WorldWideScience

Sample records for vessel wall shear

  1. Development of a system for measuring wall shear stress in blood vessels using magnetic resonance imaging and computational fluid dynamics

    International Nuclear Information System (INIS)

    Yoshida, Keita; Nagao, Taisuke; Okada, Kouji; Miyazaki, Shohei; Yang, Xiaomei; Yamazaki, Youichi; Murase, Kenya

    2008-01-01

    We developed a system for measuring the wall shear stress (WSS) in blood vessels using magnetic resonance imaging (MRI) and computational fluid dynamics (CFD). The time-dependent velocity at the center of the blood vessel was measured by phase-contrast MRI and was approximated by finite Fourier series, which was used for generating the velocity profile at the inlet for the boundary condition to the CFD method. To validate the CFD method, we compared the WSS obtained by the CFD method with the theoretical value in a straight cylinder with various radii for both steady and pulsatile flows. We also investigated the dependence of the WSS on the inlet velocity profile incorporated into the CFD method. For steady flow, there was a good agreement between the WSS obtained by the CFD method and the theoretical value. For pulsatile flow, there was a relatively good agreement between them when the radius of the cylinder was 2.5 mm and the inlet velocity profile was given by the Womersley solution for fully developed pulsatile flow in a straight circular cylinder. When the radius of the cylinder was 5 mm and/or the inlet velocity profile was assumed to be parabolic, large differences were observed between them, suggesting that the assumption of fully developed flow does not hold true in these cases. In human studies, the vortex due to the secondary blood flow in the carotid arterial sinus was clearly observed. The WSS in the bifurcation was the highest, while that in the carotid arterial sinus was the smallest. In conclusion, the system presented here appears to be useful for measuring the WSS in blood vessels and for analyzing the cause and/or extent of atherosclerosis, and our results suggest that the inlet velocity profile should be carefully considered. (author)

  2. Rôle of contrast media viscosity in altering vessel wall shear stress and relation to the risk of contrast extravasations.

    Science.gov (United States)

    Sakellariou, Sophia; Li, Wenguang; Paul, Manosh C; Roditi, Giles

    2016-12-01

    Iodinated contrast media (CM) are the most commonly used injectables in radiology today. A range of different media are commercially available, combining various physical and chemical characteristics (ionic state, osmolality, viscosity) and thus exhibiting distinct in vivo behaviour and safety profiles. In this paper, numerical simulations of blood flow with contrast media were conducted to investigate the effects of contrast viscosity on generated vessel wall shear stress and vessel wall pressure to elucidate any possible relation to extravasations. Five different types of contrast for Iodine fluxes ranging at 1.5-2.2gI/s were modelled through 18G and 20G cannulae placed in an ideal vein at two different orientation angles. Results demonstrate that the least viscous contrast media generate the least maximum wall shear stress as well as the lowest total pressure for the same flow rate. This supports the empirical clinical observations and hypothesis that more viscous contrast media are responsible for a higher percentage of contrast extravasations. In addition, results support the clinical hypothesis that a catheter tip directed obliquely to the vein wall always produces the highest maximum wall shear stress and total pressure due to impingement of the contrast jet on the vessel wall. Copyright © 2016 IPEM. Published by Elsevier Ltd. All rights reserved.

  3. Motional Effect on Wall Shear Stresses

    DEFF Research Database (Denmark)

    Kock, Samuel Alberg; Torben Fründ, Ernst; Yong Kim, Won

    Atherosclerosis is the leading cause of death and severe disability. Wall Shear Stress (WSS), the stress exerted on vessel walls by the flowing blood is a key factor in the development of atherosclerosis. Computational Fluid Dynamics (CFD) is widely used for WSS estimations. Most CFD simulations...... are based on static models to ease computational burden leading to inaccurate estimations. The aim of this work was to estimate the effect of vessel wall deformations (expansion and bending) on WSS levels....

  4. Investigation of radial shear in the wall-base juncture of a 1:4 scale prestressed concrete containment vessel model

    Energy Technology Data Exchange (ETDEWEB)

    Dameron, R.A.; Rashid, Y.R. [ANATECH Corp., San Diego, CA (United States); Luk, V.K.; Hessheimer, M.F. [Sandia National Labs., Albuquerque, NM (United States)

    1998-04-01

    Construction of a prestressed concrete containment vessel (PCCV) model is underway as part of a cooperative containment research program at Sandia National Laboratories. The work is co-sponsored by the Nuclear Power Engineering Corporation (NUPEC) of Japan and US Nuclear Regulatory Commission (NRC). Preliminary analyses of the Sandia 1:4 Scale PCCV Model have determined axisymmetric global behavior and have estimated the potential for failure in several areas, including the wall-base juncture and near penetrations. Though the liner tearing failure mode has been emphasized, the assumption of a liner tearing failure mode is largely based on experience with reinforced concrete containments. For the PCCV, the potential for shear failure at or near the liner tearing pressure may be considerable and requires detailed investigation. This paper examines the behavior of the PCCV in the region most susceptible to a radial shear failure, the wall-basemat juncture region. Prediction of shear failure in concrete structures is a difficult goal, both experimentally and analytically. As a structure begins to deform under an applied system of forces that produce shear, other deformation modes such as bending and tension/compression begin to influence the response. Analytically, difficulties lie in characterizing the decrease in shear stiffness and shear stress and in predicting the associated transfer of stress to reinforcement as cracks become wider and more extensive. This paper examines existing methods for representing concrete shear response and existing criteria for predicting shear failure, and it discusses application of these methods and criteria to the study of the 1:4 scale PCCV.

  5. Investigation of radial shear in the wall-base juncture of a 1:4 scale prestressed concrete containment vessel model

    International Nuclear Information System (INIS)

    Dameron, R.A.; Rashid, Y.R.; Luk, V.K.; Hessheimer, M.F.

    1998-04-01

    Construction of a prestressed concrete containment vessel (PCCV) model is underway as part of a cooperative containment research program at Sandia National Laboratories. The work is co-sponsored by the Nuclear Power Engineering Corporation (NUPEC) of Japan and US Nuclear Regulatory Commission (NRC). Preliminary analyses of the Sandia 1:4 Scale PCCV Model have determined axisymmetric global behavior and have estimated the potential for failure in several areas, including the wall-base juncture and near penetrations. Though the liner tearing failure mode has been emphasized, the assumption of a liner tearing failure mode is largely based on experience with reinforced concrete containments. For the PCCV, the potential for shear failure at or near the liner tearing pressure may be considerable and requires detailed investigation. This paper examines the behavior of the PCCV in the region most susceptible to a radial shear failure, the wall-basemat juncture region. Prediction of shear failure in concrete structures is a difficult goal, both experimentally and analytically. As a structure begins to deform under an applied system of forces that produce shear, other deformation modes such as bending and tension/compression begin to influence the response. Analytically, difficulties lie in characterizing the decrease in shear stiffness and shear stress and in predicting the associated transfer of stress to reinforcement as cracks become wider and more extensive. This paper examines existing methods for representing concrete shear response and existing criteria for predicting shear failure, and it discusses application of these methods and criteria to the study of the 1:4 scale PCCV

  6. Modeling of shear wall buildings

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, A K [North Carolina State Univ., Raleigh (USA). Dept. of Civil Engineering

    1984-05-01

    Many nuclear power plant buildings, for example, the auxiliary building, have reinforced concrete shear walls as the primary lateral load resisting system. Typically, these walls have low height to length ratio, often less than unity. Such walls exhibit marked shear lag phenomenon which would affect their bending stiffness and the overall stress distribution in the building. The deformation and the stress distribution in walls have been studied which is applicable to both the short and the tall buildings. The behavior of the wall is divided into two parts: the symmetric flange action and the antisymmetry web action. The latter has two parts: the web shear and the web bending. Appropriate stiffness equations have been derived for all the three actions. These actions can be synthesized to solve any nonlinear cross-section. Two specific problems, that of lateral and torsional loadings of a rectangular box, have been studied. It is found that in short buildings shear lag plays a very important role. Any beam type formulation which either ignores shear lag or includes it in an idealized form is likely to lead to erroneous results. On the other hand a rigidity type approach with some modifications to the standard procedures would yield nearly accurate answers.

  7. Shear buckling of cylindrical vessels benchmark exercise

    International Nuclear Information System (INIS)

    Dostal, M; Austin, N.; Combescure, A.; Peano, A.; Angeloni, P.

    1987-01-01

    In Liquid Metal Fast Breeder Reactors (LMFBR) potential shear buckling failures of the primary vessel, induced through seismic excitations, have to be considered. The problem is particularly severe in pool type reactors due to their large size, radius of approximately 10 m, coupled with small wall thicknesses of 50 mm and less. The object of this paper is to provide a comparison of three different computer codes capable of performing buckling analyses and to demonstrate on practical problems the level of accuracy that may be expected in design analyses. Three computer codes were examined ABAQUS, CASTEM (INCA/BILBO) and NOVNL and the computer results were compared directly with experimental data and other commonly used empirical formula. The joint effort was co-ordinated through the CEC Working Group on Codes and Standards AG2. (orig./GL)

  8. Shear wall ultimate drift limits

    International Nuclear Information System (INIS)

    Duffey, T.A.; Goldman, A.; Farrar, C.R.

    1994-04-01

    Drift limits for reinforced-concrete shear walls are investigated by reviewing the open literature for appropriate experimental data. Drift values at ultimate are determined for walls with aspect ratios ranging up to a maximum of 3.53 and undergoing different types of lateral loading (cyclic static, monotonic static, and dynamic). Based on the geometry of actual nuclear power plant structures exclusive of containments and concerns regarding their response during seismic (i.e.,cyclic) loading, data are obtained from pertinent references for which the wall aspect ratio is less than or equal to approximately 1, and for which testing is cyclic in nature (typically displacement controlled). In particular, lateral deflections at ultimate load, and at points in the softening region beyond ultimate for which the load has dropped to 90, 80, 70, 60, and 50 percent of its ultimate value, are obtained and converted to drift information. The statistical nature of the data is also investigated. These data are shown to be lognormally distributed, and an analysis of variance is performed. The use of statistics to estimate Probability of Failure for a shear wall structure is illustrated

  9. Low-rise shear wall failure modes

    International Nuclear Information System (INIS)

    Farrar, C.R.; Hashimoto, P.S.; Reed, J.W.

    1991-01-01

    A summary of the data that are available concerning the structural response of low-rise shear walls is presented. This data will be used to address two failure modes associated with the shear wall structures. First, data concerning the seismic capacity of the shear walls with emphasis on excessive deformations that can cause equipment failure are examined. Second, data concerning the dynamic properties of shear walls (stiffness and damping) that are necessary to compute the seismic inputs to attached equipment are summarized. This case addresses the failure of equipment when the structure remains functional. 23 refs

  10. Seismic behavior of reinforced concrete shear walls

    International Nuclear Information System (INIS)

    Wang, F.; Gantenbein, F.

    1989-01-01

    Reinforced concrete shear walls have an important contribution to building stiffness. So, it is necessary to know their behavior under seismic loads. The ultimate behavior study of shear walls subjected to dynamic loadings includes: - a description of the nonlinear global model based on cyclic static tests, - nonlinear time history calculations for various forcing functions. The comparison of linear and nonlinear results shows important margins related to the ductility when the bandwidth of the forcing function is narrow and centred on the wall natural frequency

  11. Hard wall - soft wall - vorticity scattering in shear flow

    NARCIS (Netherlands)

    Rienstra, S.W.; Singh, D.K.

    2014-01-01

    An analytically exact solution, for the problem of lowMach number incident vorticity scattering at a hard-soft wall transition, is obtained in the form of Fourier integrals by using theWiener-Hopf method. Harmonic vortical perturbations of inviscid linear shear flow are scattered at the wall

  12. Hard wall - soft wall - vorticity scattering in shear flow

    NARCIS (Netherlands)

    Rienstra, S.W.; Singh, D.K.

    2014-01-01

    An analytically exact solution, for the problem of low Mach number incident vorticity scattering at a hard-soft wall transition, is obtained in the form of Fourier integrals by using the Wiener-Hopf method. Harmonic vortical perturbations of inviscid linear shear flow are scattered at the wall

  13. Pressure and wall shear stress in blood hammer - Analytical theory.

    Science.gov (United States)

    Mei, Chiang C; Jing, Haixiao

    2016-10-01

    We describe an analytical theory of blood hammer in a long and stiffened artery due to sudden blockage. Based on the model of a viscous fluid in laminar flow, we derive explicit expressions of oscillatory pressure and wall shear stress. To examine the effects on local plaque formation we also allow the blood vessel radius to be slightly nonuniform. Without resorting to discrete computation, the asymptotic method of multiple scales is utilized to deal with the sharp contrast of time scales. The effects of plaque and blocking time on blood pressure and wall shear stress are studied. The theory is validated by comparison with existing water hammer experiments. Copyright © 2016. Published by Elsevier Inc.

  14. Stent implantation influence wall shear stress evolution

    Science.gov (United States)

    Bernad, S. I.; Totorean, A. F.; Bosioc, A. I.; Petre, I.; Bernad, E. S.

    2016-06-01

    Local hemodynamic factors are known affect the natural history of the restenosis critically after coronary stenting of atherosclerosis. Stent-induced flows disturbance magnitude dependent directly on the strut design. The impact of flow alterations around struts vary as the strut geometrical parameters change. Our results provide data regarding the hemodynamic parameters for the blood flow in both stenosed and stented coronary artery under physiological conditions, namely wall shear stress and pressure drop.

  15. Experimental study of a shear wall with numerous small openings

    International Nuclear Information System (INIS)

    Sotomura, K.; Murazumi, Y.; Yoshizaki, S.; Ezaki, T.

    1981-01-01

    Many small openings for piping and ducts are usually required in the shear walls for PWR nuclear power plant. It is generally believed that such openings oadversely affect the strength and stiffness of shear walls. However, little information is available concerning the behavior of walls with numerous small openings. Therefore, tests using wall specimens and an analysis using an FEM program were carried out to investigate this behavior. Main findings are as follows: 1) The ultimate strength of a shear wall with numerous small openings may be obtained by using the effective area at the critical cross section of the shear wall. 2) Shear walls with openings can be restored to the same shear strength and stiffness as shear walls without openings by diagonal reinforcement. (orig./HP)

  16. Wall Shear Stress, Wall Pressure and Near Wall Velocity Field Relationships in a Whirling Annular Seal

    Science.gov (United States)

    Morrison, Gerald L.; Winslow, Robert B.; Thames, H. Davis, III

    1996-01-01

    The mean and phase averaged pressure and wall shear stress distributions were measured on the stator wall of a 50% eccentric annular seal which was whirling in a circular orbit at the same speed as the shaft rotation. The shear stresses were measured using flush mounted hot-film probes. Four different operating conditions were considered consisting of Reynolds numbers of 12,000 and 24,000 and Taylor numbers of 3,300 and 6,600. At each of the operating conditions the axial distribution (from Z/L = -0.2 to 1.2) of the mean pressure, shear stress magnitude, and shear stress direction on the stator wall were measured. Also measured were the phase averaged pressure and shear stress. These data were combined to calculate the force distributions along the seal length. Integration of the force distributions result in the net forces and moments generated by the pressure and shear stresses. The flow field inside the seal operating at a Reynolds number of 24,000 and a Taylor number of 6,600 has been measured using a 3-D laser Doppler anemometer system. Phase averaged wall pressure and wall shear stress are presented along with phase averaged mean velocity and turbulence kinetic energy distributions located 0.16c from the stator wall where c is the seal clearance. The relationships between the velocity, turbulence, wall pressure and wall shear stress are very complex and do not follow simple bulk flow predictions.

  17. Critical wall shear stress for the EHEDG test method

    DEFF Research Database (Denmark)

    Jensen, Bo Boye Busk; Friis, Alan

    2004-01-01

    In order to simulate the results of practical cleaning tests on closed processing equipment, based on wall shear stress predicted by computational fluid dynamics, a critical wall shear stress is required for that particular cleaning method. This work presents investigations that provide a critical...... wall shear stress of 3 Pa for the standardised EHEDG cleaning test method. The cleaning tests were performed on a test disc placed in a radial flowcell assay. Turbulent flow conditions were generated and the corresponding wall shear stresses were predicted from CFD simulations. Combining wall shear...... stress predictions from a simulation using the low Re k-epsilon and one using the two-layer model of Norris and Reynolds were found to produce reliable predictions compared to empirical solutions for the ideal flow case. The comparison of wall shear stress curves predicted for the real RFC...

  18. Research Status on Bonding Behavior of Prefabricated Concrete Shear Wall

    Science.gov (United States)

    Wang, Donghui; Liu, Xudong; Wang, Sheng; Li, Shanshan

    2018-03-01

    Prefabricated shear wall structure adapts to the development and requirements of China’s residential industrialization. The key to the prefabricated concrete shear wall structure is the connection between the prefabricated members, where the reliability of the connection of the concrete joint is related to the overall performance and seismic effect of the structure. In this paper, the microstructures of the joint surface and shear properties are analysed, and the formula for calculating the shear strength of the joint is obtained.

  19. Wall shear stress fixed points in cardiovascular fluid mechanics.

    Science.gov (United States)

    Arzani, Amirhossein; Shadden, Shawn C

    2018-05-17

    Complex blood flow in large arteries creates rich wall shear stress (WSS) vectorial features. WSS acts as a link between blood flow dynamics and the biology of various cardiovascular diseases. WSS has been of great interest in a wide range of studies and has been the most popular measure to correlate blood flow to cardiovascular disease. Recent studies have emphasized different vectorial features of WSS. However, fixed points in the WSS vector field have not received much attention. A WSS fixed point is a point on the vessel wall where the WSS vector vanishes. In this article, WSS fixed points are classified and the aspects by which they could influence cardiovascular disease are reviewed. First, the connection between WSS fixed points and the flow topology away from the vessel wall is discussed. Second, the potential role of time-averaged WSS fixed points in biochemical mass transport is demonstrated using the recent concept of Lagrangian WSS structures. Finally, simple measures are proposed to quantify the exposure of the endothelial cells to WSS fixed points. Examples from various arterial flow applications are demonstrated. Copyright © 2018 Elsevier Ltd. All rights reserved.

  20. Benchmark study of shear buckling of a cylindrical vessel

    International Nuclear Information System (INIS)

    Dostal, M.; Austin, N.M.; Peano, A.; Combescure, A.; Bastien, R.; Carnoy, E.G.

    1986-01-01

    The possibility of a buckling failure of the primary vessel subjected to seismic excitation has been considered, by all major designers of loop and pool type liquid metal cooled fast breeder reactors. The problem is particularly onerous in this type of reactor due to their large size, coupled with small wall thicknesses. This report details the results of the first phase in a joint European code validation exercise on the static shear buckling behaviour of thin, low aspect ratio stainless steel cylinders. Linear and non-linear finite element analyses were performed by four organizations using three different computer codes, i.e. NNC (UK)-ABAQUS, ISMES (Italy)-ABAQUS, CEA (France)-BILBO/INCA and NOVATOME (France)-NOVNL. The computed results were compared directly with experimental results. It was discovered that refined finite element models were essential if accurate buckling loads were to be calculated. Buckling analyses in 3D were therefore computationally expensive and 2D analyses, where applicable, proved an useful alternative. Traditional linear (Euler) bifurcation analysis seriously over-estimated the buckling loads by around 50 %. Extrapolation techniques can however be used to reduce this discrepancy. Elasto-plastic bifurcation analysis predicted conservative buckling loads close to the experimental value. Non-linear, large displacement analyses were performed on the vessel. The effect of geometrical imperfections in the vessel was considered. These analyses all over-estimated the experimental buckling load by 10 %-25 % and appeared to be largely insensitive to the initial imperfection size. Each of the codes appeared to predict reasonably well the final buckled geometry although the analytical load-deflection estimate did not agree exactly with the experiment

  1. Failure modes of low-rise shear walls

    International Nuclear Information System (INIS)

    Farrar, C.R.; Reed, J.W.; Salmon, M.W.

    1993-01-01

    A summary of available data concerning the structural response of low-rise shear walls is presented. These data will be used to address two failure modes associated with shear wall structures. First, the data concerning the seismic capacity of the shear walls are examined, with emphasis on excessive deformations that can cause equipment failure. Second, the data concerning the dynamic properties of shear walls (stiffness and damping) that are necessary for computing the seismic inputs to attached equipment are summarized. This case addresses the failure of equipment when the structure remains functional

  2. Research Advances on Fabricated Shear Wall System

    Science.gov (United States)

    Liu, Xudong; Wang, Donghui; Wang, Sheng; Zhai, Yu

    2018-03-01

    With the rapid development of the construction industry, building energy consumption has been increasing, has become a problem that can not be ignored. It is imperative to develop energy-saving buildings. A new type of prefabricated shear wall is assembled and partially assembled by prefabricated parts, and some concrete is spliced together. The new structure has good integrity, seismic resistance and excellent energy saving and environmental protection performance. It reduces building energy consumption to a great extent. Therefore, the design method, manufacturing process, site assembly process and key technical problems of the system are discussed. For the construction industry gradually entered the energy conservation, environmental protection, safety and durability of sustainable development laid the foundation.

  3. Thinner regions of intracranial aneurysm wall correlate with regions of higher wall shear stress: a 7.0 tesla MRI

    Science.gov (United States)

    Blankena, Roos; Kleinloog, Rachel; Verweij, Bon H.; van Ooij, Pim; ten Haken, Bennie; Luijten, Peter R.; Rinkel, Gabriel J.E.; Zwanenburg, Jaco J.M.

    2016-01-01

    Purpose To develop a method for semi-quantitative wall thickness assessment on in vivo 7.0 tesla (7T) MRI images of intracranial aneurysms for studying the relation between apparent aneurysm wall thickness and wall shear stress. Materials and Methods Wall thickness was analyzed in 11 unruptured aneurysms in 9 patients, who underwent 7T MRI with a TSE based vessel wall sequence (0.8 mm isotropic resolution). A custom analysis program determined the in vivo aneurysm wall intensities, which were normalized to signal of nearby brain tissue and were used as measure for apparent wall thickness (AWT). Spatial wall thickness variation was determined as the interquartile range in AWT (the middle 50% of the AWT range). Wall shear stress was determined using phase contrast MRI (0.5 mm isotropic resolution). We performed visual and statistical comparisons (Pearson’s correlation) to study the relation between wall thickness and wall shear stress. Results 3D colored AWT maps of the aneurysms showed spatial AWT variation, which ranged from 0.07 to 0.53, with a mean variation of 0.22 (a variation of 1.0 roughly means a wall thickness variation of one voxel (0.8mm)). In all aneurysms, AWT was inversely related to WSS (mean correlation coefficient −0.35, P<0.05). Conclusions A method was developed to measure the wall thickness semi-quantitatively, using 7T MRI. An inverse correlation between wall shear stress and AWT was determined. In future studies, this non-invasive method can be used to assess spatial wall thickness variation in relation to pathophysiologic processes such as aneurysm growth and –rupture. PMID:26892986

  4. Evaluation of composite shear walls behavior (parametric study

    Directory of Open Access Journals (Sweden)

    Ali Nikkhoo

    2017-11-01

    Full Text Available Composite shear walls which are made of a layer of steel plate with a concrete cover in one or both sides of the steel plate, are counted as the third generation of the shear walls. Nowadays, composite shear walls are widely utilized in building new resisting structures as well as rehabilitating of the existing structures in earthquake-prone countries. Despite of its advantages, use of the composite shear walls is not yet prevalent as it demands more detailed appropriate investigation. Serving higher strength, flexibility and better energy absorption, while being more economical are the main advantages of this system which has paved its path to be used in high-rise buildings, structural retrofit and reservoir tanks. In this research, channel shear connectors are utilized to connect the concrete cover to the steel plate. As a key parameter, variation in the distance of shear connectors and their arrangement on the behavior of composite shear walls has been scrutinized. In addition, the shear stiffness, flexibility, out of plane displacement and the energy absorption of the structural system has been explored. For this purpose, several structural models with different shear distances and arrangements have been investigated. The obtained results reveal that with increase in shear connectors’ distance, the wall stiffness would reduce while its lateral displacement increases up to eighty percent While the out of plane displacement of the steel plate will reduce up to three times.

  5. Role of arginase in vessel wall remodeling

    Directory of Open Access Journals (Sweden)

    William eDurante

    2013-05-01

    Full Text Available Arginase metabolizes the semi-essential amino acid L-arginine to L-ornithine and urea. There are two distinct isoforms of arginase, arginase I and II, which are encoded by separate genes and display differences in tissue distribution, subcellular localization, and molecular regulation. Blood vessels express both arginase I and II but their distribution appears to be cell-, vessel-, and species-specific. Both isoforms of arginase are induced by numerous pathologic stimuli and contribute to vascular cell dysfunction and vessel wall remodeling in several diseases. Clinical and experimental studies have documented increases in the expression and/or activity of arginase I or II in blood vessels following arterial injury and in pulmonary and arterial hypertension, aging, and atherosclerosis. Significantly, pharmacological inhibition or genetic ablation of arginase in animals ameliorates abnormalities in vascular cells and normalizes blood vessel architecture and function in all of these pathological states. The detrimental effect of arginase in vascular remodeling is attributable to its ability to stimulate vascular smooth muscle cell and endothelial cell proliferation, and collagen deposition by promoting the synthesis of polyamines and L-proline, respectively. In addition, arginase adversely impacts arterial remodeling by directing macrophages towards an inflammatory phenotype. Moreover, the proliferative, fibrotic, and inflammatory actions of arginase in the vasculature are further amplified by its capacity to inhibit nitric oxide synthesis by competing with nitric oxide synthase for substrate, L-arginine. Pharmacologic or molecular approaches targeting specific isoforms of arginase represent a promising strategy in treating obstructive fibroproliferative vascular disease.

  6. Wall morphology, blood flow and wall shear stress: MR findings in patients with peripheral artery disease

    Energy Technology Data Exchange (ETDEWEB)

    Galizia, Mauricio S.; Barker, Alex; Collins, Jeremy; Carr, James [Northwestern University, Department of Radiology, Feinberg School of Medicine, Chicago, IL (United States); Liao, Yihua [Northwestern University' s Feinberg School of Medicine, Department of Preventive Medicine, Chicago, IL (United States); McDermott, Mary M. [Northwestern University' s Feinberg School of Medicine, Department of Preventive Medicine, Chicago, IL (United States); Northwestern University' s Feinberg School of Medicine, Department of Medicine, Chicago, IL (United States); Markl, Michael [Northwestern University, Department of Radiology, Feinberg School of Medicine, Chicago, IL (United States); Northwestern University, Department Biomedical Engineering, McCormick School of Engineering, Chicago, IL (United States)

    2014-04-15

    To investigate the influence of atherosclerotic plaques on femoral haemodynamics assessed by two-dimensional (2D) phase-contrast (PC) magnetic resonance imaging (MRI) with three-directional velocity encoding. During 1 year, patients with peripheral artery disease and an ankle brachial index <1.00 were enrolled. After institutional review board approval and written informed consent, 44 patients (age, 70 ± 12 years) underwent common femoral artery MRI. Patients with contra-indications for MRI were excluded. Sequences included 2D time-of-flight, proton-density, T1-weighted and T2-weighted MRI. Electrocardiogram (ECG)-gated 2D PC-MRI with 3D velocity encoding was acquired. A radiologist classified images in five categories. Blood flow, velocity and wall shear stress (WSS) along the vessel circumference were quantified from the PC-MRI data. The acquired images were of good quality for interpretation. There were no image quality problems related to poor ECG-gating or slice positioning. Velocities, oscillatory shear stress and total flow were similar between patients with normal arteries and wall thickening/plaque. Patients with plaques demonstrated regionally increased peak systolic WSS and enhanced WSS eccentricity. Combined multi-contrast morphological imaging of the peripheral arterial wall with PC-MRI with three-directional velocity encoding is a feasible technique. Further study is needed to determine whether flow is an appropriate marker for altered endothelial cell function, vascular remodelling and plaque progression. (orig.)

  7. Seismic behavior of semi-supported steel shear walls

    DEFF Research Database (Denmark)

    Jahanpour, A.; Jönsson, J.; Moharrami, H.

    2012-01-01

    During the recent past decade semi-supported steel shear walls (SSSW) have been introduced as an alternative to the traditional type of steel plate shear walls. In this system the shear wall does not connect directly to the main columns of the building frame; instead it is connected to a pair...... of secondary columns that do not carry vertical gravity loads. In this paper, the interaction between the wall plate and the surrounding frame is investigated experimentally for typical SSSW systems in which the wall-frame has a bending-dominant behavior. Based on the possible storey failure mechanisms...... a simple method is proposed for design of the floor beams. A quasi static cyclic experimental study has been performed in order to investigate the collapse behavior of the wall-plate and surrounding frame. Furthermore the test setup has been developed in order to facilitate standardized cyclic tests...

  8. An experimental investigation for external RC shear wall applications

    Science.gov (United States)

    Kaltakci, M. Y.; Ozturk, M.; Arslan, M. H.

    2010-09-01

    The strength and rigidity of most reinforced concrete (RC) buildings in Turkey, which are frequently hit by destructive earthquakes, is not at a sufficient level. Therefore, the result of earthquakes is a significant loss of life and property. The strengthening method most commonly preferred for these type of RC buildings is the application of RC infilled walls (shear walls) in the frame openings of the building. However, since the whole building has to be emptied and additional heavy costs arise during this type of strengthening, users prefer not to strengthen their buildings despite the heavy risk they are exposed to. Therefore, it is necessary to develop easier-to-apply and more effective methods for the rapid strengthening of housing and the heavily-used public buildings which cannot be emptied during the strengthening process (such as hospitals and schools). This study empirically analyses the different methods of a new system which can meet this need. In this new system, named "external shear wall application", RC shear walls are applied on the external surface of the building, along the frame plane rather than in the building. To this end, 7 test samples in 1/2 and 1/3 geometrical scale were designed to analyse the efficiency of the strengthening technique where the shear wall leans on the frame from outside of the building (external shear wall application) and of the strengthening technique where a specific space is left between the frame and the external shear wall by using a coupling beam to connect elements (application of external shear wall with coupling beam). Test results showed that the maximum lateral load capacity, initial rigidity and energy dissipation behaviours of the samples strengthened with external shear wall were much better than those of the bare frames.

  9. An experimental investigation for external RC shear wall applications

    Directory of Open Access Journals (Sweden)

    M. Y. Kaltakci

    2010-09-01

    Full Text Available The strength and rigidity of most reinforced concrete (RC buildings in Turkey, which are frequently hit by destructive earthquakes, is not at a sufficient level. Therefore, the result of earthquakes is a significant loss of life and property. The strengthening method most commonly preferred for these type of RC buildings is the application of RC infilled walls (shear walls in the frame openings of the building. However, since the whole building has to be emptied and additional heavy costs arise during this type of strengthening, users prefer not to strengthen their buildings despite the heavy risk they are exposed to. Therefore, it is necessary to develop easier-to-apply and more effective methods for the rapid strengthening of housing and the heavily-used public buildings which cannot be emptied during the strengthening process (such as hospitals and schools. This study empirically analyses the different methods of a new system which can meet this need. In this new system, named "external shear wall application", RC shear walls are applied on the external surface of the building, along the frame plane rather than in the building. To this end, 7 test samples in 1/2 and 1/3 geometrical scale were designed to analyse the efficiency of the strengthening technique where the shear wall leans on the frame from outside of the building (external shear wall application and of the strengthening technique where a specific space is left between the frame and the external shear wall by using a coupling beam to connect elements (application of external shear wall with coupling beam. Test results showed that the maximum lateral load capacity, initial rigidity and energy dissipation behaviours of the samples strengthened with external shear wall were much better than those of the bare frames.

  10. Effects of opening in shear walls of 30- storey building

    Directory of Open Access Journals (Sweden)

    Ruchi Sharma

    2015-03-01

    Full Text Available Tall towers and multi-storey buildings have fascinated mankind from the beginning of civilization, their construction being initially for defense and subsequently for ecclesiastical purposes. These tall buildings because of its height, is affected by lateral forces due to wind or earthquake actions tends to snap the building in shear and push it over in bending. In general, the rigidity (i.e. Resistance to lateral deflection and stability (i.e. Resistance to overturning moments requirement become more important. Shear walls (Structural walls contribute significant lateral stiffness, strength, and overall ductility and energy dissipation capacity. In many structural walls a regular pattern of openings has to be provided due to various functional requirements such as to accommodate doors, windows and service ducts. Such type of openings reduces the stiffness of the shear wall to some extent depending on the shape and size of the opening. In the present parametric study, efforts are made to investigate and critically assess the effects of various size of openings in shear walls on the responses and behaviors of multi-storey buildings. The 30 storey Prototype buildings with different types of openings in shear wall with and without incorporating the volume of shear wall reduced in the boundary elements are analyzed using software E-TABS using Response spectrum method (1893(Part-1-2002 and Time history method.

  11. Finite element analyses for Seismic Shear Wall International Standard Problem

    International Nuclear Information System (INIS)

    Park, Y.; Hofmayer, C.; Chokshi, N.

    1997-01-01

    In the seismic design of shear wall structures, e.g., nuclear reactor buildings, a linear FEM analysis is frequently used to quantify the stresses under the design loading condition. The final design decisions, however, are still based on empirical design rules established over decades from accumulated laboratory test data. This paper presents an overview of the state-of-the-art on the application of nonlinear FEM analysis to reinforced concrete (RC) shear wall structures under severe earthquake loadings based on the findings obtained during the Seismic Shear Wall International Standard Problem (SSWISP) Workshop in 1996. Also, BNL's analysis results of the International Standard Problem (ISP) shear walls under monotonic static, cyclic static and dynamic loading conditions are described

  12. Experimental study on concrete shear wall behavior under seismic loading

    International Nuclear Information System (INIS)

    Gantenbein, F.; Queval, J.C.; Epstein, A.; Dalbera, J.

    1991-01-01

    An experimental program has been undertaken on the dynamic behavior of shear walls with and without openings. The experimental set-up, the test program and the main results will be detailed in the paper

  13. Inplane shear capacity of reinforced composite masonry block walls

    International Nuclear Information System (INIS)

    White, W.H.; Tseng, W.S.

    1981-01-01

    The objective of this paper is to describe a test program performed to determine the inplane shear capacity, stiffness and ductility of composite masonry walls subjected to earthquake type loadings. Specimens were simultaneously subjected to a range of compressive loads to simulate dead load; and inplane shear loads with full load reversal to simulate the earthquake cycling load. The influence of horizontal and vertical reinforcing steel percentages on the inplane shear capacity, stiffness and ductility was also investigated. (orig./HP)

  14. Triglyceride glucose index and common carotid wall shear stress.

    Science.gov (United States)

    Tripolino, Cesare; Irace, Concetta; Scavelli, Faustina B; de Franceschi, Maria S; Esposito, Teresa; Carallo, Claudio; Gnasso, Agostino

    2014-02-01

    Alterations in wall shear stress contribute to both clinical and subclinical atherosclerosis. Several conditions such as hypertension, diabetes, and obesity can impair shear stress, but the role of insulin resistance has never been investigated. The present study was designed to investigate whether insulin resistance assessed by TyG Index associates with wall shear stress in the common carotid artery. One hundred six individuals were enrolled. Blood pressure, lipids, glucose, and cigarette smoking were evaluated. TyG Index was calculated as log[fasting triglycerides × fasting glucose / 2]. Subjects underwent blood viscosity measurement and echo-Doppler evaluation of carotid arteries to calculate wall shear stress. The association between TyG Index and carotid wall shear stress was assessed by simple and multiple regression analyses. TyG Index was significantly and inversely associated with carotid wall shear stress both in simple (r = -0.44, P glucose greater than 100 mg/dL, and triglycerides greater than 150 mg/dL. The present findings suggest that increasing insulin resistance, as assessed by TyG Index, associates with atherosclerosis-prone shear stress reduction in the common carotid artery.

  15. In vivo wall shear measurements within the developing zebrafish heart.

    Directory of Open Access Journals (Sweden)

    R Aidan Jamison

    Full Text Available Physical forces can influence the embryonic development of many tissues. Within the cardiovascular system shear forces resulting from blood flow are known to be one of the regulatory signals that shape the developing heart. A key challenge in investigating the role of shear forces in cardiac development is the ability to obtain shear force measurements in vivo. Utilising the zebrafish model system we have developed a methodology that allows the shear force within the developing embryonic heart to be determined. Accurate wall shear measurement requires two essential pieces of information; high-resolution velocity measurements near the heart wall and the location and orientation of the heart wall itself. We have applied high-speed brightfield imaging to capture time-lapse series of blood flow within the beating heart between 3 and 6 days post-fertilization. Cardiac-phase filtering is applied to these time-lapse images to remove the heart wall and other slow moving structures leaving only the red blood cell movement. Using particle image velocimetry to calculate the velocity of red blood cells in different regions within the heart, and using the signal-to-noise ratio of the cardiac-phase filtered images to determine the boundary of blood flow, and therefore the position of the heart wall, we have been able to generate the necessary information to measure wall shear in vivo. We describe the methodology required to measure shear in vivo and the application of this technique to the developing zebrafish heart. We identify a reduction in shear at the ventricular-bulbar valve between 3 and 6 days post-fertilization and demonstrate that the shear environment of the ventricle during systole is constantly developing towards a more uniform level.

  16. In vivo wall shear measurements within the developing zebrafish heart.

    Science.gov (United States)

    Jamison, R Aidan; Samarage, Chaminda R; Bryson-Richardson, Robert J; Fouras, Andreas

    2013-01-01

    Physical forces can influence the embryonic development of many tissues. Within the cardiovascular system shear forces resulting from blood flow are known to be one of the regulatory signals that shape the developing heart. A key challenge in investigating the role of shear forces in cardiac development is the ability to obtain shear force measurements in vivo. Utilising the zebrafish model system we have developed a methodology that allows the shear force within the developing embryonic heart to be determined. Accurate wall shear measurement requires two essential pieces of information; high-resolution velocity measurements near the heart wall and the location and orientation of the heart wall itself. We have applied high-speed brightfield imaging to capture time-lapse series of blood flow within the beating heart between 3 and 6 days post-fertilization. Cardiac-phase filtering is applied to these time-lapse images to remove the heart wall and other slow moving structures leaving only the red blood cell movement. Using particle image velocimetry to calculate the velocity of red blood cells in different regions within the heart, and using the signal-to-noise ratio of the cardiac-phase filtered images to determine the boundary of blood flow, and therefore the position of the heart wall, we have been able to generate the necessary information to measure wall shear in vivo. We describe the methodology required to measure shear in vivo and the application of this technique to the developing zebrafish heart. We identify a reduction in shear at the ventricular-bulbar valve between 3 and 6 days post-fertilization and demonstrate that the shear environment of the ventricle during systole is constantly developing towards a more uniform level.

  17. Optimization of multiplane ?PIV for wall shear stress and wall topography characterization

    NARCIS (Netherlands)

    Rossi, M.; Lindken, R.; Westerweel, J.

    2009-01-01

    Multiplane ?PIV can be utilized to determine the wall shear stress and wall topology from the measured flow over a structured surface. A theoretical model was developed to predict the measurement error for the surface topography and shear stress, based on a theoretical analysis of the precision in

  18. Wall shear stress hot film sensor for use in gases

    International Nuclear Information System (INIS)

    Osorio, O D; Silin, N

    2011-01-01

    The purpose of this work is to present the construction and characterization of a wall shear stress hot film sensor for use in gases made with MEMS technology. For this purpose, several associated devices were used, including a constant temperature feedback bridge and a shear stress calibration device that allows the sensor performance evaluation. The sensor design adopted here is simple, economical and is manufactured on a flexible substrate allowing its application to curved surfaces. Stationary and transient wall shear stress tests were carried on by means of the calibration device, determining its performance for different conditions.

  19. Intracranial vessel wall imaging at 7.0 tesla MRI

    NARCIS (Netherlands)

    van der Kolk, A.G.

    2014-01-01

    Intracranial atherosclerosis is one of the main causes of ischemic stroke. Current conventional imaging techniques assessing intracranial arterial disease in vivo only visualize the vessel wall lumen instead of the pathological vessel wall itself. Therefore, not much is known about the imaging

  20. Determination of seismic performance factors for CLT shear wall systems

    Science.gov (United States)

    M. Omar Amini; John W. van de Lindt; Douglas Rammer; Shiling Pei; Philip Line; Marjan Popovski

    2016-01-01

    This paper presents selected results of connector testing and wall testing which were part of a Forest Products Lab-funded project undertaken at Colorado State University in an effort to determine seismic performance factors for cross laminated timber (CLT) shear walls in the United States. Archetype development, which is required as part of the process, is also...

  1. Degree of coupling in high-rise mixed shear walls structures

    Indian Academy of Sciences (India)

    A simple method of analysis is presented to determine the influence of single shear walls (SSW) on the degree of coupling DoC and on the peak shear demand PSD for beams of coupled shear walls (CSW) in mixed shear wall structures (MSW). Non-coupled lateral load resisting structures such as singular planar walls and ...

  2. Determination of wall shear stress from mean velocity and Reynolds shear stress profiles

    Science.gov (United States)

    Volino, Ralph J.; Schultz, Michael P.

    2018-03-01

    An analytical method is presented for determining the Reynolds shear stress profile in steady, two-dimensional wall-bounded flows using the mean streamwise velocity. The method is then utilized with experimental data to determine the local wall shear stress. The procedure is applicable to flows on smooth and rough surfaces with arbitrary pressure gradients. It is based on the streamwise component of the boundary layer momentum equation, which is transformed into inner coordinates. The method requires velocity profiles from at least two streamwise locations, but the formulation of the momentum equation reduces the dependence on streamwise gradients. The method is verified through application to laminar flow solutions and turbulent DNS results from both zero and nonzero pressure gradient boundary layers. With strong favorable pressure gradients, the method is shown to be accurate for finding the wall shear stress in cases where the Clauser fit technique loses accuracy. The method is then applied to experimental data from the literature from zero pressure gradient studies on smooth and rough walls, and favorable and adverse pressure gradient cases on smooth walls. Data from very near the wall are not required for determination of the wall shear stress. Wall friction velocities obtained using the present method agree with those determined in the original studies, typically to within 2%.

  3. Intracranial Vascular Disease Evaluation With Combined Vessel Wall Imaging And Patient Specific Hemodynamics

    Science.gov (United States)

    Samson, Kurt; Mossa-Basha, Mahmud; Yuan, Chun; Canton, Maria De Gador; Aliseda, Alberto

    2017-11-01

    Intracranial vascular pathologies are evaluated with angiography, conventional digital subtraction angiography or non-invasive (MRI, CT). Current techniques present limitations on the resolution with which the vessel wall characteristics can be measured, presenting a major challenge to differential diagnostic of cerebral vasculopathies. A new combined approach is presented that incorporates patient-specific image-based CFD models with intracranial vessel-wall MRI (VWMRI). Comparisons of the VWMRI measurements, evaluated for the presence of wall enhancement and thin-walled regions, against CFD metrics such as wall shear stress (WSS), and oscillatory shear index (OSI) are used to understand how the new imaging technique developed can predict the influence of hemodynamics on the deterioration of the aneurysmal wall, leading to rupture. Additionally, histology of each resected aneurysm, evaluated for inflammatory infiltration and wall thickness features, is used to validate the analysis from VWMRI and CFD. This data presents a solid foundation on which to build a new framework for combined VWMRI-CFD to predict unstable wall changes in unruptured intracranial aneurysms, and support clinical monitoring and intervention decisions.

  4. Shear strength of end slabs of prestressed concrete reactor vessels

    International Nuclear Information System (INIS)

    Cheung, K.C.; Gotschall, H.L.; Liu, T.C.

    1975-01-01

    Prestressed concrete reactor vessels (PCRV's) have been adopted for primary containments in most large high-temperature gas-cooled reactor installations. The most common configuration for PCRVs is a right-vertical cylinder with thick end slabs. In order to assess the integrity of a PCRV it is necessary to predict the ultimate strength of the end slabs. The complexity of the basic mechanism of shear failure in the PCRV end slabs has thus far prohibited the development of a completely analytical solution. However, many experimental investigations of PCRV end slabs have been conducted over the past decade. This information makes it possible to establish empirical formulae for the ultimate strength of PCRV end slabs. The basis and development of an empirical shear-flexure interaction expression is presented. (Auth.)

  5. The influence of geometric factors on the wall shear stress distribution in realistic human coronary arteries

    OpenAIRE

    Santos, Jorge André Piedade Pinhal dos

    2009-01-01

    Dissertação apresentada na Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa para a obtenção do grau de Mestre em Engenharia Biomédica. A presente dissertação foi desenvolvida no Erasmus Medical Center em Roterdão, Holanda Background: Atherosclerosis is the main cause of death in the Western society. It is a geometrically focal disease, affecting preferentially vessel areas of low wall shear stress (SS), which induces the expression of atherogenic genes. To predict wall ...

  6. Damage Detection of Reinforced Concrete Shear Walls Using Mathematical Transformations

    Directory of Open Access Journals (Sweden)

    Hosein Naderpour

    2017-02-01

    Full Text Available Structural health monitoring is a procedure to provide accurate and immediate information on the condition and efficiency of structures. There is variety of damage factors and the unpredictability of future damage, is a necessity for the use of structural health monitoring. Structural health monitoring and damage detection in early stages is one of the most interesting topics that had been paid attention because the majority of damages can be repaired and reformed by initial evaluation ,thus the spread of damage to the structures, building collapse and rising of costs can be avoided .Detection of concrete shear wall damages are designed to withstand the lateral load on the structure is critical .Because failures and  malfunctions of shear walls can lead to serious damage or even progressive dilapidation of concrete structures .Change in stiffness and frequency can clearly show the damage occurrence. Mathematical transformation is also a tool to detect damage. In this article, with non- linear time history analysis, the finite element model of structures with concrete shear walls subject to four earthquakes have extracted and using Fourier and wavelet transform, the presence of shear walls is detected at the time of damage.

  7. Dynamical analysis of electrochemical wall shear rate measurements

    NARCIS (Netherlands)

    Steenhoven, van A.A.; Beucken, van den F.J.H.M.

    1991-01-01

    The performance of a circular electrochemical wall shear rate probe under unsteady flow conditions is analysed through a combined ezxperimental, numerical and analytical approach. The experiments are performed with a ferri- and ferrocyanide redox couple and compared to finite element analysis of the

  8. Contrast-enhanced micro-CT imaging in murine carotid arteries: A new protocol for computing wall shear stress

    NARCIS (Netherlands)

    Xing, R. (Ruoyu); Wilde, D. (David); McCann, G. (Gayle); Y. Ridwan (Yanto); J.T.C. Schrauwen (Jelle); A.F.W. Steen (Antonius F.W.); F.J.H. Gijsen (Frank); Heiden, K. (Kim)

    2016-01-01

    textabstractBackground: Wall shear stress (WSS) is involved in the pathophysiology of atherosclerosis. The correlation between WSS and atherosclerosis can be investigated over time using a WSS-manipulated atherosclerotic mouse model. To determine WSS in vivo, detailed 3D geometry of the vessel

  9. Seismic Behaviour of Composite Steel Fibre Reinforced Concrete Shear Walls

    Science.gov (United States)

    Boita, Ioana-Emanuela; Dan, Daniel; Stoian, Valeriu

    2017-10-01

    In this paper is presented an experimental study conducted at the “Politehnica” University of Timisoara, Romania. This study provides results from a comprehensive experimental investigation on the behaviour of composite steel fibre reinforced concrete shear walls (CSFRCW) with partially or totally encased profiles. Two experimental composite steel fibre reinforced concrete walls (CSFRCW) and, as a reference specimen, a typical reinforced concrete shear wall (RCW), (without structural reinforcement), were fabricated and tested under constant vertical load and quasi-static reversed cyclic lateral loads, in displacement control. The tests were performed until failure. The tested specimens were designed as 1:3 scale steel-concrete composite elements, representing a three storeys and one bay element from the base of a lateral resisting system made by shear walls. Configuration/arrangement of steel profiles in cross section were varied within the specimens. The main objective of this research consisted in identifying innovative solutions for composite steel-concrete shear walls with enhanced performance, as steel fibre reinforced concrete which was used in order to replace traditional reinforced concrete. A first conclusion was that replacing traditional reinforcement with steel fibre changes the failure mode of the elements, as from a flexural mode, in case of element RCW, to a shear failure mode for CSFRCW. The maximum lateral force had almost similar values but test results indicated an improvement in cracking response, and a decrease in ductility. The addition of steel fibres in the concrete mixture can lead to an increase of the initial cracking force, and can change the sudden opening of a crack in a more stable process.

  10. Gas leakage rate through reinforced concrete shear walls: Numerical study

    International Nuclear Information System (INIS)

    Wang Ting; Hutchinson, Tara C.

    2005-01-01

    Unlined reinforced concrete shear walls are often used as 'tertiary boundaries' in the United States Department of Energy (DOE) to house dangerous gases. An unanticipated event, such as an earthquake, may cause gases stored inside the walls to disperse into the environment resulting in excess pollution. To address this concern, in this paper, a methodology to numerically predict the gas leakage rate through these shear walls under lateral loading conditions is proposed. This methodology involves finite element and flow rate analysis. Strain distributions are obtained from the finite element analysis, and then used to simulate the crack characteristics on the concrete specimen. The flow rate through the damaged concrete specimen is then estimated using flow rate formulas available from the literature. Results from an experimental specimen are used to evaluate the methodology, and particularly its robustness in the flow rate estimation

  11. Behaviour of Masonry Walls under Horizontal Shear in Mining Areas

    Science.gov (United States)

    Kadela, Marta; Bartoszek, Marek; Fedorowicz, Jan

    2017-12-01

    The paper discusses behaviour of masonry walls constructed with small-sized elements under the effects of mining activity. It presents some mechanisms of damage occurring in such structures, its forms in real life and the behaviour of large fragments of masonry walls subjected to specific loads in FEM computational models. It offers a constitutive material model, which enables numerical analyses and monitoring of the behaviour of numerical models as regards elastic-plastic performance of the material, with consideration of its degradation. Results from the numerical analyses are discussed for isolated fragments of the wall subjected to horizontal shear, with consideration of degradation, impact of imposed vertical load as well as the effect of weakening of the wall, which was achieved by introducing openings in it, on the performance and deformation of the wall.

  12. Heavy wall pressure vessels for energy systems

    International Nuclear Information System (INIS)

    Canonico, D.A.

    Modifications of steels currently accepted in the Code appear to provide improved mechanical properties. These steels may permit the fabrication of larger diameter vessels with thinner section sizes and improved reliability and integrity. Adapting current specifications should expedite Code approval. Finally the challenge of improving welding procedures and adapting processes for field applications will result in higher quality weldments

  13. Evaluation of seismic shear capacity of prestressed concrete containment vessels with fiber reinforcement

    Energy Technology Data Exchange (ETDEWEB)

    Choun, Young Sun; Park, Jun Hee [Integrated Safety Assessment Division, Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    Fibers have been used in cement mixture to improve its toughness, ductility, and tensile strength, and to enhance the cracking and deformation characteristics of concrete structural members. The addition of fibers into conventional reinforced concrete can enhance the structural and functional performances of safety-related concrete structures in nuclear power plants. The effects of steel and polyamide fibers on the shear resisting capacity of a prestressed concrete containment vessel (PCCV) were investigated in this study. For a comparative evaluation between the shear performances of structural walls constructed with conventional concrete, steel fiber reinforced concrete, and polyamide fiber reinforced concrete, cyclic tests for wall specimens were conducted and hysteretic models were derived. The shear resisting capacity of a PCCV constructed with fiber reinforced concrete can be improved considerably. When steel fiber reinforced concrete contains hooked steel fibers in a volume fraction of 1.0%, the maximum lateral displacement of a PCCV can be improved by > 50%, in comparison with that of a conventional PCCV. When polyamide fiber reinforced concrete contains polyamide fibers in a volume fraction of 1.5%, the maximum lateral displacement of a PCCV can be enhanced by ∼40%. In particular, the energy dissipation capacity in a fiber reinforced PCCV can be enhanced by > 200%. The addition of fibers into conventional concrete increases the ductility and energy dissipation of wall structures significantly. Fibers can be effectively used to improve the structural performance of a PCCV subjected to strong ground motions. Steel fibers are more effective in enhancing the shear performance of a PCCV than polyamide fibers.

  14. Evaluation of seismic shear capacity of prestressed concrete containment vessels with fiber reinforcement

    International Nuclear Information System (INIS)

    Choun, Young Sun; Park, Jun Hee

    2015-01-01

    Fibers have been used in cement mixture to improve its toughness, ductility, and tensile strength, and to enhance the cracking and deformation characteristics of concrete structural members. The addition of fibers into conventional reinforced concrete can enhance the structural and functional performances of safety-related concrete structures in nuclear power plants. The effects of steel and polyamide fibers on the shear resisting capacity of a prestressed concrete containment vessel (PCCV) were investigated in this study. For a comparative evaluation between the shear performances of structural walls constructed with conventional concrete, steel fiber reinforced concrete, and polyamide fiber reinforced concrete, cyclic tests for wall specimens were conducted and hysteretic models were derived. The shear resisting capacity of a PCCV constructed with fiber reinforced concrete can be improved considerably. When steel fiber reinforced concrete contains hooked steel fibers in a volume fraction of 1.0%, the maximum lateral displacement of a PCCV can be improved by > 50%, in comparison with that of a conventional PCCV. When polyamide fiber reinforced concrete contains polyamide fibers in a volume fraction of 1.5%, the maximum lateral displacement of a PCCV can be enhanced by ∼40%. In particular, the energy dissipation capacity in a fiber reinforced PCCV can be enhanced by > 200%. The addition of fibers into conventional concrete increases the ductility and energy dissipation of wall structures significantly. Fibers can be effectively used to improve the structural performance of a PCCV subjected to strong ground motions. Steel fibers are more effective in enhancing the shear performance of a PCCV than polyamide fibers

  15. Dynamic behavior and functional integrity tests on RC shear walls

    International Nuclear Information System (INIS)

    Akino, Kinji; Nasuda, Toshiaki; Shibata, Akenori.

    1991-01-01

    A project consisting of seven subprojects has been conducted to study the dynamic behavior and functional integrity of reinforced concrete (RC) shear walls in reactor buildings. The objective of this project is to obtain the data to improve and prepare the seismic analysis code regarding the nonlinear structural behavior and integrity of reactor buildings during and after earthquakes. The project started in April, 1986, and will end in March, 1994. Seven subprojects are strain rate test, damping characteristic test, ultimate state response test and the verification test for the test of restoring force characteristics regarding dynamic restoring force characteristics and damping performance; the restoring force characteristic test on the shear walls with openings; and pull-out strength test and the test on air leakage through concrete cracks regarding the functional integrity. The objectives of respective subprojects, the test models and the interim results are reported. Three subprojects have been completed by March, 1990. The results of these projects will be used for the overall evaluation. The strain rate test showed that the ultimate strength of shear walls increased with strain rate. A formula for estimating air flow through the cracks in walls was given by the leakage test. (K.I.)

  16. Model tests on dynamic performance of RC shear walls

    International Nuclear Information System (INIS)

    Nagashima, Toshio; Shibata, Akenori; Inoue, Norio; Muroi, Kazuo.

    1991-01-01

    For the inelastic dynamic response analysis of a reactor building subjected to earthquakes, it is essentially important to properly evaluate its restoring force characteristics under dynamic loading condition and its damping performance. Reinforced concrete shear walls are the main structural members of a reactor building, and dominate its seismic behavior. In order to obtain the basic information on the dynamic restoring force characteristics and damping performance of shear walls, the dynamic test using a large shaking table, static displacement control test and the pseudo-dynamic test on the models of a shear wall were conducted. In the dynamic test, four specimens were tested on a large shaking table. In the static test, four specimens were tested, and in the pseudo-dynamic test, three specimens were tested. These tests are outlined. The results of these tests were compared, placing emphasis on the restoring force characteristics and damping performance of the RC wall models. The strength was higher in the dynamic test models than in the static test models mainly due to the effect of loading rate. (K.I.)

  17. Test and Analysis of a New Ductile Shear Connection Design for RC Shear Walls

    DEFF Research Database (Denmark)

    Sørensen, Jesper Harrild; Hoang, Linh Cao; Olesen, John Forbes

    2017-01-01

    -bar loops. Contrary to the classical shear connections, the planes of the U-bar loops are here parallel to the plane of the wall elements. This feature enables a construction-friendly installation of the elements without the risk of rebars clashing. The core of mortar inside each U-bar loop is reinforced...

  18. Assessment of turbulent flow effects on the vessel wall using four-dimensional flow MRI.

    Science.gov (United States)

    Ziegler, Magnus; Lantz, Jonas; Ebbers, Tino; Dyverfeldt, Petter

    2017-06-01

    To explore the use of MR-estimated turbulence quantities for the assessment of turbulent flow effects on the vessel wall. Numerical velocity data for two patient-derived models was obtained using computational fluid dynamics (CFD) for two physiological flow rates. The four-dimensional (4D) Flow MRI measurements were simulated at three different spatial resolutions and used to investigate the estimation of turbulent wall shear stress (tWSS) using the intravoxel standard deviation (IVSD) of velocity and turbulent kinetic energy (TKE) estimated near the vessel wall. Accurate estimation of tWSS using the IVSD is limited by the spatial resolution achievable with 4D Flow MRI. TKE, estimated near the wall, has a strong linear relationship to the tWSS (mean R 2  = 0.84). Near-wall TKE estimates from MR simulations have good agreement to CFD-derived ground truth (mean R 2  = 0.90). Maps of near-wall TKE have strong visual correspondence to tWSS. Near-wall estimation of TKE permits assessment of relative maps of tWSS, but direct estimation of tWSS is challenging due to limitations in spatial resolution. Assessment of tWSS and near-wall TKE may open new avenues for analysis of different pathologies. Magn Reson Med 77:2310-2319, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  19. Degree of coupling in high-rise mixed shear walls structures

    Indian Academy of Sciences (India)

    assessment of the structural behaviour of coupled shear wall bents in mixed shear wall ... efficient lateral load resisting system against wind and earthquake effects. .... can be obtained from the second derivative of equation (11) which must be ...

  20. Vessel Wall Reaction after Vena Cava Filter Placement

    International Nuclear Information System (INIS)

    Hoekstra, Arend; Elstrodt, Jan M.; Nikkels, Peter G.J.; Tiebosch, Anton T.M.G.

    2002-01-01

    Purpose: To evaluate the interaction between the Cordis Keeper vena caval filter and vessel wall in aporcine model.Methods: Implantation of the filter was performed in five pigs. Radiologic data concerning inferior vena cava(IVC) diameter and filter patency, filter leg span, and stability were collected. At 2 or 6 months post-implantation, histopathologic analysis of the IVC wall was performed.Results: All filters remained patent with no evidence of migration. However, at 6 months follow-up, two legs of one filter penetrated the vessel wall and were adherent to the liver. These preliminary results suggest that with the observed gradual increase in the filter span, the risk of caval wall penetration increases with time, especially in a relatively small IVC(average diameter 16 mm).Conclusion: The Cordis Keeper filter was well tolerated, but seems to be prone to caval wall penetration in the long term

  1. A film-based wall shear stress sensor for wall-bounded turbulent flows

    Science.gov (United States)

    Amili, Omid; Soria, Julio

    2011-07-01

    In wall-bounded turbulent flows, determination of wall shear stress is an important task. The main objective of the present work is to develop a sensor which is capable of measuring surface shear stress over an extended region applicable to wall-bounded turbulent flows. This sensor, as a direct method for measuring wall shear stress, consists of mounting a thin flexible film on the solid surface. The sensor is made of a homogeneous, isotropic, and incompressible material. The geometry and mechanical properties of the film are measured, and particles with the nominal size of 11 μm in diameter are embedded on the film's surface to act as markers. An optical technique is used to measure the film deformation caused by the flow. The film has typically deflection of less than 2% of the material thickness under maximum loading. The sensor sensitivity can be adjusted by changing the thickness of the layer or the shear modulus of the film's material. The paper reports the sensor fabrication, static and dynamic calibration procedure, and its application to a fully developed turbulent channel flow at Reynolds numbers in the range of 90,000-130,000 based on the bulk velocity and channel full height. The results are compared to alternative wall shear stress measurement methods.

  2. Evolution of shear stress, protein expression, and vessel area in an animal model of arterial dilatation in hemodialysis grafts

    Science.gov (United States)

    Misra, Sanjay; Fu, Alex A.; Misra, Khamal D.; Glockner, James F.; Mukhopadyay, Debabrata

    2010-01-01

    Purpose To evaluate the wall shear stress, protein expression of matrix metalloproteinases-2 (MMP-2), -9 (MMP-9), and the inhibitors (tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), and -2 (TIMP-2)), and vessel area over time in a porcine model for hemodialysis polytetrafluoroethylene (PTFE) grafts. Materials and methods In 21 pigs, subtotal renal infarction was performed and 28 days later, a PTFE graft was placed to connect the carotid artery to the ipsilateral jugular vein. Phase contrast MR was used to measure blood flow and vessel area at 1, 3, 7, and 14 days after graft placement. Wall shear stress was estimated from Poiseuille’s law. Animals were sacrificed at day 3 (N=7), day 7 (N=7), and day 14 (N=7) and expression of MMP-2, MMP-9, TIMP-1, and TIMP-2 were determined at the grafted and control arteries. Results The mean wall shear stress of the grafted artery was higher than the control artery at all time points (P<0.05). It peaked by day 3 and decreased by days 7–14 as the vessel area nearly doubled. By days 7–14, there was a significant increase in active MMP-2 followed by a significant increase in pro and active MMP-9 by day 14 (P<0.05, grafted artery versus control). TIMP-1 expression peaked by day 7 and then decreased while TIMP-2 expression was decreased at days 7–14. Conclusions The wall shear stress of the grafted artery peaks by day 3 with increased MMP-2 activity by days 7–14 followed by pro and active MMP-9 by day 14 and the vessel area nearly doubled. PMID:20123196

  3. Finite element analyses for seismic shear wall international standard problem

    International Nuclear Information System (INIS)

    Park, Y.J.; Hofmayer, C.H.

    1998-04-01

    Two identical reinforced concrete (RC) shear walls, which consist of web, flanges and massive top and bottom slabs, were tested up to ultimate failure under earthquake motions at the Nuclear Power Engineering Corporation's (NUPEC) Tadotsu Engineering Laboratory, Japan. NUPEC provided the dynamic test results to the OECD (Organization for Economic Cooperation and Development), Nuclear Energy Agency (NEA) for use as an International Standard Problem (ISP). The shear walls were intended to be part of a typical reactor building. One of the major objectives of the Seismic Shear Wall ISP (SSWISP) was to evaluate various seismic analysis methods for concrete structures used for design and seismic margin assessment. It also offered a unique opportunity to assess the state-of-the-art in nonlinear dynamic analysis of reinforced concrete shear wall structures under severe earthquake loadings. As a participant of the SSWISP workshops, Brookhaven National Laboratory (BNL) performed finite element analyses under the sponsorship of the U.S. Nuclear Regulatory Commission (USNRC). Three types of analysis were performed, i.e., monotonic static (push-over), cyclic static and dynamic analyses. Additional monotonic static analyses were performed by two consultants, F. Vecchio of the University of Toronto (UT) and F. Filippou of the University of California at Berkeley (UCB). The analysis results by BNL and the consultants were presented during the second workshop in Yokohama, Japan in 1996. A total of 55 analyses were presented during the workshop by 30 participants from 11 different countries. The major findings on the presented analysis methods, as well as engineering insights regarding the applicability and reliability of the FEM codes are described in detail in this report. 16 refs., 60 figs., 16 tabs

  4. [Stem and progenitor cells in biostructure of blood vessel walls].

    Science.gov (United States)

    Korta, Krzysztof; Kupczyk, Piotr; Skóra, Jan; Pupka, Artur; Zejler, Paweł; Hołysz, Marcin; Gajda, Mariusz; Nowakowska, Beata; Barć, Piotr; Dorobisz, Andrzej T; Dawiskiba, Tomasz; Szyber, Piotr; Bar, Julia

    2013-09-18

    Development of vascular and hematopoietic systems during organogenesis occurs at the same time. During vasculogenesis, a small part of cells does not undergo complete differentiation but stays on this level, "anchored" in tissue structures described as stem cell niches. The presence of blood vessels within tissue stem cell niches is typical and led to identification of niches and ensures that they are functioning. The three-layer biostructure of vessel walls for artery and vein, tunica: intima, media and adventitia, for a long time was defined as a mechanical barrier between vessel light and the local tissue environment. Recent findings from vascular biology studies indicate that vessel walls are dynamic biostructures, which are equipped with stem and progenitor cells, described as vascular wall-resident stem cells/progenitor cells (VW-SC/PC). Distinct zones for vessel wall harbor heterogeneous subpopulations of VW-SC/PC, which are described as "subendothelial or vasculogenic zones". Recent evidence from in vitro and in vivo studies show that prenatal activity of stem and progenitor cells is not only limited to organogenesis but also exists in postnatal life, where it is responsible for vessel wall homeostasis, remodeling and regeneration. It is believed that VW-SC/PC could be engaged in progression of vascular disorders and development of neointima. We would like to summarize current knowledge about mesenchymal and progenitor stem cell phenotype with special attention to distribution and biological properties of VW-SC/PC in biostructures of intima, media and adventitia niches. It is postulated that in the near future, niches for VW-SC/PC could be a good source of stem and progenitor cells, especially in the context of vessel tissue bioengineering as a new alternative to traditional revascularization therapies.

  5. Stem and progenitor cells in biostructure of blood vessel walls

    Directory of Open Access Journals (Sweden)

    Krzysztof Korta

    2013-09-01

    Full Text Available Development of vascular and hematopoietic systems during organogenesis occurs at the same time. During vasculogenesis, a small part of cells does not undergo complete differentiation but stays on this level, “anchored” in tissue structures described as stem cell niches. The presence of blood vessels within tissue stem cell niches is typical and led to identification of niches and ensures that they are functioning. The three-layer biostructure of vessel walls for artery and vein, tunica: intima, media and adventitia, for a long time was defined as a mechanical barrier between vessel light and the local tissue environment. Recent findings from vascular biology studies indicate that vessel walls are dynamic biostructures, which are equipped with stem and progenitor cells, described as vascular wall-resident stem cells/progenitor cells (VW-SC/PC. Distinct zones for vessel wall harbor heterogeneous subpopulations of VW-SC/PC, which are described as “subendothelial or vasculogenic zones”. Recent evidence from in vitro and in vivo studies show that prenatal activity of stem and progenitor cells is not only limited to organogenesis but also exists in postnatal life, where it is responsible for vessel wall homeostasis, remodeling and regeneration. It is believed that VW-SC/PC could be engaged in progression of vascular disorders and development of neointima. We would like to summarize current knowledge about mesenchymal and progenitor stem cell phenotype with special attention to distribution and biological properties of VW-SC/PC in biostructures of intima, media and adventitia niches. It is postulated that in the near future, niches for VW-SC/PC could be a good source of stem and progenitor cells, especially in the context of vessel tissue bioengineering as a new alternative to traditional revascularization therapies.

  6. Shear localization and effective wall friction in a wall bounded granular flow

    Science.gov (United States)

    Artoni, Riccardo; Richard, Patrick

    2017-06-01

    In this work, granular flow rheology is investigated by means of discrete numerical simulations of a torsional, cylindrical shear cell. Firstly, we focus on azimuthal velocity profiles and study the effect of (i) the confining pressure, (ii) the particle-wall friction coefficient, (iii) the rotating velocity of the bottom wall and (iv) the cell diameter. For small cell diameters, azimuthal velocity profiles are nearly auto-similar, i.e. they are almost linear with the radial coordinate. Different strain localization regimes are observed : shear can be localized at the bottom, at the top of the shear cell, or it can be even quite distributed. This behavior originates from the competition between dissipation at the sidewalls and dissipation in the bulk of the system. Then we study the effective friction at the cylindrical wall, and point out the strong link between wall friction, slip and fluctuations of forces and velocities. Even if the system is globally below the sliding threshold, force fluctuations trigger slip events, leading to a nonzero wall slip velocity and an effective wall friction coefficient different from the particle-wall one. A scaling law was found linking slip velocity, granular temperature in the main flow direction and effective friction. Our results suggest that fluctuations are an important ingredient for theories aiming to capture the interface rheology of granular materials.

  7. Wall shear stress fixed points in blood flow

    Science.gov (United States)

    Arzani, Amirhossein; Shadden, Shawn

    2017-11-01

    Patient-specific computational fluid dynamics produces large datasets, and wall shear stress (WSS) is one of the most important parameters due to its close connection with the biological processes at the wall. While some studies have investigated WSS vectorial features, the WSS fixed points have not received much attention. In this talk, we will discuss the importance of WSS fixed points from three viewpoints. First, we will review how WSS fixed points relate to the flow physics away from the wall. Second, we will discuss how certain types of WSS fixed points lead to high biochemical surface concentration in cardiovascular mass transport problems. Finally, we will introduce a new measure to track the exposure of endothelial cells to WSS fixed points.

  8. Structural Alterations of the Glomerular Wall And Vessels in Early ...

    African Journals Online (AJOL)

    Structural Alterations of the Glomerular Wall And Vessels in Early Stages of Diabetes Mellitus: Light and Transmission Electron Microscopic Study. ... The second group of 20 (the experimental group) was injected intraperitoneally by a single dose of streptozotocin to induce hyperglycemia. Rats were sacrificed after ten days, ...

  9. Vessel wall reaction after vena cava filter placement

    NARCIS (Netherlands)

    Hoekstra, A; Elstrodt, JM; Nikkels, PGJ; Tiebosch, ATMG

    2002-01-01

    Purpose: To evaluate the interaction between the Cordis Keeper vena caval filter and vessel wall in a porcine model. Methods: Implantation of the filter was performed in five pigs. Radiologic data concerning inferior vena cava (IVC) diameter and filter patency, filter leg span, and stability were

  10. Platelet-vessel wall interaction in health and disease

    NARCIS (Netherlands)

    Löwenberg, E. C.; Meijers, J. C. M.; Levi, M. [=Marcel M.

    2010-01-01

    Upon vessel wall injury platelets rapidly adhere to the exposed subendothelial matrix which is mediated by several cellular receptors present on platelets or endothelial cells and various adhesive proteins such as von Willebrand factor, collagen and fibrinogen. Subsequent platelet activation results

  11. Experimental testing of anchoring devices for bottom rails in partially anchored timber frame shear walls

    OpenAIRE

    Caprolu, Giuseppe

    2011-01-01

    Källsner and Girhammar have presented a new plastic design method of wood-framed shear walls at ultimate limit state. This method allows the designer to calculate the load-carrying capacity of shear walls partially anchored, where the leading stud is not anchored against the uplift.The anchorage system of shear walls is provided from anchor bolts and hold downs. Anchor bolts provide horizontal shear continuity between the bottom rail and the foundation. Hold downs are directly connected from ...

  12. SIP Shear Walls: Cyclic Performance of High-Aspect-Ratio Segments and Perforated Walls

    Science.gov (United States)

    Vladimir Kochkin; Douglas R. Rammer; Kevin Kauffman; Thomas Wiliamson; Robert J. Ross

    2015-01-01

    Increasing stringency of energy codes and the growing market demand for more energy efficient buildings gives structural insulated panel (SIP) construction an opportunity to increase its use in commercial and residential buildings. However, shear wall aspect ratio limitations and lack of knowledge on how to design SIPs with window and door openings are barriers to the...

  13. SSI response of a typical shear wall structure

    International Nuclear Information System (INIS)

    Johnson, J.J.; Maslenikov, O.R.; Schewe, E.C.

    1985-01-01

    The seismic response of a typical shear structure in a commercial nuclear power plant was investigated for a series of site and foundation conditions using best estimate and design procedures. The structure selected is a part of the Zion AFT complex which is a connected group of reinforced concrete shear wall buildings, typical of nuclear power plant structures. Comparisons between best estimate responses quantified the effects of placing the structure on different sites and founding it in different manners. Calibration factors were developed by comparing simplified SSI design procedure responses to responses calculated by best estimate procedures. Nineteen basic cases were analyzed - each case was analyzed for ten earthquakes targeted to the NRC R.G. 1.60 design response spectra. The structure is a part of the Zion auxiliary-fuel handling turbine building (AFT) complex to the Zion nuclear power plants. (orig./HP)

  14. Application Problems of Anchor Dowels in Reinforced Concrete Shear Wall and Frame Connections

    OpenAIRE

    Musa H. Arslan

    2016-01-01

    Strengthening of the existing seismically deficient reinforced concrete (RC) buildings is an important issue in earthquake prone regions. Addition of RC shear wall as infill or external walls into the structural system has been a commonly preferred strengthening technique since the Big Erzincan Earthquake occurred in Turkey, 1992. The newly added rigid infill walls act primarily as shear walls and relieve the non-ductile existing frames from being subjected to large shear demands providing th...

  15. Prediction of wall shear stresses in transitional boundary layers using near-wall mean velocity profiles

    International Nuclear Information System (INIS)

    Jeon, Woo Pyung; Shin, Sung Ho; Kang, Shin Hyoung

    2000-01-01

    The local wall shear stress in transitional boundary layer was estimated from the near-wall mean velocity data using the principle of Computational Preston tube Method(CPM). The previous DNS and experimental databases of transitional boundary layers were used to demonstrate the accuracy of the method and to provide the applicable range of wall unit y + . The skin friction coefficients predicted by the CPM agreed well with those from previous studies. To reexamine the applicability of the CPM, near-wall hot-wire measurements were conducted in developing transitional boundary layers on a flat plate with different freestream turbulence intensities. The intermittency profiles across the transitional boundary layers were reasonably obtained from the conditional sampling technique. An empirical correlation between the representative intermittency near the wall and the free parameter K 1 of the extended wall function of CPM has been newly proposed using the present and other experimental data. The CPM has been verified as a useful tool to measure the wall shear stress in transitional boundary layer with reasonable accuracy

  16. SSI response of a typical shear wall structure. Volume 1

    International Nuclear Information System (INIS)

    Johnson, J.J.; Schewe, E.C.; Maslenikov, O.R.

    1984-04-01

    The Simplified Methods project of the US NRC-funded Seismic Safety Margins Research Program (SSMRP) has as its goal the development of a methodology to perform routine seismic probabilistic risk assessments of commercial nuclear power plants. The study reported here develops calibration factors to relate best estimate response to design values accounting for approximations and simplifications in SSI analysis procedures. Nineteen cases were analyzed and in-structure response compared. The structure of interest was a typical shear wall structure. 6 references, 44 figures, 22 tables

  17. Control of cracking in R.C. Structures: Numerical simulation of a squat shear wall

    NARCIS (Netherlands)

    Damoni, C.; Belletti, B.; Lilliu, G.

    2013-01-01

    In this paper the behavior of a squat shear wall subjected to monotonic shear loading is investigated. The study fits into the experimental program driven by CEOS.fr on modeling of the behavior of the tested mocks-ups (monotonic and cycling loading-under prevented or free shrinkage). The shear wall

  18. A control systems approach to quantify wall shear stress normalization by flow-mediated dilation in the brachial artery.

    Directory of Open Access Journals (Sweden)

    Frank C G van Bussel

    Full Text Available Flow-mediated dilation is aimed at normalization of local wall shear stress under varying blood flow conditions. Blood flow velocity and vessel diameter are continuous and opposing influences that modulate wall shear stress. We derived an index FMDv to quantify wall shear stress normalization performance by flow-mediated dilation in the brachial artery. In 22 fasting presumed healthy men, we first assessed intra- and inter-session reproducibilities of two indices pFMDv and mFMDv, which consider the relative peak and relative mean hyperemic change in flow velocity, respectively. Second, utilizing oral glucose loading, we evaluated the tracking performance of both FMDv indices, in comparison with existing indices [i.e., the relative peak diameter increase (%FMD, the peak to baseline diameter ratio (Dpeak/Dbase, and the relative peak diameter increase normalized to the full area under the curve of blood flow velocity with hyperemia (FMD/shearAUC or with area integrated to peak hyperemia (FMD/shearAUC_peak]. Inter-session and intra-session reproducibilities for pFMDv, mFMDv and %FMD were comparable (intra-class correlation coefficients within 0.521-0.677 range. Both pFMDv and mFMDv showed more clearly a reduction after glucose loading (reduction of ~45%, p≤0.001 than the other indices (% given are relative reductions: %FMD (~11%, p≥0.074; Dpeak/Dbase (~11%, p≥0.074; FMD/shearAUC_peak (~20%, p≥0.016 and FMD/shearAUC (~38%, p≤0.038. Further analysis indicated that wall shear stress normalization under normal (fasting conditions is already far from ideal (FMDv << 1, which (therefore does not materially change with glucose loading. Our approach might be useful in intervention studies to detect intrinsic changes in shear stress normalization performance in conduit arteries.

  19. Hierarchical order in wall-bounded shear turbulence

    International Nuclear Information System (INIS)

    Carbone, F.; Aubry, N.

    1996-01-01

    Since turbulence at realistic Reynolds numbers, such as those occurring in the atmosphere or in the ocean, involve a high number of modes that cannot be resolved computationally in the foreseeable future, there is a strong motivation for finding techniques which drastically decrease the number of such required modes, particularly under inhomogeneous conditions. The significance of this work is to show that wall-bounded shear turbulence, in its strongly inhomogeneous direction (normal to the wall), can be decomposed into one (or a few) space endash time mother mode(s), with each mother generating a whole family of modes by stretching symmetry. In other words, the generated modes are similar, dilated copies of their mother. In addition, we show that the nature of all previous modes strongly depends on the symmetry itself. These findings constitute the first scaling theory of inhomogeneous turbulence. copyright 1996 American Institute of Physics

  20. Intracranial arterial aneurysm vasculopathies: targeting the outer vessel wall

    International Nuclear Information System (INIS)

    Krings, Timo; Piske, Ronie L.; Lasjaunias, Pierre L.

    2005-01-01

    The pathogenesis of intracranial arterial aneurysms (AA) remains unclear, despite their clinical importance. An improved understanding of this disease is important in choosing therapeutic options. In addition to the ''classical'' berry-type aneurysm, there are various other types of intracranial AA such as infectious, dissecting or giant, partially-thrombosed aneurysms. From the clinician's perspective, the hypothesis that some of these intracranial AA might be due to abluminal factors has been proposed for several years. Indeed, this hypothesis and the empirical use of anti-inflammatory drugs in giant intracranial aneurysms have been confirmed by recent studies reporting that an enzyme involved in the inflammatory cascade (5-lipoxygenase or 5-LO) promotes the pathogenesis of specific aneurysms in humans. 5-LO generates different forms of leukotrienes which are potent mediators of inflammation. Adventitial inflammation leads to a weakening of the media from the abluminal part of the vessel wall due to the release of proinflammatory factors that invade the media, thereby degrading the extracellular matrix, the elastic lamina of the vascular wall, and, finally, the integrity of the vessel lumen. This in turn results in a dilation of the vessel and aneurysm formation. Moreover, neoangiogenesis of vasa vasorum is found in close proximity to 5-LO activated macrophages. In addition to this biological cascade, we argue that repeated subadventitial haemorrhages from the new vasa vasorum play an important role in aneurysm pathogenesis, due to a progressive increase in size mediated by the apposition of new layers of intramural haematoma within the vessel wall. Intracranial giant AA can therefore be regarded as a proliferative disease of the vessel wall induced by extravascular activity. (orig.)

  1. Computational scheme for transient temperature distribution in PWR vessel wall

    International Nuclear Information System (INIS)

    Dedovic, S.; Ristic, P.

    1980-01-01

    Computer code TEMPNES is a part of joint effort made in Gosa Industries in achieving the technique for structural analysis of heavy pressure vessels. Transient heat conduction problems analysis is based on finite element discretization of structures non-linear transient matrix formulation and time integration scheme as developed by Wilson (step-by-step procedure). Convection boundary conditions and the effect of heat generation due to radioactive radiation are both considered. The computation of transient temperature distributions in reactor vessel wall when the water temperature suddenly drops as a consequence of reactor cooling pump failure is presented. The vessel is treated as as axisymmetric body of revolution. The program has two finite time element options a) fixed predetermined increment and; b) an automatically optimized time increment for each step dependent on the rate of change of the nodal temperatures. (author)

  2. Molecular magnetic resonance imaging of atherosclerotic vessel wall disease

    Energy Technology Data Exchange (ETDEWEB)

    Noerenberg, Dominik [Charite - University Medicine Berlin, Department of Radiology, Berlin (Germany); University of Munich - Grosshadern, Department of Clinical Radiology, Munich (Germany); Ebersberger, Hans U. [Heart Center Munich-Bogenhausen, Department of Cardiology and Intensive Care Medicine, Munich (Germany); Diederichs, Gerd; Hamm, Bernd [Charite - University Medicine Berlin, Department of Radiology, Berlin (Germany); Botnar, Rene M. [King' s College London, Division of Imaging Sciences and Biomedical Engineering, London (United Kingdom); Makowski, Marcus R. [Charite - University Medicine Berlin, Department of Radiology, Berlin (Germany); King' s College London, Division of Imaging Sciences and Biomedical Engineering, London (United Kingdom)

    2016-03-15

    Molecular imaging aims to improve the identification and characterization of pathological processes in vivo by visualizing the underlying biological mechanisms. Molecular imaging techniques are increasingly used to assess vascular inflammation, remodeling, cell migration, angioneogenesis and apoptosis. In cardiovascular diseases, molecular magnetic resonance imaging (MRI) offers new insights into the in vivo biology of pathological vessel wall processes of the coronary and carotid arteries and the aorta. This includes detection of early vascular changes preceding plaque development, visualization of unstable plaques and assessment of response to therapy. The current review focuses on recent developments in the field of molecular MRI to characterise different stages of atherosclerotic vessel wall disease. A variety of molecular MR-probes have been developed to improve the non-invasive detection and characterization of atherosclerotic plaques. Specifically targeted molecular probes allow for the visualization of key biological steps in the cascade leading to the development of arterial vessel wall lesions. Early detection of processes which lead to the development of atherosclerosis and the identification of vulnerable atherosclerotic plaques may enable the early assessment of response to therapy, improve therapy planning, foster the prevention of cardiovascular events and may open the door for the development of patient-specific treatment strategies. (orig.)

  3. Molecular magnetic resonance imaging of atherosclerotic vessel wall disease

    International Nuclear Information System (INIS)

    Noerenberg, Dominik; Ebersberger, Hans U.; Diederichs, Gerd; Hamm, Bernd; Botnar, Rene M.; Makowski, Marcus R.

    2016-01-01

    Molecular imaging aims to improve the identification and characterization of pathological processes in vivo by visualizing the underlying biological mechanisms. Molecular imaging techniques are increasingly used to assess vascular inflammation, remodeling, cell migration, angioneogenesis and apoptosis. In cardiovascular diseases, molecular magnetic resonance imaging (MRI) offers new insights into the in vivo biology of pathological vessel wall processes of the coronary and carotid arteries and the aorta. This includes detection of early vascular changes preceding plaque development, visualization of unstable plaques and assessment of response to therapy. The current review focuses on recent developments in the field of molecular MRI to characterise different stages of atherosclerotic vessel wall disease. A variety of molecular MR-probes have been developed to improve the non-invasive detection and characterization of atherosclerotic plaques. Specifically targeted molecular probes allow for the visualization of key biological steps in the cascade leading to the development of arterial vessel wall lesions. Early detection of processes which lead to the development of atherosclerosis and the identification of vulnerable atherosclerotic plaques may enable the early assessment of response to therapy, improve therapy planning, foster the prevention of cardiovascular events and may open the door for the development of patient-specific treatment strategies. (orig.)

  4. Measurements of wall shear stress in a planar turbulent Couette flow with porous walls

    Science.gov (United States)

    Beuther, Paul

    2013-11-01

    Measurements of drag on a moving web in a multi-span festoon show a stronger than expected dependency on the porosity of the web. The experiments suggest a wall shear stress 3-4 times larger than non-porous webs or historical Couette flow data for solid walls. Previous DNS studies by Jimenez et al. (JFM Vol 442) of boundary layers with passive porous surfaces predict a much smaller increase in wall shear stress for a porous wall of only 40%. Other DNS studies by Quadrio et al. (JFM Vol 576) of porous walls with periodic transpiration do show a large increase in drag under certain periodic conditions of modest amplitude. Although those results are aligned in magnitude with this study, the exact reason for the observed high drag for porous webs in this present study is not understood because there was no external disturbance applied to the web. It can be hypothesized that natural flutter of the web results in a similar mechanism shown in the periodic DNS study, but when the natural flutter was reduced by increasing web tension, there was only a small decrease of the drag. A key difference in this study is that because of the multiple parallel spans in a festoon, any transpiration in one layer must act in the opposite manner on the adjacent span.

  5. Significance of Shear Wall in Multi-Storey Structure With Seismic Analysis

    Science.gov (United States)

    Bongilwar, Rajat; Harne, V. R.; Chopade, Aditya

    2018-03-01

    In past decades, shear walls are one of the most appropriate and important structural component in multi-storied building. Therefore, it would be very interesting to study the structural response and their systems in multi-storied structure. Shear walls contribute the stiffness and strength during earthquakes which are often neglected during design of structure and construction. This study shows the effect of shear walls which significantly affect the vulnerability of structures. In order to test this hypothesis, G+8 storey building was considered with and without shear walls and analyzed for various parameters like base shear, storey drift ratio, lateral displacement, bending moment and shear force. Significance of shear wall has been studied with the help of two models. First model is without shear wall i.e. bare frame and other another model is with shear wall considering opening also in it. For modeling and analysis of both the models, FEM based software ETABS 2016 were used. The analysis of all models was done using Equivalent static method. The comparison of results has been done based on same parameters like base shear, storey drift ratio, lateral displacement, bending moment and shear force.

  6. Influence of Coherent Structures on the Wall Shear Stress in Axial Flow Between a Cylinder and a Plane Wall

    International Nuclear Information System (INIS)

    Khabbouchi, Imed; Guellouz, Mohamed Sadok; Tavoularis, Stavros

    2009-01-01

    Synchronised hot-film and hot-wire measurements were made in the narrower region of a rectangular channel containing a cylindrical rod. The hot-film probe was mounted flush with the channel bottom wall to measure the wall shear stress, while the hot-wire probe was placed at a fixed position, selected in order to easily detect the passage of coherent structures. Mean and rms profiles of the wall shear stress show the influence of the gap to diameter ratio on their respective distributions. The latter presented peculiarities that could only be explained by the presence of coherent structures in the flow between the rod and the wall. Evidence of this presence is seen in the velocity power spectra. The strong influence of the coherent structures on the wall shear stress spatial and temporal distributions is established through velocity-wall shear stress cross-correlations functions and through conditionally sampled measurements

  7. A wall-crawling robot for reactor vessel inspection in advanced reactors

    International Nuclear Information System (INIS)

    Spelt, P.F.; Crane, C.; Feng, L.; Abidi, M.; Tosunoglu, S.

    1994-01-01

    A consortium of four universities and the Center for Engineering Systems Advanced Research of the Oak Ridge National Laboratory has designed a prototype wall-crawling robot to perform weld inspection in advanced nuclear reactors. Design efforts for the reactor vessel inspection robot (RVIR) concentrated on the Advanced Liquid Metal Reactor because it presents the most demanding environment in which such a robot must operate. The RVIR consists of a chassis containing two sets of suction cups that can alternately grasp the side of the vessel being inspected, providing both locomotion and steering functions. Sensors include three CCD cameras and a weld inspection device based on new shear-wave technology. The restrictions of the inspection environment presented major challenges to the team. These challenges were met in the prototype, which has been tested in a non-radiation, room-temperature mockup of the robot work environment and shown to perform as expected. (author)

  8. A wall-crawling robot for reactor vessel inspection in advanced reactors

    International Nuclear Information System (INIS)

    Spelt, P.F.; Crane, C.; Feng, L.; Abidi, M.; Tosunoglu, S.

    1994-01-01

    A consortium of four universities and the Center for Engineering Systems Advanced Research of the Oak Ridge National Laboratory has designed a prototype wall-crawling robot to perform weld inspection in advanced nuclear reactors. Design efforts for the reactor vessel inspection robot (RVIR) concentrated on the Advanced Liquid Metal Reactor because it presents the most demanding environment in which such a robot must operate. The RVIR consists of a chassis containing two sets of suction cups that can alternately grasp the side of the vessel being inspected, providing both locomotion and steering functions. Sensors include three CCD cameras and a weld inspection device based on new shear-wave technology. The restrictions of the inspection environment presented major challenges to the team. These challenges were met in the prototype, which has been tested in a non-radiation, room-temperature mockup of the robot work environment and shown to perform as expected

  9. Design optimization of a thin walled pressure vessel

    International Nuclear Information System (INIS)

    Sadiq, S.

    2001-01-01

    Design evaluation of a pressure vessel is not only to build confidence on its integrity but also to reduce structural weight and enhance the performance of the structure. Pressure vessel, e.g., a rocket motor not only has to withstand the high operating temperatures but it must also be able to survive the internal pressures and external aerodynamic forces and bending stresses during its operation in flight. A research program was devised to study the stresses, which are generated in a thin walled pressure vessel during actual operation and its simulation with cold testing technique, i.e., by means of hydrostatic testing employing electrical resistance strain gauges on the external surface of the cylinder. The objective of the research was to uphold the performance of the vessel by reducing its thickness from 6.09 to 5.5 mm (which of course reduces the safety factor margin from 1.8 to 1.5); thereby curtailing the overall structural weight and maintaining the efficiency of the vessel itself during its live operation. The techniques employed were hydrostatic testing, data acquisition system for obtaining data on strains from the electrical resistance strain gauges and later employing V on Mises yield criterion empirical relation to computer the stresses in hoop and longitudinal directions. (author)

  10. Shear strength of end slabs of prestressed concrete nuclear reactor vessels

    International Nuclear Information System (INIS)

    Reins, J.D.; Quiros, J.L. Jr.; Schnobrich, W.C.; Sozen, M.A.

    1976-07-01

    The report summarizes the experimental and part of the analytical work carried out in connection with an investigation of the structural strength of prestressed concrete reactor vessels. The project is part of the Prestressed Concrete Reactor Vessel Program of the Oak Ridge National Laboratory sponsored by ERDA. The objective of the current phase of the work is to develop procedures to determine the shear strength of flat end slabs of reactor vessels with penetrations

  11. Intimal hyperplasia and wall shear in arterial bypass graft distal anastomoses: an in vivo model study.

    Science.gov (United States)

    Keynton, R S; Evancho, M M; Sims, R L; Rodway, N V; Gobin, A; Rittgers, S E

    2001-10-01

    The observation of intimal hyperplasia at bypass graft anastomoses has suggested a potential interaction between local hemodynamics and vascular wall response. Wall shear has been particularly implicated because of its known effects upon the endothelium of normal vessels and, thus, was examined as to its possible role in the development of intimal hyperplasia in arterial bypass graft distal anastomoses. Tapered (4-7 mm I.D.) e-PTFE synthetic grafts 6 cm long were placed as bilateral carotid artery bypasses in six adult, mongrel dogs weighing between 25 and 30 kg with distal anastomotic graft-to-artery diameter ratios (DR) of either 1.0 or 1.5. Immediately following implantation, simultaneous axial velocity measurements were made in the toe and artery floor regions in the plane of the anastomosis at radial increments of 0.35 mm, 0.70 mm, and 1.05 mm using a specially designed 20 MHz triple crystal ultrasonic wall shear rate transducer Mean, peak, and pulse amplitude wall shear rates (WSRs), their absolute values, the spatial and temporal wall shear stress gradients (WSSG), and the oscillatory shear index (OSI) were computed from these velocity measurements. All grafts were harvested after 12 weeks implantation and measurements of the degree of intimal hyperplasia (IH) were made along the toe region and the artery floor of the host artery in 1 mm increments. While some IH occurred along the toe region (8.35+/-23.1 microm) and was significantly different between DR groups (p<0.003), the greatest amount occurred along the artery floor (81.6+/-106.5 microm, mean +/- S.D.) (p < 0.001) although no significant differences were found between DR groups. Linear regressions were performed on the paired IH and mean, peak, and pulse amplitude WSR data as well as the absolute mean, peak, and pulse amplitude WSR data from all grafts. The mean and absolute mean WSRs showed a modest correlation with IH (r = -0.406 and -0.370, respectively) with further improvements seen (r = -0

  12. Understanding the fluid mechanics behind transverse wall shear stress.

    Science.gov (United States)

    Mohamied, Yumnah; Sherwin, Spencer J; Weinberg, Peter D

    2017-01-04

    The patchy distribution of atherosclerosis within arteries is widely attributed to local variation in haemodynamic wall shear stress (WSS). A recently-introduced metric, the transverse wall shear stress (transWSS), which is the average over the cardiac cycle of WSS components perpendicular to the temporal mean WSS vector, correlates particularly well with the pattern of lesions around aortic branch ostia. Here we use numerical methods to investigate the nature of the arterial flows captured by transWSS and the sensitivity of transWSS to inflow waveform and aortic geometry. TransWSS developed chiefly in the acceleration, peak systolic and deceleration phases of the cardiac cycle; the reverse flow phase was too short, and WSS in diastole was too low, for these periods to have a significant influence. Most of the spatial variation in transWSS arose from variation in the angle by which instantaneous WSS vectors deviated from the mean WSS vector rather than from variation in the magnitude of the vectors. The pattern of transWSS was insensitive to inflow waveform; only unphysiologically high Womersley numbers produced substantial changes. However, transWSS was sensitive to changes in geometry. The curvature of the arch and proximal descending aorta were responsible for the principal features, the non-planar nature of the aorta produced asymmetries in the location and position of streaks of high transWSS, and taper determined the persistence of the streaks down the aorta. These results reflect the importance of the fluctuating strength of Dean vortices in generating transWSS. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Seismic Performance of Composite Shear Walls Constructed Using Recycled Aggregate Concrete and Different Expandable Polystyrene Configurations

    Directory of Open Access Journals (Sweden)

    Wenchao Liu

    2016-03-01

    Full Text Available The seismic performance of recycled aggregate concrete (RAC composite shear walls with different expandable polystyrene (EPS configurations was investigated. Six concrete shear walls were designed and tested under cyclic loading to evaluate the effect of fine RAC in designing earthquake-resistant structures. Three of the six specimens were used to construct mid-rise walls with a shear-span ratio of 1.5, and the other three specimens were used to construct low-rise walls with a shear-span ratio of 0.8. The mid-rise and low-rise shear walls consisted of an ordinary recycled concrete shear wall, a composite wall with fine aggregate concrete (FAC protective layer (EPS modules as the external insulation layer, and a composite wall with sandwiched EPS modules as the insulation layer. Several parameters obtained from the experimental results were compared and analyzed, including the load-bearing capacity, stiffness, ductility, energy dissipation, and failure characteristics of the specimens. The calculation formula of load-bearing capacity was obtained by considering the effect of FAC on composite shear walls as the protective layer. The damage process of the specimen was simulated using the ABAQUS Software, and the results agreed quite well with those obtained from the experiments. The results show that the seismic resistance behavior of the EPS module composite for shear walls performed better than ordinary recycled concrete for shear walls. Shear walls with sandwiched EPS modules had a better seismic performance than those with EPS modules lying outside. Although the FAC protective layer slightly improved the seismic performance of the structure, it undoubtedly slowed down the speed of crack formation and the stiffness degradation of the walls.

  14. In vivo 3-dimensional Magnetic Resonance Wall Shear Stress Estimation in Ascending Aortic Dilatation

    Science.gov (United States)

    Bieging, Erik T.; Frydrychowicz, Alex; Wentland, Andrew; Landgraf, Benjamin R.; Johnson, Kevin M.; Wieben, Oliver; François, Christopher J.

    2011-01-01

    Purpose To estimate surface-based wall shear stress (WSS) and evaluate flow patterns in ascending aortic dilatation (AscAD) using a high-resolution, time-resolved, three-dimensional (3D), three-directional velocity encoded, radially undersampled phase contrast magnetic resonance sequence (4D PC-MRI). Materials and Methods 4D PC-MRI was performed in 11 patients with AscAD (46.3±22.0 years) and 10 healthy volunteers (32.9±13.4 years) after written informed consent and IRB-approval. Following manual vessel wall segmentation of the ascending aorta (MATLAB, The Mathworks, Natick, MA), a 3D surface was created using spline interpolation. Spatial WSS variation based on surface division in 12 segments and temporal variation were evaluated in AscAD and normal aortas. Visual analysis of flow patterns was performed based on streamlines and particle traces using EnSight (v9.0, CEI, Apex, NC). Results AscAD was associated with significantly increased diastolic WSS, decreased systolic to diastolic WSS ratio, and delayed onset of peak WSS (all P wall of the ascending aorta. Vortical flow with highest velocities along the anterior wall and increased helical flow during diastole were observed in AscAD compared to controls. Conclusion Changes in WSS in the ascending aorta of AscAD correspond to observed alterations in flow patterns compared to controls. PMID:21563242

  15. Experimental report of precast prestressed concrete shear wall. Precast prestressed concrete taishinheki no jikken hokoku

    Energy Technology Data Exchange (ETDEWEB)

    Takada, K.; Komura, M.; Sakata, H.; Senoo, M. (Fudo Building Research Co. Ltd., Tokyo (Japan))

    1993-07-30

    The present report outlines the multi-story precast prestressed concrete earthquake-proof wall (PC shear wall system). The PC shear wall is a precast wall which internally contains the columns and beams as a unit. Therefore, the present system integrates the walls, columns and beams without beam-framing installation for the intermediate stories. It can simplify the concreting in site and ease the construction of building. For the system development, experiment was made on the deformation, sliding, yield strength and destruction state of the shear wall. Used were four types of test unit which are different in both reinforcement and connection methods. The test force was given by a hydraulically drawing jack. In the experiment, the four types were compared in destruction state, relation between load and deformation, yield strength, and strain of main column reinforcing bars and wall connection reinforcing bars. PC shear wall system-based design was studied from the experimental result. The shear wall in which there occurred both bending and shearing deformations was modeled by changing to a brace unit. Divided into bending deformation and shearing deformation, the deformation was calculated, which concluded that the shearing deformation dominates in the present system. 15 figs., 4 tabs.

  16. Welding distortion control in double walled KSTAR vacuum vessel fabrication

    International Nuclear Information System (INIS)

    Oh, D. W.; Lee, G. T.; Kim, H. K.; Yang, H. L.; Bak, J. S.

    2004-01-01

    The KSTAR(Korea Superconducting Tokamak Advanced Research) vacuum vessel is designed to be a double walled structure made of 12mm thick 316LN stainless steel with a D shaped cross-section about 4 m height. Vacuum vessel was pre-fabricated in two parts, 180 degree and 157.5 degree sectors in toroidal direction to meet the transportation purpose. These two parts have to be welded on site with ±2mm allowable fabrication tolerances. 1/3 scaled mock-up model was used to estimate the welding distortion and to ensure the weld quality of vacuum vessel. Gas Tungsten Arc Welding(GTAW), which has been approved by procedure qualification test, was used during mock-up test and vacuum vessel site fabrication. Welding distortion could be managed by allowing for distortion in opposite direction, by applying high restraint using lots of strong backs, by controlling the welding heat input with symmetrical welding sequence. The integrity of the site welding joint was assured by radiographic test, ultrasonic test and leak test with helium detecting method

  17. Modeling Force Transfer around Openings in Wood-Frame Shear Walls

    Science.gov (United States)

    Minghao Li; Frank Lam; Borjen Yeh; Tom Skaggs; Doug Rammer; James Wacker

    2012-01-01

    This paper presented a modeling study on force transfer around openings (FTAO) in wood-frame shear walls detailed for FTAO. To understand the load transfer in the walls, this study used a finite-element model WALL2D, which is able to model individual wall components, including framing members, sheathing panels, oriented panel-frame nailed connections, framing...

  18. Automated image segmentation and registration of vessel wall MRI for quantitative assessment of carotid artery vessel wall dimensions and plaque composition

    NARCIS (Netherlands)

    Klooster, Ronald van 't

    2014-01-01

    The main goal of this thesis was to develop methods for automated segmentation, registration and classification of the carotid artery vessel wall and plaque components using multi-sequence MR vessel wall images to assess atherosclerosis. First, a general introduction into atherosclerosis and

  19. Mean wall-shear stress measurements using the micro-pillar shear-stress sensor MPS3

    International Nuclear Information System (INIS)

    Große, S; Schröder, W

    2008-01-01

    A new sensor to measure the mean turbulent wall-shear stress in turbulent flows is described. The wall-shear stress sensor MPS 3 has been tested in a well-defined fully developed turbulent pipe flow at Reynolds numbers Re b based on the bulk velocity U b and the pipe diameter D in the range of Re b = 10 000–20 000. The results demonstrate a convincing agreement of the mean wall-shear stress obtained with the new sensor technique with analytical and experimental results from the literature. The sensor device consists of a flexible micro-pillar that extends from the wall into the viscous sublayer. Bending due to the exerting fluid forces, the pillar-tip deflection serves as a measure for the local wall-shear stress. The sensor concept, calibration techniques, the achievable accuracy and error estimates, the fields of application and the sensor limits will be discussed. Furthermore, a first estimate of the pillar dynamic response will be derived showing the potential of the sensor to also measure the turbulent fluctuating wall-shear stress

  20. Cyclic behavior of low rise concrete shear walls containing recycled coarse and fine aggregates

    NARCIS (Netherlands)

    Qiao, Qiyun; Cao, Wanlin; Qian, Zhiwei; Li, Xiangyu; Zhang, Wenwen; Liu, Wenchao

    2017-01-01

    In this study, the cyclic behaviors of low rise concrete shear walls using recycled coarse or fine aggregates were investigated. Eight low rise Recycled Aggregates Concrete (RAC) shear wall specimens were designed and tested under a cyclic loading. The following parameters were varied:

  1. Experimental testing of hold down devices for timber frame shear walls

    OpenAIRE

    Caprolu, Giuseppe

    2012-01-01

    Källsner and Girhammar [1] have presented a new plastic design method for wood-framed shear walls at ultimate limit state. This method allows the designer to calculate the load-carrying capacity of partially anchored shear walls, where the leading stud is not anchored against uplift. The anchorage system of shear walls is provided by anchor bolts in the bottom rail and hold downs at the leading stud. Anchor bolts provide horizontal shear continuity between the bottom rail and the foundation. ...

  2. Cell culture for three-dimensional modeling in rotating-wall vessels: an application of simulated microgravity

    Science.gov (United States)

    Schwarz, R. P.; Goodwin, T. J.; Wolf, D. A.

    1992-01-01

    High-density, three-dimensional cell cultures are difficult to grow in vitro. The rotating-wall vessel (RWV) described here has cultured BHK-21 cells to a density of 1.1 X 10(7) cells/ml. Cells on microcarriers were observed to grow with enhanced bridging in this batch culture system. The RWV is a horizontally rotated tissue culture vessel with silicon membrane oxygenation. This design results in a low-turbulence, low-shear cell culture environment with abundant oxygenation. The RWV has the potential to culture a wide variety of normal and neoplastic cells.

  3. Relation between wall shear stress and carotid artery wall thickening MRI versus CFD

    DEFF Research Database (Denmark)

    Cibis, Merih; Potters, Wouter V.; Selwaness, Mariana

    2016-01-01

    Wall shear stress (WSS), a parameter associated with endothelial function, is calculated by computational fluid dynamics (CFD) or phase-contrast (PC) MRI measurements. Although CFD is common in WSS (WSSCFD) calculations, PC-MRI-based WSS (WSSMRI) is more favorable in population studies; since...... it is straightforward and less time consuming. However, it is not clear if WSSMRI and WSSCFD show similar associations with vascular pathology. Our aim was to test the associations between wall thickness (WT) of the carotid arteries and WSSMRI and WSSCFD. The subjects (n=14) with an asymptomatic carotid plaque who...... underwent MRI scans two times within 4 years of time were selected from the Rotterdam Study. We compared WSSCFD and WSSMRI at baseline and follow-up. Baseline WSSMRI and WSSCFD values were divided into 3 categories representing low, medium and high WSS tertiles. WT of each tertile was compared by a one...

  4. Effects of flow unsteadiness on the wall shear stress

    International Nuclear Information System (INIS)

    Amiri, K; Cervantes, M J; Raisee, M

    2012-01-01

    Measurements were performed on pulsating fully turbulent flows in a pipe test rig with a diameter of 100 mm. Sinusoidal oscillatory flow at different frequencies was superimposed on a mean flow of averaged Reynolds number Re=20000 based on the pipe diameter. The measurements have been performed at different forcing frequencies (0.001 + < 0.08) covering all the oscillatory regimes; quasi-steady, relaxation, quasi laminar and high frequency. The amplitude of the flow oscillation was small enough to allow a linear response in the measurements, i.e., all flow parameters showed an oscillatory behavior at the frequency of the flow. The amplitude of the oscillatory flow was about 10% of the mean velocity in all cases. The results include mean and phase averaged values of different parameters. The centerline velocity was measured by a 2D LDA system. Hot film and constant temperature anemometry system was used to determine the wall shear stress. Bulk velocity and pressure gradient along the pipe were also acquired. The results showed a good agreement with the previous analytical, experimental and numerical results available in the literature.

  5. Analytical model for shear strength of end slabs of prestressed concrete nuclear reactor vessels

    International Nuclear Information System (INIS)

    Abdulrahman, H.O.; Sozen, M.A.; Schnobrich, W.C.

    1979-04-01

    The results are presented of an investigation of the behavior and strength of flat end slabs of cylindrical prestressed concrete nuclear reactor vessels. The investigation included tests of ten small-scale pressure vessels and development of a nonlinear finite-element model to simulate the deformation response and strength of the end slabs. Because earlier experimental studies had shown that the flexural strength of the end slab could be calculated using intelligible procedures, the emphasis of this investigation was on shear strength

  6. Physics of Transitional Shear Flows Instability and Laminar–Turbulent Transition in Incompressible Near-Wall Shear Layers

    CERN Document Server

    Boiko, Andrey V; Grek, Genrih R; Kozlov, Victor V

    2012-01-01

    Starting from fundamentals of classical stability theory, an overview is given of the transition phenomena in subsonic, wall-bounded shear flows. At first, the consideration focuses on elementary small-amplitude velocity perturbations of laminar shear layers, i.e. instability waves, in the simplest canonical configurations of a plane channel flow and a flat-plate boundary layer. Then the linear stability problem is expanded to include the effects of pressure gradients, flow curvature, boundary-layer separation, wall compliance, etc. related to applications. Beyond the amplification of instability waves is the non-modal growth of local stationary and non-stationary shear flow perturbations which are discussed as well. The volume continues with the key aspect of the transition process, that is, receptivity of convectively unstable shear layers to external perturbations, summarizing main paths of the excitation of laminar flow disturbances. The remainder of the book addresses the instability phenomena found at l...

  7. Analytical Study on the Beyond Design Seismic Capacity of Reinforced Concrete Shear Walls

    Energy Technology Data Exchange (ETDEWEB)

    Nugroho, Tino Sawaldi Adi [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of); Chi, Ho-Seok [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2015-10-15

    The OECD-NEA has organized an international benchmarking program to better understand this critical issue. The benchmark program provides test specimen geometry, test setup, material properties, loading conditions, recorded measures, and observations of the test specimens. The main objective of this research is to assess the beyond design seismic capacity of the reinforced concrete shear walls tested at the European Laboratory for Structural Assessment between 1997 and 1998 through participation in the OECD-NEA benchmark program. In this study, assessing the beyond design seismic capacity of reinforced concrete shear walls is performed analytically by comparing numerical results with experimental results. The seismic shear capacity of the reinforced concrete shear wall was predicted reasonably well using ABAQUS program. However, the proper calibration of the concrete material model was necessary for better prediction of the behavior of the reinforced concrete shear walls since the response was influenced significantly by the material constitutive model.

  8. Simulation of reinforced concrete short shear wall subjected to cyclic loading

    International Nuclear Information System (INIS)

    Parulekar, Y.M.; Reddy, G.R.; Vaze, K.K.; Pegon, P.; Wenzel, H.

    2014-01-01

    Highlights: • Prediction of the capacity of squat shear wall using tests and analysis. • Modification of model of concrete in the softening part. • Pushover analysis using softened truss theory and FE analysis is performed. • Modified concrete model gives reasonable accurate peak load and displacement. • The ductility, ultimate load and also crack pattern can be accurately predicted. - Abstract: This paper addresses the strength and deformation capacity of stiff squat shear wall subjected to monotonic and pseudo-static cyclic loading using experiments and analysis. Reinforced concrete squat shear walls offer great potential for lateral load resistance and the failure mode of these shear walls is brittle shear mode. Shear strength of these shear walls depend strongly on softening of concrete struts in principal compression direction due to principal tension in other direction. In this work simulation of the behavior of a squat shear wall is accurately predicted by finite element modeling by incorporating the appropriate softening model in the program. Modification of model of concrete in the softening part is suggested and reduction factor given by Vecchio et al. (1994) is used in the model. The accuracy of modeling is confirmed by comparing the simulated response with experimental one. The crack pattern generated from the 3D model is compared with that obtained from experiments. The load deflection for monotonic loads is also obtained using softened truss theory and compared with experimental one

  9. Comparison of theoretical and test results on shear wall seismic response

    International Nuclear Information System (INIS)

    Gantenbein, F.; Wang, F.; Dalbera, J.

    1991-01-01

    As reinforced concrete shear walls are important resisting components of buildings in nuclear power facilities, it is important to study their ultimate behavior under dynamic loading. An experimental and analytical work has been undertaken on shear walls with and without openings, in order to develop and validate their model. This paper is related to the walls without openings. While pretest calculations have already been reported (Wang and al. 1989) and the test results are given in Gantenbein and al. 1991, this paper is mainly related to the comparison of test and calculation results on the wall initial stiffness and the time history of the wall motion

  10. Cyclic Behavior of Low Rise Concrete Shear Walls Containing Recycled Coarse and Fine Aggregates.

    Science.gov (United States)

    Qiao, Qiyun; Cao, Wanlin; Qian, Zhiwei; Li, Xiangyu; Zhang, Wenwen; Liu, Wenchao

    2017-12-07

    In this study, the cyclic behaviors of low rise concrete shear walls using recycled coarse or fine aggregates were investigated. Eight low rise Recycled Aggregates Concrete (RAC) shear wall specimens were designed and tested under a cyclic loading. The following parameters were varied: replacement percentages of recycled coarse or fine aggregates, reinforcement ratio, axial force ratio and X-shaped rebars brace. The failure characteristics, hysteretic behavior, strength and deformation capacity, strain characteristics and stiffness were studied. Test results showed that the using of the Recycled Coarse Aggregates (RCA) and its replacement ratio had almost no influence on the mechanical behavior of the shear wall; however, the using of Recycled Fine Aggregates (RFA) had a certain influence on the ductility of the shear wall. When the reinforcement ratio increased, the strength and ductility also increased. By increasing the axial force ratio, the strength increased but the ductility decreased significantly. The encased brace had a significant effect on enhancing the RAC shear walls. The experimental maximum strengths were evaluated with existing design codes, it was indicated that the strength evaluation of the low rise RAC shear walls can follow the existing design codes of the conventional concrete shear walls.

  11. Cyclic Behavior of Low Rise Concrete Shear Walls Containing Recycled Coarse and Fine Aggregates

    Directory of Open Access Journals (Sweden)

    Qiyun Qiao

    2017-12-01

    Full Text Available In this study, the cyclic behaviors of low rise concrete shear walls using recycled coarse or fine aggregates were investigated. Eight low rise Recycled Aggregates Concrete (RAC shear wall specimens were designed and tested under a cyclic loading. The following parameters were varied: replacement percentages of recycled coarse or fine aggregates, reinforcement ratio, axial force ratio and X-shaped rebars brace. The failure characteristics, hysteretic behavior, strength and deformation capacity, strain characteristics and stiffness were studied. Test results showed that the using of the Recycled Coarse Aggregates (RCA and its replacement ratio had almost no influence on the mechanical behavior of the shear wall; however, the using of Recycled Fine Aggregates (RFA had a certain influence on the ductility of the shear wall. When the reinforcement ratio increased, the strength and ductility also increased. By increasing the axial force ratio, the strength increased but the ductility decreased significantly. The encased brace had a significant effect on enhancing the RAC shear walls. The experimental maximum strengths were evaluated with existing design codes, it was indicated that the strength evaluation of the low rise RAC shear walls can follow the existing design codes of the conventional concrete shear walls.

  12. Effect of FRP on the Energy Absorbed by Steel Shear Walls with Openings

    Directory of Open Access Journals (Sweden)

    Mojtaba Ghasemzadeh

    2015-06-01

    Full Text Available It’s for more than three decades that Steel Shear Walls are being used as lateral load resisting system. Definitely,the actual behavior of steel shear walls can be assessed using experimental results. However, solve many of phenomenon like this one should be done using mathematical and theoretical methods due to their special characteristics such as high expenses, lack of laboratory facilities and time limitations. In this study, the behavior of steel plate shear walls with openings in a one-story frame were evaluated and compared in various conditions. For this purpose, different values ​​for the opening in shear wall was considered and exposed to lateral displacement in ABAQUS as a comprehensive finite element software. Then, the impact of FRP arrangement on shear wall was evaluated to represent the structural behavior under various conditions. Result shows that, use of FRP sheets as parallel layers on both sides of shear wall has the best response on energy absorption, so that performance of the model was better than shear wall fully covered with FRP.

  13. Air permeability for a concrete shear wall after a damaging seismic load simulation cycle

    International Nuclear Information System (INIS)

    Girrens, S.P.; Farrar, C.R.

    1991-01-01

    A study was initiated to estimate air leakage, driven by wind-generated pressure gradients, from a seismically damaged concrete structure. This paper describes an experiment performed to measure the air permeability in a reinforced concrete shear wall, both before and after simulated seismic loading. Static load-cycle testing was used to simulate earthquake loading. Permeability measurements were made by pressurizing one side of the shear wall above atmospheric conditions and recording the transient-pressure decay. Air permeability measurements made on the shear wall before loading fell within the range of values for concrete permeability published in the literature. As long as the structure exhibited linear load-displacement response, no variation in the air permeability was detected. However, experimental results indicate that the air permeability in the shear wall increased by a factor of 40 after the wall had been damaged (cracked)

  14. Erosion and redeposition at the vessel walls in fusion devices

    International Nuclear Information System (INIS)

    Naujoks, D.; Behrisch, R.

    1995-01-01

    The plasma induced erosion and redeposition at the vessel walls in today's fusion devices have been investigated both with the computer simulation code ERO, and in experiments. Well prepared carbon probes with implanted and evaporated markers in the surface layers have been exposed in the scrape-off layer (SOL) of several tokamaks such as JET, TEXTOR and ASDEX-Upgrade. The main plasma parameters (electron density and temperature, impurity concentration in the SOL) are simultaneously determined. After exposure to single plasma discharges, erosion and redeposition of the marker material were measured by surface layer analysis with MeV ion beam techniques. The experimental results were compared with the results from the ERO code. The measured erosion/redeposition could be described with ERO, which takes into account the impurity concentration in the SOL, the dynamical change of the surface composition (causing a modification of the sputtering yield during the exposure) and ExB drift effects. ((orig.))

  15. Subclavian vein aneurysm secondary to a benign vessel wall hamartoma

    Energy Technology Data Exchange (ETDEWEB)

    Warren, Patrick [Nationwide Children' s Hospital, Section of Pediatric Interventional Radiology, Columbus, OH (United States); Spaeth, Maya [Nationwide Children' s Hospital, Section of Plastic and Reconstructive Surgery, Columbus, OH (United States); Prasad, Vinay [Nationwide Children' s Hospital, Section of Pediatric Pathology, Columbus, OH (United States); McConnell, Patrick [Nationwide Children' s Hospital, Section of Cardiothoracic Surgery, Columbus, OH (United States)

    2013-11-15

    Venous aneurysms are rare clinical entities, particularly in children, and their presentation and natural history often depend on the anatomical location and underlying etiology. We present a single case of a 12-year-old girl who presented with a palpable right supraclavicular mass. Imaging evaluation with CT, conventional venography, MRI and sonography revealed a large fusiform subclavian vein aneurysm with an unusual, mass-like fibrofatty component incorporated into the vessel wall. The girl ultimately required complete resection of the right subclavian vein with placement of a synthetic interposition graft. This case provides a radiology/pathology correlation of an entity that has not previously been described as well as an example of the utility of multiple imaging modalities to aid diagnosis and preoperative planning. (orig.)

  16. Statistical properties of wall shear stress fluctuations in turbulent channel flows

    International Nuclear Information System (INIS)

    Keirsbulck, L.; Labraga, L.; Gad-el-Hak, M.

    2012-01-01

    Highlights: ► Accurate measurements of instantaneous wall shear stress are conducted. ► LDA is used to measure near-wall streamwise velocity. ► Electrochemical probe is used to measure wall shear stress. ► Frequency response and non-uniform correction methods were used to provide an accurate, well-resolved wall-statistics database. ► Reynolds number dependency of the statistical wall quantities is investigated. - Abstract: Instantaneous velocity and wall shear stress measurements are conducted in a turbulent channel flow in the Kármán number range of Re τ = 74–400. A one-dimensional LDA system is used to measure the streamwise velocity fluctuations, and an electrochemical technique is utilized to measure the instantaneous wall shear stress. For the latter, frequency response and nonuniform correction methods are used to provide an accurate, well-resolved wall statistics database. The Reynolds number dependency of the statistical wall quantities is carefully investigated. The corrected relative wall shear stress fluctuations fit well with the best DNS data available and meet the need for clarification of the small discrepancy observed in the literature between the experimental and numerical results of such quantities. Higher-order statistics of the wall shear stress, spectra, and the turbulence kinetic energy budget at the wall are also investigated. The present paper shows that the electrochemical technique is a powerful experimental method for hydrodynamic studies involving highly unsteady flows. The study brings with it important consequences, especially in the context of the current debate regarding the appropriate scaling as well as the validation of new predictive models of near-wall turbulence.

  17. Study on Shear Performance of Cold-formed Steel Composite Wall with New Type of stud

    Science.gov (United States)

    Wang, Chungang; Yue, Sizhe; Liu, Hong; Zhang, Zhuangnan

    2018-03-01

    The shear resistance of single oriented-strand board wall and single gypsum board wall can be improved in different degrees by increasing strength of steel. The experimental data of literatures were used, and the test specimens had been simulated and validated by ABAQUS finite element analysis. According to the research, it showed that the compressive bearing capacity of the new stud composite wall was much better than the common stud composite wall, so the establishment and research of all models had been based on the new section stud. The analysis results show that when using new type of stud the shear resistance of the single oriented-strand board wall can be improved efficiently by increasing strength of steel, but the shear resistance of the single gypsum wall can be increased little.

  18. A new dedicated finite element for push-over analysis of reinforced concrete shear wall systems

    Directory of Open Access Journals (Sweden)

    Delal Doğru ORMANCI

    2016-06-01

    Full Text Available In this study, a finite element which has been analyzed based on anisotropic behavior of reinforced shear walls is developed. Element stiffness matrices were varied based on whether the element is in the tension or the compression zone of the cross-section. Nonlinear behavior of reinforced shear wall model is investigated under horizontal loads. This behavior is defined with a similar approach to plastic hinge assumption in frame structures that the finite element behaves lineer elastic between joints and plastic deformations are concentrated on joints as vertical plastic displacements. According to this acceptance, plastic behavior of reinforced shear wall occurs when the vertical strain reaches elastic strain limit. In the definition of finite element, displacement functions are chosen considering that the partition of shear walls just at floor levels, are enough for solution. Results of this study are compared with the solution obtained from a different computer programme and experimental results.

  19. Effect of tip clearance on wall shear stress of an axial LVAD

    Science.gov (United States)

    Sarath, S.; Vikas, R.

    2017-09-01

    Wall shear stress is a crucial parameter used for blood damage analysis, and typically a value of 400 Pa is set as a limit. Tip clearance is a major factor contributing to hemolysis and pump efficiency. In this study, different tip gap configurations are used to analyse the wall shear stress developed on the blade surface of a constant thickness blade design, and a varying thickness blade design using CFD analysis. It was found that, for a particular geometry, as the clearance gap reduces, flow rate over the high wall shear stress area decreases even though the high wall shear stress span is found to extend. For each design, the optimum clearance gap is iteratively attained, keeping the maximum WSS as a limiting factor. Thus a better pump designs is obtained, whose leakage flow patterns are lower than that of the initial design, hence also leading to higher pump efficiency.

  20. Effect of Wall Shear Stress on Corrosion Inhibitor Film Performance

    Science.gov (United States)

    Canto Maya, Christian M.

    In oil and gas production, internal corrosion of pipelines causes the highest incidence of recurring failures. Ensuring the integrity of ageing pipeline infrastructure is an increasingly important requirement. One of the most widely applied methods to reduce internal corrosion rates is the continuous injection of chemicals in very small quantities, called corrosion inhibitors. These chemical substances form thin films at the pipeline internal surface that reduce the magnitude of the cathodic and/or anodic reactions. However, the efficacy of such corrosion inhibitor films can be reduced by different factors such as multiphase flow, due to enhanced shear stress and mass transfer effects, loss of inhibitor due to adsorption on other interfaces such as solid particles, bubbles and droplets entrained by the bulk phase, and due to chemical interaction with other incompatible substances present in the stream. The first part of the present project investigated the electrochemical behavior of two organic corrosion inhibitors (a TOFA/DETA imidazolinium, and an alkylbenzyl dimethyl ammonium chloride), with and without an inorganic salt (sodium thiosulfate), and the resulting enhancement. The second part of the work explored the performance of corrosion inhibitor under multiphase (gas/liquid, solid/liquid) flow. The effect of gas/liquid multiphase flow was investigated using small and large scale apparatus. The small scale tests were conducted using a glass cell and a submersed jet impingement attachment with three different hydrodynamic patterns (water jet, CO 2 bubbles impact, and water vapor cavitation). The large scale experiments were conducted applying different flow loops (hilly terrain and standing slug systems). Measurements of weight loss, linear polarization resistance (LPR), and adsorption mass (using an electrochemical quartz crystal microbalance, EQCM) were used to quantify the effect of wall shear stress on the performance and integrity of corrosion inhibitor

  1. Direct displacement-based design of special composite RC shear walls with steel boundary elements

    Directory of Open Access Journals (Sweden)

    H. Kazemi

    2016-06-01

    Full Text Available Special composite RC shear wall (CRCSW with steel boundary elements is a kind of lateral force resisting structural system which is used in earthquake-prone regions. Due to their high ductility and energy dissipation, CRCSWs have been widely used in recent years by structural engineers. However, there are few studies in the literature on the seismic design of such walls. Although there are many studies in the literature on the Direct Displacement-Based Design (DDBD of RC structures, however, no study can be found on DDBD of CRCSWs. Therefore, the aim of present study is to evaluate the ability of DDBD method for designing CRCSWs. In this study, four special composite reinforced concrete shear walls with steel boundary elements of 4, 8, 12 and 16 story numbers were designed using the DDBD method for target drift of 2%. The seismic behavior of the four CRCSWs was studied using nonlinear time-history dynamic analyses. Dynamic analyses were performed for the mentioned walls using 7 selected earthquake records. The seismic design parameters considered in this study includes: lateral displacement profile, inelastic dynamic inter-story drift demand, failure pattern and the composite RC shear walls overstrength factor. For each shear wall, the overall overstrength factor was calculated by dividing the ultimate dynamic base shear demand (Vu by the base shear demand (Vd as per the Direct Displacement Based-Design (DDBD method. The results show that the DDBD method can be used to design CRCSWs safely in seismic regions with predicted behavior.

  2. Large scale structures in a turbulent boundary layer and their imprint on wall shear stress

    Science.gov (United States)

    Pabon, Rommel; Barnard, Casey; Ukeiley, Lawrence; Sheplak, Mark

    2015-11-01

    Experiments were performed on a turbulent boundary layer developing on a flat plate model under zero pressure gradient flow. A MEMS differential capacitive shear stress sensor with a 1 mm × 1 mm floating element was used to capture the fluctuating wall shear stress simultaneously with streamwise velocity measurements from a hot-wire anemometer traversed in the wall normal direction. Near the wall, the peak in the cross correlation corresponds to an organized motion inclined 45° from the wall. In the outer region, the peak diminishes in value, but is still significant at a distance greater than half the boundary layer thickness, and corresponds to a structure inclined 14° from the wall. High coherence between the two signals was found for the low-frequency content, reinforcing the belief that large scale structures have a vital impact on wall shear stress. Thus, estimation of the wall shear stress from the low-frequency velocity signal will be performed, and is expected to be statistically significant in the outer boundary layer. Additionally, conditionally averaged mean velocity profiles will be presented to assess the effects of high and low shear stress. This material is based upon work supported by the National Science Foundation Graduate Research Fellowship under Grant No. DGE-1315138.

  3. Analysis and seismic tests of composite shear walls with CFST columns and steel plate deep beams

    Science.gov (United States)

    Dong, Hongying; Cao, Wanlin; Wu, Haipeng; Zhang, Jianwei; Xu, Fangfang

    2013-12-01

    A composite shear wall concept based on concrete filled steel tube (CFST) columns and steel plate (SP) deep beams is proposed and examined in this study. The new wall is composed of three different energy dissipation elements: CFST columns; SP deep beams; and reinforced concrete (RC) strips. The RC strips are intended to allow the core structural elements — the CFST columns and SP deep beams — to work as a single structure to consume energy. Six specimens of different configurations were tested under cyclic loading. The resulting data are analyzed herein. In addition, numerical simulations of the stress and damage processes for each specimen were carried out, and simulations were completed for a range of location and span-height ratio variations for the SP beams. The simulations show good agreement with the test results. The core structure exhibits a ductile yielding mechanism characteristic of strong column-weak beam structures, hysteretic curves are plump and the composite shear wall exhibits several seismic defense lines. The deformation of the shear wall specimens with encased CFST column and SP deep beam design appears to be closer to that of entire shear walls. Establishing optimal design parameters for the configuration of SP deep beams is pivotal to the best seismic behavior of the wall. The new composite shear wall is therefore suitable for use in the seismic design of building structures.

  4. Seismic strengthening of RC structures with exterior shear walls

    Indian Academy of Sciences (India)

    Nowadays, most of the strengthening strategies are based on global ..... In the present work, sliding shear capacity was calculated based on the code formulations, ... This study has been carried out with the financial support of State Planning ...

  5. System for cooling the upper wall of a nuclear reactor vessel

    International Nuclear Information System (INIS)

    Pailla, Henri; Schaller, Karl; Vidard, Michel.

    1974-01-01

    A system for cooling the upper wall of the main vessel of a fast neutron reactor is described. This vessel is suspended from an upper shield by the upper wall. It includes coils carrying a coolant which are immersed in an intermediate liquid bathing the wall and contained in a tank integral with the vessel. At least one of the two cooling and intermediate liquids is a liquid metal. The main vessel is contained in a safety vessel, the space between the main and safety vessels is occluded in its upper part by an insulating shield placed under the tank. There is a liquid metal seal between the upper wall and the upper shield under the tank. This system has been specially designed for sodium cooled fast neutron reactors [fr

  6. Wall shear stress in portal vein of cirrhotic patients with portal hypertension.

    Science.gov (United States)

    Wei, Wei; Pu, Yan-Song; Wang, Xin-Kai; Jiang, An; Zhou, Rui; Li, Yu; Zhang, Qiu-Juan; Wei, Ya-Juan; Chen, Bin; Li, Zong-Fang

    2017-05-14

    To investigate wall shear stress (WSS) magnitude and distribution in cirrhotic patients with portal hypertension using computational fluid dynamics. Idealized portal vein (PV) system models were reconstructed with different angles of the PV-splenic vein (SV) and superior mesenteric vein (SMV)-SV. Patient-specific models were created according to enhanced computed tomography images. WSS was simulated by using a finite-element analyzer, regarding the blood as a Newtonian fluid and the vessel as a rigid wall. Analysis was carried out to compare the WSS in the portal hypertension group with that in healthy controls. For the idealized models, WSS in the portal hypertension group (0-10 dyn/cm 2 ) was significantly lower than that in the healthy controls (10-20 dyn/cm 2 ), and low WSS area (0-1 dyn/cm 2 ) only occurred in the left wall of the PV in the portal hypertension group. Different angles of PV-SV and SMV-SV had different effects on the magnitude and distribution of WSS, and low WSS area often occurred in smaller PV-SV angle and larger SMV-SV angle. In the patient-specific models, WSS in the cirrhotic patients with portal hypertension (10.13 ± 1.34 dyn/cm 2 ) was also significantly lower than that in the healthy controls ( P portal hypertension, the low WSS area extended to wider levels and the magnitude of WSS reached lower levels, thereby being more prone to disturbed flow occurrence. Cirrhotic patients with portal hypertension show dramatic hemodynamic changes with lower WSS and greater potential for disturbed flow, representing a possible causative factor of PV thrombosis.

  7. Shake-table testing of a self-centering precast reinforced concrete frame with shear walls

    Science.gov (United States)

    Lu, Xilin; Yang, Boya; Zhao, Bin

    2018-04-01

    The seismic performance of a self-centering precast reinforced concrete (RC) frame with shear walls was investigated in this paper. The lateral force resistance was provided by self-centering precast RC shear walls (SPCW), which utilize a combination of unbonded prestressed post-tensioned (PT) tendons and mild steel reinforcing bars for flexural resistance across base joints. The structures concentrated deformations at the bottom joints and the unbonded PT tendons provided the self-centering restoring force. A 1/3-scale model of a five-story self-centering RC frame with shear walls was designed and tested on a shake-table under a series of bi-directional earthquake excitations with increasing intensity. The acceleration response, roof displacement, inter-story drifts, residual drifts, shear force ratios, hysteresis curves, and local behaviour of the test specimen were analysed and evaluated. The results demonstrated that seismic performance of the test specimen was satisfactory in the plane of the shear wall; however, the structure sustained inter-story drift levels up to 2.45%. Negligible residual drifts were recorded after all applied earthquake excitations. Based on the shake-table test results, it is feasible to apply and popularize a self-centering precast RC frame with shear walls as a structural system in seismic regions.

  8. Exercise-mediated changes in conduit artery wall thickness in humans: role of shear stress

    NARCIS (Netherlands)

    Thijssen, D.H.J.; Dawson, E.A.; Munckhof, I.C. van den; Tinken, T.M.; Drijver, E. den; Hopkins, N.; Cable, N.T.; Green, D.J.

    2011-01-01

    Episodic increases in shear stress have been proposed as a mechanism that induces training-induced adaptation in arterial wall remodeling in humans. To address this hypothesis in humans, we examined bilateral brachial artery wall thickness using high-resolution ultrasound in healthy men across an

  9. The distribution of wall shear stress downstream of a change in roughness

    International Nuclear Information System (INIS)

    Loureiro, J.B.R.; Sousa, F.B.C.C.; Zotin, J.L.Z.; Silva Freire, A.P.

    2010-01-01

    In the present work, six different experimental techniques are used to characterize the non-equilibrium flow downstream of a rough-to-smooth step change in surface roughness. Over the rough surface, wall shear stress results obtained through the form drag and the Reynolds stress methods are shown to be mutually consistent. Over the smooth surface, reference wall shear stress data is obtained through two optical methods: linear velocity profiles obtained through laser-Doppler anemometry and a sensor surface, the diverging fringe Doppler sensor. The work shows that the two most commonly used methods to determine the wall shear stress, the log-law gradient method and the Reynolds shear stress method, are completely inappropriate in the developing flow region. Preston tubes, on the other hand, are shown to perform well in the region of a non-equilibrium flow.

  10. Plasma discharge in ferritic first wall vacuum vessel of the Hitachi Tokamak HT-2

    International Nuclear Information System (INIS)

    Abe, Mitsushi; Nakayama, Takeshi; Asano, Katsuhiko; Otsuka, Michio

    1997-01-01

    A tokamak discharge with ferritic material first wall was tried successfully. The Hitachi Tokamak HT-2 had a stainless steel SUS304 vacuum vessel and modified to have a ferritic plate first wall for experiments to investigate the possibility of ferritic material usage in magnetic fusion devices. The achieved vacuum pressure and times used for discharge cleaning was roughly identical with the stainless steel first wall or the original HT-2. We concluded that ferritic material vacuum vessel is possible for tokamaks. (author)

  11. Preliminary investigation of ultrasonic shear wave holography with a view to the inspection of pressure vessels

    International Nuclear Information System (INIS)

    Aldridge, E.E.; Clare, A.B.; Shepherd, D.A.

    1975-01-01

    The manner in which holography would fit into the general scheme of pressure vessel inspection is discussed. Compared to conventional A, B and C presentations holography requires a different processing of the ultrasonic signal and a mechanical scan which may be more demanding than that normally provided for a C display. Preliminary results are presented of the examination of artificial defects in steel plate using shear wave holography. (author)

  12. High wall shear stress and spatial gradients in vascular pathology: a review.

    Science.gov (United States)

    Dolan, Jennifer M; Kolega, John; Meng, Hui

    2013-07-01

    Cardiovascular pathologies such as intracranial aneurysms (IAs) and atherosclerosis preferentially localize to bifurcations and curvatures where hemodynamics are complex. While extensive knowledge about low wall shear stress (WSS) has been generated in the past, due to its strong relevance to atherogenesis, high WSS (typically >3 Pa) has emerged as a key regulator of vascular biology and pathology as well, receiving renewed interests. As reviewed here, chronic high WSS not only stimulates adaptive outward remodeling, but also contributes to saccular IA formation (at bifurcation apices or outer curves) and atherosclerotic plaque destabilization (in stenosed vessels). Recent advances in understanding IA pathogenesis have shed new light on the role of high WSS in pathological vascular remodeling. In complex geometries, high WSS can couple with significant spatial WSS gradient (WSSG). A combination of high WSS and positive WSSG has been shown to trigger aneurysm initiation. Since endothelial cells (ECs) are sensors of WSS, we have begun to elucidate EC responses to high WSS alone and in combination with WSSG. Understanding such responses will provide insight into not only aneurysm formation, but also plaque destabilization and other vascular pathologies and potentially lead to improved strategies for disease management and novel targets for pharmacological intervention.

  13. Effect of shear connectors on local buckling and composite action in steel concrete composite walls

    International Nuclear Information System (INIS)

    Zhang, Kai; Varma, Amit H.; Malushte, Sanjeev R.; Gallocher, Stewart

    2014-01-01

    Steel concrete composite (SC) walls are being used for the third generation nuclear power plants, and also being considered for small modular reactors. SC walls consist of thick concrete walls with exterior steel faceplates serving as reinforcement. These steel faceplates are anchored to the concrete infill using shear connectors, for example, headed steel studs. The steel faceplate thickness (t p ) and yield stress (F y ), and the shear connector spacing (s), stiffness (k s ), and strength (Q n ) determine: (a) the level of composite action between the steel plates and the concrete infill, (b) the development length of steel faceplates, and (c) the local buckling of the steel faceplates. Thus, the shear connectors have a significant influence on the behavior of composite SC walls, and should be designed accordingly. This paper presents the effects of shear connector design on the level of composite action and development length of steel faceplates in SC walls. The maximum steel plate slenderness, i.e., ratio of shear connector spacing-to-plate thickness (s/t p ) ratio to prevent local buckling before yielding is also developed based on the existing experimental database and additional numerical analysis

  14. Effect of shear connectors on local buckling and composite action in steel concrete composite walls

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Kai, E-mail: kai-zh@purdue.edu [School of Civil Engineering, Purdue University, West Lafayette, IN (United States); Varma, Amit H., E-mail: ahvarma@purdue.edu [School of Civil Engineering, Purdue University, West Lafayette, IN (United States); Malushte, Sanjeev R., E-mail: smalusht@bechtel.com [Bechtel Power Corporation, Frederick, MD (United States); Gallocher, Stewart, E-mail: stewart.gallocher@steelbricks.com [Modular Walling Systems Ltd., Glasgow (United Kingdom)

    2014-04-01

    Steel concrete composite (SC) walls are being used for the third generation nuclear power plants, and also being considered for small modular reactors. SC walls consist of thick concrete walls with exterior steel faceplates serving as reinforcement. These steel faceplates are anchored to the concrete infill using shear connectors, for example, headed steel studs. The steel faceplate thickness (t{sub p}) and yield stress (F{sub y}), and the shear connector spacing (s), stiffness (k{sub s}), and strength (Q{sub n}) determine: (a) the level of composite action between the steel plates and the concrete infill, (b) the development length of steel faceplates, and (c) the local buckling of the steel faceplates. Thus, the shear connectors have a significant influence on the behavior of composite SC walls, and should be designed accordingly. This paper presents the effects of shear connector design on the level of composite action and development length of steel faceplates in SC walls. The maximum steel plate slenderness, i.e., ratio of shear connector spacing-to-plate thickness (s/t{sub p}) ratio to prevent local buckling before yielding is also developed based on the existing experimental database and additional numerical analysis.

  15. Development of Generalized Correlation Equation for the Local Wall Shear Stress

    International Nuclear Information System (INIS)

    Jeon, Yu Mi; Park, Ju Hwan

    2010-06-01

    The pressure drop characteristics for a fuel channel are essential for the design and reliable operation of a nuclear reactor. Over several decades, analytical methods have been developed to predict the friction factor in the fuel bundle flows. In order to enhance the accuracy of prediction for the pressure drop in a rod bundle, the influences of a channel wall and the local shear stress distribution should be considered. Therefore, the correlation equation for a local wall shear stress distribution should be developed in order to secure an analytical solution for the friction factor of a rod bundle. For a side subchannel, which has the influence of the channel wall, the local wall shear stress distribution is dependent on the ratio of wall to diameter (W/D) as well as the ratio of pitch to diameter (P/D). In the case that W/D has the same value with P/D, the local shear stress distribution can be simply correlated with the function of angular position for each value of P/D. While in the case where W/D has a different value than P/D, the correlation equation should be developed for each case of P/D and W/D. Therefore, in the present study, the generalized correlation equation of the local wall shear stress distribution was developed for a side subchannel in the case where W/D has a different value than P/D. Consequently, the generalized correlation equation of a local wall shear stress distribution can be represented by the equivalent pitch to diameter ratio, P'/D for the case that P/D and W/D had a different value

  16. Behaviour of Viscoelastic - Viscoplastic Spheres and Cylinders - Partly Plastic Vessel Walls

    DEFF Research Database (Denmark)

    Ottosen, N. Saabye

    1985-01-01

    The material model consists of a viscoelastic Burgers element and an additional viscoplastic Bingham element when the effective stress exceeds the yield stress. For partly plastic vessel walls, expressions are derived for the stress and strain state in pressurised or relaxation loaded thick......-walled cylinders in plane strain and spheres. For the spherical problem, the material compressibility is accounted for. The influence of the different material parameters on the behaviour of the vessels is evaluated. It is shown that the magnitude of the Maxwell viscosity is of major importance for the long......-term behaviour of thick-walled partly plastic vessels....

  17. Behaviour of Viscoelastic - Viscoplastic Spheres and Cylinders - Fully Plastic Vessel Walls

    DEFF Research Database (Denmark)

    Ottosen, N. Saabye

    1985-01-01

    The material model consists of a viscoelastic Burgers element and an additional viscoplastic Bingham element when the effective stress exceeds the yield stress. For fully plastic vessel walls, exact closed-form expressions arc derived for the stress and strain state in pressurised or relaxation...... loaded thick-walled cylinders in plane strain and spheres. For the spherical problem, the material compressibility is accounted for. The influence of the different material parameters on the behaviour of the vessels is evaluated. It is shown that the magnitude of the Maxwell viscosity is of major...... importance for the long-term behaviour of thick-walled fully plastic vessels....

  18. Ultimate shearing strength of aseismatic walls with many small holes for reactor buildings

    International Nuclear Information System (INIS)

    Yoshizaki, Seiji; Ezaki, Tetsuro; Korenaga, Takeyoshi; Sotomura, Kentaro.

    1984-01-01

    The aseismatic walls for reactor buildings have complicated forms, and are characterized by large wall thickness and high reinforcement ratio as compared with ordinary aseismatic walls. The forms are mainly box, cylinder or irregular polygonal prism and their combination. The design of the walls with many small holes has been performed on the basis of the reinforced concrete structure calculation standard of the Architectural Institute of Japan, following the case with large opening. When there are many small holes, the arrangement of reinforcement for the openings becomes complex, and the construction is difficult. It is necessary to rationalize the design and to simplify the reinforcement work. Under the background like this, the experiment to examine the shearing property in bending of the aseismatic walls with many small holes for reactor buildings was carried out, and horizontal loading test was performed on 43 specimens. The method of calculating the ultimate shearing strength of a wall without opening was proposed, and the method of applying it to a wall with many small holes is shown. The experimental method and the results, the examination of the experimental results, and the ultimate shearing strength of the aseismatic walls are reported. (Kako, I.)

  19. Effects of opening in shear walls of 30- storey building

    OpenAIRE

    Ruchi Sharma; Jignesh A Amin

    2015-01-01

    Tall towers and multi-storey buildings have fascinated mankind from the beginning of civilization, their construction being initially for defense and subsequently for ecclesiastical purposes. These tall buildings because of its height, is affected by lateral forces due to wind or earthquake actions tends to snap the building in shear and push it over in bending. In general, the rigidity (i.e. Resistance to lateral deflection) and stability (i.e. Resistance to overturning moments) requirement ...

  20. Extremely high wall-shear stress events in a turbulent boundary layer

    Science.gov (United States)

    Pan, Chong; Kwon, Yongseok

    2018-04-01

    The present work studies the fluctuating characteristics of the streamwise wall-shear stress in a DNS of a turbulent boundary layer at Re τ =1500 from a structural view. The two-dimensional field of the fluctuating friction velocity u‧ τ (x,z) is decomposed into the large- and small-scale components via a recently proposed scale separation algorithm, Quasi-bivariate Variational Mode Decomposition (QB-VMD). Both components are found to be dominated by streak-like structures, which can be regarded as the wall signature of the inner-layer streaks and the outer-layer LSMs, respectively. Extreme positive/negative wall-shear stress fluctuation events are detected in the large-scale component. The former’s occurrence frequency is nearly one order of magnitude higher than the latter; therefore, they contribute a significant portion of the long tail of the wall-shear stress distribution. Both two-point correlations and conditional averages show that these extreme positive wall-shear stress events are embedded in the large-scale positive u‧ τ streaks. They seem to be formed by near-wall ‘splatting’ process, which are related to strong finger-like sweeping (Q4) events originated from the outer-layer positive LSMs.

  1. Role of Wall Shear Stress in Cryptosporidium parvum Oocyst Attachment to Environmental Biofilms.

    Science.gov (United States)

    Luo, Xia; Jedlicka, Sabrina S; Jellison, Kristen L

    2017-12-15

    This study investigated Cryptosporidium parvum oocyst deposition onto biofilms as a function of shear stress under laminar or turbulent flow. Annular rotating bioreactors were used to grow stabilized stream biofilms at shear stresses ranging from 0.038 to 0.46 Pa. These steady-state biofilms were then used to assess the impact of hydrodynamic conditions on C. parvum oocyst attachment. C. parvum deposition onto biofilms followed a pseudo-second-order model under both laminar (after a lag phase) and turbulent flows. The total number of oocysts attached to the biofilm at steady state decreased as the hydrodynamic wall shear stress increased. The oocyst deposition rate constant increased with shear stress but decreased at high shear, suggesting that increasing wall shear stress results in faster attachment of Cryptosporidium due to higher mass transport until the shear forces exceed a critical limit that prevents oocyst attachment. These data show that oocyst attachment in the short and long term are impacted differently by shear: higher shear (to a certain limit) may be associated with faster initial oocyst attachment, but lower shear is associated with greater numbers of oocysts attached at equilibrium. IMPORTANCE This research provides experimental evidence to demonstrate that shear stress plays a critical role in protozoan-pathogen transport and deposition in environmental waters. The data presented in this work expand scientific understanding of Cryptosporidium attachment and fate, which will further influence the development of timely and accurate sampling strategies, as well as advanced water treatment technologies, to target protozoan pathogens in surface waters that serve as municipal drinking water sources. Copyright © 2017 American Society for Microbiology.

  2. Flow rate dependency of critical wall shear stress in a radial-flow cell

    DEFF Research Database (Denmark)

    Detry, J.G.; Jensen, Bo Boye Busk; Sindic, M.

    2009-01-01

    In the present work, a radial-flow cell was used to study the removal of starch particle aggregates from several solid substrates (glass, stainless steel, polystyrene and PTFE) in order to determine the critical wall shear stress value for each case. The particle aggregates were formed by aspersion...... of a water or ethanol suspension of starch granules on the surfaces. Depending on the substrate and on the suspending liquid, the aggregates differed in size and shape. Aggregate removal was studied at two flow rates. At the lower flow rate (Re-inlet = 955), the values of critical wall shear stress...... for the different surfaces suggested that capillary forces were, for all of them, playing an important role in aggregate adhesion since aqueous based aggregates were always more difficult to remove. At the higher flow rate (Re-inlet = 2016) the critical wall shear stress increased as a result of the change...

  3. Investigation of the Behavior of Steel Shear Walls Using Finite Elements Analysis

    Directory of Open Access Journals (Sweden)

    K. Abubakri

    2016-10-01

    Full Text Available Currently, steel shear walls are considered by engineers as an economic method against lateral loads imposed by wind and earthquake in tall structures. Accordingly, there is a growing need to develop accurate methods alongside approximation methods to estimate the behavior of these structural elements. The finite element technique is one of the strongest numerical methods in analysis of solid mechanics problems. Finite element analysis however requires high technical knowledge of the behavioral models of materials. Therefore, it is less used by designers for certain structural elements such as steel shear walls. This study examines the failure mechanism of steel shear walls using finite elements analysis and validates this modeling by comparing the results with experimental studies.

  4. Evaluation of Shear Wall-RC Frame Interaction of High-Rise Buildings using 2-D model Approach

    Directory of Open Access Journals (Sweden)

    Dipali Patel

    2015-09-01

    Full Text Available The usefulness of structural walls in the framing of buildings has long been recognized. It is generally preferred to use shear wall in combination with moment resisting frame. In the present study, an effort is also made to investigate the shear wall-RC frame interaction using 2-D modeling of 20, 30 and 35 storey RC frame building with shear wall. In equivalent simplified 2-D model, two exterior frames with shear wall modeled as single frame with double stiffness, strength and weight. The interior frames without shear wall are modeled as a single frame with equivalent stiffness, strength and weight. The modeled frames are connected with rigid link at each floor level. Using 2-D plane frame model the lateral force distribution between Exterior frame with shear wall and Interior frame without shear wall is investigated. From the analysis, it is observed that up to bottom seven/eight storey more than 50% load is taken by frame with shear wall and the lower most three storeys take about 75% of total storey shear.

  5. Hydraulic properties of 3D rough-walled fractures during shearing: An experimental study

    Science.gov (United States)

    Yin, Qian; Ma, Guowei; Jing, Hongwen; Wang, Huidong; Su, Haijian; Wang, Yingchao; Liu, Richeng

    2017-12-01

    This study experimentally analyzed the influence of shear processes on nonlinear flow behavior through 3D rough-walled rock fractures. A high-precision apparatus was developed to perform stress-dependent fluid flow tests of fractured rocks. Then, water flow tests on rough-walled fractures with different mechanical displacements were conducted. At each shear level, the hydraulic pressure ranged from 0 to 0.6 MPa, and the normal load varied from 7 to 35 kN. The results show that (i) the relationship between the volumetric flow rate and hydraulic gradient of rough-walled fractures can be well fit using Forchheimer's law. Notably, both the linear and nonlinear coefficients in Forchheimer's law decrease during shearing; (ii) a sixth-order polynomial function is used to evaluate the transmissivity based on the Reynolds number of fractures during shearing. The transmissivity exhibits a decreasing trend as the Reynolds number increases and an increasing trend as the shear displacement increases; (iii) the critical hydraulic gradient, critical Reynolds number and equivalent hydraulic aperture of the rock fractures all increase as the shear displacement increases. When the shear displacement varies from 0 to 15 mm, the critical hydraulic gradient ranges from 0.3 to 2.2 for a normal load of 7 kN and increases to 1.8-8.6 for a normal load of 35 kN; and (iv) the Forchheimer law results are evaluated by plotting the normalized transmissivity of the fractures during shearing against the Reynolds number. An increase in the normal load shifts the fitted curves downward. Additionally, the Forchheimer coefficient β decreases with the shear displacement but increases with the applied normal load.

  6. Benchmark study of shear buckling of a cylindrical vessel. Part 2

    International Nuclear Information System (INIS)

    Combescure, A.; Bastien, R.; Carnoy, E.G.; Dostal, M.; Austin, N.M.; Peano, A.; Angeloni, P.

    1988-01-01

    In Liquid Metal Fast Breeder Reactors (LMFBR) potential shear buckling failures of the primary vessel, induced through seismic excitations, have to be considered. The primary vessel material, typically 316 stainless steel, has a low yield strength at the normal operating temperatures of around 400 0 C to 500 0 C. There characteristics tend to make the structure relatively flexible and subject to potential elasto-plastic shear buckling failure. The use of finite element techniques in buckling analyses is currently becoming more accepted. There are at present many finite element codes available which have the capacibility to solve buckling problems. The objective of the study reported herein was to follow on from the previous code validation exercise and investigate the ability of finite element codes to predict buckling behaviour in another test cylinder [a/h = 83, a/L = 1] where non-linear effects would be more significant and plastic shear buckling could be a failure mode. As before four organisations took part in the code validation exercise. NNC [UK] and ISMES [Italy] used the commercially available general purpose FE code ABAQUS. CEA [France] used INCA and BILBO which are members of the commercially available CASTEM suite of FE program. Novatome [France] used their in-house FE code NOVNL. The joint effort was co-ordinated by NNC with the assistance of the Commission of the European Communities Working on Codes and Standards AG2

  7. Correlation between vortices and wall shear stress in a curved artery model under pulsatile flow conditions

    Science.gov (United States)

    Cox, Christopher; Plesniak, Michael W.

    2017-11-01

    One of the most physiologically relevant factors within the cardiovascular system is the wall shear stress. The wall shear stress affects endothelial cells via mechanotransduction and atherosclerotic regions are strongly correlated with curvature and branching in the human vasculature, where the shear stress is both oscillatory and multidirectional. Also, the combined effect of curvature and pulsatility in cardiovascular flows produces unsteady vortices. In this work, our goal is to assess the correlation between multiple vortex pairs and wall shear stress. To accomplish this, we use an in-house high-order flux reconstruction Navier-Stokes solver to simulate pulsatile flow of a Newtonian blood-analog fluid through a rigid 180° curved artery model. We use a physiologically relevant flow rate and generate results using both fully developed and uniform entrance conditions, the latter motivated by the fact that flow upstream to a curved artery may not be fully developed. Under these two inflow conditions, we characterize the evolution of various vortex pairs and their subsequent effect on several wall shear stress metrics. Supported by GW Center for Biomimetics and Bioinspired Engineering.

  8. Quantification of common carotid artery and descending aorta vessel wall thickness from MR vessel wall imaging using a fully automated processing pipeline.

    Science.gov (United States)

    Gao, Shan; van 't Klooster, Ronald; Brandts, Anne; Roes, Stijntje D; Alizadeh Dehnavi, Reza; de Roos, Albert; Westenberg, Jos J M; van der Geest, Rob J

    2017-01-01

    To develop and evaluate a method that can fully automatically identify the vessel wall boundaries and quantify the wall thickness for both common carotid artery (CCA) and descending aorta (DAO) from axial magnetic resonance (MR) images. 3T MRI data acquired with T 1 -weighted gradient-echo black-blood imaging sequence from carotid (39 subjects) and aorta (39 subjects) were used to develop and test the algorithm. The vessel wall segmentation was achieved by respectively fitting a 3D cylindrical B-spline surface to the boundaries of lumen and outer wall. The tube-fitting was based on the edge detection performed on the signal intensity (SI) profile along the surface normal. To achieve a fully automated process, Hough Transform (HT) was developed to estimate the lumen centerline and radii for the target vessel. Using the outputs of HT, a tube model for lumen segmentation was initialized and deformed to fit the image data. Finally, lumen segmentation was dilated to initiate the adaptation procedure of outer wall tube. The algorithm was validated by determining: 1) its performance against manual tracing; 2) its interscan reproducibility in quantifying vessel wall thickness (VWT); 3) its capability of detecting VWT difference in hypertensive patients compared with healthy controls. Statistical analysis including Bland-Altman analysis, t-test, and sample size calculation were performed for the purpose of algorithm evaluation. The mean distance between the manual and automatically detected lumen/outer wall contours was 0.00 ± 0.23/0.09 ± 0.21 mm for CCA and 0.12 ± 0.24/0.14 ± 0.35 mm for DAO. No significant difference was observed between the interscan VWT assessment using automated segmentation for both CCA (P = 0.19) and DAO (P = 0.94). Both manual and automated segmentation detected significantly higher carotid (P = 0.016 and P = 0.005) and aortic (P < 0.001 and P = 0.021) wall thickness in the hypertensive patients. A reliable and reproducible pipeline for fully

  9. Wall shear stress measurement of near-wall flow over inclined and curved boundaries by stereo interfacial particle image velocimetry

    International Nuclear Information System (INIS)

    Nguyen, Thien Duy; Wells, John Craig; Nguyen, Chuong Vinh

    2010-01-01

    In investigations of laminar or turbulent flows, wall shear is often important. Nevertheless, conventional particle image velocimetry (PIV) is difficult in near-wall regions. A near-wall measurement technique, named interfacial PIV (IPIV) [Nguyen, C., Nguyen, T., Wells, J., Nakayama, A., 2008. Proposals for PIV of near-wall flow over curved boundaries. In: Proceedings of 14th International Symposium on Applications of Laser Technique to Fluid Mechanics], handles curved boundaries by means of conformal transformation, directly measures the wall gradient, and yields the near-wall tangential velocity profile at one-pixel resolution. In this paper, we show the feasibility of extending IPIV to measure wall gradients by stereo reconstruction. First, we perform a test on synthetic images generated from a direct numerical simulation (DNS) snapshot of turbulent flow over sinusoidal bed. Comparative assessment of wall gradients derived by IPIV, stereo-IPIV and particle image distortion (PID) [Huang, H.T., Fiedler, H.E., Wang, J.J., 1993. Limitation and improvement of PIV. Experiments in Fluids 15(4), 263-273] is evaluated with DNS data. Also, the sensitivity of IPIV and stereo-IPIV results to the uncertainty of identified wall position is examined. As a practical application of IPIV and stereo-IPIV to experimental images, results from turbulent open channel flow over a backward-facing step are discussed in detail.

  10. Measurement and analysis of flow wall shear stress in an interior subchannel of triangular array rods

    International Nuclear Information System (INIS)

    Fakori-Monazah, M.R.; Todreas, N.E.

    1977-08-01

    A simulated model of triangular array rods with pitch to diameter ratio of 1.10 (as a test section) and air as the fluid flow was used to study the LMFBR hydraulic parameters. The wall shear stress distribution around the rod periphery, friction factors, static pressure distributions and turbulence intensity corresponding to various Reynolds numbers ranging from 4140 to 36170 in the central subchannel were measured. Various approaches for measurement of wall shear stress were compared. The measurement was performed using the Preston tube technique with the probe outside diameter equal to 0.014 in

  11. Test and lower bound modeling of keyed shear connections in RC shear walls

    DEFF Research Database (Denmark)

    Sørensen, Jesper Harrild; Herfelt, Morten Andersen; Hoang, Linh Cao

    2018-01-01

    This paper presents an investigation into the ultimate behavior of a recently developed design for keyed shear connections. The influence of the key depth on the failure mode and ductility of the connection has been studied by push-off tests. The tests showed that connections with larger key...

  12. Seismic Failure Mechanism of Reinforced Cold-Formed Steel Shear Wall System Based on Structural Vulnerability Analysis

    Directory of Open Access Journals (Sweden)

    Jihong Ye

    2017-02-01

    Full Text Available A series of structural vulnerability analyses are conducted on a reinforced cold-formed steel (RCFS shear wall system and a traditional cold-formed steel (CFS shear wall system subjected to earthquake hazard based on forms in order to investigate their failure mechanisms. The RCFS shear wall adopts rigid beam-column joints and continuous concrete-filled CFS tube end studs rather than coupled-C section end studs that are used in traditional CFS shear walls, to achieve the rigid connections in both beam-column joints and column bases. The results show that: the RCFS and traditional CFS shear wall systems both exhibit the maximum vulnerability index associated with the failure mode in the first story. Therefore, the first story is likely to be a weakness of the CFS shear wall system. Once the wall is damaged, the traditional CFS shear wall system would collapse because the shear wall is the only lateral-resisting component. However, the collapse resistance of the RCFS shear wall system is effectively enhanced by the second defense, which is provided by a framework integrated by rigid beam-column joints and fixed column bases. The predicted collapse mode with maximum vulnerability index that was obtained by structural vulnerability analysis agrees well with the experimental result, and the structural vulnerability method is thereby verified to be reasonable to identify the weaknesses of framed structures and predict their collapse modes. Additionally, the quantitative vulnerability index indicates that the RCFS shear wall system exhibits better robustness compared to the traditional one. Furthermore, the “strong frame weak wallboard” and the “strong column weak beam” are proposed in this study as conceptional designations for the RCFS shear wall systems.

  13. Convection of wall shear stress events in a turbulent boundary layer

    Science.gov (United States)

    Pabon, Rommel; Mills, David; Ukeiley, Lawrence; Sheplak, Mark

    2017-11-01

    The fluctuating wall shear stress is measured in a zero pressure gradient turbulent boundary layer of Reτ 1700 simultaneously with velocity measurements using either hot-wire anemometry or particle image velocimetry. These experiments elucidate the patterns of large scale structures in a single point measurement of the wall shear stress, as well as their convection velocity at the wall. The wall shear stress sensor is a CS-A05 one-dimensional capacitice floating element from Interdisciplinary Consulting Corp. It has a nominal bandwidth from DC to 5 kHz and a floating element size of 1 mm in the principal sensing direction (streamwise) and 0.2 mm in the cross direction (spanwise), allowing the large scales to be well resolved in the current experimental conditions. In addition, a two sensor array of CS-A05 aligned in the spanwise direction with streamwise separations O (δ) is utilized to capture the convection velocity of specific scales of the shear stress through a bandpass filter and peaks in the correlation. Thus, an average wall normal position for the corresponding convecting event can be inferred at least as high as the equivalent local streamwise velocity. This material is based upon work supported by the National Science Foundation Graduate Research Fellowship under Grant No. DGE-1315138.

  14. Simultaneous wall-shear-stress and wide-field PIV measurements in a turbulent boundary layer

    Science.gov (United States)

    Gomit, Guillaume; Fourrie, Gregoire; de Kat, Roeland; Ganapathisubramani, Bharathram

    2015-11-01

    Simultaneous particle image velocimetry (PIV) and hot-film shear stress sensor measurements were performed to study the large-scale structures associated with shear stress events in a flat plate turbulent boundary layer at a high Reynolds number (Reτ ~ 4000). The PIV measurement was performed in a streamwise-wall normal plane using an array of six high resolution cameras (4 ×16MP and 2 ×29MP). The resulting field of view covers 8 δ (where δ is the boundary layer thickness) in the streamwise direction and captures the entire boundary layer in the wall-normal direction. The spatial resolution of the measurement is approximately is approximately 70 wall units (1.8 mm) and sampled each 35 wall units (0.9 mm). In association with the PIV setup, a spanwise array of 10 skin-friction sensors (spanning one δ) was used to capture the footprint of the large-scale structures. This combination of measurements allowed the analysis of the three-dimensional conditional structures in the boundary layer. Particularly, from conditional averages, the 3D organisation of the wall normal and streamwise velocity components (u and v) and the Reynolds shear stress (-u'v') related to a low and high shear stress events can be extracted. European Research Council Grant No-277472-WBT.

  15. Experimental assessment of air permeability in a concrete shear wall subjected to simulated seismic loading

    International Nuclear Information System (INIS)

    Girrens, S.P.; Farrar, C.R.

    1991-07-01

    A safety concern for the proposed Special Nuclear Materials Laboratory (SNML) facility at the Los Alamos National Laboratory was air leakage from the facility if it were to experience a design basis earthquake event. To address this concern, a study was initiated to estimate air leakage, driven by wind-generated pressure gradients, from a seismically damaged concrete structure. This report describes a prototype experiment developed and performed to measure the air permeability in a reinforced concrete shear wall, both before and after simulated seismic loading. A shear wall test structure was fabricated with standard 4000-psi concrete mix. Static load-cycle testing was used to simulate earthquake loading. Permeability measurements were made by pressurizing one side of the shear wall above atmospheric conditions and recording the transient pressure decay. As long as the structure exhibited linear load displacement response, no variation in the air permeability was detected. However, experimental results indicate that the air permeability in the shear wall increased by a factor of 40 after the wall had been damaged (cracked). 17 figs., 8 tabs

  16. Evaluation of carotid vessel wall enhancement with image subtraction after gadobenate dimeglumine-enhanced MR angiography

    International Nuclear Information System (INIS)

    Sardanelli, Francesco; Di Leo, Giovanni; Aliprandi, Alberto; Flor, Nicola; Papini, Giacomo D.E.; Roccatagliata, Luca; Cotticelli, Biagio; Nano, Giovanni; Cornalba, Gianpaolo

    2009-01-01

    Objectives: This study was aimed at testing the value of image subtraction for evaluating carotid vessel wall enhancement in contrast-enhanced MR angiography (MRA). Materials and methods: IRB approval was obtained. The scans of 81 consecutive patients who underwent carotid MRA with 0.1 mmol/kg of gadobenate dimeglumine were reviewed. Axial carotid 3D T1-weighted fast low-angle shot sequence before and 3 min after contrast injection were acquired and subtracted (enhanced minus unenhanced). Vessel wall enhancement was assigned a four-point score using native or subtracted images from 0 (no enhancement) to 3 (strong enhancement). Stenosis degree was graded according to NASCET. Results: With native images, vessel wall enhancement was detected in 20/81 patients (25%) and in 20/161 carotids (12%), and scored 2.0 ± 0.6 (mean ± standard deviation); with subtracted images, in 21/81 (26%) and 22/161 (14%), and scored 2.5 ± 0.6, respectively (P < 0.001, Sign test). The overall stenosis degree distribution was: mild, 41/161 (25%); moderate, 77/161 (48%); severe, 43/161 (27%). Carotids with moderate stenosis showed vessel wall enhancement with a frequency (17/77, 22%) significantly higher than that observed in carotids with mild stenosis (1/41, 2%) (P = 0.005, Fisher exact test) and higher, even though with borderline significance (P = 0.078, Fisher exact test), than that observed in carotids with severe stenosis (4/43, 9%). Conclusion: Roughly a quarter of patients undergoing carotid MRA showed vessel wall enhancement. Image subtraction improved vessel wall enhancement conspicuity. Vessel wall enhancement seems to be an event relatively independent from the degree of stenosis. Further studies are warranted to define the relation between vessel wall enhancement and histopathology, inflammatory status, and instability.

  17. Evaluation of Steel Shear Walls Behavior with Sinusoidal and Trapezoidal Corrugated Plates

    Directory of Open Access Journals (Sweden)

    Emad Hosseinpour

    2015-01-01

    Full Text Available Reinforcement of structures aims to control the input energy of unnatural and natural forces. In the past four decades, steel shear walls are utilized in huge constructions in some seismic countries such as Japan, United States, and Canada to lessen the risk of destructive forces. The steel shear walls are divided into two types: unstiffened and stiffened. In the former, a series of plates (sinusoidal and trapezoidal corrugated with light thickness are used that have the postbuckling field property under overall buckling. In the latter, steel profile belt series are employed as stiffeners with different arrangement: horizontal, vertical, or diagonal in one side or both sides of wall. In the unstiffened walls, increasing the thickness causes an increase in the wall capacity under large forces in tall structures. In the stiffened walls, joining the stiffeners to the wall is costly and time consuming. The ANSYS software was used to analyze the different models of unstiffened one-story steel walls with sinusoidal and trapezoidal corrugated plates under lateral load. The obtained results demonstrated that, in the walls with the same dimensions, the trapezoidal corrugated plates showed higher ductility and ultimate bearing compared to the sinusoidal corrugated plates.

  18. Strength-toughness requirements for thick walled high pressure vessels

    International Nuclear Information System (INIS)

    Kapp, J.A.

    1990-01-01

    The strength and toughness requirements of materials for use in high pressure vessels has been the subject of some discussion in the meetings of the Materials Task Group of the Special Working Group High Pressure Vessels. A fracture mechanics analysis has been performed to theoretically establish the required toughness for a high pressure vessel. This paper reports that the analysis performed is based on the validity requirement for plane strain fracture of fracture toughness test specimens. This is that at the fracture event, the crack length, uncracked ligament, and vessel length must each be greater than fifty times the crack tip plastic zone size for brittle fracture to occur. For high pressure piping applications, the limiting physical dimension is the uncracked ligament, as it can be assumed that the other dimensions are always greater than fifty times the crack tip plastic zone. To perform the fracture mechanics analysis several parameters must be known: these include vessel dimensions, material strength, degree of autofrettage, and design pressure. Results of the analysis show, remarkably, that the effects of radius ratio, pressure and degree of autofrettage can be ignored when establishing strength and toughness requirements for code purposes. The only parameters that enter into the calculation are yield strength, toughness and vessel thickness. The final results can easily be represented as a graph of yield strength against toughness on which several curves, one for each vessel thickness, are plotted

  19. Experimental and theoretical analysis of shear wall failure

    International Nuclear Information System (INIS)

    Gantenbein, F.; Queval, J.C.; Dalbera, J.

    1993-01-01

    Thirteen walls with and without openings have been tested under seismic loading up to collapse and the test results have already been reported. A global model has been developed for the description of the hysteretic behaviour; it is based on the use of secant stiffness up to the steel yielding and on a slip model after yielding. Applications of this model to the walls with and without openings will be shown and the calculated top displacement will be compared with the measured one. The input load level leading to the failure is calculated with this non-linear model and the results are compared with the experimental values. The safety margin, which is defined as the ratio of the experimental load level leading to the failure to that obtained by linear calculation, will be given as a function of the mean excitation frequency

  20. Impact of competitive flow on wall shear stress in coronary surgery: computational fluid dynamics of a LIMA-LAD model.

    Science.gov (United States)

    Nordgaard, Håvard; Swillens, Abigail; Nordhaug, Dag; Kirkeby-Garstad, Idar; Van Loo, Denis; Vitale, Nicola; Segers, Patrick; Haaverstad, Rune; Lovstakken, Lasse

    2010-12-01

    Competitive flow from native coronary vessels is considered a major factor in the failure of coronary bypass grafts. However, the pathophysiological effects are not fully understood. Low and oscillatory wall shear stress (WSS) is known to induce endothelial dysfunction and vascular disease, like atherosclerosis and intimal hyperplasia. The aim was to investigate the impact of competitive flow on WSS in mammary artery bypass grafts. Using computational fluid dynamics, WSS was calculated in a left internal mammary artery (LIMA) graft to the left anterior descending artery in a three-dimensional in vivo porcine coronary artery bypass graft model. The following conditions were investigated: high competitive flow (non-significant coronary lesion), partial competitive flow (significant coronary lesion), and no competitive flow (totally occluded coronary vessel). Time-averaged WSS of LIMA at high, partial, and no competitive flow were 0.3-0.6, 0.6-3.0, and 0.9-3.0 Pa, respectively. Further, oscillatory WSS quantified as the oscillatory shear index (OSI) ranged from (maximum OSI = 0.5 equals zero net WSS) 0.15 to 0.35, OSI similar to the no competitive flow condition. Graft flow is highly dependent on the degree of competitive flow. High competitive flow was found to produce unfavourable WSS consistent with endothelial dysfunction and subsequent graft narrowing and failure. Partial competitive flow, however, may be better tolerated as it was found to be similar to the ideal condition of no competitive flow.

  1. Development of generalized correlation equation for the local wall shear stress

    International Nuclear Information System (INIS)

    Jeon, Yu Mi; Bae, Jun Ho; Park, Joo Hwan

    2010-01-01

    The pressure drop characteristics for a fuel channel are essential for the design and reliable operation of a nuclear reactor. Over several decades, analytical methods have been developed to predict the friction factor in the fuel bundle flows. In order to enhance the accuracy of prediction for the pressure drop in a rod bundle, the influences of a channel wall and the local shear stress distribution should be considered. Hence, the correlation equation for a local shear stress distribution should be developed in order to secure an analytical solution for the friction factor of a rod bundle. For a side subchannel, which has the influence of the channel wall, the local shear stress distribution is dependent on the ratio of wall to diameter (W/D) as well as the ratio of pitch to diameter (P/D). In the case that W/D has the same value with P/D, the local shear stress distribution can be simply correlated with the function of angular position for each value of P/D. While, in the case that W/D has the different value with P/D, the correlation equation should be developed for each case of P/D and W/D. Hence, in the present study, the generalized correlation equation of a local shear stress distribution is developed for a side subchannel in the case that W/D has the different value with P/D

  2. Design of squat shear walls using continuous strut-and-tie resistant models

    International Nuclear Information System (INIS)

    Santos, S.H. de C; Silva, R.E. da

    1993-01-01

    A new approach is presented for designing squat shear walls, subjected to seismic loading. In this approach, the strut-and-tie resistant models, proposed by Schlaich et al., are generalized in order to analyze continuous fields of compression and tension stresses. The application of the presented methodology is illustrated through numerical examples. (author)

  3. Volumetric Arterial Wall Shear Stress Calculation Based on Cine Phase Contrast MRI

    NARCIS (Netherlands)

    Potters, Wouter V.; van Ooij, Pim; Marquering, Henk; VanBavel, Ed; Nederveen, Aart J.

    2015-01-01

    PurposeTo assess the accuracy and precision of a volumetric wall shear stress (WSS) calculation method applied to cine phase contrast magnetic resonance imaging (PC-MRI) data. Materials and MethodsVolumetric WSS vectors were calculated in software phantoms. WSS algorithm parameters were optimized

  4. Modelling Force Transfer Around Openings of Full-Scale Shear Walls

    Science.gov (United States)

    Tom Skaggs; Borjen Yeh; Frank Lam; Minghao Li; Doug Rammer; James Wacker

    2011-01-01

    Wood structural panel (WSP) sheathed shear walls and diaphragms are the primary lateralload-resisting elements in wood-frame construction. The historical performance of lightframe structures in North America has been very good due, in part, to model building codes that are designed to preserve life safety. These model building codes have spawned continual improvement...

  5. Full-scale shear wall tests for force transfer around openings

    Science.gov (United States)

    Tom Skaggs; Borjen Yeh; Frank Lam; Douglas Rammer; James Wacker

    2010-01-01

    Wood structural panel sheathed shear walls and diaphragms are the primary lateral-load resisting elements in wood-frame construction. The historical performance of light-frame structures in North America are very good due, in part, to model building codes that are designed to preserve life safety, as well as the inherent redundancy of wood-frame construction using wood...

  6. Augmentation of wall shear stress inhibits neointimal hyperplasia after stent implantation - Inhibition through reduction of inflammation?

    NARCIS (Netherlands)

    Carlier, SG; van Damme, LCA; Blommerde, CP; Wentzel, JJ; van Langehove, G; Verheye, S; Kockx, MM; Knaapen, MWM; Cheng, C; Gijsen, F; Duncker, DJ; Stergiopulos, N; Slager, CJ; Serruys, PW; Krams, R

    2003-01-01

    Background - Low wall shear stress (WSS) increases neointimal hyperplasia (NH) in vein grafts and stents. We studied the causal relationship between WSS and NH formation in stents by locally increasing WSS with a flow divider (Anti-Restenotic Diffuser, Endoart SA) placed in the center of the stent.

  7. Wall shear stress from a rotating cylinder in cross flow using the electrochemical technique

    International Nuclear Information System (INIS)

    Labraga, L.; Bourabaa, N.; Berkah, T.

    2002-01-01

    The wall shear rate from a rotating cylinder in a uniform flow was measured with flush-mounted electrochemical mass transfer probes. The experiments were performed using two rectangular electrodes in a sandwich arrangement. Initially, the frequency response of that probe was numerically studied using an inverse mass transfer method in order to restore the whole wall shear stress in the time domain starting from the measured transfer coefficients given by the split probe. The experiments were performed in the range of velocity ratios 0 4, points of zero shear stress on the rotating cylinder vanish, which is in fact consistent with the previous arguments that the cylinder is surrounded by a set of closed streamlines. This experimental study shows that, when their dynamic behaviour is known, the electrochemical probes are able to sense complex fine structures not observed up to now by previous analytical, numerical or experimental methods, even when non-linear effects are not negligible. (orig.)

  8. Load carrying capacity of shear wall t-connections reinforced with high strength wire ropes

    DEFF Research Database (Denmark)

    Jørgensen, Henrik B.; Bryndom, Thor; Larsen, Michael

    2016-01-01

    -friendly solution. The wire ropes have no bending stiffness and therefore allow for an easier vertical installation of the wall elements. During the last 10 – 15 years, a number of shear tests on plane wire rope connections have been carried out. However, to the best knowledge of the authors, tests on wire rope......Traditionally, U-bar loop connections with keyed joints have been used in vertical shear connections between precast concrete wall elements. However, in the recent years, connections with looped high strength wire ropes instead of U-bar loops have proven to be a much more construction...... connections for assembly of precast elements in different planes, such as T- and L-connections, have not yet been published. This paper presents the results of a large test series recently conducted at the University of Southern Denmark to study the shear behaviour of high strength wire rope T...

  9. Test on the splitting failure capacity of the bottom rail due to uplift in partially anchored shear walls

    OpenAIRE

    Caprolu, Giuseppe; Girhammar, Ulf Arne; Källsner, Bo; Johnsson, Helena

    2012-01-01

    Källsner and Girhammar have developed a new plastic design method for wood-frame shear walls at ultimate limit state. The method is capable of calculating the load-carrying capacity of partially anchored shear walls, where the leading stud is not necessarily anchored against uplift. In fully anchored shear walls, the leading stud needs to be anchored using some kind of hold-downs to resist uplift and the bottom rail needs to be fixed by anchor bolts to resist horizontal shear forces. In parti...

  10. Literature Review of Shear Performance of Light-weight Steel Framing Wall Panels

    Science.gov (United States)

    Zhang, Zhuangnan; Liu, Shen; Liu, Hong

    2018-03-01

    In this paper, a comprehensive review of light-weight steel framing wall panels was carried out. The structure and force characteristics of light-weight steel framing wall panels were introduced. The testing and theoretical research results on the shear behaviour of light-weight steel framing wall panels were summarized in the domestic and foreign. And combined with the existing standards in China, the author's views and ideas are put forward to the problems in the research field of this kind of structural system.

  11. Simulation of Diffusive Lithium Evaporation Onto the NSTX Vessel Walls

    International Nuclear Information System (INIS)

    Stotler, D.P.; Skinner, C.H.; Blanchard, W.R.; Krstic, P.S.; Kugel, H.W.; Schneider, H.; Zakharov, L.E.

    2010-01-01

    A model for simulating the diffusive evaporation of lithium into a helium filled NSTX vacuum vessel is described and validated against an initial set of deposition experiments. The DEGAS 2 based model consists of a three-dimensional representation of the vacuum vessel, the elastic scattering process, and a kinetic description of the evaporated atoms. Additional assumptions are required to account for deuterium out-gassing during the validation experiments. The model agrees with the data over a range of pressures to within the estimated uncertainties. Suggestions are made for more discriminating experiments that will lead to an improved model.

  12. Statistics on Near Wall Structures and Shear Stress Distribution from 3D Holographic Measurement.

    Science.gov (United States)

    Sheng, J.; Malkiel, E.; Katz, J.

    2007-11-01

    Digital Holographic Microscopy performs 3D velocity measurement in the near-wall region of a turbulent boundary layer in a square channel over a smooth wall at Reτ=1,400. Resolution of ˜1μm over a sample volume of 1.5x2x1.5mm (x^+=50, y^+=60, z^+=50) is sufficient for resolving buffer layer and lower log layer structures, and for measuring instantaneous wall shear stress distributions from velocity gradients in the viscous sublayer. Results, based on 700 instantaneous realizations, provide detailed statistics on the spatial distribution of both wall stress components along with characteristic flow structures. Conditional sampling based on maxima and minima of wall shear stresses, as well as examination of instantaneous flow structures, lead to development of a conceptual model for a characteristic flow phenomenon that seems to generating extreme stress events. This structure develops as an initially spanwise vortex element rises away from the surface, due to local disturbance, causing a local stress minimum. Due to increasing velocity with elevation, this element bends downstream, forming a pair of inclined streamwise vortices, aligned at 45^0 to freestream, with ejection-like flow between them. Entrainment of high streamwise momentum on the outer sides of this vortex pair generates streamwise shear stress maxima, 70 δν downstream, which are displaced laterally by 35 δν from the local minimum.

  13. Bayesian decision and mixture models for AE monitoring of steel-concrete composite shear walls

    Science.gov (United States)

    Farhidzadeh, Alireza; Epackachi, Siamak; Salamone, Salvatore; Whittaker, Andrew S.

    2015-11-01

    This paper presents an approach based on an acoustic emission technique for the health monitoring of steel-concrete (SC) composite shear walls. SC composite walls consist of plain (unreinforced) concrete sandwiched between steel faceplates. Although the use of SC system construction has been studied extensively for nearly 20 years, little-to-no attention has been devoted to the development of structural health monitoring techniques for the inspection of damage of the concrete behind the steel plates. In this work an unsupervised pattern recognition algorithm based on probability theory is proposed to assess the soundness of the concrete infill, and eventually provide a diagnosis of the SC wall’s health. The approach is validated through an experimental study on a large-scale SC shear wall subjected to a displacement controlled reversed cyclic loading.

  14. Experimental and Numerical Analyses of New Massive Wooden Shear-Wall Systems

    Directory of Open Access Journals (Sweden)

    Luca Pozza

    2014-07-01

    Full Text Available Three innovative massive wooden shear-wall systems (Cross-Laminated-Glued Wall, Cross-Laminated-Stapled Wall, Layered Wall with dovetail inserts were tested and their structural behaviour under seismic action was assessed with numerical simulations. The wall specimens differ mainly in the method used to assemble the layers of timber boards composing them. Quasi-static cyclic loading tests were carried out and then reproduced with a non-linear numerical model calibrated on the test results to estimate the most appropriate behaviour factor for each system. Non-linear dynamic simulations of 15 artificially generated seismic shocks showed that these systems have good dissipative capacity when correctly designed and that they can be assigned to the medium ductility class of Eurocode 8. This work also shows the influence of deformations in wooden panels and base connectors on the behaviour factor and dissipative capacity of the system.

  15. The Effect of Displacement Mode of Rigid Retaining Walls on Shearing Bands by Active Earth Pressure

    Directory of Open Access Journals (Sweden)

    A. Sekkel

    2013-10-01

    Full Text Available This work treats the physical modeling of failure mechanisms by active earth pressure. This last is developed by retaining wall movement. A lot of research showed that wall displacement has a significant effect on active earth pressure. A good comprehension of active earth pressure phenomenon and its failure mechanisms help us to better conceive retaining walls. The conception of a small-scale model allowed the realization of active earth pressure tests, while displacing the mobile wall toward the outside of the massif. The studied material is that of Schneebeli; light two-dimensional material made of cylindrical plastic rollers, simulating granular non-cohesive soil. The evolution of shearing zones under continuous and discontinuous displacement modes of mobile walls by correlation pictures allows the investigation of the localization of deformations and failure mechanisms.

  16. Measurements of wall-shear-stress distribution on an NACA0018 airfoil by liquid-crystal coating and near-wall particle image velocimetry (PIV)

    International Nuclear Information System (INIS)

    Fujisawa, N; Oguma, Y; Nakano, T

    2009-01-01

    Measurements of wall-shear-stress distributions along curved surfaces are carried out using non-intrusive experimental methods, such as liquid-crystal coating and near-wall particle image velocimetry (PIV). The former method relies on the color change of the liquid-crystal coating sensitive to the wall shear stress, while the latter is based on the direct evaluation of shear stresses through the near-wall PIV measurement in combination with the image deformation technique. These experimental methods are applied to the measurement of wall-shear-stress distributions of air flow at a free-stream velocity of 15 m s −1 on a flat plate and an NACA0018 airfoil. The experiments are carried out at zero angle of attack for the flat plate and at 0° and ±6° angles of attack for the airfoil, and then the variations of shear-stress distribution along these surfaces are studied. These measurements in wall shear stresses agree with each other within their experimental uncertainties, suggesting the validity of experimental methods for non-intrusive shear-stress measurements. It is found that the wall-shear-stress distribution shows a small negative value upstream of the reattachment point on the NACA0018 airfoil, which is followed by an increase in shear stresses downstream due to laminar–turbulent transition of boundary layers. Such behavior of wall-shear-stress distribution is well correlated with the mean flow and turbulence characteristics along the airfoil surfaces, which are measured by PIV

  17. Load Carrying Capacity of Shear Wall T-Connections Reinforced with High Strength Wire Ropes

    DEFF Research Database (Denmark)

    Jørgensen, Henrik Brøner; Bryndum, Thor; Larsen, Michael

    2017-01-01

    Traditionally, U-bar loop connections with keyed joints have been used in vertical shear connections between precast concrete wall elements. However, in the recent years, connections with looped high strength wire ropes instead of U-bar loops have proven to be a much more construction-friendly so......Traditionally, U-bar loop connections with keyed joints have been used in vertical shear connections between precast concrete wall elements. However, in the recent years, connections with looped high strength wire ropes instead of U-bar loops have proven to be a much more construction......-friendly solution. The wire ropes have no bending stiffness and therefore allow for an easier vertical installation of the wall elements. During the last 10 – 15 years, a number of shear tests on plane wire rope connections have been carried out. However, to the best knowledge of the authors, tests on wire rope...... connections for assembly of precast elements in different planes, such as T- and L-connections, have not yet been published. This paper presents the results of a large test series recently conducted at the University of Southern Denmark to study the shear behaviour of high strength wire rope T...

  18. Proteomic profiling of tissue-engineered blood vessel walls constructed by adipose-derived stem cells.

    Science.gov (United States)

    Wang, Chen; Guo, Fangfang; Zhou, Heng; Zhang, Yun; Xiao, Zhigang; Cui, Lei

    2013-02-01

    Adipose-derived stem cells (ASCs) can differentiate into smooth muscle cells and have been engineered into elastic small diameter blood vessel walls in vitro. However, the mechanisms involved in the development of three-dimensional (3D) vascular tissue remain poorly understood. The present study analyzed protein expression profiles of engineered blood vessel walls constructed by human ASCs using methods of two-dimensional gel electrophoresis (2DE) and mass spectrometry (MS). These results were compared to normal arterial walls. A total of 1701±15 and 1265±26 protein spots from normal and engineered blood vessel wall extractions were detected by 2DE, respectively. A total of 20 spots with at least 2.0-fold changes in expression were identified, and 38 differently expressed proteins were identified by 2D electrophoresis and ion trap MS. These proteins were classified into seven functional categories: cellular organization, energy, signaling pathway, enzyme, anchored protein, cell apoptosis/defense, and others. These results demonstrated that 2DE, followed by ion trap MS, could be successfully utilized to characterize the proteome of vascular tissue, including tissue-engineered vessels. The method could also be employed to achieve a better understanding of differentiated smooth muscle protein expression in vitro. These results provide a basis for comparative studies of protein expression in vascular smooth muscles of different origin and could provide a better understanding of the mechanisms of action needed for constructing blood vessels that exhibit properties consistent with normal blood vessels.

  19. Direct measurement of wall shear stress in a reattaching flow with a photonic sensor

    International Nuclear Information System (INIS)

    Ayaz, U K; Ioppolo, T; Ötügen, M V

    2013-01-01

    Wall shear stress measurements are carried out in a planar backward-facing step flow using a micro-optical sensor. The sensor is essentially a floating element system and measures the shear stress directly. The transduction method to measure the floating element deflection is based on the whispering gallery optical mode (WGM) shifts of a dielectric microsphere. This method is capable of measuring floating element displacements of the order of a nanometer. The floating element surface is circular with a diameter of ∼960 µm, which is part of a beam that is in contact with the dielectric microsphere. The sensor is calibrated for shear stress as well as pressure sensitivity yielding 7.3 pm Pa −1 and 0.0236 pm Pa −1 for shear stress and pressure sensitivity, respectively. Hence, the contribution by the wall pressure is less than two orders of magnitude smaller than that of shear stress. Measurements are made for a Reynolds number range of 2000–5000 extending to 18 step heights from the step face. The results are in good agreement with those of earlier reports. An analysis is also carried out to evaluate the performance of the WGM sensor including measurement sensitivity and bandwidth. (paper)

  20. Pressure vessel rupture within a chamber: the pressure history on the chamber wall

    International Nuclear Information System (INIS)

    Baum, M.R.

    1989-04-01

    Generally there is a large number of pressure vessels containing high pressure gas on power stations and chemical plant. In many instances, particularly on power plant, these vessels are within the main building. If a pressure vessel were to fail, the surrounding structures would be exposed to blast loads and the forces resulting from jets of fluid issuing from the breached vessel. In the case where the vessel is in a relatively closed chamber there would also be a general overpressurisation of the chamber. At the design stage it is therefore essential to demonstrate that the plant could be safely shut down in the event of a pressure vessel failure, that is, it must be shown that the chamber will not collapse thus putting the building at risk or hazarding equipment essential for a safe shut down. Such an assessment requires the loads applied to the chamber walls, roof, etc. to be known. (author)

  1. Beam model for seismic analysis of complex shear wall structure based on the strain energy equivalence

    International Nuclear Information System (INIS)

    Reddy, G.R.; Mahajan, S.C.; Suzuki, Kohei

    1997-01-01

    A nuclear reactor building structure consists of shear walls with complex geometry, beams and columns. The complexity of the structure is explained in the section Introduction. Seismic analysis of the complex reactor building structure using the continuum mechanics approach may produce good results but this method is very difficult to apply. Hence, the finite element approach is found to be an useful technique for solving the dynamic equations of the reactor building structure. In this approach, the model which uses finite elements such as brick, plate and shell elements may produce accurate results. However, this model also poses some difficulties which are explained in the section Modeling Techniques. Therefore, seismic analysis of complex structures is generally carried out using a lumped mass beam model. This model is preferred because of its simplicity and economy. Nevertheless, mathematical modeling of a shear wall structure as a beam requires specialized skill and a thorough understanding of the structure. For accurate seismic analysis, it is necessary to model more realistically the stiffness, mass and damping. In linear seismic analysis, modeling of the mass and damping may pose few problems compared to modeling the stiffness. When used to represent a complex structure, the stiffness of the beam is directly related to the shear wall section properties such as area, shear area and moment of inertia. Various beam models which are classified based on the method of stiffness evaluation are also explained under the section Modeling Techniques. In the section Case Studies the accuracy and simplicity of the beam models are explained. Among various beam models, the one which evaluates the stiffness using strain energy equivalence proves to be the simplest and most accurate method for modeling the complex shear wall structure. (author)

  2. Numerical Analysis of Carbon Fiber Reinforced Plastic (CFRP) Shear Walls and Steel Strips under Cyclic Loads Using Finite Element Method

    OpenAIRE

    Askarizadeh, N.; Mohammadizadeh, M. R.

    2017-01-01

    Reinforced concrete shear walls are the main elements of resistance against lateral loads in reinforced concrete structures. These walls should not only provide sufficient resistance but also provide sufficient ductility in order to avoid brittle fracture, particularly under strong seismic loads. However, many reinforced concrete shear walls need to be stabilized and reinforced due to various reasons such as changes in requirements of seismic regulations, weaknesses in design and execution, p...

  3. Segmentation of arterial vessel wall motion to sub-pixel resolution using M-mode ultrasound.

    Science.gov (United States)

    Fancourt, Craig; Azer, Karim; Ramcharan, Sharmilee L; Bunzel, Michelle; Cambell, Barry R; Sachs, Jeffrey R; Walker, Matthew

    2008-01-01

    We describe a method for segmenting arterial vessel wall motion to sub-pixel resolution, using the returns from M-mode ultrasound. The technique involves measuring the spatial offset between all pairs of scans from their cross-correlation, converting the spatial offsets to relative wall motion through a global optimization, and finally translating from relative to absolute wall motion by interpolation over the M-mode image. The resulting detailed wall distension waveform has the potential to enhance existing vascular biomarkers, such as strain and compliance, as well as enable new ones.

  4. Shear Tests and Calculation of Shear Resistance with the PC Program RFEM from Thin Partition Walls of Brick in Old Buildings

    Directory of Open Access Journals (Sweden)

    Korjenic Sinan

    2015-11-01

    Full Text Available This paper is about the shear capacity of partition walls in old buildings based on shear tests which were carried out under real conditions in an existing building. There were experiments conducted on different floors and in each case, the maximum recordable horizontal force and the horizontal displacement of the respective mortar were measured. At the same time material studies and material investigations were carried out in the laboratory. The material parameters were used for the calculation of the precise shear capacity of each joint. In the shear tests, the maximum displacement of a mortar joint was determined at a maximum of two to four millimetres. Furthermore, no direct linear relationship between the theoretical load (wall above it and the shear stress occurred could be detected in the analysis of the experiment, as it was previously assumed.

  5. Shear Tests and Calculation of Shear Resistance with the PC Program RFEM from Thin Partition Walls of Brick in Old Buildings

    Science.gov (United States)

    Korjenic, Sinan; Nowak, Bernhard; Löffler, Philipp; Vašková, Anna

    2015-11-01

    This paper is about the shear capacity of partition walls in old buildings based on shear tests which were carried out under real conditions in an existing building. There were experiments conducted on different floors and in each case, the maximum recordable horizontal force and the horizontal displacement of the respective mortar were measured. At the same time material studies and material investigations were carried out in the laboratory. The material parameters were used for the calculation of the precise shear capacity of each joint. In the shear tests, the maximum displacement of a mortar joint was determined at a maximum of two to four millimetres. Furthermore, no direct linear relationship between the theoretical load (wall above it) and the shear stress occurred could be detected in the analysis of the experiment, as it was previously assumed.

  6. Two Complementary Mechanisms Underpin Cell Wall Patterning during Xylem Vessel Development.

    Science.gov (United States)

    Schneider, Rene; Tang, Lu; Lampugnani, Edwin R; Barkwill, Sarah; Lathe, Rahul; Zhang, Yi; McFarlane, Heather E; Pesquet, Edouard; Niittyla, Totte; Mansfield, Shawn D; Zhou, Yihua; Persson, Staffan

    2017-10-01

    The evolution of the plant vasculature was essential for the emergence of terrestrial life. Xylem vessels are solute-transporting elements in the vasculature that possess secondary wall thickenings deposited in intricate patterns. Evenly dispersed microtubule (MT) bands support the formation of these wall thickenings, but how the MTs direct cell wall synthesis during this process remains largely unknown. Cellulose is the major secondary wall constituent and is synthesized by plasma membrane-localized cellulose synthases (CesAs) whose catalytic activity propels them through the membrane. We show that the protein CELLULOSE SYNTHASE INTERACTING1 (CSI1)/POM2 is necessary to align the secondary wall CesAs and MTs during the initial phase of xylem vessel development in Arabidopsis thaliana and rice ( Oryza sativa ). Surprisingly, these MT-driven patterns successively become imprinted and sufficient to sustain the continued progression of wall thickening in the absence of MTs and CSI1/POM2 function. Hence, two complementary principles underpin wall patterning during xylem vessel development. © 2017 American Society of Plant Biologists. All rights reserved.

  7. High-resolution intracranial vessel wall MRI in an elderly asymptomatic population: comparison of 3T and 7T

    Energy Technology Data Exchange (ETDEWEB)

    Harteveld, Anita A.; Kolk, Anja G. van der; Dieleman, Nikki; Siero, Jeroen C.W.; Luijten, Peter R.; Zwanenburg, Jaco J.M.; Hendrikse, Jeroen [University Medical Center Utrecht, Department of Radiology, Postbox 85500, Utrecht (Netherlands); Worp, H.B. van der; Frijns, Catharina J.M. [University Medical Center Utrecht, Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, Utrecht (Netherlands); Kuijf, Hugo J. [University Medical Center Utrecht, Image Sciences Institute, Utrecht (Netherlands)

    2017-04-15

    Several intracranial vessel wall sequences have been described in recent literature, with either 3-T or 7-T magnetic resonance imaging (MRI). In the current study, we compared 3-T and 7-T MRI in visualising both the intracranial arterial vessel wall and vessel wall lesions. Twenty-one elderly asymptomatic volunteers were scanned by 3-T and 7-T MRI with an intracranial vessel wall sequence, both before and after contrast administration. Two raters scored image quality, and presence and characteristics of vessel wall lesions. Vessel wall visibility was equal or significantly better at 7 T for the studied arterial segments, even though there were more artefacts hampering assessment. The better visualisation of the vessel wall at 7 T was most prominent in the proximal anterior cerebral circulation and the posterior cerebral artery. In the studied elderly asymptomatic population, 48 vessel-wall lesions were identified at 3 T, of which 7 showed enhancement. At 7 T, 79 lesions were identified, of which 29 showed enhancement. Seventy-one percent of all 3-T lesions and 59 % of all 7-T lesions were also seen at the other field strength. Despite the large variability in detected lesions at both field strengths, we believe 7-T MRI has the highest potential to identify the total burden of intracranial vessel wall lesions. (orig.)

  8. An experimental investigation of the seismic behavior of semi-supported steel shear walls

    DEFF Research Database (Denmark)

    Jahanpour, Alireza; Jönsson, Jeppe; Moharrami, H.

    2010-01-01

    . These half scale models represent an intermediate storey in a multi-storey steel frame. Hysteresis loops traced from the load deflection curves of these tests have an “S” shape and dissipate energy well. The system has an acceptable level of ductility, which enables its use as a lateral earthquake load......A semi-supported steel shear wall (SSSW) has been developed in the recent decade, the steel wall is connected to secondary columns that do not carry vertical loads and are used to enable the plate to enter into the post buckling region and develop a tension field. Theoretical research...

  9. Research Status on Reinforcement Connection Form of Precast Concrete Shear Wall Structure

    Science.gov (United States)

    Zhang, Zhuangnan; Zhang, Yan

    2018-03-01

    With the rapid development of Chinese economy and the speeding up the process of urbanization, housing industrialization has been paid more and more attention. And the fabricated structure has been widely used in China. The key of precast concrete shear wall structure is the connection of precast components. The reinforcement connection can directly affect the entirety performance and seismic behavior of the structure. Different reinforcement connections have a great impact on the overall behavior of the structure. By studying the characteristics of the reinforcement connection forms used in the vertical connection and horizontal connection of precast concrete shear wall, it can provide reference for the research and development of the reinforcement connection forms in the future.

  10. Steel Plate Shear Walls: Efficient Structural Solution for Slender High-Rise in China

    International Nuclear Information System (INIS)

    Mathias, Neville; Long, Eric; Sarkisian, Mark; Huang Zhihui

    2008-01-01

    The 329.6 meter tall 74-story Jinta Tower in Tianjin, China, is expected, when complete, to be the tallest building in the world with slender steel plate shear walls used as the primary lateral load resisting system. The tower has an overall aspect ratio close to 1:8, and the main design challenge was to develop an efficient lateral system capable of resisting significant wind and seismic lateral loads, while simultaneously keeping wind induced oscillations under acceptable perception limits. This paper describes the process of selection of steel plate shear walls as the structural system, and presents the design philosophy, criteria and procedures that were arrived at by integrating the relevant requirements and recommendations of US and Chinese codes and standards, and current on-going research

  11. Orbitally shaken shallow fluid layers. II. An improved wall shear stress model

    Science.gov (United States)

    Alpresa, Paola; Sherwin, Spencer; Weinberg, Peter; van Reeuwijk, Maarten

    2018-03-01

    A new model for the analytical prediction of wall shear stress distributions at the base of orbitally shaken shallow fluid layers is developed. This model is a generalisation of the classical extended Stokes solution and will be referred to as the potential theory-Stokes model. The model is validated using a large set of numerical simulations covering a wide range of flow regimes representative of those used in laboratory experiments. It is demonstrated that the model is in much better agreement with the simulation data than the classical Stokes solution, improving the prediction in 63% of the studied cases. The central assumption of the model—which is to link the wall shear stress with the surface velocity—is shown to hold remarkably well over all regimes covered.

  12. Lateral stiffness and vibration characteristics of composite plated RC shear walls with variable fibres spacing

    International Nuclear Information System (INIS)

    Meftah, S.A.; Yeghnem, R.; Tounsi, A.; Adda Bedia, E.A.

    2008-01-01

    In this paper, a finite element model for static and free vibration analysis of reinforced concrete (RC) shear walls structures strengthened with thin composite plates having variable fibres spacing is presented. An efficient analysis method that can be used regardless to the sizes and location of the bonded plates is proposed in this study. In the numerical formulation, the adherents and the adhesives are all modelled as shear wall elements, using the mixed finite element method. Several test problems are examined to demonstrate the accuracy and effectiveness of the proposed method. Numerical results are obtained for six nonuniform distributions of E-glass, graphite and boron fibres in epoxy matrices. The fibre redistributions of the bonded plates are seen to increase the frequencies modes and reduce substantially the lateral displacements

  13. Exercise-mediated wall shear stress increases mitochondrial biogenesis in vascular endothelium.

    Directory of Open Access Journals (Sweden)

    Boa Kim

    Full Text Available Enhancing structural and functional integrity of mitochondria is an emerging therapeutic option against endothelial dysfunction. In this study, we sought to investigate the effect of fluid shear stress on mitochondrial biogenesis and mitochondrial respiratory function in endothelial cells (ECs using in vitro and in vivo complementary studies.Human aortic- or umbilical vein-derived ECs were exposed to laminar shear stress (20 dyne/cm2 for various durations using a cone-and-plate shear apparatus. We observed significant increases in the expression of key genes related to mitochondrial biogenesis and mitochondrial quality control as well as mtDNA content and mitochondrial mass under the shear stress conditions. Mitochondrial respiratory function was enhanced when cells were intermittently exposed to laminar shear stress for 72 hrs. Also, shear-exposed cells showed diminished glycolysis and decreased mitochondrial membrane potential (ΔΨm. Likewise, in in vivo experiments, mice that were subjected to a voluntary wheel running exercise for 5 weeks showed significantly higher mitochondrial content determined by en face staining in the conduit (greater and lesser curvature of the aortic arch and thoracic aorta and muscle feed (femoral artery arteries compared to the sedentary control mice. Interestingly, however, the mitochondrial biogenesis was not observed in the mesenteric artery. This region-specific adaptation is likely due to the differential blood flow redistribution during exercise in the different vessel beds.Taken together, our findings suggest that exercise enhances mitochondrial biogenesis in vascular endothelium through a shear stress-dependent mechanism. Our findings may suggest a novel mitochondrial pathway by which a chronic exercise may be beneficial for vascular function.

  14. The Effects of Single-Wall Carbon Nanotubes on the Shear Piezoelectricity of Biopolymers

    Science.gov (United States)

    Lovell, Conrad; Fitz-Gerald, James M.; Harrison, Joycelyn S.; Park, Cheol

    2008-01-01

    Shear piezoelectricity was investigated in a series of composites consisting of increased loadings of single-wall carbon nanotubes (SWCNTs) in poly (gamma-benzyl-L-glutamate), or PBLG. The effects of the SWCNTs on this material property in PBLG will be discussed. Their influence on the morphology of the polymer (degree of orientation and crystallinity), and electrical and dielectric properties of the composite will be reported

  15. Investigation of the Behavior of Steel Shear Walls Using Finite Elements Analysis

    OpenAIRE

    Abubakri, K.; Veladi, H.

    2016-01-01

    Currently, steel shear walls are considered by engineers as an economic method against lateral loads imposed by wind and earthquake in tall structures. Accordingly, there is a growing need to develop accurate methods alongside approximation methods to estimate the behavior of these structural elements. The finite element technique is one of the strongest numerical methods in analysis of solid mechanics problems. Finite element analysis however requires high technical knowledge of the behavior...

  16. Estimation of gas wall shear stress in horizontal stratified gas-liquid pipe flow

    International Nuclear Information System (INIS)

    Newton, C.H.; Behnia, M.

    1996-01-01

    Two-phase pipe flows occur in many industrial applications, such as condensers and evaporators, chemical processing equipment, nuclear reactors, and oil pipelines. A variety of basic mechanistic flow models for predicting the pressure gradient and liquid loading characteristics of these types of flows to assist in design calculations has emerged over the past two decades, especially for the stratified and slug flow regimes. These models generally rely on a number of basic assumptions and empirical closure equations. Possibly the most notable of these relates to the evaluation of interfacial shear stresses. However, one of the most important yet least discussed assumptions used in most of these models is that the phase wall shear stresses can be accurately estimated from correlations developed for single-phase pipe flows. The object of this article is to present measurements of gas wall shear up to locations in close proximity to the gas-liquid interface for a variety of interface conditions in developed flow, and to determine the effects of the interface on average gas wall friction factors. In this context the interface may be smooth, rippled or wavy

  17. Coronary magnetic resonance imaging: visualization of the vessel lumen and the vessel wall and molecular imaging of arteriothrombosis

    International Nuclear Information System (INIS)

    Spuentrup, Elmar; Botnar, Rene M.

    2006-01-01

    Coronary magnetic resonance (MR) imaging has dramatically emerged over the last decade. Technical improvements have enabled reliable visualization of the proximal and midportion of the coronary artery tree for exclusion of significant coronary artery disease. However, current technical developments focus also on direct visualization of the diseased coronary vessel wall and imaging of coronary plaque because plaques without stenoses are typically more vulnerable with higher risk of plaque rupture. Plaque rupture with subsequent thrombosis and vessel occlusion is the main cause of myocardial infarction. Very recently, the first success of molecular imaging in the coronary arteries has been demonstrated using a fibrin-specific contrast agent for selective visualization of coronary thrombosis. This demonstrates in general the high potential of molecular MR imaging in the field of coronary artery disease. In this review, we will address recent technical advances in coronary MR imaging, including visualization of the lumen and the vessel wall and molecular imaging of coronary arteriothrombosis. First results of these new approaches will be discussed. (orig.)

  18. Impact of Age and Aerobic Exercise Training on Conduit Artery Wall Thickness: Role of the Shear Pattern.

    Science.gov (United States)

    Tanahashi, Koichiro; Kosaki, Keisei; Sawano, Yuriko; Yoshikawa, Toru; Tagawa, Kaname; Kumagai, Hiroshi; Akazawa, Nobuhiko; Maeda, Seiji

    2017-01-01

    Hemodynamic shear stress is the frictional force of blood on the arterial wall. The shear pattern in the conduit artery affects the endothelium and may participate in the development and progression of atherosclerosis. We investigated the role of the shear pattern in age- and aerobic exercise-induced changes in conduit artery wall thickness via cross-sectional and interventional studies. In a cross-sectional study, we found that brachial shear rate patterns and brachial artery intima-media thickness (IMT) correlated with age. Additionally, brachial artery shear rate patterns were associated with brachial artery IMT in 102 middle-aged and older individuals. In an interventional study, 39 middle-aged and older subjects were divided into 2 groups: control and exercise. The exercise group completed 12 weeks of aerobic exercise training. Aerobic exercise training significantly increased the antegrade shear rate and decreased the retrograde shear rate and brachial artery IMT. Moreover, changes in the brachial artery antegrade shear rate and the retrograde shear rate correlated with the change in brachial artery IMT. The results of the present study indicate that changes in brachial artery shear rate patterns may contribute to age- and aerobic exercise training-induced changes in brachial artery wall thickness. © 2017 S. Karger AG, Basel.

  19. Resistive instabilities in reversed shear discharges and wall stabilization on JT-60U

    International Nuclear Information System (INIS)

    Takeji, S.; Tokuda, S.; Fujita, T.; Suzuki, T.; Isayama, A.; Ide, S.; Ishii, Y.; Kamada, Y.; Koide, Y.; Matsumoto, T.; Oikawa, T.; Ozeki, T.; Sakamoto, Y.

    2001-01-01

    Resistive instabilities and wall stabilization of ideal low toroidal mode number, n, kink modes are investigated in JT-60U reversed shear discharges. Resistive interchange modes with n=1 are found to appear in reversed shear discharges with large pressure gradient at the normalized beta, β N , of about unity or even lower. The resistive interchange modes appear as intermittent burst-like magnetohydrodynamic (MHD) activities and higher n≤3 modes are observed occasionally in higher β N regime. No clear degradation of the plasma stored energy is observed by the resistive interchange modes themselves. It is also found that resistive interchange modes can lead to major collapse owing to a coupling with tearing modes at the outer mode rational surface over the minimum safety factor. Stability analysis revealed that stability parameter of tearing modes, Δ' , at the outer mode rational surface is affected by the free-boundary condition. The result is consistent with the experimental evidence that major collapse tends to occur when plasma edge safety factor, q*, is near integer values. Stabilization of ideal low n kink modes by the JT-60U wall is demonstrated. Magnetohydrodynamic perturbations that are attributed to resistive wall modes are observed followed by major collapse in wall-stabilized discharges. (author)

  20. Failure mechanism of shear-wall dominant multi-story buildings

    Science.gov (United States)

    Yuksel, S.B.; Kalkan, E.

    2008-01-01

    The recent trend in the building industry of Turkey as well as in many European countries is towards utilizing the tunnel form (shear-wall dominant) construction system for development of multi-story residential units. The tunnel form buildings diverge from other conventional reinforced concrete (RC) buildings due to the lack of beams and columns in their structural integrity. The vertical load-carrying members of these buildings are the structural-walls only, and the floor system is a flat plate. Besides the constructive advantages, tunnel form buildings provide superior seismic performance compared to conventional RC frame and dual systems as observed during the recent devastating earthquakes in Turkey (1999 Mw 7.4 Kocaeli, Mw 7.2 Duzce, and 2004 Mw 6.5 Bingol). With its proven earthquake performance, the tunnel form system is becoming the primary construction technique in many seismically active regions. In this study, a series of nonlinear analyses were conducted using finite element (FE) models to augment our understanding on their failure mechanism under lateral forces. In order to represent the nonlinear behavior adequately, The FE models were verified with the results of experimental studies performed on three dimensional (3D) scaled tunnel form building specimens. The results of this study indicate that the structural walls of tunnel form buildings may exhibit brittle flexural failure under lateral loading, if they are not properly reinforced. The global tension/compression couple triggers this failure mechanism by creating pure axial tension in the outermost shear-walls.

  1. Vessel wall MRI of the thoracic aorta: correlation to histology and transesophageal ultrasound. Preliminary results

    International Nuclear Information System (INIS)

    Abolmaali, N.; Schick, C.; Thalhammer, A.; Schmitt, J.; Vogl, T.J.; Langenfeld, M.; Schaechinger, V.; Krahforst, R.; Schulze, T.

    2002-01-01

    Purpose: To visualise the vessel wall of the descending thoracic aorta using magnetic resonance imaging. To evaluate the diagnostic potential of tailored T 1 -weighted sequences with contrast enhancement to assess systemic atherosclerotic disease. Methods: This study was performed on a clinical 1.5 Tesla scanner using a gradient strength of 30 mT/m and the phased array spine coil. A cadaver was examined to optimise a magnetic resonance imaging (MRI) protocol to evaluate atherosclerotic aortic wall disease. The acquired MR images were compared to gross specimens and histology. Subsequently seven patients who had undergone transesophageal ultrasound (TEU) with detailed assessment of the descending thoracic aorta were examined with MRI. The optimised protocol included untriggered and fat suppressed T 2 -weighted turbo spin echo sequences and ECG-triggered and fat suppressed T 1 -weighted spin echo sequences before and after iv administration of Gd-DTPA. Findings of the MR images were compared to the results of TEU. Contrast enhancement measurements were performed in normal and thickened vessel wall segments. Results: For the cadaver study a good correlation of the degree of vessel wall thickening and the extent of plaque imaged with the applied MR protocol was found. Tissue characterisation was limited due to post mortem changes. In vivo ECG-triggered T 1 -weighted images showed good correlation to TEU in terms of vessel wall thickness and plaque extension as verified by means of consensus reading. Differentiation of the plaque components fat, calcium and fibrous tissue was possible. In thickened aortic wall segments and fibrous caps a mean contrast enhancement of 50.4%±23.5% was measurable while normal wall segments showed an enhancement of 6.7%±3.1%. (orig.) [de

  2. SCF analysis of a pressurized vessel-nozzle intersection with wall thinning damage

    International Nuclear Information System (INIS)

    Qadir, M.; Redekop, D.

    2009-01-01

    A three-dimensional finite element analysis is carried out of a pressurized vessel-nozzle intersection (tee joint), with wall thinning damage. A convergence-validation study is first carried out for undamaged intersections, in which comparisons are made with previously published work for the stress concentration factor (SCF), and good agreement is observed. A study is then carried out for specific tee joints to examine the effect on the SCF of varying the extent of the wall thinning damage. Finally, a parametric study is conducted in which the SCF is computed for a wide range of tee joints, initially considered undamaged, and then with wall thinning damage.

  3. Development of automated welding process for field fabrication of thick walled pressure vessels

    International Nuclear Information System (INIS)

    Schneider, U.A.

    Research on automatic welding processes for the fabrication of thick-walled pressure vessels continued. A literature review on the subject was completed. A laboratory study of criteria for judging acceptable root parameters continued. Equipment for a demonstration facility to test the components and processes of the automated welding system has been specified and is being obtained

  4. Recovery process of wall condition in KSTAR vacuum vessel after temporal machine-vent for repair

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kwang Pyo, E-mail: kpkim@nfri.er.ke; Hong, Suk-Ho; Lee, Hyunmyung; Song, Jae-in; Jung, Nam-Yong; Lee, Kunsu; Chu, Yong; Kim, Hakkun; Park, Kaprai; Oh, Yeong-Kook

    2015-10-15

    Highlights: • Efforts have been made to obtain vacuum condition that is essential for the plasma experiments. • For example, the vacuum vessel should be vented to repair in-vessel components such as diagnostic shutter, and PFC damaged by high energy plasma. • Here, we present the recovery process of wall condition in KSTAR after temporal machine-vent for repair. • It is found that an acceptable vacuum condition has been achieved only by plasma based wall conditioning techniques such as baking, GDC, and boronization. • This study was that the proper recovering method of the vacuum condition should be developed according to the severity of the accident. - Abstract: Efforts have been made to obtain vacuum condition that is essential for the plasma experiments. Under certain situations, for example, the vacuum vessel should be vented to repair in-vessel components such as diagnostic shutter, exchange of window for diagnostic equipment, and PFC damaged by high energy plasma. For the quick restart of the campaign, a recovery process was established to make the vacuum condition acceptable for the plasma experiment. In this paper, we present the recovery process of wall condition in KSTAR after temporal machine-vent for repair. It is found that an acceptable vacuum condition has been achieved only by plasma based wall conditioning techniques such as baking, GDC, and boronization. This study was that the proper recovering method of the vacuum condition should be developed according to the severity of the accident.

  5. Development of automated welding process for field fabrication of thick walled pressure vessels

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, U A

    1981-01-01

    Research on automatic welding processes for the fabrication of thick-walled pressure vessels continued. A literature review on the subject was completed. A laboratory study of criteria for judging acceptable root parameters continued. Equipment for a demonstration facility to test the components and processes of the automated welding system has been specified and is being obtained. (LCL)

  6. Transient temperature and stress distributions in the pressure vessel's wall of a nuclear reactor

    International Nuclear Information System (INIS)

    Silva, G.A. da

    1979-01-01

    In order to calculate the temperature distribution in a reactor vessel wall which is under the effect of gamma radiation originated in the reactor core, a numerical solution is proposed. This problem may arise from a reactor cooling pump failure .The thermal stresses are also calculated. (Author) [pt

  7. Shear-stress and wall-stress regulation of vascular remodeling after balloon angioplasty: effect of matrix metalloproteinase inhibition

    NARCIS (Netherlands)

    C.J. Slager (Cornelis); J. Kloet (Jeroen); J.A.F. Oomen; J.C.H. Schuurbiers (Johan); B.J. de Smet; M.J. Post (Mark); D.P.V. de Kleijn (Dominique); G. Pasterkamp (Gerard); R. Krams (Rob); C. Borst (Cornelius); J.J. Wentzel (Jolanda); I. Andhyiswara (Ivan)

    2001-01-01

    textabstractBACKGROUND: Constrictive vascular remodeling (VR) is the most significant component of restenosis after balloon angioplasty (PTA). Whereas in physiological conditions VR is associated with normalization of shear stress (SS) and wall stress (WS), after PTA

  8. Effects of X-irradiation on artificial blood vessel wall degradation by invasive tumor cells

    International Nuclear Information System (INIS)

    Heisel, M.A.; Laug, W.E.; Stowe, S.M.; Jones, P.A.

    1984-01-01

    Artificial vessel wall cultures, constructed by growing arterial endothelial cells on preformed layers of rat smooth muscle cells, were used to evaluate the effects of X-irradiation on tumor cell-induced tissue degradation. Bovine endothelial cells had radiation sensitivities similar to those of rat smooth muscle cells. Preirradiation of smooth muscle cells, before the addition of human fibrosarcoma (HT 1080) cells, did not increase the rate of degradation and destruction by the invasive cells. However, the degradation rate was decreased if the cultures were irradiated after the addition of HT 1080 cells. The presence of bovine endothelial cells markedly inhibited the destructive abilities of fibrosarcoma cells, but preirradiation of artificial vessel walls substantially decreased their capabilities to resist HT 1080-induced lysis. These findings suggest that the abilities of blood vessels to limit extravasation may be compromised by ionizing radiation

  9. Evaluation of Nonlinear Behavior of Dual Steel Frame-Shear Wall System by a Group of Real Earthquakes

    OpenAIRE

    Reza Bemanian; Hamzeh Shakib

    2016-01-01

    Dual system of steel moment frame and steel plate shear wall has many advantages in comparison to the other systems. Since the last four decades the dual system has been used more frequently in new and existing structures. the steel shear wall has many advantages such as high ductility, strength, stiffness and it has light weight, it consequent reduce lateral forces and time efficiency in contracture procedure. The aim of this study is to evaluate the seismic performance of the dual steel fra...

  10. Reactor pressure vessel failure probability following through-wall cracks due to pressurized thermal shock events

    International Nuclear Information System (INIS)

    Simonen, F.A.; Garnich, M.R.; Simonen, E.P.; Bian, S.H.; Nomura, K.K.; Anderson, W.E.; Pedersen, L.T.

    1986-04-01

    A fracture mechanics model was developed at the Pacific Northwest Laboratory (PNL) to predict the behavior of a reactor pressure vessel following a through-wall crack that occurs during a pressurized thermal shock (PTS) event. This study, which contributed to a US Nuclear Regulatory Commission (NRC) program to study PTS risk, was coordinated with the Integrated Pressurized Thermal Shock (IPTS) Program at Oak Ridge National Laboratory (ORNL). The PNL fracture mechanics model uses the critical transients and probabilities of through-wall cracks from the IPTS Program. The PNL model predicts the arrest, reinitiation, and direction of crack growth for a postulated through-wall crack and thereby predicts the mode of vessel failure. A Monte-Carlo type of computer code was written to predict the probabilities of the alternative failure modes. This code treats the fracture mechanics properties of the various welds and plates of a vessel as random variables. Plant-specific calculations were performed for the Oconee-1, Calvert Cliffs-1, and H.B. Robinson-2 reactor pressure vessels for the conditions of postulated transients. The model predicted that 50% or more of the through-wall axial cracks will turn to follow a circumferential weld. The predicted failure mode is a complete circumferential fracture of the vessel, which results in a potential vertically directed missile consisting of the upper head assembly. Missile arrest calculations for the three nuclear plants predict that such vertical missiles, as well as all potential horizontally directed fragmentation type missiles, will be confined to the vessel enclosre cavity. The PNL failure mode model is recommended for use in future evaluations of other plants, to determine the failure modes that are most probable for postulated PTS events

  11. Role of Outgassing of ITER Vacuum Vessel In-Wall Shielding Materials in Leak Detection of ITER Vacuum Vessel

    Science.gov (United States)

    Maheshwari, A.; Pathak, H. A.; Mehta, B. K.; Phull, G. S.; Laad, R.; Shaikh, M. S.; George, S.; Joshi, K.; Khan, Z.

    2017-04-01

    ITER Vacuum Vessel is a torus-shaped, double wall structure. The space between the double walls of the VV is filled with In-Wall Shielding Blocks (IWS) and Water. The main purpose of IWS is to provide neutron shielding during ITER plasma operation and to reduce ripple of Toroidal Magnetic Field (TF). Although In-Wall Shield Blocks (IWS) will be submerged in water in between the walls of the ITER Vacuum Vessel (VV), Outgassing Rate (OGR) of IWS materials plays a significant role in leak detection of Vacuum Vessel of ITER. Thermal Outgassing Rate of a material critically depends on the Surface Roughness of material. During leak detection process using RGA equipped Leak detector and tracer gas Helium, there will be a spill over of mass 3 and mass 2 to mass 4 which creates a background reading. Helium background will have contribution of Hydrogen too. So it is necessary to ensure the low OGR of Hydrogen. To achieve an effective leak test it is required to obtain a background below 1 × 10-8 mbar 1 s-1 and hence the maximum Outgassing rate of IWS Materials should comply with the maximum Outgassing rate required for hydrogen i.e. 1 x 10-10 mbar 1 s-1 cm-2 at room temperature. As IWS Materials are special materials developed for ITER project, it is necessary to ensure the compliance of Outgassing rate with the requirement. There is a possibility of diffusing the gasses in material at the time of production. So, to validate the production process of materials as well as manufacturing of final product from this material, three coupons of each IWS material have been manufactured with the same technique which is being used in manufacturing of IWS blocks. Manufacturing records of these coupons have been approved by ITER-IO (International Organization). Outgassing rates of these coupons have been measured at room temperature and found in acceptable limit to obtain the required Helium Background. On the basis of these measurements, test reports have been generated and got

  12. Protective interior wall and attaching means for a fusion reactor vacuum vessel

    International Nuclear Information System (INIS)

    Phelps, R.D.; Upham, G.A.; Anderson, P.M.

    1988-01-01

    A protective wall for the interior surface of a fusion reactor vessel wall is described comprising: an array of plates, each plate of the array including a main body section, a pair of edge sections bent at an angle with respect to the main body section, and a pair of flange-like end sections each having protruding sections with cut-aways therein, the protruding sections of the flange-like end sections extending in a direction substantially parallel to the main body section; and means operatively associated with the protruding sections of the flange-like end sections of the plates for mounting the array of plates to an associated vessel wall to be protected

  13. Velocity profile and wall shear stress of saccular aneurysms at the anterior communicating artery.

    Science.gov (United States)

    Yamaguchi, Ryuhei; Ujiie, Hiroshi; Haida, Sayaka; Nakazawa, Nobuhiko; Hori, Tomokatsu

    2008-01-01

    It has recently been shown that the aspect ratio (dome/neck) of an aneurysm correlates well with intraaneurysmal blood flow. Aneurysms with an aspect ratio larger than 1.6 carry a higher risk of rupture. We examined the effect of aspect ratio (AR) on intra-aneurysmal flow using experimental models. Flow visualization with particle imaging velocimetry and measurement of wall shear stress using laser Doppler anemometry were performed on three different aneurysm models: AR 0.5, 1.0, and 2.0. Intraaneurysmal flow consists of inflow, circulation, and outflow. Rapid inflow impinged on the distal neck creating a stagnant point. Rapid flow and maximum wall shear stress were observed in the vicinity of the stagnant point. By changing the Reynold's number, the stagnant point moved. By increasing the AR of the aneurysm, vortices inside the aneurysm sac closed and very slow flow was observed, resulting in very low shear stress markedly at a Reynold's number of 250, compatible with the diastolic phase. In the aneurysm model AR 2.0, both rapid flow at the neck and vortices inside the aneurysm are sufficient to activate platelets, making a thrombus that may anchor on the dome where very slow flow takes place. Hemodynamics in aneurysms larger than AR 2.0 definitely contribute to thrombus formation.

  14. Innovative Seismic Response-Controlled System with Shear Wall and Concentrated Dampers in Lower Stories

    Directory of Open Access Journals (Sweden)

    Tsubasa Tani

    2017-10-01

    Full Text Available A new structural control system using damper-installed shear walls in lower stories with reduced stiffness is proposed for vibration control of high-rise RC buildings. That system has some design variables, i.e., height of shear wall, degree of stiffness reduction at lower stories, and quantity of dampers. In this paper, some parametric studies on the shear-beam model with a stiff beam against two kinds of ground motion, a pulse-type sinusoidal wave and a resonant sinusoidal wave, are conducted to clarify the vibration characteristics of the proposed structural control system. It is shown that the optimal combination of design parameters depends on the input ground motion. It is also shown that it is possible to prevent from increasing the response under the one-cycle sinusoidal input resonant to the lowest mode and reduce the steady-state response under the harmonic input with the resonant fundamental period by reducing the stiffness in the lower structure and increasing the damper deformation.

  15. Design, fabrication and test of double-wall vacuum vessel for JT-60U

    International Nuclear Information System (INIS)

    Uchikawa, Takashi; Ioki, Kimihiro; Ninomiya, Hiromasa.

    1994-01-01

    A double-wall vacuum vessel was designed and fabricated for JT-60U (an upgraded machine of JT-60), which has a plasma current up to 6 MA and a large plasma volume (100 m 3 ). A new concept of Inconel 625 all-welded structure was adopted to the vessel, that comprises an inner plate, square tubes and an outer plate. The vacuum vessel with a multi-arc D-shaped cross section was fabricated by using hot-sizing press. The electromagnetic and structural analysis has been performed for plasma disruption loads. Dynamic responses of the vessel were measured during plasma disruptions, and the observed displacement had a good agreement with the result of FEM analysis. (author)

  16. The design of lifting attachments for the erection of large diameter and heavy wall pressure vessels

    International Nuclear Information System (INIS)

    Antalffy, Leslie P.; Miller, George A.; Kirkpatrick, Kenneth D.; Rajguru, Anil; Zhu, Yong

    2016-01-01

    Lifting attachments for the erection of large diameter and heavy wall pressure vessels require special consideration to ensure that their attachment to their vessel shells or heads do not overstress the vessel during the erection process when lifting these from grade onto their respective foundations. Today, in refinery and petrochemical services, large diameter vessels with diameters ranging up to 15 m and reactors with lifting weights in the range of 700–1400 tons are not uncommon. In today's fabrication market, these vessels may be purchased and fabricated in shops dispersed globally and will require unique equipment for their safe handling, transportation and subsequent erection. The challenge is to design the lifting attachments in such a manner that the attachments provide a safe, cost effective and effective solution based upon the limitations of the job site lift equipment available for erection. Such equipment for the transportation and subsequent lifting of large diameter and heavy wall pressure equipment is usually scarce and quite expensive. Planning ahead, well in advance of the lift date is almost a mandatory requirement. Usually, the specific parameters of the vessel to be lifted and the lifting equipment available at the site will dictate the type of lifting attachments to be designed for the vessel. Once the type of vessel attachment has been chosen, careful consideration must be given to the design of attachments to the pressure vessel in consideration to ensure that the vessel and lifting components are not overstressed during the lifting process. The paper also discusses different types of lifting attachments that may be attached to each end of the vessel either by bolting or welding and discusses the pros and cons of each. The paper also provides an example of a finite element analysis (FEA) of a top nozzle, a FEA of a pair of lifting trunnions and a FEA of welded on lifting lugs for buried pipe. The purpose of the paper is to outline the

  17. Localized modelling and feedback control of linear instabilities in 2-D wall bounded shear flows

    Science.gov (United States)

    Tol, Henry; Kotsonis, Marios; de Visser, Coen

    2016-11-01

    A new approach is presented for control of instabilities in 2-D wall bounded shear flows described by the linearized Navier-Stokes equations (LNSE). The control design accounts both for spatially localized actuators/sensors and the dominant perturbation dynamics in an optimal control framework. An inflow disturbance model is proposed for streamwise instabilities that drive laminar-turbulent transition. The perturbation modes that contribute to the transition process can be selected and are included in the control design. A reduced order model is derived from the LNSE that captures the input-output behavior and the dominant perturbation dynamics. This model is used to design an optimal controller for suppressing the instability growth. A 2-D channel flow and a 2-D boundary layer flow over a flat plate are considered as application cases. Disturbances are generated upstream of the control domain and the resulting flow perturbations are estimated/controlled using wall shear measurements and localized unsteady blowing and suction at the wall. It will be shown that the controller is able to cancel the perturbations and is robust to unmodelled disturbances.

  18. Wall shear stress characterization of a 3D bluff-body separated flow

    Science.gov (United States)

    Fourrié, Grégoire; Keirsbulck, Laurent; Labraga, Larbi

    2013-10-01

    Efficient flow control strategies aimed at reducing the aerodynamic drag of road vehicles require a detailed knowledge of the reference flow. In this work, the flow around the rear slanted window of a generic car model was experimentally studied through wall shear stress measurements using an electrochemical method. The mean and fluctuating wall shear stress within the wall impact regions of the recirculation bubble and the main longitudinal vortex structures which develop above the rear window are presented. Correlations allow a more detailed characterization of the recirculation phenomenon within the separation bubble. In the model symmetry plane the recirculation structure compares well with simpler 2D configurations; specific lengths, flapping motion and shedding of large-scale vortices are observed, these similarities diminish when leaving the middle plane due to the strong three-dimensionality of the flow. A specific attention is paid to the convection processes occurring within the recirculation: a downstream convection velocity is observed, in accordance with 2D recirculations from the literature, and an upstream convection is highlighted along the entire bubble length which has not been underlined in some previous canonical configurations.

  19. The Effect of Shear Wall Distribution on the Dynamics of Reinforced Concrete Structures

    Science.gov (United States)

    Helou, S. H.; Touqan, A. R.

    2008-07-01

    The inclusion of a soft storey in multistory concrete buildings is a feature gaining popularity in urban areas where land is of exorbitant cost. In earthquake prone zones, this feature has been observed in post earthquake investigations. Although engineers are prepared to accept the notion that a soft storey poses a weak link in Seismic Design, yet the idea demands better understanding. The following study illustrates the importance of the judicious distribution of shear walls. The selected building is analyzed through nine numerical models which address the behavior of framed structures. The parameters discussed include, inter alias, the fundamental period of vibration, lateral displacements, axial and shear forces. It is noticed that an abrupt change in stiffness between the soft storey and the level above is responsible for increasing the strength demand on first storey columns. Extending the elevator shafts throughout the soft storey is strongly recommended.

  20. The Effect of Shear Wall Distribution on the Dynamics of Reinforced Concrete Structures

    International Nuclear Information System (INIS)

    Helou, S. H.; Touqan, A. R.

    2008-01-01

    The inclusion of a soft storey in multistory concrete buildings is a feature gaining popularity in urban areas where land is of exorbitant cost. In earthquake prone zones, this feature has been observed in post earthquake investigations. Although engineers are prepared to accept the notion that a soft storey poses a weak link in Seismic Design, yet the idea demands better understanding. The following study illustrates the importance of the judicious distribution of shear walls. The selected building is analyzed through nine numerical models which address the behavior of framed structures. The parameters discussed include, inter alias, the fundamental period of vibration, lateral displacements, axial and shear forces. It is noticed that an abrupt change in stiffness between the soft storey and the level above is responsible for increasing the strength demand on first storey columns. Extending the elevator shafts throughout the soft storey is strongly recommended

  1. Structural performance of new thin-walled concrete sandwich panel system reinforced with bfrp shear connectors

    DEFF Research Database (Denmark)

    Hodicky, Kamil; Hulin, Thomas; Schmidt, Jacob Wittrup

    2013-01-01

    This paper presents a new thin-walled concrete sandwich panel system reinforced with basalt fiber-reinforced plastic (BFRP) with optimum structural performances and a high thermal resistance developed by Connovate and Technical University of Denmark. The shear connecting system made of a BFRP grid...... is described and provides information on the structural design with its advantages. Experimental and numerical investigations of the BFRP connecting systems were performed. The experimental program included testing of small scale specimens by applying shear (push-off) loading and semi-full scale specimens...... on finite element modelling showed that the developed panel system meets the objectives of the research and is expected to have promising future....

  2. Hysteretic evaluation of seismic performance of normal and fiber reinforced concrete shear walls

    International Nuclear Information System (INIS)

    Choun, Young Sun; Hahm, Dae Gi

    2012-01-01

    The use of fibers in concrete or cement composites can enhance the performance of structural elements. Fibers have been used for a cement mixture to increase the toughness and tensile strength, and to improve the cracking and deformation characteristics. The addition of fibers into concrete can improve the ductility and increase the seismic resistance of concrete structures. The application of fibers to earthquake-resistant concrete structures has a major research topic. A recent study shows that an excellent seismic performance can be obtained in shear critical members constructed with high performance fiber reinforced cement composites. To increase the seismic performance of safety related concrete structures in nuclear power plants, fibers can be used. This study investigated the effect of fibers on the hysteretic behavior of a reinforced concrete (RC) shear wall by cyclic tests

  3. Hysteretic evaluation of seismic performance of normal and fiber reinforced concrete shear walls

    Energy Technology Data Exchange (ETDEWEB)

    Choun, Young Sun; Hahm, Dae Gi [KAERI, Daejeon (Korea, Republic of)

    2012-10-15

    The use of fibers in concrete or cement composites can enhance the performance of structural elements. Fibers have been used for a cement mixture to increase the toughness and tensile strength, and to improve the cracking and deformation characteristics. The addition of fibers into concrete can improve the ductility and increase the seismic resistance of concrete structures. The application of fibers to earthquake-resistant concrete structures has a major research topic. A recent study shows that an excellent seismic performance can be obtained in shear critical members constructed with high performance fiber reinforced cement composites. To increase the seismic performance of safety related concrete structures in nuclear power plants, fibers can be used. This study investigated the effect of fibers on the hysteretic behavior of a reinforced concrete (RC) shear wall by cyclic tests.

  4. Development of a rocking R/C shear wall system implementing repairable structural fuses

    Science.gov (United States)

    Parsafar, Saeed; Moghadam, Abdolreza S.

    2017-09-01

    In the last decades, the concept of earthquake resilient structural systems is becoming popular in which the rocking structure is considered as a viable option for buildings in regions of high seismicity. To this end, a novel wall-base connection based on the " repairable structure" approach is proposed and evaluated. The proposed system is made of several steel plates and high strength bolts act as a friction connection. To achieve the desired rocking motion in the proposed system, short-slotted holes are used in vertical directions for connecting the steel plates to the shear wall (SW). The experimental and numerical studies were performed using a series of displacement control quasi-static cyclic tests on a reference model and four different configurations of the proposed connection installed at the wall corners. The seismic response of the proposed system is compared to the conventional SW in terms of energy dissipation and damage accumulation. In terms of energy dissipation, the proposed system depicted better performance with 95% more energy dissipation capability compared to conventional SW. In terms of damage accumulation, the proposed SW system is nearly undamaged compared to the conventional wall system, which was severely damaged at the wall-base region. Overall, the introduced concept presents a feasible solution for R/C structures when a low-damage design is targeted, which can improve the seismic performance of the structural system significantly.

  5. Contribution of the different erosion processes to material release from the vessel walls of fusion devices during plasma operation

    International Nuclear Information System (INIS)

    Behrisch, R.

    2002-01-01

    In high temperature plasma experiments several processes contribute to erosion and loss of material from the vessel walls. This material may enter the plasma edge and the central plasma where it acts as impurities. It will finally be re-deposited at other wall areas. These erosion processes are: evaporation due to heating of wall areas. At very high power deposition evaporation may become very large, which has been named ''blooming''. Large evaporation and melting at some areas of the vessel wall surface may occur during heat pulses, as observed in plasma devices during plasma disruptions. At tips on the vessel walls and/or hot spots on the plasma exposed solid surfaces electrical arcs between the plasma and the vessel wall may ignite. They cause the release of ions, atoms and small metal droplets, or of carbon dust particles. Finally, atoms from the vessel walls are removed by physical and chemical sputtering caused by the bombardment of the vessel walls with ions as well as energetic neutral hydrogen atoms from the boundary plasma. All these processes have been, and are, observed in today's plasma experiments. Evaporation can in principle be controlled by very effective cooling of the wall tiles, arcing is reduced by very stable plasma operation, and sputtering by ions can be reduced by operating with a cold plasma in front of the vessel walls. However, sputtering by energetic neutrals, which impinge on all areas of the vessel walls, is likely to be the most critical process because ions lost from the plasma recycle as neutrals or have to be refuelled by neutrals leading to the charge exchange processes in the plasma. In order to quantify the wall erosion, ''materials factors'' (MF) have been introduced in the following for the different erosion processes. (orig.)

  6. An overview of an experimental program for testing large reinforced concrete shear walls

    International Nuclear Information System (INIS)

    Farrar, C.R.; Bennett, J.G.

    1989-01-01

    The Seismic Category I Structures Program is being carried out at the Los Alamos National Laboratory under sponsorship of the US Nuclear Regulatory Commission (NRC), Office of Nuclear Regulatory Research. In the class of structure being investigated, the primary lateral load-resisting structural element is the reinforced concrete shear wall. Previous results from microconcrete models indicated that these structures responded to seismic excitations with initial frequencies that were reduced by factors of 2 or more over those calculated based on an uncracked cross-section strength-of-materials approach. Furthermore, though the structures themselves were shown to have sufficient reserve margins, the equipment and piping are designed to response spectra that are based on uncracked cross-sectional member properties, and these spectra may not be inappropriate for actual building responses. The current phase of the program is aimed at verification of these conclusions using conventional concrete structures to demonstrate that previous microconcrete results can be scaled to prototype structures. A new configuration of a shear wall structure was designed and tested to investigate the analytical-experimental differences observed during the previous model testing. Shear wall height-to-length aspect ratios were to vary from 1 to 0.25. Percentage steel ratios were to vary from 0.25% to 0.6% by area, in both horizontal and vertical directions. The test structures are shown in Fig. 1. TRG-1 and -2 were constructed with microconcrete. TRG-3, -4, -5, and -6 were constructed with conventional (19-mm aggregate) concrete. 11 refs., 4 figs

  7. Variable impact of CSF flow suppression on quantitative 3.0T intracranial vessel wall measurements.

    Science.gov (United States)

    Cogswell, Petrice M; Siero, Jeroen C W; Lants, Sarah K; Waddle, Spencer; Davis, L Taylor; Gilbert, Guillaume; Hendrikse, Jeroen; Donahue, Manus J

    2018-03-31

    Flow suppression techniques have been developed for intracranial (IC) vessel wall imaging (VWI) and optimized using simulations; however, simulation results may not translate in vivo. To evaluate experimentally how IC vessel wall and lumen measurements change in identical subjects when evaluated using the most commonly available blood and cerebrospinal fluid (CSF) flow suppression modules and VWI sequences. Prospective. Healthy adults (n = 13; age = 37 ± 15 years) were enrolled. A 3.0T 3D T 1 /proton density (PD)-weighted turbo-spin-echo (TSE) acquisition with post-readout anti-driven equilibrium module, with and without Delay-Alternating-with-Nutation-for-Tailored-Excitation (DANTE) was applied. DANTE flip angle (8-12°) and TSE refocusing angle (sweep = 40-120° or 50-120°) were varied. Basilar artery and internal carotid artery (ICA) wall thicknesses, CSF signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and signal ratio (SR) were assessed. Measurements were made by two readers (radiology resident and board-certified neuroradiologist). A Wilcoxon signed-rank test was applied with corrected two-sided P CSF suppression. Addition of the DANTE preparation reduced CSF SNR from 17.4 to 6.7, thereby providing significant (P CSF suppression. The DANTE preparation also resulted in a significant (P CSF CNR improvement (P = 0.87). There was a trend for a difference in blood SNR with vs. without DANTE (P = 0.05). The outer vessel wall diameter and wall thickness values were lower (P CSF suppression and CNR of the approaches evaluated. However, improvements are heterogeneous, likely owing to intersubject vessel pulsatility and CSF flow variations, which can lead to variable flow suppression efficacy in these velocity-dependent modules. 2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018. © 2018 International Society for Magnetic Resonance in Medicine.

  8. Spatio-temporal characteristics of large scale motions in a turbulent boundary layer from direct wall shear stress measurement

    Science.gov (United States)

    Pabon, Rommel; Barnard, Casey; Ukeiley, Lawrence; Sheplak, Mark

    2016-11-01

    Particle image velocimetry (PIV) and fluctuating wall shear stress experiments were performed on a flat plate turbulent boundary layer (TBL) under zero pressure gradient conditions. The fluctuating wall shear stress was measured using a microelectromechanical 1mm × 1mm floating element capacitive shear stress sensor (CSSS) developed at the University of Florida. The experiments elucidated the imprint of the organized motions in a TBL on the wall shear stress through its direct measurement. Spatial autocorrelation of the streamwise velocity from the PIV snapshots revealed large scale motions that scale on the order of boundary layer thickness. However, the captured inclination angle was lower than that determined using the classic method by means of wall shear stress and hot-wire anemometry (HWA) temporal cross-correlations and a frozen field hypothesis using a convection velocity. The current study suggests the large size of these motions begins to degrade the applicability of the frozen field hypothesis for the time resolved HWA experiments. The simultaneous PIV and CSSS measurements are also used for spatial reconstruction of the velocity field during conditionally sampled intense wall shear stress events. This material is based upon work supported by the National Science Foundation Graduate Research Fellowship under Grant No. DGE-1315138.

  9. Interaction between a normal shock wave and a turbulent boundary layer at high transonic speeds. Part 2: Wall shear stress

    Science.gov (United States)

    Liou, M. S.; Adamson, T. C., Jr.

    1979-01-01

    An analysis is presented of the flow in the two inner layers, the Reynolds stress sublayer and the wall layer. Included is the calculation of the shear stress at the wall in the interaction region. The limit processes considered are those used for an inviscid flow.

  10. JSC technician checks STS-44 DSO 316 bioreactor and rotating wall vessel hdwr

    Science.gov (United States)

    1991-01-01

    JSC technician Tacey Prewitt checks the progress on a bioreactor experiment in JSC's Life Sciences Laboratory Bldg 37 biotechnology laboratory. Similar hardware is scheduled for testing aboard Atlantis, Orbiter Vehicle (OV) 104, during STS-44. Detailed Supplementary Objective (DSO) 316 Bioreactor/Flow and Particle Trajectory in Microgravity will checkout the rotating wall vessel hardware and hopefully will confirm researchers' theories and calculations about how flow fields work in space. Plastic beads of various sizes rather than cell cultures are being flown in the vessel for the STS-44 test.

  11. Using digital holographic microscopy for simultaneous measurements of 3D near wall velocity and wall shear stress in a turbulent boundary layer

    Science.gov (United States)

    Sheng, J.; Malkiel, E.; Katz, J.

    2008-12-01

    A digital holographic microscope is used to simultaneously measure the instantaneous 3D flow structure in the inner part of a turbulent boundary layer over a smooth wall, and the spatial distribution of wall shear stresses. The measurements are performed in a fully developed turbulent channel flow within square duct, at a moderately high Reynolds number. The sample volume size is 90 × 145 × 90 wall units, and the spatial resolution of the measurements is 3 8 wall units in streamwise and spanwise directions and one wall unit in the wall-normal direction. The paper describes the data acquisition and analysis procedures, including the particle tracking method and associated method for matching of particle pairs. The uncertainty in velocity is estimated to be better than 1 mm/s, less than 0.05% of the free stream velocity, by comparing the statistics of the normalized velocity divergence to divergence obtained by randomly adding an error of 1 mm/s to the data. Spatial distributions of wall shear stresses are approximated with the least square fit of velocity measurements in the viscous sublayer. Mean flow profiles and statistics of velocity fluctuations agree very well with expectations. Joint probability density distributions of instantaneous spanwise and streamwise wall shear stresses demonstrate the significance of near-wall coherent structures. The near wall 3D flow structures are classified into three groups, the first containing a pair of counter-rotating, quasi streamwise vortices and high streak-like shear stresses; the second group is characterized by multiple streamwise vortices and little variations in wall stress; and the third group has no buffer layer structures.

  12. Seismic shear wall ISP NUPEC's seismic ultimate dynamic response test. Comparison report

    International Nuclear Information System (INIS)

    1996-01-01

    In the seismic design of a nuclear power plant, evaluation of the ultimate strength of the nuclear reactor building is an important subject for assessment of seismic reliability of the plant. In order to carry out the evaluation, the response characteristics of reinforced concrete seismic shear walls up to their ultimate state have to be understood. For this purpose, there is a need to develop reliable non-linear response analysis methods which enables the reliable ultimate strength evaluation of nuclear reactor buildings. Along with this need, many computer codes have been developed. These computer codes are compared. (K.A.)

  13. Axisymmetric wave propagation in gas shear flow confined by a rigid-walled pipeline

    International Nuclear Information System (INIS)

    Chen Yong; Huang Yi-Yong; Chen Xiao-Qian; Bai Yu-Zhu; Tan Xiao-Dong

    2015-01-01

    The axisymmetric acoustic wave propagating in a perfect gas with a shear pipeline flow confined by a circular rigid wall is investigated. The governing equations of non-isentropic and isentropic acoustic assumptions are mathematically deduced while the constraint of Zwikker and Kosten is relaxed. An iterative method based on the Fourier–Bessel theory is proposed to semi-analytically solve the proposed models. A comparison of numerical results with literature contributions validates the present contribution. Meanwhile, the features of some high-order transverse modes, which cannot be analyzed based on the Zwikker and Kosten theory, are analyzed (paper)

  14. Seismic Performance and Design of Steel Plate Shear Walls with Low Yield Point Steel Infill Plates

    OpenAIRE

    Zirakian, Tadeh

    2013-01-01

    Steel plate shear walls (SPSWs) have been frequently used as the primary or part of the primary lateral force-resisting system in design of low-, medium-, and high-rise buildings. Their application has been based on two different design philosophies as well as detailing strategies. Stiffened and/or stocky-web SPSWs with improved buckling stability and high seismic performance have been mostly used in Japan, which is one of the pioneering countries in design and application of these systems. U...

  15. Analytical and experimental evaluation of the capacity of the bottom rail in partially anchored timber shear walls

    OpenAIRE

    Caprolu, Giuseppe; Källsner, Bo; Girhammar, Ulf Arne; Vessby, Johan

    2012-01-01

    Källsner and Girhammar have developed plastic design methods for light-frame timber shear walls that can be used for determining the load-carrying capacity when the shear walls are partially anchored. For such walls, the leading stud is not fully anchored against uplift and tying down forces are developed in the sheathing-to-framing joints. Since the forces in the anchor bolts and the sheathing-to-framing joints do not act in the same vertical plane, the bottom rail will be subjected to cross...

  16. Experimental, numerical, and analytical studies on the seismic response of steel-plate concrete (SC) composite shear walls

    Science.gov (United States)

    Epackachi, Siamak

    The seismic performance of rectangular steel-plate concrete (SC) composite shear walls is assessed for application to buildings and mission-critical infrastructure. The SC walls considered in this study were composed of two steel faceplates and infill concrete. The steel faceplates were connected together and to the infill concrete using tie rods and headed studs, respectively. The research focused on the in-plane behavior of flexure- and flexure-shear-critical SC walls. An experimental program was executed in the NEES laboratory at the University at Buffalo and was followed by numerical and analytical studies. In the experimental program, four large-size specimens were tested under displacement-controlled cyclic loading. The design variables considered in the testing program included wall thickness, reinforcement ratio, and slenderness ratio. The aspect ratio (height-to-length) of the four walls was 1.0. Each SC wall was installed on top of a re-usable foundation block. A bolted baseplate to RC foundation connection was used for all four walls. The walls were identified to be flexure- and flexure-shear critical. The progression of damage in the four walls was identical, namely, cracking and crushing of the infill concrete at the toes of the walls, outward buckling and yielding of the steel faceplates near the base of the wall, and tearing of the faceplates at their junctions with the baseplate. A robust finite element model was developed in LS-DYNA for nonlinear cyclic analysis of the flexure- and flexure-shear-critical SC walls. The DYNA model was validated using the results of the cyclic tests of the four SC walls. The validated and benchmarked models were then used to conduct a parametric study, which investigated the effects of wall aspect ratio, reinforcement ratio, wall thickness, and uniaxial concrete compressive strength on the in-plane response of SC walls. Simplified analytical models, suitable for preliminary analysis and design of SC walls, were

  17. Influence of acquired obesity on coronary vessel wall late gadolinium enhancement in discordant monozygote twins

    Energy Technology Data Exchange (ETDEWEB)

    Makowski, Marcus R. [King' s College London, Division of Imaging Sciences and Biomedical Engineering, London (United Kingdom); Wellcome Trust and EPSRC Medical Engineering Centre, London (United Kingdom); King' s College London, BHF Centre of Excellence, London (United Kingdom); King' s College London, NIHR Biomedical Research Centre, London (United Kingdom); Charite-Universitaetsmedizin, Department of Radiology, Berlin (Germany); Jansen, Christian H.P. [King' s College London, Division of Imaging Sciences and Biomedical Engineering, London (United Kingdom); Ebersberger, Ullrich; Spector, Tim D. [Heart Center Munich-Bogenhausen, Department of Cardiology and Intensive Care Medicine, Munich (Germany); Schaeffter, Tobias; Razavi, Reza [King' s College London, Division of Imaging Sciences and Biomedical Engineering, London (United Kingdom); Wellcome Trust and EPSRC Medical Engineering Centre, London (United Kingdom); King' s College London, BHF Centre of Excellence, London (United Kingdom); King' s College London, NIHR Biomedical Research Centre, London (United Kingdom); Mangino, Massimo [King' s College London, Department of Twin Research and Genetic Epidemiology, London (United Kingdom); National Institute for Health Research (NIHR) Biomedical Research Centre at Guy' s and St. Thomas' Foundation Trust, London (United Kingdom); Botnar, Rene M. [King' s College London, Division of Imaging Sciences and Biomedical Engineering, London (United Kingdom); Wellcome Trust and EPSRC Medical Engineering Centre, London (United Kingdom); King' s College London, BHF Centre of Excellence, London (United Kingdom); King' s College London, NIHR Biomedical Research Centre, London (United Kingdom); Greil, Gerald F. [King' s College London, Division of Imaging Sciences and Biomedical Engineering, London (United Kingdom); Wellcome Trust and EPSRC Medical Engineering Centre, London (United Kingdom); King' s College London, BHF Centre of Excellence, London (United Kingdom); King' s College London, NIHR Biomedical Research Centre, London (United Kingdom)

    2017-11-15

    The aim of this study was to investigate the impact of BMI on late gadolinium enhancement (LGE) of the coronary artery wall in identical monozygous twins discordant for BMI. Coronary LGE represents a useful parameter for the detection and quantification of atherosclerotic coronary vessel wall disease. Thirteen monozygote female twin pairs (n = 26) with significantly different BMIs (>1.6 kg/m2) were recruited out of >10,000 twin pairs (TwinsUK Registry). A coronary 3D-T2prep-TFE MR angiogram and 3D-IR-TFE vessel wall scan were performed prior to and following the administration of 0.2 mmol/kg of Gd-DTPA on a 1.5 T MR scanner. The number of enhancing coronary segments and contrast to noise ratios (CNRs) of the coronary wall were quantified. An increase in BMI was associated with an increased number of enhancing coronary segments (5.3 ± 1.5 vs. 3.5 ± 1.6, p < 0.0001) and increased coronary wall enhancement (6.1 ± 1.1 vs. 4.8 ± 0.9, p = 0.0027) compared to matched twins with lower BMI. This study in monozygous twins indicates that acquired factors predisposing to obesity, including lifestyle and environmental factors, result in increased LGE of the coronary arteries, potentially reflecting an increase in coronary atherosclerosis in this female study population. (orig.)

  18. Influence of acquired obesity on coronary vessel wall late gadolinium enhancement in discordant monozygote twins

    International Nuclear Information System (INIS)

    Makowski, Marcus R.; Jansen, Christian H.P.; Ebersberger, Ullrich; Spector, Tim D.; Schaeffter, Tobias; Razavi, Reza; Mangino, Massimo; Botnar, Rene M.; Greil, Gerald F.

    2017-01-01

    The aim of this study was to investigate the impact of BMI on late gadolinium enhancement (LGE) of the coronary artery wall in identical monozygous twins discordant for BMI. Coronary LGE represents a useful parameter for the detection and quantification of atherosclerotic coronary vessel wall disease. Thirteen monozygote female twin pairs (n = 26) with significantly different BMIs (>1.6 kg/m2) were recruited out of >10,000 twin pairs (TwinsUK Registry). A coronary 3D-T2prep-TFE MR angiogram and 3D-IR-TFE vessel wall scan were performed prior to and following the administration of 0.2 mmol/kg of Gd-DTPA on a 1.5 T MR scanner. The number of enhancing coronary segments and contrast to noise ratios (CNRs) of the coronary wall were quantified. An increase in BMI was associated with an increased number of enhancing coronary segments (5.3 ± 1.5 vs. 3.5 ± 1.6, p < 0.0001) and increased coronary wall enhancement (6.1 ± 1.1 vs. 4.8 ± 0.9, p = 0.0027) compared to matched twins with lower BMI. This study in monozygous twins indicates that acquired factors predisposing to obesity, including lifestyle and environmental factors, result in increased LGE of the coronary arteries, potentially reflecting an increase in coronary atherosclerosis in this female study population. (orig.)

  19. Vessel wall and indium-111-labelled platelet response to carotid endarterectomy

    International Nuclear Information System (INIS)

    Lusby, R.J.; Ferrell, L.D.; Englestad, B.L.; Price, D.C.; Lipton, M.J.; Stoney, R.J.

    1983-01-01

    Postendarterectomy platelet deposition and thrombus formation may play an important role not only in vessel wall healing but also in the small incidence of postoperative cerebral ischemia and postoperative stenosis. A study has been performed using a canine model to investigate the healing response to carotid endarterectomy and the validity of an in vivo indium-111 (In-111) radiotracer technique in the assessment of postendarterectomy deposition of autologous labelled platelets. Sixteen endarterectomized carotid arteries showed uptake of autologous In-111 platelets immediately after infusion, reaching a maximum by 1 hour with little increase at 24 or 48 hours. No uptake was seen in ten control vessels following platelet infusion (P less than 0.05). At autopsy, seven vessels were demonstrated to have In-111 platelet deposition immediately prior to sacrifice of the animals. Postmortem scanning confirmed the localization to the vessel lumens, and microscopy revealed thrombus formation with or without partial endothelialization. Complete reendothelialization had occurred in the vessels that failed to show platelet deposition. Delayed healing was associated with continuing platelet deposition, excessive thrombus formation, and luminal stenosis. Arteriotomy closure with a vein patch altered the healing characteristics of the vessel with segmental thrombus formation over the vein patch. A preliminary study of the postendarterectomy in vivo In-111 platelet response in humans demonstrated platelet deposition that was not influenced by the administration of antiplatelet drugs at currently prescribed levels

  20. Evaluation of Extended Wall OSB Sheathing Connection under Combined Uplift and Shear Loading for 24-inch Heel Trusses

    Science.gov (United States)

    Vladimir Kochkin; Andrew DeRenzis; Xiping Wang

    2014-01-01

    This study was designed to evaluate the performance of the extended wall structural panel connection in resisting combined uplift and shear forces at the roof-to-wall interface with a focus on a truss heel height of 24 in. to address the expected increases in the depth of attic insulation used in Climate Zones 5 and higher. Five full-size roof-wall assemblies were...

  1. Acoustic emission monitoring during hydrotest of a thin wall pressure vessel

    International Nuclear Information System (INIS)

    Fontana, E.; Grugni, G.; Panzani, C.; Pirovano, B.; Possa, G.; Tonolini, F.

    1976-01-01

    Results are presented of the acoustic emission monitoring during hydrotests of a thin wall steel pressure vessel. Location of acoustic sources was based on longitudinal wave front detection. The careful calibration of the three sensors used for acoustic source location was found to be very useful, and allowed an accurate location error analysis. Acoustic emission in the hydrotests was found to be due mainly to stress release in weld seams

  2. Stress analysis of a double-wall vacuum vessel for ITER

    International Nuclear Information System (INIS)

    Conner, D.L.; Williamson, D.E.; Nelson, B.E.

    1991-01-01

    The preliminary structural analyses performed in support of the design of the vacuum vessel for the International Thermonuclear Experimental Reactor (ITER) are described. A thin, double-wall, all-welded structure is the proposed design concept analyzed. The results of the static stress analysis indicate the adequacy of such a structure. The effects of the proposed high-aspect-ratio design configuration on loading and stresses are also discussed. 4 refs., 6 figs., 1 tab

  3. Gadolinium Enhanced MR Coronary Vessel Wall Imaging at 3.0 Tesla

    Directory of Open Access Journals (Sweden)

    Sebastian Kelle

    2010-01-01

    Full Text Available Purpose. We evaluated the influence of the time between low-dose gadolinium (Gd contrast administration and coronary vessel wall enhancement (LGE detected by 3T magnetic resonance imaging (MRI in healthy subjects and patients with coronary artery disease (CAD. Materials and Methods. Four healthy subjects (4 men, mean age 29  ±  3 years and eleven CAD patients (6 women, mean age 61±10 years were studied on a commercial 3.0 Tesla (T whole-body MR imaging system (Achieva 3.0 T; Philips, Best, The Netherlands. T1-weighted inversion-recovery coronary magnetic resonance imaging (MRI was repeated up to 75 minutes after administration of low-dose Gadolinium (Gd (0.1 mmol/kg Gd-DTPA. Results. LGE was seen in none of the healthy subjects, however in all of the CAD patients. In CAD patients, fifty-six of 62 (90.3% segments showed LGE of the coronary artery vessel wall at time-interval 1 after contrast. At time-interval 2, 34 of 42 (81.0% and at time-interval 3, 29 of 39 evaluable segments (74.4% were enhanced. Conclusion. In this work, we demonstrate LGE of the coronary artery vessel wall using 3.0 T MRI after a single, low-dose Gd contrast injection in CAD patients but not in healthy subjects. In the majority of the evaluated coronary segments in CAD patients, LGE of the coronary vessel wall was already detectable 30–45 minutes after administration of the contrast agent.

  4. Pulsatility Index as a Diagnostic Parameter of Reciprocating Wall Shear Stress Parameters in Physiological Pulsating Waveforms.

    Directory of Open Access Journals (Sweden)

    Idit Avrahami

    Full Text Available Arterial wall shear stress (WSS parameters are widely used for prediction of the initiation and development of atherosclerosis and arterial pathologies. Traditional clinical evaluation of arterial condition relies on correlations of WSS parameters with average flow rate (Q and heart rate (HR measurements. We show that for pulsating flow waveforms in a straight tube with flow reversals that lead to significant reciprocating WSS, the measurements of HR and Q are not sufficient for prediction of WSS parameters. Therefore, we suggest adding a third quantity-known as the pulsatility index (PI-which is defined as the peak-to-peak flow rate amplitude normalized by Q. We examine several pulsating flow waveforms with and without flow reversals using a simulation of a Womersley model in a straight rigid tube and validate the simulations through experimental study using particle image velocimetry (PIV. The results indicate that clinically relevant WSS parameters such as the percentage of negative WSS (P[%], oscillating shear index (OSI and the ratio of minimum to maximum shear stress rates (min/max, are better predicted when the PI is used in conjunction with HR and Q. Therefore, we propose to use PI as an additional and essential diagnostic quantity for improved predictability of the reciprocating WSS.

  5. Reliability assessment and probability based design of reinforced concrete containments and shear walls

    International Nuclear Information System (INIS)

    Hwang, H.; Reich, M.; Ellingwood, B.; Shinozuka, M.

    1986-03-01

    This report summarizes work completed under the program entitled, ''Probability-Based Load Combinations for Design of Category I Structures.'' Under this program, the probabilistic models for various static and dynamic loads were formulated. The randomness and uncertainties in material strengths and structural resistance were established. Several limit states of concrete containments and shear walls were identified and analytically formulated. Furthermore, the reliability analysis methods for estimating limit state probabilities were established. These reliability analysis methods can be used to evaluate the safety levels of nuclear structures under various combinations of static and dynamic loads. They can also be used to generate analytically the fragility data for PRA studies. In addition to the development of reliability analysis methods, probability-based design criteria for concrete containments and shear wall structures have also been developed. The proposed design criteria are in the load and resistance factor design (LRFD) format. The load and resistance factors are determined for several limit states and target limit state probabilities. Thus, the proposed design criteria are risk-consistent and have a well-established rationale. 73 refs., 18 figs., 16 tabs

  6. Substructure hybrid testing of reinforced concrete shear wall structure using a domain overlapping technique

    Science.gov (United States)

    Zhang, Yu; Pan, Peng; Gong, Runhua; Wang, Tao; Xue, Weichen

    2017-10-01

    An online hybrid test was carried out on a 40-story 120-m high concrete shear wall structure. The structure was divided into two substructures whereby a physical model of the bottom three stories was tested in the laboratory and the upper 37 stories were simulated numerically using ABAQUS. An overlapping domain method was employed for the bottom three stories to ensure the validity of the boundary conditions of the superstructure. Mixed control was adopted in the test. Displacement control was used to apply the horizontal displacement, while two controlled force actuators were applied to simulate the overturning moment, which is very large and cannot be ignored in the substructure hybrid test of high-rise buildings. A series of tests with earthquake sources of sequentially increasing intensities were carried out. The test results indicate that the proposed hybrid test method is a solution to reproduce the seismic response of high-rise concrete shear wall buildings. The seismic performance of the tested precast high-rise building satisfies the requirements of the Chinese seismic design code.

  7. Notch1 and 4 Signaling Responds to an Increasing Vascular Wall Shear Stress in a Rat Model of Arteriovenous Malformations

    Directory of Open Access Journals (Sweden)

    Jian Tu

    2014-01-01

    Full Text Available Notch signaling is suggested to promote the development and maintenance of cerebral arteriovenous malformations (AVMs, and an increasing wall shear stress (WSS contributes to AVM rupture. Little is known about whether WSS impacts Notch signaling, which is important for understanding the angiogenesis of AVMs. WSS was measured in arteriovenous fistulas (AVF surgically created in 96 rats at different time points over a period of 84 days. The expression of Notch receptors 1 and 4 and their ligands, Delta1 and 4, Jagged1, and Notch downstream gene target Hes1 was quantified in “nidus” vessels. The interaction events between Notch receptors and their ligands were quantified using proximity ligation assay. There was a positive correlation between WSS and time (r=0.97; P<0.001. The expression of Notch receptors and their ligands was upregulated following AVF formation. There was a positive correlation between time and the number of interactions between Notch receptors and their ligands aftre AVF formation (r=0.62, P<0.05 and a positive correlation between WSS and the number of interactions between Notch receptors and their ligands (r=0.87, P<0.005. In conclusion, an increasing WSS may contribute to the angiogenesis of AVMs by activation of Notch signaling.

  8. PEG-albumin plasma expansion increases expression of MCP-1 evidencing increased circulatory wall shear stress: an experimental study.

    Directory of Open Access Journals (Sweden)

    C Makena Hightower

    Full Text Available Treatment of blood loss with plasma expanders lowers blood viscosity, increasing cardiac output. However, increased flow velocity by conventional plasma expanders does not compensate for decreased viscosity in maintaining vessel wall shear stress (WSS, decreasing endothelial nitric oxide (NO production. A new type of plasma expander using polyethylene glycol conjugate albumin (PEG-Alb causes supra-perfusion when used in extreme hemodilution and is effective in treating hemorrhagic shock, although it is minimally viscogenic. An acute 40% hemodilution/exchange-transfusion protocol was used to compare 4% PEG-Alb to Ringer's lactate, Dextran 70 kDa and 6% Hetastarch (670 kDa in unanesthetized CD-1 mice. Serum cytokine analysis showed that PEG-Alb elevates monocyte chemotactic protein-1 (MCP-1, a member of a small inducible gene family, as well as expression of MIP-1α, and MIP-2. MCP-1 is specific to increased WSS. Given the direct link between increased WSS and production of NO, the beneficial resuscitation effects due to PEG-Alb plasma expansion appear to be due to increased WSS through increased perfusion and blood flow rather than blood viscosity.

  9. High-resolution vessel wall MRI for the evaluation of intracranial atherosclerotic disease

    Energy Technology Data Exchange (ETDEWEB)

    De Havenon, Adam [University of Utah, Department of Neurology, Salt Lake City, UT (United States); Mossa-Basha, Mahmud [University of Washington, Department of Radiology, Seattle, WA (United States); Shah, Lubdha; Kim, Seong-Eun; Parker, Dennis; McNally, J.S. [University of Utah, Department of Radiology, Salt Lake City, UT (United States); Park, Min [University of Utah, Department of Neurosurgery, Salt Lake City, UT (United States)

    2017-12-15

    High-resolution vessel wall MRI (vwMRI) of the intracranial arteries is an emerging diagnostic imaging technique with the goal of evaluating vascular pathology. vwMRI sequences have high spatial resolution and directly image the vessel wall by suppressing blood signal. With vwMRI, it is possible to identify distinct morphologic and enhancement patterns of atherosclerosis that can provide important information about stroke etiology and recurrence risk. We present a review of vwMRI research in relation to intracranial atherosclerosis, with a focus on the relationship between ischemic stroke and atherosclerotic plaque T1 post-contrast enhancement or plaque/vessel wall morphology. The goal of this review is to provide readers with the most current understanding of the reliability, incidence, and importance of specific vwMRI findings in intracranial atherosclerosis, to guide their interpretation of vwMRI research, and help inform clinical interpretation of vwMRI. We will also provide a translational perspective on the existing vwMRI literature and insight into future vwMRI research questions and objectives. With increased use of high field strength MRI, powerful gradients, and improved pulse sequences, vwMRI will become standard-of-care in the diagnosis and prognosis of patients with cerebrovascular disease, making a firm grasp of its strengths and weakness important for neuroimagers. (orig.)

  10. Regulation of cellular communication by signaling microdomains in the blood vessel wall.

    Science.gov (United States)

    Billaud, Marie; Lohman, Alexander W; Johnstone, Scott R; Biwer, Lauren A; Mutchler, Stephanie; Isakson, Brant E

    2014-01-01

    It has become increasingly clear that the accumulation of proteins in specific regions of the plasma membrane can facilitate cellular communication. These regions, termed signaling microdomains, are found throughout the blood vessel wall where cellular communication, both within and between cell types, must be tightly regulated to maintain proper vascular function. We will define a cellular signaling microdomain and apply this definition to the plethora of means by which cellular communication has been hypothesized to occur in the blood vessel wall. To that end, we make a case for three broad areas of cellular communication where signaling microdomains could play an important role: 1) paracrine release of free radicals and gaseous molecules such as nitric oxide and reactive oxygen species; 2) role of ion channels including gap junctions and potassium channels, especially those associated with the endothelium-derived hyperpolarization mediated signaling, and lastly, 3) mechanism of exocytosis that has considerable oversight by signaling microdomains, especially those associated with the release of von Willebrand factor. When summed, we believe that it is clear that the organization and regulation of signaling microdomains is an essential component to vessel wall function.

  11. Regulation of Cellular Communication by Signaling Microdomains in the Blood Vessel Wall

    Science.gov (United States)

    Billaud, Marie; Lohman, Alexander W.; Johnstone, Scott R.; Biwer, Lauren A.; Mutchler, Stephanie; Isakson, Brant E.

    2014-01-01

    It has become increasingly clear that the accumulation of proteins in specific regions of the plasma membrane can facilitate cellular communication. These regions, termed signaling microdomains, are found throughout the blood vessel wall where cellular communication, both within and between cell types, must be tightly regulated to maintain proper vascular function. We will define a cellular signaling microdomain and apply this definition to the plethora of means by which cellular communication has been hypothesized to occur in the blood vessel wall. To that end, we make a case for three broad areas of cellular communication where signaling microdomains could play an important role: 1) paracrine release of free radicals and gaseous molecules such as nitric oxide and reactive oxygen species; 2) role of ion channels including gap junctions and potassium channels, especially those associated with the endothelium-derived hyperpolarization mediated signaling, and lastly, 3) mechanism of exocytosis that has considerable oversight by signaling microdomains, especially those associated with the release of von Willebrand factor. When summed, we believe that it is clear that the organization and regulation of signaling microdomains is an essential component to vessel wall function. PMID:24671377

  12. High-resolution vessel wall MRI for the evaluation of intracranial atherosclerotic disease

    International Nuclear Information System (INIS)

    De Havenon, Adam; Mossa-Basha, Mahmud; Shah, Lubdha; Kim, Seong-Eun; Parker, Dennis; McNally, J.S.; Park, Min

    2017-01-01

    High-resolution vessel wall MRI (vwMRI) of the intracranial arteries is an emerging diagnostic imaging technique with the goal of evaluating vascular pathology. vwMRI sequences have high spatial resolution and directly image the vessel wall by suppressing blood signal. With vwMRI, it is possible to identify distinct morphologic and enhancement patterns of atherosclerosis that can provide important information about stroke etiology and recurrence risk. We present a review of vwMRI research in relation to intracranial atherosclerosis, with a focus on the relationship between ischemic stroke and atherosclerotic plaque T1 post-contrast enhancement or plaque/vessel wall morphology. The goal of this review is to provide readers with the most current understanding of the reliability, incidence, and importance of specific vwMRI findings in intracranial atherosclerosis, to guide their interpretation of vwMRI research, and help inform clinical interpretation of vwMRI. We will also provide a translational perspective on the existing vwMRI literature and insight into future vwMRI research questions and objectives. With increased use of high field strength MRI, powerful gradients, and improved pulse sequences, vwMRI will become standard-of-care in the diagnosis and prognosis of patients with cerebrovascular disease, making a firm grasp of its strengths and weakness important for neuroimagers. (orig.)

  13. Evaluation of Aortic Blood Flow and Wall Shear Stress in Aortic Stenosis and Its Association With Left Ventricular Remodeling

    Science.gov (United States)

    von Knobelsdorff-Brenkenhoff, Florian; Karunaharamoorthy, Achudhan; Trauzeddel, Ralf Felix; Barker, Alex J; Blaszczyk, Edyta; Markl, Michael; Schulz-Menger, Jeanette

    2016-01-01

    Background Aortic stenosis (AS) leads to variable stress for the left ventricle (LV) and consequently a broad range of LV remodeling. Study aim was to describe blood flow patterns in the ascending aorta of AS patients and determine their association with remodeling. Methods and Results Thirty-seven patients with AS (14 mild, 8 moderate, 15 severe; age 63±13 years) and 37 healthy controls (age 60±10 years) underwent 4D-flow MRI. Helical and vortical flow formations and flow eccentricity were assessed in the ascending aorta. Normalized flow displacement from the vessel center and peak systolic wall shear stress (WSSpeak) in the ascending aorta were quantified. LV remodeling was assessed based on LV mass index (LVMI-I) and the ratio of LV mass to enddiastolic volume (relative wall mass; RWM). Marked helical and vortical flow formation and eccentricity were more prevalent in patients with AS than in healthy subjects, and AS patients exhibited an asymmetric and elevated distribution of WSSpeak. In AS, aortic orifice area was strongly negatively associated with vortical flow formation (p=0.0274), eccentricity (p=0.0070) and flow displacement (p=0.0021). Bicuspid aortic valve was associated with more intense helical (p=0.0098) and vortical flow formation (p=0.0536), higher flow displacement (p=0.11) and higher WSSpeak (p=0.0926). LVM-I and RWM were significantly associated with aortic orifice area (p=0.0611, p=0.0058) and flow displacement (p=0.0058, p=0.0283). Conclusions In this pilot study, AS leads to abnormal blood flow pattern and WSSpeak in the ascending aorta. In addition to aortic orifice area, normalized flow displacement was significantly associated with LV remodeling. PMID:26917824

  14. Role of 3.0 T MR vessel wall imaging for identifying the activity of takayasu arteritis

    International Nuclear Information System (INIS)

    Liu Xiaosheng; Xu Jianrong; Zhao Huilin; Cheng Fang; Lu Qing; Yao Qiuying

    2010-01-01

    Objective: To analyze and explore the value of 3 T high resolution magnetic resonance vessel wall imaging for identifying the activity of Takayasu arteritis. Methods: Twenty-six consecutive patients with Takayasu arteritis underwent 3.0 T high resolution MR vessel wall imaging on supraortic vessels (according to the classification of Lupi-Herrea, type I and III were included). Sixteen patients were in active phase and 10 in inactive phase based on the Kerr criteria. The MR vessel wall imaging appearances of Takayasu arteritis were compared between the active phase and inactive phase cases. Results: Wall thickening was demonstrated in all involved arteries. There were statistically significant differences between active phase and inactive phase cases in MR appearances including multi-ring thickening of vessel wall (75/80 and 18/50), arterial inner wail enhancement (50/80 and 19/50), obscurity of perivascular fat (55/80 and 18/50, X 2 =50.39, 7.41, 13.40, P<0.01). There was also a statistically significant difference in the thickness of carotid artery wall between the two groups [ (3.8 ± 0.2) mm vs (2.5 ± 0.8) mm]. Conclusion: 3 T high resolution MR vessel wall imaging is valuable for identifying the activity of Takayasu arteritis. (authors)

  15. Primary Metabolism during Biosynthesis of Secondary Wall Polymers of Protoxylem Vessel Elements1[OPEN

    Science.gov (United States)

    Morisaki, Keiko; Sawada, Yuji; Sano, Ryosuke; Yamamoto, Atsushi; Kurata, Tetsuya; Suzuki, Shiro; Matsuda, Mami; Hasunuma, Tomohisa; Hirai, Masami Yokota

    2016-01-01

    Xylem vessels, the water-conducting cells in vascular plants, undergo characteristic secondary wall deposition and programmed cell death. These processes are regulated by the VASCULAR-RELATED NAC-DOMAIN (VND) transcription factors. Here, to identify changes in metabolism that occur during protoxylem vessel element differentiation, we subjected tobacco (Nicotiana tabacum) BY-2 suspension culture cells carrying an inducible VND7 system to liquid chromatography-mass spectrometry-based wide-target metabolome analysis and transcriptome analysis. Time-course data for 128 metabolites showed dynamic changes in metabolites related to amino acid biosynthesis. The concentration of glyceraldehyde 3-phosphate, an important intermediate of the glycolysis pathway, immediately decreased in the initial stages of cell differentiation. As cell differentiation progressed, specific amino acids accumulated, including the shikimate-related amino acids and the translocatable nitrogen-rich amino acid arginine. Transcriptome data indicated that cell differentiation involved the active up-regulation of genes encoding the enzymes catalyzing fructose 6-phosphate biosynthesis from glyceraldehyde 3-phosphate, phosphoenolpyruvate biosynthesis from oxaloacetate, and phenylalanine biosynthesis, which includes shikimate pathway enzymes. Concomitantly, active changes in the amount of fructose 6-phosphate and phosphoenolpyruvate were detected during cell differentiation. Taken together, our results show that protoxylem vessel element differentiation is associated with changes in primary metabolism, which could facilitate the production of polysaccharides and lignin monomers and, thus, promote the formation of the secondary cell wall. Also, these metabolic shifts correlate with the active transcriptional regulation of specific enzyme genes. Therefore, our observations indicate that primary metabolism is actively regulated during protoxylem vessel element differentiation to alter the cell’s metabolic

  16. PIV Measurement of Wall Shear Stress and Flow Structures within an Intracranial Aneurysm Model

    Science.gov (United States)

    Chow, Ricky; Sparrow, Eph; Campbell, Gary; Divani, Afshin; Sheng, Jian

    2012-11-01

    The formation and rupture of an intracranial aneurysm (IA) is a debilitating and often lethal event. Geometric features of the aneurysm bulb and upstream artery, such as bulb size, bulb shape, and curvature of the artery, are two groups of factors that define the flow and stresses within an IA. Abnormal flow stresses are related to rupture. This presentation discusses the development of a quasi-3D PIV technique and its application in various glass models at Re = 275 and 550 to experimentally assess at a preliminary level the impact of geometry and flow rate. Some conclusions are to be drawn linking geometry of the flow domain to rupture risk. The extracted results also serve as the baseline case and as a precursor to a companion presentation by the authors discussing the impact of flow diverters, a new class of medical devices. The PIV experiments were performed in a fully index-matched flow facility, allowing for unobstructed observations over complex geometry. A reconstruction and analysis method was devised to obtain 3D mean wall stress distributions and flow fields. The quasi 3D measurements were reconstructed from orthogonal planes encompassing the entire glass model, spaced 0.4mm apart. Wall shear stresses were evaluated from the near-wall flow viscous stresses.

  17. Sensitivity of Variables with Time for Degraded RC Shear Wall with Low Steel Ratio under Seismic Load

    International Nuclear Information System (INIS)

    Park, Jun Hee; Choun, Young Sun; Choi, In Kil

    2011-01-01

    Various factors lead to the degradation of reinforced concrete (RC) shear wall over time. The steel section loss, concrete spalling and strength of material have been considered for the structural analysis of degraded shear wall. When all variables with respect to degradation are considered for probabilistic evaluation of degraded shear wall, many of time and effort were demanded. Therefore, it is required to define important variables related to structural behavior for effectively conducting probabilistic seismic analysis of structures with age-related degradation. In this study, variables were defined by applying the function of time to consider degradation with time. Importance of variables with time on the seismic response was investigated by conducting sensitivity analysis

  18. Freezing resistance in Patagonian woody shrubs: the role of cell wall elasticity and stem vessel size.

    Science.gov (United States)

    Zhang, Yong-Jiang; Bucci, Sandra J; Arias, Nadia S; Scholz, Fabian G; Hao, Guang-You; Cao, Kun-Fang; Goldstein, Guillermo

    2016-08-01

    Freezing resistance through avoidance or tolerance of extracellular ice nucleation is important for plant survival in habitats with frequent subzero temperatures. However, the role of cell walls in leaf freezing resistance and the coordination between leaf and stem physiological processes under subzero temperatures are not well understood. We studied leaf and stem responses to freezing temperatures, leaf and stem supercooling, leaf bulk elastic modulus and stem xylem vessel size of six Patagonian shrub species from two sites (plateau and low elevation sites) with different elevation and minimum temperatures. Ice seeding was initiated in the stem and quickly spread to leaves, but two species from the plateau site had barriers against rapid spread of ice. Shrubs with xylem vessels smaller in diameter had greater stem supercooling capacity, i.e., ice nucleated at lower subzero temperatures. Only one species with the lowest ice nucleation temperature among all species studied exhibited freezing avoidance by substantial supercooling, while the rest were able to tolerate extracellular freezing from -11.3 to -20 °C. Leaves of species with more rigid cell walls (higher bulk elastic modulus) could survive freezing to lower subzero temperatures, suggesting that rigid cell walls potentially reduce the degree of physical injury to cell membranes during the extracellular freezing and/or thaw processes. In conclusion, our results reveal the temporal-spatial ice spreading pattern (from stem to leaves) in Patagonian shrubs, and indicate the role of xylem vessel size in determining supercooling capacity and the role of cell wall elasticity in determining leaf tolerance of extracellular ice formation. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  19. Impact of vessel wall lesions and vascular stenoses on cerebrovascular reactivity in patients with intracranial stenotic disease

    NARCIS (Netherlands)

    Cogswell, Petrice M; Davis, Taylor L; Strother, Megan K; Faraco, Carlos C; Scott, Allison O; Jordan, Lori C; Fusco, Matthew R; Frederick, Blaise deB; Hendrikse, Jeroen; Donahue, Manus J

    2017-01-01

    PURPOSE: To compare cerebrovascular reactivity (CVR) and CVR lagtimes in flow territories perfused by vessels with vs. without proximal arterial wall disease and/or stenosis, separately in patients with atherosclerotic and nonatherosclerotic (moyamoya) intracranial stenosis. MATERIALS AND METHODS:

  20. Direct measurements of wall shear stress by buried wire gages in a shock-wave boundary-layer interaction region

    Science.gov (United States)

    Murthy, V. S.; Rose, W. C.

    1977-01-01

    Detailed measurements of wall shear stress (skin friction) were made with specially developed buried wire gages in the interaction regions of a Mach 2.9 turbulent boundary layer with externally generated shocks. Separation and reattachment points inferred by these measurements support the findings of earlier experiments which used a surface oil flow technique and pitot profile measurements. The measurements further indicate that the boundary layer tends to attain significantly higher skin-friction values downstream of the interaction region as compared to upstream. Comparisons between measured wall shear stress and published results of some theoretical calculation schemes show that the general, but not detailed, behavior is predicted well by such schemes.

  1. Interaction between a normal shock wave and a turbulent boundary layer at high transonic speeds. II - Wall shear stress

    Science.gov (United States)

    Liou, M. S.; Adamson, T. C., Jr.

    1980-01-01

    Asymptotic methods are used to calculate the shear stress at the wall for the interaction between a normal shock wave and a turbulent boundary layer on a flat plate. A mixing length model is used for the eddy viscosity. The shock wave is taken to be strong enough that the sonic line is deep in the boundary layer and the upstream influence is thus very small. It is shown that unlike the result found for laminar flow an asymptotic criterion for separation is not found; however, conditions for incipient separation are computed numerically using the derived solution for the shear stress at the wall. Results are compared with available experimental measurements.

  2. Positive association between increased popliteal artery vessel wall thickness and generalized osteoarthritis: is OA also part of the metabolic syndrome?

    International Nuclear Information System (INIS)

    Kornaat, Peter R.; Sharma, Ruby; Geest, Rob J. van der; Lamb, Hildo J.; Bloem, Johan L.; Watt, Iain; Kloppenburg, Margreet; Hellio le Graverand, Marie-Pierre

    2009-01-01

    The purpose of the study was to determine if a positive association exists between arterial vessel wall thickness and generalized osteoarthritis (OA). Our hypothesis is that generalized OA is another facet of the metabolic syndrome. The medical ethical review board of our institution approved the study. Written informed consent was obtained from each patient prior to the study. Magnetic resonance (MR) images of the knee were obtained in 42 patients who had been diagnosed with generalized OA at multiple joint sites. Another 27 MR images of the knee were obtained from a matched normal (non-OA) reference population. Vessel wall thickness of the popliteal artery was quantitatively measured by dedicated software. Linear regression models were used to investigate the association between vessel wall thickness and generalized OA. Adjustments were made for age, sex, and body mass index (BMI). Confidence intervals (CI) were computed at the 95% level and a significance level of α = 0.05 was used. Patients in the generalized OA population had a significant higher average vessel wall thickness than persons from the normal reference population (p ≤ α), even when correction was made for sex, age, and BMI. The average vessel wall thickness of the popliteal artery was 1.09 mm in patients with generalized OA, and 0.96 mm in the matched normal reference population. The association found between increased popliteal artery vessel wall thickness and generalized osteoarthritis suggests that generalized OA might be another facet of the metabolic syndrome. (orig.)

  3. Positive association between increased popliteal artery vessel wall thickness and generalized osteoarthritis: is OA also part of the metabolic syndrome?

    Energy Technology Data Exchange (ETDEWEB)

    Kornaat, Peter R.; Sharma, Ruby; Geest, Rob J. van der; Lamb, Hildo J.; Bloem, Johan L.; Watt, Iain [Leiden University Medical Center, Department of Radiology, Leiden (Netherlands); Kloppenburg, Margreet [Leiden University Medical Center, Department of Rheumatology, Leiden (Netherlands); Hellio le Graverand, Marie-Pierre [Pfizer Global Research and Development, New London, CT (United States)

    2009-12-15

    The purpose of the study was to determine if a positive association exists between arterial vessel wall thickness and generalized osteoarthritis (OA). Our hypothesis is that generalized OA is another facet of the metabolic syndrome. The medical ethical review board of our institution approved the study. Written informed consent was obtained from each patient prior to the study. Magnetic resonance (MR) images of the knee were obtained in 42 patients who had been diagnosed with generalized OA at multiple joint sites. Another 27 MR images of the knee were obtained from a matched normal (non-OA) reference population. Vessel wall thickness of the popliteal artery was quantitatively measured by dedicated software. Linear regression models were used to investigate the association between vessel wall thickness and generalized OA. Adjustments were made for age, sex, and body mass index (BMI). Confidence intervals (CI) were computed at the 95% level and a significance level of {alpha} = 0.05 was used. Patients in the generalized OA population had a significant higher average vessel wall thickness than persons from the normal reference population (p {<=} {alpha}), even when correction was made for sex, age, and BMI. The average vessel wall thickness of the popliteal artery was 1.09 mm in patients with generalized OA, and 0.96 mm in the matched normal reference population. The association found between increased popliteal artery vessel wall thickness and generalized osteoarthritis suggests that generalized OA might be another facet of the metabolic syndrome. (orig.)

  4. Elasto-plastic response of multi-story shear wall structures

    International Nuclear Information System (INIS)

    Mizutani, M.; Yamazaki, F.

    1987-01-01

    A Monte Carlo simulation study is carried out. The relationship between the elastoplastic and linear response for multi-DOF systems is developed based on the results of the simulation study. Several 6-story shear wall structures are considered as structural models which represent typical nuclear power plant buildings. A bilinear force-displacement relationship is assumed for each story. A number of artificial earthquakes based on the Kanai-Tajimi power spectrum and trapezoidal envelope function are used as the input ground motion. The least square method is introduced for the purpose of evaluating the median relationship between the ductility factor and linear response from the simulated data and also evaluating the deviation from this median relationship. This relationship derived for the 6-story buildings is compared with the currently used energy absorption factor and the simulation results for Zion auxiliary building model. (orig./HP)

  5. Experimental investigation into the seismic behavior of nuclear power plant shear wall structures

    International Nuclear Information System (INIS)

    Kenneally, R.M.; Burns, J.J. Jr.

    1988-01-01

    Nuclear power plant structures are designed to resist large earthquakes. However, as new data are obtained on earthquake activity throughout the United States, plant design earthquake levels have increased. The U.S. Nuclear Regulatory Commission is sponsoring an analytical-experimental research program to obtain information on the strucutral response of nuclear power plant shear wall strucutres subjected to earthquake motions within and beyond their design basis. Using different size scale models constructed with microconcrete and prototypical concrete this research has demonstrated consistent results for measured values of stiffness at load levels within the design basis. Furthermore, the values are well below the theoretical stiffnesses calculated from an uncracked cross-section strength-of-materials approach. Current program emphasis is to assess the credibility of previous experimental work by beginning to resolve the 'stiffness difference' issue. (orig.)

  6. Wall Shear Stress Estimation of Thoracic Aortic Aneurysm Using Computational Fluid Dynamics

    Directory of Open Access Journals (Sweden)

    J. Febina

    2018-01-01

    Full Text Available An attempt has been made to evaluate the effects of wall shear stress (WSS on thoracic aortic aneurysm (TAA using Computational Fluid Dynamics (CFD. Aneurysm is an excessive localized swelling of the arterial wall due to many physiological factors and it may rupture causing shock or sudden death. The existing imaging modalities such as MRI and CT assist in the visualization of anomalies in internal organs. However, the expected dynamic behaviour of arterial bulge under stressed condition can only be effectively evaluated through mathematical modelling. In this work, a 3D aneurysm model is reconstructed from the CT scan slices and eventually the model is imported to Star CCM+ (Siemens, USA for intensive CFD analysis. The domain is discretized using polyhedral mesh with prism layers to capture the weakening boundary more accurately. When there is flow reversal in TAA as seen in the velocity vector plot, there is a chance of cell damage causing clots. This is because of the shear created in the system due to the flow pattern. It is observed from the proposed mathematical modelling that the deteriorating WSS is an indicator for possible rupture and its value oscillates over a cardiac cycle as well as over different stress conditions. In this model, the vortex formation pattern and flow reversals are also captured. The non-Newtonian model, including a pulsatile flow instead of a steady average flow, does not overpredict the WSS (15.29 Pa compared to 16 Pa for the Newtonian model. Although in a cycle the flow behaviour is laminar-turbulent-laminar (LTL, utilizing the non-Newtonian model along with LTL model also overpredicted the WSS with a value of 20.1 Pa. The numerical study presented here provides good insight of TAA using a systematic approach to numerical modelling and analysis.

  7. A compression and shear loading test of concrete filled steel bearing wall

    International Nuclear Information System (INIS)

    Akiyama, Hiroshi; Sekimoto, Hisashi; Fukihara, Masaaki; Nakanishi, Kazuo; Hara, Kiyoshi.

    1991-01-01

    Concrete-filled steel bearing walls called SC structure which are the composite structure of concrete and steel plates have larger load-carrying capacity and higher ductility as compared with conventional RC structures, and their construction method enables the rationalization of construction procedures at sites and the shortening of construction period. Accordingly, the SC structures have become to be applied to the inner concrete structures of PWR nuclear power plants, and subsequently, it is planned to apply them to the auxiliary buildings of nuclear power plants. The purpose of this study is to establish a rational design method for the SC structures which can be applied to the auxiliary buildings of nuclear power plants. In this study, the buckling strength of surface plates and the ultimate strength of the SC structure were evaluated with the results of the compression and shear tests which have been carried out. The outline of the study and the tests, the results of the compression test and the shear test and their evaluation are reported. Stud bolts were effective for preventing the buckling of surface plates. The occurrence of buckling can be predicted analytically. (K.I.)

  8. Tearing stability analysis of an axial surface flaw in thick-walled pressure vessels

    International Nuclear Information System (INIS)

    Zahoor, A.; Ghassemi, B.B.

    1991-01-01

    This paper presents two fracture mechanics models for evaluation of an axial surface flaw in pressure vessels. The surface flaw is located on the outside surface of the vessel. The first model assumes yielding of the remaining ligament directly ahead of the flaw. The second model assumes contained yielding ahead of the flaw and uses a linear elastic fracture mechanics solution. The former model is suitable for cases where the combination of material toughness, flaw size, and load is such that initiation of flaw growth follows ligament yielding. The latter model is suitable for low-toughness materials where initiation of crack growth and potential tearing instability may occur prior to the yielding of the ligament. Both models are suitable for thick-walled vessels. The paper discusses the applicability regime for both models. The models are then applied to a test vessel and the predicted failure pressure is compared against the pressure attained in the test. Results show that both models can be applied successfully. In particular, the contained yielding model when used with the plane-stress assumption can give reasonable predictions even for cases that involve yielding of the ligament. (orig.)

  9. Tearing stability analysis of an axial surface flaw in thick-walled pressure vessels

    Energy Technology Data Exchange (ETDEWEB)

    Zahoor, A.; Ghassemi, B.B. (NOVETECH Corp., Rockville, MD (USA))

    1991-04-01

    This paper presents two fracture mechanics models for evaluation of an axial surface flaw in pressure vessels. The surface flaw is located on the outside surface of the vessel. The first model assumes yielding of the remaining ligament directly ahead of the flaw. The second model assumes contained yielding ahead of the flaw and uses a linear elastic fracture mechanics solution. The former model is suitable for cases where the combination of material toughness, flaw size, and load is such that initiation of flaw growth follows ligament yielding. The latter model is suitable for low-toughness materials where initiation of crack growth and potential tearing instability may occur prior to the yielding of the ligament. Both models are suitable for thick-walled vessels. The paper discusses the applicability regime for both models. The models are then applied to a test vessel and the predicted failure pressure is compared against the pressure attained in the test. Results show that both models can be applied successfully. In particular, the contained yielding model when used with the plane-stress assumption can give reasonable predictions even for cases that involve yielding of the ligament. (orig.).

  10. In vivo and in vitro methods to study platelet adhesion to the components of the vessel wall

    International Nuclear Information System (INIS)

    Cazenave, J.-P.

    1979-01-01

    The methods that are used to measure platelet adhesion can be divided in five groups: methods that use an aggregometer to measure platelet adhesion to collagen in the presence of EDTA; methods that use binding of radiolabeled collagen, affinity chromatography, or gel filtration; the morphometric method of Baumgartner that measures platelet interaction with the subendothelium of an aorta exposed to flow in an annular perfusion chamber; the quantitative isotopic measurement of platelet adhesion to collagen-coated surfaces and to subendothelium with the rotating probe device of Cazenave; and in vivo platelet adhesion to the subendothelium measured by the morphometric method or with platelets radiolabeled with 51 Cr or 111 In. With these methods it has been possible to study the factors (Ca 2+ ; VIII: von Willebrand factor; hemodynamic factors: red cells, shear rate; components of the vessel wall) governing platelet adhesion to subendothelium and to collagen. It has also been possible to screen and study drugs inhibiting platelet adhesion, which is the first step in the formation of a thrombus at the site of vascular injury [fr

  11. Applied model of through-wall crack of coolant vessels of WWER-type reactors

    International Nuclear Information System (INIS)

    Petrosyan, V.; Hovakimyan, T.; Vardanyan, M.; Khachatryan, A.; Minasyan, K.

    2010-01-01

    We propose an applied-model of Through-Wall Crack (TWC) for WWER-type units primary vessels. The model allows to simulate the main morphological parameters of real TWC, i.e. length, area of inlet and outlet openings, channel depth and small and large size unevenness of the crack surface. The model can be used for developing and improving the coolant-leak detectors for the primary circuit vessels of WWER-units. Also, it can be used for research of the coolant two-phase leakage phenomenon through narrow cracks/channels and thermo-physical processes in heat-insulation layer of the Main Coolant Piping (MCP) during the leak

  12. Upper and Lower Bound Limit Loads for Thin-Walled Pressure Vessels Used for Aerosol Cans

    Directory of Open Access Journals (Sweden)

    Stephen John Hardy

    2009-01-01

    Full Text Available The elastic compensation method proposed by Mackenzie and Boyle is used to estimate the upper and lower bound limit (collapse loads for one-piece aluminium aerosol cans, which are thin-walled pressure vessels subjected to internal pressure loading. Elastic-plastic finite element predictions for yield and collapse pressures are found using axisymmetric models. However, it is shown that predictions for the elastic-plastic buckling of the vessel base require the use of a full three-dimensional model with a small unsymmetrical imperfection introduced. The finite element predictions for the internal pressure to cause complete failure via collapse fall within the upper and lower bounds. Hence the method, which involves only elastic analyses, can be used in place of complex elastic-plastic finite element analyses when upper and lower bound estimates are adequate for design purposes. Similarly, the lower bound value underpredicts the pressure at which first yield occurs.

  13. Seismic and Power Generation Performance of U-Shaped Steel Connected PV-Shear Wall under Lateral Cyclic Loading

    OpenAIRE

    Zhang, Hongmei; Dong, Jinzhi; Duan, Yuanfeng; Lu, Xilin; Peng, Jinqing

    2014-01-01

    BIPV is now widely used in office and residential buildings, but its seismic performance still remained vague especially when the photovoltaic (PV) modules are installed on high-rise building facades. A new form of reinforced concrete shear wall integrated with photovoltaic module is proposed in this paper, aiming to apply PV module to the facades of high-rise buildings. In this new form, the PV module is integrated with the reinforced concrete wall by U-shaped steel connectors through embedd...

  14. Numerical Analysis of Carbon Fiber Reinforced Plastic (CFRP Shear Walls and Steel Strips under Cyclic Loads Using Finite Element Method

    Directory of Open Access Journals (Sweden)

    N. Askarizadeh

    2017-12-01

    Full Text Available Reinforced concrete shear walls are the main elements of resistance against lateral loads in reinforced concrete structures. These walls should not only provide sufficient resistance but also provide sufficient ductility in order to avoid brittle fracture, particularly under strong seismic loads. However, many reinforced concrete shear walls need to be stabilized and reinforced due to various reasons such as changes in requirements of seismic regulations, weaknesses in design and execution, passage of time, damaging environmental factors, patch of rebar in plastic hinges and in some cases failures and weaknesses caused by previous earthquakes or explosion loads. Recently, Fiber Reinforced Polymer (FRP components have been extensively and successfully used in seismic improvement. This study reinforces FRP reinforced concrete shear walls and steel strips. CFRP and steel strips are evaluated by different yield and ultimate strength. Numerical and experimental studies are done on walls with scale 1/2. These walls are exposed to cyclic loading. Hysteresis curves of force, drift and strain of FRP strips are reviewed in order to compare results of numerical work and laboratory results. Both numerical and laboratory results show that CFRP and steel strips increase resistance, capacity and ductility of the structure.

  15. Acoustic emission monitoring during hydrotests of a thin wall pressure vessel

    International Nuclear Information System (INIS)

    Fontana, E.; Grugni, G.; Panzani, C.; Pirovano, B.; Possa, G.; Tonolini, F.

    1975-01-01

    The results are presented of an acoustic emission monitoring performed during hydrotests of a thin wall steel pressure vessel. The location of acoustic sources was based on longitudinal wave front detection. The careful calibration of the three sensors instrumentation system used for acoustic source location was found to be useful, and alllowed an accurate location error analysis. Acoustic emission in the hydrotests was found to be mainly due to stress release in weld seams. (Fontana, E.; Grugni, G.; Panzani, C.; Pirovano, B.; Possa, G.; Tonolini, F.)

  16. Remote through-wall sampling of the Trawsfynydd reactor pressure vessel: an overview

    International Nuclear Information System (INIS)

    Curry, A.; Clayton, R.

    1996-01-01

    This paper summarises the application of robotic equipment for gaining access to and removing through-wall samples from welds of the reactor pressure vessel at Trawsfynydd power station. The environment, which presents hazards due to ionising radiation, radioactive contamination and asbestos bearing materials is described. The means of access, by use of remote vehicles complete with robotic manipulators supported by additional vehicles, is reviewed. The use of Abrasive Water Jet Cutting for sample removal is introduced. The relative advantages and disadvantages of this technique are discussed. (Author)

  17. Carotid Intraplaque Hemorrhage Imaging with Quantitative Vessel Wall T1 Mapping: Technical Development and Initial Experience.

    Science.gov (United States)

    Qi, Haikun; Sun, Jie; Qiao, Huiyu; Chen, Shuo; Zhou, Zechen; Pan, Xinlei; Wang, Yishi; Zhao, Xihai; Li, Rui; Yuan, Chun; Chen, Huijun

    2018-04-01

    Purpose To develop a three-dimensional (3D) high-spatial-resolution time-efficient sequence for use in quantitative vessel wall T1 mapping. Materials and Methods A previously described sequence, simultaneous noncontrast angiography and intraplaque hemorrhage (SNAP) imaging, was extended by introducing 3D golden angle radial k-space sampling (GOAL-SNAP). Sliding window reconstruction was adopted to reconstruct images at different inversion delay times (different T1 contrasts) for voxelwise T1 fitting. Phantom studies were performed to test the accuracy of T1 mapping with GOAL-SNAP against a two-dimensional inversion recovery (IR) spin-echo (SE) sequence. In vivo studies were performed in six healthy volunteers (mean age, 27.8 years ± 3.0 [standard deviation]; age range, 24-32 years; five male) and five patients with atherosclerosis (mean age, 66.4 years ± 5.5; range, 60-73 years; five male) to compare T1 measurements between vessel wall sections (five per artery) with and without intraplaque hemorrhage (IPH). Statistical analyses included Pearson correlation coefficient, Bland-Altman analysis, and Wilcoxon rank-sum test with data permutation by subject. Results Phantom T1 measurements with GOAL-SNAP and IR SE sequences showed excellent correlation (R 2 = 0.99), with a mean bias of -25.8 msec ± 43.6 and a mean percentage error of 4.3% ± 2.5. Minimum T1 was significantly different between sections with IPH and those without it (mean, 371 msec ± 93 vs 944 msec ± 120; P = .01). Estimated T1 of normal vessel wall and muscle were 1195 msec ± 136 and 1117 msec ± 153, respectively. Conclusion High-spatial-resolution (0.8 mm isotropic) time-efficient (5 minutes) vessel wall T1 mapping is achieved by using the GOAL-SNAP sequence. This sequence may yield more quantitative reproducible biomarkers with which to characterize IPH and monitor its progression. © RSNA, 2017.

  18. The Application of Buckling Reinforced Bracing and Shear Wall in Retrofitting of Existing Concrete Building

    Directory of Open Access Journals (Sweden)

    Mahdi Izadi

    2015-06-01

    Full Text Available Vulnerable buildings and their rehabilitation are important problems for earthquake regions. In recent decades the goal of building rehabilitation and strengthening has gained different rehabilitation systems. However, most of these strengthening techniques disturb the occupants, who must vacate the building during renovation. Several retrofitting techniques such as addition masonry infill wall, application of buckling restrained braces and local modification of components has been studied in order to improve the overall seismic performance of such buildings. In response to many of the practical issues and economic considerations, engineers use often convergent unbuckling steel bracing frames as the lateral load resisting system during an earthquake.This kind of bracings increases the hardness and strength of concrete structures.The aim of the present study is the evaluation and comparison of seismic performance and retrofitting of an existing 7-storeys concrete structure with buckling restrained bracings and shear walls by nonlinear static procedure (NSP and accordance with cod-361. The results show that the buckling restrained bracing, decreased drift to acceptable levels and Structure behaves on the life safety of performance level.

  19. Vessel wall damage by X-rays and 15 MeV neutrons

    International Nuclear Information System (INIS)

    Aarnoudse, M.W.

    1979-01-01

    In two simple mucopolysaccharide systems, synovial fluid and subcutaneous connective tissue membranes, the degrading effects of 200 kVp X-rays and 15 MeV neutrons is compared. Due to the depolymerization of the mucopolysaccharides the viscosity of synovial fluid decreases and the permeability of the connective tissue membranes for saline increases after irradiation. In both systems a RBE of 0.6 has been found for fast neutrons. The atheromatous changes in the wall of elastic arteries (lipid penetration into the vessel wall and the formation of plaques consisting of large, lipid-filled foam cells) are studied in the carotid arteries of hypercholesterolemic rabbits, two months after irradiating the arteries with different doses of X-rays or neutrons. (Auth.)

  20. Estimation of the radial force on the tokamak vessel wall during fast transient events

    Energy Technology Data Exchange (ETDEWEB)

    Pustovitov, V. D., E-mail: pustovitov-vd@nrcki.ru [National Research Center Kurchatov Institute (Russian Federation)

    2016-11-15

    The radial force balance in a tokamak during fast transient events with a duration much shorter than the resistive time of the vacuum vessel wall is analyzed. The aim of the work is to analytically estimate the resulting integral radial force on the wall. In contrast to the preceding study [Plasma Phys. Rep. 41, 952 (2015)], where a similar problem was considered for thermal quench, simultaneous changes in the profiles and values of the pressure and plasma current are allowed here. Thereby, the current quench and various methods of disruption mitigation used in the existing tokamaks and considered for future applications are also covered. General formulas for the force at an arbitrary sequence or combination of events are derived, and estimates for the standard tokamak model are made. The earlier results and conclusions are confirmed, and it is shown that, in the disruption mitigation scenarios accepted for ITER, the radial forces can be as high as in uncontrolled disruptions.

  1. Research and tests of steel-concrete-steel sandwich composite shear wall in reactor containment of HTR-PM

    International Nuclear Information System (INIS)

    Sun Yunlun; Huang Wen; Zhang Ran; Zhang Pei; Tian Chunyu

    2014-01-01

    By quasi-static test of 8 specimens of steel-concrete-steel sandwich composite shear wall, the bearing capacity, hysteretic behavior, failure mode of the specimens was studied. So was the effect of the shear-span ratios, steel ratios and spacing of studs on the properties of the specimens. The failure patterns of all specimens with different shear-span ratios between 1.0 and 1.5 were compression-bending failure. The hysteretic curves of all specimens were relatively plump, which validated the well deformability and energy dissipation capacity of the specimens. When shear-span ratio less than 1.5, the shear property of the steel plate was well played, and so was the deformability of the specimens. The bigger the steel ratio was, the better the lateral resistance capacity and the deformability was. Among the spacing of studs in the test, the spacing of studs had no significant effect on the bearing capacity, deformability and ductility of the specimens. Based on the principle of superposition an advised formula for the compression-bending capacity of the shear wall was proposed, which fitted well with the test result and had a proper safety margin. (author)

  2. Evaluation of Nonlinear Behavior of Dual Steel Frame-Shear Wall System by a Group of Real Earthquakes

    Directory of Open Access Journals (Sweden)

    Reza Bemanian

    2016-03-01

    Full Text Available Dual system of steel moment frame and steel plate shear wall has many advantages in comparison to the other systems. Since the last four decades the dual system has been used more frequently in new and existing structures. the steel shear wall has many advantages such as high ductility, strength, stiffness and it has light weight, it consequent reduce lateral forces and time efficiency in contracture procedure. The aim of this study is to evaluate the seismic performance of the dual steel frame steel plate shear wall system in comparison with the moment resisting frame using nonlinear dynamic analysis. A dual System of Steel Moment frame and steel Plate shear walls system and a moment resisting frame is chosen a frame of four stories building were designed by used existing code. The height of each floor is 3.5 m. Seismic behavior of frame evaluate using nonlinear dynamic analysis. For this purpose a set of seven earthquake ground motions were appropriately selected and applied to the systems. Interstory drift ratio, input energy, distribution frames responses in height were compared for the systems under two different hazard level of ground motion and the results were analyzed.

  3. General and crevice corrosion study of the in-wall shielding materials for ITER vacuum vessel

    Science.gov (United States)

    Joshi, K. S.; Pathak, H. A.; Dayal, R. K.; Bafna, V. K.; Kimihiro, Ioki; Barabash, V.

    2012-11-01

    Vacuum vessel In-Wall Shield (IWS) will be inserted between the inner and outer shells of the ITER vacuum vessel. The behaviour of IWS in the vacuum vessel especially concerning the susceptibility to crevice of shielding block assemblies could cause rapid and extensive corrosion attacks. Even galvanic corrosion may be due to different metals in same electrolyte. IWS blocks are not accessible until life of the machine after closing of vacuum vessel. Hence, it is necessary to study the susceptibility of IWS materials to general corrosion and crevice corrosion under operations of ITER vacuum vessel. Corrosion properties of IWS materials were studied by using (i) Immersion technique and (ii) Electro-chemical Polarization techniques. All the sample materials were subjected to a series of examinations before and after immersion test, like Loss/Gain weight measurement, SEM analysis, and Optical stereo microscopy, measurement of surface profile and hardness of materials. After immersion test, SS 304B4 and SS 304B7 showed slight weight gain which indicate oxide layer formation on the surface of coupons. The SS 430 material showed negligible weight loss which indicates mild general corrosion effect. On visual observation with SEM and Metallography, all material showed pitting corrosion attack. All sample materials were subjected to series of measurements like Open Circuit potential, Cyclic polarization, Pitting potential, protection potential, Critical anodic current and SEM examination. All materials show pitting loop in OC2 operating condition. However, its absence in OC1 operating condition clearly indicates the activity of chloride ion to penetrate oxide layer on the sample surface, at higher temperature. The critical pitting temperature of all samples remains between 100° and 200°C.

  4. Vessel Wall Inflammation of Takayasu Arteritis Detected by Contrast-Enhanced Magnetic Resonance Imaging: Association with Disease Distribution and Activity.

    Directory of Open Access Journals (Sweden)

    Yoko Kato

    Full Text Available The assessment of the distribution and activity of vessel wall inflammation is clinically important in patients with Takayasu arteritis. Magnetic resonance imaging (MRI is a useful tool, but the clinical utility of late gadolinium enhancement (LGE in Takayasu arteritis has yet to be determined. The aim of the present study was to evaluate the utility of LGE in assessing vessel wall inflammation and disease activity in Takayasu arteritis.We enrolled 49 patients with Takayasu arteritis who had undergone 1.5 T MRI. Patients were divided into Active (n = 19 and Inactive disease (n = 30 groups. The distribution of vessel wall inflammation using angiography and LGE was assessed by qualitative analysis. In 79% and 63% of patients in Active and Inactive groups, respectively, greater distribution of vessel wall inflammation was observed with LGE than with conventional angiography. MRI values of pre- and post-contrast signal-to-noise ratios (SNR, SNR increment (post-SNR minus pre-SNR, pre- and post-contrast contrast-to-noise ratios (CNR, and CNR increment (post-CNR minus pre-CNR were evaluated at arterial wall sites with the highest signal intensity using quantitative analysis of post-contrast LGE images. No statistically significant differences in MRI parameters were observed between Active and Inactive groups. Contrast-enhanced MRI was unable to accurately detect active disease.Contrast-enhanced MRI has utility in detecting the distribution of vessel wall inflammation but has less utility in assessing disease activity in Takayasu arteritis.

  5. About a mechanism of the influence of shear stress for viscosity of the blood in vessels of small diameter

    Directory of Open Access Journals (Sweden)

    Лев Николаевич Катюхин

    2014-12-01

    Full Text Available It is proposed a physiological and experimentally confirmed explanation of Fåhraeus-Lindqvist-effect in capillaries using the profile analyses of osmotic deformability of red blood cells. It was shown the dose-dependent change of the erythrocytes deformability in the stage of isotropic spheres after forming artificial water pores (nystatin and occlusion (PbCl2 of available pores. The Sigma-effect reducing of hematocrit and viscosity in a shear flow of blood through the vessels of a small diameter was conditioned by the interchange of liquid phase between the erythrocyte and the plasma.

  6. Computational fluid dynamics comparisons of wall shear stress in patient-specific coronary artery bifurcation using coronary angiography and optical coherence tomography

    Science.gov (United States)

    Poon, Eric; Thondapu, Vikas; Chin, Cheng; Scheerlinck, Cedric; Zahtila, Tony; Mamon, Chris; Nguyen, Wilson; Ooi, Andrew; Barlis, Peter

    2016-11-01

    Blood flow dynamics directly influence biology of the arterial wall, and are closely linked with the development of coronary artery disease. Computational fluid dynamics (CFD) solvers may be employed to analyze the hemodynamic environment in patient-specific reconstructions of coronary arteries. Although coronary X-ray angiography (CA) is the most common medical imaging modality for 3D arterial reconstruction, models reconstructed from CA assume a circular or elliptical cross-sectional area. This limitation can be overcome with a reconstruction technique fusing CA with intravascular optical coherence tomography (OCT). OCT scans the interior of an artery using near-infrared light, achieving a 10-micron resolution and providing unprecedented detail of vessel geometry. We compared 3D coronary artery bifurcation models generated using CA alone versus OCT-angiography fusion. The model reconstructed from CA alone is unable to identify the detailed geometrical variations of diseased arteries, and also under-estimates the cross-sectional vessel area compared to OCT-angiography fusion. CFD was performed in both models under pulsatile flow in order to identify and compare regions of low wall shear stress, a hemodynamic parameter directly linked with progression of atherosclerosis. Supported by ARC LP150100233 and VLSCI VR0210.

  7. Repair and Strengthening by Use of Superficial Fixed Laminates of Cracked Masonry Walls Sheared Horizontally-Laboratory Tests

    International Nuclear Information System (INIS)

    Kubica, Jan; Kwiecien, Arkadiusz; Zajac, Boguslaw

    2008-01-01

    There are many methods of crack repairing in masonry structures. One of them is repair and strengthening by using of superficial fixed laminates, especially in case of masonry walls with plastering on their both sides. The initial laboratory tests of three different types of strengthening of diagonal cracked masonry wallettes are presented. Tests concerned three clay brick masonry walls subjected to horizontal shearing with two levels of precompression and strengthened by flexible polymer injection, superficial glass fixed by polymer fibre laminate plates and using of CRFP strips stiff fixed to the wall surface by polymer and stiff resin epoxy fixing are presented and discussed

  8. Three-dimensional imaging of the aortic vessel wall using an elastin-specific magnetic resonance contrast agent.

    Science.gov (United States)

    Makowski, Marcus R; Preissel, Anne; von Bary, Christian; Warley, Alice; Schachoff, Sylvia; Keithan, Alexandra; Cesati, Richard R; Onthank, David C; Schwaiger, Markus; Robinson, Simon P; Botnar, René M

    2012-07-01

    The aim of this study was to demonstrate the feasibility of high-resolution 3-dimensional aortic vessel wall imaging using a novel elastin-specific magnetic resonance contrast agent (ESMA) in a large animal model. The thoracic aortic vessel wall of 6 Landrace pigs was imaged using a novel ESMA and a nonspecific control agent. On day 1, imaging was performed before and after the administration of a nonspecific control agent, gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA; Bayer Schering AG, Berlin, Germany). On day 3, identical scans were repeated before and after the administration of a novel ESMA (Lantheus Medical Imaging, North Billerica, Massachusetts). Three-dimensional inversion recovery gradient echo delayed-enhancement imaging and magnetic resonance (MR) angiography of the thoracic aortic vessel wall were performed on a 1.5-T MR scanner (Achieva; Philips Medical Systems, the Netherlands). The signal-to-noise ratio and the contrast-to-noise ratio of arterial wall enhancement, including the time course of enhancement, were assessed for ESMA and Gd-DTPA. After the completion of imaging sessions, histology, electron microscopy, and inductively coupled plasma mass spectroscopy were performed to localize and quantify the gadolinium bound to the arterial vessel wall. Administration of ESMA resulted in a strong enhancement of the aortic vessel wall on delayed-enhancement imaging, whereas no significant enhancement could be measured with Gd-DTPA. Ninety to 100 minutes after the administration of ESMA, significantly higher signal-to-noise ratio and contrast-to-noise ratio could be measured compared with the administration of Gd-DTPA (45.7 ± 9.6 vs 13.2 ± 3.5, P wall imaging using a novel ESMA in a large animal model under conditions resembling a clinical setting. Such an approach could be useful for the fast 3-dimensional assessment of the arterial vessel wall in the context of atherosclerosis, aortic aneurysms, and hypertension.

  9. Saccharomyces cerevisiae gene expression changes during rotating wall vessel suspension culture

    Science.gov (United States)

    Johanson, Kelly; Allen, Patricia L.; Lewis, Fawn; Cubano, Luis A.; Hyman, Linda E.; Hammond, Timothy G.

    2002-01-01

    This study utilizes Saccharomyces cerevisiae to study genetic responses to suspension culture. The suspension culture system used in this study is the high-aspect-ratio vessel, one type of the rotating wall vessel, that provides a high rate of gas exchange necessary for rapidly dividing cells. Cells were grown in the high-aspect-ratio vessel, and DNA microarray and metabolic analyses were used to determine the resulting changes in yeast gene expression. A significant number of genes were found to be up- or downregulated by at least twofold as a result of rotational growth. By using Gibbs promoter alignment, clusters of genes were examined for promoter elements mediating these genetic changes. Candidate binding motifs similar to the Rap1p binding site and the stress-responsive element were identified in the promoter regions of differentially regulated genes. This study shows that, as in higher order organisms, S. cerevisiae changes gene expression in response to rotational culture and also provides clues for investigations into the signaling pathways involved in gravitational response.

  10. A multi-component parallel-plate flow chamber system for studying the effect of exercise-induced wall shear stress on endothelial cells.

    Science.gov (United States)

    Wang, Yan-Xia; Xiang, Cheng; Liu, Bo; Zhu, Yong; Luan, Yong; Liu, Shu-Tian; Qin, Kai-Rong

    2016-12-28

    In vivo studies have demonstrated that reasonable exercise training can improve endothelial function. To confirm the key role of wall shear stress induced by exercise on endothelial cells, and to understand how wall shear stress affects the structure and the function of endothelial cells, it is crucial to design and fabricate an in vitro multi-component parallel-plate flow chamber system which can closely replicate exercise-induced wall shear stress waveforms in artery. The in vivo wall shear stress waveforms from the common carotid artery of a healthy volunteer in resting and immediately after 30 min acute aerobic cycling exercise were first calculated by measuring the inner diameter and the center-line blood flow velocity with a color Doppler ultrasound. According to the above in vivo wall shear stress waveforms, we designed and fabricated a parallel-plate flow chamber system with appropriate components based on a lumped parameter hemodynamics model. To validate the feasibility of this system, human umbilical vein endothelial cells (HUVECs) line were cultured within the parallel-plate flow chamber under abovementioned two types of wall shear stress waveforms and the intracellular actin microfilaments and nitric oxide (NO) production level were evaluated using fluorescence microscope. Our results show that the trends of resting and exercise-induced wall shear stress waveforms, especially the maximal, minimal and mean wall shear stress as well as oscillatory shear index, generated by the parallel-plate flow chamber system are similar to those acquired from the common carotid artery. In addition, the cellular experiments demonstrate that the actin microfilaments and the production of NO within cells exposed to the two different wall shear stress waveforms exhibit different dynamic behaviors; there are larger numbers of actin microfilaments and higher level NO in cells exposed in exercise-induced wall shear stress condition than resting wall shear stress condition

  11. Investigation of residual stresses in thick-walled vessels with combination of autofrettage and wire-winding

    International Nuclear Information System (INIS)

    Sedighi, M.; Jabbari, A.H.

    2013-01-01

    Wire-winding and autofrettage processes can be used to introduce beneficial residual stress in the cylinder of thick-walled pressure vessels. In both techniques, internal residual compressive stress will increase internal pressure capacity, improve fatigue life and reduce fatigue crack initiation. The purpose of this paper is to analyze the effects of wire-winding on an autofrettaged thick-walled vessel. Direct method which is a modified Variable Material Properties (VMP) method has been used in order to calculate residual stresses in an autofrettaged vessel. Since wire-winding is done after autofrettage process, the tangent and/or Young's modulus could be changed. For this reason, a new wire-winding method based on Direct Method is introduced. The obtained results for wire-wound autofrettaged vessels are validated by finite element method. The results show that by using this approach, the residual hoop stresses in a wire-wound autofrettaged vessel have a more desirable distribution in the cylinder. -- Highlights: • Combination of autofrettage and wire-winding in pressure vessels has been presented. • A new method based on Direct method is presented for wire-winding process. • Residual hoop stresses are compared in vessels cylinders for different cases. • The residual hoop stress has a more desirable stress distribution. • The benefits of the combined vessel are highlighted in comparison with single cases

  12. Seismic and Power Generation Performance of U-Shaped Steel Connected PV-Shear Wall under Lateral Cyclic Loading

    Directory of Open Access Journals (Sweden)

    Hongmei Zhang

    2014-01-01

    Full Text Available BIPV is now widely used in office and residential buildings, but its seismic performance still remained vague especially when the photovoltaic (PV modules are installed on high-rise building facades. A new form of reinforced concrete shear wall integrated with photovoltaic module is proposed in this paper, aiming to apply PV module to the facades of high-rise buildings. In this new form, the PV module is integrated with the reinforced concrete wall by U-shaped steel connectors through embedded steel plates. The lateral cyclic loading test is executed to investigate the seismic behavior and the electric and thermal performance with different drift angles. The seismic behavior, including failure pattern, lateral force-top displacement relationship, and deformation capacity, was investigated. The power generation and temperature variation on the back of the PV module and both sides of the shear wall were also tested. Two main results are demonstrated through the experiment: (1 the U-shaped steel connectors provide enough deformation capacity for the compatibility of the PV module to the shear wall during the whole cyclic test; (2 the electricity generation capacity is effective and stable during this seismic simulation test.

  13. Time-Resolved Particle Image Velocimetry Measurements with Wall Shear Stress and Uncertainty Quantification for the FDA Nozzle Model.

    Science.gov (United States)

    Raben, Jaime S; Hariharan, Prasanna; Robinson, Ronald; Malinauskas, Richard; Vlachos, Pavlos P

    2016-03-01

    We present advanced particle image velocimetry (PIV) processing, post-processing, and uncertainty estimation techniques to support the validation of computational fluid dynamics analyses of medical devices. This work is an extension of a previous FDA-sponsored multi-laboratory study, which used a medical device mimicking geometry referred to as the FDA benchmark nozzle model. Experimental measurements were performed using time-resolved PIV at five overlapping regions of the model for Reynolds numbers in the nozzle throat of 500, 2000, 5000, and 8000. Images included a twofold increase in spatial resolution in comparison to the previous study. Data was processed using ensemble correlation, dynamic range enhancement, and phase correlations to increase signal-to-noise ratios and measurement accuracy, and to resolve flow regions with large velocity ranges and gradients, which is typical of many blood-contacting medical devices. Parameters relevant to device safety, including shear stress at the wall and in bulk flow, were computed using radial basis functions. In addition, in-field spatially resolved pressure distributions, Reynolds stresses, and energy dissipation rates were computed from PIV measurements. Velocity measurement uncertainty was estimated directly from the PIV correlation plane, and uncertainty analysis for wall shear stress at each measurement location was performed using a Monte Carlo model. Local velocity uncertainty varied greatly and depended largely on local conditions such as particle seeding, velocity gradients, and particle displacements. Uncertainty in low velocity regions in the sudden expansion section of the nozzle was greatly reduced by over an order of magnitude when dynamic range enhancement was applied. Wall shear stress uncertainty was dominated by uncertainty contributions from velocity estimations, which were shown to account for 90-99% of the total uncertainty. This study provides advancements in the PIV processing methodologies over

  14. Experimental and numerical investigations of higher mode effects on seismic inelastic response of reinforced concrete shear walls

    Science.gov (United States)

    Ghorbanirenani, Iman

    This thesis presents two experimental programs together with companion numerical studies that were carried out on reinforced concrete shear walls: static tests and dynamic (shake table) tests. The first series of experiments were monotonic and cyclic quasi-static testing on ductile reinforced concrete shear wall specimens designed and detailed according to the seismic provisions of NBCC 2005 and CSA-A23.3-04 standard. The tests were carried out on full-scale and 1:2.37 reduced scale wall specimens to evaluate the seismic design provisions and similitude law and determine the appropriate scaling factor that could be applied for further studies such as dynamic tests. The second series of experiments were shake table tests conducted on two identical 1:2.33 scaled, 8-storey moderately ductile reinforced concrete shear wall specimens to investigate the effects of higher modes on the inelastic response of slender walls under high frequency ground motions expected in Eastern North America. The walls were designed and detailed according to the seismic provisions of NBCC 2005 and CSA-A23.3-04 standard. The objectives were to validate and understand the inelastic response and interaction of shear, flexure and axial loads in plastic hinge zones of the walls considering the higher mode effects and to investigate the formation of second hinge in upper part of the wall due to higher mode responses. Second mode response significantly affected the response of the walls. This caused inelastic flexural response to develop at the 6th level with approximately the same rotation ductility compared to that observed at the base. Dynamic amplification of the base shear forces was also observed in both walls. Numerical modeling of these two shake table tests was performed to evaluate the test results and validate current modeling approaches. Nonlinear time history analyses were carried out by the reinforced concrete fibre element (OpenSees program) and finite element (VecTor2 program

  15. Stress analysis in pressure vessels by mixed finite element methods taking into account shear deformation

    International Nuclear Information System (INIS)

    Franca, L.P.; Toledo, E.M.; Loula, A.F.D.; Garcia, E.L.M.

    1988-12-01

    A new finite element method is employed to approximate axisymmetric shell problems. This formulation enhances stability and accuracy, from thin to moderately thick shells, compared to the correspondent Galerkin finite element approximations. Numerical results illustrate the good performance of the present method on some typical pressure vessels aplications. (author) [pt

  16. Stress in closed thin-walled tubes of single box subjected by shear forces and application to airfoils

    Directory of Open Access Journals (Sweden)

    Zebbiche Toufik

    2014-09-01

    Full Text Available The presented work is to develop a numerical computation program to determine the distribution of the shear stress to shear in closed tubes with asymmetric single thin wall section with a constant thickness and applications to airfoils and therefore determining the position and value of the maximum stress. In the literature, there are exact analytical solutions only for some sections of simple geometries such as circular section. Hence our interest is focused on the search of approximate numerical solutions for more complex sections used in aeronautics. In the second stage the position of the shear center is determined so that the section does not undergo torsion. The analytic function of the boundary of the airfoil is obtained by using the cubic spline interpolation since it is given in the form of tabulated points.

  17. "Sausage-string" appearance of arteries and arterioles can be caused by an instability of the blood vessel wall

    DEFF Research Database (Denmark)

    Jacobsen, Jens Christian Brings; Beierholm, Ulrik; Mikkelsen, Rene

    2002-01-01

    Vascular damage induced by acute hypertension is preceded by a peculiar pattern where blood vessels show alternating regions of constrictions and dilations ("sausages on a string"). The pattern occurs in the smaller blood vessels, and it plays a central role in causing the vascular damage. A rela...... phenomenon. Experimental data suggest that the structural changes induced by the instability may cause secondary damage to the wall of small arteries and arterioles in the form of endothelial hyperpermeability followed by local fibrinoid necrosis of the vascular wall.......Vascular damage induced by acute hypertension is preceded by a peculiar pattern where blood vessels show alternating regions of constrictions and dilations ("sausages on a string"). The pattern occurs in the smaller blood vessels, and it plays a central role in causing the vascular damage....... A related vascular pattern has been observed in larger vessels from several organs during angiography. In the larger vessels the occurrence of the pattern does not appear to be related to acute hypertension. A unifying feature between the phenomenon in large and small vessels seems to be an increase...

  18. Effects of iodinated contrast media on common carotid and brachial artery blood flow and wall shear stress

    International Nuclear Information System (INIS)

    Irace, C.; Tamburini, S.; Bertucci, B.; Franceschi, M.S. de; Gnasso, A.

    2006-01-01

    The aim of our study was to evaluate the effect of the intravenous contrast media iomeprol on wall shear stress, blood flow and vascular parameters in the common carotid and brachial artery. Thirty outpatients undergoing thoracic or abdominal spiral CT scans were studied. The internal diameter and flow velocity of the common carotid and brachial artery were evaluated by ultrasound, and blood viscosity was measured before and after low osmolality iomeprol (Iomeron 350) injection. The wall shear stress, blood flow and pulsatility index were calculated. To test the differences between groups, the Wilcoxon rank test and Mann Whitney U test were applied. Blood viscosity decreased slightly, but significantly after contrast media (4.6±0.7 vs. 4.5±0.7 mPa.s, P=0.02). Contrarily, blood flow and wall shear stress did not change in the common carotid artery, but significantly decreased in the brachial artery (0.9±0.4 vs. 0.6±0.3 ml/s, P<0.0001, and 41.5±13.9 vs. 35.3±11.0 dynes/cm2, P<0.002, respectively), whereas the pulsatility index significantly increased in the brachial artery (5.0±3.3 vs. 7.5±5.3, P<0.001). Iomeprol injection causes blood flow and wall shear stress reduction of the brachial artery; the rise in the pulsatility index suggests an increase in peripheral vascular resistance. Further investigation is needed to evaluate whether these modifications can be clinically relevant. (orig.)

  19. An investigation on vulnerability assessment of steel structures with thin steel shear wall through development of fragility curves

    OpenAIRE

    Mohsen Gerami; Saeed Ghaffari; Amir Mahdi Heidari Tafreshi

    2017-01-01

    Fragility curves play an important role in damage assessment of buildings. Probability of damage induction to the structure against seismic events can be investigated upon generation of afore mentioned curves. In current research 360 time history analyses have been carried out on structures of 3, 10 and 20 story height and subsequently fragility curves have been adopted. The curves are developed based on two indices of inter story drifts and equivalent strip axial strains of the shear wall. T...

  20. Rationalization and utilization of double-wall vacuum vessel for tokamak fusion facility

    International Nuclear Information System (INIS)

    Nakahira, Masataka

    2005-09-01

    Vacuum Vessel (VV) of ITER is difficult to apply a non-destructive in-service inspection (ISI) and then new safety concept is needed. Present fabrication standards are not applicable to the VV, because the access is limited to the backside of closure weld of double wall. Fabrication tolerance of VV is ± 5mm even the structure is huge as high as 10m. This accuracy requires a rational method on the estimation of welding deformation. In this report, an inherent safety feature of the tokamak is proved closing up a special characteristic of termination of fusion reaction due to tiny water leak. A rational concept not to require ISI without sacrificing safety is shown based on this result. A partial penetration T-welded joint is proposed to establish a rational fabrication method of double wall. Strength and susceptibility to crevice corrosion is evaluated for this joint and feasibility is confirmed. A rational method of estimation of welding deformation for large and complex structure is proposed and the efficiency is shown by comparing analysis and experimental results of full-scale test. (author)

  1. Shear flow over a plane wall with an axisymmetric cavity or a circular orifice of finite thickness

    International Nuclear Information System (INIS)

    Pozrikidis, C.

    1994-01-01

    Shear flow over a plane wall that contains an axisymmetric depression or pore is studied using a new boundary integral method which is suitable for computing three-dimensional Stokes flow within axisymmetric domains. Numerical results are presented for cavities in the shape of a section of a sphere or a circular cylinder of finite length, and for a family of pores or orifices with finite thickness. The results illustrate the distribution of shear stresses over the plane wall and inside the cavities or pores. It is found that in most cases, the distribution of shear stresses over the plane wall, around the depressions, is well approximated with that for flow over an orifice of infinitesimal thickness for which an exact solution is available. The kinematic structure of the flow is discussed with reference to eddy formation and three-dimensional flow reversal. It is shown that the thickness of a circular orifice or depth of a pore play an important role in determining the kinematical structure of the flow underneath the orifice in the lower half-space

  2. Development of a wall-shear-stress sensor and measurements in mini-channels with partial blockages

    Science.gov (United States)

    Afara, Samer; Medvescek, James; Mydlarski, Laurent; Baliga, Bantwal R.; MacDonald, Mark

    2014-05-01

    The design, construction, operation and validation of a wall-shear-stress sensor, and measurements obtained using this sensor in air flows downstream of partial blockages in a mini-channel are presented. The sensor consisted of a hot wire mounted over a small rectangular slot and operated using a constant-temperature anemometer. It was used to investigate flows similar to those within the mini-channels inside notebook computers. The overall goal of the present work was to develop a sensor suitable for measurements of the wall-shear stress in such flows, which can be used to validate corresponding numerical simulations, as the latter are known to be often surprisingly inaccurate. To this end, measurements of the wall-shear stress, and the corresponding statistical moments and power spectral densities, were obtained at different distances downstream of the partial blockage, with blockage ratios of 39.7, 59.2, and 76.3 %. The Reynolds number (based on average velocity and hydraulic diameter) ranged from 100 to 900. The results confirmed the presence of unsteadiness, separation, reattachment, and laminar-turbulent transition in the ostensibly laminar flow of air in mini-channels with partial blockages. The present results demonstrate why accurate numerical predictions of cooling air flows in laptop and notebook computers remain a challenging task.

  3. Bicuspid aortic valves are associated with increased wall and turbulence shear stress levels compared to trileaflet aortic valves.

    Science.gov (United States)

    Saikrishnan, Neelakantan; Mirabella, Lucia; Yoganathan, Ajit P

    2015-06-01

    Congenital bicuspid aortic valves (BAVs) are associated with accelerated disease progression, such as leaflet calcification and ascending aorta dilatation. Although common underlying genetic factors have been implicated in accelerated disease in BAV patients, several studies have suggested that altered hemodynamics also play a role in this disease process. The present study compares turbulence and wall shear stress (WSS) measurements between various BAV and trileaflet aortic valve (TAV) models to provide information for mechanobiological models of BAV disease. BAV and TAV models were constructed from excised porcine aortic valves to simulate parametric variations in BAV stenosis, hemodynamics and geometry. Particle image velocimetry experiments were conducted at physiological pressure conditions to characterize velocity fields in the ascending aorta. The velocity fields were post-processed to calculate turbulence, viscous and wall shear stresses in the ascending aorta. Stenosed BAV models showed the presence of eccentric systolic jets, causing increased WSS. Lower cardiac output resulted in a narrower jet, lower turbulence and lower viscous shear stress (VSS). The specific severe stenosis BAV model studied here showed reduced WSS due to reduction in non-fused leaflet mobility. Dilation of the aorta did not affect any turbulence or VSS, but reduced the WSS. In comparison with BAVs, TAVs have similar VSS values, but much smaller WSS and turbulence levels. These increased turbulence  and WSS levels in BAVs may play a key role in amplifying the biological responses of the ascending aorta wall and valvular leaflets, and support the hemodynamic underpinnings of BAV disease processes.

  4. Analysis of wall shear stress around a competitive swimmer using 3D Navier-Stokes equations in CFD.

    Science.gov (United States)

    Popa, C V; Zaidi, H; Arfaoui, A; Polidori, G; Taiar, R; Fohanno, S

    2011-01-01

    This paper deals with the flow dynamics around a competitive swimmer during underwater glide phases occurring at the start and at every turn. The influence of the head position, namely lifted up, aligned and lowered, on the wall shear stress and the static pressure distributions is analyzed. The problem is considered as 3D and in steady hydrodynamic state. Three velocities (1.4 m/s, 2.2 m/s and 3.1 m/s) that correspond to inter-regional, national and international swimming levels are studied. The flow around the swimmer is assumed turbulent. The Reynolds-averaged Navier-Stokes (RANS) equations are solved with the standard k-ω turbulent model by using the CFD (computational fluid dynamics) numerical method based on a volume control approach. Numerical simulations are carried out with the ANSYS FLUENT® CFD code. The results show that the wall shear stress increases with the velocity and consequently the drag force opposing the movement of the swimmer increases as well. Also, high wall shear stresses are observed in the areas where the body shape, globally rigid in form, presents complex surface geometries such as the head, shoulders, buttocks, heel and chest.

  5. Augmentative effect of pulsatility on the wall shear stress in tube flow.

    Science.gov (United States)

    Nakata, M; Tatsumi, E; Tsukiya, T; Taenaka, Y; Nishimura, T; Nishinaka, T; Takano, H; Masuzawa, T; Ohba, K

    1999-08-01

    Wall shear stress (WSS) has been considered to play an important role in the physiological and metabolic functions of the vascular endothelial cells. We investigated the effects of the pulse rate and the maximum flow rate on the WSS to clarify the influence of pulsatility. Water was perfused in a 1/2 inch transparent straight cylinder with a nonpulsatile centrifugal pump and a pulsatile pneumatic ventricular assist device (VAD). In nonpulsatile flow (NF), the flow rate was changed 1 to 6 L/min by 1 L/min increments to obtain standard values of WSS at each flow rate. In pulsatile flow (PF), the pulse rate was controlled at 40, 60, and 80 bpm, and the maximum flow rate was varied from 3.3 to 12.0 L/min while the mean flow rate was kept at 3 L/min. The WSS was estimated from the velocity profile at measuring points using the laser illuminated fluorescence method. In NF, the WSS was 12.0 dyne/cm2 at 3 L/min and 33.0 dyne/cm2 at 6 L/min. In PF, the pulse rate change with the same mean, and the maximum flow rate did not affect WSS. On the other hand, the increase in the maximum flow rate at the constant mean flow rate of 3 L/min augmented the mean WSS from 13.1 to 32.9 dyne/cm2. We concluded that the maximum flow rate exerted a substantial augmentative effect on WSS, and the maximum flow rate was a dominant factor of pulsatility in this effect.

  6. A numerical model for adiabatic shear bands with application to a thick-walled cylinder in 304 stainless steel

    International Nuclear Information System (INIS)

    Liu, Mingtao; Li, Yongchi; Hu, Xiuzhang; Hu, Haibo

    2014-01-01

    The formation of an adiabatic shear band (ASB) experiences three stages: stable plastic flow, nucleation and a fluid-like stage. For different stages, the microstructures of the material undergo great changes. The mechanical behavior of the material in each stage has its own unique characteristics. To describe these characteristics, a multi-stage model for the shear band is proposed. For the stable plastic flow stage, a modified adiabatic J–C constitutive relationship is used. For the nucleation stage, the effects of work hardening and temperature softening are described by a power function of plastic strain. A Newtonian fluid model is used for the fluid-like stage. The formation of a shear band is an instability process. Various defects in the material are perturbation sources, which change the local yield stress. To describe the disturbances, a probability factor is introduced into the macroscopic constitutive relationship. The yield stress in the material is assumed to obey a Gaussian distribution. The multi-stage model combined with a probability factor is applied to simulate the rupture of thick-walled cylinder in 304 Stainless Steel (304SS). A close agreement is found between the simulation and experimental results, such as the failure mechanism, shear band spacing and propagating velocity of the shear band. By combining the experimental results with the simulation results, the importance of the nucleation stage is emphasized. (paper)

  7. Flow and wall shear stress characterization after endovascular aneurysm repair and endovascular aneurysm sealing in an infrarenal aneurysm model.

    Science.gov (United States)

    Boersen, Johannes T; Groot Jebbink, Erik; Versluis, Michel; Slump, Cornelis H; Ku, David N; de Vries, Jean-Paul P M; Reijnen, Michel M P J

    2017-12-01

    Endovascular aneurysm repair (EVAR) with a modular endograft has become the preferred treatment for abdominal aortic aneurysms. A novel concept is endovascular aneurysm sealing (EVAS), consisting of dual endoframes surrounded by polymer-filled endobags. This dual-lumen configuration is different from a bifurcation with a tapered trajectory of the flow lumen into the two limbs and may induce unfavorable flow conditions. These include low and oscillatory wall shear stress (WSS), linked to atherosclerosis, and high shear rates that may result in thrombosis. An in vitro study was performed to assess the impact of EVAR and EVAS on flow patterns and WSS. Four abdominal aortic aneurysm phantoms were constructed, including three stented models, to study the influence of the flow divider on flow (Endurant [Medtronic, Minneapolis, Minn], AFX [Endologix, Irvine, Calif], and Nellix [Endologix]). Experimental models were tested under physiologic resting conditions, and flow was visualized with laser particle imaging velocimetry, quantified by shear rate, WSS, and oscillatory shear index (OSI) in the suprarenal aorta, renal artery (RA), and common iliac artery. WSS and OSI were comparable for all models in the suprarenal aorta. The RA flow profile in the EVAR models was comparable to the control, but a region of lower WSS was observed on the caudal wall compared with the control. The EVAS model showed a stronger jet flow with a higher shear rate in some regions compared with the other models. Small regions of low WSS and high OSI were found near the distal end of all stents in the common iliac artery compared with the control. Maximum shear rates in each region of interest were well below the pathologic threshold for acute thrombosis. The different stent designs do not influence suprarenal flow. Lower WSS is observed in the caudal wall of the RA after EVAR and a higher shear rate after EVAS. All stented models have a small region of low WSS and high OSI near the distal outflow

  8. Distinct defects in collagen microarchitecture underlie vessel-wall failure in advanced abdominal aneurysms and aneurysms in Marfan syndrome

    NARCIS (Netherlands)

    Lindeman, J.H.N.; Ashcroft, B.A.; Beenakker, J.-W.M.; Es, M. van; Koekkoek, N.B.R.; Prins, F.A.; Tielemans, J.F.; Abdul-Hussien, H.; Bank, R.A.; Oosterkamp, T.H.

    2010-01-01

    An aneurysm of the aorta is a common pathology characterized by segmentalweakeningof the artery.Althoughit isgenerally accepted that the vessel-wall weakening is caused by an impaired collagen metabolism, a clear association has been demonstrated only for rare syndromes such as the vascular type

  9. Study of the Arrangement Effect of Units on the Shear Strength Masonry Walls in Meso-Scale

    Directory of Open Access Journals (Sweden)

    M. Sepehrinia

    2016-12-01

    Full Text Available Masonry is one of the oldest building materials which have been used in most heritage structures and new construction. In this study by using a meso-scale finite element model, the behavior of masonry walls is investigated under monotonic loading by Abaqus software. The most important factor in determining the behavior of masonry structures is discontinuity joints which are interface between unit and mortar. In most previous studies cohesive element is used for modeling of interface element. But in this study, by ignoring cohesive elements that represents the interface element between unit and mortar in masonry structures, it can be seen that while reducing the computational requirements, the results are in good agreement with experimental studies. Another important factor in the behavior of masonry walls is the arrangement of masonry units. In this study the overlapping effect of rows of units on the shear strength and failure mode of masonry walls have been investigated. As a result, it was observed that by increasing overlap, shear resistance of masonry walls increased.

  10. The Sheer Stress of Shear Stress: Responses of the Vascular Wall to a Haemodynamic Force

    NARCIS (Netherlands)

    C. Cheng (Caroline (Ka Lai))

    2006-01-01

    textabstractStudies in the hemodynamic field point to a strong relation between shear stress and the onset to vascular diseases such as atherosclerosis. Data from in vitro studies using sheared endothelial cells have provided insight into the possible mechanisms involved. However, the lack of an

  11. Automated registration of multispectral MR vessel wall images of the carotid artery

    Energy Technology Data Exchange (ETDEWEB)

    Klooster, R. van ' t; Staring, M.; Reiber, J. H. C.; Lelieveldt, B. P. F.; Geest, R. J. van der, E-mail: rvdgeest@lumc.nl [Department of Radiology, Division of Image Processing, Leiden University Medical Center, 2300 RC Leiden (Netherlands); Klein, S. [Department of Radiology and Department of Medical Informatics, Biomedical Imaging Group Rotterdam, Erasmus MC, Rotterdam 3015 GE (Netherlands); Kwee, R. M.; Kooi, M. E. [Department of Radiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht 6202 AZ (Netherlands)

    2013-12-15

    Purpose: Atherosclerosis is the primary cause of heart disease and stroke. The detailed assessment of atherosclerosis of the carotid artery requires high resolution imaging of the vessel wall using multiple MR sequences with different contrast weightings. These images allow manual or automated classification of plaque components inside the vessel wall. Automated classification requires all sequences to be in alignment, which is hampered by patient motion. In clinical practice, correction of this motion is performed manually. Previous studies applied automated image registration to correct for motion using only nondeformable transformation models and did not perform a detailed quantitative validation. The purpose of this study is to develop an automated accurate 3D registration method, and to extensively validate this method on a large set of patient data. In addition, the authors quantified patient motion during scanning to investigate the need for correction. Methods: MR imaging studies (1.5T, dedicated carotid surface coil, Philips) from 55 TIA/stroke patients with ipsilateral <70% carotid artery stenosis were randomly selected from a larger cohort. Five MR pulse sequences were acquired around the carotid bifurcation, each containing nine transverse slices: T1-weighted turbo field echo, time of flight, T2-weighted turbo spin-echo, and pre- and postcontrast T1-weighted turbo spin-echo images (T1W TSE). The images were manually segmented by delineating the lumen contour in each vessel wall sequence and were manually aligned by applying throughplane and inplane translations to the images. To find the optimal automatic image registration method, different masks, choice of the fixed image, different types of the mutual information image similarity metric, and transformation models including 3D deformable transformation models, were evaluated. Evaluation of the automatic registration results was performed by comparing the lumen segmentations of the fixed image and

  12. Automated registration of multispectral MR vessel wall images of the carotid artery

    International Nuclear Information System (INIS)

    Klooster, R. van 't; Staring, M.; Reiber, J. H. C.; Lelieveldt, B. P. F.; Geest, R. J. van der; Klein, S.; Kwee, R. M.; Kooi, M. E.

    2013-01-01

    Purpose: Atherosclerosis is the primary cause of heart disease and stroke. The detailed assessment of atherosclerosis of the carotid artery requires high resolution imaging of the vessel wall using multiple MR sequences with different contrast weightings. These images allow manual or automated classification of plaque components inside the vessel wall. Automated classification requires all sequences to be in alignment, which is hampered by patient motion. In clinical practice, correction of this motion is performed manually. Previous studies applied automated image registration to correct for motion using only nondeformable transformation models and did not perform a detailed quantitative validation. The purpose of this study is to develop an automated accurate 3D registration method, and to extensively validate this method on a large set of patient data. In addition, the authors quantified patient motion during scanning to investigate the need for correction. Methods: MR imaging studies (1.5T, dedicated carotid surface coil, Philips) from 55 TIA/stroke patients with ipsilateral <70% carotid artery stenosis were randomly selected from a larger cohort. Five MR pulse sequences were acquired around the carotid bifurcation, each containing nine transverse slices: T1-weighted turbo field echo, time of flight, T2-weighted turbo spin-echo, and pre- and postcontrast T1-weighted turbo spin-echo images (T1W TSE). The images were manually segmented by delineating the lumen contour in each vessel wall sequence and were manually aligned by applying throughplane and inplane translations to the images. To find the optimal automatic image registration method, different masks, choice of the fixed image, different types of the mutual information image similarity metric, and transformation models including 3D deformable transformation models, were evaluated. Evaluation of the automatic registration results was performed by comparing the lumen segmentations of the fixed image and

  13. Numerical modeling of the pulse wave propagation in large blood vessels based on liquid and wall interaction

    International Nuclear Information System (INIS)

    Rup, K; Dróżdż, A

    2014-01-01

    The purpose of this article is to develop a non-linear, one-dimensional model of pulse wave propagation in the arterial cardiovascular system. The model includes partial differential equations resulting from the balance of mass and momentum for the fluid-filled area and the balance equation for the area of the wall and vessels. The considered mathematical model of pulse wave propagation in the thoracic aorta section takes into account the viscous dissipation of fluid energy, realistic values of parameters describing the physicochemical properties of blood and vessel wall. Boundary and initial conditions contain the appropriate information obtained from in vivo measurements. As a result of the numerical solution of the mass and momentum balance equations for the blood and the equilibrium equation for the arterial wall area, time- dependent deformation, respective velocity profiles and blood pressure were determined.

  14. Effect of a new specimen size on fatigue crack growth behavior in thick-walled pressure vessels

    International Nuclear Information System (INIS)

    Shariati, Mahmoud; Mohammadi, Ehsan; Masoudi Nejad, Reza

    2017-01-01

    Fatigue crack growth in thick-walled pressure vessels is an important factor affecting their fracture. Predicting the path of fatigue crack growth in a pressure vessel is the main issue discussed in fracture mechanics. The objective of this paper is to design a new geometrical specimen in fatigue to define the behavior of semi-elliptical crack growth in thick-walled pressure vessels. In the present work, the importance of the behavior of fatigue crack in test specimen and real conditions in thick-walled pressure vessels is investigated. The results of fatigue loading on the new specimen are compared with the results of fatigue loading in a cylindrical pressure vessel and a standard specimen. Numerical and experimental methods are used to investigate the behavior of fatigue crack growth in the new specimen. For this purpose, a three-dimensional boundary element method is used for fatigue crack growth under stress field. The modified Paris model is used to estimate fatigue crack growth rates. In order to verify the numerical results, fatigue test is carried out on a couple of specimens with a new geometry made of ck45. A comparison between experimental and numerical results has shown good agreement. - Highlights: • This paper provides a new specimen to define the behavior of fatigue crack growth. • We estimate the behavior of fatigue crack growth in specimen and pressure vessel. • A 3D finite element model has been applied to estimate the fatigue life. • We compare the results of fatigue loading for cylindrical vessel and specimens. • Comparison between experimental and numerical results has shown a good agreement.

  15. The effect of a self-balancing through wall residual stress distribution on the extension of a through-wall crack in a pressure vessel

    International Nuclear Information System (INIS)

    Smith, E.

    1993-01-01

    Leak-before-break arguments for pressurized components involve a comparison of the critical size of crack that will grow unstably under accident loadings and the critical leakage crack size for normal operation loadings. The paper is concerned with the former crack size and particularly with regard to the effect of residual stresses on the critical unstable crack size. Results from an analysis of a simple simulation model are used to provide underpinning for the view, expressed by Green and Knowles at the 1992 American Society of Mechanical Engineers Pressure Vessel and Piping Conference, that self-balancing through-wall residual stresses have little overall effect on the extension of a through-wall crack in a pressure vessel

  16. Assessment of the impact of degraded shear wall stiffnesses on seismic plant risk and seismic design loads

    International Nuclear Information System (INIS)

    Klamerus, E.W.; Bohn, M.P.; Johnson, J.J.; Asfura, A.P.; Doyle, D.J.

    1994-02-01

    Test results sponsored by the USNRC have shown that reinforced shear wall (Seismic Category I) structures exhibit stiffnesses and natural frequencies which are smaller than those calculated in the design process. The USNRC has sponsored Sandia National Labs to perform an evaluation of the effects of the reduced frequencies on several existing seismic PRAs in order to determine the seismic risk implications inherent in these test results. This report presents the results for the re-evaluation of the seismic risk for three nuclear power plants: the Peach Bottom Atomic Power Station, the Zion Nuclear Power Plant, and Arkansas Nuclear One -- Unit 1 (ANO-1). Increases in core damage frequencies for seismic initiated events at Peach Bottom were 25 to 30 percent (depending on whether LLNL or EPRI hazard curves were used). At the ANO-1 site, the corresponding increases in plant risk were 10 percent (for each set of hazard curves). Finally, at Zion, there was essentially no change in the computed core damage frequency when the reduction in shear wall stiffness was included. In addition, an evaluation of deterministic ''design-like'' structural dynamic calculations with and without the shear stiffness reductions was made. Deterministic loads calculated for these two cases typically increased on the order of 10 to 20 percent for the affected structures

  17. Investigation into a major crack that occurred during fabrication of a thick walled alloy pressure vessel

    International Nuclear Information System (INIS)

    Griffiths, Roger R.

    2002-01-01

    A high pressure thick walled (171 mm+cladding) reactor was under construction when a crack, with a total length of about 2.5 m, occurred at a nozzle. An investigation was conducted to determine how manufacture could safely proceed. This revealed that the primary cause of cracking was the method by which preheat had been applied to the vessel for the welding operation, coupled with the very low impact values achieved by the weld metal in the as-welded condition. Investigation also centred on the use of dehydrogenation heat treatment (DHT) instead of an intermediate stress relief (ISR), and the oxidised nature of the fracture surface. The oxidation could not be satisfactorily explained, and as a result neither the time the fracture occurred nor the significance of applying DHT in place of ISR could be absolutely determined. Nevertheless it was concluded that fracture probably occurred before DHT was applied. It was recommended that the method of preheat be revised and ISR applied without cooling below minimum preheat temperature. Further review of the incident resulted in additional recommendations for prevention of a recurrence in future work. One critical aspect was the lack of response to the poor as-welded toughness properties of the weld deposit

  18. Investigation into a major crack that occurred during fabrication of a thick walled alloy pressure vessel

    Energy Technology Data Exchange (ETDEWEB)

    Griffiths, Roger R

    2002-08-01

    A high pressure thick walled (171 mm+cladding) reactor was under construction when a crack, with a total length of about 2.5 m, occurred at a nozzle. An investigation was conducted to determine how manufacture could safely proceed. This revealed that the primary cause of cracking was the method by which preheat had been applied to the vessel for the welding operation, coupled with the very low impact values achieved by the weld metal in the as-welded condition. Investigation also centred on the use of dehydrogenation heat treatment (DHT) instead of an intermediate stress relief (ISR), and the oxidised nature of the fracture surface. The oxidation could not be satisfactorily explained, and as a result neither the time the fracture occurred nor the significance of applying DHT in place of ISR could be absolutely determined. Nevertheless it was concluded that fracture probably occurred before DHT was applied. It was recommended that the method of preheat be revised and ISR applied without cooling below minimum preheat temperature. Further review of the incident resulted in additional recommendations for prevention of a recurrence in future work. One critical aspect was the lack of response to the poor as-welded toughness properties of the weld deposit.

  19. Fracture mechanics of thin wall cylindrical pressure vessels: an interim review

    International Nuclear Information System (INIS)

    Kurtz, R.J.; Olson, N.J.

    1977-08-01

    The report is a result of activities in the LMFBR Fuel Rod Transient Performance Program sponsored by the LMFBR Branch of the Division of Project Management, U.S. Nuclear Regulatory Commission. One of the objectives is to develop predictions relative to the length, direction, and rate of growth of cladding rips subsequent to (or concurrent with) the initial cladding breach during unprotected transients. To provide a basis for evaluation, Battelle, Pacific Northwest Laboratories has reviewed most available fracture mechanics assessments relative to thin-wall cylindrical pressure vessels. The purpose of the report is to review the various fracture mechanics models and to describe the pertinent fracture parameters. It is intended to provide a formal basis for assessing future analytical predictions of fracture behavior of materials exposed to transient LMFBR thermal and mechanical loading conditions. In addition, the report is expected to provide reference material for evaluating or developing experimental programs required to properly address the problem of predicting fracture behavior of materials during transient events

  20. Critical Heat Flux Experiments on the Reactor Vessel Wall Using 2-D Slice Test Section

    International Nuclear Information System (INIS)

    Jeong, Yong Hoon; Chang, Soon Heung; Baek, Won-Pil

    2005-01-01

    The critical heat flux (CHF) on the reactor vessel outer wall was measured using the two-dimensional slice test section. The radius and the channel area of the test section were 2.5 m and 10 cm x 15 cm, respectively. The flow channel area and the heater width were smaller than those of the ULPU experiments, but the radius was greater than that of the ULPU. The CHF data under the inlet subcooling of 2 to 25 deg. C and the mass flux 0 to 300 kg/m 2 .s had been acquired. The measured CHF value was generally slightly lower than that of the ULPU. The difference possibly comes from the difference of the test section material and the thickness. However, the general trend of CHF according to the mass flux was similar with that of the ULPU. The experimental CHF data were compared with the predicted values by SULTAN correlation. The SULTAN correlation predicted well this study's data only for the mass flux higher than 200 kg/m 2 .s, and for the exit quality lower than 0.05. The local condition-based correlation was developed, and it showed good prediction capability for broad quality (-0.01 to 0.5) and mass flux ( 2 .s) conditions with a root-mean-square error of 2.4%. There were increases in the CHF with trisodium phosphate-added water

  1. Manufacturing and maintenance technologies developed for a thick-wall structure of the ITER vacuum vessel

    International Nuclear Information System (INIS)

    Onozuka, M.; Alfile, J.P.; Aubert, Ph.; Dagenais, J.-F.; Grebennikov, D.; Ioki, K.; Jones, L.; Koizumi, K.; Krylov, V.; Maslakowski, J.; Nakahira, M.; Nelson, B.; Punshon, C.; Roy, O.; Schreck, G.

    2001-01-01

    Development of welding, cutting and non-destructive testing (NDT) techniques, and development of remotized systems have been carried out for on-site manufacturing and maintenance of the thick-wall structure of the International Thermonuclear Experimental Reactor (ITER) vacuum vessel (VV). Conventional techniques, including tungsten inert gas welding, plasma cutting, and ultrasonic inspection, have been improved and optimized for the application to thick austenitic stainless steel plates. In addition, advanced methods have been investigated, including reduced-pressure electron-beam and multi-pass neodymium-doped yttrium aluminum garnet (NdYAG) laser welding, NdYAG laser cutting, and electro-magnetic acoustic transducer inspection, to improve cost and technical performance. Two types of remotized systems with different payloads have been investigated and one of them has been fabricated and demonstrated in field joint welding, cutting, and NDT tests on test mockups and full-scale ITER VV sector models. The progress and results of this development to date provide a high level of confidence that the manufacturing and maintenance of the ITER VV is feasible

  2. Manufacturing and maintenance technologies developed for a thick-wall structure of the ITER vacuum vessel

    Energy Technology Data Exchange (ETDEWEB)

    Onozuka, M. E-mail: onozukm@itereu.de; Alfile, J.P.; Aubert, Ph.; Dagenais, J.-F.; Grebennikov, D.; Ioki, K.; Jones, L.; Koizumi, K.; Krylov, V.; Maslakowski, J.; Nakahira, M.; Nelson, B.; Punshon, C.; Roy, O.; Schreck, G

    2001-09-01

    Development of welding, cutting and non-destructive testing (NDT) techniques, and development of remotized systems have been carried out for on-site manufacturing and maintenance of the thick-wall structure of the International Thermonuclear Experimental Reactor (ITER) vacuum vessel (VV). Conventional techniques, including tungsten inert gas welding, plasma cutting, and ultrasonic inspection, have been improved and optimized for the application to thick austenitic stainless steel plates. In addition, advanced methods have been investigated, including reduced-pressure electron-beam and multi-pass neodymium-doped yttrium aluminum garnet (NdYAG) laser welding, NdYAG laser cutting, and electro-magnetic acoustic transducer inspection, to improve cost and technical performance. Two types of remotized systems with different payloads have been investigated and one of them has been fabricated and demonstrated in field joint welding, cutting, and NDT tests on test mockups and full-scale ITER VV sector models. The progress and results of this development to date provide a high level of confidence that the manufacturing and maintenance of the ITER VV is feasible.

  3. Preliminary electromagnetic, thermal and mechanical design for first wall and vacuum vessel of FAST

    Energy Technology Data Exchange (ETDEWEB)

    Lucca, F., E-mail: Flavio.Lucca@LTCalcoli.it [LT Calcoli srl, Piazza Prinetti 26/B, 23807 Merate, LC (Italy); Bertolini, C. [LT Calcoli srl, Piazza Prinetti 26/B, 23807 Merate, LC (Italy); Crescenzi, F.; Crisanti, F. [C.R. ENEA Frascati – UT FUS, Via E. Fermi 45, IT-00044 Frascati, RM (Italy); Di Gironimo, G. [CREATE, Università di Napoli Federico II, P.le Tecchio 80, 80125 Napoli (Italy); Labate, C. [CREATE, Università di Napoli Parthenope, Via Acton 38, 80133 Napoli (Italy); Manzoni, M.; Marconi, M.; Pagani, I. [LT Calcoli srl, Piazza Prinetti 26/B, 23807 Merate, LC (Italy); Ramogida, G. [C.R. ENEA Frascati – UT FUS, Via E. Fermi 45, IT-00044 Frascati, RM (Italy); Renno, F. [CREATE, Università di Napoli Federico II, P.le Tecchio 80, 80125 Napoli (Italy); Roccella, M. [LT Calcoli srl, Piazza Prinetti 26/B, 23807 Merate, LC (Italy); Roccella, S. [C.R. ENEA Frascati – UT FUS, Via E. Fermi 45, IT-00044 Frascati, RM (Italy); Viganò, F. [LT Calcoli srl, Piazza Prinetti 26/B, 23807 Merate, LC (Italy)

    2015-10-15

    The fusion advanced study torus (FAST), with its compact design, high toroidal field and plasma current, faces many of the problems met by ITER, and at the same time anticipates much of the DEMO relevant physics and technology. The conceptual design of the first wall (FW) and the vacuum vessel (VV) has been defined on the basis of FAST operative conditions and of “Snow Flakes” (SF) magnetic topology, which is also relevant for DEMO. The EM loads are one of the most critical load components for the FW and the VV during plasma disruptions and a first dimensioning of these components for such loads is mandatory. During this first phase of R&D activities the conceptual design of the FW and VV have been assessed estimating, by means of FE simulations, the EM loads due to a typical vertical disruption event (VDE) in FAST. EM loads were then transferred on a FE mechanical model of the FAST structures and the mechanical response of the FW and VV design for the analyzed VDE event was assessed. The results indicate that design criteria are not fully satisfied by the current drawing of the VV and FW components. The most critical regions have been individuated and the effect of some geometrical and material changes has been checked in order to improve the structure.

  4. Fracture toughness of epoxy/multi-walled carbon nanotube nano-composites under bending and shear loading conditions

    International Nuclear Information System (INIS)

    Ayatollahi, M.R.; Shadlou, S.; Shokrieh, M.M.

    2011-01-01

    Research highlights: → Mode I and mode II fracture tests were conducted on epoxy/MWCNT nano-composites. → Addition of MWCNT to epoxy increased both K Ic and K IIc of nano-composites. → The improvement in K IIc was more pronounced than in K Ic . → Mode I and mode II fracture surfaces were studied by scanning electron microscopy. -- Abstract: The effects of multi-walled carbon nanotubes (MWCNTs) on the mechanical properties of epoxy/MWCNT nano-composites were studied with emphasis on fracture toughness under bending and shear loading conditions. Several finite element (FE) analyses were performed to determine appropriate shear loading boundary conditions for a single-edge notch bend specimen (SENB) and an equation was derived for calculating the shear loading fracture toughness from the fracture load. It was seen that the increase in fracture toughness of nano-composite depends on the type of loading. That is to say, the presence of MWCNTs had a greater effect on fracture toughness of nano-composites under shear loading compared with normal loading. To study the fracture mechanisms, several scanning electron microscopy (SEM) pictures were taken from the fracture surfaces. A correlation was found between the characteristics of fracture surface and the mechanical behaviors observed in the fracture tests.

  5. Semiautomatic vessel wall detection and quantification of wall thickness in computed tomography images of human abdominal aortic aneurysms

    International Nuclear Information System (INIS)

    Shum, Judy; DiMartino, Elena S.; Goldhammer, Adam; Goldman, Daniel H.; Acker, Leah C.; Patel, Gopal; Ng, Julie H.; Martufi, Giampaolo; Finol, Ender A.

    2010-01-01

    Purpose: Quantitative measurements of wall thickness in human abdominal aortic aneurysms (AAAs) may lead to more accurate methods for the evaluation of their biomechanical environment. Methods: The authors describe an algorithm for estimating wall thickness in AAAs based on intensity histograms and neural networks involving segmentation of contrast enhanced abdominal computed tomography images. The algorithm was applied to ten ruptured and ten unruptured AAA image data sets. Two vascular surgeons manually segmented the lumen, inner wall, and outer wall of each data set and a reference standard was defined as the average of their segmentations. Reproducibility was determined by comparing the reference standard to lumen contours generated automatically by the algorithm and a commercially available software package. Repeatability was assessed by comparing the lumen, outer wall, and inner wall contours, as well as wall thickness, made by the two surgeons using the algorithm. Results: There was high correspondence between automatic and manual measurements for the lumen area (r=0.978 and r=0.996 for ruptured and unruptured aneurysms, respectively) and between vascular surgeons (r=0.987 and r=0.992 for ruptured and unruptured aneurysms, respectively). The authors' automatic algorithm showed better results when compared to the reference with an average lumen error of 3.69%, which is less than half the error between the commercially available application Simpleware and the reference (7.53%). Wall thickness measurements also showed good agreement between vascular surgeons with average coefficients of variation of 10.59% (ruptured aneurysms) and 13.02% (unruptured aneurysms). Ruptured aneurysms exhibit significantly thicker walls (1.78±0.39 mm) than unruptured ones (1.48±0.22 mm), p=0.044. Conclusions: While further refinement is needed to fully automate the outer wall segmentation algorithm, these preliminary results demonstrate the method's adequate reproducibility and

  6. Seismic Performance and Modeling of Reinforced Concrete and Post-Tensioned Precast Concrete Shear Walls

    OpenAIRE

    Tanyeri, Ahmet Can

    2014-01-01

    Past earthquakes have shown examples of unsatisfactory performance of buildings using reinforced concrete structural walls as the primary lateral-force-resisting system. In the 1994 Northridge earthquake, examples can be found where walls possessed too much overstrength, leading to unintended failure of collectors and floor systems, including precast and post-tensioned construction. In the 2010 Maule Chile earthquake, many structural wall buildings sustained severe damage. Although Chilean de...

  7. A More Realistic Lateral Load Pattern for Design of Reinforced Concrete Buildings with Moment Frames and Shear Walls

    International Nuclear Information System (INIS)

    Hosseini, Mahmood; Khosahmadi, Arash

    2008-01-01

    In this research it has been tried to find a more realistic distribution pattern for the seismic load in reinforced concrete (R/C) buildings, having moment frames with shear walls as their lateral resisting system, by using Nonlinear Time History Analyses (NLTHA). Having shear wall as lateral load bearing system decreases the effect of infill walls in the seismic behavior of the building, and therefore the case of buildings with shear walls has been considered for this study as the first stage of the studies on lateral load patterns for R/C buildings. For this purpose, by assuming three different numbers of bays in each direction and also three different numbers of stories for the buildings, several R/C buildings, have been studied. At first, the buildings have been designed by the Iranian National Code for R/C Buildings. Then they have been analyzed by a NLTHA software using the accelerograms of some well-known earthquakes. The used accelerograms have been also scaled to various levels of peak ground acceleration (PGA) such as 0.35 g, 0.50 g, and 0.70 g, to find out the effect of PGA in the seismic response. Numerical results have shown that firstly the values of natural period of the building and their shear force values, calculated by the code, are not appropriate in all cases. Secondly, it has been found out that the real lateral load pattern is quite different with the one suggested by the seismic code. Based on the NLTHA results a new lateral load pattern has been suggested for this kind of buildings, in the form of some story-dependent modification factors applied to the existing code formula. The effects of building's natural period, as well as its number of stories, are taken into account explicitly in the proposed new load pattern. The proposed load pattern has been employed to redesign the buildings and again by NLTHA the real lateral load distribution in each case has been obtained which has shown very good agreement with the proposed pattern

  8. Semianalytical analysis of shear walls with the use of discrete-continual finite element method. Part 1: Mathematical foundations

    Directory of Open Access Journals (Sweden)

    Akimov Pavel

    2016-01-01

    Full Text Available The distinctive paper is devoted to the two-dimensional semi-analytical solution of boundary problems of analysis of shear walls with the use of discrete-continual finite element method (DCFEM. This approach allows obtaining the exact analytical solution in one direction (so-called “basic” direction, also decrease the size of the problem to one-dimensional common finite element analysis. The resulting multipoint boundary problem for the first-order system of ordinary differential equations with piecewise constant coefficients is solved analytically. The proposed method is rather efficient for evaluation of the boundary effect (such as the stress field near the concentrated force. DCFEM also has a completely computer-oriented algorithm, computational stability, optimal conditionality of resultant system and it is applicable for the various loads at an arbitrary point or a region of the wall.

  9. Nonparenchymal cells cultivated from explants of fibrotic liver resemble endothelial and smooth muscle cells from blood vessel walls

    International Nuclear Information System (INIS)

    Voss, B.; Rauterberg, J.; Pott, G.; Brehmer, U.; Allam, S.; Lehmann, R.; von Bassewitz, D.B.

    1982-01-01

    Tissue specimens from human fibrotic liver obtained by needle biopsy were cultured. Two cell types emerged from the tissue explants. From their morphology and biosynthetic products they resembled smooth muscle cells and endothelial cells from blood vessel walls. In the endothelial cells, factor VIII-associated protein was demonstrated by indirect immunofluorescence. Synthesis of collagen types I and III, basement membrane collagen types IV and V, and fibronectin by both cell types was observed by immunofluorescence microscopy. Homogeneous cultures of smooth muscle cells were observed in subcultures. After incubation with [ 14 C]glycine, collagen was isolated and characterized by CM cellulose chromatography, and consisted mainly of types I and III. These data suggest involvement of mesenchymal cells in hepatic fibrosis; they presumably originate from blood vessel or sinusoidal walls

  10. The contribution of CASIEL infill walls to the shear resistance of steel frames

    NARCIS (Netherlands)

    Ng'Andu, B.M.; Martens, D.R.W; Vermeltfoort, A.T.

    2006-01-01

    In Europe, calcium silicate element (CASIEL) walls are increasingly employed as partitions and external claddings in buildings. The CASIEL infills and the frames mutually interact through frame-wall interfaces. This interaction has a significant influence on the load transmission paths of building

  11. Lymphocyte trafficking and HIV infection of human lymphoid tissue in a rotating wall vessel bioreactor

    Science.gov (United States)

    Margolis, L. B.; Fitzgerald, W.; Glushakova, S.; Hatfill, S.; Amichay, N.; Baibakov, B.; Zimmerberg, J.

    1997-01-01

    The pathogenesis of HIV infection involves a complex interplay between both the infected and noninfected cells of human lymphoid tissue, the release of free viral particles, the de novo infection of cells, and the recirculatory trafficking of peripheral blood lymphocytes. To develop an in vitro model for studying these various aspects of HIV pathogenesis we have utilized blocks of surgically excised human tonsils and a rotating wall vessel (RWV) cell culture system. Here we show that (1) fragments of the surgically excised human lymphoid tissue remain viable and retain their gross cytoarchitecture for at least 3 weeks when cultured in the RWV system; (2) such lymphoid tissue gradually shows a loss of both T and B cells to the surrounding growth medium; however, this cellular migration is reversible as demonstrated by repopulation of the tissue by labeled cells from the growth medium; (3) this cellular migration may be partially or completely inhibited by embedding the blocks of lymphoid tissue in either a collagen or agarose gel matrix; these embedded tissue blocks retain most of the basic elements of a normal lymphoid cytoarchitecture; and (4) both embedded and nonembedded RWV-cultured blocks of human lymphoid tissue are capable of productive infection by HIV-1 of at least three various strains of different tropism and phenotype, as shown by an increase in both p24 antigen levels and free virus in the culture medium, and by the demonstration of HIV-1 RNA-positive cells inside the tissue identified by in situ hybridization. It is therefore reasonable to suggest that gel-embedded and nonembedded blocks of human lymphoid tissue, cocultured with a suspension of tonsillar lymphocytes in an RWV culture system, constitute a useful model for simulating normal lymphocyte recirculatory traffic and provide a new tool for testing the various aspects of HIV pathogenesis.

  12. Vascular smooth muscle cells in cultures on lactide based polymers for potential construction of artificial vessel wall

    Czech Academy of Sciences Publication Activity Database

    Filová, Elena; Bačáková, Lucie; Lisá, Věra; Machová, Luďka; Lapčíková, Monika; Kubies, Dana; Proks, Vladimír; Rypáček, František

    2003-01-01

    Roč. 6, - (2003), s. 9-11 ISSN 1429-7248. [Konferencja Naukowa "Biomaterialy w medycynie i weterynarii" /13./. Rytro, 09.10.2003-12.10.2003] R&D Projects: GA AV ČR IAA4050202; GA MŠk LN00A065 Institutional research plan: CEZ:AV0Z4050913; CEZ:AV0Z5011922 Keywords : tissue engineering * bioactive polymers, RGD * bioartificial vessel wall Subject RIV: EI - Biotechnology ; Bionics

  13. Bobbin-Tool Friction-Stir Welding of Thick-Walled Aluminum Alloy Pressure Vessels

    Energy Technology Data Exchange (ETDEWEB)

    Dalder, E C; Pastrnak, J W; Engel, J; Forrest, R S; Kokko, E; Ternan, K M; Waldron, D

    2007-06-06

    It was desired to assemble thick-walled Al alloy 2219 pressure vessels by bobbin-tool friction-stir welding. To develop the welding-process, mechanical-property, and fitness-for-service information to support this effort, extensive friction-stir welding-parameter studies were conducted on 2.5 cm. and 3.8 cm. thick 2219 Al alloy plate. Starting conditions of the plate were the fully-heat-treated (-T62) and in the annealed (-O) conditions. The former condition was chosen with the intent of using the welds in either the 'as welded' condition or after a simple low-temperature aging treatment. Since preliminary stress-analyses showed that stresses in and near the welds would probably exceed the yield-strength of both 'as welded' and welded and aged weld-joints, a post-weld solution-treatment, quenching, and aging treatment was also examined. Once a suitable set of welding and post-weld heat-treatment parameters was established, the project divided into two parts. The first part concentrated on developing the necessary process information to be able to make defect-free friction-stir welds in 3.8 cm. thick Al alloy 2219 in the form of circumferential welds that would join two hemispherical forgings with a 102 cm. inside diameter. This necessitated going to a bobbin-tool welding-technique to simplify the tooling needed to react the large forces generated in friction-stir welding. The bobbin-tool technique was demonstrated on both flat-plates and plates that were bent to the curvature of the actual vessel. An additional issue was termination of the weld, i.e. closing out the hole left at the end of the weld by withdrawal of the friction-stir welding tool. This was accomplished by friction-plug welding a slightly-oversized Al alloy 2219 plug into the termination-hole, followed by machining the plug flush with both the inside and outside surfaces of the vessel. The second part of the project involved demonstrating that the welds were fit for the intended

  14. Method for the radiographic examination of the walls or components of an essentially closed vessel, and also the provision of means for the application of the method

    International Nuclear Information System (INIS)

    1978-01-01

    Method for the radiographic examination of the wall ports or supporting components of an essentially closed vessel, whereby one brings to the side of the vessel walls or supports under examination a radiation source and, to the opposite side, a radiation sensitive film, the film being irradiated by the source and thereafter developed, characterised in that one introduces into the inside of the vessel a hollow tube at a unique distance from the wall or support component, at least one end of the hollow tube being fed out and in which the hollow tube, during the period of the examination, the irradiation source or an irradiation sensitive film is introduced. (G.C.)

  15. Learning-based automated segmentation of the carotid artery vessel wall in dual-sequence MRI using subdivision surface fitting.

    Science.gov (United States)

    Gao, Shan; van 't Klooster, Ronald; Kitslaar, Pieter H; Coolen, Bram F; van den Berg, Alexandra M; Smits, Loek P; Shahzad, Rahil; Shamonin, Denis P; de Koning, Patrick J H; Nederveen, Aart J; van der Geest, Rob J

    2017-10-01

    The quantification of vessel wall morphology and plaque burden requires vessel segmentation, which is generally performed by manual delineations. The purpose of our work is to develop and evaluate a new 3D model-based approach for carotid artery wall segmentation from dual-sequence MRI. The proposed method segments the lumen and outer wall surfaces including the bifurcation region by fitting a subdivision surface constructed hierarchical-tree model to the image data. In particular, a hybrid segmentation which combines deformable model fitting with boundary classification was applied to extract the lumen surface. The 3D model ensures the correct shape and topology of the carotid artery, while the boundary classification uses combined image information of 3D TOF-MRA and 3D BB-MRI to promote accurate delineation of the lumen boundaries. The proposed algorithm was validated on 25 subjects (48 arteries) including both healthy volunteers and atherosclerotic patients with 30% to 70% carotid stenosis. For both lumen and outer wall border detection, our result shows good agreement between manually and automatically determined contours, with contour-to-contour distance less than 1 pixel as well as Dice overlap greater than 0.87 at all different carotid artery sections. The presented 3D segmentation technique has demonstrated the capability of providing vessel wall delineation for 3D carotid MRI data with high accuracy and limited user interaction. This brings benefits to large-scale patient studies for assessing the effect of pharmacological treatment of atherosclerosis by reducing image analysis time and bias between human observers. © 2017 American Association of Physicists in Medicine.

  16. Composite Behavior of a Novel Insulated Concrete Sandwich Wall Panel Reinforced with GFRP Shear Grids: Effects of Insulation Types.

    Science.gov (United States)

    Kim, JunHee; You, Young-Chan

    2015-03-03

    A full-scale experimental program was used in this study to investigate the structural behavior of novel insulated concrete sandwich wall panels (SWPs) reinforced with grid-type glass-fiber-reinforced polymer (GFRP) shear connectors. Two kinds of insulation-expanded polystyrene (EPS) and extruded polystyrene (XPS) with 100 mm thickness were incased between the two concrete wythes to meet the increasing demand for the insulation performance of building envelope. One to four GFRP shear grids were used to examine the degree of composite action of the two concrete wythes. Ten specimens of SWPs were tested under displacement control subjected to four-point concentrated loads. The test results showed that the SWPs reinforced with GFRP grids as shear connectors developed a high degree of composite action resulting in high flexural strength. The specimens with EPS foam exhibited an enhanced load-displacement behavior compared with the specimens with XPS because of the relatively stronger bond between insulation and concrete. In addition, the ultimate strength of the test results was compared to the analytical prediction with the mechanical properties of only GRFP grids. The specimens with EPS insulation presented higher strength-based composite action than the ones with XPS insulation.

  17. Responses of a 58-story RC dual core shear wall and outrigger frame building inferred from two earthquakes

    Science.gov (United States)

    Çelebi, Mehmet

    2016-01-01

    Responses of a dual core shear-wall and outrigger-framed 58-story building recorded during the Mw6.0 Napa earthquake of 24 August 2014 and the Mw3.8 Berkeley earthquake of 20 October 2011 are used to identify its dynamic characteristics and behavior. Fundamental frequencies are 0.28 Hz (NS), 0.25 Hz (EW), and 0.43 Hz (torsional). Rigid body motions due to rocking are not significant. Average drift ratios are small. Outrigger frames do not affect average drift ratios or mode shapes. Local site effects do not affect the response; however, response associated with deeper structure may be substantial. A beating effect is observed from data of both earthquakes but beating periods are not consistent. Low critical damping ratios may have contributed to the beating effect. Torsion is relatively larger above outriggers as indicated by the time-histories of motions at the roof, possibly due to the discontinuity of the stiffer shear walls above level 47.

  18. Energy release and its containment within thin-walled, backed vessels

    International Nuclear Information System (INIS)

    Chambers, D.I.

    1983-01-01

    The problem adressed is the containment of a sudden release of energy of a magnitude up to 4 x 10 11 joules in a reusable vessel. The design process began by formulating dynamic models for both the input to such a vessel and the vessel itself and using these models to generate a general response. Modifications to the input and a more specific response are discussed. Computer codes used in calculations are described and listed

  19. Pulsatile blood flow, shear force, energy dissipation and Murray's Law

    Directory of Open Access Journals (Sweden)

    Bengtsson Hans-Uno

    2006-08-01

    Full Text Available Abstract Background Murray's Law states that, when a parent blood vessel branches into daughter vessels, the cube of the radius of the parent vessel is equal to the sum of the cubes of the radii of daughter blood vessels. Murray derived this law by defining a cost function that is the sum of the energy cost of the blood in a vessel and the energy cost of pumping blood through the vessel. The cost is minimized when vessel radii are consistent with Murray's Law. This law has also been derived from the hypothesis that the shear force of moving blood on the inner walls of vessels is constant throughout the vascular system. However, this derivation, like Murray's earlier derivation, is based on the assumption of constant blood flow. Methods To determine the implications of the constant shear force hypothesis and to extend Murray's energy cost minimization to the pulsatile arterial system, a model of pulsatile flow in an elastic tube is analyzed. A new and exact solution for flow velocity, blood flow rate and shear force is derived. Results For medium and small arteries with pulsatile flow, Murray's energy minimization leads to Murray's Law. Furthermore, the hypothesis that the maximum shear force during the cycle of pulsatile flow is constant throughout the arterial system implies that Murray's Law is approximately true. The approximation is good for all but the largest vessels (aorta and its major branches of the arterial system. Conclusion A cellular mechanism that senses shear force at the inner wall of a blood vessel and triggers remodeling that increases the circumference of the wall when a shear force threshold is exceeded would result in the observed scaling of vessel radii described by Murray's Law.

  20. A wall shear stress sensor using a pair of sidewall doped cantilevers

    Science.gov (United States)

    Nguyen, Thanh-Vinh; Kazama, Ryohei; Takahashi, Hidetoshi; Takahata, Tomoyuki; Matsumoto, Kiyoshi; Shimoyama, Isao

    2017-07-01

    In this paper, we report on a micro-electro mechanical system (MEMS)-based piezoresistive sensor for measuring shear stress induced by an airflow. The advantages of the proposed sensor include a simple sensing method and a high resonance frequency due to the small size of the sensing elements. Our sensor consists of a pair of 3 µm thick cantilevers with piezoresistors formed on the sidewall of their hinges to detect lateral deformation in the cantilevers induced by an airflow. Each cantilever has a 200 µm  ×  400 µm plate supported by two 150 µm long, 4 µm wide beams. The piezoresistors on the two cantilevers are designed to deform in opposite manners when a shear stress is applied and in the same manner when a pressure is applied. Therefore, the applied shear stress can be detected from the difference in the responses of the two cantilevers without becoming conflated with pressure. In this paper, the design, fabrication and evaluation of the proposed sensor are reported and compared to numerical simulation results. From the experimental results, the resolution of the sensor and its first resonance frequency are 1.3 Pa and 3.9 kHz, respectively. Moreover, we show that the effect of temperature on the readout of the sensor can be eliminated using a temperature-compensating piezoresistor fabricated on the same sensor chip. Finally, using the fabricated sensor, the measurement of the shear stress induced by an airflow with velocity between  -10 and 10 m s-1 is demonstrated.

  1. A wall shear stress sensor using a pair of sidewall doped cantilevers

    International Nuclear Information System (INIS)

    Nguyen, Thanh-Vinh; Shimoyama, Isao; Kazama, Ryohei; Takahashi, Hidetoshi; Takahata, Tomoyuki; Matsumoto, Kiyoshi

    2017-01-01

    In this paper, we report on a micro-electro mechanical system (MEMS)-based piezoresistive sensor for measuring shear stress induced by an airflow. The advantages of the proposed sensor include a simple sensing method and a high resonance frequency due to the small size of the sensing elements. Our sensor consists of a pair of 3 µ m thick cantilevers with piezoresistors formed on the sidewall of their hinges to detect lateral deformation in the cantilevers induced by an airflow. Each cantilever has a 200 µ m  ×  400 µ m plate supported by two 150 µ m long, 4 µ m wide beams. The piezoresistors on the two cantilevers are designed to deform in opposite manners when a shear stress is applied and in the same manner when a pressure is applied. Therefore, the applied shear stress can be detected from the difference in the responses of the two cantilevers without becoming conflated with pressure. In this paper, the design, fabrication and evaluation of the proposed sensor are reported and compared to numerical simulation results. From the experimental results, the resolution of the sensor and its first resonance frequency are 1.3 Pa and 3.9 kHz, respectively. Moreover, we show that the effect of temperature on the readout of the sensor can be eliminated using a temperature-compensating piezoresistor fabricated on the same sensor chip. Finally, using the fabricated sensor, the measurement of the shear stress induced by an airflow with velocity between  −10 and 10 m s −1 is demonstrated. (paper)

  2. HIV-1 and recombinant gp120 affect the survival and differentiation of human vessel wall-derived mesenchymal stem cells

    Directory of Open Access Journals (Sweden)

    Pasquinelli Gianandrea

    2011-05-01

    Full Text Available Abstract Background HIV infection elicits the onset of a progressive immunodeficiency and also damages several other organs and tissues such as the CNS, kidney, heart, blood vessels, adipose tissue and bone. In particular, HIV infection has been related to an increased incidence of cardiovascular diseases and derangement in the structure of blood vessels in the absence of classical risk factors. The recent characterization of multipotent mesenchymal cells in the vascular wall, involved in regulating cellular homeostasis, suggests that these cells may be considered a target of HIV pathogenesis. This paper investigated the interaction between HIV-1 and vascular wall resident human mesenchymal stem cells (MSCs. Results MSCs were challenged with classical R5 and X4 HIV-1 laboratory strains demonstrating that these strains are able to enter and integrate their retro-transcribed proviral DNA in the host cell genome. Subsequent experiments indicated that HIV-1 strains and recombinant gp120 elicited a reliable increase in apoptosis in sub-confluent MSCs. Since vascular wall MSCs are multipotent cells that may be differentiated towards several cell lineages, we challenged HIV-1 strains and gp120 on MSCs differentiated to adipogenesis and endotheliogenesis. Our experiments showed that the adipogenesis is increased especially by upregulated PPARγ activity whereas the endothelial differentiation induced by VEGF treatment was impaired with a downregulation of endothelial markers such as vWF, Flt-1 and KDR expression. These viral effects in MSC survival and adipogenic or endothelial differentiation were tackled by CD4 blockade suggesting an important role of CD4/gp120 interaction in this context. Conclusions The HIV-related derangement of MSC survival and differentiation may suggest a direct role of HIV infection and gp120 in impaired vessel homeostasis and in genesis of vessel damage observed in HIV-infected patients.

  3. Roughness Effects on Organized Motions in a Wall Shear Layer Flow

    Science.gov (United States)

    Haigermoser, Christian; Vesely, Lukas; Lapolla, Massimillano; Onorato, Michele

    2006-11-01

    Turbulent boundary layer measurements on a zero-pressure gradient flat plate with two different roughness, a 2D and a 3D roughness, were carried out. The main object of the study was to investigate the impact of the wall roughness on the turbulent flow structures. The momentum thickness Reynolds number for the smooth wall was Reθ˜ 1900. PIV measurements were taken in the streamwise wall-normal plane. The PIV images covered the whole logarithmic region and the major part of the outer layer. The instant flow images for the two roughness show features similar to the one expected in a smooth wall turbulent boundary layer, as described by Adrian et al. (JFM 2000). Statistical analysis was performed to enlighten quantitative differences between the different flow fields. For instance, two point streamwise velocity correlations show that the major effect of the roughness is to tilt the inclination of the hairpin vortex packets towards the wall normal direction; being the 3D roughness more effective in producing this displacement. Full results will be shown and discussed during the presentation.

  4. Contribution to the understanding of the behaviour of reinforced concrete shear walls under seismic loading: contribution of experiment and modeling to the design

    International Nuclear Information System (INIS)

    Ile, N.

    2000-12-01

    This thesis deals with aspects of seismic behaviour of reinforced concrete shear walls (RCSW). Its objective is to introduce a useful modelling approach for addressing the non-linear response of a large variety of RCSW and to identify several aspects in which this numerical approach could be implemented into design applications. Firstly, the characteristics of the behaviour of RCSW under seismic loading, some design principles and different modelling approaches are discussed. As an important lack of knowledge in several fields was identified, it was considered that three types of shear walls deserve more attention: slightly reinforced slender walls; U-shaped walls and heavily reinforced squat shear walls. A local modelling approach is adopted and the material constitutive models are described in details. Secondly, the behaviour of the two mock-up, CAMUS I and II, tested on the shaking-table during the CAMUS programme, which are slightly reinforced and designed according to the French code PS92 is simulated using a 2-D finite element model (FEM). For comparison purposes, the case of the CAMUS III mock-up, designed according to EC8, is considered. We are then dealing with the case of U-shaped walls under dynamic and cyclic loading. The results obtained from numerical simulations, based on a 3-D shell FEM, are compared with those obtained from tests carried out in the frame of the ICONS programme. Finally, the numerical model is applied to the case of heavily reinforced squat shear walls (similar to those used in the nuclear power plant buildings) subjected to shear loading. A 2-D FEM is considered in order to simulate the behaviour of three different walls, which were tested pseudo-dynamically during the SAFE programme. The results from both experimental and numerical studies are compared and discussed. The most important factors affecting the behaviour of RCSW are highlighted. Different examples of possible contributions to design are presented. (author)

  5. Near-Wall Turbulence Modelling of Rotating and Curved Shear Flows

    Energy Technology Data Exchange (ETDEWEB)

    Pettersson, Bjoern Anders

    1997-12-31

    This thesis deals with verification and refinement of turbulence models within the framework of the Reynolds-averaged approach. It pays special attention to modelling the near-wall region, where the turbulence is strongly non-homogeneous and anisotropic. It also studies in detail the effects associated with an imposed rotation of the reference frame or streamline curvature. The objective with near-wall turbulence closure modelling is to formulate a set of equations governing single point turbulence statistics, which can be solved in the region of the flow which extends to the wall. This is in contrast to the commonly adopted wall-function approach in which the wall-boundary conditions are replaced by matching conditions in the logarithmic region. The near-wall models allow more flexibility by not requiring any such universal behaviour. Assessment of the novel elliptic relaxation approach to model the proximity of a solid boundary reveals an encouraging potential used in conjunction with second-moment and eddy-viscosity closures. The most natural level of closure modelling to predict flows affected by streamline curvatures or an imposed rotation of the reference frame is at the second-moment closure (SMC) level. Although SMCs naturally accounts for the effects of system rotation, the usual application of a scalar dissipation rate equation is shown to require ad hoc corrections in some cases in order to give good results. The elliptic relaxation approach is also used in conjunction with non-linear pressure-strain models and very encouraging results are obtained for rotating flows. Rotational induced secondary motions are vital to predicting the effects of system rotation. Some severe weaknesses of non-linear pressure-strain models are also indicated. Finally, a modelling methodology for anisotropic dissipation in nearly homogeneous turbulence are proposed. 84 refs., 56 figs., 16 tabs.

  6. High-resolution MRI vessel wall imaging: spatial and temporal patterns of reversible cerebral vasoconstriction syndrome and central nervous system vasculitis.

    Science.gov (United States)

    Obusez, E C; Hui, F; Hajj-Ali, R A; Cerejo, R; Calabrese, L H; Hammad, T; Jones, S E

    2014-08-01

    High-resolution MR imaging is an emerging tool for evaluating intracranial artery disease. It has an advantage of defining vessel wall characteristics of intracranial vascular diseases. We investigated high-resolution MR imaging arterial wall characteristics of CNS vasculitis and reversible cerebral vasoconstriction syndrome to determine wall pattern changes during a follow-up period. We retrospectively reviewed 3T-high-resolution MR imaging vessel wall studies performed on 26 patients with a confirmed diagnosis of CNS vasculitis and reversible cerebral vasoconstriction syndrome during a follow-up period. Vessel wall imaging protocol included black-blood contrast-enhanced T1-weighted sequences with fat suppression and a saturation band, and time-of-flight MRA of the circle of Willis. Vessel wall characteristics including enhancement, wall thickening, and lumen narrowing were collected. Thirteen patients with CNS vasculitis and 13 patients with reversible cerebral vasoconstriction syndrome were included. In the CNS vasculitis group, 9 patients showed smooth, concentric wall enhancement and thickening; 3 patients had smooth, eccentric wall enhancement and thickening; and 1 patient was without wall enhancement and thickening. Six of 13 patients had follow-up imaging; 4 patients showed stable smooth, concentric enhancement and thickening; and 2 patients had resoluton of initial imaging findings. In the reversible cerebral vasoconstriction syndrome group, 10 patients showed diffuse, uniform wall thickening with negligible-to-mild enhancement. Nine patients had follow-up imaging, with 8 patients showing complete resolution of the initial findings. Postgadolinium 3T-high-resolution MR imaging appears to be a feasible tool in differentiating vessel wall patterns of CNS vasculitis and reversible cerebral vasoconstriction syndrome changes during a follow-up period. © 2014 by American Journal of Neuroradiology.

  7. The shear resistance of steel frames infilled with CASIEL wall panels

    NARCIS (Netherlands)

    Ng'Andu, B.M.; Vermeltfoort, A.T.

    2007-01-01

    In Europe, calcium silicate element (CASIEL) walls are increasingly employed as partitions and intemal claddings in buildings. When surrounded by frames, the interaction between the CASIEL infills and the frames has a significant influence on the load transmission paths of building structures. In

  8. Nonlinear response of vessel walls due to short-time thermomechanical loading

    International Nuclear Information System (INIS)

    Pfeiffer, P.A.; Kulak, R.F.

    1994-01-01

    Maintaining structural integrity of the reactor pressure vessel (RPV) during a postulated core melt accident is an important safety consideration in the design of the vessel. This study addresses the failure predictions of the vessel due to thermal and pressure loadings fro the molten core debris depositing on the lower head of the vessel. Different loading combinations were considered based on the dead load, yield stress assumptions, material response and internal pressurization. The analyses considered only short term failure (quasi static) modes, long term failure modes were not considered. Short term failure modes include plastic instabilities of the structure and failure due to exceeding the failure strain. Long term failure odes would be caused by creep rupture that leads to plastic instability of the structure. Due to the sort time durations analyzed, creep was not considered in the analyses presented

  9. Turbulent transport and shear at the E x B velocity in wall plasma of the TF-2 tokamak

    International Nuclear Information System (INIS)

    Budaev, V.P.

    1999-01-01

    Turbulence of near-the-wall plasma and potentialities of affecting the turbulence and periphery transport of the TF-2 tokamak by inducing radial electric fields and ergodization of periphery magnetic structure have been investigated, the results are presented. Essential role of the E x B velocity shear in suppression of the turbulence and turbulent transport in periphery has been pointed out. Decrease in transport losses stemming from effect of radial electric fields is brought about suppression of turbulence amplitude, decrease in correlations and decrease in the width of the wave numbers spectrum. Profiles of plasma density, electron temperature, turbulence level, electric fields over entire periphery of discharge change as a result. Ergodization of magnetic structure also results in the change of properties of periphery turbulence and turbulent transport [ru

  10. An investigation on vulnerability assessment of steel structures with thin steel shear wall through development of fragility curves

    Directory of Open Access Journals (Sweden)

    Mohsen Gerami

    2017-02-01

    Full Text Available Fragility curves play an important role in damage assessment of buildings. Probability of damage induction to the structure against seismic events can be investigated upon generation of afore mentioned curves. In current research 360 time history analyses have been carried out on structures of 3, 10 and 20 story height and subsequently fragility curves have been adopted. The curves are developed based on two indices of inter story drifts and equivalent strip axial strains of the shear wall. Time history analysis is carried out in Perform 3d considering 10 far field seismograms and 10 near fields. Analysis of low height structures revealed that they are more vulnerable in accelerations lower than 0.8 g in near field earthquakes because of higher mode effects. Upon the generated fragility curves it was observed that middle and high structures have more acceptable performance and lower damage levels compared to low height structures in both near and far field seismic hazards.

  11. Wall Shear Stress Restoration in Dialysis Patient's Venous Stenosis: Elucidation via 3D CFD and Shape Optimization

    Science.gov (United States)

    Mahmoudzadeh Akherat, S. M. Javid; Cassel, Kevin; Hammes, Mary; Boghosian, Michael; Illinois Institute of Technology Team; University of Chicago Team

    2016-11-01

    Venous stenosis developed after the growth of excessive neointimal hyperplasia (NH) in chronic dialysis treatment is a major cause of mortality in renal failure patients. It has been hypothesized that the low wall shear stress (WSS) triggers an adaptive response in patients' venous system that through the growth of neointimal hyperplastic lesions restores WSS and transmural pressure, which also regulates the blood flow rate back to physiologically acceptable values which is violated by dialysis treatment. A strong coupling of three-dimensional CFD and shape optimization analyses were exploited to elucidate and forecast this adaptive response which correlates very well topographically with patient-specific clinical data. Based on the framework developed, a medical protocol is suggested to predict and prevent dialysis treatment failure in clinical practice. Supported by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health (R01 DK90769).

  12. Fracture Mechanics Models for Brittle Failure of Bottom Rails due to Uplift in Timber Frame Shear Walls

    Directory of Open Access Journals (Sweden)

    Joergen L. Jensen

    2016-01-01

    Full Text Available In partially anchored timber frame shear walls, hold-down devices are not provided; hence the uplift forces are transferred by the fasteners of the sheathing-to-framing joints into the bottom rail and via anchor bolts from the bottom rail into the foundation. Since the force in the anchor bolts and the sheathing-to-framing joints do not act in the same vertical plane, the bottom rail is subjected to tensile stresses perpendicular to the grain and splitting of the bottom rail may occur. This paper presents simple analytical models based on fracture mechanics for the analysis of such bottom rails. An existing model is reviewed and several alternative models are derived and compared qualitatively and with experimental data. It is concluded that several of the fracture mechanics models lead to failure load predictions which seem in sufficiently good agreement with the experimental results to justify their application in practical design.

  13. Application of the Hybrid Simulation Method for the Full-Scale Precast Reinforced Concrete Shear Wall Structure

    Directory of Open Access Journals (Sweden)

    Zaixian Chen

    2018-02-01

    Full Text Available The hybrid simulation (HS testing method combines physical test and numerical simulation, and provides a viable alternative to evaluate the structural seismic performance. Most studies focused on the accuracy, stability and reliability of the HS method in the small-scale tests. It is a challenge to evaluate the seismic performance of a twelve-story pre-cast reinforced concrete shear-wall structure using this HS method which takes the full-scale bottom three-story structural model as the physical substructure and the elastic non-linear model as the numerical substructure. This paper employs an equivalent force control (EFC method with implicit integration algorithm to deal with the numerical integration of the equation of motion (EOM and the control of the loading device. Because of the arrangement of the test model, an elastic non-linear numerical model is used to simulate the numerical substructure. And non-subdivision strategy for the displacement inflection point of numerical substructure is used to easily realize the simulation of the numerical substructure and thus reduce the measured error. The parameters of the EFC method are calculated basing on analytical and numerical studies and used to the actual full-scale HS test. Finally, the accuracy and feasibility of the EFC-based HS method is verified experimentally through the substructure HS tests of the pre-cast reinforced concrete shear-wall structure model. And the testing results of the descending stage can be conveniently obtained from the EFC-based HS method.

  14. Analysis of a Frame-Shear Wall Concrete Structure by Using Base Isolation and Evaluation of Structure-Soil Interaction

    Directory of Open Access Journals (Sweden)

    H. I. Polat

    2017-12-01

    Full Text Available A base isolation system is a type of earthquake-resistant structure design approach based on the principle of reducing a structure’s earthquake response rather than increasing the structure’s earthquake resistance capacity. Seismic base isolated structures have the ability to make large displacements relative to the level of insulation elements. This means that a large structure performs very small displacements between floors during an earthquake and exhibits a rigid body behavior. At this point, the earthquake forces acting on the structure decrease along with the floors. In this article a school building composed of frame-shear wall is resolved primarily with the traditional fixed base structure system, mode shapes are found and periods are obtained. For earthquake response analysis, earthquake loads are distributed to the floors using the equivalent seismic load method and structural elements experiencing capacity problems are found. Then, using the earthquake record, larger failure of cross sections and capacity problems are obtained compared to the first method. In the second stage, the same structure is dissolved again by placing the lead core rubber base isolators between the base and the vertical structural members. The periods of structures under earthquake load have increased significantly by utilizing base isolation, as a result of that spectral accelerations decreased. Thus, large decreases in the shear forces acting to the structure are determined and failures of cross sections are removed.

  15. Association between proximal internal carotid artery steno-occlusive disease and diffuse wall thickening in its petrous segment: a magnetic resonance vessel wall imaging study

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Xiaoyi; Li, Dongye [Capital Medical University and Beijing Institute for Brain Disorders, Center for Brain Disorders Research, Beijing (China); Tsinghua University School of Medicine, Center for Biomedical Imaging Research, Department of Biomedical Engineering, Beijing (China); Zhao, Huilin [Shanghai Jiao Tong University, Department of Radiology, Renji Hospital, School of Medicine, Shanghai (China); Chen, Zhensen; Qiao, Huiyu; He, Le; Li, Rui [Tsinghua University School of Medicine, Center for Biomedical Imaging Research, Department of Biomedical Engineering, Beijing (China); Cui, Yuanyuan [PLA General Hospital, Department of Radiology, Beijing (China); Zhou, Zechen [Philips Research China, Healthcare Department, Beijing (China); Yuan, Chun [Tsinghua University School of Medicine, Center for Biomedical Imaging Research, Department of Biomedical Engineering, Beijing (China); University of Washington, Department of Radiology, Seattle, WA (United States); Zhao, Xihai [Tsinghua University School of Medicine, Center for Biomedical Imaging Research, Department of Biomedical Engineering, Beijing (China); Beijing Institute for Brain Disorders, Center for Stroke, Beijing (China)

    2017-05-15

    Significant stenosis or occlusion in carotid arteries may lead to diffuse wall thickening (DWT) in the arterial wall of downstream. This study aimed to investigate the correlation between proximal internal carotid artery (ICA) steno-occlusive disease and DWT in ipsilateral petrous ICA. Symptomatic patients with atherosclerotic stenosis (>0%) in proximal ICA were recruited and underwent carotid MR vessel wall imaging. The 3D motion sensitized-driven equilibrium prepared rapid gradient-echo (3D-MERGE) was acquired for characterizing the wall thickness and longitudinal extent of the lesions in petrous ICA and the distance from proximal lesion to the petrous ICA. The stenosis degree in proximal ICA was measured on the time-of-flight (TOF) images. In total, 166 carotid arteries from 125 patients (mean age 61.0 ± 10.5 years, 99 males) were eligible for final analysis and 64 showed DWT in petrous ICAs. The prevalence of severe DWT in petrous ICA was 1.4%, 5.3%, 5.9%, and 80.4% in ipsilateral proximal ICAs with stenosis category of 1%-49%, 50%-69%, 70%-99%, and total occlusion, respectively. Proximal ICA stenosis was significantly correlated with the wall thickness in petrous ICA (r = 0.767, P < 0.001). Logistic regression analysis showed that proximal ICA stenosis was independently associated with DWT in ipsilateral petrous ICA (odds ratio (OR) = 2.459, 95% confidence interval (CI) 1.896-3.189, P < 0.001). Proximal ICA steno-occlusive disease is independently associated with DWT in ipsilateral petrous ICA. (orig.)

  16. Association between proximal internal carotid artery steno-occlusive disease and diffuse wall thickening in its petrous segment: a magnetic resonance vessel wall imaging study

    International Nuclear Information System (INIS)

    Chen, Xiaoyi; Li, Dongye; Zhao, Huilin; Chen, Zhensen; Qiao, Huiyu; He, Le; Li, Rui; Cui, Yuanyuan; Zhou, Zechen; Yuan, Chun; Zhao, Xihai

    2017-01-01

    Significant stenosis or occlusion in carotid arteries may lead to diffuse wall thickening (DWT) in the arterial wall of downstream. This study aimed to investigate the correlation between proximal internal carotid artery (ICA) steno-occlusive disease and DWT in ipsilateral petrous ICA. Symptomatic patients with atherosclerotic stenosis (>0%) in proximal ICA were recruited and underwent carotid MR vessel wall imaging. The 3D motion sensitized-driven equilibrium prepared rapid gradient-echo (3D-MERGE) was acquired for characterizing the wall thickness and longitudinal extent of the lesions in petrous ICA and the distance from proximal lesion to the petrous ICA. The stenosis degree in proximal ICA was measured on the time-of-flight (TOF) images. In total, 166 carotid arteries from 125 patients (mean age 61.0 ± 10.5 years, 99 males) were eligible for final analysis and 64 showed DWT in petrous ICAs. The prevalence of severe DWT in petrous ICA was 1.4%, 5.3%, 5.9%, and 80.4% in ipsilateral proximal ICAs with stenosis category of 1%-49%, 50%-69%, 70%-99%, and total occlusion, respectively. Proximal ICA stenosis was significantly correlated with the wall thickness in petrous ICA (r = 0.767, P < 0.001). Logistic regression analysis showed that proximal ICA stenosis was independently associated with DWT in ipsilateral petrous ICA (odds ratio (OR) = 2.459, 95% confidence interval (CI) 1.896-3.189, P < 0.001). Proximal ICA steno-occlusive disease is independently associated with DWT in ipsilateral petrous ICA. (orig.)

  17. Interacting effects of uniform flow, plane shear, and near-wall proximity on the heat and mass transfer of respiratory aerosols

    Energy Technology Data Exchange (ETDEWEB)

    Worth Longest, P. [Virginia Commonwealth University, Richmond, VA (United States). Dept. of Mechanical Engineering; Kleinstreuer, C. [North Carolina State University, Raleigh, NC (United States). Dept. of Mechanical and Aerospace Engineering

    2004-10-01

    Individual and interacting effects of uniform flow, plane shear, and near-wall proximity on spherical droplet heat and mass transfer have been assessed for low Reynolds number conditions beyond the creeping flow regime. Validated resolved volume simulations were used to compute heat and mass transfer surface gradients of two-dimensional axisymmetric droplets and three-dimensional spherical droplets near planar wall boundaries for conditions consistent with inhalable aerosols (5 {<=} d {<=} 300 {mu}m) in the upper respiratory tract. Results indicate that planar shear significantly impacts droplet heat and mass transfer for shear-based Reynolds numbers greater than 1, which occur for near-wall respiratory aerosols with diameters in excess of 50 {mu}m. Wall proximity is shown to significantly enhance heat and mass transfer due to conduction and diffusion at separation distances less than five particle diameters and for small Reynolds numbers. For the Reynolds number conditions of interest, significant non-linear effects arise due to the concurrent interaction of uniform flow and shear such that linear superposition of Sherwood or Nusselt number terms is not allowable. Based on the validated numeric simulations, multivariable Sherwood and Nusselt number correlations are provided to account for individual flow characteristics and concurrent non-linear interactions of uniform flow, planar shear, and near-wall proximity. These heat and mass transfer correlations can be applied to effectively compute condensation and evaporation rates of potentially toxic or therapeutic aerosols in the upper respiratory tract, where non-uniform flow and wall proximity are expected to significantly affect droplet transport, deposition, and vapor formation. (author)

  18. Shear-stress-induced structural arrangement of water molecules in nanoscale Couette flow with slipping at wall boundary

    International Nuclear Information System (INIS)

    Lin, Jau-Wen

    2014-01-01

    This study investigated the structuring of water molecules in a nanoscale Couette flow with the upper plate subjected to lateral forces with various magnitudes and water slipping against a metal wall. It was found that when the upper plate is subjected to a force, the water body deforms into a parallelepiped. Water molecules in the channel are then gradually arranged into lattice positions, creating a layered structure. The structural arrangement of water molecules is caused by the water molecules accommodating themselves to the increase in energy under the application of a lateral force on the moving plate. The ordering arrangement of water molecules increases the rotational degree of freedom, allowing the molecules to increase their Coulomb potential energy through polar rotation that accounts for the energy input through the upper plate. With a force continuously applied to the upper plate, the water molecules in contact with the upper plate move forward until slip between the water and upper plate occurs. The relation between the structural arrangement of water molecules, slip at the wall, and the shear force is studied. The relation between the slip and the locking/unlocking of water molecules to metal atoms is also studied

  19. SSI response of a typical shear wall structure. Appendix B. In-structure response spectra comparisons. Volume 2

    International Nuclear Information System (INIS)

    Johnson, J.J.; Schewe, E.C.; Maslenikov, O.R.

    1984-04-01

    The objectives of this study were two-fold: (1) develop building response calibration factors, i.e., factors which relate best estimate or median level response to responses calculated by selected design procedures. Soil-structure interaction was the phenomenon of interest because significant simplifications are frequently introduced in its treatment; and (2) the second objective can be viewed in the context of a question: what effect does placing an identical structure on different sites and with different foundation conditions have on structure response. The structure selected for this study is a part of the Zion AFT complex. Only the auxiliary, fuel-handling, and diesel generator buildings were studied. This structure is a connected group of shear-wall buildings constructed of reinforced concrete, typical of nuclear power plant structures. The bases of comparison for this study were structure responses: peak in-structure accelerations (27 components), and peak wall forces and moments (111 components). In-structure response spectra were also considered. This appendix contains in-structure response spectra comparisons in detail

  20. Development of a sensitive experimental set-up for LIF fuel wall film measurements in a pressure vessel

    Science.gov (United States)

    Schulz, Florian; Schmidt, Jürgen; Beyrau, Frank

    2015-05-01

    This paper focusses on fundamental investigations of fuel wall films, which are formed when the spray impinges on the piston or cylinder walls. To reproduce the wide range of operating conditions within homogeneously charged gasoline direct-injection engines, it is necessary to use a film thickness measurement method, which can be applied inside a high-pressure, high-temperature vessel. Hence, we developed a method based on laser-induced fluorescence that reaches: a precision better than 1 µm, a geometric resolution of 31 µm and a practical applicability for wall film thicknesses smaller 80 µm. To obtain accurate film thickness results, we provide a detailed description of the selection of the surrogate fuel isooctane with 3-pentanone as fluorescence tracer and the resulting assembly of the excitation source, beam expander, filters, camera and the essential image processing. Furthermore, advantages and disadvantages of other possible solutions are discussed. Earlier publications provide only little information about the accuracy of their calibration and measurement procedures. Therefore, we tested and compared three basic calibration methods to each other and provide an analysis of possible errors, such as the influence of the preferential evaporation of 3-pentanone. Finally, images of resulting wall films are presented, and practical considerations for the execution of the measurements like recording timings are discussed.

  1. Evaluation of thermal ratcheting of reactor vessel wall near the sodium surface

    International Nuclear Information System (INIS)

    Take, Kohji; Fujioka, Terutaka; Yano, Kazutaka

    1989-01-01

    Plastic ratcheting of reactor vessels may occur by an axially moving thermal gradient without primary stress. So there is a need to establish a proper prediction method for the plastic ratcheting. In this study, inelastic FEM analyses of reactor vessel model by using an advanced constitutive equation were carried out in order to comprehend plastic ratcheting behaviour of cylinder which subject to an axially moving thermal gradient. As a result of analyses, a basic mechanism of this ratcheting was found. And it also indicated that cyclic hardening behaviour will became important for development of evaluation method. (author)

  2. Application of kinematic vorticity and gold mineralization for the wall rock alterations of shear zone at Dungash gold mining, Central Eastern Desert, Egypt

    Science.gov (United States)

    Kassem, Osama M. K.; Abd El Rahim, Said H.; El Nashar, EL Said R.; AL Kahtany, Kaled M.

    2016-11-01

    The use of porphyroclasts rotating in a flowing matrix to estimate mean kinematic vorticity number (Wm) is important for quantifying the relative contributions of pure and simple shear in wall rocks alterations of shear zone at Dungash gold mine. Furthermore, it shows the relationship between the gold mineralization and deformation and also detects the orientation of rigid objects during progressive deformation. The Dungash gold mine area is situated in an EW-trending quartz vein along a shear zone in metavolcanic and metasedimentary host rocks in the Eastern Desert of Egypt. These rocks are associated with the major geologic structures which are attributed to various deformational stages of the Neoproterozoic basement rocks. We conclude that finite strain in the deformed rocks is of the same order of magnitude for all units of metavolcano-sedimentary rocks. The kinematic vorticity number for the metavolcanic and metasedimentary samples in the Dungash area range from 0.80 to 0.92, and together with the strain data suggest deviations from simple shear. It is concluded that nappe stacking occurred early during the underthrusting event probably by brittle imbrication and that ductile strain was superimposed on the nappe structure during thrusting. Furthermore, we conclude that disseminated mineralization, chloritization, carbonatization and silicification of the wall rocks are associated with fluids migrating along shearing, fracturing and foliation of the metamorphosed wall rocks.

  3. Age-related changes in aortic 3D blood flow velocities and wall shear stress: Implications for the identification of altered hemodynamics in patients with aortic valve disease

    NARCIS (Netherlands)

    van Ooij, Pim; Garcia, Julio; Potters, Wouter V.; Malaisrie, S. Chris; Collins, Jeremy D.; Carr, James C.; Markl, Michael; Barker, Alex J.

    2016-01-01

    To investigate age-related changes in peak systolic aortic 3D velocity and wall shear stress (WSS) in healthy controls and to investigate the importance of age-matching for 3D mapping of abnormal aortic hemodynamics in bicuspid aortic valve disease (BAV). 4D flow MRI (fields strengths = 1.5-3T;

  4. Design and material selection for ITER first wall/blanket, divertor and vacuum vessel

    Energy Technology Data Exchange (ETDEWEB)

    Ioki, K.; Barabash, V.; Cardella, A.; Elio, F.; Gohar, Y.; Janeschitz, G.; Johnson, G.; Kalinin, G.; Lousteau, D.; Onozuka, M.; Parker, R.; Sannazzaro, G.; Tivey, R. [ITER JCT, Garching (Germany)

    1998-10-01

    Design and R and D have progressed on the ITER vacuum vessel, shielding and breeding blankets, and the divertor. The principal materials have been selected and the fabrication methods selected for most of the components based on design and R and D results. The resulting design changes are discussed for each system. (orig.) 11 refs.

  5. Design and material selection for ITER first wall/blanket, divertor and vacuum vessel

    Science.gov (United States)

    Ioki, K.; Barabash, V.; Cardella, A.; Elio, F.; Gohar, Y.; Janeschitz, G.; Johnson, G.; Kalinin, G.; Lousteau, D.; Onozuka, M.; Parker, R.; Sannazzaro, G.; Tivey, R.

    1998-10-01

    Design and R&D have progressed on the ITER vacuum vessel, shielding and breeding blankets, and the divertor. The principal materials have been selected and the fabrication methods selected for most of the components based on design and R&D results. The resulting design changes are discussed for each system.

  6. Analysis of three ex-vessel loss-of-coolant accidents in the first wall cooling system of NET/ITER

    International Nuclear Information System (INIS)

    Komen, E.M.J.; Koning, H.

    1993-01-01

    An ex-vessel LOCA may be caused by a rupture of a cooling pipe located outside the vacuum vessel. No plasma shutdown and no other counteractions have been assumed in order to study the worst case conditions of the accidents. The next three ex-vessel LOCAs in the primary cooling system of the first wall have been analysed: 1. a large break ex-vessel LOCA caused by a rupture of the cold leg (inner diameter 0.314 m) of the main circuit; 2. an intermediate break ex-vessel LOCA caused by a rupture of a sector inlet feeder (inner diameter 0.158 m); 3. an intermediate break ex-vessel LOCA caused by a rupture of the surge line (inner diameter 0.180 m) of the pressurizer. The analyses have been performed using the thermal-hydraulic system analysis code RELAP5/MOD3. In the first two scenarios, melting in the first wall starts about 90 s after break initiation. In the third scenario, melting in the first wall start about 323 s after break initiation. Special emphasis has been paid to the characteristics of the break flows, the transient thermal-hydraulic behaviour of the cooling system, and the temperature development in the first wall. (orig.)

  7. Distribution and natural course of intracranial vessel wall lesions in patients with ischemic stroke or TIA at 7.0 tesla MRI

    Energy Technology Data Exchange (ETDEWEB)

    Kolk, Anja G. van der; Luijten, Peter R.; Hendrikse, Jeroen [University Medical Center Utrecht, Department of Radiology, Postbox 85500, Utrecht (Netherlands); Zwanenburg, Jaco J.M. [University Medical Center Utrecht, Department of Radiology, Postbox 85500, Utrecht (Netherlands); University Medical Center Utrecht, Image Sciences Institute, Utrecht (Netherlands); Brundel, Manon; Biessels, Geert Jan [University Medical Center Utrecht, Department of Neurology, Utrecht (Netherlands); Visser, Fredy [University Medical Center Utrecht, Department of Radiology, Postbox 85500, Utrecht (Netherlands); Philips Healthcare, Best (Netherlands)

    2015-06-01

    Previous studies using intracranial vessel wall MRI techniques showed that over 50 % of patients with ischemic stroke or TIA had one or more intracranial vessel wall lesions. In the current study, we assessed the preferential location of these lesions within the intracranial arterial tree and their potential changes over time in these patient groups. Forty-nine patients with ischemic stroke (n = 25) or TIA (n = 24) of the anterior cerebral circulation underwent 7.0 T MRI, including a T{sub 1}-weighted magnetization-preparation inversion recovery turbo-spin-echo (MPIR-TSE) sequence within one week and approximately one month after symptom onset. Intracranial vessel wall lesions were scored for multiple locations within the arterial tree and differences between one-week and one-month images. At baseline, 132 intracranial vessel wall lesions were found in 41 patients (84 %), located primarily in the anterior cerebral circulation (74 %), with a preferential location in the distal internal carotid artery and M1 and M2 segments of the middle cerebral artery. During follow-up, presence or enhancement patterns changed in 14 lesions (17 %). A large burden of intracranial vessel wall lesions was found in both the anterior and posterior cerebral circulation. Most lesions were found to be relatively stable, possibly indicating a more generalized atherosclerotic process. (orig.)

  8. Simulation of LLCB TBM in-vessel first wall coolant break into ITER vacuum vessel by using RELAP/MOD3.4

    International Nuclear Information System (INIS)

    Tony Sandeep, K.; Chaudhari, Vilas; Rajendra Kumar, E.; Dutta, Anu; Singh, R.K.

    2013-06-01

    To prove Test Blanket Module (TBM) safety in International Thermonuclear Experimental Reactor (ITER), various accident scenarios are postulated . One of the postulated initiating events to be analysed is TBM First wall (FW) coolant leak in ITER Vacuum vessel (VV). This accident has been classified as a reference event for the TBM (probability of occurrence >1 E -06 /a). The postulated accident occurs as a result of small leak of TBM FW helium into ITER vacuum vessel (VV), caused by the TBM weld failure. The ingress of this TBM FW helium into ITER plasma induces intense plasma disruption that deposits 1.8 MJ/m 2 of plasma stored thermal energy onto the TBM FW over a period of 1 sec in duration (assumption). Runaway electrons in this process are lost from plasma current channel and cause multiple TBM and ITER FW cooling tube failures within 10 cm torriodal strip. The size of the break is identified as double ended rupture of all coolant channels within this strip around the reactor. For LLCB TBM this represents failure of 4 FW channels. The size of ITER FW break is 0.02 m 2 . Consequently, a simultaneous blow down of TBM FW helium and ITER FW water occurs, injecting helium and water into VV. This pressurisation causes the activation of VV pressure suppressions system and ingress of water into VV. This pressurisation causes the VV pressure suppressions system (VVPSS) to open in an attempt to contain the pressure below the safety limit of 0.2 MPa. This report is intended to do the above accident analysis and assessment of active components of TBM using RELAP code and hence prove its safety in ITER environment. (author)

  9. Whole-brain intracranial vessel wall imaging at 3 Tesla using cerebrospinal fluid-attenuated T1-weighted 3D turbo spin echo.

    Science.gov (United States)

    Fan, Zhaoyang; Yang, Qi; Deng, Zixin; Li, Yuxia; Bi, Xiaoming; Song, Shlee; Li, Debiao

    2017-03-01

    Although three-dimensional (3D) turbo spin echo (TSE) with variable flip angles has proven to be useful for intracranial vessel wall imaging, it is associated with inadequate suppression of cerebrospinal fluid (CSF) signals and limited spatial coverage at 3 Tesla (T). This work aimed to modify the sequence and develop a protocol to achieve whole-brain, CSF-attenuated T 1 -weighted vessel wall imaging. Nonselective excitation and a flip-down radiofrequency pulse module were incorporated into a commercial 3D TSE sequence. A protocol based on the sequence was designed to achieve T 1 -weighted vessel wall imaging with whole-brain spatial coverage, enhanced CSF-signal suppression, and isotropic 0.5-mm resolution. Human volunteer and pilot patient studies were performed to qualitatively and quantitatively demonstrate the advantages of the sequence. Compared with the original sequence, the modified sequence significantly improved the T 1 -weighted image contrast score (2.07 ± 0.19 versus 3.00 ± 0.00, P = 0.011), vessel wall-to-CSF contrast ratio (0.14 ± 0.16 versus 0.52 ± 0.30, P = 0.007) and contrast-to-noise ratio (1.69 ± 2.18 versus 4.26 ± 2.30, P = 0.022). Significant improvement in vessel wall outer boundary sharpness was observed in several major arterial segments. The new 3D TSE sequence allows for high-quality T 1 -weighted intracranial vessel wall imaging at 3 T. It may potentially aid in depicting small arteries and revealing T 1 -mediated high-signal wall abnormalities. Magn Reson Med 77:1142-1150, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  10. Imaging the Intracranial Atherosclerotic Vessel Wall Using 7T MRI : Initial Comparison with Histopathology

    NARCIS (Netherlands)

    van der Kolk, A. G.; Zwanenburg, J. J. M.; Denswil, N. P.; Vink, A.; Spliet, W. G. M.; Daemen, M. J. A. P.; Visser, F.; Klomp, D. W. J.; Luijten, P. R.; Hendrikse, J.

    In this preliminary study, 7T imaging was capable of identifying not only intracranial wall thickening but different plaque components such as foamy macrophages and collagen. Signal heterogeneity was typical of advanced atherosclerotic disease. BACKGROUND AND PURPOSE: Several studies have attempted

  11. 1-Dimensional simulation of thermal annealing in a commercial nuclear power plant reactor pressure vessel wall section

    International Nuclear Information System (INIS)

    Nakos, J.T.; Rosinski, S.T.; Acton, R.U.

    1994-11-01

    The objective of this work was to provide experimental heat transfer boundary condition and reactor pressure vessel (RPV) section thermal response data that can be used to benchmark computer codes that simulate thermal annealing of RPVS. This specific protect was designed to provide the Electric Power Research Institute (EPRI) with experimental data that could be used to support the development of a thermal annealing model. A secondary benefit is to provide additional experimental data (e.g., thermal response of concrete reactor cavity wall) that could be of use in an annealing demonstration project. The setup comprised a heater assembly, a 1.2 in x 1.2 m x 17.1 cm thick [4 ft x 4 ft x 6.75 in] section of an RPV (A533B ferritic steel with stainless steel cladding), a mockup of the open-quotes mirrorclose quotes insulation between the RPV and the concrete reactor cavity wall, and a 25.4 cm [10 in] thick concrete wall, 2.1 in x 2.1 in [10 ft x 10 ft] square. Experiments were performed at temperature heat-up/cooldown rates of 7, 14, and 28 degrees C/hr [12.5, 25, and 50 degrees F/hr] as measured on the heated face. A peak temperature of 454 degrees C [850 degrees F] was maintained on the heated face until the concrete wall temperature reached equilibrium. Results are most representative of those RPV locations where the heat transfer would be 1-dimensional. Temperature was measured at multiple locations on the heated and unheated faces of the RPV section and the concrete wall. Incident heat flux was measured on the heated face, and absorbed heat flux estimates were generated from temperature measurements and an inverse heat conduction code. Through-wall temperature differences, concrete wall temperature response, heat flux absorbed into the RPV surface and incident on the surface are presented. All of these data are useful to modelers developing codes to simulate RPV annealing

  12. Gas Near a Wall: Shortened Mean Free Path, Reduced Viscosity, and the Manifestation of the Knudsen Layer in the Navier-Stokes Solution of a Shear Flow

    Science.gov (United States)

    Abramov, Rafail V.

    2018-06-01

    For the gas near a solid planar wall, we propose a scaling formula for the mean free path of a molecule as a function of the distance from the wall, under the assumption of a uniform distribution of the incident directions of the molecular free flight. We subsequently impose the same scaling onto the viscosity of the gas near the wall and compute the Navier-Stokes solution of the velocity of a shear flow parallel to the wall. Under the simplifying assumption of constant temperature of the gas, the velocity profile becomes an explicit nonlinear function of the distance from the wall and exhibits a Knudsen boundary layer near the wall. To verify the validity of the obtained formula, we perform the Direct Simulation Monte Carlo computations for the shear flow of argon and nitrogen at normal density and temperature. We find excellent agreement between our velocity approximation and the computed DSMC velocity profiles both within the Knudsen boundary layer and away from it.

  13. Characterization of atherosclerotic disease in thoracic aorta: A 3D, multicontrast vessel wall imaging study

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Changwu [Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing (China); Department of Radiology, The Second Clinical Medical College, Yangzhou University, Yangzhou (China); Qiao, Huiyu; He, Le [Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing (China); Yuan, Chun [Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing (China); Department of Radiology, University of Washington, Seattle, WA (United States); Chen, Huijun; Zhang, Qiang; Li, Rui [Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing (China); Wang, Wei; Du, Fang [Department of Radiology, The Second Clinical Medical College, Yangzhou University, Yangzhou (China); Li, Cheng, E-mail: cjr.licheng@vip.163.com [Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing (China); Zhao, Xihai, E-mail: xihaizhao@tsinghua.edu.cn [Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing (China)

    2016-11-15

    Purpose: To investigate the characteristics of plaque in the thoracic aorta using three dimensional multicontrast magnetic resonance imaging. Materials and methods: Elderly subjects (≥60 years) were recruited in this study. Thoracic aorta was imaged on a 3.0T MR scanner by acquiring multicontrast sequences. The plaque burden was evaluated by measuring lumen area, wall area, wall thickness, and normalized wall index. The presence or absence of plaque and intraplaque hemorrhage (IPH)/mural thrombus (MT) were identified. The characteristics of atherosclerosis among different thoracic aorta segments (AAO: ascending aorta; AOA: aortic arch, and DOA: descending aorta) were determined. Results: Of 66 recruited subjects (mean age 72.3 ± 6.2 years, 30 males), 55 (83.3%) had plaques in the thoracic aorta. The prevalence of plaque in AAO, AOA, and DAO was 5.4%, 72.7%, and 71.2%, respectively. In addition, 21.2% of subjects were found to have lesions with IPH/MT in the thoracic aorta. The prevalence of IPH/MT in segment of AAO, AOA and DAO was 0%, 13.6%, and 12.1%, respectively. The aortic wall showed the highest NWI in DAO (34.1% ± 4.8%), followed by AOA (31.2% ± 5%), and AAO (26.8% ± 3.3%) (p < 0.001). Conclusion: Three dimensional multicontrast MR imaging is capable of characterizing atherosclerotic plaques in the thoracic aorta. The findings of high prevalence of plaques and the presence of high risk plaques in the thoracic aorta suggest early screening for aortic vulnerable lesions in the elderly.

  14. Characterization of atherosclerotic disease in thoracic aorta: A 3D, multicontrast vessel wall imaging study

    International Nuclear Information System (INIS)

    Zhou, Changwu; Qiao, Huiyu; He, Le; Yuan, Chun; Chen, Huijun; Zhang, Qiang; Li, Rui; Wang, Wei; Du, Fang; Li, Cheng; Zhao, Xihai

    2016-01-01

    Purpose: To investigate the characteristics of plaque in the thoracic aorta using three dimensional multicontrast magnetic resonance imaging. Materials and methods: Elderly subjects (≥60 years) were recruited in this study. Thoracic aorta was imaged on a 3.0T MR scanner by acquiring multicontrast sequences. The plaque burden was evaluated by measuring lumen area, wall area, wall thickness, and normalized wall index. The presence or absence of plaque and intraplaque hemorrhage (IPH)/mural thrombus (MT) were identified. The characteristics of atherosclerosis among different thoracic aorta segments (AAO: ascending aorta; AOA: aortic arch, and DOA: descending aorta) were determined. Results: Of 66 recruited subjects (mean age 72.3 ± 6.2 years, 30 males), 55 (83.3%) had plaques in the thoracic aorta. The prevalence of plaque in AAO, AOA, and DAO was 5.4%, 72.7%, and 71.2%, respectively. In addition, 21.2% of subjects were found to have lesions with IPH/MT in the thoracic aorta. The prevalence of IPH/MT in segment of AAO, AOA and DAO was 0%, 13.6%, and 12.1%, respectively. The aortic wall showed the highest NWI in DAO (34.1% ± 4.8%), followed by AOA (31.2% ± 5%), and AAO (26.8% ± 3.3%) (p < 0.001). Conclusion: Three dimensional multicontrast MR imaging is capable of characterizing atherosclerotic plaques in the thoracic aorta. The findings of high prevalence of plaques and the presence of high risk plaques in the thoracic aorta suggest early screening for aortic vulnerable lesions in the elderly.

  15. Accelerated whole brain intracranial vessel wall imaging using black blood fast spin echo with compressed sensing (CS-SPACE).

    Science.gov (United States)

    Zhu, Chengcheng; Tian, Bing; Chen, Luguang; Eisenmenger, Laura; Raithel, Esther; Forman, Christoph; Ahn, Sinyeob; Laub, Gerhard; Liu, Qi; Lu, Jianping; Liu, Jing; Hess, Christopher; Saloner, David

    2018-06-01

    Develop and optimize an accelerated, high-resolution (0.5 mm isotropic) 3D black blood MRI technique to reduce scan time for whole-brain intracranial vessel wall imaging. A 3D accelerated T 1 -weighted fast-spin-echo prototype sequence using compressed sensing (CS-SPACE) was developed at 3T. Both the acquisition [echo train length (ETL), under-sampling factor] and reconstruction parameters (regularization parameter, number of iterations) were first optimized in 5 healthy volunteers. Ten patients with a variety of intracranial vascular disease presentations (aneurysm, atherosclerosis, dissection, vasculitis) were imaged with SPACE and optimized CS-SPACE, pre and post Gd contrast. Lumen/wall area, wall-to-lumen contrast ratio (CR), enhancement ratio (ER), sharpness, and qualitative scores (1-4) by two radiologists were recorded. The optimized CS-SPACE protocol has ETL 60, 20% k-space under-sampling, 0.002 regularization factor with 20 iterations. In patient studies, CS-SPACE and conventional SPACE had comparable image scores both pre- (3.35 ± 0.85 vs. 3.54 ± 0.65, p = 0.13) and post-contrast (3.72 ± 0.58 vs. 3.53 ± 0.57, p = 0.15), but the CS-SPACE acquisition was 37% faster (6:48 vs. 10:50). CS-SPACE agreed with SPACE for lumen/wall area, ER measurements and sharpness, but marginally reduced the CR. In the evaluation of intracranial vascular disease, CS-SPACE provides a substantial reduction in scan time compared to conventional T 1 -weighted SPACE while maintaining good image quality.

  16. Investigation of Deterioration Behavior of Hysteretic Loops in Nonlinear Static Procedure Analysis of Concrete Structures with Shear Walls

    International Nuclear Information System (INIS)

    Ghodrati Amiri, G.; Amidi, S.; Khorasani, M.

    2008-01-01

    In the recent years, scientists developed the seismic rehabilitation of structures and their view points were changed from sufficient strength to the performance of structures (Performance Base Design) to prepare a safe design. Nonlinear Static Procedure analysis (NSP) or pushover analysis is a new method that is chosen for its speed and simplicity in calculations. 'Seismic Rehabilitation Code for Existing Buildings' and FEMA 356 considered this method. Result of this analysis is a target displacement that is the base of the performance and rehabilitation procedure of the structures. Exact recognition of that displacement could develop the workability of pushover analysis. In these days, Nonlinear Dynamic Analysis (NDP) is only method can exactly apply the seismic ground motions. In this case because it consumes time, costs very high and is more difficult than other methods, is not applicable as much as NSP. A coefficient used in NSP for determining the target displacement is C2 (Stiffness and Strength Degradations Coefficient) and is applicable for correcting the errors due to eliminating the stiffness and strength degradations in hysteretic loops. In this study it has been tried to analysis three concrete frames with shear walls by several accelerations that scaled according to FEMA 273 and FEMA 356. These structures were designed with Iranian 2800 standard (vers.3). Finally after the analyzing by pushover method and comparison results with dynamic analysis, calculated C2 was comprised with values in rehabilitation codes

  17. Production of functional proteins: balance of shear stress and gravity

    Science.gov (United States)

    Goodwin, Thomas John (Inventor); Hammond, Timothy Grant (Inventor); Kaysen, James Howard (Inventor)

    2011-01-01

    A method for the production of functional proteins including hormones by renal cells in a three dimensional culturing process responsive to shear stress uses a rotating wall vessel. Natural mixture of renal cells expresses the enzyme 1-.alpha.-hydroxylase which can be used to generate the active form of vitamin D: 1,25-diOH vitamin D.sub.3. The fibroblast cultures and co-culture of renal cortical cells express the gene for erythropoietin and secrete erythropoietin into the culture supernatant. Other shear stress response genes are also modulated by shear stress, such as toxin receptors megalin and cubulin (gp280). Also provided is a method of treating an in-need individual with the functional proteins produced in a three dimensional co-culture process responsive to shear stress using a rotating wall vessel.

  18. Finite element analysis of the design and manufacture of thin-walled pressure vessels used as aerosol cans

    Science.gov (United States)

    Abdussalam, Ragba Mohamed

    Thin-walled cylinders are used extensively in the food packaging and cosmetics industries. The cost of material is a major contributor to the overall cost and so improvements in design and manufacturing processes are always being sought. Shape optimisation provides one method for such improvements. Aluminium aerosol cans are a particular form of thin-walled cylinder with a complex shape consisting of truncated cone top, parallel cylindrical section and inverted dome base. They are manufactured in one piece by a reverse-extrusion process, which produces a vessel with a variable thickness from 0.31 mm in the cylinder up to 1.31 mm in the base for a 53 mm diameter can. During manufacture, packaging and charging, they are subjected to pressure, axial and radial loads and design calculations are generally outside the British and American pressure vessel codes. 'Design-by-test' appears to be the favoured approach. However, a more rigorous approach is needed in order to optimise the designs. Finite element analysis (FEA) is a powerful tool for predicting stress, strain and displacement behaviour of components and structures. FEA is also used extensively to model manufacturing processes. In this study, elastic and elastic-plastic FEA has been used to develop a thorough understanding of the mechanisms of yielding, 'dome reversal' (an inherent safety feature, where the base suffers elastic-plastic buckling at a pressure below the burst pressure) and collapse due to internal pressure loading and how these are affected by geometry. It has also been used to study the buckling behaviour under compressive axial loading. Furthermore, numerical simulations of the extrusion process (in order to investigate the effects of tool geometry, friction coefficient and boundary conditions) have been undertaken. Experimental verification of the buckling and collapse behaviours has also been carried out and there is reasonable agreement between the experimental data and the numerical

  19. 3-D MDT with spherical targets by bilinear interpolation for determining blood velocity profiles including the vessel wall effect

    Science.gov (United States)

    Choomphon-anomakhun, Natthaphon; Natenapit, Mayuree

    2018-02-01

    A numerical simulation of three-dimensional (3-D) implant assisted-magnetic drug targeting (IA-MDT) using ferromagnetic spherical targets, including the effect from the vessel wall on the blood flow, is presented. The targets were implanted within arterioles and subjected to an externally uniform applied magnetic field in order to increase the effectiveness of targeting magnetic drug carrier particles (MDCPs). The capture area (As) of the MDCPs was determined by inspection of the particle trajectories simulated from the particle equations of motion. The blood flow velocities at any particle position around the target were obtained by applying bilinear interpolation to the numerical blood velocity data. The effects on As of the type of ferromagnetic materials in the targets and MDCPs, average blood flow rates, mass fraction of the ferromagnetic material in the MDCPs, average radii of MDCPs (Rp) and the externally applied magnetic field strength (μ0H0) were evaluated. Furthermore, the appropriate μ0H0 and Rp for the IA-MDT design is suggested. In the case of the SS409 target and magnetite MDCPs, dimensionless capture areas ranging from 4.1- to 12.4 and corresponding to particle capture efficiencies of 31-94% were obtained with Rp ranging from 100- to 500 nm, weight fraction of 80%, μ0H0 of 0.6 T and an average blood flow rate of 0.01 ms-1. In addition, the more general 3-D modelling of IA-MDT in this work is applicable to IA-MDT using spherical targets implanted within blood vessels for both laminar and potential blood flows including the wall effect.

  20. 18F-fluoroethylcholine uptake in arterial vessel walls and cardiovascular risk factors. Correlation in a PET-CT study

    International Nuclear Information System (INIS)

    Foerster, Stefan; Rominger, A.; Cumming, P.; Bartenstein, P.; Hacker, M.; Saam, T.; Nikolaou, K.; Reiser, M.F.; Wolpers, S.; Univ. Muenchen

    2010-01-01

    Fluorine-labelled choline derivatives were recently suggested as agents for visualizing vulnerable atherosclerotic plaques. We therefore aimed to evaluate the association between 18 F-fluorethylcholine (FEC) uptake in the wall of large arteries, where calcification was also measured, with the presence of cardiovascular risk factors and occurrence of prior cardiovascular events. Detailed clinical information, including common cardiovascular risk factors, was obtained retrospectively in 60 prostate cancer patients examined with whole-body FEC PET-CT. In each patient, we calculated the mean blood pool-corrected SUV, as well as the mean target-to-background ratio (TBR), in addition to the sum of calcified plaques (CP sum ) from six major vessels: ascending and descending aorta, aortic arch, abdominal aorta, and both iliac arteries. As reported previously, the CP sum correlated significantly with cardiovascular risk factors, in contrast to mean SUV or TBR scores, which did not show any significance with the presence of cardiovascular risk factors. There was no correlation between CP sum , mean TBR or SUV, nor was there any significant association of CP sum , mean TBR or SUV with the prior occurrence of cardio- or cerebrovascular events. Contrary to a recent report, we found in our rather large cohort of elderly prostate cancer patients no significant association between FEC uptake in large vessels and atherosclerotic plaque burden, or the presence of cardiovascular risk factors. In line with prior reports on structural changes in vessels, increased calcified atherosclerotic plaque burden was strongly associated with the occurrence of common cardiovascular risk factors. (orig.)

  1. Detection of a coronary artery vessel wall: performance of 0.3 mm fine-cell detector computed tomography-a phantom study

    International Nuclear Information System (INIS)

    Yamada, Minoru; Jinzaki, Masahiro; Tanami, Yutaka; Matsumoto, Kazuhiro; Ueno, Akihisa; Kuribayashi, Sachio; Nukui, Masatake; Imai, Yasuhiro; Ishihara, Yotaro; Nishide, Akihiko; Sasaki, Kosuke

    2011-01-01

    The purpose of this study was to evaluate whether experimental fine-cell detector computed tomography with a 0.3125 mm cell (0.3 mm cell CT) can improve the detection of coronary vessel walls compared with conventional 64-slice computed tomography with a 0.625 mm cell (0.6 mm cell CT). A coronary vessel wall phantom was scanned using 0.6 mm cell CT and 0.3 mm cell CT. The data for 0.3 mm cell CT were obtained using four protocols: a radiation dose equal, double, triple or quadruple that were used in the 0.6 mm cell CT protocol. The detectable size of the vessel wall was assessed based on the first and second derivative functions, and the minimum measurable values were compared using a paired t-test. As a result, the minimum detectable wall thickness of 0.6 mm cell CT (1.5 mm) was significantly larger than that of 0.3 mm cell CT performed using the triple- and quadruple-dose protocols (0.9 mm) and the double-dose protocol (1.1 mm). The difference in the minimum detectable vessel wall thickness measured using 0.6 mm cell CT (1.5 ± 0.1 mm) and 0.3 mm cell CT (0.9 ± 0.1 mm, 1.1 ± 0.2 mm) was significant (p < 0.01). We concluded that 0.3 mm cell CT improved the detection of coronary vessel walls when a more than double-dose protocol was used compared with 0.6 mm cell CT.

  2. Detection of vessel wall calcifications in vertebral arteries using susceptibility weighted imaging

    Energy Technology Data Exchange (ETDEWEB)

    Adams, Lisa C.; Boeker, Sarah M.; Bender, Yvonne Y.; Fallenberg, Eva M.; Wagner, Moritz; Hamm, Bernd; Makowski, Marcus R. [Department of Radiology, Charite, Berlin (Germany); Liebig, Thomas [Department of Neuroradiology, Charite, Berlin (Germany)

    2017-09-15

    Calcification of the brain supplying arteries has been linked to an increased risk for cerebrovascular disease. The purpose of this study was to test the potential of susceptibility weighted MR imaging (SWMR) for the detection of vertebral artery calcifications, based on CT as a reference standard. Four hundred seventy-four patients, who had received head CT and 1.5 T MR scans with SWMR, including the distal vertebral artery, between January 2014 and December 2016, were retrospectively evaluated and 389 patients were included. Sensitivity and specificity for the detection of focal calcifications and intra- and interobserver agreement were calculated for SWMR and standard MRI, using CT as a standard of reference. The diameter of vertebral artery calcifications was used to assess correlations between imaging modalities. Furthermore, the degree of vessel stenosis was determined in 30 patients, who had received an additional angiography. On CT scans, 40 patients showed a total of 52 vertebral artery calcifications. While SWMR reached a sensitivity of 94% (95% CI 84-99%) and a specificity of 97% (95% CI 94-98%), standard MRI yielded a sensitivity of 33% (95% CI 20-46%), and a specificity of 93% (95% CI 90-96%). Linear regression analysis of size measurements confirmed a close correlation between SWMR and CT measurements (R {sup 2} = 0.74, p < 0.001). Compared to standard MRI (ICC = 0.52; CI 0.45-0.59), SWMR showed a higher interobserver agreement for calcification measurements (ICC = 0.84; CI 0.81-0.87). For detection of distal vertebral artery calcifications, SWMR demonstrates a performance comparable to CT and considerably higher than conventional MRI. (orig.)

  3. Strengthening of Shear Walls

    DEFF Research Database (Denmark)

    Hansen, Christian Skodborg

    The theory for concrete structures strengthened with fiber reinforced polymer materials has been developing for approximately two decades, and there are at the present time numerous guidelines covering strengthening of many commonly encountered structural building elements. Strengthening of in...... that describes a unit width strip of a strengthened disk. The unit width strip is named a strengthened concrete tension member and contains a single tensile crack and four debonding cracks. Analysis of the member results in closed form expressions for the load-crack opening relationship. Further analysis...... of the response, results in the ability to determine and characterize the two-way crack propagation, i.e. the relationship between tensile cracking in the concrete and interface debonding between strengthening and concrete. Using the load-crack opening relationship from the strengthened concrete tension member...

  4. Structural design of shield-integrated thin-wall vacuum vessel and manufacturing qualification tests for International Thermonuclear Experimental Reactor (ITER)

    International Nuclear Information System (INIS)

    Shimizu, Katsusuke; Shibui, Masanao; Koizumi, Koichi; Kanamori, Naokazu; Nishio, Satoshi; Sasaki, Takashi; Tada, Eisuke

    1992-09-01

    Conceptual design of shield-integrated thin-wall vacuum vessel has been done for ITER (International Thermonuclear Experimental Reactor). The vacuum vessel concept is based on a thin-double-wall structure, which consists of inner and outer plates and rib stiffeners. Internal shielding structures, which provide neutron irradiation shielding to protect TF coils, are set up between the inner plate and the outer plate of the vessel to avoid complexity of machine systems such as supporting systems of blanket modules. The vacuum vessel is assembled/disassembled by remote handling, so that welding joints are chosen as on-site joint method from reliability of mechanical strength. From a view point of assembling TF coils, the vacuum vessel is separated at the side of port, and is divided into 32 segments similar to the ITER-CDA reference design. Separatrix sweeping coils are located in the vacuum vessel to reduce heat fluxes onto divertor plates. Here, the coil structure and attachment to the vacuum vessel have been investigated. A sectorized saddle-loop coil is available for assembling and disassembling the coil. To support electromagnetic loads on the coils, they are attached to the groove in the vacuum vessel by welding. Flexible multi-plate supporting structure (compression-type gravity support), which was designed during CDA, is optimized by investigating buckling and frequency response properties, and concept on manufacturing and fabrication of the gravity support are proposed. Partial model of the vacuum vessel is manufactured for trial, so that fundamental data on welding and fabrication are obtained. From mechanical property tests of weldment and partial models, mechanical intensity and behaviors of the weldment are obtained. Informations on FEM-modeling are obtained by comparing analysis results with experimental results. (author)

  5. Flow and wall shear stress in end-to-side and side-to-side anastomosis of venous coronary artery bypass grafts

    Directory of Open Access Journals (Sweden)

    Poulikakos Dimos

    2007-09-01

    Full Text Available Abstract Purpose Coronary artery bypass graft (CABG surgery represents the standard treatment of advanced coronary artery disease. Two major types of anastomosis exist to connect the graft to the coronary artery, i.e., by using an end-to-side or a side-to-side anastomosis. There is still controversy because of the differences in the patency rates of the two types of anastomosis. The purpose of this paper is to non-invasively quantify hemodynamic parameters, such as mass flow and wall shear stress (WSS, in end-to-side and side-to-side anastomoses of patients with CABG using computational fluid dynamics (CFD. Methods One patient with saphenous CABG and end-to-side anastomosis and one patient with saphenous CABG and side-to-side anastomosis underwent 16-detector row computed tomography (CT. Geometric models of coronary arteries and bypasses were reconstructed for CFD analysis. Blood flow was considered pulsatile, laminar, incompressible and Newtonian. Peri-anastomotic mass flow and WSS were quantified and flow patterns visualized. Results CFD analysis based on in-vivo CT coronary angiography data was feasible in both patients. For both types of CABG, flow patterns were characterized by a retrograde flow into the native coronary artery. WSS variations were found in both anastomoses types, with highest WSS values at the heel and lowest WSS values at the floor of the end-to-side anastomosis. In contrast, the highest WSS values of the side-to-side anastomosis configuration were found in stenotic vessel segments and not in the close vicinity of the anastomosis. Flow stagnation zones were found in end-to-side but not in side-to-side anastomosis, the latter also demonstrating a smoother stream division throughout the cardiac cycle. Conclusion CFD analysis of venous CABG based on in-vivo CT datasets in patients was feasible producing qualitative and quantitative information on mass flow and WSS. Differences were found between the two types of anastomosis

  6. [Morphological signs of mitochondrial cytopathy in skeletal muscles and micro-vessel walls in a patient with cerebral artery dissection associated with MELAS syndrome].

    Science.gov (United States)

    Sakharova, A V; Kalashnikova, L A; Chaĭkovskaia, R P; Mir-Kasimov, M F; Nazarova, M A; Pykhtina, T N; Dobrynina, L A; Patrusheva, N L; Patrushev, L I; Protskiĭ, S V

    2012-01-01

    Skin and muscles biopsy specimens of a patient harboring A3243G mutation in mitochondrial DNA, with dissection of internal carotid and vertebral arteries, associated with MELAS were studied using histochemical and electron-microscopy techniques. Ragged red fibers, regional variability of SDH histochemical reaction, two types of morphologically atypical mitochondria and their aggregation were found in muscle. There was correlation between SDH histochemical staining and number of mitochondria revealed by electron microscopy in muscle tissue. Similar mitochondrial abnormality, their distribution and cell lesions followed by extra-cellular matrix mineralization were found in the blood vessel walls. In line with generalization of cytopathy process caused by gene mutation it can be supposed that changes found in skin and muscle microvessels also exist in large cerebral vessels causing the vessel wall "weakness", predisposing them to dissection.

  7. Mathematical Modeling of Bingham Plastic Model of Blood Flow Through Stenotic Vessel

    OpenAIRE

    S.R. Verma

    2014-01-01

    The aim of the present paper is to study the axially symmetric, laminar, steady, one-dimensional flow of blood through narrow stenotic vessel. Blood is considered as Bingham plastic fluid. The analytical results such as pressure drop, resistance to flow and wall shear stress have been obtained. Effect of yield stress and shape of stenosis on resistance to flow and wall shear stress have been discussed through tables and graphically. It has been shown that resistance to flow and th...

  8. Laboratory feasibility study of fusion vessel inner wall chemical analysis by Laser Induced Breakdown Spectroscopy

    International Nuclear Information System (INIS)

    Almaviva, Salvatore; Caneve, Luisa; Colao, Francesco; Fantoni, Roberta; Maddaluno, Giorgio

    2012-01-01

    Graphical abstract: Laser-Induced-Breakdown-Spectroscopy was used for the determination of the atomic composition of multilayered samples simulating the tiles of plasma facing components in the next generation fusion machines. Highlights: ► Description and characterization of an LIBS set-up for diagnostics in fusion machines. ► Identification of atomic composition of multilayered tiles simulating plasma facing components. ► Qualitative applicability of the Calibration Free method for quantitative analysis. ► Feasibility of large scale application in the processes of control during the tiles fabrication. ► Feasibility of erosion monitoring during operation of fusion machines. - Abstract: Laser Induced Breakdown Spectroscopy (LIBS) is nowadays a well established tool for qualitative, semi-quantitative and quantitative analyses of surfaces, with micro-destructive characteristics and capabilities for stratigraphy. LIBS is an appealing technique compared with many other types of elemental analysis thanks to the set up versatility facilitating non-invasive and remote analyses, as well as suitability to diagnostics in harsh environments. In this work, LIBS capabilities were used for the determination of the atomic composition of multilayered samples simulating the tiles of plasma facing components in the next generation fusion machines such as ITER. A new experimental setup was designed and realized in order to optimize the characteristics of an LIBS system working at low pressure and remotely, as it should be for an in situ system to be applied in monitoring the erosion and redeposition phenomena occurring on the inner walls of a fusion device. The effects of time delay and laser fluence on LIBS sensitivity at reduced pressure were examined, looking for operational conditions suitable to analytical applications. The quantitative analysis of some atomic species in the superficial layer has been carried out using a Calibration Free (CF) approach in the time

  9. Non-gated vessel wall imaging of the internal carotid artery using radial scanning and fast spin echo sequence. Evaluation of vessel signal intensity by flow rate at 3.0 tesla

    International Nuclear Information System (INIS)

    Nakamura, Manami; Makabe, Takeshi; Ichikawa, Masaki; Hatakeyama, Ryohei; Sugimori, Hiroyuki; Sakata, Motomichi

    2013-01-01

    Vessel wall imaging using radial scanning does not use a blood flow suppression pulse with gated acquisition. It has been proposed that there may not be a flow void effect if the flow rate is slow; however, this has yet to be empirically tested. To clarify the relationship between the signal intensity of the vessel lumen and the blood flow rate in a flow phantom, we investigated the usefulness of vessel wall imaging at 3.0 tesla (T). We measured the signal intensity while changing the flow rate in the flow phantom. Radial scanning at 1.5 T showed sufficient flow voids at above medium flow rates. There was no significant difference in lumen signal intensity at the carotid artery flow rate. The signal intensity of the vessel lumen decreased sufficiently using the radial scan method at 3.0 T. We thus obtained sufficient flow void effects at the carotid artery flow rate. We conclude this technique to be useful for evaluating plaque if high contrast can be maintained for fixed tissue (such as plaque) and the vessel lumen. (author)

  10. Experimental Study of Pressure Drop and Wall Shear Stress Characteristics of γ /Al2O3-Water Nanofluid in a Circular pipe under Turbulent flow induced vibration.

    Directory of Open Access Journals (Sweden)

    Adil Abbas AL-Moosawy

    2016-09-01

    Full Text Available Experimental study of γ /Al2O3 with mean diameter of less than 50 nm was dispersed in the distilled water that flows through a pipe consist of five sections as work station ,four sections made of carbon steel metal and one sections made of Pyrex glass pipe, with five nanoparticles volume concentrations of 0%,0.1%,0.2%,0.3%,and 0.4% with seven different volume flow rates 100, 200 , 300, 400, 500, 600 ,and 700ℓ/min were investigated to calculated pressure distribution for the cases without rubber ,with 3mm rubber and with 6mm rubber used to support the pipe. Reynolds number was between 20000 and 130000. Frequency value through pipe was measured for all stations of pipe for all cases. The results show that the pressure drop and wall shear stress of the nanofluid increase by increasing the nanoparticles volume concentrations or Reynolds number, the values of frequency through the pipe increase continuously when wall shear stress increases and the ratio of increment increases as nanofluid concentrations increase. Increasing of vibration frequency lead to increasing the friction factor between the pipe and the wall and thus increasing in pressure drop. Several equations between the wall shear stress and frequency for all volume concentration and for three cases without rubber, with rubber has 3mm thickness ,and with rubber has 6mm thickness. Finally, the results led to that γ /Al2O3 could function as a good and alternative conventional working fluid in heat transfer applications. A good agreement is seen between the experimental and those available in the literature

  11. Seismic fragility of RC shear walls in nuclear power plant Part 1: Characterization of uncertainty in concrete constitutive model

    International Nuclear Information System (INIS)

    Syed, Sammiuddin; Gupta, Abhinav

    2015-01-01

    hence its direct use in a simulation based fragility assessment is addressed. A methodology to overcome these limitations by combining the damage plasticity based constitutive model with some existing closed-form expressions is presented in this study. A simulation-based fragility evaluation framework that incorporates the damage plasticity model and the closed-form expressions for evaluating damage variables and application of this framework to an experimentally tested shear wall is presented in the Part-II companion paper.

  12. Seismic fragility of RC shear walls in nuclear power plant Part 1: Characterization of uncertainty in concrete constitutive model

    Energy Technology Data Exchange (ETDEWEB)

    Syed, Sammiuddin [Department of Civil, Construction, and Environmental Engineering, North Carolina State University, 426 Mann Hall, Campus Box 7908, Raleigh, NC 27695-7908 (United States); Gupta, Abhinav, E-mail: agupta1@ncsu.edu [Department of Civil, Construction, and Environmental Engineering, North Carolina State University, 413 Mann Hall, Campus Box 7908, Raleigh, NC 27695-7908 (United States)

    2015-12-15

    hence its direct use in a simulation based fragility assessment is addressed. A methodology to overcome these limitations by combining the damage plasticity based constitutive model with some existing closed-form expressions is presented in this study. A simulation-based fragility evaluation framework that incorporates the damage plasticity model and the closed-form expressions for evaluating damage variables and application of this framework to an experimentally tested shear wall is presented in the Part-II companion paper.

  13. Neutron fluence at the reactor pressure vessel wall - a comparison of French and German procedures and strategies in PWRs

    International Nuclear Information System (INIS)

    Tricot, N.; Jendrich, U.

    2003-01-01

    While the neutrons within the core may take part in the chain reaction, those neutrons emitted from the core are basically lost for the energy production. This 'neutron leakage' represents a loss of fuel efficiency and causes neutron embrittlement of the reactor pressure vessel (RPV) wall. The latter raises safety concerns, needs to be monitored closely and may necessitate mitigating measures. There are different strategies to deal with these two undesirable effects: The neutron emission may be reduced to some extent all around the core or just at the 'hot spots' of RPV embrittlement by tailored core loading patterns. A higher absorption rate of neutrons may also be achieved by a larger water gap between the core and the RPV. In this paper the inter-relations between the distribution of neutron flux, core geometry, core loading strategy, RPV embrittlement and its surveillance are discussed at first. Then the different strategies followed by the German and French operators are described. Finally the conclusions will highlight the communalities and differences between these strategies as different approaches to the same problem of safety as well as economy. (authors)

  14. Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors

    Directory of Open Access Journals (Sweden)

    Tyler DiStefano

    2018-01-01

    Full Text Available Pluripotent stem cells can be differentiated into 3D retinal organoids, with major cell types self-patterning into a polarized, laminated architecture. In static cultures, organoid development may be hindered by limitations in diffusion of oxygen and nutrients. Herein, we report a bioprocess using rotating-wall vessel (RWV bioreactors to culture retinal organoids derived from mouse pluripotent stem cells. Organoids in RWV demonstrate enhanced proliferation, with well-defined morphology and improved differentiation of neurons including ganglion cells and S-cone photoreceptors. Furthermore, RWV organoids at day 25 (D25 reveal similar maturation and transcriptome profile as those at D32 in static culture, closely recapitulating spatiotemporal development of postnatal day 6 mouse retina in vivo. Interestingly, however, retinal organoids do not differentiate further under any in vitro condition tested here, suggesting additional requirements for functional maturation. Our studies demonstrate that bioreactors can accelerate and improve organoid growth and differentiation for modeling retinal disease and evaluation of therapies.

  15. CFD simulation of estimating critical shear stress for cleaning flat ...

    Indian Academy of Sciences (India)

    Sumit Kawale

    2017-11-22

    Nov 22, 2017 ... Jet impingement; wall shear stress; cleaning of flat plate; turbulence model; critical shear stress; ... On comparing the theoretical predictions with wall shear ... distance and Reynolds number on peak value of local shear stress ...

  16. Experimental and CFD Simulation Studies of Wall Shear Stress for Different Impeller Configurations and MBR Activated Sludge

    DEFF Research Database (Denmark)

    Ratkovich, Nicolas Rios; Chan, C.C.V.; Bentzen, Thomas Ruby

    2012-01-01

    in an MBR. Nevertheless, proper experimental validation is required to validate CFD simulation. In this work experimental measurements of shear stress induced by impellers at a membrane surface were made with an electrochemical approach and the results were used to validate CFD simulations. As good results...... appealing for full-scale applications. It has been widely demonstrated that the filtration performances in MBRs can be improved by understanding the shear stress over the membrane surface. Modern tools such as Computational Fluid Dynamics (CFD) can be used to diagnose and understand the shear stress...

  17. Thermodynamic Alloy Design of High Strength and Toughness in 300 mm Thick Pressure Vessel Wall of 1.25Cr-0.5Mo Steel

    Directory of Open Access Journals (Sweden)

    Hye-sung Na

    2018-01-01

    Full Text Available In the 21st century, there is an increasing need for high-capacity, high-efficiency, and environmentally friendly power generation systems. The environmentally friendly integrated gasification combined-cycle (IGCC technology has received particular attention. IGCC pressure vessels require a high-temperature strength and creep strength exceeding those of existing pressure vessels because the operating temperature of the reactor is increased for improved capacity and efficiency. Therefore, high-pressure vessels with thicker walls than those in existing pressure vessels (≤200 mm must be designed. The primary focus of this research is the development of an IGCC pressure vessel with a fully bainitic structure in the middle portion of the 300 mm thick Cr-Mo steel walls. For this purpose, the effects of the alloy content and cooling rates on the ferrite precipitation and phase transformation behaviors were investigated using JMatPro modeling and thermodynamic calculation; the results were then optimized. Candidate alloys from the simulated results were tested experimentally.

  18. Structural Properties of EB-Welded AlSi10Mg Thin-Walled Pressure Vessels Produced by AM-SLM Technology

    Science.gov (United States)

    Nahmany, Moshe; Stern, Adin; Aghion, Eli; Frage, Nachum

    2017-10-01

    Additive manufacturing of metals by selective laser melting (AM-SLM) is hampered by significant limitations in product size due to the limited dimensions of printing trays. Electron beam welding (EBW) is a well-established process that results in relatively minor metallurgical modifications in workpieces due to the ability of EBW to pass high-density energy to the related substance. The present study aims to evaluate structural properties of EB-welded AlSi10Mg thin-walled pressure vessels produced from components prepared by SLM technology. Following the EB welding process, leak and burst tests were conducted, as was fractography analysis. The welded vessels showed an acceptable holding pressure of 30 MPa, with a reasonable residual deformation up to 2.3% and a leak rate better than 1 × 10-8 std-cc s-1 helium. The failures that occurred under longitudinal stresses reflected the presence of two weak locations in the vessels, i.e., the welded joint region and the transition zone between the vessel base and wall. Fractographic analysis of the fracture surfaces of broken vessels displayed the ductile mode of the rupture, with dimples of various sizes, depending on the failure location.

  19. Studies of Electrical and Thermal Conductivities of Sheared Multi-Walled Carbon Nanotube with Isotactic Polypropylene Polymer Composites

    Directory of Open Access Journals (Sweden)

    Parvathalu Kalakonda

    2015-01-01

    at higher temperature due to isotropic electrical and thermal contact in both directions. Oriented MWCNT/iPP nanocomposites exhibit higher electrical and thermal conductivities, attributed primarily by orientation of nanotubes due to the shearing fabrication process.

  20. Experimental Studies on the Behavior of a Newly-Developed Type of Self-Insulating Concrete Masonry Shear Wall under in-Plane Cyclic Loading

    Directory of Open Access Journals (Sweden)

    Abu-Bakre Abdelmoneim Elamin Mohamad

    2017-04-01

    Full Text Available This study aimed to investigate the inelastic behavior of a newly-developed type of self-insulating concrete masonry shear wall (SCMSW under in-plane cyclic loading. The new masonry system was made from concrete blocks with special configurations to provide a stronger bond between units than ordinary concrete masonry units. A total of six fully-grouted SCMSWs were prepared with different heights (1.59 to 5.78 m and different vertical steel configurations. The developed masonry walls were tested under in-plane cyclic loading and different constant axial load ratios. In addition, the relationship between the amount of axial loading, the amount of the flexural reinforcement and the wall aspect ratios and the nonlinear hysteretic response of the SCMSW was evaluated. The results showed that the lateral load capacity of SCMSW increases with the amount of applied axial load and the amount of vertical reinforcement. However, the lateral load capacity decreases as the wall aspect ratio increases. The existence of the boundary elements at the SCMSW ends increases the ductility and the lateral load capacity. Generally, the SCMSW exhibited predominantly flexural behavior. These results agreed with those reported in previous research for walls constructed with ordinary units.

  1. Assessing the feasibility of a high-temperature, helium-cooled vacuum vessel and first wall for the Vulcan tokamak conceptual design

    International Nuclear Information System (INIS)

    Barnard, H.S.; Hartwig, Z.S.; Olynyk, G.M.; Payne, J.E.

    2012-01-01

    The Vulcan conceptual design (R = 1.2 m, a = 0.3 m, B 0 = 7 T), a compact, steady-state tokamak for plasma–material interaction (PMI) science, must incorporate a vacuum vessel capable of operating at 1000 K in order to replicate the temperature-dependent physical chemistry that will govern PMI in a reactor. In addition, the Vulcan divertor must be capable of handling steady-state heat fluxes up to 10 MW m −2 so that integrated materials testing can be performed under reactor-relevant conditions. A conceptual design scoping study has been performed to assess the challenges involved in achieving such a configuration. The Vulcan vacuum system comprises an inner, primary vacuum vessel that is thermally and mechanically isolated from the outer, secondary vacuum vessel by a 10 cm vacuum gap. The thermal isolation minimizes heat conduction between the high-temperature helium-cooled primary vessel and the water-cooled secondary vessel. The mechanical isolation allows for thermal expansion and enables vertical removal of the primary vessel for maintenance or replacement. Access to the primary vessel for diagnostics, lower hybrid waveguides, and helium coolant is achieved through ∼1 m long intra-vessel pipes to minimize temperature gradients and is shown to be commensurate with the available port space in Vulcan. The isolated primary vacuum vessel is shown to be mechanically feasible and robust to plasma disruptions with analytic calculations and finite element analyses. Heat removal in the first wall and divertor, coupled with the ability to perform in situ maintenance and replacement of divertor components for scientific purposes, is achieved by combining existing helium-cooled techniques with innovative mechanical attachments of plasma facing components, either in plate-type helium-cooled modules or independently bolted, helium-jet impingement-cooled tiles. The vacuum vessel and first wall design enables a wide range of potential PFC materials and configurations to

  2. Differentiation of deep subcortical infarction using high-resolution vessel wall MR imaging of middle cerebral artery

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Yun Jung; Choi, Byung Se; Jung, Cheol Kyu; Yoon, Yeon Hong; Sunwoo, Leonard; Kim, Jae Hyoung; Bae, Hee Joon [Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of)

    2017-11-15

    To evaluate the utility of high-resolution vessel wall imaging (HR-VWI) of middle cerebral artery (MCA), and to compare HR-VWI findings between striatocapsular infarction (SC-I) and lenticulostriate infarction (LS-I). This retrospective study was approved by the Institutional Review Board, and informed consent was waived. From July 2009 to February 2012, 145 consecutive patients with deep subcortical infarctions (SC-I, n = 81; LS-I, n = 64) who underwent HR-VWI were included in this study. The degree of MCA stenosis and the characteristics of MCA plaque (presence, eccentricity, location, extent, T2-high signal intensity [T2-HSI], and plaque enhancement) were analyzed, and compared between SC-I and LS-I, using Fisher's exact test. Stenosis was more severe in SC-I than in LS-I (p = 0.040). MCA plaque was more frequent in SC-I than in LS-I (p = 0.028), having larger plaque extent (p = 0.001), more T2-HSI (p = 0.001), and more plaque enhancement (p = 0.002). The eccentricity and location of the plaque showed no significant difference between the two groups.Both SC-I and LS-I have similar HR-VWI findings of the MCA plaque, but SC-I had more frequent, larger plaques with greater T2-HSI and enhancement. This suggests that HR-VWI may have a promising role in assisting the differentiation of underlying pathophysiological mechanism between SC-I and LS-I.

  3. Follow-up Study of ITER Safety Analysis : Large In-vessel First Wall Pipe Break with Wet Confinement Bypass

    Energy Technology Data Exchange (ETDEWEB)

    Moon, Sung Bo; Bang, In Cheol [Ulsan National Institute of Science and Technology, Ulsan (Korea, Republic of)

    2014-10-15

    Previous researches have been analyzed risk assessments of fusion reactors that are dangerous in the severe accidents where the radioactive material released from confinement building to the environment. To simulate the severe accidents in ITER, a number of thermal hydraulics simulation codes were used. Before construction of the fusion reactor, to obtain ITER license about safety issue, MELCOR is chosen as one of the several codes to be used to perform ITER safety analyses. Qualification of the simulation code is to simulate the cooling system in ITER, the transport of radionuclides during design basis accidents (DBAs) including beyond design basis accidents (BDBAs). MELCOR is fully integrated code that models the accidents in Light Water Reactor (LWR). To analyze the accidents in ITER, MELCOR 1.8.2 version is modified. In the nuclear fusion system, the amount of released radioactive material is criteria for safety permission. Tritium (or tritiated water: HTO) and radioactive dust aerosol are the source of radioactive leakage. In the Generic Site Safety Report (GSSR) for the ITER plant, Table I lists the release guidelines for tritium and activation products for normal operation, incidents and accidents. Several accident analyses have been studied to know how much radioactive material could be released from the severe accidents. In the present work, The MELCOR input deck of large First Wall (FW) coolant leak (pipe break) is used to study and radioactive material leakage thorough bypass accident are studied to follow up the ITER safety analysis. In this research, follow-up study of the in-vessel inboard/inboard-outboard FW pipe break was analyzed to investigate the amount of leakage of radioactive aerosol. All of the accident cases released the lower amount of radioactive aerosol compared to the IAEA guide lines. In addition, the OBB pipe break made lower HTO aerosol leakage because of condensation of HTO and adsorption between coolant and aerosol.

  4. Fatigue life assessment of thin-walled welded joints under non-proportional load-time histories by the shear stress rate integral approach

    Directory of Open Access Journals (Sweden)

    A. Bolchoun

    2016-10-01

    Full Text Available Fatigue life tests under constant and variable amplitude loadings were performed on the tube-tube thin-walled welded specimens made of magnesium (AZ31 and AZ61 alloys. The tests included pure axial, pure torsional and combined in-phase and out-of-phase loadings with the load ratio  RR " ", " " 1  . For the tests with variable amplitude loads a Gaußdistributed loading spectrum with S L 4 5 10  cycles was used. Since magnesium welds show a fatigue life reduction under out-of-phase loads, a stress-based method, which takes this behavior into account, is proposed. The out-of-phase loading results in rotating shear stress vectors in the section planes, which are not orthogonal to the surface. This fact is used in order to provide an out-of-phase measure of the load. This measure is computed as an area covered by the shear stress vectors in all planes over a certain time interval, its computation involves the shear stress and the shear stress rate vectors in the individual planes. Fatigue life evaluation for the variable amplitudes loadings is performed using the Palmgren-Miner linear damage accumulation, whereas the total damage of every cycle is split up into two components: the amplitude component and the out-of-phase component. In order to compute the two components a modification of the rainflow counting method, which keeps track of the time intervals, where the cycles occur, must be used. The proposed method also takes into account different slopes of the pure axial and the pure torsional Wöhler-line by means of a Wöhler-line interpolation for combined loadings

  5. Heat-Induced, Pressure-Induced and Centrifugal-Force-Induced Exact Axisymmetric Thermo-Mechanical Analyses in a Thick-Walled Spherical Vessel, an Infinite Cylindrical Vessel, and a Uniform Disk Made of an Isotropic and Homogeneous Material

    Directory of Open Access Journals (Sweden)

    Vebil Yıldırım

    2017-07-01

    Full Text Available Heat-induced, pressure-induced, and centrifugal force-induced axisymmetric exact deformation and stresses in a thick-walled spherical vessel, a cylindrical vessel, and a uniform disk are all determined analytically at a specified constant surface temperature and at a constant angular velocity. The inner and outer pressures are both included in the formulation of annular structures made of an isotropic and homogeneous linear elastic material. Governing equations in the form of Euler-Cauchy differential equation with constant coefficients are solved and results are presented in compact forms. For disks, three different boundary conditions are taken into account to consider mechanical engineering applications. The present study is also peppered with numerical results in graphical forms.

  6. Experimental assessment and numerical modeling of the nonlinear behavior of the masonry shear walls under in-plane cyclic loading considering the brickwork-setting effect

    Directory of Open Access Journals (Sweden)

    Amir Hossein Karimi

    2017-08-01

    Full Text Available In this article, the main purpose is nonlinear analysis of the cyclic behavior of the masonry shear walls including brickwork setting using finite element method. Three different brickwork-settings including running bond style, herringbone style and Zarbi style (herreh style were investigated. To this end, the walls (in dimension of 195×1500×1720 mm were tested in the laboratory and then were simulated using macro modeling method by Abaqus software, and their hysteretic curves was drawn. The concrete damaged plasticity criteria in the Abaqus software is a model used in this research.In this method, the main failure mechanisms of fracture are cracking in tension and crushing in compression. The macro modeling method was used for numerical assessment of the masonry walls. After numerical modeling and drawing hysteretic curves and contrasting them with laboratory results, it was proven that the concrete damaged plasticity model, which is behavioral model for simulating concrete material, can be used for modeling masonry materials under seismic loading. However, this model cannot be used to simulate pinching effect in hysteretic curve drawn from seismic loading. The envelope curve resulted from the numerical analysis of all three brickwork layouts had a good agreement with the results of the laboratory tests, but in Hysteretic curve of Herringbone style and Zarbi style the pinching effect did not match experimental results

  7. Dilated thin-walled blood and lymphatic vessels in human endometrium: a potential role for VEGF-D in progestin-induced break-through bleeding.

    Directory of Open Access Journals (Sweden)

    Jacqueline F Donoghue

    Full Text Available Progestins provide safe, effective and cheap options for contraception as well as the treatment of a variety of gynaecological disorders. Episodes of irregular endometrial bleeding or breakthrough bleeding (BTB are a major unwanted side effect of progestin treatment, such that BTB is the leading cause for discontinued use of an otherwise effective and popular medication. The cellular mechanisms leading to BTB are poorly understood. In this study, we make the novel finding that the large, dilated, thin walled vessels characteristic of human progestin-treated endometrium include both blood and lymphatic vessels. Increased blood and lymphatic vessel diameter are features of VEGF-D action in other tissues and we show by immunolocalisation and Western blotting that stromal cell decidualisation results in a significant increase in VEGF-D protein production, particularly of the proteolytically processed 21 kD form. Using a NOD/scid mouse model with xenografted human endometrium we were able to show that progestin treatment causes decidualisation, VEGF-D production and endometrial vessel dilation. Our results lead to a novel hypothesis to explain BTB, with stromal cell decidualisation rather than progestin treatment per se being the proposed causative event, and VEGF-D being the proposed effector agent.

  8. Development of an application-oriented multi-frequency eddy current procedure for the outer reactor vessel- and store vessel wall of the SNR-300

    International Nuclear Information System (INIS)

    Hoeft, E.

    1991-08-01

    The following companies participated in the development of the application oriented multi-frequency eddy current procedure for the outer reactor vessel- and store vesselwall of the SNR-300: Interatom GmbH (coordinator), MAN-Energie GmbH (ME, subcontractor), Fraunhofer Institut IzfP, own promotion project). The precisely defined work packages of the participating companies Interatom and IzfP were supported by the Federal Minister for Research and Technology in separate promotion project. The present report comprises the work performed at Interatom and ME for developing the manipulator and the subsystems. The development aim was reached largely. Manufactoring of the manipulator with all necessary peripherical equipments was finished and accepted in partial function tests at the manufacturer. Tests at the Interatom teststand however with the fully mounted systems at ambient- and reactor temperature could not be done within the appropriated timeschedule and finance frame. (orig.) [de

  9. High-resolution 3D coronary vessel wall imaging with near 100% respiratory efficiency using epicardial fat tracking: reproducibility and comparison with standard methods.

    Science.gov (United States)

    Scott, Andrew D; Keegan, Jennifer; Firmin, David N

    2011-01-01

    To quantitatively assess the performance and reproducibility of 3D spiral coronary artery wall imaging with beat-to-beat respiratory-motion-correction (B2B-RMC) compared to navigator gated 2D spiral and turbo-spin-echo (TSE) acquisitions. High-resolution (0.7 × 0.7 mm) cross-sectional right coronary wall acquisitions were performed in 10 subjects using four techniques (B2B-RMC 3D spiral with alternate (2RR) and single (1RR) R-wave gating, navigator-gated 2D spiral (2RR) and navigator-gated 2D TSE (2RR)) on two occasions. Wall thickness measurements were compared with repeated measures analysis of variance (ANOVA). Reproducibility was assessed with the intraclass correlation coefficient (ICC). In all, 91% (73/80) of acquisitions were successful (failures: four TSE, two 3D spiral (1RR) and one 3D spiral (2RR)). Respiratory efficiency of the B2B-RMC was less variable and substantially higher than for navigator gating (99.6 ± 1.2% vs. 39.0 ± 7.5%, P B2B-RMC permits coronary vessel wall assessment over multiple thin contiguous slices in a clinically feasible duration. Excellent reproducibility of the technique potentially enables studies of disease progression/regression. Copyright © 2010 Wiley-Liss, Inc.

  10. An objective method to optimize the MR sequence set for plaque classification in carotid vessel wall images using automated image segmentation.

    Directory of Open Access Journals (Sweden)

    Ronald van 't Klooster

    Full Text Available A typical MR imaging protocol to study the status of atherosclerosis in the carotid artery consists of the application of multiple MR sequences. Since scanner time is limited, a balance has to be reached between the duration of the applied MR protocol and the quantity and quality of the resulting images which are needed to assess the disease. In this study an objective method to optimize the MR sequence set for classification of soft plaque in vessel wall images of the carotid artery using automated image segmentation was developed. The automated method employs statistical pattern recognition techniques and was developed based on an extensive set of MR contrast weightings and corresponding manual segmentations of the vessel wall and soft plaque components, which were validated by histological sections. Evaluation of the results from nine contrast weightings showed the tradeoff between scan duration and automated image segmentation performance. For our dataset the best segmentation performance was achieved by selecting five contrast weightings. Similar performance was achieved with a set of three contrast weightings, which resulted in a reduction of scan time by more than 60%. The presented approach can help others to optimize MR imaging protocols by investigating the tradeoff between scan duration and automated image segmentation performance possibly leading to shorter scanning times and better image interpretation. This approach can potentially also be applied to other research fields focusing on different diseases and anatomical regions.

  11. Inner and outer coronary vessel wall segmentation from CCTA using an active contour model with machine learning-based 3D voxel context-aware image force

    Science.gov (United States)

    Sivalingam, Udhayaraj; Wels, Michael; Rempfler, Markus; Grosskopf, Stefan; Suehling, Michael; Menze, Bjoern H.

    2016-03-01

    In this paper, we present a fully automated approach to coronary vessel segmentation, which involves calcification or soft plaque delineation in addition to accurate lumen delineation, from 3D Cardiac Computed Tomography Angiography data. Adequately virtualizing the coronary lumen plays a crucial role for simulating blood ow by means of fluid dynamics while additionally identifying the outer vessel wall in the case of arteriosclerosis is a prerequisite for further plaque compartment analysis. Our method is a hybrid approach complementing Active Contour Model-based segmentation with an external image force that relies on a Random Forest Regression model generated off-line. The regression model provides a strong estimate of the distance to the true vessel surface for every surface candidate point taking into account 3D wavelet-encoded contextual image features, which are aligned with the current surface hypothesis. The associated external image force is integrated in the objective function of the active contour model, such that the overall segmentation approach benefits from the advantages associated with snakes and from the ones associated with machine learning-based regression alike. This yields an integrated approach achieving competitive results on a publicly available benchmark data collection (Rotterdam segmentation challenge).

  12. Particle Trajectories in Rotating Wall Cell Culture Devices

    Science.gov (United States)

    Ramachandran N.; Downey, J. P.

    1999-01-01

    Cell cultures are extremely important to the medical community since such cultures provide an opportunity to perform research on human tissue without the concerns inherent in experiments on individual humans. Development of cells in cultures has been found to be greatly influenced by the conditions of the culture. Much work has focused on the effect of the motions of cells in the culture relative to the solution. Recently rotating wall vessels have been used with success in achieving improved cellular cultures. Speculation and limited research have focused on the low shear environment and the ability of rotating vessels to keep cells suspended in solution rather than floating or sedimenting as the primary reasons for the improved cellular cultures using these devices. It is widely believed that the cultures obtained using a rotating wall vessel simulates to some degree the effect of microgravity on cultures. It has also been speculated that the microgravity environment may provide the ideal acceleration environment for culturing of cellular tissues due to the nearly negligible levels of sedimentation and shear possible. This work predicts particle trajectories of cells in rotating wall vessels of cylindrical and annular design consistent with the estimated properties of typical cellular cultures. Estimates of the shear encountered by cells in solution and the interactions with walls are studied. Comparisons of potential experiments in ground and microgravity environments are performed.

  13. Vascular wall-resident CD44+ multipotent stem cells give rise to pericytes and smooth muscle cells and contribute to new vessel maturation.

    Directory of Open Access Journals (Sweden)

    Diana Klein

    Full Text Available Here, we identify CD44(+CD90(+CD73(+CD34(-CD45(- cells within the adult human arterial adventitia with properties of multipotency which were named vascular wall-resident multipotent stem cells (VW-MPSCs. VW-MPSCs exhibit typical mesenchymal stem cell characteristics including cell surface markers in immunostaining and flow cytometric analyses, and differentiation into adipocytes, chondrocytes and osteocytes under culture conditions. Particularly, TGFß1 stimulation up-regulates smooth muscle cell markers in VW-MPSCs. Using fluorescent cell labelling and co-localisation studies we show that VW-MPSCs differentiate to pericytes/smooth muscle cells which cover the wall of newly formed endothelial capillary-like structures in vitro. Co-implantation of EGFP-labelled VW-MPSCs and human umbilical vein endothelial cells into SCID mice subcutaneously via Matrigel results in new vessels formation which were covered by pericyte- or smooth muscle-like cells generated from implanted VW-MPSCs. Our results suggest that VW-MPSCs are of relevance for vascular morphogenesis, repair and self-renewal of vascular wall cells and for local capacity of neovascularization in disease processes.

  14. Effects of Simulated Microgravity on Otolith Growth of Larval Zebrafish using a Rotating-Wall Vessel: Appropriate Rotation Speed and Fish Developmental Stage

    Science.gov (United States)

    Li, Xiaoyan; Anken, Ralf; Liu, Liyue; Wang, Gaohong; Liu, Yongding

    2017-02-01

    Stimulus dependence is a general feature of developing animal sensory systems. In this respect, it has extensively been shown earlier that fish inner ear otoliths can act as test masses as their growth is strongly affected by altered gravity such as hypergravity obtained using centrifuges, by (real) microgravity achieved during spaceflight or by simulated microgravity using a ground-based facility. Since flight opportunities are scarce, ground-based simulators of microgravity, using a wide variety of physical principles, have been developed to overcome this shortcoming. Not all of them, however, are equally well suited to provide functional weightlessness from the perspective of the biosystem under evaluation. Therefore, the range of applicability of a particular simulator has to be extensively tested. Earlier, we have shown that a Rotating-Wall Vessel (RWV) can be used to provide simulated microgravity for developing Zebrafish regarding the effect of rotation on otolith development. In the present study, we wanted to find the most effective speed of rotation and identify the appropriate developmental stage of Zebrafish, where effects are the largest, in order to provide a methodological basis for future in-depth analyses dedicated to the physiological processes underlying otolith growth at altered gravity. Last not least, we compared data on the effect of simulated microgravity on the size versus the weight of otoliths, since the size usually is measured in related studies due to convenience, but the weight more accurately approximates the physical capacity of an otolith. Maintaining embryos at 10 hours post fertilization for three days in the RWV, we found that 15 revolutions per minute (rpm) yielded the strongest effects on otolith growth. Maintenance of Zebrafish staged at 10 hpf, 1 day post fertilization (dpf), 4 dpf, 7 dpf and 14 dpf for three days at 15 rpm resulted in the most prominent effects in 7 dpf larvae. Weighing versus measuring the size of otoliths

  15. Formation of three-dimensional cell/polymer constructs for bone tissue engineering in a spinner flask and a rotating wall vessel bioreactor

    Science.gov (United States)

    Sikavitsas, Vassilios I.; Bancroft, Gregory N.; Mikos, Antonios G.; McIntire, L. V. (Principal Investigator)

    2002-01-01

    The aim of this study is to investigate the effect of the cell culture conditions of three-dimensional polymer scaffolds seeded with rat marrow stromal cells (MSCs) cultured in different bioreactors concerning the ability of these cells to proliferate, differentiate towards the osteoblastic lineage, and generate mineralized extracellular matrix. MSCs harvested from male Sprague-Dawley rats were culture expanded, seeded on three-dimensional porous 75:25 poly(D,L-lactic-co-glycolic acid) biodegradable scaffolds, and cultured for 21 days under static conditions or in two model bioreactors (a spinner flask and a rotating wall vessel) that enhance mixing of the media and provide better nutrient transport to the seeded cells. The spinner flask culture demonstrated a 60% enhanced proliferation at the end of the first week when compared to static culture. On day 14, all cell/polymer constructs exhibited their maximum alkaline phosphatase activity (AP). Cell/polymer constructs cultured in the spinner flask had 2.4 times higher AP activity than constructs cultured under static conditions on day 14. The total osteocalcin (OC) secretion in the spinner flask culture was 3.5 times higher than the static culture, with a peak OC secretion occurring on day 18. No considerable AP activity and OC secretion were detected in the rotating wall vessel culture throughout the 21-day culture period. The spinner flask culture had the highest calcium content at day 14. On day 21, the calcium deposition in the spinner flask culture was 6.6 times higher than the static cultured constructs and over 30 times higher than the rotating wall vessel culture. Histological sections showed concentration of cells and mineralization at the exterior of the foams at day 21. This phenomenon may arise from the potential existence of nutrient concentration gradients at the interior of the scaffolds. The better mixing provided in the spinner flask, external to the outer surface of the scaffolds, may explain the

  16. Morphological changes of cerebral vessels and expression patterns of MMP-2 and MMP-9 on cerebrovascular wall of alcoholic rats.

    Science.gov (United States)

    Qi, Qian; Liu, Xia; Zhang, Guozhong; He, Wenjing; Ma, Rufei; Cong, Bin; Li, Yingmin

    2014-01-01

    Alcohol abuse increases the incidence of cerebral accidents, which correlates with cerebrovascular structural changes. The present study was designed to observe the cerebrovascular remodeling of drinking rats with light microscopy and transmission electron microscopy (TEM). Short-term alcohol administration induced apparent amplification of perivascular spaces around small vessels in brain tissue, while long-term administration caused pathological changes of basilar arteries (BAs), including endothelial exfoliation, inner elastic lamina (IEL) fragmentation and thickening of tunica media and adventitia. In addition, the relationship between cerebrovascular remodeling and MMP-2 and MMP-9 synthesized by endothelial cells and vascular smooth muscle cells was explored by immunohistochemistry. The two protein expression in cerebral vessels changed dynamically, peaking at 1-2 weeks after treatment, and decreasing as treatment continued. These results suggest that MMP-2 and MMP-9 may play a significant role in blood-brain barrier disruption after alcohol abuse. But the chronic changes of cerebral arteries resulted from drinking are not coincident with time course of MMP-2 and MMP-9 expression in situ.

  17. In-vessel calibration of the imaging diagnostics for the real-time protection of the JET ITER-like wall

    Energy Technology Data Exchange (ETDEWEB)

    Huber, V., E-mail: V.Huber@fz-juelich.de [Forschungszentrum Jülich GmbH, Supercomputing Centre, 52425 Jülich (Germany); Huber, A.; Mertens, Ph.; Sergienko, G. [Forschungszentrum Jülich GmbH, Institut für Energie- und Klimaforschung—Plasmaphysik, Partner of the Trilateral Euregio Cluster (TEC), 52425 Jülich (Germany); Kinna, D.; Balboa, I.; Collins, S.; Conway, N.; Maggi, C. F.; Matthews, G. F.; Meigs, A. G.; Price, M.; Silburn, S.; Zastrow, K.-D. [CCFE, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Drewelow, P. [MPI für Plasmaphysik, Greifswald (Germany); Wynn, A. [York Plasma Institute, University of York, Heslington, York YO10 5DD (United Kingdom)

    2016-11-15

    The in situ absolute calibration of the JET real-time protection imaging system has been performed for the first time by means of radiometric light source placed inside the JET vessel and operated by remote handling. High accuracy of the calibration is confirmed by cross-validation of the near infrared (NIR) cameras against each other, with thermal IR cameras, and with the beryllium evaporator, which lead to successful protection of the JET first wall during the last campaign. The operation temperature ranges of NIR protection cameras for the materials used on JET are Be 650-1600 °C, W coating 600-1320 °C, and W 650-1500 °C.

  18. Steel plates and concrete filled composite shear walls related nuclear structural engineering: Experimental study for out-of-plane cyclic loading

    Energy Technology Data Exchange (ETDEWEB)

    Li, Xiaohu [The College of Architecture and Civil Engineering, Beijing University of Technology, Beijing 100124 (China); Li, Xiaojun, E-mail: beerli@vip.sina.com [The College of Architecture and Civil Engineering, Beijing University of Technology, Beijing 100124 (China); Institute of Geophysics, China Earthquake Administration, Beijing 100081 (China)

    2017-04-15

    Based on the program of CAP1400 nuclear structural engineering, the out-of-plane seismic behavior of steel plate and concrete infill composite shear walls (SCW) was investigated. 6 1/5 scaled specimens were conducted which consist of 5 SCW specimens and 1 reinforced concrete (RC) specimen. The specimens were tested under out-of-plane cyclic loading. The effect of the thickness of steel plate, vertical load and the strength grade of concrete on the out-of-plane seismic behavior of SCW were analyzed. The results show that the thickness of steel plate and vertical load have great influence on the ultimate bearing capacity and lateral stiffness, however, the influence of the strength grade of concrete was little within a certain range. SCW is presented to have a better ultimate capacity and lateral stiffness but have worse ductility in failure stage than that of RC. Based on the experiment, the cracking load of concrete infill SCW was analyzed in theory. The modified calculation formula of the cracking load was made, the calculated results showed good agreement with the test results. The formula can be used as the practical design for the design of cracking loads.

  19. Thermo-mechanical vibration analysis of a single-walled carbon nanotube embedded in an elastic medium based on higher-order shear deformation beam theory

    International Nuclear Information System (INIS)

    Ebrahimi, Farzad; Salari, Erfan

    2015-01-01

    In this study, the thermal effect on the free vibration characteristics of embedded Single-walled carbon nanotubes (SWCNTs) based on the size-dependent Reddy higher order shear deformation beam theory subjected to in-plane thermal loading is investigated by presenting a Navier-type solution and employing a semi-analytical Differential transform method (DTM) for the first time. In addition, the exact nonlocal Reddy beam theory solution presented here should be useful to engineers designing nanoelectromechanical devices. The small scale effect is considered based on nonlocal elasticity theory of Eringen. The nonlocal equations of motion are derived through Hamilton's principle, and they are solved by applying DTM. Numerical results reveal that the proposed modeling and semi-analytical approach can provide more accurate frequency results of the SWCNTs compared to analytical results and some cases in the literature. The detailed mathematical derivations are presented, and numerical investigations are performed, whereas emphasis is placed on investigating the effect of several parameters such as small-scale effects, boundary conditions, mode number, thickness ratio, temperature change, and Winkler spring modulus on the natural frequencies of the SWCNTs in detail. The vibration behavior of SWCNTs is significantly influenced by these effects. Results indicate that the inclusion of size effect results in a decrease in nanobeam stiffness and leads to a decrease in natural frequency. Numerical results are presented to serve as benchmarks for future analyses of SWCNTs.

  20. Seismic Retrofitting: Reinforced Concrete (RC shear wall versus Reinforcement of RC element by Carbon Fiber Reinforced Polymer (CFRP using PUSHOVER analysis

    Directory of Open Access Journals (Sweden)

    Yahya RIYAD

    2016-12-01

    Full Text Available Seismic retrofitting of constructions vulnerable to earthquakes is a current problem of great political and social relevance. During the last sixty years, moderate to severe earthquakes have occurred in Morocco (specifically in Agadir 1960 and Hoceima 2004. Such events have clearly shown the vulnerability of the building stock in particular and of the built environment in general. Hence, it is very much essential to retrofit the vulnerable building to cope up for the next damaging earthquake. In this paper, the focus will be on a comparative study between two techniques of seismic retrofitting, the first one is a reinforcement using carbon fiber reinforced polymer (CFRP applied to RC elements by bonding , and the second one is a reinforcement with a shear wall. For this study, we will use a non-linear static analysis -also known as Pushover analysis - on a reinforced concrete structure consisting of beams and columns, and composed from eight storey with a gross area of 240 m², designed conforming to the Moroccan Seismic code[1].

  1. Steel plates and concrete filled composite shear walls related nuclear structural engineering: Experimental study for out-of-plane cyclic loading

    International Nuclear Information System (INIS)

    Li, Xiaohu; Li, Xiaojun

    2017-01-01

    Based on the program of CAP1400 nuclear structural engineering, the out-of-plane seismic behavior of steel plate and concrete infill composite shear walls (SCW) was investigated. 6 1/5 scaled specimens were conducted which consist of 5 SCW specimens and 1 reinforced concrete (RC) specimen. The specimens were tested under out-of-plane cyclic loading. The effect of the thickness of steel plate, vertical load and the strength grade of concrete on the out-of-plane seismic behavior of SCW were analyzed. The results show that the thickness of steel plate and vertical load have great influence on the ultimate bearing capacity and lateral stiffness, however, the influence of the strength grade of concrete was little within a certain range. SCW is presented to have a better ultimate capacity and lateral stiffness but have worse ductility in failure stage than that of RC. Based on the experiment, the cracking load of concrete infill SCW was analyzed in theory. The modified calculation formula of the cracking load was made, the calculated results showed good agreement with the test results. The formula can be used as the practical design for the design of cracking loads.

  2. A patient-specific virtual stenotic model of the coronary artery to analyze the relationship between fractional flow reserve and wall shear stress.

    Science.gov (United States)

    Lee, Kyung Eun; Kim, Gook Tae; Lee, Jeong Sang; Chung, Ju-Hyun; Shin, Eun-Seok; Shim, Eun Bo

    2016-11-01

    As the stenotic severity of a patient increases, fractional flow reserve (FFR) decreases, whereas the maximum wall shear stress (WSSmax) increases. However, the way in which these values can change according to stenotic severity has not previously been investigated. The aim of this study is to devise a virtual stenosis model to investigate variations in the coronary hemodynamic parameters of patients according to stenotic severity. To simulate coronary hemodynamics, a three-dimensional (3D) coronary artery model of computational fluid dynamics is coupled with a lumped parameter model of the coronary micro-vasculature and venous system. To validate the present method, we first simulated 13 patient-specific models of the coronary arteries and compared the results with those obtained clinically. Then, virtually narrowed coronary arterial models derived from the patient-specific cases were simulated to obtain the WSSmax and FFR values. The variations in FFR and WSSmax against the percentage of diameter stenosis in clinical cases were reproducible by the virtual stenosis models. We also found that the simulated FFR values were linearly correlated with the WSSmax values, but the linear slope varied by patient. We implemented 130 additional virtual models of stenosed coronary arteries based on data from 13 patients and obtained statistically meaningful results that were identical to the large-scale clinical studies. And the slope of the correlation line between FFR and WSSmax may help clinicians to design treatment plans for patients. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  3. High shear stress relates to intraplaque haemorrhage in asymptomatic carotid plaques

    DEFF Research Database (Denmark)

    Tuenter, A.; Selwaness, M.; Arias Lorza, A.

    2016-01-01

    estimating equations analysis, adjusting for age, sex and carotid wall thickness. RESULTS: The study group consisted of 93 atherosclerotic carotid arteries of 74 participants. In plaques with higher maximum shear stresses, IPH was more often present (OR per unit increase in maximum shear stress (log......BACKGROUND AND AIMS: Carotid artery plaques with vulnerable plaque components are related to a higher risk of cerebrovascular accidents. It is unknown which factors drive vulnerable plaque development. Shear stress, the frictional force of blood at the vessel wall, is known to influence plaque...... formation. We evaluated the association between shear stress and plaque components (intraplaque haemorrhage (IPH), lipid rich necrotic core (LRNC) and/or calcifications) in relatively small carotid artery plaques in asymptomatic persons. METHODS: Participants (n = 74) from the population-based Rotterdam...

  4. Impact of scaffold micro and macro architecture on Schwann cell proliferation under dynamic conditions in a rotating wall vessel bioreactor

    International Nuclear Information System (INIS)

    Valmikinathan, Chandra M.; Hoffman, John; Yu, Xiaojun

    2011-01-01

    Over the last decade tissue engineering has emerged as a powerful alternative to regenerate lost tissues owing to trauma or tumor. Evidence shows that Schwann cell containing scaffolds have improved performance in vivo as compared to scaffolds that depend on cellularization post implantation. However, owing to limited supply of cells from the patients themselves, several approaches have been taken to enhance cell proliferation rates to produce complete and uniform cellularization of scaffolds. The most common approach is the application of a bioreactor to enhance cell proliferation rate and therefore reduce the time needed to obtain sufficiently significant number of glial cells, prior to implantation. In this study, we show the application of a rotating wall bioreactor system for studying Schwann cell proliferation on nanofibrous spiral shaped scaffolds, prepared by solvent casting and salt leaching techniques. The scaffolds were fabricated from polycaprolactone (PCL), which has ideal mechanical properties and upon degradation does not produce acidic byproducts. The spiral scaffolds were coated with aligned or random nanofibers, produced by electrospinning, to provide a substrate that mimics the native extracellular matrix and the essential contact guidance cues. At the 4 day time point, an enhanced rate of cell proliferation was observed on the open structured nanofibrous spiral scaffolds in a rotating wall bioreactor, as compared to static culture conditions. However, the cell proliferation rate on the other contemporary scaffolds architectures such as the tubular and cylindrical scaffolds show reduced cell proliferation in the bioreactor as compared to static conditions, at the same time point. Moreover, the rotating wall bioreactor does not alter the orientation or the phenotype of the Schwann cells on the aligned nanofiber containing scaffolds, wherein, the cells remain aligned along the length of the scaffolds. Therefore, these open structured spiral

  5. Return to normal of sup(99m)Tc-plasmin test after deep venous thrombosis and its relationship to vessel wall fibrinolysis

    Energy Technology Data Exchange (ETDEWEB)

    Edenbrandt, C.M.; Hedner, U.; Tengborn, L.; Nilsson, J.; Ohlin, P.

    1986-08-01

    Fourteen patients with deep venous thrombosis (DVT) and a positive sup(99m)Tc-plasmin test were followed up to determine how soon a negative test was obtained. Localization and extension of the thrombi were determined by phlebography. Plasminogen activator activity in vein walls and local fibrinolytic activity after venous occlusion were measured in order to find out what the prerequisites for impaired thrombolysis are. The time required to obtain a negative sup(99m)Tc-plasmin test showed considerable variation, ranging from less than 1 week to more than 6 months. The sup(99m)Tc-plasmin test had returned to normal in 64% of the patients after 6 months. No relationship was found between vessel wall fibrinolysis and time to normalization. Instead, we found an association between the time to normalization of the sup(99m)Tc-plasmin test and the size of the thrombus, according to phlebography, as well as between the time to normalization of the sup(99m)Tc-plasmin test and the extension of leg points with a positive sup(99m)Tc-plasmin test at admission. The finding of abnormal sup(99m)Tc-plasmin test results more than 6 months after acute DVT is of practical importance and warrants caution when evaluating patients with symptoms and signs suggestive of acute recurrent DVT.

  6. PDX vacuum vessel stress analysis

    International Nuclear Information System (INIS)

    Nikodem, Z.D.

    1975-01-01

    A stress analysis of PDX vacuum vessel is described and the summary of results is presented. The vacuum vessel is treated as a toroidal shell of revolution subjected to an internal vacuum. The critical buckling pressure is calculated. The effects of the geometrical discontinuity at the juncture of toroidal shell head and cylindrical outside wall, and the concavity of the cylindrical wall are examined. An effect of the poloidal field coil supports and the vessel outside supports on the stress distribution in the vacuum vessel is determined. A method evaluating the influence of circular ports in the vessel wall on the stress level in the vessel is outlined

  7. Interaction between a normal shock wave and a turbulent boundary layer at high transonic speeds. Part 1: Pressure distribution. Part 2: Wall shear stress. Part 3: Simplified formulas for the prediction of surface pressures and skin friction

    Science.gov (United States)

    Adamson, T. C., Jr.; Liou, M. S.; Messiter, A. F.

    1980-01-01

    An asymptotic description is derived for the interaction between a shock wave and a turbulent boundary layer in transonic flow, for a particular limiting case. The dimensionless difference between the external flow velocity and critical sound speed is taken to be much smaller than one, but large in comparison with the dimensionless friction velocity. The basic results are derived for a flat plate, and corrections for longitudinal wall curvature and for flow in a circular pipe are also shown. Solutions are given for the wall pressure distribution and the shape of the shock wave. Solutions for the wall shear stress are obtained, and a criterion for incipient separation is derived. Simplified solutions for both the wall pressure and skin friction distributions in the interaction region are given. These results are presented in a form suitable for use in computer programs.

  8. Incremental value of regional wall motion analysis immediately after exercise for the detection of single-vessel coronary artery disease. Study by separate acquisition, dual-isotope ECG-gated single-photon emission computed tomography

    International Nuclear Information System (INIS)

    Yoda, Shunichi; Sato, Yuichi; Matsumoto, Naoya; Tani, Shigemasa; Takayama, Tadateru; Uchiyama, Takahisa; Saito, Satoshi

    2005-01-01

    Although the detection of wall motion abnormalities gives incremental value to myocardial perfusion single-photon emission computed tomography (SPECT) in the diagnosis of extensive coronary artery disease (CAD) and high-grade single-vessel CAD, whether or not it is useful in the diagnosis of mild, single-vessel CAD has not been studied previously. Separate acquisition, dual isotope electrocardiogram (ECG)-gated SPECT was performed in 97 patients with a low likelihood of CAD (Group 1) and 46 patients with single-vessel CAD (Group 2). Mild CAD was defined by stenosis of 50-75% (Group 2a, n=22) and moderate to severe CAD was defined by stenosis ≥76% (Group 2b, n=24). Myocardial perfusion and wall motion were graded by a 5 point-scale, 20-segment model. The sensitivity of myocardial perfusion alone was 50% for Group 2a, 83% for Group 2b and 67% for Group 2 as a whole. The overall specificity was 90%. When the wall motion analysis was combined, the sensitivity was increased to 82% in Group 2a and 92% in Group 2b. The ability to detect a wall motion abnormality immediately after exercise gives incremental diagnostic value to myocardial perfusion SPECT in the identification of mild, single-vessel CAD. (author)

  9. The values of wall shear stress, turbulence kinetic energy and blood pressure gradient are associated with atherosclerotic plaque erosion in rabbits.

    Science.gov (United States)

    Sameshima, Naoki; Yamashita, Atsushi; Sato, Shinya; Matsuda, Shuntaro; Matsuura, Yunosuke; Asada, Yujiro

    2014-01-01

    To clarify the contribution of hemodynamic factors to the onset of plaque erosion in smooth muscle cell (SMC)-rich atherosclerotic plaque. We developed a rabbit model of SMC-rich atherosclerotic plaque with various degree of stenosis induced by incomplete ligation and generated three-dimensional models of five rabbit femoral arteries based on 130-162 serial histological cross-sections at 100-μm intervals per artery. We performed a computational blood flow simulation using the Reynolds-averaged Navier-Stokes model and calculated the wall shear stress (WSS), turbulence kinetic energy (TKE), blood pressure (BP) and blood pressure gradients (BPG) in eight sections (the inlet, the stenotic portion and areas 1, 2 and 5mm from the stenotic portion) in each rabbit. We also investigated whether the magnitude of WSS or TKE was related to the presence or absence of erosive injury by evaluating six points (the locally highest, median and lowest of WSS or TKE) in each section. The magnitudes of WSS, TKE and BPG, but not BP, correlated significantly with the extent of histologically-defined plaque erosion (WSS, r=0.55, p<0.001; TKE, r=0.53, p<0.001; BPG, r=0.61, p<0.0001, n=40). The values for WSS and TKE were significantly larger at sites with, compared to without, erosive injury (n=107 and n=119 points, respectively; both p<0.0001). These results suggest that increased values of WSS, TKE and BPG considerably contribute to the onset of plaque erosion.

  10. Influence of the Accuracy of Angiography-Based Reconstructions on Velocity and Wall Shear Stress Computations in Coronary Bifurcations: A Phantom Study

    Science.gov (United States)

    Schrauwen, Jelle T. C.; Karanasos, Antonios; van Ditzhuijzen, Nienke S.; Aben, Jean-Paul; van der Steen, Antonius F. W.

    2015-01-01

    Introduction Wall shear stress (WSS) plays a key role in the onset and progression of atherosclerosis in human coronary arteries. Especially sites with low and oscillating WSS near bifurcations have a higher propensity to develop atherosclerosis. WSS computations in coronary bifurcations can be performed in angiography-based 3D reconstructions. It is essential to evaluate how reconstruction errors influence WSS computations in mildly-diseased coronary bifurcations. In mildly-diseased lesions WSS could potentially provide more insight in plaque progression. Materials Methods Four Plexiglas phantom models of coronary bifurcations were imaged with bi-plane angiography. The lumens were segmented by two clinically experienced readers. Based on the segmentations 3D models were generated. This resulted in three models per phantom: one gold-standard from the phantom model itself, and one from each reader. Steady-state and transient simulations were performed with computational fluid dynamics to compute the WSS. A similarity index and a noninferiority test were used to compare the WSS in the phantoms and their reconstructions. The margin for this test was based on the resolution constraints of angiography. Results The reconstruction errors were similar to previously reported data; in seven out of eight reconstructions less than 0.10 mm. WSS in the regions proximal and far distal of the stenosis showed a good agreement. However, the low WSS areas directly distal of the stenosis showed some disagreement between the phantoms and the readers. This was due to small deviations in the reconstruction of the stenosis that caused differences in the resulting jet, and consequently the size and location of the low WSS area. Discussion This study showed that WSS can accurately be computed within angiography-based 3D reconstructions of coronary arteries with early stage atherosclerosis. Qualitatively, there was a good agreement between the phantoms and the readers. Quantitatively, the

  11. Influence of the Accuracy of Angiography-Based Reconstructions on Velocity and Wall Shear Stress Computations in Coronary Bifurcations: A Phantom Study.

    Directory of Open Access Journals (Sweden)

    Jelle T C Schrauwen

    Full Text Available Wall shear stress (WSS plays a key role in the onset and progression of atherosclerosis in human coronary arteries. Especially sites with low and oscillating WSS near bifurcations have a higher propensity to develop atherosclerosis. WSS computations in coronary bifurcations can be performed in angiography-based 3D reconstructions. It is essential to evaluate how reconstruction errors influence WSS computations in mildly-diseased coronary bifurcations. In mildly-diseased lesions WSS could potentially provide more insight in plaque progression.Four Plexiglas phantom models of coronary bifurcations were imaged with bi-plane angiography. The lumens were segmented by two clinically experienced readers. Based on the segmentations 3D models were generated. This resulted in three models per phantom: one gold-standard from the phantom model itself, and one from each reader. Steady-state and transient simulations were performed with computational fluid dynamics to compute the WSS. A similarity index and a noninferiority test were used to compare the WSS in the phantoms and their reconstructions. The margin for this test was based on the resolution constraints of angiography.The reconstruction errors were similar to previously reported data; in seven out of eight reconstructions less than 0.10 mm. WSS in the regions proximal and far distal of the stenosis showed a good agreement. However, the low WSS areas directly distal of the stenosis showed some disagreement between the phantoms and the readers. This was due to small deviations in the reconstruction of the stenosis that caused differences in the resulting jet, and consequently the size and location of the low WSS area.This study showed that WSS can accurately be computed within angiography-based 3D reconstructions of coronary arteries with early stage atherosclerosis. Qualitatively, there was a good agreement between the phantoms and the readers. Quantitatively, the low WSS regions directly distal to

  12. Scan-rescan reproducibility of segmental aortic wall shear stress as assessed by phase-specific segmentation with 4D flow MRI in healthy volunteers.

    Science.gov (United States)

    van der Palen, Roel L F; Roest, Arno A W; van den Boogaard, Pieter J; de Roos, Albert; Blom, Nico A; Westenberg, Jos J M

    2018-05-26

    The aim was to investigate scan-rescan reproducibility and observer variability of segmental aortic 3D systolic wall shear stress (WSS) by phase-specific segmentation with 4D flow MRI in healthy volunteers. Ten healthy volunteers (age 26.5 ± 2.6 years) underwent aortic 4D flow MRI twice. Maximum 3D systolic WSS (WSSmax) and mean 3D systolic WSS (WSSmean) for five thoracic aortic segments over five systolic cardiac phases by phase-specific segmentations were calculated. Scan-rescan analysis and observer reproducibility analysis were performed. Scan-rescan data showed overall good reproducibility for WSSmean (coefficient of variation, COV 10-15%) with moderate-to-strong intraclass correlation coefficient (ICC 0.63-0.89). The variability in WSSmax was high (COV 16-31%) with moderate-to-good ICC (0.55-0.79) for different aortic segments. Intra- and interobserver reproducibility was good-to-excellent for regional aortic WSSmax (ICC ≥ 0.78; COV ≤ 17%) and strong-to-excellent for WSSmean (ICC ≥ 0.86; COV ≤ 11%). In general, ascending aortic segments showed more WSSmax/WSSmean variability compared to aortic arch or descending aortic segments for scan-rescan, intraobserver and interobserver comparison. Scan-rescan reproducibility was good for WSSmean and moderate for WSSmax for all thoracic aortic segments over multiple systolic phases in healthy volunteers. Intra/interobserver reproducibility for segmental WSS assessment was good-to-excellent. Variability of WSSmax is higher and should be taken into account in case of individual follow-up or in comparative rest-stress studies to avoid misinterpretation.

  13. Relationship Between Endothelial Wall Shear Stress and High-Risk Atherosclerotic Plaque Characteristics for Identification of Coronary Lesions That Cause Ischemia: A Direct Comparison With Fractional Flow Reserve.

    Science.gov (United States)

    Han, Donghee; Starikov, Anna; Ó Hartaigh, Bríain; Gransar, Heidi; Kolli, Kranthi K; Lee, Ji Hyun; Rizvi, Asim; Baskaran, Lohendran; Schulman-Marcus, Joshua; Lin, Fay Y; Min, James K

    2016-12-19

    Wall shear stress (WSS) is an established predictor of coronary atherosclerosis progression. Prior studies have reported that high WSS has been associated with high-risk atherosclerotic plaque characteristics (APCs). WSS and APCs are quantifiable by coronary computed tomography angiography, but the relationship of coronary lesion ischemia-evaluated by fractional flow reserve-to WSS and APCs has not been examined. WSS measures were obtained from 100 evaluable patients who underwent coronary computed tomography angiography and invasive coronary angiography with fractional flow reserve. Patients were categorized according to tertiles of mean WSS values defined as low, intermediate, and high. Coronary ischemia was defined as fractional flow reserve ≤0.80. Stenosis severity was determined by minimal luminal diameter. APCs were defined as positive remodeling, low attenuation plaque, and spotty calcification. The likelihood of having positive remodeling and low-attenuation plaque was greater in the high WSS group compared with the low WSS group after adjusting for minimal luminal diameter (odds ratio for positive remodeling: 2.54, 95% CI 1.12-5.77; odds ratio for low-attenuation plaque: 2.68, 95% CI 1.02-7.06; both Prelationship was observed between WSS and fractional flow reserve when adjusting for either minimal luminal diameter or APCs. WSS displayed no incremental benefit above stenosis severity and APCs for detecting lesions that caused ischemia (area under the curve for stenosis and APCs: 0.87, 95% CI 0.81-0.93; area under the curve for stenosis, APCs, and WSS: 0.88, 95% CI 0.82-0.93; P=0.30 for difference). High WSS is associated with APCs independent of stenosis severity. WSS provided no added value beyond stenosis severity and APCs for detecting lesions with significant ischemia. © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

  14. Breast arterial calcification and risk of carotid atherosclerosis: Focusing on the preferentially affected layer of the vessel wall

    Energy Technology Data Exchange (ETDEWEB)

    Sedighi, Nahid, E-mail: nsedighi@sina.tums.ac.ir [Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences. North Kargar Ave., Tehran 14114 (Iran, Islamic Republic of); Radmard, Amir Reza, E-mail: radmard@ams.ac.ir [Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences. North Kargar Ave., Tehran 14114 (Iran, Islamic Republic of); Radmehr, Ali, E-mail: radmehr@sina.tums.ac.ir [Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences. North Kargar Ave., Tehran 14114 (Iran, Islamic Republic of); Hashemi, Pari, E-mail: phtums@yahoo.com [Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences. North Kargar Ave., Tehran 14114 (Iran, Islamic Republic of); Hajizadeh, Abdolmahmoud, E-mail: mroomezi@yahoo.com [Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences. North Kargar Ave., Tehran 14114 (Iran, Islamic Republic of); Taheri, Amir Pejman Hashemi, E-mail: hashemip@sina.tums.ac.ir [Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences. North Kargar Ave., Tehran 14114 (Iran, Islamic Republic of)

    2011-08-15

    Objective: To assess the relationship between breast arterial calcification (BAC) detected on screening mammography and atherosclerosis of carotid arteries considering the most likely involved layer of the arterial wall. Materials and methods: A total of 537 consecutive women who underwent screening mammography were enrolled in this study. Seventy-nine subjects having BAC, aged 46-75 years, and 125 age-matched controls from those without BAC were selected for ultrasound examination of carotid arteries assessing intima-media thickness (IMT) and plaque presence. Participants were divided into three groups of risk including, low-risk: IMT < 0.6 mm without plaque, medium-risk: 0.6 mm {<=} IMT {<=} 0.8 mm without plaque and high-risk: IMT > 0.8 mm and/or plaque. Risk factors for atherosclerosis were obtained from medical records for independent effects. Results: BAC was present in 14.7% of mammograms. According to multivariable logistic regression analyses, significant association was identified between the carotid atherosclerosis risk and presence of BAC. Compared to women with IMT < 0.6 mm, those with 0.6 mm {<=} IMT{<=} 0.8 mm and IMT > 0.8 mm had OR (95% CI) of 4.88 (1.47-16.16) and 23.36 (4.54-120.14), respectively. The OR (95% CI) for carotid plaque was 3.13 (1.3-7.57). There was no interaction between IMT category and plaque. Significant associations were also detected with postmenopausal duration (P = 0.02) and hypertension (P = 0.004). Conclusion: The risk of carotid atherosclerosis increases with the presence of BAC. Women with BAC are more likely to have thicker IMT than plaque, which could be attributed to the preferentially similar affected layer of media causing thick IMT rather than plaque.

  15. Breast arterial calcification and risk of carotid atherosclerosis: Focusing on the preferentially affected layer of the vessel wall

    International Nuclear Information System (INIS)

    Sedighi, Nahid; Radmard, Amir Reza; Radmehr, Ali; Hashemi, Pari; Hajizadeh, Abdolmahmoud; Taheri, Amir Pejman Hashemi

    2011-01-01

    Objective: To assess the relationship between breast arterial calcification (BAC) detected on screening mammography and atherosclerosis of carotid arteries considering the most likely involved layer of the arterial wall. Materials and methods: A total of 537 consecutive women who underwent screening mammography were enrolled in this study. Seventy-nine subjects having BAC, aged 46-75 years, and 125 age-matched controls from those without BAC were selected for ultrasound examination of carotid arteries assessing intima-media thickness (IMT) and plaque presence. Participants were divided into three groups of risk including, low-risk: IMT 0.8 mm and/or plaque. Risk factors for atherosclerosis were obtained from medical records for independent effects. Results: BAC was present in 14.7% of mammograms. According to multivariable logistic regression analyses, significant association was identified between the carotid atherosclerosis risk and presence of BAC. Compared to women with IMT 0.8 mm had OR (95% CI) of 4.88 (1.47-16.16) and 23.36 (4.54-120.14), respectively. The OR (95% CI) for carotid plaque was 3.13 (1.3-7.57). There was no interaction between IMT category and plaque. Significant associations were also detected with postmenopausal duration (P = 0.02) and hypertension (P = 0.004). Conclusion: The risk of carotid atherosclerosis increases with the presence of BAC. Women with BAC are more likely to have thicker IMT than plaque, which could be attributed to the preferentially similar affected layer of media causing thick IMT rather than plaque.

  16. Tamoxifen up-regulates catalase production, inhibits vessel wall neutrophil infiltration, and attenuates development of experimental abdominal aortic aneurysms.

    Science.gov (United States)

    Grigoryants, Vladimir; Hannawa, Kevin K; Pearce, Charles G; Sinha, Indranil; Roelofs, Karen J; Ailawadi, Gorav; Deatrick, Kristopher B; Woodrum, Derek T; Cho, Brenda S; Henke, Peter K; Stanley, James C; Eagleton, Matthew J; Upchurch, Gilbert R

    2005-01-01

    controls on day 7 (P = .05). Administration of the direct catalase inhibitor AT to tamoxifen-treated rats partially reversed the aneurysm inhibitory effect of tamoxifen by nearly 30% (P = .02). In contrast, catalase administration inhibited AAA formation by 44% (P = .002). The selective estrogen receptor modulator tamoxifen inhibits the development of AAAs in male rats in association with an up-regulation of catalase and inhibition of aortic wall neutrophil infiltration.

  17. Presence of calcium in the vessel walls after end-to-end arterial anastomoses with polydioxanone and polypropylene sutures in growing dogs.

    Science.gov (United States)

    Gersak, B

    1993-10-01

    The presence of calcium in the vessel walls after end-to-end arterial anastomoses performed with polydioxanone and polypropylene interrupted sutures was studied in 140 anastomoses in 35 10-week-old German shepherd dogs. Histologic examination with hematoxylin and eosin, van Gieson, and von Kossa staining techniques was performed after the animals were killed 6 months after the operation. Ketamine hydrochloride was used as an anesthetic agent. At the start of the investigation the dogs weighed 14.5 +/- 2.6 kg (mean +/- standard deviation, n = 35), and after 6 months they weighed 45.3 +/- 3.1 kg (mean +/- standard deviation, n = 35). The diameter of the sutured arteries in the first operation was 2.6 +/- 0.5 mm (mean +/- standard deviation, n = 140). With each dog, both brachial and both femoral arteries were used--one artery for each different type of suture. In different dogs, different arteries were used for the same type of suture. The prevalence of calcifications after 6 months was determined from the numeric density of calcifications with standard stereologic techniques. The sutured and sutureless parts taken from longitudinal sections from each artery were studied, and t test values were calculated as follows: In paired samples, statistically significant differences in numerical density of calcifications were seen between sutured and sutureless arterial parts for both materials (sutureless part versus part with polydioxanone sutures, p 0.05, n = 70) and sutureless parts (p > 0.05, n = 70).

  18. Age determination of vessel wall hematoma in spontaneous cervical artery dissection: A multi-sequence 3T Cardiovascular Magnetic resonance study

    Science.gov (United States)

    2011-01-01

    Background Previously proposed classifications for carotid plaque and cerebral parenchymal hemorrhages are used to estimate the age of hematoma according to its signal intensities on T1w and T2w MR images. Using these classifications, we systematically investigated the value of cardiovascular magnetic resonance (CMR) in determining the age of vessel wall hematoma (VWH) in patients with spontaneous cervical artery dissection (sCAD). Methods 35 consecutive patients (mean age 43.6 ± 9.8 years) with sCAD received a cervical multi-sequence 3T CMR with fat-saturated black-blood T1w-, T2w- and TOF images. Age of sCAD was defined as time between onset of symptoms (stroke, TIA or Horner's syndrome) and the CMR scan. VWH were categorized into hyperacute, acute, early subacute, late subacute and chronic based on their signal intensities on T1w- and T2w images. Results The mean age of sCAD was 2.0, 5.8, 15.7 and 58.7 days in patients with acute, early subacute, late subacute and chronic VWH as classified by CMR (p hematomas with Cohen's kappa of 0.74 (p hematomas differs from that of cerebral hematomas. PMID:22122756

  19. Age determination of vessel wall hematoma in spontaneous cervical artery dissection: A multi-sequence 3T Cardiovascular Magnetic resonance study

    Directory of Open Access Journals (Sweden)

    Habs Maximilian

    2011-11-01

    Full Text Available Abstract Background Previously proposed classifications for carotid plaque and cerebral parenchymal hemorrhages are used to estimate the age of hematoma according to its signal intensities on T1w and T2w MR images. Using these classifications, we systematically investigated the value of cardiovascular magnetic resonance (CMR in determining the age of vessel wall hematoma (VWH in patients with spontaneous cervical artery dissection (sCAD. Methods 35 consecutive patients (mean age 43.6 ± 9.8 years with sCAD received a cervical multi-sequence 3T CMR with fat-saturated black-blood T1w-, T2w- and TOF images. Age of sCAD was defined as time between onset of symptoms (stroke, TIA or Horner's syndrome and the CMR scan. VWH were categorized into hyperacute, acute, early subacute, late subacute and chronic based on their signal intensities on T1w- and T2w images. Results The mean age of sCAD was 2.0, 5.8, 15.7 and 58.7 days in patients with acute, early subacute, late subacute and chronic VWH as classified by CMR (p Conclusions Signal intensities of VWH in sCAD vary over time and multi-sequence CMR can help to determine the age of an arterial dissection. Furthermore, findings of this study suggest that the time course of carotid hematomas differs from that of cerebral hematomas.

  20. Shear machines

    International Nuclear Information System (INIS)

    Astill, M.; Sunderland, A.; Waine, M.G.

    1980-01-01

    A shear machine for irradiated nuclear fuel elements has a replaceable shear assembly comprising a fuel element support block, a shear blade support and a clamp assembly which hold the fuel element to be sheared in contact with the support block. A first clamp member contacts the fuel element remote from the shear blade and a second clamp member contacts the fuel element adjacent the shear blade and is advanced towards the support block during shearing to compensate for any compression of the fuel element caused by the shear blade (U.K.)

  1. 4D Flow Analysis of BAV-Related Fluid-Dynamic Alterations: Evidences of Wall Shear Stress Alterations in Absence of Clinically-Relevant Aortic Anatomical Remodeling

    Directory of Open Access Journals (Sweden)

    Filippo Piatti

    2017-06-01

    Full Text Available Bicuspid aortic valve (BAV is the most common congenital cardiac disease and is a foremost risk factor for aortopathies. Despite the genetic basis of BAV and of the associated aortopathies, BAV-related alterations in aortic fluid-dynamics, and particularly in wall shear stresses (WSSs, likely play a role in the progression of aortopathy, and may contribute to its pathogenesis. To test whether WSS may trigger aortopathy, in this study we used 4D Flow sequences of phase-contrast cardiac magnetic resonance imaging (CMR to quantitatively compare the in vivo fluid dynamics in the thoracic aorta of two groups of subjects: (i five prospectively enrolled young patients with normo-functional BAV and with no aortic dilation and (ii ten age-matched healthy volunteers. Through the semi-automated processing of 4D Flow data, the aortic bulk flow at peak systole was quantified, and WSSs acting on the endothelium of the ascending aorta were characterized throughout the systolic phase in terms of magnitude and time-dependency through a method recently developed by our group. Variables computed for each BAV patient were compared vs. the corresponding distribution of values obtained for healthy controls. In BAV patients, ascending aorta diameter was measured on cine-CMR images at baseline and at 3-year follow-up. As compared to controls, normo-functional BAV patients were characterized by minor bulk flow disturbances at peak systole. However, they were characterized by evident alterations of WSS distribution and peak values in the ascending aorta. In particular, in four BAV patients, who were characterized by right-left leaflet fusion, WSS peak values exceeded by 27–46% the 90th percentile of the distribution obtained for healthy volunteers. Only in the BAV patient with right-non-coronary leaflet fusion the same threshold was exceeded by 132%. Also, evident alterations in the time-dependency of WSS magnitude and direction were observed. Despite, these fluid

  2. Echo Particle Image Velocimetry for Estimation of Carotid Artery Wall Shear Stress: Repeatability, Reproducibility and Comparison with Phase-Contrast Magnetic Resonance Imaging.

    Science.gov (United States)

    Gurung, Arati; Gates, Phillip E; Mazzaro, Luciano; Fulford, Jonathan; Zhang, Fuxing; Barker, Alex J; Hertzberg, Jean; Aizawa, Kunihiko; Strain, William D; Elyas, Salim; Shore, Angela C; Shandas, Robin

    2017-08-01

    Measurement of hemodynamic wall shear stress (WSS) is important in investigating the role of WSS in the initiation and progression of atherosclerosis. Echo particle image velocimetry (echo PIV) is a novel ultrasound-based technique for measuring WSS in vivo that has previously been validated in vitro using the standard optical PIV technique. We evaluated the repeatability and reproducibility of echo PIV for measuring WSS in the human common carotid artery. We measured WSS in 28 healthy participants (18 males and 10 females, mean age: 56 ± 12 y). Echo PIV was highly repeatable, with an intra-observer variability of 1.0 ± 0.1 dyn/cm 2 for peak systolic (maximum), 0.9 dyn/cm 2 for mean and 0.5 dyn/cm 2 for end-diastolic (minimum) WSS measurements. Likewise, echo PIV was reproducible, with a low inter-observer variability (max: 2.0 ± 0.2 dyn/cm 2 , mean: 1.3 ± 0.1 dyn/cm 2 , end-diastolic: 0.7 dyn/cm 2 ) and more variable inter-scan (test-retest) variability (max: 7.1 ± 2.3 dyn/cm 2 , mean: 2.9 ± 0.4 dyn/cm 2 , min: 1.5 ± 0.1 dyn/cm 2 ). We compared echo PIV with the reference method, phase-contrast magnetic resonance imaging (PC-MRI); echo PIV-based WSS measurements agreed qualitatively with PC-MRI measurements (r = 0.89, p PIV vs. PC-MRI): WSS at peak systole: 21 ± 7.0 dyn/cm 2 vs. 15 ± 5.0 dyn/cm 2 ; time-averaged WSS: 8.9 ± 3.0 dyn/cm 2 vs. 7.1 ± 3.0 dyn/cm 2 (p  0.05). For the first time, we report that echo PIV can measure WSS with good repeatability and reproducibility in adult humans with a broad age range. Echo PIV is feasible in humans and offers an easy-to-use, ultrasound-based, quantitative technique for measuring WSS in vivo in humans with good repeatability and reproducibility. Copyright © 2017. Published by Elsevier Inc.

  3. Multiple shell pressure vessel

    International Nuclear Information System (INIS)

    Wedellsborg, B.W.

    1988-01-01

    A method is described of fabricating a pressure vessel comprising the steps of: attaching a first inner pressure vessel having means defining inlet and outlet openings to a top flange, placing a second inner pressure vessel, having means defining inlet and outlet opening, concentric with and spaced about the first inner pressure vessel and attaching the second inner pressure vessel to the top flange, placing an outer pressure vessel, having inlet and outlet openings, concentric with and spaced apart about the second inner pressure vessel and attaching the outer pressure vessel to the top flange, attaching a generally cylindrical inner inlet conduit and a generally cylindrical inner outlet conduit respectively to the inlet and outlet openings in the first inner pressure vessel, attaching a generally cylindrical outer inlet conduit and a generally cylindrical outer outlet conduit respectively to the inlet and outlet opening in the second inner pressure vessel, heating the assembled pressure vessel to a temperature above the melting point of a material selected from the group, lead, tin, antimony, bismuth, potassium, sodium, boron and mixtures thereof, filling the space between the first inner pressure vessel and the second inner pressure vessel with material selected from the group, filling the space between the second inner pressure vessel and the outer pressure vessel with material selected from the group, and pressurizing the material filling the spaces between the pressure vessels to a predetermined pressure, the step comprising: pressurizing the spaces to a pressure whereby the wall of the first inner pressure vessel is maintained in compression during steady state operation of the pressure vessel

  4. Simulated Microgravity Regulates Gene Transcript Profiles of 2T3 Preosteoblasts: Comparison of the Random Positioning Machine and the Rotating Wall Vessel Bioreactor

    Science.gov (United States)

    Patel, Mamta J.; Liu, Wenbin; Sykes, Michelle C.; Ward, Nancy E.; Risin, Semyon A.; Risin, Diana; Hanjoong, Jo

    2007-01-01

    Microgravity of spaceflight induces bone loss due in part to decreased bone formation by osteoblasts. We have previously examined the microgravity-induced changes in gene expression profiles in 2T3 preosteoblasts using the Random Positioning Machine (RPM) to simulate microgravity conditions. Here, we hypothesized that exposure of preosteoblasts to an independent microgravity simulator, the Rotating Wall Vessel (RWV), induces similar changes in differentiation and gene transcript profiles, resulting in a more confined list of gravi-sensitive genes that may play a role in bone formation. In comparison to static 1g controls, exposure of 2T3 cells to RWV for 3 days inhibited alkaline phosphatase activity, a marker of differentiation, and downregulated 61 genes and upregulated 45 genes by more than two-fold as shown by microarray analysis. The microarray results were confirmed with real time PCR for downregulated genes osteomodulin, bone morphogenic protein 4 (BMP4), runx2, and parathyroid hormone receptor 1. Western blot analysis validated the expression of three downregulated genes, BMP4, peroxiredoxin IV, and osteoglycin, and one upregulated gene peroxiredoxin I. Comparison of the microarrays from the RPM and the RWV studies identified 14 gravi-sensitive genes that changed in the same direction in both systems. Further comparison of our results to a published database showing gene transcript profiles of mechanically loaded mouse tibiae revealed 16 genes upregulated by the loading that were shown to be downregulated by RWV and RPM. These mechanosensitive genes identified by the comparative studies may provide novel insights into understanding the mechanisms regulating bone formation and potential targets of countermeasure against decreased bone formation both in astronauts and in general patients with musculoskeletal disorders.

  5. Keyed shear joints

    DEFF Research Database (Denmark)

    Hansen, Klaus

    This report gives a summary of the present information on the behaviour of vertical keyed shear joints in large panel structures. An attemp is made to outline the implications which this information might have on the analysis and design of a complete wall. The publications also gives a short...

  6. Time resolved investigations on flow field and quasi wall shear stress of an impingement configuration with pulsating jets by means of high speed PIV and a surface hot wire array

    International Nuclear Information System (INIS)

    Janetzke, Timm; Nitsche, Wolfgang

    2009-01-01

    The effects of jet pulsation on flow field and quasi wall shear stress of an impingement configuration were investigated experimentally. The excitation Strouhal number and amplitude were varied as the most influential parameters. A line-array with three submerged air jets, and a confining plate were used. The flow field analysis by means of time resolved particle image velocimetry shows that the controlled excitation can considerably affect the near-field flow of an impinging jet array. These effects are visualized as organization of the coherent flow structures. Augmentation of the Kelvin-Helmholtz vortices in the jet shear layer depends on the Strouhal number and pulsation magnitude and can be associated with pairing of small scale vortices in the jet. A total maximum of vortex strength was observed when exciting with Sr = 0.82 and coincident high amplitudes. Time resolved interaction between impinging vortices and impingement plate boundary layer due to jet excitation was verified by using an array of 5 μm surface hot wires. Corresponding to the global flow field modification due to periodic jet pulsation, the impact of the vortex rings on the wall boundary layer is highly influenced by the above mentioned excitation parameters and reaches a maximum at Sr = 0.82.

  7. Transitional Flow in an Arteriovenous Fistula: Effect of Wall Distensibility

    Science.gov (United States)

    McGah, Patrick; Leotta, Daniel; Beach, Kirk; Aliseda, Alberto

    2012-11-01

    Arteriovenous fistulae are created surgically to provide adequate access for dialysis in patients with end-stage renal disease. Transitional flow and the subsequent pressure and shear stress fluctuations are thought to be causative in the fistula failure. Since 50% of fistulae require surgical intervention before year one, understanding the altered hemodynamic stresses is an important step toward improving clinical outcomes. We perform numerical simulations of a patient-specific model of a functioning fistula reconstructed from 3D ultrasound scans. Rigid wall simulations and fluid-structure interaction simulations using an in-house finite element solver for the wall deformations were performed and compared. In both the rigid and distensible wall cases, transitional flow is computed in fistula as evidenced by aperiodic high frequency velocity and pressure fluctuations. The spectrum of the fluctuations is much more narrow-banded in the distensible case, however, suggesting a partial stabilizing effect by the vessel elasticity. As a result, the distensible wall simulations predict shear stresses that are systematically 10-30% lower than the rigid cases. We propose a possible mechanism for stabilization involving the phase lag in the fluid work needed to deform the vessel wall. Support from an NIDDK R21 - DK08-1823.

  8. Elevated Shear Stress in Arteriovenous Fistulae: Is There Mechanical Homeostasis?

    Science.gov (United States)

    McGah, Patrick; Leotta, Daniel; Beach, Kirk; Aliseda, Alberto

    2011-11-01

    Arteriovenous fistulae are created surgically to provide access for dialysis in patients with renal failure. The current hypothesis is that the rapid remodeling occurring after the fistula creation is in part a process to restore the mechanical stresses to some preferred level (i.e. mechanical homeostasis). Given that nearly 50% of fistulae require an intervention after one year, understanding the altered hemodynamic stress is important in improving clinical outcomes. We perform numerical simulations of four patient-specific models of functioning fistulae reconstructed from 3D Doppler ultrasound scans. Our results show that the vessels are subjected to `normal' shear stresses away from the anastomosis; about 1 Pa in the veins and about 2.5 Pa in the arteries. However, simulations show that part of the anastomoses are consistently subjected to very high shear stress (>10Pa) over the cardiac cycle. These elevated values shear stresses are caused by the transitional flows at the anastomoses including flow separation and quasiperiodic vortex shedding. This suggests that the remodeling process lowers shear stress in the fistula but that it is limited as evidenced by the elevated shear at the anastomoses. This constant insult on the arterialized venous wall may explain the process of late fistula failure in which the dialysis access become occluded after years of use. Supported by an R21 Grant from NIDDK (DK081823).

  9. Streaming flow from ultrasound contrast agents by acoustic waves in a blood vessel model.

    Science.gov (United States)

    Cho, Eunjin; Chung, Sang Kug; Rhee, Kyehan

    2015-09-01

    To elucidate the effects of streaming flow on ultrasound contrast agent (UCA)-assisted drug delivery, streaming velocity fields from sonicated UCA microbubbles were measured using particle image velocimetry (PIV) in a blood vessel model. At the beginning of ultrasound sonication, the UCA bubbles formed clusters and translated in the direction of the ultrasound field. Bubble cluster formation and translation were faster with 2.25MHz sonication, a frequency close to the resonance frequency of the UCA. Translation of bubble clusters induced streaming jet flow that impinged on the vessel wall, forming symmetric vortices. The maximum streaming velocity was about 60mm/s at 2.25MHz and decreased to 15mm/s at 1.0MHz for the same acoustic pressure amplitude. The effect of the ultrasound frequency on wall shear stress was more noticeable. Maximum wall shear stress decreased from 0.84 to 0.1Pa as the ultrasound frequency decreased from 2.25 to 1.0MHz. The maximum spatial gradient of the wall shear stress also decreased from 1.0 to 0.1Pa/mm. This study showed that streaming flow was induced by bubble cluster formation and translation and was stronger upon sonication by an acoustic wave with a frequency near the UCA resonance frequency. Therefore, the secondary radiant force, which is much stronger at the resonance frequency, should play an important role in UCA-assisted drug delivery. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. An In Vitro Comparative Study of Intracanal Fluid Motion and Wall Shear Stress Induced by Ultrasonic and Polymer Rotary Finishing Files in a Simulated Root Canal Model

    OpenAIRE

    Koch, Jon; Borg, John; Mattson, Abby; Olsen, Kris; Bahcall, James

    2012-01-01

    Objective. This in vitro study compared the flow pattern and shear stress of an irrigant induced by ultrasonic and polymer rotary finishing file activation in an acrylic root canal model. Flow visualization analysis was performed using an acrylic canal filled with a mixture of distilled water and rheoscopic fluid. The ultrasonic and polymer rotary finishing file were separately tested in the canal and activated in a static position and in a cyclical axial motion (up and down). Particle moveme...

  11. Nuclear reactor vessel inspection apparatus

    International Nuclear Information System (INIS)

    Blackstone, E.G.; Lofy, R.A.; Williams, L.P.

    1979-01-01

    Apparatus for the in situ inspection of a nuclear reactor vessel to detect the location and character of flaws in the walls of the vessel, in the welds joining the various sections of the vessel, in the welds joining attachments such as nozzles, elbows and the like to the reactor vessel and in such attachments wherein an inspection head carrying one or more ultrasonic transducers follows predetermined paths in scanning the various reactor sections, welds and attachments

  12. Vessel Operating Units (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains data for vessels that are greater than five net tons and have a current US Coast Guard documentation number. Beginning in1979, the NMFS...

  13. Application of a soft computing technique in predicting the percentage of shear force carried by walls in a rectangular channel with non-homogeneous roughness.

    Science.gov (United States)

    Khozani, Zohreh Sheikh; Bonakdari, Hossein; Zaji, Amir Hossein

    2016-01-01

    Two new soft computing models, namely genetic programming (GP) and genetic artificial algorithm (GAA) neural network (a combination of modified genetic algorithm and artificial neural network methods) were developed in order to predict the percentage of shear force in a rectangular channel with non-homogeneous roughness. The ability of these methods to estimate the percentage of shear force was investigated. Moreover, the independent parameters' effectiveness in predicting the percentage of shear force was determined using sensitivity analysis. According to the results, the GP model demonstrated superior performance to the GAA model. A comparison was also made between the GP program determined as the best model and five equations obtained in prior research. The GP model with the lowest error values (root mean square error ((RMSE) of 0.0515) had the best function compared with the other equations presented for rough and smooth channels as well as smooth ducts. The equation proposed for rectangular channels with rough boundaries (RMSE of 0.0642) outperformed the prior equations for smooth boundaries.

  14. Contribution to the understanding of the behaviour of reinforced concrete shear walls under seismic loading: contribution of experiment and modeling to the design; Contribution a la comprehension du fonctionnement des voiles en beton arme sous sollicitation sismique: apport de l'experimentation et de la modelisation a la conception

    Energy Technology Data Exchange (ETDEWEB)

    Ile, N

    2000-12-01

    This thesis deals with aspects of seismic behaviour of reinforced concrete shear walls (RCSW). Its objective is to introduce a useful modelling approach for addressing the non-linear response of a large variety of RCSW and to identify several aspects in which this numerical approach could be implemented into design applications. Firstly, the characteristics of the behaviour of RCSW under seismic loading, some design principles and different modelling approaches are discussed. As an important lack of knowledge in several fields was identified, it was considered that three types of shear walls deserve more attention: slightly reinforced slender walls; U-shaped walls and heavily reinforced squat shear walls. A local modelling approach is adopted and the material constitutive models are described in details. Secondly, the behaviour of the two mock-up, CAMUS I and II, tested on the shaking-table during the CAMUS programme, which are slightly reinforced and designed according to the French code PS92 is simulated using a 2-D finite element model (FEM). For comparison purposes, the case of the CAMUS III mock-up, designed according to EC8, is considered. We are then dealing with the case of U-shaped walls under dynamic and cyclic loading. The results obtained from numerical simulations, based on a 3-D shell FEM, are compared with those obtained from tests carried out in the frame of the ICONS programme. Finally, the numerical model is applied to the case of heavily reinforced squat shear walls (similar to those used in the nuclear power plant buildings) subjected to shear loading. A 2-D FEM is considered in order to simulate the behaviour of three different walls, which were tested pseudo-dynamically during the SAFE programme. The results from both experimental and numerical studies are compared and discussed. The most important factors affecting the behaviour of RCSW are highlighted. Different examples of possible contributions to design are presented. (author)

  15. Contribution to the understanding of the behaviour of reinforced concrete shear walls under seismic loading: contribution of experiment and modeling to the design; Contribution a la comprehension du fonctionnement des voiles en beton arme sous sollicitation sismique: apport de l'experimentation et de la modelisation a la conception

    Energy Technology Data Exchange (ETDEWEB)

    Ile, N

    2000-12-01

    This thesis deals with aspects of seismic behaviour of reinforced concrete shear walls (RCSW). Its objective is to introduce a useful modelling approach for addressing the non-linear response of a large variety of RCSW and to identify several aspects in which this numerical approach could be implemented into design applications. Firstly, the characteristics of the behaviour of RCSW under seismic loading, some design principles and different modelling approaches are discussed. As an important lack of knowledge in several fields was identified, it was considered that three types of shear walls deserve more attention: slightly reinforced slender walls; U-shaped walls and heavily reinforced squat shear walls. A local modelling approach is adopted and the material constitutive models are described in details. Secondly, the behaviour of the two mock-up, CAMUS I and II, tested on the shaking-table during the CAMUS programme, which are slightly reinforced and designed according to the French code PS92 is simulated using a 2-D finite element model (FEM). For comparison purposes, the case of the CAMUS III mock-up, designed according to EC8, is considered. We are then dealing with the case of U-shaped walls under dynamic and cyclic loading. The results obtained from numerical simulations, based on a 3-D shell FEM, are compared with those obtained from tests carried out in the frame of the ICONS programme. Finally, the numerical model is applied to the case of heavily reinforced squat shear walls (similar to those used in the nuclear power plant buildings) subjected to shear loading. A 2-D FEM is considered in order to simulate the behaviour of three different walls, which were tested pseudo-dynamically during the SAFE programme. The results from both experimental and numerical studies are compared and discussed. The most important factors affecting the behaviour of RCSW are highlighted. Different examples of possible contributions to design are presented. (author)

  16. Behavior of cracked concrete nuclear containment vessels during earthquakes

    International Nuclear Information System (INIS)

    Gergely, P.; Stanton, J.F.; White, R.N.

    1975-01-01

    When pressure builds up in a reinforced concrete nuclear containment shell, its cylindrical wall cracks vertically and horizontally at intervals of about five feet. If an earthquake occurs simultaneously with this pressurization, inertia forces are transmitted across the horizontal crack planes. The forces and deformations must be small enough to maintain the integrity of the steel liner. A typical containment shell has a radius of about 65 ft. and a wall thickness of about 4 ft. It is heavily reinforced with vertical, horizontal, and sometimes diagonal bars. A steel shell of about 3 / 8 in. thickness is attached to the concrete with anchors. The seismic shear forces are transmitted across the horizontal cracks by interface shear transfer (combination of shear friction and aggregate interlocking), by dowel action of the bars, and by diagonal bars if they are used. One important question in the design of such vessels is whether the diagonal bars are necessary. In the experimental portion of the current investigation several types of tests were conducted to study the load-slip characteristics of interface shear transfer under high intensity cyclic loading. In some cases external bars provided the clamping action of reinforcement, in more recent tests large diameter embedded bars were used. This presentation summarizes the analytical part of the investigation. A representative load-slip curve has been used in the analyses to assess the intensity of the stresses and deformations, and to study the importance of the variables as an aid in planning future tests

  17. Tumor Blood Vessel Dynamics

    Science.gov (United States)

    Munn, Lance

    2009-11-01

    ``Normalization'' of tumor blood vessels has shown promise to improve the efficacy of chemotherapeutics. In theory, anti-angiogenic drugs targeting endothelial VEGF signaling can improve vessel network structure and function, enhancing the transport of subsequent cytotoxic drugs to cancer cells. In practice, the effects are unpredictable, with varying levels of success. The predominant effects of anti-VEGF therapies are decreased vessel leakiness (hydraulic conductivity), decreased vessel diameters and pruning of the immature vessel network. It is thought that each of these can influence perfusion of the vessel network, inducing flow in regions that were previously sluggish or stagnant. Unfortunately, when anti-VEGF therapies affect vessel structure and function, the changes are dynamic and overlapping in time, and it has been difficult to identify a consistent and predictable normalization ``window'' during which perfusion and subsequent drug delivery is optimal. This is largely due to the non-linearity in the system, and the inability to distinguish the effects of decreased vessel leakiness from those due to network structural changes in clinical trials or animal studies. We have developed a mathematical model to calculate blood flow in complex tumor networks imaged by two-photon microscopy. The model incorporates the necessary and sufficient components for addressing the problem of normalization of tumor vasculature: i) lattice-Boltzmann calculations of the full flow field within the vasculature and within the tissue, ii) diffusion and convection of soluble species such as oxygen or drugs within vessels and the tissue domain, iii) distinct and spatially-resolved vessel hydraulic conductivities and permeabilities for each species, iv) erythrocyte particles advecting in the flow and delivering oxygen with real oxygen release kinetics, v) shear stress-mediated vascular remodeling. This model, guided by multi-parameter intravital imaging of tumor vessel structure

  18. In-vessel tritium

    International Nuclear Information System (INIS)

    Ueda, Yoshio; Ohya, Kaoru; Ashikawa, Naoko; Ito, Atsushi M.; Kato, Daiji; Kawamura, Gakushi; Takayama, Arimichi; Tomita, Yukihiro; Nakamura, Hiroaki; Ono, Tadayoshi; Kawashima, Hisato; Shimizu, Katsuhiro; Takizuka, Tomonori; Nakano, Tomohide; Nakamura, Makoto; Hoshino, Kazuo; Kenmotsu, Takahiro; Wada, Motoi; Saito, Seiki; Takagi, Ikuji; Tanaka, Yasunori; Tanabe, Tetsuo; Yoshida, Masafumi; Toma, Mitsunori; Hatayama, Akiyoshi; Homma, Yuki; Tolstikhina, Inga Yu.

    2012-01-01

    The in-vessel tritium research is closely related to the plasma-materials interaction. It deals with the edge-plasma-wall interaction, the wall erosion, transport and re-deposition of neutral particles and the effect of neutral particles on the fuel recycling. Since the in-vessel tritium shows a complex nonlinear behavior, there remain many unsolved problems. So far, behaviors of in-vessel tritium have been investigated by two groups A01 and A02. The A01 group performed experiments on accumulation and recovery of tritium in thermonuclear fusion reactors and the A02 group studied theory and simulation on the in-vessel tritium behavior. In the present article, outcomes of the research are reviewed. (author)

  19. Stiffness of reinforced concrete walls resisting in-place shear -- Tier 2: Aging and durability of concrete used in nuclear power plants. Final report

    International Nuclear Information System (INIS)

    Monteiro, P.J.M.; Moehle, J.P.

    1995-12-01

    Reinforced concrete walls are commonly used in power-plant construction to resist earthquake effects. Determination of wall stiffness is of particular importance for establishing design forces on attached equipment. Available experimental data indicate differences between the measured and calculated stiffness of walls in cases where concrete mechanical properties are well defined. Additional data indicate that in-situ concrete mechanical properties may differ significantly from those specified in design. The work summarized in this report was undertaken to investigate the mechanical properties of concrete considering aging and deterioration. Existing data on mechanical properties of concrete are evaluated, and new tests are carried out on concrete cylinders batched for nuclear power plants and stored under controlled conditions for up to twenty years. It is concluded that concretes batched for nuclear power plants commonly have 28-day strength that exceeds the design value by at least 1000 psi. Under curing conditions representative of those in the interior of thick concrete elements, strength gain with time can be estimated conservatively using the expression proposed by ACI Committee 209, with strengths at 25 years being approximately 1.3 times the 28-day strength. Young's modulus can be estimated using the expression given by ACI Committee 318. Variabilities in mechanical properties are identified. A review of concrete durability identified the main causes and results of concrete deterioration that are relevant for the class of concretes and structures commonly used in nuclear power plants. Prospects for identifying the occurrence and predicting the extent of deterioration are discussed

  20. Relative viscosity of emulsions in simple shear flow: Temperature, shear rate, and interfacial tension dependence

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Se Bin; Lee, Joon Sang [Dept. of Mechanical Engineering, Yonsei Unversity, Seoul (Korea, Republic of)

    2015-08-15

    We simulate an emulsion system under simple shear rates to analyze its rheological characteristics using the lattice Boltzmann method (LBM). We calculate the relative viscosity of an emulsion under a simple shear flow along with changes in temperature, shear rate, and surfactant concentration. The relative viscosity of emulsions decreased with an increase in temperature. We observed the shear-thinning phenomena, which is responsible for the inverse proportion between the shear rate and viscosity. An increase in the interfacial tension caused a decrease in the relative viscosity of the decane-in-water emulsion because the increased deformation caused by the decreased interfacial tension significantly influenced the wall shear stress.

  1. Vacuum vessel for thermonuclear device

    International Nuclear Information System (INIS)

    Kikuchi, Mitsuru; Kurita, Gen-ichi; Onozuka, Masaki; Suzuki, Masaru.

    1997-01-01

    Heat of inner walls of a vacuum vessel that receive radiation heat from plasmas by way of first walls is removed by a cooling medium flowing in channels for cooling the inner walls. Nuclear heat generation of constitutional materials of the vacuum vessel caused by fast neutrons and γ rays is removed by a cooling medium flowing in cooling channels disposed in the vacuum vessel. Since the heat from plasmas and the nuclear heat generation are removed separately, the amount of the cooling medium flowing in the channels for cooling inner walls is increased for cooling a great amount of heat from plasmas while the amount of the cooling medium flowing in the channels for cooling the inside of the vacuum vessel is reduced for cooling the small amount of nuclear heat generation. Since the amount of the cooling medium can thus be optimized, the capacity of the facilities for circulating the cooling medium can be reduced. In addition, since the channels for cooling the inner walls and the channels of cooling medium formed in the vacuum vessel are disposed to the inner walls of the vacuum vessel on the side opposite to plasmas, integrity of the channels relative to leakage of the cooling medium can be ensured. (N.H.)

  2. Vacuum vessel for thermonuclear device

    Energy Technology Data Exchange (ETDEWEB)

    Kikuchi, Mitsuru; Kurita, Gen-ichi [Japan Atomic Energy Research Inst., Tokyo (Japan); Onozuka, Masaki; Suzuki, Masaru

    1997-07-31

    Heat of inner walls of a vacuum vessel that receive radiation heat from plasmas by way of first walls is removed by a cooling medium flowing in channels for cooling the inner walls. Nuclear heat generation of constitutional materials of the vacuum vessel caused by fast neutrons and {gamma} rays is removed by a cooling medium flowing in cooling channels disposed in the vacuum vessel. Since the heat from plasmas and the nuclear heat generation are removed separately, the amount of the cooling medium flowing in the channels for cooling inner walls is increased for cooling a great amount of heat from plasmas while the amount of the cooling medium flowing in the channels for cooling the inside of the vacuum vessel is reduced for cooling the small amount of nuclear heat generation. Since the amount of the cooling medium can thus be optimized, the capacity of the facilities for circulating the cooling medium can be reduced. In addition, since the channels for cooling the inner walls and the channels of cooling medium formed in the vacuum vessel are disposed to the inner walls of the vacuum vessel on the side opposite to plasmas, integrity of the channels relative to leakage of the cooling medium can be ensured. (N.H.)

  3. Review on Seismic Rehabilitation of a 56-Story RC Tall Building having Shear Wall System Based on A Nonlinear Dynamic Performance Evaluation

    International Nuclear Information System (INIS)

    Epackachi, S.; Esmaili, O.; Mirghaderi, S. R.; Taheri, A. A.

    2008-01-01

    Tehran tower is a 56 story reinforced concrete tall building consisting of three wings with identical plan dimensions each approximately 48 meters by 22 meters. The three wings are at 120 degree from each other and have no expansions/seismic Joints. This paper contains the consideration of the retrofitting of the Tehran tower based on the findings of an exhaustive investigation of the nonlinear performance evaluation efforts. It has tried to show the procedure followed, methodologies utilized, and the results obtained for life-safety and collapse-prevention evaluation of the building. More over the weak zones of the structure due to analysis results are introduced and appropriate retrofit technique for satisfaction related life-safety and collapse-prevention criteria is presented. Actually in this project to improve the local behavior of coupling panels which are located regularly in main walls and definitely have been recognized as the most vulnerable structural elements, making use of steel plates which are connected to concrete members by chemical anchors has been used as the best retrofitting method for this case. Therefore in the final section of this paper it has been tried to explain the professional practical method utilized to perform the mentioned retrofitting project

  4. An underwater shear compactor

    International Nuclear Information System (INIS)

    Biver, E.; Sims, J.

    1997-01-01

    This paper, originally presented at the WM'96 Conference in Tucson Arizona, describes a concept of a specialised decommissioning tool designed to operate underwater and to reduce the volume of radioactive components by shearing and compacting. The shear compactor was originally conceived to manage the size reduction of a variety of decommissioned stainless steel tubes stored within a reactor fuel cooling pond and which were consuming a substantial volume of the pond. The main objective of this tool was to cut the long tubes into shorter lengths and to compact them into a flat rectangular form which could be stacked on the pond floor, thus saving valuable space. The development programme, undertaken on this project, investigated a wide range of factors which could contribute to an extended cutting blade performance, ie: materials of construction, cutting blade shape and cutting loads required, shock effects, etc. The second phase was to review other aspects of the design, such as radiological protection, cutting blade replacement, maintenance, pond installation and resultant wall loads, water hydraulics, collection of products of shearing/compacting operations, corrosion of the equipment, control system, operational safety and the ability of the equipment to operate in dry environments. The paper summarises the extended work programme involved with this shear compactor tool. (author)

  5. Effects of High-sugar and High-fat Diet on Fat Deposition and Blood Vessel Wall on Sprague Dawley Rats Liver

    Directory of Open Access Journals (Sweden)

    Vera Citra Setiawan Hoei

    2013-11-01

    Full Text Available People nowadays tend to consume more fast food and sweetened beverages. These foods usually contain high amount sugar and fat that have effects on the body including liver.This study was conducted to explore the effects of extensive intake of sugar and fat on blood glucose and  cholesterol level as well as changes in liver. Research was conducted with experimental method using 20 Sprague Dawley rats which were divided into 4 groups; 2 controls and 2 treatments. Rats were given 5 ml sugar or lard alternatively every 2 consecutive days for 1-month and 2-month respectively. Data was retrieved include blood glucose and cholesterol level, fatty liver percentage and blood vessel thickening after intervention through HE staining. The results showed that both 1-month and 2-month intervention group has significant increase in blood glucose and cholesterol level. However, the enhancement of fatty liver percentage and number of thickened blood vessels (p<0.05 were only foundsignificant (p<0.05 in 1-month intervention group.  We concluded that high intake of sugar and fat within 1-monthintervention have significant effects on the rat body including liver. Nevertheless, it was not found significant in 2-months intervention. Further studies are still needed to analyze this incongruent result.Key words: high-sugar diet, high-fat diet, fatty liver, atherosclerosis 

  6. Simulations of Granular Particles Under Cyclic Shear

    Science.gov (United States)

    Royer, John; Chaikin, Paul

    2012-02-01

    We perform molecular dynamics (MD) simulations of spherical grains subjected to cyclic, quasi-static shear in a 3D parallelepiped shear cell. This virtual shear cell is constructed out of rough, bumpy walls in order to minimize wall-induced ordering and has an open top surface to allow the packing to readily dilate or compact. Using a standard routine for MD simulations of frictional grains, we simulate over 1000 shear cycles, measuring grain displacements, the local packing density and changes in the contact network. Varying the shear amplitude and the friction coefficient between grains, we map out a phase diagram for the different types of behavior exhibited by these sheared grains. With low friction and high enough shear, the grains can spontaneously order into densely packed crystals. With low shear and increasing friction the packing remains disordered, yet the grains arrange themselves into configurations which exhibit limit cycles where all grains return to the same position after each full shear cycle. At higher shear and friction there is a transition to a diffusive state, where grains continue rearrange and move throughout the shear cell.

  7. Research vessels

    Digital Repository Service at National Institute of Oceanography (India)

    Rao, P.S.

    The role of the research vessels as a tool for marine research and exploration is very important. Technical requirements of a suitable vessel and the laboratories needed on board are discussed. The history and the research work carried out...

  8. Vacuum vessel for plasma devices

    International Nuclear Information System (INIS)

    Yamada, Masao; Taguchi, Masami.

    1975-01-01

    Object: To permit effective utility of the space in the inner and outer sides of the container wall and also permit repeated assembly for use. Structure: Vacuum vessel wall sections are sealed together by means of welding bellows, and also flange portions formed at the end of the wall sections are coupled together by bolts and are sealed together with a seal ring and a seal cap secured by welding. (Nakamura, S.)

  9. Hydrostatic pressure and shear stress affect endothelin-1 and nitric oxide release by endothelial cells in bioreactors.

    Science.gov (United States)

    Vozzi, Federico; Bianchi, Francesca; Ahluwalia, Arti; Domenici, Claudio

    2014-01-01

    Abundant experimental evidence demonstrates that endothelial cells are sensitive to flow; however, the effect of fluid pressure or pressure gradients that are used to drive viscous flow is not well understood. There are two principal physical forces exerted on the blood vessel wall by the passage of intra-luminal blood: pressure and shear. To analyze the effects of pressure and shear independently, these two stresses were applied to cultured cells in two different types of bioreactors: a pressure-controlled bioreactor and a laminar flow bioreactor, in which controlled levels of pressure or shear stress, respectively, can be generated. Using these bioreactor systems, endothelin-1 (ET-1) and nitric oxide (NO) release from human umbilical vein endothelial cells were measured under various shear stress and pressure conditions. Compared to the controls, a decrease of ET-1 production by the cells cultured in both bioreactors was observed, whereas NO synthesis was up-regulated in cells under shear stress, but was not modulated by hydrostatic pressure. These results show that the two hemodynamic forces acting on blood vessels affect endothelial cell function in different ways, and that both should be considered when planning in vitro experiments in the presence of flow. Understanding the individual and synergic effects of the two forces could provide important insights into physiological and pathological processes involved in vascular remodeling and adaptation. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Low Fluid Shear Culture of Staphylococcus Aureus Represses hfq Expression and Induces an Attachment-Independent Biofilm Phenotype

    Science.gov (United States)

    Ott, C. Mark; Castro, S. L.; Nickerson, C. A.; Nelman-Gonzalez, M.

    2011-01-01

    Background: The opportunistic pathogen, Staphylococcus aureus, experiences fluctuations in fluid shear during infection and colonization of a human host. Colonization frequently occurs at mucus membrane sites such as in the gastrointestinal tract where the bacterium may experience low levels of fluid shear. The response of S. aureus to low fluid shear remains unclear. Methods: S. aureus was cultured to stationary phase using Rotating-Wall Vessel (RWV) bioreactors which produce a physiologically relevant low fluid shear environment. The bacterial aggregates that developed in the RWV were evaluated by electron microscopy as well as for antibiotic resistance and other virulence-associated stressors. Genetic expression profiles for the low-shear cultured S. aureus were determined by microarray analysis and quantitative real-time PCR. Results: Planktonic S. aureus cultures in the low-shear environment formed aggregates completely encased in high amounts of extracellular polymeric substances. In addition, these aggregates demonstrated increased antibiotic resistance indicating attachment-independent biofilm formation. Carotenoid production in the low-shear cultured S. aureus was significantly decreased, and these cultures displayed an increased susceptibility to oxidative stress and killing by whole blood. The hfq gene, associated with low-shear growth in Gram negative organisms, was also found to be down-regulated in S. aureus. Conclusions: Collectively, this data suggests that S. aureus decreases virulence characteristics in favor of a biofilm-dwelling colonization phenotype in response to a low fluid shear environment. Furthermore, the identification of an Hfq response to low-shear culture in S. aureus, in addition to the previously reported responses in Gram negative organisms, strongly suggests an evolutionarily conserved response to mechanical stimuli among structurally diverse prokaryotes.

  11. Voluntary Consensus Organization Standards for Nondestructive Evaluation of Thin-Walled Metallic Liners and Composite Overwraps in Composite Overwrapped Pressure Vessels

    Science.gov (United States)

    Waller, Jess; Saulsberry, Regor

    2012-01-01

    NASA fracture control requirements outlined in NASA-STD-5009 and NASA-STD-5014 are predicated on the availability and use of sensitive nondestructive evaluation (NDE) methods that can detect and monitor defects, thereby providing data that can be used to predict failure or reduce the risk of failure in fracture critical components. However, in the case of composite materials and components, including composite overwrapped pressure vessels (COPVs), the effect of defects is poorly understood, the NDE methods used to evaluate locate and size defects are typically at lower technical readiness level than analogous NDE methods used for metals, and demonstration studies to verify the probability of detection (POD) are generally lacking or unavailable. These factors together make failure prediction of fracture critical composite materials and components based on size, quantity, or orientation of defects nearly impossible. Also, when inspecting metal liners in as-manufactured COPVs, sensitivity is lost and only the inner surface of the liner is accessible. Also, NDE of COPVs as applied during manufacturing varies significantly from manufacturer to manufacturer and has not yet been standardized. Although requirements exist to perform NDE immediately after manufacturing to establish initial integrity of the parts, procedural detail for NDE of composites is still nonexistent or under development. For example, in practice, only a visual inspection of COPVs is performed during manufacturing and service, leaving in question whether defects of concern, for example, bridging, overwrap winding anomalies, impact damage below visible threshold, out-of-family strain growth, and liner buckling have been adequately detected and monitored. To address these shortcomings, in 2005 the NASA Nondestructive Evaluation Working Group (NNWG) began funding work to develop and adopt standards for nondestructive evaluation of aerospace composites in collaboration with the American Society for Testing

  12. Computational and experimental assessment of influences of hemodynamic shear stress on carotid plaque.

    Science.gov (United States)

    Zhou, Hui; Meng, Long; Zhou, Wei; Xin, Lin; Xia, Xiangxiang; Li, Shuai; Zheng, Hairong; Niu, Lili

    2017-07-29

    Studies have identified hemodynamic shear stress as an important determinant of endothelial function and atherosclerosis. In this study, we assess the influences of hemodynamic shear stress on carotid plaques. Carotid stenosis phantoms with three severity (30, 50, 70%) were made from 10% polyvinyl alcohol (PVA) cryogel. The phantoms were placed in a pulsatile flow loop with the same systolic/diastolic phase (35/65) and inlet flow rate (16 L/h). Ultrasonic particle imaging velocimetry (Echo PIV) and computational fluid dynamics (CFD) were used to calculate the velocity profile and shear stress distribution in the carotid stenosis phantoms. Inlet/outlet boundary conditions used in CFD were extracted from Echo PIV experiments to make sure that the results were comparable. Echo PIV and CFD results showed that velocity was largest in 70% than those in 30 and 50% at peak systole. Echo PIV results indicated that shear stress was larger in the upper wall and the surface of plaque than in the center of vessel. CFD results demonstrated that wall shear stress in the upstream was larger than in downstream of plaque. There was no significant difference in average velocity obtained by CFD and Echo PIV in 30% (p = 0.25). Velocities measured by CFD in 50% (93.01 cm/s) and in 70% (115.07 cm/s) were larger than those by Echo PIV in 50% (60.26 ± 5.36 cm/s) and in 70% (89.11 ± 7.21 cm/s). The results suggested that Echo PIV and CFD could obtain hemodynamic shear stress on carotid plaques. Higher WSS occurred in narrower arteries, and the shoulder of plaque bore higher WSS than in bottom part.

  13. Modelling of in-vessel retention after relocation of corium into the lower plenum - Evaluation of the temperature field and of the viscoplastic deformation of the vessel wall. Reactor safety research, project No.:150 1254 - Final report; Beitrag zur Modellierung der Schmelzerueckhaltung im RDB nach Verlagerung von Corium in das untere Plenum - Berechnung des Temperaturfeldes und der viskoplastischen Verformung der Behaelterwand. Reaktorsicherheitsforschung, Vorhaben-Nr.: 150 1254 - Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Altstadt, E.; Willschuetz, H.G. [Forschungszentrum Rossendorf e.V. (FZR), Dresden (Germany)

    2005-01-01

    Considering the hypothetical core melt down scenario for a light water reactor (LWR) a possible failure mode of the reactor pressure vessel (RPV) and its failure time has to be investigated for a determination of the loadings on the containment. Several experiments have been performed accompanied with material properties evaluation, theoretical, and numerical work. At the Institute Of Safety Research of the FZR a finite element model has been developed simulating the thermal processes and the viscoplastic behaviour of the vessel wall. An advanced model for creep and material damage has been established and has been validated using experimental data. The thermal hydraulic and the mechanical calculations are sequentially and recursively coupled. The model is capable of evaluating fracture time and fracture position of a vessel with an internally heated melt pool. The model was applied to pre- and post test calculations for the FOREVER test series representing the RPV of a PWR in the scale of 1:10. These experiments were performed at the Royal Institute of Technology in Stockholm. The results of the calculations can be summarised as follows: The creeping process is caused by the simultaneous presence of high temperature (>600 C) and pressure (>1 MPa). The hot focus region is the most endangered zone exhibiting the highest creep strain rates. The exact level of temperature and pressure has an influence on the vessel failure time but not on the failure position. The failure time can be predicted with an uncertainty of 20 to 25%. This uncertainty is caused by the large scatter and the high temperature sensitivity of the viscoplastic properties of the RPV steel. Contrary to the hot focus region, the lower centre of the vessel head exhibits a higher strength because of the lower temperatures in this zone. The lower part moves down without significant deformation. Therefore it can be assumed, that the vessel failure can be retarded or prevented by supporting this range. The

  14. Radioactive liquid containing vessel

    International Nuclear Information System (INIS)

    Sakurada, Tetsuo; Kawamura, Hironobu.

    1993-01-01

    Cooling jackets are coiled around the outer circumference of a container vessel, and the outer circumference thereof is covered with a surrounding plate. A liquid of good conductivity (for example, water) is filled between the cooling jackets and the surrounding plate. A radioactive liquid is supplied to the container vessel passing through a supply pipe and discharged passing through a discharge pipe. Cooling water at high pressure is passed through the cooling water jackets in order to remove the heat generated from the radioactive liquid. Since cooling water at high pressure is thus passed through the coiled pipes, the wall thickness of the container vessel and the cooling water jackets can be reduced, thereby enabling to reduce the cost. Further, even if the radioactive liquid is leaked, there is no worry of contaminating cooling water, to prevent contamination. (I.N.)

  15. Development of PWR pressure vessel steels

    International Nuclear Information System (INIS)

    Druce, S.; Edwards, B.

    1982-01-01

    Requirements to be met by vessel steels for pressurized water reactors are analyzed. Chemicat composition of low-alloyed steels, mechanical properties of sheets and forgings made of these steels and changes in the composition and properties over the wall thickness of the reactor vessel are presented. Problems of the vessel manufacturing including welding and heat treatment processes of sheets and forgings are considered. Special attention is paid to steel embrittlement during vessel fabrication and operation (radiation embrittlement, thermal embrittlement). The role of non-metal inclusions and their effect on anisotropy of fracture toughness is discussed. Possible developments of vessel steels and procedures for producing reactor vessels are reviewed

  16. Development of PWR pressure vessel steels

    Energy Technology Data Exchange (ETDEWEB)

    Druce, S.; Edwards, B.

    1982-01-01

    Requirements to be met by vessel steels for pressurized water reactors are analyzed. Chemicat composition of low-alloyed steels, mechanical properties of sheets and forgings made of these steels and changes in the composition and properties over the wall thickness of the reactor vessel are presented. Problems of the vessel manufacturing including welding and heat treatment processes of sheets and forgings are considered. Special attention is paid to steel embrittlement during vessel fabrication and operation (radiation embrittlement, thermal embrittlement). The role of non-metal inclusions and their effect on anisotropy of fracture toughness is discussed. Possible developments of vessel steels and procedures for producing reactor vessels are reviewed.

  17. Novel 3D ultrasound image-based biomarkers based on a feature selection from a 2D standardized vessel wall thickness map: a tool for sensitive assessment of therapies for carotid atherosclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Chiu, Bernard; Bing, Li; Chow, Tommy W S, E-mail: bcychiu@cityu.edu.hk, E-mail: bingli5@student.cityu.edu.hk, E-mail: eetchow@cityu.edu.hk [Department of Electronic Engineering, City University of Hong Kong (Hong Kong)

    2013-09-07

    With the advent of new therapies and management strategies for carotid atherosclerosis, there is a parallel need for measurement tools or biomarkers to evaluate the efficacy of these new strategies. 3D ultrasound has been shown to provide reproducible measurements of plaque area/volume and vessel wall volume. However, since carotid atherosclerosis is a focal disease that predominantly occurs at bifurcations, biomarkers based on local plaque change may be more sensitive than global volumetric measurements in demonstrating efficacy of new therapies. The ultimate goal of this paper is to develop a biomarker that is based on the local distribution of vessel-wall-plus-plaque thickness change (VWT-Change) that has occurred during the course of a clinical study. To allow comparison between different treatment groups, the VWT-Change distribution of each subject must first be mapped to a standardized domain. In this study, we developed a technique to map the 3D VWT-Change distribution to a 2D standardized template. We then applied a feature selection technique to identify regions on the 2D standardized map on which subjects in different treatment groups exhibit greater difference in VWT-Change. The proposed algorithm was applied to analyse the VWT-Change of 20 subjects in a placebo-controlled study of the effect of atorvastatin (Lipitor). The average VWT-Change for each subject was computed (i) over all points in the 2D map and (ii) over feature points only. For the average computed over all points, 97 subjects per group would be required to detect an effect size of 25% that of atorvastatin in a six-month study. The sample size is reduced to 25 subjects if the average were computed over feature points only. The introduction of this sensitive quantification technique for carotid atherosclerosis progression/regression would allow many proof-of-principle studies to be performed before a more costly and longer study involving a larger population is held to confirm the treatment

  18. Novel 3D ultrasound image-based biomarkers based on a feature selection from a 2D standardized vessel wall thickness map: a tool for sensitive assessment of therapies for carotid atherosclerosis

    International Nuclear Information System (INIS)

    Chiu, Bernard; Li Bing; Chow, Tommy W S

    2013-01-01

    With the advent of new therapies and management strategies for carotid atherosclerosis, there is a parallel need for measurement tools or biomarkers to evaluate the efficacy of these new strategies. 3D ultrasound has been shown to provide reproducible measurements of plaque area/volume and vessel wall volume. However, since carotid atherosclerosis is a focal disease that predominantly occurs at bifurcations, biomarkers based on local plaque change may be more sensitive than global volumetric measurements in demonstrating efficacy of new therapies. The ultimate goal of this paper is to develop a biomarker that is based on the local distribution of vessel-wall-plus-plaque thickness change (VWT-Change) that has occurred during the course of a clinical study. To allow comparison between different treatment groups, the VWT-Change distribution of each subject must first be mapped to a standardized domain. In this study, we developed a technique to map the 3D VWT-Change distribution to a 2D standardized template. We then applied a feature selection technique to identify regions on the 2D standardized map on which subjects in different treatment groups exhibit greater difference in VWT-Change. The proposed algorithm was applied to analyse the VWT-Change of 20 subjects in a placebo-controlled study of the effect of atorvastatin (Lipitor). The average VWT-Change for each subject was computed (i) over all points in the 2D map and (ii) over feature points only. For the average computed over all points, 97 subjects per group would be required to detect an effect size of 25% that of atorvastatin in a six-month study. The sample size is reduced to 25 subjects if the average were computed over feature points only. The introduction of this sensitive quantification technique for carotid atherosclerosis progression/regression would allow many proof-of-principle studies to be performed before a more costly and longer study involving a larger population is held to confirm the treatment

  19. Wall Shear Rates in Taylor Vortex Flow

    Czech Academy of Sciences Publication Activity Database

    Sobolík, V.; Jirout, T.; Havlica, Jaromír; Kristiawan, M.

    2011-01-01

    Roč. 4, č. 3 (2011), s. 25-31 ISSN 1735-3572 Grant - others:ANR:(FR) ANR-08-BLAN-0184-01 Institutional research plan: CEZ:AV0Z40720504 Keywords : taylor-couette flow * electrodiffusion diagnostics * membrane reactors Subject RIV: CI - Industrial Chemistry, Chemical Engineering http://www.jafmonline.net/modules/journal/journal_browse.php?EJjid=13

  20. Nuclear reactor construction with bottom supported reactor vessel

    International Nuclear Information System (INIS)

    Sharbaugh, J.E.

    1987-01-01

    This patent describes an improved liquid metal nuclear reactor construction comprising: (a) a nuclear reactor core having a bottom platform support structure; (b) a reactor vessel for holding a large pool of low pressure liquid metal coolant and housing the core; (c) a containment structure surrounding the reactor vessel and having a sidewall spaced outwardly from the reactor vessel side wall and having a base mat spaced below the reactor vessel bottom end wall; (d) a central small diameter post anchored to the containment structure base mat and extending upwardly to the reactor vessel to axially fix the bottom end wall of the reactor vessel and provide a center column support for the lower end of the reactor core; (e) annular support structure disposed in the reactor vessel on the bottom end wall and extending about the lower end of the core; (f) structural support means disposed between the containment structure base mat and bottom end of the reactor vessel wall and cooperating for supporting the reactor vessel at its bottom end wall on the containment structure base mat to allow the reactor vessel to expand radially but substantially prevent any lateral motions that might be imposed by the occurrence of a seismic event; (g) a bed of insulating material disposed between the containment structure base mat and the bottom end wall of the reactor vessel and uniformly supporting the reactor vessel at its bottom end wall; freely expand radially from the central post as it heats up while providing continuous support thereof; (h) a deck supported upon the wall of the containment vessel above the top open end of the reactor vessel; and (i) extendible and retractable coupling means extending between the deck and the top open end of the reactor vessel and flexibly and sealably interconnecting the reactor vessel at its top end to the deck

  1. Shear stress-induced mitochondrial biogenesis decreases the release of microparticles from endothelial cells.

    Science.gov (United States)

    Kim, Ji-Seok; Kim, Boa; Lee, Hojun; Thakkar, Sunny; Babbitt, Dianne M; Eguchi, Satoru; Brown, Michael D; Park, Joon-Young

    2015-08-01

    The concept of enhancing structural integrity of mitochondria has emerged as a novel therapeutic option for cardiovascular disease. Flow-induced increase in laminar shear stress is a potent physiological stimulant associated with exercise, which exerts atheroprotective effects in the vasculature. However, the effect of laminar shear stress on mitochondrial remodeling within the vascular endothelium and its related functional consequences remain largely unknown. Using in vitro and in vivo complementary studies, here, we report that aerobic exercise alleviates the release of endothelial microparticles in prehypertensive individuals and that these salutary effects are, in part, mediated by shear stress-induced mitochondrial biogenesis. Circulating levels of total (CD31(+)/CD42a(-)) and activated (CD62E(+)) microparticles released by endothelial cells were significantly decreased (∼40% for both) after a 6-mo supervised aerobic exercise training program in individuals with prehypertension. In cultured human endothelial cells, laminar shear stress reduced the release of endothelial microparticles, which was accompanied by an increase in mitochondrial biogenesis through a sirtuin 1 (SIRT1)-dependent mechanism. Resveratrol, a SIRT1 activator, treatment showed similar effects. SIRT1 knockdown using small-interfering RNA completely abolished the protective effect of shear stress. Disruption of mitochondrial integrity by either antimycin A or peroxisome proliferator-activated receptor-γ coactivator-1α small-interfering RNA significantly increased the number of total, and activated, released endothelial microparticles, and shear stress restored these back to basal levels. Collectively, these data demonstrate a critical role of endothelial mitochondrial integrity in preserving endothelial homeostasis. Moreover, prolonged laminar shear stress, which is systemically elevated during aerobic exercise in the vessel wall, mitigates endothelial dysfunction by promoting

  2. PWR vessel inspection performance improvements

    International Nuclear Information System (INIS)

    Blair Fairbrother, D.; Bodson, Francis

    1998-01-01

    A compact robot for ultrasonic inspection of reactor vessels has been developed that reduces setup logistics and schedule time for mandatory code inspections. Rather than installing a large structure to access the entire weld inspection area from its flange attachment, the compact robot examines welds in overlapping patches from a suction cup anchor to the shell wall. The compact robot size allows two robots to be operated in the vessel simultaneously. This significantly reduces the time required to complete the inspection. Experience to date indicates that time for vessel examinations can be reduced to fewer than four days. (author)

  3. Comparison of elastic--plastic and variable modulus-cracking constitutive models for prestressed concrete reactor vessels

    International Nuclear Information System (INIS)

    Anderson, C.A.; Smith, P.D.

    1978-01-01

    The variable modulus-cracking model is capable of predicting the behavior of reinforced concrete structures (such as the reinforced plate under transverse pressure described previously) well into the range of nonlinear behavior including the prediction of the ultimate load. For unreinforced thick-walled concrete vessels under internal pressure the use of elastic--plastic concrete models in finite element codes enhances the apparent ductility of the vessels in contrast to variable modulus-cracking models that predict nearly instantaneous rupture whenever the tensile strength at the inner wall is exceeded. For unreinforced thick-walled end slabs representative of PCRV heads, the behavior predicted by finite element codes using variable modulus-cracking models is much stiffer in the nonlinear range than that observed experimentally. Although the shear type failures and crack patterns that are observed experimentally are predicted by such concrete models, the ultimate load carrying capacity and vessel-ductility are significantly underestimated. It appears that such models do not adequately model such features as aggregate interlock that could lead to an enhanced vessel reserve strength and ductility

  4. Pressure vessel for nuclear reactors

    International Nuclear Information System (INIS)

    1975-01-01

    The invention ap