADA PERUSAHAAN MANUFAKTUR DI BURSA EFEK INDONESIA

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    Sulistyo Sulistyo

    2011-02-01

    Full Text Available Penelitian ini dilakukan untuk menguji pengaruh rasio profitabilitas (Net Profit Margin (NPM, Return on Investment (ROI dan Return on Equity (ROE, dan rasio penilaian (Price Earning Ratio (PER terhadap prediksi laba yang akan datang. Data diperoleh dengan metode dokumentasi, cara pengambilan sampel menggunakan purposive sampling dengan kriteria (1 Perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia pada periode tahun 2005-2009, (2 Perusahaan manufaktur yang menghasilkan laba setelah pajak selama periode penelitian dan (3 Perusahaan manufaktur yang mengeluarkan NPM, ROI, ROE dan PER bernilai positif selama periode penelitian. Hasil analisis regresi linier berganda dengan tingkat signifikansi sebesar 5% menunjukkan bahwa variabel PER secara parsial berpengaruh positif signifikan terhadap prediksi laba yang akan datang. Sedangkan variabel NPM, ROI, dan ROE tidak berpengaruh signifikan terhadap prediksi laba yang akan datang. Secara bersama-sama menunjukkan bahwa variabel NPM, ROI, ROE dan PER berpengaruh signifikan terhadap prediksi laba yang akan datang 

  13. Signalment Factors, Comorbidity in Behavior Diagnoses in Dogs in Bursa Region, Turkey (2000 - 2004

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    E. Yalcin

    2007-01-01

    Full Text Available The aim of this study was to classify the behaviour problems of dogs reported by owners in the Bursa region. A survey was conducted with the owners of 80 dogs with behaviour problems in 2000 - 2004. The questionnaire consisted of questions related to the demographics of the problems the owners observed in their dogs. Sixty eight dogs were selected from animals referred to the Clinic of the Internal Medicine Department of the Uludag University, Faculty of Veterinary Medicine and 12 dogs were selected at a private kennel. The 68 dogs diagnosed at the clinic as having behaviour problems represented 6.2% of the 1086 patient dogs older than 6 months seen in the same period. Twelve dogs with behaviour problems were selected from a total of 150 dogs at a private kennel. A total of 110 behavioural problems were detected. Some dogs showed more than one behavioural disorder. The classification of the problems was as follows: 65 dogs (59% with aggression, 13 dogs (12% with separation anxiety, 12 dogs (10.5% with phobia of veterinary clinics and high-volume noises such as thunders and fireworks, 12 dogs (10.5% with compulsive disorders (9 dogs with tail chasing, 2 dogs with lick dermatitis, 1 dog with self mutilation, 4 dogs (4% with inappropriate elimination, 2 dogs (2% with coprophagia, and 1 dog (1% with puppy killing, 1 dog (1% with false pregnancy. The breeds most often presented in our study were: German shepherd (19%, Terrier (18%, mixed breed (15%, Anatolian sheepdog (10%. The results of the study showed that behavioural problems are common among dogs in Bursa and aggression ranks first, followed by separation anxiety, phobia and tail chasing.

  14. Contrast-enhanced MRI of the subdeltoid, subacromial bursa in painful and painless rotator cuff tears

    Science.gov (United States)

    Hodgson, R J; O'Connor, P J; Hensor, E M A; Barron, D; Robinson, P

    2012-01-01

    Objective Although shoulder pain is often associated with rotator cuff tears, many tears are asymptomatic and are not the cause of the patient's pain. This may explain the persistence of symptoms in some patients despite technically successful rotator cuff repair. It has been proposed that rotator cuff tears cause pain through subdeltoid/subacromial bursal inflammation. The aim of this study was to determine whether bursal inflammation seen on MRI is associated with pain in patients with rotator cuff tears of the shoulder. Methods The shoulders of 255 patients were screened with ultrasound. 33 full-thickness rotator cuff tears (18 with shoulder pain and 15 without pain) were identified and subsequently studied using contrast-enhanced MRI of the shoulder. Enhancement of the subacromial bursa was scored independently by two musculoskeletal radiologists. Logistic regression was used to determine whether bursal enhancement was independently associated with pain. Results There was a significant association between pain and age, with greater likelihood of pain in younger patients. Bursal enhancement was common in both painful and painless tears. No statistically significant link between pain and bursal enhancement was seen, even after accounting for age. Conclusion Although enhancement of the subdeltoid/subacromial bursa was common, no evidence was found to support the hypothesis that bursal enhancement is associated with pain in rotator cuff tears. It is therefore unlikely to determine reliably which patients would benefit from rotator cuff repair. Advances in knowledge Bursal enhancement and thickening does not reliably correlate with symptoms or presence of rotator cuff tear. PMID:23091289

  15. An Assessment of the Seismicity of the Bursa Region from a Temporary Seismic Network

    Science.gov (United States)

    Gok, Elcin; Polat, Orhan

    2012-04-01

    A temporary earthquake station network of 11 seismological recorders was operated in the Bursa region, south of the Marmara Sea in the northwest of Turkey, which is located at the southern strand of the North Anatolian Fault Zone (NAFZ). We located 384 earthquakes out of a total of 582 recorded events that span the study area between 28.50-30.00°E longitudes and 39.75-40.75°N latitudes. The depth of most events was found to be less than 29 km, and the magnitude interval ranges were between 0.3 ≤ ML ≤ 5.4, with RMS less than or equal to 0.2. Seismic activities were concentrated southeast of Uludag Mountain (UM), in the Kestel-Igdir area and along the Gemlik Fault (GF). In the study, we computed 10 focal mechanisms from temporary and permanents networks. The predominant feature of the computed focal mechanisms is the relatively widespread near horizontal northwest-southeast (NW-SE) T-axis orientation. These fault planes have been used to obtain the orientation and shape factor (R, magnitude stress ratio) of the principal stress tensors (σ1, σ2, σ3). The resulting stress tensors reveal σ1 closer to the vertical (oriented NE-SW) and σ2, σ3 horizontal with R = 0.5. These results confirm that Bursa and its vicinity could be defined by an extensional regime showing a primarily normal to oblique-slip motion character. It differs from what might be expected from the stress tensor inversion for the NAFZ. Different fault patterns related to structural heterogeneity from the north to the south in the study area caused a change in the stress regime from strike-slip to normal faulting.

  16. Histomorphology of bursa of Fabricius: effects of stock densities on commercial broilers

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    EC Muniz

    2006-12-01

    Full Text Available During the past few years, there has been considerable interest on the effects of stocking density on broiler behavior and immunity. Stress may cause immunodeficiency by affecting cell and humoral responses, as well as body weight decrease, and foot-pad dermatitis. The aim of this study was to study histomorphological changes of the bursa of Fabricius in broilers submitted to three different stocking densities (10, 15, and 20 birds/m² from one to 42 days of age. Three birds from each group were sacrifieced on days 7 and 42. The bursa was collected, fixed, and processed for histomorphometric assessment using a Kontrom KS 400 image analyzer. Data were analyzed by Biostat 3.0 (Tukey Test. The results of average cortical area percentage in bursal follicles of 6-week-old birds were 45.12a (10 birds/m², 30.43b (15 birds/m², and 23.77b (20 birds/m². Average body weight was 2.58a kg (10 birds/m², 2.56a Kg (15 birds/m², and 2.47b Kg (20 birds/m², respectively. The percentage of foot-pad dermatitis in 6-week-old birds was 3.33a (10 birds/m², 17.76b (15 birds/m², and 49.17c (20 birds/m². These differences were statistically significant at a P<0.05 level. Under these experimental conditions,, it was concluded that the best stocking density to produce broilers is between 10-15 birds per square meter.

  17. Analysis of gene expression during myc oncogene-induced lymphomagenesis in the bursa of Fabricius

    Science.gov (United States)

    Neiman, Paul E.; Ruddell, Alanna; Jasoni, Christine; Loring, Gil; Thomas, Sandra Jo; Brandvold, Kimberly A.; Lee, Ruey-min; Burnside, Joan; Delrow, Jeffrey

    2001-01-01

    The transcriptional effects of deregulated myc gene overexpression are implicated in tumorigenesis in a spectrum of experimental and naturally occurring neoplasms. In follicles of the chicken bursa of Fabricius, myc induction of B-cell neoplasia requires a target cell population present during early bursal development and progresses through preneoplastic transformed follicles to metastatic lymphomas. We developed a chicken immune system cDNA microarray to analyze broad changes in gene expression that occur during normal embryonic B-cell development and during myc-induced neoplastic transformation in the bursa. The number of mRNAs showing at least 3-fold change was greater during myc-induced lymphomagenesis than during normal development, and hierarchical cluster analysis of expression patterns revealed that levels of several hundred mRNAs varied in concert with levels of myc overexpression. A set of 41 mRNAs were most consistently elevated in myc-overexpressing preneoplastic and neoplastic cells, most involved in processes thought to be subject to regulation by Myc. The mRNAs for another cluster of genes were overexpressed in neoplasia independent of myc expression level, including a small subset with the expression signature of embryonic bursal lymphocytes. Overexpression of myc, and some of the genes overexpressed with myc, may be important for generation of preneoplastic transformed follicles. However, expression profiles of late metastatic tumors showed a large variation in concert with myc expression levels, and some showed minimal myc overexpression. Therefore, high-level myc overexpression may be more important in the early induction of these lymphomas than in maintenance of late-stage metastases. PMID:11353853

  18. Sonography of the iliopsoas tendon and injection of the iliopsoas bursa for diagnosis and management of the painful snapping hip.

    Science.gov (United States)

    Blankenbaker, Donna G; De Smet, Arthur A; Keene, James S

    2006-08-01

    The purpose of this study was to compare sonographic evaluations of patients referred with suspected snapping of their iliopsoas tendon with the pain relief achieved from anesthetic injection of the iliopsoas bursa, and with the subsequent surgical outcome. This study also assessed the effectiveness of Kenalog injection into the iliopsoas bursa for long-term pain relief. Dynamic and static sonography was performed in 40 patients with clinically diagnosed snapping hips. The iliopsoas bursa was injected with Bupivicaine and Lidocaine in the first 22 patients, and an additional 1 ml Kenalog-40 was added to this mixture in the last 18 patients. We compared the static and dynamic sonographic findings with change in the patients' level of pain at 2 days after anesthetic injection. The sonographic findings and response to anesthetic injection were also compared to the response to Kenalog injection and the results of any subsequent surgery. Static sonography of the iliopsoas tendon was normal in 38 patients, and detected iliopsoas bursitis in one patient and iliopsoas tendinopathy in another. Snapping of the iliopsoas tendon was observed using dynamic sonography in 9 of the 40 patients. Following anesthetic injection of the iliopsoas bursa, 29 patients had complete or partial pain relief, and 11 patients had no pain relief. Eight of the nine patients with a snapping iliopsoas tendon had complete or partial pain relief from the bursal injection. Twelve of the 29 patients with pain relief after anesthetic injection later had an arthroscopic iliopsoas tendon release, and all of these 12 patients had a good postoperative result. Of the 18 patients who had Kenalog-40 injected into the iliopsoas bursa and did not have iliopsoas surgery, 16 had sustained pain relief following the injection. Patients with groin pain and a clinically suspected snapping iliopsoas tendon can benefit from injection into the iliopsoas bursa even if the snapping tendon is not visualized sonographically

  19. Gambaran Patologi Bursa Fabricius Embrio Ayam Pascavaksinasi Gumboro Secara In Ovo Menggunakan Vaksin Lokal dan Komersial (PATHOLOGIC DESCRIPTION OF BURSA FABRICIUS CHICKEN EMBYROS AFTER IN OVO VACCINATED WITH LOCAL AND COMMERSIAL GUMBORO VACCINES

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    Sutiastuti Wahyuwardani

    2015-10-01

    Full Text Available Bursa Fabricius is a target organ of gumboro virus infection which is often damaged after vaccinationusing hot intermediate gumboro live vaccine. The purpose of this study was to assess pathologic effect oflocal and commercial gumboro vaccines . As many as 45 embryo chicken eggs at nine day old were used inthis research, then grouped into three groups of 15 embryos chicken eggs each, these were: Embryo chickeneggs without vaccination (Group I, vaccinated with IBD intermediate plus commercial vaccine (Group IIand IBD intermediate plus local vaccine (Group III. Vaccinations were done at 14 days old. All groups thenterminated each three embryos at 12 hours, 1, 2, 3 days post vaccination. The results showed that pathologicanatomic lesions could not be detected. Whereas pathologic lesions were detected in the group that werevaccinated with intermediate plus local IBD observed more severe than in the group that vaccinated withintermediate plus commercial IBD. Lesions such as edema, hemorrhages, necrosis of lymphoid cells wereobserved microscopically in embryo at 12 hours, 1, 2 and 3 days post vaccination in Group II and group III.The lesions were more severe at two days post vaccination causing some lymphoid follicles disappeared at three days post vaccination. However, they were not detected again in the bursa Fabricius three days afterhatching. Cells containing antigens of gumboro were detected in the bursa Fabricius of chicken embryo atone day until three days post vaccination, then disappeared after three days post hatch. It was concludedthat pathologic description of bursa fabricius showed that virus vaccines used for vaccinated IBD in ovowere still virulent, that can cause histopathologic lesions. The viruses are suggested to be more attenuatedbefore using as vaccine in ovo.

  20. ANALISIS VARIABEL YANG MEMPENGARUHI STRUKTUR KEUANGAN INDUSTRI MANUFAKTUR (MAKANAN DAN MINUMAN YANG GO PUBLIK DI BURSA EFEK INDONESIA

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    Jaelani La Masidonda

    2008-10-01

    Full Text Available Penelitian ini bertujuan untuk: (1 mengetahui pengaruh variabel struktur aktiva, pertumbuhan penjualan, beban pajak dan laba ditahan terhadap struktur keuangan, (2 mengetahui variabel yang paling signifikan dan dominan pengaruhnya terhadap struktur keuangan. Populasi penelitian adalah industri manufaktur (makanan dan minuman yang go publik di Bursa Efek Indonesia (BEI sejak 2003-2007 sejumlah 19 perusahaan. Sampel diambil 9 perusahaan yang ditentukan berdasarkan teknik purposive sampling. Data berasal dari data sekunder Bursa Efek Indonesia, terutama laporan keuangan dan informasi perkembangan industri manufaktur (makanan dan minuman dengan menggunakan teknik dokumentasi dan tipe pooled data. Model analisis yang digunakan adalah Regresi Linier Berganda. Hasil penelitian menunjukan bahwa secara simultan variabel struktur aktiva, pertumbuhan penjualan, beban pajak dan laba ditahan berpengaruh signifikan terhadap struktur keuangan, dan secara parsial hanya variabel  struktur aktiva yang tidak berpengaruh signifikan terhadap struktur keuangan.

  1. Analisis Pengaruh Manajemen Modal Kerja terhadap Profitabilitas dalam Industri Consumer Goods yang Terdaftar di Bursa Efek Indonesia

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    Iswandi Iswandi

    2012-05-01

    Full Text Available In this paper we evaluate the relathionship between working capital management and corporate profitability. We used a sample of 29 companies in consumer goods industry listed in the Bursa Efek Indonesia for the period of 2006 – 2008. The results of the evaluation showed that there is statistical significance between profitability, measured through gross profit, and the cash conversion cycle. Empirical findings show that NDAR, NDI, NDAP affect firm profitability negatively, while CCC affects firm profitability positively.  

  2. Influence of Pasteurella multocida and high and low environmental temperatures on adrenals and bursa of Fabricius in turkeys

    Energy Technology Data Exchange (ETDEWEB)

    Simensen, E.; Olson, L.D.; Hahn, G.L.

    1980-01-01

    The morphologic changes in the adrenals and bursa of Fabricius were evaluated from turkeys inoculated with Pasteurella multocida either in the palatine air spaces or via drinking water and maintained at high (33.4-37.4 C), low (2.6-5.3 C), and moderate (19.8-22.4 C) temperatures in temperature-controlled chambers. There was a slight hyperplasia of the adrenal cortical cells and a hypertrophy of the nuclei in the uninoculated turkeys maintained at both high and low temperatures, but these changes were more marked in turkeys maintained at low temperatures. Regardless of the temperature to which the turkeys were exposed, there was an increase in adrenal weight, hyperplasia of the cortical cells, hypertrophy of the nuclei of the cortical cells, and depletion of lipid in the cortical cells in the turkeys that became depressed after inoculation with P. multocida. In the uninoculated turkeys exposed to high temperatures there was a reduction in the weight of the bursa of Fabricius, atrophy of the follicles, and a reduction in the number of lymphocytes within the follicle, which did not occur in the bursae from uninoculated turkeys maintained at low temperatures. In the turkeys inoculated with P. multocida, there was a marked reduction in bursal weight, atrophy of the follicles, and reduction in the number of lymphocytes within the follicles.

  3. Bursa of Fabricius--mitotic index in the follicles of immunized and non-immunized chicks (Gallus domesticus).

    Science.gov (United States)

    Betti, F; Borella, M I

    1979-01-01

    The mitotic index in the cortical compartment of the follicles of the bursa of Fabricius from chicks immunized with sheep red blood cells (SRBC) is always higher when compaired with non-immunized ones. This mitotic index reachs its maximum 6 days after the SRBC injection, coincident with the highest serum antibody titer. The mitotic activity in the cortex of the follicles of the bursa of Fabricius is always higher than that of the medulla during the postembryonic development of chickens (PROCHAZKA, RODAK, KREJCI 1967). Otherwise it is almost established that the cortex is a zone of continuous lymphocyte proliferation, not occuring the same with the medulla. In addition these bursal histological structures are considered as 2 distinct compartments (GROSSI et al. 1974). The purpose of this paper is to study the response in the mitotic index of the cortical and medullary compartments of the follicles of the bursa of immunized and non-immunized chicks. To correlate possible changes in the mitotic index with circulating antibody levels, the serum antibody titer from the same birds was also recorded.

  4. NEIGHBORHOOD NAMES OF BURSA IN THE WRITINGS OF GAZZIZÂDE ABDULLATIF EFENDI - GAZZİZÂDE ABDÜLLATİF EFENDİ’NİN KALEMİNDEN BURSA MAHALLE ADLARI

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    Ayşe Nur SIR DÜNDAR

    2015-08-01

    Full Text Available During the Ottoman period, cities were administrative units representing the existence of central authority and hegemony. It collected several activities and services within the domain and constituted a whole with its sub units in terms of administrative and civil duties. The development of city was dependent on the development of common life areas, which are neighborhoods. It was possible to see this structure, which is the basis of Ottoman urbanism, in Bursa, Edirne, Istanbul and some other Anatolian cities. Particularly Bursa has rapidly grown within the two centuries following the conquest and displayed a fine example of urbanization as a historical and cultural center. The idle fields in the city were allocated to Turkish tribes, new neighborhoods were established and the nearby villages were transformed into neighborhoods, increasing the total number of neighborhoods in the city. Beside this physical development, the newly established neighborhoods were given Turkish names as the old neighborhoods’ names were also made Turkish. Within this context, it was important to create a neighborhood in the localization of Bursa and the names given to those neighborhoods were also important. Because the names of places are the living documents for the habitation (settlement history of a nation. Studies to be conducted on neighborhood names are the research subjects of several social sciences such as sociology and anthropology and also the linguistics. Evaluation of the names of places phonetically and morphologically will contribute to the development of toponomy, which is an important branch of linguistics. This study has reviewed the neighborhood names in Hulâsatü’l-Vefeyât, a work of Gazzizâde Abdüllatif Effendi, which is considered as an urban monograph among the monographs on Bursa. The review was conducted on the copy of the author which was registered in Süleymaniye Library Assad Effendi, numbers 2257. First, information is provided

  5. Frequency of Penetration of the Digital Flexor Tendon Sheath and Distal Interphalangeal Joint Using a Direct Endoscopic Approach to the Navicular Bursa in Horses.

    Science.gov (United States)

    Kane-Smyth, Justine; Taylor, Sarah Elizabeth; García, Eugenio Cillán; Reardon, Richard J M

    2016-04-01

    To evaluate the frequency of inadvertent penetration of the digital flexor tendon sheath (DFTS) and/or distal interphalangeal joint (DIPJ) when using a direct endoscopic approach to the navicular bursa, and to evaluate an alternate direct approach to the navicular bursa. Cadaveric study. Equine cadaver limbs (n = 40 for direct; n = 12 for alternate approach). Four surgeons performed the direct endoscopic approach to the navicular bursa on 10 limbs each. Frequencies of inadvertent synovial penetration and iatrogenic damage were compared between surgeons. Use of an alternate direct approach, adopting a straight parasagittal trajectory, was evaluated by 2 surgeons. Inadvertent synovial penetration occurred in 45% of limbs (DFTS 37.5%; DIPJ 17.5%; and both structures 10%). Successful bursa entry was achieved on the first attempt in 45% of limbs. Significant variation in frequency of inadvertent synovial penetration was observed between surgeons (range 10-80%). Inadvertent synovial penetration did not occur when using the alternate direct technique. Iatrogenic damage to navicular bone fibrocartilage and/or deep digital flexor tendon occurred in 55% of limbs using the direct endoscopic approach and in 0% of limbs using the alternate direct approach. Because of the considerable risk of inadvertent penetration of the DFTS and/or the DIPJ when making a direct endoscopic approach to the navicular bursa, it is advisable to investigate for inadvertent penetration when treating navicular bursa sepsis using a direct approach. The alternate direct technique may reduce the risk of inadvertent penetration; however, the view within the bursa may be restricted. © 2016 The Authors. Veterinary Surgery published by Wiley Periodicals Inc. on behalf of The American College of Veterinary Surgeons.

  6. LUAS PENGUNGKAPAN DAN DAMPAKNYA TERHADAP ASIMETRI INFORMASI PERUSAHAAN DI BURSA EFEK INDONESIA

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    Sigit Kurnianto

    2016-04-01

    Full Text Available Abstrak: Luas Pengungkapan dan Dampaknya Terhadap Asimetri Informasi Perusahaan di Bursa Efek Indonesia (Studi pada Perusahaan Sektor Keuangan. Penelitian ini bertujuan menganalisis pengaruh Corporate Governance dan Karakteristik Perusahaan terhadap Luas Pengungkapan dan pengaruh Luas Pengungkapan terhadap Asimetri Informasi. Studi ini dilakukan pada perusahaan di sektor keuangan yang go public di Indonesia periode 2008 - 2010. Dengan menggunakan multiple regression dan simple regression analysis ditemukan hasil bahwa Komposisi Dewan Komisaris Independen, Ukuran Perusahaan, Profitabilitas berpengaruh positif terhadap Luas Pengungkapan dan Likuiditas berpengaruh negatif terhadap Luas Pengungkapan. Selain itu, Luas Pengungkapan berpengaruh negatif terhadap Asimetri Informasi. Abstract: Extensive Disclosure and Its Impact on Corporate Information Asymmetry in The Indonesia Stock Exchange (Studies in Financial Sector Company. This study aims to analyze the influence of Corporate Governance and Corporate Characteristics on Extensive Disclosure; and the influence of Extensive Disclosure on Information Asymmetry. The study was conducted on companies in the financial sector which have been go public in Indonesia from 2008 to 2010. By using multiple regression and simple regression analysis, the result indicates that The Board of Independent Commissioners Composition, Company Size, Profitability have given positive influence on Extensive Disclosure; and Liquidity negatively affect on Extensive Disclosure. In addition, the influence of Extensive Disclosure has negative effect on Information Asymmetry.

  7. US guided corticosteroid injection into the subacromial-subdeltoid bursa: Technique and approach.

    Science.gov (United States)

    Molini, L; Mariacher, S; Bianchi, S

    2012-02-01

    Local injection of cortisone derivatives, sometimes combined with local anesthetics, is frequently administered in rheumatology as the treatment of choice in para-articular diseases or as an adjuvant to systemic therapy in the treatment of arthritis.One of the most frequent local corticosteroid injections administered in daily clinical practice by rheumatologists, orthopedic surgeons, physiatrists, sports medicine doctors and general practitioners is injection into the subacromialsubdeltoid bursa in the treatment of bursitis and anterior superior impingement syndrome of the shoulder.Before local corticosteroid injection is administered, it is important to identify possible contraindications and to examine the documentation provided by the patient. Absolute contraindications or those related to the procedure should be evaluated by the prescribing physician but also the physician performing the corticosteroid injection should evaluate possible contraindications to make sure that corticosteroid injection is feasible. The present paper describes the ultrasound (US) guided local corticosteroid injection procedure with particular attention to the equipment required, the position of the patient and the examiner as well as the approach. The main advantage of US guidance during corticosteroid injection is the possibility to identify vascular structures, nerves and tendons situated in the needle path in order to avoid these structures and be sure to inject the drug into the appropriate location. When all rules are complied with and the corticosteroid injection is carried out by an experienced physician, it is virtually painless and is performed in just a few minutes.

  8. Estimation of stochastic volatility with long memory for index prices of FTSE Bursa Malaysia KLCI

    Science.gov (United States)

    Chen, Kho Chia; Bahar, Arifah; Kane, Ibrahim Lawal; Ting, Chee-Ming; Rahman, Haliza Abd

    2015-02-01

    In recent years, modeling in long memory properties or fractionally integrated processes in stochastic volatility has been applied in the financial time series. A time series with structural breaks can generate a strong persistence in the autocorrelation function, which is an observed behaviour of a long memory process. This paper considers the structural break of data in order to determine true long memory time series data. Unlike usual short memory models for log volatility, the fractional Ornstein-Uhlenbeck process is neither a Markovian process nor can it be easily transformed into a Markovian process. This makes the likelihood evaluation and parameter estimation for the long memory stochastic volatility (LMSV) model challenging tasks. The drift and volatility parameters of the fractional Ornstein-Unlenbeck model are estimated separately using the least square estimator (lse) and quadratic generalized variations (qgv) method respectively. Finally, the empirical distribution of unobserved volatility is estimated using the particle filtering with sequential important sampling-resampling (SIR) method. The mean square error (MSE) between the estimated and empirical volatility indicates that the performance of the model towards the index prices of FTSE Bursa Malaysia KLCI is fairly well.

  9. The Tail Exponent for Stock Returns in Bursa Malaysia for 2003-2008

    Science.gov (United States)

    Rusli, N. H.; Gopir, G.; Usang, M. D.

    2010-07-01

    A developed discipline of econophysics that has been introduced is exhibiting the application of mathematical tools that are usually applied to the physical models for the study of financial models. In this study, an analysis of the time series behavior of several blue chip and penny stock companies in Main Market of Bursa Malaysia has been performed. Generally, the basic quantity being used is the relative price changes or is called the stock price returns, contains daily-sampled data from the beginning of 2003 until the end of 2008, containing 1555 trading days recorded. The aim of this paper is to investigate the tail exponent in tails of the distribution for blue chip stocks and penny stocks financial returns in six years period. By using a standard regression method, it is found that the distribution performed double scaling on the log-log plot of the cumulative probability of the normalized returns. Thus we calculate α for a small scale return as well as large scale return. Based on the result obtained, it is found that the power-law behavior for the probability density functions of the stock price absolute returns P(z)˜z-α with values lying inside and outside the Lévy stable regime with values α>2. All the results were discussed in detail.

  10. Estimation of stochastic volatility with long memory for index prices of FTSE Bursa Malaysia KLCI

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Kho Chia; Kane, Ibrahim Lawal; Rahman, Haliza Abd [Department of Mathematical Sciences, Faculty of Science, Universiti Teknologi Malaysia, 81310, Johor Bahru (Malaysia); Bahar, Arifah [UTM Centre for Industrial and Applied Mathematics (UTM-CIAM), Universiti Teknologi Malaysia, 81310, Johor Bahru and Department of Mathematical Sciences, Faculty of Science, Universiti Teknologi Malaysia, 81310, Johor Bahru (Malaysia); Ting, Chee-Ming [Center for Biomedical Engineering, Universiti Teknologi Malaysia, 81310, Johor Bahru (Malaysia)

    2015-02-03

    In recent years, modeling in long memory properties or fractionally integrated processes in stochastic volatility has been applied in the financial time series. A time series with structural breaks can generate a strong persistence in the autocorrelation function, which is an observed behaviour of a long memory process. This paper considers the structural break of data in order to determine true long memory time series data. Unlike usual short memory models for log volatility, the fractional Ornstein-Uhlenbeck process is neither a Markovian process nor can it be easily transformed into a Markovian process. This makes the likelihood evaluation and parameter estimation for the long memory stochastic volatility (LMSV) model challenging tasks. The drift and volatility parameters of the fractional Ornstein-Unlenbeck model are estimated separately using the least square estimator (lse) and quadratic generalized variations (qgv) method respectively. Finally, the empirical distribution of unobserved volatility is estimated using the particle filtering with sequential important sampling-resampling (SIR) method. The mean square error (MSE) between the estimated and empirical volatility indicates that the performance of the model towards the index prices of FTSE Bursa Malaysia KLCI is fairly well.

  11. Landmark-Guided and Ultrasound-Guided Approaches for Trochanteric Bursa Injection: A Cadaveric Study.

    Science.gov (United States)

    Mu, Alex; Peng, Philip; Agur, Anne

    2017-03-01

    Trochanteric bursa (TB) injection with local anesthetic and corticosteroid is a treatment for patients suffering from greater trochanteric pain syndrome. Both landmark (LM)-guided and ultrasound (US)-guided methods have been used, but their accuracies have not been determined. This study examined the accuracy of these injections with cadaveric dissection. Twenty-four hip specimens were randomized to receive TB injections with methylene blue under either LM-guided or US-guided approach. After dissection, the locations of the dye were classified into 3 categories: intrabursal, extrabursal, or combined intrabursal and extrabursal. The presence of dye in the intrabursal space with or without extrabursal leak was considered a successful injection. Accuracy was defined as the percentage of successful injection. The accuracies of the LM-guided and US-guided injection were 0.67 (95% confidence interval 0.35-0.90) and 0.92 (95% confidence interval 0.62-1.00), respectively, with no significant difference. This is the first cadaveric study examining the accuracy of both the US-guided and LM-guided techniques for TB injection. Future clinical studies are required to compare the outcomes of LM-guided and US-guided greater trochanteric pain syndrome injection.

  12. Reaksi Harga Saham terhadap Perubahan Dividen Tunai dan Dividend Yield di Bursa Efek Jakarta

    Directory of Open Access Journals (Sweden)

    Sri Mulyati

    2009-08-01

    Full Text Available Penelitian ini merupakan penelitian empiris tentang reaksi harga saham terhadap perubahan dividen tunai dan dividend yields di Bursa Efek Jakarta. Tujuan yang ingin dicapai pada penelitian ini adalah: pertama, untuk menguji apakah harga saham bereaksi positif terhadap pengumuman kenaikkan dividen dan bereaksi negatif terhadap pengumuman penurunan dividen. Kedua, untuk menguji apakah reaksi harga saham yang terjadi dipengaruhi oleh perubahan dividend yield.Penelitian ini menggunakan sampel sebanyak 52 saham perusahaan yang terdiri dari 27 perusahaan yang membayar dividen naik dan 25 perusahaan yang membayar dividen turun. Periode pengamatan pada penelitian ini adalah tahun 1995 dan 1996. data yang digunakan berupa data sekunder yang terdiri dari data harga saham perusahaan, Indeks Harga Saham Gabungan, dividen per lembar saham dan data dividend yield perusahaan. Abonormal return dihitung dengan menggunakan model pasar. Metode statistik yang digunakan untuk pengujian hipotesis adalah uji t.Hasil penelitian menunjukkan bahwa (1 reaksi harga saham positif terhadap kenaikkan dividen yang dibayarkan terjadi pada hari ke 5 sebelum pengumuman, sedangkan reaksi harga saham negatif terhadap penu¬runan dividen yang dibayarkan terjadi pada hari ke 5 setelah pengumuman. Ini menunjukkan bahwa pengumu¬man dividen mengandung informasi. (2 reaksi harga saham tidak dipengaruhi oleh perubahan dividend yield, ini ditunjukkan dari tidak adanya koefisien yang signifikan.

  13. Atmospheric dry deposition fluxes of trace elements measured in Bursa, Turkey.

    Science.gov (United States)

    Tasdemir, Yücel; Kural, Can

    2005-12-01

    Trace element dry deposition fluxes were measured using a smooth, greased, knife-edge surrogate surface (KSS) holding greased Mylar strips in Bursa, Turkey. Sampling program was conducted between October 2002 and June 2003 and 46 dry deposition samples were collected. The average fluxes of crustal metals (Mg, Ca, and Fe) were one to four orders of magnitude higher than the fluxes of anthropogenic metals. Trace element fluxes ranged from 3 (Cd) to 24,230 (Ca) microg m(-2) d(-1). The average trace element dry deposition fluxes measured in this study were similar to those measured in other urban areas. In addition, ambient air samples were also collected simultaneously with flux samples and concentrations of trace elements, collected with a TSP sampler, were between 0.7 and 4900 ng m(-3) for Cd and Ca, respectively. The overall trace element dry deposition velocities, calculated by dividing the fluxes to the particle phase concentrations ranged from 2.3+/-1.7 cm s(-1) (Pb) to 11.1+/-6.4 cm s(-1) (Ni). These values are in good agreement with the values calculated using similar techniques. The anthropogenic and crustal contributions were estimated by employing enrichment factors (EFs) calculated relative to the average crustal composition. Low EFs for dry deposition samples were calculated. This is probably due to contamination of local dust and its important contribution to the collected samples.

  14. Calcaneus, calcaneal tendon and retrocalcaneal bursa. Historical overview and plea for an accurate terminology.

    Science.gov (United States)

    Kachlik, D; Musil, V; Vasko, S; Klaue, K; Stingl, J; Baca, V

    2010-01-01

    Diseases and injuries of several specific structures in the heel region have been an enduring focus of medicine: The anatomical terminology of many of these structures has not been established until recently. The aim of the study was a historical analysis of the advances of anatomical terminology of three selected morphological units in the heel region--the Achilles tendon, calcaneus and retrocalcaneal bursa. It starts with a critical evaluation of the mythological eposes, the Illiad and Odyssey, describing the exploits of heroes in the Trojan war, followed by a review of relevant terms used for the designation of selected heel structures in the Middle Ages as well as in the 18" and 19" centuries. Principal versions of Latin anatomical terms used for the denotation of the mentioned structures are discussed. Recently applicable Latin terms and their recommended English synonyms, according to the latest version of Terminologia Anatomica (1998) are summed up. It surveys examples of "not very appropriate" terms, which are frequently used in clinical literature. The authors consider the use of official anatomical terms (both Latin and English) as an important step for the improvement of the clinical expressions and formulations.

  15. US guided corticosteroid injection into the subacromial-subdeltoid bursa: Technique and approach

    Science.gov (United States)

    Molini, L.; Mariacher, S.; Bianchi, S.

    2012-01-01

    Local injection of cortisone derivatives, sometimes combined with local anesthetics, is frequently administered in rheumatology as the treatment of choice in para-articular diseases or as an adjuvant to systemic therapy in the treatment of arthritis. One of the most frequent local corticosteroid injections administered in daily clinical practice by rheumatologists, orthopedic surgeons, physiatrists, sports medicine doctors and general practitioners is injection into the subacromialsubdeltoid bursa in the treatment of bursitis and anterior superior impingement syndrome of the shoulder. Before local corticosteroid injection is administered, it is important to identify possible contraindications and to examine the documentation provided by the patient. Absolute contraindications or those related to the procedure should be evaluated by the prescribing physician but also the physician performing the corticosteroid injection should evaluate possible contraindications to make sure that corticosteroid injection is feasible. The present paper describes the ultrasound (US) guided local corticosteroid injection procedure with particular attention to the equipment required, the position of the patient and the examiner as well as the approach. The main advantage of US guidance during corticosteroid injection is the possibility to identify vascular structures, nerves and tendons situated in the needle path in order to avoid these structures and be sure to inject the drug into the appropriate location. When all rules are complied with and the corticosteroid injection is carried out by an experienced physician, it is virtually painless and is performed in just a few minutes. PMID:23396761

  16. Evaluation of User Satisfaction in Relation to Comfort Conditions in Shopping Malls: Bursa as a Case

    Directory of Open Access Journals (Sweden)

    Filiz ŞENKAL SEZER

    2014-04-01

    Full Text Available Enclosed shopping malls are one of the most preferred spaces in our daily lives. In these places, visual and climatic comfort conditions of the users are generally provided by artificial systems instead of natural ones. In order to provide user satisfaction which is one of the most important requirements for the viability of these centers, the usage of these artificial systems causes higher energy consumption. In this study, it is argued that spatial organization scheme of shopping malls affects the subjective thoughts of the users’ interior comfort conditions (thermal, interior space air quality, natural ventilation, day lighting, audial comfort. In this context, 7 large shopping malls in Bursa were selected as case studies and the questionnaire aiming to evaluate the users’ satisfaction about comfort conditions in these shopping malls was carried out. The aim of the study is to identify the effects of architectural design principles and spatial organization schemes on the users’ evaluation of comfort conditions. The results of the questionnaire are classified under subtitles such as interior heat, thermal comfort, interior air quality and natural ventilation, day lighting, audial comfort .In this context, at the end of the study, the relation between the users’ subjective evaluation of comfort conditions and architectural design principles are comparatively discussed and some suggestions for the design of new shopping malls are provided

  17. Pengumuman Dividen Reguler terhadap Future Unexpected Earnings: Suatu Penelitian Empiris di Bursa Efek Jakarta

    Directory of Open Access Journals (Sweden)

    Dedi Herdiansyah

    2009-08-01

    Full Text Available Hasil-hasil penelitian terdahulu tentang apakah dividen mengandung informasi yang berguna bagi pasar masih saling bertentangan. Hasil penelitian Natts (1973, 1976, Ang (1975 dan Gonedes (1978 tidak menemukan bukti bahwa pengumuman dividen mengandung informasi. Sedangkan hasil penelitian terbaru yang dilakukan Laub (1976, Charest (1978, Aharony dan Swary (1980, Woolridge (1982, Asquith dan Mullins (1988, Venkantesh dan Chiang (1986. Healy dan Seifert (1992, dan Mande (1994 mendukung bahwa pengumuman dividen mengandung informasiPenelitian ini merupakan replikasi dari dari model penelitian yang dilakukan oleh Aharony dan Dotan (1994. Penelitian ini mencoba untuk mempertegas konfirmasi dari observasi-observasi yang mengungkapkan bahwa peningkatan (penurunan harga saham. Populasi penelitian ini adalah seluruh perusahaan yang terdaftar di Bursa Efek Jakarta (BEJ dengan periode pengumuman dividen tahun 1992 – 1995. Pemilihan periode tersebut dilakukan sebelum Indonesia mengalami krisis untuk menghindari bias karena selama krisis banyak saham yang menjadi kurang atraktif Hasil penelitian ini menunjukkan bahwa pengumuman perubahan dividen tidak berpengaruh secra signifikan terhadap peningkatan (penurunan keuntungan perusahaan. Hasil penelitian juga memberikan indikasi bahwa pengumuman dividen tidak memiliki kandungan informasi ke pasar. Peningkatan (penurunan dividen lebih disebabkan keuntungan perusahaan pada periode yang sama dengan dilakukannya pengumuman dividen. Hal ini mengindikasikan bahwa peningkatan (penurunan dividen tidak menggambarkan peluang profitable perusahaan di waktu yang akan datang.      Kata kunci: unexpected dividen change, future unexpected earnings, and information content of dividend.  

  18. Evaluation of genotoxicity from Nilufer Stream (Bursa/Turkey) water using piscine micronucleus test.

    Science.gov (United States)

    Summak, Senay; Aydemir, Nilufer Cinkilic; Vatan, Ozgür; Yilmaz, Dilek; Zorlu, Tolga; Bilaloğlu, Rahmi

    2010-01-01

    In the present study, the in vivo micronucleus (MN) test in fish erythrocytes was used to evaluate the genotoxic potentials of water samples collected from four different sites along the Nilufer Stream which empties into the Marmara Sea on the north-west of Turkey. Nilufer Stream receives discharges of industrial and domestic wastes resulting from industrialization and urbanization activities in Bursa city. Nile tilapias (Oreochromis niloticus) were exposed to collected water samples under laboratory conditions for 3 and 6 days. Micronuclei analyses were carried out in peripheral blood erythrocytes. In addition to micronuclei, other nuclear abnormalities (NAs) such as bi-nucleated cells and binuclei with nucleoplasmic bridge and cells with blebbed, notched and lobbed nuclei, were assessed in the erythrocytes. Chemical analyses were also carried out in the water samples to assess the presence of major pollutants. MN and NA frequencies were significantly elevated in fishes exposed to water from polluted areas compared to those exposed to clean water sample. The results of this study indicate that Nilufer Stream is contaminated with potential genotoxic chemicals and the genotoxicity is possibly related with the industrial, agricultural and domestic activities. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

  19. ANALISIS PENGARUH EVA DAN MVA TERHADAP RETURN SAHAM PADA INDUSTRI PROPERTI DI BURSA EFEK INDONESIA PERIODE 2007-2012

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    Ryan Pahlawan

    2015-04-01

    Full Text Available Abstrak: Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis: (1 pengaruh Economic Value Added (EVA terhadap return saham (2 pengaruh Market Value Added (MVA terhadap return saham (3 pengaruh Economic Value Added (EVA dan Market Value Added (MVA terhadap return saham antara variabel kinerja keuangan industri properti di Bursa Efek Indonesia pada periode 2007-2012. Kegunaan teoritis adalah untuk memberikan kontribusi tentang pengetahuan manajemen keuangan, yang dapat digunakan sebagai acuan untuk penelitian berikutnya kinerja keuangan terutama tentang industri properti di Bursa Efek Indonesia. Kegunaan praktis adalah untuk mengetahui pengaruh tingkat Economic Value Added (EVA dan Market Value Added (MVA terhadap kinerja keuangan untuk kontribusi memberi kepada manajemen properti umum dalam mengelola variabel kinerja industri properti Bursa Efek Indonesia.Penelitian ini menggunakan data sekunder yang dikumpulkan dari data Bursa Efek Indonesia, dan Departemen Riset menurut sifat laporan keuangan pada periode 2007-2012. Sampel adalah 54 variabel dan dianalisis dengan regresi berganda metode statistik linier. Total nilai determinasi adalah 0,368, artinya ini adalah 36,8% informasi dalam data dapat dijelaskan oleh model dan 63,2% di bawah variabel lain dan error. Kesimpulan dari penelitian ini adalah: (1 Variabel Economic Value Added (EVA berpengaruh positif terhadap return saham; (2 Variabel Market Value Added (MVA memiliki pengaruh negatif terhadap Return Saham; Mengacu pada kesimpulan penelitian diatas maka disarankan adalah: (1 Dioptimalkan Economic Value Added (EVA untuk mencapai pendapatan dan keuntungan dari return saham (2 Mengelola Variabel Market Value Added (MVA pada kondisi baik untuk menjaga stabilitas keuangan dan mendapatkan dipercaya dari investor Bursa Efek Indonesia (3 Fokus ke Manajemen Risiko, Jasa, perusahaan Visi & Misi, dan Active keterampilan dan pengetahuan karyawan perusahaan yang lebih tinggi untuk

  20. ECONOMY AND CULTURE IN TRANSITIONS: A COMPARATIVE STUDY OF TWO ARCHITECTURAL HERITAGE SITES OF BAZARS AND HANS OF BURSA AND DHAKA

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    Tasleem Shakur

    2013-11-01

    Full Text Available Chawkbazar in Dhaka and Covered Bazaar in Bursa are two unique examples showing the contradiction among the traditional and the contemporary life-styles and their reflections on space uses and architecture. The first example in Dhaka is one of the prime icons of Mughal architecture in Bangladesh, whereas the second one in Bursa is the first example of the typical nucleus of traditional Ottoman city. Based on these two case studies in Dhaka (Bangladesh and Bursa (Turkey, this paper attempts to illustrate how the emerging cultures and spaces are continuously being either negotiated or contested with their adjacent historic sites (Shakur, 2005. This comparative research between two similar historical sites (Mughal and Ottoman but miles apart geographically is intended to understand the commonalities in its economic, social, cultural aspects through its transformation from the historic to the contemporary period. It highlights the socio-economic and cultural transformation and its implications for future conservation and development.

  1. Solitary Osteochondroma of the Ventral Scapula Associated with Large Bursa Formation and Pseudowinging of the Scapula: A Case Report and Literature Review

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    Kiyohisa Ogawa

    2018-01-01

    Full Text Available Osteochondroma (OC is the most common benign bone tumor and may occur on any bone in which endochondral ossification develops. Although scapular OC accounts for less than 5% of the cases of solitary OC, OC is the most common lesion among the tumors and tumor-like lesions of the scapula. OC that develops near the medial scapular border easily causes friction with the ribcage; hence, almost half the number of cases of OC associated with marked bursa formation develops in the ventral scapula. We report a case of a 27-year-old female with a painful OC of the ventral scapular surface associated with large bursa formation and pseudowinging of the scapula. After l2 years of follow-up with magnetic resonance imaging, we confirm that the accompanied bursa left at surgery disappears.

  2. Giant Cell Tumor of the Pes Anserine Bursa (Extra-Articular Pigmented Villonodular Bursitis): A Case Report and Review of the Literature

    Science.gov (United States)

    Zhao, Haitao; Maheshwari, Aditya V.; Kumar, Dhruv; Malawer, Martin M.

    2011-01-01

    Pigmented villonodular synovitis (PVNS) is a rare, benign, proliferating disease affecting the synovium of joints, bursae, and tendon sheaths. Involvement of bursa (PVNB, pigmented villonodular bursitis) is the least common, and only few cases of exclusively extra-articular PVNB of the pes anserinus bursa have been reported so far. We report a case of extra-articular pes anserine PVNB along with a review of the literature. The lesion presented as a painful soft tissue mass in the medial part of the proximal leg. A magnetic resonance imaging showed areas of low to intermediate signals in all sequences and the lesion enhanced heterogeneously with contrast. Diagnosis was confirmed by an incisional biopsy, and an intralesional resection was performed. The postoperative course was uneventful, and the patient is free of disease with no functional deficit at 2 years followup. As with other rare lesions, clinical and radiographic findings in addition to histological examination are essential for correct diagnosis. PMID:21687595

  3. Outcomes of podotrochlear (navicular) bursa injections for signs of foot pain in horses evaluated via magnetic resonance imaging: 23 cases (2005-2007).

    Science.gov (United States)

    Bell, Chris D; Howard, Rick D; Taylor, D Scott; Voss, Ed D; Werpy, Natasha M

    2009-04-01

    To determine clinical outcome following intrathecal injection of the podotrochlear (navicular) bursa for signs of foot pain in horses evaluated via magnetic resonance imaging (MRI) and evaluate efficacy of corticosteroids administered with or without hyaluronate. Retrospective case series. 23 horses. Data collected included signalment, history, intended use, duration and severity of lameness, results of diagnostic anesthesia, radiographic abnormalities, MRI abnormalities, and outcomes for return to use. MRI was conducted on 23 horses with lameness localized to the foot. Thirteen horses had bilateral forelimb lameness, and 10 had unilateral forelimb lameness. Mean duration of lameness was 10.5 months. Seventeen of 23 (74%) horses had excellent outcomes and returned to intended use within 2 to 4 weeks after navicular bursa injection. Hyaluronate treatment was not associated with outcome; however, horses receiving bursa should be highly effective in alleviating lameness.

  4. Dynamic ultrasound of the subacromial-subdeltoid bursa in patients with shoulder impingement: a comparison with normal volunteers.

    Science.gov (United States)

    Daghir, Ahmed A; Sookur, Paul A; Shah, Sachit; Watson, Martin

    2012-09-01

    The purpose of the study was to determine if the thickness of the subacromial-subdeltoid (SASD) bursa during dynamic ultrasound and on static views differs between patients with shoulder impingement syndrome and healthy volunteers. Twenty-two patients with a clinical diagnosis of shoulder impingement syndrome and 23 healthy volunteers were recruited. A subset of patients showing an immediate symptom response following intrabursal injection was identified as "injection responders". Ultrasound of the shoulder was performed on all participants using three standard static views and two dynamic views (before and after arm abduction). The thickness of both the intrabursal fluid and the superficial peribursal fat was measured on all views. The bursal thickness measurements in the two groups were compared using a t test for significance. The mean increase in SASD bursal fluid thickness following arm abduction was not statistically different among all patients (0.39 ± 0.41 mm) and controls (0.35 ± 0.32 mm), p = 0.72. The same was true comparing injection responders (0.46 ± 0.49 mm) with controls, p = 0.41. On static views, greater bursal fluid thickness was found in patients (1.01 ± 0.48 mm) compared with controls (0.67 ± 0.32 mm) when using the short axis view of the supraspinatus, p = 0.006. No statistically significant difference was found between injection responders and controls when measuring peribursal fat thickness on any view. Gathering of the SASD bursa demonstrated during dynamic ultrasound does not necessarily indicate painful impingement of the bursa as it is found to a similar degree in patients with a clinical diagnosis of impingement and healthy volunteers.

  5. DETERMINAN PENGUNGKAPAN SUSTAINABILITY REPORT PADA PERUSAHAAN YANG TERDAFTAR DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Sri Wiwik Anggiyani

    2017-05-01

    Full Text Available Penelitian ini bertujuan untuk memperoleh bukti secara empiris pengaruh tipe industri, independensi komite audit, ukuran perusahaan, rasio leverage (DER, rasio profitabilitas (ROA terhadap pengungkapan sustaianbility report. Populasi dalam penelitian ini adalah seluruh perusahaan yang terdaftar di Bursa Efek Indonesia (BEI tahun 2009-2013. Teknik pengambilan sampel dilakukan dengan menggunakan metode purposive sampling yang menghasilkan 26 dari tahun 2009 – 2013. Alat analisis untuk menguji hipotesis adalah path analysis dengan software AMOS versi 21. Hasil penelitian ini menunjukkan bahwa tipe industri berpengaruh negatif dan signifikan terhadap ukuran perusahaan, selanjutnya tipe industri berpengaruh negatif dan signifikan terhadap rasio leverage, kemudian ukuran perusahaan berpengaruh positif dan signifikan terhadap rasio leverage. Rasio leverage berpengaruh negatif dan signifikan terhadap profitabilitas dan rasio leverage berpengaruh negatif dan signifikan terhadap pengungkapan sustainability report. Juga ukuran perusahaan yang berpengaruh positif dan signifikan terhadap pengungkapan sustainability report. The aim of this study was to obtain empirical evidence of the impact of the type of industry, the independency audit committee, company size, leverage ratio (DER, profitability ratio (ROA to the sustainability report. The population on this research is all the company that registered in Indonesia Stock Exchange (IDX on 2009-2013. The sampling technique was conducted using purposive sampling method. Base on this method, obtained the sample of 26 companies since 2009-2013. This research used path analysis software with AMOS version 21 as the instrument to test the hypothese. The result of this research shows that the type of the industry negatively affect and significant to the company size. Next, the type of the industry negatively affect and significant to leverage ratio, then company’s standard positively affect and significant to

  6. Geomorphological investigation of the excavation-induced Dundar landslide, Bursa, Turkey

    Energy Technology Data Exchange (ETDEWEB)

    Erginal, A.E.; Turkes, M.; Ertek, T.A.; Baba, A.; Bayrakdar, C. [Canakkale Onsekiz Mart University, Canakkale (Turkey). Faculty for Science & Arts

    2008-07-01

    This paper discusses the occurrence and development of the excavation-induced deep-seated landslide, which took place near Dundar village, located west of Orhaneli town in northwestern Turkey. The event occurred in the Bursa-Orhaneli lignite field. Due to undermining of a gently inclined slope (10{sup o}) to extract a coal seam, primary tension cracks, which were precursors of the movement, were first observed in the northern head area in mid- to late October 2003. This movement happened simultaneously with precipitation that was significantly above long-term average measured at a nearby climatology station (Keles). Daily climatic and synoptic meteorological data have proved that heavy showers in late April may have triggered the last slump by producing rain showers of 19.3 mm and 19.9 mm daily total on 27 and 28 April 2004, respectively. Field observations carried out along the main head scarp have shown that the slope failure was facilitated by a pre-existing normal fault with an east-west direction and 80{sup o} dip. Grain-size analysis showed that the failure occurred on clayey silt, which forms 55% of the slip surface material. The landslide occurred over an area of 600 m x 650 m with a total volume of 8775 000 m{sup 3}. Approximately 28 hectares of farm land were entirely destroyed and the excavated coal seam was buried. The mining operation was moved to 100 m north of the landslide area near Gumuspinar village. From morphological evidence, it is concluded that excavation activities caused the failure to extend in more than one direction as an enlarging sliding mechanism; this produced a high landslide risk for Gumuspinar village, where the most significant normal fault with a 75 m vertical displacement in a coal-bearing sequence is found in the lignite field.

  7. Ore Mineralogy Features of Hayriye and Arapdede Mineralizations in (Inegol-Bursa) Area

    Science.gov (United States)

    Sendir, Hüseyin; Kocatürk, Hüseyin; Cesur, Duru; Toygar, Özlem

    2016-04-01

    Western Anatolia (Turkey) experienced widespread Cenozoic magmatism after the collision between the Sakarya and Anatolide-Tauride continental blocks in the pre-middle Eocene. The widespread magmatic activity in NW Anatolia postdates this continental collisional event in the region. The following magmatic episode during the Oligocene and Early Miocene is known to have produced the widespread granitic plutons. Many skarn mineralization associated with plutons formed in the region (such as Hayriye and Arapdede Mineralizations). The Paleozoic aged Devlez Metabasite is the oldest unit of the study area. This unit includes amphibolite, glaucophane-lawsonite schist, muscovite schists. The unit has widely spread in area. This units are overlain unconformably by the Geyiktepe Marbles. Paleocene aged Domaniç granitoidic intrusives cut other rock series and located as a batholite. Magmatic units present porphyric and holocrystalline textures. Granitoidic intrusions are represented by tonalite, tonalite porphyr, granodiorite, granodiorite porphyr, granite, diorite, diorite porphyries. The Domaniç granitoid intruded in to the metamorphides during Paleocene and caused formations of skarn zones and related Cu-Pb-Zn mineralizations along the contacts. Mineralizations are known in the locations named as Arapdede and Hayriye. The mineralizations occur along the metamorphites - plutonics contact, in the pockets and fractures extending towards marble. The thickness of the mineralized bodies can reach up to 1 -2 m. Primary minerals are galenite, magnetite, pyrite, chalcopyrite and sphalerite at Hayriye mineralizations and sphalerite, galenite, chalcopyrite and pyrite minerals at the Arapdede mineralizations. This study supported by ESOGU BAP (201115031) Keywords: Ore mineralogy, mineralization, Cu-Pb-Zn deposits, Inegöl (Bursa).

  8. Consanguineous Marriages among Women in Bursa Nilufer Public Health Training and Research Area

    Directory of Open Access Journals (Sweden)

    Nilufer Tavukcu

    2008-04-01

    Full Text Available AIM/BACKGROUND: The aim of this study was to evaluate socio-demographic and fertility features, opinions on consanguinity, and the types of congenital disorders encountered in the babies of women in consanguineous marriages in the Nilufer Public Health Training and Research Area in the province of Bursa in northwest Turkey. METHODS: This case-control study was conducted between September 2005 and March 2006. The case group consisted of 393 women in consanguineous marriages in the Nilufer Public Health Training and Research Area; the control group consisted of 393 women of similar age living in the same neighborhoods but in non-consanguineous marriages. RESULTS: Women involved in a consanguineous marriage were on average younger than women in the control group. The mean numbers of pregnancies, births, stillbirths, and living and deceased babies were all significantly higher among the consanguineous marriages. When the sample and the control groups were compared, it was obtained that the women in the case group were socio-economically in a lower status statistically, by means of their husband’s and their own education and occupational status, than the women in the control group. The women in the case group were more likely to believe that consanguinity is not detrimental to a child’s health, and they approved of consanguineous marriages for their own children. These opinions were held despite there being a significantly higher incidence of congenital disorders among the children of the consanguineous marriages. CONCLUSION: Women there should be offered genetic counseling to help reduce the occurrence of children being born with congenital abnormalities. [TAF Prev Med Bull. 2008; 7(2: 107-112

  9. Prevalence & risk factors of anaemia among women of reproductive age in Bursa, Turkey.

    Science.gov (United States)

    Pala, Kayihan; Dundar, Nilgun

    2008-09-01

    The control of anaemia in women of childbearing age is essential to prevent low birth weight and perinatal and maternal mortality. The aim of this study was to determine the anaemia prevalence and risk factors in women of reproductive age group in Nilufer Public Health Training and Research Area, Bursa, Turkey. In this cross-sectional study, 530 women were selected using stratified random sampling among 6,506 women in 15-49 age group and 488 women (92.1%) participated in the study. Pregnant women or women who were not sure of their pregnancy were not included in the study. The data collected were analysed by multivariate logistic regression analysis to determine the risk factors related to anaemia. The prevalence of anaemia was 32.8 per cent (haemoglobin level < 12 g/dl). Usage of more than 2 sanitary pads in a day during menstruation (OR=3.67, 95% CI 2.30-5.88; P=0.000) and duration of menstrual bleeding more than 5 days (OR=3.01, 95% CI 1.94-4.66; P=0.000) were found to be risk factors for anaemia. Approximately 1 of 3 women in the study area was diagnosed to be anaemic. These data indicated the necessity of a public health programme for prevention and early diagnosis of anaemia. Starting from adolescence, all non pregnant women should be screened for anaemia every 5-10 yr throughout their childbearing years during routine health examinations. The follow up service provided by midwives at the primary health care can be used as a suitable tool for anaemia prevention.

  10. Consanguineous Marriages among Women in Bursa Nilufer Public Health Training and Research Area

    Directory of Open Access Journals (Sweden)

    Nilufer Tavukcu

    2008-04-01

    Full Text Available AIM/BACKGROUND: The aim of this study was to evaluate socio-demographic and fertility features, opinions on consanguinity, and the types of congenital disorders encountered in the babies of women in consanguineous marriages in the Nilufer Public Health Training and Research Area in the province of Bursa in northwest Turkey. METHODS: This case-control study was conducted between September 2005 and March 2006. The case group consisted of 393 women in consanguineous marriages in the Nilufer Public Health Training and Research Area; the control group consisted of 393 women of similar age living in the same neighborhoods but in non-consanguineous marriages. RESULTS: Women involved in a consanguineous marriage were on average younger than women in the control group. The mean numbers of pregnancies, births, stillbirths, and living and deceased babies were all significantly higher among the consanguineous marriages. When the sample and the control groups were compared, it was obtained that the women in the case group were socio-economically in a lower status statistically, by means of their husband’s and their own education and occupational status, than the women in the control group. The women in the case group were more likely to believe that consanguinity is not detrimental to a child’s health, and they approved of consanguineous marriages for their own children. These opinions were held despite there being a significantly higher incidence of congenital disorders among the children of the consanguineous marriages. CONCLUSION: Women there should be offered genetic counseling to help reduce the occurrence of children being born with congenital abnormalities. [TAF Prev Med Bull 2008; 7(2.000: 107-112

  11. Preservation of the ulnar bursa within the carpal tunnel: does it improve the outcome of carpal tunnel surgery? A randomized, controlled trial.

    Science.gov (United States)

    Forward, D P; Singh, A K; Lawrence, T M; Sithole, J S; Davis, T R C; Oni, J A

    2006-11-01

    It was hypothesized that preserving a layer of gliding tissue, the parietal layer of the ulnar bursa, between the contents of the carpal tunnel and the soft tissues incised during carpal tunnel surgery might reduce scar pain and improve grip strength and function following open carpal tunnel decompression. Patients consented to randomization to treatment with either preservation of the parietal layer of the ulnar bursa beneath the flexor retinaculum at the time of open carpal tunnel decompression (fifty-seven patients) or division of this gliding layer as part of a standard open carpal tunnel decompression (sixty-one patients). Grip strength was measured, scar pain was rated, and the validated Patient Evaluation Measure questionnaire was used to assess symptoms and disability preoperatively and at eight to nine weeks following the surgery in seventy-seven women and thirty-four men; the remaining seven patients were lost to follow-up. There was no difference between the groups with respect to age, sex, hand dominance, or side of surgery. Grip strength, scar pain, and the Patient Evaluation Measure score were not significantly different between the two groups, although there was a trend toward a poorer subjective outcome as demonstrated by the questionnaire in the group in which the ulnar bursa within the carpal tunnel had been preserved. Preserving the ulnar bursa within the carpal tunnel did, however, result in a lower prevalence of suspected wound infection or inflammation (p = 0.04). In this group of patients, preservation of the ulnar bursa around the median nerve during open carpal tunnel release produced no significant difference in grip strength or self-rated symptoms. We recommend incision of the ulnar bursa during open carpal tunnel decompression to allow complete visualization of the median nerve and carpal tunnel contents.

  12. Treatment and outcome with traumatic lesions of the olecranon and prepatellar bursa: a literature review apropos a retrospective analysis including 552 cases.

    Science.gov (United States)

    Raas, Christoph; Attal, René; Kaiser, Peter; Popovscaia, Marina; Zegg, Michael

    2017-06-01

    Traumatic lesions of the olecranon bursa (OB) and prepatellar bursa (PB) are injuries commonly seen in orthopaedic trauma units. These injuries are associated with a high rate of complications. At present, only little is known about the incidence, complication rate, and treatment approaches in patients with acute open bursae. A total of 552 patients who had been treated for acute traumatic lesions of either the olecranon bursa or the prepatellar bursa, or both at our department were retrospective identified in the years between 2009 and 2014. An analysis of the medical history of these patients was carried out to investigate the incidence of bursa injuries, circumstances, concomitant injuries, complication rate, and treatment approaches. In addition, a systematic literature search on PubMed was conducted. The incidence of traumatic lesions of the OB or PB in trauma patients was 0.2% (198/100,000; 62% OB, 38% PB). Bursectomy was performed in 83.7%. Concomitant injuries were present in 41% of the cases, with no significant influence on the complication rate (P = 0.367). The overall complication rate was 19.7%. Revision surgery was necessary in 4.5% of the patients. No significant differences between OB and PB injuries were noted with regard to the complication rate (P = 0.221). There were also no significant differences in the complication rate between patients who received bursectomy and those with conservative treatment (P = 0.364). Regression analyses showed that prophylactic antibiotic administration significantly reduced the risk of infection (P = 0.04). Traumatic lesions of the OB and PB are associated with a high risk of complications. Prophylactic antibiotic therapy can potentially reduce the risk of infection and the need for revision surgery.

  13. Geophysical/Geotechnical Applications to Urban Transformation: Example of District of Yildirim of Bursa City

    Science.gov (United States)

    Karabulut, Savas; Imre, Nazire; Yeziz, Hatice; Caglak, Faruk; Tezel, Okan; Ozcep, Ferhat

    2013-04-01

    The city of Bursa, which is located near to the North Anatolian Fault Zone has a very active tectonic regime. The city has a local site effect problem, which is the subject of many studies for this region due to take place in the middle of the basin of the city center. However, in line with the law of new urban transformation, Turkey has started renovation of damaged old buildings and sub-urban buildings. The first example of study has been conducted in Bursa City Center in the district of Yıldırım and that has covered a big area. We used Turkish/Eurocode-8 Standard and Microzonation Criteria for all of this study. The study area covered 7 sub-district areas in particular the southern part of the conservancy district of the plains and northern part of the Uludag slope. We carried out geophysical (microtremors, seismic refraction method, surface wave analysis methods (MASW-MAM) and vertical electrical sounding) and geotechnical (boring up to 20 m and laboratory testing) studies at 75 sites to estimate elastical parameters, soil group, soil classification, and geological cross-sections. The study area was divided into two sub-areas as slope rubble (in the southern part) and alluvial deposits by using borehole data. Standard penetration tests were applied for each 1.5 m to all the boreholes and to estimate mechanical and index properties of soils, several laboratory test were applied to soil/rock specimens. Several soil problems such as soil bearing capacity, soil liquefaction potential, soil settlement analysis, soil amplification, soil expansion analysis were solved by using the results of geophysical, geotechnical and laboratory data. For the study area, deterministic and probabilistic earthquake hazard analysis was performed and ground motion level (magnitude and accelaration of design earthquake) was estimated as Mw:7.4 and a: 0.41 g for exceedence rate of 30% in 50 years. These values guided the solution of soil dynamic analysis. Vs30 map of soils for the

  14. Factors Associated with the Outcome of Ultrasound-Guided Trochanteric Bursa Injection in Greater Trochanteric Pain Syndrome: A Retrospective Cohort Study.

    Science.gov (United States)

    Park, Ki Deok; Lee, Woo Yong; Lee, Jihae; Park, Min-Ho; Ahn, Jae Ki; Park, Yongbum

    2016-05-01

    Trochanteric bursa injections of corticosteroids and local anesthetics have been shown to provide pain relief for the treatment of greater trochanteric pain syndrome (GTPS). However, symptom recurrence and incomplete symptom relief are common. The reason for the variation in response is unclear but may be related to disease-, treatment-, or patient-related factors. To determine whether there are factors related to patient, treatment, or disease that can predict either the magnitude or duration of response to ultrasound-guided trochanteric bursa injections for GTPS. Retrospective evaluation. A university hospital outpatient center. Potential study participants were patients who underwent ultrasound-guided trochanteric bursa injection at an outpatient rehabilitation department. Follow-up interviews were performed in a hospital visit at 1, 3, and 6 months after injection. The Harris Hip Score and the Verbal Numeric Pain Scale were used to evaluate clinical effectiveness of pain reduction and functional improvement at baseline, 1, 3, and 6 months after treatment. Clinical data and ultrasound findings were obtained to assess the possible predictive factors for a good and durable response to ultrasound-guided trochanteric bursa injection. Patients receiving ultrasound-guided trochanteric bursa injections had a statistically significant improvement in pain and hip function at 1, 3, and 6 months after the last injections. Of the 137 patients, 110 (80.3%), 95 (64.9%), and 77 (56.2%) patients achieved successful outcomes according to their 1, 3, and 6-month follow-up evaluations, respectively. Univariate analysis showed that patients with knee osteoarthritis and lumbar facet joint or sacroiliac joint pain experienced less therapeutic effect than those without the conditions at 6 months post-injection. Logistic regression analysis showed that the significant outcome predictors at the 6-month follow-up were facet joint or S-I joint pain (odds ratio = 0.304, P = .014) and knee

  15. Detection of immunoglobulins containing plasma cells in the thymus, bursa of Fabricius and spleen of vaccinated broiler chickens with Newcastle disease virus vaccine

    OpenAIRE

    Masum, Md. Abdul; Khan, Mohammed Zahirul Islam; Nasrin, Morsheda; Siddiqi, M. Nazmul Hassan; Khan, Mohammed Zubayer Ibna; Islam, Md. Nabiul

    2014-01-01

    Mobilization of immunoglobulins (Igs)-containing plasma cells (IgA, IgG and IgM) in the spleen, bursa of Fabricius and thymus was investigated in broiler chickens that were vaccinated with Newcastle disease virus (NDV) vaccine. In the thymus, the Igs-containing plasma cells were distributed in the cortex and medulla. Their frequency and distribution were higher at D14 and at D28. The number of IgG- and IgM-positive cells was greater than IgA-positive cells in thymus. In the bursa of Fabricius...

  16. Distribution of the axillary nerve to the subacromial bursa and the area around the long head of the biceps tendon.

    Science.gov (United States)

    Nasu, H; Nimura, A; Yamaguchi, K; Akita, K

    2015-09-01

    Patients with a shoulder disorder often complain of pain on the anterior or lateral aspect of the shoulder. Such pain has been thought to originate from the suprascapular nerve. However, taking into consideration the distinctive course of the axillary nerve, the axillary nerve is likely to supply branches to the structure around the shoulder joint. This study was conducted to clarify the division, course, and distribution of the branches which originate from the axillary nerve and innervate structures around the shoulder joint. The division, course, and distribution of the branches which originate from the axillary nerve and innervate structures around the shoulder joint were examined macroscopically by dissecting 20 shoulders of 10 adult Japanese cadavers. The thin branches from the anterior branch of the axillary nerve were distributed to the subacromial bursa and the area around the long head of the biceps tendon. The branches from the main trunk of the axillary nerve or the branch to the teres minor muscle were distributed to the infero-posterior part of the shoulder joint. The pain on the anterior or lateral aspect of the shoulder, which has been thought to originate from the suprascapular nerve, might be related to the thin branches which originate from the axillary nerve and innervate the subacromial bursa and the area around the long head of the biceps tendon. These results would be useful to consider the cause of the shoulder pain or to prevent the residual pain after the biceps tenodesis.

  17. Involvement of the inconstant bursa of the fifth metatarsophalangeal joint in psoriatic arthritis: a clinical and ultrasonographic study.

    Science.gov (United States)

    Ciancio, Giovanni; Volpinari, Stefania; Fotinidi, Maria; Furini, Federica; Farina, Ilaria; Bortoluzzi, Alessandra; Ferracin, Manuela; Bandinelli, Francesca; Orzincolo, Carlo; Trotta, Francesco; Govoni, Marcello

    2014-01-01

    To evaluate the involvement of the bursa located next to the head of the 5th metatarsal bone in patients with psoriatic arthritis (PsA) in comparison with the other seronegative spondyloarthritis (SpA). All patients with PsA seen during a period of 24 months were enrolled. The control group included healthy subjects and patients with the other SpA. All subjects underwent clinical and ultrasound (US) examination of the lateral surface of the 5th metatarsal. 150 PsA patients (88 M; 62 F), 172 SpA (107 M; 65 F), and 95 healthy controls (58 M; 37 F) were evaluated. Based on clinical and US evaluation, bursitis was diagnosed in 17/150 (11.3%) PsA patients but in none of the SpA (P bursa of the 5th metatarsophalangeal joint appears to be involved in PsA more frequently than by chance. If confirmed by other studies, this finding could be considered as a distinctive clinical sign of PsA, useful for differential diagnosis with the other SpA. In asymptomatic patients, US proved to be more sensitive in the detection of bursitis.

  18. Influence of sex, age, and fasting on blood parameters and body, bursa, spleen and yolk sac weights of broiler chicks

    Directory of Open Access Journals (Sweden)

    DL Pires

    2007-12-01

    Full Text Available The effects of water and feed fasting for 24, 48 and 72 hours post-hatching on blood parameters (mean corpuscular volume, MCV; red blood-cell, RBC; hematocrit, HCT; hemoglobin, HGB; plasma glucose, CGP; plasma total protein, PP, and differential leukocytes count, and on body, liver, spleen, bursa, and yolk sac weights were analyzed. Erythrogram data were obtained with a blood cell counter. Total plasma protein and plasma glucose were determined by using the Bradford method (1976 and a glucose PAP liquiform kit (Labtest, cat. n. 84, respectively. Specific leukocyte counts were carried out on blood smears stained with Rosenfeld solution. According to the obtained data, water and feed post-hatching fasting reduced MCV values, which also were lower in males than that in females. Fasting for 48 hours promoted an increase in PP, while fasting for 72 hours reduced HCT. Chicks submitted to fasting presented lower body weights as compared to fed chicks, but their liver weight did not increase between 48 and 72 hours of age. Fasting decreased spleen weight, but bursa and yolk sac weight were not affected. Data showed that female and male chicks react in a similar way to post-hatching fasting, which affects body weight, liver and spleen weight, and HCT and PP values. Moreover, 72 hours of fasting affected more intensely HCT and MCV values.

  19. WORK AND ORGANIZATION IN THE OTTOMAN EMPIRE: NOTES ON THE TRADE GUILDS OF SIXTEENTH- AND SEVENTEENTH CENTURY BURSA

    Directory of Open Access Journals (Sweden)

    Dr. Ömer DÜZBAKAR

    2008-09-01

    Full Text Available The primary function of artisans’ and commercial guilds was toperform and maintain daily activities of economic life in harmony andsocial consolidation with minimal conflict. Thus, the state would get ridof the heavy burden of bureaucratic procedures on the one hand, and yetwould also have the guilds yield to a standard of production as well aseliminate unfair competition through their autonomous internal workingson the other. Through such an auto-control mechanism the guilds wouldsolve their own problems with minimum resort to administrative andjudicial institutions. This article sheds light on the origins of Ottomanguild system, workings of trade guilds of Bursa and the supervisoryfunctions of their managers as well as on the various roles and activitiesplayed by the guilds in imperial public life. It also examines the conflictsof interest, unruly acts and forms of resolution taking place within andacross the guilds, with or without having recourse to judicial and otherimperial authorities. The study is based on a set of original historical documents surveyed from the Shari’a Court records of Bursa in the 16thand 17th centuries.

  20. Retrieval of Green's Functions from Ambient Noise Measurements in the Adana and Bursa Basins of Turkey

    Science.gov (United States)

    Bakirci, Taciser; Kaslilar, Ayse; Kocaoglu, Argun

    2014-05-01

    Records of ambient seismic noise (ASN) field are widely used to obtain seismic velocity structures at both engineering and global scales. Two well-known methods commonly employed to obtain shear-wave velocity profiles, in engineering seismology, are the frequency-wavenumber (FK) transform and spatial auto-correlation (SPAC) methods that are based on the analysis of ASN field recorded by 2D sensor arrays. At global scale on the other hand, seismic velocity structure is determined by the Green's function retrieved from cross-correlation of the ASN recorded between two seismic stations. In the last decade, this approach has become complementary or almost alternative to the conventional methods of surface wave tomography used to investigate the velocity structure of the crust and upper mantle. Similarly, in recent years, the Green's functions estimated from ASN have also been used to investigate the shear-wave velocity structure of basins and their site amplification properties. This work presents the Rayleigh wave Green's functions retrieved from the vertical-component ASN data recorded in the Bursa and Adana basins of Turkey. This constitutes the first stage of our research whose objective is to investigate whether velocity structures of these basins can reliably be obtained from tomographic inversion. The continuous data used in our study were recorded between 2010 and 2013 by the national seismic networks operated by Kandilli Observatory and Earthquake Research Institute (KOERI) of Bosphorus University and Earthquake Research Department (ERD) of Disaster and Emergency Management Presidency of Turkey. For both basins, distances between station pairs are in the range of 30-200 km. In this distance range, the Green's functions reveal Rayleigh waves with the periods of 6 to 30 s. Group velocity dispersion analysis carried out by the multiple filtering technique show that the group velocities are estimated to be in the range of 2.5-4.0 km/s. Observed variation of group

  1. Relative quantification and detection of different types of infectious bursal disease virus in bursa of Fabricius and cloacal swabs using real time RT-PCR SYBR green technology

    DEFF Research Database (Denmark)

    Li, Yiping; Handberg, K.J.; Kabell, Susanne

    2007-01-01

    In present study, different types of infectious bursal disease virus (IBDV), virulent strain DK01, classic strain F52/70 and vaccine strain D78 were quantified and detected in infected bursa of Fabricius (BF) and cloacal swabs using quantitative real time RT-PCR with SYBR green dye. For selection...

  2. A Study on Evaluation of the Biology Projects Submitted to the TUBITAK Secondary Education Research Projects Contest from the Bursa Region

    Science.gov (United States)

    Zeren Özer, Dilek; Güngör, Sema Nur; Özkan, Muhlis

    2015-01-01

    This study evaluates, through the employment of scientific methods and techniques, a total of 107 Biology projects submitted by secondary education students to the Bursa Region Coordinatorship of TUBITAK (a region which encompasses the municipalities of Afyonkarahisar, Balikesir, Bilecik, Canakkale, Eskisehir, Kutahya, and Yalova). The projects…

  3. Obturator externus bursa: prevalence of communication with the hip joint and associated intra-articular findings in 200 consecutive hip MR arthrograms.

    Science.gov (United States)

    Kassarjian, Ara; Llopis, Eva; Schwartz, Richard B; Bencardino, Jenny T

    2009-11-01

    The purpose of the study was to demonstrate the prevalence of communication between the hip joint and the obturator externus bursa on hip MR arthrography. Following institutional review board approval, 200 hip MR arthrograms in 196 subjects were independently reviewed by two musculoskeletal radiologists. Discrepancies were resolved by adjudication. The presence or absence of communication between the hip joint and the obturator externus bursa was recorded. Associated lesions involving the acetabular labrum and articular cartilage were recorded. The obturator externus bursa was shown to communicate with the hip joint in 11 of the 200 (5.5%) hip MR arthrograms. Of these, six were in men and five were in women. The age range was 15-63 years with a mean age of 34 years. All 11 patients had labral tears. Eight of the 11 had cartilage lesions. The obturator externus bursa can be seen to communicate with the hip joint in 5.5% of hip MR arthrograms. Associated labral and cartilage lesions are common.

  4. Surgical anatomy of the omental bursa and the stomach based on a minimally invasive approach : Different approaches and technical steps to resection and lymphadenectomy

    NARCIS (Netherlands)

    Brenkman, Hylke J.F.; van der Wielen, Nicole I.; Ruurda, Jelle P.; van Leeuwen, Maarten S.; Scheepers, Joris J.G.; van der Peet, Donald L; van Hillegersberg, Richard; Bleys, Ronald L.A.W.; Cuesta, Miguel A.

    2017-01-01

    Background: It is imperative for surgeons to have a proper knowledge of the omental bursa in order to perform an adequate dissection during minimally invasive surgery (MIS) of the upper gastrointestinal (GI) tract. This study aimed to describe (1) the various approaches which can be used to enter

  5. PENGARUH PENGGUNAAN TRENDLINE DAN FIBONACCI RETRACEMENT TERHADAP PENGAMBILAN KEPUTUSAN JUAL/BELI FOREIGN EXCHANGE PAIR EUR/USD PADA PERUSAHAAN BERJANGKA YANG TERDAFTAR DI BURSA BERJANGKA JAKARTA (BBJ)

    OpenAIRE

    PASAPAN, FRANS

    2017-01-01

    2017 ABSTRAK Pengaruh Penggunaan Trendline Dan Fibonacci Retracement terhadap Pengambilan Keputusan Jual/Beli Foreign Exchange Pair Eur/Usd pada Perusahaan Berjangka yang Terdaftar Di Bursa Berjangka Jakarta (BBJ) Frans Pasapan Cepi Pahlevi Kasman Damang Penelitian ini bertujuan untuk menganalisis penggunaan alat-alat perdagangan dalam MetaTrader 4 yang mempengaruhi pengambilan keputusan jual/beli pair EUR/US...

  6. Concurrent Fowlpox and Candidiasis Diseases in Backyard Chickens with Unusual Pox Lesions in the Bursa of Fabricius.

    Science.gov (United States)

    Ogasawara, Fusae; Yamamoto, Yu; Sato, Yasuo; Fukunari, Kazuhiro; Murata, Ken-Ichi; Yaegashi, Gakuji; Goto, Makiko; Murakami, Ryukoh

    2016-09-01

    Concurrent fowlpox and candidiasis diseases occurred in a backyard chicken flock. Four deceased chickens (one Nagoya breed and three white silkie chickens) were examined for diagnosis. At necropsy, white curd-like plaques were observed in the crop. Fungal elements that stained positive for Candida albicans with immunohistochemistry were distributed throughout the tongue, choanal mucosa, esophagus, and crop. Typical fowlpox lesions, composed of proliferating epithelial cells with ballooning degeneration and viral intracytoplasmic inclusions, were observed in the conjunctiva, nasal mucosa, and skin around the cloaca. Interestingly, hyperplastic interfollicular epithelium with rare virus inclusions was observed in the bursa of Fabricius (BF). Some bursal follicles were replaced by proliferating epithelial cells. These proliferating cells immunohistochemically stained positive for cytokeratin. PCR and subsequent genetic sequencing detected the C. albicans gene in the crop, and fowlpox virus genes in the BF. These results indicate that this outbreak was a rare presentation of fowlpox in spontaneously infected chickens, with unusual pox lesions in the BF.

  7. Enrichment and verification of differentially expressed miRNAs in bursa of Fabricius in two breeds of duck

    Directory of Open Access Journals (Sweden)

    Jun Luo

    2017-07-01

    Full Text Available Objective The bursa of Fabricius (BF is a central humoral immune organ belonging specifically to avians. Recent studies had suggested that miRNAs were active regulators involved in the immune processes. This study was to investigate the possible differences of the BF at miRNA level between two genetically disparate duck breeds. Methods Using Illumina next-generation sequencing, the miRNAs libraries of ducks were established. Results The results showed that there were 66 differentially expressed miRNAs and 28 novel miRNAs in bursa. A set of abundant miRNAs (i.e., let-7, miR-146a-5p, miR-21-5p, miR-17~92 which are involved in immunity and disease were detected and the predicted target genes of the novel miRNAs were associated with duck high anti-adversity ability. By gene ontology analysis and enriching KEGG pathway, the targets of differential expressed miRNAs were mainly involved in immunity and disease, supporting that there were differences in the BF immune functions between the two duck breeds. In addition, the metabolic pathway had the maximum enriched target genes and some enriched pathways that were related to cell cycle, protein synthesis, cell proliferation and apoptosis. It indicted that the difference of metabolism may be one of the reasons leading the immune difference between the BF of two duck breeds. Conclusion This data lists the main differences in the BF at miRNAs level between two genetically disparate duck breeds and lays a foundation to carry out molecular assisted breeding of poultry in the future.

  8. 30 Years Retrospective Review of Tuberculosis Cases in a Tuberculosis Dispensary in Bursa/Nilufer, Turkey (1985-2014

    Directory of Open Access Journals (Sweden)

    Kayıhan PALA

    2016-11-01

    Full Text Available Abstract Objective: The aim of this study was to evaluate tuberculosis control programmes of patients who applied to the Bursa Nilufer Tuberculosis Dispensary and by investigating the changes in the variables over 3 decades. Method: In this retrospective descriptive study, the records of all tuberculosis cases (1662 people treated in the last 30 years (1985-2014 at the Bursa Nilufer Tuberculosis Dispensary were examined. In the analysis, the chi-square test, the trend chi-square test and Fisher's exact test were used. Results: Males comprised 65.2% of the patients. The ages of the patients ranged from 1 to 87 years, and the mean age was 37.4 (95% CI:36.6-38.2. Among the cases, 86.7% were new and 74.1% were pulmonary tuberculosis. In the last decade, the proportion of women, the education level, the proportion of patients who had received a BCG vaccination and the proportion of active employees among women increased by a statistically significant amount, while the proportion of employees among men decreased. Clinical symptoms, such as weakness, anorexia, weight loss, and cough, decreased to a statistically significant degree. In the last decade, the mortality rate was 3.6%, a statistically significant increase compared with previous decades. Mortality was statistically significant higher among patients who were elderly, male, did not have a BCG scar or had a chronic disease. Conclusion: This study reveals the need for studies that determine the risk factors associated with tuberculosis mortality and examine the effectiveness of tuberculosis control programmes. Direct measures to address mortality risk factors can reduce the number of deaths from tuberculosis.

  9. Injection of the subacromial bursa in patients with rotator cuff syndrome: a prospective, randomized study comparing the effectiveness of different routes.

    Science.gov (United States)

    Marder, Richard A; Kim, Sunny H; Labson, Jerry D; Hunter, John C

    2012-08-15

    Rotator cuff syndrome is often treated with subacromial injection of corticosteroid and local anesthetic. It has not been established if the common injection routes of the bursa are equally accurate. We conducted a prospective clinical trial involving seventy-five shoulders in seventy-five patients who were randomly assigned to receive a subacromial injection through an anterior, lateral, or posterior route with respect to the acromion. An experienced physician performed the injections, which contained radiopaque contrast medium, corticosteroid, and local anesthetic. After the injection, a musculoskeletal radiologist, blinded to the injection route, interpreted all of the radiographs. The rate of accuracy varied with the route of injection, with a rate of 56% for the posterior route, 84% for the anterior route, and 92% for the lateral route (p = 0.006; chi-square test). The accuracy of injection through the posterior route was significantly lower than that through either the anterior or the lateral route (p bursa in females.

  10. Methicillin-resistant Staphylococcus aureus infection of the subacromial bursa: an unusual complication following subacromial corticosteroid injection (a report of two cases).

    Science.gov (United States)

    Teoh, Kar H; Jones, Sian A; Gurunaidu, Subramaniam; Pritchard, Mark G

    2015-07-01

    Subacromial corticosteroid injections are frequently used for both diagnostic and therapeutic purposes in shoulder pain. Subacromial septic bursitis is a recognized but rare complication. There have been no reports of methicillin-resistant Staphylococcus aureus infections of the subacromial bursa after subacromial injections in the literature. We describe case reports of two patients who presented with subacromial methicillin-resistant Staphylococcus aureus septic bursitis following subacromial corticosteroid injections in the community and highlight the diagnostic and management challenges of this condition.

  11. Methicillin-resistant Staphylococcus aureus infection of the subacromial bursa: an unusual complication following subacromial corticosteroid injection (a report of two cases)

    OpenAIRE

    Teoh, Kar. H.; Jones, Sian A; Gurunaidu, Subramaniam; Pritchard, Mark G.

    2014-01-01

    Subacromial corticosteroid injections are frequently used for both diagnostic and therapeutic purposes in shoulder pain. Subacromial septic bursitis is a recognized but rare complication. There have been no reports of methicillin-resistant Staphylococcus aureus infections of the subacromial bursa after subacromial injections in the literature. We describe case reports of two patients who presented with subacromial methicillin-resistant Staphylococcus aureus septic bursitis following subacromi...

  12. Microtremor exploration for shallow S-wave velocity profiles at stations in local strong motion network in Bursa, Yalova, and Kocaeli in north-western Turkey

    Science.gov (United States)

    Özmen, Özgür Tuna; Yamanaka, Hiroaki; Chimoto, Kosuke; Çeken, Ulubey; Alkan, Mehmet Akif; Tekin, Kudret; Ateş, Erkan

    2017-05-01

    We conducted microtremor array surveys for shallow S-wave velocity profiles at 20 sites in Bursa, Yalova and Kocaeli provinces in the north-western part of Turkey to provide fundamental data to assess the seismic hazard in the area. All of the measurement sites were positioned very close to strong motion stations belonging to the Disaster and Emergency Management Presidency of Turkey (AFAD) in order to further understand site amplification factors in strong motion records. Of the 20 study sites, two were located in Yalova, four in Bursa and 14 in Kocaeli. We temporarily installed two small arrays to obtain simultaneous records of vertical microtremors. Then, the spatial autocorrelation method was applied to retrieve Rayleigh wave phase velocity curves in a frequency range from 1 to 30 Hz from the array records. The phase velocities in the western part of the Kocaeli area are low across a wide frequency range, while relatively high phase velocities are found in the eastern part of the Kocaeli province. The phase velocities in the Yalova and Bursa provinces are widely distributed suggesting large variations in soil conditions. The observed phase velocity curve at each site was inverted to a one-dimensional (1D) S-wave velocity profile to a depth of 100 m, using a hybrid heuristic inversion method. All the S-wave velocity profiles in the eastern Kocaeli area are similar; however, the sites in the western Kocaeli and Yalova-Bursa areas have profiles with different features from the others. Finally, we discuss amplification factors for S-waves using the inverted profiles. The dominant fundamental periods of the amplification factors were distributed in a frequency range from 0.7 to 5 Hz. The profiles obtained are also used to map average S-wave velocities in the study area, with an addition of existing data at strong motion stations of the AFAD.

  13. PENGARUH FIFA WORLD CUP PADA RETURN PASAR DI BURSA EFEK INDONESIA, MALAYSIA, TIONGKOK, KOREA SELATAN, DAN JEPANG PERIODE TAHUN 2002, 2006, 2010, 2014

    OpenAIRE

    Rusdianto, Yanuar

    2016-01-01

    Penelitian ini bertujuan untuk menguji pengaruh FIFA World Cup pada return pasar di Bursa Efek Indonesia, Malaysia, Tiongkok, Korea Selatan, dan Jepang periode tahun 2002, 2006, 2010, 2014. Peristiwa Piala Dunia merupakan salah satu anomali pasar yang dapat dimanfaatkan untuk mendapatkan abnormal return. Dalam penelitian ini, data yang digunakan merupakan data harian satu tahun indeks pasar dimana tahun tersebut terdapat event Piala Dunia. Data sekunder tersebut merupakan harga adjusted close...

  14. PENGARUH ANALISIS RASIO KEUANGAN TERHADAP KEBIJAKAN DEVIDEN (Studi Empiris pada Perusahaan Real Estate dan Property yang Terdaftar di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Wiwin Siswantini

    2015-01-01

    Full Text Available The purpose of this study was to analyze the effect of financial ratios to dividend policy. Research conducted on the real estate and property companies listed in Indonesia Stock Exchange. Sampling was conducted using purposive sampling and determined 47 companies in the sample. The data used was the data of 2009 to 2011. The analytical method was used multiple linear regression analysis. Based on the analysis it can be concluded that the return on investment, debt to total assets, and earnings per share significantly influence the dividend payout ratio in real estate and property companies in Indonesia Stock Exchange. The total asset turnover found no effect on the dividend payout ratio. The implication of this research is to increase the dividend payout ratio, real estate and property companies in Indonesia Stock Exchange should pay more attention to return on investment, debt to total assets and earnings per share. To maximaze corporate profit, Real estate and property companies in Indonesia Stock Exchange should be more efficiency using its asset. Artikel ini menganalisis pengaruh rasio keuangan terhadap kebijakan deviden dan merupakan hasil penelitian yang telah dilakukan terhadap perusahaan real estate dan properti yang terdaftar di Bursa Efek Indonesia. Penarikan sampel dilakukan dengan metode purposive sampling dan ditentukan 47 perusahaan sebagai sampel. Data yang digunakan adalah data tahun 2009 sampai dengan tahun 2011. Metode analisis yang digunakan adalah analisis regresi linier berganda. Berdasarkan hasil analisis dapat disimpulkan bahwa Return on investment, Debt to total assets, dan Earning per share berpengaruh signifikan terhadap dividend payout ratio pada perusahaan real estate dan properti di Bursa Efek Indonesia. Total asset turnover ditemukan tidak berpengaruh terhadap dividend payout ratio. Implikasi dari penelitian ini adalah untuk meningkatkan dividend payout ratio, perusahaan real estate dan property di Bursa Efek

  15. SALINE ARTHROGRAPHY OF THE DISTAL INTERPHALANGEAL JOINT FOR LOW-FIELD MAGNETIC RESONANCE IMAGING OF THE EQUINE PODOTROCHLEAR BURSA: FEASIBILITY STUDY.

    Science.gov (United States)

    McGill, Shannon L; Gutierrez-Nibeyro, Santiago D; Schaeffer, David J; Hartman, Susan K; O'Brien, Robert T; Joslyn, Stephen K

    2015-01-01

    Abnormalities of the deep digital flexor tendon, navicular bone, and collateral sesamoidean ligament can be difficult to visualize using magnetic resonance imaging (MRI) if bursal fluid is absent. The use of saline podotrochlear bursography improves podotrochlear apparatus evaluation, however, the technique has disadvantages. The objective of this prospective feasibility study was to describe saline arthrography of the distal interphalangeal joint as an alternative technique for improving MRI visualization of the deep digital flexor tendon, navicular bone, collateral sesamoidean ligament, and podotrochlear bursa, and to compare this technique with saline podotrochlear bursography. Eight paired cadaver forelimbs were sampled. Saline podotrochlear bursography or saline arthrography techniques were randomly assigned to one limb, with the alternate technique performed on the contralateral limb. For precontrast and postcontrast studies using each technique, independent observers scored visualization of the dorsal aspect of the deep digital flexor tendon, palmar aspect of the navicular bone, collateral sesamoidean ligament, and podotrochlear bursa. Both contrast techniques improved visualization of structures over precontrast MR images and visualization scores for both techniques were similar. Findings from this study demonstrated that saline arthrography is feasible and comparable to saline podotrochlear bursography for producing podotrochlear bursa distension and separation of the structures of the podotrochlear apparatus on nonweight bearing limbs evaluated with low-field MRI. Clinical evaluation of saline arthrography on live animals is needed to determine if this technique is safe and effective as an alternative to saline podotrochlear bursography in horses with suspected pathology of the podotrochlear apparatus. © 2015 American College of Veterinary Radiology.

  16. Detection of immunoglobulins containing plasma cells in the thymus, bursa of Fabricius and spleen of vaccinated broiler chickens with Newcastle disease virus vaccine

    Directory of Open Access Journals (Sweden)

    Md. Abdul Masum

    2014-12-01

    Full Text Available Mobilization of immunoglobulins (Igs-containing plasma cells (IgA, IgG and IgM in the spleen, bursa of Fabricius and thymus was investigated in broiler chickens that were vaccinated with Newcastle disease virus (NDV vaccine. In the thymus, the Igs-containing plasma cells were distributed in the cortex and medulla. Their frequency and distribution were higher at D14 and at D28. The number of IgG- and IgM-positive cells was greater than IgA-positive cells in thymus. In the bursa of Fabricius, Igs-containing plasma cells were distributed beneath the capsules; within and around the bursal follicles. Their frequency of occurrence significantly peaked at D14 and at D28 in comparison to day-old chickens, and IgG-positive cells were significantly greater than the IgA- and IgM-positive cells in the bursa of vaccinated chickens. In the spleen, Igs-containing plasma cells were distributed in the white pulp, around the trabeculae, and in the periarterial lymphatic sheath. In this secondary lymphatic tissue, IgG- and IgM-positive cell numbers significantly greater than IgA-positive cells. In conclusion, mobilization of more Igs-positive cells in lymphoid tissues of broiler chickens is due to the effect of NDV vaccine as well as the advancement of age.

  17. REAKSI PASAR MODAL TERHADAP PELAPORAN SELISIH KURS PERSPEKTIF FOREIGN CURRENCY FORWARD EXCHANGE-IFRS (STUDI EMPIRIS DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    R. Anastasia Endang Susilawati

    2011-02-01

    Full Text Available Penelitian ini bertujuan memberikan bukti empiris mengenai pelaporan selisih kurs terhadap reaksi pasar modal dengan menggunakan return saham sebagai proxy. Sampel penelitian diperoleh 31 perusahaan dari Bursa Efek Indonesia pada periode pengamatan antara tahun 2007-2010 menggunakan metode purposive sampling. Temuan penelitian ini mendukung hipotesis satu dan hipotesis dua bahwa terdapat hubungan signifikan antara pelaporan rugi selisih kurs yang diakui sebagai pendapatan/biaya dengan return saham. Return saham tidak berkorelasi secara signifikan dengan perubahan pendapatan bersih atau revenue. Return saham berkorelasi negatif dan signifikan dengan perubahan cash flow dibagi dengan total assets. Return saham tidak berkorelasi secara signifikan dengan pelaporan rugi selisih kurs. Dari uji beda, investor merespon tidak berbeda dengan melihat return saham terhadap dua metode pelaporan akuntansi atas laba/rugi selisih kurs yaitu yang mengakui sebagai pendapatan/biaya dan yang mengkapitalisasi laba/rugi selisih kurs tersebut. Penelitian selanjutnya diharapkan memasukkan perusahaan yang mengkapitalisasi laba/rugi selisih kurs sebagian pada seluruh jenis industri dan membandingkan ketiga metode pelaporan selisih kurs 

  18. Atmospheric concentrations of PAHs, their possible sources and gas-to-particle partitioning at a residential site of Bursa, Turkey

    Science.gov (United States)

    Esen, Fatma; Tasdemir, Yücel; Vardar, Nedim

    Atmospheric PAH concentrations were determined in Gulbahce district of Bursa, Turkey between August 2004 and April 2005. Measured PAH concentrations were classified as heating and non-heating season samples. The concentrations of total PAHs in heating season were almost ten times higher than those in non-heating season. Diagnostic ratios and factor analysis results show that in the heating season traffic along with residential heating emissions heavily influence PAH concentrations. The plot of log Kp versus log PL0 for all the data set of heating and non-heating season samples gave significantly different slopes. The slope for the heating season samples (- 0.92) was steeper than the one for the non-heating season samples (- 0.78). The partitioning results for individual samples further indicated that slope values varied depending on air parcel trajectories. Air parcels traveled over water (either over the Black Sea or Aegean Sea) prior to arriving at the sampling site had less steep slopes. Partitioning of PAHs was also investigated by comparing experimentally determined Kp values with the results obtained both from octanol-based model ( Kp(Oct.)) and soot and octanol-based model ( Kp (Soot + Oct.)). Both models were useful in predicting the experimental Kp values. However, they did not explain the observed variability in the experimental Kp values.

  19. L-lactate dehydrogenase from leaves of Capsella bursa-pastoris (L.) Med. : I. Identification and partial characterization.

    Science.gov (United States)

    Betsche, T; Bosbach, K; Gerhardt, B

    1979-10-01

    By ammonium sulfate fractionation and gel filtration an enzyme preparation which catalyzed NAD(+)-dependent L-lactate oxidation (10(-4) kat kg(-1) protein), as well as NADH-dependent pyruvate reduction (10(-3) kat kg(-1) protein), was obtained from leaves of Capsella bursa-pastoris. This lactate dehydrogenase activity was not due to an unspecific activity of either glycolate oxidase, glycolate dehydrogenase, hydroxypyruvate reductase, alcohol dehydrogenase, or a malate oxidizing enzyme. These enzymes could be separated from the protein displaying lactate dehydrogenase activity by gel filtration and electrophoresis and distinguished from it by their known properties. The enzyme under consideration does not oxidize D-lactate, and reduces pyruvate to L-lactate (the configuration of which was determined using highly specific animal L-lactate dehydrogenase). Based on these results the studied Capsella leaf enzyme is classified as L-lactate dehydrogenase (EC 1.1.1.27). It has a Km value of 0.25 mmol l(-1) (pH 7.0, 0.3 mmol l(-1) NADH) for pyruvate and of 13 mmol l(-1) (pH 7.8, 3 mmol l(-1) NAD(+)) for L-lactate. Lactate dehydrogenase activity was also detected in the leaves of several other plants.

  20. Estimation of soil erosion risk within an important agricultural sub-watershed in Bursa, Turkey, in relation to rapid urbanization.

    Science.gov (United States)

    Ozsoy, Gokhan; Aksoy, Ertugrul

    2015-07-01

    This paper integrates the Revised Universal Soil Loss Equation (RUSLE) with a GIS model to investigate the spatial distribution of annual soil loss and identify areas of soil erosion risk in the Uluabat sub-watershed, an important agricultural site in Bursa Province, Turkey. The total soil loss from water erosion was 473,274 Mg year(-1). Accordingly, 60.3% of the surveyed area was classified into a very low erosion risk class while 25.7% was found to be in high and severe erosion risk classes. Soil loss had a close relationship with land use and topography. The most severe erosion risk typically occurs on ridges and steep slopes where agriculture, degraded forest, and shrubs are the main land uses and cover types. Another goal of this study was to use GIS to reveal the multi-year urbanization status caused by rapid urbanization that constitutes another soil erosion risk in this area. Urbanization has increased by 57.7% and the most areal change was determined in class I lands at a rate of 80% over 25 years. Urbanization was identified as one of the causes of excessive soil loss in the study area.

  1. Biliopancreatic fistula and abscess formation in the bursa omentalis associated with intraductal papillary mucinous cancer of the pancreas.

    Science.gov (United States)

    Nagano, Hideki; Koneri, Kenji; Honda, Kei; Murakami, Makoto; Hirono, Yasuo; Maeda, Hiroyuki; Goi, Takanori; Iida, Atsushi; Katayama, Kanji; Yamaguchi, Akio

    2009-10-01

    We describe an unusual case of biliopancreatic fistula, free perforation, and subsequent abscess formation within the lesser peritoneal sac associated with intraductal papillary mucinous carcinoma (IPMC). A 71-year-old man presented with general fatigue and loss of appetite that had persisted for 1 month. Abdominal computed tomography (CT) revealed findings consistent with an intraductal papillary mucinous neoplasm (IPMN) of the pancreas, accompanied by abscess formation in the bursa omentalis. Gastrointestinal fiberscopy revealed a swollen papilla of Vater expanded by sticky mucus, and a communication between the pancreatic duct and bile duct was demonstrated by the injection of indigo carmine solution into the pancreatic duct. Percutaneous transhepatic abscess drainage (PTAD) was performed on the day of admission. After this procedure, the patient was managed for 1 month and supported nutritionally with glycemic control for diabetes mellitus. After admission, the patient had an episode of obstructive jaundice that was treated by retrograde biliary drainage. Pancreaticoduodenectomy with lymph node dissection was then performed. Pathological examination revealed IPMN with patchy, scattered carcinoma of the pancreatic head and uncinate process with the formation of a biliopancreatic fistula. Bile duct epithelium in the area of the biliopancreatic fistula demonstrated atypical papillary epithelium suggestive of tumor invasion.

  2. Electron microscopic study on the development of Babesia ovis (Piroplasmia) in the salivary glands of the vector tick Rhipicephalus bursa.

    Science.gov (United States)

    Moltmann, U G; Mehlhorn, H; Friedhoff, K T

    1982-03-01

    The formation of Babesia ovis sporozoites in salivary gland cells of the vector tick Rhipicephalus bursa was studied by electron microscopy. The kinetics of B. ovis were found lying intracellularly on the second day after infestation (a.i.) of the ticks. The parasites enlarged rapidly losing all features of the motile form. Invaginations of the cell membrane initiated a fragmentation of this developmental stage. On the third day a.i the parasite (measuring 40 x 25 microns) was divided into numerous single membrane-bounded cytomeres, each provided with at least one lobed nucleus. On the fourth day a.i. sporozoite differentiation started at the periphery of the cytomeres, indicated by the appearance of several pellicle-bounded, exogenous protrusions into each of which a small portion of the nucleus was incorporated. Since the cytomeres lay very close together this differentiation occurred more by segmentation than by budding. Rhoptries and the so-called spherical body appeared in this developmental phase. Finally, the isolated, immature sporozoites lay in a granular matrix which contained remnants of the host cell cytoplasm. On the fifth day a.i. the sporozoites were fully developed, typically pear-shaped (2.8 x 1.2 microns) and provided with all characteristic structures of the invasive form.--This reproduction was compared to similar processes in other species of the Piroplasmia and the Haemosporina.

  3. KOINTEGRASI BURSA-BURSA SAHAM DI ASIA

    Directory of Open Access Journals (Sweden)

    Riko Hendrawan

    2017-03-01

    Full Text Available One important indicator of capital market development could be seen from the value of the composite stockprice index. Composite stock price index reflected the performance of all shares registered in particular country.The objective of this research was to know whether there was co integration or long-term equilibriumamong Indonesia, Malaysia, Singapore, Thailand, Philippines, Hongkong, Japan, South Korea and China,either in groups or in pairs using the method of co-integration during January 2000 - January 2010. Theresults of this research using Johansen Co-Integration test indicated that there was long-term equilibriumamong Indonesia, Malaysia, Singapore, Thailand, Philippines, Hongkong, Japan, South Korea and China inthe period of January 2000 - January 2010, in groups and in pairs. The results showed that the South Koreastock market was the most influential to the Indonesian stock markets, and China’s stock market was the mostdominant stock market among these countries during January 2000 - January 2010.

  4. Ocorrência de Ornithonyssus bursa (Berlese, 1888 (Acari: Macronyssidae em filhotes de Megascops choliba (corujinha-do-mato e Pitangus sulphuratus (bem-te-vi, no Rio Grande do Sul, Brasil Ocurrence of Ornithonyssus bursa (Berlese, 1888 (Acari: Macronyssidae on Megascops choliba (tropical screech-owl and Pitangus sulphuratus (great kiskadee nestlings in the Rio Grande do Sul State, Brazil

    Directory of Open Access Journals (Sweden)

    Carolina S. Mascarenhas

    2009-12-01

    Full Text Available O Núcleo de Reabilitação da Fauna Silvestre e Centro de Triagem de Animais Silvestres da Universidade Federal de Pelotas - RS atendeu dois filhotes de Megascops choliba (corujinha-do-mato (Strigiformes - Strigidae e dois de Pitangus sulphuratus (bem-te-vi (Passeriformes - Tyrannidae intensamente parasitados por ácaros, em maio de 2005 e dezembro de 2006, respectivamente. Os filhotes e o ninho de P. sulphuratus foram recolhidos na zona urbana da cidade de Pelotas - RS após forte temporal. Os ácaros foram removidos, colocados em álcool 70% e levados ao laboratório de parasitologia para identificação. Os espécimes foram clarificados em lactofenol, montados em meio de Hoyer e identificados como Ornithonyssus bursa (Acari - Macronyssidae. Registra-se Megascops choliba e Pitangus sulphuratus como hospedeiros de Ornithonyssus bursa, no Rio Grande do Sul, Brasil.The Center for Rehabilitation of Wildlife and Center for Selection of Wild Animal of the Federal University of Pelotas has attended two nestlings of Megascops choliba (tropical screech-owl (Strigiformes - Strigidae and two of Pitangus sulphuratus (great kiskadee (Passeriformes - Tyrannidae heavily parasitized by mites, in May 2005 and December 2006, respectively. The nestlings and the nest of P. sulphuratus were collected in the Pelotas urban area after severe storms. The mites were removed, clarified in lactofenol, permanently mounted in Hoyer's medium and identified as Ornithonyssus bursa (Acari - Macronyssidae. Megascops choliba and Pitangus sulphuratus are reported as host of Ornithonyssus bursa in Rio Grande do Sul State, Brazil.

  5. The relationship between subacromial bursa thickness on ultrasound and shoulder pain in open water endurance swimmers over time.

    Science.gov (United States)

    Couanis, G; Breidahl, W; Burnham, S

    2015-07-01

    To help clinicians understand the clinical relevance of subacromial bursa (SAB) thickness on ultrasound investigations in marathon swimmers. A prospective, observational cohort study. Twenty two open-water marathon swimmers entered in a 19.7km open-water event received comprehensive, bilateral, shoulder ultrasounds on three occasions: 4 months prior to the race, 2 weeks prior to the race and within 1 week after the race. The SAB thickness was measured in the longitudinal plane of supraspinatus, with other abnormailities also recorded. The swimmers completed questionnaires detailing presence and severity of shoulder pain, volume of swimming completed that week and their breathing pattern. SAB thickness increased with season progression: mean of 1.55 (± 0.68) 4 months prior to the race, 1.63 (± 0.68) 2 weeks prior to the race and 1.86 (± 0.69) 1 week after the race. SAB thickness is significantly (p=0.05) correlated (β=0.11) with kilometres swum in the pool in the preceding week. SAB thickness was not significantly correlated with pain when measured prior to the race. However, at 1 week post race, SAB thickness of shoulders with pain were significantly greater than those without pain, p-value=0.032. SAB thickness increases with increasing swimming training. Commonly, this increase is not correlated to pain, suggestive of a painless adaptive process. The significant correlation between pain and SAB thickness soon after an exacerbating event suggests that painful acute SAB thickening is a different entity to chronic, painless adaptive SAB thickening. These two entities can only be differentiated by clinical history and examination. Copyright © 2014 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  6. Physical tests for shoulder impingements and local lesions of bursa, tendon or labrum that may accompany impingement.

    Science.gov (United States)

    Hanchard, Nigel C A; Lenza, Mário; Handoll, Helen H G; Takwoingi, Yemisi

    2013-04-30

    Impingement is a common cause of shoulder pain. Impingement mechanisms may occur subacromially (under the coraco-acromial arch) or internally (within the shoulder joint), and a number of secondary pathologies may be associated. These include subacromial-subdeltoid bursitis (inflammation of the subacromial portion of the bursa, the subdeltoid portion, or both), tendinopathy or tears affecting the rotator cuff or the long head of biceps tendon, and glenoid labral damage. Accurate diagnosis based on physical tests would facilitate early optimisation of the clinical management approach. Most people with shoulder pain are diagnosed and managed in the primary care setting. To evaluate the diagnostic accuracy of physical tests for shoulder impingements (subacromial or internal) or local lesions of bursa, rotator cuff or labrum that may accompany impingement, in people whose symptoms and/or history suggest any of these disorders. We searched electronic databases for primary studies in two stages. In the first stage, we searched MEDLINE, EMBASE, CINAHL, AMED and DARE (all from inception to November 2005). In the second stage, we searched MEDLINE, EMBASE and AMED (2005 to 15 February 2010). Searches were delimited to articles written in English. We considered for inclusion diagnostic test accuracy studies that directly compared the accuracy of one or more physical index tests for shoulder impingement against a reference test in any clinical setting. We considered diagnostic test accuracy studies with cross-sectional or cohort designs (retrospective or prospective), case-control studies and randomised controlled trials. Two pairs of review authors independently performed study selection, assessed the study quality using QUADAS, and extracted data onto a purpose-designed form, noting patient characteristics (including care setting), study design, index tests and reference standard, and the diagnostic 2 x 2 table. We presented information on sensitivities and specificities with

  7. Tenoscopy of the navicular bursa: a new therapeutic approach for horses affected by "palmar pain syndrome." Endoscopic technique review and personal experiences.

    Science.gov (United States)

    Scandella, M; Lazzaretti, S S; De Zani, D; Cassano, M; Zani, D D; Ravasio, G; Gualtieri, M

    2010-06-01

    Tenoscopy of the navicular bursa has been recently introduced as a diagnostic and therapeutic treatment in cases of palmar foot pain syndrome. A deep digital flexor tendon transthecal approach was suggested in 1999, and the endoscopic technique has been reviewed. Smith and coworkers have recently reported good and promising results. An anatomic cadaver limb study was performed, and the endoscopic technique was evaluated. Subsequently, a 14-year-old Argentine mare, affected by palmar foot pain syndrome, was treated. Clinical data, MRI and endoscopic findings, and a 6-month follow-up evaluation are reported.

  8. PENGARUH ROTASI AUDIT, WORKLOAD, DAN SPESIALISASI TERHADAP KUALITAS AUDIT PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA PADA TAHUN 2009-2013

    Directory of Open Access Journals (Sweden)

    Febrian Adhi Pratama Ishak

    2016-01-01

    Full Text Available This purpose research is for to understand the effect of structure corporate governance to performance companies listing on the Indonesia Stock Exchange in 2012-2014. The sample used in this study were manufacturing  sector companies for the year 2012-2014. The method used in data collection is the secondary method of data collection, financial report its being obtained from website IDX. The method of analysis of this study used multiple regression .The result from research is indicate that structure corporate governance is significant effect on performance of manufacturing companies. Tujuan penelitian ini adalah untuk memahami efek dari struktur tata kelola perusahaan pada perusahaan yang listing di Bursa Efek Indonesia pada 2012-2014. Sampel yang digunakan dalam penelitian ini adalah perusahaan manufaktur sektor untuk tahun 2012-2014. Metode yang digunakan dalam pengumpulan data adalah metode pengumpulan data sekunder berupa laporan keuangan yang diperoleh dari website Bursa Efek Indonesia. Metode analisis penelitian ini menggunakan regresi berganda. Hasil dari penelitian adalah menunjukkan struktur yang tata kelola perusahaan yang berpengaruh signifikan terhadap kinerja perusahaan manufaktur.

  9. PENGARUH PROFITABILITY DAN INVESTMENT OPPORTUNITY SET TERHADAP KEBIJAKAN DIVIDEN TUNAI DENGAN LIKUIDITAS SEBAGAI VARIABEL PENGUAT (Studi pada Perusahaan yang Terdaftar di Bursa Efek Jakarta

    Directory of Open Access Journals (Sweden)

    Michell Suharli

    2007-01-01

    Full Text Available The objective of this research is to study influence of profitability and investment opportunity as independent variable, and liquidity as moderating variable toward cash dividend. It is interesting to analyze factors that influence dividend policy because to many considerations. Sometimes those considerations cause conflict between many parties. Research object is companies that delisting in Bursa Efek Jakarta that paid dividend. Research sample using purposive sampling of companies for period ended 2002 and 2003. This research concludes that both of two independent variables have significant influence toward dividend amount policy, and liquidity moderate the influence. Abstract in Bahasa Indonesia : Penelitian ini bermaksud menguji pengaruh profitabilitas dan kesempatan investasi terhadap kebijakan jumlah dividen kas perusahaan publik di Jakarta dengan menggunakan likuiditas sebagai variabel penguat (variabel moderator. Profitabilitas diukur dengan return on investment (ROI, kesempatan investasi diproksikan oleh fixed assets, dan liquiditas sebagai variabel moderat diproksikan oleh current ratio di Bursa Efek Jakarta.. Populasi penelitian ini adalah seluruh perusahaan di Indonesia yang listing di BEJ dan membagikan dividen pada tahun 2002-2003. Hasil penelitian ini adalah kebijakan jumlah pembagian dividen perusahaan dipengaruhi oleh profitabilitas dan diperkuat oleh likuiditas perusahaan. Kata kunci: dividen, profitabilitas, return on investment

  10. ANALISIS VARIABEL YANG MEMPENGARUHI PRICE EARNING RATIO DALAM PENILAIAN HARGA SAHAM DI BURSA EFEK JAKARTA (TAHUN 1998 – 2001

    Directory of Open Access Journals (Sweden)

    Marli - -

    2012-05-01

    Full Text Available ABSTRAK Penilaian harga saham berdasarkan analisa fundamental diklasifikasikan pada pendekatan dividend discount model dan P/E ratio. Permasalahan yang penting dalam penelitian ini menyangkut tentang aplikasi penilaian harga saham berdasarkan pendekatan PER dengan menggunakan variabel bebas yang dianggap relevan mempengaruhi harga saham. Selain itu, juga dapat digunakan untuk menjelaskan kondisi harga saham, variabel mana yang dominan dan bagaimana perubahan harga sahamnya dengan acuan pada pendekatan P/E ratio. Variabel yang dipertimbangkan oleh investor dalam melakukan investasi di pasar modal diantaranya dividend payout ratio, standard deviation of EPS, return on equity dan debt to equity ratio sedangkan earning growth tetap dipertimbangkan tetapi dengan tingkat signifikansi yang lebih rendah. Return on equity merupakan variabel penelitian yang paling dominan mempengaruhi harga saham. Harga saham di Bursa efek Jakarta belum menunjukkan harga yang wajar dan berdasarkan analisa teknikal dengan menggunakan indikator moving average dan trend, kecenderungan perubahan harga sahamnya tidak selalu menuju nilai intrinsiknya. Kata kunci: P/E ratio, return on equity, debt to equity ratio ABSTRACT The assessment of stock price based on fundamental analyse is grouped on model discount dividend approach and P/E ratio. The important problems in this research include assessment stock price application based on PER approach using independent variable which have relevant influence at stock price. It also used to explain stock price condition, dominant variable, and how is the changing of stock price with based on P/E ratio approach. Variable considered by investor on conducting investment in stock exchange market are: dividend payout ratio, standard deviation of EPS, return on equity, and debt to equity ratio while earning growth also considered but at lower significance level. Return on equity is dominant influence research variable on stock price. Stock

  11. PENGARUH RISIKO KREDIT DAN EFISIENSI OPERASIONAL TERHADAP KINERJA BANK (Studi Empirik pada Bank yang Terdaftar di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Bambang Sudiyatno

    2015-04-01

    Full Text Available Penelitian ini menguji pengaruh risiko kredit dan efisiensi operasional, terhadap kinerja bank yang terdaftar di Bursa Efek Indonesia periode 2007-2010. Risiko kredit diproksi dengan Loan to Deposit Ratio (LDR, dan efisiensi operasional diproksi dengan Capital Adecuacy Ratio (CAR dan Biaya Operasi (BOPO, sedangkan kinerja bank diproksi dengan Return on Asset (ROA. Tujuan penelitian ini adalah untuk mengidentifikasi faktor mana, dari risiko kredit dan efisiensi operasi yang pengaruhnya lebih besar terhadap kinerja bank. Sampel yang diambil dalam penelitian ini sebanyak 96 perusahaan perbankan selama tahun 20072010, yang dipilih dengan metode purposive sampling. Untuk mendapatkan informasi yang dibutuhkan dilakukan proses pengumpulan data melalui dokumentasi. Tehnik analisis data dilakukan dengan analisis regresi linier berganda, untuk mengetahui adanya pengaruh CAR, BOPO, dan LDR terhadap ROA. Hasil analisis menunjukan bahwa rasio keuangan, yang terdiri dari rasio CAR dan LDR berpengaruh positif tetapi tidak signifikan terhadap ROA. Sedangkan BOPO berpengaruh negative dan signifikan terhadap ROA. Kemampuan prediksi dari tiga variabel tersebut terhadap ROA sebesar 18,8% sebagaimana yang telah ditunjukan oleh adjusted R square sebesar 0,188. This study examined the effect of credit risk and operational efficiency on the performance of banks listed on the Indonesia Stock Exchange between 2007-2010. Credit risk proxied by Loan to Deposit Ratio (LDR, and operational efficiency proxied by Capital Adecuacy Ratio (CAR and Operating Costs (BOPO, while the bank's performance proxied by Return on Assets (ROA. The purpose of this study was to identify which factors, from credit risk and operating efficiencies greatest influence on the performance of banks. Samples taken in this study were 96 banking companies during the years 2007 to 2010, were selected by purposive sampling method. To get the required information, performed the data collection process

  12. Popüler Roman ve Gençler Üzerindeki Etkileri- Bursa Örneği- Popular Novel and Its Effects on the Young-Bursa Example-

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    Fatih ACER

    2013-07-01

    study many topics such as why popular novel has such popularity among the young, what it adds to the young's lives, the family and the environment factors in the preference of this novel, whether it will become a transition step to the aesthetic novel, the meaning of popular novel in the eye of the young, the influence of the school types on the novels selected, have been presented through the questionnaires and conclusions from their results. The research area was restricted to Bursa province. The questionnaires were conducted in 2011-2012 Education Year in a sample school from each type of the secondary education institutions in Bursa. In these schools, the questionnaires were applied to 421 students who were reading popular novel and chosen by literature teachers. In this study cross-graphics were obtained by using SPSS programme 15. In conclusion and suggestions part of this study, the results were presented as conclusions deduced from the comparisons made in the tables. Bu makalenin amacı öncelikle gençlerin popüler romanları tercih sebeplerini tespit etmektir. Tercih edilen popüler romanların gençlerin hayatına nasıl bir anlam kattığı ve bu türün estetik romanlara oranla çok okunmasının altında yatan sebepler ortaya konmuştur. Giriş bölümünde popüler romanın genel özellikleri verilmiştir. Bu bölümde popüler romanın çok da kayda değer bir tür olmadığı algısının yaygın olduğu belirtilmiştir. Yazarı açısından estetik gaye güdülmeksizin kaleme alınan; yayılıp yazılmasında başta ticari kaygı olmak üzere, sanat dışı sebepler bulunan; okurun fikrinden çok duygu ve heyecanlarını harekete geçirmeyi hedefleyen; çok sayıda okura ulaşan; kolay anlaşılıp rahat çözümlenen; okurda belli bir seviye aramayan basma kalıp bir yapı arz eden; bir çoğu filme alınarak okur dışında sinema ve televizyonda da çok sayıda izleyiciye ulaşmış nitelikteki romanlardır. Bunun yanında yazarı taraf

  13. ANALISIS VARIABEL YANG MEMPENGARUHI EARNINGS PER SHARE PADA INDUSTRI FOOD AND BAVERAGES YANG GO PUBLIC DI BURSA EFEK JAKARTA

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    SUTEJO - -

    2012-05-01

    Full Text Available ABSTRAK Ide penelitian ini didasarkan pada kenyataan bahwa para investor bersedia melakukan investasi, kalau obyek investasi tersebut mampu menghasilkan keuntungan yang lebih tinggi dari obyek investasi lainya, sehingga perusahaan yang go public harus menarik bagi calon investor. Earnings per share merupakan salah satu indikator utama yang digunakan investor dalam melihat daya tarik suatu saham. Informasi ini akan bermanfaat bagi pengambilan keputusan di bidang keuangan pada industri food and baverages yang menjual sahamnya di Bursa Efek Jakarta. Tujuan penelitian ini adalah untuk mengidentifikasi pengaruh variabel-variabel return on equity (X1, net sales (X2, current ratio (X3, debt to equity (X4, inventory turnover (X5, total assets turnover (X6, dan net profit margin (X7 terhadap earnings per share, baik secara simultan maupun secara partial. Penelitian ini dilakukan dengan mengambil keseluruhan elemen populasi industri food and baverages yang go public di Bursa Efek Jakarta, mulai tahun 1992 sampai dengan tahun 1996 dengan rincian sebagai berikut: tahun 1992 berjumlah 9 perusahaan, tahun 1993 berjumlah 15 perusahaan, tahun 1994 berjumlah 19 perusahaan, tahun 1995 berjumlah 20 perusahaan dan tahun 1996 berjumlah 20 perusahaan. Analisis yang digunakan dalam penelitian ini adalah analisis regresi berganda, dengan hasil sebagai berikut : Pertama, return on equity (X1, net sales (X2, current ratio (X3, debt to equity (X4, inventory turnover (X5, total assets turnover (X6, dan net profit margin (X7 secara simultan berpengaruh dalam menentukan variabilitas earnings per share. Kedua, diantara berbagai variabel bebas tersebut hanya inventory turnover (X5 yang tidak berpengaruh secara signifikan dalam menentukan variabilitas earnings per share, hal ini tentunya tidak terlepas dari kenyataan pada industri food and baverages di Indonesia, dimana untuk menjamin kelancaran dan kualitas bahan baku yang dibeli, perusahaan harus memberikan bantuan teknis

  14. Migration of calcium deposits into subacromial-subdeltoid bursa and into humeral head as a rare complication of calcifying tendinitis: sonography and imaging.

    Science.gov (United States)

    Della Valle, Valeria; Bassi, Emilio Maria; Calliada, Fabrizio

    2015-09-01

    Calcifying tendinitis of the shoulder is a common condition characterized by the deposition of calcium, predominantly hydroxyapatite crystals, in the rotator cuff. A rare complication of this condition is the migration of calcium deposits from tendons, usually the supraspinatus, into the subacromial-subdeltoid bursa or into the humeral greater tuberosity. These complications are responsible for intense acute shoulder pain and functional disability. Patient anamnesis and clinical symptoms must be considered to make the diagnosis, but imaging, particularly sonography, is often necessary, showing a typical presentation related to the locations of calcium deposits. We present sonographic and other imaging features of subacromial-subdeltoid bursitis and humeral osteitis related to the migration of calcium.

  15. LIPOMA ARBORESCENS: RARE CASE OF ROTATOR CUFF TEAR ASSOCIATED WITH THE PRESENCE OF LIPOMA ARBORESCENS IN THE SUBACROMIAL-SUBDELTOID AND GLENOHUMERAL BURSA.

    Science.gov (United States)

    Benegas, Eduardo; Neto, Arnaldo Amado Ferreiro; Teodoro, Daniel Sabatini; da Silva, Marcos Vinícius Muriano; de Oliveira, Augusto Medaglia; Filippi, Renée Zon; de Santis Prada, Flávia

    2012-01-01

    Lipoma arborescens is a rare intra-articular disease that is usually monoarticular and is characterized by extensive proliferation of the synovial villi and hyperplasia of the subsynovial fat. The synovial tissue is progressively replaced by mature fat cells in the synovial membrane. The present study reports a case of a rare condition of lipoma arborescens that was simultaneously intra-articular (glenohumeral joint) and in the subacromial-subdeltoid bursa, in association with a torn supraspinatus tendon. The clinical, histological and radiographic presentations and treatment are discussed here. The description of this case includes radiographic and magnetic resonance evaluations and pathological examination. Although lipoma arborescens is a rare condition, it should be taken into consideration in cases presenting synovial hyperproliferation and synovial fat replacement.

  16. ANALISIS PERBANDINGAN KEMAMPUAN PREDIKSI KEBANGKRUTAN ANTARA ANALISIS ALTMAN, ANALISIS OHLSON DAN ANALISIS ZMIJEWSKI PADA SEKTOR INDUSTRI TEKSTIL YANG GO PUBLIC DI BURSA EFEK INDONESIA PERIODE 2008-2012

    Directory of Open Access Journals (Sweden)

    Bethani Suryawardani

    2016-03-01

      Abstrak - Penelitian ini bertujuan untuk mengetahui perbedaan antara Altman Modifikasi Model, Model Zmijewski dan Model Ohlson dalam memprediksi kebangkrutan pada perusahaan Tekstil dan Garment yang terdaftar di Bursa Efek Indonesia dari tahun 2008 sampai 2012. Metode penelitian yang digunakan dalam penelitian ini adalah deskriptif komparatif untuk menjelaskan dan membandingkan tiga metode untuk prediksi kebangkrutan. Hasil penelitian ini menunjukkan bahwa Metode Ohlson (O-Score terbukti lebih akurat dalam memprediksi kebangkrutan (kesulitan keuangan, terutama untuk Industri Tekstil dan Garmen karena memiliki akurasi yang lebih tinggi yaitu dengan tingkat probabilitas akurasi 97,8%, itu dibuktikan dengan hasil perhitungan, dimana hanya perusahaan HDTX pada tahun 2011 yang tidak diprediksi bangkrut di masa depan. Sedangkan metode Altman Modifikasi (Z" Score hanya dapat memprediksi kondisi kesulitan keuangan (financial distress untuk perusahaan dengan akurasi 73,3%. Model Zmijewski (X-Score dapat memprediksi kebangkrutan bagi perusahaan sebesar 60% selama periode penelitian.   Kata Kunci: Kebangkrutan, Altman Modifikasi, Ohlson, Zmijewski, Kesulitan Keuangan

  17. PENGARUH KEPUTUSAN INVESTASI, PENDANAAN, KEBIJAKAN DEVIDEN TERHADAP NILAI PERUSAHAAN (Studi Pada Perusahaan Sektor Property dan Real Estate Di Bursa Efek Indonesia Periode 2011 s.d 2014

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    muharti muharti

    2017-09-01

    Full Text Available Abstrak: Penelitian ini bertujuan untuk menguji pengaruh keputusan investasi, pendanaan dan kebijakan deviden terhadap nilai perusahaan. Sampel dalam penelitian ini adalah perusahaan properti dan real estate yang terdaftar di Bursa Efek Indonesia periode 2011 – 2014 sebanyak 17 perusahaan. Untuk menguji hipotesis penelitian ini, alat analisa data yang digunakan adalah SEM-PLS dengan menggunakan software WarpPLS 6.0. Hasil penelitian ini menunjukkan keputusan investasi berepngaruh positif terhadap nilai perusahaan. Begitu juga dengan keputusan pendanaan yang berpengaruh positif terhadap nilai perusahaan. Dan terakhir kebijakan deviden berpengaruh positif terhadap nilai perusahaan. Dari ketiga variable tersebut, keputusan pendanaan merupakan variabel penting dalam mempengaruhi nilai perusahaan Karena memiliki effect size (nilai praktis yang kuat.Kata kunci :     Keputusan investasi, keputusan pendanaan, kebijakan deviden, nilai perusahaan.

  18. PENGARUH CORPORATE SOCIAL RESPONSIBILITY INDEKS TERHADAP KINERJA PERUSAHAAN (STUDY PADA PERUSAHAAN INFRASTRUKTUR, UTILITAS, DAN TRANSPORTASI YANG LISTING DI BURSA EFEK INDONESIA

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    Ika Mar’atus Sholihah

    2013-10-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui pengaruh corporate social responsibility indeks terhadap kinerja perusahaan. Dalam penelitian ini, kinerja keuangan perusahaan diukur dengan menggunakan ROA (Return On Asset. Sampel yang digunakan dalam penelitian ini adalah semua perusahaan infrastruktur, utilitas, dan transportasi yang listing di Bursa Efek Indonesia dan menerbitkan annual report pada tahun 2010-2012 di website www.idx.co.id dengan menggunakan metode purposive judgemen. Metode analisis yang digunakan pada penelitian regresi berganda. Berdasarkan hasil pengujian, ditemukan bahwa variabel corporate social responsibility (CSR berpengaruh positif terhadap kinerja perusahaan. Sementara hasil uji signifikasi diketahui corporate social responsibility indeks secara parsial tidak berpengaruh terhadap kinerja perusahaan, hanya variabel kontrol leverage saja yang berpengaruh secara signifikan terhadap kinerja perusahaan

  19. ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI MINAT PEMANFAATAN SISTEM INFORMASI DAN PENGGUNAAN SISTEM INFORMASI (Studi Empiris Pada Perusahaan Manufaktur di Bursa Efek Jakarta

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    Rini Handayani

    2007-01-01

    Full Text Available The objectives of the research are to examine some factors that influence intention of utilization of information system and information system usage. The study is based on the model proposed by Venkatesh et al.,(2003. This study used data that obtained from individual perception of information sistem user in manufacture company that have losted at Bursa Efek Jakarta. Three hundred questionnaires have sent to companies, 83 questionnaires were returned, and only 60 questionnaires can be used. The data were analyzed by using multiple regression by SPSS 11.5 software. Study results show that performance expectancy, effort expectancy and social factor are significant positive influence to intention of information system. Facilitating conditions give significant positive influence to information system usage and intention of information system is insignificant positive influence to information system usage. Abstract in Bahasa Indonesia : Tujuan penelitian ini adalah untuk menguji faktor-faktor yang mempengaruhi minat pemanfaatan sistem informasi dan pengaruhnya terhadap penggunaan sistem informasi dengan menguji model yang diajukan oleh Venkatesh et al. (2003. Data diperoleh dari persepsi individu pemakai sistem informasi pada perusahaan manufaktur yang terdaftar di Bursa Efek Jakarta. Sebanyak 83 kuesioner kembali dari 300 yang dikirim dan 60 kuesioner yang dapat diolah. Dengan menggunakan teknik regresi berganda, hasil penelitian menunjukkan bahwa ekspektasi kinerja dan ekspektasi usaha dan faktor sosial berpengaruh positif signifikan terhadap minat pemanfaatan sistem informasi. Kondisi-kondisi yang memfasilitas pemakai berpengaruh positif signifikan terhadap penggunaan sistem informasi dan minat pemanfaatan sistem informasi tidak berpengaruh terhadap penggunaan sistem informasi. Kata kunci: ekspektasi kinerja, ekspektasi usaha dan faktor sosial.

  20. MRI of adhesive capsulitis of the shoulder: Distension of the bursa in the superior subscapularis recess is a suggestive sign of the pathology

    Energy Technology Data Exchange (ETDEWEB)

    Carbone, Stefano, E-mail: stefcarbone@yahoo.it [Department of Orthopaedic and Traumatology, University of Rome Sapienza (Italy); Napoli, Alessandro [Department of Radiologic Sciences, University of Rome Sapienza (Italy); Gumina, Stefano [Department of Orthopaedic and Traumatology, University of Rome Sapienza (Italy)

    2014-02-15

    Objective: To evaluate the diagnostic values of the superior subscapularis recess sign in patients with shoulder adhesive capsulitis. The sign consists in evaluating in MRI of the shoulder the presence of fluid distension of the bursa in the superior subscapularis recess. Materials and methods: We evaluated MRI of 165 shoulders in 48 consecutive patients with a diagnosis of shoulder adhesive capsulitis in the freezing phase (group I), in 49 short-wide superior cuff tear (group II) and in 65 controls (group III) between 2010 and 2013. On the T2 weighted images, we evaluated the presence of an high intensity signal within the superior subscapularis recess, consistent with fluid distension of the bursa. Results: The sign was found in 43/48 patients (89.58%) with shoulder adhesive capsulitis in 3/49 (6.12%) patients with superior cuff tear and in 1/65 controls (1.53%) (p < 0.001). The mean diagnostic values were: sensibility 0.91; specificity 0.96–0.98; positive predictive value 0.93–0.97; negative predictive value 0.92–0.94; likelihood ratios for an abnormal test result 15.16–60.6; likelihood ratios for a normal test result 0.086–0.095. Conclusion: For the orthopedic surgeon or the clinician, the sign is useful to confirm in MRI the clinical diagnosis of shoulder adhesive capsulitis; accordingly, the radiologist should describe and relate this sign to the pathology in the report, looking eventually for further typical sign of shoulder adhesive capsulitis.

  1. MRI of adhesive capsulitis of the shoulder: distension of the bursa in the superior subscapularis recess is a suggestive sign of the pathology.

    Science.gov (United States)

    Carbone, Stefano; Napoli, Alessandro; Gumina, Stefano

    2014-02-01

    To evaluate the diagnostic values of the superior subscapularis recess sign in patients with shoulder adhesive capsulitis. The sign consists in evaluating in MRI of the shoulder the presence of fluid distension of the bursa in the superior subscapularis recess. We evaluated MRI of 165 shoulders in 48 consecutive patients with a diagnosis of shoulder adhesive capsulitis in the freezing phase (group I), in 49 short-wide superior cuff tear (group II) and in 65 controls (group III) between 2010 and 2013. On the T2 weighted images, we evaluated the presence of an high intensity signal within the superior subscapularis recess, consistent with fluid distension of the bursa. The sign was found in 43/48 patients (89.58%) with shoulder adhesive capsulitis in 3/49 (6.12%) patients with superior cuff tear and in 1/65 controls (1.53%) (p<0.001). The mean diagnostic values were: sensibility 0.91; specificity 0.96-0.98; positive predictive value 0.93-0.97; negative predictive value 0.92-0.94; likelihood ratios for an abnormal test result 15.16-60.6; likelihood ratios for a normal test result 0.086-0.095. For the orthopedic surgeon or the clinician, the sign is useful to confirm in MRI the clinical diagnosis of shoulder adhesive capsulitis; accordingly, the radiologist should describe and relate this sign to the pathology in the report, looking eventually for further typical sign of shoulder adhesive capsulitis. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  2. Testing some of Benjamin Graham’s Stock Selection Criteria: A Case of the FTSE Bursa Malaysia EMAS Index from Year 2000 to 2009

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    Desmond Chang

    2011-01-01

    Full Text Available Benjamin Graham, also known as the “father of value investing” proposed that investment in the stock exchange can be a safe endeavor while receiving gains that outperform the market if the investor makes carefully thought out purchases. This study aims to determine if the use of some of Benjamin Graham’s stock selection criteria is able to generate returns that are significantly greater than the returns in the stock exchange of Malaysia, particularly, the comprehensive FTSE Bursa Malaysia EMAS Index. This study collected secondary data regarding fundamentals of companies listed in the FTSE Bursa Malaysia EMAS Index from the year 2000 to 2009. Five criteria were set up in this research based on one or a combination of price-to-earnings ratio, price-to-book value, current ratio and dividend yield. The listed companies were screened using those criteria. An equally weighted portfolio was created using the screened companies and their one-year and two-year returns calculated. The returns were compared to the market return. Hypotheses of this research were tested using t-test statistic to determine the significance of the data. This research found that most of the screening criteria used generated returns that were higher than the market return in almost every year they were tested in. Benjamin Graham’s stock selection criteria although have been conceived over 80 years ago is still applicable today in the Malaysian market. Further research can be conducted with different criteria with varying holding periods and in different markets.

  3. Transgenic tobacco plants over expressing cold regulated protein CbCOR15b from Capsella bursa-pastoris exhibit enhanced cold tolerance.

    Science.gov (United States)

    Wu, Lihua; Zhou, Mingqi; Shen, Chen; Liang, Jing; Lin, Juan

    2012-09-15

    Low temperature is among the most significant abiotic stresses, restricting the habitats of sessile plants and reducing crop productivity. Cold regulated (COR) genes are low temperature-responsive genes expressing under regulation of a specific signal transduction pathway, which is designated C-repeat-binding-factor (CBF) signaling pathway. In the present article, cold bioassay showed that the transcript level of cold regulated gene CbCOR15b from shepherd's purse (Capsella bursa-pastoris) was obviously elevated under cold treatments. Reverse transcription-PCR (RT-PCR) and GUS report system revealed that unlike AtCOR15b, CbCOR15b expressed not only in leaves but also in stems and maturation zone of roots. When transgenic tobacco plants ectopically expressing CbCOR15b were exposed to chilling and freezing temperatures, they displayed more cold tolerance compared to control plants. According to the electrolyte leakage, the relative water content, the glucose content and the phenotype observation, CbCOR15b transformants suffered less damage under cold stress. Further investigation of the subcellular localization of CbCOR15b by transient expression of fusion protein CbCOR15b-GFP revealed that it was localized exclusively in the chloroplasts of tobacco mesophyll cells and in the cytoplasm of onion epidermal cells. It can be concluded that CbCOR15b which located in the chloroplasts and in the cytoplasm of cells without chloroplasts was involved in cold response of C. bursa-pastoris and conferred enhanced cold tolerance in transgenic tobacco plants. Copyright © 2012 Elsevier GmbH. All rights reserved.

  4. Antibacterial activity of Tribulus terrestris and its synergistic effect with Capsella bursa-pastoris and Glycyrrhiza glabra against oral pathogens: an in-vitro study

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    Saman Soleimanpour

    2015-04-01

    Full Text Available Objective: In this study, antimicrobial activities of an ethanol extract of Tribulus terrestris aloneand in combination with Capsella bursa-pastoris and Glycyrrhiza glabra were examined in vitro against six pathogens namely Streptococcus mutans, Streptococcus sanguis, Actinomyces viscosus, Enterococcus faecalis Staphylococcus aureus, and Escherichia coli. Materials and methods: Antibacterial activities of the extracts were examined using disc and well diffusion methods and the minimum inhibitory concentration (MIC and minimum bactericidal concentration (MBC of ethanol extracts were determined against these microorganisms using agar and broth dilution methods. Chlorhexidine was used as positive control. Results: Tribulus terrestris extract exhibited good antibacterial activity against all bacteria. Antibacterial activity of mixed extract was evaluated and exhibited that mixed extract was more effective against all bacteria than any of the cases alone which indicates the synergistic effect between these three extracts (p˂0.05. No strain showed resistance against these extracts. In agar dilution, Tribulus terrestris exhibited MIC values ranging from 35.0 to 20.0 mg/ml and mixed extract showed MIC values ranging from 12.5 to 5.0 mg/ml. The results of broth dilution method were consistent with the findings of the agar dilution method. Conclusion: This in-vitro study was a preliminary evaluation of antibacterial activity of the plants. It provided scientific evidence to support uses of T. terrestris and its mixture with C. bursa-pastoris and G. glabra for the treatment of oral infections. In-vivo studies are also required to better evaluate the effect of these extracts.

  5. 30 Years Retrospective Review of Tuberculosis Cases in a Tuberculosis Dispensary in Bursa/Nilufer, Turkey (1985-2014): Changes of Epidemics().

    Science.gov (United States)

    Pala, Kayıhan; Gerçek, Harika; Taş, Tuncay Aydin; Çakir, Rukiye; Özgüç, Sedef; Yildiz, Timur

    2016-01-01

    The aim of this study is to describe the epidemiological and clinical aspects of patients who applied to the Bursa Nilufer Tuberculosis Dispensary by investigating the trends in epidemics over three decades. In this retrospective observational study, the records of all tuberculosis cases (1630 patients) treated in the last 30 years (1985-2014) at the Bursa Nilufer Tuberculosis Dispensary were examined and statistically analyzed. Males comprised 65.2% of the patients. The ages of the patients ranged from 1 to 87 years, and the mean age was 37.4 (95% CI: 36.6-38.2). Among the cases, 86.7% were new infections and 74.1% were pulmonary tuberculosis. In the last decade, the education level, the percentage of patients who had received a BCG vaccination, the proportion of women and active employees among them increased (p<0.05), while it decreased among men (p<0.05). Clinical symptoms accompanying TB such as weakness, anorexia, weight loss, and cough, decreased to a statistically significant degree (p<0.05). In the last decade, the mortality rate was 3.6% and increased compared with previous decades (p<0.05). Mortality was higher among patients who were elderly, male, did not have a BCG scar or had a chronic disease (p<0.05). This study adds information about the change of TB epidemics in Turkey in the last 30 years. Further studies are needed to determine the risk factors associated with tuberculosis mortality and to evaluate the effectiveness control programs of this disease.

  6. 30 Years Retrospective Review of Tuberculosis Cases in a Tuberculosis Dispensary in Bursa/Nilufer, Turkey (1985–2014): Changes of Epidemics*

    Science.gov (United States)

    Pala, Kayıhan; Gerçek, Harika; Taş, Tuncay Aydin; Çakir, Rukiye; Özgüç, Sedef; Yildiz, Timur

    2016-01-01

    Objective The aim of this study is to describe the epidemiological and clinical aspects of patients who applied to the Bursa Nilufer Tuberculosis Dispensary by investigating the trends in epidemics over three decades. Method In this retrospective observational study, the records of all tuberculosis cases (1630 patients) treated in the last 30 years (1985–2014) at the Bursa Nilufer Tuberculosis Dispensary were examined and statistically analyzed. Results Males comprised 65.2% of the patients. The ages of the patients ranged from 1 to 87 years, and the mean age was 37.4 (95% CI: 36.6–38.2). Among the cases, 86.7% were new infections and 74.1% were pulmonary tuberculosis. In the last decade, the education level, the percentage of patients who had received a BCG vaccination, the proportion of women and active employees among them increased (p<0.05), while it decreased among men (p<0.05). Clinical symptoms accompanying TB such as weakness, anorexia, weight loss, and cough, decreased to a statistically significant degree (p<0.05). In the last decade, the mortality rate was 3.6% and increased compared with previous decades (p<0.05). Mortality was higher among patients who were elderly, male, did not have a BCG scar or had a chronic disease (p<0.05). Conclusion This study adds information about the change of TB epidemics in Turkey in the last 30 years. Further studies are needed to determine the risk factors associated with tuberculosis mortality and to evaluate the effectiveness control programs of this disease. PMID:27872739

  7. ANALISIS VARIABEL YANG MEMPENGARUHI EARNINGS PER SHARE PADA INDUSTRI FOOD AND BAVERAGES YANG GO PUBLIC DI BURSA EFEK JAKARTA

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    Sutejo - -

    2012-05-01

    Full Text Available ABSTRAK Tujuan penelitian ini adalah untuk mengidentifikasi pengaruh variabel-variabel return on equity (X1, net sales (X2, current ratio (X3, debt to equity (X4, inventory turnover (X5, total assets turnover (X6, dan net profit margin (X7 terhadap earnings per share, baik secara simultan maupun secara partial. Penelitian ini dilakukan dengan mengambil keseluruhan elemen populasi industri food and baverages yang go public di Bursa Efek Jakarta, mulai tahun 1992 sampai dengan tahun 1996 dengan rincian sebagai berikut: tahun 1992 berjumlah 9 perusahaan, tahun 1993 berjumlah 15 perusahaan, tahun 1994 berjumlah 19 perusahaan, tahun 1995 berjumlah 20 perusahaan dan tahun 1996 berjumlah 20 perusahaan. Hasil penelitian menunjukkan bahwa return on equity (X1, net sales (X2, current ratio (X3, debt to equity (X4, inventory turnover (X5, total assets turnover (X6, dan net profit margin (X7 secara simultan berpengaruh dalam menentukan variabilitas earnings per share. Variabel inventory turnover (X5 tidak mempengaruhi variabilitas earnings per share, hal ini tentunya tidak terlepas dari kenyataan pada industri food and baverages di Indonesia, dimana untuk menjamin kelancaran dan kualitas bahan baku yang dibeli, perusahaan harus memberikan bantuan teknis maupun modal kerja kepada para supplier lokal, sehingga perusahaan harus menyediakan modal atau kredit lunak dalam rangka kerja sama yang saling menguntungkan. Di sisi lain bahan baku industri food and baverages dalam prakteknya dipengaruhi oleh keberhasilan dan kegagalan panen para supplier, sehingga dari berbagai kendala yang dihadapi industri food and baverages tersebut sebagai akibatnya kadang-kadang bahan baku melimpah dan tidak jarang mengalami kekurangan atau menghadapi kelangkaan. Oleh karena itu tingginya tingkat perputaran persediaan tidak dapat menunjukan efisiensi perusahaan. Diantara variabel bebas yang berpengaruh signifikan tersebut net sales (X2, dan current ratio (X3 mempunyai pengaruh

  8. Bursa'da Tüketime Sunulan Bazı Gıdalarda Yersinia enterocolitica 'nın Varlığının Araştırılması

    OpenAIRE

    EVRENSEL, Süreyya SALTAN; YÜKSEK, Nur; Temelli, Seran

    2006-01-01

    A toal of 100 samples composed of various cheese types (white pickled cheese, kashar, tulum, mihalic, processed and curd cheese) and meat products (ground beef, meat balls, fermented-pasteurized sausage and sausage) purchased from supermarkets in Bursa, were examined for the presence of Yersinia enterocolitica (Y. enterocolitica). Six out of 100 of these samples were found to be Y. enterocolitica positive. Y. enterocolitica was identified in 2 of the white pickled cheese, 2 of the ground beef...

  9. Pengaruh Struktur Kepemilikan Saham Leverage Faktor Intern Dan Faktor Ekstern Terhadap Nilai Perusahaan (Studi empirik pada perusahaan manufaktur dan non manufaktur di Bursa Efek Jakarta

    Directory of Open Access Journals (Sweden)

    Sujoko

    2007-01-01

    Full Text Available The main objective of the study is to examine the impact of ownership structure%2C leverage%2C external factor%2C internal factor on the value of the firms in Jakarta Stock Exchange. It is argued that unlike the agency problem advanced stock market%2C the agency problem in the Jakarta Stock Exchange is the divergence of interest between the minority holders and majority holders. This is because the Jakarta Stock Exchange is characterized%2C among other things%2C by the domination of large shareholders. It is hypotheses that :(1 there are the impact ownership structure %2C external factor%2C internal factor%2C on leverage%2C (2 there are the impact of ownership structure %2C external factor%2C internal factor%2C leverage on value of the firm . This study is to examine Agency Theory%2C Jensen and Meckling (1976%2C Pecking Order Theory%2C Myers (1984%2C Trade Off Model and Signaling Theory (1979. Population in this study are public company listed in Jakarta Stock Exchange during 2000 – 2004. As much as 134 firms listed in Jakarta Stock Exchange were taken as a sample using a purposive sampling method.The data were then analyzed by the structural equation modeling ( SEM analysis%2C using the AMOS Program version 4.01.The results of this study show that (1 there are the impact of ownership structure %2C external factor%2C internal factor on leverage%2C(2there are the impact of ownership structure%2C external factor%2C internal factor%2C leverage%2C on valueof the firm . The result of the study is not support the Agency Theory%2C Jensen and Meckling (1976%2C but the result of the study is support Pecking Order Theory%2C Myers (1984%2C Trade off model and Signaling Theory%2C Battacharya (1979. Abstract in Bahasa Indonesia : Tujuan utama dari studi ini adalah untuk menguji pengaruh struktur kepemilikan%2C leverage%2C faktor ekstern%2C dan faktor intern terhadap nilai perusahaan di Bursa Efek Jakarta. Tidak seperti pada permasalahan keagenan di pasar

  10. [Therapeutic effects of internal drainage by expanding arthroscopic gastrocnemius-semimembranosus bursa and cyst wall resection for the treatment of 41 patients with popliteal cysts].

    Science.gov (United States)

    Wu, Li-Chuang; Zhou, Hai-Bo; Zhang, Chao; Chen, Lei; Liu, Cai-Long

    2017-04-25

    To investigate the clinical curative effects of internal drainage by expanding arthroscopic gastrocnemius-semimembranosus bursa(GSB) and cyst wall resection for the treatment of popliteal cysts. A retrospective analysis of patients from May 2011 to December 2015. Arthroscopic treatment for 41 patients with popliteal fossa cysts, 18 males and 23 females, aged from 34 to 67 years old, averaged 42.6 years old. All the patients had preoperative magnetic resonance imagings to confirm the diagnosis and identify the valvular opening(Gastrocnemius-Semimembranosus bursa, GSB), as well as the associated intra-articular pathology. All the popliteal cysts were unilateral, including 26 cases of right knees and 15 cases of left knees. Five patients had recurrent popliteal cysts, and all of them underwent initial open Surgery. The duration from initial surgery to the recurrence ranged from 6 to 17 months(averaged, 11 months). All the patients had underwent arthroscopic treatment of internal drainage by expanding GSB and cyst wall resection. According to the Rauschning and Lindgren classification, 5 cases were grade I , 30 cases were grade II and 6 cases were grade III. Preoperative Lysholm score, 83.19±6.12 (ranged form 73 to 95). The GSB structure was found in all patients with popliteal cysts during operation, including cartilage degeneration in 33 cases, medial meniscus injury in 27 cases, lateral meniscus injury in 7 cases, free body in 8 cases, pigmented villonodular synovitis in 2 cases, and synovial chondromatosis in 3 cases. There were no complications related to vascular, nerve or surgical incision. All the patients were followed up, and the duration ranged from 8 to 27 months, with an average of 18 months. No recurrence of cysts was found. According to the Rauschning and Lindgren classification, there were 9 cases of grade 0, 27 cases of grade I , 4 cases of grade II, 1 case of grade III. Postoperative Lysholm score:91.32±4.26(ranged from 82 to 98). Arthroscopic

  11. Lipoma arborescens: caso raro de ruptura do manguito rotador associado à presença de lipoma arborescens na bursa subacromial-subdeltoidea e glenoumeral Lipoma arborescens: rare case of rotator cuff tear associated with the presence of lipoma arborescens in the subacromial-subdeltoid and glenohumeral bursa

    Directory of Open Access Journals (Sweden)

    Eduardo Benegas

    2012-01-01

    Full Text Available Lipoma arborescens é uma condição rara de moléstia intra-articular, usualmente monoarticular, caracterizada por extensa proliferação dos vilos sinoviais e hiperplasia da gordura subsinovial. O tecido sinovial é progressivamente substituído por células maduras de gordura na membrana sinovial. O presente trabalho é o relato de caso de uma condição rara de lipoma arborescens tanto intra-articular (glenoumeral como da bursa subacromial-subdeltoide além de ruptura do tendão do supraespinhoso. As apresentações clínicas, histológicas e radiográficas assim como o tratamento são discutidos no presente estudo. A apresentação do caso contempla também a avaliação radiográfica, ressonância magnética e exame patológico. Apesar do lipoma arborescens ser uma condição rara, tal hipótese deve ser considerada frente a um caso com hiperproliferação sinovial e lipossubstituição da sinovial.Lipoma arborescens is a rare intra-articular disease that is usually monoarticular and is characterized by extensive proliferation of the synovial villi and hyperplasia of the subsynovial fat. The synovial tissue is progressively replaced by mature fat cells in the synovial membrane. The present study reports a case of a rare condition of lipoma arborescens that was simultaneously intra-articular (glenohumeral joint and in the subacromial-subdeltoid bursa, in association with a torn supraspinatus tendon. The clinical, histological and radiographic presentations and treatment are discussed here. The description of this case includes radiographic and magnetic resonance evaluations and pathological examination. Although lipoma arborescens is a rare condition, it should be taken into consideration in cases presenting synovial hyperproliferation and synovial fat replacement.

  12. [D2 radical resection of omental bursa and No.12p and No.8p for gastric carcinoma: a retrospectively analysis from a single center in China].

    Science.gov (United States)

    Chen, Luchuan; Wei, Shenghong; Ye, Zaisheng; Xiao, Jun; Zeng, Yi; Wang, Yi; Lin, Zhenmeng; Lin, Zhitao; Chen, Xiaoling

    2018-02-25

    To evaluate the safty and feasibility of the D2 radical resection of omental bursa and No.12p and No.8p for gastric carcinoma (GC). Clinical data of 1801 GC patients undergoing D2 radical resection of omental bursa and No.12p and No.8p at Fujian Medical University Cancer Hospital from January 2000 to January 2010 were analyzed retrospectively. Inclusion case criteria: (1)age of 18 to 90 years;(2)pathologically diagnosed as GC and receiving D2 radical resection of omental bursa and No.12p and No.8p;(3)complete clinical, pathological and follow-up data; (4)operation performed by same leading surgeon;(5)exclusion of other gastric malignancies, postoperative relapse of GC, and other simultaneous or heterochronous primary malignancies. Surgical procedure points: (1)The outer part of the peritoneum of duodenum descending was cut; the serosa was migrated to the anterior leaf of the gastrointestinal ligament. (2)The posterior lobe of the gastrocolic ligament and the transverse mesocolon were separated bluntly from left side to reach the omentum attaching to the colon portion; incision was made at the edge of the omentum attaching to the transverse colon behind the gastrocolic ligament; the leaves were turned to the anterior mesenteric anterior leaflets, and the entire anterior leaflet of the transverse mesentery was free.(3)The pancreas was separated, and resection of the posterior wall of the omentum sac continued up so that the entire retinal capsule was free; along the edge of the liver the attachment of the omentum was cut to reach the front of esophagus, and transverse incision was made in abdominal peritoneal layer of the esophagus, and then turned to the spleen on the pole; from the obturator to the esophagus incision was performed behind the peritoneum for the net; the uppermost edge of the resection of the capsule was performed as the posterior peritoneal incision to the right edge of the esophagus and was connected with the posterior parietal lobe of the previous

  13. PENGARUH PROFIT MARGIN, ASSETS TURNOVER DAN LEVERAGE TERHADAP SUSTAINABLE GROWTH RATE PADA PERUSAHAAN SEKTOR JASA YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2010-2012

    Directory of Open Access Journals (Sweden)

    Arim Nasim

    2015-04-01

    Full Text Available This study aims to determine the effect of Profit Margin, Assets Turnover and Leverage on Sustainable Growth Rate. The variables used are profit margin, asset turnover and leverage as independent variable and sustainable growth rate as dependent variable. This study also aims to describe the state of profit margin projected by Net Profit Margin (NPM, asset turnover proxied by Total Assets Turnover (TATO, leverage which is proxied by Debt to Equity Ratio (DER and Sustainable Growth Rate (SGR Service sector. This research was conducted on service sector companies listed in Indonesia Stock Exchange 2010-2012.Data obtained from website Bursa Efek Indonesia.Teknik data analysis used is multiple linear regression and use t-statistics to test the influence of each independent variable to variable Dependent partially.Previously done classical assumption test that includes data normality test, multicolinierity test, heteroskedastisitas test and autocorrelation test.Based on data normality test, multicolinierity test, heteroscedasticity test and autocorrelation test did not found any variables that deviate from the classical assumption.From the results of research Shows that profit margin positively affect sustainable growth rate, asset turnover have positive effect to sustainable growth rate, and leverage have positive effect to sustainable growth rate.

  14. Production of Quality Housing in Urban Transformation in Areas under Disaster Risk: Osmangazi and Yıldırım, Bursa, Turkey

    Directory of Open Access Journals (Sweden)

    Murat Taş

    2014-01-01

    Full Text Available Bursa is one of the cities with high disaster risk and a quality housing problem in Turkey. Urban transformation activities are carried out in order to improve quality of life and create safe living spaces for sustainable urban development. Quality housing production does not signify merely a need to be satisfied quantitatively. Housing and its environment, where physical and social needs of the users are satisfied, should be designed considering local conditions and in a way that they will be suitable for users’ life styles and cultural habits. In this study, the selected study area comprises neighborhoods which are under disaster risk, have been determined as urban transformation areas, and have residents with similar socioeconomic characteristics. With the purpose of improving user satisfaction, this study investigates users’ experience with physical, social, and cultural features of housing and its environment, which identify the quality of housing, and their preferences of new housing units to be produced. Nonprobability sampling method was selected for the field study, and a survey study was conducted. SPSS 17.0 (Statistical Package for Social Sciences was employed for data entry. In order to generate data for quality housing production, relationships between variables were analyzed with Pearson chi-square test.

  15. Use Of New Media In The Local Press: Comparative Analysis Of Local Newspapers Websites In İzmir, Adana and Bursa

    Directory of Open Access Journals (Sweden)

    Berrin Kalsin

    2016-01-01

    Full Text Available Local press is defined as a press that serves to introduce and train the public and to provide the public opinion.  Local press gives information about the cases happen around the region that it is published and it forms public opinion about the problems of that region.  New communication technologies havehave an important role in the forming and enhancing the news contents in the media. Changeovers have occurred in the production,  process and distributiondistribution of the news by developing the new media. On the other hand,  Internet journalism used by many press institutions is occurredoccurred as a new concept in mass communication.  National and local newspapers do not remain insensitive to this new mass communication and it attempts the Internet journalism. Firstly,  pressed newspaper had been turned into Web sites as similar but later new application about the transferring the news to the reader have occurred when we look at this application about the transferring of the pressed newspaper to the Internet environment.  In this study, the Internet websites if Adanaher from Adana,  Olay from Bursa and Ege'nin Sesi from Izmir have been compared with each other.  The form, content and interaction of these three newspapers have been discussed and the usage of social media and importance given to the local news have been analyzed.

  16. Effects of turmeric (Curcuma longa) and vitamin E on histopathological lesions induced in bursa of Fabricius of broiler chicks by salinomycin.

    Science.gov (United States)

    Sayrafi, Reza; Mirzakhani, Navideh; Mobaseri, Reza

    2017-01-01

    The aim of this study was to evaluate the protective effects of the turmeric in comparison to vitamin E on bursal damages induced by salinomycin in broiler chickens. In this study, forty one day-old broiler chicks were randomly divided into four treatment groups: 1- basal diet as control, 2- basal diet plus salinomycin, 3- basal diet plus salinomycin (SLM) and vitamin E (Vit. E) and 4- basal diet plus salinomycin and turmeric powder. The chicks were treated for two weeks. At the end of the experiment, the bursal tissues were removed and fixed in 10% formalin solution. Tissue sections were stained with hematoxylin and eosin stain for histopathological studies. Light microscopic observations showed that, SLM diminished cortex thickness of bursal tissue, enhanced its medulla zone and caused severe lymphocytic necrosis. In addition, SLM led to fibrosis of interstitium along with sever edema of medulla zone in the bursal tissue of the chicken. Administration of Vit. E and TP significantly inhibited the SLM-induced derangements and comparing the Vit. E and TP showed no significant differences. The results of this study indicated that the turmeric may protect bursa of Fabricius against toxicity induced by salinomycin in chicks.

  17. Development of B cells expressing surface immunoglobulin molecules that lack V(D)J-encoded determinants in the avian embryo bursa of fabricius.

    Science.gov (United States)

    Sayegh, C E; Demaries, S L; Iacampo, S; Ratcliffe, M J

    1999-09-14

    Immunoglobulin gene rearrangement in avian B cell precursors generates surface Ig receptors of limited diversity. It has been proposed that specificities encoded by these receptors play a critical role in B lineage development by recognizing endogenous ligands within the bursa of Fabricius. To address this issue directly we have introduced a truncated surface IgM, lacking variable region domains, into developing B precursors by retroviral gene transfer in vivo. Cells expressing this truncated receptor lack endogenous surface IgM, and the low level of endogenous Ig rearrangements that have occurred within this population of cells has not been selected for having a productive reading frame. Such cells proliferate rapidly within bursal epithelial buds of normal morphology. In addition, despite reduced levels of endogenous light chain rearrangement, those light chain rearrangements that have occurred have undergone variable region diversification by gene conversion. Therefore, although surface expression of an Ig receptor is required for bursal colonization and the induction of gene conversion, the specificity encoded by the prediversified receptor is irrelevant and, consequently, there is no obligate ligand for V(D)J-encoded determinants of prediversified avian cell surface IgM receptor.

  18. CbRCI35, a cold responsive peroxidase from Capsella bursa-pastoris regulates reactive oxygen species homeostasis and enhances cold tolerance in tobacco

    Directory of Open Access Journals (Sweden)

    Juan Lin

    2016-10-01

    Full Text Available Low temperature affects gene regulatory networks and alters cellular metabolism to inhibit plant growth. Peroxidases are widely distributed in plants and play a large role in adjusting and controlling reactive oxygen species (ROS homeostasis in response to abiotic stresses such as low temperature. The Rare Cold-Inducible 35 gene from Capsella bursa-pastoris (CbRCI35 belongs to the type III peroxidase family and has been reported to be a cold responsive gene in plants. Here we performed an expressional characterization of CbRCI35 under cold and ionic liquid treatments. The promoter of CbRCI35 was also cloned and its activity was examined using the GUS reporter system. CbRCI35 protein was localized in the cytoplasm according to sequence prediction and GFP fusion assay. Heterologous expression tests revealed that CbRCI35 conferred enhanced resistance to low temperature and activated endogenous cold responsive signaling in tobacco. Furthermore, in the normal condition the ROS accumulation was moderately enhanced while after chilling exposure superoxide dismutase (SOD activity was increased in CbRCI53 transgenic plants. The ROS metabolism related genes expression was altered accordingly. We conclude that CbRCI35 modulates ROS homeostasis and contributes to cold tolerance in plants.

  19. Monocyte targeting and activation by cationic liposomes formulated with a TLR7 agonist

    DEFF Research Database (Denmark)

    Johansen, Pia Thermann; Zucker, Daniel; Parhamifar, Ladan

    2015-01-01

    adaptive immune responses has drawn attention to modulate monocyte responses therapeutically within cancer, inflammation and infectious diseases. We present a technology for targeting of nnonocytes and delivery of a toll-like receptor (TLR) agonist in fresh blood using liposomes with a positively charged...... cytokines. We envision this technology as a promising tool in future cancer immunotherapy....

  20. Asparagine endopeptidase controls anti-influenza virus immune responses through TLR7 activation

    National Research Council Canada - National Science Library

    Maschalidi, Sophia; Hässler, Signe; Blanc, Fany; Sepulveda, Fernando E; Tohme, Mira; Chignard, Michel; van Endert, Peter; Si-Tahar, Mustapha; Descamps, Delphyne; Manoury, Bénédicte

    2012-01-01

    .... Here we report that asparagine endopeptidase (AEP) deficient mice are unable to generate a strong anti-IAV response, as demonstrated by reduced inflammation, cross presentation of cell-associated antigens and priming of CD8...

  1. Plant Virus Particles Carrying Tumour Antigen Activate TLR7 and Induce High Levels of Protective Antibody

    OpenAIRE

    Jantipa Jobsri; Alex Allen; Deepa Rajagopal; Michael Shipton; Kostya Kanyuka; Lomonossoff, George P.; Christian Ottensmeier; Diebold, Sandra S.; Stevenson, Freda K.; Natalia Savelyeva

    2015-01-01

    Induction of potent antibody is the goal of many vaccines targeted against infections or cancer. Modern vaccine designs that use virus-like particles (VLP) have shown efficacy for prophylactic vaccination against virus-associated cancer in the clinic. Here we used plant viral particles (PVP), which are structurally analogous to VLP, coupled to a weak idiotypic (Id) tumour antigen, as a conjugate vaccine to induce antibody against a murine B-cell malignancy. The Id-PVP vaccine incorporates a n...

  2. Thermoresponsive polymer nanoparticles co-deliver RSV F trimers with a TLR-7/8 adjuvant

    Czech Academy of Sciences Publication Activity Database

    Francica, J. R.; Lynn, G. M.; Laga, Richard; Joyce, M. G.; Ruckwardt, T. J.; Morabito, K. M.; Chen, M.; Chaudhuri, R.; Zhang, B.; Sastry, M.; Druz, A.; Ko, K.; Choe, M.; Pechar, Michal; Georgiev, I. S.; Kueltzo, L. A.; Seymour, L. W.; Mascola, J. R.; Kwong, P. D.; Graham, B. S.; Seder, R. A.

    2016-01-01

    Roč. 27, č. 10 (2016), s. 2372-2385 ISSN 1043-1802 R&D Projects: GA ČR(CZ) GJ16-14957Y; GA MŠk(CZ) LQ1604 Institutional support: RVO:61389013 Keywords : thermoresponsive polymers * polymer vaccines * toll-like receptor agonists Subject RIV: CD - Macromolecular Chemistry Impact factor: 4.818, year: 2016

  3. ANALISIS REAKSI PASAR MODAL TERHADAP PENGUMUMAN RIGHT ISSUE DI BURSA EFEK JAKARTA (BEJ (PENGAMATAN TERHADAP RETURN, ABNORMAL RETURN, SECURITY RETURN VARIABILITY DAN TRADING VOLUME ACTIVITY

    Directory of Open Access Journals (Sweden)

    LISTIANA SRI MULATSIH

    2012-05-01

    Full Text Available ABSTRAK   Penelitian ini dilakukan atas dasar pengamatan terhadap kondisi pasar modal Indonesia pada efisiensi bentuk setengah kuat, dimana pasar akan bereaksi terhadap suatu informasi (suatu pengumuman. Jika pengumuman mengandung informasi maka pasar akan bereaksi pada waktu pengumuman diterima pasar. Tujuan penelitian ini adalah untuk mengetahui apakah pasar modal bereaksi terhadap pengumuman right issue, dengan mengamati perilaku return saham, abnormal return, security return variability dan trading volume activity di sekitar tanggal pengumuman (sebelum, saat, sesudah pengumuman. Penelitian ini dilakukan dengan metode event study dengan pendekatan market adjusted model. Sampel penelitian adalah semua perusahaan yang tercatat di Bursa Efek Jakarta, yang mengeluarkan pengumuman right issue saja selama tahun 1999 (24 perusahaan. Uji statistik terhadap return, abonormal return, security return variability dan trading volume activity menggunakan uji t; Paired Two Samples for Mean pada periode sebelum, saat dan sesudah pengumuman right issue. Hasil penelitian untuk return saham menunjukkan perbedaan yang signifikan hanya untuk sebelum dengan saat. Hal ini mengidentifikasikan kemungkinan informasi right issue sudah terserap pada hari-hari sebelum pengumuman dipublikasikan. Abnormal Return dan Security Return Variability tidak menunjukkan perbedaan yang signifikan. Sedangkan Trading Volume Activity menunjukkan perbedaan yang signifikan untuk periode pengamatan sebelum dengan saat dan sesudah dengan sebelum pengumuman. Berdasarkan hasil-hasil peneltiian tersebut dapat disimpulkan bahwa pasar modal tidak bereaksi terhadap pengumuman right issue, sehingga efisiensi pasar modal Indonesia (Bursa Efek Jakarta belum bisa dikategorikan dalam semi strong form. Kata kunci: pasar modal, right issue, return saham, abnormal return, security return variability, trading volume.     ABSTRACT   The research based on the analysis of the observation to the market

  4. Evaluation of the current treatment concepts in Germany, Austria and Switzerland for acute traumatic lesions to the prepatellar and olecranon bursa.

    Science.gov (United States)

    Baumbach, Sebastian F; Domaszewski, Florian; Wyen, Hendrick; Kalcher, Klaudius; Mutschler, Wolf; Kanz, Karl-Georg

    2013-11-01

    Although traumatic lacerations of the olecranon (OB) and praepatellar bursae (PB) are common entities often associated with complications, no study could be found on this injury. The aim of this study was to survey the current treatment concepts for acute traumatic laceration of the OB and PB in Germany, Austria and Switzerland. An international online survey was conducted among orthopaedic and trauma surgeons in Germany (TraumaNetwork DGU), Austria (Austrian Society of Trauma (ÖGU) and Orthopaedic (ÖGO) Surgeons) and Switzerland (Swiss Orthopaedic Surgeons and Swiss Society of Infectious Disease (CH)) (n=1967). The survey comprised of five demographical questions, the current treatment concepts were evaluated using a case study. The overall-response-rate was 16% (12-46%). 88% of the responding physicians were male, aged 47.5 ± 10.2 years with a mean working experience of 20.1 ± 10.6 years. 54% of the surveyed physicians were either senior or chief physicians. Treatment concepts varied significantly between DGU and ÖGO/CH (p=0.02/p=0.006), no significant differences could be found between DGU and ÖGU. Generally, German and Austrian trauma surgeons favoured bursectomy (86.7%/90.9%) and immobilisation (68.3%/77.3%). Austrian orthopaedic surgeons performed fewer bursectomies (69.3%) but had the highest proportion for administering antibiotics (73.9%). Less than 50% of Swiss physicians indicated bursectomy as a treatment option. Overall, this survey revealed a significant heterogeneity in treatment approaches in Central Europe. Further evidence is needed to identify the best treatment concepts for traumatic lacerations of the OB and PB. Copyright © 2012 Elsevier Ltd. All rights reserved.

  5. Ultrasound-guided versus blind subacromial-subdeltoid bursa injection in adults with shoulder pain: A systematic review and meta-analysis.

    Science.gov (United States)

    Wu, Tao; Song, Hai Xin; Dong, Yan; Li, Jian Hua

    2015-12-01

    This systematic review and meta-analysis aimed to assess the effectiveness of ultrasound-guided (USG) versus blind (landmark-guided, LMG) corticosteroid subacromial-subdeltoid bursa injection in adults with shoulder pain. The searches were performed on PubMed, Ovid MEDLINE, Ovid EMBASE, Ovid CochraneCENTRAL, Web of Science, Google Scholar, and Scopus from database inception through March 27, 2015. Studies were included trials comparing USG versus LSG injections for the treatment of adults with subacromial-subdeltoid bursitis. Two reviewers independently performed data extraction and appraisal of the studies. The outcome measures collected were the decreased VAS and SDQ scores, the increased shoulder function scores and shoulder abduction motion range, and the effective rate at 6 weeks after injection. Seven papers including 445 patients were reviewed; 224 received LMG injections and 221 received USG injections. There was a statistically significant difference in favor of USG for pain score [MD = 1.19, 95% CI (0.39, 1.98), P = 0.003] and SDQ score [MD = 5.01, 95% CI (1.82, 8.19), P = 0.02] at 6 weeks after injection. Also there was a statistically significant difference between the groups, with greater improvement reported of shoulder function scores [SMD = 0.89, 95% CI (0.56, 1.23), P < 0.001] and shoulder abduction motion range [MD 32.69, 95% CI (14.82, 50.56), P < 0.001] in the USG group. More effective rate was also reported with USG group and the difference was statistically significant [risk ratio = 1.6, 95% CI (1.02, 2.50), P = 0.04]. Ultrasound-guided corticosteroid injections potentially offer a significantly greater clinical improvement over blind SASD bursitis injections in adults with shoulder pain. Copyright © 2015. Published by Elsevier Inc.

  6. EFFECT OF ANTANAN (CENTELLA ASIATICA AND VITAMIN C ON THE BURSA OF FABRICIUS, LIVER MALONALDEHIDE AND PERFORMANCE OF HEAT-STRESSED BROILERS

    Directory of Open Access Journals (Sweden)

    REVIANY WlDJAJAKUSUMA

    2005-01-01

    Full Text Available High environmental temperatures may cause heat stress in poultry. This may increase water consumption, decrease feed consumption and in rum, decrease productivity level. In addition, high temperature contributes to oxidative stress, a condition where oxidant activity (free radica ls exceeds antioxidant activity. In our research, antanan (Centelta asiatica and vitamin C were utilized as anti heat-stress agents for heat-stressed broilers. We used 120 male broilers 2 - 6 weeks old, kept at 31.98 ± 1.94 °C during the day and 27.36 ± 1.31 °C at night. The data collected were analyzed with a completely randomized factorial design of 2 x 3 (2 levels of vitamin C, 3 levels of antanan at 4 replications and continued with the contrast-orthogonal test when significantly different. The results indicate that the treatments of 5 and 10% of antanan with or without 500 ppm of vitamin C and vitamin C alone significantly (P<0.05 decreased the heterophil/lymphocyte (H/L ratio and liver malonaldchydc (MDA. These treatments, however, significantly (P<0.05 increased the bursa of Fabricius weight, feed consumption and body weight gain. It could be concluded that basal ration administered with 5% antanan and 500 ppm vitamin C could effectively prevent broilers from heat stress. The results support the conclusion that a ba sal ration supplemented with 5% antanan and 500 ppm of vitamin C or their combinations, effectiv elly reduces heat stress in broilers.

  7. Targeted knockout of TNF-α by injection of lentivirus-mediated siRNA into the subacromial bursa for the treatment of subacromial bursitis in rats.

    Science.gov (United States)

    Wang, Yi; Li, Quan; Wei, Xianzhao; Xu, Jie; Chen, Qi; Song, Shuang; Lu, Zhe; Wang, Zimin

    2015-09-01

    Subacromial bursitis (SAB) is the major source of pain in rotator cuff disease. Although multiple investigations have provided support for the role of inflammatory cytokines in SAB, few have focussed on the use these cytokines in the treatment of SAB. The aim of the present study was to observe the therapeutic efficacy of lentivirus‑mediated RNA interference (RNAi) on carrageenan‑induced SAB by injecting lentivirus‑tumor necrosis factor (TNF)‑α‑RNAi expressing TNF‑α small interfering (si)RNA. Using screened siRNA segments, an siRNA was designed. A lentivirus vector expressing siRNA was established and packed as lentivirus particles. A lentivirus that expressed the negative sequence was used as a lentivirus‑negative control (NC). The carrageenan‑induced SAB model was established in 32 male Sprague‑Dawley rats. The modeled rats were randomly assigned to four groups: Lentivirus‑RNAi treatment group, lentivirus‑NC group, SAB group and phosphate‑buffered saline (PBS) blank control group. The lentivirus was injected (1x10(7) transducing units) into the subacromial bursa of the rats in the lentivirus‑RNAi group and lentivirus‑NC group, whereas 100 µl PBS was injected at the same site in the SAB group and the PBS blank control group. At 5 weeks following injection, the animals were sacrificed and venous blood was obtained. The effect of TNF‑α interference and the expression of inflammatory cytokines were determined by reverse transcription‑quantitative polymerase chain reaction, western blotting, hematoxylin and eosin staining, Van Gieson's staining and immunofluorescence. The expression of TNF‑α was decreased in the lentivirus‑TNF‑α‑RNAi group compared with that in the SAB group. Morphological observations revealed that the number of inflammatory cells were reduced and damage to tendon fibers was attenuated in this group, suggesting that the downregulation of the protein expression levels of TNF‑α‑associated nuclear

  8. The role of the bursa of Fabricius in the immune response to vaccinal antigens and the development of immune tolerance in chicks (Gallus domesticus) vaccinated at a very young age.

    Science.gov (United States)

    Ifrah, M E; Perelman, B; Finger, A; Uni, Z

    2017-01-01

    Vaccination is recognized to be the most cost-effective means of preventing, controlling, and even eradicating infectious diseases. Conventional poultry are vaccinated through various routes including eye/nose drops, drinking water, vent brush, or injection. Efficient vaccination is an essential part of any good poultry management.The bursa of Fabricius is intimately connected to the cloaca and the intestinal system. It is well-known as a primary lymphoid organ in the chicken and a major channel through which environmental antigens stimulate the immune system. In this study we tested whether direct instillation of various viral vaccines and antigens into the cloaca (per bursam), could stimulate higher antibody titers and generate improved protection. Despite the very rapid absorption of the vaccines or antigens from the cloaca to the lumen of the Bursa of Fabricius, per bursam inoculation failed to generate a satisfactory immune response. In contrast conventional administration of live or inactivated commercial vaccines led to an acceptable level of seroconversion and protection against challenge.An interesting finding in this study was the fact that administration of a single priming dose of antigenic material at age 1 or 5 days, did not improve the response to a second administration at 14 days of age as expected. Instead, in most cases there was a reduced serum antibody response suggesting the induction of tolerance. This was true for all routes of administration (intramuscular, per ocular and per bursam) and for all formulations of vaccine.The current study reveals: 1) no advantage for direct application of live or inactivated vaccines or antigens into the bursa of Fabricius compared to common routes of vaccination, 2) that apparent desensitization or tolerance effects have important implications for poultry management, since in many countries, vaccination of day old chicks is compulsory or a well-accepted part of flock vaccination.According to our results

  9. Bursa ilinde sanayie yönelik sözleşmeli sebze üreten tarım işletmelerinin ve sebze işleme sanayinin ekonomik analizi

    OpenAIRE

    Güneş, Erdoğan

    1999-01-01

       Bu çalışmada, sözleşmeli sete» üretiminin ve özellikle domates yetiştiriciliğinin yogan olarak yaprağı Bursa ili; Karacabey, Mustafakemalpaşa ve Yenişehir ilçelerindeki taran işletmeleri ve sebze işleme firmalarının faaliyetleri incelenmiştir. Araştırma kapsamında ele alman 120 tarım işletmesi, tabakalı tesadüfi örnekleme yöntemi ite belirlenirken, sanayi işletmelerinin seçiminde tam sayım yöntemi kullanılmıştır. Araştırma kapsamında ele alınan tarım ...

  10. Etude comparative de l’absorption de l’azote par deux espèces d’algues rouges : (Hudson) papenfuss, 1950 et Gracilaria <Bursa-pastoris> (gmelin) silva, 1952.

    OpenAIRE

    Romdhane, M.S.; Chebil-Ajjabi, L.; El Abed, A.

    2005-01-01

    Afin de mettre en évidence l’aptitude de deux espèces d’algues rouges Gracilaria verrucosa et Gracilaria bursa-pastoris pour le traitement des effluents et leur utilisation potentielle, une série d’expériences a été réalisée ayant pour but d’expliquer le comportement de ces deux espèces d’algues vis à vis de la source d’azote. Dans une première expérience, on a pu déterminer la forme d’azote (N-NH4 , N-NO3) preférentielle pour chacune des deux espèces d’algues cultivées séparément. Elles ...

  11. Ação trófica de aditivos fitogênicos, glutamina e ácido glutâmico sobre a Bursa de Fabrícius e intestino delgado de frangos de corte

    Directory of Open Access Journals (Sweden)

    Vanessa Cristina Pelícia

    2015-07-01

    Full Text Available Abstract The aim of this study was to evaluate the effect of phytogenic additives and glutamine plus glutamic acid, associated or not, on histomorphometry of bursa of Fabricius and small intestine, oocyst count and lesion scores, and carbon turnover of duodenal mucosa of broiler chickens infected with Eimeria acervulina. A total of 450 male broiler chickens was distributed into a completely randomized design with six treatments and three replications. Treatments consisted of control diet (CD; CD + coccidiosis vaccine; CD + antibiotic performance enhancers and anticoccidial (APE/AC; CD + glutamine and glutamic acid (Gln/Glu; CD + phytogenic additives (PA; CD + Gln/Glu + PA. Birds on treatment CD + vaccine were vaccinated via drinking water at three days of age against coccidiosis. At 16 days of age all birds of all treatments were inoculated orally and individually with 500,000 oocysts of Eimeria acervulina. There was no treatment effect on lesion score in the intestinal epithelium of birds. The smaller number of excreted oocysts was observed in groups of birds fed diets containing APE/AC and PA. Were observed better results of villus height and crypt depth for duodenum and ileum of birds of treatments containing Gln/Glu at 7 days of age, and Gln/Glu and PA at 21 days of age. Higher percentage of cortical area from bursa follicles was observed in birds fed diets supplemented with Gln/Glu and PA at 7, 14 and 21 days of age. Increased turnover of intestinal mucosa was observed in treatments containing Gln/Glu, indicating acceleration in development and regeneration of damaged tissue. Glutamine plus glutamic acid and phytogenic additives can provide improvements to structure, and thus to intestinal function, as well as to better immune response against the infectious challenges. Phytogenic additives can be used for coccidiosis control of broiler chickens where the use of antibiotic performance enhancers and anticoccidials is prohibited.

  12. Belediyelerin Raylı Ulaşım Hizmetlerinin Yaygınlaştırılması: Bursa Büyükşehir Belediyesi Örneği

    Directory of Open Access Journals (Sweden)

    Harun KILICASLAN

    2015-12-01

    Full Text Available Rail services for which substantial investment required can be provided only in cities with a certain population size. However, if a city does not have a sufficient potential for passengers to cover the operating costs, such service may not be offered. In particular, lowering the cost of rail vehicles can lead to applications in less populated cities. The purpose of this study was the investigation of encouraging domestic production, as a tool to reduce rail vehicle costs, and in the context of the relations of municipalities between central government and private sector within the framework of the public economy. For this purpose, the applications and rail transportation services of Bursa Metropolitan Municipality are discussed as examples. Büyük ölçekli yatırım gerektiren kentsel raylı ulaşım hizmetleri maliyet koşulları nedeniyle sadece belli bir nüfus büyüklüğüne sahip kentlerde sunulabilmektedir. Bununla beraber işletme giderlerini karşılamaya yetecek kadar yolcu potansiyeline sahip olmayan kentlerde söz konusu hizmet sunulamamaktadır. Özellikle araç maliyetlerinin düşürülmesi raylı sistem uygulamalarını daha az nüfuslu kentlerde de uygulanabilir duruma getirebilecektir. Araç maliyetlerinin düşürülebilmesinin bir yolu olarak yerli üretimin teşvik edilmesi ve bu bağlamda belediye ve merkezî idare ile özel kesimin rollerinin kamu ekonomisi çerçevesinde irdelenmesi bu çalışmanın amacını oluşturmuştur. Bu amaçla örnek olarak Bursa Büyükşehir Belediyesi’nin uygulamaları ve raylı ulaşım hizmetleri ele alınmıştır.

  13. [Analysis of effects of arthroscopic treatment for recurrent patellar dislocation by lateral patellar retinacular release outside the synovial bursa of knee joint combined with reconstruction of medial patellofemoral ligament].

    Science.gov (United States)

    Li, Bei; Tan, Jian-yi; Zeng, Zhi-bin; Zhan, Tie-jun; Chen, Hai-qiang

    2015-07-01

    To introduce an arthroscopic technique in managing recurrent dislocation of the patella and its clinical results. Sixteen patients with recurrent patellar dislocation were reviewed, including 3 males and 13 females. The average age was 17.6 years old (ranged from 14 to 32 years). The patients suffering from patellar sub-luxation averaged 18.5 months (ranged from 6 to 23 months)before operation. These patients were treated with lateral patellar retinacular release outside the synovial bursa of knee joint and medial patellofemoral ligament reconstruction using the semitendinosus tendon free autograft. The Lyshohm scores before and after operation were used to evaluate outcomes at the final follow-up. All the patients were followed up, and the duration ranged from 6 to 48 months, with an average of 12 months. There was no recurrence. The Q angle decreased from (16.4 ± 3.7)° to (10.1 ± 1.4)°; insall index decreased from 1.37 ± 0.25 to 1.28 ± 0.23; congruence angle decreased from (21.3 ± 2.6)° to (5.86 ± 2.23)°; Lysholm score improved from 76.1 ± 5.2 to 89.8 ± 4.1 at 6 months after operation. Compared with conventional procedure, arthroscopic surgery for recurrent dislocation of the patella achieves excellent outcomes with minimum invasion.

  14. Adsorption of a synthetic TLR7/8 ligand to aluminum oxyhydroxide for enhanced vaccine adjuvant activity: A formulation approach

    OpenAIRE

    Fox, Christopher B.; Orr, Mark T.; Van Hoeven, Neal; Parker, Sarah C.; Mikasa, Traci J.T.; Phan, Tony; Beebe, Elyse A.; Nana, Ghislain I.; Joshi, Sharvari W; Tomai, Mark A.; Elvecrog, James; Fouts, Timothy R.; Reed, Steven G.

    2016-01-01

    For nearly a century, aluminum salts have been the most widely used vaccine adjuvant formulation, and have thus established a history of safety and efficacy. Nevertheless, for extremely challenging disease targets such as tuberculosis or HIV, the adjuvant activity of aluminum salts may not be potent enough to achieve protective efficacy. Adsorption of TLR ligands to aluminum salts facilitates enhanced adjuvant activity, such as in the human papilloma virus vaccine Cervarix?. However, some TLR...

  15. Analisis Responsivitas Bursa Syariah oleh Variable Makroekonomi

    Directory of Open Access Journals (Sweden)

    Yoghi Citra Pratama

    2015-10-01

    Full Text Available The objective of this study is to analyze the stock response because of M2, exchange rate (rupiah to US dollar, and rate of SBI. The data used in this study is monthly time series data from January 2006 until May 2012. Those variables are JII, M2, exchange rate rupiah to US dollar, and rate of SBI. Research method used in this study is Vector Error Correction Model (VECM. The cointegration test indicates that among research variables there is long term equilibrium and simultaneous relationship. The empirical result of impulse response show that the effect of SBI rate and M2 are negative and the effect of exchange rat is positive. The result on variance decomposition test, show that the most effect of JII shock is influenced by JII itself.DOI: 10.15408/aiq.v4i2.2100

  16. Apoptose e expressão de VP2 e GAPDH na infecção precoce pelo vírus da doença infecciosa da bursa de Fabricius em pintos SPF Apoptosis and expression of VP2 and GADPH in an experimental infectious bursal disease in SPF chicks

    Directory of Open Access Journals (Sweden)

    J.J. Batista

    2007-04-01

    Full Text Available Vinte e nove pintos SPF de um dia foram inoculados com o vírus da doença infecciosa da bursa de Fabricius (VDIB para avaliar a ocorrência precoce de apoptose e a expressão da proteína viral 2 (VP2 e da enzima gliceraldeído fosfato dehidrogenase (GAPDH. Os animais foram distribuídos em cinco grupos: 1-controle; e 2 a 5- com 24, 48, 72 e 96 horas pós-inoculação, respectivamente. Fragmentos da bursa de Fabricius foram colhidos para processamento histológico e extração de RNA. Lâminas coradas em HE e TUNEL (marcação in situ da fragmentação do genoma com transferase terminal de deoxinucleotídeo foram utilizadas na morfometria do índice apoptótico. Amostras de mRNA foram testadas para a expressão dos genes VP2 e GAPDH utilizando-se transcrição reversa e RT-PCR. Utilizou-se um kit SYBR GREEN PCR, e a reação foi desenvolvida em ABI Prism 7000 SDS. Os índices apoptóticos cresceram progressivamente indicando uma relação na atrofia bursal causada pelo VDIB. Paralelamente, os resultados da PCR em tempo real demonstraram queda da carga viral nas células linfóides da bursa nos diferentes intervalos de tempo do experimento. Esses resultados sugerem um papel protetor da apoptose na diminuição da replicação viral.Twenty-nine SPF 1-day-old chicks were inoculated with infectious bursal disease virus (IBDV to evaluate early apoptosis and the expression of viral protein 2 (VP2 and glyceraldehyde-3-phosphate dehydrogenease (GAPDH. Five groups were formed: G1-control -and G2 to G5, - 24, 48, 72 and 96 hours post inoculation, respectively. Half of each BF was fixed and processed by routine techniques. To quantify apoptosis, 5µm-thick sections were stained with HE and submitted to TUNEL (terminal transferase UDP nick end labeling technique. mRNA was extracted from pooled samples of 3 animals/group and used for the expression of VP2 and GADPH genes using the reverse transcription and real-time polymerase chain reaction (RT-PCR. A SYBR

  17. Analisis Pengaruh Indeks Bursa Saham Asing Dan Kurs Dolar Amerika Serikat Terhadap Indeks Bursa Efek Indonesia

    OpenAIRE

    Siregar, Adlin Syahputra Angkasa

    2011-01-01

    Examining the development of the Indonesia Stock Exchange is an interesting and challenging since the government removed the foreign ownership limit on the Indonesia Stock Exchange September 1997. In relative terms, the amount of factors influence the foreign stock market indices of the development of a stock shows the stock level of integration with world capital markets. Stock markets are more integrated with world capital markets, which are more influenced by foreign factors, the potential...

  18. First-Line Therapy for Human Cutaneous Leishmaniasis in Peru Using the TLR7 Agonist Imiquimod in Combination with Pentavalent Antimony

    Science.gov (United States)

    Miranda-Verastegui, Cesar; Tulliano, GianFranco; Gyorkos, Theresa W.; Calderon, Wessmark; Rahme, Elham; Ward, Brian; Cruz, Maria; Llanos-Cuentas, Alejandro; Matlashewski, Greg

    2009-01-01

    Background Current therapies for cutaneous leishmaniasis are limited by poor efficacy, long-term course of treatment, and the development of resistance. We evaluated if pentavalent antimony (an anti-parasitic drug) combined with imiquimod (an immunomodulator) was more effective than pentavalent antimony alone in patients who had not previously been treated. Methods A randomized double-blind clinical trial involving 80 cutaneous leishmaniasis patients was conducted in Peru. The study subjects were recruited in Lima and Cusco (20 experimental and 20 control subjects at each site). Experimental arm: Standard dose of pentavalent antimony plus 5% imiquimod cream applied to each lesion three times per week for 20 days. Control arm: Standard dose of pentavalent antimony plus placebo (vehicle cream) applied as above. The primary outcome was cure defined as complete re-epithelization with no inflammation assessed during the 12 months post-treatment period. Results Of the 80 subjects enrolled, 75 completed the study. The overall cure rate at the 12-month follow-up for the intention-to-treat analysis was 75% (30/40) in the experimental arm and 58% (23/40) in the control arm (p = 0.098). Subgroup analyses suggested that combination treatment benefits were most often observed at the Cusco site, where L. braziliensis is the prevalent species. Over the study period, only one adverse event (rash) was recorded, in the experimental arm. Conclusion The combination treatment of imiquimod plus pentavalent antimony performed better than placebo plus pentavalent antimony, but the difference was not statistically significant. Trial Registration Clinical Trials.gov NCT00257530 PMID:19636365

  19. First-line therapy for human cutaneous leishmaniasis in Peru using the TLR7 agonist imiquimod in combination with pentavalent antimony.

    Directory of Open Access Journals (Sweden)

    Cesar Miranda-Verastegui

    2009-07-01

    Full Text Available Current therapies for cutaneous leishmaniasis are limited by poor efficacy, long-term course of treatment, and the development of resistance. We evaluated if pentavalent antimony (an anti-parasitic drug combined with imiquimod (an immunomodulator was more effective than pentavalent antimony alone in patients who had not previously been treated.A randomized double-blind clinical trial involving 80 cutaneous leishmaniasis patients was conducted in Peru. The study subjects were recruited in Lima and Cusco (20 experimental and 20 control subjects at each site. Experimental arm: Standard dose of pentavalent antimony plus 5% imiquimod cream applied to each lesion three times per week for 20 days. Control arm: Standard dose of pentavalent antimony plus placebo (vehicle cream applied as above. The primary outcome was cure defined as complete re-epithelization with no inflammation assessed during the 12 months post-treatment period.Of the 80 subjects enrolled, 75 completed the study. The overall cure rate at the 12-month follow-up for the intention-to-treat analysis was 75% (30/40 in the experimental arm and 58% (23/40 in the control arm (p = 0.098. Subgroup analyses suggested that combination treatment benefits were most often observed at the Cusco site, where L. braziliensis is the prevalent species. Over the study period, only one adverse event (rash was recorded, in the experimental arm.The combination treatment of imiquimod plus pentavalent antimony performed better than placebo plus pentavalent antimony, but the difference was not statistically significant.Clinical Trials.gov NCT00257530.

  20. DAYA TARIK PASAR MODAL ISLAMI: STUDI DI BURSA EFEK INDONESIA

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    Zaenal Arifin

    2017-03-01

    Full Text Available Islamic capital market was a capital market in which the stock issuer’s business and the trading mechanismwere both Islamic. Islamic corporate issuers were already selected in Islamic stock index while Islamic trademechanism had to meet the requirements to avoid speculation (gharar. Some experts had proposed a model ofan Islamic stock trading such as Metwally (1992 and Chapra (1992. The question was if the islamic modelwas applied, “was the stock market still interesting?” This study wanted to answer that question. By using asample of companies in Jakarta Islamic Index (JII from 2007 to 2013 this study showed the following results.Metwally model proved to be very attractive because it generated a return (capital gain at least equal to realcapital markets and the risk of capital loss was smaller. But investors should be careful because the standarddeviation of return among stock in this stock market model was relatively high. Meanwhile, the Chapra modelgave investors not only a lower risk but also lower returns. The performance of Chapra Islamic capital marketmodel had not been conclusive because when using Sharpe index and Jensen index, the performance indexdecreased but when using the Treynor index, the performance did not decrease.

  1. Bond Ratings dan Antesedennya: Studi Empiris di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Wendy Wendy

    2017-01-01

    Full Text Available This paper provides the empirical evidence of corporate growth, maturity, and operating cash flows on the bond ratings. It was conducted on 34 bonds issued by the 16 non-financial companies on the Indonesia Stock Exchange (IDX which also issued bonds, registered in the Indonesia Bond Market Directory, and rated by PEFINDO during 2012 - 2014. The hypotheses were tested using the logistic regression analysis. The result shows that corporate growth has significant effect on the bond ratings, while maturity and operating cash flow have no significant effect. Another finding shows that the firm size can also affect the bond ratings.

  2. Hubungan Volatilitas dan Volume Perdagangan di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Bambang Sutrisno

    2017-02-01

    Full Text Available The Relationship Between Volatility and Trading Volume in The Indonesian Stock ExchangeThere are a lot of studies that examine the relationship between volatility and trading volume in the stock exchange. This study is conducted to examine the role of trading frequency and volume in explaining the volatility-volume relationship in the Indonesia Stock Exchange (IDX. The analysis is conducted at the firm level with samples of 38 individual stocks from January 2012 to December 2013. The results show that there is a positive relationship between volatility and trading frequency as well as between volatility and trading volume. The results also find that trading frequency is better than trading volume in explaining volatility.DOI:  10.15408/ess.v7i1.3894  

  3. Direct Financial Market: Islamic Equity Market (Bursa Saham dalam Islam)

    OpenAIRE

    Timorita Yulianti, Rahmani

    2010-01-01

    Islamic capital market is developed in order to accommodate the needs of Muslims in Indonesia who wish to invest in the instrument of capital-market instruments in accordance with Islamic principles. The industrial sector is expected to accommodate the capital market and also involves the participation of Muslim citizens to take active steps directly into the main market actors, principles. The industrial sector is expected to accommodate the capital market an...

  4. Mosses beta radioactivity in Katirli mountain-Bursa, TURKEY

    Science.gov (United States)

    Kahraman, A. G.; Kaynak, G.; Akkaya, G.; Gultekin, A.; Gurler, O.; Yalcin, S.

    2007-04-01

    Mosses are one of the most widely used procedures to determine via plant of radioactive contamination. The high concentrating capacity of mosses may be used as bioindicator of environmental radioactive contamination. In this study, the mosses were collected in region of Katirli Mountain in northwestern Turkey, activities were determined using TENNELEC LB 1000-PW detector. Samples of mosses growing on soil, rock, and tree bark were collected.

  5. Prediksi Financial Distress Pada Perusahaan Manufaktur Di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Randy Kurnia Permana

    2017-06-01

    Full Text Available Financial Distress Prediction in Manufacturing Companies at Indonesian Stock ExchangeThis study aims to identify, analyze, demonstrate and test the differences in health status between the model results Grover, Springate, and Zmijewski. The model used by investors who will invest in the company. This study has a characteristic that is tested three models and find the one best model. Data was tested using chi-square test. Results showed Hypothesis 1 accepted that there are differences in health status in the test model of Grover, Springate, and Zmijewski on manufacturing companies listed on the Stock Exchange 2006-2015. Model Springate is the best predictive model than the model Grover and Springate, because it has more components than the other models and models Springate have EBIT  To Current Liabilities component is how much profit the ability to pay debts. This component is a very important component to see financial distress, due to financial distress occur because one debt that not covered by the companyDOI: 10.15408/ess.v7i2.4797

  6. ANALISIS KONTRAK BERJANGKA OLEIN DI BURSA BERJANGKA JAKARTA

    Directory of Open Access Journals (Sweden)

    Andam Dewi

    2011-09-01

    Full Text Available Normal 0 false false false MicrosoftInternetExplorer4 st1\\:*{behavior:url(#ieooui } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Study about efficient market hypothesis is a common object for many financial researchers. Nevertheless, there are still limited studies about futures contract market particularly in the emerging market. The purposes of this study were to test the weak form efficiency of the Olein futures contract in the Jakarta Futures Exchange and to seek factors that can affect the fluctuation of Olein futures contract price. ARIMA and GARCH models were used as the basis for the analyses. Results of the study indicated that using weekly data, the weak form efficient market (random walk hypothesis was rejected for the Olein futures contract in the Jakarta Futures Exchange, meaning that the market was in efficient.This implies that some one will be able to outperform the market using technical analysis for predicting future price changes. Furthermore, using monthly data, the fluctuation of Olein futures contract returnis influenced significantly by interest rate, exchange rate and CPO price.   Keywords : Jakarta Futures Exchange, Efficient Market Hypothesis, ARIMA, GARCH

  7. Determinan Struktur Modal pada Perusahaan Menufaktur di Bursa Efek Indonesia

    OpenAIRE

    Yulianto, Agung

    2011-01-01

    Financing resource is very important to support firm activities. A number of theories have been proposed to explain the variation in debt ratios across firms. The theoris suggest that frims select capital structure depending on attributes that determine the various costs and benefits associated with debt and equite financing. Financial managers often think of the frim´s debt-equite decision as a trade-off between interesed tax shields and the cost of financial distress. This packing order the...

  8. Faktor-Faktor yang Mempengaruhi Nilai Perusahaan pada Perusahaan yang Terdaftar di Bursa Efek Malaysia dan Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Sri Hermuningsih

    2011-03-01

    Full Text Available The objective of this study was proving the influences of insider ownership, debt policy and dividend policy to firm value at companies listed in Malaysia Stock Exchange and Indonesia Stock Exchange during 2003 to 2008. This study used multistage regression to reach the objective. The results indicate that in Malaysia, insider ownership and debt policy have an effect to dividend policy but have not a significant effect to firm value and in Indonesia, insider ownership and debt policy have not an effect to dividend policy and dividen policy also not have an effect to company value. Beside that the Malaysian and Indonesia investors do not use a dividend policy as a positif signal because many firms give dividend although they have not profit. Keywords: insider ownership, debt policy, dividend policy, firm value

  9. VALUE RELEVANCE DAN IFRS ADOPTION DI INDONESIA: INVESTIGASI PADA PERUSAHAAN LQ-45 BURSA EFEK INDONESIA

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    Triandi ,

    2017-02-01

    Full Text Available Value relevance is being defined as the ability of information disclosed by financial statements to capture and summarize firm value. earnings per share (EPS and book value of shares (BVS and stock market price (SMP, both before and after IFRS adoption. Based on theresult,test there the valuerelevancebefore and after IFRS adoptio. The value relevance after IFRS adoption decreased. These findings differ from the findings in several countries have adopted IFRS. In many countries have adopted IFRS tends to increase the value relevance. Keyword : value relevance, earning per share, book value of equity, stock price, IFRS adoption, LQ-45

  10. Spatiotemporal Change Detection Using Landsat Imagery: the Case Study of Karacabey Flooded Forest, Bursa, Turkey

    Science.gov (United States)

    Akay, A. E.; Gencal, B.; Taş, İ.

    2017-11-01

    This short paper aims to detect spatiotemporal detection of land use/land cover change within Karacabey Flooded Forest region. Change detection analysis applied to Landsat 5 TM images representing July 2000 and a Landsat 8 OLI representing June 2017. Various image processing tools were implemented using ERDAS 9.2, ArcGIS 10.4.1, and ENVI programs to conduct spatiotemporal change detection over these two images such as band selection, corrections, subset, classification, recoding, accuracy assessment, and change detection analysis. Image classification revealed that there are five significant land use/land cover types, including forest, flooded forest, swamp, water, and other lands (i.e. agriculture, sand, roads, settlement, and open areas). The results indicated that there was increase in flooded forest, water, and other lands, while the cover of forest and swamp decreased.

  11. Pengaruh Good Corporate Governance Terhadap Kinerja Keuangan pada Perusahaan Perkebunan yang Terdaftar di Bursa Efek Indonesia

    OpenAIRE

    Nasution, Hernita

    2015-01-01

    This research aims to know whether good corporate governance affect to the financial performance of plantation companies were listed on the Indonesia Stock Exchange (IDX). The independent variables consist of board of commissioners, board of directors, nomination and remuneration committee, and risk management committee. Dependent variable is financial performance as measured by Return On Assets (ROA). The method used to analyst data for this research is quantitative method with do testin...

  12. PENGARUH STOCK SPLIT TERHADAP LIKUIDITAS DAN RETURN SAHAM DI BURSA EFEK JAKARTA

    Directory of Open Access Journals (Sweden)

    Wang Sutrisno

    2000-01-01

    Full Text Available Research on stock splits has frequently been undertaken. The results vary, but fundamentally can be classified into two groups. First, the stock split is purely "cosmetic". Second, the stock split has a real effect on stocks. The difference between these opinions raises controversy. The purpose of this study is to examine whether stock splits influence stock liquidity and return of an individual stock as well as in a group of stocks as a portfolio. Overall, the results of this study show that stock splits did influence stock price, trading volume and bid-ask spread but did not influence stock risk and abnormal return from the point of view of an individual stock as well as in a group of stocks as a portfolio. The test of a relationship between bid-ask spread and stock price, trading volume and stock risk for each stock shows that all three variable did not significantly affect the bid-ask spread. On the other hand, the test of a relationship in a portfolio reveals that only stock prices significantly affect the bid-ask spread. Abstract in Bahasa Indonesia : Penelitian mengenai stock split sudah sering dilakukan. Hasil dari penelitian- penelitian tersebut bermacam - macam, tetapi pada dasarnya dapat dibedakan menjadi dua kelompok. Pertama, stock split dinyatakan murni hanya sebagai "kosmetik". Kedua, stock split dinyatakan mempunyai efek yang nyata terhadap saham. Perbedaan pendapat ini sering menimbulkan kontroversi. Tujuan dari penelitian ini adalah untuk menguji kembali apakah betul stock split dapat mempengaruhi likuiditas dan return saham baik ditinjau secara individual untuk masing - masing saham maupun seluruh saham sebagai sebuah portofolio. Secara keseluruhan, hasil dari penelitian ini menunjukkan bahwa stock split hanya mempengaruhi harga, volume perdagangan dan persentase spread, tetapi tidak mempengaruhi varians dan abnormal return baik ditinjau secara individual maupun sebagai sebuah portofolio. Sedangkan pengujian hubungan antara persentase spread terhadap harga, volume, dan varians untuk masing - masing saham menunjukkan bahwa ketiga variabel tersebut tidak berpengaruh secara signifikan terhadap spread. Sebaliknya, jika ditinjau sebagai sebuah portofolio, hanya harga yang mempunyai pengaruh yang signifikan terhadap spread. Kata kunci: stock split, likuiditas, abnormal return, bid - ask spread, return saham

  13. Relevansi Nilai Modal Intelektual Terhadap Nilai Pasar Perusahaan di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Akbar yusuf

    2015-08-01

    Full Text Available The purpose of this study was to test the direct and moderation relationship between intellectual capital and components with market value. This study analyzed secondary data available at the Indonesia Stock Exchange in 2008-2012, using multiple linier regression analysis techniques and moderation. Four factors are used to reduce bias control models of the Leverage (DEBT, Size, R&D expenditure, and Advertising expenditure. The result is intellectual capital and its components have the relevant value with market value. The presence of R&D expenditure increase its market value. Interaction human capital and structural capital provides relevant value to market value, but negatively.

  14. PERENCANAAN PENYALURAN TENAGA KERJA OLEH BURSA KERJA KHUSUS (BKK SMK MIGAS CEPU

    Directory of Open Access Journals (Sweden)

    Aldila Prajamudi Karaning Utami

    2014-11-01

    Full Text Available Metode penelitiaan yang digunakan adalah kualitatif. Teknik pengumpulan data yang digunakan observasi, wawancara dan dokumentasi. Teknik analisis data menggunakan teknik deskriptif kualitatif. Hasil penelitian pada pertanyaan pertama yaitu proses identifikasi lowongan pekerjaan, dalam proses identifikasi tersebut terdapat beberapa perusahaan mitra BKK meliputi bidang teknik dan industri, jasa dan niaga. Kemudian fasilitas-fasilitas pelayanan yang disediakan BKK terdiri dari: (1 Pusat Informasi Lowongan Pekerjan, (2 Blog/Web Khusus Alumni SMK MIGAS, (3 Brosur Lowongan Pekerjaan, (4 Bimbingan Karir dan Analisis Jabatan. Sedangkan teknik atau/metode yang digunakan dalam pemasaran lulusan meliputi beberapa segi, diantaranya yaitu: (1 Segi pengelolaan BKK, (2 Segi pengelolaan calon alumni, (3 Segi pengelolaan DU/DI, (4 Segi pengelolaan kemitraan. Terakhir adalah prosedur/tahapan dalam penyaluran dan penempatan tenaga kerja, dilihat dari prosesnya BKK terdiri dari 3 kegiatan inti yaitu (1 pemetaan (alumni/lulusan dan DU/DI, (2 penyaluran alumni/lulusan, dan (3 jalinan kerjasama dengan pihak DU/DI. Berdasarkan hasil penelitian di atas, dapat disimpulkan bahwa ada bebrapa kegiatan BKK yang berkaitan dengan penyaluran tenaga kerja. Beberapa hal meliputi Proses identifikasi lowongan pekerjaan, Fasilitas-fasilitas pelayanan dalam rangka memberikan informasi tentang lowongan pekerjaan/dunia kerja, Teknik/metode BKK untuk memasarkan lulusannya, Prosedur/tahapan dalam penyaluran dan penempatan tenaga kerja merupakan hal-hal yang sangat mempengaruhi proses perencanaan penyaluran tenaga kerja. The results of research on the first question, namely the identification of a job, in the identification process, there are several companies BKK partners include engineering and industry, services and commerce. Then the service facilities provided by BKK consists of: (1 The job Job Information Center, (2 Blog / Alumni Special Web CMS Oil and Gas, (3 Brochure Jobs, (4 Career Guidance and Job Analysis. While the technique or / methods used in marketing graduates include several aspects, among which are: (1 the management aspect BKK, (2 the management aspect of prospective graduates, (3 the management aspect DU / DI, (4 facet of the management of the partnership. Last is the procedure / stages in the distribution and placement of workers, seen from BKK process consists of three core activities: (1 mapping (the alumni / graduates and DU / DI, (2 the distribution of the alumni / graduates, and (3 a system of alliances with the DU / DI. Based on the above results, it can be concluded that there is a miraculous BKK activities related to the distribution of labor. Some of the jobs include identification process, service facilities in order to provide information on jobs / employment, Engineering / BKK method for marketing graduates, procedures / stages in the distribution and employment are the things that influence the process of planning for the distribution labor.

  15. PENGARUH CORPORATE GOVERNANCE TERHADAP KINERJA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Susy Muchtar

    2016-08-01

    board committees positive effect on the firm performance, board meetings had no influence on the performance of the company, board size has a positive effect on the firm performance, executive directors do not have an influence on the company’s performance as measured by return on assets (ROA and return on equity (ROE, independent non-executive directors have a negative effect on corporate performance as measured by return on assets (ROA, but does not affect the company’s performance as measured by return on equity (ROE. Keywords: Corporate governance, firm performance, board structure, board committee, board meeting, board size, executive directors, independent non executive directors, return on asset, return on equity.

  16. KOMPARASI STRATEGI INVESTASI AKTIF DAN PASIF UNTUK OPTIMALKAN RETURN SAHAM YANG TERDAFTAR DI BURSA EFEK INDNESIA

    Directory of Open Access Journals (Sweden)

    Venus Kusumawardana

    2016-01-01

    Full Text Available The purpose of this study was to test an active strategy (moving leverage with a passive strategy (buy, sell and hold strategy to determine which strategy to generate optimal returns with to compair of all strategy. Method by collecting data is then processed and analyzed using software ChartNexus. An indicators moving everage 5, 10, 30, bollingerband and compare the return of an active strategy with passive strategies. The results of this research note that suitable and appropriate technical analysis to forecast stock prices to determine buy, sell and hold, to optimize stock returns and shows that an active strategy is able to out perform a passive strategy when the market is bearish and volatile. The use of passive strategies can provide superior results, when used on a very bullish market conditions. Volatile market conditions that are more suitable to use the strategy of comparison between the strategies of active and passive strategies.

  17. Analisa Korelasi Return Indeks – Indeks Saham terhadap Indeks Harga Saham Gabungan pada Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Mulyono Mulyono

    2015-08-01

    Full Text Available Stock market generally has the stock price index that measures the performance of stock trading, the Indonesia Stock Exchange has a stock price index that is widely known as Jakarta Composite Index (IHSG. During its development, the Indonesia Stock Exchange has many alternative indexes that measure the performance of stock trading. Research that is to be conducted on the correlation between return of the stock index listed in Indonesia Stock Exchange and return of Jakarta Composite Index. Return stock index listed on the Indonesia Stock Exchange, namely, LQ45 Index, Jakarta Islamic Index (JII, KOMPAS100 Index, BISNIS-27 Index, PEFINDO25 Index and SRI-KEHATI Index, has a close relationship with the return Jakarta Composite,Index which is a reflection of the movement of all existing stock in the market. Return of stocks index that have the highest coefficient correlation is KOMPAS100 In dex, which have return index coefficient correlation is 0.949, thus KOMPAS100 Index that consisting of 100 stocks, based on the results of the study can be used as an alternative investment to get a return that is at least equal or close to the yield given by Jakarta Composite Index(IHSG that consists of 445 stocks

  18. Arthroscopic treatment for synovial chondromatosis of the subacromial bursa associated with partial rotator cuff tear.

    Science.gov (United States)

    Xu, Caiqi; Yang, Xingguang; Zhao, Jinzhong

    2015-02-01

    Synovial chondromatosis is characterized by benign synovial proliferation that leads to chondral or osteochondral foci formation. In this case report, a right-handed female suffered from progressively worsening pain and limited mobility of forward elevation, abduction and external rotation in her right shoulder. A shoulder arthroscopy was conducted, during which, thickened bursal synovium and several loose bodies were observed, associated with bursal side tear of rotator cuff. A thorough synovectomy, subacromial debridement and acromioplasty were conducted. The pathological findings were consistent with synovial chondromatosis. After systematic rehabilitation, the patient had relief of shoulder pain and full range of motions in 14-months follow-up. Case report, Level IV.

  19. Evaluation of the growth of the bursa of fabricius in broilers reared under different light photoperiods

    Science.gov (United States)

    Previous studies have investigated the interaction of different light sources and light intensity. Studies are lacking concerning the effect of different light sources and photoperiods on broiler growth and health. The results reported here are a part of a larger study to evaluate the interaction of...

  20. A review on Black-Scholes model in pricing warrants in Bursa Malaysia

    Science.gov (United States)

    Gunawan, Nur Izzaty Ilmiah Indra; Ibrahim, Siti Nur Iqmal; Rahim, Norhuda Abdul

    2017-01-01

    This paper studies the accuracy of the Black-Scholes (BS) model and the dilution-adjusted Black-Scholes (DABS) model to pricing some warrants traded in the Malaysian market. Mean Absolute Error (MAE) and Mean Absolute Percentage Error (MAPE) are used to compare the two models. Results show that the DABS model is more accurate than the BS model for the selected data.

  1. Using Bursa Folk Songs for Voice Training in Departments of Music Education in Turkey

    Science.gov (United States)

    GüL, Gülnihal; Yildiz, Nedim; Yildiz, Goknur; Necef, Lale; Özer, Nilüfer; Egri, Mehmet

    2016-01-01

    The training of a music teacher's voice, via the examples in his own culture can contribute to getting better results in music education. Therefore, it is believed that transition to Contemporary Turkish Music and then to universal music from our traditional music may be much easier. Accordingly, the use of national resources in voice training is…

  2. Gene expression profiling of innate immune response to Campylobacter jejuni infection in the bursa of broilers

    Science.gov (United States)

    Campylobacter jejuni (C. jejuni) is a commensal microorganism in chickens, but caused significant health problems in humans. Reduction of C. jejuni colonization in the chicken gut will significantly decrease human campylobacteriosis. To study host response to C. jejuni infection in broilers, both ...

  3. KOREKSI BIAS BETA SAHAM DI BURSA EFEK INDONESIA PERIODE 2009-2012

    Directory of Open Access Journals (Sweden)

    Indah Saptorini

    2016-04-01

    Full Text Available This  study  aims  to  determine  whether  the  beta  value  of  shares  listed  on  the Indonesia Stock Exchange (BEI is a bias beta due to nonsynchronous trading activities.  There  are  310  companies  listed  on  the  Stock  Exchange  2009-2012 period  sampled  in  this  study.  The  bias  needs  to  be  corrected.  From  three methods employed : the Scholes and Williams (1977, the Dimson (1979, and the Fowler and Rorke (1983. Results of the analysis conclude that the shares on the Stock Exchange has a bias beta caused by not having a securities trading for  some  time.  This  resulted  in  the  calculation  of  IHSG  the  period  of  t  was biased because it uses the closing price of the period t-1.  In  this  study  bias  beta  correction  method  Scholes  and  Williams  (1977,  both one lag one lead and two lag two lead are better than the bias beta correction method Dimson (1979 and the bias beta correction method Fowler and Rorke (1983 because the value of beta Scholes and Williams after corrected close to one. Keywords : Nonsynchronous tradings, thin tradings, bias

  4. Solitary synovial chondromatosis arising in the gluteus maximus bursa: computed tomography and magnetic resonance imaging findings.

    Science.gov (United States)

    Sumida, Kaoru; Kobayashi, Noriko; Nambu, Atsushi; Tago, Masao; Shibuya, Isao; Kawamoto, Masashi

    2016-03-01

    Chondral tumors in soft tissue are referred to as soft-tissue chondromas or extraskeletal chondromas, or as synovial chondromatosis if they arise in synovial tissue. We report the case of a 29-year-old man with synovial chondromatosis, also called synovial osteochondromatosis, which appeared in a solitary and extra-articular form. On magnetic resonance imaging (MRI) and computed tomography, the central portion of the tumor showed similar characteristics to bone marrow, despite the absence of any connection to adjacent bone. T2-weighted imaging displayed marked peripheral hyperintensity consistent with a cartilaginous area. These findings suggested the presence of enchondral ossification and were similar to those of skeletal osteochondroma, with the exception of the absence of attachment to bone. MRI is useful for distinguishing solitary synovial chondromatosis from other lesions, such as myositis ossificans, extraskeletal chondrosarcoma, and parosteal osteosarcoma.

  5. A Study on Learning Environments of Elementary School Students Taking Social Studies Course: Bursa Sample

    Science.gov (United States)

    Dogan, Yadigar; Sezer, Gonul Onur

    2011-01-01

    Schools as educational and instructional institutions are expected to be renewable ones where motivation is increased through establishing relationships between students' interests and needs, and subject matters of social studies lessons are derived from daily life and events. Finalizing any learning activity at school by realizing it as aimed and…

  6. ASIMETRI INFORMASI DAN PRAKTIK MANAJEMEN LABA PADA PERUSAHAAN MANUFAKTUR DI BURSA EFEK INDONESIA

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    Irma Tyasari

    2009-10-01

    Full Text Available Tujuan dari penelitian ini adalah untuk mendapatkan bukti empiris tentang pengaruh asimetri informasi terhadap praktik manajemen laba, dan untuk mendapatkan bukti empiris tentang pengaruh ukuran perusahaan terhadap praktik manajemen laba. Sampel yang digunakan dalam penelitian ini sebanyak 51 perusahaan manufaktur yang memenuhi kriteria. Metode pengambilan sampel yang digunakan adalah purposive sampling. Setelah dilakukan uji statistik dengan model regresi berganda, maka diperoleh hasil bahwa variabel asimetri informasi berpengaruh terhadap praktik manajemen laba, demikian juga variabel ukuran perusahaan teruji berpengaruh terhadap praktik manajemen laba

  7. PENGUJIAN PECKING ORDER THEORY PADA EMITEN SYARIAH DI BURSA EFEK JAKARTA

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    Sutapa Sutapa

    2017-03-01

    Full Text Available The objective of this study was to test empirically whether capital structure decisionof Indonesian firms followed a hierarchy of sources of finance called Pecking Order. Samplesin this study were 29 firms listed in Jakarta Islamic Index (JII from 2001 to 2004. Variabelsused as proxy of Pecking Order Theory (POT were profitability, investment opportunity andfirm size. The results of this study were as follows: a. simultaneously, all proxies for POT couldexplain capital structure at Indonesian Capital Market, b. more profitable firms were lesslevered, c. bigger firms were more levered, d. result for investment opportunity did notsupport hypothesis. Firms listed at JII tended to follow POT in their financing decision. Part ofresults of this study was consistent with study of Wiwattanakantang (1999, Fama and French(2002, Benito (2003 and Mutamimah (2003.

  8. Simulasi Perdagangan Kontrak Berjangka CPO pada Bursa Malaysia dengan Cyclic Forecasting Periode Januari-Desember 2009

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    Tomy G. Soemapradja

    2011-05-01

    Full Text Available Crude palm oil (CPO is one commodity that could be consumed and also as one alternative of non- fossil fuel: biodiesel. Since 2006, CPO commodity trade has its significant raise, followed by forward contract trade. The increasing of CPO price in 2006 is the lowest in historic analysis data period 2007-2008. Cyclic forecasting model is used following cycle pattern of twice-a-year, with a combination of Solver function in Ms. Excel that could minimize MSE as 161,02, Beta 0,0688 and intercept in -11,0396. Cyclic forecasting period is supposed to be used along with technical analysis, using stop loss to reduce risk. It needs additional research to adjust confidence level so VaR value is not too high that could fix trading strategy along this research. 

  9. Oil Risks and Firm Attributes in Oil Share Prices: Empirical Evidence from Bursa Malaysia

    OpenAIRE

    Safian, Dayana

    2010-01-01

    This research aims to analyze the oil risks and firm attributes that could affect the share prices of oil and gas companies in Malaysia. Most of the studies conducted in regards to the oil and gas sector takes into account the contributing factors such as the condition of oil futures in NYMEX and focuses on prominent oil exporting and importing countries. In contrast, this paper empirically assesses the dynamics of global, national and company level factors that could influence the share p...

  10. Analisis pengaruh penerapan prinsip good corporate governance terhadap kinerja perusahaan di Bursa Efek Indonesia

    OpenAIRE

    Sinaga, Yohanna Pricillya

    2015-01-01

    The data used is secondary data. This study uses the data of financial statements by 26 (twenty-six) Company in Indonesia Stock Exchange during 2011-2013. Data collection method using the study documentation and data analysis method used is multiple linearanalysis using the F test (simultaneous) and T test (Test partially) with significance level (α) = 5%. The results showed that the variables Independent Commissioner Board, Board of Directors, Audit Committee, Institutional...

  11. Penggunaan Hedging oleh Perusahaan Telekomunikasi yang Tercatat Pada Bursa Efek Indonesia

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    Basyid Ahmad

    2017-09-01

    Full Text Available The aims of this research were to have a comprehensive understanding on hedging implementation in telecommunication companies and to comprehend the impact of hedge to firm value of the companies. In this research, hedging is the moderating variable between independent variable and dependent variable. The independent variables included profit, firm size, leverage, growth, dividend and liquidity while the dependent variable included firm value. The method used was the ordinary least Square. The samples were taken from 2 telecommunication companies, and the data observed included the quarterly financial data from 2006 to 2015. The findings showed that derivative transactions used as hedge by the companies included cross currency swap, forward and option. Furthermore, the use of hedging foreign exchange was not seen to affect the firm value for the telecommunication company. This is because the 5 moderating variables did not significantly affect the firm value and only 1 moderating variable had a significantly negative effect on the firm value. Keywords: derivative, foreign exchange, firm value, hedge, telecommunication’ companyAbstrak: Tujuan dari penelitian ini adalah untuk menggambarkan penerapan hedging pada perusahaan telekomunikasi publik serta mengetahui dampak hedging terhadap nilai perusahaan. Dalam penelitian ini, hedging merupakan variabel moderating terhadap berbagai variabel yang memengaruhi nilai perusahaan yaitu variabel profitabilitas, firm size, leverage, growth, dividen dan likuiditas. Teknik analisis yang dipakai, yaitu regresi (ordinary least Square. Sedangkan perusahaan yang diteliti sebanyak 2 perusahaan publik dengan data keuangan triwulan sejak tahun 2006 sampai dengan 2015. Hasil penelitian menunjukkan bahwa hedging dilakukan perusahaan telekomunikasi adalah melalui transaksi derivatif, yaitu cross currency swap, forward dan option. Secara umum hedging tidak memengaruhi nilai perusahaan mengingat 5 variabel yang telah dimoderasi tidak berpengaruh signifikan dan hanya 1 variabel yang telah dimoderasi yaitu profitabilitas berpengaruh signifikan negatif terhadap nilai perusahaan.Kata kunci: transaksi derivatif, mata uang asing, nilai perusahaan, lindung nilai, perusahaan telekomunikasi

  12. Kinerja Keuangan dan Tingkat Pengembalian Saham: Studi pada Perusahaan Asuransi di Bursa Efek Indonesia

    OpenAIRE

    Rahmawati, Amalia

    2017-01-01

    Financial Performance and Stock Return: Study at Insurance Companies Listed in The Indonesian Stock ExchangeMuch of the literature said that financial performance had an effect on the stock return, including in insurance company. The purpose of this research is to examine the effect of financial performance to stock return of insurance company that listed in Indonesia stock exchange. This research is using multiple regressions as analysis technique. The results showed that all the variables s...

  13. Kinerja Keuangan dan Tingkat Pengembalian Saham: Studi Pada Perusahaan Asuransi di Bursa Efek Indonesia

    OpenAIRE

    Amalia Rahmawati

    2017-01-01

    Financial Performance and Stock Return: Study at Insurance Companies Listed in The Indonesian Stock ExchangeMuch of the literature said that financial performance had an effect on the stock return, including in insurance company. The purpose of this research is to examine the effect of financial performance to stock return of insurance company that listed in Indonesia stock exchange. This research is using multiple regressions as analysis technique. The results showed that all the variables s...

  14. PERAN INDIKATOR KEKAYAAN INTELEKTUAL TERHADAP KINERJA PERUSAHAAN PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA

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    Elen Puspitasari

    2015-04-01

    Full Text Available Capability of knowledge and technology becomes a key factor for the progress of the economy in many developed countries, so there is a necessity intended for companies to change their business strategy, which was originally based labor force towards knowledge-based businesses. Companies need to communicate some other information to users of financial statements related to the value added that is owned by the company i.e. intellectual capital (IC.This study will describe the role of IC indicators as measured by VAICTM, which consists of VACA, VAHU, and STVA to the company's performance measured by market valuation, profitability and productivity,which firm size as a control variable. The population in this study is manufacturing companies listed on the IDX from 2007 to 2010, with purposive sampling to obtain a sample of 20 companies with 80 data observations. The results of statistical hypothesis testing using multiple linear regression test showed that the IC has a positive and significant influence on company's performance. Kemampuan pengetahuan dan teknologi menjadi faktor kunci bagi kemajuan ekonomi di banyak negara maju, sehingga ada kebutuhan yang ditujukan bagi perusahaan untuk mengubah strategi bisnis mereka, yang pada awalnya berbasis tenaga kerja terhadap usaha berbasis pengetahuan. Perusahaan perlu berkomunikasi beberapa informasi lain untuk pengguna laporan keuangan yang berkaitan dengan nilai tambah yang dimiliki oleh perusahaan yaitu modal intelektual (IC. Penelitian ini akan menjelaskan peran IC indikator yang diukur dengan VAIC, yang terdiri dari VACA, VAHU, dan STVA untuk kinerja perusahaan yang diukur dengan nilai pasar, profitabilitas dan produktivitas, yang ukuran perusahaan sebagai variabel kontrol. Populasi dalam penelitian ini adalah perusahaan manufaktur yang terdaftar di BEI 2007-2010, dengan purposive sampling untuk mendapatkan sampel dari 20 perusahaan dengan 80 data pengamatan. Hasil pengujian hipotesis statistik menggunakan uji regresi linier berganda menunjukkan bahwa IC berpengaruh positif dan signifikan terhadap kinerja perusahaan.

  15. Merger Auditor dan Kualitas Audit: Bukti Empiris Dari Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Sansaloni Butar-Butar

    2016-06-01

    Full Text Available Merge rof Pricewaterhouse and Coopers & Lybrands that occurred in 1998 creates PricewaterhouseCoopers as the biggest accounting firm in history. Conceptually and supported by previous empirical result firm size is expected to be positively correlated with audit quality. Large accounting firms have financial ability to improve its auditors skill and can act more independently because major part of their income do not come from one or two clients. They spend huge investment in audit technology as well. However, this positive relationship only applies to environments where punishment is strictly imposed on audit failure. Unlike their counterparts in the United States and Europe, auditors working in Indonesia rarely face legal issues related to the audit assignment. In addition, empirical studies in Indonesia have always classified local auditors as Big N auditors if they affiliate with one of Big N auditors assuming same quality with that of Big N auditors. This assumption does not necessarily hold. Therefore, in the context of Indonesia environtments, this study predicts PricewaterhouseCoopers merger does not affect the quality of the audit. Using abnormal accruals as a proxy for audit quality, the results show that after the merger audit quality has declined significantly.

  16. Subdeltoid Bursa Tuberculosis with Rice Body Formation–A Case Report

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    Santosh L. Munde

    2015-01-01

    Full Text Available Tuberculous tenosynovitis and bursitis account for approximately 1%. A 56 years old female presented with swelling in left shoulder, gradually increasing in size with slight restriction in movement since last three months. X-ray revealed no abnormality of humerus head. Histopathological examination showed granulomatous tissue with multiple rice bodies. A positive culture of mycobacterium tuberculosis confirmed the diagnosis of tuberculosis. We here report a case of subdeltoid bursitis with rice body formation and without active bone and joint tuberculosis.

  17. Determinan Intensitas Transaksi Afiliasi pada Perusahaan-perusahaan dalam Grup Bisnis di Bursa Efek Indonesia

    OpenAIRE

    Martua Eliakim Tambunan; Hermanto Siregar; Adler Haymans Manurung; Dominicus Savio Priyarsono

    2016-01-01

    Abstract. Related party transactions are important corporate actions with the highest incidence rate of all issuers’ corporate actions listed in the Indonesia Stock Exchange. Related party transactions' intensity allows minority holders' expropriation right and affects company's value. This study aimed to analyze the determinants affecting related party transactions’ intensity in companies in the business groups in the Indonesia Stock Exchange. The determinants were ultimate shareholders, go...

  18. Kinerja Keuangan dan Tingkat Pengembalian Saham: Studi Pada Perusahaan Asuransi di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Amalia Rahmawati

    2017-02-01

    Full Text Available Financial Performance and Stock Return: Study at Insurance Companies Listed in The Indonesian Stock ExchangeMuch of the literature said that financial performance had an effect on the stock return, including in insurance company. The purpose of this research is to examine the effect of financial performance to stock return of insurance company that listed in Indonesia stock exchange. This research is using multiple regressions as analysis technique. The results showed that all the variables simultaneously had an effect on the stock return. By partially showed that Price Book Value, Incurred Loss Ratio, Premium Growth Ratio, and Total Asset Turnover has no significant influence on the stock return. While Return on Equity has significant positive influence on the stock return and Debt on Asset Ratio, Net Profit Margin has significant negative influence on the stock return.DOI: 10.15408/ess.v7i1.4724

  19. Analisis Hubungan Profitabilitas dengan Harga Saham Sektor Usaha Makanan dan Minuman di Bursa Efek Jakarta

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    Ignatius Sarto Kothson Budiman

    2007-03-01

    Full Text Available Stock price movement was influenced by many factors, such as company performance, interest level, political factors, security, etc. Article purposes to get approximate probability on the influence between company profitability level and stock price movement that was traded on the Jakarta Stock Exchange, it also considered external factor influence on the stock price movement. The profitability ratio was represented by Net Profit Margin (NPM, Return On Investment (ROI, and Return On Equity (ROE. The research result indicated that the profitability ratio, such as Net Profit Margin (NPM and Return On Investment (ROI have significant influence the stock price movement while Return On Equity (ROE did not have significant influence on the stock price movement.

  20. Profitabilitas Strategi Momentum di Bursa Efek Indonesia (Periode Januari 2003 – Desember 2007

    Directory of Open Access Journals (Sweden)

    B Yuliarto Nugroho

    2008-12-01

    Full Text Available Momentum trading strategy present challenges to the concept of efficient market theory. Many studies investigate the profitability of momentum trading strategy in international and domestic equity market and evidence has shown that this strategy could lead to abnormal profit. The purpose of this paper are to examine and analyse the profitability of momentum strategy in the Indonesia equity market from January 2003 to December 2007. This paper also investigates factor such as size and trading volume to identify potential source of profits in momentum strategy. The result of this research show that short-term momentum strategy are profitable on all stock listed on IDX. The findings of the research also show that in the shortterm, trading volume have significant effects and could be potential source of profits in momentum strategy.Keywords: profitability, momentum, size, trading volume

  1. Determinan Intensitas Transaksi Afiliasi pada Perusahaan-perusahaan dalam Grup Bisnis di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Martua Eliakim Tambunan

    2016-08-01

    Full Text Available Abstract. Related party transactions are important corporate actions with the highest incidence rate of all issuers’ corporate actions listed in the Indonesia Stock Exchange. Related party transactions' intensity allows minority holders' expropriation right and affects company's value. This study aimed to analyze the determinants affecting related party transactions’ intensity in companies in the business groups in the Indonesia Stock Exchange. The determinants were ultimate shareholders, good corporate governance (with independent commissioner and the Big Four public accounting firms as proxies, debt to equity ratio, and period of crisis. This study used panel data with quarterly time period from 2006 to 2013. Samples were determined by purposive sampling focusing on companies’ typology, namely companies in the three business groups representing the market capitalization’s three layers. The results showed that ultimate shareholders insignificantly had positive effect on related party transactions’ intensity. Independent commisioners and debt to equity ratio significantly had positive effect on related party transactions’ intensity. The Big Four public accounting firms significantly had negative effect on related party transactions’ intensity. Period of crisis insignificantly had negative effect on related party transactions’ intensity. The determinants as a whole have an effect on the intensity of related party transactions. Keywords: related party transaction, business group, ultimate shareholder, good corporate governance, debt to equity ratio

  2. ANALISIS PENENTUAN MODEL MERGER-AKUISISI YANG SINERGIS DI BURSA EFEK INDONESIA

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    Muhamad Umar Mai

    2016-10-01

    Full Text Available The aim of this study was as follow: a to examine the differences in financial performance and the value of the firm before and after the merger-acquisition of go public company in Indonesia Stock Exchange for the period of 2000-2012;b to identify and analyze the critical success factors of mergers-acquisitions; c designing a model of synergistic merger-acquisition. Wilcoxon signed ranks test results showed that the financial performance and the value of the company for certain years are different, in the sense of increased, significantly. The determinant factors of successfull merger-acquisition of 30 synergistic firms, are: a current ratio and cash ratio was below the industry average; b debt to asset ratio and debt to equity ratio is above the industry average; c return on investment and return on equity also above the industry average. Analysis of the 30 synergisticbidders firm shows that the company has a very adequate corporate governance mechanism, namely: a more than 50% of its stocks owned by other institutions; b the shares held by the management is below 5%; c the membership of the board of commissioners and directors have an independent boards and outside directors of more than 30%; and d the average number of commissioners as many as six people.

  3. A cholesterol-containing foreign body granuloma presenting as an inter-metatarsal bursa

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, R.S.D. [Royal Liverpool University Hospital, Department of Radiology, Liverpool (United Kingdom); Montgomery, R.J. [James Cook University Hospital, Department of Trauma and Orthopaedics, Middlesbrough (United Kingdom)

    2005-04-01

    A 68-year-old man presented with progressive forefoot swelling which coincided with the onset of type 2 diabetes mellitus. Imaging revealed a cystic inter-metatarsal mass containing two foreign bodies, which had been present for many years. Following aspiration of the mass, cholesterol crystals were observed on polarised microscopy. It is postulated that the development of diabetes triggered the shedding of cholesterol crystals around a long-standing quiescent foreign body granuloma. (orig.)

  4. PENGARUH LIKUIDITAS MODAL KERJA TERHADAP PROFITABILITAS PERUSAHAAN SEKTOR PERUNGGASAN YANG TERDAFTAR DI BURSA EFEK INDONESIA

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    Cosmas A.I. Wardojo

    2016-11-01

    Full Text Available Working capital management is one of the most frequently discussed topics in researches, for companies attempt to obtain liquidity and operational efficiency in managing their working capital. Hence, this study aimed to analyze the company profitability and capital policy influences performed by the poultry sector company towards company profitability in the same period. The method in the study was a panel regression by adopting Ordinary Least Square estimation method and by using fixed effects in reference to Chow test results. Classic assumption test and Goodness of Fit Tests were also conducted to examine the selected models. The results showed that the components of cash conversion cycle and net trade cycle have significant positive effects on profitability, enabling the industry to increase profits by effectively managing each part of net working capital.Keywords: cash conversion cycle, net working capital, net trade cycle, profitability, working capital management, ordinary least squareABSTRAKManajemen modal kerja merupakan topik yang paling sering didiskusikan dalam penelitian, perusahaan berusaha mendapatkan likuiditas dan efisiensi operasional dalam mengelola modal kerja mereka. Penelitian ini bertujuan menganalisis profitabilitas perusahaan dan  pengaruh kebijakan modal kerja yang dilakukan oleh perusahaan disektor perunggasan terhadap profitabilitas perusahaan dalam kurun waktu yang sama. Metode  yang digunakan adalah regresi panel dengan metode pendugaan Ordinary Least Square menggunakan efek tetap berdasarkan hasil uji Chow. Uji asumsi klasik dan Goodness of Fit Uji juga telah dilakukan untuk menguji model yang terpilih. Hasil penelitian menunjukkan bahwa konversi kas komponen siklus dan siklus perdagangan bersih berpengaruh positif signifikan terhadap profitabilitas, sehingga industri dapat meningkatkan keuntungan dengan mengelola secara efektif setiap bagian dari modal kerja bersih.Kata kunci: siklus konversi kas, modal kerja bersih, net trade cycle, profitabilitas, pengelolaan modal kerja, ordinary least square.

  5. PENGARUH BULAN RAMADHAN TERHADAP RETURN PASAR SAHAM DI BURSA EFEK INDONESIA (1425H-1434H

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    Aprida Rusmayanti

    2016-06-01

    Full Text Available The phenomenon of monthly effect is when the desire of financiers on the liquidity of stock changes from month to month in a year. This monthly effect of course is contrary to the concept of efficient markets, but it gives confidence to investors that there is still a gap to benefit by using information of price and sales volume in past. Ramadhan effect is monthly effect, it has been investigated several time in Islamic countries and it was found that there was a difference in market return during Ramadhan month rather than during any other months. The purpose of this study was to describe the effect of Ramadhan on the stock market return in the Indonesia Stock Exchange (IDX. Ramadhan effect, is a seasonal anomaly in the financial markets, when stock returns during Ramadhan is different from the other. The unit of analysis used in this study is a JSX composite of 1425H-1434H (February 21, 2004 -3 November 2013. The statistical method used to test the hypothesis is nonparametric test (sign test, because the data are not normally distributed. The results showed that there was no influence of Ramadhan on the stock market return in the Indonesia Stock Exchange.  The cause of the lack of differences in returns among others due to the stability of the value of JSX Composite which is basic calculation of returns, but it also may be due to cultural differences and different conditions during the month of Ramadhan between Indonesia and other countries. Investor behavior changes that occur in other countries during Ramadhan does not occur in Indonesia due to the investors’s composition in Indonesia is still dominated by foreign and institutional investors. The results of this study indicate that the capital market in Indonesia efficient in weak form, because the pattern of stock price movement is random or unpredictable  Keywords:Return of stock market, Ramadhan

  6. Determinan Harga saham Perbankan yang Terdaftar (2009-2012 di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Panji Rizki Maulana

    2015-08-01

    Full Text Available This study aims to analyze the influence of internal and external factors in the Indonesian banking on stock price on 2009-2012. The data analysis was using multiple linear regression analysis for 27 banks in Indonesia. The results showed that the bank’s internal factors, which are Capital, Asset Quality, Management, Earnings, Liquidity effect the banking stocks price, while Sensitivity to Market Risk has no effect on stock price. The external factors of bank, GDP and Interest Rate have a significant effect on stock price, while the Exchange Rate has no influence on the stock price.

  7. Faktor-Faktor yang Mempengaruhi Earnings Response Coeficient pada Perusahaan yang Terdaftar di Bursa Efek Jakarta

    OpenAIRE

    Mulyani, Sri; Asyik, Nur Fadjrih; Andayani, Andayani

    2007-01-01

    The objective of this study is to examine factors affect earnings response coefficient consist of earnings persistence, capital structure, systematic risk (beta), earnings growth, and firm size (Scott, 2000). The study added one variable, that is audit quality. Teoh and Wong (1993) argue that audit quality is positively associated with client's quality of earnings and the earnings response coefficient.Samples used in this study are 255 firms listed in the Jakarta Stock Exchange (JSE) from 200...

  8. Spesialisasi Industri Auditor Sebagai Prediktor Earnings Response Coefficient Perusahaan Publik yang Terdaftar di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Hans Hananto Andreas

    2012-01-01

    Full Text Available This study investigates the effect of auditor’s industry specialisation on the ERC of public companies listed on the BEI in the period of 2006-2010. The purpose of this study is to examine the relationship between audit quality as proxied by auditor’s industry specialisation and the earnings information quality as measured by ERC. Hypothesis testing was conducted using multiple linear regression technique. Using purposive sampling technique, 134 public companies listed on the BEI were selected as the sample of this study. This study finds that there is a positive relationship between auditor’s industry specialisation and company’s ERC. The ERC of companies that use auditors with industry specialisation is higher than ERC of companies that do not use auditors with industry specialisation.

  9. FAKTOR PENENTU RETURN SAHAM DENGAN PRICE TO BOOK VALUE SEBAGAI VARIABEL MODERASI DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Sri Lestari Kurniawati

    2017-03-01

    Full Text Available The purpose of this study was to exemine the effect of the company’s financial performance variables consistingof earning growth ratio, dividend payout ratio and size, the variable return equity price to book value as amoderating variable. The samples in this study were all companies listed on the Indonesia Stock Exchangefrom 2005 to 2010 by using purposive sampling with criteria that the company had a positive book value ofequity during the study period. The company splitted the cash dividend and the company did not do corporateactions such as stock splits, reverse stock, stock dividend. The data used in this study were all companies listedon the Indonesia Stock Exchange from 2005 to 2010 (except for companies engaged in finance and banking byusing multiple linear regression to test the interaction or Multiple Regresion Analysis (MRA. The studyfound that the price to book value was not able to significantly moderate the effect of earning growth ratio,dividend payout ratio and size toward the stock return variable for the interaction test results showed thesignificant value was greater than interaction of alpha as 5%.

  10. FAKTOR-FAKTOR YANG MEMENGARUHI KEBIJAKAN UTANG PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Christine Dwi Karya Susilawati

    2017-03-01

    Full Text Available In the last several years, there had been an increase on the research emphasized on the agent-principal conceptat financial corporation. The objective of this research was to test empirically the agency concept and theirrelation toward the debt policy of corporations. This research analyzed the factors influencing debt policy atmanufacturing firms in Indonesia. Analyzing instruments in this research was multiple regression analysis.The result of this research showed that firm size, profitability and free cash flow had significant influence todebt policy while managerial ownership, institutional ownership, dividend policy and structure asset did nothave significant influence to debt policy. However, simultaneously the seven variables had significant influenceto debt policy.

  11. ANALISIS DEBT FINANCING PADA PERUSAHAAN INTERNASIONAL DAN PERUSAHAAN DOMESTIK YANG TERDAFTAR DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Nilmawati Nilmawati

    2017-03-01

    Full Text Available The purpose of the research was to analyze and find empirical evidence of theeffect of categories of companies (international and domestic on the level of debt using in thelisted companies in Indonesian Stock Exchange by controlling variables such as: risk, profitability,size, tangible fixed asset, growth, and agency problem. Multiple linier regression and chowtest were used for instrument analysis. The results showed that firm category did not effect thelevel of debt using, and there were only 2 control variables (profitability and agency affectingthe level of debt using.

  12. Pengaruh Dividend Initiations dan Dividend Cut/Omissions terhadap Return Saham di Bursa Efek Jakarta

    Directory of Open Access Journals (Sweden)

    Sri Dwi Ari Ambarwati

    2009-08-01

    Full Text Available This research investigates market reactions to initiations and cut/omissions of cash dividend payment. Consistent with prior literature, the result of this research tend to support the propositions that shareholders make considerable use of the information implicit in dividend announcement. Shareholders react positively significant to the dividend initiations announcement and negatively significant to the dividend cut/omissions announcement. A multiple regression model is formulated to identify the factors that contribute significantly to the capital gain (loss suffered by shareholders when firm decide to initiate (cut/omit dividend. Result indicate that, in conformity with the information content hypothesis, the shareholders’s respond to dividend initiations significantly depends on  the firm size and the cumulative return movement (CARM in the preceding period. Whereas, the shareholders’s re¬spond to dividend cut/omissions significantly depends on the cumulative return movement (CARM in the preced¬ing period and risk/corrected beta of the firm at alpha 1% and 5%.Keywords: Signaling hypothesis, Dividend initiations, dividend cut/omissions

  13. Mineral and whole-rock geochemistry of the Topuk Granitoid (Bursa, Western Anatolia, Turkey)

    Science.gov (United States)

    Orhan, Ayşe; Demirbilek, Mehmet; Mutlu, Halim

    2014-05-01

    The Eocene aged Topuk Granitoid exposing in the Tavşanlı Zone at south of the Izmir-Ankara Suture Zone is one of the granitoids which were formed as a result of collision of the Anatolide-Tauride block with the Sakarya continent in the late Cretaceous. Nearly east-west extending, elliptical shaped Topuk Granitoid was intruded into the Paleozoic and Mesozoic metamorphites and upper Cretaceous ophiolitic rocks. The intrusion is in granodiorite composition and contains spherical/ellipsoidal mafic microgranular enclaves (MME) with composition of monzodiorite to monzogabbro. The granitoid which contains xenoliths is frequently cut by porphyritic granodiorite, granite aplite and quartz dikes at the margins. Topuk Granitoid is represented by an I-type pluton with medium to high K calc-alkaline affinity and metaluminous melt composition. Ocean ridge granite (ORG) normalized element distributions show that the granitoid, dikes and MME's have similar patterns. A significant enrichment of LIL (Rb, Ba, K, Th and Sr) elements and relatively depletion of HFS (Ta, Nb, Ce, Hf, Y, Zr and Ti) elements are indicative of formation from hybrid magma in a subduction environment. In tectonic discrimination diagrams (Ta -Yb and Rb-Y+Nb), samples of the Topuk Granitoid are plotted into the volcanic arc granite (VAG) field which is characteristic for the post collision granites. The results of mineral chemistry show that plagioclases are in oligoclase-andesine (An20-49) composition, amphiboles are of magnesio-hornblende and biotites are of Fe-Mg-biotite composition. In the Al2O3-FeO-MgO diagram biotite minerals are accompanied by amphibole and other ferromagnesian minerals and represent biotites of calc-alkaline orogenic zones. Calculations based on the hornblende-barometer indicate that the calc-alkaline magma was crystallized under pressure of 2-6 kbars (mean=4 kbars) and at depth of 7-20 km (mean=12 km). The whole-rock and mineral chemistry data show that the Topuk Granitoid was formed by the interaction of post-collisional, calc-alkaline, metaluminous and I-type coeval felsic and mafic magmas at shallow depths under similar physicochemical conditions. Keywords: Turkey, Western Anatolia, Topuk Granitoid, geochemistry. Acknowledgement: This study is supported by the Scientific and Technical Research Council of Turkey (TÜBİTAK; YDABAG-111Y289).

  14. Pengaruh Perputaran Total Aktiva dan Leverage terhadap Kinerja Keuangan Perusahaan Barang Konsumsi di Bursa Efek Indonesia

    OpenAIRE

    Lumbantobing, Elgina Bungaria

    2015-01-01

    The purposeof this studyis to knowandanalyze theeffect ofTotal Asset Turnoverand Leverage (Debt to Asset) to Financial Performance (ROA) consumer goods companies listed on the Indonesian Stock Exchange. The data used in this study is secondary data. Secondary data obtained from the annual financial statements of listed consumer goods companies on the Stock Exchange during the period 2008-2012 from the Indonesian Stock Exchange website and the Indonesian Capital Market Directory (ICMD), j...

  15. PENGUJIAN GARCH OPTION MODEL UNTUK BARRIER OPTION DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Tendi Haruman

    2017-03-01

    Full Text Available The purpose of this research was to test the accuracy of GARCH Option Model forpricing stock option contracted on Astra International, BCA, Indofood and Telkom when barrierexisted at The Indonesia Stock Exchange. Utilizing intraday stock movement and stock optioncontract data, simulation was conducted using actual data. To test the accuracy of GARCH OptionModel, average percentage mean squared error was used to compare simulated premiumwith its payoff at its maturity date. The findings from this research were one month optionaverage percentage mean squared error of GARCH Option Model was three point fifty onepercent (3.51%, two month option was six point sixty one (6.61% and three month optionwas seven point seventy nine percent (7.79%.

  16. Pengaruh Financial Leverage terhadap Profitabilitas Pada Perusahaan Perkebunan dan Pertambangan yang terdaftar di Bursa Efek Indonesia

    OpenAIRE

    Islamia, Putri

    2013-01-01

    The purpose of this research is to know the influence of financial leverage consists of debt to total asset ratio (DAR), debt to equity ratio (DER), and long term debt to total asset ratio (LDAR) either partially or simultaneously toward profitability that is return on equity in plantations and minning firms on Indonesia Stocks Exchange. This research is classified as causal research with 18 plantations and minning firms listed in Indonesia Stocks Exchange during 2008 to 2010. The...

  17. Pengaruh Dividend Yield dan Earning Volatility terhadap Volativitas Harga Saham di Bursa Efek Jakarta

    Directory of Open Access Journals (Sweden)

    Rani Ramdhani

    2012-05-01

    Full Text Available Some investors prefer dividend yield than capital gain. Information signal follows to dividend policy that describes the earnings volatility in the future, which affects the stock price volatility on the Jakarta Stock Exchange.

  18. Pengaruh Dividend Yield dan Earning Volatility terhadap Volativitas Harga Saham di Bursa Efek Jakarta

    Directory of Open Access Journals (Sweden)

    Rani Ramdhani

    2012-11-01

    Full Text Available Some investors prefer dividend yield than capital gain, information signal follows to dividend policy that describes the earnings volatility in the future, which affects the stock price volatility on the Jakarta Stock Exchange.

  19. Pengaruh Dividend Yield dan Earning Volatility terhadap Volativitas Harga Saham di Bursa Efek Jakarta

    OpenAIRE

    Rani Ramdhani

    2012-01-01

    Some investors prefer dividend yield than capital gain. Information signal follows to dividend policy that describes the earnings volatility in the future, which affects the stock price volatility on the Jakarta Stock Exchange.

  20. Pengaruh Rasio CAMEL Terhadap Kinerja Keuangan Perbankan yang Terdaftar di Bursa Efek Indonesia (BEI)

    OpenAIRE

    Lestari, Tika

    2010-01-01

    This research aims to determine the influence of CAMEL ratios to the Financial Performance of banks listed on the Indonesia Stock Exchange. CAMEL ratios used in this study is the Capital Adequacy Ratio (CAR), Non-Performing Loan (NPL), Return On Assets (ROA), Return On Equity (ROE), Net Interest Margin (NIM), Operating Expenses (ROA), Loan to Deposit ratio (LDR) and Financial Performance is measured by Net Income Growth. This research is a kind of causal research, which examines the effect of...

  1. PENDEKATAN MODEL PENILAIAN DALAM PENGAMBILAN KEPUTUSAN INVESTASI SAHAM DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Sri Isworo Ediningsih

    2017-03-01

    Full Text Available A valuation model was a mechanism that converted a set of forecast, a series of company and economic variablesinto a forecast of market value for the company’s stock. The purpose of this study was to examine relevance amongdividend yield, retained earnings, book value and total debt on stock price: approximation valuation model in theIndonesia Stock Exchange. Samples in this study were manufacture firms listed on the Indonesia Stock Exchangeperiod 2008–2011 and divided dividend. The results showed that few of samples were undervalue and the otherswere overvalue. It meant valuation model could be applicated in the Indonesian stock exchange. By using multipleregressions, this study found that: valuation model relevans used in investment decission in manufacturefirms in the Indonesia Stock Exchange could prove simultaneously dividend yield, retained earnings, book valueand total debt had significant effect to stock price and partially dividend yield had no significant effect to stockprice and whereas retained earnings, book value and total debt had significant effect in partial to stock price.

  2. Kinerja Portofolio Saham pada Perusahaan Makanan, Property dan Pertambangan di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Nasri Zarman

    2017-06-01

    Full Text Available The Stock Portfolios' Performance of Food, Property, and Mining IndustryThis research aimed to analyze the Portfolio's performance of food industry, property, and mining. There are three parameters, namely: Sharpe Performance, Traynor Performance, and Jensen Performance. The three performance measurements assume that there is a linear connection between the return portfolios with the return of some market index. During the period, 2009 to 2013, and the mining and gas sub-sector are more productive than the other sub-sectors. The mining sector is better than the Property Sector and the Food Sector. Then based on the method of Jensen ALPHA it showed the highest performance group of mining stocks, in proportion to the risk which is also very high. The study suggests that the existing has to be maintained and further improved so that the mission to develop sources of potential energy into a profitable investment portfolio can sustain.DOI: 10.15408/ess.v7i2.5354

  3. 75 FR 35291 - Foreign Futures and Options Transactions

    Science.gov (United States)

    2010-06-22

    ... an exemption to firms designated by Bursa Malaysia Derivatives Berhad (Bursa Derivatives), a subsidiary of Bursa Malaysia Berhad (Bursa Malaysia), from the application of certain of the Commission's... Exempting Firms Designated by Bursa Malaysia Derivatives (Bursa Derivatives) From the Application of Certain...

  4. Synthesis and Characterization of PEGylated Toll Like Receptor 7 Ligands

    OpenAIRE

    Chan, Michael; Hayashi, Tomoko; Mathewson, Richard D.; Yao, Shiyin; Gray, Christine; Tawatao, Rommel; Kalenian, Kevin; Zhang, Yanmei; Hayashi, Yuki; Lao, Fitzgerald S.; Cottam, Howard B.; Carson, Dennis A.

    2011-01-01

    Toll like receptor 7 (TLR7) is located in the endosomal compartment of immune cells. Signaling through TLR7, mediated by the adaptor protein MyD88, stimulates the innate immune system and shapes adaptive immune responses. Previously, we characterized TLR7 ligands conjugated to protein, lipid or polyethylene glycol (PEG). Among the TLR7 ligand conjugates, the addition of PEG chains reduced the agonistic potency. PEGs are safe in humans and widely used for improvement of pharmacokinetics in exi...

  5. Pengaruh Pengungkapan Corporate Social Responsibility Terhadap Kinerja Keuangan Dan Nilai Perusahaan (Studi Komparatif Pada Perusahaan Multinasional Yang Terdaftar Di Bursa Efek Indonesia Dan Bursa Malaysia Tahun 2012-2015)

    OpenAIRE

    Sari, Wahyu Aprilia; Handayani, Siti Ragil; Nuzula, Nila Firdausi

    2016-01-01

    The main objective of this research was to investigate the impact of CSR Disclosure (CSRD) on firm's financial performance and firm's value, also to compare the level of CSRD between Multinational Companies (MNCs) in Indonesia and Malaysia. Independent variabel used is CSRD, dependent variabels used are Return On Assets (ROA) to measure firm's financial performace, and Tobin's Q to measure firm's value. Applying quantitaive and explanatory research, and using 9 MNCs selected from Indonesia St...

  6. RESPON MAHASISWA PERBANKAN SYARI’AH TERHADAP PENDIRIAN GALERI INVESTASI BURSA EFEK INDONESIA SEKOLAH TINGGI AGAMA ISLAM NEGERI PAMEKASAN

    Directory of Open Access Journals (Sweden)

    Lely Shofa Imama

    2015-12-01

    Full Text Available BEI Investment gallery STAIN Pamekasan as a realization of capital market laboratory will always engage academician, especially Perbankan Syari’ah students, as the object of the investment gallery. This research is field research employing descriptive quantitative method. Its objective is to identify the level of knowledge and response toward the existence of BEI Investment gallery in STAIN Pamekasan. The result shows that students of Syariah Banking Program just simply know, whereas they absolutely agree with the urgency of laboratory capital market and the founding of BEI investment gallery STAIN Pamekasan.

  7. Analisis Faktor-Faktor yang Mempengaruhi Peringkat Obligasi Pada Perusahaan Perbankan yang Terdaftar di Bursa Efek Indonesia

    OpenAIRE

    Damanik, Imam Rohtuah

    2015-01-01

    The objective of this research is to determine the factors impact to the bonds rating of banking companies listed on the Indonesia Stock Exchange. The sample in this research is 9 banking companies listed on the Indonesia Stock Exchange from 2010-2013 with maturity bond variable as moderating variable to moderate relationship between leverage variable and bonds rating. Research methods in this research using purposive sampling. The type of data used are secondary data. Data that used in th...

  8. DAMPAK RISIKO DEFAULT BANK TERHADAP RISIKO SISTEMIK PERBANKAN DAN RISIKO SISTEMATIK BURSA SAHAM DI LIMA NEGARA ASEAN

    Directory of Open Access Journals (Sweden)

    Buddi Wibowo

    2016-05-01

    Full Text Available Abstract Global financial crisis in 2008 has driven special attention to systemic banking sector risk that cause byindividual bank default. Though, banking crisis significantly affect economic growth and national macroeco-nomic condition. Individual bank default non only affect banking industry but also has serious injured theeconomy. Bank default risk not only affect systemic risk but also systematic risk.ASEAN financial integrationplan raise a need to understand characteristics of ASEAN banking industry. Close relationship and intercon-nection between ASEAN economies will make individual bank default a serious issue that its effect will spreadto all ASEAN economy. This research aimed to investigate the effect of bank default risk on systemic andsystematic risk in 5 ASEAN countries. We find that bank default risk significantlyraised systemic risk, esspeciallyin country with high concentration in its banking industry structure. Big banks tend to more serious effect onsystemic risk. Systematic risk tend to be affected by macroeconomy condition, rather than default risk ofindividual bank.

  9. Pengaruh Mekanisme Corporate Governance Terhadap Pelaksanaan Enterprise Risk Manegement pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia

    OpenAIRE

    Sitinjak, Mauritz P I

    2016-01-01

    This study aimed to examine the effect of corporate governance mechanism on the implementation of enterprise risk management. Variable corporate governance mechanism in this study consisted of, independent board, board size and audit committee size. The population in this research is manufacturing companies that listed in Indonesia Stock Exchange 2013-2014 period. Sample selection is done by purposive sampling method so that samples obtained for this study amounted to 89 companies. Data an...

  10. PENGARUH MODAL INTELEKTUAL PADA KINERJA PASAR PERUSAHAAN (Studi Empiris pada Perusahaan Keuangan yang Terdaftar di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    NI WAYAN YUNIASIH

    2011-07-01

    Full Text Available Intellectual capital is believed to be a contributing factor to companies’ performances and values. Several studies have been carried out on the influence of this capital to a company’s performance. However, the results still show some inconsistencies. Therefore, this study aims at re-evaluating the influence of intellectual capital through the addition of ownership structure as a control variable. Ownership structure needs to be controlled since, in Indonesia, it is likely to be concentrated due to the low rate of investor protection. Intellectual capital is measured by the VAICTM method, while the market performance is determined by the price to book value ratio. The sample is financial companies listed on Indonesian Stock Market during the 2004-2008 periods. The result of the analysis fails to support the hypothesis that intellectual capital is associated with firm’s values. The result probably is an indication that market is incapable to assess the value of a company’s intellectual capital because it has no standardized measure and the limited quantitative disclosure regarding intellectual capital.

  11. Pengaruh Proporsi Komisaris Independen Dan Komposisi Komite Audit Terhadap Earnings Management (Studi Pada Pyramid Company Di Bursa Efek Indonesia)

    OpenAIRE

    ', Makhdalena

    2012-01-01

    The bankruptcy of giant companies in the early 2000s due to accounting manipulation (earnings management). Earnings management is also happening in companies listed on the Indonesia Stock Exchange. And this makes accounting experts focused on independent commissioners and audit committee. The experts agree that an independent commissioner and the audit committee is an important issue related to earnings management through a substance that can be provided by the independent commissioners and a...

  12. Analisis Faktor-Faktor yang Memengaruhi Dividend Payout Ratio pada Perusahaan Sektor Industri yang Terdaftar di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Sunaryo Sunaryo

    2014-05-01

    Full Text Available The primary objective of this research is to learn the effect among return on assets (ROA, current ratio (CR, debt to equity ratio (DER, debt to total assets (DTA, and net income after tax (NIAT with dividend payout ratio (DPR, either partially or simultaneously. Research used qualitative method with secondary data collected by purposive sampling from industrial companies sector listed in IDX and preceding journals of scientific articles. Research used simple regression to test the hypothesis simultaneously with F test and t test for testing the partial hypothesis. Results of this research describe that return on assets (ROA and net income aftar tax (NIAT have significant effects to dividend payout ratio, but current ratio (CR, debt to equity ratio (DER, and debt to total assets do not have significant effects to dividend payout ratio. It is recommended to further research that the topic of this reseach can be continued using merchandising and distribution company groups, or service company groups either general or special, like: hotels, insurances, hospitals, and banks.

  13. Pengaruh Atribut Perusahaan dan Faktor Audit Terhadap Keterlambatan Audit pada Perusahaan yang Terdaftar di Bursa Efek Malaysia

    Directory of Open Access Journals (Sweden)

    Apriayanti Apriayanti

    2014-01-01

    Full Text Available Audit delay is interval of days between balance sheet date and audit report date. The purpose of this research is to analyze the effect of company attributes and audit factors to audit delay. This research uses 611 companies listed in Malaysian Stock Exchange from the period of 2006 until 2011 as sample. The independent variables used are size of the company, debt to equity ratio, profitability, subsidiaries of multinational companies, audit firm size, audit fees, industry type,  age of company, company financial year end, and audit opinion. The method of analysis in this research is multiple linear regressions. The results of this study shows that size of the company, debt to equity ratio, profitability, subsidiaries of multinational companies, audit firm size, audit fees, industry type, age of company, and audit opinion have significant influence on audit delay while financial year end does not have significant influence on audit delay.

  14. Nutrient status in soil of Ski runs in the sub-alpine belt of Uludag Mountain, Bursa, Turkey.

    Science.gov (United States)

    Guleryuz, Gurcan; Kirmizi, Serap; Arslan, Hulya

    2010-01-01

    Large areas of land are disturbed in sensitive bio-diverse mountain environments by Skiruns. Restoration of vegetation on such disturbed mountain sites may be hampered by soil degradation but the severity and nature of the constraints is not well understood. This study was designed to compare the water holding and nutritional status of soil in three Ski runs which had different construction dates and disturbance levels, and the adjacent undisturbed site in the Abies bommuelleriana forest community in the sub-alpine belt of Uludag Mountain (Bithynian Olympus). The values of soil parameters were depressed in proportion to the disturbance level. Water holding capacity (WHC), total nitrogen (N), organic carbon (C) and calcium (Ca2+), magnesium (Mg2+) and potassium (K+) contents (mg kg(-1) dry weight) of soils in the Ski run which had the highest disturbance level were lower than that of the undisturbed adjacent sites. However the results indicated that the soil parameters were less degraded when secondary vegetation was growing on the disturbed areas.

  15. Pengaruh Risiko Kredit dan Efisiensi Operasional Terhadap Kinerja Perusahaan Perbankan di Bursa Efek Indonesia Periode 2011-2015

    OpenAIRE

    Lumban Batu, Linayanti

    2017-01-01

    The purpuse of this research is to identify and analyze the effect of Capital Adequacy Ratio, Loan to Deposit Ratio, Non Performing Loan, and Operational Expense on Operational Income on the Return on Assets at the banking companies in Indonesia Stock Exchange period 2011-2015. The data used is secondary data obtained from the company's financial statements banking companies listed on the Indonesia Stock Exchange. Data analyzed used descriptive statistical analysis and multiple linear regress...

  16. Pengaruh Return on Assets dan Debt to Equity Ratio terhadap Harga Saham pada Institusi Finansial di Bursa Efek Indonesia

    OpenAIRE

    Rani Ramdhani

    2013-01-01

    This study aims to determine the effect of Return on Assets and Debt to Equity Ratio of Stock Price on Financial Institutions in Indonesia Stock Exchange. This study used secondary data, with samples 2 financial companies in Indonesia Stock Exchange during the study period 2004-2010. Independent variables in this study are Return on Assets and Debt to Equity Ratio. This study used purposive sampling technique. The method of data analysis used classical assumption test, hypothesis test, multip...

  17. The some biological features of carp population (Cyprinus carpio L., 1758 in Lake İznik (Bursa.

    Directory of Open Access Journals (Sweden)

    Hasan Bostan

    2015-12-01

    Full Text Available Bu araştırma İznik Gölü’nde Ocak-Aralık 2006 tarihleri arasında yapılmıştır. Araştırma boyunca 55 erkek, 64 dişi olmak üzere toplam 119 sazan yakalanmıştır. Sazan örneklerinin yaşları I-X, çatal boyları 8.8-70.4 cm, ağırlıkları 14-7362 g arasında değişim göstermiştir. Boy-ağırlık ilişkisi denklemi W=0.025567Lolarak belirlenmiştir. ,kondisyon faktörü dişilerde 1.983±0.097, erkeklerde 1.958±0.070

  18. PERATAAN LABA (INCOME SMOOTHING DAN ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHINYA (STUDI PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA

    Directory of Open Access Journals (Sweden)

    NI LUH PUTU ARIK PRABAYANTI

    2011-01-01

    Full Text Available The aim of this research is to identify factors influencing incomesmoothing. Income smoothing is an active manipulation of earnings toward apredetermined target. The target may be set by the management, requested bythe analysts, or expected by a particular group of stakeholders (Chong, 2006.The factors being examined were size of the company, company’s profitabilityratios, company’s financial leverage ratios, company’s institutional ownershipratio and auditor reputation. Index Eckel is used to determine the incomesmoothing practices.The sample of 41 manufacturers listed on Indonesian StockExchange, during a period between 2004-2008.The hypothesis were tested using binary logistic regression. The firsthypothesis was formulated to consisted examine the effect of size of thecompany on income smoothing. The second hypothesis was formulated toexamine the effect of company’s profitability ratios on income smoothing Thethird hypothesis was to examine the effect of company’s financial leverage onincome smoothing. The fourth hypothesis was formulated to examine the effect ofcompany’s institutional ownership ratio on income smoothing. The fifthhypothesis was to examine the effect of auditor reputation on income smoothing.The result of this research showed that some of the listed manufacturerson Indonesian Stock Exchange committed income smoothing practices. Binarylogistic regression showed that just company’s profitability ratios affect incomesmoothing,while size of the company, company’s financial leverage ratios,company’s institutional ownership ratio and auditor reputation did not affect theincome smoothing.

  19. Analisis Pengaruh Hari Perdagangan dan Nilai Tukar terhadap Indeks Harga Saham Gabungan (IHSG di Bursa Efek Indonesia Tahun 2009

    Directory of Open Access Journals (Sweden)

    Erric Wijaya

    2011-09-01

    Full Text Available Before making investment decisions, investors need to analyze the pattern of trading days which change daily because of investors’ behavior in stock trading activity that affects the pattern of daily stock price movements. Changes in macro variables like exchange rates for instance, also can affect share price. To determine the influence of independent variables (day of the week effect and exchange rate on the dependent variable (Jakarta Composite Index (JCI, a research is conducted using multiple linear regression analysis. The initial test uses a test of normality and is resumed by testing multiple linear regression analysis and classical assumption. The hypothesis test uses t-statistics and F-statistics with a significance level of 5%. A descriptive statistics implies that there is an effect of trading days on stock prices. However, using backward stepwise linier regression model and multivariate analysis, the result indicates that there is no effect of trading days on stock prices. Using multivariate data analysis, it is found that stock prices is influenced by exchange rate.

  20. PENGARUH STRUKTUR MODAL, KEBIJAKAN DIVIDEN DAN SIZE TERHADAP NILAI PERUSAHAAN(Studi Pada Perusahaan Properti Di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Zainal Abidin

    2016-04-01

    Full Text Available Company has a normative goal to maximize the value of the companies, which aims to maximize shareholder wealth. This study aims to analyze the factors that value effect of the company. The variables used in this study are the Debt to Equity Ratio (DER, Dividend Yield (DYD and Size. The research was conducted on property companies listed on the Stock Exchange, period from 2009 to 2011. The dependent variable in this study is measured by the value of the company’s, Price to Book Value (PBV. The independent variable in this study is capital structure is measured by Debt to Equity Ratio (DER, dividend policy as measured by Dividend Yield (DYD and Size. Sampling was conducted using purposive sampling method which produces 17 companies as the  study  of  a  population  sample  of  52  companies.  The  method  used  in  this research is the analysis of linier regression. This  result  showed  by  together  DER,  DYD  and  Size  has  effect  on  PBV.  The partially  DER  indicated  positive  and  significant  effect  of  PBV.  Size  had  no significant positive effect on PBV. DYD has significant effects and negatively to PBV. Keyword : Debt  to  Equity  Ratio  (DER,  Divident  Yield  (DYD,  Size  and  Proce  to  Book Value (PBV

  1. PENGARUH UTANG TERHADAP PROFITABILITAS PADA PERUSAHAAN FOOD & BEVERAGE YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2011-2015

    Directory of Open Access Journals (Sweden)

    Maizah Rosita

    2017-05-01

    Full Text Available The purpose of this research is to determine the effect of The Debt (Long Term Liabilities to Total Assets and Liabilities Total Assets to the return on assets, return on equity and earning per share. The research used secondary data from annual financial report  of Food & Beverage Company from 2011-2015 listed on BEI,  used  purposive sampling method and used multiple regression analysis. Based on the test result of simultan or test F The Long Term Liabilities to Total Assets and Short Term Liabilities is significant to the Return On Assets, Return On Equity and Earning per share. Result of partial test  or T Test, Long Term Liabilities to Total Assets is not significant on Return On assets, Short Term Liabilities to Total Assets is significant on Return on Assets. Long Term Liabilities to Total Assets is not significant to Return On Equity, Short Term Liabilities to Total Assets significant to Return On Equity, Long Term Liabilities to Total Assets in not significant to Earning per share, and Short Term Liabilities to Total assets is significant to Earning per share.

  2. Pengaruh Return on Assets dan Debt to Equity Ratio terhadap Harga Saham pada Institusi Finansial di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Rani Ramdhani

    2013-03-01

    Full Text Available This study aims to determine the effect of Return on Assets and Debt to Equity Ratio of Stock Price on Financial Institutions in Indonesia Stock Exchange. This study used secondary data, with samples 2 financial companies in Indonesia Stock Exchange during the study period 2004-2010. Independent variables in this study are Return on Assets and Debt to Equity Ratio. This study used purposive sampling technique. The method of data analysis used classical assumption test, hypothesis test, multiple regression analysis, the F test and t test. Based on results of the study, Return on Assets and Debt to Equity Ratio have no significant effect on stock price. Meanwhile, the F test result shows that Return on Assets and Debt to Equity Ratio jointly have no effect on stock price.

  3. Pengaruh Mekanisme Corporate Governance Terhadap Peringkat Obligasi Yang Tercatat Di Bursa Efek Indonesia Periode Tahun 2008 – 2010

    Directory of Open Access Journals (Sweden)

    M Mariana

    2016-05-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh mekanisme corporate governance terhadap default risk yang diproksikan dengan peringkat obligasi. Mekanisme corporate governance diproksikan dengan jumlah blockholder, kepemilikan institusi, kepemilikan insider, kualitas audit, komite audit, ukuran dewan komisaris, dan proporsi dewan komisaris independen. Penelitian ini menggunakan leverage, ROA, dan ukuran perusahaan sebagai variable kontrol. Sampel dalam penelitian ini terdiri dari 81 obligasi yang diterbitkan oleh perusahaan yang terdaftar di BEI selama periode 2008-2010 yang telah diperingkat. Penelitian ini menggunakan model analisis ordinal logistic regression untuk menguji pengaruh dari mekanisme corporate governance terhadap peringkat obligasi. Hasil penelitian membuktikan bahwa blockholder, kualitas audit, dan proporsi dewan komisaris independen berpengaruh signifikan terhadap peringkat obligasi. Penelitian ini tidak berhasil membuktikan bahwa kepemilikan institusi, kepemilikan insider, komite audit dan ukuran dewan komisaris berpengaruh secara signifikan terhadap peringkat obligasi.

  4. ANALISIS FAKTOR-FAKTOR YANG BERPENGARUH TERHADAP PEMILIHAN METODE AKUNTANSI PERSEDIAAN PADA PERUSAHAAN MANUFAKTUR DI BURSA EFEK JAKARTA

    Directory of Open Access Journals (Sweden)

    Rosna K. Harahap

    2009-12-01

    Full Text Available The objective of this research is to know whether inventory variability, company size, Leverage, gross profit margin, current ratio, inventory intensity and cost of goods sold variability are factors that influence the choice of inventory accounting method in manufacturing companies listed at Jakarta Stock Exchange. The samples are 36 listed manufactured company at Jakarta Stock Exchange during 2002-2006 which selected using purposive non random sampling. Data analyzed methods used are univariate test using Mann Whitney and t-test and multivariate test using logistic regression method. The result of univariate test is that inventory variability, company size, Leverage, current ratio, inventory intensity and cost of goods sold variability of companies using FIFO method differ than those are from companies using average method. However, gross profit margin of companies using FIFO method is the same as the profit margin of companies using average method. The result of multivariate test shows that company size, current ratio, inventory intensity, and cost of goods sold variability influence the choice of inventory accounting method. In contrary, inventory variability, Leverage, and gross profit margin of companies using FIFO method have no influence to companies using average method. Keywords: Inventory Method, Inventory Variability, Company Size, Leverage, Gross Profit Margin, Current Ratio, Inventory Intensity, Cost of Goods Sold Variability.

  5. Pengaruh Faktor Eksternal Terhadap Nilai Perusahaan (PBV dan Harga Saham Terhadap Perusahaan Manufaktur di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Ni Putu Santi Suryantini

    2015-08-01

    Full Text Available The  aims  of this research  i s  to examine  the  influence  of    external  factors on  f irm  value,   the effect  of   companyvalue  on stock  price,  and influence  of  external factors  on  stock  price. The  samples  were 30  manufacturingcompanies  li sted  in  Indonesia  Stock  Exchange  through  pusposive  sampling.  This  study  applied  secondarydata  based  on  documentation  of the  companies.   Data  analysis  was performed  by  using  Smart  PLS.  Out  of thethree indicators of external factors, two of them i.e.  inflation and exchange rate,  met  the criterion,  becausethey have loading factor above 0,5 .  The resul ts  show that, external factors negatively effect firm value withcoefficient  value  of  0.0933,  means  that  i f  external   factors  changes,  company’ s  value  thr ough  PBV ,  movetowar d  negative  di r ection.  V alue  of  company  influence  stock  price  positively  with  coeff icient  value  of   0.0637.Additionally,  external   factors  show  negat ive  effect   on  stock  price  with  coefficient  value  of  0.1019,  as  anindication that the  changes of  external factor  has negative  impl ication to  the  stock price

  6. Analisis Faktor-faktor Yang Memengaruhi Timeliness Publikasi Laporan Keuangan Periode 2009-2010 (Studi Empiris Pada Bursa Efek Indonesia)

    OpenAIRE

    Sigit Mareta

    2015-01-01

    The purpose of this research is to analyze factors that affect timeliness of theIndonesian public company’s financial statement forwarding. The examined factors of thisresearch are profitability, liquidity, leverage, firms size, auditor opinion, reputation ofpublic accountant, public accountant exchange, and management exchange as independentvariables while timeliness as dependent variable. The Population of this research are allissuer at the Indonesian stock exchange that provides fina...

  7. GEOCHEMICAL CHARACTERISTICS AND RARE-EARTH ELEMENT DISTRIBUTIONS OF KOZBUDAKLAR W-SKARN DEPOSIT (BURSA, WESTERN ANATOLIA)

    OpenAIRE

    ORHAN, Ayşe; MUTLU, Halim

    2017-01-01

    The Kozbudaklar W-skarn deposit occurs along thecontact between Eocene Topuk Granitoid and Triassic İnönü Marble in TavşanlıZone. In the study area, the endoskarn is represented by plagioclase-pyroxeneand exoskarn zone which is characterized by pyroxene, pyroxene-garnet, garnetand garnet-pyroxene skarn facies. According to major oxide element contents,exoskarn is of calcic character. In pyroxene and pyroxene-garnet skarn facies,tungsten and molybdenum abundances vary between 434-5507 ppm (mea...

  8. Analisa Environmental Cost pada Perusahaan Non-Keuangan yang Terdaftar di Bursa Efek Indonesia Periode 2011, 2012 dan 2013

    Directory of Open Access Journals (Sweden)

    Kartike Dewi

    2014-11-01

    Full Text Available Environmental damage due to over-exploitation by employers without thinking about environmental improvements result in long-term environmental damage. Allocation of environmental costs, making high expenses on companies that ultimately will reduce net income. This study will examine companies that have great potential to damage the environment, but the company is willing to make the allocation of environmental costs in its income statement, and the company also wants to follow the PROPER program created by the Ministry of Environment for the period 2011 to 2013. The research was conducted using secondary data in www.idx.co.id and www.proper.menlh.go.id. Financial Statements of the company that made the sample examined by checking whether there is environmental damage costs are allocated and check the results of PROPER (Program Performance Rating. This study will determine whether the company identifying, recognizing, measuring and presenting the cost of environmental damage in the Financial Statements. Results obtained from secondary data is that many companies have yet to identify, acknowledge, measure and present the cost of the destruction of nature in the financial statement, the company may have a cost allocation but still use the Incidental Charges account, so that when the pages are checked through www.idx.co.id charge is not visible. It is expected that in the future the company create its own environmental cost allocation account so that it can be easily identified by users of Financial Statements.

  9. Investigation on limbal stem cell transplantation with sealing fascial bursa clearance to prevent recurrence of pterygium after excision

    Directory of Open Access Journals (Sweden)

    Jian-Hua Yang

    2016-01-01

    Full Text Available AIM:To explore the clinical effect of pterygium excision combined with autologous conjunctiva graft containing corneal limbal stem cells to seal the clearance between conjunctiva and Tenon capsule for the treatment of pterygium.METHODS:Totally 128 eyes of 110 cases underwent pterygium excision with the operation mentioned above. The recovery of corneal epithelium and the recurrence of pterygium were observed after surgeries.RESULTS:The cases were followed up for 12 or 24mo and the pterygium recurrence rate was 2.3% and 3.9% respectively. Corneal epithelium recovered within 2~3d. There were not any complications.CONCLUSION:Pterygium excision combined with autologous conjunctiva graft containing corneal limbal stem cells to seal the clearance between conjunctiva and Tenon capsule has reliable curative effect and the autologous grafts can be easily obtained. This method can significantly reduce recurrence of pterygium and make the appearance and position of lacrimal caruncles normal. It can decrease postoperative inflammation and improve postoperative recovery. It is an ideal method for pterygium treatment.

  10. HUBUNGAN ANTARA FLUKTUASI NILAI TUKAR RUPIAH, SUKU BUNGA DAN HARGA SAHAM INDUSTRI MANUFAKTUR DI BURSA EFEK JAKARTA

    Directory of Open Access Journals (Sweden)

    M. Budiantara

    2016-11-01

    Full Text Available In this study, we examine the relation between exchange rate, interest rate, and stock price of manufacturing industries. Despite Engle-Granger procedure and Johansen Criterion, error correction model (ECM of the two variables is employed to simultaneously estimate the short run and long run dynamics of the variables. Using monthly data covering the May 1996 – September 2003 period, empirical results show that there is a causal relation between variables in the crisis period and before the crisis period. The result of the ECM estimation proves that an increase in stock price of manufacturing industries has a positive effect on the exchange rate, because foreign investors enter the domestic stock market. Depreciation of domestic currency has a negative effect on the stock price. In the crisis period, we can prove that the stock price has a significant effect on the exchange rate variable in the long run. We also prove that the effect of the exchange rate on the stock price only occur in the long run. On the other hand, the result of ECM estimation also proves that an increase in deposit rate has a negative effect on the stock price in the long run and in the short run, because the gain from the deposit would be more than the gain from stock exchange, and we also prove that the stock price of manufacturing industries has a significant effect on the deposit rate variable only in the short run. Keywords: exchange rate, stock price, interest rate, Error Correction Model

  11. ANALISIS PENGARUH MEKANISME CORPORATE GOVERNANCE TERHADAP KINERJA KEUANGAN PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Hamdani .

    2016-04-01

    Full Text Available This  study  was  conducted  to  analyze  the  effect  of  corporate  governance mechanisms, (Ownership Concentration, Size of the Board of Commissioners, Board  Size,  Komisarin  Independent Audit  Committee,  Debt  Policy  and  Firm Size on financial performance. This research was conducted on a manufacturing company in Indonesia Stock Exchange. The population in this study amounted to 148 companies manufacturing and samples were taken of 20 companies with a passing stage purposive sampling. The data used in this research is secondary data. Data taken from the companies listed  in  Indonesia  Stock  Exchange  in  2010-2012  were  obtained  from  the Indonesian  Capital  Market  Director  (ICMD.  Data  collection  techniques using methods of documentation and analysis techniques using multiple linear regression model. Based on the results of hypothesis testing is known that the variable size of the board  of  directors,  audit  committee  and  manufacturing  company  size  has  no effect on CFROA on manufacturing companies in Indonesia Stock Exchange. Sementra  independent  commissioner  terhdap  CFROA  significant  negative effect on manufacturing companies in Indonesia Stock Exchange. Means that the more the number of independent komasaris sekamin lowering CFROA and vice versa. Variable concentration of ownership, board size and debt policies CFROA significant positive effect on the manufacturing company in Indonesia Stock Exchange Keywords: Corporate Governance Mechanisms, CFROA, Ownership Concentration, Size BOC, Size Independent Commissioner Board, Audit Committee, Debt Policy, Company Size

  12. Epilithic diatom assemblages and their relationships with environmental variables in the Nilüfer Stream Basin, Bursa, Turkey.

    Science.gov (United States)

    Karacaoğlu, Didem; Dalkıran, Nurhayat

    2017-05-01

    Patterns of epilithic diatom species distribution in relation to environmental variables from 12 sampling sites on the main stream and some of its tributaries in the Nilüfer Stream Basin were determined using multivariate statistical techniques. The stream basin has been heavily influenced by anthropogenic effects. The upper part of the basin that is distant from pollution sources mostly has a spring water quality, while the lower part where the stream flows through the urban area and receives domestic and industrial wastewater has a quite low quality. Ordination techniques using both diatom taxa and 21 environmental variables revealed non- to slightly polluted upper basin sites and highly polluted lower basin sites along the stream. The results showed that the stream catchment is polluted gradually from upstream to downstream and that most of the downstream sites have very low water quality especially in summer months. A total of 134 epilithic diatom taxa belonging to 50 genera were recorded for 12 sample sites. Partial CCA results indicated that water temperature (T), discharge (Q), and total phosphorus (TP) were the most important variables affecting the distribution of diatom species. Unpolluted or slightly polluted upper basin sites were dominated by Achnanthidium minutissimum, Cocconeis placentula var. euglypta, Gomphonema olivaceum, and Navicula tripunctata. Highly polluted lower basin sites were characterized by high levels of organic and inorganic matters and low dissolved oxygen (DO) values. Species widespread in the highly polluted lower basin sites such as Nitzschia umbonata, Nitzschia amphibia, Nitzschia capitellata, Nitzschia palea, Nitzschia paleacea, Luticola mutica, and Stephanodiscus niagarae were mostly related to pollution indicator variables such as ammonium nitrogen (NH4+-N), sodium (Na+), total phosphorus (TP), and total organic matter (TOM).

  13. Pengaruh Profitability, Leverage dan Firm Size Terhadap Bond Rating pada Perusahaan Nonkeuangan yang Terdaftar di Bursa Efek Indonesia

    OpenAIRE

    Rizky, Widya Irvina

    2016-01-01

    The aim of this study was to identify and analyze the effect of Profitability, Leverage and Firm Size to the Bond Rating in Non-financial Company listed in Indonesia Stock Exchange. This study uses secondary data using a population of 69 companies and 17 companies in the sample during the 2011-2014 period. The variables of this study consisted of Profitability, Leverage and Firm Size as independent variables and Bond Rating as the dependent variable. This study uses Multiple...

  14. Faktor Penentu Pengungkapan Informasi Laporan Keuangan melalui Laman Internet: Studi Empiris pada Perusahaan yang Terdaftar di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Gatot Soepriyanto

    2012-05-01

    Full Text Available The study aims to investigate the factors affecting companies to disclose financial statement information through internet (internet financial reporting. Assessment of the disclosure uses 29 criteria as used by Abdelsalam et al (2007. The method of testing hypotheses in this study is the linear regression method by comparing the extensive disclosure of financial statements on the internet as the dependent variable and type of industry, firm size, profitability, leverage levels and types of auditors as independent variables. Through the observation 69 listed companies in the KOMPAS100 directory, the study concluded that 59.17% of companies meet the criteria for such disclosure made by Abdelsalam et al (2007. Consistent with some previous studies, factors that play an important role on the level of disclosure is the company's size and corporate profitabilty.

  15. Penentuan Struktur Modal Optimal Pada Perusahaan Sektor Properti, Real Estate, dan Kontruksi yang Terdaftar di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    M. Rustam

    2015-04-01

    Full Text Available The purpose of this study is to determine the optimal capital structure of property, real estate, and construction companies listed in Indonesia Stock Exchange. The motivation of this study is due to the current research results are still not able to answer whether the optimal capital structure exists. Based on trade-off theory, the optimal capital structure occurs when a company has a minimum capital cost. However,  it is not explained how much capital structure needed to achieve the company maximum value. In addition, this sample business sector is chosen because there are a numeours firms with an adequate long-term debt which make it possible to examine their capital structure. The method used are the nonlinear regression and Monte Carlo simulation method. These methods were chosen because the formulation of optimal capital structure is arguably complex. There are 47 samples from all property, real estate, and construction companies. The data set covered 11 years ie (2000-2010. The results showed that the optimal capital structure of properties, real estate and construction companies which are measured by the ratio between the long-term debt and equity is 0.99. Most companies of these sectors have not reached the optimal capital structure yet because the average results from these companies are 0.31.

  16. Pengaruh Faktor Internal Dan Eksternal Perusahaan Terhadap Yield to Maturity Obligasi Korporasi Yang Terdaftar Di Bursa Efek Indonesia

    OpenAIRE

    Augustpaosa Nariman

    2016-01-01

    This research is to analyze and obtain empirical evidence about the influence of internal factors and external factors on the yield to maturity of corporate bonds. Internal factors are the company's audit committee, company size, debt to equity ratio while the external factors is the quality of auditors and the interest rate of Bank Indonesia. This research usedsample of 33 companies which issued bonds in 2011-2013. Data were analyzed using multiple linear regressionand prior to hypothesis te...

  17. PENGARUH PER DAN EV/EBITDA TERHADAP HARGA SAHAM PERUSAHAAN PADA INDUSTRI BARANG-BARANG KONSUMSI DI BURSA EFEK JAKATA

    Directory of Open Access Journals (Sweden)

    Dini Onasis

    2016-10-01

    Full Text Available Abstrak: Penjualan saham di pasar modal merupakan salah satu sumber pendanaan bagi suatu perusahaan, bagi seorang investor pasar modal merupakan suatu investasi dalam bentuk saham. Bagi seorang Analisis Saham dan Investor, valuation memainkan peran yang berarti pada analisis fundamental. Analisis Saham dan Investor menggunakan valuation untuk menilai suatu perusahaan, dimana valuation digunakan untuk menentukan harga saham suatu perusahaan under atau overvalued. PER dan EV/EBITDA merupakan salah satu dari metode valuation yang sering digunakan oleh analisis dan investor untuk menilai harga saham suatu perusahaan.Penilitian ini menganalisis PER dan EV/EBITDA dan pengaruhnya terhadap harga saham 33 perusahaan yang telah tercatat pada industri barang-barang konsumsi dari tahun 1999 hingga tahun 2001. Variabel yang diteliti adalah PER, EBITDA dan Harga Saham. Pengujian hipotesis dilakukan dengan Uji F statistik dan Uji t Statistik pada taraf nyata 5 %.Hasil uji Simultan menunjukkan bahwa terdapat pengaruh signifikan dari seluruh variabel PER dan EV/EBITDA terhadap variabel Harga Saham. Berdasarkan hasil analisis yang didapat 68,8 % harga saham dapat dipengaruhi oleh PER dan EV/EBITDA secara bersama-sama. Hasil uji Parsial menunjukkan bahwa terdapat pengaruh signifikan dari EV/EBITDA terhadap harga saham. Sedangkan variabel PER tidak menunjukkan pengaruh yang signifikan. Abstract: The sale of shares in the capital market is one source of funding for a company, for a capital market investors is an investment in shares. For an Analysis of Stocks and Investors, valuation plays a meaningful role in fundamental analysis. Analysis of Stocks and investors use to assess a company valuation, which valuation is used to determine a company's stock price under or overvalued. PER and EV/EBITDA is one of the valuation methods are often used by investors to assess the analysis and stock price of a company.This research analyzes PER and EV/EBITDA and the impact on stock prices of 33 companies that have been recorded in the consumer goods industry from 1999 to 2001. The variables studied were PER, EBITDA and stock price. Hypothesis testing is done by the F test statistic and t test statistics at the 5% significance level.Simultaneous test results indicate that there is significant influence of all the variables PER and EV/EBITDA to variable stock price. Based on the analysis results obtained 68.8% stock price may be affected by PER and EV/EBITDA jointly. Partial assay results indicate that there is significant influence of EV/EBITDA on stock prices. While the PER variables showed no significant effect. Keywords: Saham, EV/EBITDA, PER

  18. Vacunacion contra la enfermedad infecciosa de la Bursa via aspersion y via agua de bebida en pollos de carne

    National Research Council Canada - National Science Library

    Castellanos C., Diana; Icochea D., Eliana; Guzman G., John; Reyna S., Pablo; Perales C., Rosa

    2012-01-01

    .... El Grupo A fue vacunado por la via aspersion y el Grupo B por la via agua de bebida. A los 29 dias de edad, 50 aves de cada grupo fueron trasladados a un galpon experimental para su desafio con la cepa estandar F52/70...

  19. Pengaruh Rasio CAMEL terhadap Pertumbuhan Laba Perbankan yang Go Public di Bursa Efek Indonesia Periode 2010-2013

    OpenAIRE

    Butar-Butar, Ayanti Novalina

    2016-01-01

    This study aims to identify and analyze the influence of the ratio of CAMEL consisting of Capital Adequacy Ratio (CAR), Non Performing Loan (NPL), Net Profit Margin (NPM), Operating Expenses to Operating Income (ROA), and Loan to Deposit Ratio ( LDR), to the profit growth of banking companies that go public in Indonesia Stock Exchange 2010-2013. This study used secondary data obtained from the Indonesia Stock Exchange www.idx.com website and the website of each bank by using a sample of 30 ba...

  20. Analisis Variabel Yang Mempengaruhi Earnings Per Share Pada Industri Food and Baverages Yang Go Public Di Bursa Efek Jakarta

    OpenAIRE

    -, Sutejo -; Swasto, Bambang -; Salim, Ubud -

    2010-01-01

    This research aimed at identifying both the simultaneous and partial influence of such variables as: return on equity (X1), net sales (X2), current ratio (X3), debt to equity (X4), inventory turnover (X5), total assets turnover (X6), and net profit margin (X7), on earnings per share. To examine such influence, this research investigated the food and beverages industries listed at the Jakarta Stock Exchange. The sample investigated included: 9 firms of 1992, 15 firms of 1993, 19 firms of 1994,...

  1. Analisis Variabel yang Mempengaruhi Earnings Per Share pada Industri Food And Baverages yang Go Public di Bursa Efek Jakarta

    OpenAIRE

    -, Sutejo -; Salim, Ubud -; Swasto, Bambang -

    2009-01-01

    This research has as its rationale the fact that investors are willing to invest their money in a particular object of investment (stock) if the latter is able to yield a higher return than provided by other objects of investment. Earnings per share is a main indicator used by investors to examine whether or not a particular stock is profitable. Information resulted from earnings per share is fundamentally useful for the financial decision made by firms whose stock is listed in the stock exch...

  2. Pengaruh Return Saham, Volume Perdagangan dan Varian Return Terhadap Bid-Ask Spread Pada Perusahaan Perbankan di Bursa Efek Indonesia

    OpenAIRE

    Nathanael, Alfredo Amalburga

    2015-01-01

    Bid-ask spread is the spread of bid price and ask price. Bid-ask spread is being use for investor to buy stock in broker. Bid-ask spread in this research is dependent variable. The purpose of this research is to obtain empirical evidence about the effect of stock return, trading volumeandreturn variance to bid-ask spread both partially and simultaneously. The type of this research is quantitative research and the data which was used for this research is secondary data which came fromstock pri...

  3. Temporal and spatial variations in PAH concentrations in the sediment from the Nilufer Creek in Bursa, Turkey.

    Science.gov (United States)

    Karaca, Gizem; Tasdemir, Yücel

    2014-01-01

    The objective of this study was to identify the temporal variations in PAH concentrations in the sediment at different locations on the Nilufer Creek moving along an industrial city. The distribution of various PAH species and their possible sources were determined. Sediment samples were taken from at eight different locations on the Nilufer Creek for a one-year period. Temporal concentration profiles were in the range of 15-9600 ng g(-1) dry matter (dm). PAH concentrations reached their maximum values in the winter (9600 ng g(-1) dm). Molecular diagnostic ratios of PAHs showed that the pollution in the Nilufer Creek in the fall, winter and summer seasons was mostly pyrolytic. It was observed that 3-4 ring species predominated in all seasons in the Nilufer Creek sediment.

  4. Bursitis of the heel

    Science.gov (United States)

    ... heel is swelling of the fluid-filled sac (bursa) at the back of the heel bone. ... A bursa acts as a cushion and lubricant between tendons or muscles sliding over bone. There are bursas around ...

  5. Retrocalcaneal bursitis (image)

    Science.gov (United States)

    Retrocalcaneal bursitis is an inflammation of the bursa at the back of the heel bone. A bursa is a ... bursa to become irritated and inflamed. Symptoms of bursitis include pain in the heel, especially with walking, ...

  6. Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7

    OpenAIRE

    Hayashi, Tomoko; Gray, Christine S.; Chan, Michael; Tawatao, Rommel I.; Ronacher, Lisa; McGargill, Maureen A.; Datta, Sandip K.; Carson, Dennis A.; Corr, Maripat

    2009-01-01

    Activation of Toll-like receptors (TLR) contributes to the initiation and maintenance of chronic inflammation in autoimmune diseases, yet repeated exposure to a TLR agonist can induce hyporesponsiveness to subsequent TLR stimulation. Here, we used a synthetic TLR7 agonist, 9-benzyl-8-hydroxy-2-(2-methoxyethoxy) adenine (SM360320, 1V136) to study TLR7 induced attenuation of inflammatory responses and its application to autoimmune diseases. Repeated low dose administration of this TLR7 agonist ...

  7. ANALISIS PERBEDAAN TINGKAT PROFITABILITAS SEBELUM DAN SESUDAH PENGUNGKAPAN CSR (CORPORATE SOCIAL RESPONSIBILITY PADA PERUSAHAAN DALAM INDUSTRI PERTAMBANGAN DAN FARMASI YANG TERDAFTAR DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Yustina Herry

    2012-11-01

    Full Text Available The main purpose of the company used to gain maximum profits, now has changed with more attention to environmental and social aspects (triple bottom line in order to create balance in the implementation. The research was conducted with the aim to analyze whether there are differences in the level of profitability as seen from the ratio of profitability, namely NPM (Net Profit Margin, ROA (Return on Assets and ROE (Return On Equity both before and after the disclosure of Corporate Social Responsibility. The sample used in this study is companies in the mining and pharmaceutical industries listed in the Indonesia Stock Exchange disclosing CSR in the period of 2003-2008 in the annual report or separate sustainability report. There are 10 samples taken by purposive sampling method, which meets the criteria. Data were analyzed using SPSS 16.0. Hypothesis testing is performed using paired two-sample test (paired sample t-test. The result of research indicates that there are no difference in profitability at the time before and after the disclosure of CSR. 

  8. ANALISIS REAKSI INVESTOR TERHADAP PENGUMUMAN RIGHT ISSUE DI BURSA EFEK JAKARTA (Suatu Pengamatan pada Return, Abnormal Return, Aktivitas Volume Perdagangan dan Bid-Ask Spread Saham

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    SRI DEWI YUSUF

    2012-05-01

    Full Text Available ABSTRACT Development of stock market activity, which grows very fast lead to significant changes on the demand of information quality. To make the rational investor decision making, it is needed a relevant information in order to identify any work of the company. Event study is a study which analyze any market reactions toward an event which the information is published as announcement. Right issue announcement can affect market, it is depent on the existence of the content of the information in the right issue announcement above. If the right issue announcement contains some information so the market will react and the market won’t react if no information. The research sample is determined by a purposive sampling method, and there are 17 companies which announce right issue between 2000-2003. Statistical experiment used is T-test experiment (paired two samples for means. The Observation period which is done in 11 day, consist of 5 day before, 1 day in the moment, and 5 day after the announce right issue. Results show that there is a significant difference between return and abnormal return in the period of between at the moment, and after the announce right issue. The result in the before-after announce right issue period shows that there is no significant difference. The result in the variable activity of stock’s trade volume shows that there is signification difference in the before-at the moment and after period, but in the result of before-after period show that there is no significant difference there. And the result of bid-ask spread variable shows that there is no significant different in the before-at the moment and after period of announce right issue, but in the before-after period the result shows that there is no significant different there. And the result of bid-ask spread variable shows that there is no significant different in the before-at the moment and after period of announce right issue, but in the before-after period the result shows that there is significant different there. Cumulatively, this research gives a conclusion that announcement right issue have no information contents positive so that the market in general give no reaction. Keywords: Right Issue announcement, Return, Abnormal Return, TVA, Bid-Ask Spread

  9. PENGARUH TANGGUNG JAWAB SOSIAL PERUSAHAAN TERHADAP KUALITAS PENGUNGKAPAN INFORMASI TANGGUNG JAWAB SOSIAL DAN DAMPAKNYA PADA NILAI PERUSAHAAN (Studi Empiris Pada Perusahaan Publik Di Bursa Efek Indonesia)

    OpenAIRE

    Ade Adriani

    2016-01-01

    This  research  was  intended  to  examine  :  (1)  the  effect  of  Corporate  Social Responsibility activities (consisting of social responsibility, product responsibility, labor practices responsibility and environmental responsibility) related to the quality  of  social  responsibility  information  disclosures,  and  (2)  the  effect  of Corporate Social Responsibility activities (consisting of social responsibility, product  responsibility,  labor  practices  responsibility,  environmen...

  10. PENGARUH RISIKO SISTEMATIS DAN LIKUIDITAS TERHADAP TINGKAT PENGEMBALIAN SAHAM BADAN-BADAN USAHA YANG GO-PUBLIC DI BURSA EFEK JAKARTA PADA TAHUN 1999

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    Kumianny A.Saputra

    2002-01-01

    Full Text Available Research on determinant variables of rate of return has frequently been undertaken%2C generally with the conclusion that stock risk is very dominant for an investor in making investment decisions in the capital market. But there is another factor that also needs to be considered%2C stock liquidity.%0D%0AThe purpose of this research is to test how systematic risk and stock liquidity%2C measured by the size of the spread between the bid and asked prices%2C influence stock returns of public companies listed on the Jakarta Stock Exchange and to know proportion of each variable%5C%27s influence on the return of individual stocks.%0D%0AThe results from this study show that systematic risk and stock liquidity%2C measured by the size of the spread between the bid and asked prices%2C had a significant effect on the return of individual stocks of public companies in Indonesia. Hypothesis tests for each variable showed that systematic risk had a greater effect on returns than stock liquidity. Abstract in Bahasa Indonesia : Penelitian mengenai variabel-variabel penentu tingkat pengembalian saham yang banyak dilakukan umumnya selalu menyimpulkan bahwa risiko saham sebagai salah satu variabel penentu sangat mendominasi dalam setiap pertimbangan yang dilakukan oleh para investor dalam memutuskan untuk menginvestasikan dananya di pasar modal. Namun sebenarnya ada variabel penentu lain yang juga akan mempengaruhi tingkat pengembalian saham yang perlu dipertimbangkan pula%2C yaitu likuiditas saham. %0D%0ATujuan dari penelitian ini adalah untuk menguji bagaimana pengaruh risiko saham dalam hal ini adalah risiko sistematis dan likuiditas saham yang diukur dengan besarnya bid-ask spread terhadap tingkat pengembalian saham dari badan-badan usaha yang go public di PT.BEJ%2C dan untuk mengetahui seberapa besar proporsi masing-masing variabel dalam mempengaruhi tingkat pengembalian saham.%0D%0AHasil akhir dari penelitian ini menunjukkan bahwa baik risiko sistematis maupun likuiditas saham yang diukur dengan besarnya bid-ask spread mempunyai pengaruh yang signifikan terhadap tingkat pengembalian saham dari badan-badan usaha yang go public di Indonesia. Dari uji hipotesis didapatkan hasil bahwa risiko sistematis lebih mempengaruhi tingkat pengembalian suatu saham dibandingkan dengan likuiditas saham yang diukur dengan besarnya bid-ask spread. systematic+risk%2C+stock+liquidity%2C+bid-ask+spread%2C+stock+return.

  11. Pengaruh Reputasi Auditor dan Mekanisme Corporate Governance Terhadap Integritas Laporan (Studi Empiris Pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia Periode 2008-2010

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    Fitri Damayanti

    2016-02-01

    Full Text Available This study aims to obtain empirical evidence about the effect of auditor reputation, corporate governance mechanism (independent commissioner managerial ownership, institutional ownership to integrity  of financial statement at  the  manufacturer  companies  in  Indonesia.  Integrity  of  financial  statement define as how far a financial statement disclosure shows truth and honest information. Independent variables used in this study were reputation auditor and corporate governance  mechanism  was  analyzed  by  independent  commissioner managerial ownership, institutional ownership. Dependent variable used in this study is integrity of financial statement was analyzed by conservatism. Study’s  sample was  manufacturer  companies  listed  in  Indonesia  Stock Exchange (IDX period among 2008-2010. Data was collected by purposive sampling  method.  Total  56  manufacturer  companies  were  taken  as  study’s sample. The method of analysis of this research used multiple regression. The   results   of   this   research   showed   that   reputation   auditor   and independent   commissioner   had   significant   effect   to   integrity   of   financial statement. Meanwhile, Institutional ownership and managerial ownership had not significant effect to integrity of financial statementDOI: 10.15408/ess.v4i3.2431

  12. Analisis Faktor yang Mempengaruhi Struktur Modal Serta Pengaruhnya Terhadap Harga Saham Perusahaan Real Estate yang Go Public di Bursa Efek Indonesia

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    Ali Kesuma

    2009-01-01

    Full Text Available The main objective of the study is to examine the impact of these factors on capital structure and stock price in indonesian stock exchange. Data is used secondary data that Published in indonesian stock exchange from 2003-2008. this analisys used Structural Euvation Modeling. The result of the study : 1. There are impact of growth sale on capital structure with regression weight 0,19; 2. There are impact profitability on capital structure with regression weight 0,19 3. There are impact of debt ratio on capital structure; 4. There are not impact of growth sales on stock prices; 5. There are not impact of assets structure on stock price with regression weight 0,12; 6. There are impact of profitability on stock price with regression weight 0,53; 7 There are not significant impact of debt ratio on stock price; 8. There are not significant impact of capital structure on stock price.

  13. Pengaruh Reputasi Underwriter, Ukuran Perusahaan, Umur Perusahaan, Profitabilitas terhadap Underpricing Saham pada Penawaran Umum Perdana (IPO) di Bursa Efek Indonesia (BEI) Periode 2009-2012

    OpenAIRE

    Fahtoni, Akhmad Fauzan; Riyadi, Ricky

    2014-01-01

    The purpose of this study was to analyze the effect of underwriter reputation, firm size, firm age, profitability of the underpricing of shares in an Initial Public Offering (IPO) on the Indonesia Stock Exchange (IDX) 2009-2012.This study uses a sampling technique with certain criteria, and obtained 59 samples of 83 companies who signed up in the Indonesia Stock Exchange (IDX). The method of analysis used in this study is the method of multiple linear analysis (Multiple Linear Regression) wit...

  14. ANALISIS PERATAAN LABA ( INCOME SMOOTHING : FAKTOR YANG MEMPENGARUHINYA DAN PENGARUHNYA TERHADAP RETURN DAN RISIKO SAHAM PERUSAHAAN GO PUBLIC DI BURSA EFEK JAKARTA

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    Zulfa Irawati

    2008-06-01

    whether there was risk ( beta difference between smoother aand non smoother. This hypothesis was tested with independent sample t test and concluded that there was no risk (beta difference between smoother and non smoother.

  15. Intra-articular, bursa, and tendon sheath injections: a survey of practice patterns among members of the American College of Rheumatology.

    Science.gov (United States)

    Lazaro, Deana; Alon, Leah; Ramessar, Nina; Cabas-Vargas, Jenny; Shwin, Kyawt; Stefanov, Dimitre G

    2014-03-01

    The objective of this study was to survey members of the American College of Rheumatology (ACR) regarding intra-articular and soft tissue (musculoskeletal [MSK]) injections and to determine if injection techniques vary depending on type of practice and years of experience. A survey was e-mailed to the members of the ACR to obtain demographics of the respondents, MSK injection practices, and adverse events seen. The most common indications for MSK injections were rheumatoid arthritis, osteoarthritis, and bursitis. Written consent and time-out procedures were more common in academic/government practices when compared with private practice. There was variation in the type of corticosteroid used. The most common preparations were methylprednisolone actetate (45.0%), triamcinolone acetonide (26.1%), triamcinolone hexacetonide (22.1%). This survey showed good agreement on the dosage of corticosteroid for MSK injections; however, as years of experience increased, clinicians were more likely to prescribe lower doses for shoulder and knee injections. In this survey of ACR members, we found self-reported differences in the type of corticosteroid used for MSK injections. There was general agreement on frequency of injections, but more experienced practitioners reported using lower doses of corticosteroid.

  16. Pengaruh Corporate Governance, Leverage, Kualitas Audit dan Employee Diff Terhadap Manajemen Laba: Studi Empiris Pada Perusahaan Manufaktur yang Terdaftar Di Bursa Efek Indonesia Tahun 2013

    OpenAIRE

    Ferawati, Yuli

    2015-01-01

    The purpose of this research is to examine the effect of the corporate governance, leverage, audit quality and employee diff on earnings management practices in manufacturing companies listed in Indonesian Stock Exchange in 2013. Corporate governance is measured by institusional ownership, managerial ownership, independen commissioners and audit committee. This research sample was selected by purposive sampling method with 135 companies as population and 95 companies as samples. Analysis meth...

  17. PENGARUH PROFITABILITAS, SOLVABILITAS, REPUTASI AUDITOR, UKURAN PERUSAHAAN, KANDUNGAN LABA, DAN JENIS INDUSTRI PADA KETIDAKTEPATWAKTUAN PUBLIKASI LAPORAN KEUANGAN DI PT BURSA EFEK INDONESIA PERIODE 2007 - 2009

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    MADE GEDE WIRAKUSUMA

    2011-07-01

    Full Text Available The usefulness of financial report would decrease if it is not timely reported. The purpose of this study is to examine the impact of profitability, solvency, auditor reputation, company size, earnings content, and industry type on late publication of financial report on Indonesia Stock Market during period of 2007-2009. The hypotheses are tested using multiple regression technique. The results show that auditor reputation and company size significantly affect the late publication of financial reports of companies listed on Indonesia Stock Market during 2007-2009. Other variables, i.e profitability, solvency, and earnings information content do not affect the late publication. The control variable, industry type, also does not have any impact on the late financial report publication of the listed companies.

  18. Pengaruh Rasio Keuangan Terhadap Return Saham Dengan Kebijakan Dividen Sebagai Variabel Moderating pada Perusahaan Property dan Real Estate yang Terdaftar di Bursa Efek Indonesia

    OpenAIRE

    Pulungan, Nauli Nurul Suhaida

    2016-01-01

    The purpose of this research is to investigate and analyze the effect of financial ratio (current ratio, debt to equity ratio, return on assets, size, fixed assets turn over, andcash flow to debt) simultaneously and partially to the stock return in property and real estate companies listed on the Stock Exchange Indonesia, as well as to indentify and analyze whether the dividend policy as a moderating variable affect correlation variable of current ratio, debt to equity ratio, return on assets...

  19. Analisa Faktor-Faktor yang Mempengaruhi Kebijakan Dividen dengan cash ratio Sebagai Variabel Moderating pada Perusahaan Barang-Barang Konsumsi Di Bursa Efek Indonesia

    OpenAIRE

    Harianja, Hotriado

    2017-01-01

    The purpose of this study was 1) to test and analyze the influence of return on asset, return on equity, growth, long term debt, debt equity ratio, debt to total asset, current ratio, profit, earning per share and cash ratio on dividend policy, 2) to test and analyze the factors influencing dividend policy represented by return on asset, return on equity, profit, long term debt, debt to total asset, and current ratio on the consumption goods registered in the Indonesian Stock Exchange, and 3)...

  20. ANALISIS PENGARUH NILAI TUKAR, TINGKAT SUKU BUNGA DAN INFLASI TERHADAP INDEKS HARGA SAHAM Studi Kasus Pada Perusahaan Properti yang Terdaftar di Bursa Efek Indonesia

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    Umi Mardiyati

    2013-04-01

    Full Text Available This study aims to analyze the effect of variable exchange rates, interest rates and inflation on share prices of listed property sector in Indonesia Stock Exchange. The population in this study is a company incorporated in the listed property sector in Indonesia Stock Exchange (BEI for the period from 2007 to 2011. Samples obtained using purposive sampling method to obtain 48 companies. This study uses Ordinary Least Square analysis to determine the effect of independent variables on the stock price index of the listed property sector in Indonesia Stock Exchange. Based on t test, the exchange rate a significant negative effect on property sector stock price index, while the variable interest rates have a positive but not significant and variable inflation is positive but not significant effect on the property sector stock price index. Results simultaneously with the F test showed that all the independent variables significantly influence the stock price index property sector. So that only the exchange rate has an influence on stock price index of listed property sector in Indonesia Stock Exchange.

  1. Pengaruh Resiko, Kualitas Manajemen, Ukuran dan Likuiditas Bank terhadap Capital Adequacy Ratio Bank-Bank yang Terdaftar di Bursa Efek Indonesia

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    Farah Margaretha

    2011-01-01

    Full Text Available The purposive of this research is to examine the effect of risk, management quality, size and liquidity toward Capital Adequacy Ratio (CAR. This research designed as an explorative research with used purposive sampling method to take the data. Data for this study was collected is publication financial report of banks listed in Indonesian Stock Exchange the period 2003-2008. Statistical analysis by using method of Ordinary Least Square (OLS and Fixed Effect Method. Result of best examination by using method of Fixed Effect Method. The result of research indicated that index risk (risk of asset turnover, management quality, and asset liquidity have the negative impact toward Capital Adequacy Ratio (CAR. While liquidity of liability have the positive impact toward Capital Adequacy Ratio (CAR.

  2. ANALISIS PENGARUH KARAKTERISTIK BANK DAN INFLASI TERHADAP NET INTEREST MARGIN Studi Kasus Pada Bank Konvensional yang Terdaftar di Bursa Efek Indonesia Tahun 2006-2010

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    Taufik Hidayat

    2012-04-01

    Full Text Available This paper investigates the influence of bank’s characteristics and inflation on commercial bank’s interest margins in Indonesia for the 2006-2010 period. The empirical results suggest that bank-specific characteristics, in particular bank capitalization and efficiency have a positive and significant impact on bank’s net interest margins. The bank size and liquidity have a negative and significant impact on bank’s net interest margins. We also find that inflation has a negative and significant impact on net interest margin (at level 10%.

  3. PERBANDINGAN KINERJA KEUANGAN PERUSAHAAN SEBELUM DAN SESUDAH MERGER DAN AKUISISI (PADA PERUSAHAAN PENGAKUISISI YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2004-2006

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    Hamidah Hamidah

    2013-04-01

    Full Text Available The purpose of this study was to examine the differences in the financial performance of the acquirer pre and post mergers and acquisitions. Financial performance is measured with some ratios, Current Ratio (CR, Total Assets Turnover (TATO, Debt Ratio (DR, Return on Assets (ROA, and Price Earnings Ratio (PER. Population of this study included all public company which conducted merger and acquisition(M & A activity in the period 2004-2006. The samples were 10 companies that were taken by purposive sampling method. Analysis of the data used to test hypotheses using Paired Sample t-Test. Empirical results shows that there are no significant difference for DR and TATO in testing 1 year before and 1 year after M & A up to 1 year before and 5 years after M & A. However, CR shows significant difference in test 1 year before with 2, 4, and 5 years after M & A; ROA shows significant difference in test 1 year before with 4 years after M & A; then PER shows significant difference in test 1 year before with 3 years after M & A.

  4. Pengaruh Good Corporate Governance dan Corporate Social Responsibility Terhadap Tindakan Pajak Agresif Pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia Periode 2011 -2013

    OpenAIRE

    Khairunnisak, Indah

    2015-01-01

    This study aims to determine how the influence of Total Board of Commissioners, Board of Directors Number, Number of Audit Committee and Corporate Social Responsibility partially and simultaneously to Aggressive Tax Measures. Types of research by the author is a descriptive study. Data used is secondary data. Data collection techniques by the author is the documentary method of data collection is done by studying the records or documents of the company (secondary data) as well as literatur...

  5. Efek moderasi ukuran perusahaan pada pengaruh debt to equity ratio dan longterm debt to equity ratio terhadap return on equity di Bursa Efek Indonesia

    OpenAIRE

    Basri, Muhammad

    2017-01-01

    PURPOSES - This study aims is to analyze the influence of debt to equity ratio and longterm debt to equity ratio to return on equity. Furthermore, this study aims also is to analyze firm size in moderating the influence of debt to equity ratio and longterm debt to equity ratio to return on equity at retail trade company listed on Indonesia Stock Exchange. METHODS - Type of research used in this research pertained associative approach. Data from 6 retail trading companies listed on the Ind...

  6. MOTIVASI BONUS, PAJAK, DAN UTANG DALAM TINDAKAN MANAJEMEN LABA (STUDI PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2013-2015

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    Novia Fitri Kusumawardani

    2017-10-01

    Full Text Available The objective of the empirical study is to examine and analyze the influence of Bonus Motivation, Tax Motivation, and Debt Motivation in Earning Management. The variables studied are bonus, tax, debt, firm size, and earning management. The sample of this study is the manufacture company that listed in Indonesia Stock Exchange in 2013 until 2015. The sample used in this study were 165 samples. The classical assumption used is normality test, multicollinearity, autocorrelation, and heteroscedasticity test. Hypothesis test used is the coefficient of determination (R ², simultant test (F-test and invidual test(t-test. The results of this study indicate that (1 Bonus Motivation has positive significant influence in earning management. (2 Tax Motivation has positive significant influence in earning management (3 Debt Motivation has positive significant influence in earning management. Keywords: Earning Management, Bonus, Income Tax, Debt to Assets Ratio, Firm Size.

  7. ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PER ANTARA SAHAM YANG TERCATAT DALAM INDEX SYARIAH DAN SAHAM BIASA (Studi pada Perusahaan Non Keuangan di Bursa Efek Indonesia 2006 -2008

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    Ratnaningrum Ratnaningrum

    2011-06-01

    Full Text Available Price Earning ratio (PER shows how much investors are willing to pay per rupiah of reported profit. Since a high PER shows that investor think that the firm has good growth opportunity, so factors determining of PER become very important means to investors in making investment decisions. This study examined the influence of current ratio, debt to equity ratio, return on equity, net profit margin, dividend payout ratio, and inventory turn over  on PER between stock listed in syariah index and common stock of non financial companies in the Indonesia  Stock Exchange (IDX. Samples used in this study consisted on 38 companies listed in IDX and 10 of them listed in Jakarta Islamic Index (JII. The data was analized using regression model and Chow test. The result showed  return on equity has negative influence on the join  PER. This coefficient was contrary with the expectation. This might due to the fact that the PER could increase because of  decreasing of the profit but not from the increasing of the stock price. Other result is a difference of the regression coefficient between stock listed in syariah index and common stock.

  8. Analisis Pengaruh Company Size, Return on Assets, Financial Leverage, dan Operating Leverage terhadap Income Smoothing Practices pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia

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    Auditya Williyarto Pradana

    2012-05-01

    Full Text Available The primary objectives of this research is to learn the amounts of industrial company using income smoothing practices and effecting among company size, return on assets, financial leverage, and operating leverage with income smoothing practices neither simultaneous nor partial. Data secondary collected by industrial companies listed at Indonesian Stock Exchage and the journal preceding research persons. The sesults of this research describe that there are 11 from 31 samples of industrial company using income smoothing practices. Company size, Return on assets, and financial leverage have not any an effecting significant to income smoothing practices, and Operating leverage have an effecting significant to income smoothing practices, but Company size, Return on assets, Financial leverage, and Operating Leverage have the simultaneous effecting significants to income smoothing practices. The topic of this research can be continued using a certain industrial groups or added many new independence variables, because if compared to proceeding research persons who mention the same and differences of its.

  9. MENDETEKSI EARNINGS MANAGEMENT DAN AKUN-AKUN YANG BERPENGARUH (Studi Pada Perusahaan Yang Melakukan Aktivitas Penawaran Saham Perdana Di Bursa Efek Jakarta

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    OTTO - BUDIHARDJO

    2012-05-01

    Full Text Available ABSTRACT Earnings Management (EM is an effort performed by company management as financial report issuer on purpose to influence the readers and stakeholders behavior who rely on financial reports as their primary information source, in accordance with firm managements’ direction.   EM motivations may vary, from remuneration reason, merger and acquisition event, to comply with particular requirement and regulation, to initial public offering (IPO motivation. This study revealed EM effort in IPO event due to management motivation to demonstrate good performance to public before and during such activity. This study took 50 IPO firms listed at Jakarta Stock Exchange (JSX within 1998-2002. EM detection adopted Modified Jones Model as a powerful model to detect EM. Test result proved that EM was occurred on JSX IPO firms as stated by positive discretionary accruals (DA.                  Further study tried to reveal accounts used as EM tools. This study utilized linear regression with DA as fixed variable to indicate EM and predicted accounts on financial reports used as way to do EM as explanatory variables. Such explanatory variables are account receivable, account payable, inventory, accrued liability, accumulated depreciation, expenses (selling and general administrative and other income (expense. Test result showed that only two variables statistically significant to dependent variable, i.e. DA, they were account receivable and account payable. This result supports a study by Marquardt and Wiedman (2002 who found that EM during IPO activity was influenced by account receivable in positive direction. However, this study does not support Wiedyaningdyah (2001 who concluded IPO activity in JSX during 1994-1997 was significantly influenced by liability (leverage. This study recommends investors or any other parties who rely on firm financial report during IPO activity on JSX to behave more conservative on net income as reported by related firms and considers account receivable and account payable as accounts need to be reviewed prior to any economical decision making related to the financial reports. Key words: Earnings Management, Discretionary Accruals, Initial Public Offerings (IPO.

  10. Enfermedad de Gumboro. Histopatología de la Bursa de Fabricio en la enfermedad natural y experimental en pollos de engorde

    OpenAIRE

    E, Babaahmady; R, Joa.-; Julia, Noda.

    2005-01-01

    La Enfermedad de Gumboro, o Enfermedad Infecciosa de la Bolsa de Fabricio (EIBF) es una enfermedad viral, infectocontagiosa de los pollos jóvenes, que puede afectar al pollo de engorde provocando inmunosupresión y mortalidad. Las cepas del virus EIBF se diferencian en su patogenicidad basado en el efecto que producen en los órganos linfoides principalmente la bolsa de Fabricio y como consecuencia la reducida respuesta inmune a infecciones con otros patógenos o vacunas que se aplican. En este ...

  11. Pengaruh Asimetri Informasi dan Tingkat Disclosure Terhadap Biaya Ekuitas Dengan Kepemilikan Manajerial Sebagai Variabel Moderating (Studi Empiris Pada Perusahaan Manufaktur Di Bursa Efek Indonesia

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    Ratri Nurjanati

    2016-01-01

    Full Text Available The objective of this research, the first to analyze the effect information asymmetric toward the cost of equity, the second to analyze the effect level of disclosure toward the cost of equity, and the third to analyze the effect the managerial ownership toward the cost of equity of the manufacturing industry which are listed in Indonesian Stock Exchange (IDX in 2010-2013. This research used samples of 35 manufacturing industry which are listed in Indonesian Stock Exchange. The sample selection method used purposive sampling method. The statistical testing were used by Partial Least Square (PLS. The result of this research indicate that (1 information asymmetry have influences significanctly toward the cost of equity, (2 the level of disclosure don’t have influences significantly toward the cost of equity, and (3 the managerial ownership have influences significantly toward the cost of equity.DOI: 10.15408/ess.v5i2.2339

  12. ANALISIS PERBEDAAN KUALITAS LABA SEBELUM DAN SESUDAH ADOPSI IAS/IFRS DALAM PSAK INSTRUMEN KEUANGAN PADA PERUSAHAAN PERBANKAN YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2009-2014

    OpenAIRE

    Simbolon, Ella Bertania

    2015-01-01

    Konvergensi standar akuntansi internasional (IAS/IFRS) kedalam PSAK dilakukan secara bertahap. DSAK-IAI mewajibkan perusahaan go public di Indonesia menyusun laporan keuangan sesuai standar akuntansi internasional yang dikonvergensi kedalam PSAK. Tujuan dilakukannya penelitian ini adalah untuk memperoleh bukti empiris tentang adanya perbedaan kualitas laba sebelum dan sesudah adopsi IAS/IFRS pada perusahaan perbankan yang terdaftar di BEI. Kualitas laba didasarkan pada tingkat manajemen laba ...

  13. PENGARUH VARIABEL FUNDAMENTAL TERHADAP HARGA SAHAM DAN LABA PER SAHAM (Studi Kasus Pada Industri Properti Yang Go Public di Bursa Efek Jakarta

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    Wahyu Budi Santoso

    2012-05-01

    Full Text Available ABSTRACT This research aims at investigating two issues. First, Whether the several fundamental variables simultantly and partially influence toward the stock price and earning per share on property companies that go public at Jakarta Stock Exchange. Second, Which of several fundamental variables have the most dominant influence either toward the stock price or earning per share. Population used in this research include the entire property companies that go public at Jakarta Stock Exchange with criteria that those companies had the data availibility during 4 periods, those are from the year of 1998 until 2001, from that criteria are obtained about 31 companies where the 24 companies were selected as sample with the simple random sampling technically. The method of analysis is Structural Equation Modelling (SEM. Research results indicate that (1 Simultantly, fundamental indicators have the positive influence toward the stock price (Y1 and earning per share (Y2, these are indicated by positive coefficient for the two variables, however the influence to the earning per share are stronger than to the stock price because its coefficient is bigger than another. In addition, partially there are the significant influence for the variables of earning quality (X7, capital expenditure (X3, gross margin (X4, selling and administration expenses (X5 and inventory (X1 because the p-value are smaller than the 5% significant level, while the variables of account recievable (X2, effective tax rate (X6 and labour force (X9 have not the significant influence. (2 And for the variable of earning quality (X7 has the most dominant influence either to the stock price or earning per share because the p-value is the smallest.   Key Words: Fundamental Analysis, Stock Price, EPS

  14. Ultrasound-guided retro-calcaneal bursa corticosteroid injection for refractory Achilles tendinitis in patients with seronegative spondyloarthropathy: efficacy and follow-up study.

    Science.gov (United States)

    Srivastava, Puja; Aggarwal, Amita

    2016-06-01

    Ultrasound (US)-guided corticosteroid injection has been shown to be safe and effective for varied causes of plantar fasciitis; however, its use for Achilles tendinitis is controversial. We studied the efficacy and changes in US findings at Achilles enthesitis after corticosteroid injection in patients with spondyloarthropathy (SpA). Patients with SpA with symptomatic Achilles enthesitis, refractory to 6 weeks of full-dose NSAIDs, were offered US-guided local corticosteroid injection. Injected entheses were examined by US (both B mode and power Doppler) at baseline and 6 weeks after injection. Standard OMERACT definitions were used to define enthesitis. Achilles tendon thickness >5.29 mm, 2 cm proximal to insertion in long axis, was considered thickened. Twenty-seven symptomatic Achilles tendons (in 18 patients) were injected with 20 mg methylprednisolone under US guidance baseline, and 6-week follow-up US features were compared. All patients reported improvement in pain (VAS) in the affected tendon after injection (p < 0.0001). Simultaneously, improvement in local inflammatory changes were noted, in the form of significant reduction in tendon thickness (p < 0.0001), vascularity (p < 0.0001), peritendinous oedema (p = 0.001), bursitis and bursal vascularity (p < 0.001 and < 0.0001, respectively). There was no change in bone erosions and enthesophyte. None of the patients had tendon rupture or other injection-related complications at 6 weeks of follow-up. US-guided local corticosteroid injection is an effective and safe modality for refractory Achilles enthesitis in patients with SpA and leads to reversion of acute changes at entheseal site.

  15. PENGARUH KEPEMILIKAN INSTITUSIONAL, UKURAN PERUSAHAAN, PROFITABILITAS DAN RISIKO BISNIS TERHADAP KEBIJAKAN HUTANG PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2008-2012

    Directory of Open Access Journals (Sweden)

    Umi Mardiyati

    2014-04-01

    Full Text Available The purpose of this study is to know the effect of Institutional Ownership, Firm Size, Profitability, and Business Risk on Manufacture Firm Debt Policy Listed in Indonesia Stock Exchange. The sample using purposive sampling. The research model in this study employs panel data analysis with fixed effect approach. The empirical results show that institutional ownership and firm size have positive and significant effect on debt policy. ROA have negative significant effect on debt policy, but business risk have negative and not significant effect on debt policy. Simultaneous test showed that institutional ownership, firm size, profitability, and business risk effect the debt policy.

  16. HUBUNGAN FINANCIAL DISTRESS & MEKANISME GCG TERHADAP PELAPORAN AUDIT PADA PERUSAHAAN PERBANKAN YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2005-2010

    Directory of Open Access Journals (Sweden)

    Mario Pratama Putra Riyanda

    2013-03-01

    Full Text Available This study examines the relation between the composition of financially distressed banks, boards of director Committees and institutional ownership to the likelihood of receiving going concern reports. The composition board of director Committees and institutional ownership represent Good Corporate Governance (GCG mechanism in banks. Financial firms were highly regulated, so we combine BAPEPAM regulation and Altman Z score to identify banks that fit for the financial distress category. For banks experiencing financial distress during 2005-2010, by using logistic regression we find that the greater percentage of financial distress in banks, the smaller the probability the Auditor will issue a going concern report. This empirical study did not support role GCG mechanism on Audit reporting. These results can give us a little sight about implementation of GCG in Indonesia specially for financial firm. The contribution will go to support regulators’ concern about financial reporting, firms behavior (financial and non financial firms in making healthy environment with GCG and the need of balancing proportion in ownership structure in form of the composition board committee and institutional ownership to minimize moral hazard .

  17. Analisa Pengaruh Karakteristik Perusahaan terhadap Tingkat Pengungkapan Tanggung Jawab Sosial Perusahaan pada Perusahaan High Profile yang Tercatat di Bursa Efek Indonesia pada Tahun 2005-2007

    Directory of Open Access Journals (Sweden)

    Muhammad Yusuf

    2011-05-01

    Full Text Available This research is to examine corporate social responsibility disclosure and its level in Indonesian companies. Based on a review of previous researches, six independents variables are extracted for a multiple regression analysis. They are company size, profitability, age, leverage, liquidity, and public ownership. The technique for examining multiple regression analysis by using spss 11,5 programs. Samples of this research are 41 high profile companies that listed in Indonesia Stock Exchange in 2005, 2006, and 2007 acquired using purposive sampling method. The results of this research sowed that on significance rate of 5%, the company size, age, leverage, and liquidity has a significance effect with corporate social responsibilities disclosures. While for the profitability and public ownership has no effect with corporate social responsibilities. These results generally coincide with previous research findings on corporate social responsibilities disclosures.

  18. Pengaruh Profitabilitas, Leverage, Growth, Size Terhadap Harga Saham Dengan Pengungkapan Tanggung Jawab Sosial Sebagai Variabel Intervening Pada Perusahaan Yang Terdaftar Di Bursa Efek Indonesia

    OpenAIRE

    Lomboan, Ardi Manuel; Sondakh, Jullie J.; Pontoh, Winston

    2016-01-01

    The more rapidly business development currently rises tight competition among corporate companies, either national or International. Company does not longer become entity that only focuses to itself thus separate from sosial environment, but become the part of the environment so there is an interaction that arises, caused by the positive response from surrounded environment to its existence. This research purpose is to find out the influence of Profitability, leverage, growth, and size to sto...

  19. Pengaruh Profitabilitas, Tangibility, Ukuran Perusahaan, Risiko, Nondebt Tax Shield, dan Pertumbuhan Perusahaan terhadap Struktur Modal pada Perusahaan Manufaktur yang terdaftar di Bursa Efek Indonesia

    OpenAIRE

    Simbolon, Yossi Gemiarsi

    2015-01-01

    Formulation of the problem in this study is to what extend the influence of profitability, tangibility, firm size, risk, nondebt tax shield, and company’s growth to capital structure on manufacturing companies listed in Indonesia Stock Exchange. The purpose of this study was to determine and analyse the influence of profitability, tangibility, firm size, risk, nondebt tax shield, and company’s growth on the company’s capital structure. Hyphotesis in this study is the profitability, tangib...

  20. Penerapan IFRS Dan Pengaruhnya terhadap Keterlambatan Penyampaian Laporan Keuangan: Studi Empiris Perusahana Manufaktur di Bursa Efek Indonesia Periode Tahun 2008-2010

    Directory of Open Access Journals (Sweden)

    Stepvanny Margaretta

    2012-11-01

    Full Text Available There are several factors that affect the company's delay in submitting the financial statements are often referred to as Audit Delay, among others IFRS (International Financial Reporting Standards, firm size, profitability, size public accounting firm, audit opinion, and complexity. One factor that is quite prominent is the application of IFRS that have not been uniform across all companies in Indonesia. It could also lead to Audit Delay. Firm size theoretically means companies bigger scale required to submit financial reports on time. As for profitability, KAP size, and complexity of the audit opinion is also decent enough to be considered as one of the influential factors on Audit Delay. The results of this study indicate that the application of IFRS, profitability, size KAP, audit opinion, and complexity does not have a significant impact on the delay for submission of financial statements. Finaly, a factor that leads to significant effect of time delay submission of financial statements is the size of the company.

  1. Faktor-Faktor yang Mempengaruhi Pengungkapan Corporate Social Responsibility di dalam Laporan Sustainability (Studi Empiris Pada Perusahaan yang listing di Bursa Efek Indonesia Tahun 2010-2013

    Directory of Open Access Journals (Sweden)

    Dita Rohmah

    2016-01-01

    Full Text Available The study aims to examine the effect of corporate governance, firm size, and profitability to corporate social responsibility disclosure in sustainability report. The mechanism of corporate governance used are independent commissioner, institutional ownership, and foreign ownership.This research is a quantitative study using scientific research in the form of positive economics. The nature and type of this research is descriptive with the method used by literature survey. Data used is secondary data obtained from www.idx.co.id and corporate websites. The analytical method used is multiple linear regression analysis with SPSS version 22. The populations in this study are all companies listed on the Indonesia Stock Exchange during the period 2010 until 2013. Samples are taken by purposive sampling method amount 21companies with 4 years observation. Based on the results of multiple regression analysis with a significant level of 5%, the results of this study concluded that: (1 Independent Commissary does not signicantly influence the effect on the disclosure of CSR in the sustainability report with the significant value 0.390 > 0.05. (2 Institutional Ownership has a significant effect on the disclosure of CSR in the sustainability report with the significant value 0.003 < 0.05. (3 Foreign Ownership does not signicantly influence the effect on the disclosure of CSR in the sustainability report with the significant value 0.221 > 0.05. (4 Firm Size has a significant effect on the disclosure of CSR in the sustainability report with the significant value 0.000 < 0.05. (5 Profitability has a significant effect on the disclosure of CSR in the sustainability report with the significant value 0.001< 0.05.DOI: 10.15408/ess.v5i2.2347

  2. Faktor-Faktor Yang Mempengaruhi Struktur Modal (Studi kasus pada Perusahaan Manufaktur yang terdaftar di Bursa Efek Indonesia Periode 2011 – 2014

    Directory of Open Access Journals (Sweden)

    Mukhlan Khariry

    2016-09-01

    Full Text Available This study aimed to analyze and test the effects of firm size, tangible assets, profitability, asset growth, sales growth and financial risks to the capital structure of the companies listed on the Indonesia Stock Exchange period 2011-2014. Methods used in this research was quantitative method using manufacturing companies listed on the Indonesia Stock Exchange (BEI in the period of 2011-2014 as the research population. The samples of 54 companies were selected by using purposive sampling method. The study hypothesis was tested by multiple linear regression which have fulfilled classical assumption test. The results showed that firm size (X1, asset growth (X4, and financial risks (X6 had significant influence with the positive directional effect towards the capital structure. Profitability factor (X3 had significant influence with the negative directional effect towards the capital structure. Meanwhile, the factors of tangible asset (X2 and sales growth (X5 had no significant effect towards the capital structure.   Keywords: Firm size, tangible asset, profitability, asset growth, sales growth,    financial risk and capital structure.

  3. ANALISIS ABNORMAL RETURN SAHAMSEBELUM DAN SESUDAH PENGUMUMAN PERATURAN LOAN TO VALUE KPR(Studi Pada Perusahaan Properti Di Bursa Efek Indonesia

    Directory of Open Access Journals (Sweden)

    Dwi Suharyanto

    2016-04-01

    Full Text Available This study aims to analyze the abnormal stock return of property companies in Indonesia Stock Exchange as a result of the announcement of Bank Indonesia on  the  restriction  of  the  maximum  Loan  to  Value  (LTV  of  the  mortgage loans.  This  study  uses  event  study,  which  observed  the  average  abnormal return over the 10 days prior to the announcement up to 10 days thereafter. The  results  showed  that  there  was  no  signifi cant  difference  between  the abnormal  returns  before  and  after  the  announcement.  However,  there  is  an increase  in  the  number  of  days  that  experienced  abnormal  returns,  ie  2 (two  days  in  the  period before the announcement of a 5 (fi ve days in the period thereafter. While at the moment of announcement there is no abnormal return. This suggests that the effect of the  announcement  was  not  immediately responded by the market, but there is a lag time for the market to react. These conditions may be caused investors do not have the experience to identify and measure the impact of LTV mortgage regulation. Signifi cant  abnormal  return occurs also varies, which is experiencing abnormal gain 3 days and 4 days of having abnormal loss, which shows the confusion in the market so it happened a few times stock price correction. Another possibility for the market considers these policies also have a positive side. Properties company performance may be declining, but the industry would likely have a positive impact in the long run because it will reduce the risk of price bubbles. Keyword : Abnormal Return, Event Study, Mortgage Loan, Loan to Value.

  4. PENGARUH MANAJEMEN ASET, MANAJEMEN LIABILITI, MANAJEMEN ASET LIABILITI TERHADAP ECONOMIC VALUE ADDED (EVA PADA PERBANKAN KONVENSIONAL YANG TERDAFTAR DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    H Hamidah

    2013-08-01

    Full Text Available Generally, company wants to optimize its profit. Properly manage the asset management, liability management and asset liability management can provide value added profits for the company. A sample of research consists of 18 banking companies listed at Indonesia Stock Exchange (IDX during the 2005-2009. This research investigate the relationship net loans/total earning assets (NLA, non performing loan (NPL, liabilities/total assets (LA, equity/total assets (EA, net interest margin (NIM, loan to deposite ratio (LDR on economic value added (EVA. The research use regression of panel data. The result show that net loans/total earning assets (NLA, liabilities/total assets (LA, equity/total assets (EA, net interest margin (NIM, loan to deposite ratio (LDR are have significant effect on economic value added (EVA but non performing loan (NPL.

  5. PENGARUH INTELLECTUAL CAPITAL TERHADAP KINERJA KEUANGAN PADA PERUSAHAAN RETAIL YANG TERDAFTAR DI BURSA EFEK INDONESIA (BEI PADA TAHUN 2009 – 2011

    Directory of Open Access Journals (Sweden)

    Nono Supriatna

    2013-04-01

    Full Text Available The research aims to examine the influence of intellectual capital to company’s financial performance (profitability, productivity, and market valuation. Profitability measured by Return On Asset (ROA, productiviy measured by Asset Turn Over (ATO, and market valuation measured by Market to Book Value (MB. Independent variabel used in this research is intellectual capital which measured by VAIC™, while dependent variable are ROA, ATO, and MB. In this research, the authors used a quantitative verificative. Data obtainable from retail company listed in Indonesia Stock Exchange (IDX year period 2009-2011. The samples in this research using the method of purposive. Based on sampling criteria the final sample in this research is 7 retail companies. This research use simple linear regression for data analysis. From the research that has been done shows that intellectual capital has positive influence to profitability, intellectual capital has negative influence to productivity, and intellectual capital has no effect to market valuation.

  6. Faktor-FaktorYang Mempengaruhi Perataan Laba Pada Perusahaan Laba (Income Smoothing) Pada Perusahaan Manufaktur Yang Terdaftar Di Bursa Efek Indonesia

    OpenAIRE

    Sitinjak, Gold Naro

    2011-01-01

    The purpose of this research is to know the influence of financial leverage (DAR)) and total assets turnover (TATO)either partially or simultaneously toward earning per share in plantations and minning firms on Indonesia Stocks Exchange. This research is classified as causal research with 18 plantations and minning firms listed in Indonesia Stocks Exchange during 2006 to 2009. The sample selection using purposive sampling method. This research utilizes external data, those are take...

  7. Pengaruh Financial Leverage dan Total Assets Turnover Terhadap Earning Per Share (EPS) Pada Perusahaan Perkebunan dan Pertambangan yang Terdaftar di Bursa Efek Indonesia (BEI) Periode 2006 - 2009

    OpenAIRE

    Armaya, Dwi

    2010-01-01

    The purpose of this research is to know the influence of financial leverage (DAR)) and total assets turnover (TATO)either partially or simultaneously toward earning per share in plantations and minning firms on Indonesia Stocks Exchange. This research is classified as causal research with 18 plantations and minning firms listed in Indonesia Stocks Exchange during 2006 to 2009. The sample selection using purposive sampling method. This research utilizes external data, those are take...

  8. Pengaruh Kebijakan Dividen, Earning Volatility, dan Leverage terhadap Volatilitas Harga Saham pada Perusahaan Non-financing yang Terdaftar di Bursa Efek Indonesia Tahun 2010-2014

    OpenAIRE

    Jannah, Raudhatul; Haridhi, Musfiari

    2016-01-01

    The research examines the effect of dividend policy, earnings volatility, and leverage on share price volatility of non financing companies listed in Indonesia Stock Exchange in 2010-2014. Dividend policy variabel using dividend payout ratio and leverage variabel using debt to equity ratio. Secondary data were sourced from the financial statements, published by the capital market reference center at the Indonesia Stock Exchange. The research type used in this research is hypothesis testing, b...

  9. ANALISIS BOOK TAX DIFFERENCES TERHADAP PERSISTENSI LABA DAN LABA AKRUAL SEBAGAI VARIABEL MODERATING PADA PERUSAHAAN YANG TERDAFTAR DI BURSA EFEK INDONESIA

    Directory of Open Access Journals (Sweden)

    Bety Pramitasari

    2016-10-01

    Full Text Available The research aims at examining the role of book tax differences to the persistence of earnings and earnings of accruals as moderate variable. This research also include control variable, that is industial factor. The hypothesis alternative is (1a large positive book tax differences influence to  the less persistence of earning; (1b large negative book tax differences influence to the less persistence of earning; (2a large positive book tax differences releated to earning of accruals caused the less persistence of earnings; (2b large negative book tax differences releated to earning of accruals caused the less persistence of earnings. The sample of this reaserch was all companies listed Indonesian Stock Exchange (ISX within the period of 2000-2006. The data ware collected using purposive sampling method, that is taked with based on specific.  The amount of the sample was 50 companies with 160 data to be analyzed. This statistic method used multiple regression. The results of this research showed that large positive (negative book tax differences does not influence to the less persistence of earning. Large positive (negative book tax differences releated to earning of accruals does not cause the less persistence of earnings. The conclusion of the research is information in book tax differences can not measure persistence of earnings and information in accrual of earnings in book tax differences can not measure persistence of earning, so the information in book tax differences can not use to measure future earning  performence.

  10. Analisis Teknikal Indikator Stochastic Oscillator Dalam Menentukan Sinyal Beli Dan Sinyal Jual Saham (Studi Pada Sub Sektor Konstruksi Dan Bangunan Di Bursa Efek Indonesia Periode 2014-2016)

    OpenAIRE

    Mutmainah, Mutmainah; Sulasmiyati, Sri

    2017-01-01

    The purpose of this research is to test the accuracy of technical analysis by using Stochastic Oscillator to determine buy and sell signal on Building Construction Company from 2014 to 2016. This research uses descriptive method with quantitativ approach. The population of this research are Construction and Building companies listed in Indonesian Stock Exchange. The sample of this research are selected by applying purposive sampling method, which obtained 9 companies from 12 companies are s...

  11. How parental attitudes affect the risky computer and Internet usage patterns of adolescents: a population-based study in the Bursa District of Turkey.

    Science.gov (United States)

    Uncu, Yeşim; Vural, Pinar; Büyükuysal, Cağatay; Alper, Züleyha; Kiliç, Emine Zinnur

    2014-12-01

    We aimed to evaluate the computer usage patterns of adolescents and to determine the effects of family life and parental attitude on these patterns. This was a descriptive, cross-sectional, population-based survey that included 935 children between 11 and 16 years of age who were students in the second level of primary school and their parents as well. The following instruments were used in the survey: student and parent questionnaires on computer usage patterns and the Parental Attitude Research Instrument (PARI) to assess parental attitudes towards child-rearing and family life. Of the study population, the majority of the students had a computer in their homes and spent a lot of time on the Internet. Parental control over the amount of time spent on the Internet and the websites that were visited had sometimes limited and contradictory effects on computer usage among the students. A democratic parental attitude was the best approach. Using the computer as a reward or punishment had a negative impact on the children's computer usage patterns. Although parents are confused concerning the benefits and harms of the Internet for their children and not certain how to manage their children's use of the computer and safe navigation of the Internet, a democratic parental attitude appears to be the best approach for reaching the most beneficial computer usage patterns for students.

  12. Interleukin-7 and Toll-like receptor 7 induce synergistic B cell and T cell activation

    OpenAIRE

    Bikker, A.; Kruize, A.A.; Wurff-Jacobs, K.M.; Peters, R.P.; Kleinjan, M.; Redegeld, F.A.M.; de Jager, W.; Lafeber, F.P.J.G.; van Roon, J.A.G.

    2014-01-01

    OBJECTIVES: To investigate the potential synergy of IL-7-driven T cell-dependent and TLR7-mediated B cell activation and to assess the additive effects of monocyte/macrophages in this respect. METHODS: Isolated CD19 B cells and CD4 T cells from healthy donors were co-cultured with TLR7 agonist (TLR7A, Gardiquimod), IL-7, or their combination with or without CD14 monocytes/macrophages (T/B/mono; 1 : 1 : 0,1). Proliferation was measured using 3H-thymidine incorporation and Ki67 expression. Acti...

  13. Shoulder Pain

    Science.gov (United States)

    ... Another common cause is soreness of the subacromial bursa (a sac of fluid under the highest part ... improve the blood flow to the tendon or bursa. The blood flow will help reduce soreness. Smokers ...

  14. True bursal pigmented villonodular synovitis

    Energy Technology Data Exchange (ETDEWEB)

    Abdelwahab, Ibrahim Fikry [Department of Radiology, New York Methodist Hospital, Affiliated with New York Hospital-Cornell Medical Center, Brooklyn, NY (United States); Kenan, Samuel [Department of Orthopedics, New York University Medical Center, NY (United States); Steiner, German C. [Department of Pathology, Hospital for Joint Diseases/Orthopedic Institute, New York, NY (United States); Abdul-Quader, Mohammed [Department of Radiology, New York Presbyterian Hospital, Columbia University, New York, NY (United States)

    2002-06-01

    We describe two cases of pigmented villonodular synovitis affecting true bursae. This study was also designed to discuss the term ''pigmented villonodular bursitis'', not confined to true synovial bursae, sometimes creating misunderstanding. (orig.)

  15. A Mouse Model to Investigate Postmenopausal Biology as an Etiology of Ovarian Cancer

    Science.gov (United States)

    2008-11-01

    mice will be injected into the ovarian bursa with Adv-cre to delete p53 and Adv-lacZ as controls in the ovarian surface epithelial cells. Currently...injection into ovarian bursa has been well established, and Adv-cre injection has been successfully used in several mouse models of ovarian tumors...surface and the bursa inner layer of cells (Figure 5). We conclude that adenoviral delivery of cre into ovarian bursa is efficient and technically

  16. Copy Number Variation of Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico

    Directory of Open Access Journals (Sweden)

    Guillermo Valencia Pacheco

    2014-01-01

    Full Text Available Systemic lupus erythematosus (SLE is a systemic autoimmune disease characterized by the production of autoantibodies against self-antigens, which occurs most often in women between 15 and 40 years of age. The innate immunity is involved in the pathogenesis of SLE through TLR-7. Genetic factors such as copy number variation (CNV of target genes may contribute to disease development, but this possible risk has not yet been studied in SLE patients from Yucatan, Mexico. The CNV of TLR-7 gene was determined by quantitative polymerase chain reaction assay using TaqMan probes in 80 SLE women and 150 control subjects. The results showed that 10% of SLE patients exhibited more than two copies of TLR-7 gene, whereas no mRNA overexpression was detected. These data suggested that increased CNV of the TLR-7 gene in Yucatan SLE women can be a risk factor for this disease.

  17. Bacille Calmette-Guerin can induce cellular apoptosis of urothelial cancer directly through toll-like receptor 7 activation

    Directory of Open Access Journals (Sweden)

    Dah-Shyong Yu

    2015-08-01

    Full Text Available Immunotherapy using bacille Calmette-Guerin (BCG instillation is the mainstay treatment modality for superficial urothelial cancer (UC through toll-like receptor (TLR activation of cognitive immune response. We investigated the roles of TLR7 in the activation of apoptosis in UC cells after BCG treatment. The in vitro cytotoxicity effect of BCG on UC cells was measured by a modified 3-(4,5-dimethylthiazo-2-yl-2,5-diphenyl tetrazolium assay. Expressions of TLR7 mRNA and protein in native UC cells prior to and after BCG treatment were analyzed using real-time quantitative polymerase chain reaction and western blot methods. Phagocytotic processes after BCG treatment in UC cells were observed microscopically using a specific immunostain, subsequent cellular apoptosis-related signals induced by TLR7 were analyzed by western blot. Low-grade UC cells, TSGH8301, showed significant cellular death (4.23-fold higher than the high-grade UC cells T24 and J82 when treated with BCG and the BCG cytotoxicity was displayed in a dose–time-dependent manner. TSGH8301 cells had the highest content of TLR7 mRNA, 7.2- and 4.5-fold higher than that of T24 and J82 cells, respectively. TLR7 protein expression was also significantly increased in TSGH8301 cells. Phagocytosis-related markers, including beclin 1, ATG2, and LC3, were increased when TSGH8301 cells were treated by BCG. Interleukin-1 receptor-associated kinases 2 and 4 were also increased markedly in TSGH8301 cells. On the contrary, cellular apoptosis of TSGH8301 cells decreased by 34% when TLR7 activation was suppressed by the TLR antagonist IRS661 after BCG treatment. Our findings suggest that well differentiated TCC cells have higher expression of TLR7 and BCG can drive cellular death of TCC cells directly via TLR7 activation and related apoptotic pathway.

  18. Topical Resiquimod Protects against Visceral Infection with Leishmania infantum chagasi in Mice

    OpenAIRE

    Craft, Noah; Birnbaum, Ron; Quanquin, Natalie; Erfe, Marie Crisel B.; Quant, Cara; Haskell, Jacquelyn; Bruhn, Kevin W.

    2014-01-01

    New prevention and treatment strategies are needed for visceral leishmaniasis, particularly ones that can be deployed simply and inexpensively in areas where leishmaniasis is endemic. Synthetic molecules that activate Toll-like receptor 7 and 8 (TLR7/8) pathways have previously been demonstrated to enhance protection against cutaneous leishmaniasis. We initially sought to determine whether the TLR7/8-activating molecule resiquimod might serve as an effective vaccine adjuvant targeting viscera...

  19. Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia

    OpenAIRE

    Hatchwell, Luke; Collison, Adam; Girkin, Jason; Parsons, Kristy; Li, Junyao; Zhang, Jie; Phipps, Simon; Knight, Darryl; Bartlett, Nathan W; Johnston, Sebastian L; Foster, Paul S; Wark, Peter A B; Mattes, Joerg

    2015-01-01

    Background Asthma exacerbations represent a significant disease burden and are commonly caused by rhinovirus (RV), which is sensed by Toll-like receptors (TLR) such as TLR7. Some asthmatics have impaired interferon (IFN) responses to RV, but the underlying mechanisms of this clinically relevant observation are poorly understood. Objectives To investigate the importance of intact TLR7 signalling in vivo during RV exacerbation using mouse models of house dust mite (HDM)-induced allergic airways...

  20. Interleukin-7 and Toll-like receptor 7 induce synergistic B cell and T cell activation.

    Directory of Open Access Journals (Sweden)

    Angela Bikker

    Full Text Available OBJECTIVES: To investigate the potential synergy of IL-7-driven T cell-dependent and TLR7-mediated B cell activation and to assess the additive effects of monocyte/macrophages in this respect. METHODS: Isolated CD19 B cells and CD4 T cells from healthy donors were co-cultured with TLR7 agonist (TLR7A, Gardiquimod, IL-7, or their combination with or without CD14 monocytes/macrophages (T/B/mono; 1 : 1 : 0,1. Proliferation was measured using 3H-thymidine incorporation and Ki67 expression. Activation marker (CD19, HLA-DR, CD25 expression was measured by FACS analysis. Immunoglobulins were measured by ELISA and release of cytokines was measured by Luminex assay. RESULTS: TLR7-induced B cell activation was not associated with T cell activation. IL-7-induced T cell activation alone and together with TLR7A synergistically increased numbers of both proliferating (Ki67+ B cells and T cells, which was further increased in the presence of monocytes/macrophages. This was associated by up regulation of activation markers on B cells and T cells. Additive or synergistic induction of production of immunoglobulins by TLR7 and IL-7 was associated by synergistic induction of T cell cytokines (IFNγ, IL-17A, IL-22, which was only evident in the presence of monocytes/macrophages. CONCLUSIONS: IL-7-induced CD4 T cell activation and TLR7-induced B cell activation synergistically induce T helper cell cytokine and B cell immunoglobulin production, which is critically dependent on monocytes/macrophages. Our results indicate that previously described increased expression of IL-7 and TLR7 together with increased numbers of macrophages at sites of inflammation in autoimmune diseases like RA and pSS significantly contributes to enhanced lymphocyte activation.