WorldWideScience

Sample records for vessel operating regulations

  1. Vessel Operating Units (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains data for vessels that are greater than five net tons and have a current US Coast Guard documentation number. Beginning in1979, the NMFS...

  2. Vessel Operator System

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Operator cards are required for any operator of a charter/party boat and or a commercial vessel (including carrier and processor vessels) issued a vessel permit from...

  3. Assessing Vessel Traffic Service Operator Situation Awareness

    NARCIS (Netherlands)

    Wiersma, J.W.F.

    2010-01-01

    This thesis describes my study of situation awareness assessment of Vessel Traffic Service (VTS) operators. VTS operators are the traffic controllers on the water. They are responsible for a safe and efficient handling of vessel traffic. They monitor traffic, provide information on request and

  4. Great Lakes Research Vessel Operations 1958-2016: OP

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — These data have been collected on various vessel operations on the Great Lakes and select connecting waterways. This vessel operations data set is part of and...

  5. Integrating Multiple Autonomous Underwater Vessels, Surface Vessels and Aircraft into Oceanographic Research Vessel Operations

    Science.gov (United States)

    McGillivary, P. A.; Borges de Sousa, J.; Martins, R.; Rajan, K.

    2012-12-01

    Autonomous platforms are increasingly used as components of Integrated Ocean Observing Systems and oceanographic research cruises. Systems deployed can include gliders or propeller-driven autonomous underwater vessels (AUVs), autonomous surface vessels (ASVs), and unmanned aircraft systems (UAS). Prior field campaigns have demonstrated successful communication, sensor data fusion and visualization for studies using gliders and AUVs. However, additional requirements exist for incorporating ASVs and UASs into ship operations. For these systems to be optimally integrated into research vessel data management and operational planning systems involves addressing three key issues: real-time field data availability, platform coordination, and data archiving for later analysis. A fleet of AUVs, ASVs and UAS deployed from a research vessel is best operated as a system integrated with the ship, provided communications among them can be sustained. For this purpose, Disruptive Tolerant Networking (DTN) software protocols for operation in communication-challenged environments help ensure reliable high-bandwidth communications. Additionally, system components need to have considerable onboard autonomy, namely adaptive sampling capabilities using their own onboard sensor data stream analysis. We discuss Oceanographic Decision Support System (ODSS) software currently used for situational awareness and planning onshore, and in the near future event detection and response will be coordinated among multiple vehicles. Results from recent field studies from oceanographic research vessels using AUVs, ASVs and UAS, including the Rapid Environmental Picture (REP-12) cruise, are presented describing methods and results for use of multi-vehicle communication and deliberative control networks, adaptive sampling with single and multiple platforms, issues relating to data management and archiving, and finally challenges that remain in addressing these technological issues. Significantly, the

  6. 46 CFR 175.118 - Vessels operating under an exemption afforded in the Passenger Vessel Safety Act of 1993 (PVSA).

    Science.gov (United States)

    2010-10-01

    ... certified for passenger service. If the Certificate of Inspection (COI) is surrendered or otherwise becomes... recertification), the owner or operator must meet the appropriate inspection regulations to obtain a new COI... inspection and may issue a COI if the vessel meets these requirements. The COI's condition of operation must...

  7. Great Lakes Research Vessel Operations 1958-2016

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Great Lakes Research Vessel Operations data release is taken from the Research Vessel Catch (RVCAT) database curated at the Great Lakes Science Center (GLSC)....

  8. Great Lakes Research Vessel Operations 1958-2016: Trawl

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — All trawl data represented here expand upon vessel operations (OP table) data, all of which are collected by the United States Geological Survey, Great Lakes Science...

  9. Great Lakes Research Vessel Operations 1958-2016: Mysis

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — All mysis data represented here expand upon vessel operations (OP table) data, all of which are collected by the United States Geological Survey, Great Lakes Science...

  10. Great Lakes Research Vessel Operations 1958-2016: Mensuration

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — All mensuration data represented here expand upon vessel operations (OP table) data, all of which are collected by the United States Geological Survey, Great Lakes...

  11. Great Lakes Research Vessel Operations 1958-2016: Gillnet

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — All gillnet data represented here expand upon vessel operations (OP table) data, all of which are collected by the United States Geological Survey, Great Lakes...

  12. Great Lakes Research Vessel Operations 1958-2016: Reference

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The RVCAT database contains data that have been collected on various vessel operations on the Great Lakes and select connecting waterways. This section of Reference...

  13. Great Lakes Research Vessel Operations 1958-2016: Benthos Ponar

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — All benthos data represented here expand upon vessel operations (OP table) data, all of which are collected by the United States Geological Survey, Great Lakes...

  14. 78 FR 40891 - Revisions to the Export Administration Regulations: Military Vehicles; Vessels of War...

    Science.gov (United States)

    2013-07-08

    ..., et al. Revisions to the Export Administration Regulations: Military Vehicles; Vessels of War... the Export Administration Regulations: Military Vehicles; Vessels of War; Submersible Vessels..., Department of Commerce. ACTION: Final rule. SUMMARY: This rule adds to the Export Administration Regulations...

  15. Marine Vessel Models in Changing Operational Conditions - A Tutorial

    DEFF Research Database (Denmark)

    Perez, Tristan; Sørensen, Asgeir; Blanke, Mogens

    2006-01-01

    This tutorial paper provides an introduction, from a systems perspective, to the topic of ship motion dynamics of surface ships. It presents a classification of parametric models currently used for monitoring and control of marine vessels. These models are valid for certain vessel operational...... conditions (VOC). However, since marine systems operate in changing VOCs, there is a need to adapt the models. To date, there is no theory available to describe a general model valid across different VOCs due to the complexity of the hydrodynamic involved. It is believed that system identification could...

  16. Lymphatic vessels regulate immune microenvironments in human and murine melanoma.

    Science.gov (United States)

    Lund, Amanda W; Wagner, Marek; Fankhauser, Manuel; Steinskog, Eli S; Broggi, Maria A; Spranger, Stefani; Gajewski, Thomas F; Alitalo, Kari; Eikesdal, Hans P; Wiig, Helge; Swartz, Melody A

    2016-09-01

    Lymphatic remodeling in tumor microenvironments correlates with progression and metastasis, and local lymphatic vessels play complex and poorly understood roles in tumor immunity. Tumor lymphangiogenesis is associated with increased immune suppression, yet lymphatic vessels are required for fluid drainage and immune cell trafficking to lymph nodes, where adaptive immune responses are mounted. Here, we examined the contribution of lymphatic drainage to tumor inflammation and immunity using a mouse model that lacks dermal lymphatic vessels (K14-VEGFR3-Ig mice). Melanomas implanted in these mice grew robustly, but exhibited drastically reduced cytokine expression and leukocyte infiltration compared with those implanted in control animals. In the absence of local immune suppression, transferred cytotoxic T cells more effectively controlled tumors in K14-VEGFR3-Ig mice than in control mice. Furthermore, gene expression analysis of human melanoma samples revealed that patient immune parameters are markedly stratified by levels of lymphatic markers. This work suggests that the establishment of tumor-associated inflammation and immunity critically depends on lymphatic vessel remodeling and drainage. Moreover, these results have implications for immunotherapies, the efficacies of which are regulated by the tumor immune microenvironment.

  17. 46 CFR 117.206 - Survival craft-vessels operating on Great Lakes routes.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Survival craft-vessels operating on Great Lakes routes...—vessels operating on Great Lakes routes. (a) Except as allowed by paragraph (b) of this section, each vessel certificated to operate on a Great Lakes route must be provided with the survival craft required...

  18. 46 CFR 180.206 - Survival craft-vessels operating on Great Lakes routes.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Survival craft-vessels operating on Great Lakes routes... Craft § 180.206 Survival craft—vessels operating on Great Lakes routes. (a) Except as allowed by paragraph (b) of this section, each vessel certificated to operate on a Great Lakes route must be provided...

  19. 46 CFR 180.202 - Survival craft-vessels operating on oceans routes.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Survival craft-vessels operating on oceans routes. 180... § 180.202 Survival craft—vessels operating on oceans routes. (a) Each vessel certificated to operate on an oceans route in cold water must either: (1) Be provided with inflatable buoyant apparatus of an...

  20. 46 CFR 50.05-15 - Vessels subject to regulations in this subchapter.

    Science.gov (United States)

    2010-10-01

    ...-15 Section 50.05-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING GENERAL PROVISIONS Application § 50.05-15 Vessels subject to regulations in this subchapter. (a) Passenger vessels, tank vessels, cargo and miscellaneous vessels, nautical schoolships, mobile offshore...

  1. 77 FR 62247 - Dynamic Positioning Operations Guidance for Vessels Other Than Mobile Offshore Drilling Units...

    Science.gov (United States)

    2012-10-12

    ...] Dynamic Positioning Operations Guidance for Vessels Other Than Mobile Offshore Drilling Units Operating on... voluntary guidance titled ``Mobile Offshore Drilling Unit Dynamic Positioning Guidance''. The notice recommended owners and operators of Mobile Offshore Drilling Units (MODUs) follow Marine Technology Society...

  2. 33 CFR 150.380 - Under what circumstances may vessels operate within the safety zone or area to be avoided?

    Science.gov (United States)

    2010-07-01

    ... N F C F Fishing, including bottom trawl (shrimping) N D P N Mobile drilling operations or erection...: OPERATIONS Vessel Navigation § 150.380 Under what circumstances may vessels operate within the safety zone or...—Movement of the vessel is permitted when cleared by the person in charge of vessel operations. D—Movement...

  3. 46 CFR 117.202 - Survival craft-vessels operating on oceans routes.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Survival craft-vessels operating on oceans routes. 117... operating on oceans routes. (a) Except as allowed by paragraph (b) of this section, each vessel certificated to operate on an oceans route in cold water must be provided with inflatable liferafts of an...

  4. Active cooling system for Tokamak in-vessel operation manipulator

    Energy Technology Data Exchange (ETDEWEB)

    Yuan, Jianjun, E-mail: yuanjj@sjtu.edu.cn; Chen, Tan; Li, Fashe; Zhang, Weijun; Du, Liang

    2015-10-15

    Highlights: • We summarized most of the challenges of fusion devices to robot systems. • Propose an active cooling system to protect all of the necessary components. • Trial design test and theoretical analysis were conducted. • Overall implementation of the active cooling system was demonstrated. - Abstract: In-vessel operation/inspection is an indispensable task for Tokamak experimental reactor, for a robot/manipulator is more capable in doing this than human being with more precise motion and less risk of damaging the ambient equipment. Considering the demanding conditions of Tokamak, the manipulator should be adaptable to rapid response in the extreme conditions such as high temperature, vacuum and so on. In this paper, we propose an active cooling system embedded into such manipulator. Cameras, motors, gearboxes, sensors, and other mechanical/electrical components could then be designed under ordinary conditions. The cooling system cannot only be a thermal shield since the components are also heat sources in dynamics. We carry out a trial test to verify our proposal, and analyze the active cooling system theoretically, which gives a direction on the optimization by varying design parameters, components and distribution. And based on thermal sensors monitoring and water flow adjusting a closed-loop feedback control of temperature is added to the system. With the preliminary results, we believe that the proposal gives a way to robust and inexpensive design in extreme environment. Further work will concentrate on overall implementation and evaluation of this cooling system with the whole inspection manipulator.

  5. Rapid Operational Access and Maneuver Support (ROAMS) Platform for Improved Military Logistics Lines of Communication and Operational Vessel Routing

    Science.gov (United States)

    2017-06-01

    Platform for Improved Military Logistics Lines of Communication and Operational Vessel Routing by Drew Loney, Kimberly Pevey, Jennifer McAlpin...provides improved knowledge of potential lines of communication and vessel routes through hydrodynamic modeling and path optimization under a variety of...classified into two types of activities: logistics and operational. Logistics activities are concerned with the establishment of lines of communication

  6. Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels.

    Science.gov (United States)

    Sperandio, Markus; Quackenbush, Elizabeth J; Sushkova, Natalia; Altstätter, Johannes; Nussbaum, Claudia; Schmid, Stephan; Pruenster, Monika; Kurz, Angela; Margraf, Andreas; Steppner, Alina; Schweiger, Natalie; Borsig, Lubor; Boros, Ildiko; Krajewski, Nele; Genzel-Boroviczeny, Orsolya; Jeschke, Udo; Frommhold, David; von Andrian, Ulrich H

    2013-05-23

    In adult mammals, leukocyte recruitment follows a well-defined cascade of adhesion events enabling leukocytes to leave the circulatory system and transmigrate into tissue. Currently, it is unclear whether leukocyte recruitment proceeds in a similar fashion during fetal development. Considering the fact that the incidence of neonatal sepsis increases dramatically with decreasing gestational age in humans, we hypothesized that leukocyte recruitment may be acquired only late during fetal ontogeny. To test this, we developed a fetal intravital microscopy model in pregnant mice and, using LysEGFP (neutrophil reporter) mice, investigated leukocyte recruitment during fetal development. We show that fetal blood neutrophils acquire the ability to roll and adhere on inflamed yolk sac vessels during late fetal development, whereas at earlier embryonic stages (before day E15), rolling and adhesion were essentially absent. Accordingly, flow chamber experiments showed that fetal EGFP(+) blood cells underwent efficient adhesion only when they were harvested on or after E15. Fluorescence-activated cell sorter analysis on EGFP(+) fetal blood cells revealed that surface expression of CXCR2 and less pronounced P-selectin glycoprotein ligand-1 (PSGL-1) begin to increase only late in fetal life. Taken together, our findings demonstrate that inflammation-induced leukocyte recruitment is ontogenetically regulated and enables efficient neutrophil trafficking only during late fetal life.

  7. 78 FR 61223 - Regulated Navigation Area; Southern Oahu Tsunami Vessel Evacuation, Honolulu, HI

    Science.gov (United States)

    2013-10-03

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Regulated Navigation Area; Southern Oahu Tsunami Vessel... evacuation of Southern Oahu ports. DATES: Comments and related material must be received by the Coast Guard... Southern Oahu Tsunami Vessel Evacuation regulated navigation area. All recommendations received careful...

  8. Scenario based optimization of a container vessel with respect to its projected operating conditions

    OpenAIRE

    Wagner Jonas; Binkowski Eva; Bronsart Robert

    2014-01-01

    In this paper the scenario based optimization of the bulbous bow of the KRISO Container Ship (KCS) is presented. The optimization of the parametrically modeled vessel is based on a statistically developed operational profile generated from noon-to-noon reports of a comparable 3600 TEU container vessel and specific development functions representing the growth of global economy during the vessels service time. In order to consider uncertainties, statistical fluctuations are added. An analysis ...

  9. Operational model for vessel traffic using optimal control and calibration

    NARCIS (Netherlands)

    Shu, Y.; Daamen, W.; Ligteringen, H.; Hoogendoorn, S.P.

    2015-01-01

    Due to the ever-increasing economic globalization, the scale of transportation through ports and waterways has increased sharply. As the capacity of maritime infrastructure in ports and inland waterways is limited, it is important to simulate vessel behavior to balance safety and capacity in

  10. 33 CFR 160.113 - Prohibition of vessel operation and cargo transfers.

    Science.gov (United States)

    2010-07-01

    ... does not pose a threat to the marine environment, and that such entry is necessary for the safety of..., or serious repair problems creates reason to believe that the vessel may be unsafe or pose a threat to the marine environment. (b) The authority to issue orders prohibiting operation of the vessels or...

  11. [Simple analysis on professor ZHANG Dao-Zong's academic thought of dredging the Governor Vessel and regulating mentality].

    Science.gov (United States)

    Cao, Yi; Li, Pei-Fang; Chen, Xing-Sheng

    2006-10-01

    Introduce Professor Zhang Dao-zong's studies on the Governor Vessel and its academic thought of dredging the Governor Vessel and regulating mentality, and clinical experiences of dredging the Governor Vessel and regulating mentality therapy for apoplexy, epilepsy, vertigo, ankynosing spondylitis, traumatic paraplegia, child Tourette's disease, etc....

  12. Lifting simulation of an offshore supply vessel considering various operating conditions

    Directory of Open Access Journals (Sweden)

    Dong-Hoon Jeong

    2016-06-01

    Full Text Available Recently, an offshore support vessel is being widely used to install an offshore structure such as a subsea equipment which is laid on its deck. The lifting operation which is one of the installation operations includes lifting off, lifting in the air, splash zone crossing, deep submerging, and finally landing of the structure with an offshore support vessel crane. There are some major considerations during this operation. Especially, when lifting off the structure, if operating conditions such as ocean environmental loads and hoisting (or lowering speed are bad, the excess of tension of wire ropes of the crane and the collision between the offshore support vessel and the structure can be occurred due to the relative motion between them. To solve this problem, this study performs the lifting simulation while the offshore support vessel installs the structure. The simulation includes the calculation of dynamic responses of the offshore support vessel and the equipment, including the wire tension and the collision detection. To check the applicability of the simulation, it is applied to some lifting steps by varying operating conditions. As a result, it is confirmed that the conditions affect the operability of those steps.

  13. Regulation of coronary resistance vessel tone in response to exercise.

    Science.gov (United States)

    Duncker, Dirk J; Bache, Robert J; Merkus, Daphne

    2012-04-01

    Exercise is a primary stimulus for increased myocardial oxygen demand. The ~6-fold increase in oxygen demand of the left ventricle during heavy exercise is met principally by augmenting coronary blood flow (~5-fold), as hemoglobin concentration and oxygen extraction (which is already ~70% at rest) increase only modestly in most species. As a result, coronary blood flow is tightly coupled to myocardial oxygen consumption over a wide range of physical activity. This tight coupling has been proposed to depend on periarteriolar oxygen tension, signals released from cardiomyocytes and the endothelium as well as neurohumoral influences, but the contribution of each of these regulatory pathways, and their interactions, to exercise hyperemia in the heart remain incompletely understood. In humans, nitric oxide, adenosine and K(ATP) channels each appear to contribute to resting coronary resistance vessel tone, but evidence for a critical contribution to exercise hyperemia is lacking. In dogs K(ATP)-channel activation together with adenosine and nitric oxide contribute to exercise hyperemia in a non-linear redundant fashion. In contrast, in swine nitric oxide, adenosine and K(ATP) channels contribute to resting coronary resistance vessel tone control in a linear additive manner, but do not appear to be mandatory for exercise hyperemia. Rather, exercise hyperemia in swine appears to involve β-adrenergic activation in conjunction with exercise-induced blunting of an endothelin-mediated vasoconstrictor influence. In view of these remarkable species differences in coronary vasomotor control during exercise, future studies are required to determine the system of vasodilator components that mediate exercise hyperemia in humans. This article is part of a Special Issue entitled "Coronary Blood Flow". Copyright © 2011 Elsevier Ltd. All rights reserved.

  14. Cathepsin B-mediated CD18 shedding regulates leukocyte recruitment from angiogenic vessels.

    Science.gov (United States)

    Nakao, Shintaro; Zandi, Souska; Sun, Dawei; Hafezi-Moghadam, Ali

    2018-01-01

    Cathepsin B (CtsB) contributes to atherosclerosis and cancer progression by processing the extracellular matrix and promoting angiogenesis. Although CtsB was reported to promote and reduce angiogenesis, there is no mechanistic explanation that reconciles this apparent discrepancy. CtsB cleaves CD18 from the surface of immune cells, but its contribution to angiogenesis has not been studied. We developed an in vivo technique for visualization of immune cell transmigration from corneal vessels toward implanted cytokines. Wild-type (WT) leukocytes extravasated from limbal vessels, angiogenic stalks, and growing tip vessels and migrated toward the cytokines, indicating immune competence of angiogenic vessels. Compared to WT leukocytes, CtsB-/- leukocytes accumulated in a higher number in angiogenic vessels, but extravasated less toward the implanted cytokine. The accumulated CtsB-/- leukocytes in angiogenic vessels expressed more CD18. CD18-/- leukocytes extravasated later than WT leukocytes. However, once extravasated, CD18-/- leukocytes transmigrated more rapidly than their WT counterparts. These results suggest that, although CD18 facilitates efficient extravasation, outside of the vessel CD18 interaction with the extracellular matrix, it reduced transmigration velocity. Our results reveal an unexpected role for CtsB in leukocyte extravasation and transmigration, which advances our understanding of the complex contribution of CtsB to angiogenesis.-Nakao, S., Zandi, S., Sun, D., Hafezi-Moghadam, A. Cathepsin B-mediated CD18 shedding regulates leukocyte recruitment from angiogenic vessels. © FASEB.

  15. The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density

    Science.gov (United States)

    Lee, Kit M; Danuser, Renzo; Stein, Jens V; Graham, Delyth; Nibbs, Robert JB; Graham, Gerard J

    2014-01-01

    Macrophages regulate lymphatic vasculature development; however, the molecular mechanisms regulating their recruitment to developing, and adult, lymphatic vascular sites are not known. Here, we report that resting mice deficient for the inflammatory chemokine-scavenging receptor, ACKR2, display increased lymphatic vessel density in a range of tissues under resting and regenerating conditions. This appears not to alter dendritic cell migration to draining lymph nodes but is associated with enhanced fluid drainage from peripheral tissues and thus with a hypotensive phenotype. Examination of embryonic skin revealed that this lymphatic vessel density phenotype is developmentally established. Further studies indicated that macrophages and the inflammatory CC-chemokine CCL2, which is scavenged by ACKR2, are associated with this phenotype. Accordingly, mice deficient for the CCL2 signalling receptor, CCR2, displayed a reciprocal phenotype of reduced lymphatic vessel density. Further examination revealed that proximity of pro-lymphangiogenic macrophages to developing lymphatic vessel surfaces is increased in ACKR2-deficient mice and reduced in CCR2-deficient mice. Therefore, these receptors regulate vessel density by reciprocally modulating pro-lymphangiogenic macrophage recruitment, and proximity, to developing, resting and regenerating lymphatic vessels. PMID:25271254

  16. Smooth muscle–endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation

    Science.gov (United States)

    Lutter, Sophie; Xie, Sherry; Tatin, Florence

    2012-01-01

    Active lymph transport relies on smooth muscle cell (SMC) contractions around collecting lymphatic vessels, yet regulation of lymphatic vessel wall assembly and lymphatic pumping are poorly understood. Here, we identify Reelin, an extracellular matrix glycoprotein previously implicated in central nervous system development, as an important regulator of lymphatic vascular development. Reelin-deficient mice showed abnormal collecting lymphatic vessels, characterized by a reduced number of SMCs, abnormal expression of lymphatic capillary marker lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), and impaired function. Furthermore, we show that SMC recruitment to lymphatic vessels stimulated release and proteolytic processing of endothelium-derived Reelin. Lymphatic endothelial cells in turn responded to Reelin by up-regulating monocyte chemotactic protein 1 (MCP1) expression, which suggests an autocrine mechanism for Reelin-mediated control of endothelial factor expression upstream of SMC recruitment. These results uncover a mechanism by which Reelin signaling is activated by communication between the two cell types of the collecting lymphatic vessels—smooth muscle and endothelial cells—and highlight a hitherto unrecognized and important function for SMCs in lymphatic vessel morphogenesis and function. PMID:22665518

  17. The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density.

    Science.gov (United States)

    Lee, Kit M; Danuser, Renzo; Stein, Jens V; Graham, Delyth; Nibbs, Robert J B; Graham, Gerard J

    2014-11-03

    Macrophages regulate lymphatic vasculature development; however, the molecular mechanisms regulating their recruitment to developing, and adult, lymphatic vascular sites are not known. Here, we report that resting mice deficient for the inflammatory chemokine-scavenging receptor, ACKR2, display increased lymphatic vessel density in a range of tissues under resting and regenerating conditions. This appears not to alter dendritic cell migration to draining lymph nodes but is associated with enhanced fluid drainage from peripheral tissues and thus with a hypotensive phenotype. Examination of embryonic skin revealed that this lymphatic vessel density phenotype is developmentally established. Further studies indicated that macrophages and the inflammatory CC-chemokine CCL2, which is scavenged by ACKR2, are associated with this phenotype. Accordingly, mice deficient for the CCL2 signalling receptor, CCR2, displayed a reciprocal phenotype of reduced lymphatic vessel density. Further examination revealed that proximity of pro-lymphangiogenic macrophages to developing lymphatic vessel surfaces is increased in ACKR2-deficient mice and reduced in CCR2-deficient mice. Therefore, these receptors regulate vessel density by reciprocally modulating pro-lymphangiogenic macrophage recruitment, and proximity, to developing, resting and regenerating lymphatic vessels. © 2014 The Authors. Published under the terms of the CC BY 4.0 license.

  18. Scenario based optimization of a container vessel with respect to its projected operating conditions

    Directory of Open Access Journals (Sweden)

    Jonas Wagner

    2014-06-01

    Full Text Available In this paper the scenario based optimization of the bulbous bow of the KRISO Container Ship (KCS is presented. The optimization of the parametrically modeled vessel is based on a statistically developed operational profile generated from noon-to-noon reports of a comparable 3600 TEU container vessel and specific development functions representing the growth of global economy during the vessels service time. In order to consider uncertainties, statistical fluctuations are added. An analysis of these data lead to a number of most probable upcoming operating conditions (OC the vessel will stay in the future. According to their respective likeliness an objective function for the evaluation of the optimal design variant of the vessel is derived and implemented within the parametrical optimization workbench FRIENDSHIP Framework. In the following this evaluation is done with respect to vessel's calculated effective power based on the usage of potential flow code. The evaluation shows, that the usage of scenarios within the optimization process has a strong influence on the hull form.

  19. The French Space Operation Act: Technical Regulations

    Science.gov (United States)

    Trinchero, J. P.; Lazare, B.

    2010-09-01

    The French Space Operation Act(FSOA) stipulates that a prime objective of the National technical regulations is to protect people, property, public health and the environment. Compliance with these technical regulations is mandatory as of 10 December 2010 for space operations by French space operators and for space operations from French territory. The space safety requirements and regulations governing procedures are based on national and international best practices and experience. A critical design review of the space system and procedures shall be carried out by the applicant, in order to verify compliance with the Technical Regulations. An independent technical assessment of the operation is delegated to CNES. The principles applied when drafting technical regulations are as follows: requirements must as far as possible establish the rules according to the objective to be obtained, rather than how it is to be achieved; requirements must give preference to international standards recognised as being the state of the art; requirements must take previous experience into account. Technical regulations are divided into three sections covering common requirements for the launch, control and return of a space object. A dedicated section will cover specific rules to be applied at the Guiana Space Centre. The main topics addressed by the technical regulations are: operator safety management system; study of risks to people, property, public health and the Earth’s environment; impact study on the outer space environment: space debris generated by the operation; planetary protection.

  20. 36 CFR 3.6 - What are the requirements to operate a power driven vessel?

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false What are the requirements to operate a power driven vessel? 3.6 Section 3.6 Parks, Forests, and Public Property NATIONAL PARK SERVICE... is located within a State having a mandatory boater education requirement, then that State...

  1. Scenario based optimization of a container vessel with respect to its projected operating conditions

    Directory of Open Access Journals (Sweden)

    Wagner Jonas

    2014-06-01

    Full Text Available In this paper the scenario based optimization of the bulbous bow of the KRISO Container Ship (KCS is presented. The optimization of the parametrically modeled vessel is based on a statistically developed operational profile generated from noon-to-noon reports of a comparable 3600 TEU container vessel and specific development functions representing the growth of global economy during the vessels service time. In order to consider uncertainties, statistical fluctuations are added. An analysis of these data lead to a number of most probable upcoming operating conditions (OC the vessel will stay in the future. According to their respective likeliness an objective function for the evaluation of the optimal design variant of the vessel is derived and implemented within the parametrical optimization workbench FRIENDSHIP Framework. In the following this evaluation is done with respect to vessel’s calculated effective power based on the usage of potential flow code. The evaluation shows, that the usage of scenarios within the optimization process has a strong influence on the hull form.

  2. The French Space Operations Act: Technical Regulations

    Science.gov (United States)

    Lazare, B.

    2013-12-01

    The French Space Operations Act (FSOA) [1] stipulates that one of the National Technical Regulations' prime objectives is to protect people, property, public health and the environment. Compliance with these Technical Regulations has been mandatory since 10 December, 2010 for space operations by French space operators and for space operations conducted on French territory. The space safety requirements and regulations governing procedures are based on national and international best practices and experience. A critical design review of the space system and procedures shall be carried out by applicant space operators, in order to verify compliance with the Technical Regulations. An independent technical assessment of the operation is delegated to CNES. The principles applied when drafting the Technical Regulations are as follows: requirements must, as far as possible, establish the rules according to the objective to be obtained, rather than how it is to be achieved; requirements must give preference to international standards recognised as being state of the art; requirements must take previous experience into account. The Technical Regulations are divided into three sections covering requirements common to the launch, control and return of a space object. A special section will cover specific rules to be applied at the Guiana Space Centre. The main topics addressed by the Technical Regulations are: operator safety management system; study of risks to people, property, public health and the Earth's environment; impact study on the outer space environment: space debris generated by the operation; planetary protection. The first version of the Technical Regulations [2], issued in March 2011, is dedicated to unmanned space systems.

  3. 78 FR 28170 - Regulated Navigation Area; Southern Oahu Tsunami Vessel Evacuation; Honolulu, HI

    Science.gov (United States)

    2013-05-14

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA11 Regulated Navigation Area; Southern Oahu Tsunami Vessel... Southern Oahu ports. DATES: Comments and related material must be received by the Coast Guard on or before... and organized evacuation plan, in order to protect the infrastructure of the southern coast of Oahu...

  4. 50 CFR 216.46 - U.S. citizens on foreign flag vessels operating under the International Dolphin Conservation...

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false U.S. citizens on foreign flag vessels operating under the International Dolphin Conservation Program. 216.46 Section 216.46 Wildlife and Fisheries....46 U.S. citizens on foreign flag vessels operating under the International Dolphin Conservation...

  5. Combining operational models and data into a dynamic vessel risk assessment tool for coastal regions

    Science.gov (United States)

    Fernandes, R.; Braunschweig, F.; Lourenço, F.; Neves, R.

    2016-02-01

    The technological evolution in terms of computational capacity, data acquisition systems, numerical modelling and operational oceanography is supplying opportunities for designing and building holistic approaches and complex tools for newer and more efficient management (planning, prevention and response) of coastal water pollution risk events. A combined methodology to dynamically estimate time and space variable individual vessel accident risk levels and shoreline contamination risk from ships has been developed, integrating numerical metocean forecasts and oil spill simulations with vessel tracking automatic identification systems (AIS). The risk rating combines the likelihood of an oil spill occurring from a vessel navigating in a study area - the Portuguese continental shelf - with the assessed consequences to the shoreline. The spill likelihood is based on dynamic marine weather conditions and statistical information from previous accidents. The shoreline consequences reflect the virtual spilled oil amount reaching shoreline and its environmental and socio-economic vulnerabilities. The oil reaching shoreline is quantified with an oil spill fate and behaviour model running multiple virtual spills from vessels along time, or as an alternative, a correction factor based on vessel distance from coast. Shoreline risks can be computed in real time or from previously obtained data. Results show the ability of the proposed methodology to estimate the risk properly sensitive to dynamic metocean conditions and to oil transport behaviour. The integration of meteo-oceanic + oil spill models with coastal vulnerability and AIS data in the quantification of risk enhances the maritime situational awareness and the decision support model, providing a more realistic approach in the assessment of shoreline impacts. The risk assessment from historical data can help finding typical risk patterns ("hot spots") or developing sensitivity analysis to specific conditions, whereas real

  6. Protein S-Nitrosylation Regulates Xylem Vessel Cell Differentiation in Arabidopsis.

    Science.gov (United States)

    Kawabe, Harunori; Ohtani, Misato; Kurata, Tetsuya; Sakamoto, Tomoaki; Demura, Taku

    2018-01-01

    Post-translational modifications of proteins have important roles in the regulation of protein activity. One such modification, S-nitrosylation, involves the covalent binding of nitric oxide (NO)-related species to a cysteine residue. Recent work showed that protein S-nitrosylation has crucial functions in plant development and environmental responses. In the present study, we investigated the importance of protein S-nitrosylation for xylem vessel cell differentiation using a forward genetics approach. We performed ethyl methanesulfonate mutagenesis of a transgenic Arabidopsis 35S::VND7-VP16-GR line in which the activity of VASCULAR-RELATED NAC-DOMAIN7 (VND7), a key transcription factor involved in xylem vessel cell differentiation, can be induced post-translationally by glucocorticoid treatment, with the goal of obtaining suppressor mutants that failed to differentiate ectopic xylem vessel cells; we named these mutants suppressor of ectopic vessel cell differentiation induced by VND7 (seiv) mutants. We found the seiv1 mutant to be a recessive mutant in which ectopic xylem cell differentiation was inhibited, especially in aboveground organs. In seiv1 mutants, a single nucleic acid substitution (G to A) leading to an amino acid substitution (E36K) was present in the gene encoding S-NITROSOGLUTATHIONE REDUCTASE 1 (GSNOR1), which regulates the turnover of the natural NO donor, S-nitrosoglutathione. An in vitro S-nitrosylation assay revealed that VND7 can be S-nitrosylated at Cys264 and Cys320 located near the transactivation activity-related domains, which were shown to be important for transactivation activity of VND7 by transient reporter assay. Our results suggest crucial roles for GSNOR1-regulated protein S-nitrosylation in xylem vessel cell differentiation, partly through the post-translational modification of VND7. © The Author 2017. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions

  7. Pressure vessel design manual

    CERN Document Server

    Moss, Dennis R

    2013-01-01

    Pressure vessels are closed containers designed to hold gases or liquids at a pressure substantially different from the ambient pressure. They have a variety of applications in industry, including in oil refineries, nuclear reactors, vehicle airbrake reservoirs, and more. The pressure differential with such vessels is dangerous, and due to the risk of accident and fatality around their use, the design, manufacture, operation and inspection of pressure vessels is regulated by engineering authorities and guided by legal codes and standards. Pressure Vessel Design Manual is a solutions-focused guide to the many problems and technical challenges involved in the design of pressure vessels to match stringent standards and codes. It brings together otherwise scattered information and explanations into one easy-to-use resource to minimize research and take readers from problem to solution in the most direct manner possible. * Covers almost all problems that a working pressure vessel designer can expect to face, with ...

  8. [Efficacy comparison between acupuncture smoothing-liver and regulating-spleen method and regulating Governor Vessel method for menopausal insomnia].

    Science.gov (United States)

    Lu, Chen; Yang, Xiu-Juan; Hu, Jie

    2014-08-01

    To compare the efficacy difference among acupuncture smoothing-liver and regulating-spleen method, regulating Governor Vessel method and oral administration of western medicine for menopausal insomnia. One hundred and fifty-six cases of menopausal insomnia were randomized into a smoothing-liver and regulating-spleen group (group A), a regulating Governor Vessel group (group B) and a medication group (group C), 52 cases in each one. Acupuncture at Zhongwan (CV 12), Daheng (SP 15), Sanyinjiao (SP 6) and Taichong (LR 3), etc. was applied in the group A; acupuncture at Baihui (GV 20), Fengfu (GV 16), Shenting (GV 24) and Yintang (GV 29), etc. was used in the group B; oral administration of estazolam tablets (1 mg each-day) was adapted in the group C, all once a day for totally 30 days. The each item score and total score in Pittsburgh sleep quality index (PSQI) were evaluated before and after treatment in each group, also the efficacy in each group was assessed. After the treatment, the sleeping rate in the group A and B was significantly higher than that in the group C (both P vs 63.5% (33/52), both P vs 23.1% (12/52) and 25.0% (13/52), both P Acupuncture has better effect for menopausal insomnia than estazolam. Between the two acupuncture methods, the acupuncture method of smoothing-liver and regulating-spleen has a better effect.

  9. Pre-operative embolisation of internal carotid artery branches and pial vessels in hypervascular brain tumours.

    Science.gov (United States)

    Yoon, Y S; Ahn, J Y; Chang, J H; Cho, J H; Suh, S H; Lee, B H; Lee, K S

    2008-05-01

    Pre-operative embolisation is an effective method used to reduce intra-operative bleeding and operative difficulty in hypervascular brain tumour surgery. However, embolisation of the internal carotid artery (ICA) and pial tumour feeding branches has certain limitations. From March 2000 to November 2006, 8 patients underwent superselective embolisation for hypervascular brain tumour. Seven tumours were extra-axial (6 meningiomas, 1 solitary fibrous tumour) and 1 was intra-axial (metastatic hepatocellular carcinoma). In all patients, feeding vessels from ICA branches or pial arteries were successfully embolised using superselective microcatheterisation. A provocative test was applied in 4 patients who had tumours adjacent to the motor cortex. Angiographic devascularisation was slight to extensive. Mean devascularisation on post-embolisation MRI ranged from 40 to 80% (mean 63.8%). One patient (12.5%) suffered an embolisation-related complication (loss of choroidal brush), but was not clinically worse because of the pre-existing blindness. Superselective embolisation of ICA branches or pial vessels should be performed if several conditions are met, especially angiographic findings, pre-existing neurologic deficits, provocative test, and technical feasibility. If the ICA embolisation for hypervascular tumour is successfully achieved, the bleeding loss and operative risk can be reduced.

  10. Effect of impulse vibration and noise on vasomotor function of peripheral blood vessels among pneumatic forge hammer operators.

    Science.gov (United States)

    Solecki, L

    1995-01-01

    An evaluation of the effect of impulse vibration and noise on vasomotor function of blood vessels among pneumatic forge hammer operators has been presented based on thermal tests (cooling). The study covered the following groups of workers; pneumatic forge hammer operators (I), pneumatic forging hammer operators (II), hammer operator's assistants (III), operators of forging presses and machines (IV) and the control group. The results of the study showed that in groups I and III it was impulse noise not vibration that caused changes in the functioning of peripheral blood vessels.

  11. High Endothelial Venules and Other Blood Vessels: Critical Regulators of Lymphoid Organ Development and Function.

    Science.gov (United States)

    Ager, Ann

    2017-01-01

    The blood vasculature regulates both the development and function of secondary lymphoid organs by providing a portal for entry of hemopoietic cells. During the development of lymphoid organs in the embryo, blood vessels deliver lymphoid tissue inducer cells that initiate and sustain the development of lymphoid tissues. In adults, the blood vessels are structurally distinct from those in other organs due to the requirement for high levels of lymphocyte recruitment under non-inflammatory conditions. In lymph nodes (LNs) and Peyer's patches, high endothelial venules (HEVs) especially adapted for lymphocyte trafficking form a spatially organized network of blood vessels, which controls both the type of lymphocyte and the site of entry into lymphoid tissues. Uniquely, HEVs express vascular addressins that regulate lymphocyte entry into lymphoid organs and are, therefore, critical to the function of lymphoid organs. Recent studies have demonstrated important roles for CD11c+ dendritic cells in the induction, as well as the maintenance, of vascular addressin expression and, therefore, the function of HEVs. Tertiary lymphoid organs (TLOs) are HEV containing LN-like structures that develop inside organized tissues undergoing chronic immune-mediated inflammation. In autoimmune lesions, the development of TLOs is thought to exacerbate disease. In cancerous tissues, the development of HEVs and TLOs is associated with improved patient outcomes in several cancers. Therefore, it is important to understand what drives the development of HEVs and TLOs and how these structures contribute to pathology. In several human diseases and experimental animal models of chronic inflammation, there are some similarities between the development and function of HEVs within LN and TLOs. This review will summarize current knowledge of how hemopoietic cells with lymphoid tissue-inducing, HEV-inducing, and HEV-maintaining properties are recruited from the bloodstream to induce the development and

  12. Study on operation conditions and an operation system of a nuclear powered submersible research vessel, 'report of working group on application of a very small nuclear reactor to an ocean research'

    Energy Technology Data Exchange (ETDEWEB)

    Ura, Tamaki [Tokyo Univ., Tokyo (Japan); Takamasa, Tomoji [Tokyo Univ. of Mercantile Marine, Tokyo (Japan); Nishimura, Hajime [Japan Marine Science and Technology Center, Yokosuka, Kanagawa (JP)] [and others

    2001-07-01

    JAERI has studied on design of a nuclear powered submersible research vessel, which will navigate under sea mainly in the Arctic Ocean, as a part of the design activity of advanced marine reactors. This report describes operation conditions and an operating system of the vessel, which were discussed by the specialists of hull design, sound positioning, ship motions and oceanography, etc. The design conditions on ship motions for submersible vessels were surveyed considering regulations in our country, and ship motions were evaluated in the cases of underwater and surface navigations taking account of observation activities in the Arctic Ocean. The effect of ship motions on the compact nuclear reactor SCR was assessed. A submarine transponder system and an on-ice communication buoy system were examined as a positioning and communication system, supposing the activity under ice. The interval between transponders or communication buoys was recommended as 130 km. Procedures to secure safety of nuclear powered submersible research vessel were discussed according to accidents on the hull or the nuclear reactor. These results were reflected to the concept of the nuclear powered submersible research vessel, and subjects to be settled in the next step were clarified. (author)

  13. Evaluation of acoustic emission signals during monitoring of thick-wall vessels operating at elevated temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Anastasopoulos, A.; Tsimogiannis, A. [Envirocoustics S.A., El. Venizelou 7 and Delfon, Athens (Greece)

    2004-07-01

    Acoustic Emission testing of thick wall vessels, operating at elevated temperatures is discussed and pattern recognition methodologies for AE data evaluation are presented. Two different types of testing procedures are addressed: Cool Down monitoring and semi-continuous periodic monitoring. In both types of tests, temperature variation is the driving force of AE as opposed to traditional AE testing where controlled pressure variation is used as AE stimulus. Representative examples of reactors cool down testing as well as in-process vessel monitoring are given. AE activity as a function of temperature and pressure variation is discussed. In addition to the real-time limited criteria application, unsupervised pattern recognition is applied as a post-processing tool for multidimensional sorting, noise discrimination, characterizing defects and/or damage. On the other hand, Supervised Pattern Recognition is used for data classification in repetitive critical tests, leading to an objective quantitative comparison between repeated tests. Results show that damage sustained by the equipment can be described by the plotting the cumulative energy of AE, from critical signal classes, versus temperature. Overall, the proposed methodology can reduce the complexity of AE tests in many cases leading to higher efficiency. The possibility for real time signals classification, during permanent AE installations and continuous monitoring is discussed. (orig.)

  14. 78 FR 59902 - Regulated Navigation Area; Special Buzzards Bay Vessel Regulation, Buzzards Bay, MA

    Science.gov (United States)

    2013-09-30

    ...://www.regulations.gov , type the docket number in the ``SEARCH'' box and click ``SEARCH.'' Click on..., except Federal holidays. You may submit comments, identified by docket number, using any one of the... only one of these three methods. FOR FURTHER INFORMATION CONTACT: If you have questions on this rule...

  15. Enhancing supply vessel safety

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    A supply-vessel bridge installation consists of a navigating bridge and a control position aft, from which operators control the ship when close to rigs or platforms, and operate winches and other loading equipment. The international Convention for Safety of I Ale at Sea (SOLAS) does not regulate the layout, so design varies to a large degree, often causing an imperfect working environment. As for other types of ships, more than half the offshore service vessel accidents at sea are caused by bridge system failures. A majority can be traced back to technical design, and operational errors. The research and development project NAUT-OSV is a response to the offshore industry's safety concerns. Analysis of 24 incidents involving contact or collision between supply vessels and offshore installations owned or operated by Norwegian companies indicated that failures in the bridge system were often the cause.

  16. Towards the Development of a Risk Model for Unmanned Vessels Design and Operations

    Directory of Open Access Journals (Sweden)

    Krzysztof Wrobel

    2016-07-01

    Full Text Available An unmanned merchant vessel seems to be escaping from the stage of idea exploration. Once the concept proofs its safety, it may become a part of maritime reality. Although the safety aspect of such a ship has been addressed by a handful of scholars, the problem remains open. This is mainly due to lack of knowledge regarding actual operational circumstances and design of unmanned ships, which are yet to be developed. In the attempt of bridging this gap, the risk analysis associated with unmanned ships needs to be carried out, where all relevant hazards and consequences are assessed and quantified in systematic manner. In this paper we present the results of a first step of such analysis, namely the hazard analysis associated with the unmanned ships. The list of hazards covers various aspects of unmanned shipping originating from both design and operational phases of vessel’s life. Subsequently the hazards and related consequences are organized in a casual manner, resulting in the development of a structure of a risk model.

  17. 75 FR 81176 - Drawbridge Operation Regulation; Rainey River, Rainer, MN

    Science.gov (United States)

    2010-12-27

    ... potentially increase access by, and to, small entities on the waterway. If you think that your business... significant economic impact on it, please submit a comment (see ADDRESSES) explaining why you think it... posted on the bridge so that it is plainly visible to vessel operators approaching the up or downstream...

  18. 76 FR 13312 - Drawbridge Operation Regulations; Fox River, Oshkosh, WI

    Science.gov (United States)

    2011-03-11

    ... positive. Both negative comments characterized the proposed 10-minute advance visual warning method to... communications with the remote operator. During the summer of 2010 the U.S. Coast Guard met with CN RR officials... provide vessels with a method of warning when the bridge is expected to either close for train traffic or...

  19. Applying Multi-Class Support Vector Machines for performance assessment of shipping operations: The case of tanker vessels

    DEFF Research Database (Denmark)

    Pagoropoulos, Aris; Møller, Anders H.; McAloone, Tim C.

    2017-01-01

    Energy efficient operations are a key competitive advantage for modern shipping companies. During the operation of the vessel, improvements in energy use can be achieved by not only by technical upgrades, but also through behavioural changes in the way the crew on board is operating the vessels...... of feature selection algorithms. Afterwards, a model based on Multi- Class Support Vector Machines (SVM) was constructed and the efficacy of the approach is shown through the application of a test set. The results demonstrate the importance and benefits of machine learning algorithms in driving energy...... efficiency on board, as well as the impact of power management on energy costs throughout the life cycle of the ships....

  20. Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels

    Science.gov (United States)

    Berkowitz, Dan E.; White, Ron; Li, Dechun; Minhas, Khalid M.; Cernetich, Amy; Kim, Soonyul; Burke, Sean; Shoukas, Artin A.; Nyhan, Daniel; Champion, Hunter C.; hide

    2003-01-01

    BACKGROUND: Although abnormal L-arginine NO signaling contributes to endothelial dysfunction in the aging cardiovascular system, the biochemical mechanisms remain controversial. L-arginine, the NO synthase (NOS) precursor, is also a substrate for arginase. We tested the hypotheses that arginase reciprocally regulates NOS by modulating L-arginine bioavailability and that arginase is upregulated in aging vasculature, contributing to depressed endothelial function. METHODS AND RESULTS: Inhibition of arginase with (S)-(2-boronoethyl)-L-cysteine, HCl (BEC) produced vasodilation in aortic rings from young (Y) adult rats (maximum effect, 46.4+/-9.4% at 10(-5) mol/L, P<0.01). Similar vasorelaxation was elicited with the additional arginase inhibitors N-hydroxy-nor-L-arginine (nor-NOHA) and difluoromethylornithine (DFMO). This effect required intact endothelium and was prevented by 1H-oxadiazole quinoxalin-1-one (P<0.05 and P<0.001, respectively), a soluble guanylyl cyclase inhibitor. DFMO-elicited vasodilation was greater in old (O) compared with Y rat aortic rings (60+/-6% versus 39+/-6%, P<0.05). In addition, BEC restored depressed L-arginine (10(-4) mol/L)-dependent vasorelaxant responses in O rings to those of Y. Arginase activity and expression were increased in O rings, whereas NOS activity and cyclic GMP levels were decreased. BEC and DFMO suppressed arginase activity and restored NOS activity and cyclic GMP levels in O vessels to those of Y. CONCLUSIONS: These findings demonstrate that arginase modulates NOS activity, likely by regulating intracellular L-arginine availability. Arginase upregulation contributes to endothelial dysfunction of aging and may therefore be a therapeutic target.

  1. 75 FR 75486 - Maritime Security Directive 104-6 (Rev. 4); Guidelines for U.S. Vessels Operating in High Risk...

    Science.gov (United States)

    2010-12-03

    ... Manager, Docket Operations, telephone 202-366-9826. SUPPLEMENTARY INFORMATION: Somali pirates operate... thwarting pirate attacks and incorporates lessons-learned since the issuance of Revision 2. MARSEC Directive... underway, the vessels are subjected to the same type of threats from attacking pirates. Vessels berthed in...

  2. 77 FR 10960 - Drawbridge Operation Regulation; Snake Creek, Islamorada, FL

    Science.gov (United States)

    2012-02-24

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Snake Creek, Islamorada, FL AGENCY... of Snake Creek Bridge, mile 0.5, across Snake Creek, in Islamorada, Florida. The regulation is set... Sheriff's Office has requested a temporary modification to the operating schedule of Snake Creek Bridge in...

  3. 76 FR 49664 - Drawbridge Operation Regulation; Beaufort Channel, Beaufort, NC

    Science.gov (United States)

    2011-08-11

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Beaufort Channel, Beaufort, NC AGENCY... the Grayden Paul Bridge across the Beaufort (Gallants) Channel, mile 0.1 at Beaufort, NC. The... current operating regulations of the Grayden Paul Bridge, across the Beaufort (Gallants) Channel, mile 0.1...

  4. 78 FR 43063 - Drawbridge Operation Regulations; Arthur Kill, NY

    Science.gov (United States)

    2013-07-19

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Arthur Kill, NY AGENCY: Coast Guard... District, has issued a temporary deviation from the regulations governing the operation of the Arthur Kill AK Railroad Bridge across Arthur Kill, mile 11.6, between Staten Island, New York and Elizabeth, New...

  5. Compliance with vessel speed restrictions to protect North Atlantic right whales

    National Research Council Canada - National Science Library

    Silber, Gregory K; Adams, Jeffrey D; Fonnesbeck, Christopher J

    2014-01-01

    .... We assessed vessel operator compliance with a December 2008 regulation aimed at reducing collisions with the endangered North Atlantic right whale that requires vessels 65 feet or greater in length...

  6. Status and Perspectives of Nuclear Reactor Pressure Vessel Life Extension up to 60 Years Operation in Belgium

    Energy Technology Data Exchange (ETDEWEB)

    Lucon, E.; Chaouadi, R.; Scibetta, M.; Van Walle, E.

    2009-09-15

    The scope of this report involves a safety evaluation of the reactor pressure vessel (RPV) against neutron embrittlement, in the most severely irradiation region (belt line) and in the event of a pressurized thermal shock. The irreplaceable RPV is considered to be the most critical component for lifetime considerations of the nuclear power plant. However, an application for operation extension will also depend upon a number of additional considerations, including the technical assessment of other plant components, as well as non-technical arguments (e.g. political, environmental, economical, strategical that are outside the scope this report. In the hypothesis of a request for operation extension, it is the responsibility of the utilities to provide the safety authorities with an exhaustive dossier demonstrating that safe extended operation is guaranteed. The role of the safety authorities is to critically evaluate the safety dossier for eventually granting the operation extension.

  7. Positive-feedback regulation of subchondral H-type vessel formation by chondrocyte promotes osteoarthritis development in mice.

    Science.gov (United States)

    Lu, Jiansen; Zhang, Haiyan; Cai, Daozhang; Zeng, Chun; Lai, Pinglin; Shao, Yan; Fang, Hang; Li, Delong; Ouyang, Jiayao; Zhao, Chang; Xie, Denghui; Huang, Bin; Yang, Jian; Jiang, Yu; Bai, Xiaochun

    2018-01-12

    Vascular-invasion-mediated interactions between activated articular chondrocytes and subchondral bone are essential for osteoarthritis (OA) development. Here, we determined the role of nutrient sensing mechanistic target of rapamycin complex 1 (mTORC1) signaling in the crosstalk across the bone cartilage interface and its regulatory mechanisms. Then mice with chondrocyte-specific mTORC1 activation (Tsc1 CKO and Tsc1 CKOER ) or inhibition (Raptor CKOER ) and their littermate controls were subjected to OA induced by destabilization of the medial meniscus (DMM) or not. DMM or Tsc1 CKO mice were treated with bevacizumab, a vascular endothelial growth factor (VEGF)-A antibody that blocks angiogenesis. Articular cartilage degeneration was evaluated using the Osteoarthritis Research Society International score. Immunostaining and western blotting were conducted to detect H-type vessels and protein levels in mice. Primary chondrocytes from mutant mice and ADTC5 cells were treated with interleukin-1β to investigate the role of chondrocyte mTORC1 in VEGF-A secretion and in vitro vascular formation. Clearly, H-type vessels were increased in subchondral bone in DMM-induced OA and aged mice. Cartilage mTORC1 activation stimulated VEGF-A production in articular chondrocyte and H-type vessel formation in subchondral bone. Chondrocyte mTORC1 promoted OA partially through formation of VEGF-A-stimulated subchondral H-type vessels. In particular, vascular-derived nutrients activated chondrocyte mTORC1, and stimulated chondrocyte activation and production of VEGF, resulting in further angiogenesis in subchondral bone. Thus a positive-feedback regulation of H-type vessel formation in subchondral bone by articular chondrocyte nutrient-sensing mTORC1 signaling is essential for the pathogenesis and progression of OA. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  8. 77 FR 66714 - Drawbridge Operation Regulation; Columbia River, Vancouver, WA

    Science.gov (United States)

    2012-11-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Columbia River, Vancouver, WA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from regulations. SUMMARY: The Coast Guard has...

  9. 77 FR 73967 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-12-12

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD... highway bridge at Wise Avenue across Bear Creek, mile 3.4, between Dundalk and Sparrows Point, MD. The... Regulation; Bear Creek, Dundalk, MD'' in the Federal Register (77 FR 5201). The rulemaking concerned would...

  10. Distributed situation awareness in complex collaborative systems: A field study of bridge operations on platform supply vessels.

    Science.gov (United States)

    Sandhåland, Hilde; Oltedal, Helle A; Hystad, Sigurd W; Eid, Jarle

    2015-06-01

    This study provides empirical data about shipboard practices in bridge operations on board a selection of platform supply vessels (PSVs). Using the theoretical concept of distributed situation awareness, the study examines how situation awareness (SA)-related information is distributed and coordinated at the bridge. This study thus favours a systems approach to studying SA, viewing it not as a phenomenon that solely happens in each individual's mind but rather as something that happens between individuals and the tools that they use in a collaborative system. Thus, this study adds to our understanding of SA as a distributed phenomenon. Data were collected in four field studies that lasted between 8 and 14 days on PSVs that operate on the Norwegian continental shelf and UK continental shelf. The study revealed pronounced variations in shipboard practices regarding how the bridge team attended to operational planning, communication procedures, and distracting/interrupting factors during operations. These findings shed new light on how SA might decrease in bridge teams during platform supply operations. The findings from this study emphasize the need to assess and establish shipboard practices that support the bridge teams' SA needs in day-to-day operations. Provides insights into how shipboard practices that are relevant to planning, communication and the occurrence of distracting/interrupting factors are realized in bridge operations.Notes possible areas for improvement to enhance distributed SA in bridge operations.

  11. 78 FR 56609 - Drawbridge Operation Regulations; Reynolds Channel, Lawrence, NY

    Science.gov (United States)

    2013-09-13

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Reynolds Channel, Lawrence, NY... 34893) governing the operation of the Atlantic Beach Bridge, mile 0.4, across Reynolds Channel, at... Channel, Lawrence, NY'', in the Federal Register (78 FR 34893). The temporary deviation concerned was for...

  12. 78 FR 56610 - Drawbridge Operation Regulations; Reynolds Channel, Lawrence, NY

    Science.gov (United States)

    2013-09-13

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Reynolds Channel, Lawrence, NY... operation of the Atlantic Beach Bridge, mile 0.4, across Reynolds Channel, at Lawrence, New York. This... Atlantic Beach Bridge, across Reynolds Channel, mile 0.4, at Lawrence, New York, has a vertical clearance...

  13. 77 FR 45247 - Drawbridge Operation Regulations; Gallants Channel, Beaufort, NC

    Science.gov (United States)

    2012-07-31

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Gallants Channel, Beaufort, NC... operation of the US 70 (Grayden Paul) Bridge, at mile 0.1, over Gallants Channel, at Beaufort, NC. The... out in 33 CFR 117.823, the draw of the US 70 (Grayden Paul) Bridge, at mile 0.1, over Gallants Channel...

  14. 78 FR 66265 - Drawbridge Operation Regulations; Reynolds Channel, Lawrence, NY

    Science.gov (United States)

    2013-11-05

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Reynolds Channel, Lawrence, NY... operation of the Atlantic Beach Bridge, mile 0.4, across Reynolds Channel, at Lawrence, New York. This... Atlantic Beach Bridge, across Reynolds Channel, mile 0.4, at Lawrence, New York, has a vertical clearance...

  15. 77 FR 37316 - Drawbridge Operation Regulations; Reynolds Channel, Nassau, NY

    Science.gov (United States)

    2012-06-21

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Reynolds Channel, Nassau, NY AGENCY... the Long Beach Bridge, mile 4.7, across Reynolds Channel, at Nassau, New York. This temporary... Operations, telephone 202-366-9826. SUPPLEMENTARY INFORMATION: The Long Beach Bridge, across Reynolds Channel...

  16. 78 FR 34893 - Drawbridge Operation Regulations; Reynolds Channel, Lawrence, NY

    Science.gov (United States)

    2013-06-11

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Reynolds Channel, Lawrence, NY... operation of the Atlantic Beach Bridge, mile 0.4, across Reynolds Channel, at Lawrence, New York. This...-9826. SUPPLEMENTARY INFORMATION: The Atlantic Beach Bridge, across Reynolds Channel, mile 0.4, at...

  17. ASSESSMENT OF THE POTENTIAL FOR HYDROGEN GENERATION DURING GROUTING OPERATIONS IN THE R- AND P-REACTOR VESSELS

    Energy Technology Data Exchange (ETDEWEB)

    Wiersma, B.

    2009-12-29

    The R- and P-reactor buildings were retired from service and are now being prepared for deactivation and decommissioning (D&D). D&D activities will consist primarily of immobilizing contaminated components and structures in a grout-like formulation. Aluminum corrodes very rapidly when it comes in contact with the alkaline grout materials and as a result produces hydrogen gas. To address this potential deflagration/explosion hazard, the Materials Science and Technology Directorate (MS&T) of the Savannah River National Laboratory (SRNL) has been requested to review and evaluate existing experimental and analytical studies of this issue to determine if any process constraints on the chemistry of the fill material and the fill operation are necessary. Various options exist for the type of grout material that may be used for D&D of the reactor vessels. The grout formulation options include ceramicrete (pH 6-8), low pH portland cement + silica fume grout (pH 10.4), or Portland cement grout (pH 12.5). The assessment concluded that either ceramicrete or the silica fume grout may be used to safely grout the P-reactor vessel. The risk of accumulation of a flammable mixture of hydrogen between the grout-air interface and the top of the reactor is very low. Portland cement grout, on the other hand, for the same range of process parameters does not provide a significant margin of safety against the accumulation of flammable gas in the reactor vessel during grouting operations in the P-reactor vessel. It is recommended that this grout not be utilized for this task. The R-reactor vessel contains significantly less aluminum and thus a Portland cement grout may be considered as well. For example, if the grout fill rate is less than 1 inch/min and the grout temperature is maintained at 70 C or less, the risk of hydrogen accumulation in the R-reactor vessel is very low for the Portland cement. Alternatively, if the grout fill rate is less than 0.5 inch/min and the grout is maintained

  18. Commercial Vessel Safety. Economic Benefits. Appendix A. Estimation Procedures for Benefits of Marine Safety Regulations.

    Science.gov (United States)

    1980-02-01

    MICROCOPY HI SOLLJI ON If ( HAPI Report No. C D2-81 Commercial Vessel §afety. Economic 5enef its. APPENDIX Ae ESTIMATIONrOCEDURES FOR- ENEFITS...Lost From Work 124 10. Hospitalization Expense 125 11. Civilian Sa, aries 126 12. Military Pay and Allowance 127 13. Annual Standard Personnel Support...foreign benefits are not appropriate for inclusion in the cost-benefit analysis, they are often of interest due to the fact that the Coast Guard works

  19. Safe operation of a batch reactor: Safe storage of organic peroxides in supply vessels

    NARCIS (Netherlands)

    Steensma, M.; Steensma, Metske; Westerterp, K.R.

    1991-01-01

    In this study, we investigated the limits of safe operation for a cooled reactor, operated batchwise. As an example of a single-phase reaction, we studied the decomposition of t-butyl peroxypivalate, a well-known organic peroxide, undergoing self-heating at relatively low temperatures. If

  20. 75 FR 50718 - Regulations Implementing the Longshore and Harbor Workers' Compensation Act: Recreational Vessels

    Science.gov (United States)

    2010-08-17

    ... an employment- related hearing loss. This regulation echoes the statutory and regulatory standards... environmental laws suggests broad familiarity with their parameters within the boating community. Moreover, each...

  1. ISO and EIGA standards for cryogenic vessels and accessories

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    The EIGA/WG 6’s scope is cryogenic vessels and accessories, including their design, material compatibility, operational requirements and periodical inspection. The specific responsibilities include monitoring international standardization (ISO, CEN) and regulations (UN, TPED, PED...

  2. ASSESSMENT OF THE POTENTIAL FOR HYDROGEN GENERATION DURING GROUTING OPERATIONS IN THE R AND P REACTOR VESSELS

    Energy Technology Data Exchange (ETDEWEB)

    Wiersma, B.

    2010-05-24

    The R- and P-reactor buildings were retired from service and are now being prepared for deactivation and decommissioning (D and D). D and D activities consist primarily of immobilizing contaminated components and structures in a grout-like formulation. Aluminum corrodes very rapidly when it comes in contact with the alkaline grout materials and as a result produces hydrogen gas. To address this potential deflagration/explosion hazard, the Materials Science and Technology Directorate (MS and T) of the Savannah River National Laboratory (SRNL) has been requested to review and evaluate existing experimental and analytical studies of this issue to determine if any process constraints on the chemistry of the fill material and the fill operation are necessary. Various options exist for the type of grout material that may be used for D and D of the reactor vessels. The grout formulation options include ceramicrete (pH 6-8), low pH portland cement + silica fume grout (pH 10.4), or Portland cement groupt (pH 12.5). The assessment concluded that either ceramicrete or the silica fume grout may be used to safely grout the P-reactor vessel. The risk of accumulation of a flammable mixture of hydrogen between the grout-air interface and the top of the reactor is very low. Portland cement grout, on the other hand, for the same range of process parameters does not provide a margin of safety against the accumulation of flammable gas in the reactor vessel during grouting operations in the P-reactor vessel. It is recommended that this grout not be utilized for this task. The R-reactor vessel cotnains significantly less aluminum based on current facility process knowledge, surface observations, and drawings. Therefore, a Portland cement grout may be considered for grouting operations as well as the other grout formulations. For example, if the grout fill rate is less than 1 inch/min and the grout temperature is maintained at 70 C or less, the risk of hydrogen accumulation during fill

  3. 76 FR 37039 - Drawbridge Operation Regulation; Passaic River, Harrison, NJ

    Science.gov (United States)

    2011-06-24

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Passaic River, Harrison... across the Passaic River, mile 5.0, at Harrison, New Jersey. The owner of the bridge has requested relief... Amtrak Dock Bridge, mile 5.0, across the Passaic River, at Harrison, New Jersey, has a vertical clearance...

  4. 76 FR 65375 - Drawbridge Operation Regulation; Passaic River, Harrison, NJ

    Science.gov (United States)

    2011-10-21

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Passaic River, Harrison....0, at Harrison, New Jersey. The owner of the bridge has requested relief from crewing the bridge at... Passaic River at Harrison, New Jersey, has a vertical clearance in the closed position of 24 feet at mean...

  5. 76 FR 33974 - Changes to the Schedule of Operations Regulations

    Science.gov (United States)

    2011-06-10

    ... afterwards. To minimize the risk of food contamination during inspection and to ensure that inspection... to Whom the Regulation Applies FSIS received comments from Federal veterinarians stating that the... must be prepared and on the line when operations start, in particular Public Health Veterinarians and...

  6. 77 FR 1405 - Drawbridge Operation Regulation; Gulf Intracoastal Waterway, LA

    Science.gov (United States)

    2012-01-10

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Gulf Intracoastal Waterway, LA AGENCY... the SR 384 (Grand Lake) pontoon bridge across the Gulf Intracoastal Waterway, mile 231.4 West of... Lake Pontoon Bridge across the Gulf Intracoastal Waterway, mile 231.5 west of Harvey Lock (WHL), at...

  7. 77 FR 32393 - Drawbridge Operation Regulation; Gulf Intracoastal Waterway, LA

    Science.gov (United States)

    2012-06-01

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Gulf Intracoastal Waterway, LA AGENCY... Waterway (GIWW), mile 2.8 at New Orleans, Jefferson Parish, Louisiana. The deviation is necessary to allow... Waterway, mile 2.8 at New Orleans, Jefferson Parish, Louisiana. The bridge has a vertical clearance of 45...

  8. 78 FR 14185 - Drawbridge Operation Regulation; Gulf Intracoastal Waterway, LA

    Science.gov (United States)

    2013-03-05

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Gulf Intracoastal Waterway, LA AGENCY... drawbridge across the Harvey Canal Route, Gulf Intracoastal Waterway (GIWW), mile 2.8 at New Orleans... Waterway, mile 2.8 at New Orleans, Jefferson Parish, Louisiana. The bridge has a vertical clearance of 45...

  9. 76 FR 70345 - Drawbridge Operation Regulation; Gulf Intracoastal Waterway, LA

    Science.gov (United States)

    2011-11-14

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Gulf Intracoastal Waterway, LA AGENCY... Waterway (GIWW), mile 2.8 at Harvey, Jefferson Parish, Louisiana. The deviation is necessary to allow for... Span Bridge across the Harvey Canal Route, Intracoastal Waterway, mile 2.8 at Harvey, Jefferson Parish...

  10. 77 FR 24146 - Drawbridge Operation Regulation; Columbia River, Vancouver, WA

    Science.gov (United States)

    2012-04-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Columbia River, Vancouver, WA AGENCY... (BNSF) Railway Bridge across the Columbia River, mile 105.6, at Vancouver, WA. This deviation is...

  11. 77 FR 38004 - Drawbridge Operation Regulation; Columbia River, Vancouver, WA

    Science.gov (United States)

    2012-06-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Columbia River, Vancouver, WA AGENCY... across the Columbia River, mile 106.5, between Portland, Oregon and Vancouver, Washington. This deviation...

  12. 77 FR 53141 - Drawbridge Operation Regulation; Columbia River, Vancouver, WA

    Science.gov (United States)

    2012-08-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Columbia River, Vancouver, WA AGENCY... across the Columbia River, mile 106.5, between Portland, OR and Vancouver, WA. This deviation is...

  13. 78 FR 23487 - Drawbridge Operation Regulation; Columbia River, Vancouver, WA

    Science.gov (United States)

    2013-04-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Columbia River, Vancouver, WA AGENCY... across the Columbia River, mile 106.5, between Portland, Oregon and Vancouver, Washington. This deviation...

  14. 78 FR 15293 - Drawbridge Operation Regulations; Columbia River, Vancouver, WA

    Science.gov (United States)

    2013-03-11

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Columbia River, Vancouver, WA AGENCY... (BNSF) Railway Bridge across the Columbia River, mile 105.6, at Vancouver, WA. This deviation is... swing span of the BNSF Railway Bridge across the Columbia River at Vancouver, WA will be disabled and...

  15. 77 FR 5201 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-02-02

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD... across Bear Creek, mile 3.4, between Dundalk and Sparrows Point, MD. The proposed change will alter the... Avenue across Bear Creek, mile 3.4 between Dundalk and Sparrows Point, MD. This change would require the...

  16. 76 FR 60732 - Drawbridge Operation Regulations; Navesink (Swimming) River, NJ

    Science.gov (United States)

    2011-09-30

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Navesink (Swimming) River, NJ AGENCY... the Oceanic Bridge at mile 4.5 across the Navesink (Swimming) River between Oceanic and Locust Point...-9826. SUPPLEMENTARY INFORMATION: The Oceanic Bridge, across the Navesink (Swimming) River, mile 4.5...

  17. 78 FR 77591 - Drawbridge Operation Regulation; Shark River, NJ

    Science.gov (United States)

    2013-12-24

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Shark River, NJ AGENCY: Coast Guard... Shark River (South Channel), mile 0.8, at Belmar, NJ. The deviation is necessary to facilitate the... facilitate the replacement of motor seals and instrumentation on the bridge. The Route 71 Bridge across Shark...

  18. 77 FR 57022 - Drawbridge Operation Regulation; Shark River, Avon, NJ

    Science.gov (United States)

    2012-09-17

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Shark River, Avon, NJ AGENCY: Coast..., and the S35 bridge, mile 0.9, all of which are across the Shark River (South Channel), at Avon Township, NJ. This deviation is necessary to facilitate stringer replacement on the Shark River railroad...

  19. 78 FR 3836 - Drawbridge Operation Regulation; Shark River, Avon, NJ

    Science.gov (United States)

    2013-01-17

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Shark River, Avon, NJ AGENCY: Coast... which are across the Shark River (South Channel), at Avon Township, NJ. This deviation is necessary to facilitate machinery replacement on the Shark River railroad bridge. This temporary deviation will allow the...

  20. 78 FR 37456 - Drawbridge Operation Regulations; Reynolds Channel, Nassau, NY

    Science.gov (United States)

    2013-06-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Reynolds Channel, Nassau, NY AGENCY... the Long Beach Bridge, mile 4.7, across Reynolds Channel at Nassau, New York. Under this temporary...

  1. 78 FR 26508 - Drawbridge Operation Regulations; Reynolds Channel, Nassau, NY

    Science.gov (United States)

    2013-05-07

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Reynolds Channel, Nassau, NY AGENCY... the Long Beach Bridge, mile 4.7, across Reynolds Channel at Nassau, New York. Under this temporary...

  2. 49 CFR 176.78 - Use of power-operated industrial trucks on board vessels.

    Science.gov (United States)

    2010-10-01

    ..., whistle, gong, or other device that may be heard clearly above normal shipboard noises. (2) When the truck... so that moving of the controls will not result in injury to the operator when passing stanchions... additional interlock must be provided between the fan and the charging circuit so that the fan must be in...

  3. Federal Environmental Regulations Impacting Hydrocarbon Exploration, Drilling, and Production Operations

    Energy Technology Data Exchange (ETDEWEB)

    Carroll, Herbert B.; Johnson, William I.

    1999-04-27

    Waste handling and disposal from hydrocarbon exploration, drilling, and production are regulated by the US Environmental Protection Agency (EPA) through federal and state regulations and/or through implementation of federal regulations. Some wastes generated in these operations are exempt under the Resource Conservation and Recovery Act (RCRA) but are not exempt under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), Superfund Amendments and Reauthorization Act (SARA), and other federal environmental laws. Exempt wastes remain exempt only if they are not mixed with hazardous wastes or hazardous substances. Once mixture occurs, the waste must be disposed as a hazardous material in an approved hazardous waste disposal facility. Before the Clean Air Act as amended in 1990, air emissions from production, storage, steam generation, and compression facilities associated with hydrocarbon exploration, drilling, and production industry were not regulated. A critical proposed regulatory change which will significantly effect Class II injection wells for disposal of produced brine and injection for enhanced oil recovery is imminent. Federal regulations affecting hydrocarbon exploration, drilling and production, proposed EPA regulatory changes, and a recent significant US Court of Appeals decision are covered in this report. It appears that this industry will, in the future, fall under more stringent environmental regulations leading to increased costs for operators.

  4. ASSESSMENT OF THE POTENTIAL FOR HYDROGEN GENERATION DURING GROUTING OPERATIONS IN THE R AND P REACTOR VESSELS

    Energy Technology Data Exchange (ETDEWEB)

    Wiersma, B.

    2009-10-29

    The R- and P-reactor buildings were retired from service and are now being prepared for deactivation and decommissioning (D&D). D&D activities will consist primarily of immobilizing contaminated components and structures in a grout-like formulation. Aluminum corrodes very rapidly when it comes in contact with the alkaline grout materials and as a result produces hydrogen gas. To address this potential deflagration/explosion hazard, the Materials Science and Technology Directorate (MS&T) of the Savannah River National Laboratory (SRNL) has been requested to review and evaluate existing experimental and analytical studies of this issue to determine if any process constraints on the chemistry of the fill material and the fill operation are necessary. Various options exist for the type of grout material that may be used for D&D of the reactor vessels. The grout formulation options include ceramicrete (pH 6-8), low pH portland cement + silica fume grout (pH 10.4), or portland cement grout (pH 12.5). The assessment concluded that either ceramicrete or the silica fume grout may be used to safely grout the R- and P- reactor vessels. The risk of accumulation of a flammable mixture of hydrogen between the grout-air interface and the top of the reactor is very low. Conservative calculations estimate that either ceramicrete or the silica fume grout may be used to safely grout the R- and P- reactor vessels. The risk of accumulation of a flammable mixture of hydrogen between the grout-air interface and the top of the reactor is very low. Although these calculations are conservative, there are some measures that may be taken to further minimize the potential for hydrogen evolution. (1) Minimize the temperature of the grout as much as practical. Lower temperatures will mean lower hydrogen generation rates. Grout temperatures less than 100 C should however, still provide an adequate safety margin for the pH 8 and pH 10.4 grout formulations. (2) Minimize the fill rate as much as

  5. BIOASSAY VESSEL FAILURE ANALYSIS

    Energy Technology Data Exchange (ETDEWEB)

    Vormelker, P

    2008-09-22

    Two high-pressure bioassay vessels failed at the Savannah River Site during a microwave heating process for biosample testing. Improper installation of the thermal shield in the first failure caused the vessel to burst during microwave heating. The second vessel failure is attributed to overpressurization during a test run. Vessel failure appeared to initiate in the mold parting line, the thinnest cross-section of the octagonal vessel. No material flaws were found in the vessel that would impair its structural performance. Content weight should be minimized to reduce operating temperature and pressure. Outer vessel life is dependent on actual temperature exposure. Since thermal aging of the vessels can be detrimental to their performance, it was recommended that the vessels be used for a limited number of cycles to be determined by additional testing.

  6. TH2 cells and their cytokines regulate formation and function of lymphatic vessels.

    Science.gov (United States)

    Shin, Kihyuk; Kataru, Raghu P; Park, Hyeung Ju; Kwon, Bo-In; Kim, Tae Woo; Hong, Young Kwon; Lee, Seung-Hyo

    2015-02-04

    Lymphatic vessels (LVs) are critical for immune surveillance and involved in the pathogenesis of diverse diseases. LV density is increased during inflammation; however, little is known about how the resolution of LVs is controlled in different inflammatory conditions. Here we show the negative effects of T helper type 2 (TH2) cells and their cytokines on LV formation. IL-4 and IL-13 downregulate essential transcription factors of lymphatic endothelial cells (LECs) and inhibit tube formation. Co-culture of LECs with TH2 cells also inhibits tube formation, but this effect is fully reversed by interleukin (IL)-4 and/or IL-13 neutralization. Furthermore, the in vivo blockade of IL-4 and/or IL-13 in an asthma model not only increases the density but also enhances the function of lung LVs. These results demonstrate an anti-lymphangiogenic function of TH2 cells and their cytokines, suggesting a potential usefulness of IL-4 and/or IL-13 antagonist as therapeutic agents for allergic asthma through expanding LV mediated-enhanced antigen clearance from the inflammatory sites.

  7. Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation

    Directory of Open Access Journals (Sweden)

    Henry S. Cheng

    2014-12-01

    Full Text Available Cardiovascular diseases such as atherosclerosis are one of the leading causes of morbidity and mortality worldwide. The clinical manifestations of atherosclerosis, which include heart attack and stroke, occur several decades after initiation of the disease and become more severe with age. Inflammation of blood vessels plays a prominent role in atherogenesis. Activation of the endothelium by inflammatory mediators leads to the recruitment of circulating inflammatory cells, which drives atherosclerotic plaque formation and progression. Inflammatory signaling within the endothelium is driven predominantly by the pro-inflammatory transcription factor, NF-κB. Interestingly, activation of NF-κB is enhanced during the normal aging process and this may contribute to the development of cardiovascular disease. Importantly, studies utilizing mouse models of vascular inflammation and atherosclerosis are uncovering a network of noncoding RNAs, particularly microRNAs, which impinge on the NF-κB signaling pathway. Here we summarize the literature regarding the control of vascular inflammation by microRNAs, and provide insight into how these microRNA-based pathways might be harnessed for therapeutic treatment of disease. We also discuss emerging areas of endothelial cell biology, including the involvement of long noncoding RNAs and circulating microRNAs in the control of vascular inflammation.

  8. Neutron radiation embrittlement studies in support of continued operation, and validation by sampling of Magnox reactor steel pressure vessels and components

    Energy Technology Data Exchange (ETDEWEB)

    Jones, R.B.; Bolton, C.J. [Magnox Electric plc, Berkeley Centre, Glos (United Kingdom)

    1997-02-01

    Magnox steel reactor pressure vessels differ significantly from US LWR vessels in terms of the type of steel used, as well as their operating environment (dose level, exposure temperature range, and neutron spectra). The large diameter ferritic steel vessels are constructed from C-Mn steel plates and forgings joined together with manual metal and submerged-arc welds which are stress-relieved. All Magnox vessels are now at least thirty years old and their continued operation is being vigorously pursued. Vessel surveillance and other programmes are summarized which support this objective. The current understanding of the roles of matrix irradiation damage, irradiation-enhanced copper impurity precipitation and intergranular embrittlement effects is described in so far as these influence the form of the embrittlement and hardening trend curves for each material. An update is given on the influence of high temperature exposure, and on the role of differing neutron spectra. Finally, the validation offered by the results of an initial vessel sampling exercise is summarized together with the objectives of a more extensive future sampling programme.

  9. Behavioural Effects of Tourism on Oceanic Common Dolphins, Delphinus sp., in New Zealand: The Effects of Markov Analysis Variations and Current Tour Operator Compliance with Regulations

    Science.gov (United States)

    Meissner, Anna M.; Christiansen, Fredrik; Martinez, Emmanuelle; Pawley, Matthew D. M.; Orams, Mark B.; Stockin, Karen A.

    2015-01-01

    Common dolphins, Delphinus sp., are one of the marine mammal species tourism operations in New Zealand focus on. While effects of cetacean-watching activities have previously been examined in coastal regions in New Zealand, this study is the first to investigate effects of commercial tourism and recreational vessels on common dolphins in an open oceanic habitat. Observations from both an independent research vessel and aboard commercial tour vessels operating off the central and east coast Bay of Plenty, North Island, New Zealand were used to assess dolphin behaviour and record the level of compliance by permitted commercial tour operators and private recreational vessels with New Zealand regulations. Dolphin behaviour was assessed using two different approaches to Markov chain analysis in order to examine variation of responses of dolphins to vessels. Results showed that, regardless of the variance in Markov methods, dolphin foraging behaviour was significantly altered by boat interactions. Dolphins spent less time foraging during interactions and took significantly longer to return to foraging once disrupted by vessel presence. This research raises concerns about the potential disruption to feeding, a biologically critical behaviour. This may be particularly important in an open oceanic habitat, where prey resources are typically widely dispersed and unpredictable in abundance. Furthermore, because tourism in this region focuses on common dolphins transiting between adjacent coastal locations, the potential for cumulative effects could exacerbate the local effects demonstrated in this study. While the overall level of compliance by commercial operators was relatively high, non-compliance to the regulations was observed with time restriction, number or speed of vessels interacting with dolphins not being respected. Additionally, prohibited swimming with calves did occur. The effects shown in this study should be carefully considered within conservation management

  10. Behavioural effects of tourism on oceanic common dolphins, Delphinus sp., in New Zealand: the effects of Markov analysis variations and current tour operator compliance with regulations.

    Directory of Open Access Journals (Sweden)

    Anna M Meissner

    Full Text Available Common dolphins, Delphinus sp., are one of the marine mammal species tourism operations in New Zealand focus on. While effects of cetacean-watching activities have previously been examined in coastal regions in New Zealand, this study is the first to investigate effects of commercial tourism and recreational vessels on common dolphins in an open oceanic habitat. Observations from both an independent research vessel and aboard commercial tour vessels operating off the central and east coast Bay of Plenty, North Island, New Zealand were used to assess dolphin behaviour and record the level of compliance by permitted commercial tour operators and private recreational vessels with New Zealand regulations. Dolphin behaviour was assessed using two different approaches to Markov chain analysis in order to examine variation of responses of dolphins to vessels. Results showed that, regardless of the variance in Markov methods, dolphin foraging behaviour was significantly altered by boat interactions. Dolphins spent less time foraging during interactions and took significantly longer to return to foraging once disrupted by vessel presence. This research raises concerns about the potential disruption to feeding, a biologically critical behaviour. This may be particularly important in an open oceanic habitat, where prey resources are typically widely dispersed and unpredictable in abundance. Furthermore, because tourism in this region focuses on common dolphins transiting between adjacent coastal locations, the potential for cumulative effects could exacerbate the local effects demonstrated in this study. While the overall level of compliance by commercial operators was relatively high, non-compliance to the regulations was observed with time restriction, number or speed of vessels interacting with dolphins not being respected. Additionally, prohibited swimming with calves did occur. The effects shown in this study should be carefully considered within

  11. Behavioural effects of tourism on oceanic common dolphins, Delphinus sp., in New Zealand: the effects of Markov analysis variations and current tour operator compliance with regulations.

    Science.gov (United States)

    Meissner, Anna M; Christiansen, Fredrik; Martinez, Emmanuelle; Pawley, Matthew D M; Orams, Mark B; Stockin, Karen A

    2015-01-01

    Common dolphins, Delphinus sp., are one of the marine mammal species tourism operations in New Zealand focus on. While effects of cetacean-watching activities have previously been examined in coastal regions in New Zealand, this study is the first to investigate effects of commercial tourism and recreational vessels on common dolphins in an open oceanic habitat. Observations from both an independent research vessel and aboard commercial tour vessels operating off the central and east coast Bay of Plenty, North Island, New Zealand were used to assess dolphin behaviour and record the level of compliance by permitted commercial tour operators and private recreational vessels with New Zealand regulations. Dolphin behaviour was assessed using two different approaches to Markov chain analysis in order to examine variation of responses of dolphins to vessels. Results showed that, regardless of the variance in Markov methods, dolphin foraging behaviour was significantly altered by boat interactions. Dolphins spent less time foraging during interactions and took significantly longer to return to foraging once disrupted by vessel presence. This research raises concerns about the potential disruption to feeding, a biologically critical behaviour. This may be particularly important in an open oceanic habitat, where prey resources are typically widely dispersed and unpredictable in abundance. Furthermore, because tourism in this region focuses on common dolphins transiting between adjacent coastal locations, the potential for cumulative effects could exacerbate the local effects demonstrated in this study. While the overall level of compliance by commercial operators was relatively high, non-compliance to the regulations was observed with time restriction, number or speed of vessels interacting with dolphins not being respected. Additionally, prohibited swimming with calves did occur. The effects shown in this study should be carefully considered within conservation management

  12. Transient Ingrowth of Lymphatic Vessels into the Physiologically Avascular Cornea Regulates Corneal Edema and Transparency.

    Science.gov (United States)

    Hos, Deniz; Bukowiecki, Anne; Horstmann, Jens; Bock, Felix; Bucher, Franziska; Heindl, Ludwig M; Siebelmann, Sebastian; Steven, Philipp; Dana, Reza; Eming, Sabine A; Cursiefen, Claus

    2017-08-03

    Lymphangiogenesis is essential for fluid homeostasis in vascularized tissues. In the normally avascular cornea, however, pathological lymphangiogenesis mediates diseases like corneal transplant rejection, dry eye disease, and allergy. So far, a physiological role for lymphangiogenesis in a primarily avascular site such as the cornea has not been described. Using a mouse model of perforating corneal injury that causes acute and severe fluid accumulation in the cornea, we show that lymphatics transiently and selectively invade the cornea and regulate the resolution of corneal edema. Pharmacological blockade of lymphangiogenesis via VEGFR-3 inhibition results in increased corneal thickness due to delayed drainage of corneal edema and a trend towards prolonged corneal opacification. Notably, lymphatics are also detectable in the cornea of a patient with acute edema due to spontaneous Descemet´s (basement) membrane rupture in keratoconus, mimicking this animal model and highlighting the clinical relevance of lymphangiogenesis in corneal fluid homeostasis. Together, our findings provide evidence that lymphangiogenesis plays an unexpectedly beneficial role in the regulation of corneal edema and transparency. This might open new treatment options in blinding diseases associated with corneal edema and transparency loss. Furthermore, we demonstrate for the first time that physiological lymphangiogenesis also occurs in primarily avascular sites.

  13. 78 FR 47242 - Drawbridge Operation Regulation; Umpqua River, Reedsport, OR

    Science.gov (United States)

    2013-08-05

    ... entail painting, rust removal, and steel repairs which require full containment to keep paint and debris... number ] of vessels up to 75' in length to dock during non-opening hours down river from the U.S. 101.... and 6 p.m. Down river dock access will be made available during closure hours for vessels awaiting...

  14. 76 FR 2402 - Maritime Security Directive 104-6 (Rev 5); Guidelines for U.S. Vessels Operating in High Risk Waters

    Science.gov (United States)

    2011-01-13

    ... pirates operate along a 2,300 mile coast and in 2.5 million square miles of ocean. Given the size and... management practices that have proven to be successful in thwarting pirate attacks and incorporates lessons... subjected to the same type of threats from attacking pirates. Vessels berthed in high risk waters should...

  15. 49 CFR 39.9 - What may the owner or operator of a foreign-flag vessel do if it believes a provision of a...

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What may the owner or operator of a foreign-flag vessel do if it believes a provision of a foreign nation's law prohibits compliance with a provision of this part? 39.9 Section 39.9 Transportation Office of the Secretary of Transportation TRANSPORTATION FOR INDIVIDUALS WITH DISABILITIES: PASSENGER...

  16. The movement of lymph in the system of lymph node-lymph vessel and its regulation

    Directory of Open Access Journals (Sweden)

    Myrzakhanov Nurken

    2016-10-01

    Full Text Available Background This article presents the results of studying the specific features (rat, pig, sheep, cow of spontaneous rhythmic contractile activity of the lymph nodes of internal organs and body, the role of intranode pressure in the genesis of a node reduction of the lymph nodes activity regulation under the influence of biologically active substances, and the drug immunal and feed additives – polfamix on spontaneous contractile activity of a lymphatic node. Aims So far, well researched are the thin structural-topographic formation and innervation of the lymph circulation machine, the main functions (drainage, immunological, protein transport, etc. of the lymphatic system are set, which ensure the preservation of endoecological homeostasis of the organism environments. Methods We used the technique of recording contractions of isolated solitary lymph nodes of the body and internal organs, placed in an oxygenized chamber with Krebs medium. Results We found a direct link between the spontaneous rhythmic contractile activity of a lymph node and its internal pressure. A direct relationship is established: the higher within certain limits micronodular pressure is, the more intense is the reduction node (r+0,879. Conclusion As well as giving data from the manuscript there will be presentation of the main points of lymph node’s values in the organism.

  17. 46 CFR 289.2 - Vessels included.

    Science.gov (United States)

    2010-10-01

    ... CONSTRUCTION-DIFFERENTIAL SUBSIDY VESSELS, OPERATING-DIFFERENTIAL SUBSIDY VESSELS AND OF VESSELS SOLD OR ADJUSTED UNDER THE MERCHANT SHIP SALES ACT 1946 § 289.2 Vessels included. Vessels subject to the provisions of this part are: (a) All vessels which may in the future be constructed or sold with construction...

  18. The effects of marine vessel fuel sulfur regulations on ambient PM2.5 along the west coast of the U.S.

    Science.gov (United States)

    Kotchenruther, Robert A.

    2015-02-01

    This work uses PM2.5 data and Positive Matrix Factorization (PMF) modeling to explore the effects of two marine vessel fuel sulfur regulations along the west coast of the United States (US); California's (CA) Ocean-Going Vessel Clean Fuel Regulation (CA-CFR) implemented in July 2009 and the North American Emissions Control Area (NA-ECA) implemented in August 2012. Data from 31 chemically speciated PM2.5 monitors along the US west coast were analyzed and 9 sites with strong linear correlations between vanadium and nickel were selected for PMF modeling. The 9 sites were modeled independently and for 8 sites, 3 in CA and 5 in Washington State (WA), a well-defined factor linked to marine vessel residual fuel oil (RFO) combustion was identified. For these 8 sites, model results were subdivided into three time periods; a three year period prior to implementation of the CA-CFR, a three year period after the CA-CFR but prior to the NA-ECA, and a one year period after implementation of the NA-ECA. Marine vessel PM2.5 distributions were compared between the three time periods to determine if statistically significant reductions had occurred. Comparing marine vessel PM2.5 for the three years before and after CA-CFR implementation, all CA sites indicated statistically significant reductions, with reductions in annualized average marine vessel PM2.5 from 30 to 52% (0.09-0.78 μg/m3). Comparing marine vessel PM2.5 for the three years before NA-ECA implementation and the 1 year after, 2 of 5 WA sites indicated statistically significant reductions in annualized average impacts (45-50%, 0.12-0.23 μg/m3) and 1 of 3 sites in CA (46%, 0.04 μg/m3). These results demonstrate that marine vessel fuel sulfur regulations on the west coast of the US have been effective at reducing PM2.5 impacts from marine vessel RFO combustion at some locations, with the implementation of the CA-CFR showing more success than the NA-ECA. The greater observed success of the CA-CFR is, to some extent

  19. PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7

    Science.gov (United States)

    Martin, Maud; Geudens, Ilse; Bruyr, Jonathan; Potente, Michael; Bleuart, Anouk; Lebrun, Marielle; Simonis, Nicolas; Deroanne, Christophe; Twizere, Jean-Claude; Soubeyran, Philippe; Peixoto, Paul; Mottet, Denis; Janssens, Veerle; Hofmann, Wolf-Karsten; Claes, Filip; Carmeliet, Peter; Kettmann, Richard; Gerhardt, Holger; Dequiedt, Franck

    2013-01-01

    To supply tissues with nutrients and oxygen, the cardiovascular system forms a seamless, hierarchically branched, network of lumenized tubes. Here, we show that maintenance of patent vessel lumens requires the Bα regulatory subunit of protein phosphatase 2A (PP2A). Deficiency of Bα in zebrafish precludes vascular lumen stabilization resulting in perfusion defects. Similarly, inactivation of PP2A-Bα in cultured ECs induces tubulogenesis failure due to alteration of cytoskeleton dynamics, actomyosin contractility and maturation of cell–extracellular matrix (ECM) contacts. Mechanistically, we show that PP2A-Bα controls the activity of HDAC7, an essential transcriptional regulator of vascular stability. In the absence of PP2A-Bα, transcriptional repression by HDAC7 is abrogated leading to enhanced expression of the cytoskeleton adaptor protein ArgBP2. ArgBP2 hyperactivates RhoA causing inadequate rearrangements of the EC actomyosin cytoskeleton. This study unravels the first specific role for a PP2A holoenzyme in development: the PP2A-Bα/HDAC7/ArgBP2 axis maintains vascular lumens by balancing endothelial cytoskeletal dynamics and cell–matrix adhesion. PMID:23955003

  20. 33 CFR 165.1405 - Regulated Navigation Areas and Security Zones; Designated Escorted Vessels-Philippine Sea and...

    Science.gov (United States)

    2010-07-01

    ... Security Zones; Designated Escorted Vessels-Philippine Sea and Apra Harbor, Guam (including Cabras Island... Areas and Security Zones; Designated Escorted Vessels-Philippine Sea and Apra Harbor, Guam (including... point of origin. (2) Apra Harbor, Guam—All waters from surface to bottom of Apra Harbor, Guam, shoreward...

  1. Distinct roles of L- and T-type voltage-dependent Ca2+ channels in regulation of lymphatic vessel contractile activity.

    Science.gov (United States)

    Lee, Stewart; Roizes, Simon; von der Weid, Pierre-Yves

    2014-12-15

    Lymph drainage maintains tissue fluid homeostasis and facilitates immune response. It is promoted by phasic contractions of collecting lymphatic vessels through which lymph is propelled back into the blood circulation. This rhythmic contractile activity (i.e. lymphatic pumping) increases in rate with increase in luminal pressure and relies on activation of nifedipine-sensitive voltage-dependent Ca(2+) channels (VDCCs). Despite their importance, these channels have not been characterized in lymphatic vessels. We used pressure- and wire-myography as well as intracellular microelectrode electrophysiology to characterize the pharmacological and electrophysiological properties of L-type and T-type VDCCs in rat mesenteric lymphatic vessels and evaluated their particular role in the regulation of lymphatic pumping by stretch. We complemented our study with PCR and confocal immunofluorescence imaging to investigate the expression and localization of these channels in lymphatic vessels. Our data suggest a delineating role of VDCCs in stretch-induced lymphatic vessel contractions, as the stretch-induced increase in force of lymphatic vessel contractions was significantly attenuated in the presence of L-type VDCC blockers nifedipine and diltiazem, while the stretch-induced increase in contraction frequency was significantly decreased by the T-type VDCC blockers mibefradil and nickel. The latter effect was correlated with a hyperpolarization. We propose that activation of T-type VDCCs depolarizes membrane potential, regulating the frequency of lymphatic contractions via opening of L-type VDCCs, which drive the strength of contractions. © 2014 The Authors. The Journal of Physiology © 2014 The Physiological Society.

  2. 46 CFR 111.12-7 - Voltage regulation and parallel operation.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Voltage regulation and parallel operation. 111.12-7... ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Generator Construction and Circuits § 111.12-7 Voltage regulation and parallel operation. Voltage regulation and parallel operation must meet: (a) For AC systems: sections 4-2-3...

  3. Marine pollution originating from purse seine and longline fishing vessel operations in the Western and Central Pacific Ocean, 2003-2015.

    Science.gov (United States)

    Richardson, Kelsey; Haynes, David; Talouli, Anthony; Donoghue, Michael

    2017-03-01

    Fisheries observer data recorded between 2003 and 2015 on-board purse seine and longline vessels operating in the Western and Central Pacific Ocean reported more than 10 000 pollution incidents within the exclusive economic zones (EEZs) of 25 Pacific countries and territories, and in international waters. A majority of the reported purse seine pollution incidents related to dumping of plastics waste. Other common pollution incidents related to oil spillages and to abandoned, lost or dumped fishing gear. Data analysis highlighted the need for increased monitoring, reporting, and enforcement of pollution violations by all types of fishing vessels operating in the Pacific region; a regional outreach and compliance assistance programme on marine pollution prevention and improvements in Pacific port waste reception facilities.

  4. Implementing arithmetic and other analytic operations by transcriptional regulation.

    Directory of Open Access Journals (Sweden)

    Sean M Cory

    2008-04-01

    Full Text Available The transcriptional regulatory machinery of a gene can be viewed as a computational device, with transcription factor concentrations as inputs and expression level as the output. This view begs the question: what kinds of computations are possible? We show that different parameterizations of a simple chemical kinetic model of transcriptional regulation are able to approximate all four standard arithmetic operations: addition, subtraction, multiplication, and division, as well as various equality and inequality operations. This contrasts with other studies that emphasize logical or digital notions of computation in biological networks. We analyze the accuracy and precision of these approximations, showing that they depend on different sets of parameters, and are thus independently tunable. We demonstrate that networks of these "arithmetic" genes can be combined to accomplish yet more complicated computations by designing and simulating a network that detects statistically significant elevations in a time-varying signal. We also consider the much more general problem of approximating analytic functions, showing that this can be achieved by allowing multiple transcription factor binding sites on the promoter. These observations are important for the interpretation of naturally occurring networks and imply new possibilities for the design of synthetic networks.

  5. Computational hydrodynamic comparison of a mini vessel and a USP 2 dissolution testing system to predict the dynamic operating conditions for similarity of dissolution performance.

    Science.gov (United States)

    Wang, Bing; Bredael, Gerard; Armenante, Piero M

    2018-01-16

    The hydrodynamic characteristics of a mini vessel and a USP 2 dissolution testing system were obtained and compared to predict the tablet-liquid mass transfer coefficient from velocity distributions near the tablet and establish the dynamic operating conditions under which dissolution in mini vessels could be conducted to generate concentration profiles similar to those in the USP 2. Velocity profiles were obtained experimentally using Particle Image Velocimetry (PIV). Computational Fluid Dynamics (CFD) was used to predict the velocity distribution and strain rate around a model tablet. A CFD-based mass transfer model was also developed. When plotted against strain rate, the predicted tablet-liquid mass transfer coefficient was found to be independent of the system where it was obtained, implying that a tablet would dissolve at the same rate in both systems provided that the concentration gradient between the tablet surface and the bulk is the same, the tablet surface area per unit liquid volume is identical, and the two systems are operated at the appropriate agitation speeds specified in this work. The results of this work will help dissolution scientists operate mini vessels so as to predict the dissolution profiles in the USP 2, especially during the early stages of drug development. Copyright © 2018 Elsevier B.V. All rights reserved.

  6. 77 FR 16928 - Drawbridge Operation Regulation; Miami River, Miami, FL

    Science.gov (United States)

    2012-03-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND... congestion during Miami Marlins home baseball games poses a safety concern. This 90 day test deviation will... of Miami Marlins home baseball games. Tugs and tugs with tows, public vessels of the United States...

  7. 33 CFR 155.1025 - Operating restrictions and interim operating authorization.

    Science.gov (United States)

    2010-07-01

    ... REGULATIONS FOR VESSELS Tank Vessel Response Plans for Oil § 155.1025 Operating restrictions and interim... vessel may continue to handle, store, transport, transfer, or lighter oil for 2 years after the date of... handle, store, transport, transfer, or lighter oil if— (1) The Coast Guard determines that the response...

  8. 75 FR 30750 - Drawbridge Operation Regulation; Arkansas Waterway, Little Rock, AR

    Science.gov (United States)

    2010-06-02

    ..., Little Rock, AR AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast Guard... Waterway at mile 119.6 at Little Rock, AR, so that vessel operators will contact the remote drawbridge... the Baring Cross Railroad Drawbridge, mile 119.6, at Little Rock, AR is maintained in the closed...

  9. Containment vessel drain system

    Energy Technology Data Exchange (ETDEWEB)

    Harris, Scott G.

    2018-01-30

    A system for draining a containment vessel may include a drain inlet located in a lower portion of the containment vessel. The containment vessel may be at least partially filled with a liquid, and the drain inlet may be located below a surface of the liquid. The system may further comprise an inlet located in an upper portion of the containment vessel. The inlet may be configured to insert pressurized gas into the containment vessel to form a pressurized region above the surface of the liquid, and the pressurized region may operate to apply a surface pressure that forces the liquid into the drain inlet. Additionally, a fluid separation device may be operatively connected to the drain inlet. The fluid separation device may be configured to separate the liquid from the pressurized gas that enters the drain inlet after the surface of the liquid falls below the drain inlet.

  10. Modeling Relevant to Safe Operations of U.S. Navy Vessels in Arctic Conditions: Physical Modeling of Ice Loads

    Science.gov (United States)

    2016-06-01

    www.erdc.usace.army.mil. To search for other technical reports published by ERDC, visit the ERDC online library at http://acwc.sdp.sirsi.net/ client /default...Science and Technology SNAME Society of Naval Architects and Marine Engineers SSC Ship Structure Committee USCG U.S. Coast Guard WMO World...ice-capable vessels, naval architects have traditionally used physical modeling to measure the vessels’ re- sistance, propulsion, and maneuvering

  11. Operating principles of tristable circuits regulating cellular differentiation

    Science.gov (United States)

    Jia, Dongya; Jolly, Mohit Kumar; Harrison, William; Boareto, Marcelo; Ben-Jacob, Eshel; Levine, Herbert

    2017-06-01

    Many cell-fate decisions during embryonic development are governed by a motif comprised of two transcription factors (TFs) A and B that mutually inhibit each other and may self-activate. This motif, called as a self-activating toggle switch (SATS), can typically have three stable states (phenotypes)—two corresponding to differentiated cell fates, each of which has a much higher level of one TF than the other—≤ft(A,~B\\right)=≤ft(1,~0\\right) or ≤ft(0,~1\\right) —and the third state corresponding to an ‘undecided’ stem-like state with similar levels of both A and B—≤ft(A,~B\\right)=≤ft(1/2,1/2\\right) . Furthermore, two or more SATSes can be coupled together in various topologies in different contexts, thereby affecting the coordination between multiple cellular decisions. However, two questions remain largely unanswered: (a) what governs the co-existence and relative stability of these three stable states? (b) What orchestrates the decision-making of coupled SATSes? Here, we first demonstrate that the co-existence and relative stability of the three stable states in an individual SATS can be governed by the relative strength of self-activation, external signals activating and/or inhibiting A and B, and mutual degradation between A and B. Simultaneously, we investigate the effects of these factors on the decision-making of two coupled SATSes. Our results offer novel understanding into the operating principles of individual and coupled tristable self-activating toggle switches (SATSes) regulating cellular differentiation and can yield insights into synthesizing three-way genetic circuits and understanding of cellular reprogramming.

  12. An investment appraisal method to compare LNG-fueled and conventional vessels

    NARCIS (Netherlands)

    Fokkema, Jan Eise; Buijs, Paul; Vis, Iris F. A.

    2017-01-01

    Ever stricter emission regulations stimulate vessel owners to consider the adoption of alternative marine fuels, such as Liquefied Natural Gas (LNG). In deciding whether to invest in LNG-fueled vessels, initial investment and operating costs are decisive factors that have not yet been fully studied

  13. 76 FR 34890 - Pacific Halibut Fisheries; Limited Access for Guided Sport Charter Vessels in Alaska

    Science.gov (United States)

    2011-06-15

    ...; Limited Access for Guided Sport Charter Vessels in Alaska AGENCY: National Marine Fisheries Service (NMFS...: This rule clarifies regulations that apply to vessels operating in the guided sport (charter) fishery...: This rule is effective on June 15, 2011. ADDRESSES: Electronic copies of this action and other related...

  14. A regulator`s perspective on NRC`s participation in the operations & maintenance committees

    Energy Technology Data Exchange (ETDEWEB)

    Wessman, R.H.

    1996-12-01

    As a regulator fairly new to the American Society of Mechanical Engineers (ASME) Operations and Maintenance (O&M) Committee process, the author does not have a personal historical perspective as do many of the longer-term, and highly respected, members of the O&M Committee. However, as Branch Chief of the Mechanical Engineering Branch, Division of Engineering, in the Office of Nuclear Reactor Regulation at the NRC for just over two years, he has responsibility for the regulatory agency`s review of licensee actions involving the products that come from the efforts of the O&M Committee, as well as responsibility for portions of the activities of interest to other ASME Code groups such as Section III, Section XI, and Qualification of Mechanical Equipment. As a result, the author has learned a great deal about the code process in a short time. Here he gives his perspectives on the process and provides a few thoughts on the direction for the future.

  15. 78 FR 71675 - Update of the Office of Nuclear Reactor Regulation's Electronic Operating Reactor Correspondence

    Science.gov (United States)

    2013-11-29

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Update of the Office of Nuclear Reactor Regulation's Electronic Operating Reactor Correspondence... Regulatory Commission. Michele G. Evans, Director, Division of Operating Reactor Licensing, Office of Nuclear...

  16. 77 FR 22520 - Drawbridge Operation Regulation; Lafourche Bayou, LA

    Science.gov (United States)

    2012-04-16

    ... will then become highlighted in blue. In the ``Document Type'' drop down menu select ``Proposed Rules... of materials, performance, design, or operation; test methods; sampling procedures; and related...

  17. 76 FR 40237 - Drawbridge Operation Regulation; Illinois Waterway, Near Morris, IL

    Science.gov (United States)

    2011-07-08

    ..., Eighth Coast Guard District, has issued a temporary deviation from the regulation governing the operation... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Illinois Waterway, Near Morris, IL... inspection or copying at the Docket Management Facility (M-30), U.S. Department of Transportation, West...

  18. 75 FR 1706 - Drawbridge Operation Regulations; Upper Mississippi River, Dubuque, IA

    Science.gov (United States)

    2010-01-13

    ..., Eighth Coast Guard District has issued a temporary deviation from the regulation governing the operations... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Upper Mississippi River, Dubuque, IA... ``Search''. They are also available for inspection or copying at the Docket Management Facility (M-30), U.S...

  19. 78 FR 53666 - Drawbridge Operation Regulation; Wolf River, Gills Landing and Winneconne, WI

    Science.gov (United States)

    2013-08-30

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Wolf River, Gills... revising the operating schedule that governs the Winneconne Highway Bridge at Mile 2.4, and the Canadian National Railroad Bridge at mile 27.8, both over the Wolf River. A review of the current regulation was...

  20. 75 FR 71017 - Drawbridge Operation Regulations; Bayou Liberty, St. Tammany Parish, Slidell, LA

    Science.gov (United States)

    2010-11-22

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Bayou Liberty, St. Tammany Parish... regulation governing the operation of the S433 bridge over Bayou Liberty, mile 2.0, St. Tammany Parish... Liberty at mile 2.0, in St. Tammany Parish. The vertical clearance is 7.59 feet (2.31m) above the 2...

  1. 75 FR 76322 - Drawbridge Operation Regulation; Fox River, Oshkosh, WI

    Science.gov (United States)

    2010-12-08

    ... will then become highlighted in blue. In the ``Document Type'' drop down menu select ``Proposed Rules... draw is in motion, the remote operator shall monitor waterway traffic by remote visual inspection to...

  2. 77 FR 6042 - Drawbridge Operation Regulation; Christina River, Wilmington, DE

    Science.gov (United States)

    2012-02-07

    ... blue. In the ``Document Type'' drop down menu select ``Proposed Rules'' and insert ``USCG-2011-1136... of materials, performance, design, or operation; test methods; sampling procedures; and related...

  3. 75 FR 28766 - Drawbridge Operation Regulations; Passaic River, Clifton, NJ

    Science.gov (United States)

    2010-05-24

    ... ``Document Type'' drop down menu select ``Proposed Rules'' and insert ``USCG-2010-0200'' in the ``Keyword... standards (e.g., specifications of materials, performance, design, or operation; test methods; sampling...

  4. 77 FR 12514 - Drawbridge Operation Regulation; Hood Canal, WA

    Science.gov (United States)

    2012-03-01

    ... blue. In the ``Document Type'' drop down menu select ``Proposed Rules'' and insert ``USCG-2012-0074... standards are technical standards (e.g., specifications of materials, performance, design, or operation...

  5. 77 FR 67319 - Drawbridge Operation Regulation; Lake Champlain, Swanton, VT

    Science.gov (United States)

    2012-11-09

    ... operation schedule was established many years ago when the bridge was crewed. In recent years the bridge was... effect on the supply, distribution, or use of energy. The Administrator of the Offices of Information and...

  6. Mycotoxins: Risks, regulations and European co-operation

    Directory of Open Access Journals (Sweden)

    Van Egmond Hans P.

    2013-01-01

    Full Text Available Mycotoxins and mycotoxicises have been problems of the past and the present, but scientific attention for mycotoxins did not start until the early 1960’s. Nowa­days, many mycotoxins are known, and their occurrence in food and animal feed may cause various adverse effects on human and animal health, including carcinogenic, hepatotoxic, immunotoxic, nephrotoxic, neurotoxic, oestrogenic and teratogenic effects. Some important mycotoxins include the aflatoxins, ochratoxin A, the fumonisins and the trichothecenes, and their significance is briefly described. To protect human and animal health, many countries have enacted specific regulations for mycotoxins in food and animal feed. Risk assessment is a major factor for scientific underpinning of regulations, but other factors such as availability of adequate sampling and analysis procedures also play an important a role in the establishment of mycotoxin regulations. In addition, socio-economic factors such as cost-benefit considerations, trade issues and sufficiency of food supply are equally important in the decision-taking process to come to meaningful regulations. Nowadays, more than 100 countries have formal mycotoxin regulations for food and feed. The mycotoxin regulations are the most stringent in the EU, where various organizations and pan-European networks contribute to combat the mycotoxin problem. It is to be expected that mycotoxins will stay with us in the future and climate change might have a negative influence in this respect. Several possibilities exist to mitigate the problems caused by mycotoxins. In particular prevention of mould growth and mycotoxin formation is key to the control of mycotoxins.

  7. 78 FR 70220 - Drawbridge Operation Regulation; Umpqua River, Reedsport, OR

    Science.gov (United States)

    2013-11-25

    ... notice and will limit the openings to twice daily; once in the morning and once in the evening. DATES... regulation in that the presently the bridge will open at all times (except during authorized closure periods... exercise good stewardship of public funding during ODOT extensive bridge maintenance and restoration...

  8. 76 FR 69632 - Drawbridge Operation Regulation; Calcasieu River, Westlake, LA

    Science.gov (United States)

    2011-11-09

    ... ] docket are part of docket USCG-2011-1020 and are available online by going to http://www.regulations.gov , inserting USCG-2011-1020 in the ``Keyword'' box and then clicking ``Search''. They are also available for... order to remove the existing structural steel, shafts, and gears; and to install two new main drive...

  9. 33 CFR 151.2040 - What are the mandatory ballast water management requirements for vessels equipped with ballast...

    Science.gov (United States)

    2010-07-01

    ... international laws or regulations. Ballast water carried in any tank containing a residue of oil, NLS, or any... vessel bound for the Great Lakes or Hudson River, which has operated beyond the EEZ (which includes the...

  10. 75 FR 28757 - Drawbridge Operation Regulation; Long Island, New York Inland Waterway From East Rockaway Inlet...

    Science.gov (United States)

    2010-05-24

    ...The Commander, First Coast Guard District, has issued a temporary deviation from the regulation governing the operation of the Wantagh State Parkway Bridge across Sloop Channel at mile 15.4, at Jones Beach, New York. Under this temporary deviation the bridge may operate on a special operating schedule for five months to facilitate the completion of new bridge construction.

  11. 76 FR 13288 - Drawbridge Operation Regulations; Hackensack River, Secaucus, NJ

    Science.gov (United States)

    2011-03-11

    ... of the Upper Hack Bridge at mile 6.9, across the Hackensack River, at Secaucus, New Jersey. The..., Docket Operations, telephone 202-366-9826. SUPPLEMENTARY INFORMATION: The Upper Hack Bridge, across the.... Under this temporary deviation the Upper Hack Bridge, mile 6.9, across the Hackensack River may remain...

  12. 78 FR 15879 - Drawbridge Operation Regulations; Sacramento River, Sacramento, CA

    Science.gov (United States)

    2013-03-13

    ... community to participate in the First Annual ``Biggest Loser'' 5K walk and run event. This deviation allows..., Program Manager, Docket Operations, telephone 202-366-9826. SUPPLEMENTARY INFORMATION: The California... 16, 2013, to allow the community to participate in the First Annual ``Biggest Loser'' 5K walk and run...

  13. 75 FR 10172 - Drawbridge Operation Regulation; Chester River, Chestertown, MD

    Science.gov (United States)

    2010-03-05

    ...., specifications of materials, performance, design, or operation; test methods; sampling procedures; and related... they could better evaluate its effects on them and participate in the rulemaking process. Small... under Executive Order 13132, Federalism, if it has a substantial direct effect on State or local...

  14. 75 FR 30747 - Drawbridge Operation Regulation; Curtis Creek, Baltimore, MD

    Science.gov (United States)

    2010-06-02

    ... mean high water. The City of Baltimore is installing six video cameras on the bridge to enhance the... video cameras, audio system, or phone communications, the Pennington Avenue Bridge would not be operated... prolonged blast followed by one short blast to warn of bridge movement. The channel traffic lights will...

  15. Research vessels

    Digital Repository Service at National Institute of Oceanography (India)

    Rao, P.S.

    by the research vessels RV Gaveshani and ORV Sagar Kanya are reported. The work carried out by the three charted ships is also recorded. A short note on cruise plans for the study of ferromanganese nodules is added...

  16. 50 CFR 216.24 - Taking and related acts incidental to commercial fishing operations by tuna purse seine vessels...

    Science.gov (United States)

    2010-10-01

    ... from the backdown channel apex to the stern tiedown point. The dolphin safety panel must consist of... that begins at the outboard end of the last bow bunch pulled and continues to at least two-thirds the distance from the backdown channel apex to the stern tiedown point. (7) Experimental fishing operations...

  17. 77 FR 19565 - Additional Changes to the Schedule of Operations Regulations

    Science.gov (United States)

    2012-04-02

    ... rule to amend the meat and poultry products regulations pertaining to the schedule of operations. The... SW., Room 8-163A, Washington, DC 20250-3700. Instructions: All items submitted by mail or electronic...

  18. LANL Robotic Vessel Scanning

    Energy Technology Data Exchange (ETDEWEB)

    Webber, Nels W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-11-25

    Los Alamos National Laboratory in J-1 DARHT Operations Group uses 6ft spherical vessels to contain hazardous materials produced in a hydrodynamic experiment. These contaminated vessels must be analyzed by means of a worker entering the vessel to locate, measure, and document every penetration mark on the vessel. If the worker can be replaced by a highly automated robotic system with a high precision scanner, it will eliminate the risks to the worker and provide management with an accurate 3D model of the vessel presenting the existing damage with the flexibility to manipulate the model for better and more in-depth assessment.The project was successful in meeting the primary goal of installing an automated system which scanned a 6ft vessel with an elapsed time of 45 minutes. This robotic system reduces the total time for the original scope of work by 75 minutes and results in excellent data accumulation and transmission to the 3D model imaging program.

  19. Down-regulation of miR-101 in endothelial cells promotes blood vessel formation through reduced repression of EZH2.

    Directory of Open Access Journals (Sweden)

    Michiel Smits

    2011-01-01

    Full Text Available Angiogenesis is a balanced process controlled by pro- and anti-angiogenic molecules of which the regulation is not fully understood. Besides classical gene regulation, miRNAs have emerged as post-transcriptional regulators of angiogenesis. Furthermore, epigenetic changes caused by histone-modifying enzymes were shown to modulate angiogenesis as well. However, a possible interplay between miRNAs and histone-modulating enzymes during angiogenesis has not been described. Here we show that VEGF-mediated down-regulation of miR-101 caused pro-angiogenic effects. We found that the pro-angiogenic effects are partly mediated through reduced repression by miR-101 of the histone-methyltransferase EZH2, a member of the Polycomb group family, thereby increasing methylation of histone H3 at lysine 27 and transcriptome alterations. In vitro, the sprouting and migratory properties of primary endothelial cell cultures were reduced by inhibiting EZH2 through up-regulation of miR-101, siRNA-mediated knockdown of EZH2, or treatment with 3-Deazaneplanocin-A (DZNep, a small molecule inhibitor of EZH2 methyltransferase activity. In addition, we found that systemic DZNep administration reduced the number of blood vessels in a subcutaneous glioblastoma mouse model, without showing adverse toxicities. Altogether, by identifying a pro-angiogenic VEGF/miR-101/EZH2 axis in endothelial cells we provide evidence for a functional link between growth factor-mediated signaling, post-transcriptional silencing, and histone-methylation in the angiogenesis process. Inhibition of EZH2 may prove therapeutic in diseases in which aberrant vascularization plays a role.

  20. 76 FR 14804 - Drawbridge Operation Regulations; Annisquam River and Blynman Canal, Gloucester, MA

    Science.gov (United States)

    2011-03-18

    ... necessary to facilitate a public event, the Yucan One- Mile Road Race, which will cross the SR127 Bridge... a temporary deviation from the regulations to facilitate the Yucan One-Mile Road Race which will... operating regulations is authorized under 33 CFR 117.35. Dated: March 8, 2011. Gary Kassof, Bridge Program...

  1. 77 FR 70372 - Drawbridge Operation Regulation; Shark River (South Channel), Avon Township, NJ

    Science.gov (United States)

    2012-11-26

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Shark River (South..., across Shark River (South Channel) at Avon Township, NJ. The existing regulation contains a drawbridge... Transportation (NJDOT) to replace the existing bascule bridge, which carries S35 over Shark River (South Channel...

  2. Agriculture: Laws and Regulations that Apply to Your Agricultural Operation by Farm Activity

    Science.gov (United States)

    A general description of EPA’s requirements applicable to agriculture, and should only be used as a guide. Since rules and regulations may change use this information is a starting place to determine which regulations apply to your agricultural operation.

  3. [Prevalence and influence of risk factors on coronary shunting operations in patients with aterosclerosis of abdominal aorta and peripheral vessels].

    Science.gov (United States)

    Konstantinov, B A; Bazylev, V V; Belov, Iu V; Kizyma, A G

    2008-01-01

    Retrospective study analysis concerning the prevalence of risk factors for unfavorable outcomes after coronary operations in patients with peripheral arterial atherosclerosis is presented. Meta-analysis of individual risk factors was carried out. Frequency of complications after coronary shunting in patients with various concomitant diseases is evaluated. The multifactorial relative risk affecting hospital lethality is defined. The study includes 131 patients with generalized atherosclerosis, which have underwent myocardial revascularization at the first stage (the main group) and at the second stage have been operated on abdominal aorta and peripheral arteries. 1128 patients without peripheral arterial atherosclerosis have made the control group. They underwent only coronary shunting. All patients were treated from December of 1994 till June of 2006. Relying on the results of the study cumulative relative risk for unfavorable outcomes after revascularization is 1.8 times higher in patients from the main group than in patients from the control group, and the risk for primary complications is 2.03 times higher. Concomitant atherosclerotic arterial involvement among cardiosurgical patients is associated with high risk for stroke in postoperative period. In case of chronic renal failure risk factors are cumulated. In the main group lethality made 5% , which was higher as compared with the control group. Correlation of such risk factors as heart failure and renal failure (creatinine level more than 1.8 mg/dl) with lethality has been revealed among patients from the main group. Lethality risk raises in 5.30 times in the presence of heart failure in medical history, and raises in 13.15 times in case of initially elevated creatinine level. Age of patient didn't have any influence on lethality in early postoperative period.

  4. 78 FR 18933 - Drawbridge Operation Regulations; Upper Mississippi River, Rock Island, IL

    Science.gov (United States)

    2013-03-28

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Upper Mississippi River, Rock Island... Coast Guard has issued a temporary deviation from the operating schedule that governs the Rock Island Railroad and Highway Drawbridge across the Upper Mississippi River, mile 482.9, at Rock Island, Illinois...

  5. 75 FR 17561 - Drawbridge Operation Regulations; Upper Mississippi River, Rock Island, IL

    Science.gov (United States)

    2010-04-07

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Upper Mississippi River, Rock Island... operations of the Rock Island Railroad and Highway Drawbridge across the Upper Mississippi River, Mile 482.9, Rock Island, Illinois. The deviation is necessary to allow the Quad Cities Heart Walkers to cross the...

  6. 75 FR 81125 - Drawbridge Operation Regulation; Upper Mississippi River, Rock Island, IL

    Science.gov (United States)

    2010-12-27

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Upper Mississippi River, Rock Island... operation of the Crescent Railroad Drawbridge across the Upper Mississippi River, mile 481.4, at Rock Island... Railroad Drawbridge, across the Upper Mississippi River, mile 481.4, at Rock Island, Illinois to open on...

  7. 75 FR 66306 - Drawbridge Operation Regulation; Arkansas Waterway, Little Rock, AR

    Science.gov (United States)

    2010-10-28

    ..., Little Rock, AR AGENCY: Coast Guard, DHS. ACTION: Final rule. SUMMARY: Drawbridge operations for the Baring Cross Railroad Drawbridge across the Arkansas Waterway at Mile 119.6 at Little Rock, Arkansas... (NPRM) entitled Drawbridge Operation Regulation; Arkansas Waterway, Little ] Rock, AR in the Federal...

  8. 77 FR 3607 - Drawbridge Operation Regulation; Upper Mississippi River, Rock Island, IL

    Science.gov (United States)

    2012-01-25

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Upper Mississippi River, Rock Island... operation of the Rock Island Railroad and Highway Drawbridge across the Upper Mississippi River, mile 482.9, at Rock Island, Illinois. The deviation is necessary to allow the Quad Cities Heart Walk to cross the...

  9. 78 FR 21537 - Drawbridge Operation Regulations; Upper Mississippi River, Rock Island, IL

    Science.gov (United States)

    2013-04-11

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Upper Mississippi River, Rock Island... Coast Guard has issued a temporary deviation from the operating schedule that governs the Rock Island Railroad and Highway Drawbridge across the Upper Mississippi River, mile 482.9, at Rock Island, Illinois...

  10. 75 FR 68974 - Drawbridge Operation Regulation; Upper Mississippi River, Rock Island, IL

    Science.gov (United States)

    2010-11-10

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Upper Mississippi River, Rock Island... operation of the Rock Island Railroad and Highway Drawbridge across the Upper Mississippi River, mile 482.9, at Rock Island, Illinois. The deviation is necessary to allow the bridge owner time to perform...

  11. 78 FR 16411 - Drawbridge Operation Regulation; Upper Mississippi River, Rock Island, IL

    Science.gov (United States)

    2013-03-15

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Upper Mississippi River, Rock Island... Coast Guard has issued a temporary deviation from the operating schedule that governs the Rock Island Railroad and Highway Drawbridge across the Upper Mississippi River, mile 482.9, at Rock Island, Illinois...

  12. 78 FR 15292 - Drawbridge Operation Regulations; Upper Mississippi River, Rock Island, IL

    Science.gov (United States)

    2013-03-11

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Upper Mississippi River, Rock Island... has issued a temporary deviation from the operating schedule that governs the Rock Island Railroad and Highway Drawbridge, across the Upper Mississippi River, mile 482.9, at Rock Island, Illinois. The...

  13. 78 FR 79312 - Drawbridge Operation Regulation; Upper Mississippi River, Rock Island, IL

    Science.gov (United States)

    2013-12-30

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Upper Mississippi River, Rock Island... Coast Guard has issued a temporary deviation from the operating schedule that governs the Rock Island Railroad and Highway Drawbridge across the Upper Mississippi River, mile 482.9, at Rock Island, Illinois...

  14. 76 FR 9224 - Drawbridge Operation Regulation; Upper Mississippi River, Rock Island, IL

    Science.gov (United States)

    2011-02-17

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Upper Mississippi River, Rock Island... operation of the Rock Island Railroad and Highway Drawbridge across the Upper Mississippi River, mile 482.9, at Rock Island, Illinois. The deviation is necessary to allow the Quad Cities Heart Walk to cross the...

  15. 77 FR 5398 - Drawbridge Operation Regulation; Upper Mississippi River, Rock Island, IL

    Science.gov (United States)

    2012-02-03

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Upper Mississippi River, Rock Island... operation of the Rock Island Railroad and Highway Drawbridge across the Upper Mississippi River, mile 482.9, at Rock Island, Illinois. The deviation is necessary to allow the Quad City Marathon to cross the...

  16. 78 FR 69995 - Drawbridge Operation Regulation; Upper Mississippi River, Rock Island, IL

    Science.gov (United States)

    2013-11-22

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Upper Mississippi River, Rock Island... Coast Guard has issued a temporary deviation from the operating schedule that governs the Rock Island Railroad and Highway Drawbridge across the Upper Mississippi River, mile 482.9, at Rock Island, Illinois...

  17. 76 FR 9223 - Drawbridge Operation Regulation; Upper Mississippi River, Rock Island, IL

    Science.gov (United States)

    2011-02-17

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Upper Mississippi River, Rock Island... operation of the Rock Island Railroad and Highway Drawbridge across the Upper Mississippi River, mile 482.9, at Rock Island, Illinois. The deviation is necessary to allow the Quad City Marathon to cross the...

  18. 75 FR 22228 - Drawbridge Operation Regulations; Upper Mississippi River, Rock Island, IL

    Science.gov (United States)

    2010-04-28

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Upper Mississippi River, Rock Island... operation of the Rock Island Railroad and Highway Drawbridge across the Upper Mississippi River, Mile 482.9, Rock Island, Illinois. The deviation is necessary to allow the Quad Cities Marathon to cross the bridge...

  19. 77 FR 20716 - Drawbridge Operation Regulation; Upper Mississippi River, Rock Island, IL

    Science.gov (United States)

    2012-04-06

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Upper Mississippi River, Rock Island... operation of the Rock Island Railroad and Highway Drawbridge across the Upper Mississippi River, mile 482.9, at Rock Island, Illinois. The deviation is necessary to allow the Quad Cities Live Uncommon Walk to...

  20. 75 FR 12688 - Drawbridge Operation Regulations; Long Island, New York Inland Waterway from East Rockaway Inlet...

    Science.gov (United States)

    2010-03-17

    ... issued a temporary deviation from the regulation governing the operation of the Wreck Lead Railroad..., Program Manager, Docket Operations, telephone 202-366-9826. SUPPLEMENTARY INFORMATION: The Wreck Lead... motor locks. Under this deviation the Wreck Lead Railroad Bridge may remain closed from 9 a.m. through 3...

  1. 76 FR 75836 - Revisions to Distilled Spirits Plant Operations Reports and Regulations

    Science.gov (United States)

    2011-12-05

    ... submissions, such as excise tax returns. These changes would improve the efficiency of operations within TTB... Alcohol and Tobacco Tax and Trade Bureau 27 CFR Part 19 RIN 1513-AB89 Revisions to Distilled Spirits Plant Operations Reports and Regulations AGENCY: Alcohol and Tobacco Tax and Trade Bureau, Treasury. ACTION: Notice...

  2. 76 FR 11679 - Drawbridge Operation Regulation; Shark River (South Channel), Belmar, NJ

    Science.gov (United States)

    2011-03-03

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Shark River (South Channel), Belmar... operation of the S71 Bridge across Shark River (South Channel), mile 0.8, at Belmar, NJ. The deviation is... INFORMATION: The S71 Bridge, a bascule lift drawbridge, across Shark River (South Channel), at mile 0.8, in...

  3. 76 FR 45690 - Drawbridge Operation Regulation; Raritan River, Arthur Kill and Their Tributaries, Staten Island...

    Science.gov (United States)

    2011-08-01

    ... Kill and Their Tributaries, Staten Island, NY and Elizabeth, NJ AGENCY: Coast Guard, DHS. ACTION: Final... operation of the Arthur Kill (AK) Railroad Bridge at mile 11.6, across Arthur Kill between Staten Island... proposed rulemaking (NPRM) entitled Drawbridge Operation Regulations Raritan River, Arthur Kill and their...

  4. 78 FR 64887 - Drawbridge Operation Regulation; Upper Mississippi River, Hannibal, MO

    Science.gov (United States)

    2013-10-30

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Upper Mississippi River, Hannibal, MO... Guard has issued a temporary deviation from the operating schedule that governs the Hannibal Railroad Drawbridge across the Upper Mississippi River, mile 309.9, at Hannibal, Missouri. The deviation is necessary...

  5. 77 FR 28488 - Drawbridge Operation Regulation; Upper Mississippi River, Hannibal, MO

    Science.gov (United States)

    2012-05-15

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Upper Mississippi River, Hannibal, MO... Guard has issued a temporary deviation from the operating schedule that governs the Hannibal Railroad Drawbridge across the Upper Mississippi River, mile 309.9, at Hannibal, Missouri. The deviation is necessary...

  6. Vessel Permit System Data Set

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — GARFO issues federal fishing permits annually to owners of fishing vessels who fish in the Greater Atlantic region, as required by federal regulation. These permits...

  7. Compliance with vessel speed restrictions to protect North Atlantic right whales

    Directory of Open Access Journals (Sweden)

    Gregory K. Silber

    2014-06-01

    Full Text Available Environmental regulations can only be effective if they are adhered to, but the motivations for regulatory compliance are not always clear. We assessed vessel operator compliance with a December 2008 regulation aimed at reducing collisions with the endangered North Atlantic right whale that requires vessels 65 feet or greater in length to travel at speeds of 10 knots or less at prescribed times and locations along the U.S. eastern seaboard. Extensive outreach efforts were undertaken to notify affected entities both before and after the regulation went into effect. Vessel speeds of 201,862 trips made between November 2008 and August 2013 by 8,009 individual vessels were quantified remotely, constituting a nearly complete census of transits made by the regulated population. Of these, 437 vessels (or their parent companies, some of whom had been observed exceeding the speed limit, were contacted through one of four non-punitive information programs. A fraction (n = 26 vessels/companies received citations and fines. Despite the efforts to inform mariners, initial compliance was low (<5% of the trips were completely <10 knots but improved in the latter part of the study. Each notification/enforcement program improved compliance to some degree and some may have influenced compliance across the entire regulated community. Citations/fines appeared to have the greatest influence on improving compliance in notified vessels/companies, followed in order of effectiveness by enforcement-office information letters, monthly summaries of vessel operations, and direct at-sea radio contact. Trips by cargo vessels exhibited the greatest change in behavior followed by tanker and passenger vessels. These results have application to other regulatory systems, especially where remote monitoring is feasible, and any setting where regulatory compliance is sought.

  8. Southeast Region Headboat Survey-Vessel list/Vessel Directory

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This is a database of vessels that have been on the SRHS through time, their owners/operators, marinas/docks and their contact information. This assists in...

  9. 46 CFR 535.312 - Vessel charter party-exemption.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Vessel charter party-exemption. 535.312 Section 535.312... Vessel charter party-exemption. (a) For purposes of this section, vessel charter party shall mean a... operational limitations, if any) under which the vessel will be employed. (b) Vessel charter parties, as...

  10. Compliance with regulations by "swim-with-dolphins" operations in Port Phillip Bay, Victoria, Australia.

    Science.gov (United States)

    Scarpaci, Carol; Dayanthi, Nugegoda; Corkeron, Peter J

    2003-03-01

    Managing the activities of commercial wildlife viewing tends to involve either restricting the number of industry participants and/or regulating the activities or industry participants. We report on operator compliance with regulations regarding humans swimming with free-ranging bottlenose dolphins ( Tursiops sp.) in Port Phillip Bay, Victoria, Australia. A total of 128 commercial dolphin-swim trips was studied between September 1998 and April 2000. Four permit conditions were investigated: approach type, swim time, time in proximity of dolphins, and presence of "fetal fold" calves. Results demonstrate noncompliance by operators to all of the four permit conditions studied. Compliance with temporal conditions was poorer than with other conditions. When conducting studies on the extent to which tourism affects cetaceans, investigators should consider whether tourist operations comply with existing regulations or guidelines.

  11. An Improved Multi-Objective Artificial Bee Colony Optimization Algorithm with Regulation Operators

    Directory of Open Access Journals (Sweden)

    Jiuyuan Huo

    2017-02-01

    Full Text Available To achieve effective and accurate optimization for multi-objective optimization problems, a multi-objective artificial bee colony algorithm with regulation operators (RMOABC inspired by the intelligent foraging behavior of honey bees was proposed in this paper. The proposed algorithm utilizes the Pareto dominance theory and takes advantage of adaptive grid and regulation operator mechanisms. The adaptive grid technique is used to adaptively assess the Pareto front maintained in an external archive and the regulation operator is used to balance the weights of the local search and the global search in the evolution of the algorithm. The performance of RMOABC was evaluated in comparison with other nature inspired algorithms includes NSGA-II and MOEA/D. The experiments results demonstrated that the RMOABC approach has better accuracy and minimal execution time.

  12. Toward Better Mapping between Regulations and Operations of Enterprises Using Vocabularies and Semantic Similarity

    Directory of Open Access Journals (Sweden)

    Sagar Sunkle

    2015-12-01

    Full Text Available Industry governance, risk, and compliance (GRC solutions stand to gain from various analyses offered by formal compliance checking approaches. Such adoption is made difficult by the fact that most formal approaches assume that a mapping between concepts of regulations and models of operational specifics exists. Industry solutions offer tagging mechanisms to map regulations to operational specifics; however, they are mostly semi-formal in nature and tend to rely extensively on experts. We propose to use Semantics of Business Vocabularies and Rules along with similarity measures to create an explicit mapping between concepts of regulations and models of operational specifics of the enterprise. We believe that our work-in-progress takes a step toward adapting and leveraging formal compliance checking approaches in industry GRC solutions.

  13. Vessel segmentation in screening mammograms

    Science.gov (United States)

    Mordang, J. J.; Karssemeijer, N.

    2015-03-01

    Blood vessels are a major cause of false positives in computer aided detection systems for the detection of breast cancer. Therefore, the purpose of this study is to construct a framework for the segmentation of blood vessels in screening mammograms. The proposed framework is based on supervised learning using a cascade classifier. This cascade classifier consists of several stages where in each stage a GentleBoost classifier is trained on Haar-like features. A total of 30 cases were included in this study. In each image, vessel pixels were annotated by selecting pixels on the centerline of the vessel, control samples were taken by annotating a region without any visible vascular structures. This resulted in a total of 31,000 pixels marked as vascular and over 4 million control pixels. After training, the classifier assigns a vesselness likelihood to the pixels. The proposed framework was compared to three other vessel enhancing methods, i) a vesselness filter, ii) a gaussian derivative filter, and iii) a tubeness filter. The methods were compared in terms of area under the receiver operating characteristics curves, the Az values. The Az value of the cascade approach is 0:85. This is superior to the vesselness, Gaussian, and tubeness methods, with Az values of 0:77, 0:81, and 0:78, respectively. From these results, it can be concluded that our proposed framework is a promising method for the detection of vessels in screening mammograms.

  14. 50 CFR 660.305 - Vessel identification.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Vessel identification. 660.305 Section 660.305 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Fisheries § 660.305 Vessel identification. (a) Display. The operator of a vessel that is over 25 ft (7.6 m...

  15. Compliance with vessel speed restrictions to protect North Atlantic right whales

    Science.gov (United States)

    Adams, Jeffrey D.; Fonnesbeck, Christopher J.

    2014-01-01

    Environmental regulations can only be effective if they are adhered to, but the motivations for regulatory compliance are not always clear. We assessed vessel operator compliance with a December 2008 regulation aimed at reducing collisions with the endangered North Atlantic right whale that requires vessels 65 feet or greater in length to travel at speeds of 10 knots or less at prescribed times and locations along the U.S. eastern seaboard. Extensive outreach efforts were undertaken to notify affected entities both before and after the regulation went into effect. Vessel speeds of 201,862 trips made between November 2008 and August 2013 by 8,009 individual vessels were quantified remotely, constituting a nearly complete census of transits made by the regulated population. Of these, 437 vessels (or their parent companies), some of whom had been observed exceeding the speed limit, were contacted through one of four non-punitive information programs. A fraction (n = 26 vessels/companies) received citations and fines. Despite the efforts to inform mariners, initial compliance was low (tanker and passenger vessels. These results have application to other regulatory systems, especially where remote monitoring is feasible, and any setting where regulatory compliance is sought. PMID:24949229

  16. 76 FR 79145 - Drawbridge Operation Regulations; Bayou Liberty, Mile 2.0, St. Tammany Parish, Slidell, LA

    Science.gov (United States)

    2011-12-21

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulations; Bayou Liberty, Mile 2... operation of the SR 433 Bridge over Bayou Liberty, mile 2.0, St. Tammany Parish, Slidell, LA. The Louisiana... Notice of Proposed Rulemaking (NPRM) entitled ``Drawbridge Operation Regulations; Bayou Liberty, mile 2.0...

  17. 75 FR 68704 - Drawbridge Operation Regulations; Hackensack River, Jersey City, NJ

    Science.gov (United States)

    2010-11-09

    ... District, has issued a temporary deviation from the regulation governing the operation of the Upper Hack...-9826. SUPPLEMENTARY INFORMATION: The Upper Hack Bridge, across the Hackensack River at mile 6.9 has a... the bridge. Under this temporary deviation the Upper Hack Bridge, mile 6.9, across the Hackensack...

  18. 78 FR 27336 - Drawbridge Operation Regulation; Wolf River, Gills Landing and Winneconne, WI

    Science.gov (United States)

    2013-05-10

    ... 2.4, and the Canadian National Railroad Bridge at mile 27.8, both over the Wolf River. A review of... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulation; Wolf River, Gills... Canadian National Railroad. DATES: Comments and related material must reach the Coast Guard on or before...

  19. 78 FR 76195 - Drawbridge Operation Regulations; Passaic River, Newark and Harrison, NJ

    Science.gov (United States)

    2013-12-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Passaic River, Newark and Harrison..., mile 5.0, between Newark and Harrison, New Jersey. This deviation allows the AMTRACK Dock Bridge, mile...

  20. 75 FR 63713 - Drawbridge Operation Regulation; Back Bay of Biloxi, Harrison County, MS

    Science.gov (United States)

    2010-10-18

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Back Bay of Biloxi, Harrison County...'Iberville, Harrison County, Mississippi. This deviation is necessary to allow timely bridge rehabilitation... D'Iberville, Harrison County, Mississippi, has a vertical clearance of 60 feet above mean high water...

  1. 76 FR 16296 - Drawbridge Operation Regulation; Pocomoke River, Snow Hill, MD

    Science.gov (United States)

    2011-03-23

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Pocomoke River, Snow Hill, MD AGENCY... the S12 Bridge across Pocomoke River, mile 29.9, at Snow Hill, MD. The deviation restricts the... least five hours advance notice is given. The S12 Bridge across Pocomoke River, mile 29.9 at Snow Hill...

  2. 75 FR 52461 - Drawbridge Operation Regulation; Pocomoke River, Snow Hill, MD

    Science.gov (United States)

    2010-08-26

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Pocomoke River, Snow Hill, MD AGENCY... the S12 ] Bridge across the Pocomoke River, mile 29.9, at Snow Hill, MD. The deviation restricts the... hours advance notice is given. The S12 Bridge across Pocomoke River, mile 29.9 at Snow Hill MD, has a...

  3. 75 FR 30299 - Drawbridge Operation Regulations; Newtown Creek, Dutch Kills, English Kills, and Their...

    Science.gov (United States)

    2010-06-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Newtown Creek, Dutch Kills, English Kills, and Their Tributaries, NY, Maintenance AGENCY: Coast Guard, DHS. ACTION: Notice of temporary...

  4. 75 FR 62469 - Drawbridge Operation Regulations; Newtown Creek, Dutch Kills, English Kills, and Their...

    Science.gov (United States)

    2010-10-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Newtown Creek, Dutch Kills, English Kills, and Their Tributaries, NY, Maintenance AGENCY: Coast Guard, DHS. ACTION: Notice of temporary...

  5. 49 CFR 220.43 - Radio communications consistent with federal regulations and railroad operating rules.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Radio communications consistent with federal... Radio and Wireless Communication Procedures § 220.43 Radio communications consistent with federal regulations and railroad operating rules. Radio communication shall not be used in connection with a railroad...

  6. 77 FR 56115 - Drawbridge Operation Regulations; Fort Point Channel, Boston, MA

    Science.gov (United States)

    2012-09-12

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Fort Point Channel, Boston, MA... of the Northern Avenue Bridge, mile 0.1, across the Fort Point Channel, at Boston, Massachusetts...: The Northern Avenue Bridge, across the Fort Point Channel, mile 0.1, has a vertical clearance in the...

  7. 77 FR 6465 - Drawbridge Operation Regulations; Connecticut River, Old Lyme, CT

    Science.gov (United States)

    2012-02-08

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Connecticut River, Old Lyme, CT... of the Old Saybrook-Old Lyme RR Bridge, mile 3.4, across the Connecticut River at Old Lyme... INFORMATION: The Old Saybrook-Old Lyme RR Bridge at mile 3.4, across the Connecticut River at Old Lyme...

  8. 76 FR 35978 - Drawbridge Operation Regulations; Connecticut River, Old Lyme, CT

    Science.gov (United States)

    2011-06-21

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Connecticut River, Old Lyme, CT... of the Amtrak Railroad Bridge at mile 3.4, across the Connecticut River at Old Lyme, Connecticut. The... INFORMATION: The Amtrak Railroad Bridge, across the Connecticut River at mile 3.4, at Old Lyme, Connecticut...

  9. 76 FR 16715 - Drawbridge Operation Regulation; Raritan River, Arthur Kill and Their Tributaries, Staten Island...

    Science.gov (United States)

    2011-03-25

    ... Kill and Their Tributaries, Staten Island, NY and Elizabeth, NJ AGENCY: Coast Guard, DHS. ACTION... regulations governing the operation of the Arthur Kill (AK) Railroad Bridge at mile 11.6, across Arthur Kill... Kill (AK) Railroad Bridge at mile 11.6, across Arthur Kill, has a vertical clearance of 31 feet at mean...

  10. 75 FR 76632 - Drawbridge Operation Regulation; Upper Mississippi River, Hannibal, MO

    Science.gov (United States)

    2010-12-09

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Upper Mississippi River, Hannibal, MO... of the Hannibal Railroad Drawbridge across the Upper Mississippi River, mile 309.9, at Hannibal.... SUPPLEMENTARY INFORMATION: The Norfolk Southern Railroad requested a temporary deviation for the Hannibal...

  11. 78 FR 18480 - Drawbridge Operation Regulations; Chef Menteur Pass, at Lake Catherine, LA

    Science.gov (United States)

    2013-03-27

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Chef Menteur Pass, at Lake Catherine.... Highway 90 swing highway bridge across the Chef Menteur Pass, mile 2.8, at Lake Catherine, Orleans Parish... approved the request for the closure of the U.S. Highway 90 swing bridge crossing the Chef Menteur Pass...

  12. 78 FR 72817 - Drawbridge Operation Regulation; Chef Menteur Pass, New Orleans, LA

    Science.gov (United States)

    2013-12-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulation; Chef Menteur Pass, New Orleans, LA... across Chef Menteur Pass, mile 2.8, at New Orleans, Orleans Parish, Louisiana. The deviation is necessary...

  13. 33 CFR 401.67 - Explosive vessels.

    Science.gov (United States)

    2010-07-01

    ... TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Dangerous Cargo § 401.67 Explosive vessels. A vessel carrying explosives, either Government or commercial, as defined in the Dangerous Cargo Act of the United States and in the International Maritime Dangerous Goods Code, Class 1, Divisions 1.1 to 1.5 inclusive...

  14. Simulated Microgravity Regulates Gene Transcript Profiles of 2T3 Preosteoblasts: Comparison of the Random Positioning Machine and the Rotating Wall Vessel Bioreactor

    Science.gov (United States)

    Patel, Mamta J.; Liu, Wenbin; Sykes, Michelle C.; Ward, Nancy E.; Risin, Semyon A.; Risin, Diana; Hanjoong, Jo

    2007-01-01

    Microgravity of spaceflight induces bone loss due in part to decreased bone formation by osteoblasts. We have previously examined the microgravity-induced changes in gene expression profiles in 2T3 preosteoblasts using the Random Positioning Machine (RPM) to simulate microgravity conditions. Here, we hypothesized that exposure of preosteoblasts to an independent microgravity simulator, the Rotating Wall Vessel (RWV), induces similar changes in differentiation and gene transcript profiles, resulting in a more confined list of gravi-sensitive genes that may play a role in bone formation. In comparison to static 1g controls, exposure of 2T3 cells to RWV for 3 days inhibited alkaline phosphatase activity, a marker of differentiation, and downregulated 61 genes and upregulated 45 genes by more than two-fold as shown by microarray analysis. The microarray results were confirmed with real time PCR for downregulated genes osteomodulin, bone morphogenic protein 4 (BMP4), runx2, and parathyroid hormone receptor 1. Western blot analysis validated the expression of three downregulated genes, BMP4, peroxiredoxin IV, and osteoglycin, and one upregulated gene peroxiredoxin I. Comparison of the microarrays from the RPM and the RWV studies identified 14 gravi-sensitive genes that changed in the same direction in both systems. Further comparison of our results to a published database showing gene transcript profiles of mechanically loaded mouse tibiae revealed 16 genes upregulated by the loading that were shown to be downregulated by RWV and RPM. These mechanosensitive genes identified by the comparative studies may provide novel insights into understanding the mechanisms regulating bone formation and potential targets of countermeasure against decreased bone formation both in astronauts and in general patients with musculoskeletal disorders.

  15. 46 CFR 169.307 - Plans for sister vessels.

    Science.gov (United States)

    2010-10-01

    ... Construction and Arrangement Plans § 169.307 Plans for sister vessels. Plans are not required for any vessel which is a sister ship to a vessel, provided that— (a) The approved plans for the original vessels are... new construction; (c) The regulations have not changed since the original plan approval; and (d) There...

  16. New research vessels

    Science.gov (United States)

    1984-04-01

    Two “new” ocean-going research vessels operated by the Scripps Institution of Oceanography and the National Science Foundation (NSF) will soon begin full-time scientific duties off the coast of California and in the Antarctic, respectively. The 37.5-m Scripps vessel, named Robert Gordon Sprout in honor of the ex-president of the University of California, replaces the smaller ship Ellen B. Scripps, which had served the institution since 1965. The new ship is a slightly modified Gulf Coast workboat. Under the name of Midnight Alaskan, it had been used for high-resolution geophysical surveys in American and Latin American waters by such firms as Arco Oil & Gas, Exxon, Pennzoil, and Racal-Decca before its purchase by Scripps from a Lousiana chartering firm last summer.

  17. Operative nuances to safeguard anomalous vertebral artery without compromising the surgery for congenital atlantoaxial dislocation: untying a tough knot between vessel and bone.

    Science.gov (United States)

    Salunke, Pravin; Futane, Sameer; Sahoo, Sushant K; Ghuman, Mandeep S; Khandelwal, Niranjan

    2014-01-01

    Stabilization of the craniovertebral junction (CVJ) by using lateral masses requires extensive dissection. The vertebral artery (VA) is commonly anomalous in patients with congenital CVJ anomaly. Such a vessel is likely to be injured during dissection or screw placement. In this study the authors discuss the importance of preoperative evaluation and certain intraoperative steps that reduce the chances of injury to such vessels. A 3D CT angiogram was obtained in 15 consecutive patients undergoing surgery for congenital atlantoaxial dislocation. The course of the VA and its relationship to the C1-2 facets was studied in these patients. The anomalous VA was exposed intraoperatively, facet surfaces were drilled in all, and the screws were placed according to the disposition of the vessel. A skeletal anomaly was found in all 10 patients who had an anomalous VA. Four types of variations were noted: 1) the first intersegmental artery in 5 patients (bilateral in 1); 2) fenestration of VA in 1 patient; 3) anomalous posterior inferior cerebellar artery crossing the C1-2 joint in 1 patient; and 4) medial loop of VA in 5 patients. The anomalous vessel was dissected and the facet surfaces were drilled in all. The C-1 lateral mass screw was placed under vision, taking care not to compromise the anomalous vessel, although occipital screws or sublaminar wires were used in the initial cases. A medial loop of the VA necessitated placement of transpedicular or C-2 lateral mass screws instead of pars interarticularis screws. The anomalous vessel was injured in none. Preoperative 3D CT angiography is a highly useful method of imaging the artery in patients with CVJ anomaly. It helps in identifying the anomalous VA or its branch and its relationship to the C1-2 facets. The normal side should be surgically treated and distracted first because this helps in opening the abnormal side, aiding in dissection. In the posterior approach the C-2 nerve root is always encountered before the

  18. The Efficiency of the Regulation for Horizontal Mergers Among Electricity Distribution Operators in Norway

    DEFF Research Database (Denmark)

    Agrell, Per J.; Bogetoft, Peter; Gammeltvedt, Thor Erik

    2015-01-01

    Merger analysis is usually drawing on concepts derived from competitive horizontal markets, such as market concentration, predatory foreclosure and economies of scale in marketing. In evaluating horizontal mergers among energy network operators, regulators must use different tools to evaluate...... the attractiveness of mergers. Norway is one country having implemented an ex ante regulation for mergers among electricity distribution operators (DSOs). We investigate whether the actual mergers of Norwegian DSOs in the period 1995-2004 can be rationalized as cost saving exercises or whether they should...... be interpreted in other ways. We use Data Envelopment Analysis (DEA) to estimate the potential cost savings from mergers ex ante, and we decompose the gains into gains from learning best practice and from improving economies of scale and scope. Moreover, we compare the sources of post merger performance...

  19. 76 FR 28311 - Drawbridge Operation Regulations; Bayou Liberty, Mile 2.0, St. Tammany Parish, Slidell, LA

    Science.gov (United States)

    2011-05-17

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Bayou Liberty, Mile 2.0, St. Tammany... deviation from the regulation governing the operation of the S433 Bridge over Bayou Liberty, mile 2.0, St... Bayou Liberty at mile 2.0, in St. Tammany Parish. The vertical clearance is 7.59 feet (2.31m) above the...

  20. 75 FR 71061 - Drawbridge Operation Regulations; Bayou Liberty, Mile 2.0, St. Tammany Parish, Slidell, LA

    Science.gov (United States)

    2010-11-22

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulations; Bayou Liberty, Mile 2... the regulation governing the operation of the S433 bridge over Bayou Liberty, mile 2.0, St. Tammany... of the S433 bridge over Bayou Liberty, mile 2.0, St. Tammany Parish, Slidell, LA. This change would...

  1. The TRPM7 channel kinase regulates store-operated calcium entry.

    Science.gov (United States)

    Faouzi, Malika; Kilch, Tatiana; Horgen, F David; Fleig, Andrea; Penner, Reinhold

    2017-05-15

    Pharmacological and molecular inhibition of transient receptor potential melastatin 7 (TRPM7) reduces store-operated calcium entry (SOCE). Overexpression of TRPM7 in TRPM7-/- cells restores SOCE. TRPM7 is not a store-operated calcium channel. TRPM7 kinase rather than channel modulates SOCE. TRPM7 channel activity contributes to the maintenance of store Ca2+ levels at rest. The transient receptor potential melastatin 7 (TRPM7) is a protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. In the present study, we report store-operated calcium entry (SOCE) as a novel target of TRPM7 kinase activity. TRPM7-deficient chicken DT40 B lymphocytes exhibit a strongly impaired SOCE compared to wild-type cells as a result of reduced calcium release activated calcium currents, and independently of potassium channel regulation, membrane potential changes or changes in cell-cycle distribution. Pharmacological blockade of TRPM7 with NS8593 or waixenicin A in wild-type B lymphocytes results in a significant decrease in SOCE, confirming that TRPM7 activity is acutely linked to SOCE, without TRPM7 representing a store-operated channel itself. Using kinase-deficient mutants, we find that TRPM7 regulates SOCE through its kinase domain. Furthermore, Ca2+ influx through TRPM7 is essential for the maintenance of endoplasmic reticulum Ca2+ concentration in resting cells, and for the refilling of Ca2+ stores after a Ca2+ signalling event. We conclude that the channel kinase TRPM7 and SOCE are synergistic mechanisms regulating intracellular Ca2+ homeostasis. © 2017 The Authors. The Journal of Physiology © 2017 The Physiological Society.

  2. Preparing Safety Cases for Operating Outside Prescriptive Fatigue Risk Management Regulations.

    Science.gov (United States)

    Gander, Philippa; Mangie, Jim; Wu, Lora; van den Berg, Margo; Signal, Leigh; Phillips, Adrienne

    2017-07-01

    Transport operators seeking to operate outside prescriptive fatigue management regulations are typically required to present a safety case justifying how they will manage the associated risk. This paper details a method for constructing a successful safety case. The method includes four elements: 1) scope (prescriptive rules and operations affected); 2) risk assessment; 3) risk mitigation strategies; and 4) monitoring ongoing risk. A successful safety case illustrates this method. It enables landing pilots in 3-pilot crews to choose the second or third in-flight rest break, rather than the regulatory requirement to take the third break. Scope was defined using a month of scheduled flights that would be covered (N = 4151). These were analyzed in the risk assessment using existing literature on factors affecting fatigue to estimate the maximum time awake at top of descent and sleep opportunities in each break. Additionally, limited data collected before the new regulations showed that pilots flying at landing chose the third break on only 6% of flights. A prospective survey comparing subjective reports (N = 280) of sleep in the second vs. third break and fatigue and sleepiness ratings at top of descent confirmed that the third break is not consistently superior. The safety case also summarized established systems for fatigue monitoring, risk assessment and hazard identification, and multiple fatigue mitigation strategies that are in place. Other successful safety cases have used this method. The evidence required depends on the expected level of risk and should evolve as experience with fatigue risk management systems builds.Gander P, Mangie J, Wu L, van den Berg M, Signal L, Phillips A. Preparing safety cases for operating outside prescriptive fatigue risk management regulations. Aerosp Med Hum Perform. 2017; 88(7):688-696.

  3. 29 CFR 1918.65 - Mechanically powered vehicles used aboard vessels.

    Science.gov (United States)

    2010-07-01

    ... ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR LONGSHORING Cargo Handling Gear and Equipment Other Than Ship's Gear § 1918.65 Mechanically powered vehicles used aboard vessels. (a... operator's view, and openings in the top of the guard shall not exceed six inches (15.24 cm) in one of the...

  4. Arianespace Launch Service Operator Policy for Space Safety (Regulations and Standards for Safety)

    Science.gov (United States)

    Jourdainne, Laurent

    2013-09-01

    Since December 10, 2010, the French Space Act has entered into force. This French Law, referenced as LOS N°2008-518 ("Loi relative aux Opérations Spatiales"), is compliant with international rules. This French Space Act (LOS) is now applicable for any French private company whose business is dealing with rocket launch or in orbit satellites operations. Under CNES leadership, Arianespace contributed to the consolidation of technical regulation applicable to launch service operators.Now for each launch operation, the operator Arianespace has to apply for an authorization to proceed to the French ministry in charge of space activities. In the files issued for this purpose, the operator is able to justify a high level of warranties in the management of risks through robust processes in relation with the qualification maintenance, the configuration management, the treatment of technical facts and relevant conclusions and risks reduction implementation when needed.Thanks to the historic success of Ariane launch systems through its more than 30 years of exploitation experience (54 successes in a row for latest Ariane 5 launches), Arianespace as well as European public and industrial partners developed key experiences and knowledge as well as competences in space security and safety. Soyuz-ST and Vega launch systems are now in operation from Guiana Space Center with identical and proved risks management processes. Already existing processes have been slightly adapted to cope with the new roles and responsibilities of each actor contributing to the launch preparation and additional requirements like potential collision avoidance with inhabited space objects.Up to now, more than 12 Ariane 5 launches and 4 Soyuz-ST launches have been authorized under the French Space Act regulations. Ariane 5 and Soyuz- ST generic demonstration of conformity have been issued, including exhaustive danger and impact studies for each launch system.This article will detail how Arianespace

  5. 78 FR 69803 - Drawbridge Operation Regulations; Gulf Intracoastal Waterway, Venice, FL

    Science.gov (United States)

    2013-11-21

    ... quarter-hour. C. Basis and Purpose The proposed changes will have a minor impact on vessels transiting the... it under those Orders. This action will have a minor impact on vessels transiting the Gulf... Constitutionally Protected Property Rights. 9. Civil Justice Reform This proposed rule meets applicable standards...

  6. Grounding Damage to Conventional Vessels

    DEFF Research Database (Denmark)

    Lützen, Marie; Simonsen, Bo Cerup

    2003-01-01

    regulations for design of bottom compartment layout with regard to grounding damages are largely based on statistical damage data. New and updated damage statistics holding 930 grounding accident records has been investigated. The bottom damage statistics is compared to current regulations for the bottom......The present paper is concerned with rational design of conventional vessels with regard to bottom damage generated in grounding accidents. The aim of the work described here is to improve the design basis, primarily through analysis of new statistical data for grounding damage. The current...... for the relation between the amount of deformed structure and the energy absorption. Finally, the paper shows how damage statistics for existing, conventional vessels can be used together with theoretical prediction methods for determining grounding damage distributions for new vessel types not included...

  7. Suggested Operation Grid-Connected Lithium-Ion Battery Energy Storage System for Primary Frequency Regulation

    DEFF Research Database (Denmark)

    Stroe, Daniel Ioan; Knap, Vaclav; Swierczynski, Maciej Jozef

    2015-01-01

    Because of their characteristics, which have been continuously improved during the last years, Lithium ion batteries were proposed as an alternative viable solution to present fast-reacting conventional generating units to deliver the primary frequency regulation service. However, even though...... there are worldwide demonstration projects where energy storage systems based on Lithium-ion batteries are evaluated for such applications, the field experience is still very limited. In consequence, at present there are no very clear requirements on how the Lithium-ion battery energy storage systems should...... be operated while providing frequency regulation service and how the system has to re-establish its SOC once the frequency event has passed. Therefore, this paper aims to investigate the effect on the lifetime of the Lithium-ion batteries energy storage system of various strategies for re...

  8. Operation of Grid -Connected Lithium-Ion Battery Energy Storage System for Primary Frequency Regulation

    DEFF Research Database (Denmark)

    Stroe, Daniel Loan; Knap, Vaclav; Swierczynski, Maciej Jozef

    2017-01-01

    Because of their characteristics, which have been continuously improved during the last years, Lithium ion batteries were proposed as an alternative viable solution to present fast-reacting conventional generating units to deliver the primary frequency regulation service. However, even though...... there are worldwide demonstration projects where energy storage systems based on Lithium-ion batteries are evaluated for such applications, the field experience is still very limited. In consequence, at present there are no very clear requirements on how the Lithium-ion battery energy storage systems should...... be operated while providing frequency regulation service and how the system has to re-establish its SOC once the frequency event has passed. Therefore, this paper aims to investigate the effect on the lifetime of the Lithium-ion batteries energy storage system of various strategies for re...

  9. Self-regulating passive fuel supply for small direct methanol fuel cells operating in all orientations

    Science.gov (United States)

    Paust, N.; Krumbholz, S.; Munt, S.; Müller, C.; Koltay, P.; Zengerle, R.; Ziegler, C.

    A microfluidic fuel supply concept for passive and portable direct methanol fuel cells (DMFCs) that operates in all spatial orientations is presented. The concept has been proven by fabricating and testing a passive DMFC prototype. Methanol transport at the anode is propelled by the surface energy of deformed carbon dioxide bubbles, generated as a reaction product during DMFC operation. The experimental study reveals that in any orientation, the proposed pumping mechanism transports at least 3.5 times more methanol to the reactive area of the DMFC than the stoichiometry of the methanol oxidation would require to sustain DMFC operation. Additionally, the flow rates closely follow the applied electric load; hence the pumping mechanism is self-regulating. Oxygen is supplied to the cathode by diffusion and the reaction product water is transported out of the fuel cell along a continuous capillary pressure gradient. Results are presented that demonstrate the continuous passive operation for more than 40 h at ambient temperature with a power output of p = 4 mW cm -2 in the preferred vertical orientation and of p = 3.2 mW cm -2 in the least favorable horizontal orientation with the anode facing downwards.

  10. 75 FR 32349 - Drawbridge Operation Regulation; Old River, Between Victoria Island and Byron Tract, CA

    Science.gov (United States)

    2010-06-08

    ....'' Click the ``Open Docket Folder'' in the ``Actions'' column. You may also visit the Docket Management... through July 2008 the Old River State Route 4 Drawbridge opened for vessels 42 times, an average of 3.5...

  11. [The special role of inducible NO-synthase in the mechanism of rat coronary vessels tone regulation during immobilization stress, combined with diabetes mellitus].

    Science.gov (United States)

    Lazuko, S S; Beliaeva, L E; Solodkov, A P

    2014-04-01

    Persistent hyperglycemia after intraperitoneal injection of streptozocin (50 mg/kg) to the rats prevents decrease of coronary vessels myogenic tone and myocardial contractility during subsequent 6-hr immobilization stress. The intensity of these abnormalities in all experimental groups is significantly reduced with the supplement of the perfusate with inducible NO-synthase (iNOS) selective blocker S-methylisothiourea. Similar rise of the NO2-/NO3- concentration in the rats' blood after "stress", "diabetes mellitus" and "diabetes mellitus + stress" combines with an increase of iNOS transcripts in the myocardium to 6, 5.8 and 51 times compared with control. These data testify to a substantial modification of the cells from coronary vessels in the presence of marked and persistent hyperglycemia. Inducible NO-synthase uncoupling caused by excessive formation of the reactive oxygen and nitrogen species in the myocardium may be one of number mechanisms responsible for such phenotypic vascular alteration in the "stress + diabetes mellitus" group.

  12. Contrast-enhanced magnetic resonance angiography for the detection of crossing renal vessels in children with symptomatic ureteropelvic junction obstruction: comparison with operative findings

    Energy Technology Data Exchange (ETDEWEB)

    Calder, Alistair D.; Hiorns, Melanie P.; Olsen, Oystein E. [Hospital for Children NHS Trust, Department of Radiology, London (United Kingdom); Abhyankar, Aruna; Mushtaq, Imran [Hospital for Children NHS Trust, Department of Urology, London (United Kingdom)

    2007-04-15

    Crossing renal vessels (CRV) are associated with ureteropelvic junction (UPJ) obstruction, particularly when presentation is beyond the neonatal period. Their presence may influence surgical management. To evaluate the accuracy of contrast-enhanced magnetic resonance angiography (CE-MRA) in the identification of CRV in children requiring surgical treatment of symptomatic UPJ obstruction, against a gold standard of laparoscopic or open surgical findings. We reviewed CE-MRA studies (3-D T2-weighted turbo spin-echo and multiphase 3-D spoiled gradient echo following intravenous gadolinium administration) of 14 children, age range 6-15 years, performed prior to surgery for suspected CRV-related UPJ obstruction. Consensus reviews of the CE-MRA studies were compared with surgical findings. CE-MRA demonstrated CRV at the level of the obstruction in nine and no crossing vessels in five children. These were all verified intraoperatively ({chi}{sup 2} = 14.0; P < 0.001). In eight of the nine patients with CRV there was no evidence of intrinsic obstruction at surgery. In the remaining patient there was fibrosis of the upper ureter. CE-MRA is an accurate means of identifying CRV in children older than 6 years with symptomatic UPJ obstruction. (orig.)

  13. 75 FR 68331 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; DFARS Part...

    Science.gov (United States)

    2010-11-05

    ... submit one copy of the rated on board vessel operating carrier's ocean bill of lading. Paragraph (f) of... provided. To confirm receipt of your comment(s), please check http://www.regulations.gov approximately two...

  14. Mechanosensing in developing lymphatic vessels.

    Science.gov (United States)

    Planas-Paz, Lara; Lammert, Eckhard

    2014-01-01

    The lymphatic vasculature is responsible for fluid homeostasis, transport of immune cells, inflammatory molecules, and dietary lipids. It is composed of a network of lymphatic capillaries that drain into collecting lymphatic vessels and ultimately bring fluid back to the blood circulation. Lymphatic endothelial cells (LECs) that line lymphatic capillaries present loose overlapping intercellular junctions and anchoring filaments that support fluid drainage. When interstitial fluid accumulates within tissues, the extracellular matrix (ECM) swells and pulls the anchoring filaments. This results in opening of the LEC junctions and permits interstitial fluid uptake. The absorbed fluid is then transported within collecting lymphatic vessels, which exhibit intraluminal valves that prevent lymph backflow and smooth muscle cells that sequentially contract to propel lymph.Mechanotransduction involves translation of mechanical stimuli into biological responses. LECs have been shown to sense and respond to changes in ECM stiffness, fluid pressure-induced cell stretch, and fluid flow-induced shear stress. How these signals influence LEC function and lymphatic vessel growth can be investigated by using different mechanotransduction assays in vitro and to some extent in vivo.In this chapter, we will focus on the mechanical forces that regulate lymphatic vessel expansion during embryonic development and possibly secondary lymphedema. In mouse embryos, it has been recently shown that the amount of interstitial fluid determines the extent of lymphatic vessel expansion via a mechanosensory complex formed by β1 integrin and vascular endothelial growth factor receptor-3 (VEGFR3). This model might as well apply to secondary lymphedema.

  15. 49 CFR 176.194 - Stowage of Class 1 (explosive) materials on magazine vessels.

    Science.gov (United States)

    2010-10-01

    ... magazine vessels. 176.194 Section 176.194 Transportation Other Regulations Relating to Transportation... REGULATIONS CARRIAGE BY VESSEL Detailed Requirements for Class 1 (Explosive) Materials Magazine Vessels § 176.194 Stowage of Class 1 (explosive) materials on magazine vessels. (a) General. The requirements of...

  16. Coordination and decision making of regulation, operation, and market activities in power systems

    Science.gov (United States)

    Nakashima, Tomoaki

    Electric power has been traditionally supplied to customers at regulated rates by vertically integrated utilities (VIUs), which own generation, transmission, and distribution systems. However, the regulatory authorities of VIUs are promoting competition in their businesses to lower the price of electric energy. Consequently, in new deregulated circumstances, many suppliers and marketers compete in the generation market, and conflict of interest may often occur over transmission. Therefore, a neutral entity, called an independent system operator (ISO), which operates the power system independently, has been established to give market participants nondiscriminatory access to transmission sectors with a natural monopoly, and to facilitate competition in generation sectors. Several types of ISOs are established at present, with their respective regions and authorities. The ISO receives many requests from market participants to transfer power, and must evaluate the feasibility of their requests under the system's condition. In the near future, regulatory authorities may impose various objectives on the ISOs. Then, based on the regulators' policies, the ISO must determine the optimal schedules from feasible solutions, or change the market participants' requests. In a newly developed power market, market participants will conduct their transactions in order to maximize their profit. The most crucial information in conducting power transactions is price and demand. A direct transaction between suppliers and consumers may become attractive because of its stability of price, while in a power exchange market, gaming and speculation of participants may push up electricity prices considerably. To assist the consumers in making effective decisions, suitable methods for forecasting volatile market price are necessary. This research has been approached from three viewpoints: Firstly, from the system operator's point of view, desirable system operation and power market structure

  17. Operation set for 2018 as regulator considers olkiluoto-3 licence application

    Energy Technology Data Exchange (ETDEWEB)

    Kraev, Kamen [NucNet, Brussels (Belgium)

    2017-02-15

    Finland has announced progress with its delayed nuclear project and has confirmed it will not be affected by anomalies discovered in some components manufactured for EPRs in France. The Olkiluoto-3 European Pressurised Reactor (EPR) nuclear plant under construction in Finland is on schedule to begin commercial operation in 2018 with the country's regulator preparing a safety assessment that will pave the way for fuel loading. Jouni Silvennoinen, senior vice-president for Olkiluoto-3 at Teollisuuden Voima Oyj (TVO), told NucNet that fuel loading at the EPR plant, which is nine years behind schedule, is expected in the spring of 2018. He said construction and licensing of the plant are progressing.

  18. Optimal Control and Operation Strategy for Wind Turbines Contributing to Grid Primary Frequency Regulation

    Directory of Open Access Journals (Sweden)

    Mun-Kyeom Kim

    2017-09-01

    Full Text Available This study introduces a frequency regulation strategy to enable the participation of wind turbines with permanent magnet synchronous generators (PMSGs. The optimal strategy focuses on developing the frequency support capability of PMSGs connected to the power system. Active power control is performed using maximum power point tracking (MPPT and de-loaded control to supply the required power reserve following a disturbance. A kinetic energy (KE reserve control is developed to enhance the frequency regulation capability of wind turbines. The coordination with the de-loaded control prevents instability in the PMSG wind system due to excessive KE discharge. A KE optimization method that maximizes the sum of the KE reserves at wind farms is also adopted to determine the de-loaded power reference for each PMSG wind turbine using the particle swarm optimization (PSO algorithm. To validate the effectiveness of the proposed optimal control and operation strategy, three different case studies are conducted using the PSCAD/EMTDC simulation tool. The results demonstrate that the optimal strategy enhances the frequency support contribution from PMSG wind turbines.

  19. Guam Abandoned Vessel Inventory

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Abandoned Vessel Project Data for Guam. Abandoned vessels pose a significant threat to the NOAA Trust resources through physical destruction of coral habitats...

  20. Florida Abandoned Vessel Inventory

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Abandoned Vessel Project Data for Florida. Abandoned vessels pose a significant threat to the NOAA Trust resources through physical destruction of coral...

  1. Vessel Arrival Info - Legacy

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Vessel Arrival Info is a spreadsheet that gets filled out during the initial stage of the debriefing process by the debriefer. It contains vessel name, trip...

  2. ALICE HMPID Radiator Vessel

    CERN Multimedia

    2003-01-01

    View of the radiator vessels of the ALICE/HMPID mounted on the support frame. Each HMPID module is equipped with 3 indipendent radiator vessels made out of neoceram and fused silica (quartz) windows glued together. The spacers inside the vessel are needed to stand the hydrostatic pressure. http://alice-hmpid.web.cern.ch/alice-hmpid

  3. 75 FR 39957 - Certificate of Alternative Compliance for the Offshore Supply Vessel/Well Stimulation Vessel BLUE...

    Science.gov (United States)

    2010-07-13

    ... Vessel BLUE TARPON AGENCY: Coast Guard, DHS. ACTION: Notice. SUMMARY: The Coast Guard announces that a Certificate of Alternative Compliance was issued for the offshore supply vessel BLUE TARPON as required by 33... Title 33, Code of Federal Regulation, Parts 81 and 89, has been issued for the offshore supply vessel...

  4. 75 FR 29358 - Maritime Security Directive 104-6 (Rev 2 and 3); Guidelines for U.S. Vessels Operating in High...

    Science.gov (United States)

    2010-05-25

    .... SUPPLEMENTARY INFORMATION: Somali pirates operate along a 2,300 mile coast and in 2.5 million square miles of... industry best management practices that have proven to be successful in thwarting pirate attacks and...

  5. 75 FR 24400 - Drawbridge Operation Regulation; CSX Railroad, Trout River, Mile 0.9, Jacksonville, FL

    Science.gov (United States)

    2010-05-05

    .... This rule will provide less restrictive vessel traffic flow as the bridge will be in the open position.... Protection of Children We have analyzed this rule under Executive Order 13045, Protection of Children from... River, Mile 0.9, Jacksonville, FL AGENCY: Coast Guard, DHS. ACTION: Final rule. SUMMARY: The Coast Guard...

  6. 78 FR 52694 - Drawbridge Operation Regulation; Trent River, New Bern, NC

    Science.gov (United States)

    2013-08-26

    ..., the bridge opens several times every day for recreational vessels transiting to and from the local... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND... . Type the docket number in the ``SEARCH'' box and click ``SEARCH.'' Click on Open Docket Folder on the...

  7. 75 FR 16007 - Drawbridge Operation Regulation; Lower Grand River, Iberville Parish, LA

    Science.gov (United States)

    2010-03-31

    ... rerouted, creating the need to have more time to transit the students over the bridges. Presently, 33 CFR... a congestion problem on the waterway during the closure periods and the additional 30 minutes would... of the time ] adjustment on vessel traffic and has concluded that there is not a significant impact...

  8. 76 FR 34848 - Drawbridge Operation Regulation; Atlantic Intracoastal Waterway (AIWW), Elizabeth River, Southern...

    Science.gov (United States)

    2011-06-15

    ... regulatory language. The suggestions offered are the following: 1. If any vessel is approaching the bridge... themselves with any necessary scheduling alterations for their planned trips; and (v) this change is meant to.... Protection of Children We have analyzed this rule under Executive Order 13045, Protection of Children from...

  9. 76 FR 79066 - Drawbridge Operation Regulation; Escatawpa River, Moss Point, MS

    Science.gov (United States)

    2011-12-21

    ... of the Mississippi Export Railroad Company swing bridge across the Escatawpa River, mile 3.0, at Moss.... SUPPLEMENTARY INFORMATION: The Mississippi Export Railroad Company has requested a temporary deviation from the... consists of commercial tugs with tows, fishing vessels, and other recreational crafts. There is only one...

  10. Purification of Mouse Brain Vessels.

    Science.gov (United States)

    Boulay, Anne-Cécile; Saubaméa, Bruno; Declèves, Xavier; Cohen-Salmon, Martine

    2015-11-10

    In the brain, most of the vascular system consists of a selective barrier, the blood-brain barrier (BBB) that regulates the exchange of molecules and immune cells between the brain and the blood. Moreover, the huge neuronal metabolic demand requires a moment-to-moment regulation of blood flow. Notably, abnormalities of these regulations are etiological hallmarks of most brain pathologies; including glioblastoma, stroke, edema, epilepsy, degenerative diseases (ex: Parkinson's disease, Alzheimer's disease), brain tumors, as well as inflammatory conditions such as multiple sclerosis, meningitis and sepsis-induced brain dysfunctions. Thus, understanding the signaling events modulating the cerebrovascular physiology is a major challenge. Much insight into the cellular and molecular properties of the various cell types that compose the cerebrovascular system can be gained from primary culture or cell sorting from freshly dissociated brain tissue. However, properties such as cell polarity, morphology and intercellular relationships are not maintained in such preparations. The protocol that we describe here is designed to purify brain vessel fragments, whilst maintaining structural integrity. We show that isolated vessels consist of endothelial cells sealed by tight junctions that are surrounded by a continuous basal lamina. Pericytes, smooth muscle cells as well as the perivascular astrocyte endfeet membranes remain attached to the endothelial layer. Finally, we describe how to perform immunostaining experiments on purified brain vessels.

  11. 50 CFR 300.130 - Vessel and gear restrictions.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Vessel and gear restrictions. 300.130... gear restrictions. (a) Factory vessels. Factory vessels are prohibited from operating in treaty waters... top of the trap that, when removed, will leave an opening no smaller than the throat or entrance of...

  12. Becoming a refinery leader by changing operations to match new product quality regulations

    Energy Technology Data Exchange (ETDEWEB)

    Mendez, Maryro P. [KBC Advanced Technologies, Surrey (United Kingdom)

    2012-07-01

    Global environmental concerns have forced the automotive and oil industries to increase efficiency and reduce emissions, which has led to the tightening of fuels specifications around the world. The implementation of ultra-low sulphur transport fuels has become a worldwide trend with growing momentum. Compliance with these standards requires the refiner to make decisions in advance of the implementation date. Therefore, in order to make changes on time, refiners are currently assessing options and changes required to comply with regulations by 2016. Similar regulations have been implemented in Europe already and KBC has the methodology and experience to assess the existing refinery configuration, unit capability and facility infrastructure to provide the basis for decision making. This paper focus on KBC's methodology which looks at the molecular management needed to produce the low levels of sulfur and toxic required in today's refined products. A key element to the study is the use of Petro-SIM for development of a representative detailed non-linear model, of the refinery which has been used to test ideas and configurations and help confirm the Refinery LP development activities. Using a Petro-SIM representation, KBC is able to make an assessment of the impact of imposing Tier 3 gasoline (sulphur to < 10 ppm) on the refinery, examining critical blending constraints, unused stream qualities and quantities and likely type and scale of capital investment that would be required while optimising unit operations and maximising margins. This paper illustrates KBC's current thinking based on studies done to date to review clean fuels and Tier 3 specifications options for specific refinery configurations. (author)

  13. Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator

    Science.gov (United States)

    Deng, Zengqin; Wang, Qing; Liu, Zhao; Zhang, Manfeng; Machado, Ana Carolina Dantas; Chiu, Tsu-Pei; Feng, Chong; Zhang, Qi; Yu, Lin; Qi, Lei; Zheng, Jiangge; Wang, Xu; Huo, Xinmei; Qi, Xiaoxuan; Li, Xiaorong; Wu, Wei; Rohs, Remo; Li, Ying; Chen, Zhongzhou

    2015-07-01

    Ferric uptake regulator (Fur) plays a key role in the iron homeostasis of prokaryotes, such as bacterial pathogens, but the molecular mechanisms and structural basis of Fur-DNA binding remain incompletely understood. Here, we report high-resolution structures of Magnetospirillum gryphiswaldense MSR-1 Fur in four different states: apo-Fur, holo-Fur, the Fur-feoAB1 operator complex and the Fur-Pseudomonas aeruginosa Fur box complex. Apo-Fur is a transition metal ion-independent dimer whose binding induces profound conformational changes and confers DNA-binding ability. Structural characterization, mutagenesis, biochemistry and in vivo data reveal that Fur recognizes DNA by using a combination of base readout through direct contacts in the major groove and shape readout through recognition of the minor-groove electrostatic potential by lysine. The resulting conformational plasticity enables Fur binding to diverse substrates. Our results provide insights into metal ion activation and substrate recognition by Fur that suggest pathways to engineer magnetotactic bacteria and antipathogenic drugs.

  14. Risk Assessment for Fishing Vessels at Fishing Grounds

    Directory of Open Access Journals (Sweden)

    Sergey Moyseenko

    2015-09-01

    Full Text Available Safety and efficiency of fishing fleet activity depend largely on the quality of management decisions. Cause-and-effect relationships of accidents involving fishing vessels were identified by means of an analysis of emergencies and fishing incidents. The suggested method of risks calculation is based on the use of statistical methods, fuzzy sets/expert estimations method and the probability theory. The following most common tasks are presented and solved: - there is an impact of two or more independent negative factors/events on the vessel such as failure of a sonar, a vessel operator error, another vessel operator error. - a transport vessel carries out loading and unloading of fishing vessels under different environmental conditions. The value of the risk of an emergency incident is determined. - the fishing vessel navigation performs under various meteorological conditions. A priori probability of incident-free operation is calculated according to expert estimations.

  15. Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels.

    Science.gov (United States)

    Al-Tamimi, Mohammad; Tan, Chee Wee; Qiao, Jianlin; Pennings, Gabrielle J; Javadzadegan, Ashkan; Yong, Andy S C; Arthur, Jane F; Davis, Amanda K; Jing, Jing; Mu, Fi-Tjen; Hamilton, Justin R; Jackson, Shaun P; Ludwig, Andreas; Berndt, Michael C; Ward, Christopher M; Kritharides, Leonard; Andrews, Robert K; Gardiner, Elizabeth E

    2012-05-03

    Ligand-induced ectodomain shedding of glycoprotein VI (GPVI) is a metalloproteinase-dependent event. We examined whether shear force, in the absence of GPVI ligand, was sufficient to induce shedding of GPVI. Human-citrated platelet-rich plasma or washed platelets were subjected to increasing shear rates in a cone-plate viscometer, and levels of intact and cleaved GPVI were examined by Western blot and ELISA. Pathophysiologic shear rates (3000-10 000 seconds(-1)) induced platelet aggregation and metalloproteinase-dependent appearance of soluble GPVI ectodomain, and GPVI platelet remnant. Shedding of GPVI continued after transient exposure to shear. Blockade of α(IIb)β(3), GPIbα, or intracellular signaling inhibited shear-induced platelet aggregation but minimally affected shear-induced shedding of GPVI. Shear-induced GPVI shedding also occurred in platelet-rich plasma or washed platelets isolated from a von Willebrand disease type 3 patient with no detectable VWF, implying that shear-induced activation of platelet metalloproteinases can occur in the absence of GPVI and GPIbα ligands. Significantly elevated levels of sGPVI were observed in 10 patients with stable angina pectoris, with well-defined single vessel coronary artery disease and mean intracoronary shear estimates at 2935 seconds(-1) (peak shear, 19 224 seconds(-1)). Loss of GPVI in platelets exposed to shear has potential implications for the stability of a forming thrombus at arterial shear rates.

  16. Interplay between Inflammatory Responses and Lymphatic Vessels.

    Science.gov (United States)

    Shin, Kihyuk; Lee, Seung-Hyo

    2014-08-01

    Lymphatic vessels are routes for leukocyte migration and fluid drainage. In addition to their passive roles in migration of leukocytes, increasing evidence indicates their active roles in immune regulation. Tissue inflammation rapidly induces lymphatic endothelial cell proliferation and chemokine production, thereby resulting in lymphangiogenesis. Furthermore, lymphatic endothelial cells induce T cell tolerance through various mechanisms. In this review, we focus on the current knowledge on how inflammatory cytokines affect lymphangiogenesis and the roles of lymphatic vessels in modulating immune responses.

  17. The effects of marine vessel fuel sulfur regulations on ambient PM2.5 at coastal and near coastal monitoring sites in the U.S.

    Science.gov (United States)

    Kotchenruther, Robert A.

    2017-02-01

    In August of 2012 the U.S. began implementing fuel sulfur limits on certain large commercial marine vessels within 200 nautical miles (nm) of its coasts as part of a North American Emissions Control Area (NA-ECA). The NA-ECA limited fuel sulfur use in these vessels to below 1% in 2012 and to below 0.1% starting in 2015. This work uses ambient PM2.5 monitoring data from the U.S. IMPROVE network and Positive Matrix Factorization (PMF) receptor modeling to assess the effectiveness of the NA-ECA at reducing ambient PM2.5 from high-sulfur residual fuel oil (RFO) use. RFO combustion emissions of PM2.5 are known to have a fairly unique vanadium (V) and nickel (Ni) trace metal signature. To determine if IMPROVE sites were affected by residual fuel oil combustion, V and Ni data from 65 IMPROVE sites in coastal States of the U.S. were analyzed from 2010 to 2011, the two years prior to NA-ECA implementation. 22 of these IMPROVE sites had a V and Ni correlation coefficient (r2) greater than 0.65 and were selected for further analysis by PMF. The slopes of the correlations between V and Ni at these 22 sites ranged from 2.2 to 4.1, consistent with reported V:Ni emission ratios from RFO combustion. Each of the 22 IMPROVE sites was modeled independently with PMF, using the available PM2.5 chemical speciation data from 2010 to 2015. PMF model solutions for the 22 sites contained from 5 to 9 factors, depending on the site. At every site a PMF factor was identified that was associated with RFO combustion, however, 9 sites had PMF factors where RFO combustion was mixed with other aerosol sources. For the remaining 13 sites, PM2.5 from RFO combustion was analyzed for three time periods; 2010-2011 representing the time period prior to the NA-ECA implementation (pre-NA-ECA), 2013-2014 representing the time period where fuel sulfur was limited to 1.0% (NA-ECA 1.0% S), and 2015 representing the time period where fuel sulfur was limited to 0.1% (NA-ECA 0.1% S). All 13 sites indicated

  18. Maury Journals - German Vessels

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — German vessels observations, after the 1853 Brussels Conference that set International Maritime Standards, modeled after Maury Marine Standard Observations.

  19. 76 FR 43226 - Drawbridge Operation Regulations; Bayou Liberty, Mile 2.0, St. Tammany Parish, Slidell, LA

    Science.gov (United States)

    2011-07-20

    ... SECURITY Coast Guard 33 CFR Part 117 RIN 1625-AA09 Drawbridge Operation Regulations; Bayou Liberty, Mile 2... (S433) bridge across Liberty Bayou, mile 2.0, at Slidell, St. Tammany Parish, Louisiana. The proposed... Development (LDOTD), the owner of the bridge, replaced the existing S433 pontoon bridge over Bayou Liberty...

  20. TV White spaces for wireless broadband in rural areas: the regulator, broadcaster and telecommunication(s) operator viewpoint

    CSIR Research Space (South Africa)

    Mfupe, LP

    2012-05-01

    Full Text Available from potential harmful interference of the secondary users through the use of regulator controlled spatial-temporal databases. Simultaneously, the delivery of low-cost service(s) to the end-user(s) could be achieved by the telecommunication operator...

  1. Protein expression patterns of cell cycle regulators in operable breast cancer.

    Science.gov (United States)

    Zagouri, Flora; Kotoula, Vassiliki; Kouvatseas, George; Sotiropoulou, Maria; Koletsa, Triantafyllia; Gavressea, Theofani; Valavanis, Christos; Trihia, Helen; Bobos, Mattheos; Lazaridis, Georgios; Koutras, Angelos; Pentheroudakis, George; Skarlos, Pantelis; Bafaloukos, Dimitrios; Arnogiannaki, Niki; Chrisafi, Sofia; Christodoulou, Christos; Papakostas, Pavlos; Aravantinos, Gerasimos; Kosmidis, Paris; Karanikiotis, Charisios; Zografos, George; Papadimitriou, Christos; Fountzilas, George

    2017-01-01

    To evaluate the prognostic role of elaborate molecular clusters encompassing cyclin D1, cyclin E1, p21, p27 and p53 in the context of various breast cancer subtypes. Cyclin E1, cyclin D1, p53, p21 and p27 were evaluated with immunohistochemistry in 1077 formalin-fixed paraffin-embedded tissues from breast cancer patients who had been treated within clinical trials. Jaccard distances were computed for the markers and the resulted matrix was used for conducting unsupervised hierarchical clustering, in order to identify distinct groups correlating with prognosis. Luminal B and triple-negative (TNBC) tumors presented with the highest and lowest levels of cyclin D1 expression, respectively. By contrast, TNBC frequently expressed Cyclin E1, whereas ER-positive tumors did not. Absence of Cyclin D1 predicted for worse OS, while absence of Cyclin E1 for poorer DFS. The expression patterns of all examined proteins yielded 3 distinct clusters; (1) Cyclin D1 and/or E1 positive with moderate p21 expression; (2) Cyclin D1 and/or E1, and p27 positive, p53 protein negative; and, (3) Cyclin D1 or E1 positive, p53 positive, p21 and p27 negative or moderately positive. The 5-year DFS rates for clusters 1, 2 and 3 were 70.0%, 79.1%, 67.4% and OS 88.4%, 90.4%, 78.9%, respectively. It seems that the expression of cell cycle regulators in the absence of p53 protein is associated with favorable prognosis in operable breast cancer.

  2. Sustainable Oceanographic Vessels - Setting an Example

    Science.gov (United States)

    van Leer, J. C.

    2009-12-01

    In response to climate change, global warming and post “peak oil” fuel scarcity, the oceanographic community should consider reducing its carbon foot print. Why should scientists operate inefficient vessels while lecturing the general public on the need to reduce CO2 emissions? We have already seen curtailment of ship schedules and ship lay-ups, due in part to rising fuel costs, following $140/barrel crude oil. When the global recession ends, upward pressure on oil prices will again commence. Who can forecast how high fuel prices may ultimately rise during the typical 25-30 year lifetime of a research vessel? Are we to curtail future work at sea when oceanic climate research is becoming ever more important? A catamaran research vessel has been designed which can be electrically propelled from by a combination of high efficiency generators, photovoltaic panels and/or sails. Sail produced power is transformed with propellers and motor/generators into electric power which is stored in battery banks. This vessel could operate as the first true hybrid oceanographic research vessel. It could even continue operations without fuel in cases of a severe fuel shortage or fueling denial. Since the power produced by any water turbine increases with the cube of the velocity flowing over its propeller, the low fluid friction and high stability of a catamaran, with reasonably slender hulls, provide an important boost to efficient hybrid operation. The author has chartered a 42’ hybrid catamaran sailboat and found it efficient and extremely easy to operate and control. A 79’ motor sailing catamaran research vessel by Lock Crowther Designs will be presented as one example of a sustainable research vessel with excellent speed and sea-keeping. A center well makes operation as a small drilling/coring ship for coastal climate investigation possible. The center well also supports a host of remote sensing and robotic gear handling capabilities.

  3. 33 CFR 155.205 - Discharge removal equipment for vessels 400 feet or greater in length.

    Science.gov (United States)

    2010-07-01

    ... vessels 400 feet or greater in length. 155.205 Section 155.205 Navigation and Navigable Waters COAST GUARD... REGULATIONS FOR VESSELS Vessel Equipment § 155.205 Discharge removal equipment for vessels 400 feet or greater in length. (a) Oil tankers and offshore oil barges with an overall length of 400 feet or more must...

  4. 33 CFR 155.210 - Discharge removal equipment for vessels less than 400 feet in length.

    Science.gov (United States)

    2010-07-01

    ... vessels less than 400 feet in length. 155.210 Section 155.210 Navigation and Navigable Waters COAST GUARD... REGULATIONS FOR VESSELS Vessel Equipment § 155.210 Discharge removal equipment for vessels less than 400 feet in length. (a) Oil tankers and offshore oil barges with an overall length of less than 400 feet must...

  5. PRESSURE-RESISTANT VESSEL

    NARCIS (Netherlands)

    Beukers, A.; De Jong, T.

    1997-01-01

    Abstract of WO 9717570 (A1) The invention is directed to a wheel-shaped pressure-resistant vessel for gaseous, liquid or liquefied material having a substantially rigid shape, said vessel comprising a substantially continuous shell of a fiber-reinforced resin having a central opening, an inner

  6. 76 FR 76637 - Drawbridge Operation Regulation; Saginaw River, Bay City, MI

    Science.gov (United States)

    2011-12-08

    ... and Purpose Lake Carriers Association (LCA), an organization representing U.S. shipping companies on... schedules and revised regulation were developed with all known stakeholders, including; LCA, Canadian...

  7. 76 FR 65118 - Drawbridge Operation Regulation; Bear Creek, Sparrows Point, MD

    Science.gov (United States)

    2011-10-20

    ... since the replacement of the bridge, approximately thirteen years ago. The regulations governing the..., approximately thirteen years ago. This Final Rule seeks to update the Code of Federal Regulations by removing... supply, distribution, or use of energy. The Administrator of the Office of Information and Regulatory...

  8. Model Of Navigational Safety Of Fishing Vessels In Polish EEZ

    Directory of Open Access Journals (Sweden)

    Przywarty Marcin

    2014-06-01

    Full Text Available The paper presents the assumptions of a simulation model for assessing the navigational safety of fishing vessels. The model consist of submodels of merchant and fishing vessels traffic, submodel of external condition and submodel of accident consequences. Paper present also a results of simulation experiment which was carried out for Polish EEZ. Model takes into account all Polish fishing vessels operating in the Polish EEZ with length more than 15 meters and the merchant vessels traffic in South Baltic Sea area. As a results positions of simulated collisions of fishing and merchant vessels, positions and sizes of simulated bunker spills and the positions of losses of fishing equipment were achieved.

  9. 77 FR 1407 - Regulated Navigation Area; Memorial Bridge Construction, Piscataqua River, Portsmouth, NH

    Science.gov (United States)

    2012-01-10

    ...The United States Coast Guard is establishing a regulated navigation area (RNA) on the navigable waters of the Piscataqua River under and surrounding the Memorial Bridge between Portsmouth, NH and Kittery, ME. This temporary interim rule is necessary to provide for the safety of life on the navigable waters during bridge demolition and replacement construction operations. This rule implements certain safety measures, including speed restrictions and the temporary suspension of vessel traffic during construction operations that could be hazardous to nearby vessels.

  10. 77 FR 22492 - Drawbridge Operation Regulations; Long Island, New York Inland Waterway from East Rockaway Inlet...

    Science.gov (United States)

    2012-04-16

    ..., shafts, couplings, bearings, lubrication lines, span lock motors, span lock reducers, span lock guides... standards are technical standards (e.g., specifications of materials, performance, design, or operation...

  11. 46 CFR 4.04-3 - Reports of lack of vessel communication.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Reports of lack of vessel communication. 4.04-3 Section... MARINE CASUALTIES AND INVESTIGATIONS Notice of Potential Vessel Casualty § 4.04-3 Reports of lack of vessel communication. The owner, charterer, managing operator or agent of a vessel that is required to...

  12. 33 CFR 104.280 - Security measures for delivery of vessel stores and bunkers.

    Science.gov (United States)

    2010-07-01

    ... vessel stores and bunkers. 104.280 Section 104.280 Navigation and Navigable Waters COAST GUARD... § 104.280 Security measures for delivery of vessel stores and bunkers. (a) General. The vessel owner or operator must ensure that security measures relating to the delivery of vessel stores and bunkers are...

  13. Regulation of store-operated Ca{sup 2+} entry activity by cell cycle dependent up-regulation of Orai2 in brain capillary endothelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Kito, Hiroaki [Department of Molecular & Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya (Japan); Department of Pharmacology, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto (Japan); Yamamura, Hisao; Suzuki, Yoshiaki; Yamamura, Hideto [Department of Molecular & Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya (Japan); Ohya, Susumu [Department of Molecular & Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya (Japan); Department of Pharmacology, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto (Japan); Asai, Kiyofumi [Department of Molecular Neurobiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya (Japan); Imaizumi, Yuji, E-mail: yimaizum@phar.nagoya-cu.ac.jp [Department of Molecular & Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya (Japan)

    2015-04-10

    Store-operated Ca{sup 2+} entry (SOCE) via Orai1 and STIM1 complex is supposed to have obligatory roles in the regulation of cellular functions of vascular endothelial cells, while little is known about the contribution of Orai2. Quantitative PCR and Western blot analyses indicated the expression of Orai2 and STIM2, in addition to Orai1 and STIM1 in bovine brain capillary endothelial cell line, t-BBEC117. During the exponential growth of t-BBEC117, the knockdown of Orai1 and STIM1 significantly reduced the SOCE activity, whereas Orai2 and STIM2 siRNAs had no effect. To examine whether endogenous SOCE activity contributes to the regulation of cell cycle progression, t-BBEC117 were synchronized using double thymidine blockage. At the G2/M phase, Ca{sup 2+} influx via SOCE was decreased and Orai2 expression was increased compared to the G0/G1 phase. When Orai2 was knocked down at the G2/M phase, the decrease in SOCE was removed, and cell proliferation was partly attenuated. Taken together, Orai1 significantly contributes to cell proliferation via the functional expression, which is presumably independent of the cell cycle phases. In construct, Orai2 is specifically up-regulated during the G2/M phase, negatively modulates the SOCE activity, and may contribute to the regulation of cell cycle progression in brain capillary endothelial cells. - Highlights: • Orai1 is essential for SOCE activity in brain capillary endothelial cells (BCECs). • Cell cycle independent expression of Orai1 regulated SOCE and cell proliferation. • Orai2 was up-regulated only at G2/M phase and this consequently reduced SOCE. • Orai2 as well as Orai1 is a key player controlling SOCE and proliferation in BCECs.

  14. The differential expression of Kiss1, MMP9 and angiogenic regulators across the feto-maternal interface of healthy human pregnancies: implications for trophoblast invasion and vessel development.

    Directory of Open Access Journals (Sweden)

    Mushi Matjila

    Full Text Available Genes involved in invasion of trophoblast cells and angiogenesis are crucial in determining pregnancy outcome. We therefore studied expression profiles of these genes in both fetal and maternal tissues to enhance our understanding of feto-maternal dialogue. We investigated the expression of genes involved in trophoblast invasion, namely Kiss1, Kiss1 Receptor (Kiss1R and MMP9 as well as the expression of angiogenic ligands Vascular Endothelial Growth Factor-A (VEGF-A and Prokineticin-1 (PROK1 and their respective receptors (VEGFR1, VEGFR2 and PROK1R across the feto-maternal interface of healthy human pregnancies. The placenta, placental bed and decidua parietalis were sampled at elective caesarean delivery. Real-time RT-PCR was used to investigate transcription, while immunohistochemistry and western blot analyses were utilized to study protein expression. We found that the expression of Kiss1 (p<0.001, Kiss1R (p<0.05 and MMP9 (p<0.01 were higher in the placenta compared to the placental bed and decidua parietalis. In contrast, the expression of VEGF-A was highest in the placental bed (p<0.001. While VEGFR1 expression was highest in the placenta (p<0.01, the expression of VEGFR2 was highest in the placental bed (p<0.001. Lastly, both PROK1 (p<0.001 and its receptor PROK1R (p<0.001 had highest expression in the placenta. Genes associated with trophoblast invasion were highly expressed in the placenta which could suggest that the influence on invasion capacity may largely be exercised at the fetal level. Furthermore, our findings on angiogenic gene expression profiles suggest that angiogenesis may be regulated by two distinct pathways with the PROK1/PROK1R system specifically mediating angiogenesis in the fetus and VEGFA/VEGFR2 ligand-receptor pair predominantly mediating maternal angiogenesis.

  15. 36 CFR 3.2 - Do other boating laws and regulations apply to me when I operate my boat on park waters?

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Do other boating laws and regulations apply to me when I operate my boat on park waters? 3.2 Section 3.2 Parks, Forests, and Public... boating laws and regulations apply to me when I operate my boat on park waters? (a) In addition to the...

  16. 2013 Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  17. 2011 Passenger Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  18. 2011 Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  19. 2013 Passenger Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  20. 2013 Tanker Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  1. 2013 Cargo Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  2. High Performance Marine Vessels

    CERN Document Server

    Yun, Liang

    2012-01-01

    High Performance Marine Vessels (HPMVs) range from the Fast Ferries to the latest high speed Navy Craft, including competition power boats and hydroplanes, hydrofoils, hovercraft, catamarans and other multi-hull craft. High Performance Marine Vessels covers the main concepts of HPMVs and discusses historical background, design features, services that have been successful and not so successful, and some sample data of the range of HPMVs to date. Included is a comparison of all HPMVs craft and the differences between them and descriptions of performance (hydrodynamics and aerodynamics). Readers will find a comprehensive overview of the design, development and building of HPMVs. In summary, this book: Focuses on technology at the aero-marine interface Covers the full range of high performance marine vessel concepts Explains the historical development of various HPMVs Discusses ferries, racing and pleasure craft, as well as utility and military missions High Performance Marine Vessels is an ideal book for student...

  3. Cheboygan Vessel Base

    Data.gov (United States)

    Federal Laboratory Consortium — Cheboygan Vessel Base (CVB), located in Cheboygan, Michigan, is a field station of the USGS Great Lakes Science Center (GLSC). CVB was established by congressional...

  4. Maury Journals - US Vessels

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — U.S. vessels observations, after the 1853 Brussels Conference that set International Maritime Standards, modeled after Maury Marine Standard Observations.

  5. 2011 Cargo Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  6. 2011 Tanker Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  7. 2013 Fishing Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  8. Coastal Logbook Survey (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains catch (landed catch) and effort for fishing trips made by vessels that have been issued a Federal permit for the Gulf of Mexico reef fish,...

  9. Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity.

    Science.gov (United States)

    Wang, Yixin; Jin, Yi; Mäe, Maarja Andaloussi; Zhang, Yang; Ortsäter, Henrik; Betsholtz, Christer; Mäkinen, Taija; Jakobsson, Lars

    2017-10-01

    Tissue fluid drains through blind-ended lymphatic capillaries, via smooth muscle cell (SMC)-covered collecting vessels into venous circulation. Both defective SMC recruitment to collecting vessels and ectopic recruitment to lymphatic capillaries are thought to contribute to vessel failure, leading to lymphedema. However, mechanisms controlling lymphatic SMC recruitment and its role in vessel maturation are unknown. Here, we demonstrate that platelet-derived growth factor B (PDGFB) regulates lymphatic SMC recruitment in multiple vascular beds. PDGFB is selectively expressed by lymphatic endothelial cells (LECs) of collecting vessels. LEC-specific deletion of Pdgfb prevented SMC recruitment causing dilation and failure of pulsatile contraction of collecting vessels. However, vessel remodelling and identity were unaffected. Unexpectedly, Pdgfb overexpression in LECs did not induce SMC recruitment to capillaries. This was explained by the demonstrated requirement of PDGFB extracellular matrix (ECM) retention for lymphatic SMC recruitment, and the low presence of PDGFB-binding ECM components around lymphatic capillaries. These results demonstrate the requirement of LEC-autonomous PDGFB expression and retention for SMC recruitment to lymphatic vessels, and suggest an ECM-controlled checkpoint that prevents SMC investment of capillaries, which is a common feature in lymphedematous skin. © 2017. Published by The Company of Biologists Ltd.

  10. Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity

    Science.gov (United States)

    Wang, Yixin; Jin, Yi; Mäe, Maarja Andaloussi; Zhang, Yang; Ortsäter, Henrik; Betsholtz, Christer; Mäkinen, Taija

    2017-01-01

    Tissue fluid drains through blind-ended lymphatic capillaries, via smooth muscle cell (SMC)-covered collecting vessels into venous circulation. Both defective SMC recruitment to collecting vessels and ectopic recruitment to lymphatic capillaries are thought to contribute to vessel failure, leading to lymphedema. However, mechanisms controlling lymphatic SMC recruitment and its role in vessel maturation are unknown. Here, we demonstrate that platelet-derived growth factor B (PDGFB) regulates lymphatic SMC recruitment in multiple vascular beds. PDGFB is selectively expressed by lymphatic endothelial cells (LECs) of collecting vessels. LEC-specific deletion of Pdgfb prevented SMC recruitment causing dilation and failure of pulsatile contraction of collecting vessels. However, vessel remodelling and identity were unaffected. Unexpectedly, Pdgfb overexpression in LECs did not induce SMC recruitment to capillaries. This was explained by the demonstrated requirement of PDGFB extracellular matrix (ECM) retention for lymphatic SMC recruitment, and the low presence of PDGFB-binding ECM components around lymphatic capillaries. These results demonstrate the requirement of LEC-autonomous PDGFB expression and retention for SMC recruitment to lymphatic vessels, and suggest an ECM-controlled checkpoint that prevents SMC investment of capillaries, which is a common feature in lymphedematous skin. PMID:28851707

  11. 75 FR 29693 - Drawbridge Operation Regulation; Oakland Inner Harbor Tidal Canal, Oakland/Alameda, CA, Schedule...

    Science.gov (United States)

    2010-05-27

    ... ``Document Type'' drop down menu select ``Proposed Rules'' and insert ``USCG-2009-0803'' in the ``Keyword... are technical standards (e.g., specifications of materials, performance, design, or operation; test...

  12. 75 FR 69906 - Drawbridge Operation Regulation; Atlantic Intracoastal Waterway (AIWW), Elizabeth River, Southern...

    Science.gov (United States)

    2010-11-16

    ... ``Document Type'' drop down menu select ``Proposed Rules'' and insert ``USCG-2010-0879'' in the ``Keyword... standards (e.g., specifications of materials, performance, design, or operation; test methods; sampling...

  13. 76 FR 40234 - Drawbridge Operation Regulations; Harlem River, New York City, NY

    Science.gov (United States)

    2011-07-08

    ... highlighted in blue. In the ``Document Type'' drop down menu select ``Proposed Rules'' and insert ``USCG-2011..., design, or operation; test methods; sampling procedures; and related management systems practices) that...

  14. Charging operation with high energy efficiency for electric vehicle valve-regulated lead-acid battery system

    Energy Technology Data Exchange (ETDEWEB)

    Ikeya, Tomohiko; Mita, Yuichi; Ishihara, Kaoru [Central Research Inst. of Electric Power Industry (CRIEPI), Komae Res. Lab., Lithium Battery Project, Tokyo (Japan); Sawada, Nobuyuki [Hokkaido Electric Power Co., Sapporo (Japan); Takagi, Sakae; Murakami, Jun-ichi [Tohoku Electric Power Co. Inc., Sendai (Japan); Kobayashi, Kazuyuki [Tokyo Electric Power Co., Yokohama (Japan); Sakabe, Tetsuya [Chubu Electric Power Co., Nagoya (Japan); Kousaka, Eiichi [Hokuriku Electric Power Co., Toyama (Japan); Yoshioka, Haruki [The Kansai Electric Power Co., Osaka (Japan); Kato, Satoru [The Chugoku Electric Power Co., Hiroshima (Japan); Yamashita, Masanori [Shikoku Research Inst. Inc., Takamatsu (Japan); Narisoko, Hayato [The Okinawa Electric Power Co., Naha (Japan); Nishiyama, Kazuo [The Central Electric Power Council, Tokyo (Japan); Adachi, Kazuyuki [Kyushu Electric Power Co., Fukuoka (Japan)

    2000-12-01

    A new, high-energy-efficiency charging operation with as little amount of overcharge as possible is proposed to improve the energy efficiency and the cycle life for an EV valve-regulated lead-acid battery. Under this operation, the EV battery system is charged with 105% of amount of the preceding discharge five out of six times and once with 115% in order that it is fully charged. The cycle lives were estimated using a valve-regulated lead-acid battery system of 12 modules connected in series, by SFUDS79 pattern discharging and measurement of the amount of discharge every 50 cycles. Three-step constant current charging with 115% of amount of the preceding discharge required more than 5 h with the final charging step of more than 210 min, with coulomb efficiency of only 87% and energy efficiency of 74%. On the other hand, under the high-energy-efficiency charging operation, three-step charging with 105% shortens the final charging time to 132 min. It was completed in less than 4 h with coulomb and energy efficiency of 95% and 84%, respectively. This operation increased the energy efficiency from 74% to 83% on average in six charging, and extended the cycle life by about 30% to more than 400 cycles. Decreasing the amount of charge by as much as possible suppressed the corrosion of the grids in the positive plate and the heat evolution in batteries due to shortening of the final charging step. Although the high-energy-efficiency charging operation led to the accumulation of inactive PbSO{sub 4} at the upper part of the negative plate, possibly due to the decreasing amount of overcharge, this operation could prolong the cycle life. Full charging once every six times is though to be effective in suppressing degradation caused by the accumulation of inactive PbSO{sub 4} in the negative plate due to the shortage of charge. (orig.)

  15. 76 FR 49975 - Inspection of Towing Vessels

    Science.gov (United States)

    2011-08-11

    ... related materials. All comments received will be posted, without change, to http://www.regulations.gov and... comments and material received during the comment period and may change this proposed rule based on your... consideration its size, organizational structure, and vessel types and services. Towing Safety Management System...

  16. 78 FR 59854 - Defense Federal Acquisition Regulation Supplement: Acquisitions in Support of Operations in...

    Science.gov (United States)

    2013-09-30

    ... writing to the address shown below on or before November 29, 2013, to be considered in the formation of a... formation of the final rule. List of Subjects in 48 CFR Parts 206, 212, 225, and 252 Government procurement. Manuel Quinones, Editor, Defense Acquisition Regulations System. Therefore, 48 CFR parts 206, 212, 225...

  17. 77 FR 21864 - Drawbridge Operation Regulation; Saginaw River, Bay City, MI

    Science.gov (United States)

    2012-04-12

    ..., MI AGENCY: Coast Guard, DHS. ACTION: Final rule. SUMMARY: The Coast Guard is revising the drawbridge... Bay City, MI. The previous regulation was confusing, outdated, and unnecessarily restrictive for both.... DATES: This rule is effective May 14, 2012. ADDRESSES: Comments and related materials received from the...

  18. 76 FR 3516 - Drawbridge Operation Regulations; Merrimack River, Newburyport and Salisbury, MA

    Science.gov (United States)

    2011-01-20

    ... Salisbury, MA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from regulations. SUMMARY: The... Salisbury, Massachusetts. The deviation is necessary to paint the bridge. This deviation allows the bridge... Newburyport US1 Bridge, across the Merrimack River at mile 3.4, between Newburyport and Salisbury...

  19. 26 CFR 1.172-8 - Net operating loss carryovers for regulated transportation corporations.

    Science.gov (United States)

    2010-04-01

    ... intrastate, suburban, municipal, or interurban electric railroad, (b) On an intrastate, municipal, or suburban trackless trolley system, (c) On a municipal or suburban bus system, or (d) By motor vehicle not... and are substantially as favorable to users and consumers as are the regulated rates, transportation...

  20. 78 FR 22423 - Drawbridge Operation Regulations; Taunton River, Fall River and Somerset, MA

    Science.gov (United States)

    2013-04-16

    ... http://www.regulations.gov . Type the docket number in the ``SEARCH'' box and click ``SEARCH.'' Click.... and 9 p.m. From 9 p.m. until 5 a.m. the draw opens on signal with at least one hour advance notice...

  1. Guidelines and Regulations for the Establishment and Operation of Missouri Extended Employment Sheltered Workshops.

    Science.gov (United States)

    Wyrick, Rex R.

    Determination of the need for workshops for handicapped people, development of a new corporation, the adoption of bylaws, financial considerations, federal laws, workshop staff, resource material, state law, regulations, and forms, and procedures for establishing an extended employment workshop are mentioned and expanded in appendixes. Appendixes…

  2. The passive biomechanics of human pelvic collecting lymphatic vessels.

    Science.gov (United States)

    Athanasiou, Dimitrios; Edgar, Lowell T; Jafarnejad, Mohammad; Nixon, Katherine; Duarte, Delfim; Hawkins, Edwin D; Jamalian, Samira; Cunnea, Paula; Lo Celso, Cristina; Kobayashi, Shunichi; Fotopoulou, Christina; Moore, James E

    2017-01-01

    The lymphatic system has a major significance in the metastatic pathways in women's cancers. Lymphatic pumping depends on both extrinsic and intrinsic mechanisms, and the mechanical behavior of lymphatic vessels regulates the function of the system. However, data on the mechanical properties and function of human lymphatics are lacking. Our aim is to characterize, for the first time, the passive biomechanical behavior of human collecting lymphatic vessels removed at pelvic lymph node dissection during primary debulking surgeries for epithelial ovarian cancer. Isolated vessels were cannulated and then pressurized at varying levels of applied axial stretch in a calcium-free Krebs buffer. Pressurized vessels were then imaged using multi-photon microscopy for collagen-elastin structural composition and fiber orientation. Both pressure-diameter and force-elongation responses were highly nonlinear, and axial stretching of the vessel served to decrease diameter at constant pressure. Pressure-diameter behavior for the human vessels is very similar to data from rat mesenteric vessels, though the human vessels were approximately 10× larger than those from rats. Multiphoton microscopy revealed the vessels to be composed of an inner layer of elastin with an outer layer of aligned collagen fibers. This is the first study that successfully described the passive biomechanical response and composition of human lymphatic vessels in patients with ovarian cancer. Future work should expand on this knowledge base with investigations of vessels from other anatomical locations, contractile behavior, and the implications on metastatic cell transport.

  3. 49 CFR 176.145 - Segregation in single hold vessels.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Segregation in single hold vessels. 176.145 Section 176.145 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS... VESSEL Detailed Requirements for Class 1 (Explosive) Materials Segregation § 176.145 Segregation in...

  4. Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation

    Science.gov (United States)

    Chauvier, Adrien; Picard-Jean, Frédéric; Berger-Dancause, Jean-Christophe; Bastet, Laurène; Naghdi, Mohammad Reza; Dubé, Audrey; Turcotte, Pierre; Perreault, Jonathan; Lafontaine, Daniel A.

    2017-01-01

    On the basis of nascent transcript sequencing, it has been postulated but never demonstrated that transcriptional pausing at translation start sites is important for gene regulation. Here we show that the Escherichia coli thiamin pyrophosphate (TPP) thiC riboswitch contains a regulatory pause site in the translation initiation region that acts as a checkpoint for thiC expression. By biochemically probing nascent transcription complexes halted at defined positions, we find a narrow transcriptional window for metabolite binding, in which the downstream boundary is delimited by the checkpoint. We show that transcription complexes at the regulatory pause site favour the formation of a riboswitch intramolecular lock that strongly prevents TPP binding. In contrast, cotranscriptional metabolite binding increases RNA polymerase pausing and induces Rho-dependent transcription termination at the checkpoint. Early transcriptional pausing may provide a general mechanism, whereby transient transcriptional windows directly coordinate the sensing of environmental cues and bacterial mRNA regulation. PMID:28071751

  5. 77 FR 421 - Drawbridge Operation Regulation; Long Island, New York Inland Waterway From East Rockaway Inlet...

    Science.gov (United States)

    2012-01-05

    ... shortest possible time frame. Without this rule the work would have to be suspended thereby delaying the... project necessary to allow the bridge to return to its full two span operation. The Coast Guard expects..., which guides the Coast Guard in complying with the National Environmental Policy Act of 1969 (NEPA) (42...

  6. 78 FR 1145 - Regulated Navigation Area; Housatonic River, Bridge Replacement Operations; Stratford, CT

    Science.gov (United States)

    2013-01-08

    .... Specifically, this includes the demolition of steel support beams. These large and extremely heavy steel... lowered on to a barge. This process will be extremely complex and presents many safety hazards including... 21, 2012, CT DOT outlined two phases of operations that require in-channel work, two steps of which...

  7. 76 FR 4818 - Drawbridge Operation Regulations; Hackensack River, Jersey City, NJ

    Science.gov (United States)

    2011-01-27

    ... of the Upper Hack Bridge across the Hackensack River, mile 6.9, at Secaucus, New Jersey. The..., Program Manager, Docket Operations, telephone 202-366-9826. SUPPLEMENTARY INFORMATION: The Upper Hack... necessary electrical system upgrades at the bridge. Under this temporary deviation the Upper Hack Bridge...

  8. 76 FR 50123 - Drawbridge Operation Regulations; Hackensack River, Jersey City, NJ

    Science.gov (United States)

    2011-08-12

    ... of the Hack Freight Bridge, mile 3.1, across the Hackensack River, at Jersey City, New Jersey. The... Operations, telephone 202-366-9826. SUPPLEMENTARY INFORMATION: The Hack Freight Bridge, across the Hackensack... bridge of equipment in order to provide openings. Under this temporary deviation the Hack Freight Bridge...

  9. 78 FR 67999 - Drawbridge Operation Regulation; Gulf Intracoastal Waterway, Treasure Island, FL

    Science.gov (United States)

    2013-11-13

    ... Waterway, Treasure Island, FL AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking. SUMMARY: The Coast Guard proposes to change the operating schedule that governs the Treasure Island Causeway Bridge, mile 119.0, Treasure Island, Florida. The Treasure Island Bridge is a double-leaf bascule bridge that...

  10. 76 FR 31279 - Regulatory Guidance: Applicability of the Federal Motor Carrier Safety Regulations to Operators...

    Science.gov (United States)

    2011-05-31

    ... interstate commerce. For example, in one of the scenarios, grain is transported from farms to an elevator in... guidance on the distinction between interstate and intrastate commerce in deciding whether operations of... three issues that could benefit from clarification. First, how does one distinguish between intra- and...

  11. 78 FR 31414 - Drawbridge Operation Regulation; China Basin, San Francisco, CA

    Science.gov (United States)

    2013-05-24

    ... in the ``SEARCH'' box and click ``SEARCH.'' Click on Open Docket Folder on the line associated with... Mean High Water in the closed-to-navigation position. The draw opens on signal if at least one hour.... The drawspan can be operated upon one hour advance notice for emergencies requiring the passage of...

  12. 78 FR 51664 - Vessel Traffic Service Updates, Including Establishment of Vessel Traffic Service Requirements...

    Science.gov (United States)

    2013-08-21

    ... pool gauge is at approximately 13.0 feet or above. Lower Mississippi River--0036699952: New Orleans... of Vessel Traffic Service Requirements for Port Arthur, Texas and Expansion of VTS Special Operating... for Port Arthur, Texas and Expansion of VTS Special Operating Area in Puget Sound'' (77 FR 55439). The...

  13. Liquid Nitrogen Subcooler Pressure Vessel Engineering Note

    Energy Technology Data Exchange (ETDEWEB)

    Rucinski, R.; /Fermilab

    1997-04-24

    The normal operating pressure of this dewar is expected to be less than 15 psig. This vessel is open to atmospheric pressure thru a non-isolatable vent line. The backpressure in the vent line was calculated to be less than 1.5 psig at maximum anticipated flow rates.

  14. 78 FR 63235 - Tank Vessel Oil Transfers

    Science.gov (United States)

    2013-10-23

    ... engaged in oil transfer operations? 12. Are there conflicts or areas of improvement with regard to... SECURITY Coast Guard Tank Vessel Oil Transfers AGENCY: Coast Guard, DHS. ACTION: Notice and request for comments. SUMMARY: The Coast Guard announces that it is considering new measures to reduce the risks of oil...

  15. Improved nuclear power plant operations and safety through performance-based safety regulation.

    Science.gov (United States)

    Golay, M W

    2000-01-07

    This paper illustrates some of the promise and needed future work for risk-informed, performance-based regulation (RIPBR). RIPBR is an evolving alternative to the current prescriptive method of nuclear safety regulation. Prescriptive regulation effectively constitutes a long, fragmented checklist of requirements that safety-related systems in a plant must satisfy. RIPBR, instead, concentrates upon satisfying negotiated performance goals and incentives for judging and rewarding licensee behavior to improve safety and reduce costs. In a project reported here, a case study was conducted concerning a pressurized water reactor (PWR) emergency diesel generator (EDG). Overall, this work has shown that the methods of RIPBR are feasible to use, and capable of justifying simultaneous safety and economic nuclear power improvements. However, it also reveals several areas where the framework of RIPBR should be strengthened. First, researchers need better data and understanding regarding individual component-failure modes that may cause components to fail. Not only are more data needed on failure rates, but more data and understanding are needed to enable analysts to evaluate whether these failures become more likely as the interval between tests is increased. This is because the current state of failure data is not sufficiently finely detailed to define the failure rates of individual component failure modes; such knowledge is needed when changing component-specific regulatory requirements. Second, the role of component testing, given that a component has failed, needs to be strengthened within the context of RIPBR. This includes formulating requirements for updating the prior probability distribution of a component failure rate and conducting additional or more frequent testing. Finally, as a means of compensating for unavoidable uncertainty as an obstacle to regulatory decision-making, limits to knowledge must be treated explicitly and formally. This treatment includes the

  16. 33 CFR 150.355 - How are other vessels cleared to move within the safety zone?

    Science.gov (United States)

    2010-07-01

    ... landing (STL) system, paragraphs (a) and (b) of this section apply once a tanker connects to the STL buoy. ... deepwater port's person in charge of vessel operations is required before a vessel, other than a tanker or...

  17. Fluorescent nanoparticle beacon for logic gate operation regulated by strand displacement.

    Science.gov (United States)

    Yang, Jing; Shen, Lingjing; Ma, Jingjing; Schlaberg, H Inaki; Liu, Shi; Xu, Jin; Zhang, Cheng

    2013-06-26

    A mechanism is developed to construct a logic system by employing DNA/gold nanoparticle (AuNP) conjugates as a basic work unit, utilizing a fluorescent beacon probe to detect output signals. To implement the logic circuit, a self-assembly DNA structure is attached onto nanoparticles to form the fluorescent beacon. Moreover, assisted by regulation of multilevel strand displacement, cascaded logic gates are achieved. The computing results are detected by methods using fluorescent signals, gel electrophoresis and transmission electron microscope (TEM). This work is expected to demonstrate the feasibility of the cascaded logic system based on fluorescent nanoparticle beacons, suggesting applications in DNA computation and biotechnology.

  18. Methodology for the Regulation of Boom Sprayers Operating in Circular Trajectories

    Directory of Open Access Journals (Sweden)

    Alfredo Serreta

    2011-04-01

    Full Text Available A methodology for the regulation of boom sprayers working in circular trajectories has been developed. In this type of trajectory, the areas of the plots of land treated by the outer nozzles of the boom are treated at reduced rates, and those treated by the inner nozzles are treated in excess. The goal of this study was to establish the methodology to determine the flow of the individual nozzles on the boom to guarantee that the dose of the product applied per surface unit is similar across the plot. This flow is a function of the position of the equipment (circular trajectory radius and of the displacement velocity such that the treatment applied per surface unit is uniform. GPS technology was proposed as a basis to establish the position and displacement velocity of the tractor. The viability of this methodology was simulated considering two circular plots with radii of 160 m and 310 m, using three sets of equipment with boom widths of 14.5, 24.5 and 29.5 m. Data showed as increasing boom widths produce bigger errors in the surface dose applied (L/m2. Error also increases with decreasing plot surface. As an example, considering the three boom widths of 14.5, 24.5 and 29.5 m working on a circular plot with a radius of 160 m, the percentage of surface with errors in the applied surface dose greater than 5% was 30%, 58% and 65% respectively. Considering a circular plot with radius of 310 m the same errors were 8%, 22% and 31%. To obtain a uniform superficial dose two sprayer regulation alternatives have been simulated considering a 14.5 m boom: the regulation of the pressure of each nozzle and the regulation of the pressure of each boom section. The viability of implementing the proposed methodology on commercial boom sprayers using GPS antennas to establish the position and displacement velocity of the tractor was justified with a field trial in which a self-guiding commercial GPS system was used along with three precision GPS systems located in

  19. The influence of chemistry concentration on the fracture risk of a reactor pressure vessel subjected to pressurized thermal shocks

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Pin-Chiun [Institute of Nuclear Engineering and Science, National Tsing-Hua University, Hsinchu 30013, Taiwan, ROC (China); Chou, Hsoung-Wei, E-mail: hwchou@iner.gov.tw [Institute of Nuclear Energy Research, Taoyuan 32546, Taiwan, ROC (China); Ferng, Yuh-Ming [Institute of Nuclear Engineering and Science, National Tsing-Hua University, Hsinchu 30013, Taiwan, ROC (China)

    2016-02-15

    Highlights: • Probabilistic fracture mechanics method was used to analyze a reactor pressure vessel. • Effects of copper and nickel contents on RPV fracture probability under PTS were investigated and discussed. • Representative PTS transients of Beaver Valley nuclear power plant were utilized. • The range of copper and nickel contents of the RPV materials were suggested. • With different embrittlement levels the dominated PTS category is different. - Abstract: The radiation embrittlement behavior of reactor pressure vessel shell is influenced by the chemistry concentration of metal materials. This paper aims to study the effects of copper and nickel content variations on the fracture risk of pressurized water reactor (PWR) pressure vessel subjected to pressurized thermal shock (PTS) transients. The probabilistic fracture mechanics (PFM) code, FAVOR, which was developed by the Oak Ridge National Laboratory in the United States, is employed to perform the analyses. A Taiwan domestic PWR pressure vessel assumed with varied copper and nickel contents of beltline region welds and plates is investigated in the study. Some PTS transients analyzed from Beaver Valley Unit 1 for establishing the U.S. NRC's new PTS rule are applied as the loading condition. It is found that the content variation of copper and nickel will significantly affect the radiation embrittlement and the fracture probability of PWR pressure vessels. The results can be regarded as the risk incremental factors for comparison with the safety regulation requirements on vessel degradation as well as a reference for the operation of PWR plants in Taiwan.

  20. Progress of ITER vacuum vessel

    Energy Technology Data Exchange (ETDEWEB)

    Ioki, K., E-mail: Kimihiro.Ioki@iter.org [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Bayon, A. [F4E, c/ Josep Pla, No. 2, Torres Diagonal Litoral, Edificio B3, E-08019 Barcelona (Spain); Choi, C.H.; Daly, E.; Dani, S.; Davis, J.; Giraud, B.; Gribov, Y.; Hamlyn-Harris, C.; Jun, C.; Levesy, B. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Kim, B.C. [NFRI, 52 Yeoeundong Yuseonggu, Daejeon 305-333 (Korea, Republic of); Kuzmin, E. [NTC “Sintez”, Efremov Inst., 189631 Metallostroy, St. Petersburg (Russian Federation); Le Barbier, R.; Martinez, J.-M. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Pathak, H. [ITER-India, A-29, GIDC Electronic Estate, Sector 25, Gandhinagar 382025 (India); Preble, J. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Sa, J.W. [NFRI, 52 Yeoeundong Yuseonggu, Daejeon 305-333 (Korea, Republic of); Terasawa, A.; Utin, Yu. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); and others

    2013-10-15

    Highlights: ► This covers the overall status and progress of the ITER vacuum vessel activities. ► It includes design, R and D, manufacturing and approval process of the regulators. ► The baseline design was completed and now manufacturing designs are on-going. ► R and D includes ISI, dynamic test of keys and lip-seal welding/cutting technology. ► The VV suppliers produced full-scale mock-ups and started VV manufacturing. -- Abstract: Design modifications were implemented in the vacuum vessel (VV) baseline design in 2011–2012 for finalization. The modifications are mostly due to interface components, such as support rails and feedthroughs for the in-vessel coils (IVC). Manufacturing designs are being developed at the domestic agencies (DAs) based on the baseline design. The VV support design was also finalized and tests on scale mock-ups are under preparation. Design of the in-wall shielding (IWS) has progressed, considering the assembly methods and the required tolerances. Further modifications are required to be consistent with the DAs’ manufacturing designs. Dynamic tests on the inter-modular and stub keys to support the blanket modules are being performed to measure the dynamic amplification factor (DAF). An in-service inspection (ISI) plan has been developed and R and D was launched for ISI. Conceptual design of the VV instrumentation has been developed. The VV baseline design was approved by the agreed notified body (ANB) in accordance with the French Nuclear Pressure Equipment Order procedure.

  1. Regulators of alternative polyadenylation operate at the transition from mitosis to meiosis.

    Science.gov (United States)

    Shan, Lingjuan; Wu, Chan; Chen, Di; Hou, Lei; Li, Xin; Wang, Lixia; Chu, Xiao; Hou, Yifeng; Wang, Zhaohui

    2017-02-20

    In the sexually reproductive organisms, gametes are produced by meiosis following a limited mitotic amplification. However, the intrinsic program switching cells from mitotic to meiotic cycle is unclear. Alternative polyadenylation (APA) is a highly conserved means of gene regulation and is achieved by the RNA 3'-processing machinery to generate diverse 3'UTR profiles. In Drosophila spermatogenesis, we observed distinct profiles of transcriptome-wide 3'UTR between mitotic and meiotic cells. In mutant germ cells stuck in mitosis, 3'UTRs of hundreds of genes were consistently shifted. Remarkably, altering the levels of multiple 3'-processing factors disrupted germline's progression to meiosis, indicative of APA's active role in this transition. An RNA-binding protein (RBP) Tut could directly bind 3'UTRs of 3'-processing factors whose expressions were repressed in the presence of Tut-containing complex. Further, we demonstrated that this RBP complex could execute the repression post-transcriptionally by recruiting CCR4/Twin of deadenylation complex. Thus, we propose that an RBP complex regulates the dynamic APA profile to promote the mitosis-to-meiosis transition. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  2. 75 FR 66309 - Vessel Traffic Service Lower Mississippi River

    Science.gov (United States)

    2010-10-28

    ... consisting of measures for controlling or supervising vessel traffic to protect the marine environment. 33 U... working group. The Coast Guard encourages stakeholders to provide feedback on VTS operations by contacting... supervising vessel traffic to protect the marine environment. In enacting PWSA in 1972, Congress found that...

  3. 33 CFR 104.305 - Vessel Security Assessment (VSA) requirements.

    Science.gov (United States)

    2010-07-01

    ... baggage; and (vi) Vessel stores; (2) Threat assessments, including the purpose and methodology of the... availability of security communications, information, and equipment. (c) Analysis and recommendations. In... may, if damaged or used illicitly, pose a risk to people, property, or operations on board the vessel...

  4. 40 CFR 63.646 - Storage vessel provisions.

    Science.gov (United States)

    2010-07-01

    ...) National Emission Standards for Hazardous Air Pollutants From Petroleum Refineries § 63.646 Storage vessel... operator may use good engineering judgment or test results to determine the stored liquid weight percent... 63.120(b)(10)(iii) for all or some storage vessels at petroleum refineries subject to this subpart...

  5. Keeping control when cutting through a reactor vessel

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1997-09-01

    UK Robotics` Advanced Teleoperation Controller (ATC) is a key component of one of the most extensive remote handling operations currently being undertaken - the removal of 165 mm diameter, 90 mm thick samples of carbon-manganese steel from the base of the Trawsfyndd reactor pressure vessel. These will then be used to assess the material properties of the vessel welds. (author).

  6. GOLD PRESSURE VESSEL SEAL

    Science.gov (United States)

    Smith, A.E.

    1963-11-26

    An improved seal between the piston and die member of a piston-cylinder type pressure vessel is presented. A layer of gold, of sufficient thickness to provide an interference fit between the piston and die member, is plated on the contacting surface of at least one of the members. (AEC)

  7. Network of endocardial vessels.

    Science.gov (United States)

    Lee, Byung-Cheon; Kim, Hong Bae; Sung, Baeckkyoung; Kim, Ki Woo; Sohn, Jamin; Son, Boram; Chang, Byung-Joon; Soh, Kwang-Sup

    2011-01-01

    Although there have been reports on threadlike structures inside the heart, they have received little attention. We aimed to develop a method for observing such structures and to reveal their ultrastructures. An in situ staining method, which uses a series of procedures of 0.2-0.4% trypan blue spraying and washing, was applied to observe threadlike structures on the surfaces of endocardia. The threadlike structures were isolated and observed by using confocal laser scanning microscopy (CLSM) and transmission electron microscopy (TEM). Networks of endocardial vessels (20 μm in thickness) with expansions (40-100 μm in diameter) were visualized; they were movable on the endocardium of the bovine atrium and ventricle. CLSM showed that (1) rod-shaped nuclei were aligned along the longitudinal direction of the endocardial vessel and (2) there were many cells inside the expansion. TEM on the endocardial vessel revealed that (1) there existed multiple lumens (1-7 μm in diameter) and (2) the extracellular matrices mostly consisted of collagen fibers, which were aligned along the longitudinal direction of the endocardial vessel or were locally organized in reticular structures. We investigated the endocardial circulatory system in bovine cardiac chambers and its ultrastructures, such as nucleic distributions, microlumens, and collagenous extracellular matrices. Copyright © 2011 S. Karger AG, Basel.

  8. Pressurized Vessel Slurry Pumping

    Energy Technology Data Exchange (ETDEWEB)

    Pound, C.R.

    2001-09-17

    This report summarizes testing of an alternate ''pressurized vessel slurry pumping'' apparatus. The principle is similar to rural domestic water systems and ''acid eggs'' used in chemical laboratories in that material is extruded by displacement with compressed air.

  9. AUTOMATIC REGULATOR FOR NON-STATIONARY OBJECTS WITH AN INCREASED RANGE OF NORMAL OPERATION

    Directory of Open Access Journals (Sweden)

    A. I. Pavlov

    2017-06-01

    Full Text Available Many objects automatic control unsteady. This is manifested in the change of their parameters. Therefore, periodically adjust the required parameters of the controller. This work is usually carried out rarely. For a long time, regulators are working with is not the optimal settings. The consequence of this is the low quality of many industrial control systems. The solution problem is the use of robust controllers. Explores the possibility of increasing the survivability of automatic control systems by expanding the area of their normal work. This is achieved by using an artificial neural network simple structure. The method is based on the cooperative effect of neural structures. In this block diagram of the controller is very simple. Such control effectively compensates the coordinate perturbations if they act on the control channel.

  10. Microplastics in the context of regulation of commercial shellfish aquaculture operations.

    Science.gov (United States)

    Schoof, Rosalind A; DeNike, Jesse

    2017-05-01

    Shellfish aquaculture in the Salish Sea (encompassing the Strait of Juan de Fuca, Puget Sound, and the Georgia Strait) is a major source of clams, oysters, and mussels in the United States and Canada. Plastic gear is necessary for the viability of many of these operations. During the past few years, shellfish farm permits issued in Washington State have been challenged on various bases that have included allegations that the plastic gear is releasing microplastics, commonly defined as particles less than 5 mm in diameter. Published survey data on sources of marine plastic debris demonstrate the very limited contribution of aquaculture gear. Both permits and industry codes of practice provide procedures to minimize loss of gear to the marine environment. Plastic gear is also designed specifically to maintain its integrity and not degrade in the marine environment. Plastic degradation is greatest on beaches with high UV exposure, whereas aquaculture gear is mostly underwater and/or covered by biofoulants. Available data for microplastics in water, sediment, and biota of the Salish Sea do not suggest significant release of microplastics from shellfish aquaculture operations. Integr Environ Assess Manag 2017;13:522-527. © 2017 SETAC. © 2017 SETAC.

  11. UST System Compatibility with Petroleum-Biofuel Blends: A Brief Guide to the 2015 Federal UST Regulations for Owners and Operators of USTs Located on Tribal Lands

    Science.gov (United States)

    Review information for UST owners and operators on tribal lands with compatibility requirements in the 2015 federal UST regulation when storing gasoline blends containing greater than 10 percent ethanol or diesel blends containing greater than 20 percent.

  12. Regulating Future Offshore Grids: Economic Impact Analysis on Wind Parks and Transmission System Operators

    DEFF Research Database (Denmark)

    Kitzing, Lena; Schröder, Sascha Thorsten

    The increasing development of offshore wind parks in the European offshore territory may lead to meshed offshore grids in which each wind park might be connected to several countries. Such offshore grids could be subject to various regulatory regimes, depending on the degree of cooperation between...... the respective countries. This study focuses on how investors in wind parks and transmission systems are affected by the choice of regulatory regime in offshore grids with one to four countries connected. In order to capture the uncertainties related to the exposure to market prices as well as risks related...... to line failures, we develop a stochastic model for an exemplary wind park and offshore grid. This yields the real option values of operational flexibility from additional connections. Simulation results show that the choice of regulatory regime, including market access and pricing rules, can have...

  13. Toward an operational model of decision making, emotional regulation, and mental health impact.

    Science.gov (United States)

    Collura, Thomas Francis; Zalaquett, Ronald P; Bonnstetter, Carlos Joyce; Chatters, Seria J

    2014-01-01

    Current brain research increasingly reveals the underlying mechanisms and processes of human behavior, cognition, and emotion. In addition to being of interest to a wide range of scientists, educators, and professionals, as well as laypeople, brain-based models are of particular value in a clinical setting. Psychiatrists, psychologists, counselors, and other mental health professionals are in need of operational models that integrate recent findings in the physical, cognitive, and emotional domains, and offer a common language for interdisciplinary understanding and communication. Based on individual traits, predispositions, and responses to stimuli, we can begin to identify emotional and behavioral pathways and mental processing patterns. The purpose of this article is to present a brain-path activation model to understand individual differences in decision making and psychopathology. The first section discusses the role of frontal lobe electroencephalography (EEG) asymmetry, summarizes state- and trait-based models of decision making, and provides a more complex analysis that supplements the traditional simple left-right brain model. Key components of the new model are the introduction of right hemisphere parallel and left hemisphere serial scanning in rendering decisions, and the proposition of pathways that incorporate both past experiences as well as future implications into the decision process. Main attributes of each decision-making mechanism are provided. The second section applies the model within the realm of clinical mental health as a tool to understand specific human behavior and pathology. Applications include general and chronic anxiety, depression, paranoia, risk taking, and the pathways employed when well-functioning operational integration is observed. Finally, specific applications such as meditation and mindfulness are offered to facilitate positive functioning.

  14. Regulation of nif expression in Methanococcus maripaludis: roles of the euryarchaeal repressor NrpR, 2-oxoglutarate, and two operators.

    Science.gov (United States)

    Lie, Thomas J; Wood, Gwendolyn E; Leigh, John A

    2005-02-18

    The methanogenic archaean Methanococcus maripaludis can use ammonia, alanine, or dinitrogen as a nitrogen source for growth. The euryarchaeal nitrogen repressor NrpR controls the expression of the nif (nitrogen fixation) operon, resulting in full repression with ammonia, intermediate repression with alanine, and derepression with dinitrogen. NrpR binds to two tandem operators in the nif promoter region, nifOR(1) and nifOR(2). Here we have undertaken both in vivo and in vitro approaches to study the way in which NrpR, nifOR(1), nifOR(2), and the effector 2-oxoglutarate (2OG) combine to regulate nif expression, leading to a comprehensive understanding of this archaeal regulatory system. We show that NrpR binds as a dimer to nifOR(1) and cooperatively as two dimers to both operators. Cooperative binding occurs only with both operators present. nifOR(1) has stronger binding and by itself can mediate the repression of nif transcription during growth on ammonia, unlike the weakly binding nifOR(2). However, nifOR(2) in combination with nifOR(1) is critical for intermediate repression during growth on alanine. Accordingly, NrpR binds to both operators together with higher affinity than to nifOR(1) alone. NrpR responds directly to 2OG, which weakens its binding to the operators. Hence, 2OG is an intracellular indicator of nitrogen deficiency and acts as an inducer of nif transcription via NrpR. This model is upheld by the recent finding (J. A. Dodsworth and J. A. Leigh, submitted for publication) in our laboratory that 2OG levels in M. maripaludis vary with growth on different nitrogen sources.

  15. Distribution of the In-Vessel Diagnostics in ITER Tokamak

    Energy Technology Data Exchange (ETDEWEB)

    González, Jorge, E-mail: Jorge.Gonzalez@iter.org [Rüecker Lypsa, Carretera del Prat, 65, Cornellá de Llobregat (Spain); Clough, Matthew; Martin, Alex; Woods, Nick; Suarez, Alejandro [ITER Organization, Route de Vinon sur Verdon-CS 90 046 13067 Saint Paul Lez Durance (France); Martinez, Gonzalo [Technical University Of Catalonia (UPC), Barcelona-Tech, Barcelona (Spain); Stefan, Gicquel; Yunxing, Ma [ITER Organization, Route de Vinon sur Verdon-CS 90 046 13067 Saint Paul Lez Durance (France)

    2017-01-15

    The ITER In-Vessel Diagnostics have been distributed around the In-Vessel shell to understand burning plasma physics and assist in machine operation. Each diagnostics component has its own requirements, constraints, and even exclusion among them for the highly complex In-Vessel environment. The size of the plasma, the requirement to be able to align the blanket system to the magnetic centre of the machine, the cooling requirements of the blanket system and the size of the pressure vessel itself all add to the difficulties of integrating these systems into the remaining space available. The available space for the cables inside the special trays (in-Vessel looms) is another constraint to allocate In-Vessel electrical sensors. Besides this, there are issues with the Assembly sequences and surface & volumetric neutron heating considerations that have imposed several additional restrictions.

  16. Optimal Operation of Distribution Electronic Power Transformer Using Linear Quadratic Regulator Method

    Directory of Open Access Journals (Sweden)

    Mohammad Hosein Rezaei

    2011-10-01

    Full Text Available Transformers perform many functions such as voltage transformation, isolation and noise decoupling. They are indispensable components in electric power distribution system. However, at low frequencies (50 Hz, they are one of the heaviest and the most expensive equipment in an electrical distribution system. Nowadays, electronic power transformers are used instead of conventional power transformers that do voltage transformation and power delivery in power system by power electronic converter. In this paper, the structure of distribution electronic power transformer (DEPT are analized and then paid attention on the design of a linear-quadratic-regulator (LQR with integral action to improve dynamic performance of DEPT with voltage unbalance, voltage sags, voltage harmonics and voltage flicker. The presentation control strategy is simulated by MATLAB/SIMULINK. In addition, the results that are in terms of dc-link reference voltage, input and output voltages clearly show that a better dynamic performance can be achieved by using the LQR method when compared to other techniques.

  17. Vessel discoloration detection in malarial retinopathy

    Science.gov (United States)

    Agurto, C.; Nemeth, S.; Barriga, S.; Soliz, P.; MacCormick, I.; Taylor, T.; Harding, S.; Lewallen, S.; Joshi, V.

    2016-03-01

    Cerebral malaria (CM) is a life-threatening clinical syndrome associated with malarial infection. It affects approximately 200 million people, mostly sub-Saharan African children under five years of age. Malarial retinopathy (MR) is a condition in which lesions such as whitening and vessel discoloration that are highly specific to CM appear in the retina. Other unrelated diseases can present with symptoms similar to CM, therefore the exact nature of the clinical symptoms must be ascertained in order to avoid misdiagnosis, which can lead to inappropriate treatment and, potentially, death. In this paper we outline the first system to detect the presence of discolored vessels associated with MR as a means to improve the CM diagnosis. We modified and improved our previous vessel segmentation algorithm by incorporating the `a' channel of the CIELab color space and noise reduction. We then divided the segmented vasculature into vessel segments and extracted features at the wall and in the centerline of the segment. Finally, we used a regression classifier to sort the segments into discolored and not-discolored vessel classes. By counting the abnormal vessel segments in each image, we were able to divide the analyzed images into two groups: normal and presence of vessel discoloration due to MR. We achieved an accuracy of 85% with sensitivity of 94% and specificity of 67%. In clinical practice, this algorithm would be combined with other MR retinal pathology detection algorithms. Therefore, a high specificity can be achieved. By choosing a different operating point in the ROC curve, our system achieved sensitivity of 67% with specificity of 100%.

  18. Planning, Designing, Operating, and Regulating a Geologic Sequestration Repository as an Underground Landfill-A Review.

    Science.gov (United States)

    Brown, Christopher J; Poiencot, Brandon; Sornberger, Charles

    2011-12-01

    Geologic sequestration appears to be a technically feasible method of storing carbon dioxide in underground aquifers in order to lower greenhouse gas emissions into the atmosphere. The overall feasibility of geologic sequestration is still in question and as such, has been the focus of intense research over the past decade. Researchers have looked to the oil/gas industry and water well industry for lessons learned and technical knowledge, however, a better industry to emulate may well be the waste industry. Viewing geologic sequestration repositories as underground landfills has a great many benefits. First, there is a plethora of existing research and investigations that are directly analogous to geologic sequestration projects. Second, the regulatory framework is rather mature and can be easily adapted to serve geologic sequestration. This paper conducts an extensive literature search of the environmental, waste, and geologic sequestration literature to ascertain planning, design, and operational methodologies, lessons learned, and concepts that are directly useful for geologic sequestration to improve the technical and regulatory framework. Lastly, the paper uses a hypothetical underground landfill geologic sequestration site (ULGSS) in Florida, USA to discuss some of the findings and implications from the literature. It is concluded that there are a number of literature findings from the waste and environmental arena that should be adapted for geologic sequestration. [Box: see text].

  19. Planning, designing, operating, and regulating a geologic sequestration repository as an underground landfill--a review.

    Science.gov (United States)

    Brown, Christopher J; Poiencot, Brandon; Sornberger, Charles

    2011-12-01

    Geologic sequestration appears to be a technically feasible method of storing carbon dioxide in underground aquifers in order to lower greenhouse gas emissions into the atmosphere. The overall feasibility of geologic sequestration is still in question and as such, has been the focus of intense research over the past decade. Researchers have looked to the oil/gas industry and water well industry for lessons learned and technical knowledge, however, a better industry to emulate may well be the waste industry. Viewing geologic sequestration repositories as underground landfills has a great many benefits. First, there is a plethora of existing research and investigations that are directly analogous to geologic sequestration projects. Second, the regulatory framework is rather mature and can be easily adapted to serve geologic sequestration. This paper conducts an extensive literature search of the environmental, waste, and geologic sequestration literature to ascertain planning, design, and operational methodologies, lessons learned, and concepts that are directly useful for geologic sequestration to improve the technical and regulatory framework. Lastly, the paper uses a hypothetical underground landfill geologic sequestration site (ULGSS) in Florida, USA to discuss some of the findings and implications from the literature. It is concluded that there are a number of literature findings from the waste and environmental arena that should be adapted for geologic sequestration.

  20. Atlastin regulates store-operated calcium entry for nerve growth factor-induced neurite outgrowth.

    Science.gov (United States)

    Li, Jing; Yan, Bing; Si, Hongjiang; Peng, Xu; Zhang, Shenyuan L; Hu, Junjie

    2017-02-27

    Homotypic membrane fusion of the endoplasmic reticulum (ER) is mediated by a class of dynamin-like GTPases known as atlastin (ATL). Depletion of or mutations in ATL cause an unbranched ER morphology and hereditary spastic paraplegia (HSP), a neurodegenerative disease characterized by axon shortening in corticospinal motor neurons and progressive spasticity of the lower limbs. How ER shaping is linked to neuronal defects is poorly understood. Here, we show that dominant-negative mutants of ATL1 in PC-12 cells inhibit nerve growth factor (NGF)-induced neurite outgrowth. Overexpression of wild-type or mutant ATL1 or depletion of ATLs alters ER morphology and affects store-operated calcium entry (SOCE) by decreasing STIM1 puncta formation near the plasma membrane upon calcium depletion of the ER. In addition, blockage of the STIM1-Orai pathway effectively abolishes neurite outgrowth of PC-12 cells stimulated by NGF. These results suggest that SOCE plays an important role in neuronal regeneration, and mutations in ATL1 may cause HSP, partly by undermining SOCE.

  1. TMI-2 reactor vessel head removal

    Energy Technology Data Exchange (ETDEWEB)

    Bengel, P.R.; Smith, M.D.; Estabrook, G.A.

    1985-09-01

    This report describes the safe removal and storage of the Three Mile Island Unit 2 (TMI-2) reactor vessel head. The head was removed in July 1984 to permit the removal of the plenum and the reactor core, which were damaged during the 1979 accident. From July 1982, plans and preparations were made using a standard head removal procedure modified by the necessary precautions and changes to account for conditions caused by the accident. After data acquisition, equipment and structure modifications, and training, the head was safely removed and stored; and the internals indexing fixture and a work platform were installed on top of the vessel. Dose rates during and after the operation were lower than expected; lessons were learned from the operation which will be applied to the continuing fuel removal operations activities.

  2. TMI-2 reactor vessel head removal

    Energy Technology Data Exchange (ETDEWEB)

    Bengel, P.R.; Smith, M.D.; Estabrook, G.A.

    1984-12-01

    This report describes the safe removal and storage of the Three Mile Island Unit 2 reactor vessel head. The head was removed in July 1984 to permit the removal of the plenum and the reactor core, which were damaged during the 1979 accident. From July 1982, plans and preparations were made using a standard head removal procedure modified by the necessary precautions and changes to account for conditions caused by the accident. After data acquisition, equipment and structure modifications, and training the head was safely removed and stored and the internals indexing fixture and a work platform were installed on top of the vessel. Dose rates during and after the operation were lower than expected; lessons were learned from the operation which will be applied to the continuing fuel removal operations activities.

  3. 36 CFR 13.1150 - Is a permit required for a vessel in Glacier Bay?

    Science.gov (United States)

    2010-07-01

    ... vessel in Glacier Bay? 13.1150 Section 13.1150 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK SYSTEM UNITS IN ALASKA Special Regulations-Glacier Bay National Park and Preserve Vessel Permits § 13.1150 Is a permit required for a vessel in Glacier Bay? A permit from...

  4. 75 FR 17755 - Certificate of Alternative Compliance for the Offshore Supply Vessel C-ATLAS

    Science.gov (United States)

    2010-04-07

    ... SECURITY Coast Guard Certificate of Alternative Compliance for the Offshore Supply Vessel C-ATLAS AGENCY... Compliance was issued for the offshore supply vessel C-ATLAS as required by 33 U.S.C. 1605(c) and 33 CFR 81... Regulations, Parts 81 and 89, has been issued for the offshore supply vessel C-ATLAS. Full compliance with 72...

  5. 76 FR 79764 - Requested Administrative Waiver of the Coastwise Trade Laws: Vessel DREAM CATCHER; Invitation for...

    Science.gov (United States)

    2011-12-22

    ... Maritime Administration Requested Administrative Waiver of the Coastwise Trade Laws: Vessel DREAM CATCHER... the vessel DREAM CATCHER is: INTENDED COMMERCIAL USE OF VESSEL: ``Passenger charter.'' GEOGRAPHIC... given in Sec. 388.4 of MARAD's regulations at 46 CFR Part 388. Privacy Act Anyone is able to search the...

  6. Hawaii Abandoned Vessel Inventory, Kauai

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Abandoned Vessel Project Data for Kauai. Abandoned vessels pose a significant threat to the NOAA Trust resources through physical destruction of coral habitats...

  7. CNMI Abandoned Vessel Inventory, Tinian

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Abandoned Vessel Project Data for Tinian. Abandoned vessels pose a significant threat to the NOAA Trust resources through physical destruction of coral habitats...

  8. Puerto Rico Abandoned Vessel Inventory

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Abandoned Vessel Project Data for Puerto Rico. Abandoned vessels pose a significant threat to the NOAA Trust resources through physical destruction of coral...

  9. American Samoa Abandoned Vessel Inventory

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Abandoned Vessel Project Data for American Samoa. Abandoned vessels pose a significant threat to the NOAA Trust resources through physical destruction of coral...

  10. Hawaii Abandoned Vessel Inventory, Oahu

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Abandoned Vessel Project Data for Oahu, Hawaii. Abandoned vessels pose a significant threat to the NOAA Trust resources through physical destruction of coral...

  11. Hawaii Abandoned Vessel Inventory, Molokai

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Abandoned Vessel Project Data for Molokai, Hawaii. Abandoned vessels pose a significant threat to the NOAA Trust resources through physical destruction of coral...

  12. CNMI Abandoned Vessel Inventory, Rota

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Abandoned Vessel Project Data for Rota. Abandoned vessels pose a significant threat to the NOAA Trust resources through physical destruction of coral habitats...

  13. Hawaii Abandoned Vessel Inventory, Lanai

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Abandoned Vessel Project Data for Lanai. Abandoned vessels pose a significant threat to the NOAA Trust resources through physical destruction of coral habitats...

  14. For-Hire Vessel Directory

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Vessel Directory is maintained as the sample frame for the For-Hire Survey. I contains data on for-hire vessels on the Atlantic and Gulf coasts. Data include...

  15. CNMI Abandoned Vessel Inventory, Saipan

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Abandoned Vessel Project Data for Saipan. Abandoned vessels pose a significant threat to the NOAA Trust resources through physical destruction of coral habitats...

  16. Hawaii Abandoned Vessel Inventory, Maui

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Abandoned Vessel Project Data for Maui. Abandoned vessels pose a significant threat to the NOAA Trust resources through physical destruction of coral habitats...

  17. Vessels in Transit - Web Tool

    Data.gov (United States)

    Department of Transportation — A web tool that provides real-time information on vessels transiting the Saint Lawrence Seaway. Visitors may sort by order of turn, vessel name, or last location in...

  18. Detection of Blood Vessels in Retinal Fundus Images

    Directory of Open Access Journals (Sweden)

    Faraz Oloumi

    2014-07-01

    Full Text Available Detection of blood vessels in retinal fundus images is an important initial step in the development of systems for computer-aided diagnosis of pathologies of the eye. In this study, we perform multifeature analysis for the detection of blood vessels in retinal fundus images. The vessel detection techniques implemented include multiscale vesselness measures, Gabor filters, line operators, and matched filters. The selection of an appropriate threshold is crucial for accurate detection of retinal blood vessels. We evaluate an adaptive threshold selection method along with several others for this purpose. We also propose a postprocessing technique for removal of false-positive pixels around the optic nerve head. Values of the area under the receiver operating haracteristic curve of up to $0.961$ were obtained using the $20$ test images of the DRIVE database.

  19. Multiobjective Optimization Based Vessel Collision Avoidance Strategy Optimization

    Directory of Open Access Journals (Sweden)

    Qingyang Xu

    2014-01-01

    Full Text Available The vessel collision accidents cause a great loss of lives and property. In order to reduce the human fault and greatly improve the safety of marine traffic, collision avoidance strategy optimization is proposed to achieve this. In the paper, a multiobjective optimization algorithm NSGA-II is adopted to search for the optimal collision avoidance strategy considering the safety as well as economy elements of collision avoidance. Ship domain and Arena are used to evaluate the collision risk in the simulation. Based on the optimization, an optimal rudder angle is recommended to navigator for collision avoidance. In the simulation example, a crossing encounter situation is simulated, and the NSGA-II searches for the optimal collision avoidance operation under the Convention on the International Regulations for Preventing Collisions at Sea (COLREGS. The simulation studies exhibit the validity of the method.

  20. Pressure vessel design manual

    Energy Technology Data Exchange (ETDEWEB)

    Moss, D.R.

    1987-01-01

    The first section of the book covers types of loadings, failures, and stress theories, and how they apply to pressure vessels. The book delineates the procedures for designing typical components as well as those for designing large openings in cylindrical shells, ring girders, davits, platforms, bins and elevated tanks. The techniques for designing conical transitions, cone-cylinder intersections, intermediate heads, flat heads, and spherically dished covers are also described. The book covers the design of vessel supports subject to wind and seismic loads and one section is devoted to the five major ways of analyzing loads on shells and heads. Each procedure is detailed enough to size all welds, bolts, and plate thicknesses and to determine actual stresses.

  1. 77 FR 55439 - Vessel Traffic Service Updates, Including Establishment of Vessel Traffic Service Requirements...

    Science.gov (United States)

    2012-09-10

    ... SOLAS Convention since 2004. Because AIS carriage is required by regulation under 33 CFR 164.46 for... Waterway Safety Assessment PAWSS Port and Waterways Safety System PWSA Ports and Waterways Safety Act SOLAS International Convention for the Safety of Life at Sea U.S.C. United States Code VTM Vessel Traffic Management...

  2. 33 CFR 96.370 - What are the requirements for vessels of countries not party to Chapter IX of SOLAS?

    Science.gov (United States)

    2010-07-01

    ... OPERATION OF VESSELS AND SAFETY MANAGEMENT SYSTEMS How Will Safety Management Systems Be Certificated and...) Each foreign vessel which carries more than 12 passengers, or is a tanker, bulk freight vessel, freight... documentation showing that the vessel's company has a safety management system which was audited and assessed...

  3. Large vessel vasculitides

    OpenAIRE

    Morović-Vergles, Jadranka; Pukšić, Silva; Gudelj Gračanin, Ana

    2013-01-01

    Large vessel vasculitis includes Giant cell arteritis and Takayasu arteritis. Giant cell arteritis is the most common form of vasculitis affect patients aged 50 years or over. The diagnosis should be considered in older patients who present with new onset of headache, visual disturbance, polymyalgia rheumatica and/or fever unknown cause. Glucocorticoides remain the cornerstone of therapy. Takayasu arteritis is a chronic panarteritis of the aorta ant its major branches presenting commonly in y...

  4. Very Versatile Vessel

    Science.gov (United States)

    2009-09-01

    data. This source provides information on aluminum hydrofoil vessels without the added weight of foil structures. The composite armor around the...seating compartment. The sides should also limit wave splash on the deck. The freeboard should contribute reserve buoyancy , increasing large-angle and...Resistance, Powering, and Propulsion Savitsky’s Method Since model testing data or other reliable performance data was unavailable for the proposed

  5. Standard Operating Procedures, ethical and legal regulations in BTB (Brain/Tissue/Bio) banking: what is still missing?

    Science.gov (United States)

    Ravid, Rivka

    2008-06-01

    The use of human biological specimens in scientific research is the focus of current international public and professional concern and a major issue in bioethics in general. Brain/Tissue/Bio banks (BTB-banks) are a rapid developing sector; each of these banks acts locally as a steering unit for the establishment of the local Standard Operating Procedures (SOPs) and the legal regulations and ethical guidelines to be followed in the procurement and dissemination of research specimens. An appropriat Code of Conduct is crucial to a successful operation of the banks and the research application they handle. What are we still missing ? (1) Adequate funding for research BTB-banks. (2) Standard evaluation protocls for audit of BTB-bank performance. (3) Internationally accepted SOP's which will facilitate exchange and sharing of specimens and data with the scientific community. (4) Internationally accepted Code of Conduct. In the present paper we review the most pressing organizational, methodological, medico-legal and ethical issues involved in BTB-banking; funding, auditing, procurement, management/handling, dissemination and sharing of specimens, confidentiality and data protection, genetic testing, "financial gain" and safety measures. Taking into consideration the huge variety of the specimens stored in different repositories and the enormous differences in medico-legal systems and ethics regulations in different countries it is strongly recommend that the health-care systems and institutions who host BTB-Banks will put more efforts in getting adequate funding for the infrastructure and daily activities. The BTB-banks should define evaluation protocols, SOPs and their Code of Conduct. This in turn will enable the banks to share the collected specimens and data with the largest possible number of researchers and aim at a maximal scientific spin-off and advance in public health research.

  6. Dystrophin/α1-syntrophin scaffold regulated PLC/PKC-dependent store-operated calcium entry in myotubes.

    Science.gov (United States)

    Sabourin, Jessica; Harisseh, Rania; Harnois, Thomas; Magaud, Christophe; Bourmeyster, Nicolas; Déliot, Nadine; Constantin, Bruno

    2012-12-01

    In skeletal muscles from patient suffering of Duchenne Muscular Dystrophy and from mdx mice, the absence of the cytoskeleton protein dystrophin has been shown to be essential for maintaining a normal calcium influx. We showed that a TRPC store-dependent cation influx is increased by loss of dystrophin or a scaffolding protein α1-syntrophin, however the mechanisms of this calcium mishandling are incompletely understood. First of all, we confirmed that TRPC1 but also STIM1 and Orai1 are supporting the store-operated cation entry which is enhanced in dystrophin-deficient myotubes. Next, we demonstrated that inhibition of PLC or PKC in dystrophin-deficient myotubes restores elevated cation entry to normal levels similarly to enforced minidystrophin expression. In addition, silencing α1-syntrophin also increased cation influx in a PLC/PKC dependent pathway. We also showed that α1-syntrophin and PLCβ are part of a same protein complex reinforcing the idea of their inter-relation in calcium influx regulation. This elevated cation entry was decreased to normal levels by chelating intracellular free calcium with BAPTA-AM. Double treatments with BAPTA-AM and PLC or PKC inhibitors suggested that the elevation of cation influx by PLC/PKC pathway is dependent on cytosolic calcium. All these results demonstrate an involvement in dystrophin-deficient myotubes of a specific calcium/PKC/PLC pathway in elevation of store-operated cation influx supported by the STIM1/Orai1/TRPC1 proteins, which is normally regulated by the α1-syntrophin/dystrophin scaffold. Copyright © 2012 Elsevier Ltd. All rights reserved.

  7. Low temperature heating floors: impact of end-regulation on the operation of the main regulation; PCBT: incidence de la regulation terminale sur le fonctionnement de la regulation centrale

    Energy Technology Data Exchange (ETDEWEB)

    Didier, G.

    2003-10-01

    This study shows that it is necessary to keep a nominal flow rate in the open loops of a low temperature heating floor when only the end-regulation systems are used to regulate the heat supplies, and this whatever the flow rate inside the other loops. (J.S.)

  8. Interplay between Inflammatory Responses and Lymphatic Vessels

    OpenAIRE

    Shin, Kihyuk; Lee, Seung-Hyo

    2014-01-01

    Lymphatic vessels are routes for leukocyte migration and fluid drainage. In addition to their passive roles in migration of leukocytes, increasing evidence indicates their active roles in immune regulation. Tissue inflammation rapidly induces lymphatic endothelial cell proliferation and chemokine production, thereby resulting in lymphangiogenesis. Furthermore, lymphatic endothelial cells induce T cell tolerance through various mechanisms. In this review, we focus on the current knowledge on h...

  9. Active and inactive enhancers co-operate to exert localized and long-range control of gene regulation

    Science.gov (United States)

    Proudhon, Charlotte; Snetkova, Valentina; Raviram, Ramya; Lobry, Camille; Badri, Sana; Jiang, Tingting; Hao, Bingtao; Trimarchi, Thomas; Kluger, Yuval; Aifantis, Iannis; Bonneau, Richard; Skok, Jane A

    2016-01-01

    V(D)J recombination relies on the presence of proximal enhancers that activate the antigen receptor (AgR) loci in a lineage and stage specific manner. Unexpectedly we find that both active and inactive AgR enhancers co-operate to disseminate their effects in a localized and long-range manner. Here we demonstrate the importance of short-range contacts between active enhancers that constitute an Igk super-enhancer in B cells. Deletion of one element reduces the interaction frequency between other enhancers in the hub, which compromises the transcriptional output of each component. We further establish that in T cells long-range contact and co-operation between the inactive Igk enhancer, MiEκ and the active Tcrb enhancer, Eβ, alters enrichment of CBFβ binding in a manner that impacts Tcrb recombination. These findings underline the complexities of enhancer regulation and point to a role for localized and long-range enhancer-sharing between active and inactive elements in lineage and stage specific control. PMID:27239026

  10. 46 CFR 78.33-1 - Repairs of boiler and pressure vessels.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false Repairs of boiler and pressure vessels. 78.33-1 Section... OPERATIONS Reports of Accidents, Repairs, and Unsafe Equipment § 78.33-1 Repairs of boiler and pressure vessels. (a) Before making any repairs to boilers or unfired pressure vessels, the chief engineer shall...

  11. 33 CFR 105.270 - Security measures for delivery of vessel stores and bunkers.

    Science.gov (United States)

    2010-07-01

    ... vessel stores and bunkers. 105.270 Section 105.270 Navigation and Navigable Waters COAST GUARD... Requirements § 105.270 Security measures for delivery of vessel stores and bunkers. (a) General. The facility owner or operator must ensure that security measures relating to the delivery of vessel stores and...

  12. 46 CFR 27.205 - What are the requirements for internal communication systems on towing vessels?

    Science.gov (United States)

    2010-10-01

    ... requirements for internal communication systems on towing vessels? (a) You must ensure that your vessel is fitted with a communication system between the engine room and the operating station that— (1) Consists... electrical system on your towing vessel; and (2) Provides two-way voice communication and calling between the...

  13. 76 FR 16610 - Proposed Information Collection; Comment Request; Pacific Islands Region Vessel and Gear...

    Science.gov (United States)

    2011-03-24

    ... Islands Region Vessel and Gear Identification Requirements AGENCY: National Oceanic and Atmospheric... Western Pacific fishery management unit species display identification markings on the vessel and gear, as... require that certain fishing gear must be marked. In the pelagic longline fisheries, the vessel operator...

  14. 50 CFR 300.116 - Requirements for a vessel monitoring system for U.S. vessels.

    Science.gov (United States)

    2010-10-01

    ... procedures indicated on an installation and activation checklist, which is available from OLE; and (2) Submit to OLE a statement certifying compliance with the checklist, as prescribed on the checklist. (c... instructions from that office. If notified by NMFS that a vessel's VMS is not operating properly, the owner and...

  15. Lung vessel segmentation in CT images using graph-cuts

    Science.gov (United States)

    Zhai, Zhiwei; Staring, Marius; Stoel, Berend C.

    2016-03-01

    Accurate lung vessel segmentation is an important operation for lung CT analysis. Filters that are based on analyzing the eigenvalues of the Hessian matrix are popular for pulmonary vessel enhancement. However, due to their low response at vessel bifurcations and vessel boundaries, extracting lung vessels by thresholding the vesselness is not sufficiently accurate. Some methods turn to graph-cuts for more accurate segmentation, as it incorporates neighbourhood information. In this work, we propose a new graph-cuts cost function combining appearance and shape, where CT intensity represents appearance and vesselness from a Hessian-based filter represents shape. Due to the amount of voxels in high resolution CT scans, the memory requirement and time consumption for building a graph structure is very high. In order to make the graph representation computationally tractable, those voxels that are considered clearly background are removed from the graph nodes, using a threshold on the vesselness map. The graph structure is then established based on the remaining voxel nodes, source/sink nodes and the neighbourhood relationship of the remaining voxels. Vessels are segmented by minimizing the energy cost function with the graph-cuts optimization framework. We optimized the parameters used in the graph-cuts cost function and evaluated the proposed method with two manually labeled sub-volumes. For independent evaluation, we used 20 CT scans of the VESSEL12 challenge. The evaluation results of the sub-volume data show that the proposed method produced a more accurate vessel segmentation compared to the previous methods, with F1 score 0.76 and 0.69. In the VESSEL12 data-set, our method obtained a competitive performance with an area under the ROC curve of 0.975, especially among the binary submissions.

  16. Vessel Traffic Services.

    Science.gov (United States)

    1982-12-01

    Yorker" articles titled Silent Spring by Rachel Carson in 1963 produced a unifying effect, "the sort of rallying point of the movement to protect the...6232, 92d Cong., 1st. sess., 1971, p. 2. 15. Carson , Rachel L. , The Sea Around Us, New York: Oxford Univesity Press, 195-, p. IV. 16. U.S., Congress...Government Printing Office, 1974. 63. Buhler, L. and Geiger, J., Vessel Traffic Data Extraction MethodoloqX, Silver Spring , Maryland, O6erFae-tns

  17. Vanishing corneal vessels

    Science.gov (United States)

    Nicholson, Luke; Chana, Rupinder

    2013-01-01

    We wish to highlight the importance of acknowledging the accompanying effects of topical phenylephrine drops on the eye other than its intended mydriasis. We reported a case of a 92-year-old woman with a corneal graft who was noted to have superficial corneal vascularisation which was not documented previously. After the instillation of topical tropicamide 1% and phenylephrine 2.5%, for funduscopy, the corneal vascularisation was not visible. When reassessed on another visit, tropicamide had no effect on the vessels and only phenylephrine did. We wish to highlight that when reviewing patients in cornea clinics, instilling phenylephrine prior to being seen may mask important corneal vascularisation. PMID:24121816

  18. 77 FR 14276 - Regulated Navigation Area; Little Bay Bridge Construction, Little Bay, Portsmouth, NH

    Science.gov (United States)

    2012-03-09

    ...The Coast Guard is establishing a regulated navigation area (RNA) on the navigable waters of Little Bay in the Piscataqua River under and surrounding the Little Bay and General Sullivan Bridges in order to facilitate construction of the Little Bay Bridge between Newington, NH and Dover, NH. This temporary interim rule is necessary to provide for the safety of life on the navigable waters during bridge construction operations that could pose an imminent hazard to vessels operating in the area. This rule implements certain safety measures, including speed restrictions and the temporary suspension of vessel traffic during construction operations.

  19. Blood flow reprograms lymphatic vessels to blood vessels.

    Science.gov (United States)

    Chen, Chiu-Yu; Bertozzi, Cara; Zou, Zhiying; Yuan, Lijun; Lee, John S; Lu, MinMin; Stachelek, Stan J; Srinivasan, Sathish; Guo, Lili; Vicente, Andres; Vincente, Andres; Mericko, Patricia; Levy, Robert J; Makinen, Taija; Oliver, Guillermo; Kahn, Mark L

    2012-06-01

    Human vascular malformations cause disease as a result of changes in blood flow and vascular hemodynamic forces. Although the genetic mutations that underlie the formation of many human vascular malformations are known, the extent to which abnormal blood flow can subsequently influence the vascular genetic program and natural history is not. Loss of the SH2 domain-containing leukocyte protein of 76 kDa (SLP76) resulted in a vascular malformation that directed blood flow through mesenteric lymphatic vessels after birth in mice. Mesenteric vessels in the position of the congenital lymphatic in mature Slp76-null mice lacked lymphatic identity and expressed a marker of blood vessel identity. Genetic lineage tracing demonstrated that this change in vessel identity was the result of lymphatic endothelial cell reprogramming rather than replacement by blood endothelial cells. Exposure of lymphatic vessels to blood in the absence of significant flow did not alter vessel identity in vivo, but lymphatic endothelial cells exposed to similar levels of shear stress ex vivo rapidly lost expression of PROX1, a lymphatic fate-specifying transcription factor. These findings reveal that blood flow can convert lymphatic vessels to blood vessels, demonstrating that hemodynamic forces may reprogram endothelial and vessel identity in cardiovascular diseases associated with abnormal flow.

  20. Aged Lymphatic Vessels and Mast Cells in Perilymphatic Tissues.

    Science.gov (United States)

    Pal, Sarit; Meininger, Cynthia J; Gashev, Anatoliy A

    2017-05-03

    This review provides a comprehensive summary of research on aging-associated alterations in lymphatic vessels and mast cells in perilymphatic tissues. Aging alters structure (by increasing the size of zones with low muscle cell investiture), ultrastructure (through loss of the glycocalyx), and proteome composition with a concomitant increase in permeability of aged lymphatic vessels. The contractile function of aged lymphatic vessels is depleted with the abolished role of nitric oxide and an increased role of lymphatic-born histamine in flow-dependent regulation of lymphatic phasic contractions and tone. In addition, aging induces oxidative stress in lymphatic vessels and facilitates the spread of pathogens from these vessels into perilymphatic tissues. Aging causes the basal activation of perilymphatic mast cells, which, in turn, restricts recruitment/activation of immune cells in perilymphatic tissues. This aging-associated basal activation of mast cells limits proper functioning of the mast cell/histamine/NF-κB axis that is essential for the regulation of lymphatic vessel transport and barrier functions as well as for both the interaction and trafficking of immune cells near and within lymphatic collecting vessels. Cumulatively, these changes play important roles in the pathogenesis of alterations in inflammation and immunity associated with aging.

  1. Design and analysis of multicavity prestressed concrete reactor vessels. [HTGR

    Energy Technology Data Exchange (ETDEWEB)

    Goodpasture, D.W.; Burdette, E.G.; Callahan, J.P.

    1977-01-01

    During the past 25 years, a rather rapid evolution has taken place in the design and use of prestressed concrete reactor vessels (PCRVs). Initially the concrete vessel served as a one-to-one replacement for its steel counterpart. This was followed by the development of the integral design which led eventually to the more recent multicavity vessel concept. Although this evolution has seen problems in construction and operation, a state-of-the-art review which was recently conducted by the Oak Ridge National Laboratory indicated that the PCRV has proven to be a satisfactory and inherently safe type of vessel for containment of gas-cooled reactors from a purely functional standpoint. However, functionalism is not the only consideration in a demanding and highly competitive industry. A summary is presented of the important considerations in the design and analysis of multicavity PCRVs together with overall conclusions concerning the state of the art of these vessels.

  2. Regulation of fibrinolysis by C-terminal lysines operates through plasminogen and plasmin but not tissue-type plasminogen activator.

    Science.gov (United States)

    Silva, M M C G; Thelwell, C; Williams, S C; Longstaff, C

    2012-11-01

    Binding of tissue-type plasminogen (Pgn) activator (t-PA) and Pgn to fibrin regulates plasmin generation, but there is no consistent, quantitative understanding of the individual contribution of t-PA finger and kringle 2 domains to the regulation of fibrinolysis. Kringle domains bind to lysines in fibrin, and this interaction can be studied by competition with lysine analogs and removal of C-terminal lysines by carboxypeptidase B (CPB). High-throughput, precise clot lysis assays incorporating the lysine analog tranexamic acid (TA) or CPB and genetically engineered variants of t-PA were performed. In particular, wild-type (WT) t-PA (F-G-K1-K2-P) and a domain-switched variant K1K1t-PA (F-G-K1-K1-P) that lacks kringle 2 but retains normal t-PA structure were compared to probe the importance of fibrin lysine binding by t-PA kringle 2. WT t-PA showed higher rates of fibrinolysis than K1K1t-PA, but the inhibitory effects of TA or CPB were very similar for WT t-PA and the variant t-PA (fibrinolysis was also inhibited by TA, even though Pgn activation could be stimulated. Fibrin treated with factor XIIIa (FXIIIa) generates crosslinked degradation products, but these did not affect the results obtained with WT t-PA and K1K1t-PA. t-PA kringle 2 has a minor role in the initial interaction of t-PA and fibrin, but stimulation of fibrinolysis by C-terminal lysines (or inhibition by carboxypeptidases or TA) operates through Pgn and plasmin binding, not through t-PA. This is also true when fibrin is crosslinked by treatment with FXIIIa. © 2012 International Society on Thrombosis and Haemostasis.

  3. Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function.

    Science.gov (United States)

    Concepcion, Axel R; Vaeth, Martin; Wagner, Larry E; Eckstein, Miriam; Hecht, Lee; Yang, Jun; Crottes, David; Seidl, Maximilian; Shin, Hyosup P; Weidinger, Carl; Cameron, Scott; Turvey, Stuart E; Issekutz, Thomas; Meyts, Isabelle; Lacruz, Rodrigo S; Cuk, Mario; Yule, David I; Feske, Stefan

    2016-11-01

    Eccrine sweat glands are essential for sweating and thermoregulation in humans. Loss-of-function mutations in the Ca2+ release-activated Ca2+ (CRAC) channel genes ORAI1 and STIM1 abolish store-operated Ca2+ entry (SOCE), and patients with these CRAC channel mutations suffer from anhidrosis and hyperthermia at high ambient temperatures. Here we have shown that CRAC channel-deficient patients and mice with ectodermal tissue-specific deletion of Orai1 (Orai1K14Cre) or Stim1 and Stim2 (Stim1/2K14Cre) failed to sweat despite normal sweat gland development. SOCE was absent in agonist-stimulated sweat glands from Orai1K14Cre and Stim1/2K14Cre mice and human sweat gland cells lacking ORAI1 or STIM1 expression. In Orai1K14Cre mice, abolishment of SOCE was associated with impaired chloride secretion by primary murine sweat glands. In human sweat gland cells, SOCE mediated by ORAI1 was necessary for agonist-induced chloride secretion and activation of the Ca2+-activated chloride channel (CaCC) anoctamin 1 (ANO1, also known as TMEM16A). By contrast, expression of TMEM16A, the water channel aquaporin 5 (AQP5), and other regulators of sweat gland function was normal in the absence of SOCE. Our findings demonstrate that Ca2+ influx via store-operated CRAC channels is essential for CaCC activation, chloride secretion, and sweat production in humans and mice.

  4. The vessel fluence; Fluence cuve

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    This book presents the proceedings of the technical meeting on the reactors vessels fluence. They are grouped in eight sessions: the industrial context and the stakes of the vessels control; the organization and the methodology for the fluence computation; the concerned physical properties; the reference computation methods; the fluence monitoring in an industrial context; vessels monitoring under irradiation; others methods in the world; the research and development programs. (A.L.B.)

  5. [Large vessel vasculitides].

    Science.gov (United States)

    Morović-Vergles, Jadranka; Puksić, Silva; Gracanin, Ana Gudelj

    2013-01-01

    Large vessel vasculitis includes Giant cell arteritis and Takayasu arteritis. Giant cell arteritis is the most common form of vasculitis affect patients aged 50 years or over. The diagnosis should be considered in older patients who present with new onset of headache, visual disturbance, polymyalgia rheumatica and/or fever unknown cause. Glucocorticoides remain the cornerstone of therapy. Takayasu arteritis is a chronic panarteritis of the aorta ant its major branches presenting commonly in young ages. Although all large arteries can be affected, the aorta, subclavian and carotid arteries are most commonly involved. The most common symptoms included upper extremity claudication, hypertension, pain over the carotid arteries (carotidynia), dizziness and visual disturbances. Early diagnosis and treatment has improved the outcome in patients with TA.

  6. Americium behaviour in plastic vessels

    Energy Technology Data Exchange (ETDEWEB)

    Legarda, F.; Herranz, M. [Departamento de Ingenieria Nuclear y Mecanica de Fluidos, Escuela Tecnica Superior de Ingenieria de Bilbao, Universidad del Pais Vasco (UPV/EHU), Alameda de Urquijo s/n, 48013 Bilbao (Spain); Idoeta, R., E-mail: raquel.idoeta@ehu.e [Departamento de Ingenieria Nuclear y Mecanica de Fluidos, Escuela Tecnica Superior de Ingenieria de Bilbao, Universidad del Pais Vasco (UPV/EHU), Alameda de Urquijo s/n, 48013 Bilbao (Spain); Abelairas, A. [Departamento de Ingenieria Nuclear y Mecanica de Fluidos, Escuela Tecnica Superior de Ingenieria de Bilbao, Universidad del Pais Vasco (UPV/EHU), Alameda de Urquijo s/n, 48013 Bilbao (Spain)

    2010-07-15

    The adsorption of {sup 241}Am dissolved in water in different plastic storage vessels was determined. Three different plastics were investigated with natural and distilled waters and the retention of {sup 241}Am by these plastics was studied. The same was done by varying vessel agitation time, vessel agitation speed, surface/volume ratio of water in the vessels and water pH. Adsorptions were measured to be between 0% and 70%. The adsorption of {sup 241}Am is minimized with no water agitation, with PET or PVC plastics, and by water acidification.

  7. Role of arginase in vessel wall remodeling

    Directory of Open Access Journals (Sweden)

    William eDurante

    2013-05-01

    Full Text Available Arginase metabolizes the semi-essential amino acid L-arginine to L-ornithine and urea. There are two distinct isoforms of arginase, arginase I and II, which are encoded by separate genes and display differences in tissue distribution, subcellular localization, and molecular regulation. Blood vessels express both arginase I and II but their distribution appears to be cell-, vessel-, and species-specific. Both isoforms of arginase are induced by numerous pathologic stimuli and contribute to vascular cell dysfunction and vessel wall remodeling in several diseases. Clinical and experimental studies have documented increases in the expression and/or activity of arginase I or II in blood vessels following arterial injury and in pulmonary and arterial hypertension, aging, and atherosclerosis. Significantly, pharmacological inhibition or genetic ablation of arginase in animals ameliorates abnormalities in vascular cells and normalizes blood vessel architecture and function in all of these pathological states. The detrimental effect of arginase in vascular remodeling is attributable to its ability to stimulate vascular smooth muscle cell and endothelial cell proliferation, and collagen deposition by promoting the synthesis of polyamines and L-proline, respectively. In addition, arginase adversely impacts arterial remodeling by directing macrophages towards an inflammatory phenotype. Moreover, the proliferative, fibrotic, and inflammatory actions of arginase in the vasculature are further amplified by its capacity to inhibit nitric oxide synthesis by competing with nitric oxide synthase for substrate, L-arginine. Pharmacologic or molecular approaches targeting specific isoforms of arginase represent a promising strategy in treating obstructive fibroproliferative vascular disease.

  8. 78 FR 59231 - Regulated Navigation Area-Tappan Zee Bridge Construction Project, Hudson River; South Nyack and...

    Science.gov (United States)

    2013-09-26

    ...The Coast Guard is establishing a regulated navigation area (RNA) on the navigable waters of the Hudson River surrounding the Tappan Zee Bridge. This temporary interim rule allows the Coast Guard to enforce speed and wake restrictions and prohibit all vessel traffic through the RNA during bridge replacement operations, both planned and unforeseen, that could pose an imminent hazard to persons and vessels operating in the area. This rule is necessary to provide for the safety of life in the regulated area during the construction of the bridge.

  9. Firefighter's compressed air breathing system pressure vessel development program

    Science.gov (United States)

    Beck, E. J.

    1974-01-01

    The research to design, fabricate, test, and deliver a pressure vessel for the main component in an improved high-performance firefighter's breathing system is reported. The principal physical and performance characteristics of the vessel which were required are: (1) maximum weight of 9.0 lb; (2) maximum operating pressure of 4500 psig (charge pressure of 4000 psig); (3) minimum contained volume of 280 in. 3; (4) proof pressure of 6750 psig; (5) minimum burst pressure of 9000 psig following operational and service life; and (6) a minimum service life of 15 years. The vessel developed to fulfill the requirements described was completely sucessful, i.e., every category of performence was satisfied. The average weight of the vessel was found to be about 8.3 lb, well below the 9.0 lb specification requirement.

  10. Processing and analysis techniques involving in-vessel material generation

    Science.gov (United States)

    Schabron, John F [Laramie, WY; Rovani, Jr., Joseph F.

    2011-01-25

    In at least one embodiment, the inventive technology relates to in-vessel generation of a material from a solution of interest as part of a processing and/or analysis operation. Preferred embodiments of the in-vessel material generation (e.g., in-vessel solid material generation) include precipitation; in certain embodiments, analysis and/or processing of the solution of interest may include dissolution of the material, perhaps as part of a successive dissolution protocol using solvents of increasing ability to dissolve. Applications include, but are by no means limited to estimation of a coking onset and solution (e.g., oil) fractionating.

  11. Analysis and Visualization of Nerve Vessel Contacts for Neurovascular Decompression

    Science.gov (United States)

    Süßmuth, Jochen; Piazza, Alexander; Enders, Frank; Naraghi, Ramin; Greiner, Günther; Hastreiter, Peter

    Neurovascular compression syndromes are caused by a pathological contact between cranial nerves and vascular structures at the surface of the brainstem. Aiming at improved pre-operative analysis of the target structures, we propose calculating distance fields to provide quantitative information of the important nerve-vessel contacts. Furthermore, we suggest reconstructing polygonal models for the nerves and vessels. Color-coding with the respective distance information is used for enhanced visualization. Overall, our new strategy contributes to a significantly improved clinical understanding.

  12. Using SA508/533 for the HTGR Vessel Material

    Energy Technology Data Exchange (ETDEWEB)

    Larry Demick

    2012-06-01

    This paper examines the influence of High Temperature Gas-cooled Reactor (HTGR) module power rating and normal operating temperatures on the use of SA508/533 material for the HTGR vessel system with emphasis on the calculated times at elevated temperatures approaching or exceeding ASME Code Service Limits (Levels B&C) to which the reactor pressure vessel could be exposed during postulated pressurized and depressurized conduction cooldown events over its design lifetime.

  13. Analysis and Measurement of NOx Emissions in Port Auxiliary Vessels

    Directory of Open Access Journals (Sweden)

    German de Melo Rodriguez

    2013-09-01

    Full Text Available This paper is made NOx pollution emitted by port auxiliary vessels, specifically by harbour tugs, due to its unique operating characteristics of operation, require a large propulsion power changes discontinuously, also possess some peculiar technical characteristics, large tonnage and high propulsive power, that differentiate them from other auxiliary vessels of the port. Taking into account all the above features, there are no studies of the NOx emission engines caused by different working regimes of power because engine manufacturers have not measured these emissions across the range of operating power, but usually we only report the pollution produced by its engines to a maximum continuous power.

  14. Role of PFKFB3-driven glycolysis in vessel sprouting.

    Science.gov (United States)

    De Bock, Katrien; Georgiadou, Maria; Schoors, Sandra; Kuchnio, Anna; Wong, Brian W; Cantelmo, Anna Rita; Quaegebeur, Annelies; Ghesquière, Bart; Cauwenberghs, Sandra; Eelen, Guy; Phng, Li-Kun; Betz, Inge; Tembuyser, Bieke; Brepoels, Katleen; Welti, Jonathan; Geudens, Ilse; Segura, Inmaculada; Cruys, Bert; Bifari, Franscesco; Decimo, Ilaria; Blanco, Raquel; Wyns, Sabine; Vangindertael, Jeroen; Rocha, Susana; Collins, Russel T; Munck, Sebastian; Daelemans, Dirk; Imamura, Hiromi; Devlieger, Roland; Rider, Mark; Van Veldhoven, Paul P; Schuit, Frans; Bartrons, Ramon; Hofkens, Johan; Fraisl, Peter; Telang, Sucheta; Deberardinis, Ralph J; Schoonjans, Luc; Vinckier, Stefan; Chesney, Jason; Gerhardt, Holger; Dewerchin, Mieke; Carmeliet, Peter

    2013-08-01

    Vessel sprouting by migrating tip and proliferating stalk endothelial cells (ECs) is controlled by genetic signals (such as Notch), but it is unknown whether metabolism also regulates this process. Here, we show that ECs relied on glycolysis rather than on oxidative phosphorylation for ATP production and that loss of the glycolytic activator PFKFB3 in ECs impaired vessel formation. Mechanistically, PFKFB3 not only regulated EC proliferation but also controlled the formation of filopodia/lamellipodia and directional migration, in part by compartmentalizing with F-actin in motile protrusions. Mosaic in vitro and in vivo sprouting assays further revealed that PFKFB3 overexpression overruled the pro-stalk activity of Notch, whereas PFKFB3 deficiency impaired tip cell formation upon Notch blockade, implying that glycolysis regulates vessel branching. Copyright © 2013 Elsevier Inc. All rights reserved.

  15. Safety assessment and environmental impact assessment: Application to regulation of nuclear and radiation safety, with special consideration to Lepse related operations

    Energy Technology Data Exchange (ETDEWEB)

    Makarov, V.G. [Gosatomnadzor (Russian Federation); Smith, G.M.; Stone, D.M. [QuantiSci Ltd., Henley-on-Thames (United Kingdom)

    2000-11-01

    This report discusses the links between safety assessment and environmental impact assessment as applied to operations for unloading of spent nuclear fuel from the Lepse storage vessel. Regulatory responsibilities and regulatory requirements in these areas are under discussion and development in the Russian Federation and in other countries. The authors provide a briefing, based on inputs from Russian and western organisations, of their understanding of the situation at the time the work was done. They also make a variety of suggestions according to their perspectives. These suggestions should be relevant to the Lepse situation and to some other nuclear activities, bur do not represent the position of any particular organisation. Accordingly, this report is published by the SSI with the intention to promote discussion and interaction among relevant authorities.

  16. Final Report of the 2nd Ex-Vessel Neutron Dosimetry Installation And Evaluations for Kori Unit 1 Reactor Pressure Vessel

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Byoung Chul; Yoo, Choon Sung; Lee, Sam Lai; Chang, Kee Ok; Gong, Un Sik; Choi, Kwon Jae; Chang, Jong Hwa; Kim, Kwan Hyun; Hong, Joon Wha

    2007-02-15

    This report describes a neutron fluence assessment performed for the Kori Unit 1 pressure vessel beltline region based on the guidance specified in Regulatory Guide 1.190. In this assessment, maximum fast neutron exposures expressed in terms of fast neutron fluence (E>1 MeV) and iron atom displacements (dpa) were established for the beltline region of the pressure vessel. After Cycle 22 of reactor operation, 2nd Ex-Vessel Neutron Dosimetry Program was instituted at Kori Unit 1 to provide continuous monitoring of the beltline region of the reactor vessel. The use of the Ex-Vessel Neutron Dosimetry Program coupled with available surveillance capsule measurements provides a plant specific data base that enables the evaluation of the vessel exposure and the uncertainty associated with that exposure over the service life of the unit. Ex-Vessel Neutron Dosimetry has been evaluated at the conclusion of Cycle 23.

  17. Final report for the 2nd Ex-Vessel Neutron Dosimetry Installations and Evaluations for Yonggwang Unit 2 Reactor Pressure Vessel

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Byoung Chul; Yoo, Choon Sung; Lee, Sam Lai; Gong, Un Sik; Choi, Kwon Jae; Chung, Kyoung Ki; Kim, Kwan Hyun; Chang, Jong Hwa; Ha, Jea Ju

    2008-01-15

    This report describes a neutron fluence assessment performed for the Yonggwang Unit 2 pressure vessel beltline region based on the guidance specified in Regulatory Guide 1.190. In this assessment, maximum fast neutron exposures expressed in terms of fast neutron fluence (E>1 MeV) and iron atom displacements (dpa) were established for the beltline region of the pressure vessel. During Cycle 16 of reactor operation, an Ex-Vessel Neutron Dosimetry Program was instituted at Yonggwang Unit 2 to provide continuous monitoring of the beltline region of the reactor vessel. The use of the Ex-Vessel Neutron Dosimetry Program coupled with available surveillance capsule measurements provides a plant specific data base that enables the evaluation of the vessel exposure and the uncertainty associated with that exposure over the service life of the unit. Ex-Vessel Neutron Dosimetry has been evaluated at the conclusion of Cycle 16.

  18. Final report for the 3rd Ex-Vessel Neutron Dosimetry Installations and Evaluations for Kori Unit 1 Reactor Pressure Vessel

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Byoung Chul; Yoo, Choon Sung; Lee, Sam Lai (and others)

    2008-03-15

    This report describes a neutron fluence assessment performed for the Kori Unit 1 pressure vessel belt line region based on the guidance specified in Regulatory Guide 1.190. In this assessment, maximum fast neutron exposures expressed in terms of fast neutron fluence (E>1 MeV) and iron atom displacements (dpa) were established for the belt line region of the pressure vessel. After Cycle 23 of reactor operation, 3rd Ex-Vessel Neutron Dosimetry Program was instituted at Kori Unit 1 to provide continuous monitoring of the belt line region of the reactor vessel. The use of the Ex-Vessel Neutron Dosimetry Program coupled with available surveillance capsule measurements provides a plant specific data base that enables the evaluation of the vessel exposure and the uncertainty associated with that exposure over the service life of the unit. Ex-Vessel Neutron Dosimetry has been evaluated at the conclusion of Cycle 24.

  19. Final report for the 1st ex-vessel neutron dosimetry installations and evaluations for Kori unit 2 reactor pressure vessel

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Byoung Chul; Yoo, Choon Sung; Lee, Sam Lai; Chang, Kee Ok; Gong, Un Sik; Choi, Kwon Jae; Chang, Jong Hwa; Lim, Nam Jin; Hong, Joon Wha; Cheon, Byeong Jin

    2006-11-15

    This report describes a neutron fluence assessment performed for the Kori unit 2 pressure vessel belt line region based on the guidance specified in regulatory guide 1.190. In this assessment, maximum fast neutron exposures expressed in terms of fast neutron fluence (E>1 MeV) and iron atom displacements (dpa) were established for the belt line region of the pressure vessel. During cycle 20 of reactor operation, an ex-vessel neutron dosimetry program was instituted at Kori unit 2 to provide continuous monitoring of the belt line region of the reactor vessel. The use of the ex-vessel neutron dosimetry program coupled with available surveillance capsule measurements provides a plant specific data base that enables the evaluation of the vessel exposure and the uncertainty associated with that exposure over the service life of the unit. Ex-vessel neutron dosimetry has been evaluated at the conclusion of cycle 20.

  20. Final Report of the 2nd Ex-Vessel Neutron Dosimetry Installation And Evaluations for Yonggwang Unit 1 Reactor Pressure Vessel

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Byoung Chul; Yoo, Choon Sung; Lee, Sam Lai; Gong, Un Sik; Choi, Kwon Jae; Chung, Kyoung Ki; Kim, Kwan Hyun; Chang, Jong Hwa; Ha, Jea Ju

    2008-01-15

    This report describes a neutron fluence assessment performed for the Kori Unit 2 pressure vessel belt line region based on the guidance specified in Regulatory Guide 1.190. In this assessment, maximum fast neutron exposures expressed in terms of fast neutron fluence (E>1 MeV) and iron atom displacements (dpa) were established for the belt line region of the pressure vessel. During Cycle 21 of reactor operation, an Ex-Vessel Neutron Dosimetry Program was instituted at Kori Unit 2 to provide continuous monitoring of the belt line region of the reactor vessel. The use of the Ex-Vessel Neutron Dosimetry Program coupled with available surveillance capsule measurements provides a plant specific data base that enables the evaluation of the vessel exposure and the uncertainty associated with that exposure over the service life of the unit. Ex-Vessel Neutron Dosimetry has been evaluated at the conclusion of Cycle 21.

  1. Advanced inflow forecasting for a hydropower plant in an Alpine hydropower regulated catchment - coupling of operational and hydrological forecasts

    Science.gov (United States)

    Tilg, Anna-Maria; Schöber, Johannes; Huttenlau, Matthias; Messner, Jakob; Achleitner, Stefan

    2017-04-01

    Hydropower is a renewable energy source which can help to stabilize fluctuations in the volatile energy market. Especially pumped-storage infrastructures in the European Alps play an important role within the European energy grid system. Today, the runoff of rivers in the Alps is often influenced by cascades of hydropower infrastructures where the operational procedures are triggered by energy market demands, water deliveries and flood control aspects rather than by hydro-meteorological variables. An example for such a highly hydropower regulated river is the catchment of the river Inn in the Eastern European Alps, originating in the Engadin (Switzerland). A new hydropower plant is going to be built as transboundary project at the boarder of Switzerland and Austria using the water of the Inn River. For the operation, a runoff forecast to the plant is required. The challenge in this case is that a high proportion of runoff is turbine water from an upstream situated hydropower cascade. The newly developed physically based hydrological forecasting system is mainly capable to cover natural hydrological runoff processes caused by storms and snow melt but can model only a small degree of human impact. These discontinuous parts of the runoff downstream of the pumped storage are described by means of an additional statistical model which has been developed. The main goal of the statistical model is to forecast the turbine water up to five days in advance. The lead time of the data driven model exceeds the lead time of the used energy production forecast. Additionally, the amount of turbine water is linked to the need of electricity production and the electricity price. It has been shown that especially the parameters day-ahead prognosis of the energy production and turbine inflow of the previous week are good predictors and are therefore used as input parameters for the model. As the data is restricted due to technical conditions, so-called Tobit models have been used to

  2. 50 CFR 648.8 - Vessel identification.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Vessel identification. 648.8 Section 648.8... identification. (a) Vessel name and official number. Each fishing vessel subject to this part and over 25 ft (7.6... or ocean quahog vessels licensed under New Jersey law may use the appropriate vessel identification...

  3. Evaluation of Data-Logging Transducer to Passively Collect Pressure Vessel p/T History

    Science.gov (United States)

    Wnuk, Stephen P.; Le, Son; Loew, Raymond A.

    2013-01-01

    Pressure vessels owned and operated by NASA are required to be regularly certified per agency policy. Certification requires an assessment of damage mechanisms and an estimation of vessel remaining life. Since detail service histories are not typically available for most pressure vessels, a conservative estimate of vessel pressure/temperature excursions is typically used in assessing fatigue life. This paper details trial use of a data-logging transducer to passively obtain actual pressure and temperature service histories of pressure vessels. The approach was found to have some potential for cost savings and other benefits in certain cases.

  4. Internal Controls and Compliance With Laws and Regulations for the Defense Business Operations Fund Consolidated Financial Statements for FY 1995

    National Research Council Canada - National Science Library

    Lane, Frederick

    1996-01-01

    The objective of the audit was to determine whether the Consolidated Statement of Financial Position and selected accounts on the Statement of Operations of the Defense Business Operations Fund for FY...

  5. Productivity of the Regional Bell Operating Companies Under Rate-of-Return and Price-Cap Regulation

    OpenAIRE

    Kelly, Tracey Elizabeth

    1997-01-01

    In 1991, the Federal Communications Commission began regulating the tariffed rates of the nation's largest local exchange carriers under a new regulatory scheme: price-cap regulation. Price caps were intended to "remedy" the ills of traditional rate-of-return regulation. They were to provide incentive for the telephone companies to adopt innovative technology, cost-cutting measures and provide telephone services more efficiently. To test the effectiveness of this incentive, this study exami...

  6. 2D Fast Vessel Visualization Using a Vessel Wall Mask Guiding Fine Vessel Detection

    Directory of Open Access Journals (Sweden)

    Sotirios Raptis

    2010-01-01

    and then try to approach the ridges and branches of the vasculature's using fine detection. Fine vessel screening looks into local structural inconsistencies in vessels properties, into noise, or into not expected intensity variations observed inside pre-known vessel-body areas. The vessels are first modelled sufficiently but not precisely by their walls with a tubular model-structure that is the result of an initial segmentation. This provides a chart of likely Vessel Wall Pixels (VWPs yielding a form of a likelihood vessel map mainly based on gradient filter's intensity and spatial arrangement parameters (e.g., linear consistency. Specific vessel parameters (centerline, width, location, fall-away rate, main orientation are post-computed by convolving the image with a set of pre-tuned spatial filters called Matched Filters (MFs. These are easily computed as Gaussian-like 2D forms that use a limited range sub-optimal parameters adjusted to the dominant vessel characteristics obtained by Spatial Grey Level Difference statistics limiting the range of search into vessel widths of 16, 32, and 64 pixels. Sparse pixels are effectively eliminated by applying a limited range Hough Transform (HT or region growing. Major benefits are limiting the range of parameters, reducing the search-space for post-convolution to only masked regions, representing almost 2% of the 2D volume, good speed versus accuracy/time trade-off. Results show the potentials of our approach in terms of time for detection ROC analysis and accuracy of vessel pixel (VP detection.

  7. BY FRUSTUM CONFINING VESSEL

    Directory of Open Access Journals (Sweden)

    Javad Khazaei

    2016-09-01

    Full Text Available Helical piles are environmentally friendly and economical deep foundations that, due to environmental considerations, are excellent additions to a variety of deep foundation alternatives available to the practitioner. Helical piles performance depends on soil properties, the pile geometry and soil-pile interaction. Helical piles can be a proper alternative in sensitive environmental sites if their bearing capacity is sufficient to support applied loads. The failure capacity of helical piles in this study was measured via an experimental research program that was carried out by Frustum Confining Vessel (FCV. FCV is a frustum chamber by approximately linear increase in vertical and lateral stresses along depth from top to bottom. Due to special geometry and applied bottom pressure, this apparatus is a proper choice to test small model piles which can simulate field stress conditions. Small scale helical piles are made with either single helix or more helixes and installed in fine grained sand with three various densities. Axial loading tests including compression and tension tests were performed to achieve pile ultimate capacity. The results indicate the helical piles behavior depends essentially on pile geometric characteristics, i.e. helix configuration and soil properties. According to the achievements, axial uplift capacity of helical model piles is about equal to usual steel model piles that have the helixes diameter. Helical pile compression bearing capacity is too sufficient to act as a medium pile, thus it can be substituted other piles in special geoenvironmental conditions. The bearing capacity also depends on spacing ratio, S/D, and helixes diameter.

  8. Confinement Vessel Assay System: Design and Implementation Report

    Energy Technology Data Exchange (ETDEWEB)

    Frame, Katherine C. [Los Alamos National Laboratory; Bourne, Mark M. [Los Alamos National Laboratory; Crooks, William J. [Los Alamos National Laboratory; Evans, Louise [Los Alamos National Laboratory; Mayo, Douglas R. [Los Alamos National Laboratory; Gomez, Cipriano D. [Retired CMR-OPS: OPERATIONS; Miko, David K. [Los Alamos National Laboratory; Salazar, William R. [Los Alamos National Laboratory; Stange, Sy [Los Alamos National Laboratory; Vigil, Georgiana M. [Los Alamos National Laboratory

    2012-07-18

    Los Alamos National Laboratory has a number of spherical confinement vessels remaining from tests involving nuclear materials. These vessels have an inner diameter of 6 feet with 1- to 2-inch thick steel walls. The goal of the Confinement Vessel Disposition (CVD) project is to remove debris and reduce contamination inside the vessels. We have developed a neutron assay system for the purposes of Materials Control and Accountability (MC&A) measurements of the vessel prior to and after cleanout. We present our approach to confronting the challenges in designing, building, and testing such a system. The system was designed to meet a set of functional and operational requirements. A Monte Carlo model was developed to aid in optimizing the detector design as well as to predict the systematic uncertainty associated with confinement vessel measurements. Initial testing was performed to optimize and determine various measurement parameters, and then the system was characterized using {sup 252}Cf placed a various locations throughout the measurement system. Measurements were also performed with a {sup 252}Cf source placed inside of small steel and HDPE shells to study the effect of moderation. These measurements compare favorably with their MCNPX model equivalent, making us confident that we can rely on the Monte Carlo simulation to predict the systematic uncertainty due to variations in response to material that may be localized at different points within a vessel.

  9. [Morphogenesis, structure and properties of lymphatic vessels].

    Science.gov (United States)

    Ratajska, Anna; Jankowska-Steifer, Ewa; Czarnowska, Elżbieta; Flaht, Aleksandra; Radomska-Leśniewska, Dorota

    2012-11-19

    In this paper, we present literature results related to structure and various manners of lymphatic vessel formation during embryonic development and in pathological events, such as tumorigenesis, wound healing, and other diseases. The functions of the lymphatic system include the collection of fluids that enter tissues from the circulation, absorption of lipids and lipid-soluble vitamins from the intestine and their subsequent transport, participation in antigen, dendritic cell, and lymphocyte migration. The lymphatic system is also a route for tumor cell and inflammatory cell transport. Native lymphatic capillaries differ from blood capillaries by having an irregular lumen, a discontinuous basement membrane, absence of pericytes, and a strong anchorage of their endothelial cells to the extracellular matrix via microfibrils built of emilin and fibrillin. Lymphatic endothelial cells express surface antigens such as Lyve-1, podoplanin, VEGFR3 (Flk4) and transcription factor Prox-1, as well as molecules which are common for blood endothelial cells and lymphatic endothelial cells (CD31, CD34, Flk-1, Tie-1, Tie-2, neuropilin 2). Lymphatic vessel formation during embryonic development starts with the occurrence of lymphatic sacs sprouting from systemic jugular veins and/or by co-option of lymphangioblasts or hematopoietic-derived cells. It can also proceed by dedifferentiation of venous endothelial cells after their detachment from the venous system, migration to the target places within the body and assembly in the lymphatic lumen. Mechanisms of lymphatic vessel formation during embryonic development and in pathological conditions, such as tumorigenesis, wound healing, and metastasis, is regulated by a plethora of growth factors and molecules, among which the most important are VEGF-C, VEGF-D, HGF, FGF, retinoic acid, IL-3, and IL-7. Macrophages and cells bearing CD45 phenotype seem to take part in the formation of lymphatics. Macrophages might act as a source of growth

  10. 76 FR 42545 - Regulated Navigation Area; Chelsea Street Bridge Construction, Chelsea, MA

    Science.gov (United States)

    2011-07-19

    ...The United States Coast Guard is establishing a regulated navigation area (RNA) on the navigable waters of the Chelsea River under and surrounding the Chelsea Street Bridge (CSB) that crosses the Chelsea River between East Boston and Chelsea, Massachusetts. This temporary interim rule allows the Coast Guard to suspend all vessel traffic within the RNA for construction operations, both planned and unforeseen, that could pose an imminent hazard to vessels operating in the area. This rule is necessary to provide for the safety of life on the navigable waters during the construction of the Chelsea Street Bridge.

  11. 76 FR 57910 - Regulated Navigation Area; Route 24 Bridge Construction, Tiverton and Portsmouth, RI

    Science.gov (United States)

    2011-09-19

    ...The Coast Guard is establishing a regulated navigation area (RNA) on the navigable waters of the Sakonnet River under and surrounding construction of the new Route 24 bridge that crosses the Sakonnet River between Tiverton and Portsmouth, Rhode Island. This rule implements certain safety measures including establishment of a temporary channel beneath the bridge, speed restrictions, and suspension of all vessel traffic within the RNA during construction operations that could pose an imminent hazard to vessels operating in the area. This rule is necessary to provide for the safety of life on the navigable waters during construction of the Route 24 bridge over the main channel of the Sakonnet River.

  12. Development of a new fluorescent reporter:operator system: location of AraC regulated genes in Escherichia coli K-12.

    Science.gov (United States)

    Sellars, Laura E; Bryant, Jack A; Sánchez-Romero, María-Antonia; Sánchez-Morán, Eugenio; Busby, Stephen J W; Lee, David J

    2017-08-03

    In bacteria, many transcription activator and repressor proteins regulate multiple transcription units that are often distally distributed on the bacterial genome. To investigate the subcellular location of DNA bound proteins in the folded bacterial nucleoid, fluorescent reporters have been developed which can be targeted to specific DNA operator sites. Such Fluorescent Reporter-Operator System (FROS) probes consist of a fluorescent protein fused to a DNA binding protein, which binds to an array of DNA operator sites located within the genome. Here we have developed a new FROS probe using the Escherichia coli MalI transcription factor, fused to mCherry fluorescent protein. We have used this in combination with a LacI repressor::GFP protein based FROS probe to assess the cellular location of commonly regulated transcription units that are distal on the Escherichia coli genome. We developed a new DNA binding fluorescent reporter, consisting of the Escherichia coli MalI protein fused to the mCherry fluorescent protein. This was used in combination with a Lac repressor:green fluorescent protein fusion to examine the spatial positioning and possible co-localisation of target genes, regulated by the Escherichia coli AraC protein. We report that induction of gene expression with arabinose does not result in co-localisation of AraC-regulated transcription units. However, measurable repositioning was observed when gene expression was induced at the AraC-regulated promoter controlling expression of the araFGH genes, located close to the DNA replication terminus on the chromosome. Moreover, in dividing cells, arabinose-induced expression at the araFGH locus enhanced chromosome segregation after replication. Regions of the chromosome regulated by AraC do not colocalise, but transcription events can induce movement of chromosome loci in bacteria and our observations suggest a role for gene expression in chromosome segregation.

  13. Nuclear reactor pressure vessel support system

    Science.gov (United States)

    Sepelak, George R.

    1978-01-01

    A support system for nuclear reactor pressure vessels which can withstand all possible combinations of stresses caused by a postulated core disrupting accident during reactor operation. The nuclear reactor pressure vessel is provided with a flange around the upper periphery thereof, and the flange includes an annular vertical extension formed integral therewith. A support ring is positioned atop of the support ledge and the flange vertical extension, and is bolted to both members. The plug riser is secured to the flange vertical extension and to the top of a radially outwardly extension of the rotatable plug. This system eliminates one joint through which fluids contained in the vessel could escape by making the fluid flow path through the joint between the flange and the support ring follow the same path through which fluid could escape through the plug risers. In this manner, the sealing means to prohibit the escape of contained fluids through the plug risers can also prohibit the escape of contained fluid through the securing joint.

  14. Maritime Training Serbian Autonomous Vessel Protection Detachment

    Directory of Open Access Journals (Sweden)

    Šoškić Svetislav D.

    2014-06-01

    Full Text Available The crisis in Somalia has caused appearance of piracy at sea in the Gulf of Aden and the Western Indian Ocean. Somali pirates have become a threat to economic security of the world because almost 30 percent of world oil and 20 percent of global trade passes through the Gulf of Aden. Solving the problem of piracy in this part of the world have included international organizations, institutions, military alliances and the states, acting in accordance with international law and UN Security Council resolutions. The European Union will demonstrate the application of a comprehensive approach to solving the problem of piracy at sea and the crisis in Somalia conducting naval operation — EU NAVFOR Atalanta and operation EUTM under the Common Security and Defense Policy. The paper discusses approaches to solving the problem of piracy in the Gulf of Aden and the crisis in Somalia. Also, the paper points to the complexity of the crisis in Somalia and dilemmas correctness principles that are applied to solve the problem piracy at sea. One of goals is protections of vessels of the World Food Programme (WFP delivering food aid to displaced persons in Somalia. Republic of Serbia joined in this mission and trained and sent one a autonomous team in this military operation for protection WFP. This paper consist the problem of modern piracy, particularly in the area of the Horn of Africa became a real threat for the safety of maritime ships and educational process of Serbian Autonomous vessel protection detachment. Serbian Military Academy adopted and developed educational a training program against piracy applying all the provisions and recommendations of the IMO conventions and IMO model courses for Serbian Autonomous vessel protection detachment.

  15. 2013 East Coast Vessel Tracklines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  16. SC/OQ Vessel Database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data tables holding information for the Surf Clam/Ocean Quahog vessel and dealer/processor logbooks (negative and positive), as well as individual tag information...

  17. 2011 Great Lakes Vessel Tracklines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  18. 2011 West Coast Vessel Tracklines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  19. 2013 Great Lakes Vessel Tracklines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  20. 2011 East Coast Vessel Tracklines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  1. Integrin binding: Sticking around vessels

    Science.gov (United States)

    Blatchley, Michael R.; Gerecht, Sharon

    2017-09-01

    A study demonstrates that controlled integrin binding on a biomaterial was capable of promoting vascular cell sprouting and formation of a non-leaky blood vessel network in a healthy and diseased state.

  2. Transposition of the great vessels

    Science.gov (United States)

    ... vessel called the ductus arteriosus open, allowing some mixing of the 2 blood circulations. A procedure using ... they are not already immune. Eating well, avoiding alcohol, and controlling diabetes both before and during pregnancy ...

  3. 2013 West Coast Vessel Tracklines

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  4. 2011 Tug Towing Vessel Density

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Automatic Identification Systems (AIS) are a navigation safety device that transmits and monitors the location and characteristics of many vessels in U.S. and...

  5. Caribbean PR Logbook Survey (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains catch (landed catch) and effort for fishing trips made by vessels fishing in Puerto Rico. The catch and effort data for the entire trip are...

  6. Coastal Discard Logbook Survey (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains data on the type and amount of marine resources that are discarded or interacted with by vessels that are selected to report to the Southeast...

  7. 47 CFR 3.53 - FCC notification of refusal to provide telecommunications service to U.S. registered vessel(s).

    Science.gov (United States)

    2010-10-01

    ... COMMISSION GENERAL AUTHORIZATION AND ADMINISTRATION OF ACCOUNTING AUTHORITIES IN MARITIME AND MARITIME MOBILE-SATELLITE RADIO SERVICES Settlement Operations § 3.53 FCC notification of refusal to provide telecommunications service to U.S. registered vessel(s). An accounting authority must inform the FCC immediately...

  8. LQG Dynamic Positioning for a Supply Vessel

    Science.gov (United States)

    Hansen, Scott Ron

    The purpose of this study is to merge my on the job marine experience and the control knowledge gathered throughout my studies at University of California San Diego into a practical control design. This thesis creates a Dynamic Positioning (DP) control loop for a supply vessel which utilizes two azimuthal thrusters as actuators. The control loop is designed to also account for external environmental disturbances and sensor measurement noise. The control loop is accomplished using modern control theory which makes use of known vessel dynamics and assumptions associated with the environment and sensor measurement variances. During this thesis research and design period, a testing platform for the control loop was required. Without the ability to retrofit a physical vessel with the proposed azimuthal thrusters it was determined that a simulation model would be required and was designed and implemented in Matlab Simulink to allow for control loop testing and validation. This simulation model is presented as part of the thesis research and design flow as it was a required element of the design and encompasses the knowledge acquired in my marine work and during my period at UCSD. Control loop performance results were obtained through testing on the generated simulation model. These results allowed for validation and optimization during the design phases of the vessel control loop. The principal conclusions were that the simulation model provided sufficient dynamics to properly execute the required tests to the control loop and that the implemented control loop was capable of operating within the determined parameters set forth in the design validation testing.

  9. Prosopomorphic vessels from Moesia Superior

    Directory of Open Access Journals (Sweden)

    Nikolić Snežana

    2008-01-01

    Full Text Available The prosopomorphic vessels from Moesia Superior had the form of beakers varying in outline but similar in size. They were wheel-thrown, mould-made or manufactured by using a combination of wheel-throwing and mould-made appliqués. Given that face vessels are considerably scarcer than other kinds of pottery, more than fifty finds from Moesia Superior make an enviable collection. In this and other provinces face vessels have been recovered from military camps, civilian settlements and necropolises, which suggests that they served more than one purpose. It is generally accepted that the faces-masks gave a protective role to the vessels, be it to protect the deceased or the family, their house and possessions. More than forty of all known finds from Moesia Superior come from Viminacium, a half of that number from necropolises. Although tangible evidence is lacking, there must have been several local workshops producing face vessels. The number and technological characteristics of the discovered vessels suggest that one of the workshops is likely to have been at Viminacium, an important pottery-making centre in the second and third centuries.

  10. WRKY54 and WRKY70 co-operate as negative regulators of leaf senescence in Arabidopsis thaliana

    OpenAIRE

    Besseau, Sébastien; Li, Jing; Palva, E. Tapio

    2012-01-01

    The plant-specific WRKY transcription factor (TF) family with 74 members in Arabidopsis thaliana appears to be involved in the regulation of various physiological processes including plant defence and senescence. WRKY53 and WRKY70 were previously implicated as positive and negative regulators of senescence, respectively. Here the putative function of other WRKY group III proteins in Arabidopsis leaf senescence has been explored and the results suggest the involvement of two additional WRKY TF...

  11. 77 FR 54808 - Vessels in Foreign and Domestic Trades

    Science.gov (United States)

    2012-09-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Customs and Border Protection 19 CFR Part 4 Vessels in Foreign and Domestic Trades CFR Correction In Title 19 of the Code of Federal Regulations, Parts 1 to 99, revised as of April 1, 2012, on page...

  12. Green Arctic Patrol Vessel

    Science.gov (United States)

    2011-08-01

    C shows the expected 2030 air temperature, ocean ice, sea state, wind, precipitation, illumination , icing and ceiling for each GAPV operating area...100 to 3,000 feet) • Medium (3,000 to 10,000 feet) • High (>10,000 feet) Illumination • Precipitation Rate Icing3 • Standard • Day • Low...dusk, dawn, moonlit, streetlight lit) • Night • Heavy (>0.3"/hr) • Moderate (0.1-0.3"/hr) • Light (trace-ɘ.1"/hr) • Trace (does not

  13. Anchor handling tug operations: a practical guide to the operation of modern anchor handling tugs engaged in anchor handling and towing operations

    National Research Council Canada - National Science Library

    Clark, I.C; Hancox, M

    2012-01-01

    ... --Turning and manoeuvring modern anchor handling vessels --The AHTS design and towing operations --The dangers of very high speed loads during deep water anchor handling operations --The dangers...

  14. Evolutionary algorithm for automatic detection of blood vessel shapes

    Science.gov (United States)

    Kutics, Andrea

    1996-04-01

    Automatic detection of blood vessel shapes locating in the skin has a great diagnostic importance. In this work, an evolutionary approach operating on morphological operator and operation structures is proposed for the determination of the shape and network of blood vessels located in upper skin layers. A population of individuals comprising morphological structures is generated. A two-dimensional queue like data representation of individuals is applied in order to provide an appropriate representation of the connectivity constraints originated in the two dimensional nature of the structuring elements. Two-dimensional crossover and mutation type manipulation operations are carried out on selected elements of the population. Unlike the usual techniques, in our approach no constraints are used for background and smoothness as no matched filter or linear operator is applied. Also no a priori knowledge of the vessel shape is necessary due to the evolutionary method. Unlike the usual imaging techniques, that mainly use angiograms as input, in this work infrared filtered images taken by CCD camera are applied to investigate the blood vessels of broad skin areas. The method is implemented parallel on a lattice network of transputers resulting in a significantly decreased processing time compared to the usual techniques.

  15. Automated method for identification and artery-venous classification of vessel trees in retinal vessel networks.

    Directory of Open Access Journals (Sweden)

    Vinayak S Joshi

    Full Text Available The separation of the retinal vessel network into distinct arterial and venous vessel trees is of high interest. We propose an automated method for identification and separation of retinal vessel trees in a retinal color image by converting a vessel segmentation image into a vessel segment map and identifying the individual vessel trees by graph search. Orientation, width, and intensity of each vessel segment are utilized to find the optimal graph of vessel segments. The separated vessel trees are labeled as primary vessel or branches. We utilize the separated vessel trees for arterial-venous (AV classification, based on the color properties of the vessels in each tree graph. We applied our approach to a dataset of 50 fundus images from 50 subjects. The proposed method resulted in an accuracy of 91.44% correctly classified vessel pixels as either artery or vein. The accuracy of correctly classified major vessel segments was 96.42%.

  16. 78 FR 40436 - Proposed Information Collection; Comment Request; Mandatory Shrimp Vessel and Gear...

    Science.gov (United States)

    2013-07-05

    ... Shrimp Vessel and Gear Characterization Survey AGENCY: National Oceanic and Atmospheric Administration... Shrimp Fishery Management Plan (FMP). The regulations for the Gulf Shrimp Vessel and Gear... Gear Characterization Form. The form will be provided by NMFS at the time of permit application and...

  17. 50 CFR 697.8 - Vessel identification.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Vessel identification. 697.8 Section 697.8 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION....8 Vessel identification. (a) Vessel name and official number. Each fishing vessel issued a limited...

  18. Structural integrity of nuclear reactor pressure vessels

    Science.gov (United States)

    Knott, John F.

    2013-09-01

    The paper starts from concerns expressed by Sir Alan Cottrell, in the early 1970s, related to the safety of the pressurized water reactor (PWR) proposed at that time for the next phase of electrical power generation. It proceeds to describe the design and operation of nuclear generation plant and gives details of the manufacture of PWR reactor pressure vessels (RPVs). Attention is paid to stress-relief cracking and under-clad cracking, experienced with early RPVs, explaining the mechanisms for these forms of cracking and the means taken to avoid them. Particular note is made of the contribution of non-destructive inspection to structural integrity. Factors affecting brittle fracture in RPV steels are described: in particular, effects of neutron irradiation. The use of fracture mechanics to assess defect tolerance is explained, together with the failure assessment diagram embodied in the R6 procedure. There is discussion of the Master Curve and how it incorporates effects of irradiation on fracture toughness. Dangers associated with extrapolation of data to low probabilities are illustrated. The treatment of fatigue-crack growth is described, in the context of transients that may be experienced in the operation of PWR plant. Detailed attention is paid to the thermal shock associated with a large loss-of-coolant accident. The final section reviews the arguments advanced to justify 'Incredibility of Failure' and how these are incorporated in assessments of the integrity of existing plant and proposed 'new build' PWR pressure vessels.

  19. The integrated approach—Regulating private human spaceflight as space activity, aircraft operation, and high-risk adventure tourism

    Science.gov (United States)

    von der Dunk, Frans G.

    2013-12-01

    One of the overriding issues concerning private human spaceflight concerns how to properly regulate this specific new type of activity. Noting that in the discussion regarding regulation thereof usually the three distinct regimes of space law, air law and high-risk adventure tourism law are drawn upon to look for solutions, the present paper addresses the key elements of each of these approaches as they are to some extent already currently being applied and where, as a consequence, gaps and overlaps arise, as well as presents an effort to address the latter in a sensible, coherent, efficient and feasible manner.

  20. [Polyurethane vessels for microvascular surgical training to reduce animal use].

    Science.gov (United States)

    Meier, Sonja A; Lang, Axel; Beer, Gertrude M

    2004-01-01

    Systematic training of the manual skills is inevitable in learning microsurgery. Generally, first exercises are done on two-dimensional models, then the training continues on animals. With the growing ethical awareness, the obligation to protect animals and the stricter animal protection laws, realistic three-dimensional models have become necessary for training of microsurgery. However, the available alternatives all have certain disadvantages. We tested vessels made of polyurethane for microvascular surgical training and compared them to the available three-dimensional synthetic alternatives. Rose-coloured (arteries) or blue (veins), opaque vessels with a minimal wall thickness of 0.12 mm and a minimal internal diameter of 1 mm are used. To mimic the surgical access and the depth of the operative field, the vessels can be embedded in a synthetic box with or without a cap. The completed anastomosis is checked by injection of a coloured fluid. The consistency and the variable relation of the thickness of the wall to the internal diameter very closely reflect the biological situation. Even training on very fragile venous walls is possible in all manners. After completion of anastomosis the vessels can be opened longitudinally to check the patency of the anastomotic site. The described polyurethane vessels are very suitable for microsurgical training as a useful step between the two-dimensional model and the animal. The number of animals required for microsurgical training can clearly be reduced by the use of such synthetic polyurethane vessels.

  1. Results of NanTroSEIZE Expeditions Stages 1 & 2: Deep-sea Coring Operations on-board the Deep-sea Drilling Vessel Chikyu and Development of Coring Equipment for Stage 3

    Science.gov (United States)

    Shinmoto, Y.; Wada, K.; Miyazaki, E.; Sanada, Y.; Sawada, I.; Yamao, M.

    2010-12-01

    The Nankai-Trough Seismogenic Zone Experiment (NanTroSEIZE) has carried out several drilling expeditions in the Kumano Basin off the Kii-Peninsula of Japan with the deep-sea scientific drilling vessel Chikyu. Core sampling runs were carried out during the expeditions using an advanced multiple wireline coring system which can continuously core into sections of undersea formations. The core recovery rate with the Rotary Core Barrel (RCB) system was rather low as compared with other methods such as the Hydraulic Piston Coring System (HPCS) and Extended Shoe Coring System (ESCS). Drilling conditions such as hole collapse and sea conditions such as high ship-heave motions need to be analyzed along with differences in lithology, formation hardness, water depth and coring depth in order to develop coring tools, such as the core barrel or core bit, that will yield the highest core recovery and quality. The core bit is especially important in good recovery of high quality cores, however, the PDC cutters were severely damaged during the NanTroSEIZE Stages 1 & 2 expeditions due to severe drilling conditions. In the Stage 1 (riserless coring) the average core recovery was rather low at 38 % with the RCB and many difficulties such as borehole collapse, stick-slip and stuck pipe occurred, causing the damage of several of the PDC cutters. In Stage 2, a new design for the core bit was deployed and core recovery was improved at 67 % for the riserless system and 85 % with the riser. However, due to harsh drilling conditions, the PDC core bit and all of the PDC cutters were completely worn down. Another original core bit was also deployed, however, core recovery performance was low even for plate boundary core samples. This study aims to identify the influence of the RCB system specifically on the recovery rates at each of the holes drilled in the NanTroSEIZE coring expeditions. The drilling parameters such as weight-on-bit, torque, rotary speed and flow rate, etc., were analyzed

  2. 19 CFR 4.5 - Government vessels.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Government vessels. 4.5 Section 4.5 Customs Duties... VESSELS IN FOREIGN AND DOMESTIC TRADES Arrival and Entry of Vessels § 4.5 Government vessels. (a) No... that is the property of, the U.S. Department of Defense (DoD) will be treated as a Government vessel...

  3. [Pulmonary blood vessels in goats].

    Science.gov (United States)

    Roos, H; Hegner, K; Vollmerhaus, B

    1999-05-01

    The blood vessels in the lung of the goat, which until now have received little attention, are described in detail for the first time. With regard to the segments of the lung, blood vessels are bronchovascular units in the lobi craniales, lobus medius and lobus accessorius, but bronchoartery units in the lobi caudales. We investigated the types of branches of the Aa. pulmonales dextra et sinistra, the inter- and intraspecific principles of the outlet of the pulmonary veins and the importance of bronchopulmonary segmentation of the lungs.

  4. Influence of the acetolactate synthase inhibitor metsulfuron-methyl on the operation, regulation and organisation of photosynthesis in Solanum nigrum

    NARCIS (Netherlands)

    Riethmuller-Haage, I.C.P.; Bastiaans, L.; Harbinson, J.; Kempenaar, C.; Kropff, M.J.

    2006-01-01

    The influence of the acetolactate synthase inhibitor metsulfuron-methyl on the operation of the photosynthetic apparatus was examined on 4-weeks-old climate chamber-grown Solanum nigrum plant. To have an indication on the relative performance of the photosynthetic apparatus of ALS-treated plants,

  5. A Candida albicans regulator of disseminated infection operates primarily as a repressor and governs cell surface remodeling.

    Science.gov (United States)

    Böhm, Lena; Muralidhara, Prathibha; Pérez, J Christian

    2016-04-01

    Virulence traits are often controlled by transcription regulators, i.e. sequence-specific DNA-binding proteins. The regulators that sustain microbial proliferation in the host typically work by promoting the expression of the genes that mediate such traits. Here, we report a singular example in the human fungal pathogen Candida albicans in which a transcription regulator functions by repressing the expression of virulence genes, yet its overall role is to promote virulence. We explain this apparent paradox by establishing that a major function of this protein, Zcf21p, is to set a default state of low expression of multiple cell wall components which include virulence determinants. These components comprise GPI-anchored proteins, adhesins and enzymes that synthesize cell wall sugar decorations. Deletion or overexpression of ZCF21 results in cell wall structure modifications that influence recognition and elimination of the fungus by macrophages. By leveling off the expression of adhesins, ZCF21 also prevents C. albicans self-aggregation. Balancing the expression of cell wall components - virulence determinants included - is, therefore, critical for C. albicans to assemble a cell surface configuration that is suitable to colonize mammalian tissues and evade immune surveillance. © 2015 John Wiley & Sons Ltd.

  6. 33 CFR 104.297 - Additional requirements-vessels on international voyages.

    Science.gov (United States)

    2010-07-01

    .... flag vessel, which is subject to the International Convention for Safety of Life at Sea, 1974, (SOLAS), must be in compliance with the applicable requirements of SOLAS Chapter XI-1, SOLAS Chapter XI-2 and... operators of U.S. flag vessels that are required to comply with SOLAS, must ensure an International Ship...

  7. Multipurpose service vessels. Versatile toolkits for well intervention

    Energy Technology Data Exchange (ETDEWEB)

    Adamson, S. [Dowell, Las Morochas (Venezuela); Cupello, F.; Hicks, J.; Keenleyside, M. [Sedco Forex, Las Morochas (Venezuela); Formas, D.; Gabillard, C. [Sedco Forex, Montrouge (France); Gamarra, F.; Sanchez, A. [Lagoven SA, Tia Juana (Venezuela)

    1996-12-31

    The industry has entered a new area in offshore support operations. Today, novel concepts and designs offer an expanded range of capabilities from a single vessel rather than the multiple boats and barges that have been used in the past. This continuing evolution in marine services is rapidly transforming well workover and intervention activities, and solving logistics and performance problems that have challenged oil and gas operators for decades. 13 figs., 5 refs.

  8. Young capillary vessels rejuvenate aged pancreatic islets

    Science.gov (United States)

    Almaça, Joana; Molina, Judith; Arrojo e Drigo, Rafael; Abdulreda, Midhat H.; Jeon, Won Bae; Berggren, Per-Olof; Caicedo, Alejandro; Nam, Hong Gil

    2014-01-01

    Pancreatic islets secrete hormones that play a key role in regulating blood glucose levels (glycemia). Age-dependent impairment of islet function and concomitant dysregulation of glycemia are major health threats in aged populations. However, the major causes of the age-dependent decline of islet function are still disputed. Here we demonstrate that aging of pancreatic islets in mice and humans is notably associated with inflammation and fibrosis of islet blood vessels but does not affect glucose sensing and the insulin secretory capacity of islet beta cells. Accordingly, when transplanted into the anterior chamber of the eye of young mice with diabetes, islets from old mice are revascularized with healthy blood vessels, show strong islet cell proliferation, and fully restore control of glycemia. Our results indicate that beta cell function does not decline with age and suggest that islet function is threatened by an age-dependent impairment of islet vascular function. Strategies to mitigate age-dependent dysregulation in glycemia should therefore target systemic and/or local inflammation and fibrosis of the aged islet vasculature. PMID:25404292

  9. Analisa Greenwater Akibat Gerakan Offshore Security Vessel

    Directory of Open Access Journals (Sweden)

    Maulidya Octaviani Bustamin

    2012-09-01

    Full Text Available Analisa  Tugas  Akhir  ini,  terdiri  atas  beberapa  tahapan.  Yang pertama yaitu perancangan struktur Offshore Security Vessel (OSV dengan bantuan software MAXSURF guna mendapatkan Lines Plan. Offset data yang diperoleh digunakan dalam pemodelan menggunakan MOSES,  kemudian  dilakukan  analisa  gerak  OSV  dalam  gelombang  regular  dan dinyatakan dalam grafik RAO. Analisa gerak relatif vertikal  haluan dihitung dari RAO gerakan, dan kemudian melakukan evaluasi perilaku di gelombang acak dengan analisis spektra gelombang. Dari analisa spektra didapatkan parameter greenwater sehingga dapat dihitung peluang, intensitas dan tekanan greenwater. Dari hasil analisa diperoleh RAO gerak vertikal Offshore Security Vessel (OSV pada  gelombang  reguler yang dipengaruhi  oleh  kecepatan,  kondisi  muatan  dan arah gelombang. Peluang terjadinya greenwater terbesar terjadi pada sudut datang gelombang following sea (0o dimana harga terbesar terjadi pada ω = 0.2 rad/sec dengan periode 29 detik mencapai 0.477. Intensitas greenwater terbesar terjadi pada saat sudut datang gelombang following sea (0o adalah sebanyak 59.265 per jam dan 0.378 per detik. Tekanan greenwater terbesar terjadi pada saat sudut datang gelombang head sea (180o sebesar 1678x10-6 MPa. Dengan nilai tersebut, deck mampu menahan beban akibat tekanan greenwater.

  10. Estimation Of Blood Vessels Functional State By Means Of Analysis Of Temperature Reaction On Occlusive Test

    Directory of Open Access Journals (Sweden)

    A.P. Rytik

    2009-12-01

    Full Text Available Temperature reaction of distant phalanges in the case of the occlusive test has been registered. It has been revealed that the temperature reaction on the occlusive test for the group of patients with disturbances of vessel tone regulation differs from the reaction of norm group. Possible influence of vessel regulation state and volumetric blood supply on the skin temperature dynamics has been estimated. Diagnostic ability of the temperature occlusive test has been investigated

  11. Commercial Passenger Fishing Vessel Fishery

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains the logbook data from U.S.A. Commercial Passenger Fishing Vessels (CPFV) fishing in the U.S.A. EEZ and in waters off of Baja California, from...

  12. Pressure vessel and method therefor

    Energy Technology Data Exchange (ETDEWEB)

    Saunders, Timothy

    2017-09-05

    A pressure vessel includes a pump having a passage that extends between an inlet and an outlet. A duct at the pump outlet includes at least one dimension that is adjustable to facilitate forming a dynamic seal that limits backflow of gas through the passage.

  13. BPC 157 and blood vessels.

    Science.gov (United States)

    Seiwerth, Sven; Brcic, Luka; Vuletic, Lovorka Batelja; Kolenc, Danijela; Aralica, Gorana; Misic, Marija; Zenko, Anita; Drmic, Domagoj; Rucman, Rudolf; Sikiric, Predrag

    2014-01-01

    This review focuses on the described effects of BPC 157 on blood vessels after different types of damage, and elucidate by investigating different aspects of vascular response to injury (endothelium damage, clotting, thrombosis, vasoconstriction, vasodilatation, vasculoneogenesis and edema formation) especially in connection to the healing processes. In this respect, BPC 157 was concluded to be the most potent angiomodulatory agent, acting through different vasoactive pathways and systems (e.g. NO, VEGF, FAK) and leading to optimization of the vascular response followed, as it has to be expected, by optimization of the healing process. Formation of new blood vessels involves two main, partly overlapping mechanisms, angiogenesis and vasculogenesis. The additional mechanism of arteriogenesis is involved in the formation of collaterals. In conjunction with blood vessel function, we at least have to consider leakage of fluid/proteins/plasma, resulting in edema/exudate formation as well as thrombogenesis. Blood vessels are also strongly involved in tumor biology. In this aspect, we have neoangiogenesis resulting in pathological vascularization, vascular invasion resulting in release of metastatic cells and the phenomenon of homing resulting in formation of secondary tumors--metastases.

  14. The determinants of fishing vessel accident severity.

    Science.gov (United States)

    Jin, Di

    2014-05-01

    The study examines the determinants of fishing vessel accident severity in the Northeastern United States using vessel accident data from the U.S. Coast Guard for 2001-2008. Vessel damage and crew injury severity equations were estimated separately utilizing the ordered probit model. The results suggest that fishing vessel accident severity is significantly affected by several types of accidents. Vessel damage severity is positively associated with loss of stability, sinking, daytime wind speed, vessel age, and distance to shore. Vessel damage severity is negatively associated with vessel size and daytime sea level pressure. Crew injury severity is also positively related to the loss of vessel stability and sinking. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. Cardiac Lymphatic Vessels, Transport, and Healing of the Infarcted Heart

    Directory of Open Access Journals (Sweden)

    Li-Hao Huang, PhD

    2017-08-01

    Full Text Available The lymphatic vasculature plays a key role in regulating tissue fluid homeostasis, lipid transport, and immune surveillance throughout the body. Although it has been appreciated that the heart relies on lymphatic vessels to maintain fluid balance and that such balance must be tightly maintained to allow for normal cardiac output, it has only recently come to light that the lymphatic vasculature may serve as a therapeutic target with which to promote optimal healing following myocardial ischemia and infarction. This article reviews the subject of cardiac lymphatic vessels and highlights studies that imply targeting of lymphatic vessel development or transport using vascular endothelial growth factor-C therapy may serve as a promising avenue for future clinical application in the context of ischemic injury.

  16. Reactor vessel lower head integrity

    Energy Technology Data Exchange (ETDEWEB)

    Rubin, A.M.

    1997-02-01

    On March 28, 1979, the Three Mile Island Unit 2 (TMI-2) nuclear power plant underwent a prolonged small break loss-of-coolant accident that resulted in severe damage to the reactor core. Post-accident examinations of the TMI-2 reactor core and lower plenum found that approximately 19,000 kg (19 metric tons) of molten material had relocated onto the lower head of the reactor vessel. Results of the OECD TMI-2 Vessel Investigation Project concluded that a localized hot spot of approximately 1 meter diameter had existed on the lower head. The maximum temperature on the inner surface of the reactor pressure vessel (RPV) in this region reached 1100{degrees}C and remained at that temperature for approximately 30 minutes before cooling occurred. Even under the combined loads of high temperature and high primary system pressure, the TMI-2 RPV did not fail. (i.e. The pressure varied from about 8.5 to 15 MPa during the four-hour period following the relocation of melt to the lower plenum.) Analyses of RPV failure under these conditions, using state-of-the-art computer codes, predicted that the RPV should have failed via local or global creep rupture. However, the vessel did not fail; and it has been hypothesized that rapid cooling of the debris and the vessel wall by water that was present in the lower plenum played an important role in maintaining RPV integrity during the accident. Although the exact mechanism(s) of how such cooling occurs is not known, it has been speculated that cooling in a small gap between the RPV wall and the crust, and/or in cracks within the debris itself, could result in sufficient cooling to maintain RPV integrity. Experimental data are needed to provide the basis to better understand these phenomena and improve models of RPV failure in severe accident codes.

  17. 46 CFR 42.05-63 - Ship(s) and vessel(s).

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Ship(s) and vessel(s). 42.05-63 Section 42.05-63... BY SEA Definition of Terms Used in This Subchapter § 42.05-63 Ship(s) and vessel(s). The terms ship(s) and vessel(s) are interchangeable or synonymous words, and include every description of watercraft...

  18. Vessel tree extraction using locally optimal paths

    DEFF Research Database (Denmark)

    Lo, Pechin Chien Pau; van Ginneken, Bram; de Bruijne, Marleen

    2010-01-01

    This paper proposes a method to extract vessel trees by continually extending detected branches with locally optimal paths. Our approach uses a cost function from a multi scale vessel enhancement filter. Optimal paths are selected based on rules that take into account the geometric characteristics...... of the vessel tree. Experiments were performed on 10 low dose chest CT scans for which the pulmonary vessel trees were extracted. The proposed method is shown to extract a better connected vessel tree and extract more of the small peripheral vessels in comparison to applying a threshold on the output...

  19. Electrically conductive containment vessel for molten aluminum

    Science.gov (United States)

    Holcombe, C.E.; Scott, D.G.

    1984-06-25

    The present invention is directed to a containment vessel which is particularly useful in melting aluminum. The vessel of the present invention is a multilayered vessel characterized by being electrically conductive, essentially nonwettable by and nonreactive with molten aluminum. The vessel is formed by coating a tantalum substrate of a suitable configuration with a mixture of yttria and particulate metal 10 borides. The yttria in the coating inhibits the wetting of the coating while the boride particulate material provides the electrical conductivity through the vessel. The vessel of the present invention is particularly suitable for use in melting aluminum by ion bombardment.

  20. Splenic vessel preservation versus splenic vessel resection in laparoscopic spleen-preserving distal pancreatectomy.

    Science.gov (United States)

    Hou, Baohua; Xiong, Dailan; Chen, Sheng; Ma, Tingting; Zhang, Chuanzhao; Zhou, Yu; Yin, Zi

    2017-11-09

    Laparoscopic spleen-preserving distal pancreatectomy for low-grade malignant pancreas tumours was recently demonstrated and can be performed with splenic vessel preservation (SVP) or splenic vessel resection (SVR). Whether one approach is superior to another is still a matter of debate. A systematic literature search (PubMed, Embase, Science Citation Index, Springer-Link and Cochrane Central Register of Controlled Trials) was performed. Pooled intra- and post-operative outcomes were evaluated. Stratified and sensitivity analyses were performed to explore heterogeneity between studies and to assess the effects of the study qualities. A total of six studies were included. There was no significant difference for SVR and SVP in terms of overall post-operative complications and the pooled odds ratio (OR) was 0.87 (95% confidence interval (CI) 0.55-1.38, I2  = 25%). Meta-analysis on the pooled outcome of intraoperative operative time and blood loss favoured SVR; the mean differences were 18.64 min (95% CI 6.91-30.37 min, I2  = 21%) and 65.67 mL (95% CI 18.88-112.45 mL, I2  = 48%), respectively. Subgroup analysis showed a decrease incidences in perigastric varices (OR = 0.07, 95% CI 0.03-0.18, I2  = 29%) and splenic infarction (OR = 0.16, 95% CI 0.08-0.32, I2  = 0%) in SVP. For selected patients who underwent laparoscopic spleen-preserving distal pancreatectomy, an increased preference for the SVP technique should be suggested considering its short-term benefits. However, in case of large tumours that distort and compress vessel course, SVR could be applied with acceptable splenic ischaemia and perigastric varices. © 2017 Royal Australasian College of Surgeons.

  1. Performance Evaluation Tests of Insulated Pressure Vessels for Vehicular Hydrogen Storage

    Energy Technology Data Exchange (ETDEWEB)

    Aceves, S M; Martinez-Frias, J; Espinoza-Loza, F

    2002-03-01

    Insulated pressure vessels are cryogenic-capable pressure vessels that can be fueled with liquid hydrogen or ambient-temperature compressed hydrogen. This flexibility results in multiple advantages with respect to compressed hydrogen tanks or low-pressure liquid hydrogen tanks. Our work is directed at verifying that commercially available aluminum-lined, fiber-wrapped pressure vessels can be safely used to store liquid hydrogen. A series of tests have been conducted, and the results indicate that no significant vessel damage has resulted from cryogenic operation. Future activities include a demonstration project in which the insulated pressure vessels will be installed and tested on two vehicles. A draft standard will also be generated for certification of insulated pressure vessels.

  2. Insulated Pressure Vessels for Vehicular Hydrogen Storage: Analysis and Performance Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Aceves, S M; Martinez-Frias, J; Garcia-Villazana, O; Espinosa-Loza, F

    2001-06-26

    Insulated pressure vessels are cryogenic-capable pressure vessels that can be fueled with liquid hydrogen (LH{sub 2}) or ambient-temperature compressed hydrogen (CH{sub 2}). Insulated pressure vessels offer the advantages of liquid hydrogen tanks (low weight and volume), with reduced disadvantages (fuel flexibility, lower energy requirement for hydrogen liquefaction and reduced evaporative losses). The work described here is directed at verifying that commercially available pressure vessels can be safely used to store liquid hydrogen. The use of commercially available pressure vessels significantly reduces the cost and complexity of the insulated pressure vessel development effort. This paper describes a series of tests that have been done with aluminum-lined, fiber-wrapped vessels to evaluate the damage caused by low temperature operation. All analysis and experiments to date indicate that no significant damage has resulted. Required future tests are described that will prove that no technical barriers exist to the safe use of aluminum-fiber vessels at cryogenic temperatures. Future activities also include a demonstration project in which the insulated pressure vessels will be installed and tested on two vehicles. A draft standard will also be generated for obtaining certification for insulated pressure vessels.

  3. Performance and Certification Testing of Insulated Pressure Vessels for Vehicular Hydrogen Storage

    Energy Technology Data Exchange (ETDEWEB)

    Aceves, S M; Martinez-Frias, J; Garcia-Villazana, O; Espinosa-Loza, F

    2001-06-03

    Insulated pressure vessels are cryogenic-capable pressure vessels that can be fueled with liquid hydrogen (LH2) or ambient-temperature compressed hydrogen (CH2). Insulated pressure vessels offer the advantages of liquid hydrogen tanks (low weight and volume), with reduced disadvantages (fuel flexibility, lower energy requirement for hydrogen liquefaction and reduced evaporative losses). The work described here is directed at verifying that commercially available pressure vessels can be safely used to store liquid hydrogen. The use of commercially available pressure vessels significantly reduces the cost and complexity of the insulated pressure vessel development effort. This paper describes a series of tests that have been done with aluminum-lined, fiber-wrapped vessels to evaluate the damage caused by low temperature operation. All analysis and experiments to date indicate that no significant damage has resulted. Required future tests are described that will prove that no technical barriers exist to the safe use of aluminum-fiber vessels at cryogenic temperatures. Future activities also include a demonstration project in which the insulated pressure vessels will be installed and tested on two vehicles. A draft standard will also be generated for obtaining certification for insulated pressure vessels.

  4. Gamma radiography of refractory-lined vessels and components

    Energy Technology Data Exchange (ETDEWEB)

    Lapinski, N. P.

    1978-08-01

    Materials used in coal-conversion systems are exposed to high pressure, high temperature, corrosive and erosive gases, and liquids containing particulate matter. These severe environments necessitate an assessment of the integrity of components to prevent premature failures. Gamma radiography was evaluated as a viable technique for testing such components in the laboratory or after operation in situ. Penetrameters (image-quality indicators) were developed for refractory-lined vessels and transfer lines, and exposure times for various combinations of refractory-steel thicknesses were determined. Radiography with /sup 60/Co was performed on gasifier vessels, combustor vessels, and critical transfer lines in existing pilot plants using the experience gained through laboratory experiments. The results show that gamma radiography is a practical and effective method to detect critical conditions in coal-conversion system components. 18 figures, 3 tables.

  5. Pkd1 regulates lymphatic vascular morphogenesis during development

    NARCIS (Netherlands)

    Coxam, Baptiste; Sabine, Amélie; Bower, Neil I; Smith, Kelly A; Pichol-Thievend, Cathy; Skoczylas, Renae; Astin, Jonathan W; Frampton, Emmanuelle; Jaquet, Muriel; Crosier, Philip S; Parton, Robert G; Harvey, Natasha L; Petrova, Tatiana V; Schulte-Merker, Stefan; Francois, Mathias; Hogan, Benjamin M

    2014-01-01

    Lymphatic vessels arise during development through sprouting of precursor cells from veins, which is regulated by known signaling and transcriptional mechanisms. The ongoing elaboration of vessels to form a network is less well understood. This involves cell polarization, coordinated migration,

  6. Maritime vessel obsolescence, life cycle cost and design service life

    Science.gov (United States)

    Dinu, O.; Ilie, A. M.

    2015-11-01

    Maritime vessels have long service life and great costs of building, manning, operating, maintaining and repairing throughout their life. Major actions are needed to repair, renovate, sometime built or even replace those scrapped when technology or demand changes determine obsolescence. It is regarded as a concern throughout vessel's entire life cycle and reflects changes in expectation regarding performances in functioning, safety and environmental effects. While service live may differ from physical lives, expectations about physical lives is the main factors that determines design service life. Performance and failure are illustrated conceptually and represented in a simplified form considering the evolution of vessels parameters during its service life. In the proposed methodology an accumulated vessel lifecycle cost is analyzed and obsolescence is characterized from ship's design, performances, maintenance and management parameters point of view. Romanian ports feeding Black Sea are investigated in order to provide comprehensive information on: number and types of vessels, transport capacity and life cycle length. Recommendations are to be made in order to insure a best practice in lifecycle management in order to reduce costs.

  7. Capacity problem in the power network. Transmission System Operator Tennet restricted by regulations; Capaciteitsprobleem op het net. Netbeheerder TenneT gevangen in regelgeving

    Energy Technology Data Exchange (ETDEWEB)

    Van Schoonhoven, M. [Norton Rose, Amsterdam (Netherlands)

    2007-09-15

    TenneT, the Dutch Transmission System Operator (TSO) has control of the national electricity transport grid. Beside the legal tasks, they also have the obligation of connecting parties to the transport grid and to transport electricity upon their request, all of which within the system of the Electricity Act. Due to the numerous construction plans for production capacity this is not an easy task, however. Question from the Dutch Lower House have even resulted in a study by the Dutch Office of Energy Regulation (DTe) on possibilities for improving current connection regulations. [mk]. [Dutch] TenneT heeft als de Nederlandse 'Transmission System Operator' (TSO) het beheer over het landelijk elektriciteitstransportnet. Dit omvat naast de bekende wettelijke taken ook de verplichting om binnen het systeem van de Elektriciteitswet partijen op het transportnet aan te sluiten en op hun verzoek elektriciteit te transporteren. Vanwege de talrijke bouwplannen voor productievermogen is dit echter niet eenvoudig. Vragen uit de Tweede Kamer hebben er zelfs toe geleid om de Dienst uitvoering en toezicht elektriciteitswet (DTe) een onderzoek te laten starten naar mogelijke verbetering van de huidige aansluitregels.

  8. AFSC/FMA/Vessel Assessment Logging

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Vessels fishing trawl gear, vessels fishing hook-and-line and pot gear that are also greater than 57.5 feet overall, and shoreside and floating processing facilities...

  9. Hawaii Abandoned Vessel Inventory, Hawaii Island

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Abandoned Vessel Project Data for Hawaii Island. Abandoned vessels pose a significant threat to the NOAA Trust resources through physical destruction of coral...

  10. US Virgin Islands Abandoned Vessel Inventory

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Abandoned Vessel Project Data for US Virgin Islands. Abandoned vessels pose a significant threat to the NOAA Trust resources through physical destruction of...

  11. Hawaii Abandoned Vessel Inventory, Midway Island, NWHI

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Abandoned Vessel Project Data for Midway Island, NWHI. Abandoned vessels pose a significant threat to the NOAA Trust resources through physical destruction of...

  12. Hawaii Abandoned Vessel Inventory, Kure, NWHI

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Abandoned Vessel Project Data for Kure, NWHI. Abandoned vessels pose a significant threat to the NOAA Trust resources through physical destruction of coral...

  13. Actemra Approved for Certain Blood Vessel Inflammation

    Science.gov (United States)

    ... 165836.html Actemra Approved for Certain Blood Vessel Inflammation Drug will treat adults with a condition called ... to treat adults with giant cell arteritis, an inflammation of the blood vessels (vasculitis). In a media ...

  14. Hawaii Abandoned Vessel Inventory, Maro Reef, NWHI

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Abandoned Vessel Project Data for Maro Reef, NWHI. Abandoned vessels pose a significant threat to the NOAA Trust resources through physical destruction of coral...

  15. PCs and networking for oceanographic research vessels

    Digital Repository Service at National Institute of Oceanography (India)

    Desai, R.G.P.; Desa, E.; Vithayathil, G.

    This paper, first describes briefly the evolution of data acquisition techniques and different system implementation, on board research vessels. A data acquisition system being developed for a coastal research vessel is then described which is based...

  16. Hawaii Abandoned Vessel Inventory, Lisianski Island, NWHI

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Abandoned Vessel Project Data for Lisianski Island, NWHI. Abandoned vessels pose a significant threat to the NOAA Trust resources through physical destruction...

  17. The ribB FMN riboswitch from Escherichia coli operates at the transcriptional and translational level and regulates riboflavin biosynthesis.

    Science.gov (United States)

    Pedrolli, Danielle; Langer, Simone; Hobl, Birgit; Schwarz, Julia; Hashimoto, Masayuki; Mack, Matthias

    2015-08-01

    FMN riboswitches are genetic elements that, in many bacteria, control genes responsible for biosynthesis and/or transport of riboflavin (vitamin B2 ). We report that the Escherichia coli ribB FMN riboswitch controls expression of the essential gene ribB coding for the riboflavin biosynthetic enzyme 3,4-dihydroxy-2-butanone-4-phosphate synthase (RibB; EC 4.1.99.12). Our data show that the E. coli ribB FMN riboswitch is unusual because it operates at the transcriptional and also at the translational level. Expression of ribB is negatively affected by FMN and by the FMN analog roseoflavin mononucleotide, which is synthesized enzymatically from roseoflavin and ATP. Consequently, in addition to flavoenzymes, the E. coli ribB FMN riboswitch constitutes a target for the antibiotic roseoflavin produced by Streptomyces davawensis. © 2015 FEBS.

  18. The Customs Regulation of Export-Import Operations in the Context of the Deep and Comprehensive Free Trade Area between Ukraine and the EU

    Directory of Open Access Journals (Sweden)

    Kuzmin Oleh Ye.

    2017-05-01

    Full Text Available The article is concerned with the problems of reforming the customs regulation of export-import operations in the context of the Deep and Comprehensive Free Trade Area between Ukraine and the EU. Both the goods and the territorial structures of Ukraine’s export-import activities with the EU Member States were analyzed. Trends in the cooperation of the foreign economic actors in the Lviv region with the EU counterparts were explored. The key activities carried out in Ukraine in the sphere of customs regulation in the context of implementation of the Deep and Comprehensive Free Trade Area between Ukraine and the EU have been outlined and characterized, in particular: administration of tariff quotas, issuance of certificates by the customs authorities for the transport of EUR 1 goods, granting of the status of authorized exporter to economic entities, launching of an automated system of customs services «One-stop window», transition to electronic declaration, etc. The results, problematic issues and benefits of implementing the above activities in the sphere of customs regulation of the export-import activities of enterprises have been characterized.

  19. dREAM co-operates with insulator-binding proteins and regulates expression at divergently paired genes

    Science.gov (United States)

    Korenjak, Michael; Kwon, Eunjeong; Morris, Robert T.; Anderssen, Endre; Amzallag, Arnaud; Ramaswamy, Sridhar; Dyson, Nicholas J.

    2014-01-01

    dREAM complexes represent the predominant form of E2F/RBF repressor complexes in Drosophila. dREAM associates with thousands of sites in the fly genome but its mechanism of action is unknown. To understand the genomic context in which dREAM acts we examined the distribution and localization of Drosophila E2F and dREAM proteins. Here we report a striking and unexpected overlap between dE2F2/dREAM sites and binding sites for the insulator-binding proteins CP190 and Beaf-32. Genetic assays show that these components functionally co-operate and chromatin immunoprecipitation experiments on mutant animals demonstrate that dE2F2 is important for association of CP190 with chromatin. dE2F2/dREAM binding sites are enriched at divergently transcribed genes, and the majority of genes upregulated by dE2F2 depletion represent the repressed half of a differentially expressed, divergently transcribed pair of genes. Analysis of mutant animals confirms that dREAM and CP190 are similarly required for transcriptional integrity at these gene pairs and suggest that dREAM functions in concert with CP190 to establish boundaries between repressed/activated genes. Consistent with the idea that dREAM co-operates with insulator-binding proteins, genomic regions bound by dREAM possess enhancer-blocking activity that depends on multiple dREAM components. These findings suggest that dREAM functions in the organization of transcriptional domains. PMID:25053843

  20. Serum- and Glucocorticoid-induced Protein Kinase 1 (SGK1) Is Regulated by Store-operated Ca2+ Entry and Mediates Cytoprotection against Necrotic Cell Death*

    Science.gov (United States)

    Brickley, Deanna R.; Agyeman, Abena S.; Kopp, Richard F.; Hall, Ben A.; Harbeck, Mark C.; Belova, Larissa; Volden, Paul A.; Wu, Wei; Roe, Michael W.; Conzen, Suzanne D.

    2013-01-01

    Serum and glucocorticoid-regulated kinase 1 (SGK1) encodes a phosphatidylinositol 3-kinase-dependent serine/threonine kinase that is rapidly induced in response to cellular stressors and is an important cell survival signal. Previous studies have suggested that an increase in cytoplasmic Ca2+ concentration ([Ca2+]c) is required for increased SGK1 expression, but the subcellular source of Ca2+ regulating SGK1 transcription remains uncertain. Activation of endoplasmic reticulum stress (ERS) with thapsigargin (TG) increased SGK1 mRNA and protein expression in MDA-MB-231 cells. Intracellular Ca2+ imaging revealed that store-operated Ca2+ entry played a prominent role in SGK1 induction by TG. Neither ERS nor release of Ca2+ from the ER was sufficient to activate SGK1. Prolonged elevation of intracellular Ca2+ levels, however, triggered cell death with a much greater proportion of the cells undergoing necrosis rather than apoptosis. A relative increase in the percentage of cells undergoing necrosis was observed in cells expressing a short hairpin RNA targeted to the SGK1 gene. Necrotic cell death evoked by cytoplasmic Ca2+ overloading was associated with persistent hyperpolarization of the inner mitochondrial membrane and a modest increase in calpain activation, but did not involve detectable caspase 3 or caspase 7 activation. The effects of cytoplasmic Ca2+ overloading on mitochondrial membrane potential were significantly reduced in cells expressing SGK1 compared with SGK1-depleted cells. Our findings indicate that store-operated Ca2+ entry regulates SGK1 expression in epithelial cells and suggest that SGK1-dependent cytoprotective signaling involves effects on maintaining mitochondrial function. PMID:24043625

  1. Serum- and glucocorticoid-induced protein kinase 1 (SGK1) is regulated by store-operated Ca2+ entry and mediates cytoprotection against necrotic cell death.

    Science.gov (United States)

    Brickley, Deanna R; Agyeman, Abena S; Kopp, Richard F; Hall, Ben A; Harbeck, Mark C; Belova, Larissa; Volden, Paul A; Wu, Wei; Roe, Michael W; Conzen, Suzanne D

    2013-11-08

    Serum and glucocorticoid-regulated kinase 1 (SGK1) encodes a phosphatidylinositol 3-kinase-dependent serine/threonine kinase that is rapidly induced in response to cellular stressors and is an important cell survival signal. Previous studies have suggested that an increase in cytoplasmic Ca(2+) concentration ([Ca(2+)]c) is required for increased SGK1 expression, but the subcellular source of Ca(2+) regulating SGK1 transcription remains uncertain. Activation of endoplasmic reticulum stress (ERS) with thapsigargin (TG) increased SGK1 mRNA and protein expression in MDA-MB-231 cells. Intracellular Ca(2+) imaging revealed that store-operated Ca(2+) entry played a prominent role in SGK1 induction by TG. Neither ERS nor release of Ca(2+) from the ER was sufficient to activate SGK1. Prolonged elevation of intracellular Ca(2+) levels, however, triggered cell death with a much greater proportion of the cells undergoing necrosis rather than apoptosis. A relative increase in the percentage of cells undergoing necrosis was observed in cells expressing a short hairpin RNA targeted to the SGK1 gene. Necrotic cell death evoked by cytoplasmic Ca(2+) overloading was associated with persistent hyperpolarization of the inner mitochondrial membrane and a modest increase in calpain activation, but did not involve detectable caspase 3 or caspase 7 activation. The effects of cytoplasmic Ca(2+) overloading on mitochondrial membrane potential were significantly reduced in cells expressing SGK1 compared with SGK1-depleted cells. Our findings indicate that store-operated Ca(2+) entry regulates SGK1 expression in epithelial cells and suggest that SGK1-dependent cytoprotective signaling involves effects on maintaining mitochondrial function.

  2. Collapsible Cryogenic Storage Vessel Project

    Science.gov (United States)

    Fleming, David C.

    2002-01-01

    Collapsible cryogenic storage vessels may be useful for future space exploration missions by providing long-term storage capability using a lightweight system that can be compactly packaged for launch. Previous development efforts have identified an 'inflatable' concept as most promising. In the inflatable tank concept, the cryogen is contained within a flexible pressure wall comprised of a flexible bladder to contain the cryogen and a fabric reinforcement layer for structural strength. A flexible, high-performance insulation jacket surrounds the vessel. The weight of the tank and the cryogen is supported by rigid support structures. This design concept is developed through physical testing of a scaled pressure wall, and through development of tests for a flexible Layered Composite Insulation (LCI) insulation jacket. A demonstration pressure wall is fabricated using Spectra fabric for reinforcement, and burst tested under noncryogenic conditions. An insulation test specimens is prepared to demonstrate the effectiveness of the insulation when subject to folding effects, and to examine the effect of compression of the insulation under compressive loading to simulate the pressure effect in a nonrigid insulation blanket under the action atmospheric pressure, such as would be seen in application on the surface of Mars. Although pressure testing did not meet the design goals, the concept shows promise for the design. The testing program provides direction for future development of the collapsible cryogenic vessel concept.

  3. Results of long-term field tests of protective earthing device for vessel electric systems

    Directory of Open Access Journals (Sweden)

    Blaginin V.A.

    2015-03-01

    Full Text Available The results of prolonged natural tests of protective neutral earthing device for controlling the fire and electrical safety of vessel electric systems have been shown. The use of such devices provides safe single-phase fault currents and reducing arc overvoltage during the long-term operation of a ship. The results of long-term monitoring of the device operation as part of the existing vessel electric power system have confirmed its effectiveness

  4. 50 CFR 660.704 - Vessel identification.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Vessel identification. 660.704 Section 660.704 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 660.704 Vessel identification. (a) General. This section only applies to commercial fishing vessels...

  5. 50 CFR 660.504 - Vessel identification.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Vessel identification. 660.504 Section 660.504 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... § 660.504 Vessel identification. (a) Official number. Each fishing vessel subject to this subpart must...

  6. 50 CFR 665.16 - Vessel identification.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Vessel identification. 665.16 Section 665... identification. (a) Applicability. Each fishing vessel subject to this part, except those identified in paragraph (e) of this section, must be marked for identification purposes, as follows: (1) A vessel that is...

  7. Global harmonization of safety regulations for the use of industrial robots-permission of collaborative operation and a related study by JNIOSH.

    Science.gov (United States)

    Saito, Tsuyoshi; Hoshi, Toshiro; Ikeda, Hiroyasu; Okabe, Kohei

    2015-01-01

    In December 2013, the Japanese Ministry of Health, Labour and Welfare (MHLW) partially amended the safety regulations for use of industrial robots so that "collaborative operation" could be performed at Japanese worksites as allowed in the ISO standard for industrial robots. In order to show global harmonization of Japanese legislation on machinery safety and problems with applying ISO safety standards to Japanese worksites, this paper reports the progress of a research study which have been conducted in National Institute of Occupational Safety and Health, Japan from 2011 to the present at the request of MHLW to examine the necessity and effect of the amendment. In the first phase of this study, a questionnaire survey was conducted among domestic robot manufacturers and users. The obtained results revealed their potential demand for the collaborative operation and problems concerning their risk assessment and rule-based risk reduction. To solve the problems, we propose a method based on an investigation result of the regulatory framework for safety of machinery in the European Union. Furthermore, a model of robot system capable of demonstrating the collaborative operation and risk reduction measures which is being developed to support appropriate implementation of the amendment is also described.

  8. Control Performance of General Electric Fuel and Torque Regulator Operating on T31-3 Turbine-Propeller Engine in Sea-Level Test Stand

    Science.gov (United States)

    Oppenheimer, Frank L.; Lazar, James

    1951-01-01

    A .General Electric fuel and torque regulator was tested in conjunction with a T31-3 turbine-propeller engine in the sea-level static test stand at the NACA Lewis laboratory. The engine and control were operated over the entire speed range: 11,000 rpm, nominal flight idle, to 13,000 rpm, full power. Steady-state and transient data were recorded and are presented with a description of the four control loops being used in the system. Results of this investigation indicated that single-lever control operation was satisfactory under conditions of test. Transient data presented showed that turbine-outlet temperature did overshoot maximum operating value on acceleration but that the time duration of overshoot did not exceed approximately 1 second. This temperature limiting resulted from a control on fuel flow as a function of engine speed. Speed and torque first reached their desired values 0.4 second from the time of change in power-setting lever position. Maximum speed overshoot was 3 percent.

  9. Blood vessel modeling for interactive simulation of interventional neuroradiology procedures.

    Science.gov (United States)

    Kerrien, E; Yureidini, A; Dequidt, J; Duriez, C; Anxionnat, R; Cotin, S

    2017-01-01

    Endovascular interventions can benefit from interactive simulation in their training phase but also during pre-operative and intra-operative phases if simulation scenarios are based on patient data. A key feature in this context is the ability to extract, from patient images, models of blood vessels that impede neither the realism nor the performance of simulation. This paper addresses both the segmentation and reconstruction of the vasculature from 3D Rotational Angiography data, and adapted to simulation: An original tracking algorithm is proposed to segment the vessel tree while filtering points extracted at the vessel surface in the vicinity of each point on the centerline; then an automatic procedure is described to reconstruct each local unstructured point set as a skeleton-based implicit surface (blobby model). The output of successively applying both algorithms is a new model of vasculature as a tree of local implicit models. The segmentation algorithm is compared with Multiple Hypothesis Testing (MHT) algorithm (Friman et al., 2010) on patient data, showing its greater ability to track blood vessels. The reconstruction algorithm is evaluated on both synthetic and patient data and demonstrate its ability to fit points with a subvoxel precision. Various tests are also reported where our model is used to simulate catheter navigation in interventional neuroradiology. An excellent realism, and much lower computational costs are reported when compared to triangular mesh surface models. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. ITER cryostat main chamber and vacuum vessel pressure suppression system design

    Energy Technology Data Exchange (ETDEWEB)

    Ito, Akira; Nakahira, Masataka; Takahashi, Hiroyuki; Tada, Eisuke [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Nakashima, Yoshitane; Ueno, Osamu

    1999-03-01

    Design of Cryostat Main Chamber and Vacuum Vessel Pressure Suppression System (VVPS) of International Thermonuclear Experimental Reactor (ITER) has been conducted. The cryostat is a cylindrical vessel that includes in-vessel component such as vacuum vessel, superconducting toroidal coils and poloidal coils. This cryostat provides the adiabatic vacuum about 10{sup -4} Pa for the superconducting coils operating at 4 K and forms the second confinement barrier to tritium. The adiabatic vacuum is to reduce thermal loads applied to the superconducting coils and their supports so as to keep their temperature 4 K. The VVPS consists of a suppression tank located under the lower bio-shield and 4 relief pipes to connect the vacuum vessel and the suppression tank. The VVPS is to keep the maximum pressure rise of the vacuum vessel below the design value of 0.5 MPa in case of the in-vessel LOCA (water spillage from in-vessel component). The spilled water and steam are lead to the suppression tank through the relief pipes when the internal pressure of vacuum vessel is over 0.2 MPa, and then the internal pressure is kept below 0.5 MPa. This report summarizes the structural design of the cryostat main chamber and pressure suppression system, together with their fabrication and installation. (author)

  11. Frequency primary regulation (FPR). Implications of the down stream flow variations. Operation methodology; Regulacion primaria de frecuencia (RPF). Implicancia por las variaciones del caudal aguas abajo. Metodologia de operacion

    Energy Technology Data Exchange (ETDEWEB)

    Morandi, Hector Enrique; Martelli, Jose Francisco [Ente Ejecutivo Presa Embalse Casa de Piedra, Buenos Aires (Argentina)]. E-mail: cdpba@impsat1.com.br

    1998-07-01

    This paper describes the Frequency Primary Regulation - FPR, determining that the operator running of a hydroelectric power plant must observe a set of norms, actions, etc, aiming to reduce as much as possible the environmental impact following the important modifications introduced. The regulation of the water flux downstream is one of the priority imposed to the project of a hydroelectric power plant. The regulation also allows other benefits as follows: the use of potentially or effectively flooded increasing the productive area; the efficient operation of water influx for various uses; the elimination of crop losses due to lack of irrigation water during certain seasons.

  12. Fishing effort control regulations influence on stability, safety and operability of small fishing vessels: study of a series of stability related accidents occurred in Spain between 2004 and 2007

    OpenAIRE

    Mata Álvarez-Santullano, Francisco

    2014-01-01

    Entre los años 2004 y 2007 se hundieron por problemas de estabilidad cinco pesqueros españoles de pequeña eslora, de características parecidas, de relativamente poca edad, que habían sido construidos en un intervalo de pocos años. La mayoría de los tripulantes de esos pesqueros fallecieron o desaparecieron en esos accidentes. Este conjunto de accidentes tuvo bastante repercusión social y mediática. Entre ingenieros navales y marinos del sector de la pesca se relacionó estos accidentes con lo...

  13. Recertification of the air and methane storage vessels at the Langley 8-foot high-temperature structures tunnel

    Science.gov (United States)

    Hudson, C. M.; Girouard, R. L.; Young, C. P., Jr.; Petley, D. H.; Hudson, J. L., Jr.; Hudgins, J. L.

    1977-01-01

    This center operates a number of sophisticated wind tunnels in order to fulfill the needs of its researchers. Compressed air, which is kept in steel storage vessels, is used to power many of these tunnels. Some of these vessels have been in use for many years, and Langley is currently recertifying these vessels to insure their continued structural integrity. One of the first facilities to be recertified under this program was the Langley 8-foot high-temperature structures tunnel. This recertification involved (1) modification, hydrotesting, and inspection of the vessels; (2) repair of all relevant defects; (3) comparison of the original design of the vessel with the current design criteria of Section 8, Division 2, of the 1974 ASME Boiler and Pressure Vessel Code; (4) fracture-mechanics, thermal, and wind-induced vibration analyses of the vessels; and (5) development of operating envelopes and a future inspection plan for the vessels. Following these modifications, analyses, and tests, the vessels were recertified for operation at full design pressure (41.4 MPa (6000 psi)) within the operating envelope developed.

  14. Influence of cerebral blood vessel movements on the position of perivascular synapses

    Science.gov (United States)

    DeFelipe, Javier

    2017-01-01

    Synaptic activity is regulated and limited by blood flow, which is controlled by blood vessel dilation and contraction. Traditionally, the study of neurovascular coupling has mainly focused on energy consumption and oxygen delivery. However, the mechanical changes that blood vessel movements induce in the surrounding tissue have not been considered. We have modeled the mechanical changes that movements of blood vessels cause in neighboring synapses. Our simulations indicate that synaptic densities increase or decrease during vascular dilation and contraction, respectively, near the blood vessel walls. This phenomenon may alter the concentration of neurotransmitters and vasoactive substances in the immediate vicinity of the vessel wall and thus may have an influence on local blood flow. PMID:28199396

  15. Assessment of whipping and springing on a large container vessel

    Directory of Open Access Journals (Sweden)

    Barhoumi Mondher

    2014-06-01

    Full Text Available Wave induced vibrations increase the fatigue and extreme loading, but this is normally neglected in design. The industry view on this is changing. Wave induced vibrations are often divided into springing and whipping, and their relative contribution to fatigue and extreme loading varies depending on ship design. When it comes to displacement vessels, the contribution from whipping on fatigue and extreme loading is particularly high for certain container vessels. A large modern design container vessel with high bow flare angle and high service speed has been considered. The container vessel was equipped with a hull monitoring system from a recognized supplier of HMON systems. The vessel has been operating between Asia and Europe for a few years and valuable data has been collected. Also model tests have been carried out of this vessel to investigate fatigue and extreme loading, but model tests are often limited to head seas. For the full scale measurements, the correlation between stress data and wind data has been investigated. The wave and vibration damage are shown versus heading and Beaufort strength to indicate general trends. The wind data has also been compared to North Atlantic design environment. Even though it has been shown that the encountered wind data has been much less severe than in North Atlantic, the extreme loading defined by IACS URS11 is significantly exceeded when whipping is included. If whipping may contribute to collapse, then proper seamanship may be useful in order to limit the extreme loading. The vibration damage is also observed to be high from head to beam seas, and even present in stern seas, but fatigue damage in general is low on this East Asia to Europe trade.

  16. Measurements of clothing insulation with a thermal manikin operating under the thermal comfort regulation mode: comparative analysis of the calculation methods.

    Science.gov (United States)

    Oliveira, A Virgílio M; Gaspar, Adélio R; Quintela, Divo A

    2008-11-01

    The present work is dedicated to a comparative analysis of calculation methods about clothing insulation with a thermal manikin operating under the thermal comfort regulation mode. The serial, global, and parallel calculation methods are considered and the thermal insulation results for garments (30) and ensembles (9) are discussed. The serial and parallel methods presents the higher and lower values, respectively, and the differences were sometimes significant. Considering the results for the effective thermal insulation, the mean values of the relative differences between the serial and global methods were 25.7% for the daily wear garments, 45.2% for the cold protective garments and 38.5% for the ensembles. The corresponding mean values for the global and parallel methods were 8.7, 15.8, and 10.5%, respectively. Since any uneven clothing insulation is to be expected as a source of error, particular care must be required when the calculation methods deal with cold protective clothing.

  17. Upstream open reading frames of the barley Mla13 powdery mildew resistance gene function co-operatively to down-regulate translation.

    Science.gov (United States)

    Halterman, Dennis A; Wise, Roger P

    2006-05-01

    SUMMARY To protect themselves against pathogen infection, plants have evolved multifarious defence mechanisms that include the production of antimicrobial compounds and hypersensitive cell death. This defence includes the regulation of expression of resistance proteins, which function to detect pathogen effectors and control the response. Barley Mla is one of several Ml genes that confer specific resistance to the powdery mildew fungus, Blumeria graminis f. sp. hordei. The Mla13 allele contains a long (523 nt) transcript leader region with three upstream open reading frames (uORFs) and two alternatively spliced introns. The lengths of the Mla13 uORFs, which encode up to 70 amino acid peptides, are directly influenced by the splicing of these introns. We have used in vivo and in vitro translation assays to show that Mla13 uORFs function co-operatively to down-regulate translation of the parent cistron up to 13-fold. However, resistance conferred by constitutively transcribed Mla appears to be unaffected by removal of these uORFs, signifying that a potential increase in MLA13 protein is innocuous to barley cells. In addition, cells that possess a predicted increase in MLA13 translation via over-expression and uORF mutation retain their requirement for RAR1, suggesting that this increase is not sufficient to overcome the concentration threshold required for activation of RAR1-independent resistance.

  18. Roles of store-operated Ca2+ channels in regulating cell cycling and migration of human cardiac c-kit+ progenitor cells.

    Science.gov (United States)

    Che, Hui; Li, Gang; Sun, Hai-Ying; Xiao, Guo-Sheng; Wang, Yan; Li, Gui-Rong

    2015-11-15

    Cardiac c-kit(+) progenitor cells are important for maintaining cardiac homeostasis and can potentially contribute to myocardial repair. However, cellular physiology of human cardiac c-kit(+) progenitor cells is not well understood. The present study investigates the functional store-operated Ca(2+) entry (SOCE) channels and the potential role in regulating cell cycling and migration using confocal microscopy, RT-PCR, Western blot, coimmunoprecipitation, cell proliferation, and migration assays. We found that SOCE channels mediated Ca(2+) influx, and TRPC1, STIM1, and Orai1 were involved in the formation of SOCE channels in human cardiac c-kit(+) progenitor cells. Silencing TRPC1, STIM1, or Orai1 with the corresponding siRNA significantly reduced the Ca(2+) signaling through SOCE channels, decreased cell proliferation and migration, and reduced expression of cyclin D1, cyclin E, and/or p-Akt. Our results demonstrate the novel information that Ca(2+) signaling through SOCE channels regulates cell cycling and migration via activating cyclin D1, cyclin E, and/or p-Akt in human cardiac c-kit(+) cells. Copyright © 2015 the American Physiological Society.

  19. 33 CFR 161.12 - Vessel operating requirements.

    Science.gov (United States)

    2010-07-01

    ... VTS. (b) If, in a specific circumstance, a VTS User is unable to safely comply with a measure or... respond promptly when hailed and communicate in the English language. Note to § 161.12(c): As stated in 47... Monitoring Areas Center MMSI 1 Call Sign Designated frequency (Channel designation)—purpose 2 Monitoring area...

  20. Vessel Traffic Service Watchstander Performance in Routine Operations

    Science.gov (United States)

    1979-10-01

    communicating, when the plot (as up to date, and when the traffic situation was well understood, there were periods of." free " time which watch- standers...Standurdizo Sol, for till wntch sections, with spech l emphasis on exceptions to basic traffic patterns. 5, IHxamine training procedures to ease